id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-103653-hgnz0fkv	Wyse, C.	Seasonal and Daytime Variation in Multiple Immune Parameters in Humans: Evidence from 329,261 Participants of the UK Biobank Cohort	2020-10-27		.txt	text/plain	6240	311	40	Making use of extensive data from the UK Biobank cohort, we investigate seasonal and daytime variability in multiple immune parameters (inflammatory markers, white blood cell counts and antibody titres), and test for associations with a wide range of environmental and lifestyle factors. Individual-level data were linked to other factors that vary over seasonal and daily cycles, including changes in day length, outdoor temperature and vitamin D at the time the blood sample was collected. 45 The acute phase protein, CRP showed a weak daily pattern in this study, with levels higher in daytime, again corroborating previous reports of diurnal patterns of CRP humans 73, 52, 74, 75 Circadian rhythms in circulation and tissue migration of monocytes in mice are regulated through an innate cell-intrinsic clock mechanism and their oscillation coincides with an enhanced inflammatory response when monocytes are decreasing at the beginning of the rest phase 72 and increased lethality of endotoxic challenge at this time.	./cache/cord-103653-hgnz0fkv.txt	./txt/cord-103653-hgnz0fkv.txt