id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-252569-9rv1p3qh	Zanella, M.-C.	High-throughput sequencing for the aetiologic identification of viral encephalitis, meningoencephalitis, and meningitis. A narrative review and clinical appraisal	2019-01-11		.txt	text/plain	4175	204	34	Inclusion criteria were studies including patients with encephalitis, meningoencephalitis, or meningitis of unknown origin and reporting the use of HTS for the aetiologic identification of a viral origin in CNS samples. HTS was performed retrospectively in 18 studies and prospectively as part of the initial work-up in 11 case reports with an impact on the clinical management of three immunocompromised patients: a child with encephalitis associated with HAstV-VA1 [23] ; an adult with encephalitis associated with HAstV-VA1 [33] ; and an adult with chronic meningoencephalitis associated with Cache Valley virus [30] . In most studies, the approach to establish causality was not explicitly described, but was reported as the temporal association of clinical manifestations and the identification of viral sequences of a specific virus using HTS on CNS samples at the time of manifestations.	./cache/cord-252569-9rv1p3qh.txt	./txt/cord-252569-9rv1p3qh.txt