id author title date pages extension mime words sentences flesch summary cache txt cord-005014-qp4rrwr4 Martin, R. Persistent intrathecal secretion of oligoclonal, Borrelia burgdorferi-specific IgG in chronic meningoradiculomyelitis 1988 .txt text/plain 2885 158 45 The diagnosis is confirmed by high titres of serum and CSF antibodies, specific for Borrelia burgdorferi, which has recently been identified as the aetiological agent of Lyme disease and Bannwarth's syndrome [2] . The purpose of our study was to answer the questions whether the CSF immunoglobulin G (IgG) in lymphomeningoradiculitis is locally produced, whether its antigen specificity can be determined, and whether the persistence of a specific distribution pattern can be recorded over the course of the disease. In the present study, we used a rapid and sensitive immunoblotting technique [6] to detect and characterize intrathecally produced IgG in five patients suffering from chronic meningoradiculitis (Bannwarth's syndrome) or radiculomyelitis. The presence of oligoclonal IgG bands in the CSF and not in the serum of patients suffering from meningoradiculitis or radiculomyelitis strongly favours the intrathecal production of these antibodies and was firstly demonstrated by Kriiger et al. ./cache/cord-005014-qp4rrwr4.txt ./txt/cord-005014-qp4rrwr4.txt