id sid tid token lemma pos cord-354168-omen8vvq 1 1 key key NN cord-354168-omen8vvq 1 2 : : : cord-354168-omen8vvq 2 1 cord-354168-omen8vvq cord-354168-omen8vvq NNP cord-354168-omen8vvq 2 2 authors author NNS cord-354168-omen8vvq 2 3 : : : cord-354168-omen8vvq 2 4 Al Al NNP cord-354168-omen8vvq 2 5 Saleh Saleh NNP cord-354168-omen8vvq 2 6 , , , cord-354168-omen8vvq 2 7 Abdullah Abdullah NNP cord-354168-omen8vvq 2 8 S. S. NNP cord-354168-omen8vvq 2 9 ; ; : cord-354168-omen8vvq 2 10 Sher Sher NNP cord-354168-omen8vvq 2 11 , , , cord-354168-omen8vvq 2 12 Taimur Taimur NNP cord-354168-omen8vvq 2 13 ; ; : cord-354168-omen8vvq 2 14 Gertz Gertz NNP cord-354168-omen8vvq 2 15 , , , cord-354168-omen8vvq 2 16 Morie Morie NNP cord-354168-omen8vvq 2 17 A. a. NN cord-354168-omen8vvq 2 18 title title NN cord-354168-omen8vvq 2 19 : : : cord-354168-omen8vvq 2 20 Multiple multiple JJ cord-354168-omen8vvq 2 21 Myeloma Myeloma NNP cord-354168-omen8vvq 2 22 in in IN cord-354168-omen8vvq 2 23 the the DT cord-354168-omen8vvq 2 24 Time Time NNP cord-354168-omen8vvq 2 25 of of IN cord-354168-omen8vvq 2 26 COVID-19 COVID-19 NNP cord-354168-omen8vvq 2 27 date date NN cord-354168-omen8vvq 2 28 : : : cord-354168-omen8vvq 2 29 2020 2020 CD cord-354168-omen8vvq 2 30 - - HYPH cord-354168-omen8vvq 2 31 04 04 CD cord-354168-omen8vvq 2 32 - - SYM cord-354168-omen8vvq 2 33 17 17 CD cord-354168-omen8vvq 2 34 journal journal NN cord-354168-omen8vvq 2 35 : : : cord-354168-omen8vvq 2 36 Acta Acta NNP cord-354168-omen8vvq 2 37 Haematol Haematol NNP cord-354168-omen8vvq 2 38 DOI DOI NNP cord-354168-omen8vvq 2 39 : : : cord-354168-omen8vvq 2 40 10.1159/000507690 10.1159/000507690 CD cord-354168-omen8vvq 2 41 sha sha NNP cord-354168-omen8vvq 2 42 : : : cord-354168-omen8vvq 3 1 b868b97fd167fb8c771dc669e1a0de86d546209d b868b97fd167fb8c771dc669e1a0de86d546209d NNP cord-354168-omen8vvq 3 2 doc_id doc_id NNP cord-354168-omen8vvq 3 3 : : : cord-354168-omen8vvq 3 4 354168 354168 CD cord-354168-omen8vvq 3 5 cord_uid cord_uid NNS cord-354168-omen8vvq 3 6 : : : cord-354168-omen8vvq 4 1 omen8vvq omen8vvq NNP cord-354168-omen8vvq 5 1 We -PRON- PRP cord-354168-omen8vvq 5 2 provide provide VBP cord-354168-omen8vvq 5 3 our -PRON- PRP$ cord-354168-omen8vvq 5 4 recommendations recommendation NNS cord-354168-omen8vvq 5 5 ( ( -LRB- cord-354168-omen8vvq 5 6 not not RB cord-354168-omen8vvq 5 7 evidence evidence NN cord-354168-omen8vvq 5 8 based base VBN cord-354168-omen8vvq 5 9 ) ) -RRB- cord-354168-omen8vvq 5 10 for for IN cord-354168-omen8vvq 5 11 managing manage VBG cord-354168-omen8vvq 5 12 multiple multiple JJ cord-354168-omen8vvq 5 13 myeloma myeloma NN cord-354168-omen8vvq 5 14 patients patient NNS cord-354168-omen8vvq 5 15 during during IN cord-354168-omen8vvq 5 16 the the DT cord-354168-omen8vvq 5 17 pandemic pandemic NN cord-354168-omen8vvq 5 18 of of IN cord-354168-omen8vvq 5 19 COVID-19 COVID-19 NNP cord-354168-omen8vvq 5 20 . . . cord-354168-omen8vvq 6 1 We -PRON- PRP cord-354168-omen8vvq 6 2 do do VBP cord-354168-omen8vvq 6 3 not not RB cord-354168-omen8vvq 6 4 recommend recommend VB cord-354168-omen8vvq 6 5 therapy therapy NN cord-354168-omen8vvq 6 6 for for IN cord-354168-omen8vvq 6 7 smoldering smolder VBG cord-354168-omen8vvq 6 8 myeloma myeloma NN cord-354168-omen8vvq 6 9 patients patient NNS cord-354168-omen8vvq 6 10 ( ( -LRB- cord-354168-omen8vvq 6 11 standard standard JJ cord-354168-omen8vvq 6 12 or or CC cord-354168-omen8vvq 6 13 high high JJ cord-354168-omen8vvq 6 14 risk risk NN cord-354168-omen8vvq 6 15 ) ) -RRB- cord-354168-omen8vvq 6 16 . . . cord-354168-omen8vvq 7 1 Screening screen VBG cord-354168-omen8vvq 7 2 for for IN cord-354168-omen8vvq 7 3 COVID-19 COVID-19 NNP cord-354168-omen8vvq 7 4 should should MD cord-354168-omen8vvq 7 5 be be VB cord-354168-omen8vvq 7 6 done do VBN cord-354168-omen8vvq 7 7 in in IN cord-354168-omen8vvq 7 8 all all DT cord-354168-omen8vvq 7 9 patients patient NNS cord-354168-omen8vvq 7 10 before before IN cord-354168-omen8vvq 7 11 therapy therapy NN cord-354168-omen8vvq 7 12 . . . cord-354168-omen8vvq 8 1 For for IN cord-354168-omen8vvq 8 2 standard standard JJ cord-354168-omen8vvq 8 3 - - HYPH cord-354168-omen8vvq 8 4 risk risk NN cord-354168-omen8vvq 8 5 patients patient NNS cord-354168-omen8vvq 8 6 , , , cord-354168-omen8vvq 8 7 we -PRON- PRP cord-354168-omen8vvq 8 8 recommend recommend VBP cord-354168-omen8vvq 8 9 the the DT cord-354168-omen8vvq 8 10 following follow VBG cord-354168-omen8vvq 8 11 : : : cord-354168-omen8vvq 8 12 ixazomib ixazomib NNP cord-354168-omen8vvq 8 13 , , , cord-354168-omen8vvq 8 14 lenalidomide lenalidomide NN cord-354168-omen8vvq 8 15 , , , cord-354168-omen8vvq 8 16 and and CC cord-354168-omen8vvq 8 17 dexamethasone dexamethasone NN cord-354168-omen8vvq 8 18 ( ( -LRB- cord-354168-omen8vvq 8 19 IRd IRd NNP cord-354168-omen8vvq 8 20 ) ) -RRB- cord-354168-omen8vvq 8 21 ( ( -LRB- cord-354168-omen8vvq 8 22 preferred prefer VBN cord-354168-omen8vvq 8 23 ) ) -RRB- cord-354168-omen8vvq 8 24 , , , cord-354168-omen8vvq 8 25 cyclophosphamide cyclophosphamide IN cord-354168-omen8vvq 8 26 lenalidomide lenalidomide NN cord-354168-omen8vvq 8 27 and and CC cord-354168-omen8vvq 8 28 dexamethasone dexamethasone NN cord-354168-omen8vvq 8 29 ( ( -LRB- cord-354168-omen8vvq 8 30 CRd CRd NNP cord-354168-omen8vvq 8 31 ) ) -RRB- cord-354168-omen8vvq 8 32 , , , cord-354168-omen8vvq 8 33 daratumumab daratumumab VBD cord-354168-omen8vvq 8 34 lenalidomide lenalidomide NN cord-354168-omen8vvq 8 35 and and CC cord-354168-omen8vvq 8 36 dexamethasone dexamethasone NN cord-354168-omen8vvq 8 37 ( ( -LRB- cord-354168-omen8vvq 8 38 DRd DRd NNS cord-354168-omen8vvq 8 39 ) ) -RRB- cord-354168-omen8vvq 8 40 , , , cord-354168-omen8vvq 8 41 lenalidomide lenalidomide NN cord-354168-omen8vvq 8 42 , , , cord-354168-omen8vvq 8 43 bortezomib bortezomib NNP cord-354168-omen8vvq 8 44 , , , cord-354168-omen8vvq 8 45 and and CC cord-354168-omen8vvq 8 46 dexamethasone dexamethasone NN cord-354168-omen8vvq 8 47 ( ( -LRB- cord-354168-omen8vvq 8 48 RVd rvd NN cord-354168-omen8vvq 8 49 ) ) -RRB- cord-354168-omen8vvq 8 50 , , , cord-354168-omen8vvq 8 51 or or CC cord-354168-omen8vvq 8 52 cyclophosphamide cyclophosphamide NN cord-354168-omen8vvq 8 53 , , , cord-354168-omen8vvq 8 54 bortezomib bortezomib NNP cord-354168-omen8vvq 8 55 , , , cord-354168-omen8vvq 8 56 and and CC cord-354168-omen8vvq 8 57 dexamethasone dexamethasone NN cord-354168-omen8vvq 8 58 ( ( -LRB- cord-354168-omen8vvq 8 59 CyBorD CyBorD NNP cord-354168-omen8vvq 8 60 ) ) -RRB- cord-354168-omen8vvq 8 61 . . . cord-354168-omen8vvq 9 1 For for IN cord-354168-omen8vvq 9 2 high high JJ cord-354168-omen8vvq 9 3 - - HYPH cord-354168-omen8vvq 9 4 risk risk NN cord-354168-omen8vvq 9 5 patients patient NNS cord-354168-omen8vvq 9 6 we -PRON- PRP cord-354168-omen8vvq 9 7 recommend recommend VBP cord-354168-omen8vvq 9 8 carfilzomib carfilzomib NNP cord-354168-omen8vvq 9 9 , , , cord-354168-omen8vvq 9 10 lenalidomide lenalidomide NN cord-354168-omen8vvq 9 11 , , , cord-354168-omen8vvq 9 12 and and CC cord-354168-omen8vvq 9 13 dexamethasone dexamethasone NN cord-354168-omen8vvq 9 14 ( ( -LRB- cord-354168-omen8vvq 9 15 KRd KRd NNS cord-354168-omen8vvq 9 16 ) ) -RRB- cord-354168-omen8vvq 9 17 ( ( -LRB- cord-354168-omen8vvq 9 18 preferred prefer VBN cord-354168-omen8vvq 9 19 ) ) -RRB- cord-354168-omen8vvq 9 20 or or CC cord-354168-omen8vvq 9 21 RVd rvd NN cord-354168-omen8vvq 9 22 . . . cord-354168-omen8vvq 10 1 Decreasing decrease VBG cord-354168-omen8vvq 10 2 the the DT cord-354168-omen8vvq 10 3 dose dose NN cord-354168-omen8vvq 10 4 of of IN cord-354168-omen8vvq 10 5 dexamethasone dexamethasone NN cord-354168-omen8vvq 10 6 to to IN cord-354168-omen8vvq 10 7 20 20 CD cord-354168-omen8vvq 10 8 mg mg NN cord-354168-omen8vvq 10 9 and and CC cord-354168-omen8vvq 10 10 giving give VBG cord-354168-omen8vvq 10 11 bortezomib bortezomib NNP cord-354168-omen8vvq 10 12 subcutaneously subcutaneously RB cord-354168-omen8vvq 10 13 once once RB cord-354168-omen8vvq 10 14 a a DT cord-354168-omen8vvq 10 15 week week NN cord-354168-omen8vvq 10 16 is be VBZ cord-354168-omen8vvq 10 17 recommended recommend VBN cord-354168-omen8vvq 10 18 . . . cord-354168-omen8vvq 11 1 We -PRON- PRP cord-354168-omen8vvq 11 2 recommend recommend VBP cord-354168-omen8vvq 11 3 delaying delay VBG cord-354168-omen8vvq 11 4 autologous autologous JJ cord-354168-omen8vvq 11 5 stem stem NN cord-354168-omen8vvq 11 6 cell cell NN cord-354168-omen8vvq 11 7 transplant transplant NN cord-354168-omen8vvq 11 8 ( ( -LRB- cord-354168-omen8vvq 11 9 ASCT ASCT NNP cord-354168-omen8vvq 11 10 ) ) -RRB- cord-354168-omen8vvq 11 11 , , , cord-354168-omen8vvq 11 12 unless unless IN cord-354168-omen8vvq 11 13 the the DT cord-354168-omen8vvq 11 14 patient patient NN cord-354168-omen8vvq 11 15 has have VBZ cord-354168-omen8vvq 11 16 high high JJ cord-354168-omen8vvq 11 17 - - HYPH cord-354168-omen8vvq 11 18 risk risk NN cord-354168-omen8vvq 11 19 disease disease NN cord-354168-omen8vvq 11 20 that that WDT cord-354168-omen8vvq 11 21 is be VBZ cord-354168-omen8vvq 11 22 not not RB cord-354168-omen8vvq 11 23 responding respond VBG cord-354168-omen8vvq 11 24 well well RB cord-354168-omen8vvq 11 25 , , , cord-354168-omen8vvq 11 26 or or CC cord-354168-omen8vvq 11 27 if if IN cord-354168-omen8vvq 11 28 the the DT cord-354168-omen8vvq 11 29 patient patient NN cord-354168-omen8vvq 11 30 has have VBZ cord-354168-omen8vvq 11 31 plasma plasma NN cord-354168-omen8vvq 11 32 cell cell NN cord-354168-omen8vvq 11 33 leukemia leukemia NN cord-354168-omen8vvq 11 34 ( ( -LRB- cord-354168-omen8vvq 11 35 PCL PCL NNP cord-354168-omen8vvq 11 36 ) ) -RRB- cord-354168-omen8vvq 11 37 . . . cord-354168-omen8vvq 12 1 Testing test VBG cord-354168-omen8vvq 12 2 for for IN cord-354168-omen8vvq 12 3 COVID-19 COVID-19 NNP cord-354168-omen8vvq 12 4 should should MD cord-354168-omen8vvq 12 5 be be VB cord-354168-omen8vvq 12 6 done do VBN cord-354168-omen8vvq 12 7 before before IN cord-354168-omen8vvq 12 8 ASCT ASCT NNP cord-354168-omen8vvq 12 9 . . . cord-354168-omen8vvq 13 1 If if IN cord-354168-omen8vvq 13 2 a a DT cord-354168-omen8vvq 13 3 patient patient NN cord-354168-omen8vvq 13 4 achieves achieve VBZ cord-354168-omen8vvq 13 5 a a DT cord-354168-omen8vvq 13 6 very very RB cord-354168-omen8vvq 13 7 good good JJ cord-354168-omen8vvq 13 8 partial partial JJ cord-354168-omen8vvq 13 9 response response NN cord-354168-omen8vvq 13 10 or or CC cord-354168-omen8vvq 13 11 better well JJR cord-354168-omen8vvq 13 12 , , , cord-354168-omen8vvq 13 13 doses dose NNS cord-354168-omen8vvq 13 14 and and CC cord-354168-omen8vvq 13 15 frequency frequency NN cord-354168-omen8vvq 13 16 of of IN cord-354168-omen8vvq 13 17 drug drug NN cord-354168-omen8vvq 13 18 administration administration NN cord-354168-omen8vvq 13 19 can can MD cord-354168-omen8vvq 13 20 be be VB cord-354168-omen8vvq 13 21 modified modify VBN cord-354168-omen8vvq 13 22 . . . cord-354168-omen8vvq 14 1 After after IN cord-354168-omen8vvq 14 2 10–12 10–12 JJ cord-354168-omen8vvq 14 3 cycles cycle NNS cord-354168-omen8vvq 14 4 , , , cord-354168-omen8vvq 14 5 lenalidomide lenalidomide JJ cord-354168-omen8vvq 14 6 maintenance maintenance NN cord-354168-omen8vvq 14 7 is be VBZ cord-354168-omen8vvq 14 8 recommended recommend VBN cord-354168-omen8vvq 14 9 for for IN cord-354168-omen8vvq 14 10 standard standard JJ cord-354168-omen8vvq 14 11 - - HYPH cord-354168-omen8vvq 14 12 risk risk NN cord-354168-omen8vvq 14 13 patients patient NNS cord-354168-omen8vvq 14 14 and and CC cord-354168-omen8vvq 14 15 bortezomib bortezomib NNP cord-354168-omen8vvq 14 16 or or CC cord-354168-omen8vvq 14 17 ixazomib ixazomib NNP cord-354168-omen8vvq 14 18 are be VBP cord-354168-omen8vvq 14 19 recommended recommend VBN cord-354168-omen8vvq 14 20 for for IN cord-354168-omen8vvq 14 21 high high JJ cord-354168-omen8vvq 14 22 - - HYPH cord-354168-omen8vvq 14 23 risk risk NN cord-354168-omen8vvq 14 24 patients patient NNS cord-354168-omen8vvq 14 25 . . . cord-354168-omen8vvq 15 1 Daratumumab Daratumumab NNP cord-354168-omen8vvq 15 2 - - HYPH cord-354168-omen8vvq 15 3 based base VBN cord-354168-omen8vvq 15 4 regimens regimen NNS cord-354168-omen8vvq 15 5 are be VBP cord-354168-omen8vvq 15 6 recommended recommend VBN cord-354168-omen8vvq 15 7 for for IN cord-354168-omen8vvq 15 8 relapsed relapsed JJ cord-354168-omen8vvq 15 9 patients patient NNS cord-354168-omen8vvq 15 10 . . . cord-354168-omen8vvq 16 1 Routine routine JJ cord-354168-omen8vvq 16 2 ASCT ASCT NNP cord-354168-omen8vvq 16 3 is be VBZ cord-354168-omen8vvq 16 4 not not RB cord-354168-omen8vvq 16 5 recommended recommend VBN cord-354168-omen8vvq 16 6 for for IN cord-354168-omen8vvq 16 7 relapse relapse NN cord-354168-omen8vvq 16 8 during during IN cord-354168-omen8vvq 16 9 the the DT cord-354168-omen8vvq 16 10 epidemic epidemic NN cord-354168-omen8vvq 16 11 unless unless IN cord-354168-omen8vvq 16 12 the the DT cord-354168-omen8vvq 16 13 patient patient NN cord-354168-omen8vvq 16 14 has have VBZ cord-354168-omen8vvq 16 15 an an DT cord-354168-omen8vvq 16 16 aggressive aggressive JJ cord-354168-omen8vvq 16 17 relapse relapse NN cord-354168-omen8vvq 16 18 or or CC cord-354168-omen8vvq 16 19 secondary secondary JJ cord-354168-omen8vvq 16 20 PCL PCL NNP cord-354168-omen8vvq 16 21 . . . cord-354168-omen8vvq 17 1 Patients patient NNS cord-354168-omen8vvq 17 2 on on IN cord-354168-omen8vvq 17 3 current current JJ cord-354168-omen8vvq 17 4 maintenance maintenance NN cord-354168-omen8vvq 17 5 should should MD cord-354168-omen8vvq 17 6 continue continue VB cord-354168-omen8vvq 17 7 their -PRON- PRP$ cord-354168-omen8vvq 17 8 therapy therapy NN cord-354168-omen8vvq 17 9 . . . cord-354168-omen8vvq 18 1 The the DT cord-354168-omen8vvq 18 2 management management NN cord-354168-omen8vvq 18 3 of of IN cord-354168-omen8vvq 18 4 patients patient NNS cord-354168-omen8vvq 18 5 with with IN cord-354168-omen8vvq 18 6 cancer cancer NN cord-354168-omen8vvq 18 7 during during IN cord-354168-omen8vvq 18 8 the the DT cord-354168-omen8vvq 18 9 current current JJ cord-354168-omen8vvq 18 10 pandemic pandemic NN cord-354168-omen8vvq 18 11 of of IN cord-354168-omen8vvq 18 12 COVID-19 COVID-19 NNP cord-354168-omen8vvq 18 13 is be VBZ cord-354168-omen8vvq 18 14 challenging challenging JJ cord-354168-omen8vvq 18 15 . . . cord-354168-omen8vvq 19 1 As as IN cord-354168-omen8vvq 19 2 of of IN cord-354168-omen8vvq 19 3 March March NNP cord-354168-omen8vvq 19 4 30 30 CD cord-354168-omen8vvq 19 5 , , , cord-354168-omen8vvq 19 6 2020 2020 CD cord-354168-omen8vvq 19 7 , , , cord-354168-omen8vvq 19 8 more more JJR cord-354168-omen8vvq 19 9 than than IN cord-354168-omen8vvq 19 10 690,000 690,000 CD cord-354168-omen8vvq 19 11 confirmed confirm VBN cord-354168-omen8vvq 19 12 cases case NNS cord-354168-omen8vvq 19 13 and and CC cord-354168-omen8vvq 19 14 more more JJR cord-354168-omen8vvq 19 15 than than IN cord-354168-omen8vvq 19 16 33,000 33,000 CD cord-354168-omen8vvq 19 17 deaths death NNS cord-354168-omen8vvq 19 18 have have VBP cord-354168-omen8vvq 19 19 been be VBN cord-354168-omen8vvq 19 20 documented document VBN cord-354168-omen8vvq 19 21 worldwide worldwide RB cord-354168-omen8vvq 19 22 [ [ -LRB- cord-354168-omen8vvq 19 23 1 1 CD cord-354168-omen8vvq 19 24 ] ] -RRB- cord-354168-omen8vvq 19 25 . . . cord-354168-omen8vvq 20 1 Cancer cancer NN cord-354168-omen8vvq 20 2 patients patient NNS cord-354168-omen8vvq 20 3 require require VBP cord-354168-omen8vvq 20 4 special special JJ cord-354168-omen8vvq 20 5 attention attention NN cord-354168-omen8vvq 20 6 , , , cord-354168-omen8vvq 20 7 as as IN cord-354168-omen8vvq 20 8 decisions decision NNS cord-354168-omen8vvq 20 9 regarding regard VBG cord-354168-omen8vvq 20 10 treatment treatment NN cord-354168-omen8vvq 20 11 during during IN cord-354168-omen8vvq 20 12 the the DT cord-354168-omen8vvq 20 13 current current JJ cord-354168-omen8vvq 20 14 pandemic pandemic NN cord-354168-omen8vvq 20 15 require require VB cord-354168-omen8vvq 20 16 specialized specialized JJ cord-354168-omen8vvq 20 17 consideration consideration NN cord-354168-omen8vvq 20 18 . . . cord-354168-omen8vvq 21 1 The the DT cord-354168-omen8vvq 21 2 quality quality NN cord-354168-omen8vvq 21 3 of of IN cord-354168-omen8vvq 21 4 care care NN cord-354168-omen8vvq 21 5 for for IN cord-354168-omen8vvq 21 6 cancer cancer NN cord-354168-omen8vvq 21 7 patients patient NNS cord-354168-omen8vvq 21 8 has have VBZ cord-354168-omen8vvq 21 9 been be VBN cord-354168-omen8vvq 21 10 affected affect VBN cord-354168-omen8vvq 21 11 during during IN cord-354168-omen8vvq 21 12 this this DT cord-354168-omen8vvq 21 13 pandemic pandemic NN cord-354168-omen8vvq 21 14 [ [ -LRB- cord-354168-omen8vvq 21 15 2 2 CD cord-354168-omen8vvq 21 16 ] ] -RRB- cord-354168-omen8vvq 21 17 [ [ -LRB- cord-354168-omen8vvq 21 18 3 3 CD cord-354168-omen8vvq 21 19 ] ] -RRB- cord-354168-omen8vvq 21 20 [ [ -LRB- cord-354168-omen8vvq 21 21 4 4 CD cord-354168-omen8vvq 21 22 ] ] -RRB- cord-354168-omen8vvq 22 1 [ [ -LRB- cord-354168-omen8vvq 22 2 5 5 CD cord-354168-omen8vvq 22 3 ] ] -RRB- cord-354168-omen8vvq 22 4 and and CC cord-354168-omen8vvq 22 5 strategies strategy NNS cord-354168-omen8vvq 22 6 are be VBP cord-354168-omen8vvq 22 7 required require VBN cord-354168-omen8vvq 22 8 to to TO cord-354168-omen8vvq 22 9 deliver deliver VB cord-354168-omen8vvq 22 10 the the DT cord-354168-omen8vvq 22 11 best good JJS cord-354168-omen8vvq 22 12 care care NN cord-354168-omen8vvq 22 13 . . . cord-354168-omen8vvq 23 1 From from IN cord-354168-omen8vvq 23 2 a a DT cord-354168-omen8vvq 23 3 nationwide nationwide JJ cord-354168-omen8vvq 23 4 analysis analysis NN cord-354168-omen8vvq 23 5 in in IN cord-354168-omen8vvq 23 6 China China NNP cord-354168-omen8vvq 23 7 , , , cord-354168-omen8vvq 23 8 18 18 CD cord-354168-omen8vvq 23 9 ( ( -LRB- cord-354168-omen8vvq 23 10 1 1 CD cord-354168-omen8vvq 23 11 % % NN cord-354168-omen8vvq 23 12 ) ) -RRB- cord-354168-omen8vvq 23 13 out out IN cord-354168-omen8vvq 23 14 of of IN cord-354168-omen8vvq 23 15 1,590 1,590 CD cord-354168-omen8vvq 23 16 COVID-19 covid-19 CD cord-354168-omen8vvq 23 17 cases case NNS cord-354168-omen8vvq 23 18 had have VBD cord-354168-omen8vvq 23 19 a a DT cord-354168-omen8vvq 23 20 history history NN cord-354168-omen8vvq 23 21 of of IN cord-354168-omen8vvq 23 22 cancer cancer NN cord-354168-omen8vvq 23 23 [ [ -LRB- cord-354168-omen8vvq 23 24 6 6 CD cord-354168-omen8vvq 23 25 ] ] -RRB- cord-354168-omen8vvq 23 26 . . . cord-354168-omen8vvq 24 1 Patients patient NNS cord-354168-omen8vvq 24 2 with with IN cord-354168-omen8vvq 24 3 cancer cancer NN cord-354168-omen8vvq 24 4 were be VBD cord-354168-omen8vvq 24 5 more more RBR cord-354168-omen8vvq 24 6 likely likely JJ cord-354168-omen8vvq 24 7 to to TO cord-354168-omen8vvq 24 8 be be VB cord-354168-omen8vvq 24 9 older old JJR cord-354168-omen8vvq 24 10 and and CC cord-354168-omen8vvq 24 11 had have VBD cord-354168-omen8vvq 24 12 more more RBR cord-354168-omen8vvq 24 13 frequently frequently RB cord-354168-omen8vvq 24 14 abnormal abnormal JJ cord-354168-omen8vvq 24 15 computed compute VBN cord-354168-omen8vvq 24 16 tomography tomography NN cord-354168-omen8vvq 24 17 ( ( -LRB- cord-354168-omen8vvq 24 18 CT CT NNP cord-354168-omen8vvq 24 19 ) ) -RRB- cord-354168-omen8vvq 24 20 scans scan NNS cord-354168-omen8vvq 24 21 . . . cord-354168-omen8vvq 25 1 More more RBR cord-354168-omen8vvq 25 2 significantly significantly RB cord-354168-omen8vvq 25 3 , , , cord-354168-omen8vvq 25 4 patients patient NNS cord-354168-omen8vvq 25 5 with with IN cord-354168-omen8vvq 25 6 cancer cancer NN cord-354168-omen8vvq 25 7 infected infect VBN cord-354168-omen8vvq 25 8 with with IN cord-354168-omen8vvq 25 9 coronavirus coronavirus NN cord-354168-omen8vvq 25 10 were be VBD cord-354168-omen8vvq 25 11 more more RBR cord-354168-omen8vvq 25 12 likely likely JJ cord-354168-omen8vvq 25 13 to to TO cord-354168-omen8vvq 25 14 have have VB cord-354168-omen8vvq 25 15 an an DT cord-354168-omen8vvq 25 16 adverse adverse JJ cord-354168-omen8vvq 25 17 event event NN cord-354168-omen8vvq 25 18 defined define VBN cord-354168-omen8vvq 25 19 as as IN cord-354168-omen8vvq 25 20 admission admission NN cord-354168-omen8vvq 25 21 to to IN cord-354168-omen8vvq 25 22 the the DT cord-354168-omen8vvq 25 23 intensive intensive JJ cord-354168-omen8vvq 25 24 care care NN cord-354168-omen8vvq 25 25 unit unit NN cord-354168-omen8vvq 25 26 requiring require VBG cord-354168-omen8vvq 25 27 ventilation ventilation NN cord-354168-omen8vvq 25 28 or or CC cord-354168-omen8vvq 25 29 death death NN cord-354168-omen8vvq 25 30 ( ( -LRB- cord-354168-omen8vvq 25 31 39 39 CD cord-354168-omen8vvq 25 32 vs. vs. CC cord-354168-omen8vvq 25 33 8 8 CD cord-354168-omen8vvq 25 34 % % NN cord-354168-omen8vvq 25 35 , , , cord-354168-omen8vvq 25 36 p p NN cord-354168-omen8vvq 25 37 = = SYM cord-354168-omen8vvq 25 38 0.0003 0.0003 CD cord-354168-omen8vvq 25 39 ) ) -RRB- cord-354168-omen8vvq 25 40 . . . cord-354168-omen8vvq 26 1 Cancer cancer NN cord-354168-omen8vvq 26 2 patients patient NNS cord-354168-omen8vvq 26 3 also also RB cord-354168-omen8vvq 26 4 had have VBD cord-354168-omen8vvq 26 5 a a DT cord-354168-omen8vvq 26 6 shorter short JJR cord-354168-omen8vvq 26 7 median median JJ cord-354168-omen8vvq 26 8 time time NN cord-354168-omen8vvq 26 9 to to IN cord-354168-omen8vvq 26 10 severe severe JJ cord-354168-omen8vvq 26 11 events event NNS cord-354168-omen8vvq 26 12 ( ( -LRB- cord-354168-omen8vvq 26 13 13 13 CD cord-354168-omen8vvq 26 14 vs vs IN cord-354168-omen8vvq 26 15 . . . cord-354168-omen8vvq 27 1 43 43 CD cord-354168-omen8vvq 27 2 days day NNS cord-354168-omen8vvq 27 3 , , , cord-354168-omen8vvq 27 4 p p NN cord-354168-omen8vvq 27 5 < < XX cord-354168-omen8vvq 27 6 0.0001 0.0001 CD cord-354168-omen8vvq 27 7 ) ) -RRB- cord-354168-omen8vvq 27 8 . . . cord-354168-omen8vvq 28 1 Cancer cancer NN cord-354168-omen8vvq 28 2 , , , cord-354168-omen8vvq 28 3 as as IN cord-354168-omen8vvq 28 4 a a DT cord-354168-omen8vvq 28 5 variable variable NN cord-354168-omen8vvq 28 6 , , , cord-354168-omen8vvq 28 7 had have VBD cord-354168-omen8vvq 28 8 the the DT cord-354168-omen8vvq 28 9 highest high JJS cord-354168-omen8vvq 28 10 odds odd NNS cord-354168-omen8vvq 28 11 ratio ratio NN cord-354168-omen8vvq 28 12 [ [ -LRB- cord-354168-omen8vvq 28 13 5 5 CD cord-354168-omen8vvq 28 14 , , , cord-354168-omen8vvq 28 15 3 3 CD cord-354168-omen8vvq 28 16 ] ] -RRB- cord-354168-omen8vvq 28 17 for for IN cord-354168-omen8vvq 28 18 having have VBG cord-354168-omen8vvq 28 19 adverse adverse JJ cord-354168-omen8vvq 28 20 events event NNS cord-354168-omen8vvq 28 21 . . . cord-354168-omen8vvq 29 1 Despite despite IN cord-354168-omen8vvq 29 2 the the DT cord-354168-omen8vvq 29 3 limitation limitation NN cord-354168-omen8vvq 29 4 of of IN cord-354168-omen8vvq 29 5 a a DT cord-354168-omen8vvq 29 6 small small JJ cord-354168-omen8vvq 29 7 sample sample NN cord-354168-omen8vvq 29 8 size size NN cord-354168-omen8vvq 29 9 and and CC cord-354168-omen8vvq 29 10 the the DT cord-354168-omen8vvq 29 11 heterogeneity heterogeneity NN cord-354168-omen8vvq 29 12 of of IN cord-354168-omen8vvq 29 13 cancer cancer NN cord-354168-omen8vvq 29 14 patients patient NNS cord-354168-omen8vvq 29 15 , , , cord-354168-omen8vvq 29 16 these these DT cord-354168-omen8vvq 29 17 results result NNS cord-354168-omen8vvq 29 18 are be VBP cord-354168-omen8vvq 29 19 concerning concern VBG cord-354168-omen8vvq 29 20 . . . cord-354168-omen8vvq 30 1 Cancers cancer NNS cord-354168-omen8vvq 30 2 differ differ VBP cord-354168-omen8vvq 30 3 in in IN cord-354168-omen8vvq 30 4 their -PRON- PRP$ cord-354168-omen8vvq 30 5 pathogenesis pathogenesis NN cord-354168-omen8vvq 30 6 and and CC cord-354168-omen8vvq 30 7 the the DT cord-354168-omen8vvq 30 8 urgency urgency NN cord-354168-omen8vvq 30 9 of of IN cord-354168-omen8vvq 30 10 starting start VBG cord-354168-omen8vvq 30 11 treatment treatment NN cord-354168-omen8vvq 30 12 is be VBZ cord-354168-omen8vvq 30 13 not not RB cord-354168-omen8vvq 30 14 the the DT cord-354168-omen8vvq 30 15 same same JJ cord-354168-omen8vvq 30 16 for for IN cord-354168-omen8vvq 30 17 all all DT cord-354168-omen8vvq 30 18 cancers cancer NNS cord-354168-omen8vvq 30 19 . . . cord-354168-omen8vvq 31 1 We -PRON- PRP cord-354168-omen8vvq 31 2 report report VBP cord-354168-omen8vvq 31 3 our -PRON- PRP$ cord-354168-omen8vvq 31 4 personal personal JJ cord-354168-omen8vvq 31 5 opinions opinion NNS cord-354168-omen8vvq 31 6 regarding regard VBG cord-354168-omen8vvq 31 7 the the DT cord-354168-omen8vvq 31 8 management management NN cord-354168-omen8vvq 31 9 of of IN cord-354168-omen8vvq 31 10 patients patient NNS cord-354168-omen8vvq 31 11 with with IN cord-354168-omen8vvq 31 12 multiple multiple JJ cord-354168-omen8vvq 31 13 myeloma myeloma NN cord-354168-omen8vvq 31 14 ( ( -LRB- cord-354168-omen8vvq 31 15 MM MM NNP cord-354168-omen8vvq 31 16 ) ) -RRB- cord-354168-omen8vvq 31 17 during during IN cord-354168-omen8vvq 31 18 this this DT cord-354168-omen8vvq 31 19 challenging challenging JJ cord-354168-omen8vvq 31 20 time time NN cord-354168-omen8vvq 31 21 . . . cord-354168-omen8vvq 32 1 The the DT cord-354168-omen8vvq 32 2 reader reader NN cord-354168-omen8vvq 32 3 is be VBZ cord-354168-omen8vvq 32 4 advised advise VBN cord-354168-omen8vvq 32 5 that that IN cord-354168-omen8vvq 32 6 these these DT cord-354168-omen8vvq 32 7 recommendations recommendation NNS cord-354168-omen8vvq 32 8 are be VBP cord-354168-omen8vvq 32 9 based base VBN cord-354168-omen8vvq 32 10 on on IN cord-354168-omen8vvq 32 11 experience experience NN cord-354168-omen8vvq 32 12 and and CC cord-354168-omen8vvq 32 13 are be VBP cord-354168-omen8vvq 32 14 not not RB cord-354168-omen8vvq 32 15 evidence evidence NN cord-354168-omen8vvq 32 16 based base VBN cord-354168-omen8vvq 32 17 . . . cord-354168-omen8vvq 33 1 What what WP cord-354168-omen8vvq 33 2 Is be VBZ cord-354168-omen8vvq 33 3 Special special JJ cord-354168-omen8vvq 33 4 about about IN cord-354168-omen8vvq 33 5 MM MM NNP cord-354168-omen8vvq 33 6 Patients patient NNS cord-354168-omen8vvq 33 7 ? ? . cord-354168-omen8vvq 34 1 The the DT cord-354168-omen8vvq 34 2 immune immune JJ cord-354168-omen8vvq 34 3 system system NN cord-354168-omen8vvq 34 4 in in IN cord-354168-omen8vvq 34 5 patients patient NNS cord-354168-omen8vvq 34 6 with with IN cord-354168-omen8vvq 34 7 MM MM NNP cord-354168-omen8vvq 34 8 is be VBZ cord-354168-omen8vvq 34 9 compromised compromise VBN cord-354168-omen8vvq 34 10 by by IN cord-354168-omen8vvq 34 11 many many JJ cord-354168-omen8vvq 34 12 different different JJ cord-354168-omen8vvq 34 13 factors factor NNS cord-354168-omen8vvq 34 14 and and CC cord-354168-omen8vvq 34 15 patients patient NNS cord-354168-omen8vvq 34 16 with with IN cord-354168-omen8vvq 34 17 MM MM NNP cord-354168-omen8vvq 34 18 are be VBP cord-354168-omen8vvq 34 19 at at IN cord-354168-omen8vvq 34 20 increased increase VBN cord-354168-omen8vvq 34 21 risk risk NN cord-354168-omen8vvq 34 22 of of IN cord-354168-omen8vvq 34 23 infection infection NN cord-354168-omen8vvq 34 24 [ [ -LRB- cord-354168-omen8vvq 34 25 7 7 CD cord-354168-omen8vvq 34 26 ] ] -RRB- cord-354168-omen8vvq 34 27 . . . cord-354168-omen8vvq 35 1 The the DT cord-354168-omen8vvq 35 2 mean mean JJ cord-354168-omen8vvq 35 3 age age NN cord-354168-omen8vvq 35 4 at at IN cord-354168-omen8vvq 35 5 diagnosis diagnosis NN cord-354168-omen8vvq 35 6 for for IN cord-354168-omen8vvq 35 7 myeloma myeloma NN cord-354168-omen8vvq 35 8 is be VBZ cord-354168-omen8vvq 35 9 approximately approximately RB cord-354168-omen8vvq 35 10 65 65 CD cord-354168-omen8vvq 35 11 and and CC cord-354168-omen8vvq 35 12 elderly elderly JJ cord-354168-omen8vvq 35 13 patients patient NNS cord-354168-omen8vvq 35 14 are be VBP cord-354168-omen8vvq 35 15 more more RBR cord-354168-omen8vvq 35 16 likely likely JJ cord-354168-omen8vvq 35 17 to to TO cord-354168-omen8vvq 35 18 have have VB cord-354168-omen8vvq 35 19 comorbidities comorbiditie NNS cord-354168-omen8vvq 35 20 compromising compromise VBG cord-354168-omen8vvq 35 21 the the DT cord-354168-omen8vvq 35 22 immune immune JJ cord-354168-omen8vvq 35 23 system system NN cord-354168-omen8vvq 35 24 . . . cord-354168-omen8vvq 36 1 Lymphopenia Lymphopenia NNP cord-354168-omen8vvq 36 2 at at IN cord-354168-omen8vvq 36 3 diagnosis diagnosis NN cord-354168-omen8vvq 36 4 is be VBZ cord-354168-omen8vvq 36 5 a a DT cord-354168-omen8vvq 36 6 well well RB cord-354168-omen8vvq 36 7 - - HYPH cord-354168-omen8vvq 36 8 known know VBN cord-354168-omen8vvq 36 9 risk risk NN cord-354168-omen8vvq 36 10 factor factor NN cord-354168-omen8vvq 36 11 for for IN cord-354168-omen8vvq 36 12 developing develop VBG cord-354168-omen8vvq 36 13 infections infection NNS cord-354168-omen8vvq 36 14 [ [ -LRB- cord-354168-omen8vvq 36 15 8 8 CD cord-354168-omen8vvq 36 16 ] ] -RRB- cord-354168-omen8vvq 36 17 [ [ -LRB- cord-354168-omen8vvq 36 18 9 9 CD cord-354168-omen8vvq 36 19 ] ] -RRB- cord-354168-omen8vvq 36 20 [ [ -LRB- cord-354168-omen8vvq 36 21 10 10 CD cord-354168-omen8vvq 36 22 ] ] -RRB- cord-354168-omen8vvq 36 23 . . . cord-354168-omen8vvq 37 1 This this DT cord-354168-omen8vvq 37 2 is be VBZ cord-354168-omen8vvq 37 3 a a DT cord-354168-omen8vvq 37 4 result result NN cord-354168-omen8vvq 37 5 of of IN cord-354168-omen8vvq 37 6 the the DT cord-354168-omen8vvq 37 7 myeloma myeloma NN cord-354168-omen8vvq 37 8 clone clone NN cord-354168-omen8vvq 37 9 suppressing suppress VBG cord-354168-omen8vvq 37 10 normal normal JJ cord-354168-omen8vvq 37 11 B b NN cord-354168-omen8vvq 37 12 - - HYPH cord-354168-omen8vvq 37 13 cell cell NN cord-354168-omen8vvq 37 14 development development NN cord-354168-omen8vvq 37 15 and and CC cord-354168-omen8vvq 37 16 function function NN cord-354168-omen8vvq 37 17 . . . cord-354168-omen8vvq 38 1 A a DT cord-354168-omen8vvq 38 2 loss loss NN cord-354168-omen8vvq 38 3 of of IN cord-354168-omen8vvq 38 4 functional functional JJ cord-354168-omen8vvq 38 5 immunoglobulins immunoglobulin NNS cord-354168-omen8vvq 38 6 seen see VBN cord-354168-omen8vvq 38 7 in in IN cord-354168-omen8vvq 38 8 most most JJS cord-354168-omen8vvq 38 9 myeloma myeloma NN cord-354168-omen8vvq 38 10 patients patient NNS cord-354168-omen8vvq 38 11 can can MD cord-354168-omen8vvq 38 12 also also RB cord-354168-omen8vvq 38 13 contribute contribute VB cord-354168-omen8vvq 38 14 to to IN cord-354168-omen8vvq 38 15 the the DT cord-354168-omen8vvq 38 16 increased increase VBN cord-354168-omen8vvq 38 17 risk risk NN cord-354168-omen8vvq 38 18 of of IN cord-354168-omen8vvq 38 19 infection infection NN cord-354168-omen8vvq 38 20 . . . cord-354168-omen8vvq 39 1 Decreased decrease VBN cord-354168-omen8vvq 40 1 CD+4 CD+4 NNP cord-354168-omen8vvq 40 2 T t NN cord-354168-omen8vvq 40 3 - - HYPH cord-354168-omen8vvq 40 4 cell cell NN cord-354168-omen8vvq 40 5 count count NN cord-354168-omen8vvq 40 6 at at IN cord-354168-omen8vvq 40 7 diagnosis diagnosis NN cord-354168-omen8vvq 40 8 is be VBZ cord-354168-omen8vvq 40 9 also also RB cord-354168-omen8vvq 40 10 associated associate VBN cord-354168-omen8vvq 40 11 with with IN cord-354168-omen8vvq 40 12 increased increase VBN cord-354168-omen8vvq 40 13 infections infection NNS cord-354168-omen8vvq 40 14 [ [ -LRB- cord-354168-omen8vvq 40 15 11 11 CD cord-354168-omen8vvq 40 16 , , , cord-354168-omen8vvq 40 17 12 12 CD cord-354168-omen8vvq 40 18 ] ] -RRB- cord-354168-omen8vvq 40 19 . . . cord-354168-omen8vvq 41 1 Patients patient NNS cord-354168-omen8vvq 41 2 with with IN cord-354168-omen8vvq 41 3 MM MM NNP cord-354168-omen8vvq 41 4 receive receive VBP cord-354168-omen8vvq 41 5 treatment treatment NN cord-354168-omen8vvq 41 6 that that WDT cord-354168-omen8vvq 41 7 causes cause VBZ cord-354168-omen8vvq 41 8 more more JJR cord-354168-omen8vvq 41 9 immunosuppression immunosuppression NN cord-354168-omen8vvq 41 10 and and CC cord-354168-omen8vvq 41 11 increases increase VBZ cord-354168-omen8vvq 41 12 the the DT cord-354168-omen8vvq 41 13 risk risk NN cord-354168-omen8vvq 41 14 of of IN cord-354168-omen8vvq 41 15 infection infection NN cord-354168-omen8vvq 41 16 [ [ -LRB- cord-354168-omen8vvq 41 17 13 13 CD cord-354168-omen8vvq 41 18 ] ] -RRB- cord-354168-omen8vvq 41 19 . . . cord-354168-omen8vvq 42 1 Lymphopenia Lymphopenia NNP cord-354168-omen8vvq 42 2 worsens worsen VBZ cord-354168-omen8vvq 42 3 after after IN cord-354168-omen8vvq 42 4 starting start VBG cord-354168-omen8vvq 42 5 therapy therapy NN cord-354168-omen8vvq 42 6 for for IN cord-354168-omen8vvq 42 7 MM MM NNP cord-354168-omen8vvq 42 8 [ [ -LRB- cord-354168-omen8vvq 42 9 10 10 CD cord-354168-omen8vvq 42 10 ] ] -RRB- cord-354168-omen8vvq 42 11 and and CC cord-354168-omen8vvq 42 12 CD4 CD4 NNP cord-354168-omen8vvq 42 13 counts count VBZ cord-354168-omen8vvq 42 14 decrease decrease NN cord-354168-omen8vvq 42 15 with with IN cord-354168-omen8vvq 42 16 proteasome proteasome VBN cord-354168-omen8vvq 42 17 inhibitor inhibitor NN cord-354168-omen8vvq 42 18 ( ( -LRB- cord-354168-omen8vvq 42 19 PI pi NN cord-354168-omen8vvq 42 20 ) ) -RRB- cord-354168-omen8vvq 42 21 therapy therapy NN cord-354168-omen8vvq 42 22 [ [ -LRB- cord-354168-omen8vvq 42 23 14 14 CD cord-354168-omen8vvq 42 24 ] ] -RRB- cord-354168-omen8vvq 42 25 , , , cord-354168-omen8vvq 42 26 and and CC cord-354168-omen8vvq 42 27 the the DT cord-354168-omen8vvq 42 28 risk risk NN cord-354168-omen8vvq 42 29 of of IN cord-354168-omen8vvq 42 30 zoster zoster NN cord-354168-omen8vvq 42 31 reactivation reactivation NN cord-354168-omen8vvq 42 32 is be VBZ cord-354168-omen8vvq 42 33 up up IN cord-354168-omen8vvq 42 34 to to TO cord-354168-omen8vvq 42 35 13 13 CD cord-354168-omen8vvq 42 36 % % NN cord-354168-omen8vvq 42 37 without without IN cord-354168-omen8vvq 42 38 prophylaxis prophylaxis NN cord-354168-omen8vvq 42 39 [ [ -LRB- cord-354168-omen8vvq 42 40 15 15 CD cord-354168-omen8vvq 42 41 ] ] -RRB- cord-354168-omen8vvq 42 42 . . . cord-354168-omen8vvq 43 1 Immunomodulatory immunomodulatory JJ cord-354168-omen8vvq 43 2 drugs drug NNS cord-354168-omen8vvq 44 1 ( ( -LRB- cord-354168-omen8vvq 44 2 IMiDs imids NN cord-354168-omen8vvq 44 3 ) ) -RRB- cord-354168-omen8vvq 44 4 cause cause NN cord-354168-omen8vvq 44 5 neutropenia neutropenia NN cord-354168-omen8vvq 44 6 , , , cord-354168-omen8vvq 44 7 which which WDT cord-354168-omen8vvq 44 8 increases increase VBZ cord-354168-omen8vvq 44 9 the the DT cord-354168-omen8vvq 44 10 infection infection NN cord-354168-omen8vvq 44 11 risk risk NN cord-354168-omen8vvq 44 12 . . . cord-354168-omen8vvq 45 1 Steroids steroid NNS cord-354168-omen8vvq 45 2 are be VBP cord-354168-omen8vvq 45 3 well well RB cord-354168-omen8vvq 45 4 known know VBN cord-354168-omen8vvq 45 5 to to TO cord-354168-omen8vvq 45 6 increase increase VB cord-354168-omen8vvq 45 7 the the DT cord-354168-omen8vvq 45 8 risk risk NN cord-354168-omen8vvq 45 9 of of IN cord-354168-omen8vvq 45 10 infections infection NNS cord-354168-omen8vvq 45 11 ( ( -LRB- cord-354168-omen8vvq 45 12 including include VBG cord-354168-omen8vvq 45 13 pneumocystis pneumocystis NN cord-354168-omen8vvq 45 14 and and CC cord-354168-omen8vvq 45 15 fungus fungus NN cord-354168-omen8vvq 45 16 ) ) -RRB- cord-354168-omen8vvq 45 17 and and CC cord-354168-omen8vvq 45 18 the the DT cord-354168-omen8vvq 45 19 combination combination NN cord-354168-omen8vvq 45 20 with with IN cord-354168-omen8vvq 45 21 IMiDs imids NN cord-354168-omen8vvq 45 22 and and CC cord-354168-omen8vvq 45 23 PIs pis NN cord-354168-omen8vvq 45 24 increases increase VBZ cord-354168-omen8vvq 45 25 this this DT cord-354168-omen8vvq 45 26 further further RB cord-354168-omen8vvq 45 27 . . . cord-354168-omen8vvq 46 1 The the DT cord-354168-omen8vvq 46 2 infection infection NN cord-354168-omen8vvq 46 3 risk risk NN cord-354168-omen8vvq 46 4 is be VBZ cord-354168-omen8vvq 46 5 highest high JJS cord-354168-omen8vvq 46 6 during during IN cord-354168-omen8vvq 46 7 the the DT cord-354168-omen8vvq 46 8 first first JJ cord-354168-omen8vvq 46 9 3 3 CD cord-354168-omen8vvq 46 10 - - SYM cord-354168-omen8vvq 46 11 4 4 CD cord-354168-omen8vvq 46 12 months month NNS cord-354168-omen8vvq 46 13 of of IN cord-354168-omen8vvq 46 14 therapy therapy NN cord-354168-omen8vvq 46 15 . . . cord-354168-omen8vvq 47 1 Prophylactic prophylactic JJ cord-354168-omen8vvq 47 2 levofloxacin levofloxacin NNS cord-354168-omen8vvq 47 3 for for IN cord-354168-omen8vvq 47 4 12 12 CD cord-354168-omen8vvq 47 5 weeks week NNS cord-354168-omen8vvq 47 6 in in IN cord-354168-omen8vvq 47 7 newly newly RB cord-354168-omen8vvq 47 8 diagnosed diagnose VBN cord-354168-omen8vvq 47 9 myeloma myeloma NN cord-354168-omen8vvq 47 10 has have VBZ cord-354168-omen8vvq 47 11 been be VBN cord-354168-omen8vvq 47 12 shown show VBN cord-354168-omen8vvq 47 13 to to TO cord-354168-omen8vvq 47 14 reduce reduce VB cord-354168-omen8vvq 47 15 deaths death NNS cord-354168-omen8vvq 47 16 significantly significantly RB cord-354168-omen8vvq 47 17 [ [ -LRB- cord-354168-omen8vvq 47 18 16 16 CD cord-354168-omen8vvq 47 19 ] ] -RRB- cord-354168-omen8vvq 47 20 . . . cord-354168-omen8vvq 48 1 All all DT cord-354168-omen8vvq 48 2 of of IN cord-354168-omen8vvq 48 3 the the DT cord-354168-omen8vvq 48 4 previous previous JJ cord-354168-omen8vvq 48 5 factors factor NNS cord-354168-omen8vvq 48 6 make make VBP cord-354168-omen8vvq 48 7 MM MM NNP cord-354168-omen8vvq 48 8 patients patient NNS cord-354168-omen8vvq 48 9 more more RBR cord-354168-omen8vvq 48 10 susceptible susceptible JJ cord-354168-omen8vvq 48 11 to to IN cord-354168-omen8vvq 48 12 the the DT cord-354168-omen8vvq 48 13 serious serious JJ cord-354168-omen8vvq 48 14 adverse adverse JJ cord-354168-omen8vvq 48 15 events event NNS cord-354168-omen8vvq 48 16 that that WDT cord-354168-omen8vvq 48 17 could could MD cord-354168-omen8vvq 48 18 arise arise VB cord-354168-omen8vvq 48 19 with with IN cord-354168-omen8vvq 48 20 COVID-19 covid-19 JJ cord-354168-omen8vvq 48 21 infection infection NN cord-354168-omen8vvq 48 22 . . . cord-354168-omen8vvq 49 1 COVID-19 COVID-19 NNP cord-354168-omen8vvq 49 2 can can MD cord-354168-omen8vvq 49 3 intensify intensify VB cord-354168-omen8vvq 49 4 neutropenia neutropenia NN cord-354168-omen8vvq 49 5 [ [ -LRB- cord-354168-omen8vvq 49 6 17 17 CD cord-354168-omen8vvq 49 7 ] ] -RRB- cord-354168-omen8vvq 49 8 . . . cord-354168-omen8vvq 50 1 There there EX cord-354168-omen8vvq 50 2 is be VBZ cord-354168-omen8vvq 50 3 no no DT cord-354168-omen8vvq 50 4 disagreement disagreement NN cord-354168-omen8vvq 50 5 regarding regard VBG cord-354168-omen8vvq 50 6 the the DT cord-354168-omen8vvq 50 7 management management NN cord-354168-omen8vvq 50 8 of of IN cord-354168-omen8vvq 50 9 standard standard JJ cord-354168-omen8vvq 50 10 - - HYPH cord-354168-omen8vvq 50 11 risk risk NN cord-354168-omen8vvq 50 12 smoldering smolder VBG cord-354168-omen8vvq 50 13 MM MM NNP cord-354168-omen8vvq 50 14 ( ( -LRB- cord-354168-omen8vvq 50 15 SMM SMM NNP cord-354168-omen8vvq 50 16 ) ) -RRB- cord-354168-omen8vvq 50 17 patients patient NNS cord-354168-omen8vvq 50 18 . . . cord-354168-omen8vvq 51 1 These these DT cord-354168-omen8vvq 51 2 patients patient NNS cord-354168-omen8vvq 51 3 should should MD cord-354168-omen8vvq 51 4 be be VB cord-354168-omen8vvq 51 5 monitored monitor VBN cord-354168-omen8vvq 51 6 with with IN cord-354168-omen8vvq 51 7 no no DT cord-354168-omen8vvq 51 8 active active JJ cord-354168-omen8vvq 51 9 intervention intervention NN cord-354168-omen8vvq 51 10 . . . cord-354168-omen8vvq 52 1 For for IN cord-354168-omen8vvq 52 2 high high JJ cord-354168-omen8vvq 52 3 - - HYPH cord-354168-omen8vvq 52 4 risk risk NN cord-354168-omen8vvq 52 5 SMM SMM NNP cord-354168-omen8vvq 52 6 based base VBN cord-354168-omen8vvq 52 7 on on IN cord-354168-omen8vvq 52 8 the the DT cord-354168-omen8vvq 52 9 Mayo Mayo NNP cord-354168-omen8vvq 52 10 2018 2018 CD cord-354168-omen8vvq 52 11 risk risk NN cord-354168-omen8vvq 52 12 stratification stratification NN cord-354168-omen8vvq 52 13 [ [ -LRB- cord-354168-omen8vvq 52 14 18 18 CD cord-354168-omen8vvq 52 15 ] ] -RRB- cord-354168-omen8vvq 52 16 , , , cord-354168-omen8vvq 52 17 experts expert NNS cord-354168-omen8vvq 52 18 differ differ VBP cord-354168-omen8vvq 52 19 in in IN cord-354168-omen8vvq 52 20 their -PRON- PRP$ cord-354168-omen8vvq 52 21 approach approach NN cord-354168-omen8vvq 52 22 . . . cord-354168-omen8vvq 53 1 Two two CD cord-354168-omen8vvq 53 2 phase phase NN cord-354168-omen8vvq 53 3 III iii CD cord-354168-omen8vvq 53 4 randomized randomized JJ cord-354168-omen8vvq 53 5 trials trial NNS cord-354168-omen8vvq 53 6 evaluated evaluate VBD cord-354168-omen8vvq 53 7 the the DT cord-354168-omen8vvq 53 8 use use NN cord-354168-omen8vvq 53 9 of of IN cord-354168-omen8vvq 53 10 active active JJ cord-354168-omen8vvq 53 11 therapy therapy NN cord-354168-omen8vvq 53 12 for for IN cord-354168-omen8vvq 53 13 SMM SMM NNP cord-354168-omen8vvq 53 14 , , , cord-354168-omen8vvq 53 15 one one CD cord-354168-omen8vvq 53 16 with with IN cord-354168-omen8vvq 53 17 lenalidomide lenalidomide NN cord-354168-omen8vvq 53 18 and and CC cord-354168-omen8vvq 53 19 dexamethasone dexamethasone NN cord-354168-omen8vvq 53 20 [ [ -LRB- cord-354168-omen8vvq 53 21 19 19 CD cord-354168-omen8vvq 53 22 ] ] -RRB- cord-354168-omen8vvq 53 23 and and CC cord-354168-omen8vvq 53 24 the the DT cord-354168-omen8vvq 53 25 other other JJ cord-354168-omen8vvq 53 26 with with IN cord-354168-omen8vvq 53 27 lenalidomide lenalidomide NN cord-354168-omen8vvq 53 28 alone alone RB cord-354168-omen8vvq 53 29 [ [ -LRB- cord-354168-omen8vvq 53 30 20 20 CD cord-354168-omen8vvq 53 31 ] ] -RRB- cord-354168-omen8vvq 53 32 . . . cord-354168-omen8vvq 54 1 There there EX cord-354168-omen8vvq 54 2 was be VBD cord-354168-omen8vvq 54 3 improvement improvement NN cord-354168-omen8vvq 54 4 in in IN cord-354168-omen8vvq 54 5 progression progression NN cord-354168-omen8vvq 54 6 - - HYPH cord-354168-omen8vvq 54 7 free free JJ cord-354168-omen8vvq 54 8 survival survival NN cord-354168-omen8vvq 54 9 ( ( -LRB- cord-354168-omen8vvq 54 10 PFS PFS NNP cord-354168-omen8vvq 54 11 ) ) -RRB- cord-354168-omen8vvq 54 12 in in IN cord-354168-omen8vvq 54 13 2 2 CD cord-354168-omen8vvq 54 14 trials trial NNS cord-354168-omen8vvq 54 15 [ [ -LRB- cord-354168-omen8vvq 54 16 19 19 CD cord-354168-omen8vvq 54 17 , , , cord-354168-omen8vvq 54 18 20 20 CD cord-354168-omen8vvq 54 19 ] ] -RRB- cord-354168-omen8vvq 54 20 and and CC cord-354168-omen8vvq 54 21 overall overall JJ cord-354168-omen8vvq 54 22 survival survival NN cord-354168-omen8vvq 54 23 ( ( -LRB- cord-354168-omen8vvq 54 24 OS OS NNP cord-354168-omen8vvq 54 25 ) ) -RRB- cord-354168-omen8vvq 54 26 in in IN cord-354168-omen8vvq 54 27 1 1 CD cord-354168-omen8vvq 54 28 trial trial NN cord-354168-omen8vvq 54 29 [ [ -LRB- cord-354168-omen8vvq 54 30 19 19 CD cord-354168-omen8vvq 54 31 ] ] -RRB- cord-354168-omen8vvq 54 32 . . . cord-354168-omen8vvq 55 1 However however RB cord-354168-omen8vvq 55 2 , , , cord-354168-omen8vvq 55 3 both both DT cord-354168-omen8vvq 55 4 trials trial NNS cord-354168-omen8vvq 55 5 had have VBD cord-354168-omen8vvq 55 6 several several JJ cord-354168-omen8vvq 55 7 limitations limitation NNS cord-354168-omen8vvq 55 8 . . . cord-354168-omen8vvq 56 1 In in IN cord-354168-omen8vvq 56 2 both both DT cord-354168-omen8vvq 56 3 trials trial NNS cord-354168-omen8vvq 56 4 , , , cord-354168-omen8vvq 56 5 the the DT cord-354168-omen8vvq 56 6 sample sample NN cord-354168-omen8vvq 56 7 size size NN cord-354168-omen8vvq 56 8 was be VBD cord-354168-omen8vvq 56 9 less less JJR cord-354168-omen8vvq 56 10 than than IN cord-354168-omen8vvq 56 11 100 100 CD cord-354168-omen8vvq 56 12 patients patient NNS cord-354168-omen8vvq 56 13 in in IN cord-354168-omen8vvq 56 14 each each DT cord-354168-omen8vvq 56 15 arm arm NN cord-354168-omen8vvq 56 16 . . . cord-354168-omen8vvq 57 1 In in IN cord-354168-omen8vvq 57 2 the the DT cord-354168-omen8vvq 57 3 Spanish spanish JJ cord-354168-omen8vvq 57 4 myeloma myeloma NN cord-354168-omen8vvq 57 5 group group NN cord-354168-omen8vvq 57 6 trial trial NN cord-354168-omen8vvq 57 7 [ [ -LRB- cord-354168-omen8vvq 57 8 19 19 CD cord-354168-omen8vvq 57 9 ] ] -RRB- cord-354168-omen8vvq 57 10 , , , cord-354168-omen8vvq 57 11 imaging imaging NN cord-354168-omen8vvq 57 12 was be VBD cord-354168-omen8vvq 57 13 done do VBN cord-354168-omen8vvq 57 14 using use VBG cord-354168-omen8vvq 57 15 X x NN cord-354168-omen8vvq 57 16 - - NN cord-354168-omen8vvq 57 17 ray ray NN cord-354168-omen8vvq 57 18 , , , cord-354168-omen8vvq 57 19 which which WDT cord-354168-omen8vvq 57 20 is be VBZ cord-354168-omen8vvq 57 21 less less RBR cord-354168-omen8vvq 57 22 sensitive sensitive JJ cord-354168-omen8vvq 57 23 than than IN cord-354168-omen8vvq 57 24 current current JJ cord-354168-omen8vvq 57 25 diagnostic diagnostic JJ cord-354168-omen8vvq 57 26 modalities modality NNS cord-354168-omen8vvq 57 27 ( ( -LRB- cord-354168-omen8vvq 57 28 including include VBG cord-354168-omen8vvq 57 29 low low JJ cord-354168-omen8vvq 57 30 - - HYPH cord-354168-omen8vvq 57 31 dose dose NN cord-354168-omen8vvq 57 32 CT CT NNP cord-354168-omen8vvq 57 33 skeletal skeletal JJ cord-354168-omen8vvq 57 34 survey survey NN cord-354168-omen8vvq 57 35 and and CC cord-354168-omen8vvq 57 36 PET pet NN cord-354168-omen8vvq 57 37 scans scan NNS cord-354168-omen8vvq 57 38 ) ) -RRB- cord-354168-omen8vvq 57 39 , , , cord-354168-omen8vvq 57 40 and and CC cord-354168-omen8vvq 57 41 the the DT cord-354168-omen8vvq 57 42 benefit benefit NN cord-354168-omen8vvq 57 43 of of IN cord-354168-omen8vvq 57 44 survival survival NN cord-354168-omen8vvq 57 45 in in IN cord-354168-omen8vvq 57 46 some some DT cord-354168-omen8vvq 57 47 patients patient NNS cord-354168-omen8vvq 57 48 could could MD cord-354168-omen8vvq 57 49 have have VB cord-354168-omen8vvq 57 50 been be VBN cord-354168-omen8vvq 57 51 due due JJ cord-354168-omen8vvq 57 52 to to IN cord-354168-omen8vvq 57 53 treating treat VBG cord-354168-omen8vvq 57 54 active active JJ cord-354168-omen8vvq 57 55 MM MM NNP cord-354168-omen8vvq 57 56 ( ( -LRB- cord-354168-omen8vvq 57 57 normal normal JJ cord-354168-omen8vvq 57 58 radiographs radiograph NNS cord-354168-omen8vvq 57 59 but but CC cord-354168-omen8vvq 57 60 abnormal abnormal JJ cord-354168-omen8vvq 57 61 PET pet NN cord-354168-omen8vvq 57 62 or or CC cord-354168-omen8vvq 57 63 MRI MRI NNP cord-354168-omen8vvq 57 64 ) ) -RRB- cord-354168-omen8vvq 57 65 , , , cord-354168-omen8vvq 57 66 rather rather RB cord-354168-omen8vvq 57 67 than than IN cord-354168-omen8vvq 57 68 SMM SMM NNP cord-354168-omen8vvq 57 69 . . . cord-354168-omen8vvq 58 1 In in IN cord-354168-omen8vvq 58 2 the the DT cord-354168-omen8vvq 58 3 second second JJ cord-354168-omen8vvq 58 4 trial trial NN cord-354168-omen8vvq 58 5 , , , cord-354168-omen8vvq 58 6 there there EX cord-354168-omen8vvq 58 7 is be VBZ cord-354168-omen8vvq 58 8 no no DT cord-354168-omen8vvq 58 9 OS OS NNP cord-354168-omen8vvq 58 10 benefit benefit NN cord-354168-omen8vvq 58 11 to to IN cord-354168-omen8vvq 58 12 date date NN cord-354168-omen8vvq 58 13 and and CC cord-354168-omen8vvq 58 14 only only RB cord-354168-omen8vvq 58 15 30 30 CD cord-354168-omen8vvq 58 16 % % NN cord-354168-omen8vvq 58 17 were be VBD cord-354168-omen8vvq 58 18 high high JJ cord-354168-omen8vvq 58 19 risk risk NN cord-354168-omen8vvq 58 20 according accord VBG cord-354168-omen8vvq 58 21 to to IN cord-354168-omen8vvq 58 22 the the DT cord-354168-omen8vvq 58 23 Mayo Mayo NNP cord-354168-omen8vvq 58 24 2018 2018 CD cord-354168-omen8vvq 58 25 risk risk NN cord-354168-omen8vvq 58 26 stratification stratification NN cord-354168-omen8vvq 58 27 [ [ -LRB- cord-354168-omen8vvq 58 28 20 20 CD cord-354168-omen8vvq 58 29 ] ] -RRB- cord-354168-omen8vvq 58 30 . . . cord-354168-omen8vvq 59 1 Also also RB cord-354168-omen8vvq 59 2 , , , cord-354168-omen8vvq 59 3 3.3 3.3 CD cord-354168-omen8vvq 59 4 % % NN cord-354168-omen8vvq 59 5 of of IN cord-354168-omen8vvq 59 6 patients patient NNS cord-354168-omen8vvq 59 7 had have VBD cord-354168-omen8vvq 59 8 bone bone NN cord-354168-omen8vvq 59 9 marrow marrow NN cord-354168-omen8vvq 59 10 plasma plasma NN cord-354168-omen8vvq 59 11 cells cell NNS cord-354168-omen8vvq 59 12 ≥60 ≥60 VBP cord-354168-omen8vvq 59 13 and and CC cord-354168-omen8vvq 59 14 8.2 8.2 CD cord-354168-omen8vvq 59 15 % % NN cord-354168-omen8vvq 59 16 had have VBD cord-354168-omen8vvq 59 17 serum serum NN cord-354168-omen8vvq 59 18 - - HYPH cord-354168-omen8vvq 59 19 free free JJ cord-354168-omen8vvq 59 20 light light JJ cord-354168-omen8vvq 59 21 chains chain NNS cord-354168-omen8vvq 59 22 > > XX cord-354168-omen8vvq 60 1 100 100 CD cord-354168-omen8vvq 60 2 mg mg NNP cord-354168-omen8vvq 60 3 / / SYM cord-354168-omen8vvq 60 4 dL dl NN cord-354168-omen8vvq 60 5 which which WDT cord-354168-omen8vvq 60 6 are be VBP cord-354168-omen8vvq 60 7 MM MM NNP cord-354168-omen8vvq 60 8 defining define VBG cord-354168-omen8vvq 60 9 events event NNS cord-354168-omen8vvq 60 10 by by IN cord-354168-omen8vvq 60 11 definition definition NN cord-354168-omen8vvq 60 12 [ [ -LRB- cord-354168-omen8vvq 60 13 20 20 CD cord-354168-omen8vvq 60 14 ] ] -RRB- cord-354168-omen8vvq 60 15 and and CC cord-354168-omen8vvq 60 16 these these DT cord-354168-omen8vvq 60 17 patients patient NNS cord-354168-omen8vvq 60 18 may may MD cord-354168-omen8vvq 60 19 have have VB cord-354168-omen8vvq 60 20 been be VBN cord-354168-omen8vvq 60 21 randomized randomize VBN cord-354168-omen8vvq 60 22 to to IN cord-354168-omen8vvq 60 23 no no DT cord-354168-omen8vvq 60 24 therapy therapy NN cord-354168-omen8vvq 60 25 . . . cord-354168-omen8vvq 61 1 We -PRON- PRP cord-354168-omen8vvq 61 2 currently currently RB cord-354168-omen8vvq 61 3 believe believe VBP cord-354168-omen8vvq 61 4 that that IN cord-354168-omen8vvq 61 5 involving involve VBG cord-354168-omen8vvq 61 6 patients patient NNS cord-354168-omen8vvq 61 7 in in IN cord-354168-omen8vvq 61 8 a a DT cord-354168-omen8vvq 61 9 clinical clinical JJ cord-354168-omen8vvq 61 10 trial trial NN cord-354168-omen8vvq 61 11 is be VBZ cord-354168-omen8vvq 61 12 the the DT cord-354168-omen8vvq 61 13 best good JJS cord-354168-omen8vvq 61 14 strategy strategy NN cord-354168-omen8vvq 61 15 for for IN cord-354168-omen8vvq 61 16 high high JJ cord-354168-omen8vvq 61 17 - - HYPH cord-354168-omen8vvq 61 18 risk risk NN cord-354168-omen8vvq 61 19 SMM SMM NNP cord-354168-omen8vvq 61 20 patients patient NNS cord-354168-omen8vvq 61 21 . . . cord-354168-omen8vvq 62 1 However however RB cord-354168-omen8vvq 62 2 , , , cord-354168-omen8vvq 62 3 with with IN cord-354168-omen8vvq 62 4 the the DT cord-354168-omen8vvq 62 5 current current JJ cord-354168-omen8vvq 62 6 COVID-19 COVID-19 NNP cord-354168-omen8vvq 62 7 pandemic pandemic NN cord-354168-omen8vvq 62 8 , , , cord-354168-omen8vvq 62 9 many many JJ cord-354168-omen8vvq 62 10 trials trial NNS cord-354168-omen8vvq 62 11 are be VBP cord-354168-omen8vvq 62 12 not not RB cord-354168-omen8vvq 62 13 accepting accept VBG cord-354168-omen8vvq 62 14 new new JJ cord-354168-omen8vvq 62 15 patients patient NNS cord-354168-omen8vvq 62 16 and and CC cord-354168-omen8vvq 62 17 we -PRON- PRP cord-354168-omen8vvq 62 18 would would MD cord-354168-omen8vvq 62 19 advise advise VB cord-354168-omen8vvq 62 20 close close JJ cord-354168-omen8vvq 62 21 monitoring monitoring NN cord-354168-omen8vvq 62 22 and and CC cord-354168-omen8vvq 62 23 observation observation NN cord-354168-omen8vvq 62 24 for for IN cord-354168-omen8vvq 62 25 these these DT cord-354168-omen8vvq 62 26 patients patient NNS cord-354168-omen8vvq 62 27 . . . cord-354168-omen8vvq 63 1 Risk risk NN cord-354168-omen8vvq 63 2 Stratification stratification NN cord-354168-omen8vvq 63 3 MM MM NNP cord-354168-omen8vvq 63 4 is be VBZ cord-354168-omen8vvq 63 5 a a DT cord-354168-omen8vvq 63 6 heterogeneous heterogeneous JJ cord-354168-omen8vvq 63 7 malignancy malignancy NN cord-354168-omen8vvq 63 8 and and CC cord-354168-omen8vvq 63 9 patients patient NNS cord-354168-omen8vvq 63 10 behave behave VBP cord-354168-omen8vvq 63 11 differently differently RB cord-354168-omen8vvq 63 12 . . . cord-354168-omen8vvq 64 1 Risk risk NN cord-354168-omen8vvq 64 2 stratification stratification NN cord-354168-omen8vvq 64 3 is be VBZ cord-354168-omen8vvq 64 4 critical critical JJ cord-354168-omen8vvq 64 5 , , , cord-354168-omen8vvq 64 6 especially especially RB cord-354168-omen8vvq 64 7 during during IN cord-354168-omen8vvq 64 8 the the DT cord-354168-omen8vvq 64 9 current current JJ cord-354168-omen8vvq 64 10 COVID-19 covid-19 JJ cord-354168-omen8vvq 64 11 situation situation NN cord-354168-omen8vvq 64 12 . . . cord-354168-omen8vvq 65 1 In in IN cord-354168-omen8vvq 65 2 general general JJ cord-354168-omen8vvq 65 3 , , , cord-354168-omen8vvq 65 4 patients patient NNS cord-354168-omen8vvq 65 5 with with IN cord-354168-omen8vvq 65 6 trisomies trisomy NNS cord-354168-omen8vvq 65 7 , , , cord-354168-omen8vvq 65 8 t(11 t(11 XX cord-354168-omen8vvq 65 9 ; ; : cord-354168-omen8vvq 65 10 14 14 CD cord-354168-omen8vvq 65 11 ) ) -RRB- cord-354168-omen8vvq 65 12 , , , cord-354168-omen8vvq 65 13 or or CC cord-354168-omen8vvq 65 14 t(6 t(6 NN cord-354168-omen8vvq 65 15 ; ; : cord-354168-omen8vvq 65 16 14 14 CD cord-354168-omen8vvq 65 17 ) ) -RRB- cord-354168-omen8vvq 65 18 are be VBP cord-354168-omen8vvq 65 19 considered consider VBN cord-354168-omen8vvq 65 20 standard standard JJ cord-354168-omen8vvq 65 21 risk risk NN cord-354168-omen8vvq 65 22 . . . cord-354168-omen8vvq 66 1 High high JJ cord-354168-omen8vvq 66 2 - - HYPH cord-354168-omen8vvq 66 3 risk risk NN cord-354168-omen8vvq 66 4 genetic genetic JJ cord-354168-omen8vvq 66 5 abnormalities abnormality NNS cord-354168-omen8vvq 66 6 include include VBP cord-354168-omen8vvq 66 7 t(4 t(4 NNP cord-354168-omen8vvq 66 8 ; ; : cord-354168-omen8vvq 66 9 14 14 CD cord-354168-omen8vvq 66 10 ) ) -RRB- cord-354168-omen8vvq 66 11 , , , cord-354168-omen8vvq 66 12 t(14 t(14 CD cord-354168-omen8vvq 66 13 ; ; : cord-354168-omen8vvq 66 14 16 16 CD cord-354168-omen8vvq 66 15 ) ) -RRB- cord-354168-omen8vvq 66 16 , , , cord-354168-omen8vvq 66 17 t(14 t(14 XX cord-354168-omen8vvq 66 18 ; ; : cord-354168-omen8vvq 66 19 20 20 CD cord-354168-omen8vvq 66 20 ) ) -RRB- cord-354168-omen8vvq 66 21 , , , cord-354168-omen8vvq 66 22 17p 17p NNP cord-354168-omen8vvq 66 23 del del NNP cord-354168-omen8vvq 66 24 , , , cord-354168-omen8vvq 66 25 1q+ 1q+ CD cord-354168-omen8vvq 66 26 and and CC cord-354168-omen8vvq 66 27 p53 p53 NN cord-354168-omen8vvq 66 28 mutations mutation NNS cord-354168-omen8vvq 66 29 . . . cord-354168-omen8vvq 67 1 The the DT cord-354168-omen8vvq 67 2 Revised revise VBN cord-354168-omen8vvq 67 3 International International NNP cord-354168-omen8vvq 67 4 Staging Staging NNP cord-354168-omen8vvq 67 5 System System NNP cord-354168-omen8vvq 67 6 ( ( -LRB- cord-354168-omen8vvq 67 7 R R NNP cord-354168-omen8vvq 67 8 - - HYPH cord-354168-omen8vvq 67 9 ISS ISS NNP cord-354168-omen8vvq 67 10 ) ) -RRB- cord-354168-omen8vvq 68 1 Acta Acta NNP cord-354168-omen8vvq 68 2 Haematol Haematol NNP cord-354168-omen8vvq 68 3 DOI DOI NNP cord-354168-omen8vvq 68 4 : : : cord-354168-omen8vvq 68 5 10.1159/000507690 10.1159/000507690 CD cord-354168-omen8vvq 68 6 [ [ -LRB- cord-354168-omen8vvq 68 7 21 21 CD cord-354168-omen8vvq 68 8 ] ] -RRB- cord-354168-omen8vvq 68 9 defines define VBZ cord-354168-omen8vvq 68 10 patients patient NNS cord-354168-omen8vvq 68 11 with with IN cord-354168-omen8vvq 68 12 stage stage NN cord-354168-omen8vvq 68 13 III III NNP cord-354168-omen8vvq 68 14 as as IN cord-354168-omen8vvq 68 15 high high JJ cord-354168-omen8vvq 68 16 risk risk NN cord-354168-omen8vvq 68 17 . . . cord-354168-omen8vvq 69 1 Patients patient NNS cord-354168-omen8vvq 69 2 with with IN cord-354168-omen8vvq 69 3 extramedullary extramedullary JJ cord-354168-omen8vvq 69 4 disease disease NN cord-354168-omen8vvq 69 5 are be VBP cord-354168-omen8vvq 69 6 also also RB cord-354168-omen8vvq 69 7 considered consider VBN cord-354168-omen8vvq 69 8 high high JJ cord-354168-omen8vvq 69 9 risk risk NN cord-354168-omen8vvq 69 10 . . . cord-354168-omen8vvq 70 1 We -PRON- PRP cord-354168-omen8vvq 70 2 consider consider VBP cord-354168-omen8vvq 70 3 patients patient NNS cord-354168-omen8vvq 70 4 with with IN cord-354168-omen8vvq 70 5 plasma plasma NN cord-354168-omen8vvq 70 6 cell cell NN cord-354168-omen8vvq 70 7 leukemia leukemia NN cord-354168-omen8vvq 70 8 ( ( -LRB- cord-354168-omen8vvq 70 9 PCL PCL NNP cord-354168-omen8vvq 70 10 ) ) -RRB- cord-354168-omen8vvq 70 11 as as IN cord-354168-omen8vvq 70 12 ultra ultra JJ cord-354168-omen8vvq 70 13 - - JJ cord-354168-omen8vvq 70 14 high high JJ cord-354168-omen8vvq 70 15 risk risk NN cord-354168-omen8vvq 70 16 . . . cord-354168-omen8vvq 71 1 We -PRON- PRP cord-354168-omen8vvq 71 2 recommend recommend VBP cord-354168-omen8vvq 71 3 screening screen VBG cord-354168-omen8vvq 71 4 all all DT cord-354168-omen8vvq 71 5 patients patient NNS cord-354168-omen8vvq 71 6 with with IN cord-354168-omen8vvq 71 7 newly newly RB cord-354168-omen8vvq 71 8 diagnosed diagnose VBN cord-354168-omen8vvq 71 9 MM MM NNP cord-354168-omen8vvq 71 10 for for IN cord-354168-omen8vvq 71 11 COVID-19 COVID-19 NNP cord-354168-omen8vvq 71 12 before before IN cord-354168-omen8vvq 71 13 starting start VBG cord-354168-omen8vvq 71 14 therapy therapy NN cord-354168-omen8vvq 71 15 , , , cord-354168-omen8vvq 71 16 as as IN cord-354168-omen8vvq 71 17 treatment treatment NN cord-354168-omen8vvq 71 18 for for IN cord-354168-omen8vvq 71 19 MM MM NNP cord-354168-omen8vvq 71 20 can can MD cord-354168-omen8vvq 71 21 aggravate aggravate VB cord-354168-omen8vvq 71 22 the the DT cord-354168-omen8vvq 71 23 adverse adverse JJ cord-354168-omen8vvq 71 24 events event NNS cord-354168-omen8vvq 71 25 of of IN cord-354168-omen8vvq 71 26 an an DT cord-354168-omen8vvq 71 27 active active JJ cord-354168-omen8vvq 71 28 COVID-19 covid-19 CD cord-354168-omen8vvq 71 29 infection infection NN cord-354168-omen8vvq 71 30 . . . cord-354168-omen8vvq 72 1 Screening screening NN cord-354168-omen8vvq 72 2 should should MD cord-354168-omen8vvq 72 3 be be VB cord-354168-omen8vvq 72 4 done do VBN cord-354168-omen8vvq 72 5 for for IN cord-354168-omen8vvq 72 6 outpatients outpatient NNS cord-354168-omen8vvq 72 7 as as RB cord-354168-omen8vvq 72 8 well well RB cord-354168-omen8vvq 72 9 as as IN cord-354168-omen8vvq 72 10 inpatients inpatient NNS cord-354168-omen8vvq 72 11 initiating initiate VBG cord-354168-omen8vvq 72 12 therapy therapy NN cord-354168-omen8vvq 72 13 . . . cord-354168-omen8vvq 73 1 For for IN cord-354168-omen8vvq 73 2 patients patient NNS cord-354168-omen8vvq 73 3 testing test VBG cord-354168-omen8vvq 73 4 positive positive JJ cord-354168-omen8vvq 73 5 for for IN cord-354168-omen8vvq 73 6 COVID-19 covid-19 NN cord-354168-omen8vvq 73 7 we -PRON- PRP cord-354168-omen8vvq 73 8 recommend recommend VBP cord-354168-omen8vvq 73 9 holding hold VBG cord-354168-omen8vvq 73 10 treatment treatment NN cord-354168-omen8vvq 73 11 until until IN cord-354168-omen8vvq 73 12 they -PRON- PRP cord-354168-omen8vvq 73 13 have have VBP cord-354168-omen8vvq 73 14 convalesced convalesce VBN cord-354168-omen8vvq 73 15 from from IN cord-354168-omen8vvq 73 16 acute acute JJ cord-354168-omen8vvq 73 17 illness illness NN cord-354168-omen8vvq 73 18 . . . cord-354168-omen8vvq 74 1 Metabolic metabolic JJ cord-354168-omen8vvq 74 2 and and CC cord-354168-omen8vvq 74 3 bone bone NN cord-354168-omen8vvq 74 4 - - HYPH cord-354168-omen8vvq 74 5 related relate VBN cord-354168-omen8vvq 74 6 acute acute JJ cord-354168-omen8vvq 74 7 complications complication NNS cord-354168-omen8vvq 74 8 can can MD cord-354168-omen8vvq 74 9 be be VB cord-354168-omen8vvq 74 10 best well RBS cord-354168-omen8vvq 74 11 managed manage VBN cord-354168-omen8vvq 74 12 with with IN cord-354168-omen8vvq 74 13 supportive supportive JJ cord-354168-omen8vvq 74 14 care care NN cord-354168-omen8vvq 74 15 . . . cord-354168-omen8vvq 75 1 Prevention prevention NN cord-354168-omen8vvq 75 2 is be VBZ cord-354168-omen8vvq 75 3 the the DT cord-354168-omen8vvq 75 4 best good JJS cord-354168-omen8vvq 75 5 cure cure NN cord-354168-omen8vvq 75 6 . . . cord-354168-omen8vvq 76 1 We -PRON- PRP cord-354168-omen8vvq 76 2 stress stress VBP cord-354168-omen8vvq 76 3 educating educate VBG cord-354168-omen8vvq 76 4 the the DT cord-354168-omen8vvq 76 5 patient patient NN cord-354168-omen8vvq 76 6 about about IN cord-354168-omen8vvq 76 7 the the DT cord-354168-omen8vvq 76 8 impact impact NN cord-354168-omen8vvq 76 9 of of IN cord-354168-omen8vvq 76 10 COVID-19 COVID-19 NNP cord-354168-omen8vvq 76 11 on on IN cord-354168-omen8vvq 76 12 their -PRON- PRP$ cord-354168-omen8vvq 76 13 health health NN cord-354168-omen8vvq 76 14 , , , cord-354168-omen8vvq 76 15 emphasizing emphasize VBG cord-354168-omen8vvq 76 16 the the DT cord-354168-omen8vvq 76 17 weak weak JJ cord-354168-omen8vvq 76 18 immune immune JJ cord-354168-omen8vvq 76 19 system system NN cord-354168-omen8vvq 76 20 in in IN cord-354168-omen8vvq 76 21 patients patient NNS cord-354168-omen8vvq 76 22 with with IN cord-354168-omen8vvq 76 23 MM MM NNP cord-354168-omen8vvq 76 24 . . . cord-354168-omen8vvq 77 1 Social social JJ cord-354168-omen8vvq 77 2 distancing distancing NN cord-354168-omen8vvq 77 3 , , , cord-354168-omen8vvq 77 4 staying stay VBG cord-354168-omen8vvq 77 5 home home RB cord-354168-omen8vvq 77 6 ( ( -LRB- cord-354168-omen8vvq 77 7 except except IN cord-354168-omen8vvq 77 8 for for IN cord-354168-omen8vvq 77 9 treatment treatment NN cord-354168-omen8vvq 77 10 ) ) -RRB- cord-354168-omen8vvq 77 11 , , , cord-354168-omen8vvq 77 12 washing wash VBG cord-354168-omen8vvq 77 13 hands hand NNS cord-354168-omen8vvq 77 14 frequently frequently RB cord-354168-omen8vvq 77 15 with with IN cord-354168-omen8vvq 77 16 soap soap NN cord-354168-omen8vvq 77 17 ( ( -LRB- cord-354168-omen8vvq 77 18 for for IN cord-354168-omen8vvq 77 19 at at RB cord-354168-omen8vvq 77 20 least least JJS cord-354168-omen8vvq 77 21 20 20 CD cord-354168-omen8vvq 77 22 s s NNS cord-354168-omen8vvq 77 23 ) ) -RRB- cord-354168-omen8vvq 77 24 , , , cord-354168-omen8vvq 77 25 covering cover VBG cord-354168-omen8vvq 77 26 coughs cough NNS cord-354168-omen8vvq 77 27 and and CC cord-354168-omen8vvq 77 28 sneezes sneeze VBZ cord-354168-omen8vvq 77 29 with with IN cord-354168-omen8vvq 77 30 tissue tissue NN cord-354168-omen8vvq 77 31 or or CC cord-354168-omen8vvq 77 32 using use VBG cord-354168-omen8vvq 77 33 the the DT cord-354168-omen8vvq 77 34 elbow elbow NN cord-354168-omen8vvq 77 35 , , , cord-354168-omen8vvq 77 36 and and CC cord-354168-omen8vvq 77 37 cleaning clean VBG cord-354168-omen8vvq 77 38 frequently frequently RB cord-354168-omen8vvq 77 39 touched touch VBN cord-354168-omen8vvq 77 40 surfaces surface NNS cord-354168-omen8vvq 77 41 are be VBP cord-354168-omen8vvq 77 42 recommended recommend VBN cord-354168-omen8vvq 77 43 [ [ -LRB- cord-354168-omen8vvq 77 44 22 22 CD cord-354168-omen8vvq 77 45 ] ] -RRB- cord-354168-omen8vvq 77 46 . . . cord-354168-omen8vvq 78 1 Family family NN cord-354168-omen8vvq 78 2 members member NNS cord-354168-omen8vvq 78 3 are be VBP cord-354168-omen8vvq 78 4 critical critical JJ cord-354168-omen8vvq 78 5 for for IN cord-354168-omen8vvq 78 6 patient patient JJ cord-354168-omen8vvq 78 7 care care NN cord-354168-omen8vvq 78 8 and and CC cord-354168-omen8vvq 78 9 their -PRON- PRP$ cord-354168-omen8vvq 78 10 mental mental JJ cord-354168-omen8vvq 78 11 health health NN cord-354168-omen8vvq 78 12 is be VBZ cord-354168-omen8vvq 78 13 important important JJ cord-354168-omen8vvq 78 14 . . . cord-354168-omen8vvq 79 1 Social social JJ cord-354168-omen8vvq 79 2 support support NN cord-354168-omen8vvq 79 3 including include VBG cord-354168-omen8vvq 79 4 tips tip NNS cord-354168-omen8vvq 79 5 for for IN cord-354168-omen8vvq 79 6 coping cope VBG cord-354168-omen8vvq 79 7 with with IN cord-354168-omen8vvq 79 8 stress stress NN cord-354168-omen8vvq 79 9 should should MD cord-354168-omen8vvq 79 10 be be VB cord-354168-omen8vvq 79 11 provided provide VBN cord-354168-omen8vvq 79 12 to to IN cord-354168-omen8vvq 79 13 the the DT cord-354168-omen8vvq 79 14 patient patient NN cord-354168-omen8vvq 79 15 and and CC cord-354168-omen8vvq 79 16 their -PRON- PRP$ cord-354168-omen8vvq 79 17 family family NN cord-354168-omen8vvq 79 18 members member NNS cord-354168-omen8vvq 79 19 . . . cord-354168-omen8vvq 80 1 We -PRON- PRP cord-354168-omen8vvq 80 2 find find VBP cord-354168-omen8vvq 80 3 the the DT cord-354168-omen8vvq 80 4 following follow VBG cord-354168-omen8vvq 80 5 website website NN cord-354168-omen8vvq 80 6 ( ( -LRB- cord-354168-omen8vvq 80 7 https://suicidepreventionlifeline.org/current-events/ https://suicidepreventionlifeline.org/current-events/ NN cord-354168-omen8vvq 80 8 supporting support VBG cord-354168-omen8vvq 80 9 - - HYPH cord-354168-omen8vvq 80 10 your -PRON- PRP$ cord-354168-omen8vvq 80 11 - - HYPH cord-354168-omen8vvq 80 12 emotional emotional JJ cord-354168-omen8vvq 80 13 - - HYPH cord-354168-omen8vvq 80 14 well well RB cord-354168-omen8vvq 80 15 - - HYPH cord-354168-omen8vvq 80 16 being be VBG cord-354168-omen8vvq 80 17 - - HYPH cord-354168-omen8vvq 80 18 during during IN cord-354168-omen8vvq 80 19 - - HYPH cord-354168-omen8vvq 80 20 the the DT cord-354168-omen8vvq 80 21 - - HYPH cord-354168-omen8vvq 80 22 covid-19-outbreak/ covid-19-outbreak/ NN cord-354168-omen8vvq 80 23 ) ) -RRB- cord-354168-omen8vvq 80 24 useful useful JJ cord-354168-omen8vvq 80 25 in in IN cord-354168-omen8vvq 80 26 providing provide VBG cord-354168-omen8vvq 80 27 recommendations recommendation NNS cord-354168-omen8vvq 80 28 regarding regard VBG cord-354168-omen8vvq 80 29 coping cope VBG cord-354168-omen8vvq 80 30 with with IN cord-354168-omen8vvq 80 31 the the DT cord-354168-omen8vvq 80 32 current current JJ cord-354168-omen8vvq 80 33 pandemic pandemic NN cord-354168-omen8vvq 80 34 [ [ -LRB- cord-354168-omen8vvq 80 35 23 23 CD cord-354168-omen8vvq 80 36 ] ] -RRB- cord-354168-omen8vvq 80 37 . . . cord-354168-omen8vvq 81 1 For for IN cord-354168-omen8vvq 81 2 Standard standard JJ cord-354168-omen8vvq 81 3 - - HYPH cord-354168-omen8vvq 81 4 Risk risk NN cord-354168-omen8vvq 81 5 Patients patient NNS cord-354168-omen8vvq 81 6 We -PRON- PRP cord-354168-omen8vvq 81 7 believe believe VBP cord-354168-omen8vvq 81 8 that that IN cord-354168-omen8vvq 81 9 these these DT cord-354168-omen8vvq 81 10 patients patient NNS cord-354168-omen8vvq 81 11 could could MD cord-354168-omen8vvq 81 12 be be VB cord-354168-omen8vvq 81 13 managed manage VBN cord-354168-omen8vvq 81 14 using use VBG cord-354168-omen8vvq 81 15 oral oral JJ cord-354168-omen8vvq 81 16 drugs drug NNS cord-354168-omen8vvq 81 17 to to TO cord-354168-omen8vvq 81 18 decrease decrease VB cord-354168-omen8vvq 81 19 the the DT cord-354168-omen8vvq 81 20 risk risk NN cord-354168-omen8vvq 81 21 of of IN cord-354168-omen8vvq 81 22 weekly weekly JJ cord-354168-omen8vvq 81 23 hospital hospital NN cord-354168-omen8vvq 81 24 visits visit NNS cord-354168-omen8vvq 81 25 and and CC cord-354168-omen8vvq 81 26 exposures exposure NNS cord-354168-omen8vvq 81 27 . . . cord-354168-omen8vvq 82 1 We -PRON- PRP cord-354168-omen8vvq 82 2 recommend recommend VBP cord-354168-omen8vvq 82 3 ixazomib ixazomib JJ cord-354168-omen8vvq 82 4 , , , cord-354168-omen8vvq 82 5 lenalidomide lenalidomide NN cord-354168-omen8vvq 82 6 , , , cord-354168-omen8vvq 82 7 and and CC cord-354168-omen8vvq 82 8 dexamethasone dexamethasone NN cord-354168-omen8vvq 82 9 ( ( -LRB- cord-354168-omen8vvq 82 10 IRd IRd NNP cord-354168-omen8vvq 82 11 ) ) -RRB- cord-354168-omen8vvq 82 12 given give VBN cord-354168-omen8vvq 82 13 over over RP cord-354168-omen8vvq 82 14 a a DT cord-354168-omen8vvq 82 15 28-day 28-day CD cord-354168-omen8vvq 82 16 cycle cycle NN cord-354168-omen8vvq 82 17 . . . cord-354168-omen8vvq 83 1 Lenalidomide Lenalidomide NNP cord-354168-omen8vvq 83 2 should should MD cord-354168-omen8vvq 83 3 be be VB cord-354168-omen8vvq 83 4 given give VBN cord-354168-omen8vvq 83 5 at at IN cord-354168-omen8vvq 83 6 a a DT cord-354168-omen8vvq 83 7 dose dose NN cord-354168-omen8vvq 83 8 of of IN cord-354168-omen8vvq 83 9 25 25 CD cord-354168-omen8vvq 83 10 mg mg NNP cord-354168-omen8vvq 83 11 p.o p.o NNP cord-354168-omen8vvq 83 12 . . NNP cord-354168-omen8vvq 83 13 daily daily RB cord-354168-omen8vvq 83 14 on on IN cord-354168-omen8vvq 83 15 days day NNS cord-354168-omen8vvq 83 16 1 1 CD cord-354168-omen8vvq 83 17 - - SYM cord-354168-omen8vvq 83 18 21 21 CD cord-354168-omen8vvq 83 19 and and CC cord-354168-omen8vvq 83 20 ixazomib ixazomib NNP cord-354168-omen8vvq 83 21 at at IN cord-354168-omen8vvq 83 22 a a DT cord-354168-omen8vvq 83 23 dose dose NN cord-354168-omen8vvq 83 24 of of IN cord-354168-omen8vvq 83 25 4 4 CD cord-354168-omen8vvq 83 26 mg mg NNP cord-354168-omen8vvq 83 27 p.o p.o NNP cord-354168-omen8vvq 83 28 . . . cord-354168-omen8vvq 84 1 on on IN cord-354168-omen8vvq 84 2 days day NNS cord-354168-omen8vvq 84 3 1 1 CD cord-354168-omen8vvq 84 4 , , , cord-354168-omen8vvq 84 5 8 8 CD cord-354168-omen8vvq 84 6 , , , cord-354168-omen8vvq 84 7 and and CC cord-354168-omen8vvq 84 8 15 15 CD cord-354168-omen8vvq 84 9 . . . cord-354168-omen8vvq 85 1 We -PRON- PRP cord-354168-omen8vvq 85 2 recommend recommend VBP cord-354168-omen8vvq 85 3 decreasing decrease VBG cord-354168-omen8vvq 85 4 the the DT cord-354168-omen8vvq 85 5 dose dose NN cord-354168-omen8vvq 85 6 of of IN cord-354168-omen8vvq 85 7 dexamethasone dexamethasone NN cord-354168-omen8vvq 85 8 to to IN cord-354168-omen8vvq 85 9 20 20 CD cord-354168-omen8vvq 85 10 mg mg NNP cord-354168-omen8vvq 85 11 p.o p.o NNP cord-354168-omen8vvq 85 12 . . NNP cord-354168-omen8vvq 85 13 weekly weekly NNP cord-354168-omen8vvq 85 14 to to TO cord-354168-omen8vvq 85 15 decrease decrease VB cord-354168-omen8vvq 85 16 the the DT cord-354168-omen8vvq 85 17 risk risk NN cord-354168-omen8vvq 85 18 of of IN cord-354168-omen8vvq 85 19 infection infection NN cord-354168-omen8vvq 85 20 . . . cord-354168-omen8vvq 86 1 We -PRON- PRP cord-354168-omen8vvq 86 2 understand understand VBP cord-354168-omen8vvq 86 3 that that IN cord-354168-omen8vvq 86 4 the the DT cord-354168-omen8vvq 86 5 IRd IRd NNP cord-354168-omen8vvq 86 6 regimen regimen NN cord-354168-omen8vvq 86 7 has have VBZ cord-354168-omen8vvq 86 8 not not RB cord-354168-omen8vvq 86 9 been be VBN cord-354168-omen8vvq 86 10 compared compare VBN cord-354168-omen8vvq 86 11 head head NN cord-354168-omen8vvq 86 12 to to TO cord-354168-omen8vvq 86 13 head head VB cord-354168-omen8vvq 86 14 with with IN cord-354168-omen8vvq 86 15 known know VBN cord-354168-omen8vvq 86 16 standard standard JJ cord-354168-omen8vvq 86 17 therapy therapy NN cord-354168-omen8vvq 86 18 , , , cord-354168-omen8vvq 86 19 but but CC cord-354168-omen8vvq 86 20 the the DT cord-354168-omen8vvq 86 21 response response NN cord-354168-omen8vvq 86 22 rate rate NN cord-354168-omen8vvq 86 23 from from IN cord-354168-omen8vvq 86 24 the the DT cord-354168-omen8vvq 86 25 phase phase NN cord-354168-omen8vvq 86 26 1/2 1/2 CD cord-354168-omen8vvq 86 27 trial trial NN cord-354168-omen8vvq 86 28 is be VBZ cord-354168-omen8vvq 86 29 comparable comparable JJ cord-354168-omen8vvq 86 30 [ [ -LRB- cord-354168-omen8vvq 86 31 24 24 CD cord-354168-omen8vvq 86 32 ] ] -RRB- cord-354168-omen8vvq 86 33 and and CC cord-354168-omen8vvq 86 34 in in IN cord-354168-omen8vvq 86 35 our -PRON- PRP$ cord-354168-omen8vvq 86 36 opinion opinion NN cord-354168-omen8vvq 86 37 using use VBG cord-354168-omen8vvq 86 38 an an DT cord-354168-omen8vvq 86 39 oral oral JJ cord-354168-omen8vvq 86 40 regimen regimen NN cord-354168-omen8vvq 86 41 will will MD cord-354168-omen8vvq 86 42 help help VB cord-354168-omen8vvq 86 43 in in IN cord-354168-omen8vvq 86 44 decreasing decrease VBG cord-354168-omen8vvq 86 45 the the DT cord-354168-omen8vvq 86 46 exposure exposure NN cord-354168-omen8vvq 86 47 to to IN cord-354168-omen8vvq 86 48 and and CC cord-354168-omen8vvq 86 49 infection infection NN cord-354168-omen8vvq 86 50 with with IN cord-354168-omen8vvq 86 51 CO co NN cord-354168-omen8vvq 86 52 - - NN cord-354168-omen8vvq 86 53 VID-19 VID-19 NNP cord-354168-omen8vvq 86 54 . . . cord-354168-omen8vvq 87 1 Another another DT cord-354168-omen8vvq 87 2 possible possible JJ cord-354168-omen8vvq 87 3 combination combination NN cord-354168-omen8vvq 87 4 is be VBZ cord-354168-omen8vvq 87 5 cyclophosphamide cyclophosphamide JJ cord-354168-omen8vvq 87 6 lenalidomide lenalidomide NN cord-354168-omen8vvq 87 7 and and CC cord-354168-omen8vvq 87 8 dexamethasone dexamethasone NN cord-354168-omen8vvq 87 9 ( ( -LRB- cord-354168-omen8vvq 87 10 CRd CRd NNP cord-354168-omen8vvq 87 11 ) ) -RRB- cord-354168-omen8vvq 87 12 given give VBN cord-354168-omen8vvq 87 13 over over IN cord-354168-omen8vvq 87 14 a a DT cord-354168-omen8vvq 87 15 28day 28day NN cord-354168-omen8vvq 87 16 cycle cycle NN cord-354168-omen8vvq 87 17 [ [ -LRB- cord-354168-omen8vvq 87 18 25 25 CD cord-354168-omen8vvq 87 19 ] ] -RRB- cord-354168-omen8vvq 87 20 with with IN cord-354168-omen8vvq 87 21 cyclophosphamide cyclophosphamide NN cord-354168-omen8vvq 87 22 ( ( -LRB- cord-354168-omen8vvq 87 23 300 300 CD cord-354168-omen8vvq 87 24 mg mg NNP cord-354168-omen8vvq 87 25 / / SYM cord-354168-omen8vvq 87 26 m m NNP cord-354168-omen8vvq 87 27 2 2 CD cord-354168-omen8vvq 87 28 p.o p.o NNP cord-354168-omen8vvq 87 29 . . . cord-354168-omen8vvq 88 1 on on IN cord-354168-omen8vvq 88 2 days day NNS cord-354168-omen8vvq 88 3 1 1 CD cord-354168-omen8vvq 88 4 , , , cord-354168-omen8vvq 88 5 8 8 CD cord-354168-omen8vvq 88 6 , , , cord-354168-omen8vvq 88 7 and and CC cord-354168-omen8vvq 88 8 15 15 CD cord-354168-omen8vvq 88 9 ) ) -RRB- cord-354168-omen8vvq 88 10 , , , cord-354168-omen8vvq 88 11 lenalidomide lenalidomide NNP cord-354168-omen8vvq 88 12 ( ( -LRB- cord-354168-omen8vvq 88 13 25 25 CD cord-354168-omen8vvq 88 14 mg mg NNP cord-354168-omen8vvq 88 15 p.o p.o NNP cord-354168-omen8vvq 88 16 . . . cord-354168-omen8vvq 89 1 on on IN cord-354168-omen8vvq 89 2 days day NNS cord-354168-omen8vvq 89 3 , , , cord-354168-omen8vvq 89 4 and and CC cord-354168-omen8vvq 89 5 dexamethasone dexamethasone NN cord-354168-omen8vvq 89 6 ( ( -LRB- cord-354168-omen8vvq 89 7 20 20 CD cord-354168-omen8vvq 89 8 mg mg NNP cord-354168-omen8vvq 89 9 p.o p.o NNP cord-354168-omen8vvq 89 10 . . NNP cord-354168-omen8vvq 89 11 daily daily RB cord-354168-omen8vvq 89 12 once once RB cord-354168-omen8vvq 89 13 weekly weekly RB cord-354168-omen8vvq 89 14 ) ) -RRB- cord-354168-omen8vvq 89 15 . . . cord-354168-omen8vvq 90 1 A a DT cord-354168-omen8vvq 90 2 third third JJ cord-354168-omen8vvq 90 3 alternative alternative NN cord-354168-omen8vvq 90 4 is be VBZ cord-354168-omen8vvq 90 5 daratumumab daratumumab VBN cord-354168-omen8vvq 90 6 lenalidomide lenalidomide NN cord-354168-omen8vvq 90 7 and and CC cord-354168-omen8vvq 90 8 dexamethasone dexamethasone NN cord-354168-omen8vvq 90 9 ( ( -LRB- cord-354168-omen8vvq 90 10 DRd DRd NNS cord-354168-omen8vvq 90 11 ) ) -RRB- cord-354168-omen8vvq 90 12 given give VBN cord-354168-omen8vvq 90 13 over over RP cord-354168-omen8vvq 90 14 a a DT cord-354168-omen8vvq 90 15 28-day 28-day CD cord-354168-omen8vvq 90 16 cycle cycle NN cord-354168-omen8vvq 90 17 [ [ -LRB- cord-354168-omen8vvq 90 18 26 26 CD cord-354168-omen8vvq 90 19 ] ] -RRB- cord-354168-omen8vvq 90 20 . . . cord-354168-omen8vvq 91 1 Full full JJ cord-354168-omen8vvq 91 2 doses dose NNS cord-354168-omen8vvq 91 3 of of IN cord-354168-omen8vvq 91 4 daratumumab daratumumab NNP cord-354168-omen8vvq 91 5 and and CC cord-354168-omen8vvq 91 6 lenalidomide lenalidomide NN cord-354168-omen8vvq 91 7 should should MD cord-354168-omen8vvq 91 8 be be VB cord-354168-omen8vvq 91 9 given give VBN cord-354168-omen8vvq 91 10 . . . cord-354168-omen8vvq 92 1 We -PRON- PRP cord-354168-omen8vvq 92 2 would would MD cord-354168-omen8vvq 92 3 recommend recommend VB cord-354168-omen8vvq 92 4 that that IN cord-354168-omen8vvq 92 5 the the DT cord-354168-omen8vvq 92 6 first first JJ cord-354168-omen8vvq 92 7 dose dose NN cord-354168-omen8vvq 92 8 of of IN cord-354168-omen8vvq 92 9 dexamethasone dexamethasone NN cord-354168-omen8vvq 92 10 is be VBZ cord-354168-omen8vvq 92 11 40 40 CD cord-354168-omen8vvq 92 12 mg mg NNP cord-354168-omen8vvq 92 13 p.o p.o NNP cord-354168-omen8vvq 92 14 . . NNP cord-354168-omen8vvq 92 15 to to TO cord-354168-omen8vvq 92 16 decrease decrease VB cord-354168-omen8vvq 92 17 the the DT cord-354168-omen8vvq 92 18 risk risk NN cord-354168-omen8vvq 92 19 of of IN cord-354168-omen8vvq 92 20 infusionrelated infusionrelated JJ cord-354168-omen8vvq 92 21 reaction reaction NN cord-354168-omen8vvq 92 22 to to IN cord-354168-omen8vvq 92 23 daratumumab daratumumab NNP cord-354168-omen8vvq 92 24 . . . cord-354168-omen8vvq 93 1 We -PRON- PRP cord-354168-omen8vvq 93 2 would would MD cord-354168-omen8vvq 93 3 recommend recommend VB cord-354168-omen8vvq 93 4 giving give VBG cord-354168-omen8vvq 93 5 dexamethasone dexamethasone NN cord-354168-omen8vvq 93 6 orally orally RB cord-354168-omen8vvq 93 7 , , , cord-354168-omen8vvq 93 8 rather rather RB cord-354168-omen8vvq 93 9 than than IN cord-354168-omen8vvq 93 10 intravenously intravenously RB cord-354168-omen8vvq 93 11 , , , cord-354168-omen8vvq 93 12 to to TO cord-354168-omen8vvq 93 13 decrease decrease VB cord-354168-omen8vvq 93 14 the the DT cord-354168-omen8vvq 93 15 total total JJ cord-354168-omen8vvq 93 16 time time NN cord-354168-omen8vvq 93 17 in in IN cord-354168-omen8vvq 93 18 the the DT cord-354168-omen8vvq 93 19 chemotherapy chemotherapy NN cord-354168-omen8vvq 93 20 unit unit NN cord-354168-omen8vvq 93 21 for for IN cord-354168-omen8vvq 93 22 the the DT cord-354168-omen8vvq 93 23 patient patient NN cord-354168-omen8vvq 93 24 . . . cord-354168-omen8vvq 94 1 The the DT cord-354168-omen8vvq 94 2 dose dose NN cord-354168-omen8vvq 94 3 of of IN cord-354168-omen8vvq 94 4 dexamethasone dexamethasone NN cord-354168-omen8vvq 94 5 can can MD cord-354168-omen8vvq 94 6 be be VB cord-354168-omen8vvq 94 7 decreased decrease VBN cord-354168-omen8vvq 94 8 during during IN cord-354168-omen8vvq 94 9 subsequent subsequent JJ cord-354168-omen8vvq 94 10 cycles cycle NNS cord-354168-omen8vvq 94 11 , , , cord-354168-omen8vvq 94 12 if if IN cord-354168-omen8vvq 94 13 no no DT cord-354168-omen8vvq 94 14 infusion infusion NN cord-354168-omen8vvq 94 15 reaction reaction NN cord-354168-omen8vvq 94 16 is be VBZ cord-354168-omen8vvq 94 17 documented document VBN cord-354168-omen8vvq 94 18 . . . cord-354168-omen8vvq 95 1 If if IN cord-354168-omen8vvq 95 2 no no DT cord-354168-omen8vvq 95 3 infusion infusion NN cord-354168-omen8vvq 95 4 reactions reaction NNS cord-354168-omen8vvq 95 5 occur occur VBP cord-354168-omen8vvq 95 6 , , , cord-354168-omen8vvq 95 7 the the DT cord-354168-omen8vvq 95 8 interval interval NN cord-354168-omen8vvq 95 9 for for IN cord-354168-omen8vvq 95 10 daratumumab daratumumab NNP cord-354168-omen8vvq 95 11 infusion infusion NN cord-354168-omen8vvq 95 12 can can MD cord-354168-omen8vvq 95 13 be be VB cord-354168-omen8vvq 95 14 decreased decrease VBN cord-354168-omen8vvq 95 15 to to IN cord-354168-omen8vvq 95 16 90 90 CD cord-354168-omen8vvq 95 17 min min NN cord-354168-omen8vvq 95 18 . . . cord-354168-omen8vvq 96 1 We -PRON- PRP cord-354168-omen8vvq 96 2 understand understand VBP cord-354168-omen8vvq 96 3 that that IN cord-354168-omen8vvq 96 4 not not RB cord-354168-omen8vvq 96 5 all all DT cord-354168-omen8vvq 96 6 patients patient NNS cord-354168-omen8vvq 96 7 can can MD cord-354168-omen8vvq 96 8 access access VB cord-354168-omen8vvq 96 9 these these DT cord-354168-omen8vvq 96 10 medications medication NNS cord-354168-omen8vvq 96 11 . . . cord-354168-omen8vvq 97 1 In in IN cord-354168-omen8vvq 97 2 that that DT cord-354168-omen8vvq 97 3 case case NN cord-354168-omen8vvq 97 4 , , , cord-354168-omen8vvq 97 5 standard standard NN cord-354168-omen8vvq 97 6 of of IN cord-354168-omen8vvq 97 7 care care NN cord-354168-omen8vvq 97 8 therapy therapy NN cord-354168-omen8vvq 97 9 using use VBG cord-354168-omen8vvq 97 10 lenalidomide lenalidomide NN cord-354168-omen8vvq 97 11 , , , cord-354168-omen8vvq 97 12 bortezomib bortezomib NNP cord-354168-omen8vvq 97 13 , , , cord-354168-omen8vvq 97 14 and and CC cord-354168-omen8vvq 97 15 dexamethasone dexamethasone NN cord-354168-omen8vvq 97 16 ( ( -LRB- cord-354168-omen8vvq 97 17 RVd rvd NN cord-354168-omen8vvq 97 18 ) ) -RRB- cord-354168-omen8vvq 97 19 should should MD cord-354168-omen8vvq 97 20 be be VB cord-354168-omen8vvq 97 21 considered consider VBN cord-354168-omen8vvq 97 22 . . . cord-354168-omen8vvq 98 1 We -PRON- PRP cord-354168-omen8vvq 98 2 would would MD cord-354168-omen8vvq 98 3 recommend recommend VB cord-354168-omen8vvq 98 4 RVd rvd WDT cord-354168-omen8vvq 98 5 over over IN cord-354168-omen8vvq 98 6 28 28 CD cord-354168-omen8vvq 98 7 days day NNS cord-354168-omen8vvq 98 8 with with IN cord-354168-omen8vvq 98 9 lenalidomide lenalidomide NN cord-354168-omen8vvq 98 10 ( ( -LRB- cord-354168-omen8vvq 98 11 25 25 CD cord-354168-omen8vvq 98 12 mg mg NNP cord-354168-omen8vvq 98 13 p.o p.o NNP cord-354168-omen8vvq 98 14 . . . cord-354168-omen8vvq 99 1 on on IN cord-354168-omen8vvq 99 2 days day NNS cord-354168-omen8vvq 99 3 1 1 CD cord-354168-omen8vvq 99 4 - - SYM cord-354168-omen8vvq 99 5 21 21 CD cord-354168-omen8vvq 99 6 ) ) -RRB- cord-354168-omen8vvq 99 7 , , , cord-354168-omen8vvq 99 8 bortezomib bortezomib NNP cord-354168-omen8vvq 99 9 ( ( -LRB- cord-354168-omen8vvq 99 10 1.5 1.5 CD cord-354168-omen8vvq 99 11 mg mg NNP cord-354168-omen8vvq 99 12 / / SYM cord-354168-omen8vvq 99 13 m m NNP cord-354168-omen8vvq 99 14 2 2 CD cord-354168-omen8vvq 99 15 s.c s.c NNP cord-354168-omen8vvq 99 16 . . . cord-354168-omen8vvq 100 1 on on IN cord-354168-omen8vvq 100 2 days day NNS cord-354168-omen8vvq 100 3 1 1 CD cord-354168-omen8vvq 100 4 , , , cord-354168-omen8vvq 100 5 8 8 CD cord-354168-omen8vvq 100 6 , , , cord-354168-omen8vvq 100 7 and15 and15 CD cord-354168-omen8vvq 100 8 ) ) -RRB- cord-354168-omen8vvq 100 9 , , , cord-354168-omen8vvq 100 10 and and CC cord-354168-omen8vvq 100 11 dexamethasone dexamethasone NN cord-354168-omen8vvq 100 12 ( ( -LRB- cord-354168-omen8vvq 100 13 20 20 CD cord-354168-omen8vvq 100 14 mg mg NNP cord-354168-omen8vvq 100 15 p.o p.o NNP cord-354168-omen8vvq 100 16 . . NNP cord-354168-omen8vvq 100 17 daily daily RB cord-354168-omen8vvq 100 18 once once RB cord-354168-omen8vvq 100 19 weekly weekly RB cord-354168-omen8vvq 100 20 ) ) -RRB- cord-354168-omen8vvq 100 21 . . . cord-354168-omen8vvq 101 1 We -PRON- PRP cord-354168-omen8vvq 101 2 want want VBP cord-354168-omen8vvq 101 3 to to TO cord-354168-omen8vvq 101 4 stress stress VB cord-354168-omen8vvq 101 5 the the DT cord-354168-omen8vvq 101 6 point point NN cord-354168-omen8vvq 101 7 that that IN cord-354168-omen8vvq 101 8 bortezomib bortezomib NNP cord-354168-omen8vvq 101 9 should should MD cord-354168-omen8vvq 101 10 be be VB cord-354168-omen8vvq 101 11 given give VBN cord-354168-omen8vvq 101 12 subcutaneously subcutaneously RB cord-354168-omen8vvq 101 13 once once RB cord-354168-omen8vvq 101 14 a a DT cord-354168-omen8vvq 101 15 week week NN cord-354168-omen8vvq 101 16 , , , cord-354168-omen8vvq 101 17 rather rather RB cord-354168-omen8vvq 101 18 than than IN cord-354168-omen8vvq 101 19 intravenously intravenously RB cord-354168-omen8vvq 101 20 or or CC cord-354168-omen8vvq 101 21 twice twice RB cord-354168-omen8vvq 101 22 weekly weekly JJ cord-354168-omen8vvq 101 23 . . . cord-354168-omen8vvq 102 1 In in IN cord-354168-omen8vvq 102 2 some some DT cord-354168-omen8vvq 102 3 countries country NNS cord-354168-omen8vvq 102 4 , , , cord-354168-omen8vvq 102 5 cyclophosphamide cyclophosphamide RB cord-354168-omen8vvq 102 6 , , , cord-354168-omen8vvq 102 7 bortezomib bortezomib NNP cord-354168-omen8vvq 102 8 , , , cord-354168-omen8vvq 102 9 and and CC cord-354168-omen8vvq 102 10 dexamethasone dexamethasone NN cord-354168-omen8vvq 102 11 ( ( -LRB- cord-354168-omen8vvq 102 12 CyBorD CyBorD NNP cord-354168-omen8vvq 102 13 ) ) -RRB- cord-354168-omen8vvq 102 14 is be VBZ cord-354168-omen8vvq 102 15 the the DT cord-354168-omen8vvq 102 16 only only JJ cord-354168-omen8vvq 102 17 approved approve VBN cord-354168-omen8vvq 102 18 combination combination NN cord-354168-omen8vvq 102 19 for for IN cord-354168-omen8vvq 102 20 initial initial JJ cord-354168-omen8vvq 102 21 therapy therapy NN cord-354168-omen8vvq 102 22 . . . cord-354168-omen8vvq 103 1 We -PRON- PRP cord-354168-omen8vvq 103 2 again again RB cord-354168-omen8vvq 103 3 would would MD cord-354168-omen8vvq 103 4 recommend recommend VB cord-354168-omen8vvq 103 5 bortezomib bortezomib NNP cord-354168-omen8vvq 103 6 to to TO cord-354168-omen8vvq 103 7 be be VB cord-354168-omen8vvq 103 8 given give VBN cord-354168-omen8vvq 103 9 subcutaneously subcutaneously RB cord-354168-omen8vvq 103 10 once once RB cord-354168-omen8vvq 103 11 a a DT cord-354168-omen8vvq 103 12 week week NN cord-354168-omen8vvq 103 13 and and CC cord-354168-omen8vvq 103 14 the the DT cord-354168-omen8vvq 103 15 dose dose NN cord-354168-omen8vvq 103 16 of of IN cord-354168-omen8vvq 103 17 dexamethasone dexamethasone NN cord-354168-omen8vvq 103 18 reduced reduce VBN cord-354168-omen8vvq 103 19 to to IN cord-354168-omen8vvq 103 20 20 20 CD cord-354168-omen8vvq 103 21 mg mg NN cord-354168-omen8vvq 103 22 . . . cord-354168-omen8vvq 104 1 For for IN cord-354168-omen8vvq 104 2 High high JJ cord-354168-omen8vvq 104 3 - - HYPH cord-354168-omen8vvq 104 4 Risk risk NN cord-354168-omen8vvq 104 5 Patients patient NNS cord-354168-omen8vvq 104 6 Patients patient NNS cord-354168-omen8vvq 104 7 with with IN cord-354168-omen8vvq 104 8 high high JJ cord-354168-omen8vvq 104 9 - - HYPH cord-354168-omen8vvq 104 10 risk risk NN cord-354168-omen8vvq 104 11 features feature NNS cord-354168-omen8vvq 104 12 have have VBP cord-354168-omen8vvq 104 13 a a DT cord-354168-omen8vvq 104 14 different different JJ cord-354168-omen8vvq 104 15 biology biology NN cord-354168-omen8vvq 104 16 and and CC cord-354168-omen8vvq 104 17 the the DT cord-354168-omen8vvq 104 18 management management NN cord-354168-omen8vvq 104 19 of of IN cord-354168-omen8vvq 104 20 these these DT cord-354168-omen8vvq 104 21 patients patient NNS cord-354168-omen8vvq 104 22 can can MD cord-354168-omen8vvq 104 23 be be VB cord-354168-omen8vvq 104 24 very very RB cord-354168-omen8vvq 104 25 challenging challenging JJ cord-354168-omen8vvq 104 26 . . . cord-354168-omen8vvq 105 1 We -PRON- PRP cord-354168-omen8vvq 105 2 believe believe VBP cord-354168-omen8vvq 105 3 these these DT cord-354168-omen8vvq 105 4 patients patient NNS cord-354168-omen8vvq 105 5 have have VBP cord-354168-omen8vvq 105 6 a a DT cord-354168-omen8vvq 105 7 greater great JJR cord-354168-omen8vvq 105 8 risk risk NN cord-354168-omen8vvq 105 9 of of IN cord-354168-omen8vvq 105 10 morbidity morbidity NN cord-354168-omen8vvq 105 11 from from IN cord-354168-omen8vvq 105 12 myeloma myeloma NN cord-354168-omen8vvq 105 13 than than IN cord-354168-omen8vvq 105 14 COVID-19 covid-19 JJ cord-354168-omen8vvq 105 15 infection infection NN cord-354168-omen8vvq 105 16 justifying justify VBG cord-354168-omen8vvq 105 17 weekly weekly JJ cord-354168-omen8vvq 105 18 clinic clinic NN cord-354168-omen8vvq 105 19 visits visit NNS cord-354168-omen8vvq 105 20 for for IN cord-354168-omen8vvq 105 21 therapy therapy NN cord-354168-omen8vvq 105 22 , , , cord-354168-omen8vvq 105 23 while while IN cord-354168-omen8vvq 105 24 in in IN cord-354168-omen8vvq 105 25 standard standard JJ cord-354168-omen8vvq 105 26 - - HYPH cord-354168-omen8vvq 105 27 risk risk NN cord-354168-omen8vvq 105 28 patients patient NNS cord-354168-omen8vvq 105 29 an an DT cord-354168-omen8vvq 105 30 all all DT cord-354168-omen8vvq 105 31 oral oral JJ cord-354168-omen8vvq 105 32 regimen regimen NN cord-354168-omen8vvq 105 33 allows allow VBZ cord-354168-omen8vvq 105 34 for for IN cord-354168-omen8vvq 105 35 therapy therapy NN cord-354168-omen8vvq 105 36 visits visit NNS cord-354168-omen8vvq 105 37 every every DT cord-354168-omen8vvq 105 38 4 4 CD cord-354168-omen8vvq 105 39 weeks week NNS cord-354168-omen8vvq 105 40 . . . cord-354168-omen8vvq 106 1 For for IN cord-354168-omen8vvq 106 2 high high JJ cord-354168-omen8vvq 106 3 - - HYPH cord-354168-omen8vvq 106 4 risk risk NN cord-354168-omen8vvq 106 5 patients patient NNS cord-354168-omen8vvq 106 6 , , , cord-354168-omen8vvq 106 7 we -PRON- PRP cord-354168-omen8vvq 106 8 would would MD cord-354168-omen8vvq 106 9 recommend recommend VB cord-354168-omen8vvq 106 10 carfilzomib carfilzomib NNP cord-354168-omen8vvq 106 11 , , , cord-354168-omen8vvq 106 12 lenalidomide lenalidomide NN cord-354168-omen8vvq 106 13 , , , cord-354168-omen8vvq 106 14 and and CC cord-354168-omen8vvq 106 15 dexamethasone dexamethasone NN cord-354168-omen8vvq 106 16 ( ( -LRB- cord-354168-omen8vvq 106 17 KRd KRd NNS cord-354168-omen8vvq 106 18 ) ) -RRB- cord-354168-omen8vvq 106 19 given give VBN cord-354168-omen8vvq 106 20 over over IN cord-354168-omen8vvq 106 21 28 28 CD cord-354168-omen8vvq 106 22 days day NNS cord-354168-omen8vvq 106 23 for for IN cord-354168-omen8vvq 106 24 each each DT cord-354168-omen8vvq 106 25 cycle cycle NN cord-354168-omen8vvq 106 26 . . . cord-354168-omen8vvq 107 1 We -PRON- PRP cord-354168-omen8vvq 107 2 do do VBP cord-354168-omen8vvq 107 3 not not RB cord-354168-omen8vvq 107 4 believe believe VB cord-354168-omen8vvq 107 5 there there EX cord-354168-omen8vvq 107 6 is be VBZ cord-354168-omen8vvq 107 7 a a DT cord-354168-omen8vvq 107 8 high high JJ cord-354168-omen8vvq 107 9 risk risk NN cord-354168-omen8vvq 107 10 for for IN cord-354168-omen8vvq 107 11 tumor tumor NN cord-354168-omen8vvq 107 12 lysis lysis NN cord-354168-omen8vvq 107 13 syndrome syndrome NN cord-354168-omen8vvq 107 14 with with IN cord-354168-omen8vvq 107 15 MM MM NNP cord-354168-omen8vvq 108 1 and and CC cord-354168-omen8vvq 108 2 we -PRON- PRP cord-354168-omen8vvq 108 3 would would MD cord-354168-omen8vvq 108 4 recommend recommend VB cord-354168-omen8vvq 108 5 starting start VBG cord-354168-omen8vvq 108 6 therapy therapy NN cord-354168-omen8vvq 108 7 for for IN cord-354168-omen8vvq 108 8 the the DT cord-354168-omen8vvq 108 9 first first JJ cord-354168-omen8vvq 108 10 cycle cycle NN cord-354168-omen8vvq 108 11 with with IN cord-354168-omen8vvq 108 12 once once RB cord-354168-omen8vvq 108 13 - - HYPH cord-354168-omen8vvq 108 14 weekly weekly NN cord-354168-omen8vvq 108 15 dosing dosing NN cord-354168-omen8vvq 108 16 , , , cord-354168-omen8vvq 108 17 rather rather RB cord-354168-omen8vvq 108 18 than than IN cord-354168-omen8vvq 108 19 doing do VBG cord-354168-omen8vvq 108 20 day day NN cord-354168-omen8vvq 108 21 1 1 CD cord-354168-omen8vvq 108 22 and and CC cord-354168-omen8vvq 108 23 day day NN cord-354168-omen8vvq 108 24 2 2 CD cord-354168-omen8vvq 108 25 infusions infusion NNS cord-354168-omen8vvq 108 26 . . . cord-354168-omen8vvq 109 1 If if IN cord-354168-omen8vvq 109 2 the the DT cord-354168-omen8vvq 109 3 patient patient NN cord-354168-omen8vvq 109 4 has have VBZ cord-354168-omen8vvq 109 5 good good JJ cord-354168-omen8vvq 109 6 bone bone NN cord-354168-omen8vvq 109 7 marrow marrow NN cord-354168-omen8vvq 109 8 reserve reserve NN cord-354168-omen8vvq 109 9 , , , cord-354168-omen8vvq 109 10 we -PRON- PRP cord-354168-omen8vvq 109 11 would would MD cord-354168-omen8vvq 109 12 recommend recommend VB cord-354168-omen8vvq 109 13 carfilzomib carfilzomib NNP cord-354168-omen8vvq 109 14 at at IN cord-354168-omen8vvq 109 15 70 70 CD cord-354168-omen8vvq 109 16 mg/ mg/ NN cord-354168-omen8vvq 109 17 For for IN cord-354168-omen8vvq 109 18 Pneumocystis Pneumocystis NNP cord-354168-omen8vvq 109 19 jirovecii jirovecii NNP cord-354168-omen8vvq 109 20 prophylaxis prophylaxis NN cord-354168-omen8vvq 109 21 , , , cord-354168-omen8vvq 109 22 we -PRON- PRP cord-354168-omen8vvq 109 23 would would MD cord-354168-omen8vvq 109 24 recommend recommend VB cord-354168-omen8vvq 109 25 using use VBG cord-354168-omen8vvq 109 26 single single JJ cord-354168-omen8vvq 109 27 - - HYPH cord-354168-omen8vvq 109 28 strength strength NN cord-354168-omen8vvq 109 29 trimethoprim trimethoprim NNP cord-354168-omen8vvq 109 30 - - HYPH cord-354168-omen8vvq 109 31 sulfamethoxazole sulfamethoxazole NNP cord-354168-omen8vvq 109 32 given give VBN cord-354168-omen8vvq 109 33 daily daily JJ cord-354168-omen8vvq 109 34 or or CC cord-354168-omen8vvq 109 35 double double JJ cord-354168-omen8vvq 109 36 strength strength NN cord-354168-omen8vvq 109 37 given give VBN cord-354168-omen8vvq 109 38 on on IN cord-354168-omen8vvq 109 39 Monday Monday NNP cord-354168-omen8vvq 109 40 , , , cord-354168-omen8vvq 109 41 Wednesday Wednesday NNP cord-354168-omen8vvq 109 42 , , , cord-354168-omen8vvq 109 43 and and CC cord-354168-omen8vvq 109 44 Friday Friday NNP cord-354168-omen8vvq 109 45 . . . cord-354168-omen8vvq 110 1 If if IN cord-354168-omen8vvq 110 2 the the DT cord-354168-omen8vvq 110 3 patient patient NN cord-354168-omen8vvq 110 4 can can MD cord-354168-omen8vvq 110 5 not not RB cord-354168-omen8vvq 110 6 safely safely RB cord-354168-omen8vvq 110 7 receive receive VB cord-354168-omen8vvq 110 8 sulfa sulfa NN cord-354168-omen8vvq 110 9 , , , cord-354168-omen8vvq 110 10 we -PRON- PRP cord-354168-omen8vvq 110 11 would would MD cord-354168-omen8vvq 110 12 recommend recommend VB cord-354168-omen8vvq 110 13 using use VBG cord-354168-omen8vvq 110 14 prophylaxis prophylaxis NN cord-354168-omen8vvq 110 15 other other JJ cord-354168-omen8vvq 110 16 than than IN cord-354168-omen8vvq 110 17 pentamidine pentamidine NNP cord-354168-omen8vvq 110 18 , , , cord-354168-omen8vvq 110 19 as as IN cord-354168-omen8vvq 110 20 its -PRON- PRP$ cord-354168-omen8vvq 110 21 administration administration NN cord-354168-omen8vvq 110 22 requires require VBZ cord-354168-omen8vvq 110 23 a a DT cord-354168-omen8vvq 110 24 clinic clinic NN cord-354168-omen8vvq 110 25 visit visit NN cord-354168-omen8vvq 110 26 and and CC cord-354168-omen8vvq 110 27 the the DT cord-354168-omen8vvq 110 28 fact fact NN cord-354168-omen8vvq 110 29 that that IN cord-354168-omen8vvq 110 30 it -PRON- PRP cord-354168-omen8vvq 110 31 is be VBZ cord-354168-omen8vvq 110 32 an an DT cord-354168-omen8vvq 110 33 aerosolized aerosolize VBN cord-354168-omen8vvq 110 34 therapy therapy NN cord-354168-omen8vvq 110 35 could could MD cord-354168-omen8vvq 110 36 be be VB cord-354168-omen8vvq 110 37 a a DT cord-354168-omen8vvq 110 38 concern concern NN cord-354168-omen8vvq 110 39 with with IN cord-354168-omen8vvq 110 40 the the DT cord-354168-omen8vvq 110 41 current current JJ cord-354168-omen8vvq 110 42 COVID-19 COVID-19 NNP cord-354168-omen8vvq 110 43 pandemic pandemic NN cord-354168-omen8vvq 110 44 . . . cord-354168-omen8vvq 111 1 For for IN cord-354168-omen8vvq 111 2 bone bone NN cord-354168-omen8vvq 111 3 disease disease NN cord-354168-omen8vvq 111 4 prophylaxis prophylaxis NN cord-354168-omen8vvq 111 5 , , , cord-354168-omen8vvq 111 6 we -PRON- PRP cord-354168-omen8vvq 111 7 believe believe VBP cord-354168-omen8vvq 111 8 that that IN cord-354168-omen8vvq 111 9 it -PRON- PRP cord-354168-omen8vvq 111 10 can can MD cord-354168-omen8vvq 111 11 be be VB cord-354168-omen8vvq 111 12 delayed delay VBN cord-354168-omen8vvq 111 13 , , , cord-354168-omen8vvq 111 14 especially especially RB cord-354168-omen8vvq 111 15 in in IN cord-354168-omen8vvq 111 16 patients patient NNS cord-354168-omen8vvq 111 17 without without IN cord-354168-omen8vvq 111 18 active active JJ cord-354168-omen8vvq 111 19 bone bone NN cord-354168-omen8vvq 111 20 disease disease NN cord-354168-omen8vvq 111 21 . . . cord-354168-omen8vvq 112 1 If if IN cord-354168-omen8vvq 112 2 a a DT cord-354168-omen8vvq 112 3 patient patient NN cord-354168-omen8vvq 112 4 has have VBZ cord-354168-omen8vvq 112 5 diffuse diffuse JJ cord-354168-omen8vvq 112 6 bone bone NN cord-354168-omen8vvq 112 7 disease disease NN cord-354168-omen8vvq 112 8 or or CC cord-354168-omen8vvq 112 9 has have VBZ cord-354168-omen8vvq 112 10 hypercalcemia hypercalcemia NN cord-354168-omen8vvq 112 11 , , , cord-354168-omen8vvq 112 12 then then RB cord-354168-omen8vvq 112 13 we -PRON- PRP cord-354168-omen8vvq 112 14 would would MD cord-354168-omen8vvq 112 15 recommend recommend VB cord-354168-omen8vvq 112 16 using use VBG cord-354168-omen8vvq 112 17 zoledronic zoledronic NNP cord-354168-omen8vvq 112 18 acid acid NN cord-354168-omen8vvq 112 19 . . . cord-354168-omen8vvq 113 1 For for IN cord-354168-omen8vvq 113 2 bone bone NN cord-354168-omen8vvq 113 3 prophylaxis prophylaxis NN cord-354168-omen8vvq 113 4 , , , cord-354168-omen8vvq 113 5 this this DT cord-354168-omen8vvq 113 6 can can MD cord-354168-omen8vvq 113 7 be be VB cord-354168-omen8vvq 113 8 given give VBN cord-354168-omen8vvq 113 9 every every DT cord-354168-omen8vvq 113 10 3 3 CD cord-354168-omen8vvq 113 11 months month NNS cord-354168-omen8vvq 113 12 , , , cord-354168-omen8vvq 113 13 rather rather RB cord-354168-omen8vvq 113 14 than than IN cord-354168-omen8vvq 113 15 monthly monthly JJ cord-354168-omen8vvq 113 16 . . . cord-354168-omen8vvq 114 1 Patients patient NNS cord-354168-omen8vvq 114 2 should should MD cord-354168-omen8vvq 114 3 be be VB cord-354168-omen8vvq 114 4 advised advise VBN cord-354168-omen8vvq 114 5 to to TO cord-354168-omen8vvq 114 6 take take VB cord-354168-omen8vvq 114 7 calcium calcium NN cord-354168-omen8vvq 114 8 and and CC cord-354168-omen8vvq 114 9 vitamin vitamin NN cord-354168-omen8vvq 114 10 D. D. NNP cord-354168-omen8vvq 115 1 We -PRON- PRP cord-354168-omen8vvq 115 2 do do VBP cord-354168-omen8vvq 115 3 not not RB cord-354168-omen8vvq 115 4 recommend recommend VB cord-354168-omen8vvq 115 5 using use VBG cord-354168-omen8vvq 115 6 growth growth NN cord-354168-omen8vvq 115 7 factors factor NNS cord-354168-omen8vvq 115 8 . . . cord-354168-omen8vvq 116 1 If if IN cord-354168-omen8vvq 116 2 a a DT cord-354168-omen8vvq 116 3 patient patient NN cord-354168-omen8vvq 116 4 requires require VBZ cord-354168-omen8vvq 116 5 it -PRON- PRP cord-354168-omen8vvq 116 6 , , , cord-354168-omen8vvq 116 7 we -PRON- PRP cord-354168-omen8vvq 116 8 would would MD cord-354168-omen8vvq 116 9 recommend recommend VB cord-354168-omen8vvq 116 10 using use VBG cord-354168-omen8vvq 116 11 pegfilgrastim pegfilgrastim NNP cord-354168-omen8vvq 116 12 , , , cord-354168-omen8vvq 116 13 if if IN cord-354168-omen8vvq 116 14 possible possible JJ cord-354168-omen8vvq 116 15 . . . cord-354168-omen8vvq 117 1 We -PRON- PRP cord-354168-omen8vvq 117 2 would would MD cord-354168-omen8vvq 117 3 recommend recommend VB cord-354168-omen8vvq 117 4 decreasing decrease VBG cord-354168-omen8vvq 117 5 the the DT cord-354168-omen8vvq 117 6 frequency frequency NN cord-354168-omen8vvq 117 7 of of IN cord-354168-omen8vvq 117 8 blood blood NN cord-354168-omen8vvq 117 9 work work NN cord-354168-omen8vvq 117 10 during during IN cord-354168-omen8vvq 117 11 each each DT cord-354168-omen8vvq 117 12 cycle cycle NN cord-354168-omen8vvq 117 13 as as RB cord-354168-omen8vvq 117 14 much much RB cord-354168-omen8vvq 117 15 as as IN cord-354168-omen8vvq 117 16 possible possible JJ cord-354168-omen8vvq 117 17 . . . cord-354168-omen8vvq 118 1 If if IN cord-354168-omen8vvq 118 2 the the DT cord-354168-omen8vvq 118 3 patient patient NN cord-354168-omen8vvq 118 4 has have VBZ cord-354168-omen8vvq 118 5 good good JJ cord-354168-omen8vvq 118 6 bone bone NN cord-354168-omen8vvq 118 7 marrow marrow NN cord-354168-omen8vvq 118 8 reserve reserve NN cord-354168-omen8vvq 118 9 , , , cord-354168-omen8vvq 118 10 blood blood NN cord-354168-omen8vvq 118 11 work work NN cord-354168-omen8vvq 118 12 can can MD cord-354168-omen8vvq 118 13 be be VB cord-354168-omen8vvq 118 14 done do VBN cord-354168-omen8vvq 118 15 after after IN cord-354168-omen8vvq 118 16 finishing finish VBG cord-354168-omen8vvq 118 17 the the DT cord-354168-omen8vvq 118 18 cycle cycle NN cord-354168-omen8vvq 118 19 ( ( -LRB- cord-354168-omen8vvq 118 20 before before IN cord-354168-omen8vvq 118 21 starting start VBG cord-354168-omen8vvq 118 22 the the DT cord-354168-omen8vvq 118 23 next next JJ cord-354168-omen8vvq 118 24 cycle cycle NN cord-354168-omen8vvq 118 25 ) ) -RRB- cord-354168-omen8vvq 118 26 , , , cord-354168-omen8vvq 118 27 rather rather RB cord-354168-omen8vvq 118 28 than than IN cord-354168-omen8vvq 118 29 checking check VBG cord-354168-omen8vvq 118 30 counts count NNS cord-354168-omen8vvq 118 31 routinely routinely RB cord-354168-omen8vvq 118 32 every every DT cord-354168-omen8vvq 118 33 week week NN cord-354168-omen8vvq 118 34 during during IN cord-354168-omen8vvq 118 35 the the DT cord-354168-omen8vvq 118 36 first first JJ cord-354168-omen8vvq 118 37 cycle cycle NN cord-354168-omen8vvq 118 38 . . . cord-354168-omen8vvq 119 1 We -PRON- PRP cord-354168-omen8vvq 119 2 also also RB cord-354168-omen8vvq 119 3 recommend recommend VBP cord-354168-omen8vvq 119 4 followup followup JJ cord-354168-omen8vvq 119 5 using use VBG cord-354168-omen8vvq 119 6 telehealth telehealth NN cord-354168-omen8vvq 119 7 technologies technology NNS cord-354168-omen8vvq 119 8 ( ( -LRB- cord-354168-omen8vvq 119 9 telephone telephone NN cord-354168-omen8vvq 119 10 calls call NNS cord-354168-omen8vvq 119 11 , , , cord-354168-omen8vvq 119 12 video video NN cord-354168-omen8vvq 119 13 , , , cord-354168-omen8vvq 119 14 etc etc FW cord-354168-omen8vvq 119 15 . . . cord-354168-omen8vvq 119 16 ) ) -RRB- cord-354168-omen8vvq 119 17 . . . cord-354168-omen8vvq 120 1 Drug drug NN cord-354168-omen8vvq 120 2 companies company NNS cord-354168-omen8vvq 120 3 have have VBP cord-354168-omen8vvq 120 4 extended extend VBN cord-354168-omen8vvq 120 5 the the DT cord-354168-omen8vvq 120 6 supply supply NN cord-354168-omen8vvq 120 7 of of IN cord-354168-omen8vvq 120 8 lenalidomide lenalidomide NN cord-354168-omen8vvq 120 9 and and CC cord-354168-omen8vvq 120 10 pomalidomide pomalidomide NN cord-354168-omen8vvq 120 11 to to IN cord-354168-omen8vvq 120 12 8 8 CD cord-354168-omen8vvq 120 13 weeks week NNS cord-354168-omen8vvq 120 14 with with IN cord-354168-omen8vvq 120 15 drugs drug NNS cord-354168-omen8vvq 120 16 being be VBG cord-354168-omen8vvq 120 17 shipped ship VBN cord-354168-omen8vvq 120 18 home home RB cord-354168-omen8vvq 120 19 , , , cord-354168-omen8vvq 120 20 rather rather RB cord-354168-omen8vvq 120 21 than than IN cord-354168-omen8vvq 120 22 requiring require VBG cord-354168-omen8vvq 120 23 a a DT cord-354168-omen8vvq 120 24 visit visit NN cord-354168-omen8vvq 120 25 to to IN cord-354168-omen8vvq 120 26 a a DT cord-354168-omen8vvq 120 27 specialized specialized JJ cord-354168-omen8vvq 120 28 pharmacy pharmacy NN cord-354168-omen8vvq 120 29 . . . cord-354168-omen8vvq 121 1 This this DT cord-354168-omen8vvq 121 2 will will MD cord-354168-omen8vvq 121 3 help help VB cord-354168-omen8vvq 121 4 reduce reduce VB cord-354168-omen8vvq 121 5 potential potential JJ cord-354168-omen8vvq 121 6 exposure exposure NN cord-354168-omen8vvq 121 7 to to IN cord-354168-omen8vvq 121 8 COVID-19 COVID-19 NNP cord-354168-omen8vvq 121 9 . . . cord-354168-omen8vvq 122 1 Autologous autologous JJ cord-354168-omen8vvq 122 2 stem stem NN cord-354168-omen8vvq 122 3 cell cell NN cord-354168-omen8vvq 122 4 transplant transplant NN cord-354168-omen8vvq 122 5 ( ( -LRB- cord-354168-omen8vvq 122 6 ASCT ASCT NNP cord-354168-omen8vvq 122 7 ) ) -RRB- cord-354168-omen8vvq 122 8 clearly clearly RB cord-354168-omen8vvq 122 9 improves improve VBZ cord-354168-omen8vvq 122 10 outcomes outcome NNS cord-354168-omen8vvq 122 11 in in IN cord-354168-omen8vvq 122 12 newly newly RB cord-354168-omen8vvq 122 13 diagnosed diagnose VBN cord-354168-omen8vvq 122 14 MM MM NNP cord-354168-omen8vvq 122 15 patients patient NNS cord-354168-omen8vvq 122 16 . . . cord-354168-omen8vvq 123 1 However however RB cord-354168-omen8vvq 123 2 , , , cord-354168-omen8vvq 123 3 during during IN cord-354168-omen8vvq 123 4 this this DT cord-354168-omen8vvq 123 5 challenging challenging JJ cord-354168-omen8vvq 123 6 time time NN cord-354168-omen8vvq 123 7 , , , cord-354168-omen8vvq 123 8 each each DT cord-354168-omen8vvq 123 9 patient patient NN cord-354168-omen8vvq 123 10 should should MD cord-354168-omen8vvq 123 11 be be VB cord-354168-omen8vvq 123 12 evaluated evaluate VBN cord-354168-omen8vvq 123 13 individually individually RB cord-354168-omen8vvq 123 14 . . . cord-354168-omen8vvq 124 1 Multiple multiple JJ cord-354168-omen8vvq 124 2 trials trial NNS cord-354168-omen8vvq 124 3 have have VBP cord-354168-omen8vvq 124 4 evaluated evaluate VBN cord-354168-omen8vvq 124 5 upfront upfront NN cord-354168-omen8vvq 124 6 versus versus IN cord-354168-omen8vvq 124 7 delayed delay VBN cord-354168-omen8vvq 124 8 ASCT ASCT NNP cord-354168-omen8vvq 124 9 and and CC cord-354168-omen8vvq 124 10 overall overall JJ cord-354168-omen8vvq 124 11 , , , cord-354168-omen8vvq 124 12 upfront upfront JJ cord-354168-omen8vvq 124 13 ASCT ASCT NNP cord-354168-omen8vvq 124 14 improves improve VBZ cord-354168-omen8vvq 124 15 PFS PFS NNP cord-354168-omen8vvq 124 16 , , , cord-354168-omen8vvq 124 17 but but CC cord-354168-omen8vvq 124 18 not not RB cord-354168-omen8vvq 124 19 OS OS NNP cord-354168-omen8vvq 124 20 [ [ -LRB- cord-354168-omen8vvq 124 21 27 27 CD cord-354168-omen8vvq 124 22 ] ] -RRB- cord-354168-omen8vvq 124 23 [ [ -LRB- cord-354168-omen8vvq 124 24 28 28 CD cord-354168-omen8vvq 124 25 ] ] -RRB- cord-354168-omen8vvq 124 26 [ [ -LRB- cord-354168-omen8vvq 124 27 29 29 CD cord-354168-omen8vvq 124 28 ] ] -RRB- cord-354168-omen8vvq 124 29 [ [ -LRB- cord-354168-omen8vvq 124 30 30 30 CD cord-354168-omen8vvq 124 31 ] ] -RRB- cord-354168-omen8vvq 124 32 [ [ -LRB- cord-354168-omen8vvq 124 33 31 31 CD cord-354168-omen8vvq 124 34 ] ] -RRB- cord-354168-omen8vvq 124 35 . . . cord-354168-omen8vvq 125 1 The the DT cord-354168-omen8vvq 125 2 two two CD cord-354168-omen8vvq 125 3 main main JJ cord-354168-omen8vvq 125 4 concerns concern NNS cord-354168-omen8vvq 125 5 with with IN cord-354168-omen8vvq 125 6 the the DT cord-354168-omen8vvq 125 7 current current JJ cord-354168-omen8vvq 125 8 COVID-19 COVID-19 NNP cord-354168-omen8vvq 125 9 pandemic pandemic NN cord-354168-omen8vvq 125 10 is be VBZ cord-354168-omen8vvq 125 11 that that IN cord-354168-omen8vvq 125 12 patients patient NNS cord-354168-omen8vvq 125 13 need need VBP cord-354168-omen8vvq 125 14 their -PRON- PRP$ cord-354168-omen8vvq 125 15 stem stem NN cord-354168-omen8vvq 125 16 cells cell NNS cord-354168-omen8vvq 125 17 collected collect VBN cord-354168-omen8vvq 125 18 and and CC cord-354168-omen8vvq 125 19 some some DT cord-354168-omen8vvq 125 20 patients patient NNS cord-354168-omen8vvq 125 21 require require VBP cord-354168-omen8vvq 125 22 more more JJR cord-354168-omen8vvq 125 23 than than IN cord-354168-omen8vvq 125 24 one one CD cord-354168-omen8vvq 125 25 apheresis apheresis NN cord-354168-omen8vvq 125 26 . . . cord-354168-omen8vvq 126 1 With with IN cord-354168-omen8vvq 126 2 conditioning conditioning NN cord-354168-omen8vvq 126 3 comes come VBZ cord-354168-omen8vvq 126 4 the the DT cord-354168-omen8vvq 126 5 increased increase VBN cord-354168-omen8vvq 126 6 risk risk NN cord-354168-omen8vvq 126 7 of of IN cord-354168-omen8vvq 126 8 infection infection NN cord-354168-omen8vvq 126 9 related relate VBN cord-354168-omen8vvq 126 10 to to IN cord-354168-omen8vvq 126 11 the the DT cord-354168-omen8vvq 126 12 7 7 CD cord-354168-omen8vvq 126 13 - - SYM cord-354168-omen8vvq 126 14 9 9 CD cord-354168-omen8vvq 126 15 days day NNS cord-354168-omen8vvq 126 16 of of IN cord-354168-omen8vvq 126 17 severe severe JJ cord-354168-omen8vvq 126 18 neutropenia neutropenia NN cord-354168-omen8vvq 126 19 . . . cord-354168-omen8vvq 127 1 For for IN cord-354168-omen8vvq 127 2 standard standard JJ cord-354168-omen8vvq 127 3 - - HYPH cord-354168-omen8vvq 127 4 risk risk NN cord-354168-omen8vvq 127 5 patients patient NNS cord-354168-omen8vvq 127 6 who who WP cord-354168-omen8vvq 127 7 are be VBP cord-354168-omen8vvq 127 8 responding respond VBG cord-354168-omen8vvq 127 9 well well RB cord-354168-omen8vvq 127 10 to to IN cord-354168-omen8vvq 127 11 therapy therapy NN cord-354168-omen8vvq 127 12 , , , cord-354168-omen8vvq 127 13 we -PRON- PRP cord-354168-omen8vvq 127 14 would would MD cord-354168-omen8vvq 127 15 recommend recommend VB cord-354168-omen8vvq 127 16 delaying delay VBG cord-354168-omen8vvq 127 17 ASCT ASCT NNP cord-354168-omen8vvq 127 18 until until IN cord-354168-omen8vvq 127 19 the the DT cord-354168-omen8vvq 127 20 current current JJ cord-354168-omen8vvq 127 21 situation situation NN cord-354168-omen8vvq 127 22 with with IN cord-354168-omen8vvq 127 23 COVID-19 COVID-19 NNP cord-354168-omen8vvq 127 24 improves improve NNS cord-354168-omen8vvq 127 25 . . . cord-354168-omen8vvq 128 1 Continued continued JJ cord-354168-omen8vvq 128 2 induction induction NN cord-354168-omen8vvq 128 3 therapy therapy NN cord-354168-omen8vvq 128 4 can can MD cord-354168-omen8vvq 128 5 safely safely RB cord-354168-omen8vvq 128 6 be be VB cord-354168-omen8vvq 128 7 used use VBN cord-354168-omen8vvq 128 8 as as IN cord-354168-omen8vvq 128 9 a a DT cord-354168-omen8vvq 128 10 bridge bridge NN cord-354168-omen8vvq 128 11 until until IN cord-354168-omen8vvq 128 12 the the DT cord-354168-omen8vvq 128 13 epidemic epidemic NN cord-354168-omen8vvq 128 14 subsides subside VBZ cord-354168-omen8vvq 128 15 [ [ -LRB- cord-354168-omen8vvq 128 16 32 32 CD cord-354168-omen8vvq 128 17 ] ] -RRB- cord-354168-omen8vvq 128 18 . . . cord-354168-omen8vvq 129 1 For for IN cord-354168-omen8vvq 129 2 high high JJ cord-354168-omen8vvq 129 3 - - HYPH cord-354168-omen8vvq 129 4 risk risk NN cord-354168-omen8vvq 129 5 patients patient NNS cord-354168-omen8vvq 129 6 , , , cord-354168-omen8vvq 129 7 if if IN cord-354168-omen8vvq 129 8 they -PRON- PRP cord-354168-omen8vvq 129 9 are be VBP cord-354168-omen8vvq 129 10 responding respond VBG cord-354168-omen8vvq 129 11 ( ( -LRB- cord-354168-omen8vvq 129 12 at at IN cord-354168-omen8vvq 129 13 least least JJS cord-354168-omen8vvq 129 14 with with IN cord-354168-omen8vvq 129 15 partial partial JJ cord-354168-omen8vvq 129 16 response response NN cord-354168-omen8vvq 129 17 ) ) -RRB- cord-354168-omen8vvq 129 18 ASCT ASCT NNP cord-354168-omen8vvq 129 19 can can MD cord-354168-omen8vvq 129 20 be be VB cord-354168-omen8vvq 129 21 delayed delay VBN cord-354168-omen8vvq 129 22 . . . cord-354168-omen8vvq 130 1 However however RB cord-354168-omen8vvq 130 2 , , , cord-354168-omen8vvq 130 3 patients patient NNS cord-354168-omen8vvq 130 4 who who WP cord-354168-omen8vvq 130 5 are be VBP cord-354168-omen8vvq 130 6 not not RB cord-354168-omen8vvq 130 7 responding respond VBG cord-354168-omen8vvq 130 8 or or CC cord-354168-omen8vvq 130 9 progressing progress VBG cord-354168-omen8vvq 130 10 quickly quickly RB cord-354168-omen8vvq 130 11 , , , cord-354168-omen8vvq 130 12 ASCT ASCT NNP cord-354168-omen8vvq 130 13 can can MD cord-354168-omen8vvq 130 14 be be VB cord-354168-omen8vvq 130 15 considered consider VBN cord-354168-omen8vvq 130 16 as as IN cord-354168-omen8vvq 130 17 salvage salvage NN cord-354168-omen8vvq 130 18 therapy therapy NN cord-354168-omen8vvq 130 19 . . . cord-354168-omen8vvq 131 1 Testing test VBG cord-354168-omen8vvq 131 2 for for IN cord-354168-omen8vvq 131 3 COV COV NNP cord-354168-omen8vvq 131 4 - - HYPH cord-354168-omen8vvq 131 5 ID-19 ID-19 NNP cord-354168-omen8vvq 131 6 should should MD cord-354168-omen8vvq 131 7 be be VB cord-354168-omen8vvq 131 8 done do VBN cord-354168-omen8vvq 131 9 before before IN cord-354168-omen8vvq 131 10 ASCT ASCT NNP cord-354168-omen8vvq 131 11 . . . cord-354168-omen8vvq 132 1 Balancing balance VBG cord-354168-omen8vvq 132 2 the the DT cord-354168-omen8vvq 132 3 risks risk NNS cord-354168-omen8vvq 132 4 of of IN cord-354168-omen8vvq 132 5 COVID-19 covid-19 JJ cord-354168-omen8vvq 132 6 infection infection NN cord-354168-omen8vvq 132 7 and and CC cord-354168-omen8vvq 132 8 MM mm NN cord-354168-omen8vvq 132 9 - - HYPH cord-354168-omen8vvq 132 10 related relate VBN cord-354168-omen8vvq 132 11 mortality mortality NN cord-354168-omen8vvq 132 12 is be VBZ cord-354168-omen8vvq 132 13 difficult difficult JJ cord-354168-omen8vvq 132 14 . . . cord-354168-omen8vvq 133 1 Consultation consultation NN cord-354168-omen8vvq 133 2 with with IN cord-354168-omen8vvq 133 3 a a DT cord-354168-omen8vvq 133 4 MM MM NNP cord-354168-omen8vvq 133 5 expert expert NN cord-354168-omen8vvq 133 6 is be VBZ cord-354168-omen8vvq 133 7 recommended recommend VBN cord-354168-omen8vvq 133 8 . . . cord-354168-omen8vvq 134 1 These these DT cord-354168-omen8vvq 134 2 are be VBP cord-354168-omen8vvq 134 3 the the DT cord-354168-omen8vvq 134 4 most most RBS cord-354168-omen8vvq 134 5 challenging challenging JJ cord-354168-omen8vvq 134 6 patients patient NNS cord-354168-omen8vvq 134 7 during during IN cord-354168-omen8vvq 134 8 the the DT cord-354168-omen8vvq 134 9 current current JJ cord-354168-omen8vvq 134 10 pandemic pandemic NN cord-354168-omen8vvq 134 11 . . . cord-354168-omen8vvq 135 1 The the DT cord-354168-omen8vvq 135 2 median median JJ cord-354168-omen8vvq 135 3 OS os NN cord-354168-omen8vvq 135 4 in in IN cord-354168-omen8vvq 135 5 these these DT cord-354168-omen8vvq 135 6 patients patient NNS cord-354168-omen8vvq 135 7 is be VBZ cord-354168-omen8vvq 135 8 less less JJR cord-354168-omen8vvq 135 9 than than IN cord-354168-omen8vvq 135 10 a a DT cord-354168-omen8vvq 135 11 year year NN cord-354168-omen8vvq 135 12 with with IN cord-354168-omen8vvq 135 13 current current JJ cord-354168-omen8vvq 135 14 treatment treatment NN cord-354168-omen8vvq 135 15 approaches approach NNS cord-354168-omen8vvq 135 16 [ [ -LRB- cord-354168-omen8vvq 135 17 33 33 CD cord-354168-omen8vvq 135 18 ] ] -RRB- cord-354168-omen8vvq 135 19 . . . cord-354168-omen8vvq 136 1 We -PRON- PRP cord-354168-omen8vvq 136 2 believe believe VBP cord-354168-omen8vvq 136 3 that that IN cord-354168-omen8vvq 136 4 induction induction NN cord-354168-omen8vvq 136 5 chemotherapy chemotherapy NN cord-354168-omen8vvq 136 6 followed follow VBN cord-354168-omen8vvq 136 7 by by IN cord-354168-omen8vvq 136 8 ASCT ASCT NNP cord-354168-omen8vvq 136 9 should should MD cord-354168-omen8vvq 136 10 be be VB cord-354168-omen8vvq 136 11 done do VBN cord-354168-omen8vvq 136 12 for for IN cord-354168-omen8vvq 136 13 these these DT cord-354168-omen8vvq 136 14 patients patient NNS cord-354168-omen8vvq 136 15 , , , cord-354168-omen8vvq 136 16 as as IN cord-354168-omen8vvq 136 17 the the DT cord-354168-omen8vvq 136 18 risk risk NN cord-354168-omen8vvq 136 19 of of IN cord-354168-omen8vvq 136 20 progressive progressive JJ cord-354168-omen8vvq 136 21 disease disease NN cord-354168-omen8vvq 136 22 is be VBZ cord-354168-omen8vvq 136 23 high high JJ cord-354168-omen8vvq 136 24 . . . cord-354168-omen8vvq 137 1 Testing test VBG cord-354168-omen8vvq 137 2 for for IN cord-354168-omen8vvq 137 3 COVID-19 COVID-19 NNP cord-354168-omen8vvq 137 4 should should MD cord-354168-omen8vvq 137 5 be be VB cord-354168-omen8vvq 137 6 done do VBN cord-354168-omen8vvq 137 7 before before IN cord-354168-omen8vvq 137 8 ASCT ASCT NNP cord-354168-omen8vvq 137 9 . . . cord-354168-omen8vvq 138 1 There there EX cord-354168-omen8vvq 138 2 are be VBP cord-354168-omen8vvq 138 3 no no DT cord-354168-omen8vvq 138 4 major major JJ cord-354168-omen8vvq 138 5 concerns concern NNS cord-354168-omen8vvq 138 6 for for IN cord-354168-omen8vvq 138 7 collection collection NN cord-354168-omen8vvq 138 8 , , , cord-354168-omen8vvq 138 9 as as IN cord-354168-omen8vvq 138 10 patients patient NNS cord-354168-omen8vvq 138 11 receiving receive VBG cord-354168-omen8vvq 138 12 IMiD imid NN cord-354168-omen8vvq 138 13 - - HYPH cord-354168-omen8vvq 138 14 based base VBN cord-354168-omen8vvq 138 15 therapy therapy NN cord-354168-omen8vvq 138 16 can can MD cord-354168-omen8vvq 138 17 successfully successfully RB cord-354168-omen8vvq 138 18 undergo undergo VB cord-354168-omen8vvq 138 19 stem stem NN cord-354168-omen8vvq 138 20 cell cell NN cord-354168-omen8vvq 138 21 collection collection NN cord-354168-omen8vvq 138 22 after after IN cord-354168-omen8vvq 138 23 6 6 CD cord-354168-omen8vvq 138 24 cycles cycle NNS cord-354168-omen8vvq 138 25 [ [ -LRB- cord-354168-omen8vvq 138 26 34 34 CD cord-354168-omen8vvq 138 27 ] ] -RRB- cord-354168-omen8vvq 138 28 using use VBG cord-354168-omen8vvq 138 29 granulocyte granulocyte NN cord-354168-omen8vvq 138 30 colony colony NN cord-354168-omen8vvq 138 31 - - HYPH cord-354168-omen8vvq 138 32 stimulating stimulate VBG cord-354168-omen8vvq 138 33 factor factor NN cord-354168-omen8vvq 138 34 ( ( -LRB- cord-354168-omen8vvq 138 35 G G NNP cord-354168-omen8vvq 138 36 - - HYPH cord-354168-omen8vvq 138 37 CSF CSF NNP cord-354168-omen8vvq 138 38 ) ) -RRB- cord-354168-omen8vvq 138 39 . . . cord-354168-omen8vvq 139 1 For for IN cord-354168-omen8vvq 139 2 patients patient NNS cord-354168-omen8vvq 139 3 who who WP cord-354168-omen8vvq 139 4 fail fail VBP cord-354168-omen8vvq 139 5 to to TO cord-354168-omen8vvq 139 6 collect collect VB cord-354168-omen8vvq 139 7 using use VBG cord-354168-omen8vvq 139 8 G G NNP cord-354168-omen8vvq 139 9 - - HYPH cord-354168-omen8vvq 139 10 CSF CSF NNP cord-354168-omen8vvq 139 11 , , , cord-354168-omen8vvq 139 12 plerixafor plerixafor NN cord-354168-omen8vvq 139 13 can can MD cord-354168-omen8vvq 139 14 be be VB cord-354168-omen8vvq 139 15 used use VBN cord-354168-omen8vvq 139 16 . . . cord-354168-omen8vvq 140 1 Delaying delay VBG cord-354168-omen8vvq 140 2 stem stem NN cord-354168-omen8vvq 140 3 cell cell NN cord-354168-omen8vvq 140 4 collection collection NN cord-354168-omen8vvq 140 5 is be VBZ cord-354168-omen8vvq 140 6 wise wise JJ cord-354168-omen8vvq 140 7 , , , cord-354168-omen8vvq 140 8 especially especially RB cord-354168-omen8vvq 140 9 in in IN cord-354168-omen8vvq 140 10 patients patient NNS cord-354168-omen8vvq 140 11 who who WP cord-354168-omen8vvq 140 12 had have VBD cord-354168-omen8vvq 140 13 a a DT cord-354168-omen8vvq 140 14 recent recent JJ cord-354168-omen8vvq 140 15 COVID-19 covid-19 CD cord-354168-omen8vvq 140 16 infection infection NN cord-354168-omen8vvq 140 17 . . . cord-354168-omen8vvq 141 1 Hyperimmunity Hyperimmunity NNP cord-354168-omen8vvq 141 2 with with IN cord-354168-omen8vvq 141 3 cytokine cytokine NN cord-354168-omen8vvq 141 4 storms storm NNS cord-354168-omen8vvq 141 5 and and CC cord-354168-omen8vvq 141 6 acute acute JJ cord-354168-omen8vvq 141 7 respiratory respiratory JJ cord-354168-omen8vvq 141 8 distress distress NN cord-354168-omen8vvq 141 9 syndrome syndrome NN cord-354168-omen8vvq 141 10 from from IN cord-354168-omen8vvq 141 11 the the DT cord-354168-omen8vvq 141 12 infection infection NN cord-354168-omen8vvq 141 13 has have VBZ cord-354168-omen8vvq 141 14 been be VBN cord-354168-omen8vvq 141 15 described describe VBN cord-354168-omen8vvq 141 16 [ [ -LRB- cord-354168-omen8vvq 141 17 35 35 CD cord-354168-omen8vvq 141 18 , , , cord-354168-omen8vvq 141 19 36 36 CD cord-354168-omen8vvq 141 20 ] ] -RRB- cord-354168-omen8vvq 141 21 . . . cord-354168-omen8vvq 142 1 In in IN cord-354168-omen8vvq 142 2 theory theory NN cord-354168-omen8vvq 142 3 G G NNP cord-354168-omen8vvq 142 4 - - HYPH cord-354168-omen8vvq 142 5 CSF CSF NNP cord-354168-omen8vvq 142 6 can can MD cord-354168-omen8vvq 142 7 reinitiate reinitiate VB cord-354168-omen8vvq 142 8 the the DT cord-354168-omen8vvq 142 9 immune immune JJ cord-354168-omen8vvq 142 10 stimulus stimulus NN cord-354168-omen8vvq 142 11 leading lead VBG cord-354168-omen8vvq 142 12 to to IN cord-354168-omen8vvq 142 13 complications complication NNS cord-354168-omen8vvq 142 14 . . . cord-354168-omen8vvq 143 1 Acta Acta NNP cord-354168-omen8vvq 143 2 Haematol Haematol NNP cord-354168-omen8vvq 143 3 DOI DOI NNP cord-354168-omen8vvq 143 4 : : : cord-354168-omen8vvq 143 5 10.1159/000507690 10.1159/000507690 CD cord-354168-omen8vvq 144 1 In in IN cord-354168-omen8vvq 144 2 general general JJ cord-354168-omen8vvq 144 3 , , , cord-354168-omen8vvq 144 4 we -PRON- PRP cord-354168-omen8vvq 144 5 would would MD cord-354168-omen8vvq 144 6 recommend recommend VB cord-354168-omen8vvq 144 7 continuing continue VBG cord-354168-omen8vvq 144 8 with with IN cord-354168-omen8vvq 144 9 treatment treatment NN cord-354168-omen8vvq 144 10 until until IN cord-354168-omen8vvq 144 11 the the DT cord-354168-omen8vvq 144 12 current current JJ cord-354168-omen8vvq 144 13 epidemic epidemic NN cord-354168-omen8vvq 144 14 with with IN cord-354168-omen8vvq 144 15 COVID-19 COVID-19 NNP cord-354168-omen8vvq 144 16 improves improve NNS cord-354168-omen8vvq 144 17 and and CC cord-354168-omen8vvq 144 18 ASCT ASCT NNP cord-354168-omen8vvq 144 19 is be VBZ cord-354168-omen8vvq 144 20 safer safe JJR cord-354168-omen8vvq 144 21 . . . cord-354168-omen8vvq 145 1 Patients patient NNS cord-354168-omen8vvq 145 2 who who WP cord-354168-omen8vvq 145 3 achieve achieve VBP cord-354168-omen8vvq 145 4 sustained sustain VBN cord-354168-omen8vvq 145 5 very very RB cord-354168-omen8vvq 145 6 good good JJ cord-354168-omen8vvq 145 7 partial partial JJ cord-354168-omen8vvq 145 8 response response NN cord-354168-omen8vvq 145 9 or or CC cord-354168-omen8vvq 145 10 better well JJR cord-354168-omen8vvq 145 11 ( ( -LRB- cord-354168-omen8vvq 145 12 ≥VGPR ≥vgpr NN cord-354168-omen8vvq 145 13 ) ) -RRB- cord-354168-omen8vvq 145 14 after after IN cord-354168-omen8vvq 145 15 3 3 CD cord-354168-omen8vvq 145 16 - - SYM cord-354168-omen8vvq 145 17 4 4 CD cord-354168-omen8vvq 145 18 cycles cycle NNS cord-354168-omen8vvq 145 19 , , , cord-354168-omen8vvq 145 20 the the DT cord-354168-omen8vvq 145 21 doses dose NNS cord-354168-omen8vvq 145 22 of of IN cord-354168-omen8vvq 145 23 dexamethasone dexamethasone NN cord-354168-omen8vvq 145 24 should should MD cord-354168-omen8vvq 145 25 be be VB cord-354168-omen8vvq 145 26 decreased decrease VBN cord-354168-omen8vvq 145 27 further further RB cord-354168-omen8vvq 145 28 to to IN cord-354168-omen8vvq 145 29 12 12 CD cord-354168-omen8vvq 145 30 mg mg NN cord-354168-omen8vvq 145 31 with with IN cord-354168-omen8vvq 145 32 monitoring monitoring NN cord-354168-omen8vvq 145 33 of of IN cord-354168-omen8vvq 145 34 response response NN cord-354168-omen8vvq 145 35 . . . cord-354168-omen8vvq 146 1 If if IN cord-354168-omen8vvq 146 2 the the DT cord-354168-omen8vvq 146 3 concerns concern NNS cord-354168-omen8vvq 146 4 regarding regard VBG cord-354168-omen8vvq 146 5 COVID-19 covid-19 CD cord-354168-omen8vvq 146 6 continue continue VB cord-354168-omen8vvq 146 7 , , , cord-354168-omen8vvq 146 8 and and CC cord-354168-omen8vvq 146 9 the the DT cord-354168-omen8vvq 146 10 patient patient NN cord-354168-omen8vvq 146 11 is be VBZ cord-354168-omen8vvq 146 12 on on IN cord-354168-omen8vvq 146 13 bortezomib bortezomib NNP cord-354168-omen8vvq 146 14 , , , cord-354168-omen8vvq 146 15 the the DT cord-354168-omen8vvq 146 16 frequency frequency NN cord-354168-omen8vvq 146 17 of of IN cord-354168-omen8vvq 146 18 administration administration NN cord-354168-omen8vvq 146 19 can can MD cord-354168-omen8vvq 146 20 be be VB cord-354168-omen8vvq 146 21 decreased decrease VBN cord-354168-omen8vvq 146 22 to to IN cord-354168-omen8vvq 146 23 every every DT cord-354168-omen8vvq 146 24 other other JJ cord-354168-omen8vvq 146 25 week week NN cord-354168-omen8vvq 146 26 after after IN cord-354168-omen8vvq 146 27 6 6 CD cord-354168-omen8vvq 146 28 - - SYM cord-354168-omen8vvq 146 29 8 8 CD cord-354168-omen8vvq 146 30 cycles cycle NNS cord-354168-omen8vvq 146 31 ( ( -LRB- cord-354168-omen8vvq 146 32 if if IN cord-354168-omen8vvq 146 33 response response NN cord-354168-omen8vvq 146 34 is be VBZ cord-354168-omen8vvq 146 35 ≥VGPR ≥vgpr NN cord-354168-omen8vvq 146 36 and and CC cord-354168-omen8vvq 146 37 is be VBZ cord-354168-omen8vvq 146 38 sustained sustain VBN cord-354168-omen8vvq 146 39 ) ) -RRB- cord-354168-omen8vvq 146 40 . . . cord-354168-omen8vvq 147 1 If if IN cord-354168-omen8vvq 147 2 the the DT cord-354168-omen8vvq 147 3 patient patient NN cord-354168-omen8vvq 147 4 is be VBZ cord-354168-omen8vvq 147 5 on on IN cord-354168-omen8vvq 147 6 daratumumabbased daratumumabbase VBN cord-354168-omen8vvq 147 7 therapy therapy NN cord-354168-omen8vvq 147 8 ( ( -LRB- cord-354168-omen8vvq 147 9 DRd DRd NNS cord-354168-omen8vvq 147 10 ) ) -RRB- cord-354168-omen8vvq 147 11 and and CC cord-354168-omen8vvq 147 12 has have VBZ cord-354168-omen8vvq 147 13 achieved achieve VBN cord-354168-omen8vvq 147 14 ≥VGPR ≥vgpr NN cord-354168-omen8vvq 147 15 after after IN cord-354168-omen8vvq 147 16 the the DT cord-354168-omen8vvq 147 17 second second JJ cord-354168-omen8vvq 147 18 cycle cycle NN cord-354168-omen8vvq 147 19 , , , cord-354168-omen8vvq 147 20 we -PRON- PRP cord-354168-omen8vvq 147 21 would would MD cord-354168-omen8vvq 147 22 recommend recommend VB cord-354168-omen8vvq 147 23 continuing continue VBG cord-354168-omen8vvq 147 24 the the DT cord-354168-omen8vvq 147 25 cycle cycle NN cord-354168-omen8vvq 147 26 every every DT cord-354168-omen8vvq 147 27 28 28 CD cord-354168-omen8vvq 147 28 days day NNS cord-354168-omen8vvq 147 29 , , , cord-354168-omen8vvq 147 30 but but CC cord-354168-omen8vvq 147 31 change change VB cord-354168-omen8vvq 147 32 the the DT cord-354168-omen8vvq 147 33 daratumumab daratumumab NN cord-354168-omen8vvq 147 34 to to IN cord-354168-omen8vvq 147 35 every every DT cord-354168-omen8vvq 147 36 4 4 CD cord-354168-omen8vvq 147 37 weeks week NNS cord-354168-omen8vvq 147 38 rather rather RB cord-354168-omen8vvq 147 39 than than IN cord-354168-omen8vvq 147 40 every every DT cord-354168-omen8vvq 147 41 2 2 CD cord-354168-omen8vvq 147 42 weeks week NNS cord-354168-omen8vvq 147 43 . . . cord-354168-omen8vvq 148 1 After after IN cord-354168-omen8vvq 148 2 10 10 CD cord-354168-omen8vvq 148 3 - - SYM cord-354168-omen8vvq 148 4 12 12 CD cord-354168-omen8vvq 148 5 cycles cycle NNS cord-354168-omen8vvq 148 6 and and CC cord-354168-omen8vvq 148 7 if if IN cord-354168-omen8vvq 148 8 the the DT cord-354168-omen8vvq 148 9 goals goal NNS cord-354168-omen8vvq 148 10 of of IN cord-354168-omen8vvq 148 11 therapy therapy NN cord-354168-omen8vvq 148 12 are be VBP cord-354168-omen8vvq 148 13 achieved achieve VBN cord-354168-omen8vvq 148 14 , , , cord-354168-omen8vvq 148 15 switching switch VBG cord-354168-omen8vvq 148 16 to to IN cord-354168-omen8vvq 148 17 maintenance maintenance NN cord-354168-omen8vvq 148 18 therapy therapy NN cord-354168-omen8vvq 148 19 with with IN cord-354168-omen8vvq 148 20 lenalidomide lenalidomide NN cord-354168-omen8vvq 148 21 can can MD cord-354168-omen8vvq 148 22 be be VB cord-354168-omen8vvq 148 23 considered consider VBN cord-354168-omen8vvq 148 24 . . . cord-354168-omen8vvq 149 1 Overall overall RB cord-354168-omen8vvq 149 2 , , , cord-354168-omen8vvq 149 3 we -PRON- PRP cord-354168-omen8vvq 149 4 believe believe VBP cord-354168-omen8vvq 149 5 that that IN cord-354168-omen8vvq 149 6 these these DT cord-354168-omen8vvq 149 7 patients patient NNS cord-354168-omen8vvq 149 8 should should MD cord-354168-omen8vvq 149 9 continue continue VB cord-354168-omen8vvq 149 10 on on IN cord-354168-omen8vvq 149 11 their -PRON- PRP$ cord-354168-omen8vvq 149 12 triplet triplet NN cord-354168-omen8vvq 149 13 therapy therapy NN cord-354168-omen8vvq 149 14 for for IN cord-354168-omen8vvq 149 15 10 10 CD cord-354168-omen8vvq 149 16 - - SYM cord-354168-omen8vvq 149 17 12 12 CD cord-354168-omen8vvq 149 18 months month NNS cord-354168-omen8vvq 149 19 . . . cord-354168-omen8vvq 150 1 The the DT cord-354168-omen8vvq 150 2 dose dose NN cord-354168-omen8vvq 150 3 of of IN cord-354168-omen8vvq 150 4 dexamethasone dexamethasone NN cord-354168-omen8vvq 150 5 can can MD cord-354168-omen8vvq 150 6 be be VB cord-354168-omen8vvq 150 7 decreased decrease VBN cord-354168-omen8vvq 150 8 after after IN cord-354168-omen8vvq 150 9 4 4 CD cord-354168-omen8vvq 150 10 - - SYM cord-354168-omen8vvq 150 11 6 6 CD cord-354168-omen8vvq 150 12 cycles cycle NNS cord-354168-omen8vvq 150 13 if if IN cord-354168-omen8vvq 150 14 sustained sustain VBD cord-354168-omen8vvq 150 15 deep deep JJ cord-354168-omen8vvq 150 16 responses response NNS cord-354168-omen8vvq 150 17 ( ( -LRB- cord-354168-omen8vvq 150 18 ≥VGPR ≥vgpr NN cord-354168-omen8vvq 150 19 ) ) -RRB- cord-354168-omen8vvq 150 20 are be VBP cord-354168-omen8vvq 150 21 achieved achieve VBN cord-354168-omen8vvq 150 22 . . . cord-354168-omen8vvq 151 1 The the DT cord-354168-omen8vvq 151 2 frequency frequency NN cord-354168-omen8vvq 151 3 of of IN cord-354168-omen8vvq 151 4 PIs pi NNS cord-354168-omen8vvq 151 5 can can MD cord-354168-omen8vvq 151 6 be be VB cord-354168-omen8vvq 151 7 reduced reduce VBN cord-354168-omen8vvq 151 8 to to IN cord-354168-omen8vvq 151 9 every every DT cord-354168-omen8vvq 151 10 2 2 CD cord-354168-omen8vvq 151 11 weeks week NNS cord-354168-omen8vvq 151 12 , , , cord-354168-omen8vvq 151 13 if if IN cord-354168-omen8vvq 151 14 the the DT cord-354168-omen8vvq 151 15 response response NN cord-354168-omen8vvq 151 16 is be VBZ cord-354168-omen8vvq 151 17 sustained sustain VBN cord-354168-omen8vvq 151 18 . . . cord-354168-omen8vvq 152 1 After after IN cord-354168-omen8vvq 152 2 10 10 CD cord-354168-omen8vvq 152 3 - - SYM cord-354168-omen8vvq 152 4 12 12 CD cord-354168-omen8vvq 152 5 cycles cycle NNS cord-354168-omen8vvq 152 6 , , , cord-354168-omen8vvq 152 7 we -PRON- PRP cord-354168-omen8vvq 152 8 would would MD cord-354168-omen8vvq 152 9 recommend recommend VB cord-354168-omen8vvq 152 10 PI PI NNP cord-354168-omen8vvq 152 11 - - HYPH cord-354168-omen8vvq 152 12 based base VBN cord-354168-omen8vvq 152 13 maintenance maintenance NN cord-354168-omen8vvq 152 14 with with IN cord-354168-omen8vvq 152 15 bortezomib bortezomib NNP cord-354168-omen8vvq 152 16 subcutaneously subcutaneously RB cord-354168-omen8vvq 152 17 every every DT cord-354168-omen8vvq 152 18 2 2 CD cord-354168-omen8vvq 152 19 weeks week NNS cord-354168-omen8vvq 152 20 or or CC cord-354168-omen8vvq 152 21 weekly weekly JJ cord-354168-omen8vvq 152 22 ixazomib ixazomib NNS cord-354168-omen8vvq 152 23 . . . cord-354168-omen8vvq 153 1 Those those DT cord-354168-omen8vvq 153 2 patients patient NNS cord-354168-omen8vvq 153 3 should should MD cord-354168-omen8vvq 153 4 undergo undergo VB cord-354168-omen8vvq 153 5 ASCT ASCT NNP cord-354168-omen8vvq 153 6 as as RB cord-354168-omen8vvq 153 7 soon soon RB cord-354168-omen8vvq 153 8 as as IN cord-354168-omen8vvq 153 9 the the DT cord-354168-omen8vvq 153 10 pandemic pandemic NN cord-354168-omen8vvq 153 11 resolves resolve VBZ cord-354168-omen8vvq 153 12 . . . cord-354168-omen8vvq 154 1 If if IN cord-354168-omen8vvq 154 2 DRd DRd NNS cord-354168-omen8vvq 154 3 is be VBZ cord-354168-omen8vvq 154 4 available available JJ cord-354168-omen8vvq 154 5 , , , cord-354168-omen8vvq 154 6 we -PRON- PRP cord-354168-omen8vvq 154 7 would would MD cord-354168-omen8vvq 154 8 recommend recommend VB cord-354168-omen8vvq 154 9 it -PRON- PRP cord-354168-omen8vvq 154 10 for for IN cord-354168-omen8vvq 154 11 these these DT cord-354168-omen8vvq 154 12 patients patient NNS cord-354168-omen8vvq 154 13 if if IN cord-354168-omen8vvq 154 14 weekly weekly JJ cord-354168-omen8vvq 154 15 clinic clinic NN cord-354168-omen8vvq 154 16 visits visit NNS cord-354168-omen8vvq 154 17 are be VBP cord-354168-omen8vvq 154 18 feasible feasible JJ cord-354168-omen8vvq 154 19 and and CC cord-354168-omen8vvq 154 20 safe safe JJ cord-354168-omen8vvq 154 21 . . . cord-354168-omen8vvq 155 1 If if IN cord-354168-omen8vvq 155 2 not not RB cord-354168-omen8vvq 155 3 , , , cord-354168-omen8vvq 155 4 using use VBG cord-354168-omen8vvq 155 5 a a DT cord-354168-omen8vvq 155 6 triplet triplet NN cord-354168-omen8vvq 155 7 , , , cord-354168-omen8vvq 155 8 such such JJ cord-354168-omen8vvq 155 9 as as IN cord-354168-omen8vvq 155 10 IRd IRd NNP cord-354168-omen8vvq 155 11 ( ( -LRB- cord-354168-omen8vvq 155 12 preferred prefer VBN cord-354168-omen8vvq 155 13 ) ) -RRB- cord-354168-omen8vvq 155 14 , , , cord-354168-omen8vvq 155 15 CRd CRd NNS cord-354168-omen8vvq 155 16 , , , cord-354168-omen8vvq 155 17 RVd rvd NN cord-354168-omen8vvq 155 18 , , , cord-354168-omen8vvq 155 19 or or CC cord-354168-omen8vvq 155 20 CyBorD CyBorD NNP cord-354168-omen8vvq 155 21 can can MD cord-354168-omen8vvq 155 22 also also RB cord-354168-omen8vvq 155 23 be be VB cord-354168-omen8vvq 155 24 considered consider VBN cord-354168-omen8vvq 155 25 , , , cord-354168-omen8vvq 155 26 depending depend VBG cord-354168-omen8vvq 155 27 on on IN cord-354168-omen8vvq 155 28 availability availability NN cord-354168-omen8vvq 155 29 . . . cord-354168-omen8vvq 156 1 These these DT cord-354168-omen8vvq 156 2 patients patient NNS cord-354168-omen8vvq 156 3 frequently frequently RB cord-354168-omen8vvq 156 4 require require VBP cord-354168-omen8vvq 156 5 dose dose JJ cord-354168-omen8vvq 156 6 adjustments adjustment NNS cord-354168-omen8vvq 156 7 and and CC cord-354168-omen8vvq 156 8 close close JJ cord-354168-omen8vvq 156 9 monitoring monitoring NN cord-354168-omen8vvq 156 10 is be VBZ cord-354168-omen8vvq 156 11 recommended recommend VBN cord-354168-omen8vvq 156 12 . . . cord-354168-omen8vvq 157 1 Most Most JJS cord-354168-omen8vvq 157 2 patients patient NNS cord-354168-omen8vvq 157 3 with with IN cord-354168-omen8vvq 157 4 MM MM NNP cord-354168-omen8vvq 157 5 will will MD cord-354168-omen8vvq 157 6 relapse relapse VB cord-354168-omen8vvq 157 7 and and CC cord-354168-omen8vvq 157 8 the the DT cord-354168-omen8vvq 157 9 management management NN cord-354168-omen8vvq 157 10 of of IN cord-354168-omen8vvq 157 11 relapse relapse NN cord-354168-omen8vvq 157 12 should should MD cord-354168-omen8vvq 157 13 be be VB cord-354168-omen8vvq 157 14 individualized individualize VBN cord-354168-omen8vvq 157 15 depending depend VBG cord-354168-omen8vvq 157 16 on on IN cord-354168-omen8vvq 157 17 the the DT cord-354168-omen8vvq 157 18 patient patient NN cord-354168-omen8vvq 157 19 , , , cord-354168-omen8vvq 157 20 as as IN cord-354168-omen8vvq 157 21 not not RB cord-354168-omen8vvq 157 22 all all DT cord-354168-omen8vvq 157 23 relapses relapse NNS cord-354168-omen8vvq 157 24 biologically biologically RB cord-354168-omen8vvq 157 25 behave behave VBP cord-354168-omen8vvq 157 26 the the DT cord-354168-omen8vvq 157 27 same same JJ cord-354168-omen8vvq 157 28 . . . cord-354168-omen8vvq 158 1 A a DT cord-354168-omen8vvq 158 2 discussion discussion NN cord-354168-omen8vvq 158 3 regarding regard VBG cord-354168-omen8vvq 158 4 the the DT cord-354168-omen8vvq 158 5 management management NN cord-354168-omen8vvq 158 6 of of IN cord-354168-omen8vvq 158 7 relapsed relapse VBN cord-354168-omen8vvq 158 8 MM MM NNP cord-354168-omen8vvq 158 9 patients patient NNS cord-354168-omen8vvq 158 10 is be VBZ cord-354168-omen8vvq 158 11 beyond beyond IN cord-354168-omen8vvq 158 12 the the DT cord-354168-omen8vvq 158 13 scope scope NN cord-354168-omen8vvq 158 14 of of IN cord-354168-omen8vvq 158 15 this this DT cord-354168-omen8vvq 158 16 review review NN cord-354168-omen8vvq 158 17 . . . cord-354168-omen8vvq 159 1 We -PRON- PRP cord-354168-omen8vvq 159 2 recommend recommend VBP cord-354168-omen8vvq 159 3 viewing view VBG cord-354168-omen8vvq 159 4 the the DT cord-354168-omen8vvq 159 5 mSMART mSMART NNP cord-354168-omen8vvq 159 6 guidelines guideline NNS cord-354168-omen8vvq 159 7 from from IN cord-354168-omen8vvq 159 8 our -PRON- PRP$ cord-354168-omen8vvq 159 9 institution institution NN cord-354168-omen8vvq 159 10 [ [ -LRB- cord-354168-omen8vvq 159 11 37 37 CD cord-354168-omen8vvq 159 12 ] ] -RRB- cord-354168-omen8vvq 159 13 . . . cord-354168-omen8vvq 160 1 Key key JJ cord-354168-omen8vvq 160 2 points point NNS cord-354168-omen8vvq 160 3 are be VBP cord-354168-omen8vvq 160 4 described describe VBN cord-354168-omen8vvq 160 5 below below RB cord-354168-omen8vvq 160 6 : : : cord-354168-omen8vvq 160 7 For for IN cord-354168-omen8vvq 160 8 those those DT cord-354168-omen8vvq 160 9 patients patient NNS cord-354168-omen8vvq 160 10 who who WP cord-354168-omen8vvq 160 11 relapse relapse VBP cord-354168-omen8vvq 160 12 late late RB cord-354168-omen8vvq 160 13 from from IN cord-354168-omen8vvq 160 14 diagnosis diagnosis NN cord-354168-omen8vvq 160 15 with with IN cord-354168-omen8vvq 160 16 no no DT cord-354168-omen8vvq 160 17 high high JJ cord-354168-omen8vvq 160 18 - - HYPH cord-354168-omen8vvq 160 19 risk risk NN cord-354168-omen8vvq 160 20 genetic genetic JJ cord-354168-omen8vvq 160 21 features feature NNS cord-354168-omen8vvq 160 22 and and CC cord-354168-omen8vvq 160 23 who who WP cord-354168-omen8vvq 160 24 did do VBD cord-354168-omen8vvq 160 25 not not RB cord-354168-omen8vvq 160 26 receive receive VB cord-354168-omen8vvq 160 27 daratumumab daratumumab NNP cord-354168-omen8vvq 160 28 as as IN cord-354168-omen8vvq 160 29 part part NN cord-354168-omen8vvq 160 30 of of IN cord-354168-omen8vvq 160 31 the the DT cord-354168-omen8vvq 160 32 induction induction NN cord-354168-omen8vvq 160 33 , , , cord-354168-omen8vvq 160 34 we -PRON- PRP cord-354168-omen8vvq 160 35 would would MD cord-354168-omen8vvq 160 36 recommend recommend VB cord-354168-omen8vvq 160 37 daratumumab daratumumab NNP cord-354168-omen8vvq 160 38 - - HYPH cord-354168-omen8vvq 160 39 based base VBN cord-354168-omen8vvq 160 40 regimens regimen NNS cord-354168-omen8vvq 160 41 . . . cord-354168-omen8vvq 161 1 If if IN cord-354168-omen8vvq 161 2 the the DT cord-354168-omen8vvq 161 3 patient patient NN cord-354168-omen8vvq 161 4 responds respond VBZ cord-354168-omen8vvq 161 5 well well RB cord-354168-omen8vvq 161 6 and and CC cord-354168-omen8vvq 161 7 is be VBZ cord-354168-omen8vvq 161 8 stable stable JJ cord-354168-omen8vvq 161 9 , , , cord-354168-omen8vvq 161 10 recommendations recommendation NNS cord-354168-omen8vvq 161 11 regarding regard VBG cord-354168-omen8vvq 161 12 dose dose JJ cord-354168-omen8vvq 161 13 adjustment adjustment NN cord-354168-omen8vvq 161 14 can can MD cord-354168-omen8vvq 161 15 be be VB cord-354168-omen8vvq 161 16 followed follow VBN cord-354168-omen8vvq 161 17 as as IN cord-354168-omen8vvq 161 18 for for IN cord-354168-omen8vvq 161 19 newly newly RB cord-354168-omen8vvq 161 20 diagnosed diagnose VBN cord-354168-omen8vvq 161 21 patients patient NNS cord-354168-omen8vvq 161 22 ( ( -LRB- cord-354168-omen8vvq 161 23 above above RB cord-354168-omen8vvq 161 24 ) ) -RRB- cord-354168-omen8vvq 161 25 . . . cord-354168-omen8vvq 162 1 We -PRON- PRP cord-354168-omen8vvq 162 2 would would MD cord-354168-omen8vvq 162 3 not not RB cord-354168-omen8vvq 162 4 recommend recommend VB cord-354168-omen8vvq 162 5 proceeding proceed VBG cord-354168-omen8vvq 162 6 directly directly RB cord-354168-omen8vvq 162 7 with with IN cord-354168-omen8vvq 162 8 ASCT ASCT NNP cord-354168-omen8vvq 163 1 ( ( -LRB- cord-354168-omen8vvq 163 2 if if IN cord-354168-omen8vvq 163 3 it -PRON- PRP cord-354168-omen8vvq 163 4 was be VBD cord-354168-omen8vvq 163 5 part part NN cord-354168-omen8vvq 163 6 of of IN cord-354168-omen8vvq 163 7 the the DT cord-354168-omen8vvq 163 8 treatment treatment NN cord-354168-omen8vvq 163 9 plan plan NN cord-354168-omen8vvq 163 10 ) ) -RRB- cord-354168-omen8vvq 163 11 until until IN cord-354168-omen8vvq 163 12 the the DT cord-354168-omen8vvq 163 13 current current JJ cord-354168-omen8vvq 163 14 pandemic pandemic NN cord-354168-omen8vvq 163 15 resolves resolve VBZ cord-354168-omen8vvq 163 16 . . . cord-354168-omen8vvq 164 1 If if IN cord-354168-omen8vvq 164 2 daratumumab daratumumab NNP cord-354168-omen8vvq 164 3 is be VBZ cord-354168-omen8vvq 164 4 not not RB cord-354168-omen8vvq 164 5 available available JJ cord-354168-omen8vvq 164 6 , , , cord-354168-omen8vvq 164 7 other other JJ cord-354168-omen8vvq 164 8 triplet triplet NN cord-354168-omen8vvq 164 9 combinations combination NNS cord-354168-omen8vvq 164 10 should should MD cord-354168-omen8vvq 164 11 be be VB cord-354168-omen8vvq 164 12 used use VBN cord-354168-omen8vvq 164 13 depending depend VBG cord-354168-omen8vvq 164 14 on on IN cord-354168-omen8vvq 164 15 availability availability NN cord-354168-omen8vvq 164 16 , , , cord-354168-omen8vvq 164 17 fitness fitness NN cord-354168-omen8vvq 164 18 of of IN cord-354168-omen8vvq 164 19 the the DT cord-354168-omen8vvq 164 20 patient patient NN cord-354168-omen8vvq 164 21 , , , cord-354168-omen8vvq 164 22 and and CC cord-354168-omen8vvq 164 23 type type NN cord-354168-omen8vvq 164 24 of of IN cord-354168-omen8vvq 164 25 maintenance maintenance NN cord-354168-omen8vvq 164 26 therapy therapy NN cord-354168-omen8vvq 164 27 . . . cord-354168-omen8vvq 165 1 If if IN cord-354168-omen8vvq 165 2 the the DT cord-354168-omen8vvq 165 3 patient patient NN cord-354168-omen8vvq 165 4 is be VBZ cord-354168-omen8vvq 165 5 not not RB cord-354168-omen8vvq 165 6 responding respond VBG cord-354168-omen8vvq 165 7 well well RB cord-354168-omen8vvq 165 8 and and CC cord-354168-omen8vvq 165 9 is be VBZ cord-354168-omen8vvq 165 10 failing fail VBG cord-354168-omen8vvq 165 11 conventional conventional JJ cord-354168-omen8vvq 165 12 therapy therapy NN cord-354168-omen8vvq 165 13 , , , cord-354168-omen8vvq 165 14 ASCT ASCT NNP cord-354168-omen8vvq 165 15 can can MD cord-354168-omen8vvq 165 16 be be VB cord-354168-omen8vvq 165 17 considered consider VBN cord-354168-omen8vvq 165 18 as as IN cord-354168-omen8vvq 165 19 salvage salvage NN cord-354168-omen8vvq 165 20 . . . cord-354168-omen8vvq 166 1 A a DT cord-354168-omen8vvq 166 2 reminder reminder NN cord-354168-omen8vvq 166 3 : : : cord-354168-omen8vvq 166 4 these these DT cord-354168-omen8vvq 166 5 patients patient NNS cord-354168-omen8vvq 166 6 should should MD cord-354168-omen8vvq 166 7 be be VB cord-354168-omen8vvq 166 8 screened screen VBN cord-354168-omen8vvq 166 9 for for IN cord-354168-omen8vvq 166 10 COV COV NNP cord-354168-omen8vvq 166 11 - - HYPH cord-354168-omen8vvq 166 12 ID-19 ID-19 NNP cord-354168-omen8vvq 166 13 before before IN cord-354168-omen8vvq 166 14 ASCT ASCT NNP cord-354168-omen8vvq 166 15 . . . cord-354168-omen8vvq 167 1 These these DT cord-354168-omen8vvq 167 2 patients patient NNS cord-354168-omen8vvq 167 3 are be VBP cord-354168-omen8vvq 167 4 the the DT cord-354168-omen8vvq 167 5 most most RBS cord-354168-omen8vvq 167 6 difficult difficult JJ cord-354168-omen8vvq 167 7 to to TO cord-354168-omen8vvq 167 8 manage manage VB cord-354168-omen8vvq 167 9 with with IN cord-354168-omen8vvq 167 10 the the DT cord-354168-omen8vvq 167 11 current current JJ cord-354168-omen8vvq 167 12 situation situation NN cord-354168-omen8vvq 167 13 . . . cord-354168-omen8vvq 168 1 The the DT cord-354168-omen8vvq 168 2 management management NN cord-354168-omen8vvq 168 3 will will MD cord-354168-omen8vvq 168 4 depend depend VB cord-354168-omen8vvq 168 5 on on IN cord-354168-omen8vvq 168 6 the the DT cord-354168-omen8vvq 168 7 nature nature NN cord-354168-omen8vvq 168 8 of of IN cord-354168-omen8vvq 168 9 relapse relapse NN cord-354168-omen8vvq 168 10 and and CC cord-354168-omen8vvq 168 11 how how WRB cord-354168-omen8vvq 168 12 aggressive aggressive JJ cord-354168-omen8vvq 168 13 it -PRON- PRP cord-354168-omen8vvq 168 14 is be VBZ cord-354168-omen8vvq 168 15 . . . cord-354168-omen8vvq 169 1 Again again RB cord-354168-omen8vvq 169 2 , , , cord-354168-omen8vvq 169 3 if if IN cord-354168-omen8vvq 169 4 patients patient NNS cord-354168-omen8vvq 169 5 did do VBD cord-354168-omen8vvq 169 6 not not RB cord-354168-omen8vvq 169 7 receive receive VB cord-354168-omen8vvq 169 8 daratumumab daratumumab NNP cord-354168-omen8vvq 169 9 , , , cord-354168-omen8vvq 169 10 daratumumabbased daratumumabbased JJ cord-354168-omen8vvq 169 11 treatment treatment NN cord-354168-omen8vvq 169 12 should should MD cord-354168-omen8vvq 169 13 be be VB cord-354168-omen8vvq 169 14 used use VBN cord-354168-omen8vvq 169 15 . . . cord-354168-omen8vvq 170 1 If if IN cord-354168-omen8vvq 170 2 daratumumab daratumumab NNP cord-354168-omen8vvq 170 3 is be VBZ cord-354168-omen8vvq 170 4 not not RB cord-354168-omen8vvq 170 5 available available JJ cord-354168-omen8vvq 170 6 , , , cord-354168-omen8vvq 170 7 other other JJ cord-354168-omen8vvq 170 8 triplet triplet NN cord-354168-omen8vvq 170 9 combinations combination NNS cord-354168-omen8vvq 170 10 should should MD cord-354168-omen8vvq 170 11 be be VB cord-354168-omen8vvq 170 12 considered consider VBN cord-354168-omen8vvq 170 13 depending depend VBG cord-354168-omen8vvq 170 14 on on IN cord-354168-omen8vvq 170 15 availability availability NN cord-354168-omen8vvq 170 16 , , , cord-354168-omen8vvq 170 17 fitness fitness NN cord-354168-omen8vvq 170 18 of of IN cord-354168-omen8vvq 170 19 the the DT cord-354168-omen8vvq 170 20 patient patient NN cord-354168-omen8vvq 170 21 , , , cord-354168-omen8vvq 170 22 and and CC cord-354168-omen8vvq 170 23 type type NN cord-354168-omen8vvq 170 24 of of IN cord-354168-omen8vvq 170 25 maintenance maintenance NN cord-354168-omen8vvq 170 26 therapy therapy NN cord-354168-omen8vvq 170 27 . . . cord-354168-omen8vvq 171 1 The the DT cord-354168-omen8vvq 171 2 decision decision NN cord-354168-omen8vvq 171 3 regarding regard VBG cord-354168-omen8vvq 171 4 ASCT ASCT NNP cord-354168-omen8vvq 171 5 should should MD cord-354168-omen8vvq 171 6 be be VB cord-354168-omen8vvq 171 7 individualized individualize VBN cord-354168-omen8vvq 171 8 . . . cord-354168-omen8vvq 172 1 For for IN cord-354168-omen8vvq 172 2 patients patient NNS cord-354168-omen8vvq 172 3 with with IN cord-354168-omen8vvq 172 4 aggressive aggressive JJ cord-354168-omen8vvq 172 5 relapse relapse NN cord-354168-omen8vvq 172 6 ( ( -LRB- cord-354168-omen8vvq 172 7 especially especially RB cord-354168-omen8vvq 172 8 with with IN cord-354168-omen8vvq 172 9 suboptimal suboptimal JJ cord-354168-omen8vvq 172 10 responses response NNS cord-354168-omen8vvq 172 11 to to TO cord-354168-omen8vvq 172 12 salvage salvage VB cord-354168-omen8vvq 172 13 therapy therapy NN cord-354168-omen8vvq 172 14 ) ) -RRB- cord-354168-omen8vvq 172 15 , , , cord-354168-omen8vvq 172 16 ASCT ASCT NNP cord-354168-omen8vvq 172 17 should should MD cord-354168-omen8vvq 172 18 be be VB cord-354168-omen8vvq 172 19 considered consider VBN cord-354168-omen8vvq 172 20 as as IN cord-354168-omen8vvq 172 21 salvage salvage NN cord-354168-omen8vvq 172 22 . . . cord-354168-omen8vvq 173 1 These these DT cord-354168-omen8vvq 173 2 patients patient NNS cord-354168-omen8vvq 173 3 should should MD cord-354168-omen8vvq 173 4 be be VB cord-354168-omen8vvq 173 5 screened screen VBN cord-354168-omen8vvq 173 6 for for IN cord-354168-omen8vvq 173 7 COVID-19 COVID-19 NNP cord-354168-omen8vvq 173 8 before before IN cord-354168-omen8vvq 173 9 ASCT ASCT NNP cord-354168-omen8vvq 173 10 . . . cord-354168-omen8vvq 174 1 For for IN cord-354168-omen8vvq 174 2 patients patient NNS cord-354168-omen8vvq 174 3 who who WP cord-354168-omen8vvq 174 4 relapse relapse VBP cord-354168-omen8vvq 174 5 slowly slowly RB cord-354168-omen8vvq 174 6 and and CC cord-354168-omen8vvq 174 7 achieve achieve VB cord-354168-omen8vvq 174 8 deep deep JJ cord-354168-omen8vvq 174 9 responses response NNS cord-354168-omen8vvq 174 10 ( ( -LRB- cord-354168-omen8vvq 174 11 ≥VGPR ≥vgpr NN cord-354168-omen8vvq 174 12 ) ) -RRB- cord-354168-omen8vvq 174 13 after after IN cord-354168-omen8vvq 174 14 therapy therapy NN cord-354168-omen8vvq 174 15 , , , cord-354168-omen8vvq 174 16 ASCT ASCT NNP cord-354168-omen8vvq 174 17 should should MD cord-354168-omen8vvq 174 18 be be VB cord-354168-omen8vvq 174 19 delayed delay VBN cord-354168-omen8vvq 174 20 . . . cord-354168-omen8vvq 175 1 Patients patient NNS cord-354168-omen8vvq 175 2 with with IN cord-354168-omen8vvq 175 3 secondary secondary JJ cord-354168-omen8vvq 175 4 PCL PCL NNP cord-354168-omen8vvq 175 5 ( ( -LRB- cord-354168-omen8vvq 175 6 in in IN cord-354168-omen8vvq 175 7 the the DT cord-354168-omen8vvq 175 8 setting setting NN cord-354168-omen8vvq 175 9 of of IN cord-354168-omen8vvq 175 10 refractory refractory JJ cord-354168-omen8vvq 175 11 / / SYM cord-354168-omen8vvq 175 12 relapsed relapse VBN cord-354168-omen8vvq 175 13 MM MM NNP cord-354168-omen8vvq 175 14 ) ) -RRB- cord-354168-omen8vvq 175 15 have have VBP cord-354168-omen8vvq 175 16 a a DT cord-354168-omen8vvq 175 17 grim grim JJ cord-354168-omen8vvq 175 18 prognosis prognosis NN cord-354168-omen8vvq 175 19 [ [ -LRB- cord-354168-omen8vvq 175 20 38 38 CD cord-354168-omen8vvq 175 21 ] ] -RRB- cord-354168-omen8vvq 175 22 . . . cord-354168-omen8vvq 176 1 These these DT cord-354168-omen8vvq 176 2 patients patient NNS cord-354168-omen8vvq 176 3 should should MD cord-354168-omen8vvq 176 4 receive receive VB cord-354168-omen8vvq 176 5 myeloma myeloma NN cord-354168-omen8vvq 176 6 - - HYPH cord-354168-omen8vvq 176 7 directed direct VBN cord-354168-omen8vvq 176 8 therapy therapy NN cord-354168-omen8vvq 176 9 followed follow VBN cord-354168-omen8vvq 176 10 by by IN cord-354168-omen8vvq 176 11 ASCT ASCT NNP cord-354168-omen8vvq 176 12 . . . cord-354168-omen8vvq 177 1 Testing test VBG cord-354168-omen8vvq 177 2 for for IN cord-354168-omen8vvq 177 3 COVID-19 COVID-19 NNP cord-354168-omen8vvq 177 4 should should MD cord-354168-omen8vvq 177 5 be be VB cord-354168-omen8vvq 177 6 done do VBN cord-354168-omen8vvq 177 7 before before IN cord-354168-omen8vvq 177 8 ASCT ASCT NNP cord-354168-omen8vvq 177 9 . . . cord-354168-omen8vvq 178 1 We -PRON- PRP cord-354168-omen8vvq 178 2 believe believe VBP cord-354168-omen8vvq 178 3 that that IN cord-354168-omen8vvq 178 4 patients patient NNS cord-354168-omen8vvq 178 5 who who WP cord-354168-omen8vvq 178 6 are be VBP cord-354168-omen8vvq 178 7 stable stable JJ cord-354168-omen8vvq 178 8 on on IN cord-354168-omen8vvq 178 9 maintenance maintenance NN cord-354168-omen8vvq 178 10 with with IN cord-354168-omen8vvq 178 11 no no DT cord-354168-omen8vvq 178 12 major major JJ cord-354168-omen8vvq 178 13 side side NN cord-354168-omen8vvq 178 14 effects effect NNS cord-354168-omen8vvq 178 15 should should MD cord-354168-omen8vvq 178 16 continue continue VB cord-354168-omen8vvq 178 17 on on IN cord-354168-omen8vvq 178 18 their -PRON- PRP$ cord-354168-omen8vvq 178 19 maintenance maintenance NN cord-354168-omen8vvq 178 20 . . . cord-354168-omen8vvq 179 1 If if IN cord-354168-omen8vvq 179 2 the the DT cord-354168-omen8vvq 179 3 patient patient NN cord-354168-omen8vvq 179 4 is be VBZ cord-354168-omen8vvq 179 5 on on IN cord-354168-omen8vvq 179 6 dexamethasone dexamethasone NN cord-354168-omen8vvq 179 7 during during IN cord-354168-omen8vvq 179 8 their -PRON- PRP$ cord-354168-omen8vvq 179 9 maintenance maintenance NN cord-354168-omen8vvq 179 10 , , , cord-354168-omen8vvq 179 11 we -PRON- PRP cord-354168-omen8vvq 179 12 recommend recommend VBP cord-354168-omen8vvq 179 13 tapering taper VBG cord-354168-omen8vvq 179 14 it -PRON- PRP cord-354168-omen8vvq 179 15 down down RP cord-354168-omen8vvq 179 16 with with IN cord-354168-omen8vvq 179 17 the the DT cord-354168-omen8vvq 179 18 goal goal NN cord-354168-omen8vvq 179 19 of of IN cord-354168-omen8vvq 179 20 discontinuing discontinue VBG cord-354168-omen8vvq 179 21 it -PRON- PRP cord-354168-omen8vvq 179 22 . . . cord-354168-omen8vvq 180 1 These these DT cord-354168-omen8vvq 180 2 patients patient NNS cord-354168-omen8vvq 180 3 do do VBP cord-354168-omen8vvq 180 4 not not RB cord-354168-omen8vvq 180 5 need need VB cord-354168-omen8vvq 180 6 to to TO cord-354168-omen8vvq 180 7 be be VB cord-354168-omen8vvq 180 8 seen see VBN cord-354168-omen8vvq 180 9 in in IN cord-354168-omen8vvq 180 10 clinic clinic NN cord-354168-omen8vvq 180 11 for for IN cord-354168-omen8vvq 180 12 3 3 CD cord-354168-omen8vvq 180 13 months month NNS cord-354168-omen8vvq 180 14 . . . cord-354168-omen8vvq 181 1 Monitoring monitoring NN cord-354168-omen8vvq 181 2 should should MD cord-354168-omen8vvq 181 3 occur occur VB cord-354168-omen8vvq 181 4 in in IN cord-354168-omen8vvq 181 5 the the DT cord-354168-omen8vvq 181 6 closest close JJS cord-354168-omen8vvq 181 7 laboratory laboratory NN cord-354168-omen8vvq 181 8 and and CC cord-354168-omen8vvq 181 9 phone phone NN cord-354168-omen8vvq 181 10 visits visit NNS cord-354168-omen8vvq 181 11 may may MD cord-354168-omen8vvq 181 12 be be VB cord-354168-omen8vvq 181 13 used use VBN cord-354168-omen8vvq 181 14 for for IN cord-354168-omen8vvq 181 15 toxicity toxicity NN cord-354168-omen8vvq 181 16 checks check NNS cord-354168-omen8vvq 181 17 . . . cord-354168-omen8vvq 182 1 In in IN cord-354168-omen8vvq 182 2 many many JJ cord-354168-omen8vvq 182 3 centers center NNS cord-354168-omen8vvq 182 4 clinical clinical JJ cord-354168-omen8vvq 182 5 trials trial NNS cord-354168-omen8vvq 182 6 have have VBP cord-354168-omen8vvq 182 7 been be VBN cord-354168-omen8vvq 182 8 suspended suspend VBN cord-354168-omen8vvq 182 9 for for IN cord-354168-omen8vvq 182 10 new new JJ cord-354168-omen8vvq 182 11 patients patient NNS cord-354168-omen8vvq 182 12 because because IN cord-354168-omen8vvq 182 13 the the DT cord-354168-omen8vvq 182 14 requirements requirement NNS cord-354168-omen8vvq 182 15 for for IN cord-354168-omen8vvq 182 16 testing testing NN cord-354168-omen8vvq 182 17 lead lead NN cord-354168-omen8vvq 182 18 to to IN cord-354168-omen8vvq 182 19 frequent frequent JJ cord-354168-omen8vvq 182 20 protocol protocol NN cord-354168-omen8vvq 182 21 violations violation NNS cord-354168-omen8vvq 182 22 . . . cord-354168-omen8vvq 183 1 Some some DT cord-354168-omen8vvq 183 2 clinical clinical JJ cord-354168-omen8vvq 183 3 trials trial NNS cord-354168-omen8vvq 183 4 are be VBP cord-354168-omen8vvq 183 5 modifying modify VBG cord-354168-omen8vvq 183 6 their -PRON- PRP$ cord-354168-omen8vvq 183 7 protocols protocol NNS cord-354168-omen8vvq 183 8 , , , cord-354168-omen8vvq 183 9 allowing allow VBG cord-354168-omen8vvq 183 10 blood blood NN cord-354168-omen8vvq 183 11 draws draw VBZ cord-354168-omen8vvq 183 12 to to TO cord-354168-omen8vvq 183 13 be be VB cord-354168-omen8vvq 183 14 done do VBN cord-354168-omen8vvq 183 15 locally locally RB cord-354168-omen8vvq 183 16 , , , cord-354168-omen8vvq 183 17 telemedicine telemedicine NN cord-354168-omen8vvq 183 18 evaluation evaluation NN cord-354168-omen8vvq 183 19 , , , cord-354168-omen8vvq 183 20 and and CC cord-354168-omen8vvq 183 21 oral oral JJ cord-354168-omen8vvq 183 22 drugs drug NNS cord-354168-omen8vvq 183 23 to to TO cord-354168-omen8vvq 183 24 be be VB cord-354168-omen8vvq 183 25 shipped ship VBN cord-354168-omen8vvq 183 26 home home RB cord-354168-omen8vvq 183 27 . . . cord-354168-omen8vvq 184 1 The the DT cord-354168-omen8vvq 184 2 management management NN cord-354168-omen8vvq 184 3 of of IN cord-354168-omen8vvq 184 4 patients patient NNS cord-354168-omen8vvq 184 5 with with IN cord-354168-omen8vvq 184 6 MM MM NNP cord-354168-omen8vvq 184 7 during during IN cord-354168-omen8vvq 184 8 the the DT cord-354168-omen8vvq 184 9 current current JJ cord-354168-omen8vvq 184 10 pandemic pandemic NN cord-354168-omen8vvq 184 11 of of IN cord-354168-omen8vvq 184 12 COVID-19 COVID-19 NNP cord-354168-omen8vvq 184 13 is be VBZ cord-354168-omen8vvq 184 14 challenging challenging JJ cord-354168-omen8vvq 184 15 . . . cord-354168-omen8vvq 185 1 We -PRON- PRP cord-354168-omen8vvq 185 2 do do VBP cord-354168-omen8vvq 185 3 not not RB cord-354168-omen8vvq 185 4 recommend recommend VB cord-354168-omen8vvq 185 5 any any DT cord-354168-omen8vvq 185 6 active active JJ cord-354168-omen8vvq 185 7 therapy therapy NN cord-354168-omen8vvq 185 8 for for IN cord-354168-omen8vvq 185 9 SMM SMM NNP cord-354168-omen8vvq 185 10 patients patient NNS cord-354168-omen8vvq 185 11 , , , cord-354168-omen8vvq 185 12 standard standard JJ cord-354168-omen8vvq 185 13 or or CC cord-354168-omen8vvq 185 14 high high JJ cord-354168-omen8vvq 185 15 risk risk NN cord-354168-omen8vvq 185 16 . . . cord-354168-omen8vvq 186 1 Patients patient NNS cord-354168-omen8vvq 186 2 with with IN cord-354168-omen8vvq 186 3 active active JJ cord-354168-omen8vvq 186 4 MM MM NNP cord-354168-omen8vvq 186 5 should should MD cord-354168-omen8vvq 186 6 be be VB cord-354168-omen8vvq 186 7 risk risk NN cord-354168-omen8vvq 186 8 stratified stratify VBN cord-354168-omen8vvq 186 9 before before IN cord-354168-omen8vvq 186 10 treatment treatment NN cord-354168-omen8vvq 186 11 . . . cord-354168-omen8vvq 187 1 Screening screen VBG cord-354168-omen8vvq 187 2 for for IN cord-354168-omen8vvq 187 3 COVID-19 COVID-19 NNP cord-354168-omen8vvq 187 4 should should MD cord-354168-omen8vvq 187 5 be be VB cord-354168-omen8vvq 187 6 done do VBN cord-354168-omen8vvq 187 7 for for IN cord-354168-omen8vvq 187 8 all all DT cord-354168-omen8vvq 187 9 patients patient NNS cord-354168-omen8vvq 187 10 ( ( -LRB- cord-354168-omen8vvq 187 11 in in IN cord-354168-omen8vvq 187 12 patients patient NNS cord-354168-omen8vvq 187 13 and and CC cord-354168-omen8vvq 187 14 outpatients outpatient NNS cord-354168-omen8vvq 187 15 ) ) -RRB- cord-354168-omen8vvq 187 16 before before IN cord-354168-omen8vvq 187 17 starting start VBG cord-354168-omen8vvq 187 18 therapy therapy NN cord-354168-omen8vvq 187 19 . . . cord-354168-omen8vvq 188 1 For for IN cord-354168-omen8vvq 188 2 standard standard JJ cord-354168-omen8vvq 188 3 - - HYPH cord-354168-omen8vvq 188 4 risk risk NN cord-354168-omen8vvq 188 5 patients patient NNS cord-354168-omen8vvq 188 6 options option NNS cord-354168-omen8vvq 188 7 include include VBP cord-354168-omen8vvq 188 8 : : : cord-354168-omen8vvq 188 9 IRd IRd NNP cord-354168-omen8vvq 188 10 ( ( -LRB- cord-354168-omen8vvq 188 11 preferred prefer VBN cord-354168-omen8vvq 188 12 ) ) -RRB- cord-354168-omen8vvq 188 13 , , , cord-354168-omen8vvq 188 14 CRd CRd NNS cord-354168-omen8vvq 188 15 , , , cord-354168-omen8vvq 188 16 DRd DRd NNS cord-354168-omen8vvq 188 17 , , , cord-354168-omen8vvq 188 18 RVd rvd WDT cord-354168-omen8vvq 188 19 , , , cord-354168-omen8vvq 188 20 or or CC cord-354168-omen8vvq 188 21 CyBorD. CyBorD. NNP cord-354168-omen8vvq 189 1 For for IN cord-354168-omen8vvq 189 2 high high JJ cord-354168-omen8vvq 189 3 - - HYPH cord-354168-omen8vvq 189 4 risk risk NN cord-354168-omen8vvq 189 5 patients patient NNS cord-354168-omen8vvq 189 6 KRd KRd NNS cord-354168-omen8vvq 189 7 ( ( -LRB- cord-354168-omen8vvq 189 8 preferred prefer VBN cord-354168-omen8vvq 189 9 ) ) -RRB- cord-354168-omen8vvq 189 10 or or CC cord-354168-omen8vvq 189 11 RVd rvd WDT cord-354168-omen8vvq 189 12 are be VBP cord-354168-omen8vvq 189 13 options option NNS cord-354168-omen8vvq 189 14 . . . cord-354168-omen8vvq 190 1 We -PRON- PRP cord-354168-omen8vvq 190 2 recommend recommend VBP cord-354168-omen8vvq 190 3 decreasing decrease VBG cord-354168-omen8vvq 190 4 the the DT cord-354168-omen8vvq 190 5 dose dose NN cord-354168-omen8vvq 190 6 of of IN cord-354168-omen8vvq 190 7 dexamethasone dexamethasone NN cord-354168-omen8vvq 190 8 to to IN cord-354168-omen8vvq 190 9 20 20 CD cord-354168-omen8vvq 190 10 mg mg NNP cord-354168-omen8vvq 190 11 p.o p.o NNP cord-354168-omen8vvq 190 12 . . . cord-354168-omen8vvq 191 1 once once RB cord-354168-omen8vvq 191 2 weekly weekly RB cord-354168-omen8vvq 191 3 and and CC cord-354168-omen8vvq 191 4 the the DT cord-354168-omen8vvq 191 5 PIs pi NNS cord-354168-omen8vvq 191 6 should should MD cord-354168-omen8vvq 191 7 be be VB cord-354168-omen8vvq 191 8 given give VBN cord-354168-omen8vvq 191 9 once once RB cord-354168-omen8vvq 191 10 weekly weekly RB cord-354168-omen8vvq 191 11 with with IN cord-354168-omen8vvq 191 12 bortezomib bortezomib NNP cord-354168-omen8vvq 191 13 being be VBG cord-354168-omen8vvq 191 14 given give VBN cord-354168-omen8vvq 191 15 subcutaneously subcutaneously RB cord-354168-omen8vvq 191 16 . . . cord-354168-omen8vvq 192 1 Supportive supportive JJ cord-354168-omen8vvq 192 2 management management NN cord-354168-omen8vvq 192 3 with with IN cord-354168-omen8vvq 192 4 antibiotics antibiotic NNS cord-354168-omen8vvq 192 5 and and CC cord-354168-omen8vvq 192 6 anticoagulants anticoagulant NNS cord-354168-omen8vvq 192 7 ( ( -LRB- cord-354168-omen8vvq 192 8 as as IN cord-354168-omen8vvq 192 9 needed need VBN cord-354168-omen8vvq 192 10 ) ) -RRB- cord-354168-omen8vvq 192 11 is be VBZ cord-354168-omen8vvq 192 12 critical critical JJ cord-354168-omen8vvq 192 13 . . . cord-354168-omen8vvq 193 1 We -PRON- PRP cord-354168-omen8vvq 193 2 recommend recommend VBP cord-354168-omen8vvq 193 3 delaying delay VBG cord-354168-omen8vvq 193 4 ASCT ASCT NNP cord-354168-omen8vvq 193 5 , , , cord-354168-omen8vvq 193 6 un un NNP cord-354168-omen8vvq 193 7 - - NN cord-354168-omen8vvq 193 8 less less JJR cord-354168-omen8vvq 194 1 the the DT cord-354168-omen8vvq 194 2 patient patient NN cord-354168-omen8vvq 194 3 has have VBZ cord-354168-omen8vvq 194 4 high high JJ cord-354168-omen8vvq 194 5 - - HYPH cord-354168-omen8vvq 194 6 risk risk NN cord-354168-omen8vvq 194 7 disease disease NN cord-354168-omen8vvq 194 8 that that WDT cord-354168-omen8vvq 194 9 is be VBZ cord-354168-omen8vvq 194 10 not not RB cord-354168-omen8vvq 194 11 responding respond VBG cord-354168-omen8vvq 194 12 well well RB cord-354168-omen8vvq 194 13 , , , cord-354168-omen8vvq 194 14 or or CC cord-354168-omen8vvq 194 15 if if IN cord-354168-omen8vvq 194 16 the the DT cord-354168-omen8vvq 194 17 patient patient NN cord-354168-omen8vvq 194 18 has have VBZ cord-354168-omen8vvq 194 19 PCL PCL NNP cord-354168-omen8vvq 194 20 . . . cord-354168-omen8vvq 195 1 Testing test VBG cord-354168-omen8vvq 195 2 for for IN cord-354168-omen8vvq 195 3 COVID-19 COVID-19 NNP cord-354168-omen8vvq 195 4 should should MD cord-354168-omen8vvq 195 5 be be VB cord-354168-omen8vvq 195 6 done do VBN cord-354168-omen8vvq 195 7 before before IN cord-354168-omen8vvq 195 8 any any DT cord-354168-omen8vvq 195 9 ASCT ASCT NNP cord-354168-omen8vvq 195 10 or or CC cord-354168-omen8vvq 195 11 new new JJ cord-354168-omen8vvq 195 12 chemotherapy chemotherapy NN cord-354168-omen8vvq 195 13 regimen regimen NN cord-354168-omen8vvq 195 14 . . . cord-354168-omen8vvq 196 1 Doses dose NNS cord-354168-omen8vvq 196 2 and and CC cord-354168-omen8vvq 196 3 frequency frequency NN cord-354168-omen8vvq 196 4 of of IN cord-354168-omen8vvq 196 5 drug drug NN cord-354168-omen8vvq 196 6 administration administration NN cord-354168-omen8vvq 196 7 can can MD cord-354168-omen8vvq 196 8 be be VB cord-354168-omen8vvq 196 9 modified modify VBN cord-354168-omen8vvq 196 10 , , , cord-354168-omen8vvq 196 11 especially especially RB cord-354168-omen8vvq 196 12 in in IN cord-354168-omen8vvq 196 13 patients patient NNS cord-354168-omen8vvq 196 14 with with IN cord-354168-omen8vvq 196 15 ≥VGPR ≥VGPR NNS cord-354168-omen8vvq 196 16 that that WDT cord-354168-omen8vvq 196 17 is be VBZ cord-354168-omen8vvq 196 18 sustained sustain VBN cord-354168-omen8vvq 196 19 . . . cord-354168-omen8vvq 197 1 After after IN cord-354168-omen8vvq 197 2 10 10 CD cord-354168-omen8vvq 197 3 - - SYM cord-354168-omen8vvq 197 4 12 12 CD cord-354168-omen8vvq 197 5 cycles cycle NNS cord-354168-omen8vvq 197 6 , , , cord-354168-omen8vvq 197 7 maintenance maintenance NN cord-354168-omen8vvq 197 8 can can MD cord-354168-omen8vvq 197 9 be be VB cord-354168-omen8vvq 197 10 started start VBN cord-354168-omen8vvq 197 11 with with IN cord-354168-omen8vvq 197 12 lenalidomide lenalidomide NN cord-354168-omen8vvq 197 13 for for IN cord-354168-omen8vvq 197 14 standard standard JJ cord-354168-omen8vvq 197 15 - - HYPH cord-354168-omen8vvq 197 16 risk risk NN cord-354168-omen8vvq 197 17 patients patient NNS cord-354168-omen8vvq 197 18 and and CC cord-354168-omen8vvq 197 19 bortezomib bortezomib NNP cord-354168-omen8vvq 197 20 or or CC cord-354168-omen8vvq 197 21 ixazomib ixazomib JJ cord-354168-omen8vvq 197 22 for for IN cord-354168-omen8vvq 197 23 high high JJ cord-354168-omen8vvq 197 24 - - HYPH cord-354168-omen8vvq 197 25 risk risk NN cord-354168-omen8vvq 197 26 patients patient NNS cord-354168-omen8vvq 197 27 . . . cord-354168-omen8vvq 198 1 For for IN cord-354168-omen8vvq 198 2 relapsed relapsed JJ cord-354168-omen8vvq 198 3 patients patient NNS cord-354168-omen8vvq 198 4 , , , cord-354168-omen8vvq 198 5 daratumumab daratumumab VBN cord-354168-omen8vvq 198 6 - - HYPH cord-354168-omen8vvq 198 7 based base VBN cord-354168-omen8vvq 198 8 regimens regimen NNS cord-354168-omen8vvq 198 9 should should MD cord-354168-omen8vvq 198 10 be be VB cord-354168-omen8vvq 198 11 considered consider VBN cord-354168-omen8vvq 198 12 . . . cord-354168-omen8vvq 199 1 We -PRON- PRP cord-354168-omen8vvq 199 2 would would MD cord-354168-omen8vvq 199 3 recommend recommend VB cord-354168-omen8vvq 199 4 ASCT ASCT NNP cord-354168-omen8vvq 199 5 for for IN cord-354168-omen8vvq 199 6 patients patient NNS cord-354168-omen8vvq 199 7 with with IN cord-354168-omen8vvq 199 8 aggressive aggressive JJ cord-354168-omen8vvq 199 9 relapse relapse NN cord-354168-omen8vvq 199 10 , , , cord-354168-omen8vvq 199 11 as as RB cord-354168-omen8vvq 199 12 well well RB cord-354168-omen8vvq 199 13 for for IN cord-354168-omen8vvq 199 14 patients patient NNS cord-354168-omen8vvq 199 15 with with IN cord-354168-omen8vvq 199 16 secondary secondary JJ cord-354168-omen8vvq 199 17 PCL PCL NNP cord-354168-omen8vvq 199 18 . . . cord-354168-omen8vvq 200 1 Patients patient NNS cord-354168-omen8vvq 200 2 on on IN cord-354168-omen8vvq 200 3 maintenance maintenance NN cord-354168-omen8vvq 200 4 should should MD cord-354168-omen8vvq 200 5 continue continue VB cord-354168-omen8vvq 200 6 their -PRON- PRP$ cord-354168-omen8vvq 200 7 therapy therapy NN cord-354168-omen8vvq 200 8 . . . cord-354168-omen8vvq 201 1 In in IN cord-354168-omen8vvq 201 2 many many JJ cord-354168-omen8vvq 201 3 centers center NNS cord-354168-omen8vvq 201 4 clinical clinical JJ cord-354168-omen8vvq 201 5 trials trial NNS cord-354168-omen8vvq 201 6 have have VBP cord-354168-omen8vvq 201 7 been be VBN cord-354168-omen8vvq 201 8 suspended suspend VBN cord-354168-omen8vvq 201 9 as as IN cord-354168-omen8vvq 201 10 a a DT cord-354168-omen8vvq 201 11 result result NN cord-354168-omen8vvq 201 12 of of IN cord-354168-omen8vvq 201 13 the the DT cord-354168-omen8vvq 201 14 current current JJ cord-354168-omen8vvq 201 15 pandemic pandemic NN cord-354168-omen8vvq 201 16 with with IN cord-354168-omen8vvq 201 17 COVID-19 COVID-19 NNP cord-354168-omen8vvq 201 18 . . . cord-354168-omen8vvq 202 1 World World NNP cord-354168-omen8vvq 202 2 Health Health NNP cord-354168-omen8vvq 202 3 Organization Organization NNP cord-354168-omen8vvq 202 4 Coronavirus Coronavirus NNP cord-354168-omen8vvq 202 5 disease disease NN cord-354168-omen8vvq 203 1 ( ( -LRB- cord-354168-omen8vvq 203 2 COVID-2019 COVID-2019 NNP cord-354168-omen8vvq 203 3 ) ) -RRB- cord-354168-omen8vvq 203 4 situation situation NN cord-354168-omen8vvq 203 5 reports report VBZ cord-354168-omen8vvq 203 6 How how WRB cord-354168-omen8vvq 203 7 COVID-19 COVID-19 NNP cord-354168-omen8vvq 203 8 Outbreak Outbreak NNP cord-354168-omen8vvq 203 9 is be VBZ cord-354168-omen8vvq 203 10 impacting impact VBG cord-354168-omen8vvq 203 11 colorectal colorectal JJ cord-354168-omen8vvq 203 12 cancer cancer NN cord-354168-omen8vvq 203 13 patients patient NNS cord-354168-omen8vvq 203 14 in in IN cord-354168-omen8vvq 203 15 Italy Italy NNP cord-354168-omen8vvq 203 16 : : : cord-354168-omen8vvq 203 17 a a DT cord-354168-omen8vvq 203 18 long long JJ cord-354168-omen8vvq 203 19 shadow shadow NN cord-354168-omen8vvq 203 20 beyond beyond IN cord-354168-omen8vvq 203 21 infection infection NN cord-354168-omen8vvq 203 22 . . . cord-354168-omen8vvq 204 1 Dis Dis NNP cord-354168-omen8vvq 204 2 Colon colon NN cord-354168-omen8vvq 204 3 Rectum rectum NN cord-354168-omen8vvq 204 4 . . . cord-354168-omen8vvq 205 1 2020 2020 CD cord-354168-omen8vvq 205 2 Mar Mar NNP cord-354168-omen8vvq 205 3 ; ; : cord-354168-omen8vvq 205 4 1 1 CD cord-354168-omen8vvq 205 5 . . . cord-354168-omen8vvq 206 1 Epub Epub NNP cord-354168-omen8vvq 206 2 ahead ahead RB cord-354168-omen8vvq 206 3 of of IN cord-354168-omen8vvq 206 4 print print NN cord-354168-omen8vvq 206 5 Individualized individualized JJ cord-354168-omen8vvq 206 6 treatment treatment NN cord-354168-omen8vvq 206 7 recommendations recommendation NNS cord-354168-omen8vvq 206 8 for for IN cord-354168-omen8vvq 206 9 lung lung NN cord-354168-omen8vvq 206 10 cancer cancer NN cord-354168-omen8vvq 206 11 patients patient NNS cord-354168-omen8vvq 206 12 at at IN cord-354168-omen8vvq 206 13 different different JJ cord-354168-omen8vvq 206 14 stages stage NNS cord-354168-omen8vvq 206 15 of of IN cord-354168-omen8vvq 206 16 treatment treatment NN cord-354168-omen8vvq 206 17 during during IN cord-354168-omen8vvq 206 18 the the DT cord-354168-omen8vvq 206 19 outbreak outbreak NN cord-354168-omen8vvq 206 20 of of IN cord-354168-omen8vvq 206 21 Cancer Cancer NNP cord-354168-omen8vvq 206 22 patients patient NNS cord-354168-omen8vvq 206 23 in in IN cord-354168-omen8vvq 206 24 SARS SARS NNP cord-354168-omen8vvq 206 25 - - HYPH cord-354168-omen8vvq 206 26 CoV-2 CoV-2 NNP cord-354168-omen8vvq 206 27 infection infection NN cord-354168-omen8vvq 206 28 : : : cord-354168-omen8vvq 206 29 a a DT cord-354168-omen8vvq 206 30 nationwide nationwide JJ cord-354168-omen8vvq 206 31 analysis analysis NN cord-354168-omen8vvq 206 32 in in IN cord-354168-omen8vvq 206 33 China China NNP cord-354168-omen8vvq 206 34 . . . cord-354168-omen8vvq 207 1 Lancet Lancet NNP cord-354168-omen8vvq 207 2 Oncol Oncol NNP cord-354168-omen8vvq 207 3 Multiple multiple JJ cord-354168-omen8vvq 207 4 myeloma myeloma NN cord-354168-omen8vvq 207 5 and and CC cord-354168-omen8vvq 207 6 infections infection NNS cord-354168-omen8vvq 207 7 : : : cord-354168-omen8vvq 207 8 a a DT cord-354168-omen8vvq 207 9 population population NN cord-354168-omen8vvq 207 10 - - HYPH cord-354168-omen8vvq 207 11 based base VBN cord-354168-omen8vvq 207 12 study study NN cord-354168-omen8vvq 207 13 on on IN cord-354168-omen8vvq 207 14 9253 9253 CD cord-354168-omen8vvq 207 15 multiple multiple JJ cord-354168-omen8vvq 207 16 myeloma myeloma NN cord-354168-omen8vvq 207 17 patients patient NNS cord-354168-omen8vvq 207 18 Nadir Nadir NNP cord-354168-omen8vvq 207 19 lymphocytopenia lymphocytopenia NNP cord-354168-omen8vvq 207 20 as as IN cord-354168-omen8vvq 207 21 a a DT cord-354168-omen8vvq 207 22 risk risk NN cord-354168-omen8vvq 207 23 factor factor NN cord-354168-omen8vvq 207 24 of of IN cord-354168-omen8vvq 207 25 bloodstream bloodstream NN cord-354168-omen8vvq 207 26 infection infection NN cord-354168-omen8vvq 207 27 during during IN cord-354168-omen8vvq 207 28 molecular molecular JJ cord-354168-omen8vvq 207 29 targeting target VBG cord-354168-omen8vvq 207 30 pharmacotherapy pharmacotherapy NN cord-354168-omen8vvq 207 31 in in IN cord-354168-omen8vvq 207 32 multiple multiple JJ cord-354168-omen8vvq 207 33 myeloma myeloma NN cord-354168-omen8vvq 207 34 Pretreatment Pretreatment NNP cord-354168-omen8vvq 207 35 lymphopenia lymphopenia NNP cord-354168-omen8vvq 207 36 , , , cord-354168-omen8vvq 207 37 poor poor JJ cord-354168-omen8vvq 207 38 performance performance NN cord-354168-omen8vvq 207 39 status status NN cord-354168-omen8vvq 207 40 , , , cord-354168-omen8vvq 207 41 and and CC cord-354168-omen8vvq 207 42 early early JJ cord-354168-omen8vvq 207 43 courses course NNS cord-354168-omen8vvq 207 44 of of IN cord-354168-omen8vvq 207 45 therapy therapy NN cord-354168-omen8vvq 207 46 are be VBP cord-354168-omen8vvq 207 47 risk risk NN cord-354168-omen8vvq 207 48 factors factor NNS cord-354168-omen8vvq 207 49 for for IN cord-354168-omen8vvq 207 50 severe severe JJ cord-354168-omen8vvq 207 51 bacterial bacterial JJ cord-354168-omen8vvq 207 52 infection infection NN cord-354168-omen8vvq 207 53 in in IN cord-354168-omen8vvq 207 54 patients patient NNS cord-354168-omen8vvq 207 55 with with IN cord-354168-omen8vvq 207 56 multiple multiple JJ cord-354168-omen8vvq 207 57 myeloma myeloma NN cord-354168-omen8vvq 207 58 during during IN cord-354168-omen8vvq 207 59 treatment treatment NN cord-354168-omen8vvq 207 60 with with IN cord-354168-omen8vvq 207 61 bortezomib bortezomib NNP cord-354168-omen8vvq 207 62 - - HYPH cord-354168-omen8vvq 207 63 based base VBN cord-354168-omen8vvq 207 64 regimens regimen NNS cord-354168-omen8vvq 208 1 Lymphocytopenia Lymphocytopenia NNP cord-354168-omen8vvq 208 2 is be VBZ cord-354168-omen8vvq 208 3 associated associate VBN cord-354168-omen8vvq 208 4 with with IN cord-354168-omen8vvq 208 5 an an DT cord-354168-omen8vvq 208 6 increased increase VBN cord-354168-omen8vvq 208 7 risk risk NN cord-354168-omen8vvq 208 8 of of IN cord-354168-omen8vvq 208 9 severe severe JJ cord-354168-omen8vvq 208 10 infections infection NNS cord-354168-omen8vvq 208 11 in in IN cord-354168-omen8vvq 208 12 patients patient NNS cord-354168-omen8vvq 208 13 with with IN cord-354168-omen8vvq 208 14 multiple multiple JJ cord-354168-omen8vvq 208 15 myeloma myeloma NN cord-354168-omen8vvq 208 16 treated treat VBN cord-354168-omen8vvq 208 17 with with IN cord-354168-omen8vvq 208 18 bortezomib bortezomib NNP cord-354168-omen8vvq 208 19 - - HYPH cord-354168-omen8vvq 208 20 based base VBN cord-354168-omen8vvq 208 21 regimens regimen NNS cord-354168-omen8vvq 208 22 Immune immune JJ cord-354168-omen8vvq 208 23 parameters parameter NNS cord-354168-omen8vvq 208 24 in in IN cord-354168-omen8vvq 208 25 multiple multiple JJ cord-354168-omen8vvq 208 26 myeloma myeloma NN cord-354168-omen8vvq 208 27 patients patient NNS cord-354168-omen8vvq 208 28 : : : cord-354168-omen8vvq 208 29 influence influence NN cord-354168-omen8vvq 208 30 of of IN cord-354168-omen8vvq 208 31 treatment treatment NN cord-354168-omen8vvq 208 32 and and CC cord-354168-omen8vvq 208 33 correlation correlation NN cord-354168-omen8vvq 208 34 with with IN cord-354168-omen8vvq 208 35 opportunistic opportunistic JJ cord-354168-omen8vvq 208 36 infections infection NNS cord-354168-omen8vvq 208 37 Low low JJ cord-354168-omen8vvq 208 38 frequency frequency NN cord-354168-omen8vvq 208 39 of of IN cord-354168-omen8vvq 208 40 CD3+CD4+CD161 CD3+CD4+CD161 NNP cord-354168-omen8vvq 209 1 + + CC cord-354168-omen8vvq 209 2 T t NN cord-354168-omen8vvq 209 3 cells cell NNS cord-354168-omen8vvq 209 4 correlates correlate VBZ cord-354168-omen8vvq 209 5 with with IN cord-354168-omen8vvq 209 6 the the DT cord-354168-omen8vvq 209 7 occurrence occurrence NN cord-354168-omen8vvq 209 8 of of IN cord-354168-omen8vvq 209 9 infections infection NNS cord-354168-omen8vvq 209 10 in in IN cord-354168-omen8vvq 209 11 refractory refractory JJ cord-354168-omen8vvq 209 12 / / SYM cord-354168-omen8vvq 209 13 relapsed relapse VBD cord-354168-omen8vvq 209 14 multiple multiple JJ cord-354168-omen8vvq 209 15 myeloma myeloma NN cord-354168-omen8vvq 209 16 patients patient NNS cord-354168-omen8vvq 209 17 receiving receive VBG cord-354168-omen8vvq 209 18 lenalidomide lenalidomide JJ cord-354168-omen8vvq 209 19 plus plus CC cord-354168-omen8vvq 209 20 low low JJ cord-354168-omen8vvq 209 21 - - HYPH cord-354168-omen8vvq 209 22 dose dose NN cord-354168-omen8vvq 209 23 dexamethasone dexamethasone NN cord-354168-omen8vvq 209 24 treatment treatment NN cord-354168-omen8vvq 209 25 Infection Infection NNP cord-354168-omen8vvq 209 26 risk risk NN cord-354168-omen8vvq 209 27 with with IN cord-354168-omen8vvq 209 28 immunomodulatory immunomodulatory NNP cord-354168-omen8vvq 209 29 and and CC cord-354168-omen8vvq 209 30 proteasome proteasome JJ cord-354168-omen8vvq 209 31 inhibitor inhibitor NN cord-354168-omen8vvq 209 32 - - HYPH cord-354168-omen8vvq 209 33 based base VBN cord-354168-omen8vvq 209 34 therapies therapy NNS cord-354168-omen8vvq 209 35 across across IN cord-354168-omen8vvq 209 36 treatment treatment NN cord-354168-omen8vvq 209 37 phases phase NNS cord-354168-omen8vvq 209 38 for for IN cord-354168-omen8vvq 209 39 multiple multiple JJ cord-354168-omen8vvq 209 40 myeloma myeloma NN cord-354168-omen8vvq 209 41 : : : cord-354168-omen8vvq 209 42 a a DT cord-354168-omen8vvq 209 43 systematic systematic JJ cord-354168-omen8vvq 209 44 review review NN cord-354168-omen8vvq 209 45 and and CC cord-354168-omen8vvq 209 46 meta meta NNP cord-354168-omen8vvq 209 47 - - HYPH cord-354168-omen8vvq 209 48 analysis analysis NN cord-354168-omen8vvq 209 49 Decrease decrease NN cord-354168-omen8vvq 209 50 in in IN cord-354168-omen8vvq 209 51 CD4 CD4 NNP cord-354168-omen8vvq 209 52 + + CC cord-354168-omen8vvq 209 53 T t NN cord-354168-omen8vvq 209 54 - - HYPH cord-354168-omen8vvq 209 55 cell cell NN cord-354168-omen8vvq 209 56 counts count NNS cord-354168-omen8vvq 209 57 in in IN cord-354168-omen8vvq 209 58 patients patient NNS cord-354168-omen8vvq 209 59 with with IN cord-354168-omen8vvq 209 60 multiple multiple JJ cord-354168-omen8vvq 209 61 myeloma myeloma NN cord-354168-omen8vvq 209 62 treated treat VBN cord-354168-omen8vvq 209 63 with with IN cord-354168-omen8vvq 209 64 bortezomib bortezomib NNP cord-354168-omen8vvq 209 65 Analysis Analysis NNP cord-354168-omen8vvq 209 66 of of IN cord-354168-omen8vvq 209 67 herpes herpes NNP cord-354168-omen8vvq 209 68 zoster zoster NN cord-354168-omen8vvq 209 69 events event NNS cord-354168-omen8vvq 209 70 among among IN cord-354168-omen8vvq 209 71 bortezomib bortezomib NNP cord-354168-omen8vvq 209 72 - - HYPH cord-354168-omen8vvq 209 73 treated treat VBN cord-354168-omen8vvq 209 74 patients patient NNS cord-354168-omen8vvq 209 75 in in IN cord-354168-omen8vvq 209 76 the the DT cord-354168-omen8vvq 209 77 phase phase NN cord-354168-omen8vvq 209 78 III iii CD cord-354168-omen8vvq 209 79 APEX APEX NNP cord-354168-omen8vvq 209 80 study study NN cord-354168-omen8vvq 209 81 Levofloxacin Levofloxacin NNP cord-354168-omen8vvq 209 82 prophylaxis prophylaxis NN cord-354168-omen8vvq 209 83 in in IN cord-354168-omen8vvq 209 84 patients patient NNS cord-354168-omen8vvq 209 85 with with IN cord-354168-omen8vvq 209 86 newly newly RB cord-354168-omen8vvq 209 87 diagnosed diagnose VBN cord-354168-omen8vvq 209 88 myeloma myeloma NN cord-354168-omen8vvq 209 89 ( ( -LRB- cord-354168-omen8vvq 209 90 TEAMM TEAMM NNP cord-354168-omen8vvq 209 91 ) ) -RRB- cord-354168-omen8vvq 209 92 : : : cord-354168-omen8vvq 209 93 a a DT cord-354168-omen8vvq 209 94 multicentre multicentre NN cord-354168-omen8vvq 209 95 , , , cord-354168-omen8vvq 209 96 double double JJ cord-354168-omen8vvq 209 97 - - HYPH cord-354168-omen8vvq 209 98 blind blind JJ cord-354168-omen8vvq 209 99 , , , cord-354168-omen8vvq 209 100 placebo placebo NN cord-354168-omen8vvq 209 101 - - HYPH cord-354168-omen8vvq 209 102 controlled control VBN cord-354168-omen8vvq 209 103 , , , cord-354168-omen8vvq 209 104 randomised randomised JJ cord-354168-omen8vvq 209 105 , , , cord-354168-omen8vvq 209 106 phase phase NN cord-354168-omen8vvq 209 107 3 3 CD cord-354168-omen8vvq 209 108 trial trial NN cord-354168-omen8vvq 209 109 Clinical clinical JJ cord-354168-omen8vvq 209 110 features feature NNS cord-354168-omen8vvq 209 111 of of IN cord-354168-omen8vvq 209 112 patients patient NNS cord-354168-omen8vvq 209 113 infected infect VBN cord-354168-omen8vvq 209 114 with with IN cord-354168-omen8vvq 209 115 2019 2019 CD cord-354168-omen8vvq 209 116 novel novel JJ cord-354168-omen8vvq 209 117 coronavirus coronavirus NN cord-354168-omen8vvq 209 118 in in IN cord-354168-omen8vvq 209 119 Wuhan Wuhan NNP cord-354168-omen8vvq 209 120 Risk Risk NNP cord-354168-omen8vvq 209 121 stratification stratification NN cord-354168-omen8vvq 209 122 of of IN cord-354168-omen8vvq 209 123 smoldering smolder VBG cord-354168-omen8vvq 209 124 multiple multiple JJ cord-354168-omen8vvq 209 125 myeloma myeloma NN cord-354168-omen8vvq 209 126 incorporating incorporate VBG cord-354168-omen8vvq 209 127 revised revise VBN cord-354168-omen8vvq 209 128 IMWG IMWG NNP cord-354168-omen8vvq 209 129 diagnostic diagnostic JJ cord-354168-omen8vvq 209 130 criteria criterion NNS cord-354168-omen8vvq 209 131 Lenalidomide Lenalidomide NNP cord-354168-omen8vvq 209 132 plus plus CC cord-354168-omen8vvq 209 133 dexamethasone dexamethasone NN cord-354168-omen8vvq 209 134 for for IN cord-354168-omen8vvq 209 135 high high JJ cord-354168-omen8vvq 209 136 - - HYPH cord-354168-omen8vvq 209 137 risk risk NN cord-354168-omen8vvq 209 138 smoldering smolder VBG cord-354168-omen8vvq 209 139 multiple multiple JJ cord-354168-omen8vvq 209 140 myeloma myeloma NN cord-354168-omen8vvq 210 1 Randomized randomized JJ cord-354168-omen8vvq 210 2 trial trial NN cord-354168-omen8vvq 210 3 of of IN cord-354168-omen8vvq 210 4 lenalidomide lenalidomide NN cord-354168-omen8vvq 210 5 versus versus IN cord-354168-omen8vvq 210 6 observation observation NN cord-354168-omen8vvq 210 7 in in IN cord-354168-omen8vvq 210 8 smoldering smolder VBG cord-354168-omen8vvq 210 9 multiple multiple JJ cord-354168-omen8vvq 210 10 myeloma myeloma NN cord-354168-omen8vvq 210 11 Revised revise VBN cord-354168-omen8vvq 210 12 international international JJ cord-354168-omen8vvq 210 13 staging staging NN cord-354168-omen8vvq 210 14 system system NN cord-354168-omen8vvq 210 15 for for IN cord-354168-omen8vvq 210 16 multiple multiple JJ cord-354168-omen8vvq 210 17 myeloma myeloma NN cord-354168-omen8vvq 210 18 : : : cord-354168-omen8vvq 210 19 a a DT cord-354168-omen8vvq 210 20 report report NN cord-354168-omen8vvq 210 21 from from IN cord-354168-omen8vvq 210 22 International International NNP cord-354168-omen8vvq 210 23 Myeloma Myeloma NNP cord-354168-omen8vvq 210 24 Working Working NNP cord-354168-omen8vvq 210 25 Group Group NNP cord-354168-omen8vvq 210 26 get-your-household-ready-for-COVID-19.html?CDC_AA get-your-household-ready-for-COVID-19.html?CDC_AA NNP cord-354168-omen8vvq 210 27 _ _ NNP cord-354168-omen8vvq 210 28 r r NN cord-354168-omen8vvq 210 29 e e NN cord-354168-omen8vvq 210 30 f f NN cord-354168-omen8vvq 210 31 V V NNP cord-354168-omen8vvq 210 32 a a DT cord-354168-omen8vvq 211 1 l l NN cord-354168-omen8vvq 211 2 = = SYM cord-354168-omen8vvq 211 3 h h NN cord-354168-omen8vvq 211 4 t t NN cord-354168-omen8vvq 211 5 t t NN cord-354168-omen8vvq 211 6 p p NN cord-354168-omen8vvq 211 7 s s NN cord-354168-omen8vvq 211 8 % % NN cord-354168-omen8vvq 211 9 3 3 CD cord-354168-omen8vvq 211 10 A a DT cord-354168-omen8vvq 211 11 % % NN cord-354168-omen8vvq 211 12 2 2 CD cord-354168-omen8vvq 211 13 F f NN cord-354168-omen8vvq 211 14 % % NN cord-354168-omen8vvq 211 15 2 2 CD cord-354168-omen8vvq 211 16 F F NNP cord-354168-omen8vvq 211 17 w w NNP cord-354168-omen8vvq 211 18 w w NNP cord-354168-omen8vvq 211 19 w w NNP cord-354168-omen8vvq 211 20 Suicide Suicide NNP cord-354168-omen8vvq 211 21 Prevention Prevention NNP cord-354168-omen8vvq 211 22 Lifeline Lifeline NNP cord-354168-omen8vvq 211 23 Emotional emotional JJ cord-354168-omen8vvq 211 24 wellbeing wellbeing NN cord-354168-omen8vvq 211 25 during during IN cord-354168-omen8vvq 211 26 the the DT cord-354168-omen8vvq 211 27 COVID-19 covid-19 JJ cord-354168-omen8vvq 211 28 outbreak outbreak NN cord-354168-omen8vvq 211 29 lenalidomide lenalidomide NN cord-354168-omen8vvq 211 30 , , , cord-354168-omen8vvq 211 31 and and CC cord-354168-omen8vvq 211 32 dexamethasone dexamethasone NN cord-354168-omen8vvq 211 33 in in IN cord-354168-omen8vvq 211 34 patients patient NNS cord-354168-omen8vvq 211 35 with with IN cord-354168-omen8vvq 211 36 newly newly RB cord-354168-omen8vvq 211 37 diagnosed diagnose VBN cord-354168-omen8vvq 211 38 multiple multiple JJ cord-354168-omen8vvq 211 39 myeloma myeloma NN cord-354168-omen8vvq 211 40 : : : cord-354168-omen8vvq 211 41 long long JJ cord-354168-omen8vvq 211 42 - - HYPH cord-354168-omen8vvq 211 43 term term NN cord-354168-omen8vvq 211 44 follow follow NN cord-354168-omen8vvq 211 45 - - HYPH cord-354168-omen8vvq 211 46 up up NN cord-354168-omen8vvq 211 47 including include VBG cord-354168-omen8vvq 211 48 ixazomib ixazomib JJ cord-354168-omen8vvq 211 49 maintenance maintenance NN cord-354168-omen8vvq 211 50 cyclophosphamide cyclophosphamide RB cord-354168-omen8vvq 211 51 and and CC cord-354168-omen8vvq 211 52 dexamethasone dexamethasone NN cord-354168-omen8vvq 211 53 ( ( -LRB- cord-354168-omen8vvq 211 54 CRd CRd NNP cord-354168-omen8vvq 211 55 ) ) -RRB- cord-354168-omen8vvq 211 56 for for IN cord-354168-omen8vvq 211 57 newly newly RB cord-354168-omen8vvq 211 58 diagnosed diagnose VBN cord-354168-omen8vvq 211 59 multiple multiple JJ cord-354168-omen8vvq 211 60 myeloma myeloma NN cord-354168-omen8vvq 211 61 : : : cord-354168-omen8vvq 211 62 results result NNS cord-354168-omen8vvq 211 63 from from IN cord-354168-omen8vvq 211 64 a a DT cord-354168-omen8vvq 211 65 phase phase NN cord-354168-omen8vvq 211 66 2 2 CD cord-354168-omen8vvq 211 67 trial trial NN cord-354168-omen8vvq 211 68 MAIA MAIA NNP cord-354168-omen8vvq 211 69 Trial Trial NNP cord-354168-omen8vvq 211 70 Investigators Investigators NNPS cord-354168-omen8vvq 211 71 . . . cord-354168-omen8vvq 212 1 Daratumumab Daratumumab NNP cord-354168-omen8vvq 212 2 plus plus CC cord-354168-omen8vvq 212 3 lenalidomide lenalidomide NN cord-354168-omen8vvq 212 4 and and CC cord-354168-omen8vvq 212 5 dexamethasone dexamethasone NN cord-354168-omen8vvq 212 6 for for IN cord-354168-omen8vvq 212 7 untreated untreated JJ cord-354168-omen8vvq 212 8 myeloma myeloma NN cord-354168-omen8vvq 212 9 High high JJ cord-354168-omen8vvq 212 10 - - HYPH cord-354168-omen8vvq 212 11 dose dose NN cord-354168-omen8vvq 212 12 therapy therapy NN cord-354168-omen8vvq 212 13 and and CC cord-354168-omen8vvq 212 14 autologous autologous JJ cord-354168-omen8vvq 212 15 peripheral peripheral JJ cord-354168-omen8vvq 212 16 blood blood NN cord-354168-omen8vvq 212 17 stem stem NN cord-354168-omen8vvq 212 18 cell cell NN cord-354168-omen8vvq 212 19 transplantation transplantation NN cord-354168-omen8vvq 212 20 in in IN cord-354168-omen8vvq 212 21 multiple multiple JJ cord-354168-omen8vvq 212 22 myeloma myeloma NN cord-354168-omen8vvq 212 23 : : : cord-354168-omen8vvq 212 24 upfront upfront NN cord-354168-omen8vvq 212 25 or or CC cord-354168-omen8vvq 212 26 rescue rescue NN cord-354168-omen8vvq 212 27 treatment treatment NN cord-354168-omen8vvq 212 28 ? ? . cord-354168-omen8vvq 213 1 Results result NNS cord-354168-omen8vvq 213 2 of of IN cord-354168-omen8vvq 213 3 a a DT cord-354168-omen8vvq 213 4 multicenter multicenter JJ cord-354168-omen8vvq 213 5 sequential sequential JJ cord-354168-omen8vvq 213 6 randomized randomized JJ cord-354168-omen8vvq 213 7 clinical clinical JJ cord-354168-omen8vvq 213 8 trial trial NN cord-354168-omen8vvq 213 9 IFM IFM NNP cord-354168-omen8vvq 213 10 2009 2009 CD cord-354168-omen8vvq 213 11 Study Study NNP cord-354168-omen8vvq 213 12 . . . cord-354168-omen8vvq 214 1 Lenalidomide Lenalidomide NNP cord-354168-omen8vvq 214 2 , , , cord-354168-omen8vvq 214 3 Bortezomib Bortezomib NNP cord-354168-omen8vvq 214 4 , , , cord-354168-omen8vvq 214 5 and and CC cord-354168-omen8vvq 214 6 Dexamethasone Dexamethasone NNP cord-354168-omen8vvq 214 7 with with IN cord-354168-omen8vvq 214 8 Transplantation transplantation NN cord-354168-omen8vvq 214 9 for for IN cord-354168-omen8vvq 214 10 Myeloma Myeloma NNP cord-354168-omen8vvq 214 11 Early early RB cord-354168-omen8vvq 214 12 versus versus IN cord-354168-omen8vvq 214 13 delayed delay VBN cord-354168-omen8vvq 214 14 autologous autologous JJ cord-354168-omen8vvq 214 15 transplantation transplantation NN cord-354168-omen8vvq 214 16 after after IN cord-354168-omen8vvq 214 17 immunomodulatory immunomodulatory JJ cord-354168-omen8vvq 214 18 agents agent NNS cord-354168-omen8vvq 214 19 - - HYPH cord-354168-omen8vvq 214 20 based base VBN cord-354168-omen8vvq 214 21 induction induction NN cord-354168-omen8vvq 214 22 therapy therapy NN cord-354168-omen8vvq 214 23 in in IN cord-354168-omen8vvq 214 24 patients patient NNS cord-354168-omen8vvq 214 25 with with IN cord-354168-omen8vvq 214 26 newly newly RB cord-354168-omen8vvq 214 27 diagnosed diagnose VBN cord-354168-omen8vvq 214 28 multiple multiple JJ cord-354168-omen8vvq 214 29 myeloma myeloma NN cord-354168-omen8vvq 214 30 Early early RB cord-354168-omen8vvq 214 31 versus versus IN cord-354168-omen8vvq 214 32 delayed delay VBN cord-354168-omen8vvq 214 33 autologous autologous JJ cord-354168-omen8vvq 214 34 stem stem NN cord-354168-omen8vvq 214 35 cell cell NN cord-354168-omen8vvq 214 36 transplantation transplantation NN cord-354168-omen8vvq 214 37 and and CC cord-354168-omen8vvq 214 38 interferon interferon NN cord-354168-omen8vvq 214 39 maintenance maintenance NN cord-354168-omen8vvq 214 40 in in IN cord-354168-omen8vvq 214 41 multiple multiple JJ cord-354168-omen8vvq 214 42 myeloma myeloma NN cord-354168-omen8vvq 214 43 : : : cord-354168-omen8vvq 214 44 single single JJ cord-354168-omen8vvq 214 45 - - HYPH cord-354168-omen8vvq 214 46 center center NN cord-354168-omen8vvq 214 47 experience experience NN cord-354168-omen8vvq 214 48 of of IN cord-354168-omen8vvq 214 49 18 18 CD cord-354168-omen8vvq 214 50 Years year NNS cord-354168-omen8vvq 215 1 Early early RB cord-354168-omen8vvq 215 2 versus versus IN cord-354168-omen8vvq 215 3 delayed delay VBN cord-354168-omen8vvq 215 4 autologous autologous JJ cord-354168-omen8vvq 215 5 stem stem NN cord-354168-omen8vvq 215 6 cell cell NN cord-354168-omen8vvq 215 7 transplant transplant NN cord-354168-omen8vvq 215 8 in in IN cord-354168-omen8vvq 215 9 patients patient NNS cord-354168-omen8vvq 215 10 receiving receive VBG cord-354168-omen8vvq 215 11 novel novel JJ cord-354168-omen8vvq 215 12 therapies therapy NNS cord-354168-omen8vvq 215 13 for for IN cord-354168-omen8vvq 215 14 multiple multiple JJ cord-354168-omen8vvq 215 15 myeloma myeloma NN cord-354168-omen8vvq 215 16 Impact impact NN cord-354168-omen8vvq 215 17 of of IN cord-354168-omen8vvq 215 18 duration duration NN cord-354168-omen8vvq 215 19 of of IN cord-354168-omen8vvq 215 20 induction induction NN cord-354168-omen8vvq 215 21 therapy therapy NN cord-354168-omen8vvq 215 22 on on IN cord-354168-omen8vvq 215 23 survival survival NN cord-354168-omen8vvq 215 24 in in IN cord-354168-omen8vvq 215 25 newly newly RB cord-354168-omen8vvq 215 26 diagnosed diagnose VBN cord-354168-omen8vvq 215 27 multiple multiple JJ cord-354168-omen8vvq 215 28 myeloma myeloma NN cord-354168-omen8vvq 215 29 patients patient NNS cord-354168-omen8vvq 215 30 undergoing undergo VBG cord-354168-omen8vvq 215 31 upfront upfront JJ cord-354168-omen8vvq 215 32 autologous autologous JJ cord-354168-omen8vvq 215 33 stem stem NN cord-354168-omen8vvq 215 34 cell cell NN cord-354168-omen8vvq 215 35 transplantation transplantation NN cord-354168-omen8vvq 215 36 Revised revise VBD cord-354168-omen8vvq 215 37 diagnostic diagnostic JJ cord-354168-omen8vvq 215 38 criteria criterion NNS cord-354168-omen8vvq 215 39 for for IN cord-354168-omen8vvq 215 40 plasma plasma NN cord-354168-omen8vvq 215 41 cell cell NN cord-354168-omen8vvq 215 42 leukemia leukemia NN cord-354168-omen8vvq 215 43 : : : cord-354168-omen8vvq 216 1 results result NNS cord-354168-omen8vvq 216 2 of of IN cord-354168-omen8vvq 216 3 a a DT cord-354168-omen8vvq 216 4 Mayo Mayo NNP cord-354168-omen8vvq 216 5 Clinic Clinic NNP cord-354168-omen8vvq 216 6 study study NN cord-354168-omen8vvq 216 7 with with IN cord-354168-omen8vvq 216 8 comparison comparison NN cord-354168-omen8vvq 216 9 of of IN cord-354168-omen8vvq 216 10 outcomes outcome NNS cord-354168-omen8vvq 216 11 to to IN cord-354168-omen8vvq 216 12 multiple multiple JJ cord-354168-omen8vvq 216 13 myeloma myeloma NN cord-354168-omen8vvq 216 14 Impact Impact NNP cord-354168-omen8vvq 216 15 of of IN cord-354168-omen8vvq 216 16 lenalidomide lenalidomide JJ cord-354168-omen8vvq 216 17 therapy therapy NN cord-354168-omen8vvq 216 18 on on IN cord-354168-omen8vvq 216 19 stem stem NN cord-354168-omen8vvq 216 20 cell cell NN cord-354168-omen8vvq 216 21 mobilization mobilization NN cord-354168-omen8vvq 216 22 and and CC cord-354168-omen8vvq 216 23 engraftment engraftment NN cord-354168-omen8vvq 216 24 post post JJ cord-354168-omen8vvq 216 25 - - JJ cord-354168-omen8vvq 216 26 peripheral peripheral JJ cord-354168-omen8vvq 216 27 blood blood NN cord-354168-omen8vvq 216 28 stem stem NN cord-354168-omen8vvq 216 29 cell cell NN cord-354168-omen8vvq 216 30 transplantation transplantation NN cord-354168-omen8vvq 216 31 in in IN cord-354168-omen8vvq 216 32 patients patient NNS cord-354168-omen8vvq 216 33 with with IN cord-354168-omen8vvq 216 34 newly newly RB cord-354168-omen8vvq 216 35 diagnosed diagnose VBN cord-354168-omen8vvq 216 36 myeloma myeloma NN cord-354168-omen8vvq 216 37 Advances advance NNS cord-354168-omen8vvq 216 38 in in IN cord-354168-omen8vvq 216 39 the the DT cord-354168-omen8vvq 216 40 research research NN cord-354168-omen8vvq 216 41 of of IN cord-354168-omen8vvq 216 42 cytokine cytokine NN cord-354168-omen8vvq 216 43 storm storm NN cord-354168-omen8vvq 216 44 mechanism mechanism NN cord-354168-omen8vvq 216 45 induced induce VBN cord-354168-omen8vvq 216 46 by by IN cord-354168-omen8vvq 216 47 Corona Corona NNP cord-354168-omen8vvq 216 48 Virus Virus NNP cord-354168-omen8vvq 216 49 Disease Disease NNP cord-354168-omen8vvq 216 50 2019 2019 CD cord-354168-omen8vvq 216 51 and and CC cord-354168-omen8vvq 216 52 the the DT cord-354168-omen8vvq 216 53 corresponding correspond VBG cord-354168-omen8vvq 216 54 immunotherapies immunotherapy NNS cord-354168-omen8vvq 216 55 ] ] -RRB- cord-354168-omen8vvq 216 56 . . . cord-354168-omen8vvq 217 1 Zhonghua Zhonghua NNP cord-354168-omen8vvq 217 2 Shao Shao NNP cord-354168-omen8vvq 217 3 Shang Shang NNP cord-354168-omen8vvq 217 4 Za Za NNP cord-354168-omen8vvq 217 5 Zhi Zhi NNP cord-354168-omen8vvq 217 6 Pathological pathological JJ cord-354168-omen8vvq 217 7 findings finding NNS cord-354168-omen8vvq 217 8 of of IN cord-354168-omen8vvq 217 9 CO co NN cord-354168-omen8vvq 217 10 - - HYPH cord-354168-omen8vvq 217 11 VID-19 VID-19 NNP cord-354168-omen8vvq 217 12 associated associate VBN cord-354168-omen8vvq 217 13 with with IN cord-354168-omen8vvq 217 14 acute acute JJ cord-354168-omen8vvq 217 15 respiratory respiratory JJ cord-354168-omen8vvq 217 16 distress distress NN cord-354168-omen8vvq 217 17 syndrome syndrome NN cord-354168-omen8vvq 217 18 Treatment Treatment NNP cord-354168-omen8vvq 217 19 guidelines guideline NNS cord-354168-omen8vvq 217 20 : : : cord-354168-omen8vvq 217 21 multiple multiple JJ cord-354168-omen8vvq 217 22 myeloma myeloma NN cord-354168-omen8vvq 217 23 Genetic genetic JJ cord-354168-omen8vvq 217 24 aberrations aberration NNS cord-354168-omen8vvq 217 25 and and CC cord-354168-omen8vvq 217 26 survival survival NN cord-354168-omen8vvq 217 27 in in IN cord-354168-omen8vvq 217 28 plasma plasma NN cord-354168-omen8vvq 217 29 cell cell NN cord-354168-omen8vvq 217 30 leukemia leukemia NN cord-354168-omen8vvq 218 1 The the DT cord-354168-omen8vvq 218 2 authors author NNS cord-354168-omen8vvq 218 3 have have VBP cord-354168-omen8vvq 218 4 no no DT cord-354168-omen8vvq 218 5 conflicts conflict NNS cord-354168-omen8vvq 218 6 of of IN cord-354168-omen8vvq 218 7 interest interest NN cord-354168-omen8vvq 218 8 to to TO cord-354168-omen8vvq 218 9 declare declare VB cord-354168-omen8vvq 218 10 related relate VBN cord-354168-omen8vvq 218 11 to to IN cord-354168-omen8vvq 218 12 this this DT cord-354168-omen8vvq 218 13 paper paper NN cord-354168-omen8vvq 218 14 . . . cord-354168-omen8vvq 219 1 A a DT cord-354168-omen8vvq 219 2 _SP cord-354168-omen8vvq 220 1 The the DT cord-354168-omen8vvq 220 2 authors author NNS cord-354168-omen8vvq 220 3 have have VBP cord-354168-omen8vvq 220 4 no no DT cord-354168-omen8vvq 220 5 funding funding NN cord-354168-omen8vvq 220 6 sources source NNS cord-354168-omen8vvq 220 7 to to TO cord-354168-omen8vvq 220 8 declare declare VB cord-354168-omen8vvq 220 9 . . . cord-354168-omen8vvq 220 10 _SP