id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-330411-hg1cxcs7	Keddie, S.	Laboratory biomarkers associated with COVID-19 severity and management	2020-10-22		.txt	text/plain	2407	138	46	This study investigates the routine laboratory tests and cytokines implicated in COVID-19 for their potential application as biomarkers of disease severity, respiratory failure and need of higher-level care. From analysis of 203 samples, CRP, IL-6, IL-10 and LDH were most strongly correlated with the WHO ordinal scale of illness severity, the fraction of inspired oxygen delivery, radiological evidence of ARDS and level of respiratory support (p ≤ 0.001). This study comprehensively explored clinical disease features and routine laboratory tests against specialist cytokine biomarkers associated with COVID-19 disease and its complications, to address their association with disease severity, respiratory intervention and outcome. Biomarker analysis of CRP, LDH and the cytokines IL-6, IL-10 and TNFα, alongside thorough clinical assessment of COVID-19 patients, enables more accurate stratification of high from low risk cases and the need for intensive care support.	./cache/cord-330411-hg1cxcs7.txt	./txt/cord-330411-hg1cxcs7.txt