key: cord-316501-fl2wvhia
authors: Noh, Ji Yun; Yoon, Jin Gu; Seong, Hye; Choi, Won Suk; Sohn, Jang Wook; Cheong, Hee Jin; Kim, Woo Joo; Song, Joon Young
title: Asymptomatic infection and atypical manifestations of COVID-19: comparison of viral shedding duration
date: 2020-05-21
journal: J Infect
DOI: 10.1016/j.jinf.2020.05.035
sha: 
doc_id: 316501
cord_uid: fl2wvhia

• More than 25% of patients with COVID-19 were asymptomatic. • Among patients with COVID-19, 26.1% presented anosmia, and 22.6% complained of ageusia with median duration of 7 days. • Mean duration of SARS-CoV-2 viral shedding was 24.5 days. • Irrespective of clinical manifestations, all patients with COVID-19 showed prolonged viral shedding.

to evaluate the prevalence of asymptomatic infection, anosmia (smell loss) and ageusia (taste 8 loss) among patients with mild COVID-19 in a residential treatment center (RTC). We also 9 compared the duration of SARS-CoV-2 viral shedding between groups with different clinical 10 manifestations.

An observational cohort study was conducted for 199 patients with COVID-19 in a RTC at 

Among 199 patients with COVID-19, male was 34.7% and mean age of the patients was 26 38.0 years (Table 1) . Most patients (187, 94.0%) were healthy without chronic medical 27 conditions. Among 199 patients, 26.6% were asymptomatic. In the early study, asymptomatic 

This study has some limitations. Anosmia and ageusia were subjective symptoms.

Olfactory test was not performed, and quantitative scale of olfactory dysfunction was not 58 measured. In addition, viability of SARS-CoV-2 detected by PCR was not proven using viral 

Covid-19 in South Korea -Challenges of 80

Subclinical Manifestations

Rapid asymptomatic transmission of COVID-19 during 82 the incubation period demonstrating strong infectivity in a cluster of youngsters aged 16-83 23 years outside Wuhan and characteristics of young patients with COVID-19: A 84 prospective contact-tracing study

Self-reported olfactory and taste disorders in SARS-86

Clinical infectious diseases : an official publication 87 of the Infectious Diseases Society of America

Estimating the asymptomatic proportion of 89 coronavirus disease 2019 (COVID-19) cases on board the Diamond Princess cruise ship

The Covid-19 pandemic and otolaryngology: 93 What it comes down to?

Smell and taste disorders, a study of 750 patients 96 from the University of Pennsylvania Smell and Taste Center

Identification of viruses in patients with postviral 100 olfactory dysfunction

Severe acute respiratory 103 syndrome coronavirus infection causes neuronal death in the absence of encephalitis in 104 mice transgenic for human ACE2

High expression of ACE2 receptor of 2019-nCoV on the 107 epithelial cells of oral mucosa

Epithelial cells lining salivary gland ducts are early target 110 cells of severe acute respiratory syndrome coronavirus infection in the upper respiratory 111 tracts of rhesus macaques

Duration, mean ± SD 7.5 ± 5.6Anorexia 1 (0.5)