key: cord-346461-eqyte6ko authors: Scialpi, Michele title: Pneumonia misinterpretation in COVID-19: revisitation and update date: 2020-08-28 journal: Int J Infect Dis DOI: 10.1016/j.ijid.2020.08.067 sha: doc_id: 346461 cord_uid: eqyte6ko nan and the signs of DAD and no signs of suppurative bronchopneumonia are reported histologically. In patients who died from COVID-19, autopsy studies revealed pneumonia from 0 to 48% of cases (17) (18) (19) . Finally, the histopathological findings in the lung of patients who died of COVID-19 are similar to those described in Middle East respiratory syndrome coronavirus (MERS-CoV) (22,23), suggesting similarities in the pathogenesis and the mechanisms of lung tissue damage. In conclusion, the rivisitation of the pneumonia in patients who died of COVID-19, revealed a discrepancy between the CT signs identified as "pneumonia, COVID-related" and histology. Lung histopatologic fetures are mainly related to ADA and/or associated with PE and a conseguent respiratory failure causing death in COVID-19 patients. These knowledge are essential to improve the clinical approach and to reduce mortality in COVID-19 patients. Author contributions: study design: MS; writing manuscript: MS; editing manuscript:MS; literature research:MS. The author declares that there are no sponsors for this study. Ethical Approval not required. The Author does not declare any conflict of interest associated for the manuscript entiltled "Pneumonia misinterpretation in COVID-19: revisitation and update". Chest CT for typical 2019-nCoV pneumonia: relationship to negative RT-PCR testing Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan CT imaging features of 2019 novel coronavirus (2019-nCoV). Radiology. 2020 Performance of radiologists in differentiating COVID-19 from viral pneumonia on chest CT Early clinical and CT manifestations of coronavirus disease 2019 (COVID-19) pneumonia CT manifestations of two cases of 2019 novel coronavirus (2019-nCoV) pneumonia The clinical and chest CT features associated with severe and critical COVID-19 pneumonia Emerging 2019 novel coronavirus (2019-nCoV) pneumonia Chest CT features of COVID-19 in Rome Temporal changes of CT findings in 90 patients with COVID-19 pneumonia: a longitudinal study Time course of lung changes on chest CT during recovery from The progression of computed tomographic (CT) images in patients with coronavirus disease (COVID-19) pneumonia: the CT progression of COVID-19 pneumonia Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The experience of clinical immunologists from China Comorbidities and multi-organ injuries in the treatment of COVID Post-mortem examination of COVID19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings of lungs and other organs suggesting vascular dysfunction Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19 Autopsy findings and venous thromboembolism in patients with COVID-19: a prospective cohort study Acute pulmonary embolism: relationships between ground-glass opacification at thin-section CT and hemodynamics in pigs Pulmonary embolism in patients with COVID-19: Time to change the paradigm of computed tomography associated with acute respiratory distress syndrome Histopathology of Middle East respiratory syndrome coronovirus (MERS-CoV) infection-clinicopathological and ultrastructural study