key: cord-304636-houm2zcu authors: Guillan, Marta; Villacieros-Alvarez, Javier; Bellido, Sara; Peremarch, Concepcion Perez-Jorge; Suarez-Vega, Victor M.; Aragones-Garcia, Maria; Cabrera-Rojo, Celina; Fernandez-Ferro, Jose title: Unusual simultaneous cerebral infarcts in multiple arterial territories in a COVID-19 patient date: 2020-06-09 journal: Thromb Res DOI: 10.1016/j.thromres.2020.06.015 sha: doc_id: 304636 cord_uid: houm2zcu • In the occurrence of new-onset neurological symptoms in COVID-19 patients, we should suspect an acute ischemic stroke and not assume that it is secondary to the respiratory syndrome (hypoxia). Acute ischaemic stroke continues to be a treatable medical emergency also during the SARS-CoV-2 pandemic. • Arterial thrombotic events may not only occur as a complication in severe cases of COVID-19; but can also appear in mild-moderate cases due to other mechanisms. • Several pathogeneses may be behind ischemic strokes in COVID-19, in addition to the more evident coagulopathy associated with the severe infection. J o u r n a l P r e -p r o o f syndrome, neurological manifestations have been described in more than a third of patients, both in mild-moderate cases of the infection, as associated or as a complication in severe and critical cases. Anosmia, ageusia, myalgias and headache have been widely described in patients with mild symptoms; while acute cerebrovascular disease, seizures, polyneuritis and encephalopathies have been observed in the most severe cases [1, 2] . In this report, we present a patient who was admitted with a diagnosis of SARS-CoV-2 multilobar pneumonia who developed a complex cortical visual deficit consistent with a partial Anton's syndrome plus simultagnosia. A 67-year-old man with a history of hypertension, heavy smoking, and harmful alcohol consumption was brought to the emergency department after being found dazed and confused by his neighbours. He lived alone. His medications included enalapril and acetylsalicylic acid. Upon arrival at the emergency department, he reported a dry cough in the last five days without fever or chills as long as he could recall. On examination, hypoventilation was auscultated in both lungs, basal oxygen saturation was always higher than 93%, and he was afebrile and normotensive. A chest radiograph showed multilobar pneumonia and a nasopharyngeal swab reverse transcription-polymerase chain reaction (PCR) resulted positive for SARS-CoV-2. Consequently, he was admitted to the internal medicine department and treated with a combination of hydroxychloroquine, ceftriaxone and azithromycin. Prophylactic anticoagulation with LMWH and conventional low-flow nasal cannula oxygen therapy was also prescribed. The patient responded positively, without pulmonary complications and with a resolution of the respiratory syndrome both clinically and radiologically. A daily analysis showed peak levels of white cell count in 13.10 x 10³μl (lymphocytes 1.9 x 10³μl), fibrinogen 543 mg/dl, D-dimer 1777 μg/L, lactate dehydrogenase 341 IU/L, highsensitivity C reactive protein 3.86 mg/dl, serum ferritin 1107 μg/L; all other parameters were found within normal ranges. After fifteen days, the neurology service was consulted because the patient remains confused and a significant gait ataxia of undetermined time was detected. Neurological examination showed temporo-spatial disorientation, dysarthria, partial cortical blindness and anosognosia with visual confabulation, optic ataxia, difficulty in visual scanning, simultagnosia, and mild left hemihypoesthesia. An unenhanced brain CT We, therefore, present an unusual case of simultaneous multivessel cerebral infarctions, without known extracerebral thrombotic events, in a patient with a moderate COVID-19 who did not develop acute respiratory distress syndrome or disseminated intravascular coagulation. The temporal association with the infectious disease COVID-19, and the lack of other common causes of stroke, lead us to consider that they are associated. So far, the majority of published cases linking ischaemic stroke to COVID-19 were severe or critical COVID-19 cases with significant hemodynamic and analytical disturbances, especially with D-dimer rates above 5000 ng/mL [5, 6] . Moreover, the CSF-analysis, in this case, presented hyperproteinorraquia and lymphocytic pleocytosis greater than expected for an ischaemic stroke. Previous studies carried out in stroke patients showed a variable range of reactive pleocytosis up to 64 Mpt/L cell and nonspecific proteins up to 1507 mg/L in CSF [7] . In cases describing higher concentrations of cells and proteins, such as our case, pathogens J o u r n a l P r e -p r o o f causing vascular damage were found. The OCB mirror pattern in CSF (in which identical clones of IgG proteins are present in CSF and serum), suggests that the IgG has entered the central nervous system (CNS) from the systemic circulation, this passive filtration is facilitated by blood-brain barrier damage. This pattern only indicates systemic immune activation but it has been previously observed in cases of systemic viral infections with neurological involvement as cerebral vasculitis (the diagnosis of CNS vasculitis is difficult, in many cases cerebral biopsy is required and it is not always possible to confirm the presence of multiple cerebral artery stenosis in the imaging exam) [8] . It seems clear that patients with severe COVID-19 may suffer an ischaemic stroke or cerebral venous thrombosis because of the hypercoagulability that coincides with the critical illness [9] . But it seems reasonable too to consider that in milder COVID-19 syndromes, other pathophysiological mechanisms may well explain the occurrence of cerebral infarctions. Thereby in other viral infections that have been associated with a higher stroke risk, the vasculitis caused by a direct infection of the cerebral arteries; as well as sustained inflammation triggering instability of atherosclerotic plaque, and a transient thrombophilia have been proposed as the potential mechanisms lead to the cerebral ischaemia [10] . Further studies are needed to clarify the different pathogenic pathways by which COVID-19 may cause strokes and to identify the factors that put COVID patients at higher risk of suffering a stroke. The authors declare that there are no competing interests associated with the manuscript. The bottom row images depict axial T2 gradient echo sequences with blooming Neurological manifestations of hospitalized patients with COVID-19 in Wuhan, China: a retrospective case series study COVID-19-associated Acute Hemorrhagic Necrotizing Encephalopathy: CT and MRI Features Characteristics of ischaemic stroke associated with COVID-19 Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Low Diagnostic Yield of Routine Cerebrospinal Fluid Analysis in Juvenile Stroke Central nervous system vasculitis associated with hepatitis C virus infection: a brain MRI-supported diagnosis Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: An updated analysis Infections causing stroke or strokelike syndromes All patients in the stroke unit have signed an informed consent to collect and use their anonymised data for research purposes.