id sid tid token lemma pos cord-356164-y778k3hs 1 1 key key NN cord-356164-y778k3hs 1 2 : : : cord-356164-y778k3hs 2 1 cord-356164-y778k3hs cord-356164-y778k3hs NNP cord-356164-y778k3hs 2 2 authors author NNS cord-356164-y778k3hs 2 3 : : : cord-356164-y778k3hs 2 4 Komiyama Komiyama NNP cord-356164-y778k3hs 2 5 , , , cord-356164-y778k3hs 2 6 Maki Maki NNP cord-356164-y778k3hs 2 7 ; ; : cord-356164-y778k3hs 2 8 Hasegawa Hasegawa NNP cord-356164-y778k3hs 2 9 , , , cord-356164-y778k3hs 2 10 Koji Koji NNP cord-356164-y778k3hs 2 11 title title NN cord-356164-y778k3hs 2 12 : : : cord-356164-y778k3hs 2 13 Smoking Smoking NNP cord-356164-y778k3hs 2 14 Cessation Cessation NNP cord-356164-y778k3hs 2 15 as as IN cord-356164-y778k3hs 2 16 a a DT cord-356164-y778k3hs 2 17 Public Public NNP cord-356164-y778k3hs 2 18 Health Health NNP cord-356164-y778k3hs 2 19 Measure measure NN cord-356164-y778k3hs 2 20 to to TO cord-356164-y778k3hs 2 21 Limit limit VB cord-356164-y778k3hs 2 22 the the DT cord-356164-y778k3hs 2 23 Coronavirus Coronavirus NNP cord-356164-y778k3hs 2 24 Disease Disease NNP cord-356164-y778k3hs 2 25 2019 2019 CD cord-356164-y778k3hs 2 26 Pandemic Pandemic NNP cord-356164-y778k3hs 2 27 date date NN cord-356164-y778k3hs 2 28 : : : cord-356164-y778k3hs 2 29 2020 2020 CD cord-356164-y778k3hs 2 30 - - HYPH cord-356164-y778k3hs 2 31 04 04 CD cord-356164-y778k3hs 2 32 - - HYPH cord-356164-y778k3hs 2 33 23 23 CD cord-356164-y778k3hs 2 34 journal journal NN cord-356164-y778k3hs 2 35 : : : cord-356164-y778k3hs 3 1 Eur Eur NNP cord-356164-y778k3hs 3 2 Cardiol Cardiol NNP cord-356164-y778k3hs 3 3 DOI DOI NNP cord-356164-y778k3hs 3 4 : : : cord-356164-y778k3hs 4 1 10.15420 10.15420 CD cord-356164-y778k3hs 4 2 / / SYM cord-356164-y778k3hs 4 3 ecr.2020.11 ecr.2020.11 CD cord-356164-y778k3hs 5 1 sha sha NNP cord-356164-y778k3hs 5 2 : : : cord-356164-y778k3hs 5 3 2f49580cc40f8a973e71503fd3b630cf40fea7d1 2f49580cc40f8a973e71503fd3b630cf40fea7d1 CD cord-356164-y778k3hs 5 4 doc_id doc_id CD cord-356164-y778k3hs 5 5 : : : cord-356164-y778k3hs 5 6 356164 356164 CD cord-356164-y778k3hs 5 7 cord_uid cord_uid NN cord-356164-y778k3hs 5 8 : : : cord-356164-y778k3hs 6 1 y778k3hs y778k3hs NNP cord-356164-y778k3hs 7 1 The the DT cord-356164-y778k3hs 7 2 novel novel JJ cord-356164-y778k3hs 7 3 coronavirus coronavirus NN cord-356164-y778k3hs 7 4 disease disease NN cord-356164-y778k3hs 7 5 2019 2019 CD cord-356164-y778k3hs 7 6 ( ( -LRB- cord-356164-y778k3hs 7 7 COVID-19 COVID-19 NNP cord-356164-y778k3hs 7 8 ) ) -RRB- cord-356164-y778k3hs 7 9 has have VBZ cord-356164-y778k3hs 7 10 already already RB cord-356164-y778k3hs 7 11 evolved evolve VBN cord-356164-y778k3hs 7 12 into into IN cord-356164-y778k3hs 7 13 a a DT cord-356164-y778k3hs 7 14 rapidly rapidly RB cord-356164-y778k3hs 7 15 expanding expand VBG cord-356164-y778k3hs 7 16 pandemic pandemic NN cord-356164-y778k3hs 7 17 . . . cord-356164-y778k3hs 8 1 Risk risk NN cord-356164-y778k3hs 8 2 factors factor NNS cord-356164-y778k3hs 8 3 for for IN cord-356164-y778k3hs 8 4 COVID-19 covid-19 CD cord-356164-y778k3hs 8 5 , , , cord-356164-y778k3hs 8 6 such such JJ cord-356164-y778k3hs 8 7 as as IN cord-356164-y778k3hs 8 8 cardiovascular cardiovascular JJ cord-356164-y778k3hs 8 9 disease disease NN cord-356164-y778k3hs 8 10 , , , cord-356164-y778k3hs 8 11 chronic chronic JJ cord-356164-y778k3hs 8 12 obstructive obstructive JJ cord-356164-y778k3hs 8 13 pulmonary pulmonary JJ cord-356164-y778k3hs 8 14 disease disease NN cord-356164-y778k3hs 8 15 and and CC cord-356164-y778k3hs 8 16 diabetes diabetes NN cord-356164-y778k3hs 8 17 , , , cord-356164-y778k3hs 8 18 are be VBP cord-356164-y778k3hs 8 19 all all DT cord-356164-y778k3hs 8 20 strongly strongly RB cord-356164-y778k3hs 8 21 associated associate VBN cord-356164-y778k3hs 8 22 with with IN cord-356164-y778k3hs 8 23 smoking smoking NN cord-356164-y778k3hs 8 24 habits habit NNS cord-356164-y778k3hs 8 25 . . . cord-356164-y778k3hs 9 1 The the DT cord-356164-y778k3hs 9 2 effects effect NNS cord-356164-y778k3hs 9 3 of of IN cord-356164-y778k3hs 9 4 cigarette cigarette NN cord-356164-y778k3hs 9 5 smoking smoking NN cord-356164-y778k3hs 9 6 on on IN cord-356164-y778k3hs 9 7 the the DT cord-356164-y778k3hs 9 8 transmission transmission NN cord-356164-y778k3hs 9 9 of of IN cord-356164-y778k3hs 9 10 the the DT cord-356164-y778k3hs 9 11 virus virus NN cord-356164-y778k3hs 9 12 and and CC cord-356164-y778k3hs 9 13 worsening worsening NN cord-356164-y778k3hs 9 14 of of IN cord-356164-y778k3hs 9 15 COVID-19 COVID-19 NNP cord-356164-y778k3hs 9 16 have have VBP cord-356164-y778k3hs 9 17 been be VBN cord-356164-y778k3hs 9 18 less less RBR cord-356164-y778k3hs 9 19 addressed address VBN cord-356164-y778k3hs 9 20 . . . cord-356164-y778k3hs 10 1 Emerging emerge VBG cord-356164-y778k3hs 10 2 data datum NNS cord-356164-y778k3hs 10 3 indicate indicate VBP cord-356164-y778k3hs 10 4 that that IN cord-356164-y778k3hs 10 5 smoking smoke VBG cord-356164-y778k3hs 10 6 history history NN cord-356164-y778k3hs 10 7 is be VBZ cord-356164-y778k3hs 10 8 the the DT cord-356164-y778k3hs 10 9 major major JJ cord-356164-y778k3hs 10 10 determinant determinant NN cord-356164-y778k3hs 10 11 of of IN cord-356164-y778k3hs 10 12 worsening worsen VBG cord-356164-y778k3hs 10 13 COVID-19 covid-19 JJ cord-356164-y778k3hs 10 14 outcomes outcome NNS cord-356164-y778k3hs 10 15 . . . cord-356164-y778k3hs 11 1 Smoking smoking NN cord-356164-y778k3hs 11 2 cessation cessation NN cord-356164-y778k3hs 11 3 recovers recover VBZ cord-356164-y778k3hs 11 4 airway airway NN cord-356164-y778k3hs 11 5 ciliary ciliary NN cord-356164-y778k3hs 11 6 clearance clearance NN cord-356164-y778k3hs 11 7 and and CC cord-356164-y778k3hs 11 8 immune immune JJ cord-356164-y778k3hs 11 9 function function NN cord-356164-y778k3hs 11 10 . . . cord-356164-y778k3hs 12 1 Thus thus RB cord-356164-y778k3hs 12 2 , , , cord-356164-y778k3hs 12 3 smoking smoke VBG cord-356164-y778k3hs 12 4 cessation cessation NN cord-356164-y778k3hs 12 5 awareness awareness NN cord-356164-y778k3hs 12 6 is be VBZ cord-356164-y778k3hs 12 7 strongly strongly RB cord-356164-y778k3hs 12 8 encouraged encourage VBN cord-356164-y778k3hs 12 9 as as IN cord-356164-y778k3hs 12 10 a a DT cord-356164-y778k3hs 12 11 public public JJ cord-356164-y778k3hs 12 12 health health NN cord-356164-y778k3hs 12 13 measure measure NN cord-356164-y778k3hs 12 14 to to TO cord-356164-y778k3hs 12 15 limit limit VB cord-356164-y778k3hs 12 16 the the DT cord-356164-y778k3hs 12 17 global global JJ cord-356164-y778k3hs 12 18 impact impact NN cord-356164-y778k3hs 12 19 of of IN cord-356164-y778k3hs 12 20 COVID-19 COVID-19 NNP cord-356164-y778k3hs 12 21 . . . cord-356164-y778k3hs 13 1 In in IN cord-356164-y778k3hs 13 2 a a DT cord-356164-y778k3hs 13 3 report report NN cord-356164-y778k3hs 13 4 on on IN cord-356164-y778k3hs 13 5 1,099 1,099 CD cord-356164-y778k3hs 13 6 infected infect VBN cord-356164-y778k3hs 13 7 individuals individual NNS cord-356164-y778k3hs 13 8 from from IN cord-356164-y778k3hs 13 9 China China NNP cord-356164-y778k3hs 13 10 , , , cord-356164-y778k3hs 13 11 12.4 12.4 CD cord-356164-y778k3hs 13 12 % % NN cord-356164-y778k3hs 13 13 of of IN cord-356164-y778k3hs 13 14 current current JJ cord-356164-y778k3hs 13 15 smokers smoker NNS cord-356164-y778k3hs 13 16 and and CC cord-356164-y778k3hs 13 17 23.8 23.8 CD cord-356164-y778k3hs 13 18 % % NN cord-356164-y778k3hs 13 19 of of IN cord-356164-y778k3hs 13 20 past past JJ cord-356164-y778k3hs 13 21 smokers smoker NNS cord-356164-y778k3hs 13 22 developed develop VBD cord-356164-y778k3hs 13 23 critical critical JJ cord-356164-y778k3hs 13 24 outcomes outcome NNS cord-356164-y778k3hs 13 25 , , , cord-356164-y778k3hs 13 26 including include VBG cord-356164-y778k3hs 13 27 being be VBG cord-356164-y778k3hs 13 28 admitted admit VBN cord-356164-y778k3hs 13 29 into into IN cord-356164-y778k3hs 13 30 an an DT cord-356164-y778k3hs 13 31 intensive intensive JJ cord-356164-y778k3hs 13 32 care care NN cord-356164-y778k3hs 13 33 unit unit NN cord-356164-y778k3hs 13 34 or or CC cord-356164-y778k3hs 13 35 fitted fit VBN cord-356164-y778k3hs 13 36 with with IN cord-356164-y778k3hs 13 37 a a DT cord-356164-y778k3hs 13 38 ventilator ventilator NN cord-356164-y778k3hs 13 39 , , , cord-356164-y778k3hs 13 40 or or CC cord-356164-y778k3hs 13 41 mortality mortality NN cord-356164-y778k3hs 13 42 . . . cord-356164-y778k3hs 14 1 In in IN cord-356164-y778k3hs 14 2 comparison comparison NN cord-356164-y778k3hs 14 3 , , , cord-356164-y778k3hs 14 4 only only RB cord-356164-y778k3hs 14 5 4.7 4.7 CD cord-356164-y778k3hs 14 6 % % NN cord-356164-y778k3hs 14 7 of of IN cord-356164-y778k3hs 14 8 those those DT cord-356164-y778k3hs 14 9 who who WP cord-356164-y778k3hs 14 10 had have VBD cord-356164-y778k3hs 14 11 never never RB cord-356164-y778k3hs 14 12 smoked smoke VBN cord-356164-y778k3hs 14 13 developed develop VBN cord-356164-y778k3hs 14 14 critical critical JJ cord-356164-y778k3hs 14 15 outcomes outcome NNS cord-356164-y778k3hs 14 16 . . . cord-356164-y778k3hs 15 1 11 11 CD cord-356164-y778k3hs 15 2 Additionally additionally RB cord-356164-y778k3hs 15 3 , , , cord-356164-y778k3hs 15 4 the the DT cord-356164-y778k3hs 15 5 proportion proportion NN cord-356164-y778k3hs 15 6 of of IN cord-356164-y778k3hs 15 7 patients patient NNS cord-356164-y778k3hs 15 8 with with IN cord-356164-y778k3hs 15 9 severe severe JJ cord-356164-y778k3hs 15 10 symptoms symptom NNS cord-356164-y778k3hs 15 11 was be VBD cord-356164-y778k3hs 15 12 21.2 21.2 CD cord-356164-y778k3hs 15 13 % % NN cord-356164-y778k3hs 15 14 among among IN cord-356164-y778k3hs 15 15 current current JJ cord-356164-y778k3hs 15 16 smokers smoker NNS cord-356164-y778k3hs 15 17 and and CC cord-356164-y778k3hs 15 18 42.9 42.9 CD cord-356164-y778k3hs 15 19 % % NN cord-356164-y778k3hs 15 20 among among IN cord-356164-y778k3hs 15 21 past past JJ cord-356164-y778k3hs 15 22 smokers smoker NNS cord-356164-y778k3hs 15 23 , , , cord-356164-y778k3hs 15 24 which which WDT cord-356164-y778k3hs 15 25 was be VBD cord-356164-y778k3hs 15 26 higher high JJR cord-356164-y778k3hs 15 27 compared compare VBN cord-356164-y778k3hs 15 28 with with IN cord-356164-y778k3hs 15 29 those those DT cord-356164-y778k3hs 15 30 who who WP cord-356164-y778k3hs 15 31 had have VBD cord-356164-y778k3hs 15 32 never never RB cord-356164-y778k3hs 15 33 smoked smoke VBN cord-356164-y778k3hs 15 34 ( ( -LRB- cord-356164-y778k3hs 15 35 14.5 14.5 CD cord-356164-y778k3hs 15 36 % % NN cord-356164-y778k3hs 15 37 ) ) -RRB- cord-356164-y778k3hs 15 38 . . . cord-356164-y778k3hs 16 1 11 11 CD cord-356164-y778k3hs 17 1 In in IN cord-356164-y778k3hs 17 2 this this DT cord-356164-y778k3hs 17 3 report report NN cord-356164-y778k3hs 17 4 , , , cord-356164-y778k3hs 17 5 the the DT cord-356164-y778k3hs 17 6 analysis analysis NN cord-356164-y778k3hs 17 7 was be VBD cord-356164-y778k3hs 17 8 just just RB cord-356164-y778k3hs 17 9 a a DT cord-356164-y778k3hs 17 10 simple simple JJ cord-356164-y778k3hs 17 11 comparison comparison NN cord-356164-y778k3hs 17 12 . . . cord-356164-y778k3hs 18 1 Usually usually RB cord-356164-y778k3hs 18 2 , , , cord-356164-y778k3hs 18 3 past past IN cord-356164-y778k3hs 18 4 smokers smoker NNS cord-356164-y778k3hs 18 5 were be VBD cord-356164-y778k3hs 18 6 older old JJR cord-356164-y778k3hs 18 7 than than IN cord-356164-y778k3hs 18 8 current current JJ cord-356164-y778k3hs 18 9 smokers smoker NNS cord-356164-y778k3hs 18 10 . . . cord-356164-y778k3hs 19 1 Therefore therefore RB cord-356164-y778k3hs 19 2 , , , cord-356164-y778k3hs 19 3 a a DT cord-356164-y778k3hs 19 4 high high JJ cord-356164-y778k3hs 19 5 age age NN cord-356164-y778k3hs 19 6 in in IN cord-356164-y778k3hs 19 7 past past JJ cord-356164-y778k3hs 19 8 smokers smoker NNS cord-356164-y778k3hs 19 9 may may MD cord-356164-y778k3hs 19 10 contribute contribute VB cord-356164-y778k3hs 19 11 to to IN cord-356164-y778k3hs 19 12 their -PRON- PRP$ cord-356164-y778k3hs 19 13 worsening worsen VBG cord-356164-y778k3hs 19 14 outcomes outcome NNS cord-356164-y778k3hs 19 15 . . . cord-356164-y778k3hs 20 1 A a DT cord-356164-y778k3hs 20 2 small small JJ cord-356164-y778k3hs 20 3 study study NN cord-356164-y778k3hs 20 4 from from IN cord-356164-y778k3hs 20 5 China China NNP cord-356164-y778k3hs 20 6 using use VBG cord-356164-y778k3hs 20 7 multivariate multivariate JJ cord-356164-y778k3hs 20 8 analysis analysis NN cord-356164-y778k3hs 20 9 identified identify VBD cord-356164-y778k3hs 20 10 the the DT cord-356164-y778k3hs 20 11 following follow VBG cord-356164-y778k3hs 20 12 four four CD cord-356164-y778k3hs 20 13 factors factor NNS cord-356164-y778k3hs 20 14 as as IN cord-356164-y778k3hs 20 15 being be VBG cord-356164-y778k3hs 20 16 associated associate VBN cord-356164-y778k3hs 20 17 with with IN cord-356164-y778k3hs 20 18 COVID-19 covid-19 JJ cord-356164-y778k3hs 20 19 deterioration deterioration NN cord-356164-y778k3hs 20 20 : : : cord-356164-y778k3hs 20 21 smoking smoke VBG cord-356164-y778k3hs 20 22 history history NN cord-356164-y778k3hs 20 23 , , , cord-356164-y778k3hs 20 24 body body NN cord-356164-y778k3hs 20 25 temperature temperature NN cord-356164-y778k3hs 20 26 of of IN cord-356164-y778k3hs 20 27 > > XX cord-356164-y778k3hs 20 28 37.3 37.3 CD cord-356164-y778k3hs 20 29 ° ° NN cord-356164-y778k3hs 20 30 C c NN cord-356164-y778k3hs 20 31 at at IN cord-356164-y778k3hs 20 32 the the DT cord-356164-y778k3hs 20 33 time time NN cord-356164-y778k3hs 20 34 of of IN cord-356164-y778k3hs 20 35 admission admission NN cord-356164-y778k3hs 20 36 , , , cord-356164-y778k3hs 20 37 respiratory respiratory JJ cord-356164-y778k3hs 20 38 failure failure NN cord-356164-y778k3hs 20 39 and and CC cord-356164-y778k3hs 20 40 age age NN cord-356164-y778k3hs 20 41 ≥60 ≥60 HYPH cord-356164-y778k3hs 20 42 years year NNS cord-356164-y778k3hs 20 43 . . . cord-356164-y778k3hs 21 1 12 12 CD cord-356164-y778k3hs 22 1 Among among IN cord-356164-y778k3hs 22 2 these these DT cord-356164-y778k3hs 22 3 , , , cord-356164-y778k3hs 22 4 the the DT cord-356164-y778k3hs 22 5 OR or CC cord-356164-y778k3hs 22 6 for for IN cord-356164-y778k3hs 22 7 smoking smoke VBG cord-356164-y778k3hs 22 8 history history NN cord-356164-y778k3hs 22 9 was be VBD cord-356164-y778k3hs 22 10 highest high JJS cord-356164-y778k3hs 22 11 at at IN cord-356164-y778k3hs 22 12 14 14 CD cord-356164-y778k3hs 23 1 ( ( -LRB- cord-356164-y778k3hs 23 2 CI CI NNP cord-356164-y778k3hs 23 3 [ [ -LRB- cord-356164-y778k3hs 23 4 1.6 1.6 CD cord-356164-y778k3hs 23 5 - - SYM cord-356164-y778k3hs 23 6 45 45 CD cord-356164-y778k3hs 23 7 ] ] -RRB- cord-356164-y778k3hs 23 8 ; ; : cord-356164-y778k3hs 24 1 p=0.018 p=0.018 NNP cord-356164-y778k3hs 24 2 ) ) -RRB- cord-356164-y778k3hs 24 3 , , , cord-356164-y778k3hs 24 4 which which WDT cord-356164-y778k3hs 24 5 was be VBD cord-356164-y778k3hs 24 6 higher high JJR cord-356164-y778k3hs 24 7 than than IN cord-356164-y778k3hs 24 8 the the DT cord-356164-y778k3hs 24 9 ORs or NNS cord-356164-y778k3hs 24 10 for for IN cord-356164-y778k3hs 24 11 other other JJ cord-356164-y778k3hs 24 12 factors factor NNS cord-356164-y778k3hs 24 13 associated associate VBN cord-356164-y778k3hs 24 14 with with IN cord-356164-y778k3hs 24 15 disease disease NN cord-356164-y778k3hs 24 16 deterioration deterioration NN cord-356164-y778k3hs 24 17 ( ( -LRB- cord-356164-y778k3hs 24 18 8.5 8.5 CD cord-356164-y778k3hs 24 19 - - SYM cord-356164-y778k3hs 24 20 9.0 9.0 CD cord-356164-y778k3hs 24 21 ) ) -RRB- cord-356164-y778k3hs 24 22 . . . cord-356164-y778k3hs 25 1 As as IN cord-356164-y778k3hs 25 2 noted note VBN cord-356164-y778k3hs 25 3 earlier early RBR cord-356164-y778k3hs 25 4 , , , cord-356164-y778k3hs 25 5 COVID-19 COVID-19 NNP cord-356164-y778k3hs 25 6 is be VBZ cord-356164-y778k3hs 25 7 considered consider VBN cord-356164-y778k3hs 25 8 to to TO cord-356164-y778k3hs 25 9 be be VB cord-356164-y778k3hs 25 10 severe severe JJ cord-356164-y778k3hs 25 11 and and CC cord-356164-y778k3hs 25 12 associated associate VBN cord-356164-y778k3hs 25 13 with with IN cord-356164-y778k3hs 25 14 a a DT cord-356164-y778k3hs 25 15 higher high JJR cord-356164-y778k3hs 25 16 mortality mortality NN cord-356164-y778k3hs 25 17 rate rate NN cord-356164-y778k3hs 25 18 in in IN cord-356164-y778k3hs 25 19 elderly elderly JJ cord-356164-y778k3hs 25 20 patients patient NNS cord-356164-y778k3hs 25 21 with with IN cord-356164-y778k3hs 25 22 underlying underlie VBG cord-356164-y778k3hs 25 23 diseases disease NNS cord-356164-y778k3hs 25 24 ; ; : cord-356164-y778k3hs 25 25 it -PRON- PRP cord-356164-y778k3hs 25 26 is be VBZ cord-356164-y778k3hs 25 27 worth worth JJ cord-356164-y778k3hs 25 28 noting note VBG cord-356164-y778k3hs 25 29 that that IN cord-356164-y778k3hs 25 30 underlying underlie VBG cord-356164-y778k3hs 25 31 diseases disease NNS cord-356164-y778k3hs 25 32 related relate VBN cord-356164-y778k3hs 25 33 to to IN cord-356164-y778k3hs 25 34 the the DT cord-356164-y778k3hs 25 35 severity severity NN cord-356164-y778k3hs 25 36 of of IN cord-356164-y778k3hs 25 37 COVID-19 COVID-19 NNP cord-356164-y778k3hs 25 38 , , , cord-356164-y778k3hs 25 39 such such JJ cord-356164-y778k3hs 25 40 as as IN cord-356164-y778k3hs 25 41 cardiovascular cardiovascular JJ cord-356164-y778k3hs 25 42 disease disease NN cord-356164-y778k3hs 25 43 , , , cord-356164-y778k3hs 25 44 chronic chronic JJ cord-356164-y778k3hs 25 45 obstructive obstructive JJ cord-356164-y778k3hs 25 46 pulmonary pulmonary JJ cord-356164-y778k3hs 25 47 disease disease NN cord-356164-y778k3hs 25 48 and and CC cord-356164-y778k3hs 25 49 diabetes diabetes NN cord-356164-y778k3hs 25 50 , , , cord-356164-y778k3hs 25 51 are be VBP cord-356164-y778k3hs 25 52 all all DT cord-356164-y778k3hs 25 53 strongly strongly RB cord-356164-y778k3hs 25 54 associated associate VBN cord-356164-y778k3hs 25 55 with with IN cord-356164-y778k3hs 25 56 smoking smoking NN cord-356164-y778k3hs 25 57 . . . cord-356164-y778k3hs 26 1 13 13 CD cord-356164-y778k3hs 26 2 , , , cord-356164-y778k3hs 26 3 14 14 CD cord-356164-y778k3hs 26 4 COVID-19 covid-19 NN cord-356164-y778k3hs 26 5 is be VBZ cord-356164-y778k3hs 26 6 primarily primarily RB cord-356164-y778k3hs 26 7 a a DT cord-356164-y778k3hs 26 8 disease disease NN cord-356164-y778k3hs 26 9 of of IN cord-356164-y778k3hs 26 10 the the DT cord-356164-y778k3hs 26 11 respiratory respiratory JJ cord-356164-y778k3hs 26 12 tract tract NN cord-356164-y778k3hs 26 13 , , , cord-356164-y778k3hs 26 14 and and CC cord-356164-y778k3hs 27 1 virus virus NN cord-356164-y778k3hs 27 2 entry entry NN cord-356164-y778k3hs 27 3 into into IN cord-356164-y778k3hs 27 4 cells cell NNS cord-356164-y778k3hs 27 5 , , , cord-356164-y778k3hs 27 6 viral viral JJ cord-356164-y778k3hs 27 7 replication replication NN cord-356164-y778k3hs 27 8 and and CC cord-356164-y778k3hs 27 9 virion virion NN cord-356164-y778k3hs 27 10 release release NN cord-356164-y778k3hs 27 11 occur occur VBP cord-356164-y778k3hs 27 12 within within IN cord-356164-y778k3hs 27 13 the the DT cord-356164-y778k3hs 27 14 respiratory respiratory JJ cord-356164-y778k3hs 27 15 tract tract NN cord-356164-y778k3hs 27 16 . . . cord-356164-y778k3hs 28 1 15 15 CD cord-356164-y778k3hs 28 2 Angiotensin angiotensin NN cord-356164-y778k3hs 28 3 - - HYPH cord-356164-y778k3hs 28 4 converting convert VBG cord-356164-y778k3hs 28 5 enzyme enzyme NN cord-356164-y778k3hs 28 6 ( ( -LRB- cord-356164-y778k3hs 28 7 ACE ace NN cord-356164-y778k3hs 28 8 ) ) -RRB- cord-356164-y778k3hs 28 9 2 2 CD cord-356164-y778k3hs 28 10 converts convert VBZ cord-356164-y778k3hs 28 11 the the DT cord-356164-y778k3hs 28 12 vasoconstrictor vasoconstrictor NN cord-356164-y778k3hs 28 13 angiotensin angiotensin NN cord-356164-y778k3hs 28 14 II II NNP cord-356164-y778k3hs 28 15 to to IN cord-356164-y778k3hs 28 16 vasoprotective vasoprotective NNP cord-356164-y778k3hs 28 17 angiotensin angiotensin NNP cord-356164-y778k3hs 28 18 . . . cord-356164-y778k3hs 29 1 [ [ -LRB- cord-356164-y778k3hs 29 2 1 1 CD cord-356164-y778k3hs 29 3 ] ] -RRB- cord-356164-y778k3hs 29 4 [ [ -LRB- cord-356164-y778k3hs 29 5 2 2 CD cord-356164-y778k3hs 29 6 ] ] -RRB- cord-356164-y778k3hs 29 7 [ [ -LRB- cord-356164-y778k3hs 29 8 3 3 CD cord-356164-y778k3hs 29 9 ] ] -RRB- cord-356164-y778k3hs 29 10 [ [ -LRB- cord-356164-y778k3hs 29 11 4 4 CD cord-356164-y778k3hs 29 12 ] ] -RRB- cord-356164-y778k3hs 29 13 [ [ -LRB- cord-356164-y778k3hs 29 14 5 5 CD cord-356164-y778k3hs 29 15 ] ] -RRB- cord-356164-y778k3hs 29 16 [ [ -LRB- cord-356164-y778k3hs 29 17 6 6 CD cord-356164-y778k3hs 29 18 ] ] -RRB- cord-356164-y778k3hs 29 19 [ [ -LRB- cord-356164-y778k3hs 29 20 7 7 CD cord-356164-y778k3hs 29 21 ] ] -RRB- cord-356164-y778k3hs 30 1 Multiple multiple JJ cord-356164-y778k3hs 30 2 studies study NNS cord-356164-y778k3hs 30 3 have have VBP cord-356164-y778k3hs 30 4 shown show VBN cord-356164-y778k3hs 30 5 that that IN cord-356164-y778k3hs 30 6 ACE-2 ACE-2 NNP cord-356164-y778k3hs 30 7 is be VBZ cord-356164-y778k3hs 30 8 a a DT cord-356164-y778k3hs 30 9 host host NN cord-356164-y778k3hs 30 10 receptor receptor NN cord-356164-y778k3hs 30 11 for for IN cord-356164-y778k3hs 30 12 SARS SARS NNP cord-356164-y778k3hs 30 13 - - HYPH cord-356164-y778k3hs 30 14 CoV-2 CoV-2 NNP cord-356164-y778k3hs 30 15 . . . cord-356164-y778k3hs 31 1 16 16 CD cord-356164-y778k3hs 31 2 SARS SARS NNP cord-356164-y778k3hs 31 3 - - HYPH cord-356164-y778k3hs 31 4 CoV-2 CoV-2 NNP cord-356164-y778k3hs 31 5 enters enter VBZ cord-356164-y778k3hs 31 6 cells cell NNS cord-356164-y778k3hs 31 7 through through IN cord-356164-y778k3hs 31 8 ACE-2 ACE-2 NNP cord-356164-y778k3hs 31 9 receptors receptor NNS cord-356164-y778k3hs 31 10 present present JJ cord-356164-y778k3hs 31 11 in in IN cord-356164-y778k3hs 31 12 mucosal mucosal JJ cord-356164-y778k3hs 31 13 epithelial epithelial JJ cord-356164-y778k3hs 31 14 cells cell NNS cord-356164-y778k3hs 31 15 and and CC cord-356164-y778k3hs 31 16 alveolar alveolar JJ cord-356164-y778k3hs 31 17 tissues tissue NNS cord-356164-y778k3hs 31 18 in in IN cord-356164-y778k3hs 31 19 a a DT cord-356164-y778k3hs 31 20 clathrin clathrin NN cord-356164-y778k3hs 31 21 - - HYPH cord-356164-y778k3hs 31 22 dependent dependent JJ cord-356164-y778k3hs 31 23 process process NN cord-356164-y778k3hs 31 24 . . . cord-356164-y778k3hs 32 1 Cigarette cigarette NN cord-356164-y778k3hs 32 2 smoking smoking NN cord-356164-y778k3hs 32 3 increases increase VBZ cord-356164-y778k3hs 32 4 the the DT cord-356164-y778k3hs 32 5 expression expression NN cord-356164-y778k3hs 32 6 of of IN cord-356164-y778k3hs 32 7 ACE-2 ACE-2 NNP cord-356164-y778k3hs 32 8 in in IN cord-356164-y778k3hs 32 9 pulmonary pulmonary JJ cord-356164-y778k3hs 32 10 tissues tissue NNS cord-356164-y778k3hs 32 11 , , , cord-356164-y778k3hs 32 12 which which WDT cord-356164-y778k3hs 32 13 could could MD cord-356164-y778k3hs 32 14 in in IN cord-356164-y778k3hs 32 15 part part NN cord-356164-y778k3hs 32 16 account account NN cord-356164-y778k3hs 32 17 for for IN cord-356164-y778k3hs 32 18 the the DT cord-356164-y778k3hs 32 19 increased increase VBN cord-356164-y778k3hs 32 20 risk risk NN cord-356164-y778k3hs 32 21 of of IN cord-356164-y778k3hs 32 22 infection infection NN cord-356164-y778k3hs 32 23 . . . cord-356164-y778k3hs 33 1 17 17 CD cord-356164-y778k3hs 33 2 , , , cord-356164-y778k3hs 33 3 18 18 CD cord-356164-y778k3hs 33 4 Additionally additionally RB cord-356164-y778k3hs 33 5 , , , cord-356164-y778k3hs 33 6 the the DT cord-356164-y778k3hs 33 7 WHO who WP cord-356164-y778k3hs 33 8 has have VBZ cord-356164-y778k3hs 33 9 noted note VBN cord-356164-y778k3hs 33 10 that that IN cord-356164-y778k3hs 33 11 smokers smoker NNS cord-356164-y778k3hs 33 12 perform perform VBP cord-356164-y778k3hs 33 13 repeated repeat VBN cord-356164-y778k3hs 33 14 hand hand NN cord-356164-y778k3hs 33 15 to to TO cord-356164-y778k3hs 33 16 face face VB cord-356164-y778k3hs 33 17 reciprocal reciprocal JJ cord-356164-y778k3hs 33 18 movements movement NNS cord-356164-y778k3hs 33 19 , , , cord-356164-y778k3hs 33 20 which which WDT cord-356164-y778k3hs 33 21 contribute contribute VBP cord-356164-y778k3hs 33 22 to to IN cord-356164-y778k3hs 33 23 increased increase VBN cord-356164-y778k3hs 33 24 opportunity opportunity NN cord-356164-y778k3hs 33 25 for for IN cord-356164-y778k3hs 33 26 virus virus NN cord-356164-y778k3hs 33 27 entry entry NN cord-356164-y778k3hs 33 28 . . . cord-356164-y778k3hs 34 1 19 19 CD cord-356164-y778k3hs 34 2 ACE ACE NNP cord-356164-y778k3hs 34 3 inhibitors inhibitor NNS cord-356164-y778k3hs 34 4 and and CC cord-356164-y778k3hs 34 5 angiotensin angiotensin NN cord-356164-y778k3hs 34 6 - - HYPH cord-356164-y778k3hs 34 7 receptor receptor NN cord-356164-y778k3hs 34 8 blockers blocker NNS cord-356164-y778k3hs 34 9 also also RB cord-356164-y778k3hs 34 10 increase increase VBP cord-356164-y778k3hs 34 11 the the DT cord-356164-y778k3hs 34 12 expression expression NN cord-356164-y778k3hs 34 13 of of IN cord-356164-y778k3hs 34 14 ACE-2 ACE-2 NNP cord-356164-y778k3hs 34 15 receptors receptor NNS cord-356164-y778k3hs 34 16 , , , cord-356164-y778k3hs 34 17 which which WDT cord-356164-y778k3hs 34 18 could could MD cord-356164-y778k3hs 34 19 increase increase VB cord-356164-y778k3hs 34 20 the the DT cord-356164-y778k3hs 34 21 risk risk NN cord-356164-y778k3hs 34 22 of of IN cord-356164-y778k3hs 34 23 COVID-19 covid-19 JJ cord-356164-y778k3hs 34 24 infection infection NN cord-356164-y778k3hs 34 25 . . . cord-356164-y778k3hs 35 1 In in IN cord-356164-y778k3hs 35 2 fact fact NN cord-356164-y778k3hs 35 3 , , , cord-356164-y778k3hs 35 4 the the DT cord-356164-y778k3hs 35 5 ECDC ECDC NNP cord-356164-y778k3hs 35 6 reported report VBD cord-356164-y778k3hs 35 7 that that IN cord-356164-y778k3hs 35 8 74 74 CD cord-356164-y778k3hs 35 9 % % NN cord-356164-y778k3hs 35 10 of of IN cord-356164-y778k3hs 35 11 COVID-19 covid-19 JJ cord-356164-y778k3hs 35 12 fatalities fatality NNS cord-356164-y778k3hs 35 13 in in IN cord-356164-y778k3hs 35 14 Italy Italy NNP cord-356164-y778k3hs 35 15 had have VBD cord-356164-y778k3hs 35 16 concomitant concomitant JJ cord-356164-y778k3hs 35 17 hypertension hypertension NN cord-356164-y778k3hs 35 18 , , , cord-356164-y778k3hs 35 19 suggesting suggest VBG cord-356164-y778k3hs 35 20 an an DT cord-356164-y778k3hs 35 21 association association NN cord-356164-y778k3hs 35 22 with with IN cord-356164-y778k3hs 35 23 these these DT cord-356164-y778k3hs 35 24 drugs drug NNS cord-356164-y778k3hs 35 25 . . . cord-356164-y778k3hs 36 1 10 10 CD cord-356164-y778k3hs 37 1 Many many JJ cord-356164-y778k3hs 37 2 societies society NNS cord-356164-y778k3hs 37 3 , , , cord-356164-y778k3hs 37 4 including include VBG cord-356164-y778k3hs 37 5 the the DT cord-356164-y778k3hs 37 6 European European NNP cord-356164-y778k3hs 37 7 Society Society NNP cord-356164-y778k3hs 37 8 of of IN cord-356164-y778k3hs 37 9 Cardiology Cardiology NNP cord-356164-y778k3hs 37 10 , , , cord-356164-y778k3hs 37 11 have have VBP cord-356164-y778k3hs 37 12 issued issue VBN cord-356164-y778k3hs 37 13 alerts alert NNS cord-356164-y778k3hs 37 14 that that IN cord-356164-y778k3hs 37 15 patients patient NNS cord-356164-y778k3hs 37 16 with with IN cord-356164-y778k3hs 37 17 cardiovascular cardiovascular JJ cord-356164-y778k3hs 37 18 diseases disease NNS cord-356164-y778k3hs 37 19 discontinue discontinue VBP cord-356164-y778k3hs 37 20 ACE ace NN cord-356164-y778k3hs 37 21 inhibitors inhibitor NNS cord-356164-y778k3hs 37 22 and and CC cord-356164-y778k3hs 37 23 angiotensinreceptor angiotensinreceptor NN cord-356164-y778k3hs 37 24 blockers blocker NNS cord-356164-y778k3hs 37 25 . . . cord-356164-y778k3hs 38 1 20 20 CD cord-356164-y778k3hs 38 2 Switching switch VBG cord-356164-y778k3hs 38 3 to to IN cord-356164-y778k3hs 38 4 calcium calcium NN cord-356164-y778k3hs 38 5 antagonists antagonist NNS cord-356164-y778k3hs 38 6 has have VBZ cord-356164-y778k3hs 38 7 been be VBN cord-356164-y778k3hs 38 8 suggested suggest VBN cord-356164-y778k3hs 38 9 ; ; : cord-356164-y778k3hs 38 10 however however RB cord-356164-y778k3hs 38 11 , , , cord-356164-y778k3hs 38 12 further further JJ cord-356164-y778k3hs 38 13 evidence evidence NN cord-356164-y778k3hs 38 14 for for IN cord-356164-y778k3hs 38 15 this this DT cord-356164-y778k3hs 38 16 is be VBZ cord-356164-y778k3hs 38 17 needed need VBN cord-356164-y778k3hs 38 18 . . . cord-356164-y778k3hs 39 1 21 21 CD cord-356164-y778k3hs 40 1 Although although IN cord-356164-y778k3hs 40 2 only only RB cord-356164-y778k3hs 40 3 a a DT cord-356164-y778k3hs 40 4 few few JJ cord-356164-y778k3hs 40 5 reports report NNS cord-356164-y778k3hs 40 6 on on IN cord-356164-y778k3hs 40 7 smoking smoking NN cord-356164-y778k3hs 40 8 have have VBP cord-356164-y778k3hs 40 9 been be VBN cord-356164-y778k3hs 40 10 published publish VBN cord-356164-y778k3hs 40 11 to to IN cord-356164-y778k3hs 40 12 date date NN cord-356164-y778k3hs 40 13 and and CC cord-356164-y778k3hs 40 14 further further JJ cord-356164-y778k3hs 40 15 accrual accrual NN cord-356164-y778k3hs 40 16 of of IN cord-356164-y778k3hs 40 17 evidence evidence NN cord-356164-y778k3hs 40 18 is be VBZ cord-356164-y778k3hs 40 19 warranted warrant VBN cord-356164-y778k3hs 40 20 , , , cord-356164-y778k3hs 40 21 smoking smoking NN cord-356164-y778k3hs 40 22 is be VBZ cord-356164-y778k3hs 40 23 likely likely JJ cord-356164-y778k3hs 40 24 to to TO cord-356164-y778k3hs 40 25 be be VB cord-356164-y778k3hs 40 26 an an DT cord-356164-y778k3hs 40 27 important important JJ cord-356164-y778k3hs 40 28 and and CC cord-356164-y778k3hs 40 29 significant significant JJ cord-356164-y778k3hs 40 30 factor factor NN cord-356164-y778k3hs 40 31 associated associate VBN cord-356164-y778k3hs 40 32 with with IN cord-356164-y778k3hs 40 33 COVID-19 covid-19 JJ cord-356164-y778k3hs 40 34 severity severity NN cord-356164-y778k3hs 40 35 . . . cord-356164-y778k3hs 41 1 Cigarette cigarette NN cord-356164-y778k3hs 41 2 smoking smoking NN cord-356164-y778k3hs 41 3 decreases decrease VBZ cord-356164-y778k3hs 41 4 lung lung NN cord-356164-y778k3hs 41 5 function function NN cord-356164-y778k3hs 41 6 , , , cord-356164-y778k3hs 41 7 and and CC cord-356164-y778k3hs 41 8 evidently evidently RB cord-356164-y778k3hs 41 9 poses pose VBZ cord-356164-y778k3hs 41 10 a a DT cord-356164-y778k3hs 41 11 general general JJ cord-356164-y778k3hs 41 12 risk risk NN cord-356164-y778k3hs 41 13 factor factor NN cord-356164-y778k3hs 41 14 for for IN cord-356164-y778k3hs 41 15 severe severe JJ cord-356164-y778k3hs 41 16 respiratory respiratory JJ cord-356164-y778k3hs 41 17 infections infection NNS cord-356164-y778k3hs 41 18 , , , cord-356164-y778k3hs 41 19 thus thus RB cord-356164-y778k3hs 41 20 there there EX cord-356164-y778k3hs 41 21 is be VBZ cord-356164-y778k3hs 41 22 an an DT cord-356164-y778k3hs 41 23 apparent apparent JJ cord-356164-y778k3hs 41 24 association association NN cord-356164-y778k3hs 41 25 between between IN cord-356164-y778k3hs 41 26 cigarette cigarette NN cord-356164-y778k3hs 41 27 smoking smoking NN cord-356164-y778k3hs 41 28 and and CC cord-356164-y778k3hs 41 29 COVID-19 covid-19 JJ cord-356164-y778k3hs 41 30 severity severity NN cord-356164-y778k3hs 41 31 . . . cord-356164-y778k3hs 42 1 The the DT cord-356164-y778k3hs 42 2 detailed detailed JJ cord-356164-y778k3hs 42 3 mechanism mechanism NN cord-356164-y778k3hs 42 4 by by IN cord-356164-y778k3hs 42 5 which which WDT cord-356164-y778k3hs 42 6 COVID-19 COVID-19 NNP cord-356164-y778k3hs 42 7 becomes become VBZ cord-356164-y778k3hs 42 8 more more RBR cord-356164-y778k3hs 42 9 severe severe JJ cord-356164-y778k3hs 42 10 in in IN cord-356164-y778k3hs 42 11 patients patient NNS cord-356164-y778k3hs 42 12 with with IN cord-356164-y778k3hs 42 13 a a DT cord-356164-y778k3hs 42 14 history history NN cord-356164-y778k3hs 42 15 of of IN cord-356164-y778k3hs 42 16 cigarette cigarette NN cord-356164-y778k3hs 42 17 smoking smoking NN cord-356164-y778k3hs 42 18 warrants warrant NNS cord-356164-y778k3hs 42 19 further further JJ cord-356164-y778k3hs 42 20 investigation investigation NN cord-356164-y778k3hs 42 21 . . . cord-356164-y778k3hs 43 1 There there EX cord-356164-y778k3hs 43 2 is be VBZ cord-356164-y778k3hs 43 3 also also RB cord-356164-y778k3hs 43 4 a a DT cord-356164-y778k3hs 43 5 need need NN cord-356164-y778k3hs 43 6 for for IN cord-356164-y778k3hs 43 7 more more JJR cord-356164-y778k3hs 43 8 evidence evidence NN cord-356164-y778k3hs 43 9 on on IN cord-356164-y778k3hs 43 10 the the DT cord-356164-y778k3hs 43 11 effect effect NN cord-356164-y778k3hs 43 12 of of IN cord-356164-y778k3hs 43 13 second second JJ cord-356164-y778k3hs 43 14 - - HYPH cord-356164-y778k3hs 43 15 hand hand NN cord-356164-y778k3hs 43 16 smoke smoke NN cord-356164-y778k3hs 43 17 on on IN cord-356164-y778k3hs 43 18 the the DT cord-356164-y778k3hs 43 19 spread spread NN cord-356164-y778k3hs 43 20 of of IN cord-356164-y778k3hs 43 21 SARS SARS NNP cord-356164-y778k3hs 43 22 - - HYPH cord-356164-y778k3hs 43 23 CoV-2 CoV-2 NNP cord-356164-y778k3hs 43 24 . . . cord-356164-y778k3hs 44 1 However however RB cord-356164-y778k3hs 44 2 , , , cord-356164-y778k3hs 44 3 according accord VBG cord-356164-y778k3hs 44 4 to to IN cord-356164-y778k3hs 44 5 published publish VBN cord-356164-y778k3hs 44 6 COVID-19 COVID-19 NNP cord-356164-y778k3hs 44 7 research research NN cord-356164-y778k3hs 44 8 reports report NNS cord-356164-y778k3hs 44 9 , , , cord-356164-y778k3hs 44 10 even even RB cord-356164-y778k3hs 44 11 at at IN cord-356164-y778k3hs 44 12 this this DT cord-356164-y778k3hs 44 13 stage stage NN cord-356164-y778k3hs 44 14 , , , cord-356164-y778k3hs 44 15 it -PRON- PRP cord-356164-y778k3hs 44 16 might may MD cord-356164-y778k3hs 44 17 be be VB cord-356164-y778k3hs 44 18 well well RB cord-356164-y778k3hs 44 19 assumed assume VBN cord-356164-y778k3hs 44 20 that that IN cord-356164-y778k3hs 44 21 smokers smoker NNS cord-356164-y778k3hs 44 22 are be VBP cord-356164-y778k3hs 44 23 likely likely JJ cord-356164-y778k3hs 44 24 to to TO cord-356164-y778k3hs 44 25 be be VB cord-356164-y778k3hs 44 26 at at IN cord-356164-y778k3hs 44 27 serious serious JJ cord-356164-y778k3hs 44 28 risk risk NN cord-356164-y778k3hs 44 29 for for IN cord-356164-y778k3hs 44 30 contracting contract VBG cord-356164-y778k3hs 44 31 SARS SARS NNP cord-356164-y778k3hs 44 32 - - HYPH cord-356164-y778k3hs 44 33 CoV-2 CoV-2 NNP cord-356164-y778k3hs 44 34 infection infection NN cord-356164-y778k3hs 44 35 . . . cord-356164-y778k3hs 45 1 Smoking smoking NN cord-356164-y778k3hs 45 2 cessation cessation NN cord-356164-y778k3hs 45 3 recovers recover VBZ cord-356164-y778k3hs 45 4 airway airway NN cord-356164-y778k3hs 45 5 ciliary ciliary NN cord-356164-y778k3hs 45 6 clearance clearance NN cord-356164-y778k3hs 45 7 and and CC cord-356164-y778k3hs 45 8 immune immune JJ cord-356164-y778k3hs 45 9 function function NN cord-356164-y778k3hs 45 10 as as RB cord-356164-y778k3hs 45 11 early early RB cord-356164-y778k3hs 45 12 as as IN cord-356164-y778k3hs 45 13 1 1 CD cord-356164-y778k3hs 45 14 month month NN cord-356164-y778k3hs 45 15 . . . cord-356164-y778k3hs 46 1 Thus thus RB cord-356164-y778k3hs 46 2 , , , cord-356164-y778k3hs 46 3 smoking smoke VBG cord-356164-y778k3hs 46 4 cessation cessation NN cord-356164-y778k3hs 46 5 awareness awareness NN cord-356164-y778k3hs 46 6 is be VBZ cord-356164-y778k3hs 46 7 strongly strongly RB cord-356164-y778k3hs 46 8 encouraged encourage VBN cord-356164-y778k3hs 46 9 as as IN cord-356164-y778k3hs 46 10 part part NN cord-356164-y778k3hs 46 11 of of IN cord-356164-y778k3hs 46 12 public public JJ cord-356164-y778k3hs 46 13 health health NN cord-356164-y778k3hs 46 14 measures measure NNS cord-356164-y778k3hs 46 15 to to TO cord-356164-y778k3hs 46 16 limit limit VB cord-356164-y778k3hs 46 17 the the DT cord-356164-y778k3hs 46 18 global global JJ cord-356164-y778k3hs 46 19 impact impact NN cord-356164-y778k3hs 46 20 of of IN cord-356164-y778k3hs 46 21 COVID-19 COVID-19 NNP cord-356164-y778k3hs 46 22 . . . cord-356164-y778k3hs 47 1 WHO who WP cord-356164-y778k3hs 47 2 . . . cord-356164-y778k3hs 48 1 Coronavirus Coronavirus NNP cord-356164-y778k3hs 48 2 disease disease NN cord-356164-y778k3hs 48 3 ( ( -LRB- cord-356164-y778k3hs 48 4 COVID-19 COVID-19 NNP cord-356164-y778k3hs 48 5 ) ) -RRB- cord-356164-y778k3hs 48 6 outbreak outbreak NN cord-356164-y778k3hs 48 7 . . . cord-356164-y778k3hs 49 1 Geneva Geneva NNP cord-356164-y778k3hs 49 2 : : : cord-356164-y778k3hs 49 3 WHO who WP cord-356164-y778k3hs 49 4 , , , cord-356164-y778k3hs 49 5 2020 2020 CD cord-356164-y778k3hs 49 6 Cigarette cigarette NN cord-356164-y778k3hs 49 7 smoke smoke NN cord-356164-y778k3hs 49 8 alters alter VBZ cord-356164-y778k3hs 49 9 respiratory respiratory JJ cord-356164-y778k3hs 49 10 syncytial syncytial JJ cord-356164-y778k3hs 49 11 virus virus NN cord-356164-y778k3hs 49 12 - - HYPH cord-356164-y778k3hs 49 13 induced induce VBN cord-356164-y778k3hs 49 14 apoptosis apoptosis NN cord-356164-y778k3hs 49 15 and and CC cord-356164-y778k3hs 49 16 replication replication NN cord-356164-y778k3hs 49 17 Cigarette cigarette NN cord-356164-y778k3hs 49 18 smoking smoking NN cord-356164-y778k3hs 49 19 and and CC cord-356164-y778k3hs 49 20 infection infection NN cord-356164-y778k3hs 49 21 MERS MERS NNP cord-356164-y778k3hs 49 22 transmission transmission NN cord-356164-y778k3hs 49 23 and and CC cord-356164-y778k3hs 49 24 risk risk NN cord-356164-y778k3hs 49 25 factors factor NNS cord-356164-y778k3hs 49 26 : : : cord-356164-y778k3hs 49 27 a a DT cord-356164-y778k3hs 49 28 systematic systematic JJ cord-356164-y778k3hs 49 29 review review NN cord-356164-y778k3hs 49 30 Suppression suppression NN cord-356164-y778k3hs 49 31 of of IN cord-356164-y778k3hs 49 32 human human JJ cord-356164-y778k3hs 49 33 IL-1β il-1β NN cord-356164-y778k3hs 49 34 , , . cord-356164-y778k3hs 50 1 IL-2 IL-2 NNP cord-356164-y778k3hs 50 2 , , , cord-356164-y778k3hs 50 3 IFN IFN NNP cord-356164-y778k3hs 50 4 - - HYPH cord-356164-y778k3hs 50 5 γ γ NNP cord-356164-y778k3hs 50 6 , , , cord-356164-y778k3hs 50 7 and and CC cord-356164-y778k3hs 50 8 TNF TNF NNP cord-356164-y778k3hs 50 9 - - HYPH cord-356164-y778k3hs 50 10 α α NN cord-356164-y778k3hs 50 11 production production NN cord-356164-y778k3hs 50 12 by by IN cord-356164-y778k3hs 50 13 cigarette cigarette NN cord-356164-y778k3hs 50 14 smoke smoke NN cord-356164-y778k3hs 50 15 extracts extract VBZ cord-356164-y778k3hs 50 16 Evidence evidence NN cord-356164-y778k3hs 50 17 for for IN cord-356164-y778k3hs 50 18 the the DT cord-356164-y778k3hs 50 19 immunosuppressive immunosuppressive JJ cord-356164-y778k3hs 50 20 role role NN cord-356164-y778k3hs 50 21 of of IN cord-356164-y778k3hs 50 22 nicotine nicotine NN cord-356164-y778k3hs 50 23 on on IN cord-356164-y778k3hs 50 24 human human JJ cord-356164-y778k3hs 50 25 dendritic dendritic JJ cord-356164-y778k3hs 50 26 cell cell NN cord-356164-y778k3hs 50 27 functions function NNS cord-356164-y778k3hs 50 28 Nicotine Nicotine NNP cord-356164-y778k3hs 50 29 impairs impair VBZ cord-356164-y778k3hs 50 30 the the DT cord-356164-y778k3hs 50 31 response response NN cord-356164-y778k3hs 50 32 on on IN cord-356164-y778k3hs 50 33 lung lung NN cord-356164-y778k3hs 50 34 epithelial epithelial JJ cord-356164-y778k3hs 50 35 cells cell NNS cord-356164-y778k3hs 50 36 to to IN cord-356164-y778k3hs 50 37 IL-22 IL-22 NNP cord-356164-y778k3hs 50 38 Report Report NNP cord-356164-y778k3hs 50 39 of of IN cord-356164-y778k3hs 50 40 the the DT cord-356164-y778k3hs 50 41 WHO WHO NNP cord-356164-y778k3hs 50 42 - - HYPH cord-356164-y778k3hs 50 43 China China NNP cord-356164-y778k3hs 50 44 Joint Joint NNP cord-356164-y778k3hs 50 45 Mission Mission NNP cord-356164-y778k3hs 50 46 on on IN cord-356164-y778k3hs 50 47 Coronavirus Coronavirus NNP cord-356164-y778k3hs 50 48 Disease Disease NNP cord-356164-y778k3hs 50 49 2019 2019 CD cord-356164-y778k3hs 50 50 ( ( -LRB- cord-356164-y778k3hs 50 51 COVID-19 COVID-19 NNP cord-356164-y778k3hs 50 52 ) ) -RRB- cord-356164-y778k3hs 50 53 WHO who WP cord-356164-y778k3hs 50 54 . . . cord-356164-y778k3hs 51 1 WHO who WP cord-356164-y778k3hs 51 2 report report VBP cord-356164-y778k3hs 51 3 on on IN cord-356164-y778k3hs 51 4 the the DT cord-356164-y778k3hs 51 5 global global JJ cord-356164-y778k3hs 51 6 tobacco tobacco NN cord-356164-y778k3hs 51 7 epidemic epidemic NN cord-356164-y778k3hs 51 8 2019 2019 CD cord-356164-y778k3hs 51 9 . . . cord-356164-y778k3hs 52 1 WHO who WP cord-356164-y778k3hs 52 2 : : : cord-356164-y778k3hs 52 3 Geneva Geneva NNP cord-356164-y778k3hs 52 4 , , , cord-356164-y778k3hs 52 5 2020 2020 CD cord-356164-y778k3hs 52 6 European European NNP cord-356164-y778k3hs 52 7 Centrr Centrr NNP cord-356164-y778k3hs 52 8 for for IN cord-356164-y778k3hs 52 9 Disease Disease NNP cord-356164-y778k3hs 52 10 Prevention Prevention NNP cord-356164-y778k3hs 52 11 and and CC cord-356164-y778k3hs 52 12 Control Control NNP cord-356164-y778k3hs 52 13 . . . cord-356164-y778k3hs 53 1 Coronavirus Coronavirus NNP cord-356164-y778k3hs 53 2 disease disease NN cord-356164-y778k3hs 53 3 2019 2019 CD cord-356164-y778k3hs 53 4 ( ( -LRB- cord-356164-y778k3hs 53 5 COVID-19 COVID-19 NNP cord-356164-y778k3hs 53 6 ) ) -RRB- cord-356164-y778k3hs 53 7 pandemic pandemic NN cord-356164-y778k3hs 53 8 : : : cord-356164-y778k3hs 53 9 increased increase VBN cord-356164-y778k3hs 53 10 transmission transmission NN cord-356164-y778k3hs 53 11 in in IN cord-356164-y778k3hs 53 12 the the DT cord-356164-y778k3hs 53 13 EU EU NNP cord-356164-y778k3hs 53 14 / / SYM cord-356164-y778k3hs 53 15 EEA EEA NNP cord-356164-y778k3hs 53 16 and and CC cord-356164-y778k3hs 53 17 the the DT cord-356164-y778k3hs 53 18 UK UK NNP cord-356164-y778k3hs 53 19 -seventh -seventh NN cord-356164-y778k3hs 53 20 update update NN cord-356164-y778k3hs 53 21 . . . cord-356164-y778k3hs 54 1 ECDC ECDC NNP cord-356164-y778k3hs 54 2 : : : cord-356164-y778k3hs 55 1 Stockholm Stockholm NNP cord-356164-y778k3hs 55 2 Clinical clinical JJ cord-356164-y778k3hs 55 3 characteristics characteristic NNS cord-356164-y778k3hs 55 4 of of IN cord-356164-y778k3hs 55 5 coronavirus coronavirus NN cord-356164-y778k3hs 55 6 disease disease NN cord-356164-y778k3hs 55 7 2019 2019 CD cord-356164-y778k3hs 55 8 in in IN cord-356164-y778k3hs 55 9 China China NNP cord-356164-y778k3hs 55 10 Analysis Analysis NNP cord-356164-y778k3hs 55 11 of of IN cord-356164-y778k3hs 55 12 factors factor NNS cord-356164-y778k3hs 55 13 associated associate VBN cord-356164-y778k3hs 55 14 with with IN cord-356164-y778k3hs 55 15 disease disease NN cord-356164-y778k3hs 55 16 outcomes outcome NNS cord-356164-y778k3hs 55 17 in in IN cord-356164-y778k3hs 55 18 hospitalized hospitalize VBN cord-356164-y778k3hs 55 19 patients patient NNS cord-356164-y778k3hs 55 20 with with IN cord-356164-y778k3hs 55 21 2019 2019 CD cord-356164-y778k3hs 55 22 novel novel JJ cord-356164-y778k3hs 55 23 coronavirus coronavirus NN cord-356164-y778k3hs 55 24 disease disease NN cord-356164-y778k3hs 55 25 Eleven Eleven NNP cord-356164-y778k3hs 55 26 faces face NNS cord-356164-y778k3hs 55 27 of of IN cord-356164-y778k3hs 55 28 coronavirus coronavirus NN cord-356164-y778k3hs 55 29 disease disease NN cord-356164-y778k3hs 55 30 2019 2019 CD cord-356164-y778k3hs 55 31 Medical medical JJ cord-356164-y778k3hs 55 32 management management NN cord-356164-y778k3hs 55 33 and and CC cord-356164-y778k3hs 55 34 prevention prevention NN cord-356164-y778k3hs 55 35 instruction instruction NN cord-356164-y778k3hs 55 36 of of IN cord-356164-y778k3hs 55 37 chronic chronic JJ cord-356164-y778k3hs 55 38 obstructive obstructive JJ cord-356164-y778k3hs 55 39 pulmonary pulmonary JJ cord-356164-y778k3hs 55 40 disease disease NN cord-356164-y778k3hs 55 41 during during IN cord-356164-y778k3hs 55 42 the the DT cord-356164-y778k3hs 55 43 coronavirus coronavirus NN cord-356164-y778k3hs 55 44 disease disease NN cord-356164-y778k3hs 55 45 2019 2019 CD cord-356164-y778k3hs 55 46 epidemic epidemic NN cord-356164-y778k3hs 55 47 . . . cord-356164-y778k3hs 56 1 Zhonghua Zhonghua NNP cord-356164-y778k3hs 56 2 Jie Jie NNP cord-356164-y778k3hs 57 1 He -PRON- PRP cord-356164-y778k3hs 58 1 He -PRON- PRP cord-356164-y778k3hs 58 2 Hu Hu NNP cord-356164-y778k3hs 59 1 Xi Xi NNP cord-356164-y778k3hs 59 2 Za Za NNP cord-356164-y778k3hs 59 3 Zhi Zhi NNP cord-356164-y778k3hs 59 4 SARS SARS NNP cord-356164-y778k3hs 59 5 - - HYPH cord-356164-y778k3hs 59 6 CoV-2 CoV-2 NNP cord-356164-y778k3hs 59 7 viral viral JJ cord-356164-y778k3hs 59 8 load load NN cord-356164-y778k3hs 59 9 in in IN cord-356164-y778k3hs 59 10 upper upper JJ cord-356164-y778k3hs 59 11 respiratory respiratory JJ cord-356164-y778k3hs 59 12 specimens specimen NNS cord-356164-y778k3hs 59 13 of of IN cord-356164-y778k3hs 59 14 infected infected JJ cord-356164-y778k3hs 59 15 patients patient NNS cord-356164-y778k3hs 60 1 A a DT cord-356164-y778k3hs 60 2 pneumonia pneumonia NN cord-356164-y778k3hs 60 3 outbreak outbreak NN cord-356164-y778k3hs 60 4 associated associate VBN cord-356164-y778k3hs 60 5 with with IN cord-356164-y778k3hs 60 6 a a DT cord-356164-y778k3hs 60 7 new new JJ cord-356164-y778k3hs 60 8 coronavirus coronavirus NN cord-356164-y778k3hs 60 9 of of IN cord-356164-y778k3hs 60 10 probable probable JJ cord-356164-y778k3hs 60 11 bat bat NN cord-356164-y778k3hs 60 12 origin origin NN cord-356164-y778k3hs 60 13 Cancer cancer NN cord-356164-y778k3hs 60 14 patients patient NNS cord-356164-y778k3hs 60 15 in in IN cord-356164-y778k3hs 60 16 SARS SARS NNP cord-356164-y778k3hs 60 17 - - HYPH cord-356164-y778k3hs 60 18 CoV-2 CoV-2 NNP cord-356164-y778k3hs 60 19 infection infection NN cord-356164-y778k3hs 60 20 : : : cord-356164-y778k3hs 60 21 a a DT cord-356164-y778k3hs 60 22 nationwide nationwide JJ cord-356164-y778k3hs 60 23 analysis analysis NN cord-356164-y778k3hs 60 24 in in IN cord-356164-y778k3hs 60 25 China China NNP cord-356164-y778k3hs 60 26 Risk Risk NNP cord-356164-y778k3hs 60 27 of of IN cord-356164-y778k3hs 60 28 COVID-19 COVID-19 NNP cord-356164-y778k3hs 60 29 for for IN cord-356164-y778k3hs 60 30 cancer cancer NN cord-356164-y778k3hs 60 31 patients patient NNS cord-356164-y778k3hs 60 32 WHO who WP cord-356164-y778k3hs 60 33 . . . cord-356164-y778k3hs 61 1 Q&A Q&A NNP cord-356164-y778k3hs 61 2 on on IN cord-356164-y778k3hs 61 3 smoking smoking NN cord-356164-y778k3hs 61 4 and and CC cord-356164-y778k3hs 61 5 COVID-19 covid-19 NN cord-356164-y778k3hs 61 6 . . . cord-356164-y778k3hs 62 1 WHO who WP cord-356164-y778k3hs 62 2 : : : cord-356164-y778k3hs 63 1 Geneva Geneva NNP cord-356164-y778k3hs 63 2 , , , cord-356164-y778k3hs 63 3 2020 2020 CD cord-356164-y778k3hs 63 4 Position Position NNP cord-356164-y778k3hs 63 5 statement statement NN cord-356164-y778k3hs 63 6 of of IN cord-356164-y778k3hs 63 7 the the DT cord-356164-y778k3hs 63 8 ESC ESC NNP cord-356164-y778k3hs 63 9 Council Council NNP cord-356164-y778k3hs 63 10 on on IN cord-356164-y778k3hs 63 11 Hypertension Hypertension NNP cord-356164-y778k3hs 63 12 on on IN cord-356164-y778k3hs 63 13 ACE ace NN cord-356164-y778k3hs 63 14 - - HYPH cord-356164-y778k3hs 63 15 inhibitors inhibitor NNS cord-356164-y778k3hs 63 16 and and CC cord-356164-y778k3hs 63 17 angiotensin angiotensin NN cord-356164-y778k3hs 63 18 receptor receptor NN cord-356164-y778k3hs 63 19 blockers blocker NNS cord-356164-y778k3hs 63 20 Are be VBP cord-356164-y778k3hs 63 21 patients patient NNS cord-356164-y778k3hs 63 22 with with IN cord-356164-y778k3hs 63 23 hypertension hypertension NN cord-356164-y778k3hs 63 24 and and CC cord-356164-y778k3hs 63 25 diabetes diabetes NN cord-356164-y778k3hs 63 26 mellitus mellitus NN cord-356164-y778k3hs 63 27 at at IN cord-356164-y778k3hs 63 28 increased increase VBN cord-356164-y778k3hs 63 29 risk risk NN cord-356164-y778k3hs 63 30 for for IN cord-356164-y778k3hs 63 31 COVID-19 covid-19 JJ cord-356164-y778k3hs 63 32 infection infection NN cord-356164-y778k3hs 63 33 ? ? .