id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-017361-2lrmg6z0	Ballinger, Megan N.	Innate Immune Responses in Ventilator-Associated Pneumonia	2012-10-26		.txt	text/plain	10213	500	37	The compensatory release of anti-in fl ammatory molecules in sepsis is believed to mediate immunosuppression during the peri-septic or post-injury period, during which time immune cell function is substantially impaired (historically referred to as critical illness-induced leukocyte "deactivation" or "immunoparalysis"). Leukocyte reprogramming appears to be of considerable clinical signi fi cance, as higher rates of nosocomial infection and increased mortality are observed in postoperative, burn injury or septic patients who display evidence of monocyte deactivation, either in the form of decreased monocyte HLA-DR expression, ex vivo cytokine production or impaired delayed-type hypersensitivity responses (Appel et al. While these latter molecules could contribute to suppression of TLR-mediated responses during critical illness, there is no data to show enhanced expression and/or activity in blood monocytes or lung macrophages in patients at risk for the development of VAP.	./cache/cord-017361-2lrmg6z0.txt	./txt/cord-017361-2lrmg6z0.txt