key: cord-030636-wpjmwwpu
authors: nan
title: Dear Editor,
date: 2020-08-19
journal: J Infect
DOI: 10.1016/j.jinf.2020.08.023
sha: 
doc_id: 30636
cord_uid: wpjmwwpu

nan

Since December 2019, some hospitals in Wuhan City, Hubei Province, have successively found multiple cases of unexplained pneumonia which have now been confirmed as a new type of acute respiratory infection caused by a coronavirus infection. The coronavirus isolated from the lower respiratory tract has been named as COVID-19; it has presented an unprecedented challenge for the healthcare community across the world. Based on the rapid increase in the rate of human infection, the World Health Organization (WHO) has classified the COVID-19 outbreak as a pandemic. Respiratory involvement, presenting as mild flu-like illness to potentially lethal acute respiratory distress syndrome or fulminant pneumonia, is the dominant clinical manifestation of COVID-19. Unlike other respiratory diseases, mortality of COVID-19 increased with age while children were observed less susceptible to death. Despite the observation that elderly subjects are more susceptible to severe illness, probably due to underlying co-morbidities such as diabetes, hypertension, cardiovascular and cerebro-vascular diseases, 1,2 literature concerning geriatric patients with COVID-19 pneumonia remained very scant. Most of the studies are editorial commentaries 3 and the clinical studies including patients of varying ages admitted to hospital have only a slight highlight on the association between age and severity of clinical manifestation. [4] [5] [6] Further, the majority of data at the moment available often originating from Chinese surveys where elderly patients accounted only for a very limited part of the total. In particular, a paper recently published into your Journal by Wang et al. 2 observed a high fatality rate in the very first days after hospitalization (a median survival of 5 days), and another paper by Liu et al. 6 found a higher mortality rate in elderly than in young and middle-aged patients. However, both these studies considered as elderly patients those aged > 60 years old which is a very different population from that observed in Europe and in particular in Italy, where the elderly (aged > 80 years old) accounted for a large proportion of individuals with severe COVID-19 pneumonia.

In our cohort we included elderly subjects (> 80 years old) hospitalized for COVID-19 pneumonia at two North-Italy district hospitals from March 9 th to April 30 th 2020. We included in this analysis 118 consecutive patients; data on clinical and demographic characteristics, blood test results and COVID-19-related treatments were collected. Survival status and clinical data were compared with a control group of COVID-19 patients aged < 70 years (n=109). Survival analysis was done using a multilevel mixed-effects parametric survival model.

Sixty-eight patients aged > 80 years died (57.6%) after a median time of 4.5 days from admission to emergency department compared to 4 patients (3.7%) in the control group (median time to death in control group: 16.4 days). Table 1 summarizes demographic and clinical characteristics and serum biomarkers of inflammation of the two groups. Older patients were more likely to have lower BMI (24.4 vs 27.3, p<0.001), COPD (18.6% vs 3%, p<0.0001), earlier access to emergency department from disease presentation (4 vs 6.2 days, p=0.02) and prolonged hospital stay (26 vs 14 days, p<0.0001). On the contrary, gastrointestinal symptoms and fever at admission were significantly more frequent in younger subjects. Furthermore, elderly patients had higher white blood cells (11000/mm 3 vs 6700/mm 3 , p<0.0001), C-reactive protein (9.8 mg/dL vs 6.5 mg/dL, p=0.001), procalcitonin (0.27 md/dL vs 0.1 mg/dL, p<0.0001), LDH (416.5 mg/dL vs 297.6, p=0.01) and d-dimer levels (1100 mg/dL vs 386 mg/dL, p<0.0001) at admission. At survival analysis, higher d-dimer levels [HR 1.11 (1.03-1.2), p=0.004] at admission in the emergency department and the combined use of antivirals and hydroxichloroquine [HR 8.42 (2.53-27.98), p<0.0001] were independently associated to a higher risk of death.

At our knowledge, this is the first report that evaluated the outcome of COVID-19 pneumonia in subjects > 80 years old. In this subset, we observed a high mortality rate especially in the very first days after hospitalization, probably due to a more rapid disease progression. These findings confirmed those by Wang et al. 2 who observed a median survival of 5 days after admission. Elderly patients have higher levels of inflammatory blood tests at the time of admission in the emergency department; in particular, elevated d-dimer levels was an independent predictor of mortality, confirming the close correlation between this parameter and the severity of COVID-19 disease. Also the use of a treatment including both antivirals and hydroxychloroquine was associated with a higher risk of death. This detrimental effect of the combined treatment could be possibly due to drug-related side effects in the elderly population, but this hypothesis needs to be further confirmed in prospective studies.

In conclusion, our study confirms that the majority of elderly subjects with COVID-19 pneumonia have an unfavorable outcome, especially in the very first days after admission. We also confirm the high importance of d-dimer levels as predictors of mortality and that the treatment with antivirals and hidroxychloroquine is ineffective if not harmful in elderly individuals.

Analysis of epidemiological and clinical features in older patients with coronavirus disease 2019 (COVID-19) outside Wuhan

Coronavirus diseases 2019 in elderly patients: characteristics and prognostic factors based on 4 week follow-up

COVID-19 through the lens of gerontology

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

Clinical Characteristics of 138 Hospitalized Patients With

Novel Coronavirus-Infected Pneumonia in Wuhan, China

Clinical features of COVID-19 in elederly patients: a comparison with young and middle-aged patients

Table 1. Demographic and clinical characteristics and serum biomarkers of inflammation in subjects > 80 and < 70 years old

Authors are grateful to John Tremamondo and Aldo Bellini for their support. Our special thanks go to all nursing and medical colleagues in ASST Rhodense Hospitals.