id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-277889-8u685f45	Costela-Ruiz, Víctor J.	SARS-CoV-2 infection: the role of cytokines in COVID-19 disease	2020-06-02		.txt	text/plain	9212	552	49	The majority of patients infected with COVID-19 have normal or reduced white cell counts and lymphocytopenia, and those with severe disease have shown significantly elevated levels of neutrophils, dimer-D, and urea in blood, with a continuing decrease in lymphocytes. detected elevated levels of the antagonistic receptor of IL-1 (IL-1Ra) in 14 severe cases of COVID-19, and this marker has been associated with increased viral load, loss of pulmonary function, lung damage, and mortality risk [55] . observed that its expression during infection with an influenza virus had negative effects on CD8 + memory T cells [71] .Various studies of COVID-19 patients have detected elevated IL-4 levels as part of the cytokine storm associated with severe respiratory symptoms [16, 17, 43, 72] . Elevated IL-17 levels have been reported in patients with SARS-CoV-2 as part of the cytokine storm [17] , and they have been associated with the viral load and disease severity [56] .	./cache/cord-277889-8u685f45.txt	./txt/cord-277889-8u685f45.txt