key: cord-270419-krrd074l
authors: Falkenhain‐López, Daniel; Sánchez‐Velázquez, Alba; López‐Valle, Alba; Ortiz‐Frutos, Francisco J.
title: SARS‐Coronavirus‐2 and acute urticaria
date: 2020-05-22
journal: Int J Dermatol
DOI: 10.1111/ijd.14950
sha: 
doc_id: 270419
cord_uid: krrd074l

nan

A 51-year-old otherwise healthy woman presented to the emergency department with a 3-day history of dry cough and arthralgias. Simultaneously, she developed widespread pruritic evanescent skin lesions (lasting <24 hours). The patient had not taken any medication before the onset of the symptoms. She had no recent contact with plants, chemicals, or topical products. She denied any urticarial lesions before, and no precipitating factors such as physical stimuli, cold, heat, or sun exposure were found. Review of systems was negative for diarrhea, dysphagia, or other suggestive symptoms of anaphylaxis.

Physical examination revealed multiple well-demarcated erythematous edematous papules and plaques located on the trunk (Fig. 1) , thighs, upper limbs, and predominantly on the facial area and dorsal aspects of bilateral hands (Fig. 2) . The patient did not present angioedema or bronchospasm, and there was no swelling of the tongue, uvula, or peritonsillar area.

Blood test showed lymphopenia and elevated C-reactive pro- The association between urticaria and infectious diseases has been discussed for more than 100 years. However, this association with virus infections has rarely been reported in the literature. The lack of reported cases is probably because of the difficulty in establishing a cause-and-effect relationship.

We report a case of a woman with no previous history of urti- We consider it important to emphasize that SARS-CoV-2 and acute urticaria may be associated. Furthermore, the skin lesions might appear before the onset of the main respiratory symptoms, occurring at the early phase of the infection as part of the clinical presentation of COVID-19.

Cutaneous manifestations in COVID-19: a first perspective

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A dermatologic manifestation of COVID-19: transient livedo reticularis

COVID-19 can present with a rash and be mistaken for Dengue

Urticarial eruption in COVID-19 infection

Association between urticaria and virus infections: a systematic review