key: cord-274849-awv8sp8m
authors: Iyengar, Karthikeyan P.; Ish, Pranav; Upadhyaya, Gaurav Kumar; Malhotra, Nipun; Vaishya, Raju; Jain, Vijay K.
title: COVID-19 and mortality in doctors
date: 2020-09-03
journal: Diabetes Metab Syndr
DOI: 10.1016/j.dsx.2020.09.003
sha: 
doc_id: 274849
cord_uid: awv8sp8m

BACKGROUND AND AIMS: COVID-19 disease appear to have been associated with significant mortality amongst doctors and health care workers globally. We explore the various risk factors associated with this occupational risk, especially focusing on India. This may elucidate lessons to protect these frontline workers during the COVID-19 pandemic. METHODS: We carried out a comprehensive review of the literature using suitable keywords such as ‘COVID-19’, ‘pandemics’, ‘physicians’ ‘mortality’ and ‘health personnel’ on the search engines of PubMed, SCOPUS, Google Scholar and ResearchGate in the month of July 2020 during the current COVID-19 pandemic and assessed mortality data. RESULTS: Mortality in health care professionals has been on the rise. The countries which faced the pandemic in the early months of 2020 have had a huge surge in mortality amongst doctors due to COVID-19. India continues to show a rising trend in COVID-19 cases, however although compared to the western world India has seen a comparatively favourable statistic. Male gender, elderly doctors and those belonging to Black, Asian, and Minority Ethnic (BAME) community seem to be predisposing factors in the western world. CONCLUSION: COVID-19 has been associated with an increased mortality in doctors and health care workers. Until an effective cure/vaccine is developed, risk assessments at work, mitigating confounding factors, adequate supply of personal protective equipment (PPE) and enhanced protection against infection are necessary to protect health care professionals on the coronavirus frontline. Otherwise this occupational risk can lead to further untimely mortality and become another unintended consequence of the COVID-19 pandemic.

The novel Coronavirus SARS-CoV-2 outbreak has created a significant impact on the daily life and health care systems across the world including India [1] [2] [3] . COVID-19 has caused a huge burden and loss to the world with doctors bearing the brunt of physical burnout, mental stress, occupational risk of infection with increased risk of morbidity and mortality, being the front-line workers. Currently India is the third worst affected country in the world with more than 2 million confirmed cases and above 43,000 deaths attributed to COVID-19 [4] . It has been observed that COVID-19 related mortality in the general population has been slightly lower in the South Asian subcontinent. [5] Concerns have been raised since nearly 200 doctors have succumbed to COVID-19 so far with a significant number of healthcare professionals affected as well. [6] The mortality of these doctors has made a dent in an already compromised health care system due to poor doctor patient ratio. The Indian Medical Association (IMA) National COVID-19 registry data suggests more than 1000 doctors have been infected with SARS-CoV-2 virus, where 75 % of them are above the age of 50 years.

[7] Doctors face multiple challenges while dealing with this pandemic-specially limited personal protective equipment (PPE), training, rest, and rotation but worst of all loss of life due to coronavirus infection [8, 9] . IMA has issued a 'Red Alert' and requested the health authorities to ensure adequate safety of all doctors along with support from state sponsored medical and life insurance facilities to all involved in the coronavirus containment efforts.

[10] We aim to explore the burden, the risk factors and lessons that can be learnt to protect these frontline workers.

As on date 15 April 2020; countries with the most reported physician deaths were from Italy 44%, Iran 15%, Philippines 8%, Indonesia 6%, China 6%, Spain 4%, USA 4%, and UK (11/278; 4%) [11] . Even though there is no global platform for assessing the mortality among doctors due to COVID-19, reported literature in the national media has raised concern (Table 1). Doctors account for 0.5 per cent of the total deaths in India due to Covid-19.There have been 196 reported deaths among doctors in India due to COVID-19 as reported by IMA over the last 6 months until August 2020 after reporting of the first COVID-19 case on 30 January 2020 [12, 13] . Developed nations in Europe, however, have had worse figures. Italy reported its 100th COVID-19 casualty amongst doctors back in April 2020 [14] . The reasons could be unpreparedness of these countries in terms of PPE, delayed implementation of social J o u r n a l P r e -p r o o f distancing and infection prevention strategies, and late lockdown in the early phase of the pandemic.

We have identified several risk factors that are associated with increased mortality amongst the healthcare workers and doctors.

1. Age and Gender-Yoshida reported 120 deaths of medical doctors up to 3 April 2020 in the early months of COVID-19 [15] . Out of them 94 were between 50-99 years of age with a median age of 65 years and 108 were males. No reason for this disparity has been described in the article. The results of other meta-analysis showed that 60% of the COVID-19 patients were male [16] . The reason for a disproportionate mortality in the male gender is unclear. Lack of hand hygiene may be a causative factor for increased prevalence of COVID-19 infection in males. Social roles of females in Asian countries like India such as cooking, house cleaning etc may sensitize females to having a different perspective towards hand hygiene. Higher rates of tobacco consumption, increased concentration of Angiotensin-converting enzyme 2 (ACE-2) in males as compared to females, a reluctance to seek proper and timely medical care and even lower rates of handwashing absolutely has been quoted to be few of the reasons [17] . As observed about the deaths amongst the general population most of fatality were seen among elderly male doctors [15] . The reasons postulated are these senior physicians had re-started to work during the earlier part of the pandemic when protection may have been insufficient, or they had associated co-morbidities.

COVID-19 [11] . Frontline doctors that deal with COVID-19 patients seem to bear the brunt of mortality rates. Deaths were noted to be more common among general practitioners or physicians, suggesting a higher risk of deaths among doctors who may have repeated encounters with COVID-19 patients [15] . Physicians from certain fields of medicine such as anaesthesiology, dentistry and otorhinolaryngology are more prone to acquire COVID-19 as their work involves intubation, oral/nasal or other aerosol generating procedures, which may place them at an increased risk and Table 1 seems to suggest that. 

preventive strategy against COVID-19 is a stringent and effective use of personal protective equipment (PPE). In early April, when the outbreak was exponentially increasing in magnitude in Europe, concerns regarding a lack of PPE were voiced by health care professionals across multiple countries in the continent [23, 24] . Soon, the lack of numbers of PPE was managed by development of effective reuse methods and an increase in the production capacity of PPE.

shown to have a significant bearing on the course of COVID-19 disease. It has been acknowledged that there is disproportionate mortality and morbidity amongst black, Asian and minority ethnic (BAME) people, including our National Health Service (NHS) staff, who have contracted COVID-19 [25, 26] . A large proportion of BAME healthcare workers were more severely affected by COVID-19 at the beginning of the pandemic succumbed to the disease. 94% of doctors who lost their lives were of a BAME background [27] . A multitude of confounding reasons including individual patient factors, genetic susceptibility, socio-economic factors, associated comorbidities have been postulated to suggest higher disease burden in BAME people including doctors with calls for urgent public health research priority in this discrepancy [28] .

include lack of adequate PPE, inadequate technique of donning and doffing, nondisclosure by patients of their exposure to possible COVID-19 excessive working hours and poor doctor-patient ratio. Certain comorbidities including advancing age, diabetes mellitus, cardiovascular diseases, chronic lung disease or immunocompromised states are also contributory [29] .

• India is a country with a large population where most of the patients seek treatment in government hospitals. The outpatients of these hospitals have been flooded with patients even during the lockdown period. It has been difficult to organise testing for COVID-19 of all patients visiting these hospitals. This could be another cause of exposure to the doctors from these patients. Most of the elderly doctors having comorbidities continued to do private practice without taking proper precautions succumbs to death in various states across India. In Bihar, the percentage of doctors' death is 4.75 per cent, which is nine times more than the national average. One of the reasons for more doctors' death in the Bihar state was doctor's work for more than J o u r n a l P r e -p r o o f longer days than the other states as the quarantine protocol of 15 days was not followed in managing covid19 patient and due to large number of vacant post of doctors; the elderly and comorbid doctors were forced to perform duty and got no relief. [30] • As such lack of COVID-19 safe facilities, resources, availability of appropriate PPE and lack of uniform application of infection prevention strategies remain cause of concerns and an occupational risk for health care professionals in India.

• However, cues have been taken with a stringent lockdown, creation of dedicated COVID facilities, indigenous production of PPE and sanitisers, enforced central health guidelines and protocols. Training of the health care workers on use of PPE and prevention of spread of infection has been carried out [31] .

• By the time India saw a substantial growth in COVID-19 patients, the production and import of PPE had already been ramped up in the country. However, even with this increased capacity, a shortage of PPE was expected in the country considering the population. The country's premier medical institute (All India Institute of Medical Science (AIIMS) Delhi, issued timely guidelines on the reuse of PPE [32] . These measures may have contributed significantly towards reducing the effect of PPE shortfall.

• Current data from the IMA (Table 1) suggests general practitioners, primary care physicians and emergency doctors dealing acute or active COVID-19 cases seem to be disproportionately affected. The IMA National registry is a good step forward and initiatives such by NHS England to launch an enquiry into excess BAME NHS deaths will help the world community to understand the mitigating factors leading to HCP deaths and take steps to protect them. [33] • All the health care workers and doctors should screen for Tuberculosis and a major comorbidity such as diabetes before start practicing or doing Covid-19 duties. As history of latent or active tuberculosis is an important risk factor for acquiring COVID-19 infection. [34, 35] Limitation of the Study COVID-19 is an evolving disease. There is lack of uniform database on morbidity and mortality statistics due to COVID-19 amongst doctors and health care workers globally. This 

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Supporting our BAME NHS people during and beyond COVID-19: an update

Tuberculosis in the era of COVID-19 in India

Tuberculosis and COVID-19 in India-double trouble! Indian J Tuberc