id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-007593-45ynhqmf	Rauch, Helene C.	Chronic Theiler's virus infection in mice: appearance of myelin basic protein in the cerebrospinal fluid and serum antibody directed against MBP	2002-11-13		.txt	text/plain	4995	277	55	title: Chronic Theiler's virus infection in mice: appearance of myelin basic protein in the cerebrospinal fluid and serum antibody directed against MBP Myelin basic protein (MBP) appears frequently in the cerebrospinal fluid (CSF) of mice with chronic demyelination following intracerebral infection with Theiler's murine encephalomyelitis virus (TMEV); antibody to MBP can frequently be found in the sera. We have eliminated TMEV viral protein as a source of a common or cross-reacting epitope by both absorption and immunoblot analysis, but the mechanism of induction of Ab[MBP] and its role, if any, in the clinical and pathologic development of TMEV-associated demyelination remains to be determined. The incidence at 12 weeks coincides with the mean onset of clinical signs of TMEV-associated demyelination and the presence of MBP in the CSF of these animals.	./cache/cord-007593-45ynhqmf.txt	./txt/cord-007593-45ynhqmf.txt