id sid tid token lemma pos cord-354900-bzv4yhqi 1 1 key key JJ cord-354900-bzv4yhqi 1 2 : : : cord-354900-bzv4yhqi 1 3 cord-354900-bzv4yhqi cord-354900-bzv4yhqi NNS cord-354900-bzv4yhqi 1 4 authors author NNS cord-354900-bzv4yhqi 1 5 : : : cord-354900-bzv4yhqi 1 6 Jawhara Jawhara NNP cord-354900-bzv4yhqi 1 7 , , , cord-354900-bzv4yhqi 1 8 Samir Samir NNP cord-354900-bzv4yhqi 1 9 title title NN cord-354900-bzv4yhqi 1 10 : : : cord-354900-bzv4yhqi 1 11 How how WRB cord-354900-bzv4yhqi 1 12 to to TO cord-354900-bzv4yhqi 1 13 boost boost VB cord-354900-bzv4yhqi 1 14 the the DT cord-354900-bzv4yhqi 1 15 immune immune JJ cord-354900-bzv4yhqi 1 16 defence defence NN cord-354900-bzv4yhqi 1 17 prior prior RB cord-354900-bzv4yhqi 1 18 to to IN cord-354900-bzv4yhqi 1 19 respiratory respiratory JJ cord-354900-bzv4yhqi 1 20 virus virus NN cord-354900-bzv4yhqi 1 21 infections infection NNS cord-354900-bzv4yhqi 1 22 with with IN cord-354900-bzv4yhqi 1 23 the the DT cord-354900-bzv4yhqi 1 24 special special JJ cord-354900-bzv4yhqi 1 25 focus focus NN cord-354900-bzv4yhqi 1 26 on on IN cord-354900-bzv4yhqi 1 27 coronavirus coronavirus NN cord-354900-bzv4yhqi 1 28 infections infection NNS cord-354900-bzv4yhqi 1 29 date date NN cord-354900-bzv4yhqi 1 30 : : : cord-354900-bzv4yhqi 1 31 2020 2020 CD cord-354900-bzv4yhqi 1 32 - - SYM cord-354900-bzv4yhqi 1 33 10 10 CD cord-354900-bzv4yhqi 1 34 - - SYM cord-354900-bzv4yhqi 1 35 12 12 CD cord-354900-bzv4yhqi 1 36 journal journal NN cord-354900-bzv4yhqi 1 37 : : : cord-354900-bzv4yhqi 2 1 Gut gut VB cord-354900-bzv4yhqi 2 2 Pathog Pathog NNP cord-354900-bzv4yhqi 2 3 DOI doi NN cord-354900-bzv4yhqi 2 4 : : : cord-354900-bzv4yhqi 3 1 10.1186 10.1186 CD cord-354900-bzv4yhqi 3 2 / / SYM cord-354900-bzv4yhqi 3 3 s13099 s13099 NN cord-354900-bzv4yhqi 3 4 - - HYPH cord-354900-bzv4yhqi 3 5 020 020 CD cord-354900-bzv4yhqi 3 6 - - HYPH cord-354900-bzv4yhqi 3 7 00385 00385 CD cord-354900-bzv4yhqi 3 8 - - SYM cord-354900-bzv4yhqi 3 9 2 2 CD cord-354900-bzv4yhqi 3 10 sha sha NN cord-354900-bzv4yhqi 3 11 : : : cord-354900-bzv4yhqi 4 1 0936728202161e27959c416bda02eddcf9738f97 0936728202161e27959c416bda02eddcf9738f97 NNP cord-354900-bzv4yhqi 4 2 doc_id doc_id CD cord-354900-bzv4yhqi 4 3 : : : cord-354900-bzv4yhqi 4 4 354900 354900 CD cord-354900-bzv4yhqi 4 5 cord_uid cord_uid NNS cord-354900-bzv4yhqi 4 6 : : : cord-354900-bzv4yhqi 5 1 bzv4yhqi bzv4yhqi VBN cord-354900-bzv4yhqi 6 1 The the DT cord-354900-bzv4yhqi 6 2 emergence emergence NN cord-354900-bzv4yhqi 6 3 of of IN cord-354900-bzv4yhqi 6 4 the the DT cord-354900-bzv4yhqi 6 5 novel novel JJ cord-354900-bzv4yhqi 6 6 coronavirus coronavirus NN cord-354900-bzv4yhqi 6 7 SARS SARS NNP cord-354900-bzv4yhqi 6 8 - - HYPH cord-354900-bzv4yhqi 6 9 CoV-2 CoV-2 NNP cord-354900-bzv4yhqi 6 10 , , , cord-354900-bzv4yhqi 6 11 which which WDT cord-354900-bzv4yhqi 6 12 causes cause VBZ cord-354900-bzv4yhqi 6 13 severe severe JJ cord-354900-bzv4yhqi 6 14 respiratory respiratory JJ cord-354900-bzv4yhqi 6 15 tract tract NN cord-354900-bzv4yhqi 6 16 infections infection NNS cord-354900-bzv4yhqi 6 17 in in IN cord-354900-bzv4yhqi 6 18 humans human NNS cord-354900-bzv4yhqi 6 19 ( ( -LRB- cord-354900-bzv4yhqi 6 20 COVID-19 COVID-19 NNP cord-354900-bzv4yhqi 6 21 ) ) -RRB- cord-354900-bzv4yhqi 6 22 , , , cord-354900-bzv4yhqi 6 23 has have VBZ cord-354900-bzv4yhqi 6 24 become become VBN cord-354900-bzv4yhqi 6 25 a a DT cord-354900-bzv4yhqi 6 26 global global JJ cord-354900-bzv4yhqi 6 27 health health NN cord-354900-bzv4yhqi 6 28 concern concern NN cord-354900-bzv4yhqi 6 29 . . . cord-354900-bzv4yhqi 7 1 One one CD cord-354900-bzv4yhqi 7 2 of of IN cord-354900-bzv4yhqi 7 3 the the DT cord-354900-bzv4yhqi 7 4 most most RBS cord-354900-bzv4yhqi 7 5 worrying worrying JJ cord-354900-bzv4yhqi 7 6 features feature NNS cord-354900-bzv4yhqi 7 7 of of IN cord-354900-bzv4yhqi 7 8 COVID-19 COVID-19 NNP cord-354900-bzv4yhqi 7 9 is be VBZ cord-354900-bzv4yhqi 7 10 a a DT cord-354900-bzv4yhqi 7 11 phenomenon phenomenon NN cord-354900-bzv4yhqi 7 12 known know VBN cord-354900-bzv4yhqi 7 13 as as IN cord-354900-bzv4yhqi 7 14 the the DT cord-354900-bzv4yhqi 7 15 “ " `` cord-354900-bzv4yhqi 7 16 cytokine cytokine NN cord-354900-bzv4yhqi 7 17 storm storm NN cord-354900-bzv4yhqi 7 18 ” " '' cord-354900-bzv4yhqi 7 19 , , , cord-354900-bzv4yhqi 7 20 which which WDT cord-354900-bzv4yhqi 7 21 is be VBZ cord-354900-bzv4yhqi 7 22 a a DT cord-354900-bzv4yhqi 7 23 rapid rapid JJ cord-354900-bzv4yhqi 7 24 overreaction overreaction NN cord-354900-bzv4yhqi 7 25 of of IN cord-354900-bzv4yhqi 7 26 the the DT cord-354900-bzv4yhqi 7 27 immune immune JJ cord-354900-bzv4yhqi 7 28 system system NN cord-354900-bzv4yhqi 7 29 . . . cord-354900-bzv4yhqi 8 1 Additionally additionally RB cord-354900-bzv4yhqi 8 2 , , , cord-354900-bzv4yhqi 8 3 coagulation coagulation NN cord-354900-bzv4yhqi 8 4 abnormalities abnormality NNS cord-354900-bzv4yhqi 8 5 , , , cord-354900-bzv4yhqi 8 6 thrombocytopenia thrombocytopenia NN cord-354900-bzv4yhqi 8 7 and and CC cord-354900-bzv4yhqi 8 8 digestive digestive JJ cord-354900-bzv4yhqi 8 9 symptoms symptom NNS cord-354900-bzv4yhqi 8 10 , , , cord-354900-bzv4yhqi 8 11 including include VBG cord-354900-bzv4yhqi 8 12 anorexia anorexia NN cord-354900-bzv4yhqi 8 13 , , , cord-354900-bzv4yhqi 8 14 vomiting vomiting NN cord-354900-bzv4yhqi 8 15 , , , cord-354900-bzv4yhqi 8 16 and and CC cord-354900-bzv4yhqi 8 17 diarrhea diarrhea NN cord-354900-bzv4yhqi 8 18 , , , cord-354900-bzv4yhqi 8 19 are be VBP cord-354900-bzv4yhqi 8 20 often often RB cord-354900-bzv4yhqi 8 21 observed observe VBN cord-354900-bzv4yhqi 8 22 in in IN cord-354900-bzv4yhqi 8 23 critically critically RB cord-354900-bzv4yhqi 8 24 ill ill JJ cord-354900-bzv4yhqi 8 25 patients patient NNS cord-354900-bzv4yhqi 8 26 with with IN cord-354900-bzv4yhqi 8 27 COVID-19 COVID-19 NNP cord-354900-bzv4yhqi 8 28 . . . cord-354900-bzv4yhqi 9 1 Baker Baker NNP cord-354900-bzv4yhqi 9 2 ’s ’s POS cord-354900-bzv4yhqi 9 3 yeast yeast NN cord-354900-bzv4yhqi 9 4 β β NN cord-354900-bzv4yhqi 9 5 - - HYPH cord-354900-bzv4yhqi 9 6 glucan glucan NNP cord-354900-bzv4yhqi 9 7 , , , cord-354900-bzv4yhqi 9 8 a a DT cord-354900-bzv4yhqi 9 9 natural natural JJ cord-354900-bzv4yhqi 9 10 immunomodulatory immunomodulatory JJ cord-354900-bzv4yhqi 9 11 component component NN cord-354900-bzv4yhqi 9 12 derived derive VBN cord-354900-bzv4yhqi 9 13 from from IN cord-354900-bzv4yhqi 9 14 Saccharomyces Saccharomyces NNP cord-354900-bzv4yhqi 9 15 cerevisiae cerevisiae NNS cord-354900-bzv4yhqi 9 16 , , , cord-354900-bzv4yhqi 9 17 primes prime VBZ cord-354900-bzv4yhqi 9 18 the the DT cord-354900-bzv4yhqi 9 19 immune immune JJ cord-354900-bzv4yhqi 9 20 system system NN cord-354900-bzv4yhqi 9 21 to to TO cord-354900-bzv4yhqi 9 22 respond respond VB cord-354900-bzv4yhqi 9 23 better better RB cord-354900-bzv4yhqi 9 24 to to IN cord-354900-bzv4yhqi 9 25 any any DT cord-354900-bzv4yhqi 9 26 microbial microbial JJ cord-354900-bzv4yhqi 9 27 infection infection NN cord-354900-bzv4yhqi 9 28 . . . cord-354900-bzv4yhqi 10 1 Our -PRON- PRP$ cord-354900-bzv4yhqi 10 2 previous previous JJ cord-354900-bzv4yhqi 10 3 studies study NNS cord-354900-bzv4yhqi 10 4 have have VBP cord-354900-bzv4yhqi 10 5 shown show VBN cord-354900-bzv4yhqi 10 6 that that IN cord-354900-bzv4yhqi 10 7 oral oral JJ cord-354900-bzv4yhqi 10 8 administration administration NN cord-354900-bzv4yhqi 10 9 of of IN cord-354900-bzv4yhqi 10 10 yeast yeast NNP cord-354900-bzv4yhqi 10 11 β β NNP cord-354900-bzv4yhqi 10 12 - - HYPH cord-354900-bzv4yhqi 10 13 glucans glucan NNS cord-354900-bzv4yhqi 10 14 decreased decrease VBD cord-354900-bzv4yhqi 10 15 the the DT cord-354900-bzv4yhqi 10 16 diarrhoea diarrhoea NN cord-354900-bzv4yhqi 10 17 , , , cord-354900-bzv4yhqi 10 18 modulated modulate VBN cord-354900-bzv4yhqi 10 19 cytokine cytokine JJ cord-354900-bzv4yhqi 10 20 expression expression NN cord-354900-bzv4yhqi 10 21 , , , cord-354900-bzv4yhqi 10 22 and and CC cord-354900-bzv4yhqi 10 23 reduced reduce VBD cord-354900-bzv4yhqi 10 24 the the DT cord-354900-bzv4yhqi 10 25 intestinal intestinal JJ cord-354900-bzv4yhqi 10 26 inflammation inflammation NN cord-354900-bzv4yhqi 10 27 . . . cord-354900-bzv4yhqi 11 1 Additionally additionally RB cord-354900-bzv4yhqi 11 2 , , , cord-354900-bzv4yhqi 11 3 we -PRON- PRP cord-354900-bzv4yhqi 11 4 showed show VBD cord-354900-bzv4yhqi 11 5 that that IN cord-354900-bzv4yhqi 11 6 β β NN cord-354900-bzv4yhqi 11 7 - - HYPH cord-354900-bzv4yhqi 11 8 glucan glucan JJ cord-354900-bzv4yhqi 11 9 fractions fraction NNS cord-354900-bzv4yhqi 11 10 decreased decrease VBD cord-354900-bzv4yhqi 11 11 coagulation coagulation NN cord-354900-bzv4yhqi 11 12 in in IN cord-354900-bzv4yhqi 11 13 plasma plasma NN cord-354900-bzv4yhqi 11 14 and and CC cord-354900-bzv4yhqi 11 15 reduced reduce VBD cord-354900-bzv4yhqi 11 16 the the DT cord-354900-bzv4yhqi 11 17 activation activation NN cord-354900-bzv4yhqi 11 18 of of IN cord-354900-bzv4yhqi 11 19 platelets platelet NNS cord-354900-bzv4yhqi 11 20 . . . cord-354900-bzv4yhqi 12 1 During during IN cord-354900-bzv4yhqi 12 2 the the DT cord-354900-bzv4yhqi 12 3 period period NN cord-354900-bzv4yhqi 12 4 of of IN cord-354900-bzv4yhqi 12 5 home home NN cord-354900-bzv4yhqi 12 6 confinement confinement NN cord-354900-bzv4yhqi 12 7 facing face VBG cord-354900-bzv4yhqi 12 8 individuals individual NNS cord-354900-bzv4yhqi 12 9 during during IN cord-354900-bzv4yhqi 12 10 the the DT cord-354900-bzv4yhqi 12 11 COVID-19 COVID-19 NNP cord-354900-bzv4yhqi 12 12 pandemic pandemic NN cord-354900-bzv4yhqi 12 13 , , , cord-354900-bzv4yhqi 12 14 our -PRON- PRP$ cord-354900-bzv4yhqi 12 15 immune immune JJ cord-354900-bzv4yhqi 12 16 defence defence NN cord-354900-bzv4yhqi 12 17 could could MD cord-354900-bzv4yhqi 12 18 be be VB cord-354900-bzv4yhqi 12 19 weakened weaken VBN cord-354900-bzv4yhqi 12 20 by by IN cord-354900-bzv4yhqi 12 21 different different JJ cord-354900-bzv4yhqi 12 22 factors factor NNS cord-354900-bzv4yhqi 12 23 , , , cord-354900-bzv4yhqi 12 24 including include VBG cord-354900-bzv4yhqi 12 25 stress stress NN cord-354900-bzv4yhqi 12 26 , , , cord-354900-bzv4yhqi 12 27 anxiety anxiety NN cord-354900-bzv4yhqi 12 28 and and CC cord-354900-bzv4yhqi 12 29 poor poor JJ cord-354900-bzv4yhqi 12 30 nutrition nutrition NN cord-354900-bzv4yhqi 12 31 , , , cord-354900-bzv4yhqi 12 32 while while IN cord-354900-bzv4yhqi 12 33 a a DT cord-354900-bzv4yhqi 12 34 healthy healthy JJ cord-354900-bzv4yhqi 12 35 diet diet NN cord-354900-bzv4yhqi 12 36 rich rich JJ cord-354900-bzv4yhqi 12 37 in in IN cord-354900-bzv4yhqi 12 38 vitamins vitamin NNS cord-354900-bzv4yhqi 12 39 C c NN cord-354900-bzv4yhqi 12 40 and and CC cord-354900-bzv4yhqi 12 41 D d NN cord-354900-bzv4yhqi 12 42 can can MD cord-354900-bzv4yhqi 12 43 reinforce reinforce VB cord-354900-bzv4yhqi 12 44 the the DT cord-354900-bzv4yhqi 12 45 immune immune JJ cord-354900-bzv4yhqi 12 46 defence defence NN cord-354900-bzv4yhqi 12 47 and and CC cord-354900-bzv4yhqi 12 48 reduce reduce VB cord-354900-bzv4yhqi 12 49 the the DT cord-354900-bzv4yhqi 12 50 risk risk NN cord-354900-bzv4yhqi 12 51 of of IN cord-354900-bzv4yhqi 12 52 microbial microbial JJ cord-354900-bzv4yhqi 12 53 infections infection NNS cord-354900-bzv4yhqi 12 54 . . . cord-354900-bzv4yhqi 13 1 Additionally additionally RB cord-354900-bzv4yhqi 13 2 , , , cord-354900-bzv4yhqi 13 3 β β NN cord-354900-bzv4yhqi 13 4 - - HYPH cord-354900-bzv4yhqi 13 5 glucan glucan NN cord-354900-bzv4yhqi 13 6 can can MD cord-354900-bzv4yhqi 13 7 be be VB cord-354900-bzv4yhqi 13 8 used use VBN cord-354900-bzv4yhqi 13 9 to to TO cord-354900-bzv4yhqi 13 10 strengthen strengthen VB cord-354900-bzv4yhqi 13 11 the the DT cord-354900-bzv4yhqi 13 12 immune immune JJ cord-354900-bzv4yhqi 13 13 defence defence NN cord-354900-bzv4yhqi 13 14 in in IN cord-354900-bzv4yhqi 13 15 healthy healthy JJ cord-354900-bzv4yhqi 13 16 individuals individual NNS cord-354900-bzv4yhqi 13 17 prior prior RB cord-354900-bzv4yhqi 13 18 to to IN cord-354900-bzv4yhqi 13 19 any any DT cord-354900-bzv4yhqi 13 20 possible possible JJ cord-354900-bzv4yhqi 13 21 viral viral JJ cord-354900-bzv4yhqi 13 22 infections infection NNS cord-354900-bzv4yhqi 13 23 . . . cord-354900-bzv4yhqi 14 1 This this DT cord-354900-bzv4yhqi 14 2 short short JJ cord-354900-bzv4yhqi 14 3 review review NN cord-354900-bzv4yhqi 14 4 focuses focus VBZ cord-354900-bzv4yhqi 14 5 on on IN cord-354900-bzv4yhqi 14 6 the the DT cord-354900-bzv4yhqi 14 7 role role NN cord-354900-bzv4yhqi 14 8 of of IN cord-354900-bzv4yhqi 14 9 baker baker NNP cord-354900-bzv4yhqi 14 10 ’s ’s POS cord-354900-bzv4yhqi 14 11 yeast yeast NN cord-354900-bzv4yhqi 14 12 β β NN cord-354900-bzv4yhqi 14 13 - - HYPH cord-354900-bzv4yhqi 14 14 glucan glucan NNP cord-354900-bzv4yhqi 14 15 , , , cord-354900-bzv4yhqi 14 16 with with IN cord-354900-bzv4yhqi 14 17 a a DT cord-354900-bzv4yhqi 14 18 healthy healthy JJ cord-354900-bzv4yhqi 14 19 diet diet NN cord-354900-bzv4yhqi 14 20 rich rich JJ cord-354900-bzv4yhqi 14 21 in in IN cord-354900-bzv4yhqi 14 22 natural natural JJ cord-354900-bzv4yhqi 14 23 vitamins vitamin NNS cord-354900-bzv4yhqi 14 24 C c NN cord-354900-bzv4yhqi 14 25 and and CC cord-354900-bzv4yhqi 14 26 D D NNP cord-354900-bzv4yhqi 14 27 , , , cord-354900-bzv4yhqi 14 28 in in IN cord-354900-bzv4yhqi 14 29 addition addition NN cord-354900-bzv4yhqi 14 30 to to IN cord-354900-bzv4yhqi 14 31 a a DT cord-354900-bzv4yhqi 14 32 healthy healthy JJ cord-354900-bzv4yhqi 14 33 gut gut NN cord-354900-bzv4yhqi 14 34 microbiota microbiota NN cord-354900-bzv4yhqi 14 35 can can MD cord-354900-bzv4yhqi 14 36 provide provide VB cord-354900-bzv4yhqi 14 37 synergistic synergistic JJ cord-354900-bzv4yhqi 14 38 immune immune JJ cord-354900-bzv4yhqi 14 39 system system NN cord-354900-bzv4yhqi 14 40 support support NN cord-354900-bzv4yhqi 14 41 , , , cord-354900-bzv4yhqi 14 42 helping help VBG cord-354900-bzv4yhqi 14 43 the the DT cord-354900-bzv4yhqi 14 44 body body NN cord-354900-bzv4yhqi 14 45 to to TO cord-354900-bzv4yhqi 14 46 naturally naturally RB cord-354900-bzv4yhqi 14 47 defend defend VB cord-354900-bzv4yhqi 14 48 prior prior RB cord-354900-bzv4yhqi 14 49 to to IN cord-354900-bzv4yhqi 14 50 respiratory respiratory JJ cord-354900-bzv4yhqi 14 51 virus virus NN cord-354900-bzv4yhqi 14 52 infections infection NNS cord-354900-bzv4yhqi 14 53 , , , cord-354900-bzv4yhqi 14 54 until until IN cord-354900-bzv4yhqi 14 55 stronger strong JJR cord-354900-bzv4yhqi 14 56 options option NNS cord-354900-bzv4yhqi 14 57 such such JJ cord-354900-bzv4yhqi 14 58 as as IN cord-354900-bzv4yhqi 14 59 vaccines vaccine NNS cord-354900-bzv4yhqi 14 60 are be VBP cord-354900-bzv4yhqi 14 61 available available JJ cord-354900-bzv4yhqi 14 62 . . . cord-354900-bzv4yhqi 15 1 to to IN cord-354900-bzv4yhqi 15 2 those those DT cord-354900-bzv4yhqi 15 3 of of IN cord-354900-bzv4yhqi 15 4 SARS SARS NNP cord-354900-bzv4yhqi 15 5 - - HYPH cord-354900-bzv4yhqi 15 6 CoV-1 CoV-1 NNP cord-354900-bzv4yhqi 15 7 [ [ -LRB- cord-354900-bzv4yhqi 15 8 8 8 CD cord-354900-bzv4yhqi 15 9 , , , cord-354900-bzv4yhqi 15 10 9 9 CD cord-354900-bzv4yhqi 15 11 ] ] -RRB- cord-354900-bzv4yhqi 15 12 . . . cord-354900-bzv4yhqi 16 1 Additionally additionally RB cord-354900-bzv4yhqi 16 2 , , , cord-354900-bzv4yhqi 16 3 other other JJ cord-354900-bzv4yhqi 16 4 studies study NNS cord-354900-bzv4yhqi 16 5 showed show VBD cord-354900-bzv4yhqi 16 6 that that IN cord-354900-bzv4yhqi 16 7 a a DT cord-354900-bzv4yhqi 16 8 high high JJ cord-354900-bzv4yhqi 16 9 coexpression coexpression NN cord-354900-bzv4yhqi 16 10 of of IN cord-354900-bzv4yhqi 16 11 ACE2 ACE2 NNP cord-354900-bzv4yhqi 16 12 and and CC cord-354900-bzv4yhqi 16 13 TMPRSS2 TMPRSS2 NNP cord-354900-bzv4yhqi 16 14 was be VBD cord-354900-bzv4yhqi 16 15 also also RB cord-354900-bzv4yhqi 16 16 detected detect VBN cord-354900-bzv4yhqi 16 17 in in IN cord-354900-bzv4yhqi 16 18 enterocytes enterocyte NNS cord-354900-bzv4yhqi 16 19 , , , cord-354900-bzv4yhqi 16 20 indicating indicate VBG cord-354900-bzv4yhqi 16 21 that that IN cord-354900-bzv4yhqi 16 22 coronaviruses coronaviruse NNS cord-354900-bzv4yhqi 16 23 may may MD cord-354900-bzv4yhqi 16 24 infect infect VB cord-354900-bzv4yhqi 16 25 the the DT cord-354900-bzv4yhqi 16 26 gastrointestinal gastrointestinal JJ cord-354900-bzv4yhqi 16 27 tract tract NN cord-354900-bzv4yhqi 16 28 and and CC cord-354900-bzv4yhqi 16 29 the the DT cord-354900-bzv4yhqi 16 30 virus virus NN cord-354900-bzv4yhqi 16 31 activity activity NN cord-354900-bzv4yhqi 16 32 may may MD cord-354900-bzv4yhqi 16 33 cause cause VB cord-354900-bzv4yhqi 16 34 enzyme enzyme NN cord-354900-bzv4yhqi 16 35 modifications modification NNS cord-354900-bzv4yhqi 16 36 , , , cord-354900-bzv4yhqi 16 37 increasing increase VBG cord-354900-bzv4yhqi 16 38 the the DT cord-354900-bzv4yhqi 16 39 susceptibility susceptibility NN cord-354900-bzv4yhqi 16 40 to to TO cord-354900-bzv4yhqi 16 41 intestinal intestinal JJ cord-354900-bzv4yhqi 16 42 inflammation inflammation NN cord-354900-bzv4yhqi 16 43 and and CC cord-354900-bzv4yhqi 16 44 diarrhea diarrhea NN cord-354900-bzv4yhqi 16 45 [ [ -LRB- cord-354900-bzv4yhqi 16 46 10 10 CD cord-354900-bzv4yhqi 16 47 , , , cord-354900-bzv4yhqi 16 48 11 11 CD cord-354900-bzv4yhqi 16 49 ] ] -RRB- cord-354900-bzv4yhqi 16 50 . . . cord-354900-bzv4yhqi 17 1 Of of IN cord-354900-bzv4yhqi 17 2 note note NN cord-354900-bzv4yhqi 17 3 , , , cord-354900-bzv4yhqi 17 4 diarrhoea diarrhoea NN cord-354900-bzv4yhqi 17 5 is be VBZ cord-354900-bzv4yhqi 17 6 a a DT cord-354900-bzv4yhqi 17 7 frequent frequent JJ cord-354900-bzv4yhqi 17 8 symptom symptom NN cord-354900-bzv4yhqi 17 9 in in IN cord-354900-bzv4yhqi 17 10 coronavirus coronavirus NN cord-354900-bzv4yhqi 17 11 infections infection NNS cord-354900-bzv4yhqi 17 12 , , , cord-354900-bzv4yhqi 17 13 it -PRON- PRP cord-354900-bzv4yhqi 17 14 was be VBD cord-354900-bzv4yhqi 17 15 detected detect VBN cord-354900-bzv4yhqi 17 16 in in IN cord-354900-bzv4yhqi 17 17 up up IN cord-354900-bzv4yhqi 17 18 to to TO cord-354900-bzv4yhqi 17 19 30 30 CD cord-354900-bzv4yhqi 17 20 % % NN cord-354900-bzv4yhqi 17 21 of of IN cord-354900-bzv4yhqi 17 22 patients patient NNS cord-354900-bzv4yhqi 17 23 with with IN cord-354900-bzv4yhqi 17 24 MERS MERS NNP cord-354900-bzv4yhqi 17 25 - - HYPH cord-354900-bzv4yhqi 17 26 CoV CoV NNP cord-354900-bzv4yhqi 17 27 and and CC cord-354900-bzv4yhqi 17 28 10.6 10.6 CD cord-354900-bzv4yhqi 17 29 % % NN cord-354900-bzv4yhqi 17 30 of of IN cord-354900-bzv4yhqi 17 31 patients patient NNS cord-354900-bzv4yhqi 17 32 with with IN cord-354900-bzv4yhqi 17 33 SARS SARS NNP cord-354900-bzv4yhqi 17 34 - - HYPH cord-354900-bzv4yhqi 17 35 CoV CoV NNP cord-354900-bzv4yhqi 17 36 [ [ -LRB- cord-354900-bzv4yhqi 17 37 12 12 CD cord-354900-bzv4yhqi 17 38 , , , cord-354900-bzv4yhqi 17 39 13 13 CD cord-354900-bzv4yhqi 17 40 ] ] -RRB- cord-354900-bzv4yhqi 17 41 . . . cord-354900-bzv4yhqi 18 1 Han Han NNP cord-354900-bzv4yhqi 18 2 et et NNP cord-354900-bzv4yhqi 18 3 al al NNP cord-354900-bzv4yhqi 18 4 . . NNP cord-354900-bzv4yhqi 18 5 showed show VBD cord-354900-bzv4yhqi 18 6 that that IN cord-354900-bzv4yhqi 18 7 COVID-19 covid-19 JJ cord-354900-bzv4yhqi 18 8 patients patient NNS cord-354900-bzv4yhqi 18 9 with with IN cord-354900-bzv4yhqi 18 10 mild mild JJ cord-354900-bzv4yhqi 18 11 disease disease NN cord-354900-bzv4yhqi 18 12 severity severity NN cord-354900-bzv4yhqi 18 13 marked mark VBN cord-354900-bzv4yhqi 18 14 by by IN cord-354900-bzv4yhqi 18 15 the the DT cord-354900-bzv4yhqi 18 16 presence presence NN cord-354900-bzv4yhqi 18 17 of of IN cord-354900-bzv4yhqi 18 18 digestive digestive JJ cord-354900-bzv4yhqi 18 19 symptoms symptom NNS cord-354900-bzv4yhqi 18 20 , , , cord-354900-bzv4yhqi 18 21 in in IN cord-354900-bzv4yhqi 18 22 particular particular JJ cord-354900-bzv4yhqi 18 23 diarrhoea diarrhoea NN cord-354900-bzv4yhqi 18 24 [ [ -LRB- cord-354900-bzv4yhqi 18 25 14 14 CD cord-354900-bzv4yhqi 18 26 ] ] -RRB- cord-354900-bzv4yhqi 18 27 . . . cord-354900-bzv4yhqi 19 1 These these DT cord-354900-bzv4yhqi 19 2 patients patient NNS cord-354900-bzv4yhqi 19 3 showed show VBD cord-354900-bzv4yhqi 19 4 a a DT cord-354900-bzv4yhqi 19 5 longer long JJR cord-354900-bzv4yhqi 19 6 delay delay NN cord-354900-bzv4yhqi 19 7 before before IN cord-354900-bzv4yhqi 19 8 viral viral JJ cord-354900-bzv4yhqi 19 9 clearance clearance NN cord-354900-bzv4yhqi 19 10 when when WRB cord-354900-bzv4yhqi 19 11 compared compare VBN cord-354900-bzv4yhqi 19 12 with with IN cord-354900-bzv4yhqi 19 13 those those DT cord-354900-bzv4yhqi 19 14 with with IN cord-354900-bzv4yhqi 19 15 only only JJ cord-354900-bzv4yhqi 19 16 respiratory respiratory JJ cord-354900-bzv4yhqi 19 17 symptoms symptom NNS cord-354900-bzv4yhqi 19 18 [ [ -LRB- cord-354900-bzv4yhqi 19 19 14 14 CD cord-354900-bzv4yhqi 19 20 ] ] -RRB- cord-354900-bzv4yhqi 19 21 . . . cord-354900-bzv4yhqi 20 1 Viral viral JJ cord-354900-bzv4yhqi 20 2 RNAs rna NNS cord-354900-bzv4yhqi 20 3 , , , cord-354900-bzv4yhqi 20 4 as as IN cord-354900-bzv4yhqi 20 5 pathogen pathogen NN cord-354900-bzv4yhqi 20 6 - - HYPH cord-354900-bzv4yhqi 20 7 associated associate VBN cord-354900-bzv4yhqi 20 8 molecular molecular JJ cord-354900-bzv4yhqi 20 9 patterns pattern NNS cord-354900-bzv4yhqi 20 10 ( ( -LRB- cord-354900-bzv4yhqi 20 11 PAMPs pamp NNS cord-354900-bzv4yhqi 20 12 ) ) -RRB- cord-354900-bzv4yhqi 20 13 , , , cord-354900-bzv4yhqi 20 14 can can MD cord-354900-bzv4yhqi 20 15 be be VB cord-354900-bzv4yhqi 20 16 recognized recognize VBN cord-354900-bzv4yhqi 20 17 by by IN cord-354900-bzv4yhqi 20 18 toll toll NN cord-354900-bzv4yhqi 20 19 - - HYPH cord-354900-bzv4yhqi 20 20 like like JJ cord-354900-bzv4yhqi 20 21 receptor receptor NN cord-354900-bzv4yhqi 20 22 ( ( -LRB- cord-354900-bzv4yhqi 20 23 TLR)3 tlr)3 XX cord-354900-bzv4yhqi 20 24 , , , cord-354900-bzv4yhqi 20 25 TLR7 TLR7 NNP cord-354900-bzv4yhqi 20 26 , , , cord-354900-bzv4yhqi 20 27 TLR8 TLR8 NNP cord-354900-bzv4yhqi 20 28 and and CC cord-354900-bzv4yhqi 20 29 TLR9 TLR9 NNP cord-354900-bzv4yhqi 20 30 , , , cord-354900-bzv4yhqi 20 31 cytosolic cytosolic JJ cord-354900-bzv4yhqi 20 32 receptor receptor NN cord-354900-bzv4yhqi 20 33 melanoma melanoma NN cord-354900-bzv4yhqi 20 34 differentiation differentiation NN cord-354900-bzv4yhqi 20 35 - - HYPH cord-354900-bzv4yhqi 20 36 associated associate VBN cord-354900-bzv4yhqi 20 37 gene gene NN cord-354900-bzv4yhqi 20 38 5 5 CD cord-354900-bzv4yhqi 20 39 , , , cord-354900-bzv4yhqi 20 40 nucleotidyl nucleotidyl NN cord-354900-bzv4yhqi 20 41 - - HYPH cord-354900-bzv4yhqi 20 42 transferase transferase NN cord-354900-bzv4yhqi 20 43 cyclic cyclic JJ cord-354900-bzv4yhqi 20 44 GMP GMP NNP cord-354900-bzv4yhqi 20 45 - - HYPH cord-354900-bzv4yhqi 20 46 AMP AMP NNP cord-354900-bzv4yhqi 20 47 synthase synthase NN cord-354900-bzv4yhqi 20 48 , , , cord-354900-bzv4yhqi 20 49 and and CC cord-354900-bzv4yhqi 20 50 retinoic retinoic JJ cord-354900-bzv4yhqi 20 51 - - HYPH cord-354900-bzv4yhqi 20 52 acid acid NN cord-354900-bzv4yhqi 20 53 inducible inducible JJ cord-354900-bzv4yhqi 20 54 gene gene NN cord-354900-bzv4yhqi 21 1 I -PRON- PRP cord-354900-bzv4yhqi 21 2 [ [ -LRB- cord-354900-bzv4yhqi 21 3 15 15 CD cord-354900-bzv4yhqi 21 4 ] ] -RRB- cord-354900-bzv4yhqi 21 5 [ [ -LRB- cord-354900-bzv4yhqi 21 6 16 16 CD cord-354900-bzv4yhqi 21 7 ] ] -RRB- cord-354900-bzv4yhqi 21 8 [ [ -LRB- cord-354900-bzv4yhqi 21 9 17 17 CD cord-354900-bzv4yhqi 21 10 ] ] -RRB- cord-354900-bzv4yhqi 21 11 [ [ -LRB- cord-354900-bzv4yhqi 21 12 18 18 CD cord-354900-bzv4yhqi 21 13 ] ] -RRB- cord-354900-bzv4yhqi 21 14 . . . cord-354900-bzv4yhqi 22 1 Sensing sensing NN cord-354900-bzv4yhqi 22 2 of of IN cord-354900-bzv4yhqi 22 3 viral viral JJ cord-354900-bzv4yhqi 22 4 RNA RNA NNP cord-354900-bzv4yhqi 22 5 by by IN cord-354900-bzv4yhqi 22 6 host host NN cord-354900-bzv4yhqi 22 7 receptors receptor NNS cord-354900-bzv4yhqi 22 8 activates activate VBZ cord-354900-bzv4yhqi 22 9 downstream downstream JJ cord-354900-bzv4yhqi 22 10 signalling signal VBG cord-354900-bzv4yhqi 22 11 pathways pathway NNS cord-354900-bzv4yhqi 22 12 that that WDT cord-354900-bzv4yhqi 22 13 lead lead VBP cord-354900-bzv4yhqi 22 14 to to IN cord-354900-bzv4yhqi 22 15 the the DT cord-354900-bzv4yhqi 22 16 induction induction NN cord-354900-bzv4yhqi 22 17 of of IN cord-354900-bzv4yhqi 22 18 immune immune JJ cord-354900-bzv4yhqi 22 19 responses response NNS cord-354900-bzv4yhqi 22 20 by by IN cord-354900-bzv4yhqi 22 21 producing produce VBG cord-354900-bzv4yhqi 22 22 inflammatory inflammatory JJ cord-354900-bzv4yhqi 22 23 cytokines cytokine NNS cord-354900-bzv4yhqi 22 24 including include VBG cord-354900-bzv4yhqi 22 25 type type NN cord-354900-bzv4yhqi 23 1 I -PRON- PRP cord-354900-bzv4yhqi 23 2 interferon interferon RB cord-354900-bzv4yhqi 23 3 ( ( -LRB- cord-354900-bzv4yhqi 23 4 IFN IFN NNP cord-354900-bzv4yhqi 23 5 ) ) -RRB- cord-354900-bzv4yhqi 23 6 and and CC cord-354900-bzv4yhqi 23 7 other other JJ cord-354900-bzv4yhqi 23 8 mediators mediator NNS cord-354900-bzv4yhqi 23 9 [ [ -LRB- cord-354900-bzv4yhqi 23 10 19 19 CD cord-354900-bzv4yhqi 23 11 ] ] -RRB- cord-354900-bzv4yhqi 23 12 . . . cord-354900-bzv4yhqi 24 1 Plasma plasma NN cord-354900-bzv4yhqi 24 2 cytokines cytokine NNS cord-354900-bzv4yhqi 24 3 and and CC cord-354900-bzv4yhqi 24 4 chemokines chemokine NNS cord-354900-bzv4yhqi 24 5 have have VBP cord-354900-bzv4yhqi 24 6 been be VBN cord-354900-bzv4yhqi 24 7 observed observe VBN cord-354900-bzv4yhqi 24 8 in in IN cord-354900-bzv4yhqi 24 9 COVID-19 COVID-19 NNP cord-354900-bzv4yhqi 24 10 patients patient NNS cord-354900-bzv4yhqi 24 11 infected infect VBN cord-354900-bzv4yhqi 24 12 with with IN cord-354900-bzv4yhqi 24 13 SARS SARS NNP cord-354900-bzv4yhqi 24 14 - - HYPH cord-354900-bzv4yhqi 24 15 CoV-2 CoV-2 NNP cord-354900-bzv4yhqi 24 16 [ [ -LRB- cord-354900-bzv4yhqi 24 17 20 20 CD cord-354900-bzv4yhqi 24 18 , , , cord-354900-bzv4yhqi 24 19 21 21 CD cord-354900-bzv4yhqi 24 20 ] ] -RRB- cord-354900-bzv4yhqi 24 21 . . . cord-354900-bzv4yhqi 25 1 Of of IN cord-354900-bzv4yhqi 25 2 note note NN cord-354900-bzv4yhqi 25 3 , , , cord-354900-bzv4yhqi 25 4 the the DT cord-354900-bzv4yhqi 25 5 SARS SARS NNP cord-354900-bzv4yhqi 25 6 - - HYPH cord-354900-bzv4yhqi 25 7 CoV-2 CoV-2 NNP cord-354900-bzv4yhqi 25 8 particles particle NNS cord-354900-bzv4yhqi 25 9 first first RB cord-354900-bzv4yhqi 25 10 invade invade VBP cord-354900-bzv4yhqi 25 11 the the DT cord-354900-bzv4yhqi 25 12 respiratory respiratory JJ cord-354900-bzv4yhqi 25 13 mucosa mucosa NN cord-354900-bzv4yhqi 25 14 and and CC cord-354900-bzv4yhqi 25 15 infect infect VBP cord-354900-bzv4yhqi 25 16 other other JJ cord-354900-bzv4yhqi 25 17 cell cell NN cord-354900-bzv4yhqi 25 18 types type NNS cord-354900-bzv4yhqi 25 19 , , , cord-354900-bzv4yhqi 25 20 causing cause VBG cord-354900-bzv4yhqi 25 21 a a DT cord-354900-bzv4yhqi 25 22 series series NN cord-354900-bzv4yhqi 25 23 of of IN cord-354900-bzv4yhqi 25 24 immune immune JJ cord-354900-bzv4yhqi 25 25 responses response NNS cord-354900-bzv4yhqi 25 26 and and CC cord-354900-bzv4yhqi 25 27 the the DT cord-354900-bzv4yhqi 25 28 overproduction overproduction NN cord-354900-bzv4yhqi 25 29 of of IN cord-354900-bzv4yhqi 25 30 cytokines cytokine NNS cord-354900-bzv4yhqi 25 31 ' ' POS cord-354900-bzv4yhqi 25 32 cytokine cytokine NN cord-354900-bzv4yhqi 25 33 storm storm NN cord-354900-bzv4yhqi 25 34 ' ' '' cord-354900-bzv4yhqi 25 35 , , , cord-354900-bzv4yhqi 25 36 which which WDT cord-354900-bzv4yhqi 25 37 may may MD cord-354900-bzv4yhqi 25 38 be be VB cord-354900-bzv4yhqi 25 39 related relate VBN cord-354900-bzv4yhqi 25 40 to to IN cord-354900-bzv4yhqi 25 41 the the DT cord-354900-bzv4yhqi 25 42 critical critical JJ cord-354900-bzv4yhqi 25 43 condition condition NN cord-354900-bzv4yhqi 25 44 of of IN cord-354900-bzv4yhqi 25 45 COVID-19 covid-19 JJ cord-354900-bzv4yhqi 25 46 patients patient NNS cord-354900-bzv4yhqi 25 47 [ [ -LRB- cord-354900-bzv4yhqi 25 48 21 21 CD cord-354900-bzv4yhqi 25 49 ] ] -RRB- cord-354900-bzv4yhqi 25 50 . . . cord-354900-bzv4yhqi 26 1 Priming prime VBG cord-354900-bzv4yhqi 26 2 the the DT cord-354900-bzv4yhqi 26 3 immune immune JJ cord-354900-bzv4yhqi 26 4 system system NN cord-354900-bzv4yhqi 26 5 with with IN cord-354900-bzv4yhqi 26 6 immunomodulatory immunomodulatory JJ cord-354900-bzv4yhqi 26 7 components component NNS cord-354900-bzv4yhqi 26 8 such such JJ cord-354900-bzv4yhqi 26 9 as as IN cord-354900-bzv4yhqi 26 10 β β NN cord-354900-bzv4yhqi 26 11 - - HYPH cord-354900-bzv4yhqi 26 12 glucans glucan NNS cord-354900-bzv4yhqi 26 13 can can MD cord-354900-bzv4yhqi 26 14 help help VB cord-354900-bzv4yhqi 26 15 to to TO cord-354900-bzv4yhqi 26 16 prevent prevent VB cord-354900-bzv4yhqi 26 17 the the DT cord-354900-bzv4yhqi 26 18 production production NN cord-354900-bzv4yhqi 26 19 of of IN cord-354900-bzv4yhqi 26 20 a a DT cord-354900-bzv4yhqi 26 21 cytokine cytokine NN cord-354900-bzv4yhqi 26 22 storm storm NN cord-354900-bzv4yhqi 26 23 in in IN cord-354900-bzv4yhqi 26 24 the the DT cord-354900-bzv4yhqi 26 25 body body NN cord-354900-bzv4yhqi 26 26 . . . cord-354900-bzv4yhqi 27 1 β β NN cord-354900-bzv4yhqi 27 2 - - HYPH cord-354900-bzv4yhqi 27 3 glucans glucan NNS cord-354900-bzv4yhqi 27 4 are be VBP cord-354900-bzv4yhqi 27 5 major major JJ cord-354900-bzv4yhqi 27 6 polymers polymer NNS cord-354900-bzv4yhqi 27 7 of of IN cord-354900-bzv4yhqi 27 8 the the DT cord-354900-bzv4yhqi 27 9 Saccharomyces Saccharomyces NNP cord-354900-bzv4yhqi 27 10 cerevisiae cerevisiae VBZ cord-354900-bzv4yhqi 27 11 cell cell NN cord-354900-bzv4yhqi 27 12 wall wall NN cord-354900-bzv4yhqi 27 13 structure structure NN cord-354900-bzv4yhqi 27 14 [ [ -LRB- cord-354900-bzv4yhqi 27 15 22 22 CD cord-354900-bzv4yhqi 27 16 ] ] -RRB- cord-354900-bzv4yhqi 27 17 . . . cord-354900-bzv4yhqi 28 1 They -PRON- PRP cord-354900-bzv4yhqi 28 2 play play VBP cord-354900-bzv4yhqi 28 3 an an DT cord-354900-bzv4yhqi 28 4 important important JJ cord-354900-bzv4yhqi 28 5 role role NN cord-354900-bzv4yhqi 28 6 in in IN cord-354900-bzv4yhqi 28 7 the the DT cord-354900-bzv4yhqi 28 8 structure structure NN cord-354900-bzv4yhqi 28 9 and and CC cord-354900-bzv4yhqi 28 10 function function NN cord-354900-bzv4yhqi 28 11 of of IN cord-354900-bzv4yhqi 28 12 the the DT cord-354900-bzv4yhqi 28 13 yeast yeast NN cord-354900-bzv4yhqi 28 14 cell cell NN cord-354900-bzv4yhqi 28 15 wall wall NN cord-354900-bzv4yhqi 28 16 [ [ -LRB- cord-354900-bzv4yhqi 28 17 22 22 CD cord-354900-bzv4yhqi 28 18 ] ] -RRB- cord-354900-bzv4yhqi 28 19 . . . cord-354900-bzv4yhqi 29 1 The the DT cord-354900-bzv4yhqi 29 2 cell cell NN cord-354900-bzv4yhqi 29 3 wall wall NN cord-354900-bzv4yhqi 29 4 of of IN cord-354900-bzv4yhqi 29 5 S. S. NNP cord-354900-bzv4yhqi 29 6 cerevisiae cerevisiae NN cord-354900-bzv4yhqi 29 7 contains contain VBZ cord-354900-bzv4yhqi 29 8 two two CD cord-354900-bzv4yhqi 29 9 types type NNS cord-354900-bzv4yhqi 29 10 of of IN cord-354900-bzv4yhqi 29 11 β β NN cord-354900-bzv4yhqi 29 12 - - HYPH cord-354900-bzv4yhqi 29 13 glucans glucan NNS cord-354900-bzv4yhqi 29 14 . . . cord-354900-bzv4yhqi 30 1 Branched branched JJ cord-354900-bzv4yhqi 30 2 β-(1 β-(1 NNP cord-354900-bzv4yhqi 30 3 , , , cord-354900-bzv4yhqi 30 4 3)-glucan 3)-glucan CD cord-354900-bzv4yhqi 30 5 accounts account VBZ cord-354900-bzv4yhqi 30 6 for for IN cord-354900-bzv4yhqi 30 7 ∼ ∼ NNP cord-354900-bzv4yhqi 30 8 50 50 CD cord-354900-bzv4yhqi 30 9 - - SYM cord-354900-bzv4yhqi 30 10 55 55 CD cord-354900-bzv4yhqi 30 11 % % NN cord-354900-bzv4yhqi 30 12 , , , cord-354900-bzv4yhqi 30 13 whereas whereas IN cord-354900-bzv4yhqi 30 14 β-(1 β-(1 NNP cord-354900-bzv4yhqi 30 15 , , , cord-354900-bzv4yhqi 30 16 6)-glucan 6)-glucan CD cord-354900-bzv4yhqi 30 17 represents represent VBZ cord-354900-bzv4yhqi 30 18 10 10 CD cord-354900-bzv4yhqi 30 19 - - SYM cord-354900-bzv4yhqi 30 20 15 15 CD cord-354900-bzv4yhqi 30 21 % % NN cord-354900-bzv4yhqi 30 22 of of IN cord-354900-bzv4yhqi 30 23 total total JJ cord-354900-bzv4yhqi 30 24 yeast yeast NN cord-354900-bzv4yhqi 30 25 cell cell NN cord-354900-bzv4yhqi 30 26 wall wall NN cord-354900-bzv4yhqi 30 27 polysaccharides polysaccharide NNS cord-354900-bzv4yhqi 30 28 [ [ -LRB- cord-354900-bzv4yhqi 30 29 22 22 CD cord-354900-bzv4yhqi 30 30 ] ] -RRB- cord-354900-bzv4yhqi 30 31 . . . cord-354900-bzv4yhqi 31 1 Extraction extraction NN cord-354900-bzv4yhqi 31 2 of of IN cord-354900-bzv4yhqi 31 3 β β NN cord-354900-bzv4yhqi 31 4 - - HYPH cord-354900-bzv4yhqi 31 5 glucans glucan NNS cord-354900-bzv4yhqi 31 6 from from IN cord-354900-bzv4yhqi 31 7 S. S. NNP cord-354900-bzv4yhqi 31 8 cerevisiae cerevisiae NNS cord-354900-bzv4yhqi 31 9 generally generally RB cord-354900-bzv4yhqi 31 10 consists consist VBZ cord-354900-bzv4yhqi 31 11 of of IN cord-354900-bzv4yhqi 31 12 two two CD cord-354900-bzv4yhqi 31 13 major major JJ cord-354900-bzv4yhqi 31 14 steps step NNS cord-354900-bzv4yhqi 31 15 including include VBG cord-354900-bzv4yhqi 31 16 yeast yeast NN cord-354900-bzv4yhqi 31 17 cell cell NN cord-354900-bzv4yhqi 31 18 lysis lysis NN cord-354900-bzv4yhqi 31 19 ( ( -LRB- cord-354900-bzv4yhqi 31 20 separation separation NN cord-354900-bzv4yhqi 31 21 of of IN cord-354900-bzv4yhqi 31 22 the the DT cord-354900-bzv4yhqi 31 23 cell cell NN cord-354900-bzv4yhqi 31 24 wall wall NN cord-354900-bzv4yhqi 31 25 from from IN cord-354900-bzv4yhqi 31 26 the the DT cord-354900-bzv4yhqi 31 27 cytoplasm cytoplasm NN cord-354900-bzv4yhqi 31 28 and and CC cord-354900-bzv4yhqi 31 29 nucleic nucleic JJ cord-354900-bzv4yhqi 31 30 acids acid NNS cord-354900-bzv4yhqi 31 31 ) ) -RRB- cord-354900-bzv4yhqi 31 32 and and CC cord-354900-bzv4yhqi 31 33 then then RB cord-354900-bzv4yhqi 31 34 alkaline alkaline JJ cord-354900-bzv4yhqi 31 35 hydrolysis hydrolysis NN cord-354900-bzv4yhqi 31 36 with with IN cord-354900-bzv4yhqi 31 37 spray spray NN cord-354900-bzv4yhqi 31 38 - - HYPH cord-354900-bzv4yhqi 31 39 drying drying NN cord-354900-bzv4yhqi 31 40 ( ( -LRB- cord-354900-bzv4yhqi 31 41 extraction extraction NN cord-354900-bzv4yhqi 31 42 from from IN cord-354900-bzv4yhqi 31 43 insoluble insoluble JJ cord-354900-bzv4yhqi 31 44 cell cell NN cord-354900-bzv4yhqi 31 45 wall wall NN cord-354900-bzv4yhqi 31 46 ) ) -RRB- cord-354900-bzv4yhqi 31 47 [ [ -LRB- cord-354900-bzv4yhqi 31 48 23 23 CD cord-354900-bzv4yhqi 31 49 ] ] -RRB- cord-354900-bzv4yhqi 31 50 . . . cord-354900-bzv4yhqi 32 1 β β NN cord-354900-bzv4yhqi 32 2 - - HYPH cord-354900-bzv4yhqi 32 3 glucans glucan NNS cord-354900-bzv4yhqi 32 4 derived derive VBN cord-354900-bzv4yhqi 32 5 from from IN cord-354900-bzv4yhqi 32 6 S. S. NNP cord-354900-bzv4yhqi 32 7 cerevisiae cerevisiae NNS cord-354900-bzv4yhqi 32 8 can can MD cord-354900-bzv4yhqi 32 9 initiate initiate VB cord-354900-bzv4yhqi 32 10 the the DT cord-354900-bzv4yhqi 32 11 innate innate JJ cord-354900-bzv4yhqi 32 12 immune immune JJ cord-354900-bzv4yhqi 32 13 response response NN cord-354900-bzv4yhqi 32 14 and and CC cord-354900-bzv4yhqi 32 15 then then RB cord-354900-bzv4yhqi 32 16 trigger trigger VB cord-354900-bzv4yhqi 32 17 an an DT cord-354900-bzv4yhqi 32 18 effective effective JJ cord-354900-bzv4yhqi 32 19 immune immune JJ cord-354900-bzv4yhqi 32 20 response response NN cord-354900-bzv4yhqi 32 21 including include VBG cord-354900-bzv4yhqi 32 22 phagocytosis phagocytosis NN cord-354900-bzv4yhqi 32 23 and and CC cord-354900-bzv4yhqi 32 24 cytokine cytokine NN cord-354900-bzv4yhqi 32 25 production production NN cord-354900-bzv4yhqi 32 26 that that WDT cord-354900-bzv4yhqi 32 27 leads lead VBZ cord-354900-bzv4yhqi 32 28 to to IN cord-354900-bzv4yhqi 32 29 fungal fungal VB cord-354900-bzv4yhqi 32 30 elimination elimination NN cord-354900-bzv4yhqi 32 31 [ [ -LRB- cord-354900-bzv4yhqi 32 32 24 24 CD cord-354900-bzv4yhqi 32 33 , , , cord-354900-bzv4yhqi 32 34 25 25 CD cord-354900-bzv4yhqi 32 35 ] ] -RRB- cord-354900-bzv4yhqi 32 36 . . . cord-354900-bzv4yhqi 33 1 Different different JJ cord-354900-bzv4yhqi 33 2 studies study NNS cord-354900-bzv4yhqi 33 3 showed show VBD cord-354900-bzv4yhqi 33 4 that that IN cord-354900-bzv4yhqi 33 5 β β NN cord-354900-bzv4yhqi 33 6 - - HYPH cord-354900-bzv4yhqi 33 7 glucans glucan NNS cord-354900-bzv4yhqi 33 8 can can MD cord-354900-bzv4yhqi 33 9 act act VB cord-354900-bzv4yhqi 33 10 as as IN cord-354900-bzv4yhqi 33 11 a a DT cord-354900-bzv4yhqi 33 12 training training NN cord-354900-bzv4yhqi 33 13 agent agent NN cord-354900-bzv4yhqi 33 14 which which WDT cord-354900-bzv4yhqi 33 15 results result VBZ cord-354900-bzv4yhqi 33 16 in in IN cord-354900-bzv4yhqi 33 17 amplified amplify VBN cord-354900-bzv4yhqi 33 18 immune immune JJ cord-354900-bzv4yhqi 33 19 responses response NNS cord-354900-bzv4yhqi 33 20 when when WRB cord-354900-bzv4yhqi 33 21 these these DT cord-354900-bzv4yhqi 33 22 trained train VBN cord-354900-bzv4yhqi 33 23 immune immune JJ cord-354900-bzv4yhqi 33 24 cells cell NNS cord-354900-bzv4yhqi 33 25 are be VBP cord-354900-bzv4yhqi 33 26 exposed expose VBN cord-354900-bzv4yhqi 33 27 to to IN cord-354900-bzv4yhqi 33 28 a a DT cord-354900-bzv4yhqi 33 29 secondary secondary JJ cord-354900-bzv4yhqi 33 30 stimulus stimulus NN cord-354900-bzv4yhqi 33 31 [ [ -LRB- cord-354900-bzv4yhqi 33 32 26 26 CD cord-354900-bzv4yhqi 33 33 , , , cord-354900-bzv4yhqi 33 34 27 27 CD cord-354900-bzv4yhqi 33 35 ] ] -RRB- cord-354900-bzv4yhqi 33 36 . . . cord-354900-bzv4yhqi 34 1 Netea Netea NNP cord-354900-bzv4yhqi 34 2 et et NNP cord-354900-bzv4yhqi 34 3 al al NNP cord-354900-bzv4yhqi 34 4 . . NNP cord-354900-bzv4yhqi 34 5 reported report VBD cord-354900-bzv4yhqi 34 6 that that IN cord-354900-bzv4yhqi 34 7 training training NN cord-354900-bzv4yhqi 34 8 of of IN cord-354900-bzv4yhqi 34 9 human human JJ cord-354900-bzv4yhqi 34 10 monocytes monocyte NNS cord-354900-bzv4yhqi 34 11 with with IN cord-354900-bzv4yhqi 34 12 β β NN cord-354900-bzv4yhqi 34 13 - - HYPH cord-354900-bzv4yhqi 34 14 glucan glucan NN cord-354900-bzv4yhqi 34 15 promotes promote VBZ cord-354900-bzv4yhqi 34 16 to to IN cord-354900-bzv4yhqi 34 17 enhanced enhance VBN cord-354900-bzv4yhqi 34 18 capacity capacity NN cord-354900-bzv4yhqi 34 19 of of IN cord-354900-bzv4yhqi 34 20 the the DT cord-354900-bzv4yhqi 34 21 immune immune JJ cord-354900-bzv4yhqi 34 22 response response NN cord-354900-bzv4yhqi 34 23 to to TO cord-354900-bzv4yhqi 34 24 eliminate eliminate VB cord-354900-bzv4yhqi 34 25 not not RB cord-354900-bzv4yhqi 34 26 only only RB cord-354900-bzv4yhqi 34 27 fungi fungus NNS cord-354900-bzv4yhqi 34 28 , , , cord-354900-bzv4yhqi 34 29 but but CC cord-354900-bzv4yhqi 34 30 also also RB cord-354900-bzv4yhqi 34 31 bacteria bacteria NNS cord-354900-bzv4yhqi 34 32 , , , cord-354900-bzv4yhqi 34 33 viruses virus NNS cord-354900-bzv4yhqi 34 34 and and CC cord-354900-bzv4yhqi 34 35 even even RB cord-354900-bzv4yhqi 34 36 parasites parasite NNS cord-354900-bzv4yhqi 34 37 [ [ -LRB- cord-354900-bzv4yhqi 34 38 27 27 CD cord-354900-bzv4yhqi 34 39 ] ] -RRB- cord-354900-bzv4yhqi 34 40 . . . cord-354900-bzv4yhqi 35 1 The the DT cord-354900-bzv4yhqi 35 2 phenomenon phenomenon NN cord-354900-bzv4yhqi 35 3 of of IN cord-354900-bzv4yhqi 35 4 trained train VBN cord-354900-bzv4yhqi 35 5 innate innate JJ cord-354900-bzv4yhqi 35 6 immunity immunity NN cord-354900-bzv4yhqi 35 7 following follow VBG cord-354900-bzv4yhqi 35 8 exposure exposure NN cord-354900-bzv4yhqi 35 9 to to IN cord-354900-bzv4yhqi 35 10 β β NN cord-354900-bzv4yhqi 35 11 - - HYPH cord-354900-bzv4yhqi 35 12 glucan glucan NN cord-354900-bzv4yhqi 35 13 is be VBZ cord-354900-bzv4yhqi 35 14 accompanied accompany VBN cord-354900-bzv4yhqi 35 15 by by IN cord-354900-bzv4yhqi 35 16 epigenetic epigenetic JJ cord-354900-bzv4yhqi 35 17 mechanisms mechanism NNS cord-354900-bzv4yhqi 35 18 involving involve VBG cord-354900-bzv4yhqi 35 19 histone histone NN cord-354900-bzv4yhqi 35 20 modifications modification NNS cord-354900-bzv4yhqi 35 21 , , , cord-354900-bzv4yhqi 35 22 reconfiguration reconfiguration NN cord-354900-bzv4yhqi 35 23 of of IN cord-354900-bzv4yhqi 35 24 chromatin chromatin NN cord-354900-bzv4yhqi 35 25 and and CC cord-354900-bzv4yhqi 35 26 changes change NNS cord-354900-bzv4yhqi 35 27 in in IN cord-354900-bzv4yhqi 35 28 metabolic metabolic JJ cord-354900-bzv4yhqi 35 29 function function NN cord-354900-bzv4yhqi 35 30 that that WDT cord-354900-bzv4yhqi 35 31 include include VBP cord-354900-bzv4yhqi 35 32 increased increase VBN cord-354900-bzv4yhqi 35 33 aerobic aerobic JJ cord-354900-bzv4yhqi 35 34 glycolysis glycolysis NN cord-354900-bzv4yhqi 35 35 [ [ -LRB- cord-354900-bzv4yhqi 35 36 28 28 CD cord-354900-bzv4yhqi 35 37 , , , cord-354900-bzv4yhqi 35 38 29 29 CD cord-354900-bzv4yhqi 35 39 ] ] -RRB- cord-354900-bzv4yhqi 35 40 . . . cord-354900-bzv4yhqi 36 1 These these DT cord-354900-bzv4yhqi 36 2 epigenetic epigenetic JJ cord-354900-bzv4yhqi 36 3 modifications modification NNS cord-354900-bzv4yhqi 36 4 allow allow VBP cord-354900-bzv4yhqi 36 5 the the DT cord-354900-bzv4yhqi 36 6 innate innate JJ cord-354900-bzv4yhqi 36 7 immune immune JJ cord-354900-bzv4yhqi 36 8 cells cell NNS cord-354900-bzv4yhqi 36 9 to to TO cord-354900-bzv4yhqi 36 10 acquire acquire VB cord-354900-bzv4yhqi 36 11 a a DT cord-354900-bzv4yhqi 36 12 memory memory NN cord-354900-bzv4yhqi 36 13 phenotype phenotype NN cord-354900-bzv4yhqi 36 14 of of IN cord-354900-bzv4yhqi 36 15 enhanced enhanced JJ cord-354900-bzv4yhqi 36 16 immune immune JJ cord-354900-bzv4yhqi 36 17 responses response NNS cord-354900-bzv4yhqi 36 18 when when WRB cord-354900-bzv4yhqi 36 19 exposed expose VBN cord-354900-bzv4yhqi 36 20 to to IN cord-354900-bzv4yhqi 36 21 a a DT cord-354900-bzv4yhqi 36 22 secondary secondary JJ cord-354900-bzv4yhqi 36 23 stimulus stimulus NN cord-354900-bzv4yhqi 36 24 [ [ -LRB- cord-354900-bzv4yhqi 36 25 28 28 CD cord-354900-bzv4yhqi 36 26 ] ] -RRB- cord-354900-bzv4yhqi 36 27 . . . cord-354900-bzv4yhqi 37 1 It -PRON- PRP cord-354900-bzv4yhqi 37 2 has have VBZ cord-354900-bzv4yhqi 37 3 been be VBN cord-354900-bzv4yhqi 37 4 reported report VBN cord-354900-bzv4yhqi 37 5 that that IN cord-354900-bzv4yhqi 37 6 soluble soluble JJ cord-354900-bzv4yhqi 37 7 β β NN cord-354900-bzv4yhqi 37 8 - - HYPH cord-354900-bzv4yhqi 37 9 glucans glucan NNS cord-354900-bzv4yhqi 37 10 are be VBP cord-354900-bzv4yhqi 37 11 recognized recognize VBN cord-354900-bzv4yhqi 37 12 by by IN cord-354900-bzv4yhqi 37 13 dendritic dendritic JJ cord-354900-bzv4yhqi 37 14 cells cell NNS cord-354900-bzv4yhqi 37 15 ( ( -LRB- cord-354900-bzv4yhqi 37 16 DCs DCs NNP cord-354900-bzv4yhqi 37 17 ) ) -RRB- cord-354900-bzv4yhqi 37 18 and and CC cord-354900-bzv4yhqi 37 19 macrophages macrophage NNS cord-354900-bzv4yhqi 37 20 present present JJ cord-354900-bzv4yhqi 37 21 in in IN cord-354900-bzv4yhqi 37 22 Peyer Peyer NNP cord-354900-bzv4yhqi 37 23 's 's POS cord-354900-bzv4yhqi 37 24 patches patch NNS cord-354900-bzv4yhqi 37 25 and and CC cord-354900-bzv4yhqi 37 26 contributed contribute VBD cord-354900-bzv4yhqi 37 27 to to IN cord-354900-bzv4yhqi 37 28 maturation maturation NN cord-354900-bzv4yhqi 37 29 of of IN cord-354900-bzv4yhqi 37 30 DC DC NNP cord-354900-bzv4yhqi 37 31 through through IN cord-354900-bzv4yhqi 37 32 the the DT cord-354900-bzv4yhqi 37 33 dectin-1 dectin-1 NNP cord-354900-bzv4yhqi 37 34 pathway pathway NN cord-354900-bzv4yhqi 37 35 [ [ -LRB- cord-354900-bzv4yhqi 37 36 30 30 CD cord-354900-bzv4yhqi 37 37 ] ] -RRB- cord-354900-bzv4yhqi 37 38 . . . cord-354900-bzv4yhqi 38 1 In in IN cord-354900-bzv4yhqi 38 2 addition addition NN cord-354900-bzv4yhqi 38 3 , , , cord-354900-bzv4yhqi 38 4 we -PRON- PRP cord-354900-bzv4yhqi 38 5 showed show VBD cord-354900-bzv4yhqi 38 6 that that IN cord-354900-bzv4yhqi 38 7 administration administration NN cord-354900-bzv4yhqi 38 8 of of IN cord-354900-bzv4yhqi 38 9 β β NNP cord-354900-bzv4yhqi 38 10 - - HYPH cord-354900-bzv4yhqi 38 11 glucans glucan NNS cord-354900-bzv4yhqi 38 12 derived derive VBN cord-354900-bzv4yhqi 38 13 from from IN cord-354900-bzv4yhqi 38 14 yeasts yeast NNS cord-354900-bzv4yhqi 38 15 to to IN cord-354900-bzv4yhqi 38 16 mice mouse NNS cord-354900-bzv4yhqi 38 17 diminished diminish VBD cord-354900-bzv4yhqi 38 18 the the DT cord-354900-bzv4yhqi 38 19 overgrowth overgrowth NN cord-354900-bzv4yhqi 38 20 of of IN cord-354900-bzv4yhqi 38 21 Enterococcus Enterococcus NNP cord-354900-bzv4yhqi 38 22 faecalis faecalis NNP cord-354900-bzv4yhqi 38 23 and and CC cord-354900-bzv4yhqi 38 24 Escherichia Escherichia NNP cord-354900-bzv4yhqi 38 25 coli coli NNS cord-354900-bzv4yhqi 38 26 populations population NNS cord-354900-bzv4yhqi 38 27 , , , cord-354900-bzv4yhqi 38 28 and and CC cord-354900-bzv4yhqi 38 29 modulated modulate VBD cord-354900-bzv4yhqi 38 30 the the DT cord-354900-bzv4yhqi 38 31 production production NN cord-354900-bzv4yhqi 38 32 of of IN cord-354900-bzv4yhqi 38 33 inflammatory inflammatory JJ cord-354900-bzv4yhqi 38 34 mediators mediator NNS cord-354900-bzv4yhqi 38 35 [ [ -LRB- cord-354900-bzv4yhqi 38 36 31 31 CD cord-354900-bzv4yhqi 38 37 ] ] -RRB- cord-354900-bzv4yhqi 38 38 . . . cord-354900-bzv4yhqi 39 1 β β LS cord-354900-bzv4yhqi 39 2 - - HYPH cord-354900-bzv4yhqi 39 3 glucan glucan JJ cord-354900-bzv4yhqi 39 4 administration administration NN cord-354900-bzv4yhqi 39 5 increased increase VBD cord-354900-bzv4yhqi 39 6 the the DT cord-354900-bzv4yhqi 39 7 production production NN cord-354900-bzv4yhqi 39 8 of of IN cord-354900-bzv4yhqi 39 9 IL-10 IL-10 NNP cord-354900-bzv4yhqi 39 10 via via IN cord-354900-bzv4yhqi 39 11 activation activation NN cord-354900-bzv4yhqi 39 12 of of IN cord-354900-bzv4yhqi 39 13 PPARγ PPARγ NNS cord-354900-bzv4yhqi 39 14 , , , cord-354900-bzv4yhqi 39 15 favouring favour VBG cord-354900-bzv4yhqi 39 16 the the DT cord-354900-bzv4yhqi 39 17 clearance clearance NN cord-354900-bzv4yhqi 39 18 of of IN cord-354900-bzv4yhqi 39 19 Candida Candida NNP cord-354900-bzv4yhqi 39 20 glabrata glabrata NN cord-354900-bzv4yhqi 39 21 from from IN cord-354900-bzv4yhqi 39 22 the the DT cord-354900-bzv4yhqi 39 23 gut gut NN cord-354900-bzv4yhqi 39 24 and and CC cord-354900-bzv4yhqi 39 25 the the DT cord-354900-bzv4yhqi 39 26 reduction reduction NN cord-354900-bzv4yhqi 39 27 of of IN cord-354900-bzv4yhqi 39 28 diarrhoea diarrhoea NN cord-354900-bzv4yhqi 39 29 and and CC cord-354900-bzv4yhqi 39 30 colitis colitis NN cord-354900-bzv4yhqi 39 31 [ [ -LRB- cord-354900-bzv4yhqi 39 32 31 31 CD cord-354900-bzv4yhqi 39 33 ] ] -RRB- cord-354900-bzv4yhqi 39 34 . . . cord-354900-bzv4yhqi 40 1 In in IN cord-354900-bzv4yhqi 40 2 line line NN cord-354900-bzv4yhqi 40 3 with with IN cord-354900-bzv4yhqi 40 4 this this DT cord-354900-bzv4yhqi 40 5 observation observation NN cord-354900-bzv4yhqi 40 6 , , , cord-354900-bzv4yhqi 40 7 we -PRON- PRP cord-354900-bzv4yhqi 40 8 showed show VBD cord-354900-bzv4yhqi 40 9 that that IN cord-354900-bzv4yhqi 40 10 in in IN cord-354900-bzv4yhqi 40 11 contrast contrast NN cord-354900-bzv4yhqi 40 12 to to IN cord-354900-bzv4yhqi 40 13 mannoprotein mannoprotein NNP cord-354900-bzv4yhqi 40 14 extracts extract NNS cord-354900-bzv4yhqi 40 15 , , , cord-354900-bzv4yhqi 40 16 oral oral JJ cord-354900-bzv4yhqi 40 17 administration administration NN cord-354900-bzv4yhqi 40 18 of of IN cord-354900-bzv4yhqi 40 19 β β NNP cord-354900-bzv4yhqi 40 20 - - HYPH cord-354900-bzv4yhqi 40 21 glucan glucan NN cord-354900-bzv4yhqi 40 22 derived derive VBN cord-354900-bzv4yhqi 40 23 from from IN cord-354900-bzv4yhqi 40 24 S. S. NNP cord-354900-bzv4yhqi 40 25 cerevisiae cerevisiae NNS cord-354900-bzv4yhqi 40 26 reduced reduce VBN cord-354900-bzv4yhqi 40 27 intestinal intestinal JJ cord-354900-bzv4yhqi 40 28 inflammation inflammation NN cord-354900-bzv4yhqi 40 29 and and CC cord-354900-bzv4yhqi 40 30 promoted promote VBD cord-354900-bzv4yhqi 40 31 the the DT cord-354900-bzv4yhqi 40 32 reduction reduction NN cord-354900-bzv4yhqi 40 33 of of IN cord-354900-bzv4yhqi 40 34 C. C. NNP cord-354900-bzv4yhqi 40 35 albicans albican NNS cord-354900-bzv4yhqi 40 36 overgrowth overgrowth NN cord-354900-bzv4yhqi 40 37 in in IN cord-354900-bzv4yhqi 40 38 the the DT cord-354900-bzv4yhqi 40 39 gut gut NN cord-354900-bzv4yhqi 40 40 [ [ -LRB- cord-354900-bzv4yhqi 40 41 23 23 CD cord-354900-bzv4yhqi 40 42 ] ] -RRB- cord-354900-bzv4yhqi 40 43 . . . cord-354900-bzv4yhqi 41 1 In in IN cord-354900-bzv4yhqi 41 2 terms term NNS cord-354900-bzv4yhqi 41 3 of of IN cord-354900-bzv4yhqi 41 4 the the DT cord-354900-bzv4yhqi 41 5 effect effect NN cord-354900-bzv4yhqi 41 6 of of IN cord-354900-bzv4yhqi 41 7 β β NN cord-354900-bzv4yhqi 41 8 - - HYPH cord-354900-bzv4yhqi 41 9 glucans glucan NNS cord-354900-bzv4yhqi 41 10 on on IN cord-354900-bzv4yhqi 41 11 viral viral JJ cord-354900-bzv4yhqi 41 12 infections infection NNS cord-354900-bzv4yhqi 41 13 , , , cord-354900-bzv4yhqi 41 14 administration administration NN cord-354900-bzv4yhqi 41 15 of of IN cord-354900-bzv4yhqi 41 16 S. S. NNP cord-354900-bzv4yhqi 41 17 cerevisiae cerevisiae NN cord-354900-bzv4yhqi 41 18 β β NN cord-354900-bzv4yhqi 41 19 - - HYPH cord-354900-bzv4yhqi 41 20 glucan glucan NN cord-354900-bzv4yhqi 41 21 decreased decrease VBD cord-354900-bzv4yhqi 41 22 pulmonary pulmonary JJ cord-354900-bzv4yhqi 41 23 lesion lesion NN cord-354900-bzv4yhqi 41 24 score score NN cord-354900-bzv4yhqi 41 25 and and CC cord-354900-bzv4yhqi 41 26 viral viral JJ cord-354900-bzv4yhqi 41 27 replication replication NN cord-354900-bzv4yhqi 41 28 , , , cord-354900-bzv4yhqi 41 29 and and CC cord-354900-bzv4yhqi 41 30 increased increase VBD cord-354900-bzv4yhqi 41 31 IFN IFN NNP cord-354900-bzv4yhqi 41 32 - - HYPH cord-354900-bzv4yhqi 41 33 γ γ NNP cord-354900-bzv4yhqi 41 34 and and CC cord-354900-bzv4yhqi 41 35 NO no DT cord-354900-bzv4yhqi 41 36 levels level NNS cord-354900-bzv4yhqi 41 37 in in IN cord-354900-bzv4yhqi 41 38 pigs pig NNS cord-354900-bzv4yhqi 41 39 infected infect VBN cord-354900-bzv4yhqi 41 40 with with IN cord-354900-bzv4yhqi 41 41 swine swine NN cord-354900-bzv4yhqi 41 42 influenza influenza NN cord-354900-bzv4yhqi 41 43 virus virus NN cord-354900-bzv4yhqi 41 44 , , , cord-354900-bzv4yhqi 41 45 indicating indicate VBG cord-354900-bzv4yhqi 41 46 the the DT cord-354900-bzv4yhqi 41 47 role role NN cord-354900-bzv4yhqi 41 48 of of IN cord-354900-bzv4yhqi 41 49 β β NN cord-354900-bzv4yhqi 41 50 - - HYPH cord-354900-bzv4yhqi 41 51 glucan glucan NNP cord-354900-bzv4yhqi 41 52 as as IN cord-354900-bzv4yhqi 41 53 a a DT cord-354900-bzv4yhqi 41 54 prophylactic prophylactic JJ cord-354900-bzv4yhqi 41 55 option option NN cord-354900-bzv4yhqi 41 56 in in IN cord-354900-bzv4yhqi 41 57 decreasing decrease VBG cord-354900-bzv4yhqi 41 58 of of IN cord-354900-bzv4yhqi 41 59 influenza influenza NN cord-354900-bzv4yhqi 41 60 virus virus NN cord-354900-bzv4yhqi 41 61 infection infection NN cord-354900-bzv4yhqi 41 62 [ [ -LRB- cord-354900-bzv4yhqi 41 63 32 32 CD cord-354900-bzv4yhqi 41 64 ] ] -RRB- cord-354900-bzv4yhqi 41 65 . . . cord-354900-bzv4yhqi 42 1 In in IN cord-354900-bzv4yhqi 42 2 line line NN cord-354900-bzv4yhqi 42 3 with with IN cord-354900-bzv4yhqi 42 4 this this DT cord-354900-bzv4yhqi 42 5 observation observation NN cord-354900-bzv4yhqi 42 6 , , , cord-354900-bzv4yhqi 42 7 young young JJ cord-354900-bzv4yhqi 42 8 piglets piglet NNS cord-354900-bzv4yhqi 42 9 were be VBD cord-354900-bzv4yhqi 42 10 exposed expose VBN cord-354900-bzv4yhqi 42 11 to to IN cord-354900-bzv4yhqi 42 12 porcine porcine JJ cord-354900-bzv4yhqi 42 13 reproductive reproductive JJ cord-354900-bzv4yhqi 42 14 and and CC cord-354900-bzv4yhqi 42 15 respiratory respiratory JJ cord-354900-bzv4yhqi 42 16 syndrome syndrome NN cord-354900-bzv4yhqi 42 17 virus virus NN cord-354900-bzv4yhqi 42 18 and and CC cord-354900-bzv4yhqi 42 19 peripheral peripheral JJ cord-354900-bzv4yhqi 42 20 blood blood NN cord-354900-bzv4yhqi 42 21 monocytes monocyte NNS cord-354900-bzv4yhqi 42 22 were be VBD cord-354900-bzv4yhqi 42 23 then then RB cord-354900-bzv4yhqi 42 24 isolated isolate VBN cord-354900-bzv4yhqi 42 25 and and CC cord-354900-bzv4yhqi 42 26 exposed expose VBN cord-354900-bzv4yhqi 42 27 to to IN cord-354900-bzv4yhqi 42 28 varying vary VBG cord-354900-bzv4yhqi 42 29 concentrations concentration NNS cord-354900-bzv4yhqi 42 30 of of IN cord-354900-bzv4yhqi 42 31 β β NN cord-354900-bzv4yhqi 42 32 - - HYPH cord-354900-bzv4yhqi 42 33 glucan glucan JJ cord-354900-bzv4yhqi 42 34 [ [ -LRB- cord-354900-bzv4yhqi 42 35 33 33 CD cord-354900-bzv4yhqi 42 36 ] ] -RRB- cord-354900-bzv4yhqi 42 37 . . . cord-354900-bzv4yhqi 43 1 β β NN cord-354900-bzv4yhqi 43 2 - - HYPH cord-354900-bzv4yhqi 43 3 glucan glucan NN cord-354900-bzv4yhqi 43 4 induced induce VBD cord-354900-bzv4yhqi 43 5 the the DT cord-354900-bzv4yhqi 43 6 production production NN cord-354900-bzv4yhqi 43 7 of of IN cord-354900-bzv4yhqi 43 8 IFN IFN NNP cord-354900-bzv4yhqi 43 9 - - HYPH cord-354900-bzv4yhqi 43 10 γ γ NNP cord-354900-bzv4yhqi 43 11 in in IN cord-354900-bzv4yhqi 43 12 a a DT cord-354900-bzv4yhqi 43 13 dose dose NN cord-354900-bzv4yhqi 43 14 - - HYPH cord-354900-bzv4yhqi 43 15 dependent dependent JJ cord-354900-bzv4yhqi 43 16 manner manner NN cord-354900-bzv4yhqi 43 17 , , , cord-354900-bzv4yhqi 43 18 suggesting suggest VBG cord-354900-bzv4yhqi 43 19 that that IN cord-354900-bzv4yhqi 43 20 soluble soluble JJ cord-354900-bzv4yhqi 43 21 β β NN cord-354900-bzv4yhqi 43 22 - - HYPH cord-354900-bzv4yhqi 43 23 glucan glucan NN cord-354900-bzv4yhqi 43 24 may may MD cord-354900-bzv4yhqi 43 25 improve improve VB cord-354900-bzv4yhqi 43 26 the the DT cord-354900-bzv4yhqi 43 27 innate innate JJ cord-354900-bzv4yhqi 43 28 immune immune JJ cord-354900-bzv4yhqi 43 29 response response NN cord-354900-bzv4yhqi 43 30 against against IN cord-354900-bzv4yhqi 43 31 this this DT cord-354900-bzv4yhqi 43 32 virus virus NN cord-354900-bzv4yhqi 43 33 [ [ -LRB- cord-354900-bzv4yhqi 43 34 33 33 CD cord-354900-bzv4yhqi 43 35 ] ] -RRB- cord-354900-bzv4yhqi 43 36 . . . cord-354900-bzv4yhqi 44 1 Additionally additionally RB cord-354900-bzv4yhqi 44 2 , , , cord-354900-bzv4yhqi 44 3 the the DT cord-354900-bzv4yhqi 44 4 administration administration NN cord-354900-bzv4yhqi 44 5 of of IN cord-354900-bzv4yhqi 44 6 β β NNP cord-354900-bzv4yhqi 44 7 - - HYPH cord-354900-bzv4yhqi 44 8 glucans glucan NNS cord-354900-bzv4yhqi 44 9 contained contain VBN cord-354900-bzv4yhqi 44 10 in in IN cord-354900-bzv4yhqi 44 11 the the DT cord-354900-bzv4yhqi 44 12 culture culture NN cord-354900-bzv4yhqi 44 13 fluid fluid NN cord-354900-bzv4yhqi 44 14 of of IN cord-354900-bzv4yhqi 44 15 the the DT cord-354900-bzv4yhqi 44 16 yeast yeast NN cord-354900-bzv4yhqi 44 17 Aureobasidium Aureobasidium NNP cord-354900-bzv4yhqi 44 18 pullulans pullulan NNS cord-354900-bzv4yhqi 44 19 significantly significantly RB cord-354900-bzv4yhqi 44 20 increased increase VBD cord-354900-bzv4yhqi 44 21 the the DT cord-354900-bzv4yhqi 44 22 survival survival NN cord-354900-bzv4yhqi 44 23 of of IN cord-354900-bzv4yhqi 44 24 mice mouse NNS cord-354900-bzv4yhqi 44 25 after after IN cord-354900-bzv4yhqi 44 26 sub sub JJ cord-354900-bzv4yhqi 44 27 - - JJ cord-354900-bzv4yhqi 44 28 lethal lethal JJ cord-354900-bzv4yhqi 44 29 infection infection NN cord-354900-bzv4yhqi 44 30 with with IN cord-354900-bzv4yhqi 44 31 the the DT cord-354900-bzv4yhqi 44 32 PR8-H1N1 PR8-H1N1 NNP cord-354900-bzv4yhqi 44 33 strain strain NN cord-354900-bzv4yhqi 44 34 of of IN cord-354900-bzv4yhqi 44 35 influenza influenza NN cord-354900-bzv4yhqi 44 36 virus virus NN cord-354900-bzv4yhqi 44 37 [ [ -LRB- cord-354900-bzv4yhqi 44 38 34 34 CD cord-354900-bzv4yhqi 44 39 ] ] -RRB- cord-354900-bzv4yhqi 44 40 . . . cord-354900-bzv4yhqi 45 1 Horst Horst NNP cord-354900-bzv4yhqi 45 2 et et NNP cord-354900-bzv4yhqi 45 3 al al NNP cord-354900-bzv4yhqi 45 4 . . NNP cord-354900-bzv4yhqi 45 5 showed show VBD cord-354900-bzv4yhqi 45 6 that that IN cord-354900-bzv4yhqi 45 7 daily daily JJ cord-354900-bzv4yhqi 45 8 dietary dietary JJ cord-354900-bzv4yhqi 45 9 supplementation supplementation NN cord-354900-bzv4yhqi 45 10 with with IN cord-354900-bzv4yhqi 45 11 β-1,3-glucan β-1,3-glucan NNP cord-354900-bzv4yhqi 45 12 improved improve VBD cord-354900-bzv4yhqi 45 13 the the DT cord-354900-bzv4yhqi 45 14 vaccination vaccination NN cord-354900-bzv4yhqi 45 15 response response NN cord-354900-bzv4yhqi 45 16 to to IN cord-354900-bzv4yhqi 45 17 Newcastle Newcastle NNP cord-354900-bzv4yhqi 45 18 disease disease NN cord-354900-bzv4yhqi 45 19 virus virus NN cord-354900-bzv4yhqi 45 20 in in IN cord-354900-bzv4yhqi 45 21 chickens chicken NNS cord-354900-bzv4yhqi 45 22 [ [ -LRB- cord-354900-bzv4yhqi 45 23 35 35 CD cord-354900-bzv4yhqi 45 24 ] ] -RRB- cord-354900-bzv4yhqi 45 25 . . . cord-354900-bzv4yhqi 46 1 With with IN cord-354900-bzv4yhqi 46 2 regard regard NN cord-354900-bzv4yhqi 46 3 to to IN cord-354900-bzv4yhqi 46 4 the the DT cord-354900-bzv4yhqi 46 5 comparison comparison NN cord-354900-bzv4yhqi 46 6 of of IN cord-354900-bzv4yhqi 46 7 intense intense JJ cord-354900-bzv4yhqi 46 8 versus versus IN cord-354900-bzv4yhqi 46 9 moderate moderate JJ cord-354900-bzv4yhqi 46 10 exercise exercise NN cord-354900-bzv4yhqi 46 11 , , , cord-354900-bzv4yhqi 46 12 in in IN cord-354900-bzv4yhqi 46 13 contrast contrast NN cord-354900-bzv4yhqi 46 14 to to IN cord-354900-bzv4yhqi 46 15 moderate moderate JJ cord-354900-bzv4yhqi 46 16 exercise exercise NN cord-354900-bzv4yhqi 46 17 that that WDT cord-354900-bzv4yhqi 46 18 may may MD cord-354900-bzv4yhqi 46 19 improve improve VB cord-354900-bzv4yhqi 46 20 immune immune JJ cord-354900-bzv4yhqi 46 21 function function NN cord-354900-bzv4yhqi 46 22 , , , cord-354900-bzv4yhqi 46 23 the the DT cord-354900-bzv4yhqi 46 24 high high JJ cord-354900-bzv4yhqi 46 25 - - HYPH cord-354900-bzv4yhqi 46 26 intensity intensity NN cord-354900-bzv4yhqi 46 27 exercise exercise NN cord-354900-bzv4yhqi 46 28 such such JJ cord-354900-bzv4yhqi 46 29 as as IN cord-354900-bzv4yhqi 46 30 a a DT cord-354900-bzv4yhqi 46 31 marathon marathon NN cord-354900-bzv4yhqi 46 32 , , , cord-354900-bzv4yhqi 46 33 can can MD cord-354900-bzv4yhqi 46 34 temporarily temporarily RB cord-354900-bzv4yhqi 46 35 suppress suppress VB cord-354900-bzv4yhqi 46 36 mucosal mucosal JJ cord-354900-bzv4yhqi 46 37 immunity immunity NN cord-354900-bzv4yhqi 46 38 , , , cord-354900-bzv4yhqi 46 39 and and CC cord-354900-bzv4yhqi 46 40 increase increase VB cord-354900-bzv4yhqi 46 41 the the DT cord-354900-bzv4yhqi 46 42 risk risk NN cord-354900-bzv4yhqi 46 43 of of IN cord-354900-bzv4yhqi 46 44 developing develop VBG cord-354900-bzv4yhqi 46 45 upper upper JJ cord-354900-bzv4yhqi 46 46 respiratory respiratory JJ cord-354900-bzv4yhqi 46 47 tract tract NN cord-354900-bzv4yhqi 46 48 infections infection NNS cord-354900-bzv4yhqi 46 49 [ [ -LRB- cord-354900-bzv4yhqi 46 50 36 36 CD cord-354900-bzv4yhqi 46 51 ] ] -RRB- cord-354900-bzv4yhqi 46 52 . . . cord-354900-bzv4yhqi 47 1 Administration administration NN cord-354900-bzv4yhqi 47 2 of of IN cord-354900-bzv4yhqi 47 3 βglucan βglucan NNP cord-354900-bzv4yhqi 47 4 - - HYPH cord-354900-bzv4yhqi 47 5 derived derive VBN cord-354900-bzv4yhqi 47 6 from from IN cord-354900-bzv4yhqi 47 7 yeast yeast NN cord-354900-bzv4yhqi 47 8 induced induce VBN cord-354900-bzv4yhqi 47 9 the the DT cord-354900-bzv4yhqi 47 10 production production NN cord-354900-bzv4yhqi 47 11 of of IN cord-354900-bzv4yhqi 47 12 salivary salivary NN cord-354900-bzv4yhqi 47 13 immunoglobulin immunoglobulin NN cord-354900-bzv4yhqi 47 14 A a NN cord-354900-bzv4yhqi 47 15 and and CC cord-354900-bzv4yhqi 47 16 reduced reduce VBN cord-354900-bzv4yhqi 47 17 cold cold JJ cord-354900-bzv4yhqi 47 18 / / SYM cord-354900-bzv4yhqi 47 19 flu flu NN cord-354900-bzv4yhqi 47 20 symptomatic symptomatic JJ cord-354900-bzv4yhqi 47 21 days day NNS cord-354900-bzv4yhqi 47 22 after after IN cord-354900-bzv4yhqi 47 23 intense intense JJ cord-354900-bzv4yhqi 47 24 exercise exercise NN cord-354900-bzv4yhqi 47 25 stress stress NN cord-354900-bzv4yhqi 47 26 in in IN cord-354900-bzv4yhqi 47 27 a a DT cord-354900-bzv4yhqi 47 28 cohort cohort NN cord-354900-bzv4yhqi 47 29 of of IN cord-354900-bzv4yhqi 47 30 182 182 CD cord-354900-bzv4yhqi 47 31 individuals individual NNS cord-354900-bzv4yhqi 47 32 [ [ -LRB- cord-354900-bzv4yhqi 47 33 36 36 CD cord-354900-bzv4yhqi 47 34 ] ] -RRB- cord-354900-bzv4yhqi 47 35 . . . cord-354900-bzv4yhqi 48 1 Further further JJ cord-354900-bzv4yhqi 48 2 investigations investigation NNS cord-354900-bzv4yhqi 48 3 showed show VBD cord-354900-bzv4yhqi 48 4 that that IN cord-354900-bzv4yhqi 48 5 β β NN cord-354900-bzv4yhqi 48 6 - - HYPH cord-354900-bzv4yhqi 48 7 glucan glucan JJ cord-354900-bzv4yhqi 48 8 supplementation supplementation NN cord-354900-bzv4yhqi 48 9 decreased decrease VBD cord-354900-bzv4yhqi 48 10 upper upper JJ cord-354900-bzv4yhqi 48 11 respiratory respiratory JJ cord-354900-bzv4yhqi 48 12 tract tract NN cord-354900-bzv4yhqi 48 13 infections infection NNS cord-354900-bzv4yhqi 48 14 and and CC cord-354900-bzv4yhqi 48 15 improved improved JJ cord-354900-bzv4yhqi 48 16 mood mood NN cord-354900-bzv4yhqi 48 17 state state NN cord-354900-bzv4yhqi 48 18 in in IN cord-354900-bzv4yhqi 48 19 stressed stress VBN cord-354900-bzv4yhqi 48 20 individuals individual NNS cord-354900-bzv4yhqi 48 21 , , , cord-354900-bzv4yhqi 48 22 suggesting suggest VBG cord-354900-bzv4yhqi 48 23 that that IN cord-354900-bzv4yhqi 48 24 it -PRON- PRP cord-354900-bzv4yhqi 48 25 may may MD cord-354900-bzv4yhqi 48 26 be be VB cord-354900-bzv4yhqi 48 27 a a DT cord-354900-bzv4yhqi 48 28 useful useful JJ cord-354900-bzv4yhqi 48 29 approach approach NN cord-354900-bzv4yhqi 48 30 for for IN cord-354900-bzv4yhqi 48 31 reinforcing reinforce VBG cord-354900-bzv4yhqi 48 32 immune immune JJ cord-354900-bzv4yhqi 48 33 response response NN cord-354900-bzv4yhqi 48 34 against against IN cord-354900-bzv4yhqi 48 35 daily daily JJ cord-354900-bzv4yhqi 48 36 stressors stressor NNS cord-354900-bzv4yhqi 48 37 [ [ -LRB- cord-354900-bzv4yhqi 48 38 37 37 CD cord-354900-bzv4yhqi 48 39 ] ] -RRB- cord-354900-bzv4yhqi 48 40 . . . cord-354900-bzv4yhqi 49 1 Multiple multiple JJ cord-354900-bzv4yhqi 49 2 lines line NNS cord-354900-bzv4yhqi 49 3 of of IN cord-354900-bzv4yhqi 49 4 evidence evidence NN cord-354900-bzv4yhqi 49 5 showed show VBD cord-354900-bzv4yhqi 49 6 that that IN cord-354900-bzv4yhqi 49 7 β β NN cord-354900-bzv4yhqi 49 8 - - HYPH cord-354900-bzv4yhqi 49 9 glucans glucan NNS cord-354900-bzv4yhqi 49 10 derived derive VBN cord-354900-bzv4yhqi 49 11 from from IN cord-354900-bzv4yhqi 49 12 yeasts yeast NNS cord-354900-bzv4yhqi 49 13 can can MD cord-354900-bzv4yhqi 49 14 block block VB cord-354900-bzv4yhqi 49 15 or or CC cord-354900-bzv4yhqi 49 16 activate activate VB cord-354900-bzv4yhqi 49 17 many many JJ cord-354900-bzv4yhqi 49 18 immune immune JJ cord-354900-bzv4yhqi 49 19 receptors receptor NNS cord-354900-bzv4yhqi 49 20 such such JJ cord-354900-bzv4yhqi 49 21 as as IN cord-354900-bzv4yhqi 49 22 dectin-1 dectin-1 NNP cord-354900-bzv4yhqi 49 23 , , , cord-354900-bzv4yhqi 49 24 CD11b CD11b NNPS cord-354900-bzv4yhqi 49 25 / / SYM cord-354900-bzv4yhqi 49 26 CD18 CD18 NNP cord-354900-bzv4yhqi 49 27 , , , cord-354900-bzv4yhqi 49 28 or or CC cord-354900-bzv4yhqi 49 29 TLRs TLRs NNPS cord-354900-bzv4yhqi 49 30 [ [ -LRB- cord-354900-bzv4yhqi 49 31 38 38 CD cord-354900-bzv4yhqi 49 32 , , , cord-354900-bzv4yhqi 49 33 39 39 CD cord-354900-bzv4yhqi 49 34 ] ] -RRB- cord-354900-bzv4yhqi 49 35 . . . cord-354900-bzv4yhqi 50 1 These these DT cord-354900-bzv4yhqi 50 2 studies study NNS cord-354900-bzv4yhqi 50 3 are be VBP cord-354900-bzv4yhqi 50 4 consistent consistent JJ cord-354900-bzv4yhqi 50 5 with with IN cord-354900-bzv4yhqi 50 6 our -PRON- PRP$ cord-354900-bzv4yhqi 50 7 previous previous JJ cord-354900-bzv4yhqi 50 8 reports report NNS cord-354900-bzv4yhqi 50 9 showing show VBG cord-354900-bzv4yhqi 50 10 that that IN cord-354900-bzv4yhqi 50 11 soluble soluble JJ cord-354900-bzv4yhqi 50 12 β β NN cord-354900-bzv4yhqi 50 13 - - HYPH cord-354900-bzv4yhqi 50 14 glucans glucan NNS cord-354900-bzv4yhqi 50 15 derived derive VBN cord-354900-bzv4yhqi 50 16 from from IN cord-354900-bzv4yhqi 50 17 yeasts yeast NNS cord-354900-bzv4yhqi 50 18 are be VBP cord-354900-bzv4yhqi 50 19 able able JJ cord-354900-bzv4yhqi 50 20 to to TO cord-354900-bzv4yhqi 50 21 modulate modulate VB cord-354900-bzv4yhqi 50 22 the the DT cord-354900-bzv4yhqi 50 23 activation activation NN cord-354900-bzv4yhqi 50 24 of of IN cord-354900-bzv4yhqi 50 25 platelets platelet NNS cord-354900-bzv4yhqi 50 26 mediated mediate VBN cord-354900-bzv4yhqi 50 27 by by IN cord-354900-bzv4yhqi 50 28 TLR4 TLR4 NNP cord-354900-bzv4yhqi 50 29 expression expression NN cord-354900-bzv4yhqi 50 30 [ [ -LRB- cord-354900-bzv4yhqi 50 31 40 40 CD cord-354900-bzv4yhqi 50 32 ] ] -RRB- cord-354900-bzv4yhqi 50 33 . . . cord-354900-bzv4yhqi 51 1 In in IN cord-354900-bzv4yhqi 51 2 this this DT cord-354900-bzv4yhqi 51 3 study study NN cord-354900-bzv4yhqi 51 4 , , , cord-354900-bzv4yhqi 51 5 we -PRON- PRP cord-354900-bzv4yhqi 51 6 showed show VBD cord-354900-bzv4yhqi 51 7 that that IN cord-354900-bzv4yhqi 51 8 β β NN cord-354900-bzv4yhqi 51 9 - - HYPH cord-354900-bzv4yhqi 51 10 glucans glucan NNS cord-354900-bzv4yhqi 51 11 at at IN cord-354900-bzv4yhqi 51 12 a a DT cord-354900-bzv4yhqi 51 13 low low JJ cord-354900-bzv4yhqi 51 14 concentration concentration NN cord-354900-bzv4yhqi 51 15 in in IN cord-354900-bzv4yhqi 51 16 plasma plasma NN cord-354900-bzv4yhqi 51 17 decreases decrease NNS cord-354900-bzv4yhqi 52 1 thrombin thrombin JJ cord-354900-bzv4yhqi 52 2 production production NN cord-354900-bzv4yhqi 52 3 and and CC cord-354900-bzv4yhqi 52 4 the the DT cord-354900-bzv4yhqi 52 5 progressive progressive JJ cord-354900-bzv4yhqi 52 6 increase increase NN cord-354900-bzv4yhqi 52 7 in in IN cord-354900-bzv4yhqi 52 8 β β NN cord-354900-bzv4yhqi 52 9 - - HYPH cord-354900-bzv4yhqi 52 10 glucan glucan JJ cord-354900-bzv4yhqi 52 11 concentration concentration NN cord-354900-bzv4yhqi 52 12 in in IN cord-354900-bzv4yhqi 52 13 plasma plasma NN cord-354900-bzv4yhqi 52 14 reduces reduce VBZ cord-354900-bzv4yhqi 52 15 coagulation coagulation NN cord-354900-bzv4yhqi 52 16 until until IN cord-354900-bzv4yhqi 52 17 these these DT cord-354900-bzv4yhqi 52 18 β β NN cord-354900-bzv4yhqi 52 19 - - HYPH cord-354900-bzv4yhqi 52 20 glucan glucan NN cord-354900-bzv4yhqi 52 21 fractions fraction NNS cord-354900-bzv4yhqi 52 22 no no RB cord-354900-bzv4yhqi 52 23 longer longer RB cord-354900-bzv4yhqi 52 24 affect affect VBP cord-354900-bzv4yhqi 52 25 thrombin thrombin JJ cord-354900-bzv4yhqi 52 26 production production NN cord-354900-bzv4yhqi 52 27 indicating indicate VBG cord-354900-bzv4yhqi 52 28 that that IN cord-354900-bzv4yhqi 52 29 β β NN cord-354900-bzv4yhqi 52 30 - - HYPH cord-354900-bzv4yhqi 52 31 glucan glucan JJ cord-354900-bzv4yhqi 52 32 fractions fraction NNS cord-354900-bzv4yhqi 52 33 have have VBP cord-354900-bzv4yhqi 52 34 activity activity NN cord-354900-bzv4yhqi 52 35 that that WDT cord-354900-bzv4yhqi 52 36 is be VBZ cord-354900-bzv4yhqi 52 37 similar similar JJ cord-354900-bzv4yhqi 52 38 to to IN cord-354900-bzv4yhqi 52 39 that that DT cord-354900-bzv4yhqi 52 40 of of IN cord-354900-bzv4yhqi 52 41 low low JJ cord-354900-bzv4yhqi 52 42 molecular molecular JJ cord-354900-bzv4yhqi 52 43 weight weight NN cord-354900-bzv4yhqi 52 44 heparin heparin NN cord-354900-bzv4yhqi 52 45 [ [ -LRB- cord-354900-bzv4yhqi 52 46 40 40 CD cord-354900-bzv4yhqi 52 47 ] ] -RRB- cord-354900-bzv4yhqi 52 48 . . . cord-354900-bzv4yhqi 53 1 Additionally additionally RB cord-354900-bzv4yhqi 53 2 , , , cord-354900-bzv4yhqi 53 3 β β NN cord-354900-bzv4yhqi 53 4 - - HYPH cord-354900-bzv4yhqi 53 5 glucan glucan JJ cord-354900-bzv4yhqi 53 6 fractions fraction NNS cord-354900-bzv4yhqi 53 7 decreased decrease VBD cord-354900-bzv4yhqi 53 8 the the DT cord-354900-bzv4yhqi 53 9 platelet platelet NN cord-354900-bzv4yhqi 53 10 aggregation aggregation NN cord-354900-bzv4yhqi 53 11 and and CC cord-354900-bzv4yhqi 53 12 the the DT cord-354900-bzv4yhqi 53 13 expression expression NN cord-354900-bzv4yhqi 53 14 of of IN cord-354900-bzv4yhqi 53 15 receptors receptor NNS cord-354900-bzv4yhqi 53 16 such such JJ cord-354900-bzv4yhqi 53 17 as as IN cord-354900-bzv4yhqi 53 18 P p NN cord-354900-bzv4yhqi 53 19 - - HYPH cord-354900-bzv4yhqi 53 20 selectin selectin NN cord-354900-bzv4yhqi 53 21 and and CC cord-354900-bzv4yhqi 53 22 activation activation NN cord-354900-bzv4yhqi 53 23 of of IN cord-354900-bzv4yhqi 53 24 integrin integrin NN cord-354900-bzv4yhqi 53 25 αIIbβ3 αIIbβ3 NNP cord-354900-bzv4yhqi 53 26 . . . cord-354900-bzv4yhqi 54 1 It -PRON- PRP cord-354900-bzv4yhqi 54 2 also also RB cord-354900-bzv4yhqi 54 3 reduced reduce VBD cord-354900-bzv4yhqi 54 4 platelet platelet NN cord-354900-bzv4yhqi 54 5 activation activation NN cord-354900-bzv4yhqi 54 6 mediated mediate VBN cord-354900-bzv4yhqi 54 7 by by IN cord-354900-bzv4yhqi 54 8 TLR4 TLR4 NNP cord-354900-bzv4yhqi 54 9 by by IN cord-354900-bzv4yhqi 54 10 increasing increase VBG cord-354900-bzv4yhqi 54 11 the the DT cord-354900-bzv4yhqi 54 12 production production NN cord-354900-bzv4yhqi 54 13 of of IN cord-354900-bzv4yhqi 54 14 TGF TGF NNP cord-354900-bzv4yhqi 54 15 - - HYPH cord-354900-bzv4yhqi 54 16 β1 β1 NNP cord-354900-bzv4yhqi 54 17 and and CC cord-354900-bzv4yhqi 54 18 release release NN cord-354900-bzv4yhqi 54 19 of of IN cord-354900-bzv4yhqi 54 20 ATP ATP NNP cord-354900-bzv4yhqi 54 21 [ [ -LRB- cord-354900-bzv4yhqi 54 22 40 40 CD cord-354900-bzv4yhqi 54 23 ] ] -RRB- cord-354900-bzv4yhqi 54 24 . . . cord-354900-bzv4yhqi 55 1 Of of IN cord-354900-bzv4yhqi 55 2 note note NN cord-354900-bzv4yhqi 55 3 , , , cord-354900-bzv4yhqi 55 4 platelets platelet NNS cord-354900-bzv4yhqi 55 5 play play VBP cord-354900-bzv4yhqi 55 6 an an DT cord-354900-bzv4yhqi 55 7 important important JJ cord-354900-bzv4yhqi 55 8 role role NN cord-354900-bzv4yhqi 55 9 in in IN cord-354900-bzv4yhqi 55 10 haemostasis haemostasis NN cord-354900-bzv4yhqi 55 11 , , , cord-354900-bzv4yhqi 55 12 inflammation inflammation NN cord-354900-bzv4yhqi 55 13 and and CC cord-354900-bzv4yhqi 55 14 pathogen pathogen NN cord-354900-bzv4yhqi 55 15 clearance clearance NN cord-354900-bzv4yhqi 55 16 [ [ -LRB- cord-354900-bzv4yhqi 55 17 24 24 CD cord-354900-bzv4yhqi 55 18 ] ] -RRB- cord-354900-bzv4yhqi 55 19 . . . cord-354900-bzv4yhqi 56 1 Recently recently RB cord-354900-bzv4yhqi 56 2 , , , cord-354900-bzv4yhqi 56 3 a a DT cord-354900-bzv4yhqi 56 4 decrease decrease NN cord-354900-bzv4yhqi 56 5 in in IN cord-354900-bzv4yhqi 56 6 platelet platelet NN cord-354900-bzv4yhqi 56 7 count count NN cord-354900-bzv4yhqi 56 8 has have VBZ cord-354900-bzv4yhqi 56 9 been be VBN cord-354900-bzv4yhqi 56 10 observed observe VBN cord-354900-bzv4yhqi 56 11 in in IN cord-354900-bzv4yhqi 56 12 patients patient NNS cord-354900-bzv4yhqi 56 13 with with IN cord-354900-bzv4yhqi 56 14 SARS SARS NNP cord-354900-bzv4yhqi 56 15 - - HYPH cord-354900-bzv4yhqi 56 16 CoV-2 CoV-2 NNP cord-354900-bzv4yhqi 56 17 [ [ -LRB- cord-354900-bzv4yhqi 56 18 41 41 CD cord-354900-bzv4yhqi 56 19 ] ] -RRB- cord-354900-bzv4yhqi 56 20 . . . cord-354900-bzv4yhqi 57 1 These these DT cord-354900-bzv4yhqi 57 2 patients patient NNS cord-354900-bzv4yhqi 57 3 with with IN cord-354900-bzv4yhqi 57 4 COVID-19 COVID-19 NNP cord-354900-bzv4yhqi 57 5 are be VBP cord-354900-bzv4yhqi 57 6 at at IN cord-354900-bzv4yhqi 57 7 high high JJ cord-354900-bzv4yhqi 57 8 risk risk NN cord-354900-bzv4yhqi 57 9 of of IN cord-354900-bzv4yhqi 57 10 developing develop VBG cord-354900-bzv4yhqi 57 11 disseminated disseminate VBN cord-354900-bzv4yhqi 57 12 intravascular intravascular JJ cord-354900-bzv4yhqi 57 13 coagulation coagulation NN cord-354900-bzv4yhqi 57 14 ( ( -LRB- cord-354900-bzv4yhqi 57 15 DIC DIC NNP cord-354900-bzv4yhqi 57 16 ) ) -RRB- cord-354900-bzv4yhqi 57 17 and and CC cord-354900-bzv4yhqi 57 18 both both DT cord-354900-bzv4yhqi 57 19 thrombocytopenia thrombocytopenia NN cord-354900-bzv4yhqi 57 20 and and CC cord-354900-bzv4yhqi 57 21 elevated elevated JJ cord-354900-bzv4yhqi 57 22 D d NN cord-354900-bzv4yhqi 57 23 - - HYPH cord-354900-bzv4yhqi 57 24 dimer dimer NN cord-354900-bzv4yhqi 57 25 are be VBP cord-354900-bzv4yhqi 57 26 induced induce VBN cord-354900-bzv4yhqi 57 27 in in IN cord-354900-bzv4yhqi 57 28 these these DT cord-354900-bzv4yhqi 57 29 patients patient NNS cord-354900-bzv4yhqi 57 30 by by IN cord-354900-bzv4yhqi 57 31 the the DT cord-354900-bzv4yhqi 57 32 excessive excessive JJ cord-354900-bzv4yhqi 57 33 activation activation NN cord-354900-bzv4yhqi 57 34 of of IN cord-354900-bzv4yhqi 57 35 the the DT cord-354900-bzv4yhqi 57 36 coagulation coagulation NN cord-354900-bzv4yhqi 57 37 cascade cascade NN cord-354900-bzv4yhqi 57 38 and and CC cord-354900-bzv4yhqi 57 39 platelets platelet NNS cord-354900-bzv4yhqi 57 40 [ [ -LRB- cord-354900-bzv4yhqi 57 41 42 42 CD cord-354900-bzv4yhqi 57 42 ] ] -RRB- cord-354900-bzv4yhqi 57 43 . . . cord-354900-bzv4yhqi 58 1 Multiple multiple JJ cord-354900-bzv4yhqi 58 2 pathogenetic pathogenetic JJ cord-354900-bzv4yhqi 58 3 mechanisms mechanism NNS cord-354900-bzv4yhqi 58 4 are be VBP cord-354900-bzv4yhqi 58 5 involved involve VBN cord-354900-bzv4yhqi 58 6 , , , cord-354900-bzv4yhqi 58 7 including include VBG cord-354900-bzv4yhqi 58 8 endothelial endothelial JJ cord-354900-bzv4yhqi 58 9 dysfunction dysfunction NN cord-354900-bzv4yhqi 58 10 , , , cord-354900-bzv4yhqi 58 11 von von NNP cord-354900-bzv4yhqi 58 12 Willebrand Willebrand NNP cord-354900-bzv4yhqi 58 13 factor factor NN cord-354900-bzv4yhqi 58 14 elevation elevation NN cord-354900-bzv4yhqi 58 15 , , , cord-354900-bzv4yhqi 58 16 and and CC cord-354900-bzv4yhqi 58 17 TLR TLR NNP cord-354900-bzv4yhqi 58 18 activation activation NN cord-354900-bzv4yhqi 58 19 . . . cord-354900-bzv4yhqi 59 1 These these DT cord-354900-bzv4yhqi 59 2 data datum NNS cord-354900-bzv4yhqi 59 3 suggest suggest VBP cord-354900-bzv4yhqi 59 4 that that IN cord-354900-bzv4yhqi 59 5 the the DT cord-354900-bzv4yhqi 59 6 use use NN cord-354900-bzv4yhqi 59 7 of of IN cord-354900-bzv4yhqi 59 8 prophylactic prophylactic JJ cord-354900-bzv4yhqi 59 9 dose dose NN cord-354900-bzv4yhqi 59 10 low low JJ cord-354900-bzv4yhqi 59 11 molecular molecular JJ cord-354900-bzv4yhqi 59 12 weight weight NN cord-354900-bzv4yhqi 59 13 heparin heparin NN cord-354900-bzv4yhqi 59 14 ( ( -LRB- cord-354900-bzv4yhqi 59 15 LMWH LMWH NNP cord-354900-bzv4yhqi 59 16 ) ) -RRB- cord-354900-bzv4yhqi 59 17 as as IN cord-354900-bzv4yhqi 59 18 prophylaxis prophylaxis NN cord-354900-bzv4yhqi 59 19 and and CC cord-354900-bzv4yhqi 59 20 monitoring monitor VBG cord-354900-bzv4yhqi 59 21 the the DT cord-354900-bzv4yhqi 59 22 coagulation coagulation NN cord-354900-bzv4yhqi 59 23 status status NN cord-354900-bzv4yhqi 59 24 by by IN cord-354900-bzv4yhqi 59 25 measuring measure VBG cord-354900-bzv4yhqi 59 26 prothrombin prothrombin NN cord-354900-bzv4yhqi 59 27 time time NN cord-354900-bzv4yhqi 59 28 , , , cord-354900-bzv4yhqi 59 29 platelet platelet NN cord-354900-bzv4yhqi 59 30 count count NN cord-354900-bzv4yhqi 59 31 , , , cord-354900-bzv4yhqi 59 32 and and CC cord-354900-bzv4yhqi 59 33 D d NN cord-354900-bzv4yhqi 59 34 - - HYPH cord-354900-bzv4yhqi 59 35 dimer dimer NN cord-354900-bzv4yhqi 59 36 concentrations concentration NNS cord-354900-bzv4yhqi 59 37 in in IN cord-354900-bzv4yhqi 59 38 critically critically RB cord-354900-bzv4yhqi 59 39 ill ill JJ cord-354900-bzv4yhqi 59 40 patients patient NNS cord-354900-bzv4yhqi 59 41 with with IN cord-354900-bzv4yhqi 59 42 COVID-19 COVID-19 NNP cord-354900-bzv4yhqi 59 43 [ [ -LRB- cord-354900-bzv4yhqi 59 44 42 42 CD cord-354900-bzv4yhqi 59 45 , , , cord-354900-bzv4yhqi 59 46 43 43 CD cord-354900-bzv4yhqi 59 47 ] ] -RRB- cord-354900-bzv4yhqi 59 48 . . . cord-354900-bzv4yhqi 60 1 In in IN cord-354900-bzv4yhqi 60 2 line line NN cord-354900-bzv4yhqi 60 3 with with IN cord-354900-bzv4yhqi 60 4 these these DT cord-354900-bzv4yhqi 60 5 clinical clinical JJ cord-354900-bzv4yhqi 60 6 observations observation NNS cord-354900-bzv4yhqi 60 7 , , , cord-354900-bzv4yhqi 60 8 severe severe JJ cord-354900-bzv4yhqi 60 9 COVID-19 covid-19 NN cord-354900-bzv4yhqi 60 10 is be VBZ cord-354900-bzv4yhqi 60 11 also also RB cord-354900-bzv4yhqi 60 12 associated associate VBN cord-354900-bzv4yhqi 60 13 with with IN cord-354900-bzv4yhqi 60 14 increased increase VBN cord-354900-bzv4yhqi 60 15 concentrations concentration NNS cord-354900-bzv4yhqi 60 16 of of IN cord-354900-bzv4yhqi 60 17 proinflammatory proinflammatory JJ cord-354900-bzv4yhqi 60 18 cytokines cytokine NNS cord-354900-bzv4yhqi 60 19 including include VBG cord-354900-bzv4yhqi 60 20 IL-6 IL-6 NNP cord-354900-bzv4yhqi 60 21 which which WDT cord-354900-bzv4yhqi 60 22 can can MD cord-354900-bzv4yhqi 60 23 induce induce VB cord-354900-bzv4yhqi 60 24 tissue tissue NN cord-354900-bzv4yhqi 60 25 factor factor NN cord-354900-bzv4yhqi 60 26 expression expression NN cord-354900-bzv4yhqi 60 27 on on IN cord-354900-bzv4yhqi 60 28 mononuclear mononuclear JJ cord-354900-bzv4yhqi 60 29 cells cell NNS cord-354900-bzv4yhqi 60 30 that that WDT cord-354900-bzv4yhqi 60 31 initiates initiate VBZ cord-354900-bzv4yhqi 60 32 coagulation coagulation NN cord-354900-bzv4yhqi 60 33 , , , cord-354900-bzv4yhqi 60 34 platelet platelet NN cord-354900-bzv4yhqi 60 35 activation activation NN cord-354900-bzv4yhqi 60 36 and and CC cord-354900-bzv4yhqi 60 37 thrombin thrombin JJ cord-354900-bzv4yhqi 60 38 generation generation NN cord-354900-bzv4yhqi 60 39 [ [ -LRB- cord-354900-bzv4yhqi 60 40 20 20 CD cord-354900-bzv4yhqi 60 41 ] ] -RRB- cord-354900-bzv4yhqi 60 42 . . . cord-354900-bzv4yhqi 61 1 Recently recently RB cord-354900-bzv4yhqi 61 2 , , , cord-354900-bzv4yhqi 61 3 a a DT cord-354900-bzv4yhqi 61 4 monoclonal monoclonal JJ cord-354900-bzv4yhqi 61 5 antibody antibody NN cord-354900-bzv4yhqi 61 6 against against IN cord-354900-bzv4yhqi 61 7 IL-6 IL-6 NNP cord-354900-bzv4yhqi 61 8 ( ( -LRB- cord-354900-bzv4yhqi 61 9 tocilizumab tocilizumab NNP cord-354900-bzv4yhqi 61 10 ) ) -RRB- cord-354900-bzv4yhqi 61 11 emerged emerge VBD cord-354900-bzv4yhqi 61 12 as as IN cord-354900-bzv4yhqi 61 13 an an DT cord-354900-bzv4yhqi 61 14 alternative alternative JJ cord-354900-bzv4yhqi 61 15 treatment treatment NN cord-354900-bzv4yhqi 61 16 for for IN cord-354900-bzv4yhqi 61 17 COVID-19 covid-19 JJ cord-354900-bzv4yhqi 61 18 patients patient NNS cord-354900-bzv4yhqi 61 19 with with IN cord-354900-bzv4yhqi 61 20 a a DT cord-354900-bzv4yhqi 61 21 risk risk NN cord-354900-bzv4yhqi 61 22 of of IN cord-354900-bzv4yhqi 61 23 cytokine cytokine NN cord-354900-bzv4yhqi 61 24 storms storm NNS cord-354900-bzv4yhqi 61 25 . . . cord-354900-bzv4yhqi 62 1 Guo Guo NNP cord-354900-bzv4yhqi 62 2 et et FW cord-354900-bzv4yhqi 62 3 al al NNP cord-354900-bzv4yhqi 62 4 . . NNP cord-354900-bzv4yhqi 62 5 showed show VBD cord-354900-bzv4yhqi 62 6 that that IN cord-354900-bzv4yhqi 62 7 anti anti JJ cord-354900-bzv4yhqi 62 8 - - JJ cord-354900-bzv4yhqi 62 9 IL-6 il-6 JJ cord-354900-bzv4yhqi 62 10 antibody antibody NN cord-354900-bzv4yhqi 62 11 treatment treatment NN cord-354900-bzv4yhqi 62 12 reduced reduce VBD cord-354900-bzv4yhqi 62 13 the the DT cord-354900-bzv4yhqi 62 14 overreaction overreaction NN cord-354900-bzv4yhqi 62 15 of of IN cord-354900-bzv4yhqi 62 16 the the DT cord-354900-bzv4yhqi 62 17 inflammatory inflammatory JJ cord-354900-bzv4yhqi 62 18 immune immune JJ cord-354900-bzv4yhqi 62 19 responses response NNS cord-354900-bzv4yhqi 62 20 and and CC cord-354900-bzv4yhqi 62 21 boosted boost VBD cord-354900-bzv4yhqi 62 22 immune immune JJ cord-354900-bzv4yhqi 62 23 responses response NNS cord-354900-bzv4yhqi 62 24 mediated mediate VBN cord-354900-bzv4yhqi 62 25 by by IN cord-354900-bzv4yhqi 62 26 B b NN cord-354900-bzv4yhqi 62 27 cells cell NNS cord-354900-bzv4yhqi 62 28 and and CC cord-354900-bzv4yhqi 62 29 CD8 CD8 NNP cord-354900-bzv4yhqi 62 30 + + CC cord-354900-bzv4yhqi 62 31 T T NNP cord-354900-bzv4yhqi 62 32 cells cell NNS cord-354900-bzv4yhqi 62 33 [ [ -LRB- cord-354900-bzv4yhqi 62 34 44 44 CD cord-354900-bzv4yhqi 62 35 ] ] -RRB- cord-354900-bzv4yhqi 62 36 . . . cord-354900-bzv4yhqi 63 1 Currently currently RB cord-354900-bzv4yhqi 63 2 , , , cord-354900-bzv4yhqi 63 3 lifestyle lifestyle NN cord-354900-bzv4yhqi 63 4 changes change NNS cord-354900-bzv4yhqi 63 5 and and CC cord-354900-bzv4yhqi 63 6 psychosocial psychosocial JJ cord-354900-bzv4yhqi 63 7 stress stress NN cord-354900-bzv4yhqi 63 8 caused cause VBN cord-354900-bzv4yhqi 63 9 by by IN cord-354900-bzv4yhqi 63 10 home home NN cord-354900-bzv4yhqi 63 11 confinement confinement NN cord-354900-bzv4yhqi 63 12 during during IN cord-354900-bzv4yhqi 63 13 the the DT cord-354900-bzv4yhqi 63 14 COVID-19 covid-19 JJ cord-354900-bzv4yhqi 63 15 pandemic pandemic NN cord-354900-bzv4yhqi 63 16 could could MD cord-354900-bzv4yhqi 63 17 disturb disturb VB cord-354900-bzv4yhqi 63 18 our -PRON- PRP$ cord-354900-bzv4yhqi 63 19 immune immune JJ cord-354900-bzv4yhqi 63 20 defences defence NNS cord-354900-bzv4yhqi 63 21 . . . cord-354900-bzv4yhqi 64 1 Shimamiya Shimamiya NNP cord-354900-bzv4yhqi 64 2 et et FW cord-354900-bzv4yhqi 64 3 al al NNP cord-354900-bzv4yhqi 64 4 . . . cord-354900-bzv4yhqi 65 1 showed show VBD cord-354900-bzv4yhqi 65 2 that that IN cord-354900-bzv4yhqi 65 3 the the DT cord-354900-bzv4yhqi 65 4 percentage percentage NN cord-354900-bzv4yhqi 65 5 of of IN cord-354900-bzv4yhqi 65 6 CD69 CD69 NNP cord-354900-bzv4yhqi 65 7 + + CC cord-354900-bzv4yhqi 65 8 lymphocytes lymphocyte NNS cord-354900-bzv4yhqi 65 9 decreased decrease VBD cord-354900-bzv4yhqi 65 10 during during IN cord-354900-bzv4yhqi 65 11 the the DT cord-354900-bzv4yhqi 65 12 confinement confinement NN cord-354900-bzv4yhqi 65 13 period period NN cord-354900-bzv4yhqi 65 14 [ [ -LRB- cord-354900-bzv4yhqi 65 15 45 45 CD cord-354900-bzv4yhqi 65 16 ] ] -RRB- cord-354900-bzv4yhqi 65 17 . . . cord-354900-bzv4yhqi 66 1 This this DT cord-354900-bzv4yhqi 66 2 was be VBD cord-354900-bzv4yhqi 66 3 mostly mostly RB cord-354900-bzv4yhqi 66 4 caused cause VBN cord-354900-bzv4yhqi 66 5 by by IN cord-354900-bzv4yhqi 66 6 changes change NNS cord-354900-bzv4yhqi 66 7 in in IN cord-354900-bzv4yhqi 66 8 the the DT cord-354900-bzv4yhqi 66 9 ratio ratio NN cord-354900-bzv4yhqi 66 10 of of IN cord-354900-bzv4yhqi 66 11 natural natural JJ cord-354900-bzv4yhqi 66 12 killer killer NN cord-354900-bzv4yhqi 66 13 ( ( -LRB- cord-354900-bzv4yhqi 66 14 NK NK NNP cord-354900-bzv4yhqi 66 15 ) ) -RRB- cord-354900-bzv4yhqi 66 16 to to IN cord-354900-bzv4yhqi 66 17 non non JJ cord-354900-bzv4yhqi 66 18 - - JJ cord-354900-bzv4yhqi 66 19 NK nk JJ cord-354900-bzv4yhqi 66 20 lymphocytes lymphocyte NNS cord-354900-bzv4yhqi 66 21 suggesting suggest VBG cord-354900-bzv4yhqi 66 22 that that IN cord-354900-bzv4yhqi 66 23 the the DT cord-354900-bzv4yhqi 66 24 stress stress NN cord-354900-bzv4yhqi 66 25 caused cause VBN cord-354900-bzv4yhqi 66 26 by by IN cord-354900-bzv4yhqi 66 27 confinement confinement NN cord-354900-bzv4yhqi 66 28 plays play VBZ cord-354900-bzv4yhqi 66 29 a a DT cord-354900-bzv4yhqi 66 30 role role NN cord-354900-bzv4yhqi 66 31 in in IN cord-354900-bzv4yhqi 66 32 the the DT cord-354900-bzv4yhqi 66 33 immune immune JJ cord-354900-bzv4yhqi 66 34 changes change NNS cord-354900-bzv4yhqi 66 35 observed observe VBD cord-354900-bzv4yhqi 66 36 [ [ -LRB- cord-354900-bzv4yhqi 66 37 45 45 CD cord-354900-bzv4yhqi 66 38 ] ] -RRB- cord-354900-bzv4yhqi 66 39 . . . cord-354900-bzv4yhqi 67 1 Different different JJ cord-354900-bzv4yhqi 67 2 studies study NNS cord-354900-bzv4yhqi 67 3 have have VBP cord-354900-bzv4yhqi 67 4 shown show VBN cord-354900-bzv4yhqi 67 5 that that IN cord-354900-bzv4yhqi 67 6 β β NN cord-354900-bzv4yhqi 67 7 - - HYPH cord-354900-bzv4yhqi 67 8 glucan glucan NN cord-354900-bzv4yhqi 67 9 has have VBZ cord-354900-bzv4yhqi 67 10 a a DT cord-354900-bzv4yhqi 67 11 significant significant JJ cord-354900-bzv4yhqi 67 12 role role NN cord-354900-bzv4yhqi 67 13 in in IN cord-354900-bzv4yhqi 67 14 stress stress NN cord-354900-bzv4yhqi 67 15 reduction reduction NN cord-354900-bzv4yhqi 67 16 via via IN cord-354900-bzv4yhqi 67 17 the the DT cord-354900-bzv4yhqi 67 18 inhibition inhibition NN cord-354900-bzv4yhqi 67 19 of of IN cord-354900-bzv4yhqi 67 20 corticosterone corticosterone NN cord-354900-bzv4yhqi 67 21 levels level NNS cord-354900-bzv4yhqi 67 22 and and CC cord-354900-bzv4yhqi 67 23 modulation modulation NN cord-354900-bzv4yhqi 67 24 of of IN cord-354900-bzv4yhqi 67 25 cytokine cytokine NN cord-354900-bzv4yhqi 67 26 production production NN cord-354900-bzv4yhqi 67 27 [ [ -LRB- cord-354900-bzv4yhqi 67 28 46 46 CD cord-354900-bzv4yhqi 67 29 , , , cord-354900-bzv4yhqi 67 30 47 47 CD cord-354900-bzv4yhqi 67 31 ] ] -RRB- cord-354900-bzv4yhqi 67 32 . . . cord-354900-bzv4yhqi 68 1 Baker Baker NNP cord-354900-bzv4yhqi 68 2 's 's POS cord-354900-bzv4yhqi 68 3 yeast yeast NN cord-354900-bzv4yhqi 68 4 β β NN cord-354900-bzv4yhqi 68 5 - - HYPH cord-354900-bzv4yhqi 68 6 glucan glucan NN cord-354900-bzv4yhqi 68 7 combined combine VBN cord-354900-bzv4yhqi 68 8 with with IN cord-354900-bzv4yhqi 68 9 a a DT cord-354900-bzv4yhqi 68 10 healthy healthy JJ cord-354900-bzv4yhqi 68 11 diet diet NN cord-354900-bzv4yhqi 68 12 rich rich JJ cord-354900-bzv4yhqi 68 13 in in IN cord-354900-bzv4yhqi 68 14 vitamins vitamin NNS cord-354900-bzv4yhqi 68 15 C c NN cord-354900-bzv4yhqi 68 16 and and CC cord-354900-bzv4yhqi 68 17 D d NN cord-354900-bzv4yhqi 68 18 can can MD cord-354900-bzv4yhqi 68 19 be be VB cord-354900-bzv4yhqi 68 20 used use VBN cord-354900-bzv4yhqi 68 21 to to TO cord-354900-bzv4yhqi 68 22 boost boost VB cord-354900-bzv4yhqi 68 23 the the DT cord-354900-bzv4yhqi 68 24 immune immune JJ cord-354900-bzv4yhqi 68 25 defence defence NN cord-354900-bzv4yhqi 68 26 in in IN cord-354900-bzv4yhqi 68 27 healthy healthy JJ cord-354900-bzv4yhqi 68 28 individuals individual NNS cord-354900-bzv4yhqi 68 29 prior prior RB cord-354900-bzv4yhqi 68 30 to to IN cord-354900-bzv4yhqi 68 31 any any DT cord-354900-bzv4yhqi 68 32 possible possible JJ cord-354900-bzv4yhqi 68 33 viral viral JJ cord-354900-bzv4yhqi 68 34 infection infection NN cord-354900-bzv4yhqi 68 35 . . . cord-354900-bzv4yhqi 69 1 Závorková Závorková NNP cord-354900-bzv4yhqi 69 2 et et NNP cord-354900-bzv4yhqi 69 3 al al NNP cord-354900-bzv4yhqi 69 4 . . NNP cord-354900-bzv4yhqi 69 5 showed show VBD cord-354900-bzv4yhqi 69 6 that that IN cord-354900-bzv4yhqi 69 7 supplementation supplementation NN cord-354900-bzv4yhqi 69 8 with with IN cord-354900-bzv4yhqi 69 9 β β NN cord-354900-bzv4yhqi 69 10 - - HYPH cord-354900-bzv4yhqi 69 11 glucan glucan NN cord-354900-bzv4yhqi 69 12 and and CC cord-354900-bzv4yhqi 69 13 vitamin vitamin NN cord-354900-bzv4yhqi 69 14 D d NN cord-354900-bzv4yhqi 69 15 in in IN cord-354900-bzv4yhqi 69 16 patients patient NNS cord-354900-bzv4yhqi 69 17 with with IN cord-354900-bzv4yhqi 69 18 diabetic diabetic JJ cord-354900-bzv4yhqi 69 19 retinopathy retinopathy NN cord-354900-bzv4yhqi 69 20 resulted result VBD cord-354900-bzv4yhqi 69 21 in in IN cord-354900-bzv4yhqi 69 22 significant significant JJ cord-354900-bzv4yhqi 69 23 improvements improvement NNS cord-354900-bzv4yhqi 69 24 in in IN cord-354900-bzv4yhqi 69 25 high high JJ cord-354900-bzv4yhqi 69 26 - - HYPH cord-354900-bzv4yhqi 69 27 density density NN cord-354900-bzv4yhqi 69 28 lipoprotein lipoprotein NN cord-354900-bzv4yhqi 69 29 levels level NNS cord-354900-bzv4yhqi 69 30 and and CC cord-354900-bzv4yhqi 69 31 a a DT cord-354900-bzv4yhqi 69 32 large large JJ cord-354900-bzv4yhqi 69 33 decrease decrease NN cord-354900-bzv4yhqi 69 34 in in IN cord-354900-bzv4yhqi 69 35 total total JJ cord-354900-bzv4yhqi 69 36 level level NN cord-354900-bzv4yhqi 69 37 of of IN cord-354900-bzv4yhqi 69 38 cholesterol cholesterol NN cord-354900-bzv4yhqi 69 39 , , , cord-354900-bzv4yhqi 69 40 supporting support VBG cord-354900-bzv4yhqi 69 41 the the DT cord-354900-bzv4yhqi 69 42 view view NN cord-354900-bzv4yhqi 69 43 that that IN cord-354900-bzv4yhqi 69 44 β β NN cord-354900-bzv4yhqi 69 45 - - HYPH cord-354900-bzv4yhqi 69 46 glucan glucan NN cord-354900-bzv4yhqi 69 47 and and CC cord-354900-bzv4yhqi 69 48 vitamin vitamin NN cord-354900-bzv4yhqi 69 49 D D NNP cord-354900-bzv4yhqi 69 50 supplementation supplementation NN cord-354900-bzv4yhqi 69 51 has have VBZ cord-354900-bzv4yhqi 69 52 a a DT cord-354900-bzv4yhqi 69 53 positive positive JJ cord-354900-bzv4yhqi 69 54 effect effect NN cord-354900-bzv4yhqi 69 55 on on IN cord-354900-bzv4yhqi 69 56 human human JJ cord-354900-bzv4yhqi 69 57 health health NN cord-354900-bzv4yhqi 69 58 [ [ -LRB- cord-354900-bzv4yhqi 69 59 48 48 CD cord-354900-bzv4yhqi 69 60 ] ] -RRB- cord-354900-bzv4yhqi 69 61 . . . cord-354900-bzv4yhqi 70 1 In in IN cord-354900-bzv4yhqi 70 2 line line NN cord-354900-bzv4yhqi 70 3 with with IN cord-354900-bzv4yhqi 70 4 this this DT cord-354900-bzv4yhqi 70 5 observation observation NN cord-354900-bzv4yhqi 70 6 , , , cord-354900-bzv4yhqi 70 7 β β NN cord-354900-bzv4yhqi 70 8 - - HYPH cord-354900-bzv4yhqi 70 9 glucan glucan NN cord-354900-bzv4yhqi 70 10 can can MD cord-354900-bzv4yhqi 70 11 also also RB cord-354900-bzv4yhqi 70 12 increase increase VB cord-354900-bzv4yhqi 70 13 the the DT cord-354900-bzv4yhqi 70 14 effects effect NNS cord-354900-bzv4yhqi 70 15 of of IN cord-354900-bzv4yhqi 70 16 vitamin vitamin NN cord-354900-bzv4yhqi 70 17 D d NN cord-354900-bzv4yhqi 70 18 with with IN cord-354900-bzv4yhqi 70 19 positive positive JJ cord-354900-bzv4yhqi 70 20 changes change NNS cord-354900-bzv4yhqi 70 21 in in IN cord-354900-bzv4yhqi 70 22 apolipoprotein apolipoprotein NN cord-354900-bzv4yhqi 70 23 A1 A1 NNP cord-354900-bzv4yhqi 70 24 metabolism metabolism NN cord-354900-bzv4yhqi 70 25 in in IN cord-354900-bzv4yhqi 70 26 patients patient NNS cord-354900-bzv4yhqi 70 27 with with IN cord-354900-bzv4yhqi 70 28 diabetic diabetic JJ cord-354900-bzv4yhqi 70 29 retinopathy retinopathy NN cord-354900-bzv4yhqi 70 30 [ [ -LRB- cord-354900-bzv4yhqi 70 31 49 49 CD cord-354900-bzv4yhqi 70 32 ] ] -RRB- cord-354900-bzv4yhqi 70 33 . . . cord-354900-bzv4yhqi 71 1 Additionally additionally RB cord-354900-bzv4yhqi 71 2 , , , cord-354900-bzv4yhqi 71 3 several several JJ cord-354900-bzv4yhqi 71 4 studies study NNS cord-354900-bzv4yhqi 71 5 have have VBP cord-354900-bzv4yhqi 71 6 demonstrated demonstrate VBN cord-354900-bzv4yhqi 71 7 beneficial beneficial JJ cord-354900-bzv4yhqi 71 8 effects effect NNS cord-354900-bzv4yhqi 71 9 when when WRB cord-354900-bzv4yhqi 71 10 β β NN cord-354900-bzv4yhqi 71 11 - - HYPH cord-354900-bzv4yhqi 71 12 glucan glucan NNP cord-354900-bzv4yhqi 71 13 was be VBD cord-354900-bzv4yhqi 71 14 given give VBN cord-354900-bzv4yhqi 71 15 in in IN cord-354900-bzv4yhqi 71 16 combination combination NN cord-354900-bzv4yhqi 71 17 with with IN cord-354900-bzv4yhqi 71 18 vitamin vitamin NN cord-354900-bzv4yhqi 71 19 C c NN cord-354900-bzv4yhqi 71 20 [ [ -LRB- cord-354900-bzv4yhqi 71 21 47 47 CD cord-354900-bzv4yhqi 71 22 , , , cord-354900-bzv4yhqi 71 23 50 50 CD cord-354900-bzv4yhqi 71 24 , , , cord-354900-bzv4yhqi 71 25 51 51 CD cord-354900-bzv4yhqi 71 26 ] ] -RRB- cord-354900-bzv4yhqi 71 27 . . . cord-354900-bzv4yhqi 72 1 An an DT cord-354900-bzv4yhqi 72 2 experimental experimental JJ cord-354900-bzv4yhqi 72 3 study study NN cord-354900-bzv4yhqi 72 4 revealed reveal VBD cord-354900-bzv4yhqi 72 5 that that IN cord-354900-bzv4yhqi 72 6 combination combination NN cord-354900-bzv4yhqi 72 7 of of IN cord-354900-bzv4yhqi 72 8 glucan glucan NN cord-354900-bzv4yhqi 72 9 - - HYPH cord-354900-bzv4yhqi 72 10 vitamin vitamin NN cord-354900-bzv4yhqi 72 11 C C NNP cord-354900-bzv4yhqi 72 12 showed show VBD cord-354900-bzv4yhqi 72 13 notable notable JJ cord-354900-bzv4yhqi 72 14 healing healing NN cord-354900-bzv4yhqi 72 15 abilities ability NNS cord-354900-bzv4yhqi 72 16 in in IN cord-354900-bzv4yhqi 72 17 the the DT cord-354900-bzv4yhqi 72 18 treatment treatment NN cord-354900-bzv4yhqi 72 19 of of IN cord-354900-bzv4yhqi 72 20 infection infection NN cord-354900-bzv4yhqi 72 21 by by IN cord-354900-bzv4yhqi 72 22 Mesocestoides Mesocestoides NNP cord-354900-bzv4yhqi 72 23 corti corti NNP cord-354900-bzv4yhqi 72 24 [ [ -LRB- cord-354900-bzv4yhqi 72 25 50 50 CD cord-354900-bzv4yhqi 72 26 ] ] -RRB- cord-354900-bzv4yhqi 72 27 . . . cord-354900-bzv4yhqi 73 1 Konno Konno NNP cord-354900-bzv4yhqi 73 2 et et NNP cord-354900-bzv4yhqi 73 3 al al NNP cord-354900-bzv4yhqi 73 4 . . NNP cord-354900-bzv4yhqi 73 5 pointed point VBD cord-354900-bzv4yhqi 73 6 out out RP cord-354900-bzv4yhqi 73 7 that that IN cord-354900-bzv4yhqi 73 8 synergistic synergistic JJ cord-354900-bzv4yhqi 73 9 potentiation potentiation NN cord-354900-bzv4yhqi 73 10 of of IN cord-354900-bzv4yhqi 73 11 β β NN cord-354900-bzv4yhqi 73 12 - - HYPH cord-354900-bzv4yhqi 73 13 glucan glucan NN cord-354900-bzv4yhqi 73 14 with with IN cord-354900-bzv4yhqi 73 15 vitamin vitamin NN cord-354900-bzv4yhqi 73 16 C C NNP cord-354900-bzv4yhqi 73 17 may may MD cord-354900-bzv4yhqi 73 18 improve improve VB cord-354900-bzv4yhqi 73 19 the the DT cord-354900-bzv4yhqi 73 20 efficacy efficacy NN cord-354900-bzv4yhqi 73 21 of of IN cord-354900-bzv4yhqi 73 22 current current JJ cord-354900-bzv4yhqi 73 23 treatments treatment NNS cord-354900-bzv4yhqi 73 24 for for IN cord-354900-bzv4yhqi 73 25 various various JJ cord-354900-bzv4yhqi 73 26 human human JJ cord-354900-bzv4yhqi 73 27 cancers cancer NNS cord-354900-bzv4yhqi 73 28 [ [ -LRB- cord-354900-bzv4yhqi 73 29 52 52 CD cord-354900-bzv4yhqi 73 30 ] ] -RRB- cord-354900-bzv4yhqi 73 31 . . . cord-354900-bzv4yhqi 74 1 Vitamins Vitamins NNP cord-354900-bzv4yhqi 74 2 C c NN cord-354900-bzv4yhqi 74 3 and and CC cord-354900-bzv4yhqi 74 4 D D NNP cord-354900-bzv4yhqi 74 5 are be VBP cord-354900-bzv4yhqi 74 6 well well RB cord-354900-bzv4yhqi 74 7 - - HYPH cord-354900-bzv4yhqi 74 8 known know VBN cord-354900-bzv4yhqi 74 9 to to TO cord-354900-bzv4yhqi 74 10 boost boost VB cord-354900-bzv4yhqi 74 11 the the DT cord-354900-bzv4yhqi 74 12 immune immune JJ cord-354900-bzv4yhqi 74 13 response response NN cord-354900-bzv4yhqi 74 14 against against IN cord-354900-bzv4yhqi 74 15 viral viral JJ cord-354900-bzv4yhqi 74 16 infections infection NNS cord-354900-bzv4yhqi 74 17 [ [ -LRB- cord-354900-bzv4yhqi 74 18 53 53 CD cord-354900-bzv4yhqi 74 19 ] ] -RRB- cord-354900-bzv4yhqi 75 1 [ [ -LRB- cord-354900-bzv4yhqi 75 2 54 54 CD cord-354900-bzv4yhqi 75 3 ] ] -RRB- cord-354900-bzv4yhqi 76 1 [ [ -LRB- cord-354900-bzv4yhqi 76 2 55 55 CD cord-354900-bzv4yhqi 76 3 ] ] -RRB- cord-354900-bzv4yhqi 76 4 [ [ -LRB- cord-354900-bzv4yhqi 76 5 56 56 CD cord-354900-bzv4yhqi 76 6 ] ] -RRB- cord-354900-bzv4yhqi 76 7 [ [ -LRB- cord-354900-bzv4yhqi 76 8 57 57 CD cord-354900-bzv4yhqi 76 9 ] ] -RRB- cord-354900-bzv4yhqi 77 1 ( ( -LRB- cord-354900-bzv4yhqi 77 2 Fig Fig NNP cord-354900-bzv4yhqi 77 3 . . NNP cord-354900-bzv4yhqi 77 4 1 1 CD cord-354900-bzv4yhqi 77 5 ) ) -RRB- cord-354900-bzv4yhqi 77 6 . . . cord-354900-bzv4yhqi 78 1 These these DT cord-354900-bzv4yhqi 78 2 vitamins vitamin NNS cord-354900-bzv4yhqi 78 3 have have VBP cord-354900-bzv4yhqi 78 4 both both DT cord-354900-bzv4yhqi 78 5 been be VBN cord-354900-bzv4yhqi 78 6 implicated implicate VBN cord-354900-bzv4yhqi 78 7 in in IN cord-354900-bzv4yhqi 78 8 the the DT cord-354900-bzv4yhqi 78 9 immune immune JJ cord-354900-bzv4yhqi 78 10 response response NN cord-354900-bzv4yhqi 78 11 to to IN cord-354900-bzv4yhqi 78 12 several several JJ cord-354900-bzv4yhqi 78 13 types type NNS cord-354900-bzv4yhqi 78 14 of of IN cord-354900-bzv4yhqi 78 15 respiratory respiratory JJ cord-354900-bzv4yhqi 78 16 infections infection NNS cord-354900-bzv4yhqi 78 17 , , , cord-354900-bzv4yhqi 78 18 including include VBG cord-354900-bzv4yhqi 78 19 influenza influenza NN cord-354900-bzv4yhqi 78 20 , , , cord-354900-bzv4yhqi 78 21 respiratory respiratory JJ cord-354900-bzv4yhqi 78 22 syncytial syncytial JJ cord-354900-bzv4yhqi 78 23 virus virus NN cord-354900-bzv4yhqi 78 24 and and CC cord-354900-bzv4yhqi 78 25 tuberculosis tuberculosis NN cord-354900-bzv4yhqi 78 26 [ [ -LRB- cord-354900-bzv4yhqi 78 27 53 53 CD cord-354900-bzv4yhqi 78 28 ] ] -RRB- cord-354900-bzv4yhqi 79 1 [ [ -LRB- cord-354900-bzv4yhqi 79 2 54 54 CD cord-354900-bzv4yhqi 79 3 ] ] -RRB- cord-354900-bzv4yhqi 80 1 [ [ -LRB- cord-354900-bzv4yhqi 80 2 55 55 CD cord-354900-bzv4yhqi 80 3 ] ] -RRB- cord-354900-bzv4yhqi 80 4 [ [ -LRB- cord-354900-bzv4yhqi 80 5 56 56 CD cord-354900-bzv4yhqi 80 6 ] ] -RRB- cord-354900-bzv4yhqi 80 7 [ [ -LRB- cord-354900-bzv4yhqi 80 8 57 57 CD cord-354900-bzv4yhqi 80 9 ] ] -RRB- cord-354900-bzv4yhqi 80 10 . . . cord-354900-bzv4yhqi 81 1 Hansdottir Hansdottir NNP cord-354900-bzv4yhqi 81 2 et et NNP cord-354900-bzv4yhqi 81 3 al al NNP cord-354900-bzv4yhqi 81 4 . . NNP cord-354900-bzv4yhqi 81 5 showed show VBD cord-354900-bzv4yhqi 81 6 that that IN cord-354900-bzv4yhqi 81 7 vitamin vitamin NN cord-354900-bzv4yhqi 81 8 D d NN cord-354900-bzv4yhqi 81 9 reduces reduce VBZ cord-354900-bzv4yhqi 81 10 the the DT cord-354900-bzv4yhqi 81 11 inflammatory inflammatory JJ cord-354900-bzv4yhqi 81 12 response response NN cord-354900-bzv4yhqi 81 13 to to IN cord-354900-bzv4yhqi 81 14 respiratory respiratory JJ cord-354900-bzv4yhqi 81 15 syncytial syncytial JJ cord-354900-bzv4yhqi 81 16 virus virus NN cord-354900-bzv4yhqi 81 17 via via IN cord-354900-bzv4yhqi 81 18 decreasing decrease VBG cord-354900-bzv4yhqi 81 19 the the DT cord-354900-bzv4yhqi 81 20 production production NN cord-354900-bzv4yhqi 81 21 of of IN cord-354900-bzv4yhqi 81 22 cytokines cytokine NNS cord-354900-bzv4yhqi 81 23 and and CC cord-354900-bzv4yhqi 81 24 chemokines chemokine NNS cord-354900-bzv4yhqi 81 25 in in IN cord-354900-bzv4yhqi 81 26 the the DT cord-354900-bzv4yhqi 81 27 airways airways NNP cord-354900-bzv4yhqi 81 28 epithelium epithelium NN cord-354900-bzv4yhqi 81 29 while while IN cord-354900-bzv4yhqi 81 30 maintaining maintain VBG cord-354900-bzv4yhqi 81 31 the the DT cord-354900-bzv4yhqi 81 32 antiviral antiviral JJ cord-354900-bzv4yhqi 81 33 state state NN cord-354900-bzv4yhqi 81 34 [ [ -LRB- cord-354900-bzv4yhqi 81 35 55 55 CD cord-354900-bzv4yhqi 81 36 ] ] -RRB- cord-354900-bzv4yhqi 81 37 . . . cord-354900-bzv4yhqi 82 1 In in IN cord-354900-bzv4yhqi 82 2 addition addition NN cord-354900-bzv4yhqi 82 3 to to IN cord-354900-bzv4yhqi 82 4 vitamins vitamin NNS cord-354900-bzv4yhqi 82 5 C c NN cord-354900-bzv4yhqi 82 6 and and CC cord-354900-bzv4yhqi 82 7 D D NNP cord-354900-bzv4yhqi 82 8 , , , cord-354900-bzv4yhqi 82 9 vitamins vitamin NNS cord-354900-bzv4yhqi 82 10 B b NN cord-354900-bzv4yhqi 82 11 , , , cord-354900-bzv4yhqi 82 12 E e NN cord-354900-bzv4yhqi 82 13 , , , cord-354900-bzv4yhqi 82 14 omega-3 omega-3 JJ cord-354900-bzv4yhqi 82 15 fatty fatty JJ cord-354900-bzv4yhqi 82 16 acids acid NNS cord-354900-bzv4yhqi 82 17 , , , cord-354900-bzv4yhqi 82 18 carotenoids carotenoid NNS cord-354900-bzv4yhqi 82 19 , , , cord-354900-bzv4yhqi 82 20 polyphenols polyphenol NNS cord-354900-bzv4yhqi 82 21 ( ( -LRB- cord-354900-bzv4yhqi 82 22 flavonoids flavonoid NNS cord-354900-bzv4yhqi 82 23 , , , cord-354900-bzv4yhqi 82 24 phenolic phenolic JJ cord-354900-bzv4yhqi 82 25 acids acid NNS cord-354900-bzv4yhqi 82 26 ) ) -RRB- cord-354900-bzv4yhqi 82 27 , , , cord-354900-bzv4yhqi 82 28 and and CC cord-354900-bzv4yhqi 82 29 some some DT cord-354900-bzv4yhqi 82 30 minerals mineral NNS cord-354900-bzv4yhqi 82 31 ( ( -LRB- cord-354900-bzv4yhqi 82 32 Zn Zn NNP cord-354900-bzv4yhqi 82 33 , , , cord-354900-bzv4yhqi 82 34 Mn Mn NNP cord-354900-bzv4yhqi 82 35 , , , cord-354900-bzv4yhqi 82 36 Cu Cu NNP cord-354900-bzv4yhqi 82 37 , , , cord-354900-bzv4yhqi 82 38 Se Se NNP cord-354900-bzv4yhqi 82 39 ) ) -RRB- cord-354900-bzv4yhqi 82 40 can can MD cord-354900-bzv4yhqi 82 41 provide provide VB cord-354900-bzv4yhqi 82 42 health health NN cord-354900-bzv4yhqi 82 43 benefits benefit NNS cord-354900-bzv4yhqi 82 44 by by IN cord-354900-bzv4yhqi 82 45 a a DT cord-354900-bzv4yhqi 82 46 synergistic synergistic JJ cord-354900-bzv4yhqi 82 47 effect effect NN cord-354900-bzv4yhqi 82 48 , , , cord-354900-bzv4yhqi 82 49 maintaining maintain VBG cord-354900-bzv4yhqi 82 50 a a DT cord-354900-bzv4yhqi 82 51 proper proper JJ cord-354900-bzv4yhqi 82 52 redox redox NN cord-354900-bzv4yhqi 82 53 homeostasis homeostasis NN cord-354900-bzv4yhqi 82 54 [ [ -LRB- cord-354900-bzv4yhqi 82 55 58 58 CD cord-354900-bzv4yhqi 82 56 ] ] -RRB- cord-354900-bzv4yhqi 82 57 [ [ -LRB- cord-354900-bzv4yhqi 82 58 59 59 CD cord-354900-bzv4yhqi 82 59 ] ] -RRB- cord-354900-bzv4yhqi 82 60 [ [ -LRB- cord-354900-bzv4yhqi 82 61 60 60 CD cord-354900-bzv4yhqi 82 62 ] ] -RRB- cord-354900-bzv4yhqi 82 63 . . . cord-354900-bzv4yhqi 83 1 In in IN cord-354900-bzv4yhqi 83 2 terms term NNS cord-354900-bzv4yhqi 83 3 of of IN cord-354900-bzv4yhqi 83 4 SARS SARS NNP cord-354900-bzv4yhqi 83 5 - - HYPH cord-354900-bzv4yhqi 83 6 CoV-2 CoV-2 NNP cord-354900-bzv4yhqi 83 7 , , , cord-354900-bzv4yhqi 83 8 vitamin vitamin NN cord-354900-bzv4yhqi 83 9 D d NN cord-354900-bzv4yhqi 83 10 was be VBD cord-354900-bzv4yhqi 83 11 employed employ VBN cord-354900-bzv4yhqi 83 12 in in IN cord-354900-bzv4yhqi 83 13 the the DT cord-354900-bzv4yhqi 83 14 early early JJ cord-354900-bzv4yhqi 83 15 nutritional nutritional JJ cord-354900-bzv4yhqi 83 16 supplementation supplementation NN cord-354900-bzv4yhqi 83 17 of of IN cord-354900-bzv4yhqi 83 18 non non JJ cord-354900-bzv4yhqi 83 19 - - JJ cord-354900-bzv4yhqi 83 20 critically critically RB cord-354900-bzv4yhqi 83 21 ill ill JJ cord-354900-bzv4yhqi 83 22 patients patient NNS cord-354900-bzv4yhqi 83 23 hospitalized hospitalize VBN cord-354900-bzv4yhqi 83 24 for for IN cord-354900-bzv4yhqi 83 25 COVID-19 COVID-19 NNP cord-354900-bzv4yhqi 83 26 disease disease NN cord-354900-bzv4yhqi 83 27 [ [ -LRB- cord-354900-bzv4yhqi 83 28 61 61 CD cord-354900-bzv4yhqi 83 29 ] ] -RRB- cord-354900-bzv4yhqi 83 30 . . . cord-354900-bzv4yhqi 84 1 Additionally additionally RB cord-354900-bzv4yhqi 84 2 , , , cord-354900-bzv4yhqi 84 3 vitamin vitamin NN cord-354900-bzv4yhqi 84 4 D d NN cord-354900-bzv4yhqi 84 5 can can MD cord-354900-bzv4yhqi 84 6 modulate modulate VB cord-354900-bzv4yhqi 84 7 the the DT cord-354900-bzv4yhqi 84 8 immune immune JJ cord-354900-bzv4yhqi 84 9 response response NN cord-354900-bzv4yhqi 84 10 by by IN cord-354900-bzv4yhqi 84 11 reducing reduce VBG cord-354900-bzv4yhqi 84 12 the the DT cord-354900-bzv4yhqi 84 13 cytokine cytokine NN cord-354900-bzv4yhqi 84 14 storm storm NN cord-354900-bzv4yhqi 84 15 induced induce VBN cord-354900-bzv4yhqi 84 16 by by IN cord-354900-bzv4yhqi 84 17 the the DT cord-354900-bzv4yhqi 84 18 innate innate JJ cord-354900-bzv4yhqi 84 19 immune immune JJ cord-354900-bzv4yhqi 84 20 system system NN cord-354900-bzv4yhqi 84 21 , , , cord-354900-bzv4yhqi 84 22 such such JJ cord-354900-bzv4yhqi 84 23 as as IN cord-354900-bzv4yhqi 84 24 tumour tumour NN cord-354900-bzv4yhqi 84 25 - - HYPH cord-354900-bzv4yhqi 84 26 necrosis necrosis NN cord-354900-bzv4yhqi 84 27 factor factor NN cord-354900-bzv4yhqi 84 28 ( ( -LRB- cord-354900-bzv4yhqi 84 29 TNF)-α TNF)-α NNP cord-354900-bzv4yhqi 84 30 and and CC cord-354900-bzv4yhqi 84 31 IFN IFN NNP cord-354900-bzv4yhqi 84 32 - - HYPH cord-354900-bzv4yhqi 84 33 γ γ NNP cord-354900-bzv4yhqi 84 34 [ [ -LRB- cord-354900-bzv4yhqi 84 35 62 62 CD cord-354900-bzv4yhqi 84 36 ] ] -RRB- cord-354900-bzv4yhqi 84 37 . . . cord-354900-bzv4yhqi 85 1 Further further JJ cord-354900-bzv4yhqi 85 2 investigations investigation NNS cord-354900-bzv4yhqi 85 3 demonstrated demonstrate VBD cord-354900-bzv4yhqi 85 4 that that IN cord-354900-bzv4yhqi 85 5 elevated elevated JJ cord-354900-bzv4yhqi 85 6 vitamin vitamin NN cord-354900-bzv4yhqi 85 7 D d NN cord-354900-bzv4yhqi 85 8 levels level NNS cord-354900-bzv4yhqi 85 9 in in IN cord-354900-bzv4yhqi 85 10 healthy healthy JJ cord-354900-bzv4yhqi 85 11 individuals individual NNS cord-354900-bzv4yhqi 85 12 are be VBP cord-354900-bzv4yhqi 85 13 associated associate VBN cord-354900-bzv4yhqi 85 14 with with IN cord-354900-bzv4yhqi 85 15 down down JJ cord-354900-bzv4yhqi 85 16 - - HYPH cord-354900-bzv4yhqi 85 17 regulation regulation NN cord-354900-bzv4yhqi 85 18 of of IN cord-354900-bzv4yhqi 85 19 pro pro JJ cord-354900-bzv4yhqi 85 20 - - JJ cord-354900-bzv4yhqi 85 21 inflammatory inflammatory JJ cord-354900-bzv4yhqi 85 22 cytokine cytokine NN cord-354900-bzv4yhqi 85 23 production production NN cord-354900-bzv4yhqi 85 24 through through IN cord-354900-bzv4yhqi 85 25 decreased decrease VBN cord-354900-bzv4yhqi 85 26 expression expression NN cord-354900-bzv4yhqi 85 27 of of IN cord-354900-bzv4yhqi 85 28 TLR4 TLR4 NNP cord-354900-bzv4yhqi 85 29 [ [ -LRB- cord-354900-bzv4yhqi 85 30 63 63 CD cord-354900-bzv4yhqi 85 31 ] ] -RRB- cord-354900-bzv4yhqi 85 32 . . . cord-354900-bzv4yhqi 86 1 Grant Grant NNP cord-354900-bzv4yhqi 86 2 et et NNP cord-354900-bzv4yhqi 86 3 al al NNP cord-354900-bzv4yhqi 86 4 . . NNP cord-354900-bzv4yhqi 86 5 showed show VBD cord-354900-bzv4yhqi 86 6 that that IN cord-354900-bzv4yhqi 86 7 vitamin vitamin NN cord-354900-bzv4yhqi 86 8 D d NN cord-354900-bzv4yhqi 86 9 supplementation supplementation NN cord-354900-bzv4yhqi 86 10 could could MD cord-354900-bzv4yhqi 86 11 reduce reduce VB cord-354900-bzv4yhqi 86 12 the the DT cord-354900-bzv4yhqi 86 13 incidence incidence NN cord-354900-bzv4yhqi 86 14 , , , cord-354900-bzv4yhqi 86 15 severity severity NN cord-354900-bzv4yhqi 86 16 and and CC cord-354900-bzv4yhqi 86 17 risk risk NN cord-354900-bzv4yhqi 86 18 of of IN cord-354900-bzv4yhqi 86 19 death death NN cord-354900-bzv4yhqi 86 20 from from IN cord-354900-bzv4yhqi 86 21 COVID-19 COVID-19 NNP cord-354900-bzv4yhqi 86 22 [ [ -LRB- cord-354900-bzv4yhqi 86 23 64 64 CD cord-354900-bzv4yhqi 86 24 ] ] -RRB- cord-354900-bzv4yhqi 86 25 . . . cord-354900-bzv4yhqi 87 1 Recently recently RB cord-354900-bzv4yhqi 87 2 , , , cord-354900-bzv4yhqi 87 3 Munshi Munshi NNP cord-354900-bzv4yhqi 87 4 et et NNP cord-354900-bzv4yhqi 87 5 al al NNP cord-354900-bzv4yhqi 87 6 . . NNP cord-354900-bzv4yhqi 87 7 showed show VBD cord-354900-bzv4yhqi 87 8 an an DT cord-354900-bzv4yhqi 87 9 association association NN cord-354900-bzv4yhqi 87 10 of of IN cord-354900-bzv4yhqi 87 11 vitamin vitamin NN cord-354900-bzv4yhqi 87 12 D D NNP cord-354900-bzv4yhqi 87 13 serum serum NN cord-354900-bzv4yhqi 87 14 levels level NNS cord-354900-bzv4yhqi 87 15 with with IN cord-354900-bzv4yhqi 87 16 COVID-19 covid-19 JJ cord-354900-bzv4yhqi 87 17 severity severity NN cord-354900-bzv4yhqi 87 18 and and CC cord-354900-bzv4yhqi 87 19 prognosis prognosis NN cord-354900-bzv4yhqi 87 20 [ [ -LRB- cord-354900-bzv4yhqi 87 21 65 65 CD cord-354900-bzv4yhqi 87 22 ] ] -RRB- cord-354900-bzv4yhqi 87 23 . . . cord-354900-bzv4yhqi 88 1 Patients patient NNS cord-354900-bzv4yhqi 88 2 with with IN cord-354900-bzv4yhqi 88 3 poor poor JJ cord-354900-bzv4yhqi 88 4 prognosis prognosis NN cord-354900-bzv4yhqi 88 5 had have VBD cord-354900-bzv4yhqi 88 6 significantly significantly RB cord-354900-bzv4yhqi 88 7 lower low JJR cord-354900-bzv4yhqi 88 8 serum serum NN cord-354900-bzv4yhqi 88 9 levels level NNS cord-354900-bzv4yhqi 88 10 of of IN cord-354900-bzv4yhqi 88 11 vitamin vitamin NN cord-354900-bzv4yhqi 88 12 D d NN cord-354900-bzv4yhqi 88 13 compared compare VBN cord-354900-bzv4yhqi 88 14 to to IN cord-354900-bzv4yhqi 88 15 those those DT cord-354900-bzv4yhqi 88 16 with with IN cord-354900-bzv4yhqi 88 17 good good JJ cord-354900-bzv4yhqi 88 18 prognosis prognosis NN cord-354900-bzv4yhqi 88 19 supporting support VBG cord-354900-bzv4yhqi 88 20 that that IN cord-354900-bzv4yhqi 88 21 serum serum NN cord-354900-bzv4yhqi 88 22 vitamin vitamin NN cord-354900-bzv4yhqi 88 23 D d NN cord-354900-bzv4yhqi 88 24 levels level NNS cord-354900-bzv4yhqi 88 25 could could MD cord-354900-bzv4yhqi 88 26 be be VB cord-354900-bzv4yhqi 88 27 implicated implicate VBN cord-354900-bzv4yhqi 88 28 in in IN cord-354900-bzv4yhqi 88 29 the the DT cord-354900-bzv4yhqi 88 30 COVID-19 covid-19 JJ cord-354900-bzv4yhqi 88 31 prognosis prognosis NN cord-354900-bzv4yhqi 88 32 and and CC cord-354900-bzv4yhqi 88 33 diagnosis diagnosis NN cord-354900-bzv4yhqi 88 34 of of IN cord-354900-bzv4yhqi 88 35 vitamin vitamin NN cord-354900-bzv4yhqi 88 36 D D NNP cord-354900-bzv4yhqi 88 37 deficiency deficiency NN cord-354900-bzv4yhqi 88 38 could could MD cord-354900-bzv4yhqi 88 39 be be VB cord-354900-bzv4yhqi 88 40 a a DT cord-354900-bzv4yhqi 88 41 helpful helpful JJ cord-354900-bzv4yhqi 88 42 adjunct adjunct NN cord-354900-bzv4yhqi 88 43 in in IN cord-354900-bzv4yhqi 88 44 assessing assess VBG cord-354900-bzv4yhqi 88 45 patients patient NNS cord-354900-bzv4yhqi 88 46 ' ' POS cord-354900-bzv4yhqi 88 47 potential potential NN cord-354900-bzv4yhqi 88 48 of of IN cord-354900-bzv4yhqi 88 49 developing develop VBG cord-354900-bzv4yhqi 88 50 severe severe JJ cord-354900-bzv4yhqi 88 51 COVID-19 COVID-19 NNP cord-354900-bzv4yhqi 88 52 [ [ -LRB- cord-354900-bzv4yhqi 88 53 65 65 CD cord-354900-bzv4yhqi 88 54 ] ] -RRB- cord-354900-bzv4yhqi 88 55 . . . cord-354900-bzv4yhqi 89 1 In in IN cord-354900-bzv4yhqi 89 2 addition addition NN cord-354900-bzv4yhqi 89 3 to to IN cord-354900-bzv4yhqi 89 4 vitamin vitamin NN cord-354900-bzv4yhqi 89 5 D d NN cord-354900-bzv4yhqi 89 6 , , , cord-354900-bzv4yhqi 89 7 vitamin vitamin NN cord-354900-bzv4yhqi 89 8 C C NNP cord-354900-bzv4yhqi 89 9 has have VBZ cord-354900-bzv4yhqi 89 10 been be VBN cord-354900-bzv4yhqi 89 11 proposed propose VBN cord-354900-bzv4yhqi 89 12 to to TO cord-354900-bzv4yhqi 89 13 prevent prevent VB cord-354900-bzv4yhqi 89 14 and and CC cord-354900-bzv4yhqi 89 15 treat treat VB cord-354900-bzv4yhqi 89 16 COVID-19 COVID-19 NNP cord-354900-bzv4yhqi 89 17 [ [ -LRB- cord-354900-bzv4yhqi 89 18 66 66 CD cord-354900-bzv4yhqi 89 19 ] ] -RRB- cord-354900-bzv4yhqi 89 20 . . . cord-354900-bzv4yhqi 90 1 A a DT cord-354900-bzv4yhqi 90 2 new new JJ cord-354900-bzv4yhqi 90 3 clinical clinical JJ cord-354900-bzv4yhqi 90 4 trial trial NN cord-354900-bzv4yhqi 90 5 has have VBZ cord-354900-bzv4yhqi 90 6 begun begin VBN cord-354900-bzv4yhqi 90 7 in in IN cord-354900-bzv4yhqi 90 8 Wuhan Wuhan NNP cord-354900-bzv4yhqi 90 9 , , , cord-354900-bzv4yhqi 90 10 China China NNP cord-354900-bzv4yhqi 90 11 , , , cord-354900-bzv4yhqi 90 12 to to TO cord-354900-bzv4yhqi 90 13 investigate investigate VB cord-354900-bzv4yhqi 90 14 the the DT cord-354900-bzv4yhqi 90 15 role role NN cord-354900-bzv4yhqi 90 16 of of IN cord-354900-bzv4yhqi 90 17 vitamin vitamin NN cord-354900-bzv4yhqi 90 18 C c NN cord-354900-bzv4yhqi 90 19 infusion infusion NN cord-354900-bzv4yhqi 90 20 in in IN cord-354900-bzv4yhqi 90 21 the the DT cord-354900-bzv4yhqi 90 22 treatment treatment NN cord-354900-bzv4yhqi 90 23 of of IN cord-354900-bzv4yhqi 90 24 severe severe JJ cord-354900-bzv4yhqi 90 25 SARS SARS NNP cord-354900-bzv4yhqi 90 26 - - HYPH cord-354900-bzv4yhqi 90 27 CoV-2 CoV-2 NNP cord-354900-bzv4yhqi 90 28 pneumonia pneumonia NN cord-354900-bzv4yhqi 90 29 [ [ -LRB- cord-354900-bzv4yhqi 90 30 66 66 CD cord-354900-bzv4yhqi 90 31 ] ] -RRB- cord-354900-bzv4yhqi 90 32 . . . cord-354900-bzv4yhqi 91 1 Vitamin vitamin NN cord-354900-bzv4yhqi 91 2 D d NN cord-354900-bzv4yhqi 91 3 also also RB cord-354900-bzv4yhqi 91 4 plays play VBZ cord-354900-bzv4yhqi 91 5 an an DT cord-354900-bzv4yhqi 91 6 important important JJ cord-354900-bzv4yhqi 91 7 role role NN cord-354900-bzv4yhqi 91 8 in in IN cord-354900-bzv4yhqi 91 9 the the DT cord-354900-bzv4yhqi 91 10 gut gut NN cord-354900-bzv4yhqi 91 11 by by IN cord-354900-bzv4yhqi 91 12 reinforcing reinforce VBG cord-354900-bzv4yhqi 91 13 the the DT cord-354900-bzv4yhqi 91 14 integrity integrity NN cord-354900-bzv4yhqi 91 15 of of IN cord-354900-bzv4yhqi 91 16 the the DT cord-354900-bzv4yhqi 91 17 intestinal intestinal JJ cord-354900-bzv4yhqi 91 18 barrier barrier NN cord-354900-bzv4yhqi 91 19 and and CC cord-354900-bzv4yhqi 91 20 enhancing enhance VBG cord-354900-bzv4yhqi 91 21 the the DT cord-354900-bzv4yhqi 91 22 tight tight JJ cord-354900-bzv4yhqi 91 23 junctions junction NNS cord-354900-bzv4yhqi 91 24 that that WDT cord-354900-bzv4yhqi 91 25 control control VBP cord-354900-bzv4yhqi 91 26 mucosal mucosal JJ cord-354900-bzv4yhqi 91 27 permeability permeability NN cord-354900-bzv4yhqi 91 28 [ [ -LRB- cord-354900-bzv4yhqi 91 29 67 67 CD cord-354900-bzv4yhqi 91 30 ] ] -RRB- cord-354900-bzv4yhqi 91 31 . . . cord-354900-bzv4yhqi 92 1 The the DT cord-354900-bzv4yhqi 92 2 gut gut NN cord-354900-bzv4yhqi 92 3 microbiota microbiota NN cord-354900-bzv4yhqi 92 4 can can MD cord-354900-bzv4yhqi 92 5 also also RB cord-354900-bzv4yhqi 92 6 be be VB cord-354900-bzv4yhqi 92 7 disrupted disrupt VBN cord-354900-bzv4yhqi 92 8 by by IN cord-354900-bzv4yhqi 92 9 stress stress NN cord-354900-bzv4yhqi 92 10 and and CC cord-354900-bzv4yhqi 92 11 poor poor JJ cord-354900-bzv4yhqi 92 12 nutrition nutrition NN cord-354900-bzv4yhqi 92 13 during during IN cord-354900-bzv4yhqi 92 14 the the DT cord-354900-bzv4yhqi 92 15 COVID-19 COVID-19 NNP cord-354900-bzv4yhqi 92 16 lockdown lockdown NN cord-354900-bzv4yhqi 92 17 . . . cord-354900-bzv4yhqi 93 1 Microbiota Microbiota NNP cord-354900-bzv4yhqi 93 2 diversity diversity NN cord-354900-bzv4yhqi 93 3 is be VBZ cord-354900-bzv4yhqi 93 4 crucial crucial JJ cord-354900-bzv4yhqi 93 5 to to TO cord-354900-bzv4yhqi 93 6 maintain maintain VB cord-354900-bzv4yhqi 93 7 barrier barrier NN cord-354900-bzv4yhqi 93 8 defences defence NNS cord-354900-bzv4yhqi 93 9 , , , cord-354900-bzv4yhqi 93 10 gut gut NN cord-354900-bzv4yhqi 93 11 homeostasis homeostasis NN cord-354900-bzv4yhqi 93 12 and and CC cord-354900-bzv4yhqi 93 13 to to TO cord-354900-bzv4yhqi 93 14 resist resist VB cord-354900-bzv4yhqi 93 15 stress stress NN cord-354900-bzv4yhqi 93 16 , , , cord-354900-bzv4yhqi 93 17 gut gut NN cord-354900-bzv4yhqi 93 18 infections infection NNS cord-354900-bzv4yhqi 93 19 or or CC cord-354900-bzv4yhqi 93 20 metabolic metabolic JJ cord-354900-bzv4yhqi 93 21 changes change NNS cord-354900-bzv4yhqi 93 22 . . . cord-354900-bzv4yhqi 94 1 It -PRON- PRP cord-354900-bzv4yhqi 94 2 has have VBZ cord-354900-bzv4yhqi 94 3 been be VBN cord-354900-bzv4yhqi 94 4 shown show VBN cord-354900-bzv4yhqi 94 5 that that IN cord-354900-bzv4yhqi 94 6 changing change VBG cord-354900-bzv4yhqi 94 7 the the DT cord-354900-bzv4yhqi 94 8 diet diet NN cord-354900-bzv4yhqi 94 9 to to IN cord-354900-bzv4yhqi 94 10 one one CD cord-354900-bzv4yhqi 94 11 rich rich JJ cord-354900-bzv4yhqi 94 12 in in IN cord-354900-bzv4yhqi 94 13 refined refined JJ cord-354900-bzv4yhqi 94 14 carbohydrates carbohydrate NNS cord-354900-bzv4yhqi 94 15 including include VBG cord-354900-bzv4yhqi 94 16 processing processing NN cord-354900-bzv4yhqi 94 17 of of IN cord-354900-bzv4yhqi 94 18 simple simple JJ cord-354900-bzv4yhqi 94 19 sugars sugar NNS cord-354900-bzv4yhqi 94 20 and and CC cord-354900-bzv4yhqi 94 21 animal animal NN cord-354900-bzv4yhqi 94 22 fat fat NN cord-354900-bzv4yhqi 94 23 leads lead VBZ cord-354900-bzv4yhqi 94 24 to to IN cord-354900-bzv4yhqi 94 25 an an DT cord-354900-bzv4yhqi 94 26 important important JJ cord-354900-bzv4yhqi 94 27 disruption disruption NN cord-354900-bzv4yhqi 94 28 of of IN cord-354900-bzv4yhqi 94 29 the the DT cord-354900-bzv4yhqi 94 30 gut gut NN cord-354900-bzv4yhqi 94 31 microbiota microbiota NN cord-354900-bzv4yhqi 94 32 diversity diversity NN cord-354900-bzv4yhqi 94 33 [ [ -LRB- cord-354900-bzv4yhqi 94 34 68 68 CD cord-354900-bzv4yhqi 94 35 ] ] -RRB- cord-354900-bzv4yhqi 94 36 . . . cord-354900-bzv4yhqi 95 1 The the DT cord-354900-bzv4yhqi 95 2 gut gut NN cord-354900-bzv4yhqi 95 3 - - HYPH cord-354900-bzv4yhqi 95 4 lung lung NN cord-354900-bzv4yhqi 95 5 axis axis NN cord-354900-bzv4yhqi 95 6 is be VBZ cord-354900-bzv4yhqi 95 7 well well RB cord-354900-bzv4yhqi 95 8 - - HYPH cord-354900-bzv4yhqi 95 9 known know VBN cord-354900-bzv4yhqi 95 10 through through IN cord-354900-bzv4yhqi 95 11 cell cell NN cord-354900-bzv4yhqi 95 12 wall wall NN cord-354900-bzv4yhqi 95 13 components component NNS cord-354900-bzv4yhqi 95 14 of of IN cord-354900-bzv4yhqi 95 15 the the DT cord-354900-bzv4yhqi 95 16 gut gut NN cord-354900-bzv4yhqi 95 17 microbiota microbiota NN cord-354900-bzv4yhqi 95 18 and and CC cord-354900-bzv4yhqi 95 19 their -PRON- PRP$ cord-354900-bzv4yhqi 95 20 metabolites metabolite NNS cord-354900-bzv4yhqi 95 21 such such JJ cord-354900-bzv4yhqi 95 22 as as IN cord-354900-bzv4yhqi 95 23 short short JJ cord-354900-bzv4yhqi 95 24 - - HYPH cord-354900-bzv4yhqi 95 25 chain chain NN cord-354900-bzv4yhqi 95 26 fatty fatty JJ cord-354900-bzv4yhqi 95 27 acids acid NNS cord-354900-bzv4yhqi 95 28 that that WDT cord-354900-bzv4yhqi 95 29 can can MD cord-354900-bzv4yhqi 95 30 interact interact VB cord-354900-bzv4yhqi 95 31 with with IN cord-354900-bzv4yhqi 95 32 host host NN cord-354900-bzv4yhqi 95 33 PRRs prr NNS cord-354900-bzv4yhqi 95 34 and and CC cord-354900-bzv4yhqi 95 35 modulate modulate VB cord-354900-bzv4yhqi 95 36 the the DT cord-354900-bzv4yhqi 95 37 immune immune JJ cord-354900-bzv4yhqi 95 38 response response NN cord-354900-bzv4yhqi 95 39 [ [ -LRB- cord-354900-bzv4yhqi 95 40 69 69 CD cord-354900-bzv4yhqi 95 41 ] ] -RRB- cord-354900-bzv4yhqi 95 42 [ [ -LRB- cord-354900-bzv4yhqi 95 43 70 70 CD cord-354900-bzv4yhqi 95 44 ] ] -RRB- cord-354900-bzv4yhqi 95 45 [ [ -LRB- cord-354900-bzv4yhqi 95 46 71 71 CD cord-354900-bzv4yhqi 95 47 ] ] -RRB- cord-354900-bzv4yhqi 95 48 . . . cord-354900-bzv4yhqi 96 1 With with IN cord-354900-bzv4yhqi 96 2 regard regard NN cord-354900-bzv4yhqi 96 3 to to IN cord-354900-bzv4yhqi 96 4 the the DT cord-354900-bzv4yhqi 96 5 role role NN cord-354900-bzv4yhqi 96 6 of of IN cord-354900-bzv4yhqi 96 7 the the DT cord-354900-bzv4yhqi 96 8 gut gut NN cord-354900-bzv4yhqi 96 9 microbiota microbiota NN cord-354900-bzv4yhqi 96 10 in in IN cord-354900-bzv4yhqi 96 11 the the DT cord-354900-bzv4yhqi 96 12 immunomodulation immunomodulation NN cord-354900-bzv4yhqi 96 13 of of IN cord-354900-bzv4yhqi 96 14 virus virus NN cord-354900-bzv4yhqi 96 15 infection infection NN cord-354900-bzv4yhqi 96 16 , , , cord-354900-bzv4yhqi 96 17 it -PRON- PRP cord-354900-bzv4yhqi 96 18 has have VBZ cord-354900-bzv4yhqi 96 19 been be VBN cord-354900-bzv4yhqi 96 20 shown show VBN cord-354900-bzv4yhqi 96 21 that that IN cord-354900-bzv4yhqi 96 22 influenza influenza NN cord-354900-bzv4yhqi 96 23 infection infection NN cord-354900-bzv4yhqi 96 24 can can MD cord-354900-bzv4yhqi 96 25 alter alter VB cord-354900-bzv4yhqi 96 26 the the DT cord-354900-bzv4yhqi 96 27 intestinal intestinal JJ cord-354900-bzv4yhqi 96 28 microbial microbial JJ cord-354900-bzv4yhqi 96 29 community community NN cord-354900-bzv4yhqi 96 30 by by IN cord-354900-bzv4yhqi 96 31 reducing reduce VBG cord-354900-bzv4yhqi 96 32 commensal commensal JJ cord-354900-bzv4yhqi 96 33 anaerobic anaerobic JJ cord-354900-bzv4yhqi 96 34 bacteria bacteria NNS cord-354900-bzv4yhqi 96 35 and and CC cord-354900-bzv4yhqi 96 36 increasing increase VBG cord-354900-bzv4yhqi 96 37 the the DT cord-354900-bzv4yhqi 96 38 Proteobacteria Proteobacteria NNP cord-354900-bzv4yhqi 96 39 gut gut NN cord-354900-bzv4yhqi 96 40 population population NN cord-354900-bzv4yhqi 96 41 . . . cord-354900-bzv4yhqi 97 1 This this DT cord-354900-bzv4yhqi 97 2 occurs occur VBZ cord-354900-bzv4yhqi 97 3 via via IN cord-354900-bzv4yhqi 97 4 a a DT cord-354900-bzv4yhqi 97 5 mechanism mechanism NN cord-354900-bzv4yhqi 97 6 that that WDT cord-354900-bzv4yhqi 97 7 is be VBZ cord-354900-bzv4yhqi 97 8 dependent dependent JJ cord-354900-bzv4yhqi 97 9 on on IN cord-354900-bzv4yhqi 97 10 type type NN cord-354900-bzv4yhqi 97 11 I -PRON- PRP cord-354900-bzv4yhqi 97 12 interferons interferon NNS cord-354900-bzv4yhqi 97 13 induced induce VBN cord-354900-bzv4yhqi 97 14 in in IN cord-354900-bzv4yhqi 97 15 the the DT cord-354900-bzv4yhqi 97 16 pulmonary pulmonary JJ cord-354900-bzv4yhqi 97 17 tract tract NN cord-354900-bzv4yhqi 97 18 suggesting suggest VBG cord-354900-bzv4yhqi 97 19 that that IN cord-354900-bzv4yhqi 97 20 influenza influenza NN cord-354900-bzv4yhqi 97 21 - - HYPH cord-354900-bzv4yhqi 97 22 induced induce VBN cord-354900-bzv4yhqi 97 23 type type NN cord-354900-bzv4yhqi 97 24 I -PRON- PRP cord-354900-bzv4yhqi 97 25 interferons interferon NNS cord-354900-bzv4yhqi 97 26 may may MD cord-354900-bzv4yhqi 97 27 facilitate facilitate VB cord-354900-bzv4yhqi 97 28 secondary secondary JJ cord-354900-bzv4yhqi 97 29 Salmonella Salmonella NNP cord-354900-bzv4yhqi 97 30 infection infection NN cord-354900-bzv4yhqi 97 31 [ [ -LRB- cord-354900-bzv4yhqi 97 32 72 72 CD cord-354900-bzv4yhqi 97 33 ] ] -RRB- cord-354900-bzv4yhqi 97 34 . . . cord-354900-bzv4yhqi 98 1 Recently recently RB cord-354900-bzv4yhqi 98 2 , , , cord-354900-bzv4yhqi 98 3 Zhejiang Zhejiang NNP cord-354900-bzv4yhqi 98 4 et et NNP cord-354900-bzv4yhqi 98 5 al al NNP cord-354900-bzv4yhqi 98 6 . . NNP cord-354900-bzv4yhqi 98 7 observed observe VBD cord-354900-bzv4yhqi 98 8 that that IN cord-354900-bzv4yhqi 98 9 some some DT cord-354900-bzv4yhqi 98 10 patients patient NNS cord-354900-bzv4yhqi 98 11 with with IN cord-354900-bzv4yhqi 98 12 COVID-19 COVID-19 NNP cord-354900-bzv4yhqi 98 13 have have VBP cord-354900-bzv4yhqi 98 14 a a DT cord-354900-bzv4yhqi 98 15 disrupted disrupt VBN cord-354900-bzv4yhqi 98 16 gut gut NN cord-354900-bzv4yhqi 98 17 microbiota microbiota NN cord-354900-bzv4yhqi 98 18 with with IN cord-354900-bzv4yhqi 98 19 decreased decrease VBN cord-354900-bzv4yhqi 98 20 Lactobacillus lactobacillus NN cord-354900-bzv4yhqi 98 21 and and CC cord-354900-bzv4yhqi 98 22 Bifidobacterium bifidobacterium NN cord-354900-bzv4yhqi 98 23 populations population NNS cord-354900-bzv4yhqi 98 24 [ [ -LRB- cord-354900-bzv4yhqi 98 25 73 73 CD cord-354900-bzv4yhqi 98 26 ] ] -RRB- cord-354900-bzv4yhqi 98 27 . . . cord-354900-bzv4yhqi 99 1 Nutritional nutritional JJ cord-354900-bzv4yhqi 99 2 support support NN cord-354900-bzv4yhqi 99 3 and and CC cord-354900-bzv4yhqi 99 4 administration administration NN cord-354900-bzv4yhqi 99 5 of of IN cord-354900-bzv4yhqi 99 6 prebiotics prebiotic NNS cord-354900-bzv4yhqi 99 7 or or CC cord-354900-bzv4yhqi 99 8 probiotics probiotic NNS cord-354900-bzv4yhqi 99 9 were be VBD cord-354900-bzv4yhqi 99 10 proposed propose VBN cord-354900-bzv4yhqi 99 11 to to IN cord-354900-bzv4yhqi 99 12 these these DT cord-354900-bzv4yhqi 99 13 COVID-19 covid-19 JJ cord-354900-bzv4yhqi 99 14 patients patient NNS cord-354900-bzv4yhqi 99 15 to to TO cord-354900-bzv4yhqi 99 16 regulate regulate VB cord-354900-bzv4yhqi 99 17 the the DT cord-354900-bzv4yhqi 99 18 balance balance NN cord-354900-bzv4yhqi 99 19 of of IN cord-354900-bzv4yhqi 99 20 the the DT cord-354900-bzv4yhqi 99 21 intestinal intestinal JJ cord-354900-bzv4yhqi 99 22 microbiota microbiota NN cord-354900-bzv4yhqi 99 23 and and CC cord-354900-bzv4yhqi 99 24 reduce reduce VB cord-354900-bzv4yhqi 99 25 the the DT cord-354900-bzv4yhqi 99 26 risk risk NN cord-354900-bzv4yhqi 99 27 of of IN cord-354900-bzv4yhqi 99 28 secondary secondary JJ cord-354900-bzv4yhqi 99 29 infections infection NNS cord-354900-bzv4yhqi 99 30 [ [ -LRB- cord-354900-bzv4yhqi 99 31 73 73 CD cord-354900-bzv4yhqi 99 32 ] ] -RRB- cord-354900-bzv4yhqi 99 33 . . . cord-354900-bzv4yhqi 100 1 It -PRON- PRP cord-354900-bzv4yhqi 100 2 therefore therefore RB cord-354900-bzv4yhqi 100 3 appears appear VBZ cord-354900-bzv4yhqi 100 4 that that IN cord-354900-bzv4yhqi 100 5 it -PRON- PRP cord-354900-bzv4yhqi 100 6 would would MD cord-354900-bzv4yhqi 100 7 be be VB cord-354900-bzv4yhqi 100 8 better well JJR cord-354900-bzv4yhqi 100 9 to to TO cord-354900-bzv4yhqi 100 10 have have VB cord-354900-bzv4yhqi 100 11 a a DT cord-354900-bzv4yhqi 100 12 healthy healthy JJ cord-354900-bzv4yhqi 100 13 gut gut NN cord-354900-bzv4yhqi 100 14 microbiota microbiota NN cord-354900-bzv4yhqi 100 15 with with IN cord-354900-bzv4yhqi 100 16 a a DT cord-354900-bzv4yhqi 100 17 high high JJ cord-354900-bzv4yhqi 100 18 biodiversity biodiversity NN cord-354900-bzv4yhqi 100 19 prior prior RB cord-354900-bzv4yhqi 100 20 to to IN cord-354900-bzv4yhqi 100 21 any any DT cord-354900-bzv4yhqi 100 22 viral viral JJ cord-354900-bzv4yhqi 100 23 infection infection NN cord-354900-bzv4yhqi 100 24 including include VBG cord-354900-bzv4yhqi 100 25 coronavirus coronavirus NN cord-354900-bzv4yhqi 100 26 . . . cord-354900-bzv4yhqi 101 1 Overall overall RB cord-354900-bzv4yhqi 101 2 , , , cord-354900-bzv4yhqi 101 3 a a DT cord-354900-bzv4yhqi 101 4 combination combination NN cord-354900-bzv4yhqi 101 5 of of IN cord-354900-bzv4yhqi 101 6 baker baker NNP cord-354900-bzv4yhqi 101 7 's 's POS cord-354900-bzv4yhqi 101 8 yeast yeast NN cord-354900-bzv4yhqi 101 9 β β NN cord-354900-bzv4yhqi 101 10 - - HYPH cord-354900-bzv4yhqi 101 11 glucan glucan NNP cord-354900-bzv4yhqi 101 12 as as IN cord-354900-bzv4yhqi 101 13 a a DT cord-354900-bzv4yhqi 101 14 prophylactic prophylactic JJ cord-354900-bzv4yhqi 101 15 option option NN cord-354900-bzv4yhqi 101 16 , , , cord-354900-bzv4yhqi 101 17 with with IN cord-354900-bzv4yhqi 101 18 a a DT cord-354900-bzv4yhqi 101 19 healthy healthy JJ cord-354900-bzv4yhqi 101 20 diet diet NN cord-354900-bzv4yhqi 101 21 rich rich JJ cord-354900-bzv4yhqi 101 22 in in IN cord-354900-bzv4yhqi 101 23 natural natural JJ cord-354900-bzv4yhqi 101 24 vitamins vitamin NNS cord-354900-bzv4yhqi 101 25 C c NN cord-354900-bzv4yhqi 101 26 and and CC cord-354900-bzv4yhqi 101 27 D D NNP cord-354900-bzv4yhqi 101 28 , , , cord-354900-bzv4yhqi 101 29 can can MD cord-354900-bzv4yhqi 101 30 provide provide VB cord-354900-bzv4yhqi 101 31 synergistic synergistic JJ cord-354900-bzv4yhqi 101 32 immune immune JJ cord-354900-bzv4yhqi 101 33 system system NN cord-354900-bzv4yhqi 101 34 support support NN cord-354900-bzv4yhqi 101 35 , , , cord-354900-bzv4yhqi 101 36 helping help VBG cord-354900-bzv4yhqi 101 37 the the DT cord-354900-bzv4yhqi 101 38 body body NN cord-354900-bzv4yhqi 101 39 to to TO cord-354900-bzv4yhqi 101 40 naturally naturally RB cord-354900-bzv4yhqi 101 41 defend defend VB cord-354900-bzv4yhqi 101 42 against against IN cord-354900-bzv4yhqi 101 43 viruses virus NNS cord-354900-bzv4yhqi 101 44 . . . cord-354900-bzv4yhqi 102 1 Finally finally RB cord-354900-bzv4yhqi 102 2 , , , cord-354900-bzv4yhqi 102 3 although although IN cord-354900-bzv4yhqi 102 4 all all PDT cord-354900-bzv4yhqi 102 5 these these DT cord-354900-bzv4yhqi 102 6 strategies strategy NNS cord-354900-bzv4yhqi 102 7 developed develop VBN cord-354900-bzv4yhqi 102 8 in in IN cord-354900-bzv4yhqi 102 9 this this DT cord-354900-bzv4yhqi 102 10 short short JJ cord-354900-bzv4yhqi 102 11 review review NN cord-354900-bzv4yhqi 102 12 can can MD cord-354900-bzv4yhqi 102 13 help help VB cord-354900-bzv4yhqi 102 14 to to TO cord-354900-bzv4yhqi 102 15 naturally naturally RB cord-354900-bzv4yhqi 102 16 improve improve VB cord-354900-bzv4yhqi 102 17 our -PRON- PRP$ cord-354900-bzv4yhqi 102 18 immune immune JJ cord-354900-bzv4yhqi 102 19 response response NN cord-354900-bzv4yhqi 102 20 against against IN cord-354900-bzv4yhqi 102 21 any any DT cord-354900-bzv4yhqi 102 22 viral viral JJ cord-354900-bzv4yhqi 102 23 infection infection NN cord-354900-bzv4yhqi 102 24 , , , cord-354900-bzv4yhqi 102 25 still still RB cord-354900-bzv4yhqi 102 26 the the DT cord-354900-bzv4yhqi 102 27 vaccine vaccine NN cord-354900-bzv4yhqi 102 28 , , , cord-354900-bzv4yhqi 102 29 such such JJ cord-354900-bzv4yhqi 102 30 as as IN cord-354900-bzv4yhqi 102 31 the the DT cord-354900-bzv4yhqi 102 32 SARS SARS NNP cord-354900-bzv4yhqi 102 33 - - HYPH cord-354900-bzv4yhqi 102 34 CoV-2 CoV-2 NNP cord-354900-bzv4yhqi 102 35 vaccine vaccine NN cord-354900-bzv4yhqi 102 36 when when WRB cord-354900-bzv4yhqi 102 37 it -PRON- PRP cord-354900-bzv4yhqi 102 38 will will MD cord-354900-bzv4yhqi 102 39 be be VB cord-354900-bzv4yhqi 102 40 widely widely RB cord-354900-bzv4yhqi 102 41 available available JJ cord-354900-bzv4yhqi 102 42 , , , cord-354900-bzv4yhqi 102 43 is be VBZ cord-354900-bzv4yhqi 102 44 the the DT cord-354900-bzv4yhqi 102 45 best good JJS cord-354900-bzv4yhqi 102 46 option option NN cord-354900-bzv4yhqi 102 47 to to TO cord-354900-bzv4yhqi 102 48 efficiently efficiently RB cord-354900-bzv4yhqi 102 49 stop stop VB cord-354900-bzv4yhqi 102 50 further further JJ cord-354900-bzv4yhqi 102 51 spread spread NN cord-354900-bzv4yhqi 102 52 of of IN cord-354900-bzv4yhqi 102 53 this this DT cord-354900-bzv4yhqi 102 54 virus virus NN cord-354900-bzv4yhqi 102 55 causing cause VBG cord-354900-bzv4yhqi 102 56 the the DT cord-354900-bzv4yhqi 102 57 deadly deadly JJ cord-354900-bzv4yhqi 102 58 COVID-19 covid-19 NN cord-354900-bzv4yhqi 102 59 . . . cord-354900-bzv4yhqi 103 1 Hypothesis hypothesis NN cord-354900-bzv4yhqi 103 2 for for IN cord-354900-bzv4yhqi 103 3 potential potential JJ cord-354900-bzv4yhqi 103 4 pathogenesis pathogenesis NN cord-354900-bzv4yhqi 103 5 of of IN cord-354900-bzv4yhqi 103 6 SARS SARS NNP cord-354900-bzv4yhqi 103 7 - - HYPH cord-354900-bzv4yhqi 103 8 CoV-2 CoV-2 NNP cord-354900-bzv4yhqi 103 9 infection infection NN cord-354900-bzv4yhqi 103 10 - - : cord-354900-bzv4yhqi 103 11 a a DT cord-354900-bzv4yhqi 103 12 review review NN cord-354900-bzv4yhqi 103 13 of of IN cord-354900-bzv4yhqi 103 14 immune immune JJ cord-354900-bzv4yhqi 103 15 changes change NNS cord-354900-bzv4yhqi 103 16 in in IN cord-354900-bzv4yhqi 103 17 patients patient NNS cord-354900-bzv4yhqi 103 18 with with IN cord-354900-bzv4yhqi 103 19 viral viral JJ cord-354900-bzv4yhqi 103 20 pneumonia pneumonia NN cord-354900-bzv4yhqi 104 1 Could Could MD cord-354900-bzv4yhqi 104 2 intravenous intravenous JJ cord-354900-bzv4yhqi 104 3 immunoglobulin immunoglobulin NN cord-354900-bzv4yhqi 104 4 collected collect VBN cord-354900-bzv4yhqi 104 5 from from IN cord-354900-bzv4yhqi 104 6 recovered recover VBN cord-354900-bzv4yhqi 104 7 coronavirus coronavirus NN cord-354900-bzv4yhqi 104 8 patients patient NNS cord-354900-bzv4yhqi 104 9 protect protect VBP cord-354900-bzv4yhqi 104 10 against against IN cord-354900-bzv4yhqi 104 11 COVID-19 COVID-19 NNP cord-354900-bzv4yhqi 104 12 and and CC cord-354900-bzv4yhqi 104 13 strengthen strengthen VB cord-354900-bzv4yhqi 104 14 the the DT cord-354900-bzv4yhqi 104 15 immune immune JJ cord-354900-bzv4yhqi 104 16 system system NN cord-354900-bzv4yhqi 104 17 of of IN cord-354900-bzv4yhqi 104 18 new new JJ cord-354900-bzv4yhqi 104 19 patients patient NNS cord-354900-bzv4yhqi 104 20 ? ? . cord-354900-bzv4yhqi 105 1 Can Can MD cord-354900-bzv4yhqi 105 2 drinking drink VBG cord-354900-bzv4yhqi 105 3 microfiltered microfiltered JJ cord-354900-bzv4yhqi 105 4 raw raw JJ cord-354900-bzv4yhqi 105 5 immune immune JJ cord-354900-bzv4yhqi 105 6 milk milk NN cord-354900-bzv4yhqi 105 7 from from IN cord-354900-bzv4yhqi 105 8 cows cow NNS cord-354900-bzv4yhqi 105 9 immunized immunize VBN cord-354900-bzv4yhqi 105 10 against against IN cord-354900-bzv4yhqi 105 11 SARS SARS NNP cord-354900-bzv4yhqi 105 12 - - : cord-354900-bzv4yhqi 105 13 CoV-2 CoV-2 NNP cord-354900-bzv4yhqi 105 14 provide provide VB cord-354900-bzv4yhqi 105 15 short short JJ cord-354900-bzv4yhqi 105 16 - - HYPH cord-354900-bzv4yhqi 105 17 term term NN cord-354900-bzv4yhqi 105 18 protection protection NN cord-354900-bzv4yhqi 105 19 against against IN cord-354900-bzv4yhqi 105 20 COVID-19 COVID-19 NNP cord-354900-bzv4yhqi 105 21 ? ? . cord-354900-bzv4yhqi 106 1 Structure structure NN cord-354900-bzv4yhqi 106 2 , , , cord-354900-bzv4yhqi 106 3 function function NN cord-354900-bzv4yhqi 106 4 , , , cord-354900-bzv4yhqi 106 5 and and CC cord-354900-bzv4yhqi 106 6 evolution evolution NN cord-354900-bzv4yhqi 106 7 of of IN cord-354900-bzv4yhqi 106 8 Coronavirus Coronavirus NNP cord-354900-bzv4yhqi 106 9 spike spike NN cord-354900-bzv4yhqi 106 10 proteins protein NNS cord-354900-bzv4yhqi 107 1 Genomic genomic JJ cord-354900-bzv4yhqi 107 2 characterization characterization NN cord-354900-bzv4yhqi 107 3 and and CC cord-354900-bzv4yhqi 107 4 infectivity infectivity NN cord-354900-bzv4yhqi 107 5 of of IN cord-354900-bzv4yhqi 107 6 a a DT cord-354900-bzv4yhqi 107 7 novel novel JJ cord-354900-bzv4yhqi 107 8 SARS SARS NNP cord-354900-bzv4yhqi 107 9 - - HYPH cord-354900-bzv4yhqi 107 10 like like JJ cord-354900-bzv4yhqi 107 11 coronavirus coronavirus NN cord-354900-bzv4yhqi 107 12 in in IN cord-354900-bzv4yhqi 107 13 Chinese chinese JJ cord-354900-bzv4yhqi 107 14 bats bat NNS cord-354900-bzv4yhqi 108 1 A a DT cord-354900-bzv4yhqi 108 2 familial familial JJ cord-354900-bzv4yhqi 108 3 cluster cluster NN cord-354900-bzv4yhqi 108 4 of of IN cord-354900-bzv4yhqi 108 5 pneumonia pneumonia NN cord-354900-bzv4yhqi 108 6 associated associate VBN cord-354900-bzv4yhqi 108 7 with with IN cord-354900-bzv4yhqi 108 8 the the DT cord-354900-bzv4yhqi 108 9 2019 2019 CD cord-354900-bzv4yhqi 108 10 novel novel NN cord-354900-bzv4yhqi 108 11 coronavirus coronavirus NN cord-354900-bzv4yhqi 108 12 indicating indicate VBG cord-354900-bzv4yhqi 108 13 person person NN cord-354900-bzv4yhqi 108 14 - - HYPH cord-354900-bzv4yhqi 108 15 to to IN cord-354900-bzv4yhqi 108 16 - - HYPH cord-354900-bzv4yhqi 108 17 person person NN cord-354900-bzv4yhqi 108 18 transmission transmission NN cord-354900-bzv4yhqi 108 19 : : : cord-354900-bzv4yhqi 109 1 a a DT cord-354900-bzv4yhqi 109 2 study study NN cord-354900-bzv4yhqi 109 3 of of IN cord-354900-bzv4yhqi 109 4 a a DT cord-354900-bzv4yhqi 109 5 family family NN cord-354900-bzv4yhqi 109 6 cluster cluster NN cord-354900-bzv4yhqi 109 7 On on IN cord-354900-bzv4yhqi 109 8 the the DT cord-354900-bzv4yhqi 109 9 origin origin NN cord-354900-bzv4yhqi 109 10 and and CC cord-354900-bzv4yhqi 109 11 continuing continue VBG cord-354900-bzv4yhqi 109 12 evolution evolution NN cord-354900-bzv4yhqi 109 13 of of IN cord-354900-bzv4yhqi 109 14 SARS SARS NNP cord-354900-bzv4yhqi 109 15 - - HYPH cord-354900-bzv4yhqi 109 16 CoV-2 CoV-2 NNP cord-354900-bzv4yhqi 109 17 Genomic genomic JJ cord-354900-bzv4yhqi 109 18 characterisation characterisation NN cord-354900-bzv4yhqi 109 19 and and CC cord-354900-bzv4yhqi 109 20 epidemiology epidemiology NN cord-354900-bzv4yhqi 109 21 of of IN cord-354900-bzv4yhqi 109 22 2019 2019 CD cord-354900-bzv4yhqi 109 23 novel novel JJ cord-354900-bzv4yhqi 109 24 coronavirus coronavirus NN cord-354900-bzv4yhqi 109 25 : : : cord-354900-bzv4yhqi 109 26 implications implication NNS cord-354900-bzv4yhqi 109 27 for for IN cord-354900-bzv4yhqi 109 28 virus virus NN cord-354900-bzv4yhqi 109 29 origins origin NNS cord-354900-bzv4yhqi 109 30 and and CC cord-354900-bzv4yhqi 109 31 receptor receptor NN cord-354900-bzv4yhqi 109 32 binding bind VBG cord-354900-bzv4yhqi 109 33 SARS SARS NNP cord-354900-bzv4yhqi 109 34 - - HYPH cord-354900-bzv4yhqi 109 35 CoV-2 CoV-2 NNP cord-354900-bzv4yhqi 109 36 cell cell NN cord-354900-bzv4yhqi 109 37 entry entry NN cord-354900-bzv4yhqi 109 38 depends depend VBZ cord-354900-bzv4yhqi 109 39 on on IN cord-354900-bzv4yhqi 109 40 ACE2 ACE2 NNP cord-354900-bzv4yhqi 109 41 and and CC cord-354900-bzv4yhqi 109 42 TMPRSS2 TMPRSS2 NNP cord-354900-bzv4yhqi 109 43 and and CC cord-354900-bzv4yhqi 109 44 is be VBZ cord-354900-bzv4yhqi 109 45 blocked block VBN cord-354900-bzv4yhqi 109 46 by by IN cord-354900-bzv4yhqi 109 47 a a DT cord-354900-bzv4yhqi 109 48 clinically clinically RB cord-354900-bzv4yhqi 109 49 proven prove VBN cord-354900-bzv4yhqi 109 50 protease protease NN cord-354900-bzv4yhqi 109 51 inhibitor inhibitor NN cord-354900-bzv4yhqi 109 52 COVID-19 covid-19 NN cord-354900-bzv4yhqi 109 53 : : : cord-354900-bzv4yhqi 109 54 gastrointestinal gastrointestinal JJ cord-354900-bzv4yhqi 109 55 manifestations manifestation NNS cord-354900-bzv4yhqi 109 56 and and CC cord-354900-bzv4yhqi 109 57 potential potential JJ cord-354900-bzv4yhqi 109 58 fecal fecal JJ cord-354900-bzv4yhqi 109 59 - - HYPH cord-354900-bzv4yhqi 109 60 oral oral JJ cord-354900-bzv4yhqi 109 61 transmission transmission NN cord-354900-bzv4yhqi 109 62 SARS SARS NNP cord-354900-bzv4yhqi 109 63 - - HYPH cord-354900-bzv4yhqi 109 64 CoV-2 CoV-2 NNP cord-354900-bzv4yhqi 109 65 cell cell NN cord-354900-bzv4yhqi 109 66 entry entry NN cord-354900-bzv4yhqi 109 67 depends depend VBZ cord-354900-bzv4yhqi 109 68 on on IN cord-354900-bzv4yhqi 109 69 ACE2 ACE2 NNP cord-354900-bzv4yhqi 109 70 and and CC cord-354900-bzv4yhqi 109 71 TMPRSS2 TMPRSS2 NNP cord-354900-bzv4yhqi 109 72 and and CC cord-354900-bzv4yhqi 109 73 is be VBZ cord-354900-bzv4yhqi 109 74 blocked block VBN cord-354900-bzv4yhqi 109 75 by by IN cord-354900-bzv4yhqi 109 76 a a DT cord-354900-bzv4yhqi 109 77 clinically clinically RB cord-354900-bzv4yhqi 109 78 proven prove VBN cord-354900-bzv4yhqi 109 79 protease protease NN cord-354900-bzv4yhqi 109 80 inhibitor inhibitor NN cord-354900-bzv4yhqi 109 81 A a DT cord-354900-bzv4yhqi 109 82 familial familial JJ cord-354900-bzv4yhqi 109 83 cluster cluster NN cord-354900-bzv4yhqi 109 84 of of IN cord-354900-bzv4yhqi 109 85 pneumonia pneumonia NN cord-354900-bzv4yhqi 109 86 associated associate VBN cord-354900-bzv4yhqi 109 87 with with IN cord-354900-bzv4yhqi 109 88 the the DT cord-354900-bzv4yhqi 109 89 2019 2019 CD cord-354900-bzv4yhqi 109 90 novel novel NN cord-354900-bzv4yhqi 109 91 coronavirus coronavirus NN cord-354900-bzv4yhqi 109 92 indicating indicate VBG cord-354900-bzv4yhqi 109 93 person person NN cord-354900-bzv4yhqi 109 94 - - HYPH cord-354900-bzv4yhqi 109 95 to to IN cord-354900-bzv4yhqi 109 96 - - HYPH cord-354900-bzv4yhqi 109 97 person person NN cord-354900-bzv4yhqi 109 98 transmission transmission NN cord-354900-bzv4yhqi 109 99 : : : cord-354900-bzv4yhqi 109 100 a a DT cord-354900-bzv4yhqi 109 101 study study NN cord-354900-bzv4yhqi 109 102 of of IN cord-354900-bzv4yhqi 109 103 a a DT cord-354900-bzv4yhqi 109 104 family family NN cord-354900-bzv4yhqi 109 105 cluster cluster NN cord-354900-bzv4yhqi 109 106 Bat Bat NNP cord-354900-bzv4yhqi 109 107 Coronaviruses Coronaviruses NNPS cord-354900-bzv4yhqi 109 108 in in IN cord-354900-bzv4yhqi 109 109 China China NNP cord-354900-bzv4yhqi 109 110 Digestive digestive JJ cord-354900-bzv4yhqi 109 111 symptoms symptom NNS cord-354900-bzv4yhqi 109 112 in in IN cord-354900-bzv4yhqi 109 113 COVID-19 covid-19 JJ cord-354900-bzv4yhqi 109 114 patients patient NNS cord-354900-bzv4yhqi 109 115 with with IN cord-354900-bzv4yhqi 109 116 mild mild JJ cord-354900-bzv4yhqi 109 117 disease disease NN cord-354900-bzv4yhqi 109 118 severity severity NN cord-354900-bzv4yhqi 109 119 : : : cord-354900-bzv4yhqi 109 120 clinical clinical JJ cord-354900-bzv4yhqi 109 121 presentation presentation NN cord-354900-bzv4yhqi 109 122 , , , cord-354900-bzv4yhqi 109 123 stool stool NN cord-354900-bzv4yhqi 109 124 viral viral JJ cord-354900-bzv4yhqi 109 125 RNA RNA NNP cord-354900-bzv4yhqi 109 126 testing testing NN cord-354900-bzv4yhqi 109 127 , , , cord-354900-bzv4yhqi 109 128 and and CC cord-354900-bzv4yhqi 109 129 outcomes outcome NNS cord-354900-bzv4yhqi 109 130 Recognition Recognition NNP cord-354900-bzv4yhqi 109 131 of of IN cord-354900-bzv4yhqi 109 132 doublestranded doublestranded NNP cord-354900-bzv4yhqi 109 133 RNA RNA NNP cord-354900-bzv4yhqi 109 134 and and CC cord-354900-bzv4yhqi 109 135 activation activation NN cord-354900-bzv4yhqi 109 136 of of IN cord-354900-bzv4yhqi 109 137 NF NF NNP cord-354900-bzv4yhqi 109 138 - - HYPH cord-354900-bzv4yhqi 109 139 kappaB kappaB NNP cord-354900-bzv4yhqi 109 140 by by IN cord-354900-bzv4yhqi 109 141 Toll Toll NNP cord-354900-bzv4yhqi 109 142 - - HYPH cord-354900-bzv4yhqi 109 143 like like JJ cord-354900-bzv4yhqi 109 144 receptor receptor NN cord-354900-bzv4yhqi 109 145 3 3 CD cord-354900-bzv4yhqi 109 146 Innate innate JJ cord-354900-bzv4yhqi 109 147 immune immune JJ cord-354900-bzv4yhqi 109 148 sensing sensing NN cord-354900-bzv4yhqi 109 149 and and CC cord-354900-bzv4yhqi 109 150 signaling signaling NN cord-354900-bzv4yhqi 109 151 of of IN cord-354900-bzv4yhqi 109 152 cytosolic cytosolic JJ cord-354900-bzv4yhqi 109 153 nucleic nucleic JJ cord-354900-bzv4yhqi 109 154 acids acid NNS cord-354900-bzv4yhqi 109 155 Sensing sense VBG cord-354900-bzv4yhqi 109 156 viral viral JJ cord-354900-bzv4yhqi 109 157 invasion invasion NN cord-354900-bzv4yhqi 109 158 by by IN cord-354900-bzv4yhqi 109 159 RIG rig NN cord-354900-bzv4yhqi 109 160 - - : cord-354900-bzv4yhqi 109 161 I -PRON- PRP cord-354900-bzv4yhqi 109 162 like like VBP cord-354900-bzv4yhqi 110 1 receptors receptor NNS cord-354900-bzv4yhqi 110 2 Cyclic Cyclic NNP cord-354900-bzv4yhqi 110 3 GMP GMP NNP cord-354900-bzv4yhqi 110 4 - - HYPH cord-354900-bzv4yhqi 110 5 AMP AMP NNP cord-354900-bzv4yhqi 110 6 is be VBZ cord-354900-bzv4yhqi 110 7 an an DT cord-354900-bzv4yhqi 110 8 endogenous endogenous JJ cord-354900-bzv4yhqi 110 9 second second JJ cord-354900-bzv4yhqi 110 10 messenger messenger NN cord-354900-bzv4yhqi 110 11 in in IN cord-354900-bzv4yhqi 110 12 innate innate JJ cord-354900-bzv4yhqi 110 13 immune immune JJ cord-354900-bzv4yhqi 110 14 signaling signaling NN cord-354900-bzv4yhqi 110 15 by by IN cord-354900-bzv4yhqi 110 16 cytosolic cytosolic JJ cord-354900-bzv4yhqi 110 17 DNA DNA NNP cord-354900-bzv4yhqi 110 18 Toll Toll NNP cord-354900-bzv4yhqi 110 19 - - HYPH cord-354900-bzv4yhqi 110 20 like like JJ cord-354900-bzv4yhqi 110 21 receptor receptor NN cord-354900-bzv4yhqi 110 22 signaling signal VBG cord-354900-bzv4yhqi 110 23 pathways pathway NNS cord-354900-bzv4yhqi 111 1 Clinical clinical JJ cord-354900-bzv4yhqi 111 2 features feature NNS cord-354900-bzv4yhqi 111 3 of of IN cord-354900-bzv4yhqi 111 4 patients patient NNS cord-354900-bzv4yhqi 111 5 infected infect VBN cord-354900-bzv4yhqi 111 6 with with IN cord-354900-bzv4yhqi 111 7 2019 2019 CD cord-354900-bzv4yhqi 111 8 novel novel JJ cord-354900-bzv4yhqi 111 9 coronavirus coronavirus NN cord-354900-bzv4yhqi 111 10 in in IN cord-354900-bzv4yhqi 111 11 Wuhan Wuhan NNP cord-354900-bzv4yhqi 111 12 Advances advance VBZ cord-354900-bzv4yhqi 111 13 in in IN cord-354900-bzv4yhqi 111 14 the the DT cord-354900-bzv4yhqi 111 15 research research NN cord-354900-bzv4yhqi 111 16 of of IN cord-354900-bzv4yhqi 111 17 cytokine cytokine NN cord-354900-bzv4yhqi 111 18 storm storm NN cord-354900-bzv4yhqi 111 19 mechanism mechanism NN cord-354900-bzv4yhqi 111 20 induced induce VBN cord-354900-bzv4yhqi 111 21 by by IN cord-354900-bzv4yhqi 111 22 Corona Corona NNP cord-354900-bzv4yhqi 111 23 Virus Virus NNP cord-354900-bzv4yhqi 111 24 Disease Disease NNP cord-354900-bzv4yhqi 111 25 2019 2019 CD cord-354900-bzv4yhqi 111 26 and and CC cord-354900-bzv4yhqi 111 27 the the DT cord-354900-bzv4yhqi 111 28 corresponding correspond VBG cord-354900-bzv4yhqi 111 29 immunotherapies immunotherapy NNS cord-354900-bzv4yhqi 111 30 Cell cell NN cord-354900-bzv4yhqi 111 31 wall wall NN cord-354900-bzv4yhqi 111 32 beta-(1,6)-glucan beta-(1,6)-glucan '' cord-354900-bzv4yhqi 111 33 of of IN cord-354900-bzv4yhqi 111 34 Saccharomyces Saccharomyces NNP cord-354900-bzv4yhqi 111 35 cerevisiae cerevisiae NNS cord-354900-bzv4yhqi 111 36 : : : cord-354900-bzv4yhqi 111 37 structural structural JJ cord-354900-bzv4yhqi 111 38 characterization characterization NN cord-354900-bzv4yhqi 111 39 and and CC cord-354900-bzv4yhqi 111 40 in in IN cord-354900-bzv4yhqi 111 41 situ situ JJ cord-354900-bzv4yhqi 111 42 synthesis synthesis NN cord-354900-bzv4yhqi 111 43 Modulation modulation NN cord-354900-bzv4yhqi 111 44 of of IN cord-354900-bzv4yhqi 111 45 intestinal intestinal JJ cord-354900-bzv4yhqi 111 46 inflammation inflammation NN cord-354900-bzv4yhqi 111 47 by by IN cord-354900-bzv4yhqi 111 48 yeasts yeast NNS cord-354900-bzv4yhqi 111 49 and and CC cord-354900-bzv4yhqi 111 50 cell cell NN cord-354900-bzv4yhqi 111 51 wall wall NN cord-354900-bzv4yhqi 111 52 extracts extract NNS cord-354900-bzv4yhqi 111 53 : : : cord-354900-bzv4yhqi 112 1 strain strain VB cord-354900-bzv4yhqi 112 2 dependence dependence NN cord-354900-bzv4yhqi 112 3 and and CC cord-354900-bzv4yhqi 112 4 unexpected unexpected JJ cord-354900-bzv4yhqi 112 5 anti anti JJ cord-354900-bzv4yhqi 112 6 - - JJ cord-354900-bzv4yhqi 112 7 inflammatory inflammatory JJ cord-354900-bzv4yhqi 112 8 role role NN cord-354900-bzv4yhqi 112 9 of of IN cord-354900-bzv4yhqi 112 10 glucan glucan NN cord-354900-bzv4yhqi 112 11 fractions fraction NNS cord-354900-bzv4yhqi 112 12 How how WRB cord-354900-bzv4yhqi 112 13 fungal fungal JJ cord-354900-bzv4yhqi 112 14 glycans glycan NNS cord-354900-bzv4yhqi 112 15 modulate modulate VBP cord-354900-bzv4yhqi 112 16 platelet platelet NN cord-354900-bzv4yhqi 112 17 activation activation NN cord-354900-bzv4yhqi 112 18 via via IN cord-354900-bzv4yhqi 112 19 toll toll NN cord-354900-bzv4yhqi 112 20 - - HYPH cord-354900-bzv4yhqi 112 21 like like JJ cord-354900-bzv4yhqi 112 22 receptors receptor NNS cord-354900-bzv4yhqi 112 23 contributing contribute VBG cord-354900-bzv4yhqi 112 24 to to IN cord-354900-bzv4yhqi 112 25 the the DT cord-354900-bzv4yhqi 112 26 escape escape NN cord-354900-bzv4yhqi 112 27 of of IN cord-354900-bzv4yhqi 112 28 Candida Candida NNP cord-354900-bzv4yhqi 112 29 albicans albican NNS cord-354900-bzv4yhqi 112 30 from from IN cord-354900-bzv4yhqi 112 31 the the DT cord-354900-bzv4yhqi 112 32 immune immune JJ cord-354900-bzv4yhqi 112 33 rResponse rResponse NNP cord-354900-bzv4yhqi 112 34 Effects effect NNS cord-354900-bzv4yhqi 112 35 of of IN cord-354900-bzv4yhqi 112 36 betaglucans betaglucan NNS cord-354900-bzv4yhqi 112 37 on on IN cord-354900-bzv4yhqi 112 38 the the DT cord-354900-bzv4yhqi 112 39 immune immune JJ cord-354900-bzv4yhqi 112 40 system system NN cord-354900-bzv4yhqi 113 1 Training train VBG cord-354900-bzv4yhqi 113 2 innate innate JJ cord-354900-bzv4yhqi 113 3 immunity immunity NN cord-354900-bzv4yhqi 113 4 : : : cord-354900-bzv4yhqi 113 5 the the DT cord-354900-bzv4yhqi 113 6 changing change VBG cord-354900-bzv4yhqi 113 7 concept concept NN cord-354900-bzv4yhqi 113 8 of of IN cord-354900-bzv4yhqi 113 9 immunological immunological JJ cord-354900-bzv4yhqi 113 10 memory memory NN cord-354900-bzv4yhqi 113 11 in in IN cord-354900-bzv4yhqi 113 12 innate innate JJ cord-354900-bzv4yhqi 113 13 host host NN cord-354900-bzv4yhqi 113 14 defence defence NN cord-354900-bzv4yhqi 113 15 Trained trained JJ cord-354900-bzv4yhqi 113 16 immunity immunity NN cord-354900-bzv4yhqi 113 17 : : : cord-354900-bzv4yhqi 113 18 A a DT cord-354900-bzv4yhqi 113 19 program program NN cord-354900-bzv4yhqi 113 20 of of IN cord-354900-bzv4yhqi 113 21 innate innate JJ cord-354900-bzv4yhqi 113 22 immune immune JJ cord-354900-bzv4yhqi 113 23 memory memory NN cord-354900-bzv4yhqi 113 24 in in IN cord-354900-bzv4yhqi 113 25 health health NN cord-354900-bzv4yhqi 113 26 and and CC cord-354900-bzv4yhqi 113 27 disease disease NN cord-354900-bzv4yhqi 114 1 Histone histone JJ cord-354900-bzv4yhqi 114 2 methylation methylation NN cord-354900-bzv4yhqi 114 3 : : : cord-354900-bzv4yhqi 114 4 a a DT cord-354900-bzv4yhqi 114 5 dynamic dynamic JJ cord-354900-bzv4yhqi 114 6 mark mark NN cord-354900-bzv4yhqi 114 7 in in IN cord-354900-bzv4yhqi 114 8 health health NN cord-354900-bzv4yhqi 114 9 , , , cord-354900-bzv4yhqi 114 10 disease disease NN cord-354900-bzv4yhqi 114 11 and and CC cord-354900-bzv4yhqi 114 12 inheritance inheritance NN cord-354900-bzv4yhqi 114 13 Beyond beyond IN cord-354900-bzv4yhqi 114 14 receptors receptor NNS cord-354900-bzv4yhqi 114 15 and and CC cord-354900-bzv4yhqi 114 16 signaling signal VBG cord-354900-bzv4yhqi 114 17 : : : cord-354900-bzv4yhqi 115 1 epigenetic epigenetic JJ cord-354900-bzv4yhqi 115 2 factors factor NNS cord-354900-bzv4yhqi 115 3 in in IN cord-354900-bzv4yhqi 115 4 the the DT cord-354900-bzv4yhqi 115 5 regulation regulation NN cord-354900-bzv4yhqi 115 6 of of IN cord-354900-bzv4yhqi 115 7 innate innate JJ cord-354900-bzv4yhqi 115 8 immunity immunity NN cord-354900-bzv4yhqi 115 9 Oral oral JJ cord-354900-bzv4yhqi 115 10 administration administration NN cord-354900-bzv4yhqi 115 11 of of IN cord-354900-bzv4yhqi 115 12 soluble soluble JJ cord-354900-bzv4yhqi 115 13 beta beta NN cord-354900-bzv4yhqi 115 14 - - HYPH cord-354900-bzv4yhqi 115 15 glucans glucan NNS cord-354900-bzv4yhqi 115 16 extracted extract VBN cord-354900-bzv4yhqi 115 17 from from IN cord-354900-bzv4yhqi 115 18 Grifola Grifola NNP cord-354900-bzv4yhqi 115 19 frondosa frondosa NNP cord-354900-bzv4yhqi 115 20 induces induce VBZ cord-354900-bzv4yhqi 115 21 systemic systemic JJ cord-354900-bzv4yhqi 115 22 antitumor antitumor JJ cord-354900-bzv4yhqi 115 23 immune immune JJ cord-354900-bzv4yhqi 115 24 response response NN cord-354900-bzv4yhqi 115 25 and and CC cord-354900-bzv4yhqi 115 26 decreases decrease VBZ cord-354900-bzv4yhqi 115 27 immunosuppression immunosuppression NN cord-354900-bzv4yhqi 115 28 in in IN cord-354900-bzv4yhqi 115 29 tumor tumor NN cord-354900-bzv4yhqi 115 30 - - HYPH cord-354900-bzv4yhqi 115 31 bearing bear VBG cord-354900-bzv4yhqi 115 32 mice mouse NNS cord-354900-bzv4yhqi 116 1 A a DT cord-354900-bzv4yhqi 116 2 decrease decrease NN cord-354900-bzv4yhqi 116 3 in in IN cord-354900-bzv4yhqi 116 4 anaerobic anaerobic JJ cord-354900-bzv4yhqi 116 5 bacteria bacteria NNS cord-354900-bzv4yhqi 116 6 promotes promote VBZ cord-354900-bzv4yhqi 116 7 Candida Candida NNP cord-354900-bzv4yhqi 116 8 glabrata glabrata NN cord-354900-bzv4yhqi 116 9 overgrowth overgrowth NN cord-354900-bzv4yhqi 116 10 while while IN cord-354900-bzv4yhqi 116 11 beta beta NN cord-354900-bzv4yhqi 116 12 - - HYPH cord-354900-bzv4yhqi 116 13 glucan glucan JJ cord-354900-bzv4yhqi 116 14 treatment treatment NN cord-354900-bzv4yhqi 116 15 restores restore VBZ cord-354900-bzv4yhqi 116 16 the the DT cord-354900-bzv4yhqi 116 17 gut gut NN cord-354900-bzv4yhqi 116 18 microbiota microbiota NN cord-354900-bzv4yhqi 116 19 and and CC cord-354900-bzv4yhqi 116 20 attenuates attenuate VBZ cord-354900-bzv4yhqi 116 21 colitis colitis NN cord-354900-bzv4yhqi 116 22 Antiviral antiviral JJ cord-354900-bzv4yhqi 116 23 effect effect NN cord-354900-bzv4yhqi 116 24 of of IN cord-354900-bzv4yhqi 116 25 Saccharomyces saccharomyce NNS cord-354900-bzv4yhqi 116 26 cerevisiae cerevisiae VBZ cord-354900-bzv4yhqi 116 27 beta beta NN cord-354900-bzv4yhqi 116 28 - - HYPH cord-354900-bzv4yhqi 116 29 glucan glucan NN cord-354900-bzv4yhqi 116 30 to to IN cord-354900-bzv4yhqi 116 31 swine swine NN cord-354900-bzv4yhqi 116 32 influenza influenza NN cord-354900-bzv4yhqi 116 33 virus virus NN cord-354900-bzv4yhqi 116 34 by by IN cord-354900-bzv4yhqi 116 35 increased increase VBN cord-354900-bzv4yhqi 116 36 production production NN cord-354900-bzv4yhqi 116 37 of of IN cord-354900-bzv4yhqi 116 38 interferon interferon NN cord-354900-bzv4yhqi 116 39 - - HYPH cord-354900-bzv4yhqi 116 40 gamma gamma NN cord-354900-bzv4yhqi 116 41 and and CC cord-354900-bzv4yhqi 116 42 nitric nitric NN cord-354900-bzv4yhqi 116 43 oxide oxide NN cord-354900-bzv4yhqi 117 1 Beta beta JJ cord-354900-bzv4yhqi 117 2 - - HYPH cord-354900-bzv4yhqi 117 3 glucan glucan NN cord-354900-bzv4yhqi 117 4 enhancement enhancement NN cord-354900-bzv4yhqi 117 5 of of IN cord-354900-bzv4yhqi 117 6 T t NN cord-354900-bzv4yhqi 117 7 cell cell NN cord-354900-bzv4yhqi 117 8 IFNgamma IFNgamma NNP cord-354900-bzv4yhqi 117 9 response response NN cord-354900-bzv4yhqi 117 10 in in IN cord-354900-bzv4yhqi 117 11 swine swine NN cord-354900-bzv4yhqi 117 12 beta beta JJ cord-354900-bzv4yhqi 117 13 - - : cord-354900-bzv4yhqi 117 14 Glucan glucan JJ cord-354900-bzv4yhqi 117 15 derived derive VBN cord-354900-bzv4yhqi 117 16 from from IN cord-354900-bzv4yhqi 117 17 Aureobasidium Aureobasidium NNP cord-354900-bzv4yhqi 117 18 pullulans pullulan NNS cord-354900-bzv4yhqi 117 19 is be VBZ cord-354900-bzv4yhqi 117 20 effective effective JJ cord-354900-bzv4yhqi 117 21 for for IN cord-354900-bzv4yhqi 117 22 the the DT cord-354900-bzv4yhqi 117 23 prevention prevention NN cord-354900-bzv4yhqi 117 24 of of IN cord-354900-bzv4yhqi 117 25 influenza influenza NN cord-354900-bzv4yhqi 117 26 in in IN cord-354900-bzv4yhqi 117 27 mice mice NN cord-354900-bzv4yhqi 117 28 Effects effect NNS cord-354900-bzv4yhqi 117 29 of of IN cord-354900-bzv4yhqi 117 30 beta-1,3-glucan beta-1,3-glucan NNP cord-354900-bzv4yhqi 117 31 ( ( -LRB- cord-354900-bzv4yhqi 117 32 AletaTM AletaTM NNP cord-354900-bzv4yhqi 117 33 ) ) -RRB- cord-354900-bzv4yhqi 117 34 on on IN cord-354900-bzv4yhqi 117 35 vaccination vaccination NN cord-354900-bzv4yhqi 117 36 response response NN cord-354900-bzv4yhqi 117 37 in in IN cord-354900-bzv4yhqi 117 38 broiler broiler NN cord-354900-bzv4yhqi 117 39 chickens chicken NNS cord-354900-bzv4yhqi 117 40 Baker Baker NNP cord-354900-bzv4yhqi 117 41 's 's POS cord-354900-bzv4yhqi 117 42 yeast yeast NN cord-354900-bzv4yhqi 117 43 beta beta NN cord-354900-bzv4yhqi 117 44 glucan glucan JJ cord-354900-bzv4yhqi 117 45 supplementation supplementation NN cord-354900-bzv4yhqi 117 46 increases increase VBZ cord-354900-bzv4yhqi 117 47 salivary salivary NNP cord-354900-bzv4yhqi 117 48 IgA IgA NNP cord-354900-bzv4yhqi 117 49 and and CC cord-354900-bzv4yhqi 117 50 decreases decrease VBZ cord-354900-bzv4yhqi 117 51 cold cold JJ cord-354900-bzv4yhqi 117 52 / / SYM cord-354900-bzv4yhqi 117 53 flu flu NN cord-354900-bzv4yhqi 117 54 symptomatic symptomatic JJ cord-354900-bzv4yhqi 117 55 days day NNS cord-354900-bzv4yhqi 117 56 after after IN cord-354900-bzv4yhqi 117 57 intense intense JJ cord-354900-bzv4yhqi 117 58 exercise exercise NN cord-354900-bzv4yhqi 118 1 Baker Baker NNP cord-354900-bzv4yhqi 118 2 's 's POS cord-354900-bzv4yhqi 118 3 yeast yeast NN cord-354900-bzv4yhqi 118 4 beta beta NN cord-354900-bzv4yhqi 118 5 - - HYPH cord-354900-bzv4yhqi 118 6 glucan glucan NN cord-354900-bzv4yhqi 118 7 supplement supplement NN cord-354900-bzv4yhqi 118 8 reduces reduce VBZ cord-354900-bzv4yhqi 118 9 upper upper JJ cord-354900-bzv4yhqi 118 10 respiratory respiratory JJ cord-354900-bzv4yhqi 118 11 symptoms symptom NNS cord-354900-bzv4yhqi 118 12 and and CC cord-354900-bzv4yhqi 118 13 improves improve VBZ cord-354900-bzv4yhqi 118 14 mood mood NN cord-354900-bzv4yhqi 118 15 state state NN cord-354900-bzv4yhqi 118 16 in in IN cord-354900-bzv4yhqi 118 17 stressed stressed JJ cord-354900-bzv4yhqi 118 18 women woman NNS cord-354900-bzv4yhqi 118 19 Regulation regulation NN cord-354900-bzv4yhqi 118 20 of of IN cord-354900-bzv4yhqi 118 21 innate innate JJ cord-354900-bzv4yhqi 118 22 immune immune JJ cord-354900-bzv4yhqi 118 23 response response NN cord-354900-bzv4yhqi 118 24 to to IN cord-354900-bzv4yhqi 118 25 Candida Candida NNP cord-354900-bzv4yhqi 118 26 albicans albican NNS cord-354900-bzv4yhqi 118 27 infections infection NNS cord-354900-bzv4yhqi 118 28 by by IN cord-354900-bzv4yhqi 118 29 alphaMbeta2-Pra1p alphambeta2-pra1p NN cord-354900-bzv4yhqi 118 30 interaction interaction NN cord-354900-bzv4yhqi 118 31 Immune immune JJ cord-354900-bzv4yhqi 118 32 recognition recognition NN cord-354900-bzv4yhqi 118 33 of of IN cord-354900-bzv4yhqi 118 34 fungal fungal JJ cord-354900-bzv4yhqi 118 35 beta beta NN cord-354900-bzv4yhqi 118 36 - - HYPH cord-354900-bzv4yhqi 118 37 glucans glucan NNS cord-354900-bzv4yhqi 118 38 Short short JJ cord-354900-bzv4yhqi 118 39 fungal fungal JJ cord-354900-bzv4yhqi 118 40 fractions fraction NNS cord-354900-bzv4yhqi 118 41 of of IN cord-354900-bzv4yhqi 118 42 beta-1,3 beta-1,3 JJ cord-354900-bzv4yhqi 118 43 glucans glucan NNS cord-354900-bzv4yhqi 118 44 affect affect VBP cord-354900-bzv4yhqi 118 45 platelet platelet NN cord-354900-bzv4yhqi 118 46 activation activation NN cord-354900-bzv4yhqi 118 47 Clinical clinical JJ cord-354900-bzv4yhqi 118 48 characteristics characteristic NNS cord-354900-bzv4yhqi 118 49 of of IN cord-354900-bzv4yhqi 118 50 coronavirus coronavirus NN cord-354900-bzv4yhqi 118 51 disease disease NN cord-354900-bzv4yhqi 118 52 2019 2019 CD cord-354900-bzv4yhqi 118 53 in in IN cord-354900-bzv4yhqi 118 54 China China NNP cord-354900-bzv4yhqi 118 55 Anticoagulant anticoagulant JJ cord-354900-bzv4yhqi 118 56 treatment treatment NN cord-354900-bzv4yhqi 118 57 is be VBZ cord-354900-bzv4yhqi 118 58 associated associate VBN cord-354900-bzv4yhqi 118 59 with with IN cord-354900-bzv4yhqi 118 60 decreased decrease VBN cord-354900-bzv4yhqi 118 61 mortality mortality NN cord-354900-bzv4yhqi 118 62 in in IN cord-354900-bzv4yhqi 118 63 severe severe JJ cord-354900-bzv4yhqi 118 64 coronavirus coronavirus NN cord-354900-bzv4yhqi 118 65 disease disease NN cord-354900-bzv4yhqi 118 66 2019 2019 CD cord-354900-bzv4yhqi 118 67 patients patient NNS cord-354900-bzv4yhqi 118 68 with with IN cord-354900-bzv4yhqi 118 69 coagulopathy coagulopathy NN cord-354900-bzv4yhqi 118 70 ISTH isth JJ cord-354900-bzv4yhqi 118 71 interim interim JJ cord-354900-bzv4yhqi 118 72 guidance guidance NN cord-354900-bzv4yhqi 118 73 on on IN cord-354900-bzv4yhqi 118 74 recognition recognition NN cord-354900-bzv4yhqi 118 75 and and CC cord-354900-bzv4yhqi 118 76 management management NN cord-354900-bzv4yhqi 118 77 of of IN cord-354900-bzv4yhqi 118 78 coagulopathy coagulopathy NN cord-354900-bzv4yhqi 118 79 in in IN cord-354900-bzv4yhqi 118 80 COVID-19 COVID-19 NNP cord-354900-bzv4yhqi 118 81 Single single JJ cord-354900-bzv4yhqi 118 82 - - HYPH cord-354900-bzv4yhqi 118 83 cell cell NN cord-354900-bzv4yhqi 118 84 analysis analysis NN cord-354900-bzv4yhqi 118 85 of of IN cord-354900-bzv4yhqi 118 86 two two CD cord-354900-bzv4yhqi 118 87 severe severe JJ cord-354900-bzv4yhqi 118 88 COVID-19 COVID-19 NNP cord-354900-bzv4yhqi 118 89 patients patient NNS cord-354900-bzv4yhqi 118 90 reveals reveal VBZ cord-354900-bzv4yhqi 118 91 a a DT cord-354900-bzv4yhqi 118 92 monocyte monocyte NNP cord-354900-bzv4yhqi 118 93 - - HYPH cord-354900-bzv4yhqi 118 94 associated associate VBN cord-354900-bzv4yhqi 118 95 and and CC cord-354900-bzv4yhqi 118 96 tocilizumab tocilizumab NN cord-354900-bzv4yhqi 118 97 - - HYPH cord-354900-bzv4yhqi 118 98 responding respond VBG cord-354900-bzv4yhqi 118 99 cytokine cytokine NN cord-354900-bzv4yhqi 118 100 storm storm NN cord-354900-bzv4yhqi 118 101 Effects effect NNS cord-354900-bzv4yhqi 118 102 of of IN cord-354900-bzv4yhqi 118 103 10-day 10-day CD cord-354900-bzv4yhqi 118 104 confinement confinement NN cord-354900-bzv4yhqi 118 105 on on IN cord-354900-bzv4yhqi 118 106 the the DT cord-354900-bzv4yhqi 118 107 immune immune JJ cord-354900-bzv4yhqi 118 108 system system NN cord-354900-bzv4yhqi 118 109 and and CC cord-354900-bzv4yhqi 118 110 psychological psychological JJ cord-354900-bzv4yhqi 118 111 aspects aspect NNS cord-354900-bzv4yhqi 118 112 in in IN cord-354900-bzv4yhqi 118 113 humans human NNS cord-354900-bzv4yhqi 118 114 Anti anti JJ cord-354900-bzv4yhqi 118 115 - - JJ cord-354900-bzv4yhqi 118 116 stress stress JJ cord-354900-bzv4yhqi 118 117 action action NN cord-354900-bzv4yhqi 118 118 of of IN cord-354900-bzv4yhqi 118 119 several several JJ cord-354900-bzv4yhqi 118 120 orally orally RB cord-354900-bzv4yhqi 118 121 - - HYPH cord-354900-bzv4yhqi 118 122 given give VBN cord-354900-bzv4yhqi 118 123 betaglucans betaglucans NNP cord-354900-bzv4yhqi 118 124 Anti anti JJ cord-354900-bzv4yhqi 118 125 - - JJ cord-354900-bzv4yhqi 118 126 stress stress JJ cord-354900-bzv4yhqi 118 127 action action NN cord-354900-bzv4yhqi 118 128 of of IN cord-354900-bzv4yhqi 118 129 an an DT cord-354900-bzv4yhqi 118 130 orally orally RB cord-354900-bzv4yhqi 118 131 - - HYPH cord-354900-bzv4yhqi 118 132 given give VBN cord-354900-bzv4yhqi 118 133 combination combination NN cord-354900-bzv4yhqi 118 134 of of IN cord-354900-bzv4yhqi 118 135 resveratrol resveratrol NN cord-354900-bzv4yhqi 118 136 , , , cord-354900-bzv4yhqi 118 137 beta beta NN cord-354900-bzv4yhqi 118 138 - - HYPH cord-354900-bzv4yhqi 118 139 glucan glucan JJ cord-354900-bzv4yhqi 118 140 , , , cord-354900-bzv4yhqi 118 141 and and CC cord-354900-bzv4yhqi 118 142 vitamin vitamin NN cord-354900-bzv4yhqi 118 143 C c NN cord-354900-bzv4yhqi 118 144 Effects effect NNS cord-354900-bzv4yhqi 118 145 of of IN cord-354900-bzv4yhqi 118 146 glucan glucan NN cord-354900-bzv4yhqi 118 147 and and CC cord-354900-bzv4yhqi 118 148 vitamin vitamin NN cord-354900-bzv4yhqi 118 149 D d NN cord-354900-bzv4yhqi 118 150 supplementation supplementation NN cord-354900-bzv4yhqi 118 151 on on IN cord-354900-bzv4yhqi 118 152 obesity obesity NN cord-354900-bzv4yhqi 118 153 and and CC cord-354900-bzv4yhqi 118 154 lipid lipid NN cord-354900-bzv4yhqi 118 155 metabolism metabolism NN cord-354900-bzv4yhqi 118 156 in in IN cord-354900-bzv4yhqi 118 157 diabetic diabetic JJ cord-354900-bzv4yhqi 118 158 retinopathy retinopathy NN cord-354900-bzv4yhqi 118 159 Effects effect NNS cord-354900-bzv4yhqi 118 160 of of IN cord-354900-bzv4yhqi 118 161 beta beta NN cord-354900-bzv4yhqi 118 162 - - HYPH cord-354900-bzv4yhqi 118 163 glucan glucan NN cord-354900-bzv4yhqi 118 164 and and CC cord-354900-bzv4yhqi 118 165 Vitamin vitamin NN cord-354900-bzv4yhqi 118 166 D d NN cord-354900-bzv4yhqi 118 167 supplementation supplementation NN cord-354900-bzv4yhqi 118 168 on on IN cord-354900-bzv4yhqi 118 169 inflammatory inflammatory JJ cord-354900-bzv4yhqi 118 170 parameters parameter NNS cord-354900-bzv4yhqi 118 171 in in IN cord-354900-bzv4yhqi 118 172 patients patient NNS cord-354900-bzv4yhqi 118 173 with with IN cord-354900-bzv4yhqi 118 174 diabetic diabetic JJ cord-354900-bzv4yhqi 118 175 retinopathy retinopathy NN cord-354900-bzv4yhqi 118 176 Modulation modulation NN cord-354900-bzv4yhqi 118 177 of of IN cord-354900-bzv4yhqi 118 178 liver liver NN cord-354900-bzv4yhqi 118 179 fibrosis fibrosis NN cord-354900-bzv4yhqi 118 180 and and CC cord-354900-bzv4yhqi 118 181 pathophysiological pathophysiological JJ cord-354900-bzv4yhqi 118 182 changes change NNS cord-354900-bzv4yhqi 118 183 in in IN cord-354900-bzv4yhqi 118 184 mice mouse NNS cord-354900-bzv4yhqi 118 185 infected infect VBN cord-354900-bzv4yhqi 118 186 with with IN cord-354900-bzv4yhqi 118 187 Mesocestoides Mesocestoides NNP cord-354900-bzv4yhqi 118 188 corti corti NNP cord-354900-bzv4yhqi 118 189 ( ( -LRB- cord-354900-bzv4yhqi 118 190 M. M. NNP cord-354900-bzv4yhqi 118 191 vogae vogae NNP cord-354900-bzv4yhqi 118 192 ) ) -RRB- cord-354900-bzv4yhqi 118 193 after after IN cord-354900-bzv4yhqi 118 194 administration administration NN cord-354900-bzv4yhqi 118 195 of of IN cord-354900-bzv4yhqi 118 196 glucan glucan NNP cord-354900-bzv4yhqi 118 197 and and CC cord-354900-bzv4yhqi 118 198 liposomized liposomized JJ cord-354900-bzv4yhqi 118 199 glucan glucan NN cord-354900-bzv4yhqi 118 200 in in IN cord-354900-bzv4yhqi 118 201 combination combination NN cord-354900-bzv4yhqi 118 202 with with IN cord-354900-bzv4yhqi 118 203 vitamin vitamin NN cord-354900-bzv4yhqi 118 204 C C NNP cord-354900-bzv4yhqi 118 205 Combination Combination NNP cord-354900-bzv4yhqi 118 206 of of IN cord-354900-bzv4yhqi 118 207 glucan glucan NN cord-354900-bzv4yhqi 118 208 , , , cord-354900-bzv4yhqi 118 209 resveratrol resveratrol NN cord-354900-bzv4yhqi 118 210 and and CC cord-354900-bzv4yhqi 118 211 vitamin vitamin NN cord-354900-bzv4yhqi 118 212 C C NNP cord-354900-bzv4yhqi 118 213 demonstrates demonstrate VBZ cord-354900-bzv4yhqi 118 214 strong strong JJ cord-354900-bzv4yhqi 118 215 anti anti JJ cord-354900-bzv4yhqi 118 216 - - JJ cord-354900-bzv4yhqi 118 217 tumor tumor JJ cord-354900-bzv4yhqi 118 218 potential potential JJ cord-354900-bzv4yhqi 118 219 Synergistic synergistic JJ cord-354900-bzv4yhqi 118 220 potentiation potentiation NN cord-354900-bzv4yhqi 118 221 of of IN cord-354900-bzv4yhqi 118 222 D d NN cord-354900-bzv4yhqi 118 223 - - HYPH cord-354900-bzv4yhqi 118 224 fraction fraction NN cord-354900-bzv4yhqi 118 225 with with IN cord-354900-bzv4yhqi 118 226 vitamin vitamin NN cord-354900-bzv4yhqi 118 227 C c NN cord-354900-bzv4yhqi 118 228 as as IN cord-354900-bzv4yhqi 118 229 possible possible JJ cord-354900-bzv4yhqi 118 230 alternative alternative JJ cord-354900-bzv4yhqi 118 231 approach approach NN cord-354900-bzv4yhqi 118 232 for for IN cord-354900-bzv4yhqi 118 233 cancer cancer NN cord-354900-bzv4yhqi 118 234 therapy therapy NN cord-354900-bzv4yhqi 118 235 Randomized randomized JJ cord-354900-bzv4yhqi 118 236 trial trial NN cord-354900-bzv4yhqi 118 237 of of IN cord-354900-bzv4yhqi 118 238 vitamin vitamin NN cord-354900-bzv4yhqi 118 239 D d NN cord-354900-bzv4yhqi 118 240 supplementation supplementation NN cord-354900-bzv4yhqi 118 241 to to TO cord-354900-bzv4yhqi 118 242 prevent prevent VB cord-354900-bzv4yhqi 118 243 seasonal seasonal JJ cord-354900-bzv4yhqi 118 244 influenza influenza NN cord-354900-bzv4yhqi 118 245 A a NN cord-354900-bzv4yhqi 118 246 in in IN cord-354900-bzv4yhqi 118 247 schoolchildren schoolchildren NNS cord-354900-bzv4yhqi 118 248 Epidemic epidemic NN cord-354900-bzv4yhqi 118 249 influenza influenza NN cord-354900-bzv4yhqi 118 250 and and CC cord-354900-bzv4yhqi 118 251 vitamin vitamin NN cord-354900-bzv4yhqi 118 252 D d NN cord-354900-bzv4yhqi 118 253 Vitamin vitamin NN cord-354900-bzv4yhqi 118 254 D d NN cord-354900-bzv4yhqi 118 255 decreases decrease VBZ cord-354900-bzv4yhqi 118 256 respiratory respiratory JJ cord-354900-bzv4yhqi 118 257 syncytial syncytial JJ cord-354900-bzv4yhqi 118 258 virus virus NN cord-354900-bzv4yhqi 118 259 induction induction NN cord-354900-bzv4yhqi 118 260 of of IN cord-354900-bzv4yhqi 118 261 NF nf NN cord-354900-bzv4yhqi 118 262 - - HYPH cord-354900-bzv4yhqi 118 263 kappaBlinked kappablinke VBN cord-354900-bzv4yhqi 118 264 chemokines chemokine NNS cord-354900-bzv4yhqi 118 265 and and CC cord-354900-bzv4yhqi 118 266 cytokines cytokine NNS cord-354900-bzv4yhqi 118 267 in in IN cord-354900-bzv4yhqi 118 268 airway airway NN cord-354900-bzv4yhqi 118 269 epithelium epithelium NN cord-354900-bzv4yhqi 118 270 while while IN cord-354900-bzv4yhqi 118 271 maintaining maintain VBG cord-354900-bzv4yhqi 118 272 the the DT cord-354900-bzv4yhqi 118 273 antiviral antiviral JJ cord-354900-bzv4yhqi 118 274 state state NN cord-354900-bzv4yhqi 118 275 Hypovitaminosis Hypovitaminosis NNP cord-354900-bzv4yhqi 118 276 C C NNP cord-354900-bzv4yhqi 118 277 and and CC cord-354900-bzv4yhqi 118 278 vitamin vitamin NN cord-354900-bzv4yhqi 118 279 C C NNP cord-354900-bzv4yhqi 118 280 deficiency deficiency NN cord-354900-bzv4yhqi 118 281 in in IN cord-354900-bzv4yhqi 118 282 critically critically RB cord-354900-bzv4yhqi 118 283 ill ill JJ cord-354900-bzv4yhqi 118 284 patients patient NNS cord-354900-bzv4yhqi 118 285 despite despite IN cord-354900-bzv4yhqi 118 286 recommended recommend VBN cord-354900-bzv4yhqi 118 287 enteral enteral NN cord-354900-bzv4yhqi 118 288 and and CC cord-354900-bzv4yhqi 118 289 parenteral parenteral JJ cord-354900-bzv4yhqi 118 290 intakes intake NNS cord-354900-bzv4yhqi 119 1 The the DT cord-354900-bzv4yhqi 119 2 effectiveness effectiveness NN cord-354900-bzv4yhqi 119 3 of of IN cord-354900-bzv4yhqi 119 4 vitamin vitamin NN cord-354900-bzv4yhqi 119 5 C c NN cord-354900-bzv4yhqi 119 6 in in IN cord-354900-bzv4yhqi 119 7 preventing prevent VBG cord-354900-bzv4yhqi 119 8 and and CC cord-354900-bzv4yhqi 119 9 relieving relieve VBG cord-354900-bzv4yhqi 119 10 the the DT cord-354900-bzv4yhqi 119 11 symptoms symptom NNS cord-354900-bzv4yhqi 119 12 of of IN cord-354900-bzv4yhqi 119 13 virus virus NN cord-354900-bzv4yhqi 119 14 - - HYPH cord-354900-bzv4yhqi 119 15 induced induce VBN cord-354900-bzv4yhqi 119 16 respiratory respiratory JJ cord-354900-bzv4yhqi 119 17 infections infection NNS cord-354900-bzv4yhqi 119 18 Antiviral antiviral JJ cord-354900-bzv4yhqi 119 19 effect effect NN cord-354900-bzv4yhqi 119 20 of of IN cord-354900-bzv4yhqi 119 21 flavonoids flavonoid NNS cord-354900-bzv4yhqi 119 22 on on IN cord-354900-bzv4yhqi 119 23 human human JJ cord-354900-bzv4yhqi 119 24 viruses virus NNS cord-354900-bzv4yhqi 119 25 Effect effect NN cord-354900-bzv4yhqi 119 26 of of IN cord-354900-bzv4yhqi 119 27 increasing increase VBG cord-354900-bzv4yhqi 119 28 fruit fruit NN cord-354900-bzv4yhqi 119 29 and and CC cord-354900-bzv4yhqi 119 30 vegetable vegetable NN cord-354900-bzv4yhqi 119 31 intake intake NN cord-354900-bzv4yhqi 119 32 by by IN cord-354900-bzv4yhqi 119 33 dietary dietary JJ cord-354900-bzv4yhqi 119 34 intervention intervention NN cord-354900-bzv4yhqi 119 35 on on IN cord-354900-bzv4yhqi 119 36 nutritional nutritional JJ cord-354900-bzv4yhqi 119 37 biomarkers biomarker NNS cord-354900-bzv4yhqi 119 38 and and CC cord-354900-bzv4yhqi 119 39 attitudes attitude NNS cord-354900-bzv4yhqi 119 40 to to IN cord-354900-bzv4yhqi 119 41 dietary dietary JJ cord-354900-bzv4yhqi 119 42 change change NN cord-354900-bzv4yhqi 119 43 : : : cord-354900-bzv4yhqi 119 44 a a DT cord-354900-bzv4yhqi 119 45 randomised randomised JJ cord-354900-bzv4yhqi 119 46 trial trial NN cord-354900-bzv4yhqi 119 47 Roles role NNS cord-354900-bzv4yhqi 119 48 of of IN cord-354900-bzv4yhqi 119 49 flavonoids flavonoid NNS cord-354900-bzv4yhqi 119 50 against against IN cord-354900-bzv4yhqi 119 51 coronavirus coronavirus NN cord-354900-bzv4yhqi 119 52 infection infection NN cord-354900-bzv4yhqi 120 1 Early early JJ cord-354900-bzv4yhqi 120 2 nutritional nutritional JJ cord-354900-bzv4yhqi 120 3 supplementation supplementation NN cord-354900-bzv4yhqi 120 4 in in IN cord-354900-bzv4yhqi 120 5 non non JJ cord-354900-bzv4yhqi 120 6 - - JJ cord-354900-bzv4yhqi 120 7 critically critically RB cord-354900-bzv4yhqi 120 8 ill ill JJ cord-354900-bzv4yhqi 120 9 patients patient NNS cord-354900-bzv4yhqi 120 10 hospitalized hospitalize VBN cord-354900-bzv4yhqi 120 11 for for IN cord-354900-bzv4yhqi 120 12 the the DT cord-354900-bzv4yhqi 120 13 , , , cord-354900-bzv4yhqi 120 14 2019 2019 CD cord-354900-bzv4yhqi 120 15 novel novel JJ cord-354900-bzv4yhqi 120 16 coronavirus coronavirus NN cord-354900-bzv4yhqi 120 17 disease disease NN cord-354900-bzv4yhqi 120 18 ( ( -LRB- cord-354900-bzv4yhqi 120 19 COVID-19 COVID-19 NNP cord-354900-bzv4yhqi 120 20 ) ) -RRB- cord-354900-bzv4yhqi 120 21 : : : cord-354900-bzv4yhqi 121 1 rationale rationale NN cord-354900-bzv4yhqi 121 2 and and CC cord-354900-bzv4yhqi 121 3 feasibility feasibility NN cord-354900-bzv4yhqi 121 4 of of IN cord-354900-bzv4yhqi 121 5 a a DT cord-354900-bzv4yhqi 121 6 shared share VBN cord-354900-bzv4yhqi 121 7 pragmatic pragmatic JJ cord-354900-bzv4yhqi 121 8 protocol protocol NN cord-354900-bzv4yhqi 121 9 Effect effect NN cord-354900-bzv4yhqi 121 10 of of IN cord-354900-bzv4yhqi 121 11 single single JJ cord-354900-bzv4yhqi 121 12 - - HYPH cord-354900-bzv4yhqi 121 13 dose dose NN cord-354900-bzv4yhqi 121 14 injection injection NN cord-354900-bzv4yhqi 121 15 of of IN cord-354900-bzv4yhqi 121 16 vitamin vitamin NN cord-354900-bzv4yhqi 121 17 D d NN cord-354900-bzv4yhqi 121 18 on on IN cord-354900-bzv4yhqi 121 19 immune immune JJ cord-354900-bzv4yhqi 121 20 cytokines cytokine NNS cord-354900-bzv4yhqi 121 21 in in IN cord-354900-bzv4yhqi 121 22 ulcerative ulcerative JJ cord-354900-bzv4yhqi 121 23 colitis colitis NN cord-354900-bzv4yhqi 121 24 patients patient NNS cord-354900-bzv4yhqi 121 25 : : : cord-354900-bzv4yhqi 121 26 a a DT cord-354900-bzv4yhqi 121 27 randomized randomized JJ cord-354900-bzv4yhqi 121 28 placebo placebo NN cord-354900-bzv4yhqi 121 29 - - HYPH cord-354900-bzv4yhqi 121 30 controlled control VBN cord-354900-bzv4yhqi 121 31 trial trial NN cord-354900-bzv4yhqi 121 32 Regulation regulation NN cord-354900-bzv4yhqi 121 33 of of IN cord-354900-bzv4yhqi 121 34 cytokine cytokine JJ cord-354900-bzv4yhqi 121 35 responses response NNS cord-354900-bzv4yhqi 121 36 by by IN cord-354900-bzv4yhqi 121 37 seasonality seasonality NN cord-354900-bzv4yhqi 121 38 of of IN cord-354900-bzv4yhqi 121 39 vitamin vitamin NN cord-354900-bzv4yhqi 121 40 D d NN cord-354900-bzv4yhqi 121 41 status status NN cord-354900-bzv4yhqi 121 42 in in IN cord-354900-bzv4yhqi 121 43 healthy healthy JJ cord-354900-bzv4yhqi 121 44 individuals individual NNS cord-354900-bzv4yhqi 121 45 Evidence evidence NN cord-354900-bzv4yhqi 121 46 that that IN cord-354900-bzv4yhqi 121 47 Vitamin vitamin NN cord-354900-bzv4yhqi 121 48 D d NN cord-354900-bzv4yhqi 121 49 supplementation supplementation NN cord-354900-bzv4yhqi 121 50 could could MD cord-354900-bzv4yhqi 121 51 reduce reduce VB cord-354900-bzv4yhqi 121 52 risk risk NN cord-354900-bzv4yhqi 121 53 of of IN cord-354900-bzv4yhqi 121 54 influenza influenza NN cord-354900-bzv4yhqi 121 55 and and CC cord-354900-bzv4yhqi 121 56 COVID-19 covid-19 JJ cord-354900-bzv4yhqi 121 57 infections infection NNS cord-354900-bzv4yhqi 121 58 and and CC cord-354900-bzv4yhqi 121 59 deaths death NNS cord-354900-bzv4yhqi 121 60 Vitamin vitamin NN cord-354900-bzv4yhqi 121 61 D d NN cord-354900-bzv4yhqi 121 62 insufficiency insufficiency NN cord-354900-bzv4yhqi 121 63 as as IN cord-354900-bzv4yhqi 121 64 a a DT cord-354900-bzv4yhqi 121 65 potential potential JJ cord-354900-bzv4yhqi 121 66 culprit culprit NN cord-354900-bzv4yhqi 121 67 in in IN cord-354900-bzv4yhqi 121 68 critical critical JJ cord-354900-bzv4yhqi 121 69 COVID-19 COVID-19 NNP cord-354900-bzv4yhqi 121 70 patients patient NNS cord-354900-bzv4yhqi 121 71 A a DT cord-354900-bzv4yhqi 121 72 new new JJ cord-354900-bzv4yhqi 121 73 clinical clinical JJ cord-354900-bzv4yhqi 121 74 trial trial NN cord-354900-bzv4yhqi 121 75 to to TO cord-354900-bzv4yhqi 121 76 test test VB cord-354900-bzv4yhqi 121 77 high high JJ cord-354900-bzv4yhqi 121 78 - - HYPH cord-354900-bzv4yhqi 121 79 dose dose NN cord-354900-bzv4yhqi 121 80 vitamin vitamin NN cord-354900-bzv4yhqi 121 81 C c NN cord-354900-bzv4yhqi 121 82 in in IN cord-354900-bzv4yhqi 121 83 patients patient NNS cord-354900-bzv4yhqi 121 84 with with IN cord-354900-bzv4yhqi 121 85 COVID-19 COVID-19 NNP cord-354900-bzv4yhqi 121 86 Protective protective JJ cord-354900-bzv4yhqi 121 87 role role NN cord-354900-bzv4yhqi 121 88 of of IN cord-354900-bzv4yhqi 121 89 1,25(OH)2 1,25(oh)2 JJ cord-354900-bzv4yhqi 121 90 vitamin vitamin NN cord-354900-bzv4yhqi 121 91 D3 D3 NNP cord-354900-bzv4yhqi 121 92 in in IN cord-354900-bzv4yhqi 121 93 the the DT cord-354900-bzv4yhqi 121 94 mucosal mucosal JJ cord-354900-bzv4yhqi 121 95 injury injury NN cord-354900-bzv4yhqi 121 96 and and CC cord-354900-bzv4yhqi 121 97 epithelial epithelial JJ cord-354900-bzv4yhqi 121 98 barrier barrier NN cord-354900-bzv4yhqi 121 99 disruption disruption NN cord-354900-bzv4yhqi 121 100 in in IN cord-354900-bzv4yhqi 121 101 DSS DSS NNP cord-354900-bzv4yhqi 121 102 - - HYPH cord-354900-bzv4yhqi 121 103 induced induce VBN cord-354900-bzv4yhqi 121 104 acute acute JJ cord-354900-bzv4yhqi 121 105 colitis colitis NN cord-354900-bzv4yhqi 121 106 in in IN cord-354900-bzv4yhqi 121 107 mice mice NN cord-354900-bzv4yhqi 121 108 Diet Diet NNP cord-354900-bzv4yhqi 121 109 - - HYPH cord-354900-bzv4yhqi 121 110 induced induce VBN cord-354900-bzv4yhqi 121 111 obesity obesity NN cord-354900-bzv4yhqi 121 112 is be VBZ cord-354900-bzv4yhqi 121 113 linked link VBN cord-354900-bzv4yhqi 121 114 to to IN cord-354900-bzv4yhqi 121 115 marked marked JJ cord-354900-bzv4yhqi 121 116 but but CC cord-354900-bzv4yhqi 121 117 reversible reversible JJ cord-354900-bzv4yhqi 121 118 alterations alteration NNS cord-354900-bzv4yhqi 121 119 in in IN cord-354900-bzv4yhqi 121 120 the the DT cord-354900-bzv4yhqi 121 121 mouse mouse NN cord-354900-bzv4yhqi 121 122 distal distal JJ cord-354900-bzv4yhqi 121 123 gut gut NN cord-354900-bzv4yhqi 121 124 microbiome microbiome NN cord-354900-bzv4yhqi 121 125 Evidence evidence NN cord-354900-bzv4yhqi 121 126 that that IN cord-354900-bzv4yhqi 121 127 asthma asthma NN cord-354900-bzv4yhqi 121 128 is be VBZ cord-354900-bzv4yhqi 121 129 a a DT cord-354900-bzv4yhqi 121 130 developmental developmental JJ cord-354900-bzv4yhqi 121 131 origin origin NN cord-354900-bzv4yhqi 121 132 disease disease NN cord-354900-bzv4yhqi 121 133 influenced influence VBN cord-354900-bzv4yhqi 121 134 by by IN cord-354900-bzv4yhqi 121 135 maternal maternal JJ cord-354900-bzv4yhqi 121 136 diet diet NN cord-354900-bzv4yhqi 121 137 and and CC cord-354900-bzv4yhqi 121 138 bacterial bacterial JJ cord-354900-bzv4yhqi 121 139 metabolites metabolite NNS cord-354900-bzv4yhqi 122 1 Antiinfluenza Antiinfluenza NNP cord-354900-bzv4yhqi 122 2 virus virus NN cord-354900-bzv4yhqi 122 3 effects effect NNS cord-354900-bzv4yhqi 122 4 of of IN cord-354900-bzv4yhqi 122 5 both both DT cord-354900-bzv4yhqi 122 6 live live JJ cord-354900-bzv4yhqi 122 7 and and CC cord-354900-bzv4yhqi 122 8 non non JJ cord-354900-bzv4yhqi 122 9 - - JJ cord-354900-bzv4yhqi 122 10 live live JJ cord-354900-bzv4yhqi 122 11 Lactobacillus lactobacillus NN cord-354900-bzv4yhqi 122 12 acidophilus acidophilus NN cord-354900-bzv4yhqi 122 13 L-92 L-92 NNP cord-354900-bzv4yhqi 122 14 accompanied accompany VBN cord-354900-bzv4yhqi 122 15 by by IN cord-354900-bzv4yhqi 122 16 the the DT cord-354900-bzv4yhqi 122 17 activation activation NN cord-354900-bzv4yhqi 122 18 of of IN cord-354900-bzv4yhqi 122 19 innate innate JJ cord-354900-bzv4yhqi 122 20 immunity immunity NN cord-354900-bzv4yhqi 122 21 The the DT cord-354900-bzv4yhqi 122 22 gut gut NN cord-354900-bzv4yhqi 122 23 - - HYPH cord-354900-bzv4yhqi 122 24 lung lung NN cord-354900-bzv4yhqi 122 25 axis axis NN cord-354900-bzv4yhqi 122 26 in in IN cord-354900-bzv4yhqi 122 27 respiratory respiratory JJ cord-354900-bzv4yhqi 122 28 disease disease NN cord-354900-bzv4yhqi 122 29 Influenza Influenza NNP cord-354900-bzv4yhqi 122 30 virus virus NN cord-354900-bzv4yhqi 122 31 affects affect VBZ cord-354900-bzv4yhqi 122 32 intestinal intestinal JJ cord-354900-bzv4yhqi 122 33 microbiota microbiota NN cord-354900-bzv4yhqi 122 34 and and CC cord-354900-bzv4yhqi 122 35 secondary secondary JJ cord-354900-bzv4yhqi 122 36 Salmonella Salmonella NNP cord-354900-bzv4yhqi 122 37 infection infection NN cord-354900-bzv4yhqi 122 38 in in IN cord-354900-bzv4yhqi 122 39 the the DT cord-354900-bzv4yhqi 122 40 gut gut NN cord-354900-bzv4yhqi 122 41 through through IN cord-354900-bzv4yhqi 122 42 type type NN cord-354900-bzv4yhqi 122 43 I -PRON- PRP cord-354900-bzv4yhqi 122 44 interferons interferons NNPS cord-354900-bzv4yhqi 122 45 Management Management NNP cord-354900-bzv4yhqi 122 46 of of IN cord-354900-bzv4yhqi 122 47 corona corona NNP cord-354900-bzv4yhqi 122 48 virus virus NN cord-354900-bzv4yhqi 122 49 disease-19 disease-19 NNP cord-354900-bzv4yhqi 122 50 ( ( -LRB- cord-354900-bzv4yhqi 122 51 COVID-19 COVID-19 NNP cord-354900-bzv4yhqi 122 52 ) ) -RRB- cord-354900-bzv4yhqi 122 53 : : : cord-354900-bzv4yhqi 122 54 the the DT cord-354900-bzv4yhqi 122 55 Zhejiang Zhejiang NNP cord-354900-bzv4yhqi 122 56 experience experience NN cord-354900-bzv4yhqi 122 57 . . . cord-354900-bzv4yhqi 123 1 Zhejiang Zhejiang NNP cord-354900-bzv4yhqi 123 2 Da Da NNP cord-354900-bzv4yhqi 123 3 Xue Xue NNP cord-354900-bzv4yhqi 124 1 Xue Xue NNP cord-354900-bzv4yhqi 124 2 Bao Bao NNP cord-354900-bzv4yhqi 124 3 Yi Yi NNP cord-354900-bzv4yhqi 124 4 Xue Xue NNP cord-354900-bzv4yhqi 125 1 Ban Ban NNP cord-354900-bzv4yhqi 125 2 Publisher Publisher NNP cord-354900-bzv4yhqi 125 3 's 's POS cord-354900-bzv4yhqi 125 4 Note Note NNP cord-354900-bzv4yhqi 125 5 Springer Springer NNP cord-354900-bzv4yhqi 125 6 Nature Nature NNP cord-354900-bzv4yhqi 125 7 remains remain VBZ cord-354900-bzv4yhqi 125 8 neutral neutral JJ cord-354900-bzv4yhqi 125 9 with with IN cord-354900-bzv4yhqi 125 10 regard regard NN cord-354900-bzv4yhqi 125 11 to to IN cord-354900-bzv4yhqi 125 12 jurisdictional jurisdictional JJ cord-354900-bzv4yhqi 125 13 claims claim NNS cord-354900-bzv4yhqi 125 14 in in IN cord-354900-bzv4yhqi 125 15 published publish VBN cord-354900-bzv4yhqi 125 16 maps map NNS cord-354900-bzv4yhqi 125 17 and and CC cord-354900-bzv4yhqi 125 18 institutional institutional JJ cord-354900-bzv4yhqi 125 19 affiliations affiliation NNS cord-354900-bzv4yhqi 125 20 Not not RB cord-354900-bzv4yhqi 125 21 applicable applicable JJ cord-354900-bzv4yhqi 125 22 . . . cord-354900-bzv4yhqi 126 1 SJ SJ NNP cord-354900-bzv4yhqi 126 2 drafted draft VBD cord-354900-bzv4yhqi 126 3 this this DT cord-354900-bzv4yhqi 126 4 review review NN cord-354900-bzv4yhqi 126 5 . . . cord-354900-bzv4yhqi 127 1 The the DT cord-354900-bzv4yhqi 127 2 author author NN cord-354900-bzv4yhqi 127 3 read read VBD cord-354900-bzv4yhqi 127 4 and and CC cord-354900-bzv4yhqi 127 5 approved approve VBD cord-354900-bzv4yhqi 127 6 the the DT cord-354900-bzv4yhqi 127 7 final final JJ cord-354900-bzv4yhqi 127 8 manuscript manuscript NN cord-354900-bzv4yhqi 127 9 . . . cord-354900-bzv4yhqi 128 1 This this DT cord-354900-bzv4yhqi 128 2 work work NN cord-354900-bzv4yhqi 128 3 was be VBD cord-354900-bzv4yhqi 128 4 partially partially RB cord-354900-bzv4yhqi 128 5 funded fund VBN cord-354900-bzv4yhqi 128 6 by by IN cord-354900-bzv4yhqi 128 7 the the DT cord-354900-bzv4yhqi 128 8 Agence Agence NNP cord-354900-bzv4yhqi 128 9 Nationale Nationale NNP cord-354900-bzv4yhqi 128 10 de de NNP cord-354900-bzv4yhqi 128 11 la la FW cord-354900-bzv4yhqi 128 12 Recherche Recherche NNP cord-354900-bzv4yhqi 128 13 ( ( -LRB- cord-354900-bzv4yhqi 128 14 ANR ANR NNP cord-354900-bzv4yhqi 128 15 ) ) -RRB- cord-354900-bzv4yhqi 128 16 in in IN cord-354900-bzv4yhqi 128 17 the the DT cord-354900-bzv4yhqi 128 18 setting setting NN cord-354900-bzv4yhqi 128 19 of of IN cord-354900-bzv4yhqi 128 20 project project NN cord-354900-bzv4yhqi 128 21 " " '' cord-354900-bzv4yhqi 128 22 InnateFun InnateFun NNP cord-354900-bzv4yhqi 128 23 " " '' cord-354900-bzv4yhqi 128 24 , , , cord-354900-bzv4yhqi 128 25 promotional promotional JJ cord-354900-bzv4yhqi 128 26 reference reference NN cord-354900-bzv4yhqi 128 27 ANR-16-IFEC-0003 ANR-16-IFEC-0003 NNP cord-354900-bzv4yhqi 128 28 - - HYPH cord-354900-bzv4yhqi 128 29 05 05 CD cord-354900-bzv4yhqi 128 30 , , , cord-354900-bzv4yhqi 128 31 in in IN cord-354900-bzv4yhqi 128 32 the the DT cord-354900-bzv4yhqi 128 33 " " `` cord-354900-bzv4yhqi 128 34 Infect infect VB cord-354900-bzv4yhqi 128 35 - - HYPH cord-354900-bzv4yhqi 128 36 ERA era NN cord-354900-bzv4yhqi 128 37 " " '' cord-354900-bzv4yhqi 128 38 program program NN cord-354900-bzv4yhqi 128 39 . . .