key: cord-312356-95yyi0jb authors: Hernández-Huerta, Daniel; Alonso-Sánchez, Elena Begoña; Carrajo-Garcia, Carmen Aldara; Montes-Rodríguez, José Manuel title: The impact of COVID-19 on Acute Psychiatric Inpatient Unit date: 2020-05-19 journal: Psychiatry Res DOI: 10.1016/j.psychres.2020.113107 sha: doc_id: 312356 cord_uid: 95yyi0jb nan make the virus difficult to contain: they lack respiratory isolation rooms, doors are firmly closed, wards are poorly ventilated and some patients have shared rooms, among others. Moreover, mental health staff often has inadequate training on the management of respiratory infectious diseases, which adds to some features of patients with pre-existing mental health conditions, such as inadequate insight or psychomotor excitement, being unable to practice infection control measures, as well as limited awareness regarding the risk of infection, that may contribute to the transmission of COVID-19. In fact, it has been evidenced that psychiatric patients are more susceptible to respiratory infections than general population (Xiang et al., 2020) . We are also facing new diagnostic challenges, as many patients admitted to the psychiatric ward are simultaneously been treated for COVID-19. Some drugs used to treat the SARS-CoV-2 pneumonia are associated with neuropsychiatric adverse events, which must be taken into consideration in the differential diagnosis. They can also have life-threatening interactions with psychotropic drugs, leading to increased toxicity and undesirable side-effects, such as QT interval prolongation (Uvais, 2020) . Hidroxicloroquine, lopinavir/ritonavir and corticosteroids can cause from mild complications, such as mood lability, depression or nervousness, to severe manifestations including psychosis, excitement and delirium (Abers et al., 2014; Oray et al., 2016; Uvais, 2020) . Additionally, we ought to be aware of other atypical neurological symptoms caused by SARS-CoV-2 neurotropism, as a recent case of encephalitis has already been reported (Moriguchi et al., 2020) . Furthermore, complementary treatments such as psychological and occupational therapy, family accompaniment or coordination with the outpatient clinics have been reduced or abolished. Similar difficulties have been described in delivering electroconvulsive therapy because of the shortage of personal protective equipments for healthcare staff who cannot perform such essential therapy in safe conditions (Tor et al., 2020) . Regrettably, because of the shortage of isolation rooms for SARS-CoV-2 positive cases who suffer from mental illness decompensation comorbidities, physical restraint practices could increase in order to guarantee confinement and infection control measures. All of these aspects above sadly seem to contribute to hinder inpatients' recovery process. The COVID-19 pandemic will probably lead to unprecedented changes in our National Health Care System, as well as in the Mental Health System. We call for the creation of state policies that mitigate the health impact of such catastrophe, with urgency in relation to patients at Acute Psychiatric Inpatient Units. These policies should include contingency plans alongside the redesign of healthcare settings to ensure that they will be suitable for new future outbreaks. Despite the ongoing health crisis, certain changes must be undertaken if we want to continue bringing acceptable healthcare for individuals with mental disorders. Neurological and Psychiatric Adverse Effects of Antiretroviral Drugs Lessons learned from the coronavirus health crisis in Madrid, Spain: How COVID-19 has changed our lives in the last two weeks A first Case of Meningitis/Encephalitis associated with SARS-Coronavirus-2 Long-term side effects of glucocorticoids ECT in a time of COVID-19 The Risks of Prescribing Hyodroxychloroquine in COVID-19-Infected Patients With Schizophrenia The COVID-19 outbreak and psychiatric hospitals in China: managing challenges through mental health service reform