key: cord-303395-r0nj16l9 authors: Basirjafari, Sedighe; Rafiee, Masoumeh; Shahhosseini, Babak; Mohammadi, Mehdi; Neshin, Saeideh Aghayari Sheikh; Zarei, Mohammad title: Association of Pediatric COVID‐19 and Subarachnoid Hemorrhage date: 2020-08-14 journal: J Med Virol DOI: 10.1002/jmv.26434 sha: doc_id: 303395 cord_uid: r0nj16l9 We read with great interest an article from Li colleagues describing ¨The Neuroinvasive Potential of SARS‐CoV2 May Play a Role in the Respiratory Failure of COVID‐19 Patients¨. Here we describe subarachnoid hemorrhage (SAH) as a severe neurological manifestation associated with pediatric COVID‐19. This article is protected by copyright. All rights reserved. The other authors have indicated they have no potential conflicts of interest to disclose. Dear Editor: We read with great interest an article from Li and colleagues 1 This article is protected by copyright. All rights reserved. Moreover, ABO blood type might have a prognostic role in the severity of COVID-19. There is a positive association between ACE activity and the GATC haplotype of the ABO gene which is prevalent in non-O blood group. Thus, patients with blood type O might have protection against severe COVID-19 12 . However, patients with blood group type A, as the patient described in this report, might be more predisposed to severe infection. The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients Infection as a Stroke Trigger: Associations Between Different Organ System Infection Admissions and Stroke Subtypes A Case Series of children with 2019 novel coronavirus infection: clinical and epidemiological features Characteristics and Outcomes of Children With Coronavirus Disease 2019 (COVID-19) Infection Admitted to US and Canadian Pediatric Intensive Care Units Cerebrovascular Disease in Patients with COVID-19: A Review of the Literature and Case Series Evidence of the COVID-19 virus targeting the CNS: tissue distribution, host-virus interaction, and proposed neurotropic mechanisms COVID-19: Expression of ACE2-Receptors in the Brain Suggest Neurotropic Damage Neuropathological Features of Covid-19 Mechanisms of Stroke in COVID-19 Association of inflammatory markers with the severity of COVID-19: A meta-analysis Novel Coronavirus Disease 2019 and Subarachnoid Hemorrhage: A Case Report