key: cord-318312-v1c3qm7h authors: Fischer, Quentin; Darmon, Arthur; Ducrocq, Grégory; Feldman, Laurent title: Case report of anterior ST-elevation myocardial infarction in a patient with coronavirus disease-2019 date: 2020-05-19 journal: Eur Heart J Case Rep DOI: 10.1093/ehjcr/ytaa131 sha: doc_id: 318312 cord_uid: v1c3qm7h BACKGROUND: Coronavirus disease-2019 (COVID-19) is an infectious disease appeared in China in December 2019 and, since then, has spread worldwide at a rapid pace. CASE SUMMARY: A patient with COVID-19 was hospitalized in our institution for a diabetic foot ulcer and presented afterwards a pulmonary oedema and concomitant anterior ST-segment elevation myocardial infarction. We report here on the initial presentation, coronary care and intervention, and clinical course of this patient. DISCUSSION: Emergent percutaneous coronary intervention is feasible and safe in COVID-19 patients but requires a multidisciplinary effort involving caregivers from infectious disease, intensive care, and cardiology teams. Coronavirus disease-2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The outbreak of COVID-19 appeared in China in December 2019 and, since then, has spread worldwide at a rapid pace and has been declared a global pandemic by the World Health Organization as of 11 March 2020. 1 Patients with hypertension, diabetes, or cardiovascular disease are at high risk of being affected by COVID-19 2 and have more severe outcomes. 3 Cardiovascular complications of COVID-19 include myocardial injury, myocarditis, type 1 or type 2 myocardial infarction, heart failure, cardiogenic shock, severe arrhythmias, and venous thrombo-embolic disease. 4 Specifically, the occurrence of acute coronary syndromes (ACS) in Learning points • Coronavirus disease-2019 (COVID-19) screening by naso-pharyngeal swab was not systematically performed at admission and should not delay emergent cardiological care in ST-elevation myocardial infarction or high-risk non-ST-elevation myocardial infarction. • The occurrence of acute coronary syndrome will increase in COVID-19 pandemic, due to several parameters such as the profound inflammatory response and cytokine storm syndrome associated with severe acute respiratory syndrome coronavirus 2 infection. 5 While the general management of ACS has been well-defined in international guidelines, reports of ACS in COVID-19 patients are scarce, and there is no clear recommendation as regard to optimal treatment in such patients. 4 A 63-year-old male patient was hospitalized for a neuro-ischaemic diabetic foot ulcer in the diabetology department of our institution on 18 March 2020. He had several cardiovascular risk factors, including type-2 diabetes mellitus, hypertension, dyslipidaemia, and was an active smoker. He had no history of heart disease, but had undergone percutaneous transluminal angioplasty of the right femoral artery 5 years earlier. The patient reported no respiratory symptoms upon admission, but had complained of mild fever (38.5 C) for the last 5 days. Three days before hospitalization, he was prescribed a combination of amoxicillin 1000 mg and clavulanic acid 125 mg t.i.d. with no effect on fever. Shortly after admission, the patient became severely breathless and hypoxic (Sp0 2 85%) with a severe increase in blood pressure (226/118 mmHg). Physical examination showed normal cardiac murmurs, tachypnoea, and crackles in both lung fields without any other signs of congestion. No significant repolarization abnormality was observed on electrocardiogram (ECG). An echocardiography showed normal left ventricular ejection fraction (LVEF), high left ventricular filling pressure (E/E 0 ratio at 23), and systolic pulmonary artery pressure (45 mmHg). The chest X-ray showed bilateral perihilar airspace opacity with dilatation of the main pulmonary artery ( Figure 1 ). Based on the clinical presentation, a diagnosis of acute pulmonary oedema was made and the patient was transferred to the intensive care unit (ICU) with strict respiratory isolation. The patient recovered within an hour on continuous positive airway pressure non-invasive ventilation, nitrates, and diuretics, allowing for complete oxygen weaning. Because of systematic suspicion of COVID-19 in patients with respiratory failure and fever, polymerase chain reaction was performed on a naso-pharyngeal swab and returned positive for -CoV-2. In addition, blood tests showed a biological Twelve hours later, the respiratory state of the patient deteriorated with persistent hypoxaemia (PaO 2 57 mmHg) despite ventilation with a high oxygen concentration mask (6 L/min). Although the patient had no chest pain, an ECG showed anterior ST-segment elevation. The patient received 4000 IU of intravenous unfractionated heparin, 250 mg of intravenous aspirin, and 180 mg of oral ticagrelor, and the patient was taken to the cathlab 150 min after the first abnormal ECG for emergent coronary angiography. The ECG recorded upon arrival in the cathlab showed persistent ST-segment elevation in the anterior leads with reciprocal changes in the inferior and lateral leads ( Figure 2) . The patient wore a surgical mask during the coronary angiography, while the interventional cardiologist and cathlab nurses wore protective equipments-including N95 mask, mobcap, gloves, plastic glasses, overshoes, and sterile gowns above the lead aprons-as advised by the local infection control unit, which was present during the procedure. In this case report, the occurrence of an acute respiratory distress in a patient with infected diabetic foot ulcer, led to the simultaneous diagnosis of COVID-19 and high-risk ACS. The medical teams involved with the care of the patient had to deal with several challenges. First, establish a formal diagnosis of COVID-19 and prevent COVID-19 transmission to the caregivers. Of note, COVID-19 screening was not performed upon initial admission since the patient's fever was attributed to his foot infection and he had no respiratory symptoms. However, it was systematically performed when his respiratory condition deteriorated, leading to implement the protective measures, pending the results of the naso-pharyngeal swab. Second, understand the aetiology of the two episodes of respiratory failure, which were not related to COVID-19, as suggested by the favourable clinical course on diuretics and oxygenation after the first episode, and the efficacy of PCI on symptoms after the second. Third, to perform emergent PCI in a safe environment in a patient with COVID-19, which has been recognized as a medical challenge recently. 6 In the present case, the transfer of the patient from the ICU to the cathlab took 150 min, an unusually long time for an inpatient presenting with ST-elevation ACS in a tertiary hospital with roundthe-clock cathlab availability. This long delay was attributed to the extremely tensed medical activity at the start of COVID-19 epidemics, especially in the ICU. However, the cathlab team took advantage of this long transfer to receive proper training by the infection control unit, such that appropriate protective measures had been implemented and PCI could be rapidly performed. In order to prevent time delay for emergent PCI, our current policy is to refer all patients with very-high risk ACS and suspected COVID-19 directly to the cathlab and to transfer them immediately afterward to the ICU. Fourth, even though it is unclear whether the ACS could be classified as a type 1 or type 2 myocardial infarction, the persistence of STsegment elevation before PCI despite a patent LAD suggests that a profound imbalance between oxygen supply and demand was the key determinant of this ACS. Alternatively, a vasospasm cannot be ruled out. Fifth, due to potential infectious hazards related to the close exposure to the COVID-19 patient, it was decided not to perform further imaging of the culprit atherosclerotic plaque with intravascular ultrasound or optical coherence tomography. Hence, it was impossible to assess whether atherosclerotic plaque rupture or erosion was present at the culprit site. The profound inflammatory response and cytokine storm syndrome associated with SARS-CoV-2 infection may confer a greater risk for atherosclerotic plaque rupture in susceptible patients, 7 and high prothrombotic state leading to transient occlusive arterial thrombosis. 8 Finally, there are reports of individual centres developing alternate strategies in the setting of the COVID-19 crisis, such as preferential use of fibrinolytic therapy in patients with ST-elevation myocardial infarction. 9 However, interventional approaches are more likely to improve the patient outcomes and should be preferred, provided they can be applied timely and without putting the caregivers at excessive risk of contamination. Emergent PCI for ACS is feasible and safe in COVID-19 patients but requires a multidisciplinary effort involving caregivers from infectious disease, intensive care, and cardiology teams. Quentin Fischer is a 31-year-old interventional cardiologist working in Bichat Hospital, Paris, France. He performed a fellowship in the Quebec Heart & Lung Institute, Quebec city, Canada. His research interests include optimizing myocardial revascularization in ST-segment elevation myocardial infarction and transcatheter valve technologies. Member of the Young Community of the European Society of Cardiology, he is also very involved in teaching students at the Medicine University. Supplementary material is available at European Heart Journal -Case Reports online. Slide sets: A fully edited slide set detailing this case and suitable for local presentation is available online as Supplementary data. The authors confirm that written consent for submission and publication of this case report including images and associated text has been obtained from the patient in line with COPE guidance. Conflict of interest: none declared. World Health Organization. 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