id	sid	tid	token	lemma	pos
cord-350992-l6l24pco	1	1	key	key	JJ
cord-350992-l6l24pco	1	2	:	:	:
cord-350992-l6l24pco	1	3	cord-350992-l6l24pco	cord-350992-l6l24pco	NNP
cord-350992-l6l24pco	1	4	authors	author	NNS
cord-350992-l6l24pco	1	5	:	:	:
cord-350992-l6l24pco	1	6	Roldan	Roldan	NNP
cord-350992-l6l24pco	1	7	,	,	,
cord-350992-l6l24pco	1	8	Eugenia	Eugenia	NNP
cord-350992-l6l24pco	1	9	Quiros	Quiros	NNP
cord-350992-l6l24pco	1	10	;	;	:
cord-350992-l6l24pco	1	11	Biasiotto	Biasiotto	NNP
cord-350992-l6l24pco	1	12	,	,	,
cord-350992-l6l24pco	1	13	Giorgio	Giorgio	NNP
cord-350992-l6l24pco	1	14	;	;	:
cord-350992-l6l24pco	1	15	Magro	Magro	NNP
cord-350992-l6l24pco	1	16	,	,	,
cord-350992-l6l24pco	1	17	Paola	Paola	NNP
cord-350992-l6l24pco	1	18	;	;	:
cord-350992-l6l24pco	1	19	Zanella	Zanella	NNP
cord-350992-l6l24pco	1	20	,	,	,
cord-350992-l6l24pco	1	21	Isabella	Isabella	NNP
cord-350992-l6l24pco	2	1	title	title	NN
cord-350992-l6l24pco	2	2	:	:	:
cord-350992-l6l24pco	3	1	The	the	DT
cord-350992-l6l24pco	3	2	possible	possible	JJ
cord-350992-l6l24pco	3	3	mechanisms	mechanism	NNS
cord-350992-l6l24pco	3	4	of	of	IN
cord-350992-l6l24pco	3	5	action	action	NN
cord-350992-l6l24pco	3	6	of	of	IN
cord-350992-l6l24pco	3	7	4-aminoquinolines	4-aminoquinolines	CD
cord-350992-l6l24pco	3	8	(	(	-LRB-
cord-350992-l6l24pco	3	9	chloroquine	chloroquine	NNP
cord-350992-l6l24pco	3	10	/	/	SYM
cord-350992-l6l24pco	3	11	hydroxychloroquine	hydroxychloroquine	NNP
cord-350992-l6l24pco	3	12	)	)	-RRB-
cord-350992-l6l24pco	3	13	against	against	IN
cord-350992-l6l24pco	3	14	Sars	Sars	NNP
cord-350992-l6l24pco	3	15	-	-	HYPH
cord-350992-l6l24pco	3	16	Cov-2	Cov-2	NNP
cord-350992-l6l24pco	3	17	infection	infection	NN
cord-350992-l6l24pco	3	18	(	(	-LRB-
cord-350992-l6l24pco	3	19	COVID-19	covid-19	VB
cord-350992-l6l24pco	3	20	)	)	-RRB-
cord-350992-l6l24pco	3	21	:	:	:
cord-350992-l6l24pco	3	22	A	a	DT
cord-350992-l6l24pco	3	23	role	role	NN
cord-350992-l6l24pco	3	24	for	for	IN
cord-350992-l6l24pco	3	25	iron	iron	NN
cord-350992-l6l24pco	3	26	homeostasis	homeostasis	NN
cord-350992-l6l24pco	3	27	?	?	.
cord-350992-l6l24pco	4	1	date	date	NN
cord-350992-l6l24pco	4	2	:	:	:
cord-350992-l6l24pco	4	3	2020	2020	CD
cord-350992-l6l24pco	4	4	-	-	HYPH
cord-350992-l6l24pco	4	5	05	05	CD
cord-350992-l6l24pco	4	6	-	-	SYM
cord-350992-l6l24pco	4	7	13	13	CD
cord-350992-l6l24pco	4	8	journal	journal	NN
cord-350992-l6l24pco	4	9	:	:	:
cord-350992-l6l24pco	5	1	Pharmacol	Pharmacol	NNP
cord-350992-l6l24pco	5	2	Res	Res	NNP
cord-350992-l6l24pco	5	3	DOI	DOI	NNP
cord-350992-l6l24pco	5	4	:	:	:
cord-350992-l6l24pco	5	5	10.1016	10.1016	CD
cord-350992-l6l24pco	5	6	/	/	SYM
cord-350992-l6l24pco	5	7	j.phrs.2020.104904	j.phrs.2020.104904	NN
cord-350992-l6l24pco	5	8	sha	sha	NNP
cord-350992-l6l24pco	5	9	:	:	:
cord-350992-l6l24pco	5	10	e013e370b78159957ea87f6f1cd22691d32f784b	e013e370b78159957ea87f6f1cd22691d32f784b	NNP
cord-350992-l6l24pco	5	11	doc_id	doc_id	NNPS
cord-350992-l6l24pco	5	12	:	:	:
cord-350992-l6l24pco	5	13	350992	350992	CD
cord-350992-l6l24pco	5	14	cord_uid	cord_uid	FW
cord-350992-l6l24pco	5	15	:	:	:
cord-350992-l6l24pco	5	16	l6l24pco	l6l24pco	NNP
cord-350992-l6l24pco	5	17	The	the	DT
cord-350992-l6l24pco	5	18	anti	anti	JJ
cord-350992-l6l24pco	5	19	-	-	JJ
cord-350992-l6l24pco	5	20	malarial	malarial	JJ
cord-350992-l6l24pco	5	21	drugs	drug	NNS
cord-350992-l6l24pco	5	22	chloroquine	chloroquine	NN
cord-350992-l6l24pco	5	23	(	(	-LRB-
cord-350992-l6l24pco	5	24	CQ	CQ	NNP
cord-350992-l6l24pco	5	25	)	)	-RRB-
cord-350992-l6l24pco	5	26	and	and	CC
cord-350992-l6l24pco	5	27	primarily	primarily	RB
cord-350992-l6l24pco	5	28	the	the	DT
cord-350992-l6l24pco	5	29	less	less	RBR
cord-350992-l6l24pco	5	30	toxic	toxic	JJ
cord-350992-l6l24pco	5	31	hydroxychloroquine	hydroxychloroquine	NN
cord-350992-l6l24pco	5	32	(	(	-LRB-
cord-350992-l6l24pco	5	33	HCQ	HCQ	NNP
cord-350992-l6l24pco	5	34	)	)	-RRB-
cord-350992-l6l24pco	5	35	are	be	VBP
cord-350992-l6l24pco	5	36	currently	currently	RB
cord-350992-l6l24pco	5	37	used	use	VBN
cord-350992-l6l24pco	5	38	to	to	TO
cord-350992-l6l24pco	5	39	treat	treat	VB
cord-350992-l6l24pco	5	40	autoimmune	autoimmune	JJ
cord-350992-l6l24pco	5	41	diseases	disease	NNS
cord-350992-l6l24pco	5	42	for	for	IN
cord-350992-l6l24pco	5	43	their	-PRON-	PRP$
cord-350992-l6l24pco	5	44	immunomodulatory	immunomodulatory	JJ
cord-350992-l6l24pco	5	45	and	and	CC
cord-350992-l6l24pco	5	46	anti	anti	JJ
cord-350992-l6l24pco	5	47	-	-	JJ
cord-350992-l6l24pco	5	48	thrombotic	thrombotic	JJ
cord-350992-l6l24pco	5	49	properties	property	NNS
cord-350992-l6l24pco	5	50	.	.	.
cord-350992-l6l24pco	6	1	They	-PRON-	PRP
cord-350992-l6l24pco	6	2	have	have	VBP
cord-350992-l6l24pco	6	3	also	also	RB
cord-350992-l6l24pco	6	4	been	be	VBN
cord-350992-l6l24pco	6	5	proposed	propose	VBN
cord-350992-l6l24pco	6	6	for	for	IN
cord-350992-l6l24pco	6	7	the	the	DT
cord-350992-l6l24pco	6	8	treatment	treatment	NN
cord-350992-l6l24pco	6	9	of	of	IN
cord-350992-l6l24pco	6	10	several	several	JJ
cord-350992-l6l24pco	6	11	viral	viral	JJ
cord-350992-l6l24pco	6	12	infections	infection	NNS
cord-350992-l6l24pco	6	13	,	,	,
cord-350992-l6l24pco	6	14	due	due	IN
cord-350992-l6l24pco	6	15	to	to	IN
cord-350992-l6l24pco	6	16	their	-PRON-	PRP$
cord-350992-l6l24pco	6	17	anti	anti	JJ
cord-350992-l6l24pco	6	18	-	-	JJ
cord-350992-l6l24pco	6	19	viral	viral	JJ
cord-350992-l6l24pco	6	20	effects	effect	NNS
cord-350992-l6l24pco	6	21	in	in	IN
cord-350992-l6l24pco	6	22	cell	cell	NN
cord-350992-l6l24pco	6	23	cultures	culture	NNS
cord-350992-l6l24pco	6	24	and	and	CC
cord-350992-l6l24pco	6	25	animal	animal	NN
cord-350992-l6l24pco	6	26	models	model	NNS
cord-350992-l6l24pco	6	27	,	,	,
cord-350992-l6l24pco	6	28	and	and	CC
cord-350992-l6l24pco	6	29	,	,	,
cord-350992-l6l24pco	6	30	currently	currently	RB
cord-350992-l6l24pco	6	31	,	,	,
cord-350992-l6l24pco	6	32	for	for	IN
cord-350992-l6l24pco	6	33	the	the	DT
cord-350992-l6l24pco	6	34	treatment	treatment	NN
cord-350992-l6l24pco	6	35	of	of	IN
cord-350992-l6l24pco	6	36	coronavirus	coronavirus	NN
cord-350992-l6l24pco	6	37	disease	disease	NN
cord-350992-l6l24pco	6	38	2019	2019	CD
cord-350992-l6l24pco	6	39	(	(	-LRB-
cord-350992-l6l24pco	6	40	COVID-19	COVID-19	NNP
cord-350992-l6l24pco	6	41	)	)	-RRB-
cord-350992-l6l24pco	6	42	,	,	,
cord-350992-l6l24pco	6	43	the	the	DT
cord-350992-l6l24pco	6	44	pandemic	pandemic	NN
cord-350992-l6l24pco	6	45	severe	severe	JJ
cord-350992-l6l24pco	6	46	acute	acute	JJ
cord-350992-l6l24pco	6	47	respiratory	respiratory	JJ
cord-350992-l6l24pco	6	48	syndrome	syndrome	NN
cord-350992-l6l24pco	6	49	caused	cause	VBN
cord-350992-l6l24pco	6	50	by	by	IN
cord-350992-l6l24pco	6	51	coronavirus	coronavirus	NN
cord-350992-l6l24pco	6	52	2	2	CD
cord-350992-l6l24pco	6	53	(	(	-LRB-
cord-350992-l6l24pco	6	54	Sars	Sars	NNP
cord-350992-l6l24pco	6	55	-	-	HYPH
cord-350992-l6l24pco	6	56	Cov-2	Cov-2	NNP
cord-350992-l6l24pco	6	57	)	)	-RRB-
cord-350992-l6l24pco	6	58	infection	infection	NN
cord-350992-l6l24pco	6	59	that	that	WDT
cord-350992-l6l24pco	6	60	is	be	VBZ
cord-350992-l6l24pco	6	61	spreading	spread	VBG
cord-350992-l6l24pco	6	62	all	all	RB
cord-350992-l6l24pco	6	63	over	over	IN
cord-350992-l6l24pco	6	64	the	the	DT
cord-350992-l6l24pco	6	65	world	world	NN
cord-350992-l6l24pco	6	66	.	.	.
cord-350992-l6l24pco	7	1	Although	although	IN
cord-350992-l6l24pco	7	2	in	in	IN
cord-350992-l6l24pco	7	3	some	some	DT
cord-350992-l6l24pco	7	4	recent	recent	JJ
cord-350992-l6l24pco	7	5	studies	study	NNS
cord-350992-l6l24pco	7	6	a	a	DT
cord-350992-l6l24pco	7	7	clinical	clinical	JJ
cord-350992-l6l24pco	7	8	improvement	improvement	NN
cord-350992-l6l24pco	7	9	in	in	IN
cord-350992-l6l24pco	7	10	COVID-19	COVID-19	NNP
cord-350992-l6l24pco	7	11	patients	patient	NNS
cord-350992-l6l24pco	7	12	has	have	VBZ
cord-350992-l6l24pco	7	13	been	be	VBN
cord-350992-l6l24pco	7	14	observed	observe	VBN
cord-350992-l6l24pco	7	15	,	,	,
cord-350992-l6l24pco	7	16	the	the	DT
cord-350992-l6l24pco	7	17	clinical	clinical	JJ
cord-350992-l6l24pco	7	18	efficacy	efficacy	NN
cord-350992-l6l24pco	7	19	of	of	IN
cord-350992-l6l24pco	7	20	CQ	CQ	NNP
cord-350992-l6l24pco	7	21	and	and	CC
cord-350992-l6l24pco	7	22	HCQ	HCQ	NNP
cord-350992-l6l24pco	7	23	in	in	IN
cord-350992-l6l24pco	7	24	COVID-19	COVID-19	NNP
cord-350992-l6l24pco	7	25	has	have	VBZ
cord-350992-l6l24pco	7	26	yet	yet	RB
cord-350992-l6l24pco	7	27	to	to	TO
cord-350992-l6l24pco	7	28	be	be	VB
cord-350992-l6l24pco	7	29	proven	prove	VBN
cord-350992-l6l24pco	7	30	with	with	IN
cord-350992-l6l24pco	7	31	randomized	randomized	JJ
cord-350992-l6l24pco	7	32	controlled	control	VBN
cord-350992-l6l24pco	7	33	studies	study	NNS
cord-350992-l6l24pco	7	34	,	,	,
cord-350992-l6l24pco	7	35	many	many	JJ
cord-350992-l6l24pco	7	36	of	of	IN
cord-350992-l6l24pco	7	37	which	which	WDT
cord-350992-l6l24pco	7	38	are	be	VBP
cord-350992-l6l24pco	7	39	currently	currently	RB
cord-350992-l6l24pco	7	40	ongoing	ongoing	JJ
cord-350992-l6l24pco	7	41	,	,	,
cord-350992-l6l24pco	7	42	also	also	RB
cord-350992-l6l24pco	7	43	considering	consider	VBG
cord-350992-l6l24pco	7	44	pharmacokinetics	pharmacokinetic	NNS
cord-350992-l6l24pco	7	45	,	,	,
cord-350992-l6l24pco	7	46	optimal	optimal	JJ
cord-350992-l6l24pco	7	47	dosing	dosing	NN
cord-350992-l6l24pco	7	48	regimen	regimen	NN
cord-350992-l6l24pco	7	49	,	,	,
cord-350992-l6l24pco	7	50	therapeutic	therapeutic	JJ
cord-350992-l6l24pco	7	51	level	level	NN
cord-350992-l6l24pco	7	52	and	and	CC
cord-350992-l6l24pco	7	53	duration	duration	NN
cord-350992-l6l24pco	7	54	of	of	IN
cord-350992-l6l24pco	7	55	treatment	treatment	NN
cord-350992-l6l24pco	7	56	and	and	CC
cord-350992-l6l24pco	7	57	taking	take	VBG
cord-350992-l6l24pco	7	58	into	into	IN
cord-350992-l6l24pco	7	59	account	account	NN
cord-350992-l6l24pco	7	60	patients	patient	NNS
cord-350992-l6l24pco	7	61	with	with	IN
cord-350992-l6l24pco	7	62	different	different	JJ
cord-350992-l6l24pco	7	63	severity	severity	NN
cord-350992-l6l24pco	7	64	degrees	degree	NNS
cord-350992-l6l24pco	7	65	of	of	IN
cord-350992-l6l24pco	7	66	disease	disease	NN
cord-350992-l6l24pco	7	67	.	.	.
cord-350992-l6l24pco	8	1	Here	here	RB
cord-350992-l6l24pco	8	2	we	-PRON-	PRP
cord-350992-l6l24pco	8	3	review	review	VBP
cord-350992-l6l24pco	8	4	what	what	WP
cord-350992-l6l24pco	8	5	is	be	VBZ
cord-350992-l6l24pco	8	6	currently	currently	RB
cord-350992-l6l24pco	8	7	known	know	VBN
cord-350992-l6l24pco	8	8	on	on	IN
cord-350992-l6l24pco	8	9	the	the	DT
cord-350992-l6l24pco	8	10	mechanisms	mechanism	NNS
cord-350992-l6l24pco	8	11	of	of	IN
cord-350992-l6l24pco	8	12	action	action	NN
cord-350992-l6l24pco	8	13	of	of	IN
cord-350992-l6l24pco	8	14	CQ	CQ	NNP
cord-350992-l6l24pco	8	15	and	and	CC
cord-350992-l6l24pco	8	16	HCQ	HCQ	NNP
cord-350992-l6l24pco	8	17	as	as	IN
cord-350992-l6l24pco	8	18	anti	anti	JJ
cord-350992-l6l24pco	8	19	-	-	JJ
cord-350992-l6l24pco	8	20	viral	viral	JJ
cord-350992-l6l24pco	8	21	,	,	,
cord-350992-l6l24pco	8	22	anti	anti	JJ
cord-350992-l6l24pco	8	23	-	-	JJ
cord-350992-l6l24pco	8	24	inflammatory	inflammatory	JJ
cord-350992-l6l24pco	8	25	and	and	CC
cord-350992-l6l24pco	8	26	anti	anti	JJ
cord-350992-l6l24pco	8	27	-	-	JJ
cord-350992-l6l24pco	8	28	thrombotic	thrombotic	JJ
cord-350992-l6l24pco	8	29	drugs	drug	NNS
cord-350992-l6l24pco	8	30	and	and	CC
cord-350992-l6l24pco	8	31	discuss	discuss	VB
cord-350992-l6l24pco	8	32	the	the	DT
cord-350992-l6l24pco	8	33	up	up	NN
cord-350992-l6l24pco	8	34	-	-	HYPH
cord-350992-l6l24pco	8	35	to	to	IN
cord-350992-l6l24pco	8	36	-	-	HYPH
cord-350992-l6l24pco	8	37	date	date	NN
cord-350992-l6l24pco	8	38	experimental	experimental	JJ
cord-350992-l6l24pco	8	39	evidence	evidence	NN
cord-350992-l6l24pco	8	40	on	on	IN
cord-350992-l6l24pco	8	41	the	the	DT
cord-350992-l6l24pco	8	42	potential	potential	JJ
cord-350992-l6l24pco	8	43	mechanisms	mechanism	NNS
cord-350992-l6l24pco	8	44	of	of	IN
cord-350992-l6l24pco	8	45	action	action	NN
cord-350992-l6l24pco	8	46	of	of	IN
cord-350992-l6l24pco	8	47	CQ	CQ	NNP
cord-350992-l6l24pco	8	48	/	/	SYM
cord-350992-l6l24pco	8	49	HCQ	HCQ	NNP
cord-350992-l6l24pco	8	50	in	in	IN
cord-350992-l6l24pco	8	51	Sars	Sars	NNP
cord-350992-l6l24pco	8	52	-	-	HYPH
cord-350992-l6l24pco	8	53	Cov2	Cov2	NNP
cord-350992-l6l24pco	8	54	infection	infection	NN
cord-350992-l6l24pco	8	55	and	and	CC
cord-350992-l6l24pco	8	56	the	the	DT
cord-350992-l6l24pco	8	57	current	current	JJ
cord-350992-l6l24pco	8	58	clinical	clinical	JJ
cord-350992-l6l24pco	8	59	knowledge	knowledge	NN
cord-350992-l6l24pco	8	60	on	on	IN
cord-350992-l6l24pco	8	61	their	-PRON-	PRP$
cord-350992-l6l24pco	8	62	efficacy	efficacy	NN
cord-350992-l6l24pco	8	63	in	in	IN
cord-350992-l6l24pco	8	64	the	the	DT
cord-350992-l6l24pco	8	65	treatment	treatment	NN
cord-350992-l6l24pco	8	66	of	of	IN
cord-350992-l6l24pco	8	67	COVID-19	covid-19	JJ
cord-350992-l6l24pco	8	68	patients	patient	NNS
cord-350992-l6l24pco	8	69	.	.	.
cord-350992-l6l24pco	9	1	Given	give	VBN
cord-350992-l6l24pco	9	2	the	the	DT
cord-350992-l6l24pco	9	3	role	role	NN
cord-350992-l6l24pco	9	4	of	of	IN
cord-350992-l6l24pco	9	5	iron	iron	NN
cord-350992-l6l24pco	9	6	in	in	IN
cord-350992-l6l24pco	9	7	several	several	JJ
cord-350992-l6l24pco	9	8	human	human	JJ
cord-350992-l6l24pco	9	9	viral	viral	JJ
cord-350992-l6l24pco	9	10	infections	infection	NNS
cord-350992-l6l24pco	9	11	,	,	,
cord-350992-l6l24pco	9	12	we	-PRON-	PRP
cord-350992-l6l24pco	9	13	also	also	RB
cord-350992-l6l24pco	9	14	propose	propose	VBP
cord-350992-l6l24pco	9	15	a	a	DT
cord-350992-l6l24pco	9	16	different	different	JJ
cord-350992-l6l24pco	9	17	insight	insight	NN
cord-350992-l6l24pco	9	18	into	into	IN
cord-350992-l6l24pco	9	19	a	a	DT
cord-350992-l6l24pco	9	20	number	number	NN
cord-350992-l6l24pco	9	21	of	of	IN
cord-350992-l6l24pco	9	22	CQ	CQ	NNP
cord-350992-l6l24pco	9	23	and	and	CC
cord-350992-l6l24pco	9	24	HCQ	HCQ	NNP
cord-350992-l6l24pco	9	25	pharmacological	pharmacological	JJ
cord-350992-l6l24pco	9	26	effects	effect	NNS
cord-350992-l6l24pco	9	27	,	,	,
cord-350992-l6l24pco	9	28	suggesting	suggest	VBG
cord-350992-l6l24pco	9	29	a	a	DT
cord-350992-l6l24pco	9	30	potential	potential	JJ
cord-350992-l6l24pco	9	31	involvement	involvement	NN
cord-350992-l6l24pco	9	32	of	of	IN
cord-350992-l6l24pco	9	33	iron	iron	NN
cord-350992-l6l24pco	9	34	homeostasis	homeostasis	NN
cord-350992-l6l24pco	9	35	in	in	IN
cord-350992-l6l24pco	9	36	Sars	Sars	NNP
cord-350992-l6l24pco	9	37	-	-	HYPH
cord-350992-l6l24pco	9	38	Cov-2	Cov-2	NNP
cord-350992-l6l24pco	9	39	infection	infection	NN
cord-350992-l6l24pco	9	40	and	and	CC
cord-350992-l6l24pco	9	41	COVID-19	covid-19	VB
cord-350992-l6l24pco	9	42	clinical	clinical	JJ
cord-350992-l6l24pco	9	43	course	course	NN
cord-350992-l6l24pco	9	44	.	.	.
cord-350992-l6l24pco	10	1	Chloroquine	Chloroquine	NNP
cord-350992-l6l24pco	10	2	(	(	-LRB-
cord-350992-l6l24pco	10	3	CQ	CQ	NNP
cord-350992-l6l24pco	10	4	)	)	-RRB-
cord-350992-l6l24pco	10	5	and	and	CC
cord-350992-l6l24pco	10	6	its	-PRON-	PRP$
cord-350992-l6l24pco	10	7	hydroxy	hydroxy	JJ
cord-350992-l6l24pco	10	8	-	-	HYPH
cord-350992-l6l24pco	10	9	analogue	analogue	NN
cord-350992-l6l24pco	10	10	hydroxychloroquine	hydroxychloroquine	NN
cord-350992-l6l24pco	10	11	(	(	-LRB-
cord-350992-l6l24pco	10	12	HCQ	HCQ	NNP
cord-350992-l6l24pco	10	13	)	)	-RRB-
cord-350992-l6l24pco	10	14	,	,	,
cord-350992-l6l24pco	10	15	both	both	DT
cord-350992-l6l24pco	10	16	4-aminoquinolines	4-aminoquinolines	CD
cord-350992-l6l24pco	10	17	,	,	,
cord-350992-l6l24pco	10	18	have	have	VBP
cord-350992-l6l24pco	10	19	been	be	VBN
cord-350992-l6l24pco	10	20	extensively	extensively	RB
cord-350992-l6l24pco	10	21	used	use	VBN
cord-350992-l6l24pco	10	22	in	in	IN
cord-350992-l6l24pco	10	23	the	the	DT
cord-350992-l6l24pco	10	24	treatment	treatment	NN
cord-350992-l6l24pco	10	25	of	of	IN
cord-350992-l6l24pco	10	26	malaria	malaria	NN
cord-350992-l6l24pco	10	27	in	in	IN
cord-350992-l6l24pco	10	28	the	the	DT
cord-350992-l6l24pco	10	29	last	last	JJ
cord-350992-l6l24pco	10	30	century	century	NN
cord-350992-l6l24pco	10	31	,	,	,
cord-350992-l6l24pco	10	32	but	but	CC
cord-350992-l6l24pco	10	33	the	the	DT
cord-350992-l6l24pco	10	34	continuous	continuous	JJ
cord-350992-l6l24pco	10	35	emergence	emergence	NN
cord-350992-l6l24pco	10	36	of	of	IN
cord-350992-l6l24pco	10	37	drugresistant	drugresistant	JJ
cord-350992-l6l24pco	10	38	strains	strain	NNS
cord-350992-l6l24pco	10	39	of	of	IN
cord-350992-l6l24pco	10	40	Plasmodium	Plasmodium	NNP
cord-350992-l6l24pco	10	41	falciparum	falciparum	NNS
cord-350992-l6l24pco	10	42	has	have	VBZ
cord-350992-l6l24pco	10	43	accelerated	accelerate	VBN
cord-350992-l6l24pco	10	44	the	the	DT
cord-350992-l6l24pco	10	45	development	development	NN
cord-350992-l6l24pco	10	46	of	of	IN
cord-350992-l6l24pco	10	47	new	new	JJ
cord-350992-l6l24pco	10	48	antimalarial	antimalarial	JJ
cord-350992-l6l24pco	10	49	drugs	drug	NNS
cord-350992-l6l24pco	10	50	.	.	.
cord-350992-l6l24pco	11	1	Nevertheless	nevertheless	RB
cord-350992-l6l24pco	11	2	,	,	,
cord-350992-l6l24pco	11	3	these	these	DT
cord-350992-l6l24pco	11	4	compounds	compound	NNS
cord-350992-l6l24pco	11	5	,	,	,
cord-350992-l6l24pco	11	6	particularly	particularly	RB
cord-350992-l6l24pco	11	7	the	the	DT
cord-350992-l6l24pco	11	8	less	less	RBR
cord-350992-l6l24pco	11	9	toxic	toxic	JJ
cord-350992-l6l24pco	11	10	HCQ	HCQ	NNP
cord-350992-l6l24pco	11	11	,	,	,
cord-350992-l6l24pco	11	12	are	be	VBP
cord-350992-l6l24pco	11	13	currently	currently	RB
cord-350992-l6l24pco	11	14	widely	widely	RB
cord-350992-l6l24pco	11	15	used	use	VBN
cord-350992-l6l24pco	11	16	to	to	TO
cord-350992-l6l24pco	11	17	treat	treat	VB
cord-350992-l6l24pco	11	18	autoimmune	autoimmune	JJ
cord-350992-l6l24pco	11	19	diseases	disease	NNS
cord-350992-l6l24pco	11	20	like	like	IN
cord-350992-l6l24pco	11	21	rheumatoid	rheumatoid	NN
cord-350992-l6l24pco	11	22	arthritis	arthritis	NN
cord-350992-l6l24pco	11	23	(	(	-LRB-
cord-350992-l6l24pco	11	24	RA	RA	NNP
cord-350992-l6l24pco	11	25	)	)	-RRB-
cord-350992-l6l24pco	11	26	,	,	,
cord-350992-l6l24pco	11	27	systemic	systemic	JJ
cord-350992-l6l24pco	11	28	lupus	lupus	NN
cord-350992-l6l24pco	11	29	erythematosus	erythematosus	NN
cord-350992-l6l24pco	11	30	(	(	-LRB-
cord-350992-l6l24pco	11	31	SLE	SLE	NNP
cord-350992-l6l24pco	11	32	)	)	-RRB-
cord-350992-l6l24pco	11	33	and	and	CC
cord-350992-l6l24pco	11	34	antiphospholipid	antiphospholipid	NNP
cord-350992-l6l24pco	11	35	syndrome	syndrome	NN
cord-350992-l6l24pco	11	36	(	(	-LRB-
cord-350992-l6l24pco	11	37	APS	APS	NNP
cord-350992-l6l24pco	11	38	)	)	-RRB-
cord-350992-l6l24pco	11	39	,	,	,
cord-350992-l6l24pco	11	40	due	due	IN
cord-350992-l6l24pco	11	41	to	to	IN
cord-350992-l6l24pco	11	42	their	-PRON-	PRP$
cord-350992-l6l24pco	11	43	immunomodulatory	immunomodulatory	JJ
cord-350992-l6l24pco	11	44	and	and	CC
cord-350992-l6l24pco	11	45	anti	anti	JJ
cord-350992-l6l24pco	11	46	-	-	JJ
cord-350992-l6l24pco	11	47	thrombotic	thrombotic	JJ
cord-350992-l6l24pco	11	48	properties	property	NNS
cord-350992-l6l24pco	11	49	.	.	.
cord-350992-l6l24pco	12	1	CQ	CQ	NNP
cord-350992-l6l24pco	12	2	and	and	CC
cord-350992-l6l24pco	12	3	HCQ	HCQ	NNP
cord-350992-l6l24pco	12	4	have	have	VBP
cord-350992-l6l24pco	12	5	also	also	RB
cord-350992-l6l24pco	12	6	been	be	VBN
cord-350992-l6l24pco	12	7	proposed	propose	VBN
cord-350992-l6l24pco	12	8	for	for	IN
cord-350992-l6l24pco	12	9	the	the	DT
cord-350992-l6l24pco	12	10	treatment	treatment	NN
cord-350992-l6l24pco	12	11	of	of	IN
cord-350992-l6l24pco	12	12	viral	viral	JJ
cord-350992-l6l24pco	12	13	infections	infection	NNS
cord-350992-l6l24pco	12	14	,	,	,
cord-350992-l6l24pco	12	15	since	since	IN
cord-350992-l6l24pco	12	16	they	-PRON-	PRP
cord-350992-l6l24pco	12	17	have	have	VBP
cord-350992-l6l24pco	12	18	been	be	VBN
cord-350992-l6l24pco	12	19	demonstrated	demonstrate	VBN
cord-350992-l6l24pco	12	20	to	to	TO
cord-350992-l6l24pco	12	21	directly	directly	RB
cord-350992-l6l24pco	12	22	inhibit	inhibit	VB
cord-350992-l6l24pco	12	23	viral	viral	JJ
cord-350992-l6l24pco	12	24	entry	entry	NN
cord-350992-l6l24pco	12	25	and	and	CC
cord-350992-l6l24pco	12	26	spread	spread	VBD
cord-350992-l6l24pco	12	27	in	in	IN
cord-350992-l6l24pco	12	28	several	several	JJ
cord-350992-l6l24pco	12	29	in	in	IN
cord-350992-l6l24pco	12	30	vitro	vitro	FW
cord-350992-l6l24pco	12	31	and	and	CC
cord-350992-l6l24pco	12	32	in	in	IN
cord-350992-l6l24pco	12	33	vivo	vivo	NN
cord-350992-l6l24pco	12	34	models	model	NNS
cord-350992-l6l24pco	12	35	.	.	.
cord-350992-l6l24pco	13	1	Treatment	treatment	NN
cord-350992-l6l24pco	13	2	with	with	IN
cord-350992-l6l24pco	13	3	these	these	DT
cord-350992-l6l24pco	13	4	drugs	drug	NNS
cord-350992-l6l24pco	13	5	has	have	VBZ
cord-350992-l6l24pco	13	6	then	then	RB
cord-350992-l6l24pco	13	7	been	be	VBN
cord-350992-l6l24pco	13	8	proposed	propose	VBN
cord-350992-l6l24pco	13	9	for	for	IN
cord-350992-l6l24pco	13	10	several	several	JJ
cord-350992-l6l24pco	13	11	viruses	virus	NNS
cord-350992-l6l24pco	13	12	in	in	IN
cord-350992-l6l24pco	13	13	humans	human	NNS
cord-350992-l6l24pco	13	14	,	,	,
cord-350992-l6l24pco	13	15	including	include	VBG
cord-350992-l6l24pco	13	16	coronaviruses	coronaviruse	NNS
cord-350992-l6l24pco	13	17	like	like	IN
cord-350992-l6l24pco	13	18	Sars	Sars	NNP
cord-350992-l6l24pco	13	19	-	-	HYPH
cord-350992-l6l24pco	13	20	Cov	Cov	NNP
cord-350992-l6l24pco	13	21	and	and	CC
cord-350992-l6l24pco	13	22	Sars	Sars	NNP
cord-350992-l6l24pco	13	23	-	-	HYPH
cord-350992-l6l24pco	13	24	Cov-2	Cov-2	NNP
cord-350992-l6l24pco	13	25	.	.	.
cord-350992-l6l24pco	14	1	Nonetheless	nonetheless	RB
cord-350992-l6l24pco	14	2	,	,	,
cord-350992-l6l24pco	14	3	a	a	DT
cord-350992-l6l24pco	14	4	clear	clear	JJ
cord-350992-l6l24pco	14	5	evidence	evidence	NN
cord-350992-l6l24pco	14	6	of	of	IN
cord-350992-l6l24pco	14	7	their	-PRON-	PRP$
cord-350992-l6l24pco	14	8	utility	utility	NN
cord-350992-l6l24pco	14	9	in	in	IN
cord-350992-l6l24pco	14	10	human	human	JJ
cord-350992-l6l24pco	14	11	viral	viral	JJ
cord-350992-l6l24pco	14	12	infectious	infectious	JJ
cord-350992-l6l24pco	14	13	diseases	disease	NNS
cord-350992-l6l24pco	14	14	still	still	RB
cord-350992-l6l24pco	14	15	lacks	lack	VBZ
cord-350992-l6l24pco	14	16	[	[	-LRB-
cord-350992-l6l24pco	14	17	1	1	CD
cord-350992-l6l24pco	14	18	]	]	-RRB-
cord-350992-l6l24pco	14	19	.	.	.
cord-350992-l6l24pco	15	1	Translation	translation	NN
cord-350992-l6l24pco	15	2	from	from	IN
cord-350992-l6l24pco	15	3	laboratory	laboratory	NN
cord-350992-l6l24pco	15	4	to	to	IN
cord-350992-l6l24pco	15	5	clinic	clinic	NN
cord-350992-l6l24pco	15	6	should	should	MD
cord-350992-l6l24pco	15	7	be	be	VB
cord-350992-l6l24pco	15	8	based	base	VBN
cord-350992-l6l24pco	15	9	on	on	IN
cord-350992-l6l24pco	15	10	detailed	detailed	JJ
cord-350992-l6l24pco	15	11	analysis	analysis	NN
cord-350992-l6l24pco	15	12	of	of	IN
cord-350992-l6l24pco	15	13	results	result	NNS
cord-350992-l6l24pco	15	14	from	from	IN
cord-350992-l6l24pco	15	15	randomized	randomized	JJ
cord-350992-l6l24pco	15	16	controlled	control	VBN
cord-350992-l6l24pco	15	17	studies	study	NNS
cord-350992-l6l24pco	15	18	and	and	CC
cord-350992-l6l24pco	15	19	observational	observational	JJ
cord-350992-l6l24pco	15	20	outcome	outcome	NN
cord-350992-l6l24pco	15	21	registries	registry	NNS
cord-350992-l6l24pco	15	22	focused	focus	VBD
cord-350992-l6l24pco	15	23	on	on	IN
cord-350992-l6l24pco	15	24	the	the	DT
cord-350992-l6l24pco	15	25	efficacy	efficacy	NN
cord-350992-l6l24pco	15	26	,	,	,
cord-350992-l6l24pco	15	27	duration	duration	NN
cord-350992-l6l24pco	15	28	and	and	CC
cord-350992-l6l24pco	15	29	toxicities	toxicity	NNS
cord-350992-l6l24pco	15	30	of	of	IN
cord-350992-l6l24pco	15	31	treatments	treatment	NNS
cord-350992-l6l24pco	15	32	with	with	IN
cord-350992-l6l24pco	15	33	these	these	DT
cord-350992-l6l24pco	15	34	drugs	drug	NNS
cord-350992-l6l24pco	15	35	that	that	WDT
cord-350992-l6l24pco	15	36	could	could	MD
cord-350992-l6l24pco	15	37	be	be	VB
cord-350992-l6l24pco	15	38	useful	useful	JJ
cord-350992-l6l24pco	15	39	to	to	TO
cord-350992-l6l24pco	15	40	understand	understand	VB
cord-350992-l6l24pco	15	41	their	-PRON-	PRP$
cord-350992-l6l24pco	15	42	real	real	JJ
cord-350992-l6l24pco	15	43	effectiveness	effectiveness	NN
cord-350992-l6l24pco	15	44	.	.	.
cord-350992-l6l24pco	16	1	Here	here	RB
cord-350992-l6l24pco	16	2	we	-PRON-	PRP
cord-350992-l6l24pco	16	3	review	review	VBP
cord-350992-l6l24pco	16	4	the	the	DT
cord-350992-l6l24pco	16	5	current	current	JJ
cord-350992-l6l24pco	16	6	knowledge	knowledge	NN
cord-350992-l6l24pco	16	7	on	on	IN
cord-350992-l6l24pco	16	8	the	the	DT
cord-350992-l6l24pco	16	9	mechanisms	mechanism	NNS
cord-350992-l6l24pco	16	10	of	of	IN
cord-350992-l6l24pco	16	11	action	action	NN
cord-350992-l6l24pco	16	12	of	of	IN
cord-350992-l6l24pco	16	13	CQ	CQ	NNP
cord-350992-l6l24pco	16	14	and	and	CC
cord-350992-l6l24pco	16	15	HCQ	HCQ	NNP
cord-350992-l6l24pco	16	16	as	as	IN
cord-350992-l6l24pco	16	17	anti	anti	JJ
cord-350992-l6l24pco	16	18	-	-	JJ
cord-350992-l6l24pco	16	19	viral	viral	JJ
cord-350992-l6l24pco	16	20	,	,	,
cord-350992-l6l24pco	16	21	antiinflammatory	antiinflammatory	JJ
cord-350992-l6l24pco	16	22	and	and	CC
cord-350992-l6l24pco	16	23	anti	anti	JJ
cord-350992-l6l24pco	16	24	-	-	JJ
cord-350992-l6l24pco	16	25	thrombotic	thrombotic	JJ
cord-350992-l6l24pco	16	26	drugs	drug	NNS
cord-350992-l6l24pco	16	27	and	and	CC
cord-350992-l6l24pco	16	28	discuss	discuss	VB
cord-350992-l6l24pco	16	29	the	the	DT
cord-350992-l6l24pco	16	30	current	current	JJ
cord-350992-l6l24pco	16	31	experimental	experimental	JJ
cord-350992-l6l24pco	16	32	evidence	evidence	NN
cord-350992-l6l24pco	16	33	on	on	IN
cord-350992-l6l24pco	16	34	the	the	DT
cord-350992-l6l24pco	16	35	potential	potential	JJ
cord-350992-l6l24pco	16	36	mechanisms	mechanism	NNS
cord-350992-l6l24pco	16	37	of	of	IN
cord-350992-l6l24pco	16	38	action	action	NN
cord-350992-l6l24pco	16	39	of	of	IN
cord-350992-l6l24pco	16	40	CQ	CQ	NNP
cord-350992-l6l24pco	16	41	/	/	SYM
cord-350992-l6l24pco	16	42	HCQ	HCQ	NNP
cord-350992-l6l24pco	16	43	on	on	IN
cord-350992-l6l24pco	16	44	Sars	Sars	NNP
cord-350992-l6l24pco	16	45	-	-	HYPH
cord-350992-l6l24pco	16	46	Cov2	Cov2	NNP
cord-350992-l6l24pco	16	47	.	.	.
cord-350992-l6l24pco	17	1	We	-PRON-	PRP
cord-350992-l6l24pco	17	2	also	also	RB
cord-350992-l6l24pco	17	3	propose	propose	VBP
cord-350992-l6l24pco	17	4	a	a	DT
cord-350992-l6l24pco	17	5	different	different	JJ
cord-350992-l6l24pco	17	6	insight	insight	NN
cord-350992-l6l24pco	17	7	into	into	IN
cord-350992-l6l24pco	17	8	some	some	DT
cord-350992-l6l24pco	17	9	of	of	IN
cord-350992-l6l24pco	17	10	CQ	CQ	NNP
cord-350992-l6l24pco	17	11	and	and	CC
cord-350992-l6l24pco	17	12	HCQ	HCQ	NNP
cord-350992-l6l24pco	17	13	effects	effect	NNS
cord-350992-l6l24pco	17	14	,	,	,
cord-350992-l6l24pco	17	15	suggesting	suggest	VBG
cord-350992-l6l24pco	17	16	a	a	DT
cord-350992-l6l24pco	17	17	potential	potential	JJ
cord-350992-l6l24pco	17	18	role	role	NN
cord-350992-l6l24pco	17	19	of	of	IN
cord-350992-l6l24pco	17	20	iron	iron	NN
cord-350992-l6l24pco	17	21	homeostasis	homeostasis	NN
cord-350992-l6l24pco	17	22	in	in	IN
cord-350992-l6l24pco	17	23	Sars	Sars	NNP
cord-350992-l6l24pco	17	24	-	-	HYPH
cord-350992-l6l24pco	17	25	Cov-2	Cov-2	NNP
cord-350992-l6l24pco	17	26	disease	disease	NN
cord-350992-l6l24pco	17	27	(	(	-LRB-
cord-350992-l6l24pco	17	28	COVID-19	COVID-19	NNP
cord-350992-l6l24pco	17	29	)	)	-RRB-
cord-350992-l6l24pco	17	30	,	,	,
cord-350992-l6l24pco	17	31	similarly	similarly	RB
cord-350992-l6l24pco	17	32	to	to	IN
cord-350992-l6l24pco	17	33	several	several	JJ
cord-350992-l6l24pco	17	34	other	other	JJ
cord-350992-l6l24pco	17	35	human	human	JJ
cord-350992-l6l24pco	17	36	viral	viral	JJ
cord-350992-l6l24pco	17	37	infections	infection	NNS
cord-350992-l6l24pco	17	38	[	[	-LRB-
cord-350992-l6l24pco	17	39	2	2	CD
cord-350992-l6l24pco	17	40	]	]	-RRB-
cord-350992-l6l24pco	17	41	[	[	-LRB-
cord-350992-l6l24pco	17	42	3	3	CD
cord-350992-l6l24pco	17	43	]	]	-RRB-
cord-350992-l6l24pco	17	44	[	[	-LRB-
cord-350992-l6l24pco	17	45	4	4	CD
cord-350992-l6l24pco	17	46	]	]	-RRB-
cord-350992-l6l24pco	17	47	.	.	.
cord-350992-l6l24pco	18	1	Finally	finally	RB
cord-350992-l6l24pco	18	2	,	,	,
cord-350992-l6l24pco	18	3	we	-PRON-	PRP
cord-350992-l6l24pco	18	4	briefly	briefly	RB
cord-350992-l6l24pco	18	5	review	review	VBP
cord-350992-l6l24pco	18	6	and	and	CC
cord-350992-l6l24pco	18	7	discuss	discuss	VB
cord-350992-l6l24pco	18	8	the	the	DT
cord-350992-l6l24pco	18	9	current	current	JJ
cord-350992-l6l24pco	18	10	knowledge	knowledge	NN
cord-350992-l6l24pco	18	11	on	on	IN
cord-350992-l6l24pco	18	12	their	-PRON-	PRP$
cord-350992-l6l24pco	18	13	efficacy	efficacy	NN
cord-350992-l6l24pco	18	14	in	in	IN
cord-350992-l6l24pco	18	15	the	the	DT
cord-350992-l6l24pco	18	16	treatment	treatment	NN
cord-350992-l6l24pco	18	17	of	of	IN
cord-350992-l6l24pco	18	18	patients	patient	NNS
cord-350992-l6l24pco	18	19	with	with	IN
cord-350992-l6l24pco	18	20	COVID-19	COVID-19	NNP
cord-350992-l6l24pco	18	21	.	.	.
cord-350992-l6l24pco	19	1	We	-PRON-	PRP
cord-350992-l6l24pco	19	2	conducted	conduct	VBD
cord-350992-l6l24pco	19	3	a	a	DT
cord-350992-l6l24pco	19	4	literature	literature	NN
cord-350992-l6l24pco	19	5	search	search	NN
cord-350992-l6l24pco	19	6	using	use	VBG
cord-350992-l6l24pco	19	7	different	different	JJ
cord-350992-l6l24pco	19	8	database	database	NN
cord-350992-l6l24pco	19	9	(	(	-LRB-
cord-350992-l6l24pco	19	10	PubMed	PubMed	NNP
cord-350992-l6l24pco	19	11	,	,	,
cord-350992-l6l24pco	19	12	Science	Science	NNP
cord-350992-l6l24pco	19	13	Direct	Direct	NNP
cord-350992-l6l24pco	19	14	and	and	CC
cord-350992-l6l24pco	19	15	Web	web	NN
cord-350992-l6l24pco	19	16	of	of	IN
cord-350992-l6l24pco	19	17	Science	Science	NNP
cord-350992-l6l24pco	19	18	)	)	-RRB-
cord-350992-l6l24pco	19	19	up	up	IN
cord-350992-l6l24pco	19	20	to	to	IN
cord-350992-l6l24pco	19	21	April	April	NNP
cord-350992-l6l24pco	19	22	20	20	CD
cord-350992-l6l24pco	19	23	th	th	CD
cord-350992-l6l24pco	19	24	2020	2020	CD
cord-350992-l6l24pco	19	25	.	.	.
cord-350992-l6l24pco	20	1	The	the	DT
cord-350992-l6l24pco	20	2	search	search	NN
cord-350992-l6l24pco	20	3	strategy	strategy	NN
cord-350992-l6l24pco	20	4	was	be	VBD
cord-350992-l6l24pco	20	5	to	to	TO
cord-350992-l6l24pco	20	6	use	use	VB
cord-350992-l6l24pco	20	7	different	different	JJ
cord-350992-l6l24pco	20	8	search	search	NN
cord-350992-l6l24pco	20	9	terms	term	NNS
cord-350992-l6l24pco	20	10	alone	alone	RB
cord-350992-l6l24pco	20	11	and	and	CC
cord-350992-l6l24pco	20	12	in	in	IN
cord-350992-l6l24pco	20	13	any	any	DT
cord-350992-l6l24pco	20	14	combination	combination	NN
cord-350992-l6l24pco	20	15	,	,	,
cord-350992-l6l24pco	20	16	such	such	JJ
cord-350992-l6l24pco	20	17	as	as	IN
cord-350992-l6l24pco	20	18	"	"	``
cord-350992-l6l24pco	20	19	Sars	Sars	NNP
cord-350992-l6l24pco	20	20	-	-	HYPH
cord-350992-l6l24pco	20	21	Cov-2	Cov-2	NNP
cord-350992-l6l24pco	20	22	disease	disease	NN
cord-350992-l6l24pco	20	23	"	"	''
cord-350992-l6l24pco	20	24	,	,	,
cord-350992-l6l24pco	20	25	"	"	``
cord-350992-l6l24pco	20	26	COVID-19	COVID-19	NNP
cord-350992-l6l24pco	20	27	"	"	''
cord-350992-l6l24pco	20	28	,	,	,
cord-350992-l6l24pco	20	29	"	"	``
cord-350992-l6l24pco	20	30	Sars	Sars	NNP
cord-350992-l6l24pco	20	31	-	-	HYPH
cord-350992-l6l24pco	20	32	Cov-2	Cov-2	NNP
cord-350992-l6l24pco	20	33	"	"	''
cord-350992-l6l24pco	20	34	,	,	,
cord-350992-l6l24pco	20	35	"	"	``
cord-350992-l6l24pco	20	36	coronavirus	coronavirus	NN
cord-350992-l6l24pco	20	37	"	"	''
cord-350992-l6l24pco	20	38	,	,	,
cord-350992-l6l24pco	20	39	"	"	''
cord-350992-l6l24pco	20	40	clinical	clinical	JJ
cord-350992-l6l24pco	20	41	trial	trial	NN
cord-350992-l6l24pco	20	42	"	"	''
cord-350992-l6l24pco	20	43	,	,	,
cord-350992-l6l24pco	20	44	"	"	``
cord-350992-l6l24pco	20	45	treatment	treatment	NN
cord-350992-l6l24pco	20	46	"	"	''
cord-350992-l6l24pco	20	47	,	,	,
cord-350992-l6l24pco	20	48	"	"	``
cord-350992-l6l24pco	20	49	drug	drug	NN
cord-350992-l6l24pco	20	50	"	"	''
cord-350992-l6l24pco	20	51	,	,	,
cord-350992-l6l24pco	20	52	"	"	``
cord-350992-l6l24pco	20	53	chloroquine	chloroquine	NN
cord-350992-l6l24pco	20	54	"	"	''
cord-350992-l6l24pco	20	55	,	,	,
cord-350992-l6l24pco	20	56	"	"	``
cord-350992-l6l24pco	20	57	hydroxychloroquine	hydroxychloroquine	NNP
cord-350992-l6l24pco	20	58	"	"	''
cord-350992-l6l24pco	20	59	,	,	,
cord-350992-l6l24pco	20	60	"	"	``
cord-350992-l6l24pco	20	61	iron	iron	NN
cord-350992-l6l24pco	20	62	"	"	''
cord-350992-l6l24pco	20	63	,	,	,
cord-350992-l6l24pco	20	64	"	"	``
cord-350992-l6l24pco	20	65	virus	virus	NN
cord-350992-l6l24pco	20	66	"	"	''
cord-350992-l6l24pco	20	67	,	,	,
cord-350992-l6l24pco	20	68	"	"	``
cord-350992-l6l24pco	20	69	viral	viral	JJ
cord-350992-l6l24pco	20	70	entry	entry	NN
cord-350992-l6l24pco	20	71	"	"	''
cord-350992-l6l24pco	20	72	,	,	,
cord-350992-l6l24pco	20	73	"	"	``
cord-350992-l6l24pco	20	74	viral	viral	JJ
cord-350992-l6l24pco	20	75	spread	spread	NN
cord-350992-l6l24pco	20	76	"	"	''
cord-350992-l6l24pco	20	77	,	,	,
cord-350992-l6l24pco	20	78	"	"	''
cord-350992-l6l24pco	20	79	anti	anti	JJ
cord-350992-l6l24pco	20	80	-	-	JJ
cord-350992-l6l24pco	20	81	viral	viral	JJ
cord-350992-l6l24pco	20	82	activity	activity	NN
cord-350992-l6l24pco	20	83	"	"	''
cord-350992-l6l24pco	20	84	,	,	,
cord-350992-l6l24pco	20	85	"	"	``
cord-350992-l6l24pco	20	86	infection	infection	NN
cord-350992-l6l24pco	20	87	"	"	''
cord-350992-l6l24pco	20	88	,	,	,
cord-350992-l6l24pco	20	89	"	"	``
cord-350992-l6l24pco	20	90	inflammation	inflammation	NN
cord-350992-l6l24pco	20	91	"	"	''
cord-350992-l6l24pco	20	92	,	,	,
cord-350992-l6l24pco	20	93	"	"	``
cord-350992-l6l24pco	20	94	immunity	immunity	NN
cord-350992-l6l24pco	20	95	"	"	''
cord-350992-l6l24pco	20	96	,	,	,
cord-350992-l6l24pco	20	97	"	"	``
cord-350992-l6l24pco	20	98	innate	innate	JJ
cord-350992-l6l24pco	20	99	immunity	immunity	NN
cord-350992-l6l24pco	20	100	"	"	''
cord-350992-l6l24pco	20	101	,	,	,
cord-350992-l6l24pco	20	102	"	"	``
cord-350992-l6l24pco	20	103	cytokine	cytokine	NN
cord-350992-l6l24pco	20	104	"	"	''
cord-350992-l6l24pco	20	105	,	,	,
cord-350992-l6l24pco	20	106	"	"	``
cord-350992-l6l24pco	20	107	IL-6	IL-6	NNP
cord-350992-l6l24pco	20	108	"	"	''
cord-350992-l6l24pco	20	109	,	,	,
cord-350992-l6l24pco	20	110	"	"	``
cord-350992-l6l24pco	20	111	TNF-	TNF-	NNP
cord-350992-l6l24pco	20	112	"	"	''
cord-350992-l6l24pco	20	113	,	,	,
cord-350992-l6l24pco	20	114	"	"	``
cord-350992-l6l24pco	20	115	IL-1	IL-1	NNP
cord-350992-l6l24pco	20	116	"	"	''
cord-350992-l6l24pco	20	117	,	,	,
cord-350992-l6l24pco	20	118	"	"	``
cord-350992-l6l24pco	20	119	adaptive	adaptive	JJ
cord-350992-l6l24pco	20	120	immunity	immunity	NN
cord-350992-l6l24pco	20	121	"	"	''
cord-350992-l6l24pco	20	122	,	,	,
cord-350992-l6l24pco	20	123	"	"	``
cord-350992-l6l24pco	20	124	thrombosis	thrombosis	NN
cord-350992-l6l24pco	20	125	"	"	''
cord-350992-l6l24pco	20	126	,	,	,
cord-350992-l6l24pco	20	127	"	"	''
cord-350992-l6l24pco	20	128	in	in	FW
cord-350992-l6l24pco	20	129	vitro	vitro	FW
cord-350992-l6l24pco	20	130	"	"	''
cord-350992-l6l24pco	20	131	.	.	.
cord-350992-l6l24pco	21	1	Only	only	RB
cord-350992-l6l24pco	21	2	English	english	JJ
cord-350992-l6l24pco	21	3	articles	article	NNS
cord-350992-l6l24pco	21	4	with	with	IN
cord-350992-l6l24pco	21	5	available	available	JJ
cord-350992-l6l24pco	21	6	data	datum	NNS
cord-350992-l6l24pco	21	7	were	be	VBD
cord-350992-l6l24pco	21	8	included	include	VBN
cord-350992-l6l24pco	21	9	.	.	.
cord-350992-l6l24pco	22	1	Then	then	RB
cord-350992-l6l24pco	22	2	,	,	,
cord-350992-l6l24pco	22	3	CQ	CQ	NNP
cord-350992-l6l24pco	22	4	/	/	SYM
cord-350992-l6l24pco	22	5	HCQ	HCQ	NNP
cord-350992-l6l24pco	22	6	could	could	MD
cord-350992-l6l24pco	22	7	have	have	VB
cord-350992-l6l24pco	22	8	inhibitory	inhibitory	JJ
cord-350992-l6l24pco	22	9	effects	effect	NNS
cord-350992-l6l24pco	22	10	on	on	IN
cord-350992-l6l24pco	22	11	virus	virus	NN
cord-350992-l6l24pco	22	12	attachment	attachment	NN
cord-350992-l6l24pco	22	13	and	and	CC
cord-350992-l6l24pco	22	14	entry	entry	NN
cord-350992-l6l24pco	22	15	in	in	IN
cord-350992-l6l24pco	22	16	the	the	DT
cord-350992-l6l24pco	22	17	host	host	NN
cord-350992-l6l24pco	22	18	cell	cell	NN
cord-350992-l6l24pco	22	19	,	,	,
cord-350992-l6l24pco	22	20	possibly	possibly	RB
cord-350992-l6l24pco	22	21	resulting	result	VBG
cord-350992-l6l24pco	22	22	in	in	IN
cord-350992-l6l24pco	22	23	blocking	block	VBG
cord-350992-l6l24pco	22	24	the	the	DT
cord-350992-l6l24pco	22	25	viruses	virus	NNS
cord-350992-l6l24pco	22	26	in	in	IN
cord-350992-l6l24pco	22	27	endocytic	endocytic	JJ
cord-350992-l6l24pco	22	28	vesicles	vesicle	NNS
cord-350992-l6l24pco	22	29	.	.	.
cord-350992-l6l24pco	23	1	CQ	CQ	NNP
cord-350992-l6l24pco	23	2	/	/	SYM
cord-350992-l6l24pco	23	3	HCQ	HCQ	NNP
cord-350992-l6l24pco	23	4	have	have	VBP
cord-350992-l6l24pco	23	5	also	also	RB
cord-350992-l6l24pco	23	6	been	be	VBN
cord-350992-l6l24pco	23	7	shown	show	VBN
cord-350992-l6l24pco	23	8	to	to	TO
cord-350992-l6l24pco	23	9	display	display	VB
cord-350992-l6l24pco	23	10	anti	anti	JJ
cord-350992-l6l24pco	23	11	-	-	JJ
cord-350992-l6l24pco	23	12	viral	viral	JJ
cord-350992-l6l24pco	23	13	activity	activity	NN
cord-350992-l6l24pco	23	14	even	even	RB
cord-350992-l6l24pco	23	15	when	when	WRB
cord-350992-l6l24pco	23	16	administered	administer	VBN
cord-350992-l6l24pco	23	17	after	after	IN
cord-350992-l6l24pco	23	18	viral	viral	JJ
cord-350992-l6l24pco	23	19	infection	infection	NN
cord-350992-l6l24pco	23	20	.	.	.
cord-350992-l6l24pco	24	1	This	this	DT
cord-350992-l6l24pco	24	2	effect	effect	NN
cord-350992-l6l24pco	24	3	has	have	VBZ
cord-350992-l6l24pco	24	4	been	be	VBN
cord-350992-l6l24pco	24	5	observed	observe	VBN
cord-350992-l6l24pco	24	6	in	in	IN
cord-350992-l6l24pco	24	7	vitro	vitro	FW
cord-350992-l6l24pco	24	8	also	also	RB
cord-350992-l6l24pco	24	9	in	in	IN
cord-350992-l6l24pco	24	10	Sars	Sars	NNP
cord-350992-l6l24pco	24	11	-	-	HYPH
cord-350992-l6l24pco	24	12	Cov	Cov	NNP
cord-350992-l6l24pco	24	13	and	and	CC
cord-350992-l6l24pco	24	14	Sars	Sars	NNP
cord-350992-l6l24pco	24	15	-	-	HYPH
cord-350992-l6l24pco	24	16	Cov	Cov	NNP
cord-350992-l6l24pco	24	17	2	2	CD
cord-350992-l6l24pco	24	18	infections	infection	NNS
cord-350992-l6l24pco	24	19	[	[	-LRB-
cord-350992-l6l24pco	24	20	8	8	CD
cord-350992-l6l24pco	24	21	,	,	,
cord-350992-l6l24pco	24	22	9	9	CD
cord-350992-l6l24pco	24	23	,	,	,
cord-350992-l6l24pco	24	24	12	12	CD
cord-350992-l6l24pco	24	25	]	]	-RRB-
cord-350992-l6l24pco	24	26	.	.	.
cord-350992-l6l24pco	25	1	Further	further	JJ
cord-350992-l6l24pco	25	2	mechanisms	mechanism	NNS
cord-350992-l6l24pco	25	3	could	could	MD
cord-350992-l6l24pco	25	4	then	then	RB
cord-350992-l6l24pco	25	5	be	be	VB
cord-350992-l6l24pco	25	6	involved	involve	VBN
cord-350992-l6l24pco	25	7	in	in	IN
cord-350992-l6l24pco	25	8	antiviral	antiviral	JJ
cord-350992-l6l24pco	25	9	drug	drug	NN
cord-350992-l6l24pco	25	10	action	action	NN
cord-350992-l6l24pco	25	11	.	.	.
cord-350992-l6l24pco	26	1	Through	through	IN
cord-350992-l6l24pco	26	2	the	the	DT
cord-350992-l6l24pco	26	3	alkalization	alkalization	NN
cord-350992-l6l24pco	26	4	of	of	IN
cord-350992-l6l24pco	26	5	endosomes	endosome	NNS
cord-350992-l6l24pco	26	6	,	,	,
cord-350992-l6l24pco	26	7	CQ	CQ	NNP
cord-350992-l6l24pco	26	8	/	/	SYM
cord-350992-l6l24pco	26	9	HCQ	HCQ	NNP
cord-350992-l6l24pco	26	10	might	may	MD
cord-350992-l6l24pco	26	11	also	also	RB
cord-350992-l6l24pco	26	12	act	act	VB
cord-350992-l6l24pco	26	13	inhibiting	inhibit	VBG
cord-350992-l6l24pco	26	14	or	or	CC
cord-350992-l6l24pco	26	15	preventing	prevent	VBG
cord-350992-l6l24pco	26	16	endosomelysosome	endosomelysosome	NN
cord-350992-l6l24pco	26	17	membrane	membrane	NN
cord-350992-l6l24pco	26	18	fusion	fusion	NN
cord-350992-l6l24pco	26	19	that	that	WDT
cord-350992-l6l24pco	26	20	leads	lead	VBZ
cord-350992-l6l24pco	26	21	to	to	IN
cord-350992-l6l24pco	26	22	membrane	membrane	NN
cord-350992-l6l24pco	26	23	viral	viral	JJ
cord-350992-l6l24pco	26	24	receptor	receptor	NN
cord-350992-l6l24pco	26	25	recycling	recycling	NN
cord-350992-l6l24pco	26	26	,	,	,
cord-350992-l6l24pco	26	27	viral	viral	JJ
cord-350992-l6l24pco	26	28	uncoating	uncoating	NN
cord-350992-l6l24pco	26	29	and	and	CC
cord-350992-l6l24pco	26	30	viral	viral	JJ
cord-350992-l6l24pco	26	31	genome	genome	NN
cord-350992-l6l24pco	26	32	release	release	NN
cord-350992-l6l24pco	26	33	into	into	IN
cord-350992-l6l24pco	26	34	the	the	DT
cord-350992-l6l24pco	26	35	cytosol	cytosol	NN
cord-350992-l6l24pco	26	36	,	,	,
cord-350992-l6l24pco	26	37	as	as	IN
cord-350992-l6l24pco	26	38	observed	observe	VBN
cord-350992-l6l24pco	26	39	for	for	IN
cord-350992-l6l24pco	26	40	Sars	Sars	NNP
cord-350992-l6l24pco	26	41	-	-	HYPH
cord-350992-l6l24pco	26	42	Cov	Cov	NNP
cord-350992-l6l24pco	26	43	[	[	-LRB-
cord-350992-l6l24pco	26	44	18	18	CD
cord-350992-l6l24pco	26	45	]	]	-RRB-
cord-350992-l6l24pco	26	46	.	.	.
cord-350992-l6l24pco	27	1	[	[	-LRB-
cord-350992-l6l24pco	27	2	7	7	CD
cord-350992-l6l24pco	27	3	]	]	-RRB-
cord-350992-l6l24pco	27	4	.	.	.
cord-350992-l6l24pco	28	1	Cleavage	cleavage	NN
cord-350992-l6l24pco	28	2	sites	site	NNS
cord-350992-l6l24pco	28	3	other	other	JJ
cord-350992-l6l24pco	28	4	than	than	IN
cord-350992-l6l24pco	28	5	those	those	DT
cord-350992-l6l24pco	28	6	recognized	recognize	VBN
cord-350992-l6l24pco	28	7	by	by	IN
cord-350992-l6l24pco	28	8	cathepsin	cathepsin	NN
cord-350992-l6l24pco	28	9	and	and	CC
cord-350992-l6l24pco	28	10	TMPRSS2	TMPRSS2	NNP
cord-350992-l6l24pco	28	11	have	have	VBP
cord-350992-l6l24pco	28	12	been	be	VBN
cord-350992-l6l24pco	28	13	identified	identify	VBN
cord-350992-l6l24pco	28	14	in	in	IN
cord-350992-l6l24pco	28	15	the	the	DT
cord-350992-l6l24pco	28	16	S	S	NNP
cord-350992-l6l24pco	28	17	protein	protein	NN
cord-350992-l6l24pco	28	18	of	of	IN
cord-350992-l6l24pco	28	19	Sars	Sars	NNP
cord-350992-l6l24pco	29	1	-Cov-2	-Cov-2	:
cord-350992-l6l24pco	29	2	that	that	DT
cord-350992-l6l24pco	29	3	may	may	MD
cord-350992-l6l24pco	29	4	be	be	VB
cord-350992-l6l24pco	29	5	cleaved	cleave	VBN
cord-350992-l6l24pco	29	6	by	by	IN
cord-350992-l6l24pco	29	7	furin	furin	NN
cord-350992-l6l24pco	29	8	-	-	HYPH
cord-350992-l6l24pco	29	9	like	like	JJ
cord-350992-l6l24pco	29	10	proteases	protease	NNS
cord-350992-l6l24pco	29	11	.	.	.
cord-350992-l6l24pco	30	1	Furin	Furin	NNP
cord-350992-l6l24pco	30	2	is	be	VBZ
cord-350992-l6l24pco	30	3	localized	localize	VBN
cord-350992-l6l24pco	30	4	in	in	IN
cord-350992-l6l24pco	30	5	the	the	DT
cord-350992-l6l24pco	30	6	TGN	TGN	NNP
cord-350992-l6l24pco	30	7	,	,	,
cord-350992-l6l24pco	30	8	is	be	VBZ
cord-350992-l6l24pco	30	9	highly	highly	RB
cord-350992-l6l24pco	30	10	expressed	express	VBN
cord-350992-l6l24pco	30	11	in	in	IN
cord-350992-l6l24pco	30	12	the	the	DT
cord-350992-l6l24pco	30	13	lung	lung	NN
cord-350992-l6l24pco	30	14	,	,	,
cord-350992-l6l24pco	30	15	its	-PRON-	PRP$
cord-350992-l6l24pco	30	16	cleavage	cleavage	NN
cord-350992-l6l24pco	30	17	of	of	IN
cord-350992-l6l24pco	30	18	S	s	NN
cord-350992-l6l24pco	30	19	protein	protein	NN
cord-350992-l6l24pco	30	20	could	could	MD
cord-350992-l6l24pco	30	21	be	be	VB
cord-350992-l6l24pco	30	22	implicated	implicate	VBN
cord-350992-l6l24pco	30	23	in	in	IN
cord-350992-l6l24pco	30	24	virus	virus	NN
cord-350992-l6l24pco	30	25	egress	egress	NN
cord-350992-l6l24pco	30	26	and	and	CC
cord-350992-l6l24pco	30	27	spread	spread	VBD
cord-350992-l6l24pco	30	28	[	[	-LRB-
cord-350992-l6l24pco	30	29	19	19	CD
cord-350992-l6l24pco	30	30	]	]	-RRB-
cord-350992-l6l24pco	30	31	and	and	CC
cord-350992-l6l24pco	30	32	might	may	MD
cord-350992-l6l24pco	30	33	be	be	VB
cord-350992-l6l24pco	30	34	inhibited	inhibit	VBN
cord-350992-l6l24pco	30	35	by	by	IN
cord-350992-l6l24pco	30	36	CQ	CQ	NNP
cord-350992-l6l24pco	30	37	,	,	,
cord-350992-l6l24pco	30	38	as	as	IN
cord-350992-l6l24pco	30	39	observed	observe	VBN
cord-350992-l6l24pco	30	40	in	in	IN
cord-350992-l6l24pco	30	41	Chikungunya	Chikungunya	NNP
cord-350992-l6l24pco	30	42	virus	virus	NN
cord-350992-l6l24pco	30	43	infection	infection	NN
cord-350992-l6l24pco	30	44	[	[	-LRB-
cord-350992-l6l24pco	30	45	20	20	CD
cord-350992-l6l24pco	30	46	]	]	-RRB-
cord-350992-l6l24pco	30	47	.	.	.
cord-350992-l6l24pco	31	1	Due	due	IN
cord-350992-l6l24pco	31	2	to	to	IN
cord-350992-l6l24pco	31	3	their	-PRON-	PRP$
cord-350992-l6l24pco	31	4	basic	basic	JJ
cord-350992-l6l24pco	31	5	properties	property	NNS
cord-350992-l6l24pco	31	6	and	and	CC
cord-350992-l6l24pco	31	7	consequent	consequent	JJ
cord-350992-l6l24pco	31	8	disruption	disruption	NN
cord-350992-l6l24pco	31	9	of	of	IN
cord-350992-l6l24pco	31	10	cellular	cellular	JJ
cord-350992-l6l24pco	31	11	vesicle	vesicle	NN
cord-350992-l6l24pco	31	12	compartments	compartment	NNS
cord-350992-l6l24pco	31	13	,	,	,
cord-350992-l6l24pco	31	14	CQ	CQ	NNP
cord-350992-l6l24pco	31	15	/	/	SYM
cord-350992-l6l24pco	31	16	HCQ	HCQ	NNP
cord-350992-l6l24pco	31	17	may	may	MD
cord-350992-l6l24pco	31	18	also	also	RB
cord-350992-l6l24pco	31	19	inhibit	inhibit	VB
cord-350992-l6l24pco	31	20	virion	virion	NN
cord-350992-l6l24pco	31	21	budding	bud	VBG
cord-350992-l6l24pco	31	22	,	,	,
cord-350992-l6l24pco	31	23	occurring	occur	VBG
cord-350992-l6l24pco	31	24	when	when	WRB
cord-350992-l6l24pco	31	25	encapsidated	encapsidate	VBN
cord-350992-l6l24pco	31	26	viral	viral	JJ
cord-350992-l6l24pco	31	27	genomes	genome	NNS
cord-350992-l6l24pco	31	28	bud	bud	VBP
cord-350992-l6l24pco	31	29	into	into	IN
cord-350992-l6l24pco	31	30	the	the	DT
cord-350992-l6l24pco	31	31	ERGIC	ERGIC	NNP
cord-350992-l6l24pco	31	32	membranes	membrane	NNS
cord-350992-l6l24pco	31	33	in	in	IN
cord-350992-l6l24pco	31	34	which	which	WDT
cord-350992-l6l24pco	31	35	viral	viral	JJ
cord-350992-l6l24pco	31	36	envelope	envelope	NN
cord-350992-l6l24pco	31	37	proteins	protein	NNS
cord-350992-l6l24pco	31	38	are	be	VBP
cord-350992-l6l24pco	31	39	inserted	insert	VBN
cord-350992-l6l24pco	31	40	,	,	,
cord-350992-l6l24pco	31	41	forming	form	VBG
cord-350992-l6l24pco	31	42	mature	mature	JJ
cord-350992-l6l24pco	31	43	virions	virion	NNS
cord-350992-l6l24pco	31	44	[	[	-LRB-
cord-350992-l6l24pco	31	45	21	21	CD
cord-350992-l6l24pco	31	46	]	]	-RRB-
cord-350992-l6l24pco	31	47	.	.	.
cord-350992-l6l24pco	32	1	Within	within	IN
cord-350992-l6l24pco	32	2	infected	infected	JJ
cord-350992-l6l24pco	32	3	airway	airway	NN
cord-350992-l6l24pco	32	4	epithelium	epithelium	NN
cord-350992-l6l24pco	32	5	,	,	,
cord-350992-l6l24pco	32	6	through	through	IN
cord-350992-l6l24pco	32	7	their	-PRON-	PRP$
cord-350992-l6l24pco	32	8	binding	binding	NN
cord-350992-l6l24pco	32	9	to	to	IN
cord-350992-l6l24pco	32	10	Toll	toll	NN
cord-350992-l6l24pco	32	11	-	-	HYPH
cord-350992-l6l24pco	32	12	like	like	JJ
cord-350992-l6l24pco	32	13	receptors	receptor	NNS
cord-350992-l6l24pco	32	14	(	(	-LRB-
cord-350992-l6l24pco	32	15	TLRs	TLRs	NNP
cord-350992-l6l24pco	32	16	)	)	-RRB-
cord-350992-l6l24pco	32	17	,	,	,
cord-350992-l6l24pco	32	18	several	several	JJ
cord-350992-l6l24pco	32	19	respiratory	respiratory	JJ
cord-350992-l6l24pco	32	20	viruses	virus	NNS
cord-350992-l6l24pco	32	21	(	(	-LRB-
cord-350992-l6l24pco	32	22	among	among	IN
cord-350992-l6l24pco	32	23	them	-PRON-	PRP
cord-350992-l6l24pco	32	24	some	some	DT
cord-350992-l6l24pco	32	25	coronaviruses	coronaviruse	NNS
cord-350992-l6l24pco	32	26	)	)	-RRB-
cord-350992-l6l24pco	32	27	activate	activate	VBP
cord-350992-l6l24pco	32	28	the	the	DT
cord-350992-l6l24pco	32	29	mitogen	mitogen	NN
cord-350992-l6l24pco	32	30	-	-	HYPH
cord-350992-l6l24pco	32	31	activated	activate	VBN
cord-350992-l6l24pco	32	32	protein	protein	NN
cord-350992-l6l24pco	32	33	kinase	kinase	NN
cord-350992-l6l24pco	32	34	(	(	-LRB-
cord-350992-l6l24pco	32	35	MAPK	MAPK	NNP
cord-350992-l6l24pco	32	36	)	)	-RRB-
cord-350992-l6l24pco	32	37	pathways	pathway	NNS
cord-350992-l6l24pco	32	38	,	,	,
cord-350992-l6l24pco	32	39	particularly	particularly	RB
cord-350992-l6l24pco	32	40	the	the	DT
cord-350992-l6l24pco	32	41	p38	p38	JJ
cord-350992-l6l24pco	32	42	MAPK	MAPK	NNP
cord-350992-l6l24pco	32	43	.	.	.
cord-350992-l6l24pco	33	1	Respiratory	respiratory	JJ
cord-350992-l6l24pco	33	2	viruses	virus	NNS
cord-350992-l6l24pco	33	3	harness	harness	VBP
cord-350992-l6l24pco	33	4	MAPK	MAPK	NNP
cord-350992-l6l24pco	33	5	activation	activation	NN
cord-350992-l6l24pco	33	6	to	to	IN
cord-350992-l6l24pco	33	7	their	-PRON-	PRP$
cord-350992-l6l24pco	33	8	own	own	JJ
cord-350992-l6l24pco	33	9	advantage	advantage	NN
cord-350992-l6l24pco	33	10	,	,	,
cord-350992-l6l24pco	33	11	exploiting	exploit	VBG
cord-350992-l6l24pco	33	12	the	the	DT
cord-350992-l6l24pco	33	13	triggering	trigger	VBG
cord-350992-l6l24pco	33	14	of	of	IN
cord-350992-l6l24pco	33	15	their	-PRON-	PRP$
cord-350992-l6l24pco	33	16	downstream	downstream	JJ
cord-350992-l6l24pco	33	17	targets	target	NNS
cord-350992-l6l24pco	33	18	for	for	IN
cord-350992-l6l24pco	33	19	trafficking	traffic	VBG
cord-350992-l6l24pco	33	20	their	-PRON-	PRP$
cord-350992-l6l24pco	33	21	own	own	JJ
cord-350992-l6l24pco	33	22	proteins	protein	NNS
cord-350992-l6l24pco	33	23	and	and	CC
cord-350992-l6l24pco	33	24	for	for	IN
cord-350992-l6l24pco	33	25	viral	viral	JJ
cord-350992-l6l24pco	33	26	assembly	assembly	NN
cord-350992-l6l24pco	33	27	and	and	CC
cord-350992-l6l24pco	33	28	spread	spread	NN
cord-350992-l6l24pco	33	29	.	.	.
cord-350992-l6l24pco	34	1	These	these	DT
cord-350992-l6l24pco	34	2	effects	effect	NNS
cord-350992-l6l24pco	34	3	are	be	VBP
cord-350992-l6l24pco	34	4	particularly	particularly	RB
cord-350992-l6l24pco	34	5	important	important	JJ
cord-350992-l6l24pco	34	6	in	in	IN
cord-350992-l6l24pco	34	7	people	people	NNS
cord-350992-l6l24pco	34	8	suffering	suffer	VBG
cord-350992-l6l24pco	34	9	for	for	IN
cord-350992-l6l24pco	34	10	underlying	underlie	VBG
cord-350992-l6l24pco	34	11	airway	airway	NN
cord-350992-l6l24pco	34	12	diseases	disease	NNS
cord-350992-l6l24pco	34	13	,	,	,
cord-350992-l6l24pco	34	14	like	like	IN
cord-350992-l6l24pco	34	15	asthma	asthma	NN
cord-350992-l6l24pco	34	16	or	or	CC
cord-350992-l6l24pco	34	17	chronic	chronic	JJ
cord-350992-l6l24pco	34	18	obstructive	obstructive	JJ
cord-350992-l6l24pco	34	19	pulmonary	pulmonary	JJ
cord-350992-l6l24pco	34	20	disease	disease	NN
cord-350992-l6l24pco	34	21	(	(	-LRB-
cord-350992-l6l24pco	34	22	COPD	COPD	NNP
cord-350992-l6l24pco	34	23	)	)	-RRB-
cord-350992-l6l24pco	34	24	,	,	,
cord-350992-l6l24pco	34	25	who	who	WP
cord-350992-l6l24pco	34	26	undergo	undergo	VBP
cord-350992-l6l24pco	34	27	a	a	DT
cord-350992-l6l24pco	34	28	respiratory	respiratory	JJ
cord-350992-l6l24pco	34	29	viral	viral	JJ
cord-350992-l6l24pco	34	30	infection	infection	NN
cord-350992-l6l24pco	34	31	,	,	,
cord-350992-l6l24pco	34	32	since	since	IN
cord-350992-l6l24pco	34	33	these	these	DT
cord-350992-l6l24pco	34	34	pathways	pathway	NNS
cord-350992-l6l24pco	34	35	are	be	VBP
cord-350992-l6l24pco	34	36	already	already	RB
cord-350992-l6l24pco	34	37	turned	turn	VBN
cord-350992-l6l24pco	34	38	on	on	RP
cord-350992-l6l24pco	34	39	and	and	CC
cord-350992-l6l24pco	34	40	aberrantly	aberrantly	RB
cord-350992-l6l24pco	34	41	activated	activate	VBN
cord-350992-l6l24pco	34	42	[	[	-LRB-
cord-350992-l6l24pco	34	43	22	22	CD
cord-350992-l6l24pco	34	44	]	]	-RRB-
cord-350992-l6l24pco	34	45	.	.	.
cord-350992-l6l24pco	35	1	CQ	CQ	NNP
cord-350992-l6l24pco	35	2	has	have	VBZ
cord-350992-l6l24pco	35	3	been	be	VBN
cord-350992-l6l24pco	35	4	shown	show	VBN
cord-350992-l6l24pco	35	5	to	to	TO
cord-350992-l6l24pco	35	6	hinder	hinder	VB
cord-350992-l6l24pco	35	7	viral	viral	JJ
cord-350992-l6l24pco	35	8	infections	infection	NNS
cord-350992-l6l24pco	35	9	through	through	IN
cord-350992-l6l24pco	35	10	the	the	DT
cord-350992-l6l24pco	35	11	inhibition	inhibition	NN
cord-350992-l6l24pco	35	12	of	of	IN
cord-350992-l6l24pco	35	13	p38	p38	CD
cord-350992-l6l24pco	35	14	MAPK	MAPK	NNP
cord-350992-l6l24pco	35	15	activation	activation	NN
cord-350992-l6l24pco	35	16	[	[	-LRB-
cord-350992-l6l24pco	35	17	23	23	CD
cord-350992-l6l24pco	35	18	,	,	,
cord-350992-l6l24pco	35	19	24	24	CD
cord-350992-l6l24pco	35	20	]	]	-RRB-
cord-350992-l6l24pco	35	21	.	.	.
cord-350992-l6l24pco	36	1	This	this	DT
cord-350992-l6l24pco	36	2	inhibitory	inhibitory	JJ
cord-350992-l6l24pco	36	3	action	action	NN
cord-350992-l6l24pco	36	4	could	could	MD
cord-350992-l6l24pco	36	5	then	then	RB
cord-350992-l6l24pco	36	6	be	be	VB
cord-350992-l6l24pco	36	7	of	of	IN
cord-350992-l6l24pco	36	8	particular	particular	JJ
cord-350992-l6l24pco	36	9	importance	importance	NN
cord-350992-l6l24pco	36	10	in	in	IN
cord-350992-l6l24pco	36	11	COVID-19	COVID-19	NNP
cord-350992-l6l24pco	36	12	since	since	IN
cord-350992-l6l24pco	36	13	people	people	NNS
cord-350992-l6l24pco	36	14	with	with	IN
cord-350992-l6l24pco	36	15	COPD	COPD	NNP
cord-350992-l6l24pco	36	16	are	be	VBP
cord-350992-l6l24pco	36	17	among	among	IN
cord-350992-l6l24pco	36	18	the	the	DT
cord-350992-l6l24pco	36	19	worst	bad	JJS
cord-350992-l6l24pco	36	20	affected	affect	VBN
cord-350992-l6l24pco	36	21	by	by	IN
cord-350992-l6l24pco	36	22	Sars	Sars	NNP
cord-350992-l6l24pco	36	23	-	-	HYPH
cord-350992-l6l24pco	36	24	Cov-2	Cov-2	NNP
cord-350992-l6l24pco	36	25	infection	infection	NN
cord-350992-l6l24pco	36	26	.	.	.
cord-350992-l6l24pco	37	1	J	J	NNP
cord-350992-l6l24pco	37	2	o	o	NN
cord-350992-l6l24pco	37	3	u	u	NN
cord-350992-l6l24pco	37	4	r	r	NN
cord-350992-l6l24pco	37	5	n	n	NN
cord-350992-l6l24pco	37	6	a	a	DT
cord-350992-l6l24pco	37	7	l	l	NN
cord-350992-l6l24pco	37	8	P	p	NN
cord-350992-l6l24pco	37	9	r	r	NN
cord-350992-l6l24pco	37	10	e	e	NN
cord-350992-l6l24pco	37	11	-p	-p	NN
cord-350992-l6l24pco	38	1	r	r	LS
cord-350992-l6l24pco	39	1	o	o	UH
cord-350992-l6l24pco	40	1	o	o	UH
cord-350992-l6l24pco	40	2	f	f	NNP
cord-350992-l6l24pco	40	3	Therefore	therefore	RB
cord-350992-l6l24pco	40	4	,	,	,
cord-350992-l6l24pco	40	5	besides	besides	IN
cord-350992-l6l24pco	40	6	viral	viral	JJ
cord-350992-l6l24pco	40	7	attachment	attachment	NN
cord-350992-l6l24pco	40	8	and	and	CC
cord-350992-l6l24pco	40	9	entry	entry	NN
cord-350992-l6l24pco	40	10	,	,	,
cord-350992-l6l24pco	40	11	also	also	RB
cord-350992-l6l24pco	40	12	viral	viral	JJ
cord-350992-l6l24pco	40	13	uncoating	uncoating	NN
cord-350992-l6l24pco	40	14	,	,	,
cord-350992-l6l24pco	40	15	genome	genome	NN
cord-350992-l6l24pco	40	16	release	release	NN
cord-350992-l6l24pco	40	17	,	,	,
cord-350992-l6l24pco	40	18	protein	protein	NN
cord-350992-l6l24pco	40	19	maturation	maturation	NN
cord-350992-l6l24pco	40	20	process	process	NN
cord-350992-l6l24pco	40	21	and	and	CC
cord-350992-l6l24pco	40	22	assembly	assembly	NN
cord-350992-l6l24pco	40	23	of	of	IN
cord-350992-l6l24pco	40	24	new	new	JJ
cord-350992-l6l24pco	40	25	virions	virion	NNS
cord-350992-l6l24pco	40	26	for	for	IN
cord-350992-l6l24pco	40	27	budding	bud	VBG
cord-350992-l6l24pco	40	28	and	and	CC
cord-350992-l6l24pco	40	29	spread	spread	VB
cord-350992-l6l24pco	40	30	may	may	MD
cord-350992-l6l24pco	40	31	be	be	VB
cord-350992-l6l24pco	40	32	inhibited	inhibit	VBN
cord-350992-l6l24pco	40	33	by	by	IN
cord-350992-l6l24pco	40	34	the	the	DT
cord-350992-l6l24pco	40	35	basic	basic	JJ
cord-350992-l6l24pco	40	36	drugs	drug	NNS
cord-350992-l6l24pco	40	37	,	,	,
cord-350992-l6l24pco	40	38	resulting	result	VBG
cord-350992-l6l24pco	40	39	in	in	IN
cord-350992-l6l24pco	40	40	reduced	reduce	VBN
cord-350992-l6l24pco	40	41	infectivity	infectivity	NN
cord-350992-l6l24pco	40	42	.	.	.
cord-350992-l6l24pco	41	1	Little	little	JJ
cord-350992-l6l24pco	41	2	is	be	VBZ
cord-350992-l6l24pco	41	3	currently	currently	RB
cord-350992-l6l24pco	41	4	known	know	VBN
cord-350992-l6l24pco	41	5	about	about	IN
cord-350992-l6l24pco	41	6	the	the	DT
cord-350992-l6l24pco	41	7	mechanism(s	mechanism(s	NNP
cord-350992-l6l24pco	41	8	)	)	-RRB-
cord-350992-l6l24pco	41	9	of	of	IN
cord-350992-l6l24pco	41	10	action	action	NN
cord-350992-l6l24pco	41	11	of	of	IN
cord-350992-l6l24pco	41	12	CQ	CQ	NNP
cord-350992-l6l24pco	41	13	/	/	SYM
cord-350992-l6l24pco	41	14	HCQ	HCQ	NNP
cord-350992-l6l24pco	41	15	in	in	IN
cord-350992-l6l24pco	41	16	the	the	DT
cord-350992-l6l24pco	41	17	treatment	treatment	NN
cord-350992-l6l24pco	41	18	of	of	IN
cord-350992-l6l24pco	41	19	Sars	Sars	NNP
cord-350992-l6l24pco	41	20	-	-	HYPH
cord-350992-l6l24pco	41	21	Cov-2	Cov-2	NNP
cord-350992-l6l24pco	41	22	infection	infection	NN
cord-350992-l6l24pco	41	23	.	.	.
cord-350992-l6l24pco	42	1	The	the	DT
cord-350992-l6l24pco	42	2	first	first	JJ
cord-350992-l6l24pco	42	3	published	publish	VBN
cord-350992-l6l24pco	42	4	experimental	experimental	JJ
cord-350992-l6l24pco	42	5	evidence	evidence	NN
cord-350992-l6l24pco	42	6	of	of	IN
cord-350992-l6l24pco	42	7	the	the	DT
cord-350992-l6l24pco	42	8	potential	potential	JJ
cord-350992-l6l24pco	42	9	efficacy	efficacy	NN
cord-350992-l6l24pco	42	10	of	of	IN
cord-350992-l6l24pco	42	11	CQ	CQ	NNP
cord-350992-l6l24pco	42	12	/	/	SYM
cord-350992-l6l24pco	42	13	HCQ	HCQ	NNP
cord-350992-l6l24pco	42	14	in	in	IN
cord-350992-l6l24pco	42	15	this	this	DT
cord-350992-l6l24pco	42	16	disease	disease	NN
cord-350992-l6l24pco	42	17	comes	come	VBZ
cord-350992-l6l24pco	42	18	from	from	IN
cord-350992-l6l24pco	42	19	in	in	IN
cord-350992-l6l24pco	42	20	vitro	vitro	FW
cord-350992-l6l24pco	42	21	experiments	experiment	NNS
cord-350992-l6l24pco	42	22	.	.	.
cord-350992-l6l24pco	43	1	Wang	Wang	NNP
cord-350992-l6l24pco	43	2	and	and	CC
cord-350992-l6l24pco	43	3	colleagues	colleague	NNS
cord-350992-l6l24pco	43	4	[	[	-LRB-
cord-350992-l6l24pco	43	5	8	8	CD
cord-350992-l6l24pco	43	6	]	]	-RRB-
cord-350992-l6l24pco	43	7	results	result	NNS
cord-350992-l6l24pco	43	8	suggested	suggest	VBD
cord-350992-l6l24pco	43	9	that	that	IN
cord-350992-l6l24pco	43	10	CQ	CQ	NNP
cord-350992-l6l24pco	43	11	could	could	MD
cord-350992-l6l24pco	43	12	be	be	VB
cord-350992-l6l24pco	43	13	more	more	RBR
cord-350992-l6l24pco	43	14	efficacious	efficacious	JJ
cord-350992-l6l24pco	43	15	than	than	IN
cord-350992-l6l24pco	43	16	HCQ	HCQ	NNP
cord-350992-l6l24pco	43	17	.	.	.
cord-350992-l6l24pco	44	1	The	the	DT
cord-350992-l6l24pco	44	2	authors	author	NNS
cord-350992-l6l24pco	44	3	also	also	RB
cord-350992-l6l24pco	44	4	confirmed	confirm	VBD
cord-350992-l6l24pco	44	5	that	that	IN
cord-350992-l6l24pco	44	6	CQ	CQ	NNP
cord-350992-l6l24pco	44	7	acts	act	VBZ
cord-350992-l6l24pco	44	8	at	at	IN
cord-350992-l6l24pco	44	9	both	both	DT
cord-350992-l6l24pco	44	10	entry	entry	NN
cord-350992-l6l24pco	44	11	and	and	CC
cord-350992-l6l24pco	44	12	post	post	JJ
cord-350992-l6l24pco	44	13	-	-	JJ
cord-350992-l6l24pco	44	14	entry	entry	JJ
cord-350992-l6l24pco	44	15	stages	stage	NNS
cord-350992-l6l24pco	44	16	and	and	CC
cord-350992-l6l24pco	44	17	this	this	DT
cord-350992-l6l24pco	44	18	double	double	JJ
cord-350992-l6l24pco	44	19	action	action	NN
cord-350992-l6l24pco	44	20	was	be	VBD
cord-350992-l6l24pco	44	21	also	also	RB
cord-350992-l6l24pco	44	22	observed	observe	VBN
cord-350992-l6l24pco	44	23	for	for	IN
cord-350992-l6l24pco	44	24	HCQ	HCQ	NNP
cord-350992-l6l24pco	44	25	.	.	.
cord-350992-l6l24pco	45	1	In	in	IN
cord-350992-l6l24pco	45	2	order	order	NN
cord-350992-l6l24pco	45	3	to	to	TO
cord-350992-l6l24pco	45	4	shed	shed	VB
cord-350992-l6l24pco	45	5	light	light	NN
cord-350992-l6l24pco	45	6	on	on	IN
cord-350992-l6l24pco	45	7	potential	potential	JJ
cord-350992-l6l24pco	45	8	mechanisms	mechanism	NNS
cord-350992-l6l24pco	45	9	of	of	IN
cord-350992-l6l24pco	45	10	action	action	NN
cord-350992-l6l24pco	45	11	of	of	IN
cord-350992-l6l24pco	45	12	the	the	DT
cord-350992-l6l24pco	45	13	drugs	drug	NNS
cord-350992-l6l24pco	45	14	,	,	,
cord-350992-l6l24pco	45	15	the	the	DT
cord-350992-l6l24pco	45	16	authors	author	NNS
cord-350992-l6l24pco	45	17	studied	study	VBD
cord-350992-l6l24pco	45	18	the	the	DT
cord-350992-l6l24pco	45	19	cellular	cellular	JJ
cord-350992-l6l24pco	45	20	localization	localization	NN
cord-350992-l6l24pco	45	21	of	of	IN
cord-350992-l6l24pco	45	22	viral	viral	JJ
cord-350992-l6l24pco	45	23	particles	particle	NNS
cord-350992-l6l24pco	45	24	and	and	CC
cord-350992-l6l24pco	45	25	found	find	VBD
cord-350992-l6l24pco	45	26	virions	virion	NNS
cord-350992-l6l24pco	45	27	partly	partly	RB
cord-350992-l6l24pco	45	28	in	in	IN
cord-350992-l6l24pco	45	29	early	early	JJ
cord-350992-l6l24pco	45	30	endosomes	endosome	NNS
cord-350992-l6l24pco	45	31	(	(	-LRB-
cord-350992-l6l24pco	45	32	EEs	ees	UH
cord-350992-l6l24pco	45	33	)	)	-RRB-
cord-350992-l6l24pco	45	34	and	and	CC
cord-350992-l6l24pco	45	35	more	more	JJR
cord-350992-l6l24pco	45	36	in	in	IN
cord-350992-l6l24pco	45	37	late	late	JJ
cord-350992-l6l24pco	45	38	endosome	endosome	NN
cord-350992-l6l24pco	45	39	-	-	HYPH
cord-350992-l6l24pco	45	40	lysosomes	lysosome	NNS
cord-350992-l6l24pco	45	41	(	(	-LRB-
cord-350992-l6l24pco	45	42	LELs	lel	NNS
cord-350992-l6l24pco	45	43	)	)	-RRB-
cord-350992-l6l24pco	45	44	in	in	IN
cord-350992-l6l24pco	45	45	control	control	NN
cord-350992-l6l24pco	45	46	conditions	condition	NNS
cord-350992-l6l24pco	45	47	.	.	.
cord-350992-l6l24pco	46	1	When	when	WRB
cord-350992-l6l24pco	46	2	cells	cell	NNS
cord-350992-l6l24pco	46	3	were	be	VBD
cord-350992-l6l24pco	46	4	treated	treat	VBN
cord-350992-l6l24pco	46	5	with	with	IN
cord-350992-l6l24pco	46	6	CQ	CQ	NNP
cord-350992-l6l24pco	46	7	and	and	CC
cord-350992-l6l24pco	46	8	HCQ	HCQ	NNP
cord-350992-l6l24pco	46	9	,	,	,
cord-350992-l6l24pco	46	10	more	more	RBR
cord-350992-l6l24pco	46	11	viral	viral	JJ
cord-350992-l6l24pco	46	12	particles	particle	NNS
cord-350992-l6l24pco	46	13	were	be	VBD
cord-350992-l6l24pco	46	14	observed	observe	VBN
cord-350992-l6l24pco	46	15	in	in	IN
cord-350992-l6l24pco	46	16	EEs	EEs	NNP
cord-350992-l6l24pco	46	17	,	,	,
cord-350992-l6l24pco	46	18	suggesting	suggest	VBG
cord-350992-l6l24pco	46	19	that	that	IN
cord-350992-l6l24pco	46	20	the	the	DT
cord-350992-l6l24pco	46	21	drugs	drug	NNS
cord-350992-l6l24pco	46	22	block	block	VBP
cord-350992-l6l24pco	46	23	endocytotic	endocytotic	JJ
cord-350992-l6l24pco	46	24	vesicle	vesicle	NN
cord-350992-l6l24pco	46	25	maturation	maturation	NN
cord-350992-l6l24pco	46	26	at	at	IN
cord-350992-l6l24pco	46	27	intermediate	intermediate	JJ
cord-350992-l6l24pco	46	28	stages	stage	NNS
cord-350992-l6l24pco	46	29	and	and	CC
cord-350992-l6l24pco	46	30	probably	probably	RB
cord-350992-l6l24pco	46	31	stall	stall	VB
cord-350992-l6l24pco	46	32	the	the	DT
cord-350992-l6l24pco	46	33	virus	virus	NN
cord-350992-l6l24pco	46	34	transport	transport	NN
cord-350992-l6l24pco	46	35	from	from	IN
cord-350992-l6l24pco	46	36	EEs	EEs	NNP
cord-350992-l6l24pco	46	37	to	to	IN
cord-350992-l6l24pco	46	38	LELs	lel	NNS
cord-350992-l6l24pco	46	39	,	,	,
cord-350992-l6l24pco	46	40	a	a	DT
cord-350992-l6l24pco	46	41	crucial	crucial	JJ
cord-350992-l6l24pco	46	42	step	step	NN
cord-350992-l6l24pco	46	43	for	for	IN
cord-350992-l6l24pco	46	44	the	the	DT
cord-350992-l6l24pco	46	45	release	release	NN
cord-350992-l6l24pco	46	46	of	of	IN
cord-350992-l6l24pco	46	47	viral	viral	JJ
cord-350992-l6l24pco	46	48	genome	genome	NN
cord-350992-l6l24pco	46	49	.	.	.
cord-350992-l6l24pco	47	1	The	the	DT
cord-350992-l6l24pco	47	2	authors	author	NNS
cord-350992-l6l24pco	47	3	also	also	RB
cord-350992-l6l24pco	47	4	observed	observe	VBD
cord-350992-l6l24pco	47	5	that	that	IN
cord-350992-l6l24pco	47	6	both	both	DT
cord-350992-l6l24pco	47	7	CQ	CQ	NNP
cord-350992-l6l24pco	47	8	and	and	CC
cord-350992-l6l24pco	47	9	HCQ	HCQ	NNP
cord-350992-l6l24pco	47	10	treatments	treatment	NNS
cord-350992-l6l24pco	47	11	resulted	result	VBD
cord-350992-l6l24pco	47	12	in	in	IN
cord-350992-l6l24pco	47	13	abnormally	abnormally	RB
cord-350992-l6l24pco	47	14	enlarged	enlarged	JJ
cord-350992-l6l24pco	47	15	EEs	ee	NNS
cord-350992-l6l24pco	47	16	,	,	,
cord-350992-l6l24pco	47	17	but	but	CC
cord-350992-l6l24pco	47	18	while	while	IN
cord-350992-l6l24pco	47	19	HCQ	HCQ	NNP
cord-350992-l6l24pco	47	20	increased	increase	VBD
cord-350992-l6l24pco	47	21	LEL	LEL	NNP
cord-350992-l6l24pco	47	22	size	size	NN
cord-350992-l6l24pco	47	23	and	and	CC
cord-350992-l6l24pco	47	24	number	number	NN
cord-350992-l6l24pco	47	25	,	,	,
cord-350992-l6l24pco	47	26	CQ	CQ	NNP
cord-350992-l6l24pco	47	27	treatment	treatment	NN
cord-350992-l6l24pco	47	28	induced	induce	VBD
cord-350992-l6l24pco	47	29	no	no	DT
cord-350992-l6l24pco	47	30	changes	change	NNS
cord-350992-l6l24pco	47	31	in	in	IN
cord-350992-l6l24pco	47	32	number	number	NN
cord-350992-l6l24pco	47	33	and	and	CC
cord-350992-l6l24pco	47	34	size	size	NN
cord-350992-l6l24pco	47	35	of	of	IN
cord-350992-l6l24pco	47	36	LELs	lel	NNS
cord-350992-l6l24pco	47	37	but	but	CC
cord-350992-l6l24pco	47	38	the	the	DT
cord-350992-l6l24pco	47	39	vesicle	vesicle	NN
cord-350992-l6l24pco	47	40	structure	structure	NN
cord-350992-l6l24pco	47	41	was	be	VBD
cord-350992-l6l24pco	47	42	disrupted	disrupt	VBN
cord-350992-l6l24pco	47	43	,	,	,
cord-350992-l6l24pco	47	44	suggesting	suggest	VBG
cord-350992-l6l24pco	47	45	partially	partially	RB
cord-350992-l6l24pco	47	46	distinct	distinct	JJ
cord-350992-l6l24pco	47	47	mechanisms	mechanism	NNS
cord-350992-l6l24pco	47	48	of	of	IN
cord-350992-l6l24pco	47	49	action	action	NN
cord-350992-l6l24pco	47	50	of	of	IN
cord-350992-l6l24pco	47	51	the	the	DT
cord-350992-l6l24pco	47	52	two	two	CD
cord-350992-l6l24pco	47	53	drugs	drug	NNS
cord-350992-l6l24pco	47	54	.	.	.
cord-350992-l6l24pco	48	1	The	the	DT
cord-350992-l6l24pco	48	2	anti	anti	JJ
cord-350992-l6l24pco	48	3	-	-	JJ
cord-350992-l6l24pco	48	4	Sars	Sars	NNP
cord-350992-l6l24pco	48	5	-	-	HYPH
cord-350992-l6l24pco	48	6	Cov-2	Cov-2	NNP
cord-350992-l6l24pco	48	7	in	in	IN
cord-350992-l6l24pco	48	8	vitro	vitro	FW
cord-350992-l6l24pco	48	9	action	action	NN
cord-350992-l6l24pco	48	10	of	of	IN
cord-350992-l6l24pco	48	11	CQ	CQ	NNP
cord-350992-l6l24pco	48	12	and	and	CC
cord-350992-l6l24pco	48	13	HCQ	HCQ	NNP
cord-350992-l6l24pco	48	14	was	be	VBD
cord-350992-l6l24pco	48	15	confirmed	confirm	VBN
cord-350992-l6l24pco	48	16	in	in	IN
cord-350992-l6l24pco	48	17	the	the	DT
cord-350992-l6l24pco	48	18	same	same	JJ
cord-350992-l6l24pco	48	19	cellular	cellular	JJ
cord-350992-l6l24pco	48	20	model	model	NN
cord-350992-l6l24pco	48	21	by	by	IN
cord-350992-l6l24pco	48	22	[	[	-LRB-
cord-350992-l6l24pco	48	23	10	10	CD
cord-350992-l6l24pco	48	24	]	]	-RRB-
cord-350992-l6l24pco	48	25	.	.	.
cord-350992-l6l24pco	49	1	These	these	DT
cord-350992-l6l24pco	49	2	authors	author	NNS
cord-350992-l6l24pco	49	3	found	find	VBD
cord-350992-l6l24pco	49	4	EC	EC	NNP
cord-350992-l6l24pco	49	5	50	50	CD
cord-350992-l6l24pco	49	6	values	value	NNS
cord-350992-l6l24pco	49	7	of	of	IN
cord-350992-l6l24pco	49	8	23.90	23.90	CD
cord-350992-l6l24pco	49	9	and	and	CC
cord-350992-l6l24pco	49	10	5.47	5.47	CD
cord-350992-l6l24pco	49	11	for	for	IN
cord-350992-l6l24pco	49	12	CQ	CQ	NNP
cord-350992-l6l24pco	49	13	and	and	CC
cord-350992-l6l24pco	49	14	6.14	6.14	CD
cord-350992-l6l24pco	49	15	and	and	CC
cord-350992-l6l24pco	49	16	0.72	0.72	CD
cord-350992-l6l24pco	49	17	mM	mm	CD
cord-350992-l6l24pco	49	18	at	at	IN
cord-350992-l6l24pco	49	19	24	24	CD
cord-350992-l6l24pco	49	20	and	and	CC
cord-350992-l6l24pco	49	21	48h	48h	NNS
cord-350992-l6l24pco	49	22	for	for	IN
cord-350992-l6l24pco	49	23	CQ	CQ	NNP
cord-350992-l6l24pco	49	24	and	and	CC
cord-350992-l6l24pco	49	25	HCQ	HCQ	NNP
cord-350992-l6l24pco	49	26	respectively	respectively	RB
cord-350992-l6l24pco	49	27	,	,	,
cord-350992-l6l24pco	49	28	that	that	IN
cord-350992-l6l24pco	49	29	,	,	,
cord-350992-l6l24pco	49	30	in	in	IN
cord-350992-l6l24pco	49	31	contrast	contrast	NN
cord-350992-l6l24pco	49	32	with	with	IN
cord-350992-l6l24pco	49	33	the	the	DT
cord-350992-l6l24pco	49	34	previous	previous	JJ
cord-350992-l6l24pco	49	35	report	report	NN
cord-350992-l6l24pco	49	36	,	,	,
cord-350992-l6l24pco	49	37	was	be	VBD
cord-350992-l6l24pco	49	38	a	a	DT
cord-350992-l6l24pco	49	39	better	well	JJR
cord-350992-l6l24pco	49	40	performance	performance	NN
cord-350992-l6l24pco	49	41	for	for	IN
cord-350992-l6l24pco	49	42	HCQ	HCQ	NNP
cord-350992-l6l24pco	49	43	.	.	.
cord-350992-l6l24pco	50	1	They	-PRON-	PRP
cord-350992-l6l24pco	50	2	also	also	RB
cord-350992-l6l24pco	50	3	confirmed	confirm	VBD
cord-350992-l6l24pco	50	4	that	that	IN
cord-350992-l6l24pco	50	5	the	the	DT
cord-350992-l6l24pco	50	6	drugs	drug	NNS
cord-350992-l6l24pco	50	7	have	have	VBP
cord-350992-l6l24pco	50	8	anti	anti	JJ
cord-350992-l6l24pco	50	9	-	-	JJ
cord-350992-l6l24pco	50	10	viral	viral	JJ
cord-350992-l6l24pco	50	11	activity	activity	NN
cord-350992-l6l24pco	50	12	also	also	RB
cord-350992-l6l24pco	50	13	when	when	WRB
cord-350992-l6l24pco	50	14	administered	administer	VBN
cord-350992-l6l24pco	50	15	prior	prior	RB
cord-350992-l6l24pco	50	16	to	to	IN
cord-350992-l6l24pco	50	17	viral	viral	JJ
cord-350992-l6l24pco	50	18	infection	infection	NN
cord-350992-l6l24pco	50	19	,	,	,
cord-350992-l6l24pco	50	20	with	with	IN
cord-350992-l6l24pco	50	21	EC	EC	NNP
cord-350992-l6l24pco	50	22	50	50	CD
cord-350992-l6l24pco	50	23	values	value	NNS
cord-350992-l6l24pco	50	24	of	of	IN
cord-350992-l6l24pco	50	25	>	>	XX
cord-350992-l6l24pco	50	26	100	100	CD
cord-350992-l6l24pco	50	27	,	,	,
cord-350992-l6l24pco	50	28	and	and	CC
cord-350992-l6l24pco	50	29	18.01	18.01	CD
cord-350992-l6l24pco	50	30	for	for	IN
cord-350992-l6l24pco	50	31	CQ	CQ	NNP
cord-350992-l6l24pco	50	32	and	and	CC
cord-350992-l6l24pco	50	33	6.25	6.25	CD
cord-350992-l6l24pco	50	34	and	and	CC
cord-350992-l6l24pco	50	35	5.85	5.85	CD
cord-350992-l6l24pco	50	36	mM	mm	CD
cord-350992-l6l24pco	50	37	for	for	IN
cord-350992-l6l24pco	50	38	HCQ	HCQ	NNP
cord-350992-l6l24pco	50	39	respectively	respectively	RB
cord-350992-l6l24pco	50	40	at	at	IN
cord-350992-l6l24pco	50	41	24	24	CD
cord-350992-l6l24pco	50	42	and	and	CC
cord-350992-l6l24pco	50	43	48h	48h	NNS
cord-350992-l6l24pco	50	44	.	.	.
cord-350992-l6l24pco	51	1	CQ	CQ	NNP
cord-350992-l6l24pco	51	2	/	/	SYM
cord-350992-l6l24pco	51	3	HCQ	HCQ	NNP
cord-350992-l6l24pco	51	4	are	be	VBP
cord-350992-l6l24pco	51	5	also	also	RB
cord-350992-l6l24pco	51	6	used	use	VBN
cord-350992-l6l24pco	51	7	as	as	IN
cord-350992-l6l24pco	51	8	anti	anti	JJ
cord-350992-l6l24pco	51	9	-	-	JJ
cord-350992-l6l24pco	51	10	inflammatory	inflammatory	JJ
cord-350992-l6l24pco	51	11	and	and	CC
cord-350992-l6l24pco	51	12	immunomodulatory	immunomodulatory	JJ
cord-350992-l6l24pco	51	13	drugs	drug	NNS
cord-350992-l6l24pco	51	14	in	in	IN
cord-350992-l6l24pco	51	15	autoimmune	autoimmune	JJ
cord-350992-l6l24pco	51	16	diseases	disease	NNS
cord-350992-l6l24pco	51	17	,	,	,
cord-350992-l6l24pco	51	18	like	like	IN
cord-350992-l6l24pco	51	19	RA	RA	NNP
cord-350992-l6l24pco	51	20	and	and	CC
cord-350992-l6l24pco	51	21	SLE	SLE	NNP
cord-350992-l6l24pco	51	22	.	.	.
cord-350992-l6l24pco	52	1	These	these	DT
cord-350992-l6l24pco	52	2	properties	property	NNS
cord-350992-l6l24pco	52	3	derive	derive	VBP
cord-350992-l6l24pco	52	4	from	from	IN
cord-350992-l6l24pco	52	5	their	-PRON-	PRP$
cord-350992-l6l24pco	52	6	multiple	multiple	JJ
cord-350992-l6l24pco	52	7	effects	effect	NNS
cord-350992-l6l24pco	52	8	on	on	IN
cord-350992-l6l24pco	52	9	the	the	DT
cord-350992-l6l24pco	52	10	immune	immune	JJ
cord-350992-l6l24pco	52	11	system	system	NN
cord-350992-l6l24pco	52	12	cells	cell	NNS
cord-350992-l6l24pco	52	13	and	and	CC
cord-350992-l6l24pco	52	14	their	-PRON-	PRP$
cord-350992-l6l24pco	52	15	modulation	modulation	NN
cord-350992-l6l24pco	52	16	of	of	IN
cord-350992-l6l24pco	52	17	crucial	crucial	JJ
cord-350992-l6l24pco	52	18	pro	pro	JJ
cord-350992-l6l24pco	52	19	-	-	JJ
cord-350992-l6l24pco	52	20	inflammatory	inflammatory	JJ
cord-350992-l6l24pco	52	21	cytokines	cytokine	NNS
cord-350992-l6l24pco	52	22	[	[	-LRB-
cord-350992-l6l24pco	52	23	25	25	CD
cord-350992-l6l24pco	52	24	,	,	,
cord-350992-l6l24pco	52	25	26	26	CD
cord-350992-l6l24pco	52	26	]	]	-RRB-
cord-350992-l6l24pco	52	27	.	.	.
cord-350992-l6l24pco	53	1	See	see	VB
cord-350992-l6l24pco	53	2	Table	table	NN
cord-350992-l6l24pco	53	3	2	2	CD
cord-350992-l6l24pco	53	4	for	for	IN
cord-350992-l6l24pco	53	5	a	a	DT
cord-350992-l6l24pco	53	6	schematic	schematic	JJ
cord-350992-l6l24pco	53	7	list	list	NN
cord-350992-l6l24pco	53	8	of	of	IN
cord-350992-l6l24pco	53	9	CQ	CQ	NNP
cord-350992-l6l24pco	53	10	/	/	SYM
cord-350992-l6l24pco	53	11	HCQ	HCQ	NNP
cord-350992-l6l24pco	53	12	biological	biological	JJ
cord-350992-l6l24pco	53	13	activities	activity	NNS
cord-350992-l6l24pco	53	14	as	as	IN
cord-350992-l6l24pco	53	15	anti	anti	JJ
cord-350992-l6l24pco	53	16	-	-	JJ
cord-350992-l6l24pco	53	17	inflammatory	inflammatory	JJ
cord-350992-l6l24pco	53	18	drugs	drug	NNS
cord-350992-l6l24pco	53	19	.	.	.
cord-350992-l6l24pco	54	1	CQ	CQ	NNP
cord-350992-l6l24pco	54	2	/	/	SYM
cord-350992-l6l24pco	54	3	HCQ	HCQ	NNP
cord-350992-l6l24pco	54	4	may	may	MD
cord-350992-l6l24pco	54	5	impair	impair	VB
cord-350992-l6l24pco	54	6	the	the	DT
cord-350992-l6l24pco	54	7	correct	correct	JJ
cord-350992-l6l24pco	54	8	maturation	maturation	NN
cord-350992-l6l24pco	54	9	and	and	CC
cord-350992-l6l24pco	54	10	recognition	recognition	NN
cord-350992-l6l24pco	54	11	of	of	IN
cord-350992-l6l24pco	54	12	viral	viral	JJ
cord-350992-l6l24pco	54	13	antigens	antigen	NNS
cord-350992-l6l24pco	54	14	by	by	IN
cord-350992-l6l24pco	54	15	antigen	antigen	NN
cord-350992-l6l24pco	54	16	-	-	HYPH
cord-350992-l6l24pco	54	17	presenting	present	VBG
cord-350992-l6l24pco	54	18	cells	cell	NNS
cord-350992-l6l24pco	54	19	(	(	-LRB-
cord-350992-l6l24pco	54	20	APCs	apc	NNS
cord-350992-l6l24pco	54	21	)	)	-RRB-
cord-350992-l6l24pco	54	22	that	that	WDT
cord-350992-l6l24pco	54	23	require	require	VBP
cord-350992-l6l24pco	54	24	endosomal	endosomal	JJ
cord-350992-l6l24pco	54	25	acidification	acidification	NN
cord-350992-l6l24pco	54	26	for	for	IN
cord-350992-l6l24pco	54	27	antigen	antigen	NN
cord-350992-l6l24pco	54	28	processing	processing	NN
cord-350992-l6l24pco	54	29	.	.	.
cord-350992-l6l24pco	55	1	By	by	IN
cord-350992-l6l24pco	55	2	phagocytosis	phagocytosis	NN
cord-350992-l6l24pco	55	3	and	and	CC
cord-350992-l6l24pco	55	4	macropynocytosis	macropynocytosis	NN
cord-350992-l6l24pco	55	5	,	,	,
cord-350992-l6l24pco	55	6	dendritic	dendritic	JJ
cord-350992-l6l24pco	55	7	cells	cell	NNS
cord-350992-l6l24pco	55	8	(	(	-LRB-
cord-350992-l6l24pco	55	9	DCs	DCs	NNP
cord-350992-l6l24pco	55	10	)	)	-RRB-
cord-350992-l6l24pco	55	11	capture	capture	NN
cord-350992-l6l24pco	55	12	pathogens	pathogen	NNS
cord-350992-l6l24pco	55	13	,	,	,
cord-350992-l6l24pco	55	14	process	process	NN
cord-350992-l6l24pco	55	15	and	and	CC
cord-350992-l6l24pco	55	16	present	present	VB
cord-350992-l6l24pco	55	17	their	-PRON-	PRP$
cord-350992-l6l24pco	55	18	antigens	antigen	NNS
cord-350992-l6l24pco	55	19	to	to	TO
cord-350992-l6l24pco	55	20	activate	activate	VB
cord-350992-l6l24pco	55	21	T	T	NNP
cord-350992-l6l24pco	55	22	cells	cell	NNS
cord-350992-l6l24pco	55	23	.	.	.
cord-350992-l6l24pco	56	1	Through	through	IN
cord-350992-l6l24pco	56	2	their	-PRON-	PRP$
cord-350992-l6l24pco	56	3	antigen	antigen	NN
cord-350992-l6l24pco	56	4	-	-	HYPH
cord-350992-l6l24pco	56	5	specific	specific	JJ
cord-350992-l6l24pco	56	6	B	b	NN
cord-350992-l6l24pco	56	7	cell	cell	NN
cord-350992-l6l24pco	56	8	receptor	receptor	NN
cord-350992-l6l24pco	56	9	and	and	CC
cord-350992-l6l24pco	56	10	CME	CME	NNP
cord-350992-l6l24pco	56	11	and	and	CC
cord-350992-l6l24pco	56	12	clathrin	clathrin	NN
cord-350992-l6l24pco	56	13	-	-	HYPH
cord-350992-l6l24pco	56	14	independent	independent	JJ
cord-350992-l6l24pco	56	15	endocytosis	endocytosis	NN
cord-350992-l6l24pco	56	16	,	,	,
cord-350992-l6l24pco	56	17	B	b	NN
cord-350992-l6l24pco	56	18	cells	cell	NNS
cord-350992-l6l24pco	56	19	recognize	recognize	VBP
cord-350992-l6l24pco	56	20	specific	specific	JJ
cord-350992-l6l24pco	56	21	antigens	antigen	NNS
cord-350992-l6l24pco	56	22	and	and	CC
cord-350992-l6l24pco	56	23	present	present	VB
cord-350992-l6l24pco	56	24	their	-PRON-	PRP$
cord-350992-l6l24pco	56	25	peptides	peptide	NNS
cord-350992-l6l24pco	56	26	to	to	TO
cord-350992-l6l24pco	56	27	specific	specific	VB
cord-350992-l6l24pco	56	28	T	t	NN
cord-350992-l6l24pco	56	29	cells	cell	NNS
cord-350992-l6l24pco	56	30	.	.	.
cord-350992-l6l24pco	57	1	Through	through	IN
cord-350992-l6l24pco	57	2	phagocytosis	phagocytosis	NN
cord-350992-l6l24pco	57	3	,	,	,
cord-350992-l6l24pco	57	4	CME	CME	NNP
cord-350992-l6l24pco	57	5	,	,	,
cord-350992-l6l24pco	57	6	caveolin	caveolin	NN
cord-350992-l6l24pco	57	7	-	-	HYPH
cord-350992-l6l24pco	57	8	mediated	mediate	VBN
cord-350992-l6l24pco	57	9	endocytosis	endocytosis	NN
cord-350992-l6l24pco	57	10	and	and	CC
cord-350992-l6l24pco	57	11	macropinocytosis	macropinocytosis	NN
cord-350992-l6l24pco	57	12	,	,	,
cord-350992-l6l24pco	57	13	macrophages	macrophage	NNS
cord-350992-l6l24pco	57	14	internalize	internalize	VBP
cord-350992-l6l24pco	57	15	pathogens	pathogen	NNS
cord-350992-l6l24pco	57	16	,	,	,
cord-350992-l6l24pco	57	17	process	process	VBP
cord-350992-l6l24pco	57	18	their	-PRON-	PRP$
cord-350992-l6l24pco	57	19	proteins	protein	NNS
cord-350992-l6l24pco	57	20	and	and	CC
cord-350992-l6l24pco	57	21	present	present	JJ
cord-350992-l6l24pco	57	22	antigens	antigen	NNS
cord-350992-l6l24pco	57	23	to	to	IN
cord-350992-l6l24pco	57	24	T	t	NN
cord-350992-l6l24pco	57	25	cells	cell	NNS
cord-350992-l6l24pco	57	26	.	.	.
cord-350992-l6l24pco	58	1	T	T	NNP
cord-350992-l6l24pco	58	2	cells	cell	NNS
cord-350992-l6l24pco	58	3	,	,	,
cord-350992-l6l24pco	58	4	through	through	IN
cord-350992-l6l24pco	58	5	their	-PRON-	PRP$
cord-350992-l6l24pco	58	6	antigen	antigen	NN
cord-350992-l6l24pco	58	7	specific	specific	JJ
cord-350992-l6l24pco	58	8	receptors	receptor	NNS
cord-350992-l6l24pco	58	9	,	,	,
cord-350992-l6l24pco	58	10	interact	interact	VBP
cord-350992-l6l24pco	58	11	with	with	IN
cord-350992-l6l24pco	58	12	APCs	apc	NNS
cord-350992-l6l24pco	58	13	,	,	,
cord-350992-l6l24pco	58	14	recognizing	recognize	VBG
cord-350992-l6l24pco	58	15	antigenic	antigenic	JJ
cord-350992-l6l24pco	58	16	peptides	peptide	NNS
cord-350992-l6l24pco	58	17	immobilized	immobilize	VBN
cord-350992-l6l24pco	58	18	on	on	IN
cord-350992-l6l24pco	58	19	their	-PRON-	PRP$
cord-350992-l6l24pco	58	20	surface	surface	NN
cord-350992-l6l24pco	58	21	by	by	IN
cord-350992-l6l24pco	58	22	Major	Major	NNP
cord-350992-l6l24pco	58	23	Histocompatibility	Histocompatibility	NNP
cord-350992-l6l24pco	58	24	Complex	Complex	NNP
cord-350992-l6l24pco	58	25	(	(	-LRB-
cord-350992-l6l24pco	58	26	MHC	MHC	NNP
cord-350992-l6l24pco	58	27	)	)	-RRB-
cord-350992-l6l24pco	58	28	class	class	NN
cord-350992-l6l24pco	58	29	I	-PRON-	PRP
cord-350992-l6l24pco	58	30	(	(	-LRB-
cord-350992-l6l24pco	58	31	for	for	IN
cord-350992-l6l24pco	58	32	CD8	CD8	NNP
cord-350992-l6l24pco	58	33	+	+	CC
cord-350992-l6l24pco	58	34	T	T	NNP
cord-350992-l6l24pco	58	35	cytotoxic	cytotoxic	JJ
cord-350992-l6l24pco	58	36	cells	cell	NNS
cord-350992-l6l24pco	58	37	)	)	-RRB-
cord-350992-l6l24pco	58	38	and	and	CC
cord-350992-l6l24pco	58	39	MHC	MHC	NNP
cord-350992-l6l24pco	58	40	class	class	NN
cord-350992-l6l24pco	58	41	II	II	NNP
cord-350992-l6l24pco	58	42	(	(	-LRB-
cord-350992-l6l24pco	58	43	for	for	IN
cord-350992-l6l24pco	58	44	CD4	CD4	NNP
cord-350992-l6l24pco	58	45	+	+	CC
cord-350992-l6l24pco	58	46	T	T	NNP
cord-350992-l6l24pco	58	47	helper	helper	NN
cord-350992-l6l24pco	58	48	cells	cell	NNS
cord-350992-l6l24pco	58	49	)	)	-RRB-
cord-350992-l6l24pco	58	50	molecules	molecule	NNS
cord-350992-l6l24pco	58	51	.	.	.
cord-350992-l6l24pco	59	1	MHC	MHC	NNP
cord-350992-l6l24pco	59	2	class	class	NN
cord-350992-l6l24pco	60	1	I	-PRON-	PRP
cord-350992-l6l24pco	60	2	molecules	molecule	NNS
cord-350992-l6l24pco	60	3	are	be	VBP
cord-350992-l6l24pco	60	4	loaded	load	VBN
cord-350992-l6l24pco	60	5	with	with	IN
cord-350992-l6l24pco	60	6	those	those	DT
cord-350992-l6l24pco	60	7	antigens	antigen	NNS
cord-350992-l6l24pco	60	8	mainly	mainly	RB
cord-350992-l6l24pco	60	9	derived	derive	VBN
cord-350992-l6l24pco	60	10	from	from	IN
cord-350992-l6l24pco	60	11	proteasome	proteasome	VBN
cord-350992-l6l24pco	60	12	degradation	degradation	NN
cord-350992-l6l24pco	60	13	of	of	IN
cord-350992-l6l24pco	60	14	cytosolic	cytosolic	JJ
cord-350992-l6l24pco	60	15	proteins	protein	NNS
cord-350992-l6l24pco	60	16	(	(	-LRB-
cord-350992-l6l24pco	60	17	like	like	IN
cord-350992-l6l24pco	60	18	viral	viral	JJ
cord-350992-l6l24pco	60	19	proteins	protein	NNS
cord-350992-l6l24pco	60	20	)	)	-RRB-
cord-350992-l6l24pco	60	21	in	in	IN
cord-350992-l6l24pco	60	22	the	the	DT
cord-350992-l6l24pco	60	23	ER	er	NN
cord-350992-l6l24pco	60	24	,	,	,
cord-350992-l6l24pco	60	25	but	but	CC
cord-350992-l6l24pco	60	26	also	also	RB
cord-350992-l6l24pco	60	27	from	from	IN
cord-350992-l6l24pco	60	28	phagocytosed	phagocytosed	NNP
cord-350992-l6l24pco	60	29	/	/	SYM
cord-350992-l6l24pco	60	30	endocytosed	endocytosed	JJ
cord-350992-l6l24pco	60	31	material	material	NN
cord-350992-l6l24pco	60	32	,	,	,
cord-350992-l6l24pco	60	33	processed	process	VBN
cord-350992-l6l24pco	60	34	through	through	IN
cord-350992-l6l24pco	60	35	endosomes	endosome	NNS
cord-350992-l6l24pco	60	36	and	and	CC
cord-350992-l6l24pco	60	37	lysosomes	lysosome	NNS
cord-350992-l6l24pco	60	38	.	.	.
cord-350992-l6l24pco	61	1	MHC	MHC	NNP
cord-350992-l6l24pco	61	2	class	class	NN
cord-350992-l6l24pco	61	3	II	II	NNP
cord-350992-l6l24pco	61	4	molecules	molecule	NNS
cord-350992-l6l24pco	61	5	bind	bind	VBP
cord-350992-l6l24pco	61	6	antigens	antigen	NNS
cord-350992-l6l24pco	61	7	obtained	obtain	VBN
cord-350992-l6l24pco	61	8	by	by	IN
cord-350992-l6l24pco	61	9	endosomal	endosomal	NNP
cord-350992-l6l24pco	61	10	and	and	CC
cord-350992-l6l24pco	61	11	lysosomal	lysosomal	JJ
cord-350992-l6l24pco	61	12	processing	processing	NN
cord-350992-l6l24pco	61	13	and	and	CC
cord-350992-l6l24pco	61	14	,	,	,
cord-350992-l6l24pco	61	15	as	as	IN
cord-350992-l6l24pco	61	16	MHC	MHC	NNP
cord-350992-l6l24pco	61	17	class	class	NN
cord-350992-l6l24pco	61	18	I	-PRON-	PRP
cord-350992-l6l24pco	61	19	,	,	,
cord-350992-l6l24pco	61	20	require	require	VBP
cord-350992-l6l24pco	61	21	the	the	DT
cord-350992-l6l24pco	61	22	low	low	JJ
cord-350992-l6l24pco	61	23	pH	ph	NN
cord-350992-l6l24pco	61	24	of	of	IN
cord-350992-l6l24pco	61	25	these	these	DT
cord-350992-l6l24pco	61	26	organelles	organelle	NNS
cord-350992-l6l24pco	61	27	to	to	TO
cord-350992-l6l24pco	61	28	activate	activate	VB
cord-350992-l6l24pco	61	29	protease	protease	NN
cord-350992-l6l24pco	61	30	and	and	CC
cord-350992-l6l24pco	61	31	other	other	JJ
cord-350992-l6l24pco	61	32	enzymes	enzyme	NNS
cord-350992-l6l24pco	61	33	and	and	CC
cord-350992-l6l24pco	61	34	form	form	VBP
cord-350992-l6l24pco	61	35	the	the	DT
cord-350992-l6l24pco	61	36	complexed	complexed	JJ
cord-350992-l6l24pco	61	37	antigen	antigen	NN
cord-350992-l6l24pco	61	38	[	[	-LRB-
cord-350992-l6l24pco	61	39	27	27	CD
cord-350992-l6l24pco	61	40	,	,	,
cord-350992-l6l24pco	61	41	28	28	CD
cord-350992-l6l24pco	61	42	]	]	-RRB-
cord-350992-l6l24pco	61	43	.	.	.
cord-350992-l6l24pco	62	1	CQ	CQ	NNP
cord-350992-l6l24pco	62	2	downregulates	downregulate	VBZ
cord-350992-l6l24pco	62	3	PICALM	PICALM	NNP
cord-350992-l6l24pco	62	4	affecting	affect	VBG
cord-350992-l6l24pco	62	5	CME	CME	NNP
cord-350992-l6l24pco	62	6	and	and	CC
cord-350992-l6l24pco	62	7	possibly	possibly	RB
cord-350992-l6l24pco	62	8	antigen	antigen	NN
cord-350992-l6l24pco	62	9	-	-	HYPH
cord-350992-l6l24pco	62	10	processing	processing	NN
cord-350992-l6l24pco	62	11	[	[	-LRB-
cord-350992-l6l24pco	62	12	15	15	CD
cord-350992-l6l24pco	62	13	]	]	-RRB-
cord-350992-l6l24pco	62	14	.	.	.
cord-350992-l6l24pco	63	1	CQ	CQ	NNP
cord-350992-l6l24pco	63	2	/	/	SYM
cord-350992-l6l24pco	63	3	HCQ	HCQ	NNP
cord-350992-l6l24pco	63	4	also	also	RB
cord-350992-l6l24pco	63	5	alkalinize	alkalinize	VBP
cord-350992-l6l24pco	63	6	vesicles	vesicle	NNS
cord-350992-l6l24pco	63	7	of	of	IN
cord-350992-l6l24pco	63	8	the	the	DT
cord-350992-l6l24pco	63	9	endosome	endosome	NN
cord-350992-l6l24pco	63	10	-	-	HYPH
cord-350992-l6l24pco	63	11	lysosome	lysosome	NN
cord-350992-l6l24pco	63	12	-	-	HYPH
cord-350992-l6l24pco	63	13	autophagy	autophagy	NN
cord-350992-l6l24pco	63	14	pathway	pathway	NN
cord-350992-l6l24pco	63	15	,	,	,
cord-350992-l6l24pco	63	16	possibly	possibly	RB
cord-350992-l6l24pco	63	17	further	further	RB
cord-350992-l6l24pco	63	18	interfering	interfere	VBG
cord-350992-l6l24pco	63	19	with	with	IN
cord-350992-l6l24pco	63	20	antigen	antigen	NN
cord-350992-l6l24pco	63	21	presentation	presentation	NN
cord-350992-l6l24pco	63	22	by	by	IN
cord-350992-l6l24pco	63	23	APCs	apc	NNS
cord-350992-l6l24pco	63	24	,	,	,
cord-350992-l6l24pco	63	25	both	both	DT
cord-350992-l6l24pco	63	26	acting	act	VBG
cord-350992-l6l24pco	63	27	on	on	IN
cord-350992-l6l24pco	63	28	antigen	antigen	NN
cord-350992-l6l24pco	63	29	degradation	degradation	NN
cord-350992-l6l24pco	63	30	and	and	CC
cord-350992-l6l24pco	63	31	MHC	MHC	NNP
cord-350992-l6l24pco	63	32	molecules	molecule	NNS
cord-350992-l6l24pco	63	33	processing	process	VBG
cord-350992-l6l24pco	63	34	.	.	.
cord-350992-l6l24pco	64	1	The	the	DT
cord-350992-l6l24pco	64	2	inhibition	inhibition	NN
cord-350992-l6l24pco	64	3	of	of	IN
cord-350992-l6l24pco	64	4	antigen	antigen	NN
cord-350992-l6l24pco	64	5	presentation	presentation	NN
cord-350992-l6l24pco	64	6	may	may	MD
cord-350992-l6l24pco	64	7	reduce	reduce	VB
cord-350992-l6l24pco	64	8	T	T	NNP
cord-350992-l6l24pco	64	9	cell	cell	NN
cord-350992-l6l24pco	64	10	activation	activation	NN
cord-350992-l6l24pco	64	11	and	and	CC
cord-350992-l6l24pco	64	12	differentiation	differentiation	NN
cord-350992-l6l24pco	64	13	and	and	CC
cord-350992-l6l24pco	64	14	in	in	IN
cord-350992-l6l24pco	64	15	turn	turn	NN
cord-350992-l6l24pco	64	16	decrease	decrease	VB
cord-350992-l6l24pco	64	17	the	the	DT
cord-350992-l6l24pco	64	18	production	production	NN
cord-350992-l6l24pco	64	19	of	of	IN
cord-350992-l6l24pco	64	20	pro	pro	JJ
cord-350992-l6l24pco	64	21	-	-	JJ
cord-350992-l6l24pco	64	22	inflammatory	inflammatory	JJ
cord-350992-l6l24pco	64	23	cytokines	cytokine	NNS
cord-350992-l6l24pco	64	24	.	.	.
cord-350992-l6l24pco	65	1	TLRs	tlr	NNS
cord-350992-l6l24pco	65	2	are	be	VBP
cord-350992-l6l24pco	65	3	involved	involve	VBN
cord-350992-l6l24pco	65	4	in	in	IN
cord-350992-l6l24pco	65	5	innate	innate	JJ
cord-350992-l6l24pco	65	6	immunity	immunity	NN
cord-350992-l6l24pco	65	7	against	against	IN
cord-350992-l6l24pco	65	8	bacteria	bacteria	NNS
cord-350992-l6l24pco	65	9	and	and	CC
cord-350992-l6l24pco	65	10	viruses	virus	NNS
cord-350992-l6l24pco	65	11	.	.	.
cord-350992-l6l24pco	66	1	TLR7	TLR7	NNP
cord-350992-l6l24pco	66	2	and	and	CC
cord-350992-l6l24pco	66	3	TLR9	TLR9	NNP
cord-350992-l6l24pco	66	4	are	be	VBP
cord-350992-l6l24pco	66	5	located	locate	VBN
cord-350992-l6l24pco	66	6	in	in	IN
cord-350992-l6l24pco	66	7	the	the	DT
cord-350992-l6l24pco	66	8	ER	er	NN
cord-350992-l6l24pco	66	9	and	and	CC
cord-350992-l6l24pco	66	10	move	move	VB
cord-350992-l6l24pco	66	11	to	to	IN
cord-350992-l6l24pco	66	12	endosomes	endosome	NNS
cord-350992-l6l24pco	66	13	and	and	CC
cord-350992-l6l24pco	66	14	lysosomes	lysosome	NNS
cord-350992-l6l24pco	66	15	where	where	WRB
cord-350992-l6l24pco	66	16	they	-PRON-	PRP
cord-350992-l6l24pco	66	17	recognize	recognize	VBP
cord-350992-l6l24pco	66	18	bacterial	bacterial	JJ
cord-350992-l6l24pco	66	19	and	and	CC
cord-350992-l6l24pco	66	20	viral	viral	JJ
cord-350992-l6l24pco	66	21	nucleic	nucleic	JJ
cord-350992-l6l24pco	66	22	acids	acid	NNS
cord-350992-l6l24pco	66	23	.	.	.
cord-350992-l6l24pco	67	1	By	by	IN
cord-350992-l6l24pco	67	2	this	this	DT
cord-350992-l6l24pco	67	3	binding	binding	NN
cord-350992-l6l24pco	67	4	,	,	,
cord-350992-l6l24pco	67	5	their	-PRON-	PRP$
cord-350992-l6l24pco	67	6	activation	activation	NN
cord-350992-l6l24pco	67	7	results	result	NNS
cord-350992-l6l24pco	67	8	in	in	IN
cord-350992-l6l24pco	67	9	the	the	DT
cord-350992-l6l24pco	67	10	production	production	NN
cord-350992-l6l24pco	67	11	of	of	IN
cord-350992-l6l24pco	67	12	pro	pro	JJ
cord-350992-l6l24pco	67	13	-	-	JJ
cord-350992-l6l24pco	67	14	inflammatory	inflammatory	JJ
cord-350992-l6l24pco	67	15	cytokines	cytokine	NNS
cord-350992-l6l24pco	67	16	and	and	CC
cord-350992-l6l24pco	67	17	chemokine	chemokine	NN
cord-350992-l6l24pco	67	18	like	like	IN
cord-350992-l6l24pco	67	19	interleukin-6	interleukin-6	NNP
cord-350992-l6l24pco	67	20	(	(	-LRB-
cord-350992-l6l24pco	67	21	IL-6	IL-6	NNP
cord-350992-l6l24pco	67	22	)	)	-RRB-
cord-350992-l6l24pco	67	23	,	,	,
cord-350992-l6l24pco	67	24	interleukin-12	interleukin-12	XX
cord-350992-l6l24pco	67	25	(	(	-LRB-
cord-350992-l6l24pco	67	26	IL-12	IL-12	NNP
cord-350992-l6l24pco	67	27	)	)	-RRB-
cord-350992-l6l24pco	67	28	,	,	,
cord-350992-l6l24pco	67	29	type	type	NN
cord-350992-l6l24pco	67	30	I	-PRON-	PRP
cord-350992-l6l24pco	67	31	interferons	interferon	NNS
cord-350992-l6l24pco	67	32	(	(	-LRB-
cord-350992-l6l24pco	67	33	IFN1s	IFN1s	NNP
cord-350992-l6l24pco	67	34	)	)	-RRB-
cord-350992-l6l24pco	67	35	,	,	,
cord-350992-l6l24pco	67	36	interferon-	interferon-	''
cord-350992-l6l24pco	67	37	(	(	-LRB-
cord-350992-l6l24pco	67	38	IFN-	IFN-	NNP
cord-350992-l6l24pco	67	39	)	)	-RRB-
cord-350992-l6l24pco	67	40	and	and	CC
cord-350992-l6l24pco	67	41	cytokines	cytokine	NNS
cord-350992-l6l24pco	67	42	promoting	promote	VBG
cord-350992-l6l24pco	67	43	the	the	DT
cord-350992-l6l24pco	67	44	stimulation	stimulation	NN
cord-350992-l6l24pco	67	45	of	of	IN
cord-350992-l6l24pco	67	46	Th1	th1	NN
cord-350992-l6l24pco	67	47	cells	cell	NNS
cord-350992-l6l24pco	67	48	and	and	CC
cord-350992-l6l24pco	67	49	disrupting	disrupt	VBG
cord-350992-l6l24pco	67	50	the	the	DT
cord-350992-l6l24pco	67	51	Th1	th1	CD
cord-350992-l6l24pco	67	52	/	/	SYM
cord-350992-l6l24pco	67	53	Th2	th2	CD
cord-350992-l6l24pco	67	54	balance	balance	NN
cord-350992-l6l24pco	67	55	.	.	.
cord-350992-l6l24pco	68	1	The	the	DT
cord-350992-l6l24pco	68	2	activation	activation	NN
cord-350992-l6l24pco	68	3	of	of	IN
cord-350992-l6l24pco	68	4	TLR7	TLR7	NNP
cord-350992-l6l24pco	68	5	and	and	CC
cord-350992-l6l24pco	68	6	TLR9	TLR9	NNP
cord-350992-l6l24pco	68	7	by	by	IN
cord-350992-l6l24pco	68	8	their	-PRON-	PRP$
cord-350992-l6l24pco	68	9	ligands	ligand	NNS
cord-350992-l6l24pco	68	10	requires	require	VBZ
cord-350992-l6l24pco	68	11	the	the	DT
cord-350992-l6l24pco	68	12	low	low	JJ
cord-350992-l6l24pco	68	13	pH	ph	NN
cord-350992-l6l24pco	68	14	of	of	IN
cord-350992-l6l24pco	68	15	endosomes	endosome	NNS
cord-350992-l6l24pco	68	16	and	and	CC
cord-350992-l6l24pco	68	17	lysosomes	lysosome	NNS
cord-350992-l6l24pco	68	18	and	and	CC
cord-350992-l6l24pco	68	19	an	an	DT
cord-350992-l6l24pco	68	20	active	active	JJ
cord-350992-l6l24pco	68	21	autophagic	autophagic	NN
cord-350992-l6l24pco	68	22	pathway	pathway	NN
cord-350992-l6l24pco	68	23	,	,	,
cord-350992-l6l24pco	68	24	then	then	RB
cord-350992-l6l24pco	68	25	CQ	CQ	NNP
cord-350992-l6l24pco	68	26	/	/	SYM
cord-350992-l6l24pco	68	27	HCQ	HCQ	NNP
cord-350992-l6l24pco	68	28	,	,	,
cord-350992-l6l24pco	68	29	through	through	IN
cord-350992-l6l24pco	68	30	vesicle	vesicle	NN
cord-350992-l6l24pco	68	31	alkalinization	alkalinization	NN
cord-350992-l6l24pco	68	32	,	,	,
cord-350992-l6l24pco	68	33	may	may	MD
cord-350992-l6l24pco	68	34	inhibit	inhibit	VB
cord-350992-l6l24pco	68	35	this	this	DT
cord-350992-l6l24pco	68	36	interaction	interaction	NN
cord-350992-l6l24pco	68	37	and	and	CC
cord-350992-l6l24pco	68	38	TLR	TLR	NNP
cord-350992-l6l24pco	68	39	signaling	signal	VBG
cord-350992-l6l24pco	68	40	,	,	,
cord-350992-l6l24pco	68	41	in	in	IN
cord-350992-l6l24pco	68	42	turn	turn	NN
cord-350992-l6l24pco	68	43	inhibiting	inhibit	VBG
cord-350992-l6l24pco	68	44	the	the	DT
cord-350992-l6l24pco	68	45	inflammatory	inflammatory	JJ
cord-350992-l6l24pco	68	46	response	response	NN
cord-350992-l6l24pco	68	47	[	[	-LRB-
cord-350992-l6l24pco	68	48	31	31	CD
cord-350992-l6l24pco	68	49	]	]	-RRB-
cord-350992-l6l24pco	68	50	.	.	.
cord-350992-l6l24pco	69	1	Matrix	matrix	NN
cord-350992-l6l24pco	69	2	metalloproteinases	metalloproteinase	NNS
cord-350992-l6l24pco	69	3	(	(	-LRB-
cord-350992-l6l24pco	69	4	MMPs	MMPs	NNP
cord-350992-l6l24pco	69	5	)	)	-RRB-
cord-350992-l6l24pco	69	6	are	be	VBP
cord-350992-l6l24pco	69	7	a	a	DT
cord-350992-l6l24pco	69	8	family	family	NN
cord-350992-l6l24pco	69	9	of	of	IN
cord-350992-l6l24pco	69	10	zinc	zinc	NN
cord-350992-l6l24pco	69	11	endopeptidases	endopeptidase	NNS
cord-350992-l6l24pco	69	12	that	that	WDT
cord-350992-l6l24pco	69	13	regulate	regulate	VBP
cord-350992-l6l24pco	69	14	inflammation	inflammation	NN
cord-350992-l6l24pco	69	15	and	and	CC
cord-350992-l6l24pco	69	16	tissue	tissue	NN
cord-350992-l6l24pco	69	17	repair	repair	NN
cord-350992-l6l24pco	69	18	at	at	IN
cord-350992-l6l24pco	69	19	several	several	JJ
cord-350992-l6l24pco	69	20	levels	level	NNS
cord-350992-l6l24pco	69	21	.	.	.
cord-350992-l6l24pco	70	1	MMPs	MMPs	NNP
cord-350992-l6l24pco	70	2	regulate	regulate	VBP
cord-350992-l6l24pco	70	3	pro	pro	JJ
cord-350992-l6l24pco	70	4	-	-	JJ
cord-350992-l6l24pco	70	5	inflammatory	inflammatory	JJ
cord-350992-l6l24pco	70	6	and	and	CC
cord-350992-l6l24pco	70	7	antiinflammatory	antiinflammatory	JJ
cord-350992-l6l24pco	70	8	cytokine	cytokine	NN
cord-350992-l6l24pco	70	9	and	and	CC
cord-350992-l6l24pco	70	10	chemokine	chemokine	NN
cord-350992-l6l24pco	70	11	production	production	NN
cord-350992-l6l24pco	70	12	by	by	IN
cord-350992-l6l24pco	70	13	proteolytic	proteolytic	JJ
cord-350992-l6l24pco	70	14	processing	processing	NN
cord-350992-l6l24pco	70	15	and	and	CC
cord-350992-l6l24pco	70	16	may	may	MD
cord-350992-l6l24pco	70	17	in	in	IN
cord-350992-l6l24pco	70	18	turn	turn	NN
cord-350992-l6l24pco	70	19	be	be	VB
cord-350992-l6l24pco	70	20	induced	induce	VBN
cord-350992-l6l24pco	70	21	by	by	IN
cord-350992-l6l24pco	70	22	cytokines	cytokine	NNS
cord-350992-l6l24pco	70	23	and	and	CC
cord-350992-l6l24pco	70	24	chemokines	chemokine	NNS
cord-350992-l6l24pco	70	25	.	.	.
cord-350992-l6l24pco	71	1	CQ	CQ	NNP
cord-350992-l6l24pco	71	2	has	have	VBZ
cord-350992-l6l24pco	71	3	been	be	VBN
cord-350992-l6l24pco	71	4	shown	show	VBN
cord-350992-l6l24pco	71	5	to	to	TO
cord-350992-l6l24pco	71	6	downregulate	downregulate	VB
cord-350992-l6l24pco	71	7	MMP-9	MMP-9	NNP
cord-350992-l6l24pco	71	8	expression	expression	NN
cord-350992-l6l24pco	71	9	through	through	IN
cord-350992-l6l24pco	71	10	the	the	DT
cord-350992-l6l24pco	71	11	inhibition	inhibition	NN
cord-350992-l6l24pco	71	12	of	of	IN
cord-350992-l6l24pco	71	13	TLR9	TLR9	NNP
cord-350992-l6l24pco	71	14	signaling	signal	VBG
cord-350992-l6l24pco	71	15	[	[	-LRB-
cord-350992-l6l24pco	71	16	32	32	CD
cord-350992-l6l24pco	71	17	]	]	-RRB-
cord-350992-l6l24pco	71	18	.	.	.
cord-350992-l6l24pco	72	1	CQ	CQ	NNP
cord-350992-l6l24pco	72	2	has	have	VBZ
cord-350992-l6l24pco	72	3	also	also	RB
cord-350992-l6l24pco	72	4	been	be	VBN
cord-350992-l6l24pco	72	5	demonstrated	demonstrate	VBN
cord-350992-l6l24pco	72	6	to	to	TO
cord-350992-l6l24pco	72	7	inhibit	inhibit	VB
cord-350992-l6l24pco	72	8	phospholipase	phospholipase	NN
cord-350992-l6l24pco	72	9	A2	a2	NN
cord-350992-l6l24pco	72	10	and	and	CC
cord-350992-l6l24pco	72	11	block	block	VB
cord-350992-l6l24pco	72	12	the	the	DT
cord-350992-l6l24pco	72	13	arachidonic	arachidonic	JJ
cord-350992-l6l24pco	72	14	acid	acid	NN
cord-350992-l6l24pco	72	15	cascade	cascade	NN
cord-350992-l6l24pco	72	16	that	that	WDT
cord-350992-l6l24pco	72	17	leads	lead	VBZ
cord-350992-l6l24pco	72	18	to	to	IN
cord-350992-l6l24pco	72	19	the	the	DT
cord-350992-l6l24pco	72	20	production	production	NN
cord-350992-l6l24pco	72	21	of	of	IN
cord-350992-l6l24pco	72	22	prostaglandins	prostaglandin	NNS
cord-350992-l6l24pco	72	23	and	and	CC
cord-350992-l6l24pco	72	24	tromboxanes	tromboxane	NNS
cord-350992-l6l24pco	72	25	.	.	.
cord-350992-l6l24pco	73	1	In	in	IN
cord-350992-l6l24pco	73	2	this	this	DT
cord-350992-l6l24pco	73	3	context	context	NN
cord-350992-l6l24pco	73	4	,	,	,
cord-350992-l6l24pco	73	5	CQ	CQ	NNP
cord-350992-l6l24pco	73	6	may	may	MD
cord-350992-l6l24pco	73	7	have	have	VB
cord-350992-l6l24pco	73	8	both	both	DT
cord-350992-l6l24pco	73	9	antiinflammatory	antiinflammatory	JJ
cord-350992-l6l24pco	73	10	and	and	CC
cord-350992-l6l24pco	73	11	anti	anti	JJ
cord-350992-l6l24pco	73	12	-	-	JJ
cord-350992-l6l24pco	73	13	thrombotic	thrombotic	JJ
cord-350992-l6l24pco	73	14	effects	effect	NNS
cord-350992-l6l24pco	73	15	[	[	-LRB-
cord-350992-l6l24pco	73	16	33	33	CD
cord-350992-l6l24pco	73	17	]	]	-RRB-
cord-350992-l6l24pco	73	18	.	.	.
cord-350992-l6l24pco	74	1	This	this	DT
cord-350992-l6l24pco	74	2	is	be	VBZ
cord-350992-l6l24pco	74	3	an	an	DT
cord-350992-l6l24pco	74	4	important	important	JJ
cord-350992-l6l24pco	74	5	point	point	NN
cord-350992-l6l24pco	74	6	,	,	,
cord-350992-l6l24pco	74	7	since	since	IN
cord-350992-l6l24pco	74	8	Sars	Sars	NNP
cord-350992-l6l24pco	74	9	-	-	HYPH
cord-350992-l6l24pco	74	10	Cov-2	Cov-2	NNP
cord-350992-l6l24pco	74	11	can	can	MD
cord-350992-l6l24pco	74	12	induce	induce	VB
cord-350992-l6l24pco	74	13	pulmonary	pulmonary	JJ
cord-350992-l6l24pco	74	14	microthrombi	microthrombi	NN
cord-350992-l6l24pco	74	15	and	and	CC
cord-350992-l6l24pco	74	16	coagulopathy	coagulopathy	NN
cord-350992-l6l24pco	74	17	,	,	,
cord-350992-l6l24pco	74	18	being	be	VBG
cord-350992-l6l24pco	74	19	characterized	characterize	VBN
cord-350992-l6l24pco	74	20	in	in	IN
cord-350992-l6l24pco	74	21	its	-PRON-	PRP$
cord-350992-l6l24pco	74	22	severe	severe	JJ
cord-350992-l6l24pco	74	23	forms	form	NNS
cord-350992-l6l24pco	74	24	by	by	IN
cord-350992-l6l24pco	74	25	D	d	NN
cord-350992-l6l24pco	74	26	-	-	HYPH
cord-350992-l6l24pco	74	27	dimer	dimer	NN
cord-350992-l6l24pco	74	28	level	level	NN
cord-350992-l6l24pco	74	29	elevation	elevation	NN
cord-350992-l6l24pco	74	30	[	[	-LRB-
cord-350992-l6l24pco	74	31	34	34	CD
cord-350992-l6l24pco	74	32	,	,	,
cord-350992-l6l24pco	74	33	35	35	CD
cord-350992-l6l24pco	74	34	]	]	-RRB-
cord-350992-l6l24pco	74	35	.	.	.
cord-350992-l6l24pco	75	1	Interestingly	interestingly	RB
cord-350992-l6l24pco	75	2	,	,	,
cord-350992-l6l24pco	75	3	phospholipase	phospholipase	NNP
cord-350992-l6l24pco	75	4	A2	A2	NNP
cord-350992-l6l24pco	75	5	has	have	VBZ
cord-350992-l6l24pco	75	6	recently	recently	RB
cord-350992-l6l24pco	75	7	been	be	VBN
cord-350992-l6l24pco	75	8	shown	show	VBN
cord-350992-l6l24pco	75	9	to	to	TO
cord-350992-l6l24pco	75	10	be	be	VB
cord-350992-l6l24pco	75	11	critically	critically	RB
cord-350992-l6l24pco	75	12	involved	involve	VBN
cord-350992-l6l24pco	75	13	in	in	IN
cord-350992-l6l24pco	75	14	coronavirus	coronavirus	NN
cord-350992-l6l24pco	75	15	replication	replication	NN
cord-350992-l6l24pco	75	16	due	due	IN
cord-350992-l6l24pco	75	17	to	to	IN
cord-350992-l6l24pco	75	18	its	-PRON-	PRP$
cord-350992-l6l24pco	75	19	role	role	NN
cord-350992-l6l24pco	75	20	in	in	IN
cord-350992-l6l24pco	75	21	the	the	DT
cord-350992-l6l24pco	75	22	production	production	NN
cord-350992-l6l24pco	75	23	of	of	IN
cord-350992-l6l24pco	75	24	lipids	lipid	NNS
cord-350992-l6l24pco	75	25	required	require	VBN
cord-350992-l6l24pco	75	26	to	to	TO
cord-350992-l6l24pco	75	27	form	form	VB
cord-350992-l6l24pco	75	28	the	the	DT
cord-350992-l6l24pco	75	29	membranous	membranous	JJ
cord-350992-l6l24pco	75	30	structures	structure	NNS
cord-350992-l6l24pco	75	31	that	that	WDT
cord-350992-l6l24pco	75	32	are	be	VBP
cord-350992-l6l24pco	75	33	essential	essential	JJ
cord-350992-l6l24pco	75	34	for	for	IN
cord-350992-l6l24pco	75	35	virus	virus	NN
cord-350992-l6l24pco	75	36	replication	replication	NN
cord-350992-l6l24pco	75	37	and	and	CC
cord-350992-l6l24pco	75	38	transcription	transcription	NN
cord-350992-l6l24pco	75	39	[	[	-LRB-
cord-350992-l6l24pco	75	40	36	36	CD
cord-350992-l6l24pco	75	41	]	]	-RRB-
cord-350992-l6l24pco	75	42	.	.	.
cord-350992-l6l24pco	76	1	Then	then	RB
cord-350992-l6l24pco	76	2	,	,	,
cord-350992-l6l24pco	76	3	inhibiting	inhibit	VBG
cord-350992-l6l24pco	76	4	phospholipase	phospholipase	NN
cord-350992-l6l24pco	76	5	A2	A2	NNP
cord-350992-l6l24pco	76	6	,	,	,
cord-350992-l6l24pco	76	7	CQ	CQ	NNP
cord-350992-l6l24pco	76	8	may	may	MD
cord-350992-l6l24pco	76	9	be	be	VB
cord-350992-l6l24pco	76	10	a	a	DT
cord-350992-l6l24pco	76	11	triple	triple	JJ
cord-350992-l6l24pco	76	12	arm	arm	NN
cord-350992-l6l24pco	76	13	against	against	IN
cord-350992-l6l24pco	76	14	Sars	Sars	NNP
cord-350992-l6l24pco	76	15	-	-	HYPH
cord-350992-l6l24pco	76	16	Cov-2	Cov-2	NNP
cord-350992-l6l24pco	76	17	,	,	,
cord-350992-l6l24pco	76	18	acting	act	VBG
cord-350992-l6l24pco	76	19	through	through	IN
cord-350992-l6l24pco	76	20	the	the	DT
cord-350992-l6l24pco	76	21	anti	anti	JJ
cord-350992-l6l24pco	76	22	-	-	JJ
cord-350992-l6l24pco	76	23	inflammatory	inflammatory	JJ
cord-350992-l6l24pco	76	24	,	,	,
cord-350992-l6l24pco	76	25	anti	anti	JJ
cord-350992-l6l24pco	76	26	-	-	JJ
cord-350992-l6l24pco	76	27	thrombotic	thrombotic	JJ
cord-350992-l6l24pco	76	28	and	and	CC
cord-350992-l6l24pco	76	29	antiviral	antiviral	JJ
cord-350992-l6l24pco	76	30	mechanisms	mechanism	NNS
cord-350992-l6l24pco	76	31	.	.	.
cord-350992-l6l24pco	77	1	As	as	IN
cord-350992-l6l24pco	77	2	stated	state	VBN
cord-350992-l6l24pco	77	3	above	above	RB
cord-350992-l6l24pco	77	4	,	,	,
cord-350992-l6l24pco	77	5	respiratory	respiratory	JJ
cord-350992-l6l24pco	77	6	viruses	virus	NNS
cord-350992-l6l24pco	77	7	can	can	MD
cord-350992-l6l24pco	77	8	activate	activate	VB
cord-350992-l6l24pco	77	9	the	the	DT
cord-350992-l6l24pco	77	10	p38	p38	CD
cord-350992-l6l24pco	77	11	MAPK	MAPK	NNP
cord-350992-l6l24pco	77	12	pathway	pathway	NN
cord-350992-l6l24pco	77	13	in	in	IN
cord-350992-l6l24pco	77	14	infected	infected	JJ
cord-350992-l6l24pco	77	15	airway	airway	NN
cord-350992-l6l24pco	77	16	epithelium	epithelium	NN
cord-350992-l6l24pco	77	17	and	and	CC
cord-350992-l6l24pco	77	18	harness	harness	VB
cord-350992-l6l24pco	77	19	the	the	DT
cord-350992-l6l24pco	77	20	trafficking	traffic	VBG
cord-350992-l6l24pco	77	21	machinery	machinery	NN
cord-350992-l6l24pco	77	22	of	of	IN
cord-350992-l6l24pco	77	23	infected	infected	JJ
cord-350992-l6l24pco	77	24	cells	cell	NNS
cord-350992-l6l24pco	77	25	to	to	TO
cord-350992-l6l24pco	77	26	assist	assist	VB
cord-350992-l6l24pco	77	27	viral	viral	JJ
cord-350992-l6l24pco	77	28	assembly	assembly	NN
cord-350992-l6l24pco	77	29	and	and	CC
cord-350992-l6l24pco	77	30	spread	spread	NN
cord-350992-l6l24pco	77	31	.	.	.
cord-350992-l6l24pco	78	1	p38	p38	CD
cord-350992-l6l24pco	78	2	MAPK	MAPK	NNP
cord-350992-l6l24pco	78	3	activation	activation	NN
cord-350992-l6l24pco	78	4	also	also	RB
cord-350992-l6l24pco	78	5	leads	lead	VBZ
cord-350992-l6l24pco	78	6	to	to	IN
cord-350992-l6l24pco	78	7	the	the	DT
cord-350992-l6l24pco	78	8	release	release	NN
cord-350992-l6l24pco	78	9	of	of	IN
cord-350992-l6l24pco	78	10	cytokines	cytokine	NNS
cord-350992-l6l24pco	78	11	like	like	IN
cord-350992-l6l24pco	78	12	tumor	tumor	NN
cord-350992-l6l24pco	78	13	necrosis	necrosis	NN
cord-350992-l6l24pco	78	14	factor-	factor-	NNP
cord-350992-l6l24pco	78	15	(	(	-LRB-
cord-350992-l6l24pco	78	16	TNF	TNF	NNP
cord-350992-l6l24pco	78	17	-	-	HYPH
cord-350992-l6l24pco	78	18	α	α	NNP
cord-350992-l6l24pco	78	19	)	)	-RRB-
cord-350992-l6l24pco	78	20	,	,	,
cord-350992-l6l24pco	78	21	interleukin-1	interleukin-1	NNP
cord-350992-l6l24pco	78	22	(	(	-LRB-
cord-350992-l6l24pco	78	23	IL-1β	IL-1β	NNP
cord-350992-l6l24pco	78	24	)	)	-RRB-
cord-350992-l6l24pco	78	25	,	,	.
cord-350992-l6l24pco	79	1	IL-17	IL-17	NNP
cord-350992-l6l24pco	80	1	and	and	CC
cord-350992-l6l24pco	80	2	IL-6	IL-6	NNP
cord-350992-l6l24pco	80	3	that	that	WDT
cord-350992-l6l24pco	80	4	turn	turn	VBP
cord-350992-l6l24pco	80	5	on	on	RP
cord-350992-l6l24pco	80	6	the	the	DT
cord-350992-l6l24pco	80	7	inflammatory	inflammatory	JJ
cord-350992-l6l24pco	80	8	response	response	NN
cord-350992-l6l24pco	80	9	,	,	,
cord-350992-l6l24pco	80	10	but	but	CC
cord-350992-l6l24pco	80	11	this	this	DT
cord-350992-l6l24pco	80	12	reaction	reaction	NN
cord-350992-l6l24pco	80	13	can	can	MD
cord-350992-l6l24pco	80	14	be	be	VB
cord-350992-l6l24pco	80	15	inhibited	inhibit	VBN
cord-350992-l6l24pco	80	16	by	by	IN
cord-350992-l6l24pco	80	17	the	the	DT
cord-350992-l6l24pco	80	18	CQ	CQ	NNP
cord-350992-l6l24pco	80	19	[	[	-LRB-
cord-350992-l6l24pco	80	20	22	22	CD
cord-350992-l6l24pco	80	21	,	,	,
cord-350992-l6l24pco	80	22	23	23	CD
cord-350992-l6l24pco	80	23	]	]	-RRB-
cord-350992-l6l24pco	80	24	.	.	.
cord-350992-l6l24pco	81	1	As	as	IN
cord-350992-l6l24pco	81	2	previously	previously	RB
cord-350992-l6l24pco	81	3	mentioned	mention	VBN
cord-350992-l6l24pco	81	4	,	,	,
cord-350992-l6l24pco	81	5	COVID-19	COVID-19	NNP
cord-350992-l6l24pco	81	6	is	be	VBZ
cord-350992-l6l24pco	81	7	characterized	characterize	VBN
cord-350992-l6l24pco	81	8	by	by	IN
cord-350992-l6l24pco	81	9	the	the	DT
cord-350992-l6l24pco	81	10	release	release	NN
cord-350992-l6l24pco	81	11	of	of	IN
cord-350992-l6l24pco	81	12	high	high	JJ
cord-350992-l6l24pco	81	13	levels	level	NNS
cord-350992-l6l24pco	81	14	of	of	IN
cord-350992-l6l24pco	81	15	IL-6	IL-6	NNP
cord-350992-l6l24pco	81	16	,	,	,
cord-350992-l6l24pco	81	17	IL-1	IL-1	NNP
cord-350992-l6l24pco	81	18	and	and	CC
cord-350992-l6l24pco	81	19	TNF-that	tnf-that	DT
cord-350992-l6l24pco	81	20	arekey	arekey	JJ
cord-350992-l6l24pco	81	21	modulators	modulator	NNS
cord-350992-l6l24pco	81	22	of	of	IN
cord-350992-l6l24pco	81	23	inflammation	inflammation	NN
cord-350992-l6l24pco	82	1	[	[	-LRB-
cord-350992-l6l24pco	82	2	37	37	CD
cord-350992-l6l24pco	82	3	,	,	,
cord-350992-l6l24pco	82	4	38	38	CD
cord-350992-l6l24pco	82	5	]	]	-RRB-
cord-350992-l6l24pco	82	6	.	.	.
cord-350992-l6l24pco	83	1	CQ	CQ	NNP
cord-350992-l6l24pco	83	2	/	/	SYM
cord-350992-l6l24pco	83	3	HCQ	HCQ	NNP
cord-350992-l6l24pco	83	4	have	have	VBP
cord-350992-l6l24pco	83	5	been	be	VBN
cord-350992-l6l24pco	83	6	shown	show	VBN
cord-350992-l6l24pco	83	7	to	to	TO
cord-350992-l6l24pco	83	8	inhibit	inhibit	VB
cord-350992-l6l24pco	83	9	their	-PRON-	PRP$
cord-350992-l6l24pco	83	10	release	release	NN
cord-350992-l6l24pco	83	11	by	by	IN
cord-350992-l6l24pco	83	12	immune	immune	JJ
cord-350992-l6l24pco	83	13	cells	cell	NNS
cord-350992-l6l24pco	83	14	through	through	IN
cord-350992-l6l24pco	83	15	several	several	JJ
cord-350992-l6l24pco	83	16	mechanisms	mechanism	NNS
cord-350992-l6l24pco	83	17	like	like	IN
cord-350992-l6l24pco	83	18	transcription	transcription	NN
cord-350992-l6l24pco	83	19	and	and	CC
cord-350992-l6l24pco	83	20	post	post	JJ
cord-350992-l6l24pco	83	21	-	-	JJ
cord-350992-l6l24pco	83	22	transcriptional	transcriptional	JJ
cord-350992-l6l24pco	83	23	regulation	regulation	NN
cord-350992-l6l24pco	83	24	,	,	,
cord-350992-l6l24pco	83	25	p38	p38	CD
cord-350992-l6l24pco	83	26	MAPK	MAPK	NNP
cord-350992-l6l24pco	83	27	signaling	signal	VBG
cord-350992-l6l24pco	83	28	block	block	NN
cord-350992-l6l24pco	83	29	as	as	IN
cord-350992-l6l24pco	83	30	stated	state	VBN
cord-350992-l6l24pco	83	31	above	above	IN
cord-350992-l6l24pco	83	32	or	or	CC
cord-350992-l6l24pco	83	33	disruption	disruption	NN
cord-350992-l6l24pco	83	34	of	of	IN
cord-350992-l6l24pco	83	35	cellular	cellular	JJ
cord-350992-l6l24pco	83	36	iron	iron	NN
cord-350992-l6l24pco	83	37	metabolism	metabolism	NN
cord-350992-l6l24pco	83	38	among	among	IN
cord-350992-l6l24pco	83	39	others	other	NNS
cord-350992-l6l24pco	83	40	[	[	-LRB-
cord-350992-l6l24pco	83	41	6	6	CD
cord-350992-l6l24pco	83	42	,	,	,
cord-350992-l6l24pco	83	43	[	[	-LRB-
cord-350992-l6l24pco	83	44	39	39	CD
cord-350992-l6l24pco	83	45	]	]	-RRB-
cord-350992-l6l24pco	83	46	[	[	-LRB-
cord-350992-l6l24pco	83	47	40	40	CD
cord-350992-l6l24pco	83	48	]	]	-RRB-
cord-350992-l6l24pco	83	49	[	[	-LRB-
cord-350992-l6l24pco	83	50	41	41	CD
cord-350992-l6l24pco	83	51	]	]	-RRB-
cord-350992-l6l24pco	83	52	[	[	-LRB-
cord-350992-l6l24pco	83	53	42	42	CD
cord-350992-l6l24pco	83	54	]	]	-RRB-
cord-350992-l6l24pco	83	55	[	[	-LRB-
cord-350992-l6l24pco	83	56	43	43	CD
cord-350992-l6l24pco	83	57	]	]	-RRB-
cord-350992-l6l24pco	83	58	[	[	-LRB-
cord-350992-l6l24pco	83	59	44	44	CD
cord-350992-l6l24pco	83	60	]	]	-RRB-
cord-350992-l6l24pco	83	61	[	[	-LRB-
cord-350992-l6l24pco	83	62	45	45	CD
cord-350992-l6l24pco	83	63	]	]	-RRB-
cord-350992-l6l24pco	83	64	[	[	-LRB-
cord-350992-l6l24pco	83	65	46	46	CD
cord-350992-l6l24pco	83	66	]	]	-RRB-
cord-350992-l6l24pco	83	67	[	[	-LRB-
cord-350992-l6l24pco	83	68	47	47	CD
cord-350992-l6l24pco	83	69	]	]	-RRB-
cord-350992-l6l24pco	83	70	.	.	.
cord-350992-l6l24pco	84	1	TNF-	TNF-	NNP
cord-350992-l6l24pco	84	2	is	be	VBZ
cord-350992-l6l24pco	84	3	Then	then	RB
cord-350992-l6l24pco	84	4	,	,	,
cord-350992-l6l24pco	84	5	the	the	DT
cord-350992-l6l24pco	84	6	challenge	challenge	NN
cord-350992-l6l24pco	84	7	for	for	IN
cord-350992-l6l24pco	84	8	anti	anti	JJ
cord-350992-l6l24pco	84	9	-	-	JJ
cord-350992-l6l24pco	84	10	IL-6	il-6	JJ
cord-350992-l6l24pco	84	11	therapy	therapy	NN
cord-350992-l6l24pco	84	12	in	in	IN
cord-350992-l6l24pco	84	13	COVID-19	COVID-19	NNP
cord-350992-l6l24pco	84	14	is	be	VBZ
cord-350992-l6l24pco	84	15	to	to	TO
cord-350992-l6l24pco	84	16	identify	identify	VB
cord-350992-l6l24pco	84	17	when	when	WRB
cord-350992-l6l24pco	84	18	IL-6	IL-6	NNP
cord-350992-l6l24pco	84	19	is	be	VBZ
cord-350992-l6l24pco	84	20	detrimental	detrimental	JJ
cord-350992-l6l24pco	84	21	or	or	CC
cord-350992-l6l24pco	84	22	beneficial	beneficial	JJ
cord-350992-l6l24pco	84	23	that	that	WDT
cord-350992-l6l24pco	84	24	is	be	VBZ
cord-350992-l6l24pco	84	25	when	when	WRB
cord-350992-l6l24pco	84	26	clinicians	clinician	NNS
cord-350992-l6l24pco	84	27	would	would	MD
cord-350992-l6l24pco	84	28	act	act	VB
cord-350992-l6l24pco	84	29	on	on	IN
cord-350992-l6l24pco	84	30	this	this	DT
cord-350992-l6l24pco	84	31	pathway	pathway	NN
cord-350992-l6l24pco	84	32	[	[	-LRB-
cord-350992-l6l24pco	84	33	34	34	CD
cord-350992-l6l24pco	84	34	]	]	-RRB-
cord-350992-l6l24pco	84	35	.	.	.
cord-350992-l6l24pco	85	1	A	a	DT
cord-350992-l6l24pco	85	2	possible	possible	JJ
cord-350992-l6l24pco	85	3	role	role	NN
cord-350992-l6l24pco	85	4	of	of	IN
cord-350992-l6l24pco	85	5	HCQ	HCQ	NNP
cord-350992-l6l24pco	85	6	in	in	IN
cord-350992-l6l24pco	85	7	the	the	DT
cord-350992-l6l24pco	85	8	prevention	prevention	NN
cord-350992-l6l24pco	85	9	of	of	IN
cord-350992-l6l24pco	85	10	thrombosis	thrombosis	NN
cord-350992-l6l24pco	85	11	in	in	IN
cord-350992-l6l24pco	85	12	hip	hip	NN
cord-350992-l6l24pco	85	13	replacement	replacement	NN
cord-350992-l6l24pco	85	14	surgery	surgery	NN
cord-350992-l6l24pco	85	15	has	have	VBZ
cord-350992-l6l24pco	85	16	been	be	VBN
cord-350992-l6l24pco	85	17	proposed	propose	VBN
cord-350992-l6l24pco	85	18	since	since	IN
cord-350992-l6l24pco	85	19	the	the	DT
cord-350992-l6l24pco	85	20	late	late	JJ
cord-350992-l6l24pco	85	21	1970s	1970	NNS
cord-350992-l6l24pco	85	22	[	[	-LRB-
cord-350992-l6l24pco	85	23	57	57	CD
cord-350992-l6l24pco	85	24	-	-	SYM
cord-350992-l6l24pco	85	25	60	60	CD
cord-350992-l6l24pco	85	26	]	]	-RRB-
cord-350992-l6l24pco	85	27	.	.	.
cord-350992-l6l24pco	86	1	In	in	IN
cord-350992-l6l24pco	86	2	this	this	DT
cord-350992-l6l24pco	86	3	pathology	pathology	NN
cord-350992-l6l24pco	86	4	,	,	,
cord-350992-l6l24pco	86	5	a	a	DT
cord-350992-l6l24pco	86	6	decrease	decrease	NN
cord-350992-l6l24pco	86	7	of	of	IN
cord-350992-l6l24pco	86	8	pulmonary	pulmonary	JJ
cord-350992-l6l24pco	86	9	embolism	embolism	NN
cord-350992-l6l24pco	86	10	has	have	VBZ
cord-350992-l6l24pco	86	11	been	be	VBN
cord-350992-l6l24pco	86	12	reported	report	VBN
cord-350992-l6l24pco	86	13	using	use	VBG
cord-350992-l6l24pco	86	14	HCQ	HCQ	NNP
cord-350992-l6l24pco	86	15	doses	dose	NNS
cord-350992-l6l24pco	86	16	between	between	IN
cord-350992-l6l24pco	86	17	600	600	CD
cord-350992-l6l24pco	86	18	and	and	CC
cord-350992-l6l24pco	86	19	1600	1600	CD
cord-350992-l6l24pco	86	20	mg	mg	NN
cord-350992-l6l24pco	86	21	per	per	IN
cord-350992-l6l24pco	86	22	day	day	NN
cord-350992-l6l24pco	86	23	[	[	-LRB-
cord-350992-l6l24pco	86	24	61	61	CD
cord-350992-l6l24pco	86	25	,	,	,
cord-350992-l6l24pco	86	26	62	62	CD
cord-350992-l6l24pco	86	27	]	]	-RRB-
cord-350992-l6l24pco	86	28	.	.	.
cord-350992-l6l24pco	87	1	HCQ	HCQ	NNP
cord-350992-l6l24pco	87	2	is	be	VBZ
cord-350992-l6l24pco	87	3	now	now	RB
cord-350992-l6l24pco	87	4	commonly	commonly	RB
cord-350992-l6l24pco	87	5	used	use	VBN
cord-350992-l6l24pco	87	6	as	as	IN
cord-350992-l6l24pco	87	7	therapeutic	therapeutic	JJ
cord-350992-l6l24pco	87	8	in	in	IN
cord-350992-l6l24pco	87	9	SLE	SLE	NNP
cord-350992-l6l24pco	87	10	and	and	CC
cord-350992-l6l24pco	87	11	J	J	NNP
cord-350992-l6l24pco	87	12	o	o	NN
cord-350992-l6l24pco	87	13	u	u	NN
cord-350992-l6l24pco	87	14	r	r	NN
cord-350992-l6l24pco	87	15	n	n	NN
cord-350992-l6l24pco	87	16	a	a	DT
cord-350992-l6l24pco	87	17	l	l	NN
cord-350992-l6l24pco	87	18	P	p	NN
cord-350992-l6l24pco	87	19	r	r	NN
cord-350992-l6l24pco	87	20	e	e	NN
cord-350992-l6l24pco	88	1	-p	-p	:
cord-350992-l6l24pco	89	1	r	r	NN
cord-350992-l6l24pco	89	2	o	o	NN
cord-350992-l6l24pco	89	3	o	o	NN
cord-350992-l6l24pco	89	4	f	f	NN
cord-350992-l6l24pco	89	5	APS	APS	NNP
cord-350992-l6l24pco	89	6	,	,	,
cord-350992-l6l24pco	89	7	also	also	RB
cord-350992-l6l24pco	89	8	due	due	IN
cord-350992-l6l24pco	89	9	to	to	IN
cord-350992-l6l24pco	89	10	its	-PRON-	PRP$
cord-350992-l6l24pco	89	11	ability	ability	NN
cord-350992-l6l24pco	89	12	to	to	TO
cord-350992-l6l24pco	89	13	decrease	decrease	VB
cord-350992-l6l24pco	89	14	the	the	DT
cord-350992-l6l24pco	89	15	incidence	incidence	NN
cord-350992-l6l24pco	89	16	of	of	IN
cord-350992-l6l24pco	89	17	thrombosis	thrombosis	NN
cord-350992-l6l24pco	89	18	at	at	IN
cord-350992-l6l24pco	89	19	the	the	DT
cord-350992-l6l24pco	89	20	dose	dose	NN
cord-350992-l6l24pco	89	21	of	of	IN
cord-350992-l6l24pco	89	22	200	200	CD
cord-350992-l6l24pco	89	23	mg	mg	NN
cord-350992-l6l24pco	89	24	to	to	IN
cord-350992-l6l24pco	89	25	400	400	CD
cord-350992-l6l24pco	89	26	mg	mg	NN
cord-350992-l6l24pco	89	27	per	per	IN
cord-350992-l6l24pco	89	28	day	day	NN
cord-350992-l6l24pco	89	29	[	[	-LRB-
cord-350992-l6l24pco	89	30	63	63	CD
cord-350992-l6l24pco	89	31	]	]	-RRB-
cord-350992-l6l24pco	89	32	[	[	-LRB-
cord-350992-l6l24pco	89	33	64	64	CD
cord-350992-l6l24pco	89	34	]	]	-RRB-
cord-350992-l6l24pco	89	35	[	[	-LRB-
cord-350992-l6l24pco	89	36	65	65	CD
cord-350992-l6l24pco	89	37	]	]	-RRB-
cord-350992-l6l24pco	89	38	[	[	-LRB-
cord-350992-l6l24pco	89	39	66	66	CD
cord-350992-l6l24pco	89	40	]	]	-RRB-
cord-350992-l6l24pco	89	41	[	[	-LRB-
cord-350992-l6l24pco	89	42	67	67	CD
cord-350992-l6l24pco	89	43	]	]	-RRB-
cord-350992-l6l24pco	89	44	[	[	-LRB-
cord-350992-l6l24pco	89	45	68	68	CD
cord-350992-l6l24pco	89	46	]	]	-RRB-
cord-350992-l6l24pco	89	47	.	.	.
cord-350992-l6l24pco	90	1	Some	some	DT
cord-350992-l6l24pco	90	2	authors	author	NNS
cord-350992-l6l24pco	90	3	associated	associate	VBD
cord-350992-l6l24pco	90	4	this	this	DT
cord-350992-l6l24pco	90	5	anti	anti	JJ
cord-350992-l6l24pco	90	6	-	-	JJ
cord-350992-l6l24pco	90	7	thrombotic	thrombotic	JJ
cord-350992-l6l24pco	90	8	effect	effect	NN
cord-350992-l6l24pco	90	9	to	to	IN
cord-350992-l6l24pco	90	10	the	the	DT
cord-350992-l6l24pco	90	11	decrease	decrease	NN
cord-350992-l6l24pco	90	12	of	of	IN
cord-350992-l6l24pco	90	13	the	the	DT
cord-350992-l6l24pco	90	14	anti	anti	JJ
cord-350992-l6l24pco	90	15	-	-	JJ
cord-350992-l6l24pco	90	16	phospholipid	phospholipid	JJ
cord-350992-l6l24pco	90	17	(	(	-LRB-
cord-350992-l6l24pco	90	18	aPL	aPL	NNP
cord-350992-l6l24pco	90	19	)	)	-RRB-
cord-350992-l6l24pco	90	20	antibody	antibody	NN
cord-350992-l6l24pco	90	21	titers	titer	NNS
cord-350992-l6l24pco	90	22	[	[	-LRB-
cord-350992-l6l24pco	90	23	69	69	CD
cord-350992-l6l24pco	90	24	]	]	-RRB-
cord-350992-l6l24pco	90	25	[	[	-LRB-
cord-350992-l6l24pco	90	26	70	70	CD
cord-350992-l6l24pco	90	27	]	]	-RRB-
cord-350992-l6l24pco	90	28	[	[	-LRB-
cord-350992-l6l24pco	90	29	71	71	CD
cord-350992-l6l24pco	90	30	]	]	-RRB-
cord-350992-l6l24pco	90	31	,	,	,
cord-350992-l6l24pco	90	32	while	while	IN
cord-350992-l6l24pco	90	33	others	other	NNS
cord-350992-l6l24pco	90	34	to	to	IN
cord-350992-l6l24pco	90	35	a	a	DT
cord-350992-l6l24pco	90	36	more	more	RBR
cord-350992-l6l24pco	90	37	general	general	JJ
cord-350992-l6l24pco	90	38	and	and	CC
cord-350992-l6l24pco	90	39	transversal	transversal	JJ
cord-350992-l6l24pco	90	40	contribute	contribute	NN
cord-350992-l6l24pco	90	41	to	to	IN
cord-350992-l6l24pco	90	42	immunomodulatory	immunomodulatory	NNP
cord-350992-l6l24pco	90	43	,	,	,
cord-350992-l6l24pco	90	44	anti	anti	JJ
cord-350992-l6l24pco	90	45	-	-	JJ
cord-350992-l6l24pco	90	46	inflammatory	inflammatory	JJ
cord-350992-l6l24pco	90	47	,	,	,
cord-350992-l6l24pco	90	48	metabolic	metabolic	JJ
cord-350992-l6l24pco	90	49	and	and	CC
cord-350992-l6l24pco	90	50	anti	anti	JJ
cord-350992-l6l24pco	90	51	-	-	JJ
cord-350992-l6l24pco	90	52	thrombotic	thrombotic	JJ
cord-350992-l6l24pco	90	53	effects	effect	NNS
cord-350992-l6l24pco	90	54	[	[	-LRB-
cord-350992-l6l24pco	90	55	25	25	CD
cord-350992-l6l24pco	90	56	,	,	,
cord-350992-l6l24pco	90	57	72	72	CD
cord-350992-l6l24pco	90	58	]	]	-RRB-
cord-350992-l6l24pco	90	59	.	.	.
cord-350992-l6l24pco	91	1	Chinese	chinese	JJ
cord-350992-l6l24pco	91	2	cardiologists	cardiologist	NNS
cord-350992-l6l24pco	91	3	have	have	VBP
cord-350992-l6l24pco	91	4	reported	report	VBN
cord-350992-l6l24pco	91	5	diffuse	diffuse	JJ
cord-350992-l6l24pco	91	6	micro	micro	JJ
cord-350992-l6l24pco	91	7	-	-	JJ
cord-350992-l6l24pco	91	8	vascular	vascular	JJ
cord-350992-l6l24pco	91	9	thrombosis	thrombosis	NN
cord-350992-l6l24pco	91	10	in	in	IN
cord-350992-l6l24pco	91	11	various	various	JJ
cord-350992-l6l24pco	91	12	organs	organ	NNS
cord-350992-l6l24pco	91	13	on	on	IN
cord-350992-l6l24pco	91	14	autopsy	autopsy	JJ
cord-350992-l6l24pco	91	15	examination	examination	NN
cord-350992-l6l24pco	91	16	in	in	IN
cord-350992-l6l24pco	91	17	patients	patient	NNS
cord-350992-l6l24pco	91	18	died	die	VBD
cord-350992-l6l24pco	91	19	for	for	IN
cord-350992-l6l24pco	91	20	COVID-19	COVID-19	NNP
cord-350992-l6l24pco	91	21	,	,	,
cord-350992-l6l24pco	91	22	particularly	particularly	RB
cord-350992-l6l24pco	91	23	in	in	IN
cord-350992-l6l24pco	91	24	the	the	DT
cord-350992-l6l24pco	91	25	lung	lung	NN
cord-350992-l6l24pco	91	26	.	.	.
cord-350992-l6l24pco	92	1	Taking	take	VBG
cord-350992-l6l24pco	92	2	into	into	IN
cord-350992-l6l24pco	92	3	consideration	consideration	NN
cord-350992-l6l24pco	92	4	this	this	DT
cord-350992-l6l24pco	92	5	diffuse	diffuse	JJ
cord-350992-l6l24pco	92	6	thrombosis	thrombosis	NN
cord-350992-l6l24pco	92	7	,	,	,
cord-350992-l6l24pco	92	8	Chinese	chinese	JJ
cord-350992-l6l24pco	92	9	physicians	physician	NNS
cord-350992-l6l24pco	92	10	have	have	VBP
cord-350992-l6l24pco	92	11	recommended	recommend	VBN
cord-350992-l6l24pco	92	12	anti	anti	JJ
cord-350992-l6l24pco	92	13	-	-	JJ
cord-350992-l6l24pco	92	14	coagulant	coagulant	JJ
cord-350992-l6l24pco	92	15	therapy	therapy	NN
cord-350992-l6l24pco	92	16	in	in	IN
cord-350992-l6l24pco	92	17	these	these	DT
cord-350992-l6l24pco	92	18	patients	patient	NNS
cord-350992-l6l24pco	92	19	,	,	,
cord-350992-l6l24pco	92	20	but	but	CC
cord-350992-l6l24pco	92	21	no	no	DT
cord-350992-l6l24pco	92	22	pharmacological	pharmacological	JJ
cord-350992-l6l24pco	92	23	protocols	protocol	NNS
cord-350992-l6l24pco	92	24	have	have	VBP
cord-350992-l6l24pco	92	25	currently	currently	RB
cord-350992-l6l24pco	92	26	been	be	VBN
cord-350992-l6l24pco	92	27	published	publish	VBN
cord-350992-l6l24pco	92	28	[	[	-LRB-
cord-350992-l6l24pco	92	29	73	73	CD
cord-350992-l6l24pco	92	30	]	]	-RRB-
cord-350992-l6l24pco	92	31	.	.	.
cord-350992-l6l24pco	93	1	The	the	DT
cord-350992-l6l24pco	93	2	anti	anti	JJ
cord-350992-l6l24pco	93	3	-	-	JJ
cord-350992-l6l24pco	93	4	thrombotic	thrombotic	JJ
cord-350992-l6l24pco	93	5	effect	effect	NN
cord-350992-l6l24pco	93	6	of	of	IN
cord-350992-l6l24pco	93	7	CQ	CQ	NNP
cord-350992-l6l24pco	93	8	/	/	SYM
cord-350992-l6l24pco	93	9	HCQ	HCQ	NNP
cord-350992-l6l24pco	93	10	may	may	MD
cord-350992-l6l24pco	93	11	derive	derive	VB
cord-350992-l6l24pco	93	12	from	from	IN
cord-350992-l6l24pco	93	13	different	different	JJ
cord-350992-l6l24pco	93	14	mechanisms	mechanism	NNS
cord-350992-l6l24pco	93	15	.	.	.
cord-350992-l6l24pco	94	1	See	see	VB
cord-350992-l6l24pco	94	2	Table	table	NN
cord-350992-l6l24pco	94	3	3	3	CD
cord-350992-l6l24pco	94	4	for	for	IN
cord-350992-l6l24pco	94	5	a	a	DT
cord-350992-l6l24pco	94	6	schematic	schematic	JJ
cord-350992-l6l24pco	94	7	list	list	NN
cord-350992-l6l24pco	94	8	of	of	IN
cord-350992-l6l24pco	94	9	CQ	CQ	NNP
cord-350992-l6l24pco	94	10	/	/	SYM
cord-350992-l6l24pco	94	11	HCQ	HCQ	NNP
cord-350992-l6l24pco	94	12	biological	biological	JJ
cord-350992-l6l24pco	94	13	activities	activity	NNS
cord-350992-l6l24pco	94	14	as	as	IN
cord-350992-l6l24pco	94	15	anti	anti	JJ
cord-350992-l6l24pco	94	16	-	-	JJ
cord-350992-l6l24pco	94	17	thrombotic	thrombotic	JJ
cord-350992-l6l24pco	94	18	drugs	drug	NNS
cord-350992-l6l24pco	94	19	.	.	.
cord-350992-l6l24pco	95	1	CQ	CQ	NNP
cord-350992-l6l24pco	95	2	/	/	SYM
cord-350992-l6l24pco	95	3	HCQ	HCQ	NNP
cord-350992-l6l24pco	95	4	could	could	MD
cord-350992-l6l24pco	95	5	act	act	VB
cord-350992-l6l24pco	95	6	by	by	IN
cord-350992-l6l24pco	95	7	interfering	interfere	VBG
cord-350992-l6l24pco	95	8	with	with	IN
cord-350992-l6l24pco	95	9	platelet	platelet	NN
cord-350992-l6l24pco	95	10	aggregation	aggregation	NN
cord-350992-l6l24pco	95	11	,	,	,
cord-350992-l6l24pco	95	12	decreasing	decrease	VBG
cord-350992-l6l24pco	95	13	the	the	DT
cord-350992-l6l24pco	95	14	activation	activation	NN
cord-350992-l6l24pco	95	15	of	of	IN
cord-350992-l6l24pco	95	16	collagen	collagen	NN
cord-350992-l6l24pco	95	17	and	and	CC
cord-350992-l6l24pco	95	18	alpha	alpha	NN
cord-350992-l6l24pco	95	19	granule	granule	NN
cord-350992-l6l24pco	95	20	discharge	discharge	NN
cord-350992-l6l24pco	95	21	[	[	-LRB-
cord-350992-l6l24pco	95	22	74	74	CD
cord-350992-l6l24pco	95	23	,	,	,
cord-350992-l6l24pco	95	24	75	75	CD
cord-350992-l6l24pco	95	25	]	]	-RRB-
cord-350992-l6l24pco	95	26	.	.	.
cord-350992-l6l24pco	96	1	Platelet	platelet	NN
cord-350992-l6l24pco	96	2	activation	activation	NN
cord-350992-l6l24pco	96	3	induces	induce	VBZ
cord-350992-l6l24pco	96	4	degranulation	degranulation	NN
cord-350992-l6l24pco	96	5	with	with	IN
cord-350992-l6l24pco	96	6	the	the	DT
cord-350992-l6l24pco	96	7	release	release	NN
cord-350992-l6l24pco	96	8	of	of	IN
cord-350992-l6l24pco	96	9	adenine	adenine	NN
cord-350992-l6l24pco	96	10	diphosphate	diphosphate	NN
cord-350992-l6l24pco	96	11	(	(	-LRB-
cord-350992-l6l24pco	96	12	ADP	ADP	NNP
cord-350992-l6l24pco	96	13	)	)	-RRB-
cord-350992-l6l24pco	96	14	and	and	CC
cord-350992-l6l24pco	96	15	other	other	JJ
cord-350992-l6l24pco	96	16	molecules	molecule	NNS
cord-350992-l6l24pco	96	17	in	in	IN
cord-350992-l6l24pco	96	18	order	order	NN
cord-350992-l6l24pco	96	19	to	to	TO
cord-350992-l6l24pco	96	20	amplify	amplify	VB
cord-350992-l6l24pco	96	21	the	the	DT
cord-350992-l6l24pco	96	22	platelet	platelet	NN
cord-350992-l6l24pco	96	23	activation	activation	NN
cord-350992-l6l24pco	96	24	process	process	NN
cord-350992-l6l24pco	96	25	.	.	.
cord-350992-l6l24pco	97	1	HCQ	HCQ	NNP
cord-350992-l6l24pco	97	2	has	have	VBZ
cord-350992-l6l24pco	97	3	been	be	VBN
cord-350992-l6l24pco	97	4	shown	show	VBN
cord-350992-l6l24pco	97	5	to	to	TO
cord-350992-l6l24pco	97	6	decrease	decrease	VB
cord-350992-l6l24pco	97	7	ADP	ADP	NNP
cord-350992-l6l24pco	97	8	effects	effect	NNS
cord-350992-l6l24pco	97	9	on	on	IN
cord-350992-l6l24pco	97	10	platelet	platelet	NN
cord-350992-l6l24pco	97	11	activation	activation	NN
cord-350992-l6l24pco	97	12	and	and	CC
cord-350992-l6l24pco	97	13	in	in	IN
cord-350992-l6l24pco	97	14	vitro	vitro	FW
cord-350992-l6l24pco	97	15	platelet	platelet	NN
cord-350992-l6l24pco	97	16	aggregation	aggregation	NN
cord-350992-l6l24pco	97	17	induced	induce	VBN
cord-350992-l6l24pco	97	18	by	by	IN
cord-350992-l6l24pco	97	19	the	the	DT
cord-350992-l6l24pco	97	20	antibiotic	antibiotic	JJ
cord-350992-l6l24pco	97	21	ristocetin	ristocetin	NN
cord-350992-l6l24pco	97	22	[	[	-LRB-
cord-350992-l6l24pco	97	23	74	74	CD
cord-350992-l6l24pco	97	24	,	,	,
cord-350992-l6l24pco	97	25	76	76	CD
cord-350992-l6l24pco	97	26	]	]	-RRB-
cord-350992-l6l24pco	97	27	.	.	.
cord-350992-l6l24pco	98	1	As	as	IN
cord-350992-l6l24pco	98	2	mentioned	mention	VBN
cord-350992-l6l24pco	98	3	above	above	RB
cord-350992-l6l24pco	98	4	,	,	,
cord-350992-l6l24pco	98	5	CQ	CQ	NNP
cord-350992-l6l24pco	98	6	/	/	SYM
cord-350992-l6l24pco	98	7	HCQ	HCQ	NNP
cord-350992-l6l24pco	98	8	could	could	MD
cord-350992-l6l24pco	98	9	inhibit	inhibit	VB
cord-350992-l6l24pco	98	10	phospholipase	phospholipase	NN
cord-350992-l6l24pco	98	11	A2	a2	NN
cord-350992-l6l24pco	98	12	and	and	CC
cord-350992-l6l24pco	98	13	decrease	decrease	VB
cord-350992-l6l24pco	98	14	arachidonic	arachidonic	NN
cord-350992-l6l24pco	98	15	acid	acid	NN
cord-350992-l6l24pco	98	16	,	,	,
cord-350992-l6l24pco	98	17	prostaglandin	prostaglandin	NN
cord-350992-l6l24pco	98	18	and	and	CC
cord-350992-l6l24pco	98	19	tromboxane	tromboxane	NNP
cord-350992-l6l24pco	98	20	release	release	NNP
cord-350992-l6l24pco	98	21	[	[	-LRB-
cord-350992-l6l24pco	98	22	33	33	CD
cord-350992-l6l24pco	98	23	,	,	,
cord-350992-l6l24pco	98	24	77	77	CD
cord-350992-l6l24pco	98	25	]	]	-RRB-
cord-350992-l6l24pco	98	26	.	.	.
cord-350992-l6l24pco	99	1	When	when	WRB
cord-350992-l6l24pco	99	2	administered	administer	VBN
cord-350992-l6l24pco	99	3	within	within	IN
cord-350992-l6l24pco	99	4	48h	48h	NNS
cord-350992-l6l24pco	99	5	before	before	IN
cord-350992-l6l24pco	99	6	surgery	surgery	NN
cord-350992-l6l24pco	99	7	,	,	,
cord-350992-l6l24pco	99	8	HCQ	HCQ	NNP
cord-350992-l6l24pco	99	9	induces	induce	VBZ
cord-350992-l6l24pco	99	10	the	the	DT
cord-350992-l6l24pco	99	11	increase	increase	NN
cord-350992-l6l24pco	99	12	of	of	IN
cord-350992-l6l24pco	99	13	fibrinogen	fibrinogen	NN
cord-350992-l6l24pco	99	14	causing	cause	VBG
cord-350992-l6l24pco	99	15	a	a	DT
cord-350992-l6l24pco	99	16	decrease	decrease	NN
cord-350992-l6l24pco	99	17	of	of	IN
cord-350992-l6l24pco	99	18	plasmatic	plasmatic	NN
cord-350992-l6l24pco	99	19	and	and	CC
cord-350992-l6l24pco	99	20	blood	blood	NN
cord-350992-l6l24pco	99	21	viscosity	viscosity	NN
cord-350992-l6l24pco	99	22	[	[	-LRB-
cord-350992-l6l24pco	99	23	78	78	CD
cord-350992-l6l24pco	99	24	]	]	-RRB-
cord-350992-l6l24pco	99	25	.	.	.
cord-350992-l6l24pco	100	1	A	a	DT
cord-350992-l6l24pco	100	2	possible	possible	JJ
cord-350992-l6l24pco	100	3	role	role	NN
cord-350992-l6l24pco	100	4	in	in	IN
cord-350992-l6l24pco	100	5	rheological	rheological	JJ
cord-350992-l6l24pco	100	6	property	property	NN
cord-350992-l6l24pco	100	7	decrease	decrease	NN
cord-350992-l6l24pco	100	8	of	of	IN
cord-350992-l6l24pco	100	9	red	red	JJ
cord-350992-l6l24pco	100	10	blood	blood	NN
cord-350992-l6l24pco	100	11	cells	cell	NNS
cord-350992-l6l24pco	100	12	(	(	-LRB-
cord-350992-l6l24pco	100	13	RBCs	rbc	NNS
cord-350992-l6l24pco	100	14	)	)	-RRB-
cord-350992-l6l24pco	100	15	has	have	VBZ
cord-350992-l6l24pco	100	16	been	be	VBN
cord-350992-l6l24pco	100	17	proposed	propose	VBN
cord-350992-l6l24pco	100	18	,	,	,
cord-350992-l6l24pco	100	19	but	but	CC
cord-350992-l6l24pco	100	20	this	this	DT
cord-350992-l6l24pco	100	21	effect	effect	NN
cord-350992-l6l24pco	100	22	is	be	VBZ
cord-350992-l6l24pco	100	23	not	not	RB
cord-350992-l6l24pco	100	24	perfectly	perfectly	RB
cord-350992-l6l24pco	100	25	clarified	clarify	VBN
cord-350992-l6l24pco	100	26	[	[	-LRB-
cord-350992-l6l24pco	100	27	79	79	CD
cord-350992-l6l24pco	100	28	]	]	-RRB-
cord-350992-l6l24pco	100	29	.	.	.
cord-350992-l6l24pco	101	1	Neutrophil	Neutrophil	NNP
cord-350992-l6l24pco	101	2	extracellular	extracellular	JJ
cord-350992-l6l24pco	101	3	traps	trap	NNS
cord-350992-l6l24pco	101	4	(	(	-LRB-
cord-350992-l6l24pco	101	5	NETs	net	NNS
cord-350992-l6l24pco	101	6	)	)	-RRB-
cord-350992-l6l24pco	101	7	are	be	VBP
cord-350992-l6l24pco	101	8	released	release	VBN
cord-350992-l6l24pco	101	9	by	by	IN
cord-350992-l6l24pco	101	10	activated	activate	VBN
cord-350992-l6l24pco	101	11	neutrophils	neutrophil	NNS
cord-350992-l6l24pco	101	12	that	that	WDT
cord-350992-l6l24pco	101	13	unleash	unleash	VBP
cord-350992-l6l24pco	101	14	intracellular	intracellular	JJ
cord-350992-l6l24pco	101	15	molecules	molecule	NNS
cord-350992-l6l24pco	101	16	such	such	JJ
cord-350992-l6l24pco	101	17	as	as	IN
cord-350992-l6l24pco	101	18	granules	granule	NNS
cord-350992-l6l24pco	101	19	,	,	,
cord-350992-l6l24pco	101	20	proteins	protein	NNS
cord-350992-l6l24pco	101	21	,	,	,
cord-350992-l6l24pco	101	22	DNA	dna	NN
cord-350992-l6l24pco	101	23	and	and	CC
cord-350992-l6l24pco	101	24	histones	histone	NNS
cord-350992-l6l24pco	101	25	in	in	IN
cord-350992-l6l24pco	101	26	tissues	tissue	NNS
cord-350992-l6l24pco	101	27	or	or	CC
cord-350992-l6l24pco	101	28	circulation	circulation	NN
cord-350992-l6l24pco	101	29	to	to	TO
cord-350992-l6l24pco	101	30	capture	capture	VB
cord-350992-l6l24pco	101	31	and	and	CC
cord-350992-l6l24pco	101	32	kill	kill	VB
cord-350992-l6l24pco	101	33	pathogens	pathogen	NNS
cord-350992-l6l24pco	101	34	during	during	IN
cord-350992-l6l24pco	101	35	infections	infection	NNS
cord-350992-l6l24pco	101	36	[	[	-LRB-
cord-350992-l6l24pco	101	37	80	80	CD
cord-350992-l6l24pco	101	38	]	]	-RRB-
cord-350992-l6l24pco	101	39	.	.	.
cord-350992-l6l24pco	102	1	NETs	net	NNS
cord-350992-l6l24pco	102	2	have	have	VBP
cord-350992-l6l24pco	102	3	been	be	VBN
cord-350992-l6l24pco	102	4	shown	show	VBN
cord-350992-l6l24pco	102	5	to	to	TO
cord-350992-l6l24pco	102	6	increase	increase	VB
cord-350992-l6l24pco	102	7	thrombosis	thrombosis	NN
cord-350992-l6l24pco	102	8	in	in	IN
cord-350992-l6l24pco	102	9	autoimmune	autoimmune	JJ
cord-350992-l6l24pco	102	10	diseases	disease	NNS
cord-350992-l6l24pco	102	11	and	and	CC
cord-350992-l6l24pco	102	12	in	in	IN
cord-350992-l6l24pco	102	13	inflammation	inflammation	NN
cord-350992-l6l24pco	102	14	[	[	-LRB-
cord-350992-l6l24pco	102	15	81	81	CD
cord-350992-l6l24pco	102	16	,	,	,
cord-350992-l6l24pco	102	17	82	82	CD
cord-350992-l6l24pco	102	18	]	]	-RRB-
cord-350992-l6l24pco	102	19	.	.	.
cord-350992-l6l24pco	103	1	Golonka	Golonka	NNP
cord-350992-l6l24pco	103	2	and	and	CC
cord-350992-l6l24pco	103	3	colleagues	colleague	NNS
cord-350992-l6l24pco	103	4	[	[	-LRB-
cord-350992-l6l24pco	103	5	83	83	CD
cord-350992-l6l24pco	103	6	]	]	-RRB-
cord-350992-l6l24pco	103	7	have	have	VBP
cord-350992-l6l24pco	103	8	recently	recently	RB
cord-350992-l6l24pco	103	9	hypothesized	hypothesize	VBN
cord-350992-l6l24pco	103	10	that	that	IN
cord-350992-l6l24pco	103	11	neutrophil	neutrophil	NN
cord-350992-l6l24pco	103	12	abundance	abundance	NN
cord-350992-l6l24pco	103	13	in	in	IN
cord-350992-l6l24pco	103	14	COVID-19	COVID-19	NNP
cord-350992-l6l24pco	103	15	could	could	MD
cord-350992-l6l24pco	103	16	be	be	VB
cord-350992-l6l24pco	103	17	associated	associate	VBN
cord-350992-l6l24pco	103	18	to	to	IN
cord-350992-l6l24pco	103	19	the	the	DT
cord-350992-l6l24pco	103	20	increase	increase	NN
cord-350992-l6l24pco	103	21	of	of	IN
cord-350992-l6l24pco	103	22	NETs	net	NNS
cord-350992-l6l24pco	103	23	.	.	.
cord-350992-l6l24pco	104	1	In	in	IN
cord-350992-l6l24pco	104	2	a	a	DT
cord-350992-l6l24pco	104	3	murine	murine	JJ
cord-350992-l6l24pco	104	4	model	model	NN
cord-350992-l6l24pco	104	5	of	of	IN
cord-350992-l6l24pco	104	6	pancreatic	pancreatic	JJ
cord-350992-l6l24pco	104	7	adenocarcinoma	adenocarcinoma	NN
cord-350992-l6l24pco	104	8	,	,	,
cord-350992-l6l24pco	104	9	NETs	net	NNS
cord-350992-l6l24pco	104	10	have	have	VBP
cord-350992-l6l24pco	104	11	been	be	VBN
cord-350992-l6l24pco	104	12	shown	show	VBN
cord-350992-l6l24pco	104	13	to	to	TO
cord-350992-l6l24pco	104	14	stimulate	stimulate	VB
cord-350992-l6l24pco	104	15	the	the	DT
cord-350992-l6l24pco	104	16	discharge	discharge	NN
cord-350992-l6l24pco	104	17	of	of	IN
cord-350992-l6l24pco	104	18	tissue	tissue	NN
cord-350992-l6l24pco	104	19	factors	factor	NNS
cord-350992-l6l24pco	104	20	and	and	CC
cord-350992-l6l24pco	104	21	promote	promote	VB
cord-350992-l6l24pco	104	22	platelet	platelet	NN
cord-350992-l6l24pco	104	23	activation	activation	NN
cord-350992-l6l24pco	104	24	and	and	CC
cord-350992-l6l24pco	104	25	aggregation	aggregation	NN
cord-350992-l6l24pco	104	26	.	.	.
cord-350992-l6l24pco	105	1	In	in	IN
cord-350992-l6l24pco	105	2	this	this	DT
cord-350992-l6l24pco	105	3	model	model	NN
cord-350992-l6l24pco	105	4	,	,	,
cord-350992-l6l24pco	105	5	CQ	CQ	NNP
cord-350992-l6l24pco	105	6	/	/	SYM
cord-350992-l6l24pco	105	7	HCQ	HCQ	NNP
cord-350992-l6l24pco	105	8	showed	show	VBD
cord-350992-l6l24pco	105	9	,	,	,
cord-350992-l6l24pco	105	10	besides	besides	IN
cord-350992-l6l24pco	105	11	their	-PRON-	PRP$
cord-350992-l6l24pco	105	12	proper	proper	JJ
cord-350992-l6l24pco	105	13	anti	anti	JJ
cord-350992-l6l24pco	105	14	-	-	JJ
cord-350992-l6l24pco	105	15	thrombotic	thrombotic	JJ
cord-350992-l6l24pco	105	16	characteristics	characteristic	NNS
cord-350992-l6l24pco	105	17	,	,	,
cord-350992-l6l24pco	105	18	the	the	DT
cord-350992-l6l24pco	105	19	ability	ability	NN
cord-350992-l6l24pco	105	20	to	to	TO
cord-350992-l6l24pco	105	21	inhibit	inhibit	VB
cord-350992-l6l24pco	105	22	NETs	net	NNS
cord-350992-l6l24pco	105	23	,	,	,
cord-350992-l6l24pco	105	24	in	in	IN
cord-350992-l6l24pco	105	25	turn	turn	NN
cord-350992-l6l24pco	105	26	further	further	RB
cord-350992-l6l24pco	105	27	decreasing	decrease	VBG
cord-350992-l6l24pco	105	28	hypercoagulability	hypercoagulability	NN
cord-350992-l6l24pco	105	29	[	[	-LRB-
cord-350992-l6l24pco	105	30	84	84	CD
cord-350992-l6l24pco	105	31	]	]	-RRB-
cord-350992-l6l24pco	105	32	.	.	.
cord-350992-l6l24pco	106	1	J	J	NNP
cord-350992-l6l24pco	106	2	o	o	NN
cord-350992-l6l24pco	106	3	u	u	NN
cord-350992-l6l24pco	106	4	r	r	NN
cord-350992-l6l24pco	106	5	n	n	NN
cord-350992-l6l24pco	106	6	a	a	DT
cord-350992-l6l24pco	106	7	l	l	NN
cord-350992-l6l24pco	106	8	P	p	NN
cord-350992-l6l24pco	106	9	r	r	NN
cord-350992-l6l24pco	106	10	e	e	NN
cord-350992-l6l24pco	106	11	-p	-p	NN
cord-350992-l6l24pco	106	12	r	r	NN
cord-350992-l6l24pco	106	13	o	o	NN
cord-350992-l6l24pco	107	1	o	o	UH
cord-350992-l6l24pco	107	2	f	f	NNP
cord-350992-l6l24pco	107	3	HCQ	HCQ	NNP
cord-350992-l6l24pco	107	4	has	have	VBZ
cord-350992-l6l24pco	107	5	been	be	VBN
cord-350992-l6l24pco	107	6	shown	show	VBN
cord-350992-l6l24pco	107	7	to	to	TO
cord-350992-l6l24pco	107	8	inhibit	inhibit	VB
cord-350992-l6l24pco	107	9	the	the	DT
cord-350992-l6l24pco	107	10	binding	binding	NN
cord-350992-l6l24pco	107	11	of	of	IN
cord-350992-l6l24pco	107	12	the	the	DT
cord-350992-l6l24pco	107	13	aPL	aPL	.
cord-350992-l6l24pco	108	1	antibody-2-glicoprotein	antibody-2-glicoprotein	RB
cord-350992-l6l24pco	108	2	I	-PRON-	PRP
cord-350992-l6l24pco	108	3	(	(	-LRB-
cord-350992-l6l24pco	108	4	GPI	GPI	NFP
cord-350992-l6l24pco	108	5	)	)	-RRB-
cord-350992-l6l24pco	109	1	complex	complex	JJ
cord-350992-l6l24pco	109	2	to	to	IN
cord-350992-l6l24pco	109	3	the	the	DT
cord-350992-l6l24pco	109	4	phospholipid	phospholipid	NN
cord-350992-l6l24pco	109	5	bilayer	bilayer	NN
cord-350992-l6l24pco	109	6	,	,	,
cord-350992-l6l24pco	109	7	decreasing	decrease	VBG
cord-350992-l6l24pco	109	8	the	the	DT
cord-350992-l6l24pco	109	9	pro	pro	JJ
cord-350992-l6l24pco	109	10	-	-	JJ
cord-350992-l6l24pco	109	11	thrombotic	thrombotic	JJ
cord-350992-l6l24pco	109	12	effect	effect	NN
cord-350992-l6l24pco	109	13	[	[	-LRB-
cord-350992-l6l24pco	109	14	85	85	CD
cord-350992-l6l24pco	109	15	]	]	-RRB-
cord-350992-l6l24pco	109	16	.	.	.
cord-350992-l6l24pco	110	1	AnnexinA5	AnnexinA5	NNP
cord-350992-l6l24pco	111	1	(	(	-LRB-
cord-350992-l6l24pco	111	2	AnxA5	AnxA5	NNP
cord-350992-l6l24pco	111	3	)	)	-RRB-
cord-350992-l6l24pco	111	4	is	be	VBZ
cord-350992-l6l24pco	111	5	an	an	DT
cord-350992-l6l24pco	111	6	anticoagulant	anticoagulant	JJ
cord-350992-l6l24pco	111	7	protein	protein	NN
cord-350992-l6l24pco	111	8	with	with	IN
cord-350992-l6l24pco	111	9	great	great	JJ
cord-350992-l6l24pco	111	10	affinity	affinity	NN
cord-350992-l6l24pco	111	11	for	for	IN
cord-350992-l6l24pco	111	12	negatively	negatively	RB
cord-350992-l6l24pco	111	13	charged	charge	VBN
cord-350992-l6l24pco	111	14	phospholipids	phospholipid	NNS
cord-350992-l6l24pco	111	15	.	.	.
cord-350992-l6l24pco	112	1	This	this	DT
cord-350992-l6l24pco	112	2	protein	protein	NN
cord-350992-l6l24pco	112	3	forms	form	VBZ
cord-350992-l6l24pco	112	4	a	a	DT
cord-350992-l6l24pco	112	5	2-dimensional	2-dimensional	JJ
cord-350992-l6l24pco	112	6	crystal	crystal	NN
cord-350992-l6l24pco	112	7	over	over	IN
cord-350992-l6l24pco	112	8	membrane	membrane	NN
cord-350992-l6l24pco	112	9	phospholipids	phospholipid	NNS
cord-350992-l6l24pco	112	10	and	and	CC
cord-350992-l6l24pco	112	11	exerts	exert	VBZ
cord-350992-l6l24pco	112	12	its	-PRON-	PRP$
cord-350992-l6l24pco	112	13	potent	potent	JJ
cord-350992-l6l24pco	112	14	anticoagulant	anticoagulant	JJ
cord-350992-l6l24pco	112	15	activity	activity	NN
cord-350992-l6l24pco	112	16	shielding	shield	VBG
cord-350992-l6l24pco	112	17	the	the	DT
cord-350992-l6l24pco	112	18	phospholipid	phospholipid	NN
cord-350992-l6l24pco	112	19	bilayer	bilayer	NN
cord-350992-l6l24pco	112	20	from	from	IN
cord-350992-l6l24pco	112	21	the	the	DT
cord-350992-l6l24pco	112	22	interaction	interaction	NN
cord-350992-l6l24pco	112	23	with	with	IN
cord-350992-l6l24pco	112	24	coagulation	coagulation	NN
cord-350992-l6l24pco	112	25	enzymes	enzyme	NNS
cord-350992-l6l24pco	112	26	[	[	-LRB-
cord-350992-l6l24pco	112	27	86	86	CD
cord-350992-l6l24pco	112	28	]	]	-RRB-
cord-350992-l6l24pco	112	29	.	.	.
cord-350992-l6l24pco	113	1	In	in	IN
cord-350992-l6l24pco	113	2	vitro	vitro	FW
cord-350992-l6l24pco	113	3	experiments	experiment	NNS
cord-350992-l6l24pco	113	4	on	on	IN
cord-350992-l6l24pco	113	5	human	human	JJ
cord-350992-l6l24pco	113	6	umbilical	umbilical	JJ
cord-350992-l6l24pco	113	7	vein	vein	NN
cord-350992-l6l24pco	113	8	endothelial	endothelial	JJ
cord-350992-l6l24pco	113	9	cells	cell	NNS
cord-350992-l6l24pco	113	10	(	(	-LRB-
cord-350992-l6l24pco	113	11	HUVEC	HUVEC	NNP
cord-350992-l6l24pco	113	12	)	)	-RRB-
cord-350992-l6l24pco	113	13	have	have	VBP
cord-350992-l6l24pco	113	14	evidenced	evidence	VBN
cord-350992-l6l24pco	113	15	the	the	DT
cord-350992-l6l24pco	113	16	protective	protective	JJ
cord-350992-l6l24pco	113	17	effect	effect	NN
cord-350992-l6l24pco	113	18	of	of	IN
cord-350992-l6l24pco	113	19	HCQ	HCQ	NNP
cord-350992-l6l24pco	113	20	,	,	,
cord-350992-l6l24pco	113	21	which	which	WDT
cord-350992-l6l24pco	113	22	acts	act	VBZ
cord-350992-l6l24pco	113	23	restoring	restore	VBG
cord-350992-l6l24pco	113	24	the	the	DT
cord-350992-l6l24pco	113	25	AnxA5	AnxA5	NNPS
cord-350992-l6l24pco	113	26	anticoagulant	anticoagulant	JJ
cord-350992-l6l24pco	113	27	shield	shield	NN
cord-350992-l6l24pco	113	28	and	and	CC
cord-350992-l6l24pco	113	29	therefore	therefore	RB
cord-350992-l6l24pco	113	30	prevents	prevent	VBZ
cord-350992-l6l24pco	113	31	the	the	DT
cord-350992-l6l24pco	113	32	beginning	beginning	NN
cord-350992-l6l24pco	113	33	of	of	IN
cord-350992-l6l24pco	113	34	coagulation	coagulation	NN
cord-350992-l6l24pco	113	35	cascade	cascade	NN
cord-350992-l6l24pco	113	36	[	[	-LRB-
cord-350992-l6l24pco	113	37	87	87	CD
cord-350992-l6l24pco	113	38	,	,	,
cord-350992-l6l24pco	113	39	88	88	CD
cord-350992-l6l24pco	113	40	]	]	-RRB-
cord-350992-l6l24pco	113	41	.	.	.
cord-350992-l6l24pco	114	1	HCQ	HCQ	NNP
cord-350992-l6l24pco	114	2	is	be	VBZ
cord-350992-l6l24pco	114	3	used	use	VBN
cord-350992-l6l24pco	114	4	in	in	IN
cord-350992-l6l24pco	114	5	the	the	DT
cord-350992-l6l24pco	114	6	treatment	treatment	NN
cord-350992-l6l24pco	114	7	of	of	IN
cord-350992-l6l24pco	114	8	APS	APS	NNP
cord-350992-l6l24pco	114	9	.	.	.
cord-350992-l6l24pco	115	1	Its	-PRON-	PRP$
cord-350992-l6l24pco	115	2	ability	ability	NN
cord-350992-l6l24pco	115	3	to	to	TO
cord-350992-l6l24pco	115	4	reduce	reduce	VB
cord-350992-l6l24pco	115	5	endothelial	endothelial	JJ
cord-350992-l6l24pco	115	6	dysfunction	dysfunction	NN
cord-350992-l6l24pco	115	7	has	have	VBZ
cord-350992-l6l24pco	115	8	been	be	VBN
cord-350992-l6l24pco	115	9	studied	study	VBN
cord-350992-l6l24pco	115	10	in	in	IN
cord-350992-l6l24pco	115	11	animal	animal	NN
cord-350992-l6l24pco	115	12	models	model	NNS
cord-350992-l6l24pco	115	13	.	.	.
cord-350992-l6l24pco	116	1	Vascular	vascular	JJ
cord-350992-l6l24pco	116	2	reactivity	reactivity	NN
cord-350992-l6l24pco	116	3	has	have	VBZ
cord-350992-l6l24pco	116	4	been	be	VBN
cord-350992-l6l24pco	116	5	studied	study	VBN
cord-350992-l6l24pco	116	6	in	in	IN
cord-350992-l6l24pco	116	7	mice	mouse	NNS
cord-350992-l6l24pco	116	8	injected	inject	VBN
cord-350992-l6l24pco	116	9	for	for	IN
cord-350992-l6l24pco	116	10	three	three	CD
cord-350992-l6l24pco	116	11	weeks	week	NNS
cord-350992-l6l24pco	116	12	with	with	IN
cord-350992-l6l24pco	116	13	aPL	aPL	NNP
cord-350992-l6l24pco	116	14	antibodies	antibody	NNS
cord-350992-l6l24pco	116	15	directed	direct	VBN
cord-350992-l6l24pco	116	16	against	against	IN
cord-350992-l6l24pco	116	17	2GPI	2GPI	NNP
cord-350992-l6l24pco	116	18	to	to	TO
cord-350992-l6l24pco	116	19	induce	induce	VB
cord-350992-l6l24pco	116	20	APS	APS	NNP
cord-350992-l6l24pco	116	21	,	,	,
cord-350992-l6l24pco	116	22	with	with	IN
cord-350992-l6l24pco	116	23	or	or	CC
cord-350992-l6l24pco	116	24	without	without	IN
cord-350992-l6l24pco	116	25	HCQ	HCQ	NNP
cord-350992-l6l24pco	116	26	co	co	NN
cord-350992-l6l24pco	116	27	-	-	NN
cord-350992-l6l24pco	116	28	treatment	treatment	NN
cord-350992-l6l24pco	116	29	.	.	.
cord-350992-l6l24pco	117	1	HCQ	HCQ	NNP
cord-350992-l6l24pco	117	2	improved	improve	VBD
cord-350992-l6l24pco	117	3	endotheliumdependent	endotheliumdependent	JJ
cord-350992-l6l24pco	117	4	dilatation	dilatation	NN
cord-350992-l6l24pco	117	5	by	by	IN
cord-350992-l6l24pco	117	6	the	the	DT
cord-350992-l6l24pco	117	7	amelioration	amelioration	NN
cord-350992-l6l24pco	117	8	of	of	IN
cord-350992-l6l24pco	117	9	NO	no	DT
cord-350992-l6l24pco	117	10	bioavailability	bioavailability	NN
cord-350992-l6l24pco	117	11	and	and	CC
cord-350992-l6l24pco	117	12	by	by	IN
cord-350992-l6l24pco	117	13	the	the	DT
cord-350992-l6l24pco	117	14	decrease	decrease	NN
cord-350992-l6l24pco	117	15	of	of	IN
cord-350992-l6l24pco	117	16	oxidative	oxidative	JJ
cord-350992-l6l24pco	117	17	stress	stress	NN
cord-350992-l6l24pco	117	18	[	[	-LRB-
cord-350992-l6l24pco	117	19	89	89	CD
cord-350992-l6l24pco	117	20	]	]	-RRB-
cord-350992-l6l24pco	117	21	.	.	.
cord-350992-l6l24pco	118	1	In	in	IN
cord-350992-l6l24pco	118	2	another	another	DT
cord-350992-l6l24pco	118	3	study	study	NN
cord-350992-l6l24pco	118	4	,	,	,
cord-350992-l6l24pco	118	5	aPL	aPL	NNP
cord-350992-l6l24pco	118	6	antibodies	antibody	NNS
cord-350992-l6l24pco	118	7	were	be	VBD
cord-350992-l6l24pco	118	8	administered	administer	VBN
cord-350992-l6l24pco	118	9	in	in	IN
cord-350992-l6l24pco	118	10	mice	mouse	NNS
cord-350992-l6l24pco	118	11	and	and	CC
cord-350992-l6l24pco	118	12	in	in	IN
cord-350992-l6l24pco	118	13	human	human	JJ
cord-350992-l6l24pco	118	14	aortic	aortic	JJ
cord-350992-l6l24pco	118	15	endotelial	endotelial	JJ
cord-350992-l6l24pco	118	16	cells	cell	NNS
cord-350992-l6l24pco	118	17	(	(	-LRB-
cord-350992-l6l24pco	118	18	HAEC	HAEC	NNP
cord-350992-l6l24pco	118	19	)	)	-RRB-
cord-350992-l6l24pco	118	20	,	,	,
cord-350992-l6l24pco	118	21	in	in	IN
cord-350992-l6l24pco	118	22	the	the	DT
cord-350992-l6l24pco	118	23	presence	presence	NN
cord-350992-l6l24pco	118	24	or	or	CC
cord-350992-l6l24pco	118	25	absence	absence	NN
cord-350992-l6l24pco	118	26	of	of	IN
cord-350992-l6l24pco	118	27	HCQ	HCQ	NNP
cord-350992-l6l24pco	118	28	,	,	,
cord-350992-l6l24pco	118	29	to	to	TO
cord-350992-l6l24pco	118	30	evaluate	evaluate	VB
cord-350992-l6l24pco	118	31	endothelial	endothelial	JJ
cord-350992-l6l24pco	118	32	function	function	NN
cord-350992-l6l24pco	118	33	and	and	CC
cord-350992-l6l24pco	118	34	endothelial	endothelial	JJ
cord-350992-l6l24pco	118	35	nitric	nitric	NN
cord-350992-l6l24pco	118	36	oxide	oxide	NN
cord-350992-l6l24pco	118	37	synthetase	synthetase	NN
cord-350992-l6l24pco	118	38	(	(	-LRB-
cord-350992-l6l24pco	118	39	eNOS	enos	JJ
cord-350992-l6l24pco	118	40	)	)	-RRB-
cord-350992-l6l24pco	118	41	modulation	modulation	NN
cord-350992-l6l24pco	118	42	.	.	.
cord-350992-l6l24pco	119	1	In	in	IN
cord-350992-l6l24pco	119	2	both	both	DT
cord-350992-l6l24pco	119	3	models	model	NNS
cord-350992-l6l24pco	119	4	,	,	,
cord-350992-l6l24pco	119	5	thrombosis	thrombosis	NN
cord-350992-l6l24pco	119	6	was	be	VBD
cord-350992-l6l24pco	119	7	evaluated	evaluate	VBN
cord-350992-l6l24pco	119	8	by	by	IN
cord-350992-l6l24pco	119	9	thrombin	thrombin	NN
cord-350992-l6l24pco	119	10	generating	generate	VBG
cord-350992-l6l24pco	119	11	time	time	NN
cord-350992-l6l24pco	119	12	(	(	-LRB-
cord-350992-l6l24pco	119	13	TGT	tgt	NN
cord-350992-l6l24pco	119	14	)	)	-RRB-
cord-350992-l6l24pco	119	15	and	and	CC
cord-350992-l6l24pco	119	16	tissue	tissue	NN
cord-350992-l6l24pco	119	17	factor	factor	NN
cord-350992-l6l24pco	119	18	(	(	-LRB-
cord-350992-l6l24pco	119	19	TF	TF	NNP
cord-350992-l6l24pco	119	20	)	)	-RRB-
cord-350992-l6l24pco	119	21	production	production	NN
cord-350992-l6l24pco	119	22	.	.	.
cord-350992-l6l24pco	120	1	aPL	aPL	NNP
cord-350992-l6l24pco	120	2	antibodies	antibody	NNS
cord-350992-l6l24pco	120	3	increased	increase	VBD
cord-350992-l6l24pco	120	4	vascular	vascular	JJ
cord-350992-l6l24pco	120	5	cellular	cellular	JJ
cord-350992-l6l24pco	120	6	adhesion	adhesion	NN
cord-350992-l6l24pco	120	7	molecule	molecule	NN
cord-350992-l6l24pco	120	8	1	1	CD
cord-350992-l6l24pco	120	9	(	(	-LRB-
cord-350992-l6l24pco	120	10	VCAM-1	VCAM-1	NNP
cord-350992-l6l24pco	120	11	)	)	-RRB-
cord-350992-l6l24pco	120	12	expression	expression	NN
cord-350992-l6l24pco	120	13	and	and	CC
cord-350992-l6l24pco	120	14	decreased	decrease	VBD
cord-350992-l6l24pco	120	15	endothelial	endothelial	JJ
cord-350992-l6l24pco	120	16	relaxation	relaxation	NN
cord-350992-l6l24pco	120	17	induced	induce	VBN
cord-350992-l6l24pco	120	18	by	by	IN
cord-350992-l6l24pco	120	19	acetylcholine	acetylcholine	NN
cord-350992-l6l24pco	120	20	in	in	IN
cord-350992-l6l24pco	120	21	HAEC	HAEC	NNP
cord-350992-l6l24pco	120	22	cells	cell	NNS
cord-350992-l6l24pco	120	23	.	.	.
cord-350992-l6l24pco	121	1	In	in	IN
cord-350992-l6l24pco	121	2	mice	mouse	NNS
cord-350992-l6l24pco	121	3	,	,	,
cord-350992-l6l24pco	121	4	aPL	aPL	NNP
cord-350992-l6l24pco	121	5	antibodies	antibody	NNS
cord-350992-l6l24pco	121	6	increased	increase	VBD
cord-350992-l6l24pco	121	7	thrombus	thrombus	NN
cord-350992-l6l24pco	121	8	size	size	NN
cord-350992-l6l24pco	121	9	and	and	CC
cord-350992-l6l24pco	121	10	shortened	shorten	VBD
cord-350992-l6l24pco	121	11	the	the	DT
cord-350992-l6l24pco	121	12	time	time	NN
cord-350992-l6l24pco	121	13	needed	need	VBN
cord-350992-l6l24pco	121	14	to	to	TO
cord-350992-l6l24pco	121	15	generate	generate	VB
cord-350992-l6l24pco	121	16	arterial	arterial	JJ
cord-350992-l6l24pco	121	17	occlusion	occlusion	NN
cord-350992-l6l24pco	121	18	.	.	.
cord-350992-l6l24pco	122	1	TGT	TGT	NNP
cord-350992-l6l24pco	122	2	and	and	CC
cord-350992-l6l24pco	122	3	TF	TF	NNP
cord-350992-l6l24pco	122	4	were	be	VBD
cord-350992-l6l24pco	122	5	increased	increase	VBN
cord-350992-l6l24pco	122	6	in	in	IN
cord-350992-l6l24pco	122	7	both	both	DT
cord-350992-l6l24pco	122	8	models	model	NNS
cord-350992-l6l24pco	122	9	.	.	.
cord-350992-l6l24pco	123	1	HCQ	HCQ	NNP
cord-350992-l6l24pco	123	2	confirmed	confirm	VBD
cord-350992-l6l24pco	123	3	its	-PRON-	PRP$
cord-350992-l6l24pco	123	4	anti	anti	JJ
cord-350992-l6l24pco	123	5	-	-	JJ
cord-350992-l6l24pco	123	6	thrombotic	thrombotic	JJ
cord-350992-l6l24pco	123	7	activity	activity	NN
cord-350992-l6l24pco	123	8	decreasing	decrease	VBG
cord-350992-l6l24pco	123	9	clot	clot	NN
cord-350992-l6l24pco	123	10	formation	formation	NN
cord-350992-l6l24pco	123	11	,	,	,
cord-350992-l6l24pco	123	12	ameliorating	ameliorate	VBG
cord-350992-l6l24pco	123	13	TGT	TGT	NNP
cord-350992-l6l24pco	123	14	and	and	CC
cord-350992-l6l24pco	123	15	improving	improve	VBG
cord-350992-l6l24pco	123	16	endothelial	endothelial	JJ
cord-350992-l6l24pco	123	17	relaxation	relaxation	NN
cord-350992-l6l24pco	123	18	.	.	.
cord-350992-l6l24pco	124	1	In	in	IN
cord-350992-l6l24pco	124	2	addition	addition	NN
cord-350992-l6l24pco	124	3	,	,	,
cord-350992-l6l24pco	124	4	HCQ	HCQ	NNP
cord-350992-l6l24pco	124	5	ameliorated	ameliorate	VBD
cord-350992-l6l24pco	124	6	eNOS	enos	JJ
cord-350992-l6l24pco	124	7	activation	activation	NN
cord-350992-l6l24pco	124	8	,	,	,
cord-350992-l6l24pco	124	9	increasing	increase	VBG
cord-350992-l6l24pco	124	10	the	the	DT
cord-350992-l6l24pco	124	11	p	p	NN
cord-350992-l6l24pco	124	12	-	-	HYPH
cord-350992-l6l24pco	124	13	eNOS	enos	JJ
cord-350992-l6l24pco	124	14	/	/	SYM
cord-350992-l6l24pco	124	15	eNOS	enos	JJ
cord-350992-l6l24pco	124	16	ratio	ratio	NN
cord-350992-l6l24pco	124	17	with	with	IN
cord-350992-l6l24pco	124	18	consequent	consequent	JJ
cord-350992-l6l24pco	124	19	improvement	improvement	NN
cord-350992-l6l24pco	124	20	of	of	IN
cord-350992-l6l24pco	124	21	nitric	nitric	NN
cord-350992-l6l24pco	124	22	oxide	oxide	NN
cord-350992-l6l24pco	124	23	(	(	-LRB-
cord-350992-l6l24pco	124	24	NO	no	UH
cord-350992-l6l24pco	124	25	)	)	-RRB-
cord-350992-l6l24pco	124	26	production	production	NN
cord-350992-l6l24pco	124	27	[	[	-LRB-
cord-350992-l6l24pco	124	28	90	90	CD
cord-350992-l6l24pco	124	29	]	]	-RRB-
cord-350992-l6l24pco	124	30	.	.	.
cord-350992-l6l24pco	125	1	Cytokines	cytokine	NNS
cord-350992-l6l24pco	125	2	like	like	IN
cord-350992-l6l24pco	125	3	TNF-	TNF-	NNP
cord-350992-l6l24pco	125	4	,	,	,
cord-350992-l6l24pco	125	5	IL-1	IL-1	NNP
cord-350992-l6l24pco	125	6	and	and	CC
cord-350992-l6l24pco	125	7	aPL	aPL	NNP
cord-350992-l6l24pco	125	8	antibodies	antibody	NNS
cord-350992-l6l24pco	125	9	induce	induce	VBP
cord-350992-l6l24pco	125	10	endosomal	endosomal	NNP
cord-350992-l6l24pco	125	11	NADPH	NADPH	NNP
cord-350992-l6l24pco	125	12	oxidase	oxidase	NN
cord-350992-l6l24pco	125	13	(	(	-LRB-
cord-350992-l6l24pco	125	14	eNOX	enox	UH
cord-350992-l6l24pco	125	15	)	)	-RRB-
cord-350992-l6l24pco	125	16	that	that	WDT
cord-350992-l6l24pco	125	17	is	be	VBZ
cord-350992-l6l24pco	125	18	implicated	implicate	VBN
cord-350992-l6l24pco	125	19	in	in	IN
cord-350992-l6l24pco	125	20	the	the	DT
cord-350992-l6l24pco	125	21	pro	pro	JJ
cord-350992-l6l24pco	125	22	-	-	JJ
cord-350992-l6l24pco	125	23	inflammatory	inflammatory	JJ
cord-350992-l6l24pco	125	24	signal	signal	NN
cord-350992-l6l24pco	125	25	transduction	transduction	NN
cord-350992-l6l24pco	125	26	.	.	.
cord-350992-l6l24pco	126	1	HCQ	HCQ	NNP
cord-350992-l6l24pco	126	2	inhibits	inhibit	VBZ
cord-350992-l6l24pco	126	3	these	these	DT
cord-350992-l6l24pco	126	4	up	up	JJ
cord-350992-l6l24pco	126	5	-	-	HYPH
cord-350992-l6l24pco	126	6	regulation	regulation	NN
cord-350992-l6l24pco	126	7	in	in	IN
cord-350992-l6l24pco	126	8	human	human	JJ
cord-350992-l6l24pco	126	9	monocytes	monocyte	NNS
cord-350992-l6l24pco	126	10	,	,	,
cord-350992-l6l24pco	126	11	preventing	prevent	VBG
cord-350992-l6l24pco	126	12	the	the	DT
cord-350992-l6l24pco	126	13	translocation	translocation	NN
cord-350992-l6l24pco	126	14	of	of	IN
cord-350992-l6l24pco	126	15	the	the	DT
cord-350992-l6l24pco	126	16	catalytic	catalytic	JJ
cord-350992-l6l24pco	126	17	subunit	subunit	NN
cord-350992-l6l24pco	126	18	gp91phox	gp91phox	NN
cord-350992-l6l24pco	126	19	in	in	IN
cord-350992-l6l24pco	126	20	the	the	DT
cord-350992-l6l24pco	126	21	endosome	endosome	NN
cord-350992-l6l24pco	126	22	and	and	CC
cord-350992-l6l24pco	126	23	so	so	RB
cord-350992-l6l24pco	126	24	interfering	interfere	VBG
cord-350992-l6l24pco	126	25	with	with	IN
cord-350992-l6l24pco	126	26	eNOX	enox	NN
cord-350992-l6l24pco	126	27	functions	function	NNS
cord-350992-l6l24pco	126	28	.	.	.
cord-350992-l6l24pco	127	1	Further	further	RB
cord-350992-l6l24pco	127	2	,	,	,
cord-350992-l6l24pco	127	3	HCQ	HCQ	NNP
cord-350992-l6l24pco	127	4	decreases	decrease	VBZ
cord-350992-l6l24pco	127	5	the	the	DT
cord-350992-l6l24pco	127	6	thrombotic	thrombotic	JJ
cord-350992-l6l24pco	127	7	effect	effect	NN
cord-350992-l6l24pco	127	8	induced	induce	VBN
cord-350992-l6l24pco	127	9	by	by	IN
cord-350992-l6l24pco	127	10	aPL	aPL	NNP
cord-350992-l6l24pco	127	11	antibodies	antibody	NNS
cord-350992-l6l24pco	127	12	by	by	IN
cord-350992-l6l24pco	127	13	inhibiting	inhibit	VBG
cord-350992-l6l24pco	127	14	NDAPH	NDAPH	NNP
cord-350992-l6l24pco	127	15	oxidase	oxidase	NN
cord-350992-l6l24pco	127	16	2	2	CD
cord-350992-l6l24pco	127	17	(	(	-LRB-
cord-350992-l6l24pco	127	18	NOX2	NOX2	NNP
cord-350992-l6l24pco	127	19	)	)	-RRB-
cord-350992-l6l24pco	127	20	,	,	,
cord-350992-l6l24pco	127	21	the	the	DT
cord-350992-l6l24pco	127	22	NADPH	NADPH	NNP
cord-350992-l6l24pco	127	23	oxidase	oxidase	NN
cord-350992-l6l24pco	127	24	platelet	platelet	NN
cord-350992-l6l24pco	127	25	isoform	isoform	NN
cord-350992-l6l24pco	127	26	that	that	WDT
cord-350992-l6l24pco	127	27	is	be	VBZ
cord-350992-l6l24pco	127	28	involved	involve	VBN
cord-350992-l6l24pco	127	29	in	in	IN
cord-350992-l6l24pco	127	30	platelet	platelet	NN
cord-350992-l6l24pco	127	31	activation	activation	NN
cord-350992-l6l24pco	127	32	[	[	-LRB-
cord-350992-l6l24pco	127	33	91	91	CD
cord-350992-l6l24pco	127	34	]	]	-RRB-
cord-350992-l6l24pco	127	35	.	.	.
cord-350992-l6l24pco	128	1	An	an	DT
cord-350992-l6l24pco	128	2	additional	additional	JJ
cord-350992-l6l24pco	128	3	indirect	indirect	JJ
cord-350992-l6l24pco	128	4	effect	effect	NN
cord-350992-l6l24pco	128	5	of	of	IN
cord-350992-l6l24pco	128	6	HCQ	HCQ	NNP
cord-350992-l6l24pco	128	7	on	on	IN
cord-350992-l6l24pco	128	8	thrombosis	thrombosis	NN
cord-350992-l6l24pco	128	9	is	be	VBZ
cord-350992-l6l24pco	128	10	its	-PRON-	PRP$
cord-350992-l6l24pco	128	11	ability	ability	NN
cord-350992-l6l24pco	128	12	to	to	TO
cord-350992-l6l24pco	128	13	improve	improve	VB
cord-350992-l6l24pco	128	14	blood	blood	NN
cord-350992-l6l24pco	128	15	lipid	lipid	NN
cord-350992-l6l24pco	128	16	profile	profile	NN
cord-350992-l6l24pco	128	17	.	.	.
cord-350992-l6l24pco	129	1	Studies	study	NNS
cord-350992-l6l24pco	129	2	in	in	IN
cord-350992-l6l24pco	129	3	SLE	SLE	NNP
cord-350992-l6l24pco	129	4	and	and	CC
cord-350992-l6l24pco	129	5	RA	RA	NNP
cord-350992-l6l24pco	129	6	patients	patient	NNS
cord-350992-l6l24pco	129	7	treated	treat	VBN
cord-350992-l6l24pco	129	8	with	with	IN
cord-350992-l6l24pco	129	9	steroids	steroid	NNS
cord-350992-l6l24pco	129	10	have	have	VBP
cord-350992-l6l24pco	129	11	evidenced	evidence	VBN
cord-350992-l6l24pco	129	12	lower	low	JJR
cord-350992-l6l24pco	129	13	LDL	ldl	NN
cord-350992-l6l24pco	129	14	cholesterol	cholesterol	NN
cord-350992-l6l24pco	129	15	and	and	CC
cord-350992-l6l24pco	129	16	triglyceride	triglyceride	NN
cord-350992-l6l24pco	129	17	levels	level	NNS
cord-350992-l6l24pco	129	18	[	[	-LRB-
cord-350992-l6l24pco	129	19	92	92	CD
cord-350992-l6l24pco	129	20	]	]	-RRB-
cord-350992-l6l24pco	129	21	.	.	.
cord-350992-l6l24pco	130	1	These	these	DT
cord-350992-l6l24pco	130	2	data	datum	NNS
cord-350992-l6l24pco	130	3	were	be	VBD
cord-350992-l6l24pco	130	4	confirmed	confirm	VBN
cord-350992-l6l24pco	130	5	in	in	IN
cord-350992-l6l24pco	130	6	further	further	JJ
cord-350992-l6l24pco	130	7	SLE	SLE	NNP
cord-350992-l6l24pco	130	8	cohorts	cohort	NNS
cord-350992-l6l24pco	130	9	treated	treat	VBN
cord-350992-l6l24pco	130	10	with	with	IN
cord-350992-l6l24pco	130	11	HCQ	HCQ	NNP
cord-350992-l6l24pco	130	12	in	in	IN
cord-350992-l6l24pco	130	13	association	association	NN
cord-350992-l6l24pco	130	14	with	with	IN
cord-350992-l6l24pco	130	15	steroids	steroid	NNS
cord-350992-l6l24pco	130	16	:	:	:
cord-350992-l6l24pco	130	17	the	the	DT
cord-350992-l6l24pco	130	18	treatment	treatment	NN
cord-350992-l6l24pco	130	19	decreased	decrease	VBD
cord-350992-l6l24pco	130	20	total	total	JJ
cord-350992-l6l24pco	130	21	cholesterol	cholesterol	NN
cord-350992-l6l24pco	130	22	and	and	CC
cord-350992-l6l24pco	130	23	VLDL	VLDL	NNP
cord-350992-l6l24pco	130	24	level	level	NN
cord-350992-l6l24pco	130	25	and	and	CC
cord-350992-l6l24pco	130	26	increased	increase	VBD
cord-350992-l6l24pco	130	27	HDL	hdl	NN
cord-350992-l6l24pco	130	28	cholesterol	cholesterol	NN
cord-350992-l6l24pco	130	29	[	[	-LRB-
cord-350992-l6l24pco	130	30	93	93	CD
cord-350992-l6l24pco	130	31	,	,	,
cord-350992-l6l24pco	130	32	94	94	CD
cord-350992-l6l24pco	130	33	]	]	-RRB-
cord-350992-l6l24pco	130	34	.	.	.
cord-350992-l6l24pco	131	1	Iron	iron	NN
cord-350992-l6l24pco	131	2	is	be	VBZ
cord-350992-l6l24pco	131	3	an	an	DT
cord-350992-l6l24pco	131	4	essential	essential	JJ
cord-350992-l6l24pco	131	5	element	element	NN
cord-350992-l6l24pco	131	6	for	for	IN
cord-350992-l6l24pco	131	7	all	all	DT
cord-350992-l6l24pco	131	8	organisms	organism	NNS
cord-350992-l6l24pco	131	9	.	.	.
cord-350992-l6l24pco	132	1	This	this	DT
cord-350992-l6l24pco	132	2	is	be	VBZ
cord-350992-l6l24pco	132	3	due	due	JJ
cord-350992-l6l24pco	132	4	to	to	IN
cord-350992-l6l24pco	132	5	its	-PRON-	PRP$
cord-350992-l6l24pco	132	6	redox	redox	NN
cord-350992-l6l24pco	132	7	potential	potential	NN
cord-350992-l6l24pco	132	8	which	which	WDT
cord-350992-l6l24pco	132	9	makes	make	VBZ
cord-350992-l6l24pco	132	10	it	-PRON-	PRP
cord-350992-l6l24pco	132	11	an	an	DT
cord-350992-l6l24pco	132	12	essential	essential	JJ
cord-350992-l6l24pco	132	13	cofactor	cofactor	NN
cord-350992-l6l24pco	132	14	for	for	IN
cord-350992-l6l24pco	132	15	several	several	JJ
cord-350992-l6l24pco	132	16	proteins	protein	NNS
cord-350992-l6l24pco	132	17	and	and	CC
cord-350992-l6l24pco	132	18	enzymes	enzyme	NNS
cord-350992-l6l24pco	132	19	involved	involve	VBN
cord-350992-l6l24pco	132	20	in	in	IN
cord-350992-l6l24pco	132	21	vital	vital	JJ
cord-350992-l6l24pco	132	22	cellular	cellular	JJ
cord-350992-l6l24pco	132	23	functions	function	NNS
cord-350992-l6l24pco	132	24	like	like	IN
cord-350992-l6l24pco	132	25	energy	energy	NN
cord-350992-l6l24pco	132	26	production	production	NN
cord-350992-l6l24pco	132	27	,	,	,
cord-350992-l6l24pco	132	28	DNA	dna	NN
cord-350992-l6l24pco	132	29	replication	replication	NN
cord-350992-l6l24pco	132	30	and	and	CC
cord-350992-l6l24pco	132	31	transcription	transcription	NN
cord-350992-l6l24pco	132	32	.	.	.
cord-350992-l6l24pco	133	1	Even	even	RB
cord-350992-l6l24pco	133	2	most	most	JJS
cord-350992-l6l24pco	133	3	viruses	virus	NNS
cord-350992-l6l24pco	133	4	need	need	VBP
cord-350992-l6l24pco	133	5	iron	iron	NN
cord-350992-l6l24pco	133	6	,	,	,
cord-350992-l6l24pco	133	7	since	since	IN
cord-350992-l6l24pco	133	8	they	-PRON-	PRP
cord-350992-l6l24pco	133	9	require	require	VBP
cord-350992-l6l24pco	133	10	the	the	DT
cord-350992-l6l24pco	133	11	host	host	NN
cord-350992-l6l24pco	133	12	metabolic	metabolic	JJ
cord-350992-l6l24pco	133	13	apparatus	apparatus	NN
cord-350992-l6l24pco	133	14	to	to	TO
cord-350992-l6l24pco	133	15	replicate	replicate	VB
cord-350992-l6l24pco	133	16	their	-PRON-	PRP$
cord-350992-l6l24pco	133	17	genome	genome	NN
cord-350992-l6l24pco	133	18	and	and	CC
cord-350992-l6l24pco	133	19	produce	produce	VB
cord-350992-l6l24pco	133	20	mRNAs	mrna	NNS
cord-350992-l6l24pco	133	21	for	for	IN
cord-350992-l6l24pco	133	22	their	-PRON-	PRP$
cord-350992-l6l24pco	133	23	translation	translation	NN
cord-350992-l6l24pco	133	24	in	in	IN
cord-350992-l6l24pco	133	25	functional	functional	JJ
cord-350992-l6l24pco	133	26	viral	viral	JJ
cord-350992-l6l24pco	133	27	proteins	protein	NNS
cord-350992-l6l24pco	133	28	[	[	-LRB-
cord-350992-l6l24pco	133	29	2	2	CD
cord-350992-l6l24pco	133	30	]	]	-RRB-
cord-350992-l6l24pco	133	31	.	.	.
cord-350992-l6l24pco	134	1	Therefore	therefore	RB
cord-350992-l6l24pco	134	2	,	,	,
cord-350992-l6l24pco	134	3	while	while	IN
cord-350992-l6l24pco	134	4	cellular	cellular	JJ
cord-350992-l6l24pco	134	5	iron	iron	NN
cord-350992-l6l24pco	134	6	repletion	repletion	NN
cord-350992-l6l24pco	134	7	may	may	MD
cord-350992-l6l24pco	134	8	boost	boost	VB
cord-350992-l6l24pco	134	9	viral	viral	JJ
cord-350992-l6l24pco	134	10	replication	replication	NN
cord-350992-l6l24pco	134	11	and	and	CC
cord-350992-l6l24pco	134	12	spread	spread	NN
cord-350992-l6l24pco	134	13	,	,	,
cord-350992-l6l24pco	134	14	iron	iron	NN
cord-350992-l6l24pco	134	15	deficiency	deficiency	NN
cord-350992-l6l24pco	134	16	may	may	MD
cord-350992-l6l24pco	134	17	interfere	interfere	VB
cord-350992-l6l24pco	134	18	with	with	IN
cord-350992-l6l24pco	134	19	viral	viral	JJ
cord-350992-l6l24pco	134	20	life	life	NN
cord-350992-l6l24pco	134	21	cycle	cycle	NN
cord-350992-l6l24pco	134	22	.	.	.
cord-350992-l6l24pco	135	1	During	during	IN
cord-350992-l6l24pco	135	2	infections	infection	NNS
cord-350992-l6l24pco	135	3	and	and	CC
cord-350992-l6l24pco	135	4	inflammation	inflammation	NN
cord-350992-l6l24pco	135	5	,	,	,
cord-350992-l6l24pco	135	6	anemia	anemia	NN
cord-350992-l6l24pco	135	7	is	be	VBZ
cord-350992-l6l24pco	135	8	frequently	frequently	RB
cord-350992-l6l24pco	135	9	observed	observe	VBN
cord-350992-l6l24pco	135	10	and	and	CC
cord-350992-l6l24pco	135	11	caused	cause	VBN
cord-350992-l6l24pco	135	12	by	by	IN
cord-350992-l6l24pco	135	13	pro	pro	JJ
cord-350992-l6l24pco	135	14	-	-	JJ
cord-350992-l6l24pco	135	15	inflammatory	inflammatory	JJ
cord-350992-l6l24pco	135	16	cytokines	cytokine	NNS
cord-350992-l6l24pco	135	17	.	.	.
cord-350992-l6l24pco	136	1	Some	some	DT
cord-350992-l6l24pco	136	2	of	of	IN
cord-350992-l6l24pco	136	3	them	-PRON-	PRP
cord-350992-l6l24pco	136	4	directly	directly	RB
cord-350992-l6l24pco	136	5	affect	affect	VBP
cord-350992-l6l24pco	136	6	iron	iron	NN
cord-350992-l6l24pco	136	7	homeostasis	homeostasis	NN
cord-350992-l6l24pco	136	8	,	,	,
cord-350992-l6l24pco	136	9	like	like	IN
cord-350992-l6l24pco	136	10	IL-1	IL-1	NNP
cord-350992-l6l24pco	136	11	,	,	,
cord-350992-l6l24pco	136	12	TNF-and	TNF-and	NNP
cord-350992-l6l24pco	136	13	IL-6	IL-6	NNP
cord-350992-l6l24pco	136	14	.	.	.
cord-350992-l6l24pco	137	1	The	the	DT
cord-350992-l6l24pco	137	2	release	release	NN
cord-350992-l6l24pco	137	3	of	of	IN
cord-350992-l6l24pco	137	4	these	these	DT
cord-350992-l6l24pco	137	5	cytokines	cytokine	NNS
cord-350992-l6l24pco	137	6	,	,	,
cord-350992-l6l24pco	137	7	mainly	mainly	RB
cord-350992-l6l24pco	137	8	IL-6	IL-6	NNP
cord-350992-l6l24pco	137	9	,	,	,
cord-350992-l6l24pco	137	10	results	result	VBZ
cord-350992-l6l24pco	137	11	in	in	IN
cord-350992-l6l24pco	137	12	the	the	DT
cord-350992-l6l24pco	137	13	upregulation	upregulation	NN
cord-350992-l6l24pco	137	14	of	of	IN
cord-350992-l6l24pco	137	15	the	the	DT
cord-350992-l6l24pco	137	16	iron	iron	NN
cord-350992-l6l24pco	137	17	-	-	HYPH
cord-350992-l6l24pco	137	18	regulatory	regulatory	JJ
cord-350992-l6l24pco	137	19	hormone	hormone	NN
cord-350992-l6l24pco	137	20	hepcidin	hepcidin	NNP
cord-350992-l6l24pco	137	21	(	(	-LRB-
cord-350992-l6l24pco	137	22	HAMP	HAMP	NNP
cord-350992-l6l24pco	137	23	)	)	-RRB-
cord-350992-l6l24pco	137	24	,	,	,
cord-350992-l6l24pco	137	25	primarily	primarily	RB
cord-350992-l6l24pco	137	26	produced	produce	VBN
cord-350992-l6l24pco	137	27	by	by	IN
cord-350992-l6l24pco	137	28	hepatocytes	hepatocyte	NNS
cord-350992-l6l24pco	137	29	and	and	CC
cord-350992-l6l24pco	137	30	released	release	VBN
cord-350992-l6l24pco	137	31	in	in	IN
cord-350992-l6l24pco	137	32	the	the	DT
cord-350992-l6l24pco	137	33	blood	blood	NN
cord-350992-l6l24pco	137	34	flow	flow	NN
cord-350992-l6l24pco	137	35	to	to	TO
cord-350992-l6l24pco	137	36	regulate	regulate	VB
cord-350992-l6l24pco	137	37	systemic	systemic	JJ
cord-350992-l6l24pco	137	38	iron	iron	NN
cord-350992-l6l24pco	137	39	homeostasis	homeostasis	NN
cord-350992-l6l24pco	137	40	.	.	.
cord-350992-l6l24pco	138	1	Systemic	systemic	JJ
cord-350992-l6l24pco	138	2	HAMP	HAMP	NNP
cord-350992-l6l24pco	138	3	blocks	block	VBZ
cord-350992-l6l24pco	138	4	cellular	cellular	JJ
cord-350992-l6l24pco	138	5	iron	iron	NN
cord-350992-l6l24pco	138	6	export	export	NN
cord-350992-l6l24pco	138	7	through	through	IN
cord-350992-l6l24pco	138	8	ferroportin	ferroportin	NNP
cord-350992-l6l24pco	138	9	1	1	CD
cord-350992-l6l24pco	138	10	(	(	-LRB-
cord-350992-l6l24pco	138	11	FPN1	FPN1	NNP
cord-350992-l6l24pco	138	12	)	)	-RRB-
cord-350992-l6l24pco	138	13	,	,	,
cord-350992-l6l24pco	138	14	resulting	result	VBG
cord-350992-l6l24pco	138	15	in	in	IN
cord-350992-l6l24pco	138	16	reduced	reduce	VBN
cord-350992-l6l24pco	138	17	intestinal	intestinal	JJ
cord-350992-l6l24pco	138	18	iron	iron	NN
cord-350992-l6l24pco	138	19	absorption	absorption	NN
cord-350992-l6l24pco	138	20	,	,	,
cord-350992-l6l24pco	138	21	increased	increase	VBN
cord-350992-l6l24pco	138	22	iron	iron	NN
cord-350992-l6l24pco	138	23	retention	retention	NN
cord-350992-l6l24pco	138	24	in	in	IN
cord-350992-l6l24pco	138	25	hepatocytes	hepatocyte	NNS
cord-350992-l6l24pco	138	26	and	and	CC
cord-350992-l6l24pco	138	27	macrophages	macrophage	NNS
cord-350992-l6l24pco	138	28	and	and	CC
cord-350992-l6l24pco	138	29	ultimately	ultimately	RB
cord-350992-l6l24pco	138	30	anemia	anemia	NN
cord-350992-l6l24pco	138	31	of	of	IN
cord-350992-l6l24pco	138	32	infection	infection	NN
cord-350992-l6l24pco	139	1	/inflammation	/inflammation	NNP
cord-350992-l6l24pco	139	2	[	[	-LRB-
cord-350992-l6l24pco	139	3	4	4	CD
cord-350992-l6l24pco	139	4	,	,	,
cord-350992-l6l24pco	139	5	95	95	CD
cord-350992-l6l24pco	139	6	]	]	-RRB-
cord-350992-l6l24pco	139	7	.	.	.
cord-350992-l6l24pco	140	1	Several	several	JJ
cord-350992-l6l24pco	140	2	cells	cell	NNS
cord-350992-l6l24pco	140	3	other	other	JJ
cord-350992-l6l24pco	140	4	than	than	IN
cord-350992-l6l24pco	140	5	hepatocytes	hepatocyte	NNS
cord-350992-l6l24pco	140	6	have	have	VBP
cord-350992-l6l24pco	140	7	been	be	VBN
cord-350992-l6l24pco	140	8	demonstrated	demonstrate	VBN
cord-350992-l6l24pco	140	9	to	to	TO
cord-350992-l6l24pco	140	10	produce	produce	VB
cord-350992-l6l24pco	140	11	and	and	CC
cord-350992-l6l24pco	140	12	release	release	VB
cord-350992-l6l24pco	140	13	HAMP	HAMP	NNP
cord-350992-l6l24pco	140	14	that	that	WDT
cord-350992-l6l24pco	140	15	can	can	MD
cord-350992-l6l24pco	140	16	act	act	VB
cord-350992-l6l24pco	140	17	as	as	IN
cord-350992-l6l24pco	140	18	autocrine	autocrine	JJ
cord-350992-l6l24pco	140	19	and	and	CC
cord-350992-l6l24pco	140	20	paracrine	paracrine	JJ
cord-350992-l6l24pco	140	21	molecule	molecule	NN
cord-350992-l6l24pco	140	22	,	,	,
cord-350992-l6l24pco	140	23	modulating	modulate	VBG
cord-350992-l6l24pco	140	24	local	local	JJ
cord-350992-l6l24pco	140	25	iron	iron	NN
cord-350992-l6l24pco	140	26	homeostasis	homeostasis	NN
cord-350992-l6l24pco	140	27	[	[	-LRB-
cord-350992-l6l24pco	140	28	95	95	CD
cord-350992-l6l24pco	140	29	,	,	,
cord-350992-l6l24pco	140	30	96	96	CD
cord-350992-l6l24pco	140	31	]	]	-RRB-
cord-350992-l6l24pco	140	32	.	.	.
cord-350992-l6l24pco	141	1	Not	not	RB
cord-350992-l6l24pco	141	2	only	only	RB
cord-350992-l6l24pco	141	3	cells	cell	NNS
cord-350992-l6l24pco	141	4	of	of	IN
cord-350992-l6l24pco	141	5	the	the	DT
cord-350992-l6l24pco	141	6	immune	immune	JJ
cord-350992-l6l24pco	141	7	system	system	NN
cord-350992-l6l24pco	141	8	like	like	IN
cord-350992-l6l24pco	141	9	lymphocytes	lymphocyte	NNS
cord-350992-l6l24pco	141	10	,	,	,
cord-350992-l6l24pco	141	11	monocytes	monocyte	NNS
cord-350992-l6l24pco	141	12	and	and	CC
cord-350992-l6l24pco	141	13	macrophages	macrophage	NNS
cord-350992-l6l24pco	141	14	(	(	-LRB-
cord-350992-l6l24pco	141	15	including	include	VBG
cord-350992-l6l24pco	141	16	alveolar	alveolar	JJ
cord-350992-l6l24pco	141	17	macrophages	macrophage	NNS
cord-350992-l6l24pco	141	18	)	)	-RRB-
cord-350992-l6l24pco	141	19	but	but	CC
cord-350992-l6l24pco	141	20	also	also	RB
cord-350992-l6l24pco	141	21	airway	airway	JJ
cord-350992-l6l24pco	141	22	epithelial	epithelial	JJ
cord-350992-l6l24pco	141	23	cells	cell	NNS
cord-350992-l6l24pco	141	24	have	have	VBP
cord-350992-l6l24pco	141	25	been	be	VBN
cord-350992-l6l24pco	141	26	demonstrated	demonstrate	VBN
cord-350992-l6l24pco	141	27	to	to	TO
cord-350992-l6l24pco	141	28	produce	produce	VB
cord-350992-l6l24pco	141	29	HAMP	HAMP	NNP
cord-350992-l6l24pco	141	30	during	during	IN
cord-350992-l6l24pco	141	31	infection	infection	NN
cord-350992-l6l24pco	141	32	and	and	CC
cord-350992-l6l24pco	141	33	inflammation	inflammation	NN
cord-350992-l6l24pco	141	34	and	and	CC
cord-350992-l6l24pco	141	35	potentially	potentially	RB
cord-350992-l6l24pco	141	36	contribute	contribute	VB
cord-350992-l6l24pco	141	37	to	to	IN
cord-350992-l6l24pco	141	38	lung	lung	NN
cord-350992-l6l24pco	141	39	injury	injury	NN
cord-350992-l6l24pco	141	40	[	[	-LRB-
cord-350992-l6l24pco	141	41	97	97	CD
cord-350992-l6l24pco	141	42	]	]	-RRB-
cord-350992-l6l24pco	141	43	[	[	-LRB-
cord-350992-l6l24pco	141	44	98	98	CD
cord-350992-l6l24pco	141	45	]	]	-RRB-
cord-350992-l6l24pco	141	46	[	[	-LRB-
cord-350992-l6l24pco	141	47	99	99	CD
cord-350992-l6l24pco	141	48	]	]	-RRB-
cord-350992-l6l24pco	141	49	.	.	.
cord-350992-l6l24pco	142	1	HAMP	HAMP	NNP
cord-350992-l6l24pco	142	2	is	be	VBZ
cord-350992-l6l24pco	142	3	also	also	RB
cord-350992-l6l24pco	142	4	a	a	DT
cord-350992-l6l24pco	142	5	peptide	peptide	NN
cord-350992-l6l24pco	142	6	involved	involve	VBN
cord-350992-l6l24pco	142	7	in	in	IN
cord-350992-l6l24pco	142	8	innate	innate	JJ
cord-350992-l6l24pco	142	9	antimicrobial	antimicrobial	JJ
cord-350992-l6l24pco	142	10	immunity	immunity	NN
cord-350992-l6l24pco	142	11	and	and	CC
cord-350992-l6l24pco	142	12	an	an	DT
cord-350992-l6l24pco	142	13	acute	acute	JJ
cord-350992-l6l24pco	142	14	phase	phase	NN
cord-350992-l6l24pco	142	15	protein	protein	NN
cord-350992-l6l24pco	142	16	[	[	-LRB-
cord-350992-l6l24pco	142	17	100	100	CD
cord-350992-l6l24pco	142	18	]	]	-RRB-
cord-350992-l6l24pco	142	19	.	.	.
cord-350992-l6l24pco	143	1	Further	further	JJ
cord-350992-l6l24pco	143	2	acute	acute	JJ
cord-350992-l6l24pco	143	3	phase	phase	NN
cord-350992-l6l24pco	143	4	iron	iron	NN
cord-350992-l6l24pco	143	5	-	-	HYPH
cord-350992-l6l24pco	143	6	related	relate	VBN
cord-350992-l6l24pco	143	7	proteins	protein	NNS
cord-350992-l6l24pco	143	8	like	like	IN
cord-350992-l6l24pco	143	9	transferrin	transferrin	NN
cord-350992-l6l24pco	143	10	(	(	-LRB-
cord-350992-l6l24pco	143	11	Tf	Tf	NNP
cord-350992-l6l24pco	143	12	)	)	-RRB-
cord-350992-l6l24pco	143	13	,	,	,
cord-350992-l6l24pco	143	14	lactoferrin	lactoferrin	NNP
cord-350992-l6l24pco	143	15	(	(	-LRB-
cord-350992-l6l24pco	143	16	LF	LF	NNP
cord-350992-l6l24pco	143	17	)	)	-RRB-
cord-350992-l6l24pco	143	18	,	,	,
cord-350992-l6l24pco	143	19	ferritin	ferritin	NN
cord-350992-l6l24pco	143	20	(	(	-LRB-
cord-350992-l6l24pco	143	21	FT	FT	NNP
cord-350992-l6l24pco	143	22	)	)	-RRB-
cord-350992-l6l24pco	143	23	,	,	,
cord-350992-l6l24pco	143	24	haptoglobin	haptoglobin	FW
cord-350992-l6l24pco	143	25	(	(	-LRB-
cord-350992-l6l24pco	143	26	HP	HP	NNP
cord-350992-l6l24pco	143	27	)	)	-RRB-
cord-350992-l6l24pco	143	28	and	and	CC
cord-350992-l6l24pco	143	29	hemopexin	hemopexin	NNP
cord-350992-l6l24pco	143	30	(	(	-LRB-
cord-350992-l6l24pco	143	31	HPX	HPX	NNP
cord-350992-l6l24pco	143	32	)	)	-RRB-
cord-350992-l6l24pco	143	33	are	be	VBP
cord-350992-l6l24pco	143	34	modulated	modulate	VBN
cord-350992-l6l24pco	143	35	by	by	IN
cord-350992-l6l24pco	143	36	viral	viral	JJ
cord-350992-l6l24pco	143	37	infections	infection	NNS
cord-350992-l6l24pco	143	38	,	,	,
cord-350992-l6l24pco	143	39	further	further	RB
cord-350992-l6l24pco	143	40	underlining	underline	VBG
cord-350992-l6l24pco	143	41	the	the	DT
cord-350992-l6l24pco	143	42	crucial	crucial	JJ
cord-350992-l6l24pco	143	43	role	role	NN
cord-350992-l6l24pco	143	44	of	of	IN
cord-350992-l6l24pco	143	45	iron	iron	NN
cord-350992-l6l24pco	143	46	in	in	IN
cord-350992-l6l24pco	143	47	anti	anti	JJ
cord-350992-l6l24pco	143	48	-	-	JJ
cord-350992-l6l24pco	143	49	viral	viral	JJ
cord-350992-l6l24pco	143	50	host	host	NN
cord-350992-l6l24pco	143	51	defense	defense	NN
cord-350992-l6l24pco	143	52	.	.	.
cord-350992-l6l24pco	144	1	The	the	DT
cord-350992-l6l24pco	144	2	role	role	NN
cord-350992-l6l24pco	144	3	of	of	IN
cord-350992-l6l24pco	144	4	iron	iron	NN
cord-350992-l6l24pco	144	5	metabolism	metabolism	NN
cord-350992-l6l24pco	144	6	has	have	VBZ
cord-350992-l6l24pco	144	7	been	be	VBN
cord-350992-l6l24pco	144	8	thoroughly	thoroughly	RB
cord-350992-l6l24pco	144	9	investigated	investigate	VBN
cord-350992-l6l24pco	144	10	in	in	IN
cord-350992-l6l24pco	144	11	several	several	JJ
cord-350992-l6l24pco	144	12	human	human	JJ
cord-350992-l6l24pco	144	13	viral	viral	JJ
cord-350992-l6l24pco	144	14	infections	infection	NNS
cord-350992-l6l24pco	144	15	.	.	.
cord-350992-l6l24pco	145	1	For	for	IN
cord-350992-l6l24pco	145	2	extensive	extensive	JJ
cord-350992-l6l24pco	145	3	reviews	review	NNS
cord-350992-l6l24pco	145	4	on	on	IN
cord-350992-l6l24pco	145	5	this	this	DT
cord-350992-l6l24pco	145	6	topic	topic	NN
cord-350992-l6l24pco	145	7	and	and	CC
cord-350992-l6l24pco	145	8	for	for	IN
cord-350992-l6l24pco	145	9	details	detail	NNS
cord-350992-l6l24pco	145	10	on	on	IN
cord-350992-l6l24pco	145	11	systemic	systemic	JJ
cord-350992-l6l24pco	145	12	and	and	CC
cord-350992-l6l24pco	145	13	cellular	cellular	JJ
cord-350992-l6l24pco	145	14	iron	iron	NN
cord-350992-l6l24pco	145	15	metabolism	metabolism	NN
cord-350992-l6l24pco	145	16	,	,	,
cord-350992-l6l24pco	145	17	please	please	UH
cord-350992-l6l24pco	145	18	refer	refer	VB
cord-350992-l6l24pco	145	19	to	to	IN
cord-350992-l6l24pco	145	20	[	[	-LRB-
cord-350992-l6l24pco	145	21	2	2	CD
cord-350992-l6l24pco	145	22	]	]	-RRB-
cord-350992-l6l24pco	145	23	[	[	-LRB-
cord-350992-l6l24pco	145	24	3	3	CD
cord-350992-l6l24pco	145	25	]	]	-RRB-
cord-350992-l6l24pco	145	26	[	[	-LRB-
cord-350992-l6l24pco	145	27	4	4	CD
cord-350992-l6l24pco	145	28	]	]	-RRB-
cord-350992-l6l24pco	145	29	101	101	CD
cord-350992-l6l24pco	145	30	]	]	-RRB-
cord-350992-l6l24pco	145	31	.	.	.
cord-350992-l6l24pco	146	1	CQ	CQ	NNP
cord-350992-l6l24pco	146	2	/	/	SYM
cord-350992-l6l24pco	146	3	HCQ	HCQ	NNP
cord-350992-l6l24pco	146	4	have	have	VBP
cord-350992-l6l24pco	146	5	been	be	VBN
cord-350992-l6l24pco	146	6	shown	show	VBN
cord-350992-l6l24pco	146	7	to	to	TO
cord-350992-l6l24pco	146	8	modulate	modulate	VB
cord-350992-l6l24pco	146	9	iron	iron	NN
cord-350992-l6l24pco	146	10	metabolism	metabolism	NN
cord-350992-l6l24pco	146	11	,	,	,
cord-350992-l6l24pco	146	12	impairing	impair	VBG
cord-350992-l6l24pco	146	13	its	-PRON-	PRP$
cord-350992-l6l24pco	146	14	homeostasis	homeostasis	NN
cord-350992-l6l24pco	146	15	at	at	IN
cord-350992-l6l24pco	146	16	different	different	JJ
cord-350992-l6l24pco	146	17	levels	level	NNS
cord-350992-l6l24pco	146	18	[	[	-LRB-
cord-350992-l6l24pco	146	19	43	43	CD
cord-350992-l6l24pco	146	20	,	,	,
cord-350992-l6l24pco	146	21	102	102	CD
cord-350992-l6l24pco	146	22	]	]	-RRB-
cord-350992-l6l24pco	146	23	,	,	,
cord-350992-l6l24pco	146	24	and	and	CC
cord-350992-l6l24pco	146	25	to	to	TO
cord-350992-l6l24pco	146	26	decrease	decrease	VB
cord-350992-l6l24pco	146	27	inflammatory	inflammatory	JJ
cord-350992-l6l24pco	146	28	cytokines	cytokine	NNS
cord-350992-l6l24pco	146	29	like	like	IN
cord-350992-l6l24pco	147	1	IL-6	IL-6	NNP
cord-350992-l6l24pco	147	2	,	,	,
cord-350992-l6l24pco	147	3	IL-1	IL-1	NNP
cord-350992-l6l24pco	147	4	and	and	CC
cord-350992-l6l24pco	148	1	TNF-.	TNF-.	NNP
cord-350992-l6l24pco	149	1	Here	here	RB
cord-350992-l6l24pco	149	2	we	-PRON-	PRP
cord-350992-l6l24pco	149	3	summarize	summarize	VBP
cord-350992-l6l24pco	149	4	the	the	DT
cord-350992-l6l24pco	149	5	more	more	RBR
cord-350992-l6l24pco	149	6	striking	striking	JJ
cord-350992-l6l24pco	149	7	evidences	evidence	NNS
cord-350992-l6l24pco	149	8	on	on	IN
cord-350992-l6l24pco	149	9	CQ	CQ	NNP
cord-350992-l6l24pco	149	10	/	/	SYM
cord-350992-l6l24pco	149	11	HCQ	HCQ	NNP
cord-350992-l6l24pco	149	12	action	action	NN
cord-350992-l6l24pco	149	13	on	on	IN
cord-350992-l6l24pco	149	14	cellular	cellular	JJ
cord-350992-l6l24pco	149	15	iron	iron	NN
cord-350992-l6l24pco	149	16	trafficking	trafficking	NN
cord-350992-l6l24pco	149	17	and	and	CC
cord-350992-l6l24pco	149	18	their	-PRON-	PRP$
cord-350992-l6l24pco	149	19	impact	impact	NN
cord-350992-l6l24pco	149	20	on	on	IN
cord-350992-l6l24pco	149	21	cellular	cellular	JJ
cord-350992-l6l24pco	149	22	and	and	CC
cord-350992-l6l24pco	149	23	systemic	systemic	JJ
cord-350992-l6l24pco	149	24	iron	iron	NN
cord-350992-l6l24pco	149	25	metabolism	metabolism	NN
cord-350992-l6l24pco	149	26	.	.	.
cord-350992-l6l24pco	150	1	We	-PRON-	PRP
cord-350992-l6l24pco	150	2	further	further	RB
cord-350992-l6l24pco	150	3	propose	propose	VBP
cord-350992-l6l24pco	150	4	alternative	alternative	JJ
cord-350992-l6l24pco	150	5	modes	mode	NNS
cord-350992-l6l24pco	150	6	of	of	IN
cord-350992-l6l24pco	150	7	action	action	NN
cord-350992-l6l24pco	150	8	for	for	IN
cord-350992-l6l24pco	150	9	these	these	DT
cord-350992-l6l24pco	150	10	drugs	drug	NNS
cord-350992-l6l24pco	150	11	,	,	,
cord-350992-l6l24pco	150	12	currently	currently	RB
cord-350992-l6l24pco	150	13	used	use	VBN
cord-350992-l6l24pco	150	14	in	in	IN
cord-350992-l6l24pco	150	15	the	the	DT
cord-350992-l6l24pco	150	16	treatment	treatment	NN
cord-350992-l6l24pco	150	17	of	of	IN
cord-350992-l6l24pco	150	18	COVID-19	COVID-19	NNP
cord-350992-l6l24pco	150	19	,	,	,
cord-350992-l6l24pco	150	20	that	that	WDT
cord-350992-l6l24pco	150	21	might	may	MD
cord-350992-l6l24pco	150	22	also	also	RB
cord-350992-l6l24pco	150	23	work	work	VB
cord-350992-l6l24pco	150	24	through	through	IN
cord-350992-l6l24pco	150	25	the	the	DT
cord-350992-l6l24pco	150	26	interference	interference	NN
cord-350992-l6l24pco	150	27	with	with	IN
cord-350992-l6l24pco	150	28	local	local	JJ
cord-350992-l6l24pco	150	29	and/or	and/or	CC
cord-350992-l6l24pco	150	30	systemic	systemic	JJ
cord-350992-l6l24pco	150	31	iron	iron	NN
cord-350992-l6l24pco	150	32	metabolism	metabolism	NN
cord-350992-l6l24pco	150	33	,	,	,
cord-350992-l6l24pco	150	34	restricting	restrict	VBG
cord-350992-l6l24pco	150	35	this	this	DT
cord-350992-l6l24pco	150	36	essential	essential	JJ
cord-350992-l6l24pco	150	37	element	element	NN
cord-350992-l6l24pco	150	38	in	in	IN
cord-350992-l6l24pco	150	39	infected	infected	JJ
cord-350992-l6l24pco	150	40	cells	cell	NNS
cord-350992-l6l24pco	150	41	and/or	and/or	CC
cord-350992-l6l24pco	150	42	immune	immune	JJ
cord-350992-l6l24pco	150	43	cells	cell	NNS
cord-350992-l6l24pco	150	44	involved	involve	VBN
cord-350992-l6l24pco	150	45	in	in	IN
cord-350992-l6l24pco	150	46	virus	virus	NN
cord-350992-l6l24pco	150	47	clearance	clearance	NN
cord-350992-l6l24pco	150	48	and/or	and/or	CC
cord-350992-l6l24pco	150	49	acting	act	VBG
cord-350992-l6l24pco	150	50	on	on	IN
cord-350992-l6l24pco	150	51	virus	virus	NN
cord-350992-l6l24pco	150	52	cell	cell	NN
cord-350992-l6l24pco	150	53	cycle	cycle	NN
cord-350992-l6l24pco	150	54	(	(	-LRB-
cord-350992-l6l24pco	150	55	Figure	figure	NN
cord-350992-l6l24pco	150	56	1	1	CD
cord-350992-l6l24pco	150	57	)	)	-RRB-
cord-350992-l6l24pco	150	58	.	.	.
cord-350992-l6l24pco	151	1	In	in	IN
cord-350992-l6l24pco	151	2	several	several	JJ
cord-350992-l6l24pco	151	3	experimental	experimental	JJ
cord-350992-l6l24pco	151	4	models	model	NNS
cord-350992-l6l24pco	151	5	,	,	,
cord-350992-l6l24pco	151	6	CQ	CQ	NNP
cord-350992-l6l24pco	151	7	has	have	VBZ
cord-350992-l6l24pco	151	8	been	be	VBN
cord-350992-l6l24pco	151	9	shown	show	VBN
cord-350992-l6l24pco	151	10	to	to	TO
cord-350992-l6l24pco	151	11	restrict	restrict	VB
cord-350992-l6l24pco	151	12	iron	iron	NN
cord-350992-l6l24pco	151	13	entry	entry	NN
cord-350992-l6l24pco	151	14	into	into	IN
cord-350992-l6l24pco	151	15	the	the	DT
cord-350992-l6l24pco	151	16	cells	cell	NNS
cord-350992-l6l24pco	151	17	.	.	.
cord-350992-l6l24pco	152	1	In	in	IN
cord-350992-l6l24pco	152	2	the	the	DT
cord-350992-l6l24pco	152	3	eukaryotic	eukaryotic	JJ
cord-350992-l6l24pco	152	4	model	model	NN
cord-350992-l6l24pco	152	5	Saccharomyces	Saccharomyces	NNP
cord-350992-l6l24pco	152	6	cerevisiae	cerevisiae	NNS
cord-350992-l6l24pco	152	7	,	,	,
cord-350992-l6l24pco	152	8	CQ	CQ	NNP
cord-350992-l6l24pco	152	9	interferes	interfere	VBZ
cord-350992-l6l24pco	152	10	with	with	IN
cord-350992-l6l24pco	152	11	iron	iron	NN
cord-350992-l6l24pco	152	12	uptake	uptake	NN
cord-350992-l6l24pco	152	13	,	,	,
cord-350992-l6l24pco	152	14	acting	act	VBG
cord-350992-l6l24pco	152	15	as	as	IN
cord-350992-l6l24pco	152	16	a	a	DT
cord-350992-l6l24pco	152	17	competitive	competitive	JJ
cord-350992-l6l24pco	152	18	inhibitor	inhibitor	NN
cord-350992-l6l24pco	152	19	of	of	IN
cord-350992-l6l24pco	152	20	iron	iron	NN
cord-350992-l6l24pco	152	21	entry	entry	NN
cord-350992-l6l24pco	152	22	and	and	CC
cord-350992-l6l24pco	152	23	inducing	induce	VBG
cord-350992-l6l24pco	152	24	iron	iron	NN
cord-350992-l6l24pco	152	25	starvation	starvation	NN
cord-350992-l6l24pco	152	26	.	.	.
cord-350992-l6l24pco	153	1	Iron	iron	NN
cord-350992-l6l24pco	153	2	-	-	HYPH
cord-350992-l6l24pco	153	3	deprived	deprive	VBN
cord-350992-l6l24pco	153	4	yeast	yeast	NN
cord-350992-l6l24pco	153	5	,	,	,
cord-350992-l6l24pco	153	6	by	by	IN
cord-350992-l6l24pco	153	7	means	mean	NNS
cord-350992-l6l24pco	153	8	of	of	IN
cord-350992-l6l24pco	153	9	knocking	knock	VBG
cord-350992-l6l24pco	153	10	-	-	HYPH
cord-350992-l6l24pco	153	11	out	out	RP
cord-350992-l6l24pco	153	12	genes	gene	NNS
cord-350992-l6l24pco	153	13	involved	involve	VBN
cord-350992-l6l24pco	153	14	in	in	IN
cord-350992-l6l24pco	153	15	iron	iron	NN
cord-350992-l6l24pco	153	16	uptake	uptake	NN
cord-350992-l6l24pco	153	17	or	or	CC
cord-350992-l6l24pco	153	18	by	by	IN
cord-350992-l6l24pco	153	19	using	use	VBG
cord-350992-l6l24pco	153	20	iron	iron	NN
cord-350992-l6l24pco	153	21	chelators	chelator	NNS
cord-350992-l6l24pco	153	22	,	,	,
cord-350992-l6l24pco	153	23	shows	show	VBZ
cord-350992-l6l24pco	153	24	increased	increase	VBN
cord-350992-l6l24pco	153	25	sensitivity	sensitivity	NN
cord-350992-l6l24pco	153	26	to	to	IN
cord-350992-l6l24pco	153	27	CQ	CQ	NNP
cord-350992-l6l24pco	153	28	[	[	-LRB-
cord-350992-l6l24pco	153	29	103	103	CD
cord-350992-l6l24pco	153	30	]	]	-RRB-
cord-350992-l6l24pco	153	31	.	.	.
cord-350992-l6l24pco	154	1	In	in	IN
cord-350992-l6l24pco	154	2	mammalian	mammalian	JJ
cord-350992-l6l24pco	154	3	cells	cell	NNS
cord-350992-l6l24pco	154	4	,	,	,
cord-350992-l6l24pco	154	5	CQ	CQ	NNP
cord-350992-l6l24pco	154	6	has	have	VBZ
cord-350992-l6l24pco	154	7	similar	similar	JJ
cord-350992-l6l24pco	154	8	effects	effect	NNS
cord-350992-l6l24pco	154	9	acting	act	VBG
cord-350992-l6l24pco	154	10	through	through	IN
cord-350992-l6l24pco	154	11	the	the	DT
cord-350992-l6l24pco	154	12	inhibition	inhibition	NN
cord-350992-l6l24pco	154	13	of	of	IN
cord-350992-l6l24pco	154	14	the	the	DT
cord-350992-l6l24pco	154	15	Tf	Tf	NNP
cord-350992-l6l24pco	154	16	/	/	SYM
cord-350992-l6l24pco	154	17	transferrin	transferrin	NN
cord-350992-l6l24pco	154	18	receptor	receptor	NN
cord-350992-l6l24pco	154	19	1	1	CD
cord-350992-l6l24pco	154	20	(	(	-LRB-
cord-350992-l6l24pco	154	21	TFR1	TFR1	NNP
cord-350992-l6l24pco	154	22	)	)	-RRB-
cord-350992-l6l24pco	154	23	complex	complex	JJ
cord-350992-l6l24pco	154	24	endocytosis	endocytosis	NN
cord-350992-l6l24pco	154	25	.	.	.
cord-350992-l6l24pco	155	1	The	the	DT
cord-350992-l6l24pco	155	2	first	first	JJ
cord-350992-l6l24pco	155	3	evidence	evidence	NN
cord-350992-l6l24pco	155	4	of	of	IN
cord-350992-l6l24pco	155	5	CQ	CQ	NNP
cord-350992-l6l24pco	155	6	inhibition	inhibition	NN
cord-350992-l6l24pco	155	7	of	of	IN
cord-350992-l6l24pco	155	8	Tf	Tf	NNP
cord-350992-l6l24pco	155	9	uptake	uptake	NN
cord-350992-l6l24pco	155	10	by	by	IN
cord-350992-l6l24pco	155	11	cells	cell	NNS
cord-350992-l6l24pco	155	12	was	be	VBD
cord-350992-l6l24pco	155	13	obtained	obtain	VBN
cord-350992-l6l24pco	155	14	in	in	IN
cord-350992-l6l24pco	155	15	cultured	cultured	JJ
cord-350992-l6l24pco	155	16	rat	rat	NN
cord-350992-l6l24pco	155	17	embryo	embryo	NN
cord-350992-l6l24pco	155	18	fibroblasts	fibroblast	NNS
cord-350992-l6l24pco	155	19	[	[	-LRB-
cord-350992-l6l24pco	155	20	104	104	CD
cord-350992-l6l24pco	155	21	]	]	-RRB-
cord-350992-l6l24pco	155	22	.	.	.
cord-350992-l6l24pco	156	1	Tf	Tf	NNP
cord-350992-l6l24pco	156	2	is	be	VBZ
cord-350992-l6l24pco	156	3	the	the	DT
cord-350992-l6l24pco	156	4	main	main	JJ
cord-350992-l6l24pco	156	5	plasma	plasma	NN
cord-350992-l6l24pco	156	6	iron	iron	NN
cord-350992-l6l24pco	156	7	carrier	carrier	NN
cord-350992-l6l24pco	156	8	which	which	WDT
cord-350992-l6l24pco	156	9	,	,	,
cord-350992-l6l24pco	156	10	maintaining	maintain	VBG
cord-350992-l6l24pco	156	11	this	this	DT
cord-350992-l6l24pco	156	12	cofactor	cofactor	NN
cord-350992-l6l24pco	156	13	in	in	IN
cord-350992-l6l24pco	156	14	a	a	DT
cord-350992-l6l24pco	156	15	redox	redox	JJ
cord-350992-l6l24pco	156	16	inert	inert	JJ
cord-350992-l6l24pco	156	17	state	state	NN
cord-350992-l6l24pco	156	18	,	,	,
cord-350992-l6l24pco	156	19	distributes	distribute	VBZ
cord-350992-l6l24pco	156	20	it	-PRON-	PRP
cord-350992-l6l24pco	156	21	to	to	IN
cord-350992-l6l24pco	156	22	most	most	JJS
cord-350992-l6l24pco	156	23	cells	cell	NNS
cord-350992-l6l24pco	156	24	of	of	IN
cord-350992-l6l24pco	156	25	the	the	DT
cord-350992-l6l24pco	156	26	human	human	JJ
cord-350992-l6l24pco	156	27	body	body	NN
cord-350992-l6l24pco	156	28	.	.	.
cord-350992-l6l24pco	157	1	Tf	Tf	NNP
cord-350992-l6l24pco	157	2	tightly	tightly	RB
cord-350992-l6l24pco	157	3	binds	bind	VBZ
cord-350992-l6l24pco	157	4	two	two	CD
cord-350992-l6l24pco	157	5	Fe	Fe	NNP
cord-350992-l6l24pco	157	6	3	3	CD
cord-350992-l6l24pco	157	7	+	+	CC
cord-350992-l6l24pco	157	8	.	.	.
cord-350992-l6l24pco	158	1	TFR1	TFR1	NNP
cord-350992-l6l24pco	158	2	,	,	,
cord-350992-l6l24pco	158	3	located	locate	VBN
cord-350992-l6l24pco	158	4	on	on	IN
cord-350992-l6l24pco	158	5	the	the	DT
cord-350992-l6l24pco	158	6	plasma	plasma	NN
cord-350992-l6l24pco	158	7	membrane	membrane	NN
cord-350992-l6l24pco	158	8	of	of	IN
cord-350992-l6l24pco	158	9	most	most	JJS
cord-350992-l6l24pco	158	10	types	type	NNS
cord-350992-l6l24pco	158	11	of	of	IN
cord-350992-l6l24pco	158	12	cell	cell	NN
cord-350992-l6l24pco	158	13	,	,	,
cord-350992-l6l24pco	158	14	binds	bind	VBZ
cord-350992-l6l24pco	158	15	and	and	CC
cord-350992-l6l24pco	158	16	internalizes	internalize	VBZ
cord-350992-l6l24pco	158	17	Tf	Tf	NNP
cord-350992-l6l24pco	158	18	into	into	IN
cord-350992-l6l24pco	158	19	endocytic	endocytic	JJ
cord-350992-l6l24pco	158	20	vesicles	vesicle	NNS
cord-350992-l6l24pco	158	21	through	through	IN
cord-350992-l6l24pco	158	22	CME	CME	NNP
cord-350992-l6l24pco	158	23	[	[	-LRB-
cord-350992-l6l24pco	158	24	105	105	CD
cord-350992-l6l24pco	158	25	]	]	-RRB-
cord-350992-l6l24pco	158	26	.	.	.
cord-350992-l6l24pco	159	1	As	as	IN
cord-350992-l6l24pco	159	2	stated	state	VBN
cord-350992-l6l24pco	159	3	above	above	RB
cord-350992-l6l24pco	159	4	,	,	,
cord-350992-l6l24pco	159	5	CQ	CQ	NNP
cord-350992-l6l24pco	159	6	has	have	VBZ
cord-350992-l6l24pco	159	7	been	be	VBN
cord-350992-l6l24pco	159	8	demonstrated	demonstrate	VBN
cord-350992-l6l24pco	159	9	to	to	TO
cord-350992-l6l24pco	159	10	reduce	reduce	VB
cord-350992-l6l24pco	159	11	PICALM	PICALM	NNP
cord-350992-l6l24pco	159	12	expression	expression	NN
cord-350992-l6l24pco	159	13	in	in	IN
cord-350992-l6l24pco	159	14	macrophages	macrophage	NNS
cord-350992-l6l24pco	159	15	of	of	IN
cord-350992-l6l24pco	159	16	treated	treat	VBN
cord-350992-l6l24pco	159	17	mice	mouse	NNS
cord-350992-l6l24pco	159	18	[	[	-LRB-
cord-350992-l6l24pco	159	19	15	15	CD
cord-350992-l6l24pco	159	20	]	]	-RRB-
cord-350992-l6l24pco	159	21	.	.	.
cord-350992-l6l24pco	160	1	This	this	DT
cord-350992-l6l24pco	160	2	ubiquitously	ubiquitously	RB
cord-350992-l6l24pco	160	3	expressed	express	VBD
cord-350992-l6l24pco	160	4	protein	protein	NN
cord-350992-l6l24pco	160	5	is	be	VBZ
cord-350992-l6l24pco	160	6	involved	involve	VBN
cord-350992-l6l24pco	160	7	in	in	IN
cord-350992-l6l24pco	160	8	CME	CME	NNP
cord-350992-l6l24pco	160	9	and	and	CC
cord-350992-l6l24pco	160	10	its	-PRON-	PRP$
cord-350992-l6l24pco	160	11	deficiency	deficiency	NN
cord-350992-l6l24pco	160	12	has	have	VBZ
cord-350992-l6l24pco	160	13	been	be	VBN
cord-350992-l6l24pco	160	14	demonstrated	demonstrate	VBN
cord-350992-l6l24pco	160	15	to	to	TO
cord-350992-l6l24pco	160	16	result	result	VB
cord-350992-l6l24pco	160	17	in	in	IN
cord-350992-l6l24pco	160	18	anemia	anemia	NN
cord-350992-l6l24pco	160	19	and	and	CC
cord-350992-l6l24pco	160	20	abnormal	abnormal	JJ
cord-350992-l6l24pco	160	21	iron	iron	NN
cord-350992-l6l24pco	160	22	metabolism	metabolism	NN
cord-350992-l6l24pco	160	23	in	in	IN
cord-350992-l6l24pco	160	24	mice	mouse	NNS
cord-350992-l6l24pco	160	25	[	[	-LRB-
cord-350992-l6l24pco	160	26	106	106	CD
cord-350992-l6l24pco	160	27	,	,	,
cord-350992-l6l24pco	160	28	107	107	CD
cord-350992-l6l24pco	160	29	]	]	-RRB-
cord-350992-l6l24pco	160	30	and	and	CC
cord-350992-l6l24pco	160	31	iron	iron	NN
cord-350992-l6l24pco	160	32	starvation	starvation	NN
cord-350992-l6l24pco	160	33	,	,	,
cord-350992-l6l24pco	160	34	with	with	IN
cord-350992-l6l24pco	160	35	increased	increase	VBN
cord-350992-l6l24pco	160	36	surface	surface	NN
cord-350992-l6l24pco	160	37	TFR1	TFR1	NNP
cord-350992-l6l24pco	160	38	expression	expression	NN
cord-350992-l6l24pco	160	39	and	and	CC
cord-350992-l6l24pco	160	40	decreased	decrease	VBD
cord-350992-l6l24pco	160	41	intracellular	intracellular	JJ
cord-350992-l6l24pco	160	42	iron	iron	NN
cord-350992-l6l24pco	160	43	levels	level	NNS
cord-350992-l6l24pco	160	44	,	,	,
cord-350992-l6l24pco	160	45	in	in	IN
cord-350992-l6l24pco	160	46	murine	murine	JJ
cord-350992-l6l24pco	160	47	embryonic	embryonic	JJ
cord-350992-l6l24pco	160	48	fibroblasts	fibroblast	NNS
cord-350992-l6l24pco	160	49	[	[	-LRB-
cord-350992-l6l24pco	160	50	108	108	CD
cord-350992-l6l24pco	160	51	]	]	-RRB-
cord-350992-l6l24pco	160	52	.	.	.
cord-350992-l6l24pco	161	1	Then	then	RB
cord-350992-l6l24pco	161	2	,	,	,
cord-350992-l6l24pco	161	3	CQ	CQ	NNP
cord-350992-l6l24pco	161	4	/	/	SYM
cord-350992-l6l24pco	161	5	HCQ	HCQ	NNP
cord-350992-l6l24pco	161	6	treatment	treatment	NN
cord-350992-l6l24pco	161	7	may	may	MD
cord-350992-l6l24pco	161	8	result	result	VB
cord-350992-l6l24pco	161	9	in	in	IN
cord-350992-l6l24pco	161	10	the	the	DT
cord-350992-l6l24pco	161	11	inhibition	inhibition	NN
cord-350992-l6l24pco	161	12	of	of	IN
cord-350992-l6l24pco	161	13	Tf	Tf	NNP
cord-350992-l6l24pco	161	14	/	/	SYM
cord-350992-l6l24pco	161	15	TFR1	TFR1	NNP
cord-350992-l6l24pco	161	16	complex	complex	JJ
cord-350992-l6l24pco	161	17	uptake	uptake	NN
cord-350992-l6l24pco	161	18	and	and	CC
cord-350992-l6l24pco	161	19	cellular	cellular	JJ
cord-350992-l6l24pco	161	20	iron	iron	NN
cord-350992-l6l24pco	161	21	starvation	starvation	NN
cord-350992-l6l24pco	161	22	.	.	.
cord-350992-l6l24pco	162	1	The	the	DT
cord-350992-l6l24pco	162	2	release	release	NN
cord-350992-l6l24pco	162	3	of	of	IN
cord-350992-l6l24pco	162	4	iron	iron	NN
cord-350992-l6l24pco	162	5	from	from	IN
cord-350992-l6l24pco	162	6	Tf	Tf	NNP
cord-350992-l6l24pco	162	7	after	after	IN
cord-350992-l6l24pco	162	8	iron	iron	NN
cord-350992-l6l24pco	162	9	-	-	HYPH
cord-350992-l6l24pco	162	10	loaded	load	VBN
cord-350992-l6l24pco	162	11	Tf	Tf	NNP
cord-350992-l6l24pco	162	12	/	/	SYM
cord-350992-l6l24pco	162	13	TFR1	TFR1	NNP
cord-350992-l6l24pco	162	14	complex	complex	NN
cord-350992-l6l24pco	162	15	CME	CME	NNP
cord-350992-l6l24pco	162	16	and	and	CC
cord-350992-l6l24pco	162	17	its	-PRON-	PRP$
cord-350992-l6l24pco	162	18	translocation	translocation	NN
cord-350992-l6l24pco	162	19	into	into	IN
cord-350992-l6l24pco	162	20	the	the	DT
cord-350992-l6l24pco	162	21	cytosol	cytosol	NN
cord-350992-l6l24pco	162	22	is	be	VBZ
cord-350992-l6l24pco	162	23	a	a	DT
cord-350992-l6l24pco	162	24	fundamental	fundamental	JJ
cord-350992-l6l24pco	162	25	step	step	NN
cord-350992-l6l24pco	162	26	for	for	IN
cord-350992-l6l24pco	162	27	iron	iron	NN
cord-350992-l6l24pco	162	28	cellular	cellular	JJ
cord-350992-l6l24pco	162	29	acquisition	acquisition	NN
cord-350992-l6l24pco	162	30	and	and	CC
cord-350992-l6l24pco	162	31	further	further	JJ
cord-350992-l6l24pco	162	32	usage	usage	NN
cord-350992-l6l24pco	162	33	.	.	.
cord-350992-l6l24pco	163	1	The	the	DT
cord-350992-l6l24pco	163	2	acidic	acidic	JJ
cord-350992-l6l24pco	163	3	milieau	milieau	NN
cord-350992-l6l24pco	163	4	of	of	IN
cord-350992-l6l24pco	163	5	endosomes	endosome	NNS
cord-350992-l6l24pco	163	6	weakens	weaken	VBZ
cord-350992-l6l24pco	163	7	the	the	DT
cord-350992-l6l24pco	163	8	binding	binding	NN
cord-350992-l6l24pco	163	9	of	of	IN
cord-350992-l6l24pco	163	10	Tf	Tf	NNP
cord-350992-l6l24pco	163	11	to	to	IN
cord-350992-l6l24pco	163	12	Fe	Fe	NNP
cord-350992-l6l24pco	163	13	3	3	CD
cord-350992-l6l24pco	163	14	+	+	CC
cord-350992-l6l24pco	163	15	,	,	,
cord-350992-l6l24pco	163	16	enabling	enable	VBG
cord-350992-l6l24pco	163	17	its	-PRON-	PRP$
cord-350992-l6l24pco	163	18	release	release	NN
cord-350992-l6l24pco	163	19	within	within	IN
cord-350992-l6l24pco	163	20	these	these	DT
cord-350992-l6l24pco	163	21	vesicles	vesicle	NNS
cord-350992-l6l24pco	163	22	[	[	-LRB-
cord-350992-l6l24pco	163	23	105	105	CD
cord-350992-l6l24pco	163	24	]	]	-RRB-
cord-350992-l6l24pco	163	25	.	.	.
cord-350992-l6l24pco	164	1	CQ	CQ	NNP
cord-350992-l6l24pco	164	2	/	/	SYM
cord-350992-l6l24pco	164	3	HCQ	HCQ	NNP
cord-350992-l6l24pco	164	4	,	,	,
cord-350992-l6l24pco	164	5	by	by	IN
cord-350992-l6l24pco	164	6	virtue	virtue	NN
cord-350992-l6l24pco	164	7	of	of	IN
cord-350992-l6l24pco	164	8	their	-PRON-	PRP$
cord-350992-l6l24pco	164	9	basic	basic	JJ
cord-350992-l6l24pco	164	10	properties	property	NNS
cord-350992-l6l24pco	164	11	,	,	,
cord-350992-l6l24pco	164	12	raise	raise	VB
cord-350992-l6l24pco	164	13	pH	ph	NN
cord-350992-l6l24pco	164	14	of	of	IN
cord-350992-l6l24pco	164	15	endocytic	endocytic	JJ
cord-350992-l6l24pco	164	16	vesicles	vesicle	NNS
cord-350992-l6l24pco	164	17	,	,	,
cord-350992-l6l24pco	164	18	possibly	possibly	RB
cord-350992-l6l24pco	164	19	inhibiting	inhibit	VBG
cord-350992-l6l24pco	164	20	iron	iron	NN
cord-350992-l6l24pco	164	21	removal	removal	NN
cord-350992-l6l24pco	164	22	from	from	IN
cord-350992-l6l24pco	164	23	Tf	Tf	NNP
cord-350992-l6l24pco	164	24	within	within	IN
cord-350992-l6l24pco	164	25	endocytic	endocytic	JJ
cord-350992-l6l24pco	164	26	vesicles	vesicle	NNS
cord-350992-l6l24pco	164	27	.	.	.
cord-350992-l6l24pco	165	1	Within	within	IN
cord-350992-l6l24pco	165	2	endocytic	endocytic	JJ
cord-350992-l6l24pco	165	3	vesicles	vesicle	NNS
cord-350992-l6l24pco	165	4	,	,	,
cord-350992-l6l24pco	165	5	released	release	VBN
cord-350992-l6l24pco	165	6	Fe	Fe	NNP
cord-350992-l6l24pco	165	7	3	3	CD
cord-350992-l6l24pco	165	8	+	+	CC
cord-350992-l6l24pco	165	9	is	be	VBZ
cord-350992-l6l24pco	165	10	reduced	reduce	VBN
cord-350992-l6l24pco	165	11	to	to	IN
cord-350992-l6l24pco	165	12	Fe	Fe	NNP
cord-350992-l6l24pco	165	13	2	2	CD
cord-350992-l6l24pco	165	14	+	+	SYM
cord-350992-l6l24pco	165	15	by	by	IN
cord-350992-l6l24pco	165	16	the	the	DT
cord-350992-l6l24pco	165	17	metalloreductase	metalloreductase	NNP
cord-350992-l6l24pco	165	18	six	six	CD
cord-350992-l6l24pco	165	19	-	-	HYPH
cord-350992-l6l24pco	165	20	transmembrane	transmembrane	NN
cord-350992-l6l24pco	165	21	epithelial	epithelial	JJ
cord-350992-l6l24pco	165	22	antigen	antigen	NN
cord-350992-l6l24pco	165	23	of	of	IN
cord-350992-l6l24pco	165	24	the	the	DT
cord-350992-l6l24pco	165	25	prostate	prostate	NN
cord-350992-l6l24pco	165	26	3	3	CD
cord-350992-l6l24pco	165	27	(	(	-LRB-
cord-350992-l6l24pco	165	28	STEAP3	STEAP3	VBZ
cord-350992-l6l24pco	165	29	)	)	-RRB-
cord-350992-l6l24pco	165	30	and	and	CC
cord-350992-l6l24pco	165	31	exported	export	VBN
cord-350992-l6l24pco	165	32	from	from	IN
cord-350992-l6l24pco	165	33	the	the	DT
cord-350992-l6l24pco	165	34	lysosomes	lysosome	NNS
cord-350992-l6l24pco	165	35	to	to	IN
cord-350992-l6l24pco	165	36	the	the	DT
cord-350992-l6l24pco	165	37	cytosol	cytosol	NN
cord-350992-l6l24pco	165	38	through	through	IN
cord-350992-l6l24pco	165	39	the	the	DT
cord-350992-l6l24pco	165	40	divalent	divalent	JJ
cord-350992-l6l24pco	165	41	metal	metal	NN
cord-350992-l6l24pco	165	42	-	-	HYPH
cord-350992-l6l24pco	165	43	ion	ion	NN
cord-350992-l6l24pco	165	44	transporter	transporter	NN
cord-350992-l6l24pco	165	45	1	1	CD
cord-350992-l6l24pco	165	46	(	(	-LRB-
cord-350992-l6l24pco	165	47	DMT1	DMT1	NNP
cord-350992-l6l24pco	165	48	)	)	-RRB-
cord-350992-l6l24pco	165	49	,	,	,
cord-350992-l6l24pco	165	50	mucolipin	mucolipin	NNP
cord-350992-l6l24pco	165	51	1	1	CD
cord-350992-l6l24pco	165	52	(	(	-LRB-
cord-350992-l6l24pco	165	53	TRPML1	TRPML1	NNP
cord-350992-l6l24pco	165	54	/	/	SYM
cord-350992-l6l24pco	165	55	MCOLN1	MCOLN1	NNP
cord-350992-l6l24pco	165	56	)	)	-RRB-
cord-350992-l6l24pco	165	57	and	and	CC
cord-350992-l6l24pco	165	58	other	other	JJ
cord-350992-l6l24pco	165	59	transporters	transporter	NNS
cord-350992-l6l24pco	165	60	[	[	-LRB-
cord-350992-l6l24pco	165	61	105	105	CD
cord-350992-l6l24pco	165	62	]	]	-RRB-
cord-350992-l6l24pco	165	63	.	.	.
cord-350992-l6l24pco	166	1	Iron	iron	NN
cord-350992-l6l24pco	166	2	transport	transport	NN
cord-350992-l6l24pco	166	3	through	through	IN
cord-350992-l6l24pco	166	4	DMT1	DMT1	NNP
cord-350992-l6l24pco	166	5	is	be	VBZ
cord-350992-l6l24pco	166	6	pH	pH	NNP
cord-350992-l6l24pco	166	7	dependent	dependent	JJ
cord-350992-l6l24pco	166	8	,	,	,
cord-350992-l6l24pco	166	9	being	be	VBG
cord-350992-l6l24pco	166	10	stimulated	stimulate	VBN
cord-350992-l6l24pco	166	11	at	at	IN
cord-350992-l6l24pco	166	12	low	low	JJ
cord-350992-l6l24pco	166	13	pH.	ph.	NN
cord-350992-l6l24pco	166	14	DMT1	DMT1	NNP
cord-350992-l6l24pco	166	15	is	be	VBZ
cord-350992-l6l24pco	166	16	indeed	indeed	RB
cord-350992-l6l24pco	166	17	a	a	DT
cord-350992-l6l24pco	166	18	H	h	NN
cord-350992-l6l24pco	167	1	+	+	CC
cord-350992-l6l24pco	167	2	/Fe	/Fe	.
cord-350992-l6l24pco	168	1	2	2	LS
cord-350992-l6l24pco	168	2	+	+	CC
cord-350992-l6l24pco	168	3	symporter	symporter	NN
cord-350992-l6l24pco	168	4	that	that	WDT
cord-350992-l6l24pco	168	5	needs	need	VBZ
cord-350992-l6l24pco	168	6	a	a	DT
cord-350992-l6l24pco	168	7	proton	proton	NN
cord-350992-l6l24pco	168	8	electrochemical	electrochemical	JJ
cord-350992-l6l24pco	168	9	potential	potential	JJ
cord-350992-l6l24pco	168	10	gradient	gradient	NN
cord-350992-l6l24pco	168	11	as	as	IN
cord-350992-l6l24pco	168	12	driving	drive	VBG
cord-350992-l6l24pco	168	13	force	force	NN
cord-350992-l6l24pco	168	14	to	to	TO
cord-350992-l6l24pco	168	15	transport	transport	VB
cord-350992-l6l24pco	168	16	iron	iron	NN
cord-350992-l6l24pco	168	17	from	from	IN
cord-350992-l6l24pco	168	18	endosomes	endosome	NNS
cord-350992-l6l24pco	168	19	into	into	IN
cord-350992-l6l24pco	168	20	the	the	DT
cord-350992-l6l24pco	168	21	cytoplasm	cytoplasm	NN
cord-350992-l6l24pco	168	22	[	[	-LRB-
cord-350992-l6l24pco	168	23	109	109	CD
cord-350992-l6l24pco	168	24	]	]	-RRB-
cord-350992-l6l24pco	168	25	.	.	.
cord-350992-l6l24pco	169	1	TRPML1	TRPML1	NNP
cord-350992-l6l24pco	169	2	/	/	SYM
cord-350992-l6l24pco	169	3	MCOLN1	MCOLN1	NNP
cord-350992-l6l24pco	169	4	is	be	VBZ
cord-350992-l6l24pco	169	5	a	a	DT
cord-350992-l6l24pco	169	6	non	non	JJ
cord-350992-l6l24pco	169	7	-	-	JJ
cord-350992-l6l24pco	169	8	selective	selective	JJ
cord-350992-l6l24pco	169	9	channel	channel	NN
cord-350992-l6l24pco	169	10	permeable	permeable	JJ
cord-350992-l6l24pco	169	11	to	to	IN
cord-350992-l6l24pco	169	12	various	various	JJ
cord-350992-l6l24pco	169	13	cations	cation	NNS
cord-350992-l6l24pco	169	14	such	such	JJ
cord-350992-l6l24pco	169	15	as	as	IN
cord-350992-l6l24pco	169	16	Ca	Ca	NNP
cord-350992-l6l24pco	169	17	2	2	CD
cord-350992-l6l24pco	169	18	+	+	SYM
cord-350992-l6l24pco	169	19	,	,	,
cord-350992-l6l24pco	169	20	Na	Na	NNP
cord-350992-l6l24pco	169	21	+	+	CC
cord-350992-l6l24pco	170	1	and	and	CC
cord-350992-l6l24pco	170	2	K	K	NNP
cord-350992-l6l24pco	171	1	+	+	CC
cord-350992-l6l24pco	171	2	that	that	DT
cord-350992-l6l24pco	171	3	can	can	MD
cord-350992-l6l24pco	171	4	also	also	RB
cord-350992-l6l24pco	171	5	transport	transport	VB
cord-350992-l6l24pco	171	6	Fe	Fe	NNP
cord-350992-l6l24pco	171	7	2	2	CD
cord-350992-l6l24pco	172	1	+	+	UH
cord-350992-l6l24pco	172	2	.	.	.
cord-350992-l6l24pco	173	1	It	-PRON-	PRP
cord-350992-l6l24pco	173	2	mainly	mainly	RB
cord-350992-l6l24pco	173	3	localizes	localize	VBZ
cord-350992-l6l24pco	173	4	in	in	IN
cord-350992-l6l24pco	173	5	late	late	JJ
cord-350992-l6l24pco	173	6	endosomes	endosome	NNS
cord-350992-l6l24pco	173	7	and	and	CC
cord-350992-l6l24pco	173	8	lysosomes	lysosome	NNS
cord-350992-l6l24pco	173	9	and	and	CC
cord-350992-l6l24pco	173	10	the	the	DT
cord-350992-l6l24pco	173	11	acidic	acidic	JJ
cord-350992-l6l24pco	173	12	environment	environment	NN
cord-350992-l6l24pco	173	13	of	of	IN
cord-350992-l6l24pco	173	14	these	these	DT
cord-350992-l6l24pco	173	15	vesicles	vesicle	NNS
cord-350992-l6l24pco	173	16	activates	activate	VBZ
cord-350992-l6l24pco	173	17	this	this	DT
cord-350992-l6l24pco	173	18	channel	channel	NN
cord-350992-l6l24pco	173	19	and	and	CC
cord-350992-l6l24pco	173	20	the	the	DT
cord-350992-l6l24pco	173	21	release	release	NN
cord-350992-l6l24pco	173	22	of	of	IN
cord-350992-l6l24pco	173	23	cations	cation	NNS
cord-350992-l6l24pco	173	24	from	from	IN
cord-350992-l6l24pco	173	25	the	the	DT
cord-350992-l6l24pco	173	26	lumen	lumen	NN
cord-350992-l6l24pco	173	27	into	into	IN
cord-350992-l6l24pco	173	28	the	the	DT
cord-350992-l6l24pco	173	29	cytosol	cytosol	NN
cord-350992-l6l24pco	173	30	[	[	-LRB-
cord-350992-l6l24pco	173	31	110	110	CD
cord-350992-l6l24pco	173	32	]	]	-RRB-
cord-350992-l6l24pco	173	33	.	.	.
cord-350992-l6l24pco	174	1	Then	then	RB
cord-350992-l6l24pco	174	2	CQ	CQ	NNP
cord-350992-l6l24pco	174	3	/	/	SYM
cord-350992-l6l24pco	174	4	HCQ	HCQ	NNP
cord-350992-l6l24pco	174	5	could	could	MD
cord-350992-l6l24pco	174	6	also	also	RB
cord-350992-l6l24pco	174	7	inhibit	inhibit	VB
cord-350992-l6l24pco	174	8	iron	iron	NN
cord-350992-l6l24pco	174	9	release	release	NN
cord-350992-l6l24pco	174	10	from	from	IN
cord-350992-l6l24pco	174	11	endosomes	endosome	NNS
cord-350992-l6l24pco	174	12	into	into	IN
cord-350992-l6l24pco	174	13	the	the	DT
cord-350992-l6l24pco	174	14	cytosol	cytosol	NN
cord-350992-l6l24pco	174	15	.	.	.
cord-350992-l6l24pco	175	1	The	the	DT
cord-350992-l6l24pco	175	2	alkalizing	alkalize	VBG
cord-350992-l6l24pco	175	3	properties	property	NNS
cord-350992-l6l24pco	175	4	of	of	IN
cord-350992-l6l24pco	175	5	CQ	CQ	NNP
cord-350992-l6l24pco	175	6	/	/	SYM
cord-350992-l6l24pco	175	7	HCQ	HCQ	NNP
cord-350992-l6l24pco	175	8	have	have	VBP
cord-350992-l6l24pco	175	9	been	be	VBN
cord-350992-l6l24pco	175	10	widely	widely	RB
cord-350992-l6l24pco	175	11	used	use	VBN
cord-350992-l6l24pco	175	12	to	to	TO
cord-350992-l6l24pco	175	13	impair	impair	VB
cord-350992-l6l24pco	175	14	the	the	DT
cord-350992-l6l24pco	175	15	endosome	endosome	NN
cord-350992-l6l24pco	175	16	/	/	SYM
cord-350992-l6l24pco	175	17	lysosome	lysosome	NN
cord-350992-l6l24pco	175	18	fusion	fusion	NN
cord-350992-l6l24pco	175	19	and	and	CC
cord-350992-l6l24pco	175	20	inhibit	inhibit	VB
cord-350992-l6l24pco	175	21	autophagic	autophagic	NN
cord-350992-l6l24pco	175	22	flux	flux	NN
cord-350992-l6l24pco	175	23	[	[	-LRB-
cord-350992-l6l24pco	175	24	5	5	CD
cord-350992-l6l24pco	175	25	]	]	-RRB-
cord-350992-l6l24pco	175	26	.	.	.
cord-350992-l6l24pco	176	1	FT	FT	NNP
cord-350992-l6l24pco	176	2	is	be	VBZ
cord-350992-l6l24pco	176	3	the	the	DT
cord-350992-l6l24pco	176	4	main	main	JJ
cord-350992-l6l24pco	176	5	iron	iron	NN
cord-350992-l6l24pco	176	6	storage	storage	NN
cord-350992-l6l24pco	176	7	cellular	cellular	JJ
cord-350992-l6l24pco	176	8	protein	protein	NN
cord-350992-l6l24pco	176	9	that	that	WDT
cord-350992-l6l24pco	176	10	compartmentalizes	compartmentalize	VBZ
cord-350992-l6l24pco	176	11	iron	iron	NN
cord-350992-l6l24pco	176	12	in	in	IN
cord-350992-l6l24pco	176	13	a	a	DT
cord-350992-l6l24pco	176	14	nonreactive	nonreactive	JJ
cord-350992-l6l24pco	176	15	form	form	NN
cord-350992-l6l24pco	176	16	within	within	IN
cord-350992-l6l24pco	176	17	the	the	DT
cord-350992-l6l24pco	176	18	cell	cell	NN
cord-350992-l6l24pco	176	19	,	,	,
cord-350992-l6l24pco	176	20	until	until	IN
cord-350992-l6l24pco	176	21	use	use	NN
cord-350992-l6l24pco	176	22	.	.	.
cord-350992-l6l24pco	177	1	Iron	iron	NN
cord-350992-l6l24pco	177	2	release	release	NN
cord-350992-l6l24pco	177	3	from	from	IN
cord-350992-l6l24pco	177	4	FT	FT	NNP
cord-350992-l6l24pco	177	5	mainly	mainly	RB
cord-350992-l6l24pco	177	6	occurs	occur	VBZ
cord-350992-l6l24pco	177	7	through	through	IN
cord-350992-l6l24pco	177	8	protein	protein	NN
cord-350992-l6l24pco	177	9	degradation	degradation	NN
cord-350992-l6l24pco	177	10	by	by	IN
cord-350992-l6l24pco	177	11	a	a	DT
cord-350992-l6l24pco	177	12	selective	selective	JJ
cord-350992-l6l24pco	177	13	lysosome	lysosome	NN
cord-350992-l6l24pco	177	14	-	-	HYPH
cord-350992-l6l24pco	177	15	autophagy	autophagy	NN
cord-350992-l6l24pco	177	16	pathway	pathway	NN
cord-350992-l6l24pco	177	17	named	name	VBN
cord-350992-l6l24pco	177	18	ferritinophagy	ferritinophagy	NNP
cord-350992-l6l24pco	177	19	[	[	-LRB-
cord-350992-l6l24pco	177	20	101	101	CD
cord-350992-l6l24pco	177	21	,	,	,
cord-350992-l6l24pco	177	22	111	111	CD
cord-350992-l6l24pco	177	23	]	]	-RRB-
cord-350992-l6l24pco	177	24	that	that	WDT
cord-350992-l6l24pco	177	25	is	be	VBZ
cord-350992-l6l24pco	177	26	inhibited	inhibit	VBN
cord-350992-l6l24pco	177	27	by	by	IN
cord-350992-l6l24pco	177	28	CQ	CQ	NNP
cord-350992-l6l24pco	177	29	[	[	-LRB-
cord-350992-l6l24pco	177	30	112	112	CD
cord-350992-l6l24pco	177	31	]	]	-RRB-
cord-350992-l6l24pco	177	32	.	.	.
cord-350992-l6l24pco	178	1	Further	further	RB
cord-350992-l6l24pco	178	2	,	,	,
cord-350992-l6l24pco	178	3	DMT1	DMT1	NNP
cord-350992-l6l24pco	178	4	and	and	CC
cord-350992-l6l24pco	178	5	TRPML1	TRPML1	NNP
cord-350992-l6l24pco	178	6	have	have	VBP
cord-350992-l6l24pco	178	7	been	be	VBN
cord-350992-l6l24pco	178	8	implicated	implicate	VBN
cord-350992-l6l24pco	178	9	in	in	IN
cord-350992-l6l24pco	178	10	the	the	DT
cord-350992-l6l24pco	178	11	release	release	NN
cord-350992-l6l24pco	178	12	of	of	IN
cord-350992-l6l24pco	178	13	iron	iron	NN
cord-350992-l6l24pco	178	14	derived	derive	VBN
cord-350992-l6l24pco	178	15	from	from	IN
cord-350992-l6l24pco	178	16	ferritinophagy	ferritinophagy	NN
cord-350992-l6l24pco	178	17	and	and	CC
cord-350992-l6l24pco	178	18	entrapped	entrap	VBN
cord-350992-l6l24pco	178	19	in	in	IN
cord-350992-l6l24pco	178	20	autophagic	autophagic	JJ
cord-350992-l6l24pco	178	21	vesicles	vesicle	NNS
cord-350992-l6l24pco	178	22	and	and	CC
cord-350992-l6l24pco	178	23	,	,	,
cord-350992-l6l24pco	178	24	as	as	IN
cord-350992-l6l24pco	178	25	stated	state	VBN
cord-350992-l6l24pco	178	26	above	above	RB
cord-350992-l6l24pco	178	27	,	,	,
cord-350992-l6l24pco	178	28	both	both	DT
cord-350992-l6l24pco	178	29	require	require	VBP
cord-350992-l6l24pco	178	30	an	an	DT
cord-350992-l6l24pco	178	31	acidic	acidic	JJ
cord-350992-l6l24pco	178	32	environment	environment	NN
cord-350992-l6l24pco	178	33	for	for	IN
cord-350992-l6l24pco	178	34	their	-PRON-	PRP$
cord-350992-l6l24pco	178	35	channel	channel	NN
cord-350992-l6l24pco	178	36	functions	function	NNS
cord-350992-l6l24pco	178	37	.	.	.
cord-350992-l6l24pco	179	1	All	all	PDT
cord-350992-l6l24pco	179	2	the	the	DT
cord-350992-l6l24pco	179	3	steps	step	NNS
cord-350992-l6l24pco	179	4	described	describe	VBN
cord-350992-l6l24pco	179	5	above	above	IN
cord-350992-l6l24pco	179	6	result	result	NN
cord-350992-l6l24pco	179	7	in	in	IN
cord-350992-l6l24pco	179	8	cellular	cellular	JJ
cord-350992-l6l24pco	179	9	iron	iron	NN
cord-350992-l6l24pco	179	10	starvation	starvation	NN
cord-350992-l6l24pco	179	11	.	.	.
cord-350992-l6l24pco	180	1	This	this	DT
cord-350992-l6l24pco	180	2	condition	condition	NN
cord-350992-l6l24pco	180	3	might	may	MD
cord-350992-l6l24pco	180	4	possibly	possibly	RB
cord-350992-l6l24pco	180	5	influence	influence	VB
cord-350992-l6l24pco	180	6	Sars	Sars	NNP
cord-350992-l6l24pco	180	7	-	-	HYPH
cord-350992-l6l24pco	180	8	Cov-2	Cov-2	NNP
cord-350992-l6l24pco	180	9	life	life	NN
cord-350992-l6l24pco	180	10	cycle	cycle	NN
cord-350992-l6l24pco	180	11	,	,	,
cord-350992-l6l24pco	180	12	although	although	IN
cord-350992-l6l24pco	180	13	currently	currently	RB
cord-350992-l6l24pco	180	14	there	there	EX
cord-350992-l6l24pco	180	15	is	be	VBZ
cord-350992-l6l24pco	180	16	no	no	DT
cord-350992-l6l24pco	180	17	experimental	experimental	JJ
cord-350992-l6l24pco	180	18	evidence	evidence	NN
cord-350992-l6l24pco	180	19	in	in	IN
cord-350992-l6l24pco	180	20	this	this	DT
cord-350992-l6l24pco	180	21	new	new	JJ
cord-350992-l6l24pco	180	22	pandemic	pandemic	NN
cord-350992-l6l24pco	180	23	infection	infection	NN
cord-350992-l6l24pco	180	24	,	,	,
cord-350992-l6l24pco	180	25	but	but	CC
cord-350992-l6l24pco	180	26	we	-PRON-	PRP
cord-350992-l6l24pco	180	27	suggest	suggest	VBP
cord-350992-l6l24pco	180	28	research	research	NN
cord-350992-l6l24pco	180	29	in	in	IN
cord-350992-l6l24pco	180	30	this	this	DT
cord-350992-l6l24pco	180	31	direction	direction	NN
cord-350992-l6l24pco	180	32	.	.	.
cord-350992-l6l24pco	181	1	Sars	Sars	NNP
cord-350992-l6l24pco	181	2	-	-	HYPH
cord-350992-l6l24pco	181	3	Cov-2	Cov-2	NNP
cord-350992-l6l24pco	181	4	enter	enter	VBP
cord-350992-l6l24pco	181	5	cells	cell	NNS
cord-350992-l6l24pco	181	6	through	through	IN
cord-350992-l6l24pco	181	7	ACE2	ACE2	NNP
cord-350992-l6l24pco	181	8	receptor	receptor	NN
cord-350992-l6l24pco	181	9	that	that	WDT
cord-350992-l6l24pco	181	10	is	be	VBZ
cord-350992-l6l24pco	181	11	expressed	express	VBN
cord-350992-l6l24pco	181	12	broadly	broadly	RB
cord-350992-l6l24pco	181	13	in	in	IN
cord-350992-l6l24pco	181	14	the	the	DT
cord-350992-l6l24pco	181	15	human	human	JJ
cord-350992-l6l24pco	181	16	body	body	NN
cord-350992-l6l24pco	181	17	,	,	,
cord-350992-l6l24pco	181	18	mainly	mainly	RB
cord-350992-l6l24pco	181	19	in	in	IN
cord-350992-l6l24pco	181	20	the	the	DT
cord-350992-l6l24pco	181	21	vascular	vascular	JJ
cord-350992-l6l24pco	181	22	endothelia	endothelia	NNP
cord-350992-l6l24pco	181	23	,	,	,
cord-350992-l6l24pco	181	24	gastrointestinal	gastrointestinal	JJ
cord-350992-l6l24pco	181	25	system	system	NN
cord-350992-l6l24pco	181	26	,	,	,
cord-350992-l6l24pco	181	27	heart	heart	NN
cord-350992-l6l24pco	181	28	,	,	,
cord-350992-l6l24pco	181	29	kidney	kidney	NN
cord-350992-l6l24pco	181	30	,	,	,
cord-350992-l6l24pco	181	31	muscle	muscle	NN
cord-350992-l6l24pco	181	32	,	,	,
cord-350992-l6l24pco	181	33	skin	skin	NN
cord-350992-l6l24pco	181	34	and	and	CC
cord-350992-l6l24pco	181	35	bronchial	bronchial	NN
cord-350992-l6l24pco	181	36	and	and	CC
cord-350992-l6l24pco	181	37	lung	lung	NN
cord-350992-l6l24pco	181	38	alveolar	alveolar	NN
cord-350992-l6l24pco	181	39	epithelial	epithelial	JJ
cord-350992-l6l24pco	181	40	cells	cell	NNS
cord-350992-l6l24pco	181	41	[	[	-LRB-
cord-350992-l6l24pco	181	42	113	113	CD
cord-350992-l6l24pco	181	43	]	]	-RRB-
cord-350992-l6l24pco	181	44	.	.	.
cord-350992-l6l24pco	182	1	In	in	IN
cord-350992-l6l24pco	182	2	all	all	DT
cord-350992-l6l24pco	182	3	human	human	JJ
cord-350992-l6l24pco	182	4	cells	cell	NNS
cord-350992-l6l24pco	182	5	,	,	,
cord-350992-l6l24pco	182	6	then	then	RB
cord-350992-l6l24pco	182	7	also	also	RB
cord-350992-l6l24pco	182	8	Sars	Sars	NNP
cord-350992-l6l24pco	182	9	-	-	HYPH
cord-350992-l6l24pco	182	10	Cov-2	Cov-2	NNP
cord-350992-l6l24pco	182	11	target	target	NN
cord-350992-l6l24pco	182	12	cells	cell	NNS
cord-350992-l6l24pco	182	13	,	,	,
cord-350992-l6l24pco	182	14	iron	iron	NN
cord-350992-l6l24pco	182	15	is	be	VBZ
cord-350992-l6l24pco	182	16	a	a	DT
cord-350992-l6l24pco	182	17	cofactor	cofactor	NN
cord-350992-l6l24pco	182	18	of	of	IN
cord-350992-l6l24pco	182	19	several	several	JJ
cord-350992-l6l24pco	182	20	crucial	crucial	JJ
cord-350992-l6l24pco	182	21	proteins	protein	NNS
cord-350992-l6l24pco	182	22	,	,	,
cord-350992-l6l24pco	182	23	involved	involve	VBN
cord-350992-l6l24pco	182	24	in	in	IN
cord-350992-l6l24pco	182	25	bioenergetics	bioenergetic	NNS
cord-350992-l6l24pco	182	26	,	,	,
cord-350992-l6l24pco	182	27	cellular	cellular	JJ
cord-350992-l6l24pco	182	28	growth	growth	NN
cord-350992-l6l24pco	182	29	and	and	CC
cord-350992-l6l24pco	182	30	 	 	_SP
cord-350992-l6l24pco	182	31	A	a	DT
cord-350992-l6l24pco	182	32	second	second	JJ
cord-350992-l6l24pco	182	33	important	important	JJ
cord-350992-l6l24pco	182	34	point	point	NN
cord-350992-l6l24pco	182	35	raised	raise	VBN
cord-350992-l6l24pco	182	36	by	by	IN
cord-350992-l6l24pco	182	37	the	the	DT
cord-350992-l6l24pco	182	38	iron	iron	NN
cord-350992-l6l24pco	182	39	starvation	starvation	NN
cord-350992-l6l24pco	182	40	conditions	condition	NNS
cord-350992-l6l24pco	182	41	induced	induce	VBN
cord-350992-l6l24pco	182	42	by	by	IN
cord-350992-l6l24pco	182	43	CQ	CQ	NNP
cord-350992-l6l24pco	182	44	/	/	SYM
cord-350992-l6l24pco	182	45	HCQ	HCQ	NNP
cord-350992-l6l24pco	182	46	is	be	VBZ
cord-350992-l6l24pco	182	47	their	-PRON-	PRP$
cord-350992-l6l24pco	182	48	effect	effect	NN
cord-350992-l6l24pco	182	49	on	on	IN
cord-350992-l6l24pco	182	50	immune	immune	JJ
cord-350992-l6l24pco	182	51	cells	cell	NNS
cord-350992-l6l24pco	182	52	,	,	,
cord-350992-l6l24pco	182	53	involved	involve	VBN
cord-350992-l6l24pco	182	54	in	in	IN
cord-350992-l6l24pco	182	55	the	the	DT
cord-350992-l6l24pco	182	56	innate	innate	JJ
cord-350992-l6l24pco	182	57	and	and	CC
cord-350992-l6l24pco	182	58	adaptive	adaptive	JJ
cord-350992-l6l24pco	182	59	immune	immune	JJ
cord-350992-l6l24pco	182	60	responses	response	NNS
cord-350992-l6l24pco	182	61	against	against	IN
cord-350992-l6l24pco	182	62	the	the	DT
cord-350992-l6l24pco	182	63	virus	virus	NN
cord-350992-l6l24pco	182	64	.	.	.
cord-350992-l6l24pco	183	1	As	as	IN
cord-350992-l6l24pco	183	2	all	all	DT
cord-350992-l6l24pco	183	3	cells	cell	NNS
cord-350992-l6l24pco	183	4	in	in	IN
cord-350992-l6l24pco	183	5	the	the	DT
cord-350992-l6l24pco	183	6	body	body	NN
cord-350992-l6l24pco	183	7	,	,	,
cord-350992-l6l24pco	183	8	immune	immune	JJ
cord-350992-l6l24pco	183	9	cells	cell	NNS
cord-350992-l6l24pco	183	10	require	require	VBP
cord-350992-l6l24pco	183	11	iron	iron	NN
cord-350992-l6l24pco	183	12	for	for	IN
cord-350992-l6l24pco	183	13	their	-PRON-	PRP$
cord-350992-l6l24pco	183	14	proper	proper	JJ
cord-350992-l6l24pco	183	15	functions	function	NNS
cord-350992-l6l24pco	183	16	and	and	CC
cord-350992-l6l24pco	183	17	for	for	IN
cord-350992-l6l24pco	183	18	their	-PRON-	PRP$
cord-350992-l6l24pco	183	19	activation	activation	NN
cord-350992-l6l24pco	183	20	and	and	CC
cord-350992-l6l24pco	183	21	proliferation	proliferation	NN
cord-350992-l6l24pco	183	22	.	.	.
cord-350992-l6l24pco	184	1	Iron	iron	NN
cord-350992-l6l24pco	184	2	excess	excess	NN
cord-350992-l6l24pco	184	3	often	often	RB
cord-350992-l6l24pco	184	4	results	result	VBZ
cord-350992-l6l24pco	184	5	in	in	IN
cord-350992-l6l24pco	184	6	impaired	impaired	JJ
cord-350992-l6l24pco	184	7	immune	immune	JJ
cord-350992-l6l24pco	184	8	response	response	NN
cord-350992-l6l24pco	184	9	to	to	IN
cord-350992-l6l24pco	184	10	infections	infection	NNS
cord-350992-l6l24pco	184	11	,	,	,
cord-350992-l6l24pco	184	12	as	as	IN
cord-350992-l6l24pco	184	13	observed	observe	VBN
cord-350992-l6l24pco	184	14	in	in	IN
cord-350992-l6l24pco	184	15	patients	patient	NNS
cord-350992-l6l24pco	184	16	suffering	suffer	VBG
cord-350992-l6l24pco	184	17	from	from	IN
cord-350992-l6l24pco	184	18	hemochromatosis	hemochromatosis	NN
cord-350992-l6l24pco	184	19	(	(	-LRB-
cord-350992-l6l24pco	184	20	HH	HH	NNP
cord-350992-l6l24pco	184	21	)	)	-RRB-
cord-350992-l6l24pco	184	22	or	or	CC
cord-350992-l6l24pco	184	23	thalassemia	thalassemia	NN
cord-350992-l6l24pco	184	24	[	[	-LRB-
cord-350992-l6l24pco	184	25	116	116	CD
cord-350992-l6l24pco	184	26	]	]	-RRB-
cord-350992-l6l24pco	184	27	.	.	.
cord-350992-l6l24pco	185	1	Excessive	excessive	JJ
cord-350992-l6l24pco	185	2	or	or	CC
cord-350992-l6l24pco	185	3	dysregulated	dysregulated	JJ
cord-350992-l6l24pco	185	4	immune	immune	JJ
cord-350992-l6l24pco	185	5	response	response	NN
cord-350992-l6l24pco	185	6	is	be	VBZ
cord-350992-l6l24pco	185	7	of	of	IN
cord-350992-l6l24pco	185	8	particular	particular	JJ
cord-350992-l6l24pco	185	9	importance	importance	NN
cord-350992-l6l24pco	185	10	in	in	IN
cord-350992-l6l24pco	185	11	the	the	DT
cord-350992-l6l24pco	185	12	pathogenesis	pathogenesis	NN
cord-350992-l6l24pco	185	13	of	of	IN
cord-350992-l6l24pco	185	14	COVID-19	COVID-19	NNP
cord-350992-l6l24pco	185	15	[	[	-LRB-
cord-350992-l6l24pco	185	16	117	117	CD
cord-350992-l6l24pco	185	17	]	]	-RRB-
cord-350992-l6l24pco	185	18	and	and	CC
cord-350992-l6l24pco	185	19	diseases	disease	NNS
cord-350992-l6l24pco	185	20	caused	cause	VBN
cord-350992-l6l24pco	185	21	by	by	IN
cord-350992-l6l24pco	185	22	other	other	JJ
cord-350992-l6l24pco	185	23	coronaviruses	coronaviruse	NNS
cord-350992-l6l24pco	185	24	[	[	-LRB-
cord-350992-l6l24pco	185	25	118	118	CD
cord-350992-l6l24pco	185	26	]	]	-RRB-
cord-350992-l6l24pco	185	27	[	[	-LRB-
cord-350992-l6l24pco	185	28	119	119	CD
cord-350992-l6l24pco	185	29	]	]	-RRB-
cord-350992-l6l24pco	185	30	[	[	-LRB-
cord-350992-l6l24pco	185	31	120	120	CD
cord-350992-l6l24pco	185	32	]	]	-RRB-
cord-350992-l6l24pco	185	33	.	.	.
cord-350992-l6l24pco	186	1	Direct	direct	JJ
cord-350992-l6l24pco	186	2	infection	infection	NN
cord-350992-l6l24pco	186	3	of	of	IN
cord-350992-l6l24pco	186	4	innate	innate	JJ
cord-350992-l6l24pco	186	5	and	and	CC
cord-350992-l6l24pco	186	6	adaptive	adaptive	JJ
cord-350992-l6l24pco	186	7	immune	immune	JJ
cord-350992-l6l24pco	186	8	cells	cell	NNS
cord-350992-l6l24pco	186	9	has	have	VBZ
cord-350992-l6l24pco	186	10	been	be	VBN
cord-350992-l6l24pco	186	11	described	describe	VBN
cord-350992-l6l24pco	186	12	in	in	IN
cord-350992-l6l24pco	186	13	some	some	DT
cord-350992-l6l24pco	186	14	coronavirus	coronavirus	NN
cord-350992-l6l24pco	186	15	infections	infection	NNS
cord-350992-l6l24pco	186	16	[	[	-LRB-
cord-350992-l6l24pco	186	17	118	118	CD
cord-350992-l6l24pco	186	18	,	,	,
cord-350992-l6l24pco	186	19	119	119	CD
cord-350992-l6l24pco	186	20	]	]	-RRB-
cord-350992-l6l24pco	186	21	,	,	,
cord-350992-l6l24pco	186	22	then	then	RB
cord-350992-l6l24pco	186	23	iron	iron	NN
cord-350992-l6l24pco	186	24	starvation	starvation	NN
cord-350992-l6l24pco	186	25	could	could	MD
cord-350992-l6l24pco	186	26	also	also	RB
cord-350992-l6l24pco	186	27	possibly	possibly	RB
cord-350992-l6l24pco	186	28	inhibit	inhibit	VB
cord-350992-l6l24pco	186	29	these	these	DT
cord-350992-l6l24pco	186	30	infections	infection	NNS
cord-350992-l6l24pco	186	31	.	.	.
cord-350992-l6l24pco	187	1	Resident	resident	JJ
cord-350992-l6l24pco	187	2	macrophages	macrophage	NNS
cord-350992-l6l24pco	187	3	can	can	MD
cord-350992-l6l24pco	187	4	polarize	polarize	VB
cord-350992-l6l24pco	187	5	under	under	IN
cord-350992-l6l24pco	187	6	the	the	DT
cord-350992-l6l24pco	187	7	stimuli	stimulus	NNS
cord-350992-l6l24pco	187	8	of	of	IN
cord-350992-l6l24pco	187	9	cytokines	cytokine	NNS
cord-350992-l6l24pco	187	10	in	in	IN
cord-350992-l6l24pco	187	11	classically	classically	RB
cord-350992-l6l24pco	187	12	activated	activate	VBN
cord-350992-l6l24pco	187	13	pro	pro	JJ
cord-350992-l6l24pco	187	14	-	-	JJ
cord-350992-l6l24pco	187	15	inflammatory	inflammatory	JJ
cord-350992-l6l24pco	187	16	macrophages	macrophage	NNS
cord-350992-l6l24pco	187	17	(	(	-LRB-
cord-350992-l6l24pco	187	18	M1	M1	NNP
cord-350992-l6l24pco	187	19	)	)	-RRB-
cord-350992-l6l24pco	187	20	,	,	,
cord-350992-l6l24pco	187	21	induced	induce	VBN
cord-350992-l6l24pco	187	22	by	by	IN
cord-350992-l6l24pco	187	23	interferon-	interferon-	''
cord-350992-l6l24pco	187	24	(	(	-LRB-
cord-350992-l6l24pco	187	25	IFN-	IFN-	NNP
cord-350992-l6l24pco	187	26	)	)	-RRB-
cord-350992-l6l24pco	187	27	and	and	CC
cord-350992-l6l24pco	187	28	TNF-	TNF-	NNP
cord-350992-l6l24pco	187	29	or	or	CC
cord-350992-l6l24pco	187	30	,	,	,
cord-350992-l6l24pco	187	31	under	under	IN
cord-350992-l6l24pco	187	32	interleukin-4	interleukin-4	NNP
cord-350992-l6l24pco	187	33	(	(	-LRB-
cord-350992-l6l24pco	187	34	IL-4	IL-4	NNP
cord-350992-l6l24pco	187	35	)	)	-RRB-
cord-350992-l6l24pco	187	36	and	and	CC
cord-350992-l6l24pco	187	37	13	13	CD
cord-350992-l6l24pco	187	38	(	(	-LRB-
cord-350992-l6l24pco	187	39	IL-13	IL-13	NNP
cord-350992-l6l24pco	187	40	)	)	-RRB-
cord-350992-l6l24pco	187	41	stimuli	stimulus	NNS
cord-350992-l6l24pco	187	42	,	,	,
cord-350992-l6l24pco	187	43	alternatively	alternatively	RB
cord-350992-l6l24pco	187	44	activated	activate	VBN
cord-350992-l6l24pco	187	45	macrophages	macrophage	NNS
cord-350992-l6l24pco	187	46	(	(	-LRB-
cord-350992-l6l24pco	187	47	M2	M2	NNP
cord-350992-l6l24pco	187	48	)	)	-RRB-
cord-350992-l6l24pco	187	49	,	,	,
cord-350992-l6l24pco	187	50	involved	involve	VBN
cord-350992-l6l24pco	187	51	in	in	IN
cord-350992-l6l24pco	187	52	pathogen	pathogen	NN
cord-350992-l6l24pco	187	53	clearance	clearance	NN
cord-350992-l6l24pco	187	54	,	,	,
cord-350992-l6l24pco	187	55	tissue	tissue	NN
cord-350992-l6l24pco	187	56	repair	repair	NN
cord-350992-l6l24pco	187	57	and	and	CC
cord-350992-l6l24pco	187	58	inflammation	inflammation	NN
cord-350992-l6l24pco	187	59	reduction	reduction	NN
cord-350992-l6l24pco	187	60	.	.	.
cord-350992-l6l24pco	188	1	While	while	IN
cord-350992-l6l24pco	188	2	M2	m2	JJ
cord-350992-l6l24pco	188	3	macrophages	macrophage	NNS
cord-350992-l6l24pco	188	4	have	have	VBP
cord-350992-l6l24pco	188	5	low	low	JJ
cord-350992-l6l24pco	188	6	iron	iron	NN
cord-350992-l6l24pco	188	7	levels	level	NNS
cord-350992-l6l24pco	188	8	,	,	,
cord-350992-l6l24pco	188	9	M1	M1	NNP
cord-350992-l6l24pco	188	10	macrophages	macrophage	NNS
cord-350992-l6l24pco	188	11	are	be	VBP
cord-350992-l6l24pco	188	12	characterized	characterize	VBN
cord-350992-l6l24pco	188	13	by	by	IN
cord-350992-l6l24pco	188	14	iron	iron	NN
cord-350992-l6l24pco	188	15	retention	retention	NN
cord-350992-l6l24pco	188	16	,	,	,
cord-350992-l6l24pco	188	17	secrete	secrete	JJ
cord-350992-l6l24pco	188	18	high	high	JJ
cord-350992-l6l24pco	188	19	levels	level	NNS
cord-350992-l6l24pco	188	20	of	of	IN
cord-350992-l6l24pco	188	21	pro	pro	JJ
cord-350992-l6l24pco	188	22	-	-	JJ
cord-350992-l6l24pco	188	23	inflammatory	inflammatory	JJ
cord-350992-l6l24pco	188	24	cytokines	cytokine	NNS
cord-350992-l6l24pco	188	25	,	,	,
cord-350992-l6l24pco	188	26	produce	produce	VBP
cord-350992-l6l24pco	188	27	high	high	JJ
cord-350992-l6l24pco	188	28	amounts	amount	NNS
cord-350992-l6l24pco	188	29	of	of	IN
cord-350992-l6l24pco	188	30	radicals	radical	NNS
cord-350992-l6l24pco	188	31	to	to	TO
cord-350992-l6l24pco	188	32	kill	kill	VB
cord-350992-l6l24pco	188	33	pathogens	pathogen	NNS
cord-350992-l6l24pco	188	34	and	and	CC
cord-350992-l6l24pco	188	35	produce	produce	VB
cord-350992-l6l24pco	188	36	HAMP	HAMP	NNP
cord-350992-l6l24pco	188	37	that	that	WDT
cord-350992-l6l24pco	188	38	acts	act	VBZ
cord-350992-l6l24pco	188	39	in	in	IN
cord-350992-l6l24pco	188	40	an	an	DT
cord-350992-l6l24pco	188	41	autocrine	autocrine	JJ
cord-350992-l6l24pco	188	42	manner	manner	NN
cord-350992-l6l24pco	188	43	to	to	TO
cord-350992-l6l24pco	188	44	minimize	minimize	VB
cord-350992-l6l24pco	188	45	iron	iron	NN
cord-350992-l6l24pco	188	46	exit	exit	NN
cord-350992-l6l24pco	188	47	.	.	.
cord-350992-l6l24pco	189	1	Increased	increase	VBN
cord-350992-l6l24pco	189	2	iron	iron	NN
cord-350992-l6l24pco	189	3	deposition	deposition	NN
cord-350992-l6l24pco	189	4	in	in	IN
cord-350992-l6l24pco	189	5	macrophages	macrophage	NNS
cord-350992-l6l24pco	189	6	has	have	VBZ
cord-350992-l6l24pco	189	7	been	be	VBN
cord-350992-l6l24pco	189	8	shown	show	VBN
cord-350992-l6l24pco	189	9	to	to	TO
cord-350992-l6l24pco	189	10	induce	induce	VB
cord-350992-l6l24pco	189	11	M1	M1	NNP
cord-350992-l6l24pco	189	12	polarization	polarization	NN
cord-350992-l6l24pco	189	13	and	and	CC
cord-350992-l6l24pco	189	14	the	the	DT
cord-350992-l6l24pco	189	15	persistence	persistence	NN
cord-350992-l6l24pco	189	16	of	of	IN
cord-350992-l6l24pco	189	17	a	a	DT
cord-350992-l6l24pco	189	18	pro	pro	JJ
cord-350992-l6l24pco	189	19	-	-	JJ
cord-350992-l6l24pco	189	20	inflammatory	inflammatory	JJ
cord-350992-l6l24pco	189	21	state	state	NN
cord-350992-l6l24pco	189	22	due	due	IN
cord-350992-l6l24pco	189	23	to	to	IN
cord-350992-l6l24pco	189	24	an	an	DT
cord-350992-l6l24pco	189	25	incomplete	incomplete	JJ
cord-350992-l6l24pco	189	26	switch	switch	NN
cord-350992-l6l24pco	189	27	to	to	IN
cord-350992-l6l24pco	189	28	M2	m2	JJ
cord-350992-l6l24pco	189	29	state	state	NN
cord-350992-l6l24pco	189	30	[	[	-LRB-
cord-350992-l6l24pco	189	31	121	121	CD
cord-350992-l6l24pco	189	32	]	]	-RRB-
cord-350992-l6l24pco	189	33	.	.	.
cord-350992-l6l24pco	190	1	Iron	iron	NN
cord-350992-l6l24pco	190	2	retention	retention	NN
cord-350992-l6l24pco	190	3	in	in	IN
cord-350992-l6l24pco	190	4	macrophages	macrophage	NNS
cord-350992-l6l24pco	190	5	could	could	MD
cord-350992-l6l24pco	190	6	then	then	RB
cord-350992-l6l24pco	190	7	favor	favor	VB
cord-350992-l6l24pco	190	8	intracellular	intracellular	JJ
cord-350992-l6l24pco	190	9	virus	virus	NN
cord-350992-l6l24pco	190	10	life	life	NN
cord-350992-l6l24pco	190	11	cycle	cycle	NN
cord-350992-l6l24pco	190	12	in	in	IN
cord-350992-l6l24pco	190	13	the	the	DT
cord-350992-l6l24pco	190	14	case	case	NN
cord-350992-l6l24pco	190	15	of	of	IN
cord-350992-l6l24pco	190	16	their	-PRON-	PRP$
cord-350992-l6l24pco	190	17	infection	infection	NN
cord-350992-l6l24pco	190	18	and	and	CC
cord-350992-l6l24pco	190	19	further	further	RB
cord-350992-l6l24pco	190	20	promote	promote	VB
cord-350992-l6l24pco	190	21	the	the	DT
cord-350992-l6l24pco	190	22	process	process	NN
cord-350992-l6l24pco	190	23	of	of	IN
cord-350992-l6l24pco	190	24	inflammation	inflammation	NN
cord-350992-l6l24pco	190	25	,	,	,
cord-350992-l6l24pco	190	26	while	while	IN
cord-350992-l6l24pco	190	27	iron	iron	NN
cord-350992-l6l24pco	190	28	starvation	starvation	NN
cord-350992-l6l24pco	190	29	could	could	MD
cord-350992-l6l24pco	190	30	result	result	VB
cord-350992-l6l24pco	190	31	in	in	IN
cord-350992-l6l24pco	190	32	the	the	DT
cord-350992-l6l24pco	190	33	opposite	opposite	JJ
cord-350992-l6l24pco	190	34	effects	effect	NNS
cord-350992-l6l24pco	190	35	.	.	.
cord-350992-l6l24pco	191	1	Further	further	RB
cord-350992-l6l24pco	191	2	,	,	,
cord-350992-l6l24pco	191	3	iron	iron	NN
cord-350992-l6l24pco	191	4	excess	excess	NN
cord-350992-l6l24pco	191	5	in	in	IN
cord-350992-l6l24pco	191	6	macrophages	macrophage	NNS
cord-350992-l6l24pco	191	7	favors	favor	VBZ
cord-350992-l6l24pco	191	8	secondary	secondary	JJ
cord-350992-l6l24pco	191	9	infections	infection	NNS
cord-350992-l6l24pco	191	10	with	with	IN
cord-350992-l6l24pco	191	11	other	other	JJ
cord-350992-l6l24pco	191	12	J	J	NNP
cord-350992-l6l24pco	191	13	o	o	NN
cord-350992-l6l24pco	191	14	u	u	NN
cord-350992-l6l24pco	191	15	r	r	NN
cord-350992-l6l24pco	191	16	n	n	NN
cord-350992-l6l24pco	191	17	a	a	DT
cord-350992-l6l24pco	191	18	l	l	NN
cord-350992-l6l24pco	191	19	P	p	NN
cord-350992-l6l24pco	191	20	r	r	NN
cord-350992-l6l24pco	191	21	e	e	NN
cord-350992-l6l24pco	191	22	-p	-p	NN
cord-350992-l6l24pco	192	1	r	r	LS
cord-350992-l6l24pco	193	1	o	o	UH
cord-350992-l6l24pco	194	1	o	o	UH
cord-350992-l6l24pco	194	2	f	f	CD
cord-350992-l6l24pco	194	3	microbes	microbe	NNS
cord-350992-l6l24pco	194	4	.	.	.
cord-350992-l6l24pco	195	1	Chronic	chronic	JJ
cord-350992-l6l24pco	195	2	administration	administration	NN
cord-350992-l6l24pco	195	3	of	of	IN
cord-350992-l6l24pco	195	4	CQ	CQ	NNP
cord-350992-l6l24pco	195	5	has	have	VBZ
cord-350992-l6l24pco	195	6	been	be	VBN
cord-350992-l6l24pco	195	7	shown	show	VBN
cord-350992-l6l24pco	195	8	to	to	TO
cord-350992-l6l24pco	195	9	decrease	decrease	VB
cord-350992-l6l24pco	195	10	iron	iron	NN
cord-350992-l6l24pco	195	11	content	content	NN
cord-350992-l6l24pco	195	12	in	in	IN
cord-350992-l6l24pco	195	13	a	a	DT
cord-350992-l6l24pco	195	14	rat	rat	NN
cord-350992-l6l24pco	195	15	model	model	NN
cord-350992-l6l24pco	195	16	.	.	.
cord-350992-l6l24pco	196	1	Legssyer	Legssyer	NNP
cord-350992-l6l24pco	196	2	and	and	CC
cord-350992-l6l24pco	196	3	colleagues	colleague	NNS
cord-350992-l6l24pco	196	4	[	[	-LRB-
cord-350992-l6l24pco	196	5	1232	1232	CD
cord-350992-l6l24pco	196	6	,	,	,
cord-350992-l6l24pco	196	7	123	123	CD
cord-350992-l6l24pco	196	8	]	]	-RRB-
cord-350992-l6l24pco	196	9	showed	show	VBD
cord-350992-l6l24pco	196	10	that	that	IN
cord-350992-l6l24pco	196	11	CQ	CQ	NNP
cord-350992-l6l24pco	196	12	decreased	decrease	VBD
cord-350992-l6l24pco	196	13	iron	iron	NN
cord-350992-l6l24pco	196	14	content	content	NN
cord-350992-l6l24pco	196	15	in	in	IN
cord-350992-l6l24pco	196	16	the	the	DT
cord-350992-l6l24pco	196	17	liver	liver	NN
cord-350992-l6l24pco	196	18	of	of	IN
cord-350992-l6l24pco	196	19	control	control	NN
cord-350992-l6l24pco	196	20	,	,	,
cord-350992-l6l24pco	196	21	iron	iron	NN
cord-350992-l6l24pco	196	22	-	-	HYPH
cord-350992-l6l24pco	196	23	loaded	load	VBN
cord-350992-l6l24pco	196	24	and	and	CC
cord-350992-l6l24pco	196	25	iron	iron	NN
cord-350992-l6l24pco	196	26	-	-	HYPH
cord-350992-l6l24pco	196	27	deficient	deficient	JJ
cord-350992-l6l24pco	196	28	rats	rat	NNS
cord-350992-l6l24pco	196	29	,	,	,
cord-350992-l6l24pco	196	30	in	in	IN
cord-350992-l6l24pco	196	31	the	the	DT
cord-350992-l6l24pco	196	32	spleen	spleen	NNS
cord-350992-l6l24pco	196	33	of	of	IN
cord-350992-l6l24pco	196	34	control	control	NN
cord-350992-l6l24pco	196	35	and	and	CC
cord-350992-l6l24pco	196	36	iron	iron	NN
cord-350992-l6l24pco	196	37	-	-	HYPH
cord-350992-l6l24pco	196	38	loaded	load	VBN
cord-350992-l6l24pco	196	39	animals	animal	NNS
cord-350992-l6l24pco	196	40	and	and	CC
cord-350992-l6l24pco	196	41	,	,	,
cord-350992-l6l24pco	196	42	importantly	importantly	RB
cord-350992-l6l24pco	196	43	,	,	,
cord-350992-l6l24pco	196	44	in	in	IN
cord-350992-l6l24pco	196	45	alveolar	alveolar	JJ
cord-350992-l6l24pco	196	46	macrophages	macrophage	NNS
cord-350992-l6l24pco	196	47	of	of	IN
cord-350992-l6l24pco	196	48	iron	iron	NN
cord-350992-l6l24pco	196	49	-	-	HYPH
cord-350992-l6l24pco	196	50	loaded	load	VBN
cord-350992-l6l24pco	196	51	rats	rat	NNS
cord-350992-l6l24pco	196	52	.	.	.
cord-350992-l6l24pco	197	1	They	-PRON-	PRP
cord-350992-l6l24pco	197	2	also	also	RB
cord-350992-l6l24pco	197	3	interestingly	interestingly	RB
cord-350992-l6l24pco	197	4	observed	observe	VBD
cord-350992-l6l24pco	197	5	that	that	IN
cord-350992-l6l24pco	197	6	CQ	CQ	NNP
cord-350992-l6l24pco	197	7	treatment	treatment	NN
cord-350992-l6l24pco	197	8	of	of	IN
cord-350992-l6l24pco	197	9	primary	primary	JJ
cord-350992-l6l24pco	197	10	cultures	culture	NNS
cord-350992-l6l24pco	197	11	of	of	IN
cord-350992-l6l24pco	197	12	alveolar	alveolar	JJ
cord-350992-l6l24pco	197	13	macrophages	macrophage	NNS
cord-350992-l6l24pco	197	14	obtained	obtain	VBN
cord-350992-l6l24pco	197	15	from	from	IN
cord-350992-l6l24pco	197	16	all	all	DT
cord-350992-l6l24pco	197	17	three	three	CD
cord-350992-l6l24pco	197	18	groups	group	NNS
cord-350992-l6l24pco	197	19	of	of	IN
cord-350992-l6l24pco	197	20	rats	rat	NNS
cord-350992-l6l24pco	197	21	and	and	CC
cord-350992-l6l24pco	197	22	treated	treat	VBN
cord-350992-l6l24pco	197	23	with	with	IN
cord-350992-l6l24pco	197	24	lipopolysaccharide	lipopolysaccharide	NN
cord-350992-l6l24pco	197	25	(	(	-LRB-
cord-350992-l6l24pco	197	26	LPS	LPS	NNP
cord-350992-l6l24pco	197	27	)	)	-RRB-
cord-350992-l6l24pco	197	28	significatively	significatively	RB
cord-350992-l6l24pco	197	29	reduced	reduce	VBD
cord-350992-l6l24pco	197	30	the	the	DT
cord-350992-l6l24pco	197	31	oxidative	oxidative	JJ
cord-350992-l6l24pco	197	32	response	response	NN
cord-350992-l6l24pco	197	33	,	,	,
cord-350992-l6l24pco	197	34	measured	measure	VBN
cord-350992-l6l24pco	197	35	by	by	IN
cord-350992-l6l24pco	197	36	NO	no	DT
cord-350992-l6l24pco	197	37	2	2	CD
cord-350992-l6l24pco	197	38	release	release	NN
cord-350992-l6l24pco	197	39	,	,	,
cord-350992-l6l24pco	197	40	suggesting	suggest	VBG
cord-350992-l6l24pco	197	41	that	that	IN
cord-350992-l6l24pco	197	42	CQ	CQ	NNP
cord-350992-l6l24pco	197	43	might	may	MD
cord-350992-l6l24pco	197	44	prevent	prevent	VB
cord-350992-l6l24pco	197	45	infections	infection	NNS
cord-350992-l6l24pco	197	46	,	,	,
cord-350992-l6l24pco	197	47	particularly	particularly	RB
cord-350992-l6l24pco	197	48	those	those	DT
cord-350992-l6l24pco	197	49	associated	associate	VBN
cord-350992-l6l24pco	197	50	with	with	IN
cord-350992-l6l24pco	197	51	diseases	disease	NNS
cord-350992-l6l24pco	197	52	characterized	characterize	VBN
cord-350992-l6l24pco	197	53	by	by	IN
cord-350992-l6l24pco	197	54	iron	iron	NN
cord-350992-l6l24pco	197	55	overload	overload	NN
cord-350992-l6l24pco	197	56	,	,	,
cord-350992-l6l24pco	197	57	through	through	IN
cord-350992-l6l24pco	197	58	limiting	limit	VBG
cord-350992-l6l24pco	197	59	iron	iron	NN
cord-350992-l6l24pco	197	60	availability	availability	NN
cord-350992-l6l24pco	197	61	not	not	RB
cord-350992-l6l24pco	197	62	only	only	RB
cord-350992-l6l24pco	197	63	in	in	IN
cord-350992-l6l24pco	197	64	infected	infected	JJ
cord-350992-l6l24pco	197	65	cells	cell	NNS
cord-350992-l6l24pco	197	66	but	but	CC
cord-350992-l6l24pco	197	67	also	also	RB
cord-350992-l6l24pco	197	68	in	in	IN
cord-350992-l6l24pco	197	69	macrophages	macrophage	NNS
cord-350992-l6l24pco	197	70	,	,	,
cord-350992-l6l24pco	197	71	in	in	IN
cord-350992-l6l24pco	197	72	turn	turn	NN
cord-350992-l6l24pco	197	73	reducing	reduce	VBG
cord-350992-l6l24pco	197	74	inflammation	inflammation	NN
cord-350992-l6l24pco	197	75	.	.	.
cord-350992-l6l24pco	198	1	However	however	RB
cord-350992-l6l24pco	198	2	,	,	,
cord-350992-l6l24pco	198	3	heterozygous	heterozygous	JJ
cord-350992-l6l24pco	198	4	and	and	CC
cord-350992-l6l24pco	198	5	homozygous	homozygous	JJ
cord-350992-l6l24pco	198	6	mutations	mutation	NNS
cord-350992-l6l24pco	198	7	in	in	IN
cord-350992-l6l24pco	198	8	the	the	DT
cord-350992-l6l24pco	198	9	hemochromatosis	hemochromatosis	NN
cord-350992-l6l24pco	198	10	gene	gene	NN
cord-350992-l6l24pco	198	11	(	(	-LRB-
cord-350992-l6l24pco	198	12	HFE	HFE	NNP
cord-350992-l6l24pco	198	13	)	)	-RRB-
cord-350992-l6l24pco	198	14	reduce	reduce	VB
cord-350992-l6l24pco	198	15	the	the	DT
cord-350992-l6l24pco	198	16	CQ	CQ	NNP
cord-350992-l6l24pco	198	17	effect	effect	NN
cord-350992-l6l24pco	198	18	of	of	IN
cord-350992-l6l24pco	198	19	iron	iron	NN
cord-350992-l6l24pco	198	20	removal	removal	NN
cord-350992-l6l24pco	198	21	in	in	IN
cord-350992-l6l24pco	198	22	porphyria	porphyria	NNP
cord-350992-l6l24pco	198	23	cutanea	cutanea	NNP
cord-350992-l6l24pco	198	24	tarda	tarda	NNP
cord-350992-l6l24pco	198	25	[	[	-LRB-
cord-350992-l6l24pco	198	26	124	124	CD
cord-350992-l6l24pco	198	27	]	]	-RRB-
cord-350992-l6l24pco	198	28	.	.	.
cord-350992-l6l24pco	199	1	Also	also	RB
cord-350992-l6l24pco	199	2	in	in	IN
cord-350992-l6l24pco	199	3	murine	murine	JJ
cord-350992-l6l24pco	199	4	models	model	NNS
cord-350992-l6l24pco	199	5	,	,	,
cord-350992-l6l24pco	199	6	CQ	CQ	NNP
cord-350992-l6l24pco	199	7	has	have	VBZ
cord-350992-l6l24pco	199	8	been	be	VBN
cord-350992-l6l24pco	199	9	shown	show	VBN
cord-350992-l6l24pco	199	10	to	to	TO
cord-350992-l6l24pco	199	11	decrease	decrease	VB
cord-350992-l6l24pco	199	12	macrophage	macrophage	NN
cord-350992-l6l24pco	199	13	activation	activation	NN
cord-350992-l6l24pco	199	14	syndrome	syndrome	NN
cord-350992-l6l24pco	199	15	(	(	-LRB-
cord-350992-l6l24pco	199	16	hemophagocytic	hemophagocytic	NNP
cord-350992-l6l24pco	199	17	syndrome	syndrome	NN
cord-350992-l6l24pco	199	18	)	)	-RRB-
cord-350992-l6l24pco	199	19	induced	induce	VBN
cord-350992-l6l24pco	199	20	by	by	IN
cord-350992-l6l24pco	199	21	pristane	pristane	NNP
cord-350992-l6l24pco	199	22	,	,	,
cord-350992-l6l24pco	199	23	by	by	IN
cord-350992-l6l24pco	199	24	reducing	reduce	VBG
cord-350992-l6l24pco	199	25	macrophage	macrophage	NN
cord-350992-l6l24pco	199	26	infiltration	infiltration	NN
cord-350992-l6l24pco	199	27	,	,	,
cord-350992-l6l24pco	199	28	phagocytic	phagocytic	JJ
cord-350992-l6l24pco	199	29	functions	function	NNS
cord-350992-l6l24pco	199	30	,	,	,
cord-350992-l6l24pco	199	31	cytokine	cytokine	NN
cord-350992-l6l24pco	199	32	production	production	NN
cord-350992-l6l24pco	199	33	and	and	CC
cord-350992-l6l24pco	199	34	reducing	reduce	VBG
cord-350992-l6l24pco	199	35	FT	FT	NNP
cord-350992-l6l24pco	199	36	,	,	,
cord-350992-l6l24pco	199	37	lactate	lactate	NN
cord-350992-l6l24pco	199	38	dehydrogenase	dehydrogenase	NN
cord-350992-l6l24pco	199	39	and	and	CC
cord-350992-l6l24pco	199	40	triglyceride	triglyceride	NN
cord-350992-l6l24pco	199	41	levels	level	NNS
cord-350992-l6l24pco	199	42	[	[	-LRB-
cord-350992-l6l24pco	199	43	125	125	CD
cord-350992-l6l24pco	199	44	]	]	-RRB-
cord-350992-l6l24pco	199	45	.	.	.
cord-350992-l6l24pco	200	1	Although	although	IN
cord-350992-l6l24pco	200	2	immune	immune	JJ
cord-350992-l6l24pco	200	3	cells	cell	NNS
cord-350992-l6l24pco	200	4	need	need	VBP
cord-350992-l6l24pco	200	5	iron	iron	NN
cord-350992-l6l24pco	200	6	for	for	IN
cord-350992-l6l24pco	200	7	their	-PRON-	PRP$
cord-350992-l6l24pco	200	8	proliferation	proliferation	NN
cord-350992-l6l24pco	200	9	and	and	CC
cord-350992-l6l24pco	200	10	activation	activation	NN
cord-350992-l6l24pco	200	11	,	,	,
cord-350992-l6l24pco	200	12	excess	excess	JJ
cord-350992-l6l24pco	200	13	iron	iron	NN
cord-350992-l6l24pco	200	14	has	have	VBZ
cord-350992-l6l24pco	200	15	also	also	RB
cord-350992-l6l24pco	200	16	been	be	VBN
cord-350992-l6l24pco	200	17	reported	report	VBN
cord-350992-l6l24pco	200	18	to	to	TO
cord-350992-l6l24pco	200	19	impair	impair	VB
cord-350992-l6l24pco	200	20	antigen	antigen	NN
cord-350992-l6l24pco	200	21	processing	processing	NN
cord-350992-l6l24pco	200	22	and	and	CC
cord-350992-l6l24pco	200	23	presentation	presentation	NN
cord-350992-l6l24pco	200	24	by	by	IN
cord-350992-l6l24pco	200	25	APCs	apc	NNS
cord-350992-l6l24pco	200	26	,	,	,
cord-350992-l6l24pco	200	27	suppress	suppress	VB
cord-350992-l6l24pco	200	28	CD4	CD4	NNP
cord-350992-l6l24pco	200	29	+	+	CC
cord-350992-l6l24pco	200	30	cells	cell	NNS
cord-350992-l6l24pco	200	31	and	and	CC
cord-350992-l6l24pco	200	32	alter	alter	VB
cord-350992-l6l24pco	200	33	CD4	CD4	NNP
cord-350992-l6l24pco	200	34	+	+	CC
cord-350992-l6l24pco	200	35	/CD8	/CD8	.
cord-350992-l6l24pco	201	1	+	+	CC
cord-350992-l6l24pco	201	2	lymphocyte	lymphocyte	NN
cord-350992-l6l24pco	201	3	ratio	ratio	NN
cord-350992-l6l24pco	201	4	,	,	,
cord-350992-l6l24pco	201	5	increase	increase	VB
cord-350992-l6l24pco	201	6	circulating	circulate	VBG
cord-350992-l6l24pco	201	7	immunoglobulin	immunoglobulin	NN
cord-350992-l6l24pco	201	8	-	-	HYPH
cord-350992-l6l24pco	201	9	producing	produce	VBG
cord-350992-l6l24pco	201	10	B	b	NN
cord-350992-l6l24pco	201	11	cells	cell	NNS
cord-350992-l6l24pco	201	12	,	,	,
cord-350992-l6l24pco	201	13	reduce	reduce	VB
cord-350992-l6l24pco	201	14	natural	natural	JJ
cord-350992-l6l24pco	201	15	killer	killer	NN
cord-350992-l6l24pco	201	16	(	(	-LRB-
cord-350992-l6l24pco	201	17	NK	NK	NNP
cord-350992-l6l24pco	201	18	)	)	-RRB-
cord-350992-l6l24pco	201	19	cell	cell	NN
cord-350992-l6l24pco	201	20	lysing	lysing	NN
cord-350992-l6l24pco	201	21	efficiency	efficiency	NN
cord-350992-l6l24pco	201	22	and	and	CC
cord-350992-l6l24pco	201	23	perturb	perturb	VB
cord-350992-l6l24pco	201	24	complement	complement	NN
cord-350992-l6l24pco	201	25	activation	activation	NN
cord-350992-l6l24pco	201	26	[	[	-LRB-
cord-350992-l6l24pco	201	27	126	126	CD
cord-350992-l6l24pco	201	28	]	]	-RRB-
cord-350992-l6l24pco	201	29	,	,	,
cord-350992-l6l24pco	201	30	while	while	IN
cord-350992-l6l24pco	201	31	iron	iron	NN
cord-350992-l6l24pco	201	32	deficiency	deficiency	NN
cord-350992-l6l24pco	201	33	has	have	VBZ
cord-350992-l6l24pco	201	34	an	an	DT
cord-350992-l6l24pco	201	35	immunosuppressive	immunosuppressive	JJ
cord-350992-l6l24pco	201	36	effect	effect	NN
cord-350992-l6l24pco	201	37	on	on	IN
cord-350992-l6l24pco	201	38	T	t	NN
cord-350992-l6l24pco	201	39	cells	cell	NNS
cord-350992-l6l24pco	201	40	[	[	-LRB-
cord-350992-l6l24pco	201	41	127	127	CD
cord-350992-l6l24pco	201	42	]	]	-RRB-
cord-350992-l6l24pco	201	43	.	.	.
cord-350992-l6l24pco	202	1	Then	then	RB
cord-350992-l6l24pco	202	2	,	,	,
cord-350992-l6l24pco	202	3	CQ	CQ	NNP
cord-350992-l6l24pco	202	4	/	/	SYM
cord-350992-l6l24pco	202	5	HCQ	HCQ	NNP
cord-350992-l6l24pco	202	6	treatment	treatment	NN
cord-350992-l6l24pco	202	7	,	,	,
cord-350992-l6l24pco	202	8	through	through	IN
cord-350992-l6l24pco	202	9	their	-PRON-	PRP$
cord-350992-l6l24pco	202	10	action	action	NN
cord-350992-l6l24pco	202	11	on	on	IN
cord-350992-l6l24pco	202	12	iron	iron	NN
cord-350992-l6l24pco	202	13	homeostasis	homeostasis	NN
cord-350992-l6l24pco	202	14	,	,	,
cord-350992-l6l24pco	202	15	could	could	MD
cord-350992-l6l24pco	202	16	possibly	possibly	RB
cord-350992-l6l24pco	202	17	have	have	VB
cord-350992-l6l24pco	202	18	also	also	RB
cord-350992-l6l24pco	202	19	a	a	DT
cord-350992-l6l24pco	202	20	broad	broad	JJ
cord-350992-l6l24pco	202	21	role	role	NN
cord-350992-l6l24pco	202	22	in	in	IN
cord-350992-l6l24pco	202	23	the	the	DT
cord-350992-l6l24pco	202	24	modulation	modulation	NN
cord-350992-l6l24pco	202	25	of	of	IN
cord-350992-l6l24pco	202	26	the	the	DT
cord-350992-l6l24pco	202	27	adaptive	adaptive	JJ
cord-350992-l6l24pco	202	28	response	response	NN
cord-350992-l6l24pco	202	29	to	to	IN
cord-350992-l6l24pco	202	30	Sars	Sars	NNP
cord-350992-l6l24pco	202	31	-	-	HYPH
cord-350992-l6l24pco	202	32	Cov-2	Cov-2	NNP
cord-350992-l6l24pco	202	33	.	.	.
cord-350992-l6l24pco	203	1	A	a	DT
cord-350992-l6l24pco	203	2	third	third	JJ
cord-350992-l6l24pco	203	3	important	important	JJ
cord-350992-l6l24pco	203	4	point	point	NN
cord-350992-l6l24pco	203	5	to	to	TO
cord-350992-l6l24pco	203	6	highlight	highlight	VB
cord-350992-l6l24pco	203	7	derives	derive	VBZ
cord-350992-l6l24pco	203	8	from	from	IN
cord-350992-l6l24pco	203	9	the	the	DT
cord-350992-l6l24pco	203	10	inhibitory	inhibitory	JJ
cord-350992-l6l24pco	203	11	action	action	NN
cord-350992-l6l24pco	203	12	of	of	IN
cord-350992-l6l24pco	203	13	CQ	CQ	NNP
cord-350992-l6l24pco	203	14	/	/	SYM
cord-350992-l6l24pco	203	15	HCQ	HCQ	NNP
cord-350992-l6l24pco	203	16	on	on	IN
cord-350992-l6l24pco	203	17	IL-1	IL-1	NNP
cord-350992-l6l24pco	204	1	,	,	,
cord-350992-l6l24pco	204	2	TNF-	TNF-	NNP
cord-350992-l6l24pco	204	3	and	and	CC
cord-350992-l6l24pco	204	4	IL-6	IL-6	NNP
cord-350992-l6l24pco	204	5	release	release	NN
cord-350992-l6l24pco	204	6	.	.	.
cord-350992-l6l24pco	205	1	First	first	RB
cord-350992-l6l24pco	205	2	,	,	,
cord-350992-l6l24pco	205	3	TNF	TNF	NNP
cord-350992-l6l24pco	205	4	-	-	HYPH
cord-350992-l6l24pco	205	5	α	α	NNP
cord-350992-l6l24pco	205	6	acts	act	NNS
cord-350992-l6l24pco	205	7	on	on	IN
cord-350992-l6l24pco	205	8	iron	iron	NN
cord-350992-l6l24pco	205	9	homeostasis	homeostasis	NN
cord-350992-l6l24pco	205	10	,	,	,
cord-350992-l6l24pco	205	11	reducing	reduce	VBG
cord-350992-l6l24pco	205	12	intestinal	intestinal	JJ
cord-350992-l6l24pco	205	13	iron	iron	NN
cord-350992-l6l24pco	205	14	absorption	absorption	NN
cord-350992-l6l24pco	205	15	and	and	CC
cord-350992-l6l24pco	205	16	blocking	block	VBG
cord-350992-l6l24pco	205	17	iron	iron	NN
cord-350992-l6l24pco	205	18	recycling	recycling	NN
cord-350992-l6l24pco	205	19	from	from	IN
cord-350992-l6l24pco	205	20	macrophages	macrophage	NNS
cord-350992-l6l24pco	205	21	,	,	,
cord-350992-l6l24pco	205	22	then	then	RB
cord-350992-l6l24pco	205	23	inducing	induce	VBG
cord-350992-l6l24pco	205	24	iron	iron	NN
cord-350992-l6l24pco	205	25	retention	retention	NN
cord-350992-l6l24pco	205	26	in	in	IN
cord-350992-l6l24pco	205	27	these	these	DT
cord-350992-l6l24pco	205	28	cells	cell	NNS
cord-350992-l6l24pco	205	29	and	and	CC
cord-350992-l6l24pco	205	30	their	-PRON-	PRP$
cord-350992-l6l24pco	205	31	polarization	polarization	NN
cord-350992-l6l24pco	205	32	to	to	IN
cord-350992-l6l24pco	205	33	M1	M1	NNP
cord-350992-l6l24pco	205	34	proinflammatory	proinflammatory	JJ
cord-350992-l6l24pco	205	35	phenotype	phenotype	NN
cord-350992-l6l24pco	205	36	[	[	-LRB-
cord-350992-l6l24pco	205	37	102	102	CD
cord-350992-l6l24pco	205	38	]	]	-RRB-
cord-350992-l6l24pco	205	39	.	.	.
cord-350992-l6l24pco	206	1	Conversely	conversely	RB
cord-350992-l6l24pco	206	2	,	,	,
cord-350992-l6l24pco	206	3	CQ	CQ	NNP
cord-350992-l6l24pco	206	4	inhibits	inhibit	VBZ
cord-350992-l6l24pco	206	5	TNF-	TNF-	NNP
cord-350992-l6l24pco	206	6	acting	act	VBG
cord-350992-l6l24pco	206	7	also	also	RB
cord-350992-l6l24pco	206	8	through	through	IN
cord-350992-l6l24pco	206	9	the	the	DT
cord-350992-l6l24pco	206	10	induction	induction	NN
cord-350992-l6l24pco	206	11	of	of	IN
cord-350992-l6l24pco	206	12	cellular	cellular	JJ
cord-350992-l6l24pco	206	13	iron	iron	NN
cord-350992-l6l24pco	206	14	starvation	starvation	NN
cord-350992-l6l24pco	206	15	[	[	-LRB-
cord-350992-l6l24pco	206	16	40	40	CD
cord-350992-l6l24pco	206	17	]	]	-RRB-
cord-350992-l6l24pco	206	18	.	.	.
cord-350992-l6l24pco	207	1	Then	then	RB
cord-350992-l6l24pco	207	2	,	,	,
cord-350992-l6l24pco	207	3	the	the	DT
cord-350992-l6l24pco	207	4	inhibition	inhibition	NN
cord-350992-l6l24pco	207	5	of	of	IN
cord-350992-l6l24pco	207	6	the	the	DT
cord-350992-l6l24pco	207	7	cytokine	cytokine	NN
cord-350992-l6l24pco	207	8	by	by	IN
cord-350992-l6l24pco	207	9	CQ	CQ	NNP
cord-350992-l6l24pco	207	10	/	/	SYM
cord-350992-l6l24pco	207	11	HCQ	HCQ	NNP
cord-350992-l6l24pco	207	12	,	,	,
cord-350992-l6l24pco	207	13	also	also	RB
cord-350992-l6l24pco	207	14	through	through	IN
cord-350992-l6l24pco	207	15	their	-PRON-	PRP$
cord-350992-l6l24pco	207	16	effect	effect	NN
cord-350992-l6l24pco	207	17	on	on	IN
cord-350992-l6l24pco	207	18	iron	iron	NN
cord-350992-l6l24pco	207	19	homeostasis	homeostasis	NN
cord-350992-l6l24pco	207	20	,	,	,
cord-350992-l6l24pco	207	21	could	could	MD
cord-350992-l6l24pco	207	22	alleviate	alleviate	VB
cord-350992-l6l24pco	207	23	inflammation	inflammation	NN
cord-350992-l6l24pco	207	24	,	,	,
cord-350992-l6l24pco	207	25	restoring	restore	VBG
cord-350992-l6l24pco	207	26	a	a	DT
cord-350992-l6l24pco	207	27	balanced	balanced	JJ
cord-350992-l6l24pco	207	28	systemic	systemic	JJ
cord-350992-l6l24pco	207	29	iron	iron	NN
cord-350992-l6l24pco	207	30	homeostasis	homeostasis	NN
cord-350992-l6l24pco	207	31	and	and	CC
cord-350992-l6l24pco	207	32	rescuing	rescue	VBG
cord-350992-l6l24pco	207	33	erythropoiesis	erythropoiesis	NN
cord-350992-l6l24pco	207	34	.	.	.
cord-350992-l6l24pco	208	1	Secondly	secondly	RB
cord-350992-l6l24pco	208	2	,	,	,
cord-350992-l6l24pco	208	3	IL-1	IL-1	NNP
cord-350992-l6l24pco	208	4	,	,	,
cord-350992-l6l24pco	208	5	TNF-	TNF-	NNP
cord-350992-l6l24pco	208	6	and	and	CC
cord-350992-l6l24pco	208	7	IL-6	IL-6	NNP
cord-350992-l6l24pco	208	8	as	as	IN
cord-350992-l6l24pco	208	9	stated	state	VBN
cord-350992-l6l24pco	208	10	above	above	RB
cord-350992-l6l24pco	208	11	,	,	,
cord-350992-l6l24pco	208	12	induce	induce	VB
cord-350992-l6l24pco	208	13	the	the	DT
cord-350992-l6l24pco	208	14	systemic	systemic	JJ
cord-350992-l6l24pco	208	15	and	and	CC
cord-350992-l6l24pco	208	16	local	local	JJ
cord-350992-l6l24pco	208	17	release	release	NN
cord-350992-l6l24pco	208	18	of	of	IN
cord-350992-l6l24pco	208	19	HAMP	HAMP	NNP
cord-350992-l6l24pco	208	20	.	.	.
cord-350992-l6l24pco	209	1	Iron	iron	NN
cord-350992-l6l24pco	209	2	is	be	VBZ
cord-350992-l6l24pco	209	3	essential	essential	JJ
cord-350992-l6l24pco	209	4	for	for	IN
cord-350992-l6l24pco	209	5	life	life	NN
cord-350992-l6l24pco	209	6	,	,	,
cord-350992-l6l24pco	209	7	but	but	CC
cord-350992-l6l24pco	209	8	excess	excess	JJ
cord-350992-l6l24pco	209	9	iron	iron	NN
cord-350992-l6l24pco	209	10	is	be	VBZ
cord-350992-l6l24pco	209	11	toxic	toxic	JJ
cord-350992-l6l24pco	209	12	,	,	,
cord-350992-l6l24pco	209	13	due	due	IN
cord-350992-l6l24pco	209	14	to	to	IN
cord-350992-l6l24pco	209	15	its	-PRON-	PRP$
cord-350992-l6l24pco	209	16	redox	redox	NN
cord-350992-l6l24pco	209	17	potential	potential	NN
cord-350992-l6l24pco	209	18	that	that	WDT
cord-350992-l6l24pco	209	19	can	can	MD
cord-350992-l6l24pco	209	20	hamper	hamper	VB
cord-350992-l6l24pco	209	21	oxidative	oxidative	JJ
cord-350992-l6l24pco	209	22	stress	stress	NN
cord-350992-l6l24pco	209	23	damaging	damage	VBG
cord-350992-l6l24pco	209	24	crucial	crucial	JJ
cord-350992-l6l24pco	209	25	cellular	cellular	JJ
cord-350992-l6l24pco	209	26	components	component	NNS
cord-350992-l6l24pco	209	27	.	.	.
cord-350992-l6l24pco	210	1	Iron	iron	NN
cord-350992-l6l24pco	210	2	availability	availability	NN
cord-350992-l6l24pco	210	3	is	be	VBZ
cord-350992-l6l24pco	210	4	then	then	RB
cord-350992-l6l24pco	210	5	tightly	tightly	RB
cord-350992-l6l24pco	210	6	regulated	regulate	VBN
cord-350992-l6l24pco	210	7	both	both	CC
cord-350992-l6l24pco	210	8	at	at	IN
cord-350992-l6l24pco	210	9	the	the	DT
cord-350992-l6l24pco	210	10	cellular	cellular	JJ
cord-350992-l6l24pco	210	11	and	and	CC
cord-350992-l6l24pco	210	12	systemic	systemic	JJ
cord-350992-l6l24pco	210	13	levels	level	NNS
cord-350992-l6l24pco	210	14	[	[	-LRB-
cord-350992-l6l24pco	210	15	2	2	CD
cord-350992-l6l24pco	210	16	-	-	SYM
cord-350992-l6l24pco	210	17	4	4	CD
cord-350992-l6l24pco	210	18	,	,	,
cord-350992-l6l24pco	210	19	95	95	CD
cord-350992-l6l24pco	210	20	,	,	,
cord-350992-l6l24pco	210	21	101	101	CD
cord-350992-l6l24pco	210	22	]	]	-RRB-
cord-350992-l6l24pco	210	23	.	.	.
cord-350992-l6l24pco	211	1	The	the	DT
cord-350992-l6l24pco	211	2	main	main	JJ
cord-350992-l6l24pco	211	3	systemic	systemic	JJ
cord-350992-l6l24pco	211	4	regulator	regulator	NN
cord-350992-l6l24pco	211	5	is	be	VBZ
cord-350992-l6l24pco	211	6	HAMP	HAMP	NNP
cord-350992-l6l24pco	211	7	.	.	.
cord-350992-l6l24pco	212	1	This	this	DT
cord-350992-l6l24pco	212	2	hormone	hormone	NN
cord-350992-l6l24pco	212	3	peptide	peptide	NN
cord-350992-l6l24pco	212	4	is	be	VBZ
cord-350992-l6l24pco	212	5	produced	produce	VBN
cord-350992-l6l24pco	212	6	mainly	mainly	RB
cord-350992-l6l24pco	212	7	in	in	IN
cord-350992-l6l24pco	212	8	the	the	DT
cord-350992-l6l24pco	212	9	liver	liver	NN
cord-350992-l6l24pco	212	10	and	and	CC
cord-350992-l6l24pco	212	11	is	be	VBZ
cord-350992-l6l24pco	212	12	regulated	regulate	VBN
cord-350992-l6l24pco	212	13	by	by	IN
cord-350992-l6l24pco	212	14	circulating	circulate	VBG
cord-350992-l6l24pco	212	15	and	and	CC
cord-350992-l6l24pco	212	16	tissue	tissue	NN
cord-350992-l6l24pco	212	17	iron	iron	NN
cord-350992-l6l24pco	212	18	levels	level	NNS
cord-350992-l6l24pco	212	19	through	through	IN
cord-350992-l6l24pco	212	20	the	the	DT
cord-350992-l6l24pco	212	21	bone	bone	NN
cord-350992-l6l24pco	212	22	J	J	NNP
cord-350992-l6l24pco	212	23	o	o	NN
cord-350992-l6l24pco	212	24	u	u	NN
cord-350992-l6l24pco	212	25	r	r	NN
cord-350992-l6l24pco	212	26	n	n	NN
cord-350992-l6l24pco	212	27	a	a	DT
cord-350992-l6l24pco	212	28	l	l	NN
cord-350992-l6l24pco	212	29	P	p	NN
cord-350992-l6l24pco	212	30	r	r	NN
cord-350992-l6l24pco	212	31	e	e	NN
cord-350992-l6l24pco	212	32	-p	-p	NN
cord-350992-l6l24pco	212	33	r	r	NN
cord-350992-l6l24pco	212	34	o	o	NN
cord-350992-l6l24pco	212	35	o	o	NN
cord-350992-l6l24pco	212	36	f	f	NN
cord-350992-l6l24pco	213	1	morphogenetic	morphogenetic	JJ
cord-350992-l6l24pco	213	2	/	/	SYM
cord-350992-l6l24pco	213	3	small	small	JJ
cord-350992-l6l24pco	213	4	mother	mother	NN
cord-350992-l6l24pco	213	5	against	against	IN
cord-350992-l6l24pco	213	6	decapentaplegic	decapentaplegic	NNP
cord-350992-l6l24pco	213	7	(	(	-LRB-
cord-350992-l6l24pco	213	8	BMP	BMP	NNP
cord-350992-l6l24pco	213	9	/	/	SYM
cord-350992-l6l24pco	213	10	SMAD	SMAD	NNP
cord-350992-l6l24pco	213	11	)	)	-RRB-
cord-350992-l6l24pco	213	12	pathway	pathway	VBP
cord-350992-l6l24pco	213	13	in	in	IN
cord-350992-l6l24pco	213	14	such	such	PDT
cord-350992-l6l24pco	213	15	a	a	DT
cord-350992-l6l24pco	213	16	way	way	NN
cord-350992-l6l24pco	213	17	that	that	WDT
cord-350992-l6l24pco	213	18	iron	iron	NN
cord-350992-l6l24pco	213	19	load	load	NN
cord-350992-l6l24pco	213	20	induces	induce	VBZ
cord-350992-l6l24pco	213	21	while	while	IN
cord-350992-l6l24pco	213	22	iron	iron	NN
cord-350992-l6l24pco	213	23	deficiency	deficiency	NN
cord-350992-l6l24pco	213	24	inhibits	inhibit	VBZ
cord-350992-l6l24pco	213	25	its	-PRON-	PRP$
cord-350992-l6l24pco	213	26	expression	expression	NN
cord-350992-l6l24pco	213	27	,	,	,
cord-350992-l6l24pco	213	28	mainly	mainly	RB
cord-350992-l6l24pco	213	29	acting	act	VBG
cord-350992-l6l24pco	213	30	on	on	IN
cord-350992-l6l24pco	213	31	intestinal	intestinal	JJ
cord-350992-l6l24pco	213	32	iron	iron	NN
cord-350992-l6l24pco	213	33	absorption	absorption	NN
cord-350992-l6l24pco	213	34	and	and	CC
cord-350992-l6l24pco	213	35	iron	iron	NN
cord-350992-l6l24pco	213	36	retention	retention	NN
cord-350992-l6l24pco	213	37	/	/	SYM
cord-350992-l6l24pco	213	38	release	release	NN
cord-350992-l6l24pco	213	39	by	by	IN
cord-350992-l6l24pco	213	40	macrophages	macrophage	NNS
cord-350992-l6l24pco	213	41	and	and	CC
cord-350992-l6l24pco	213	42	hepatocytes	hepatocyte	NNS
cord-350992-l6l24pco	213	43	.	.	.
cord-350992-l6l24pco	214	1	HAMP	HAMP	NNP
cord-350992-l6l24pco	214	2	expression	expression	NN
cord-350992-l6l24pco	214	3	is	be	VBZ
cord-350992-l6l24pco	214	4	also	also	RB
cord-350992-l6l24pco	214	5	downregulated	downregulate	VBN
cord-350992-l6l24pco	214	6	by	by	IN
cord-350992-l6l24pco	214	7	hypoxia	hypoxia	NN
cord-350992-l6l24pco	214	8	and	and	CC
cord-350992-l6l24pco	214	9	erythropoietin	erythropoietin	NN
cord-350992-l6l24pco	214	10	(	(	-LRB-
cord-350992-l6l24pco	214	11	EPO	EPO	NNP
cord-350992-l6l24pco	214	12	)	)	-RRB-
cord-350992-l6l24pco	214	13	through	through	IN
cord-350992-l6l24pco	214	14	erythroferrone	erythroferrone	NN
cord-350992-l6l24pco	214	15	(	(	-LRB-
cord-350992-l6l24pco	214	16	ERFE	ERFE	NNP
cord-350992-l6l24pco	214	17	)	)	-RRB-
cord-350992-l6l24pco	214	18	to	to	TO
cord-350992-l6l24pco	214	19	allow	allow	VB
cord-350992-l6l24pco	214	20	iron	iron	NN
cord-350992-l6l24pco	214	21	mobilization	mobilization	NN
cord-350992-l6l24pco	214	22	for	for	IN
cord-350992-l6l24pco	214	23	erythropoiesis	erythropoiesis	NN
cord-350992-l6l24pco	214	24	,	,	,
cord-350992-l6l24pco	214	25	while	while	IN
cord-350992-l6l24pco	214	26	it	-PRON-	PRP
cord-350992-l6l24pco	214	27	is	be	VBZ
cord-350992-l6l24pco	214	28	upregulated	upregulate	VBN
cord-350992-l6l24pco	214	29	by	by	IN
cord-350992-l6l24pco	214	30	inflammation	inflammation	NN
cord-350992-l6l24pco	214	31	.	.	.
cord-350992-l6l24pco	215	1	IL-6	IL-6	NNP
cord-350992-l6l24pco	215	2	is	be	VBZ
cord-350992-l6l24pco	215	3	the	the	DT
cord-350992-l6l24pco	215	4	main	main	JJ
cord-350992-l6l24pco	215	5	signal	signal	NN
cord-350992-l6l24pco	215	6	that	that	WDT
cord-350992-l6l24pco	215	7	induce	induce	VBP
cord-350992-l6l24pco	215	8	HAMP	HAMP	NNP
cord-350992-l6l24pco	215	9	during	during	IN
cord-350992-l6l24pco	215	10	inflammation	inflammation	NN
cord-350992-l6l24pco	215	11	,	,	,
cord-350992-l6l24pco	215	12	through	through	IN
cord-350992-l6l24pco	215	13	the	the	DT
cord-350992-l6l24pco	215	14	JAK	JAK	NNP
cord-350992-l6l24pco	215	15	/	/	SYM
cord-350992-l6l24pco	215	16	STAT3	STAT3	NNP
cord-350992-l6l24pco	215	17	pathway	pathway	NN
cord-350992-l6l24pco	215	18	in	in	IN
cord-350992-l6l24pco	215	19	association	association	NN
cord-350992-l6l24pco	215	20	with	with	IN
cord-350992-l6l24pco	215	21	the	the	DT
cord-350992-l6l24pco	215	22	BMP	BMP	NNP
cord-350992-l6l24pco	215	23	/	/	SYM
cord-350992-l6l24pco	215	24	SMAD	SMAD	NNP
cord-350992-l6l24pco	215	25	pathway	pathway	NN
cord-350992-l6l24pco	215	26	,	,	,
cord-350992-l6l24pco	215	27	but	but	CC
cord-350992-l6l24pco	215	28	also	also	RB
cord-350992-l6l24pco	215	29	IL-1	IL-1	NNP
cord-350992-l6l24pco	215	30	and	and	CC
cord-350992-l6l24pco	215	31	TNF-	TNF-	NNS
cord-350992-l6l24pco	215	32	have	have	VBP
cord-350992-l6l24pco	215	33	a	a	DT
cord-350992-l6l24pco	215	34	direct	direct	JJ
cord-350992-l6l24pco	215	35	role	role	NN
cord-350992-l6l24pco	215	36	on	on	IN
cord-350992-l6l24pco	215	37	HAMP	HAMP	NNP
cord-350992-l6l24pco	215	38	regulation	regulation	NN
cord-350992-l6l24pco	215	39	[	[	-LRB-
cord-350992-l6l24pco	215	40	95	95	CD
cord-350992-l6l24pco	215	41	,	,	,
cord-350992-l6l24pco	215	42	128	128	CD
cord-350992-l6l24pco	215	43	,	,	,
cord-350992-l6l24pco	215	44	129	129	CD
cord-350992-l6l24pco	215	45	]	]	-RRB-
cord-350992-l6l24pco	215	46	.	.	.
cord-350992-l6l24pco	216	1	As	as	IN
cord-350992-l6l24pco	216	2	stated	state	VBN
cord-350992-l6l24pco	216	3	above	above	RB
cord-350992-l6l24pco	216	4	,	,	,
cord-350992-l6l24pco	216	5	CQ	CQ	NNP
cord-350992-l6l24pco	216	6	/	/	SYM
cord-350992-l6l24pco	216	7	HCQ	HCQ	NNP
cord-350992-l6l24pco	216	8	not	not	RB
cord-350992-l6l24pco	216	9	only	only	RB
cord-350992-l6l24pco	216	10	interfere	interfere	VB
cord-350992-l6l24pco	216	11	with	with	IN
cord-350992-l6l24pco	216	12	cellular	cellular	JJ
cord-350992-l6l24pco	216	13	iron	iron	NN
cord-350992-l6l24pco	216	14	inducing	induce	VBG
cord-350992-l6l24pco	216	15	its	-PRON-	PRP$
cord-350992-l6l24pco	216	16	starvation	starvation	NN
cord-350992-l6l24pco	216	17	in	in	IN
cord-350992-l6l24pco	216	18	alveolar	alveolar	JJ
cord-350992-l6l24pco	216	19	macrophages	macrophage	NNS
cord-350992-l6l24pco	216	20	[	[	-LRB-
cord-350992-l6l24pco	216	21	122	122	CD
cord-350992-l6l24pco	216	22	,	,	,
cord-350992-l6l24pco	216	23	123	123	CD
cord-350992-l6l24pco	216	24	]	]	-RRB-
cord-350992-l6l24pco	216	25	,	,	,
cord-350992-l6l24pco	216	26	then	then	RB
cord-350992-l6l24pco	216	27	possibly	possibly	RB
cord-350992-l6l24pco	216	28	resulting	result	VBG
cord-350992-l6l24pco	216	29	in	in	IN
cord-350992-l6l24pco	216	30	a	a	DT
cord-350992-l6l24pco	216	31	switch	switch	NN
cord-350992-l6l24pco	216	32	to	to	IN
cord-350992-l6l24pco	216	33	M2	M2	NNP
cord-350992-l6l24pco	216	34	antiinflammatory	antiinflammatory	JJ
cord-350992-l6l24pco	216	35	state	state	NN
cord-350992-l6l24pco	216	36	,	,	,
cord-350992-l6l24pco	216	37	but	but	CC
cord-350992-l6l24pco	216	38	also	also	RB
cord-350992-l6l24pco	216	39	inhibit	inhibit	VB
cord-350992-l6l24pco	216	40	IL-6	IL-6	NNP
cord-350992-l6l24pco	216	41	,	,	,
cord-350992-l6l24pco	216	42	IL-1	IL-1	NNP
cord-350992-l6l24pco	216	43	and	and	CC
cord-350992-l6l24pco	216	44	TNF-	TNF-	NNP
cord-350992-l6l24pco	216	45	release	release	NN
cord-350992-l6l24pco	216	46	,	,	,
cord-350992-l6l24pco	216	47	possibly	possibly	RB
cord-350992-l6l24pco	216	48	reducing	reduce	VBG
cord-350992-l6l24pco	216	49	local	local	JJ
cord-350992-l6l24pco	216	50	HAMP	HAMP	NNP
cord-350992-l6l24pco	216	51	release	release	NN
cord-350992-l6l24pco	216	52	by	by	IN
cord-350992-l6l24pco	216	53	macrophages	macrophage	NNS
cord-350992-l6l24pco	216	54	.	.	.
cord-350992-l6l24pco	217	1	This	this	DT
cord-350992-l6l24pco	217	2	reduction	reduction	NN
cord-350992-l6l24pco	217	3	can	can	MD
cord-350992-l6l24pco	217	4	result	result	VB
cord-350992-l6l24pco	217	5	in	in	IN
cord-350992-l6l24pco	217	6	further	further	JJ
cord-350992-l6l24pco	217	7	decreased	decrease	VBN
cord-350992-l6l24pco	217	8	iron	iron	NN
cord-350992-l6l24pco	217	9	retention	retention	NN
cord-350992-l6l24pco	217	10	in	in	IN
cord-350992-l6l24pco	217	11	these	these	DT
cord-350992-l6l24pco	217	12	cells	cell	NNS
cord-350992-l6l24pco	217	13	allowing	allow	VBG
cord-350992-l6l24pco	217	14	direction	direction	NN
cord-350992-l6l24pco	217	15	towards	towards	IN
cord-350992-l6l24pco	217	16	inflammation	inflammation	NN
cord-350992-l6l24pco	217	17	resolution	resolution	NN
cord-350992-l6l24pco	217	18	.	.	.
cord-350992-l6l24pco	218	1	Further	further	RB
cord-350992-l6l24pco	218	2	,	,	,
cord-350992-l6l24pco	218	3	cytokine	cytokine	JJ
cord-350992-l6l24pco	218	4	decrease	decrease	NN
cord-350992-l6l24pco	218	5	could	could	MD
cord-350992-l6l24pco	218	6	result	result	VB
cord-350992-l6l24pco	218	7	in	in	IN
cord-350992-l6l24pco	218	8	systemic	systemic	JJ
cord-350992-l6l24pco	218	9	HAMP	HAMP	NNP
cord-350992-l6l24pco	218	10	decrease	decrease	VBP
cord-350992-l6l24pco	218	11	that	that	IN
cord-350992-l6l24pco	218	12	,	,	,
cord-350992-l6l24pco	218	13	through	through	IN
cord-350992-l6l24pco	218	14	increased	increase	VBN
cord-350992-l6l24pco	218	15	intestinal	intestinal	JJ
cord-350992-l6l24pco	218	16	iron	iron	NN
cord-350992-l6l24pco	218	17	absorption	absorption	NN
cord-350992-l6l24pco	218	18	,	,	,
cord-350992-l6l24pco	218	19	may	may	MD
cord-350992-l6l24pco	218	20	ameliorate	ameliorate	VB
cord-350992-l6l24pco	218	21	anemia	anemia	NN
cord-350992-l6l24pco	218	22	of	of	IN
cord-350992-l6l24pco	218	23	infection	infection	NN
cord-350992-l6l24pco	218	24	.	.	.
cord-350992-l6l24pco	219	1	Interestingly	interestingly	RB
cord-350992-l6l24pco	219	2	EPO	EPO	NNP
cord-350992-l6l24pco	219	3	treatment	treatment	NN
cord-350992-l6l24pco	219	4	has	have	VBZ
cord-350992-l6l24pco	219	5	recently	recently	RB
cord-350992-l6l24pco	219	6	been	be	VBN
cord-350992-l6l24pco	219	7	found	find	VBN
cord-350992-l6l24pco	219	8	to	to	TO
cord-350992-l6l24pco	219	9	attenuate	attenuate	VB
cord-350992-l6l24pco	219	10	COVID-19	covid-19	JJ
cord-350992-l6l24pco	219	11	severe	severe	JJ
cord-350992-l6l24pco	219	12	symptoms	symptom	NNS
cord-350992-l6l24pco	219	13	[	[	-LRB-
cord-350992-l6l24pco	219	14	130	130	CD
cord-350992-l6l24pco	219	15	]	]	-RRB-
cord-350992-l6l24pco	219	16	while	while	IN
cord-350992-l6l24pco	219	17	,	,	,
cord-350992-l6l24pco	219	18	through	through	IN
cord-350992-l6l24pco	219	19	in	in	IN
cord-350992-l6l24pco	219	20	silico	silico	NN
cord-350992-l6l24pco	219	21	modeling	modeling	NN
cord-350992-l6l24pco	219	22	,	,	,
cord-350992-l6l24pco	219	23	Sars	Sars	NNP
cord-350992-l6l24pco	219	24	-	-	HYPH
cord-350992-l6l24pco	219	25	Cov-2	Cov-2	NNP
cord-350992-l6l24pco	219	26	has	have	VBZ
cord-350992-l6l24pco	219	27	been	be	VBN
cord-350992-l6l24pco	219	28	found	find	VBN
cord-350992-l6l24pco	219	29	to	to	TO
cord-350992-l6l24pco	219	30	possibly	possibly	RB
cord-350992-l6l24pco	219	31	bind	bind	VB
cord-350992-l6l24pco	219	32	heme	heme	NN
cord-350992-l6l24pco	219	33	dissociating	dissociate	VBG
cord-350992-l6l24pco	219	34	iron	iron	NN
cord-350992-l6l24pco	219	35	from	from	IN
cord-350992-l6l24pco	219	36	porphyrin	porphyrin	NN
cord-350992-l6l24pco	219	37	[	[	-LRB-
cord-350992-l6l24pco	219	38	131	131	CD
cord-350992-l6l24pco	219	39	]	]	-RRB-
cord-350992-l6l24pco	219	40	.	.	.
cord-350992-l6l24pco	220	1	Numerous	numerous	JJ
cord-350992-l6l24pco	220	2	studies	study	NNS
cord-350992-l6l24pco	220	3	correlated	correlate	VBD
cord-350992-l6l24pco	220	4	thrombocytosis	thrombocytosis	NN
cord-350992-l6l24pco	220	5	induced	induce	VBN
cord-350992-l6l24pco	220	6	by	by	IN
cord-350992-l6l24pco	220	7	iron	iron	NN
cord-350992-l6l24pco	220	8	deficiency	deficiency	NN
cord-350992-l6l24pco	220	9	anemia	anemia	NN
cord-350992-l6l24pco	220	10	(	(	-LRB-
cord-350992-l6l24pco	220	11	IDA	IDA	NNP
cord-350992-l6l24pco	220	12	)	)	-RRB-
cord-350992-l6l24pco	220	13	with	with	IN
cord-350992-l6l24pco	220	14	thrombotic	thrombotic	JJ
cord-350992-l6l24pco	220	15	events	event	NNS
cord-350992-l6l24pco	220	16	[	[	-LRB-
cord-350992-l6l24pco	220	17	132	132	CD
cord-350992-l6l24pco	220	18	]	]	-RRB-
cord-350992-l6l24pco	220	19	[	[	-LRB-
cord-350992-l6l24pco	220	20	133	133	CD
cord-350992-l6l24pco	220	21	]	]	-RRB-
cord-350992-l6l24pco	220	22	[	[	-LRB-
cord-350992-l6l24pco	220	23	134	134	CD
cord-350992-l6l24pco	220	24	]	]	-RRB-
cord-350992-l6l24pco	220	25	[	[	-LRB-
cord-350992-l6l24pco	220	26	135	135	CD
cord-350992-l6l24pco	220	27	]	]	-RRB-
cord-350992-l6l24pco	220	28	.	.	.
cord-350992-l6l24pco	221	1	A	a	DT
cord-350992-l6l24pco	221	2	recent	recent	JJ
cord-350992-l6l24pco	221	3	study	study	NN
cord-350992-l6l24pco	221	4	has	have	VBZ
cord-350992-l6l24pco	221	5	evidenced	evidence	VBN
cord-350992-l6l24pco	221	6	that	that	IN
cord-350992-l6l24pco	221	7	IDA	IDA	NNP
cord-350992-l6l24pco	221	8	patients	patient	NNS
cord-350992-l6l24pco	221	9	manifesting	manifest	VBG
cord-350992-l6l24pco	221	10	thrombocytosis	thrombocytosis	NNP
cord-350992-l6l24pco	221	11	had	have	VBD
cord-350992-l6l24pco	221	12	2-fold	2-fold	DT
cord-350992-l6l24pco	221	13	augmented	augment	VBN
cord-350992-l6l24pco	221	14	risk	risk	NN
cord-350992-l6l24pco	221	15	of	of	IN
cord-350992-l6l24pco	221	16	thrombosis	thrombosis	NN
cord-350992-l6l24pco	221	17	when	when	WRB
cord-350992-l6l24pco	221	18	compared	compare	VBN
cord-350992-l6l24pco	221	19	with	with	IN
cord-350992-l6l24pco	221	20	IDA	IDA	NNP
cord-350992-l6l24pco	221	21	patient	patient	JJ
cord-350992-l6l24pco	221	22	with	with	IN
cord-350992-l6l24pco	221	23	normal	normal	JJ
cord-350992-l6l24pco	221	24	platelet	platelet	NN
cord-350992-l6l24pco	221	25	count	count	NN
cord-350992-l6l24pco	221	26	[	[	-LRB-
cord-350992-l6l24pco	221	27	136	136	CD
cord-350992-l6l24pco	221	28	]	]	-RRB-
cord-350992-l6l24pco	221	29	.	.	.
cord-350992-l6l24pco	222	1	Interestingly	interestingly	RB
cord-350992-l6l24pco	222	2	,	,	,
cord-350992-l6l24pco	222	3	COVID-19	covid-19	VBP
cord-350992-l6l24pco	222	4	patients	patient	NNS
cord-350992-l6l24pco	222	5	with	with	IN
cord-350992-l6l24pco	222	6	severe	severe	JJ
cord-350992-l6l24pco	222	7	pneumonia	pneumonia	NN
cord-350992-l6l24pco	222	8	seem	seem	VBP
cord-350992-l6l24pco	222	9	to	to	TO
cord-350992-l6l24pco	222	10	have	have	VB
cord-350992-l6l24pco	222	11	high	high	JJ
cord-350992-l6l24pco	222	12	platelet	platelet	NN
cord-350992-l6l24pco	222	13	counts	count	NNS
cord-350992-l6l24pco	222	14	compared	compare	VBN
cord-350992-l6l24pco	222	15	with	with	IN
cord-350992-l6l24pco	222	16	patients	patient	NNS
cord-350992-l6l24pco	222	17	with	with	IN
cord-350992-l6l24pco	222	18	severe	severe	JJ
cord-350992-l6l24pco	222	19	non	non	JJ
cord-350992-l6l24pco	222	20	-	-	JJ
cord-350992-l6l24pco	222	21	COVID-19	covid-19	JJ
cord-350992-l6l24pco	222	22	pneumonia	pneumonia	NN
cord-350992-l6l24pco	222	23	[	[	-LRB-
cord-350992-l6l24pco	222	24	137	137	CD
cord-350992-l6l24pco	222	25	]	]	-RRB-
cord-350992-l6l24pco	222	26	and	and	CC
cord-350992-l6l24pco	222	27	this	this	DT
cord-350992-l6l24pco	222	28	increase	increase	NN
cord-350992-l6l24pco	222	29	is	be	VBZ
cord-350992-l6l24pco	222	30	more	more	RBR
cord-350992-l6l24pco	222	31	evident	evident	JJ
cord-350992-l6l24pco	222	32	among	among	IN
cord-350992-l6l24pco	222	33	the	the	DT
cord-350992-l6l24pco	222	34	nonsurvivor	nonsurvivor	NN
cord-350992-l6l24pco	222	35	compared	compare	VBN
cord-350992-l6l24pco	222	36	with	with	IN
cord-350992-l6l24pco	222	37	survivor	survivor	NN
cord-350992-l6l24pco	222	38	COVID-19	covid-19	CD
cord-350992-l6l24pco	222	39	patients	patient	NNS
cord-350992-l6l24pco	222	40	[	[	-LRB-
cord-350992-l6l24pco	222	41	138	138	CD
cord-350992-l6l24pco	222	42	]	]	-RRB-
cord-350992-l6l24pco	222	43	.	.	.
cord-350992-l6l24pco	223	1	To	to	TO
cord-350992-l6l24pco	223	2	clarify	clarify	VB
cord-350992-l6l24pco	223	3	the	the	DT
cord-350992-l6l24pco	223	4	effect	effect	NN
cord-350992-l6l24pco	223	5	of	of	IN
cord-350992-l6l24pco	223	6	iron	iron	NN
cord-350992-l6l24pco	223	7	deficiency	deficiency	NN
cord-350992-l6l24pco	223	8	on	on	IN
cord-350992-l6l24pco	223	9	thrombotic	thrombotic	JJ
cord-350992-l6l24pco	223	10	propensity	propensity	NN
cord-350992-l6l24pco	223	11	in	in	IN
cord-350992-l6l24pco	223	12	animal	animal	NN
cord-350992-l6l24pco	223	13	models	model	NNS
cord-350992-l6l24pco	223	14	,	,	,
cord-350992-l6l24pco	223	15	thrombosis	thrombosis	NN
cord-350992-l6l24pco	223	16	was	be	VBD
cord-350992-l6l24pco	223	17	induced	induce	VBN
cord-350992-l6l24pco	223	18	in	in	IN
cord-350992-l6l24pco	223	19	Sprague	Sprague	NNP
cord-350992-l6l24pco	223	20	-	-	HYPH
cord-350992-l6l24pco	223	21	Dawley	Dawley	NNP
cord-350992-l6l24pco	223	22	rat	rat	NN
cord-350992-l6l24pco	223	23	fed	feed	VBN
cord-350992-l6l24pco	223	24	with	with	IN
cord-350992-l6l24pco	223	25	irondeficient	irondeficient	NN
cord-350992-l6l24pco	223	26	diet	diet	NN
cord-350992-l6l24pco	223	27	or	or	CC
cord-350992-l6l24pco	223	28	normal	normal	JJ
cord-350992-l6l24pco	223	29	diet	diet	NN
cord-350992-l6l24pco	223	30	as	as	IN
cord-350992-l6l24pco	223	31	control	control	NN
cord-350992-l6l24pco	223	32	.	.	.
cord-350992-l6l24pco	224	1	Iron	iron	NN
cord-350992-l6l24pco	224	2	deficiency	deficiency	NN
cord-350992-l6l24pco	224	3	induced	induce	VBD
cord-350992-l6l24pco	224	4	thrombocytosis	thrombocytosis	NNP
cord-350992-l6l24pco	224	5	and	and	CC
cord-350992-l6l24pco	224	6	platelet	platelet	NN
cord-350992-l6l24pco	224	7	number	number	NN
cord-350992-l6l24pco	224	8	resulted	result	VBD
cord-350992-l6l24pco	224	9	proportional	proportional	JJ
cord-350992-l6l24pco	224	10	with	with	IN
cord-350992-l6l24pco	224	11	thrombus	thrombus	NN
cord-350992-l6l24pco	224	12	size	size	NN
cord-350992-l6l24pco	224	13	.	.	.
cord-350992-l6l24pco	225	1	In	in	IN
cord-350992-l6l24pco	225	2	addition	addition	NN
cord-350992-l6l24pco	225	3	,	,	,
cord-350992-l6l24pco	225	4	platelet	platelet	NN
cord-350992-l6l24pco	225	5	adhesion	adhesion	NN
cord-350992-l6l24pco	225	6	and	and	CC
cord-350992-l6l24pco	225	7	aggregation	aggregation	NN
cord-350992-l6l24pco	225	8	were	be	VBD
cord-350992-l6l24pco	225	9	impaired	impair	VBN
cord-350992-l6l24pco	225	10	.	.	.
cord-350992-l6l24pco	226	1	Taking	take	VBG
cord-350992-l6l24pco	226	2	into	into	IN
cord-350992-l6l24pco	226	3	account	account	NN
cord-350992-l6l24pco	226	4	data	datum	NNS
cord-350992-l6l24pco	226	5	obtained	obtain	VBN
cord-350992-l6l24pco	226	6	in	in	IN
cord-350992-l6l24pco	226	7	this	this	DT
cord-350992-l6l24pco	226	8	model	model	NN
cord-350992-l6l24pco	226	9	,	,	,
cord-350992-l6l24pco	226	10	the	the	DT
cord-350992-l6l24pco	226	11	authors	author	NNS
cord-350992-l6l24pco	226	12	concluded	conclude	VBD
cord-350992-l6l24pco	226	13	that	that	IN
cord-350992-l6l24pco	226	14	anemia	anemia	NN
cord-350992-l6l24pco	226	15	of	of	IN
cord-350992-l6l24pco	226	16	inflammation	inflammation	NN
cord-350992-l6l24pco	226	17	,	,	,
cord-350992-l6l24pco	226	18	caused	cause	VBN
cord-350992-l6l24pco	226	19	by	by	IN
cord-350992-l6l24pco	226	20	HAMP	HAMP	NNP
cord-350992-l6l24pco	226	21	-	-	HYPH
cord-350992-l6l24pco	226	22	mediated	mediate	VBN
cord-350992-l6l24pco	226	23	iron	iron	NN
cord-350992-l6l24pco	226	24	sequestration	sequestration	NN
cord-350992-l6l24pco	226	25	in	in	IN
cord-350992-l6l24pco	226	26	the	the	DT
cord-350992-l6l24pco	226	27	liver	liver	NN
cord-350992-l6l24pco	226	28	,	,	,
cord-350992-l6l24pco	226	29	spleen	spleen	NN
cord-350992-l6l24pco	226	30	and	and	CC
cord-350992-l6l24pco	226	31	macrophages	macrophage	NNS
cord-350992-l6l24pco	226	32	,	,	,
cord-350992-l6l24pco	226	33	as	as	IN
cord-350992-l6l24pco	226	34	possibly	possibly	RB
cord-350992-l6l24pco	226	35	occurs	occur	VBZ
cord-350992-l6l24pco	226	36	in	in	IN
cord-350992-l6l24pco	226	37	COVID-19	covid-19	JJ
cord-350992-l6l24pco	226	38	patients	patient	NNS
cord-350992-l6l24pco	226	39	,	,	,
cord-350992-l6l24pco	226	40	may	may	MD
cord-350992-l6l24pco	226	41	be	be	VB
cord-350992-l6l24pco	226	42	considered	consider	VBN
cord-350992-l6l24pco	226	43	a	a	DT
cord-350992-l6l24pco	226	44	functional	functional	JJ
cord-350992-l6l24pco	226	45	iron	iron	NN
cord-350992-l6l24pco	226	46	deficiency	deficiency	NN
cord-350992-l6l24pco	226	47	(	(	-LRB-
cord-350992-l6l24pco	226	48	ID	ID	NNP
cord-350992-l6l24pco	226	49	)	)	-RRB-
cord-350992-l6l24pco	226	50	and	and	CC
cord-350992-l6l24pco	226	51	patients	patient	NNS
cord-350992-l6l24pco	226	52	affected	affect	VBN
cord-350992-l6l24pco	226	53	by	by	IN
cord-350992-l6l24pco	226	54	this	this	DT
cord-350992-l6l24pco	226	55	condition	condition	NN
cord-350992-l6l24pco	226	56	should	should	MD
cord-350992-l6l24pco	226	57	be	be	VB
cord-350992-l6l24pco	226	58	treated	treat	VBN
cord-350992-l6l24pco	226	59	as	as	IN
cord-350992-l6l24pco	226	60	patients	patient	NNS
cord-350992-l6l24pco	226	61	with	with	IN
cord-350992-l6l24pco	226	62	high	high	JJ
cord-350992-l6l24pco	226	63	risk	risk	NN
cord-350992-l6l24pco	226	64	of	of	IN
cord-350992-l6l24pco	226	65	thrombosis	thrombosis	NN
cord-350992-l6l24pco	226	66	[	[	-LRB-
cord-350992-l6l24pco	226	67	139	139	CD
cord-350992-l6l24pco	226	68	]	]	-RRB-
cord-350992-l6l24pco	226	69	.	.	.
cord-350992-l6l24pco	227	1	In	in	IN
cord-350992-l6l24pco	227	2	conclusion	conclusion	NN
cord-350992-l6l24pco	227	3	,	,	,
cord-350992-l6l24pco	227	4	the	the	DT
cord-350992-l6l24pco	227	5	multiple	multiple	JJ
cord-350992-l6l24pco	227	6	action	action	NN
cord-350992-l6l24pco	227	7	of	of	IN
cord-350992-l6l24pco	227	8	CQ	CQ	NNP
cord-350992-l6l24pco	227	9	and	and	CC
cord-350992-l6l24pco	227	10	HCQ	HCQ	NNP
cord-350992-l6l24pco	227	11	as	as	IN
cord-350992-l6l24pco	227	12	anti	anti	JJ
cord-350992-l6l24pco	227	13	-	-	JJ
cord-350992-l6l24pco	227	14	viral	viral	JJ
cord-350992-l6l24pco	227	15	,	,	,
cord-350992-l6l24pco	227	16	anti	anti	JJ
cord-350992-l6l24pco	227	17	-	-	JJ
cord-350992-l6l24pco	227	18	inflammatory	inflammatory	JJ
cord-350992-l6l24pco	227	19	and	and	CC
cord-350992-l6l24pco	227	20	anti	anti	JJ
cord-350992-l6l24pco	227	21	-	-	JJ
cord-350992-l6l24pco	227	22	thrombotic	thrombotic	JJ
cord-350992-l6l24pco	227	23	drug	drug	NN
cord-350992-l6l24pco	227	24	may	may	MD
cord-350992-l6l24pco	227	25	be	be	VB
cord-350992-l6l24pco	227	26	also	also	RB
cord-350992-l6l24pco	227	27	strictly	strictly	RB
cord-350992-l6l24pco	227	28	linked	link	VBN
cord-350992-l6l24pco	227	29	to	to	IN
cord-350992-l6l24pco	227	30	their	-PRON-	PRP$
cord-350992-l6l24pco	227	31	effects	effect	NNS
cord-350992-l6l24pco	227	32	on	on	IN
cord-350992-l6l24pco	227	33	iron	iron	NN
cord-350992-l6l24pco	227	34	homeostasis	homeostasis	NN
cord-350992-l6l24pco	227	35	,	,	,
cord-350992-l6l24pco	227	36	both	both	CC
cord-350992-l6l24pco	227	37	at	at	IN
cord-350992-l6l24pco	227	38	the	the	DT
cord-350992-l6l24pco	227	39	local	local	JJ
cord-350992-l6l24pco	227	40	and	and	CC
cord-350992-l6l24pco	227	41	systemic	systemic	JJ
cord-350992-l6l24pco	227	42	level	level	NN
cord-350992-l6l24pco	227	43	.	.	.
cord-350992-l6l24pco	228	1	Interestingly	interestingly	RB
cord-350992-l6l24pco	228	2	,	,	,
cord-350992-l6l24pco	228	3	another	another	DT
cord-350992-l6l24pco	228	4	common	common	JJ
cord-350992-l6l24pco	228	5	drug	drug	NN
cord-350992-l6l24pco	228	6	,	,	,
cord-350992-l6l24pco	228	7	frequently	frequently	RB
cord-350992-l6l24pco	228	8	used	use	VBN
cord-350992-l6l24pco	228	9	in	in	IN
cord-350992-l6l24pco	228	10	the	the	DT
cord-350992-l6l24pco	228	11	treatment	treatment	NN
cord-350992-l6l24pco	228	12	of	of	IN
cord-350992-l6l24pco	228	13	COVID-19	covid-19	JJ
cord-350992-l6l24pco	228	14	patients	patient	NNS
cord-350992-l6l24pco	228	15	with	with	IN
cord-350992-l6l24pco	228	16	markedly	markedly	RB
cord-350992-l6l24pco	228	17	J	J	NNP
cord-350992-l6l24pco	228	18	o	o	NN
cord-350992-l6l24pco	228	19	u	u	NN
cord-350992-l6l24pco	228	20	r	r	NN
cord-350992-l6l24pco	228	21	n	n	NN
cord-350992-l6l24pco	228	22	a	a	DT
cord-350992-l6l24pco	228	23	l	l	NN
cord-350992-l6l24pco	228	24	P	p	NN
cord-350992-l6l24pco	228	25	r	r	NN
cord-350992-l6l24pco	228	26	e	e	NN
cord-350992-l6l24pco	228	27	-p	-p	NN
cord-350992-l6l24pco	228	28	r	r	NN
cord-350992-l6l24pco	228	29	o	o	NN
cord-350992-l6l24pco	228	30	o	o	NN
cord-350992-l6l24pco	228	31	f	f	NN
cord-350992-l6l24pco	228	32	elevated	elevated	JJ
cord-350992-l6l24pco	228	33	D	d	NN
cord-350992-l6l24pco	228	34	-	-	HYPH
cord-350992-l6l24pco	228	35	dimer	dimer	NN
cord-350992-l6l24pco	228	36	levels	level	NNS
cord-350992-l6l24pco	228	37	is	be	VBZ
cord-350992-l6l24pco	228	38	heparin	heparin	JJ
cord-350992-l6l24pco	228	39	.	.	.
cord-350992-l6l24pco	229	1	Like	like	IN
cord-350992-l6l24pco	229	2	CQ	CQ	NNP
cord-350992-l6l24pco	229	3	and	and	CC
cord-350992-l6l24pco	229	4	HCQ	HCQ	NNP
cord-350992-l6l24pco	229	5	,	,	,
cord-350992-l6l24pco	229	6	heparin	heparin	NN
cord-350992-l6l24pco	229	7	is	be	VBZ
cord-350992-l6l24pco	229	8	a	a	DT
cord-350992-l6l24pco	229	9	versatile	versatile	JJ
cord-350992-l6l24pco	229	10	drug	drug	NN
cord-350992-l6l24pco	229	11	,	,	,
cord-350992-l6l24pco	229	12	as	as	IN
cord-350992-l6l24pco	229	13	defined	define	VBN
cord-350992-l6l24pco	229	14	by	by	IN
cord-350992-l6l24pco	229	15	Jecko	Jecko	NNP
cord-350992-l6l24pco	229	16	Thachil	Thachil	NNP
cord-350992-l6l24pco	229	17	[	[	-LRB-
cord-350992-l6l24pco	229	18	35	35	CD
cord-350992-l6l24pco	229	19	]	]	-RRB-
cord-350992-l6l24pco	229	20	,	,	,
cord-350992-l6l24pco	229	21	due	due	IN
cord-350992-l6l24pco	229	22	to	to	IN
cord-350992-l6l24pco	229	23	its	-PRON-	PRP$
cord-350992-l6l24pco	229	24	possible	possible	JJ
cord-350992-l6l24pco	229	25	actions	action	NNS
cord-350992-l6l24pco	229	26	as	as	IN
cord-350992-l6l24pco	229	27	anti	anti	JJ
cord-350992-l6l24pco	229	28	-	-	JJ
cord-350992-l6l24pco	229	29	coagulant	coagulant	JJ
cord-350992-l6l24pco	229	30	,	,	,
cord-350992-l6l24pco	229	31	anti	anti	JJ
cord-350992-l6l24pco	229	32	-	-	JJ
cord-350992-l6l24pco	229	33	inflammatory	inflammatory	JJ
cord-350992-l6l24pco	229	34	and	and	CC
cord-350992-l6l24pco	229	35	anti	anti	JJ
cord-350992-l6l24pco	229	36	-	-	JJ
cord-350992-l6l24pco	229	37	viral	viral	JJ
cord-350992-l6l24pco	229	38	drug	drug	NN
cord-350992-l6l24pco	229	39	.	.	.
cord-350992-l6l24pco	230	1	It	-PRON-	PRP
cord-350992-l6l24pco	230	2	is	be	VBZ
cord-350992-l6l24pco	230	3	interesting	interesting	JJ
cord-350992-l6l24pco	230	4	to	to	TO
cord-350992-l6l24pco	230	5	note	note	VB
cord-350992-l6l24pco	230	6	that	that	IN
cord-350992-l6l24pco	230	7	,	,	,
cord-350992-l6l24pco	230	8	like	like	IN
cord-350992-l6l24pco	230	9	CQ	CQ	NNP
cord-350992-l6l24pco	230	10	/	/	SYM
cord-350992-l6l24pco	230	11	HCQ	HCQ	NNP
cord-350992-l6l24pco	230	12	,	,	,
cord-350992-l6l24pco	230	13	heparin	heparin	JJ
cord-350992-l6l24pco	230	14	too	too	RB
cord-350992-l6l24pco	230	15	has	have	VBZ
cord-350992-l6l24pco	230	16	been	be	VBN
cord-350992-l6l24pco	230	17	demonstrated	demonstrate	VBN
cord-350992-l6l24pco	230	18	to	to	TO
cord-350992-l6l24pco	230	19	modulate	modulate	VB
cord-350992-l6l24pco	230	20	iron	iron	NN
cord-350992-l6l24pco	230	21	metabolism	metabolism	NN
cord-350992-l6l24pco	230	22	:	:	:
cord-350992-l6l24pco	230	23	this	this	DT
cord-350992-l6l24pco	230	24	antithrombotic	antithrombotic	JJ
cord-350992-l6l24pco	230	25	drug	drug	NN
cord-350992-l6l24pco	230	26	has	have	VBZ
cord-350992-l6l24pco	230	27	indeed	indeed	RB
cord-350992-l6l24pco	230	28	been	be	VBN
cord-350992-l6l24pco	230	29	demonstrated	demonstrate	VBN
cord-350992-l6l24pco	230	30	to	to	TO
cord-350992-l6l24pco	230	31	inhibit	inhibit	VB
cord-350992-l6l24pco	230	32	HAMP	HAMP	NNP
cord-350992-l6l24pco	230	33	expression	expression	NN
cord-350992-l6l24pco	230	34	in	in	IN
cord-350992-l6l24pco	230	35	human	human	JJ
cord-350992-l6l24pco	230	36	macrophages	macrophage	NNS
cord-350992-l6l24pco	230	37	,	,	,
cord-350992-l6l24pco	230	38	to	to	TO
cord-350992-l6l24pco	230	39	increase	increase	VB
cord-350992-l6l24pco	230	40	FPN1	fpn1	JJ
cord-350992-l6l24pco	230	41	plasma	plasma	NN
cord-350992-l6l24pco	230	42	-	-	HYPH
cord-350992-l6l24pco	230	43	membrane	membrane	NN
cord-350992-l6l24pco	230	44	expression	expression	NN
cord-350992-l6l24pco	230	45	and	and	CC
cord-350992-l6l24pco	230	46	promote	promote	VB
cord-350992-l6l24pco	230	47	iron	iron	NN
cord-350992-l6l24pco	230	48	export	export	NN
cord-350992-l6l24pco	230	49	,	,	,
cord-350992-l6l24pco	230	50	resulting	result	VBG
cord-350992-l6l24pco	230	51	in	in	IN
cord-350992-l6l24pco	230	52	cellular	cellular	JJ
cord-350992-l6l24pco	230	53	iron	iron	NN
cord-350992-l6l24pco	230	54	starvation	starvation	NN
cord-350992-l6l24pco	230	55	[	[	-LRB-
cord-350992-l6l24pco	230	56	140	140	CD
cord-350992-l6l24pco	230	57	]	]	-RRB-
cord-350992-l6l24pco	230	58	.	.	.
cord-350992-l6l24pco	231	1	All	all	PDT
cord-350992-l6l24pco	231	2	this	this	DT
cord-350992-l6l24pco	231	3	evidence	evidence	NN
cord-350992-l6l24pco	231	4	suggest	suggest	VBP
cord-350992-l6l24pco	231	5	a	a	DT
cord-350992-l6l24pco	231	6	possible	possible	JJ
cord-350992-l6l24pco	231	7	role	role	NN
cord-350992-l6l24pco	231	8	of	of	IN
cord-350992-l6l24pco	231	9	iron	iron	NN
cord-350992-l6l24pco	231	10	in	in	IN
cord-350992-l6l24pco	231	11	Sars	Sars	NNP
cord-350992-l6l24pco	231	12	-	-	HYPH
cord-350992-l6l24pco	231	13	Cov-2	Cov-2	NNP
cord-350992-l6l24pco	231	14	infection	infection	NN
cord-350992-l6l24pco	231	15	that	that	WDT
cord-350992-l6l24pco	231	16	would	would	MD
cord-350992-l6l24pco	231	17	be	be	VB
cord-350992-l6l24pco	231	18	explored	explore	VBN
cord-350992-l6l24pco	231	19	in	in	IN
cord-350992-l6l24pco	231	20	future	future	JJ
cord-350992-l6l24pco	231	21	basic	basic	JJ
cord-350992-l6l24pco	231	22	and	and	CC
cord-350992-l6l24pco	231	23	clinical	clinical	JJ
cord-350992-l6l24pco	231	24	research	research	NN
cord-350992-l6l24pco	231	25	,	,	,
cord-350992-l6l24pco	231	26	also	also	RB
cord-350992-l6l24pco	231	27	considering	consider	VBG
cord-350992-l6l24pco	231	28	it	-PRON-	PRP
cord-350992-l6l24pco	231	29	as	as	IN
cord-350992-l6l24pco	231	30	a	a	DT
cord-350992-l6l24pco	231	31	potential	potential	JJ
cord-350992-l6l24pco	231	32	target	target	NN
cord-350992-l6l24pco	231	33	for	for	IN
cord-350992-l6l24pco	231	34	COVID-19	COVID-19	NNP
cord-350992-l6l24pco	231	35	therapy	therapy	NN
cord-350992-l6l24pco	231	36	as	as	IN
cord-350992-l6l24pco	231	37	proposed	propose	VBN
cord-350992-l6l24pco	231	38	for	for	IN
cord-350992-l6l24pco	231	39	other	other	JJ
cord-350992-l6l24pco	231	40	human	human	JJ
cord-350992-l6l24pco	231	41	infectious	infectious	JJ
cord-350992-l6l24pco	231	42	diseases	disease	NNS
cord-350992-l6l24pco	231	43	[	[	-LRB-
cord-350992-l6l24pco	231	44	2	2	CD
cord-350992-l6l24pco	231	45	]	]	-RRB-
cord-350992-l6l24pco	231	46	[	[	-LRB-
cord-350992-l6l24pco	231	47	3	3	CD
cord-350992-l6l24pco	231	48	]	]	-RRB-
cord-350992-l6l24pco	231	49	[	[	-LRB-
cord-350992-l6l24pco	231	50	4	4	CD
cord-350992-l6l24pco	231	51	]	]	-RRB-
cord-350992-l6l24pco	231	52	.	.	.
cord-350992-l6l24pco	232	1	Molecular	molecular	JJ
cord-350992-l6l24pco	232	2	mechanism	mechanism	NN
cord-350992-l6l24pco	232	3	and	and	CC
cord-350992-l6l24pco	232	4	theoretical	theoretical	JJ
cord-350992-l6l24pco	232	5	mode	mode	NN
cord-350992-l6l24pco	232	6	of	of	IN
cord-350992-l6l24pco	232	7	action	action	NN
cord-350992-l6l24pco	232	8	of	of	IN
cord-350992-l6l24pco	232	9	CQ	CQ	NNP
cord-350992-l6l24pco	232	10	and	and	CC
cord-350992-l6l24pco	232	11	HCQ	HCQ	NNP
cord-350992-l6l24pco	232	12	on	on	IN
cord-350992-l6l24pco	232	13	multiple	multiple	JJ
cord-350992-l6l24pco	232	14	steps	step	NNS
cord-350992-l6l24pco	232	15	of	of	IN
cord-350992-l6l24pco	232	16	the	the	DT
cord-350992-l6l24pco	232	17	viral	viral	JJ
cord-350992-l6l24pco	232	18	pathway	pathway	NN
cord-350992-l6l24pco	232	19	and	and	CC
cord-350992-l6l24pco	232	20	the	the	DT
cord-350992-l6l24pco	232	21	demonstrated	demonstrate	VBN
cord-350992-l6l24pco	232	22	in	in	IN
cord-350992-l6l24pco	232	23	vitro	vitro	FW
cord-350992-l6l24pco	232	24	activity	activity	NN
cord-350992-l6l24pco	232	25	against	against	IN
cord-350992-l6l24pco	232	26	COVID-19	COVID-19	NNP
cord-350992-l6l24pco	232	27	[	[	-LRB-
cord-350992-l6l24pco	232	28	8	8	CD
cord-350992-l6l24pco	232	29	]	]	-RRB-
cord-350992-l6l24pco	233	1	[	[	-LRB-
cord-350992-l6l24pco	233	2	9	9	CD
cord-350992-l6l24pco	233	3	]	]	-RRB-
cord-350992-l6l24pco	233	4	[	[	-LRB-
cord-350992-l6l24pco	233	5	10	10	CD
cord-350992-l6l24pco	233	6	]	]	-RRB-
cord-350992-l6l24pco	233	7	have	have	VBP
cord-350992-l6l24pco	233	8	prompted	prompt	VBN
cord-350992-l6l24pco	233	9	their	-PRON-	PRP$
cord-350992-l6l24pco	233	10	off	off	JJ
cord-350992-l6l24pco	233	11	-	-	HYPH
cord-350992-l6l24pco	233	12	label	label	NN
cord-350992-l6l24pco	233	13	use	use	NN
cord-350992-l6l24pco	233	14	in	in	IN
cord-350992-l6l24pco	233	15	clinical	clinical	JJ
cord-350992-l6l24pco	233	16	setting	setting	NN
cord-350992-l6l24pco	233	17	during	during	IN
cord-350992-l6l24pco	233	18	this	this	DT
cord-350992-l6l24pco	233	19	pandemic	pandemic	NN
cord-350992-l6l24pco	233	20	emergency	emergency	NN
cord-350992-l6l24pco	233	21	.	.	.
cord-350992-l6l24pco	234	1	Several	several	JJ
cord-350992-l6l24pco	234	2	clinical	clinical	JJ
cord-350992-l6l24pco	234	3	trials	trial	NNS
cord-350992-l6l24pco	234	4	have	have	VBP
cord-350992-l6l24pco	234	5	been	be	VBN
cord-350992-l6l24pco	234	6	launched	launch	VBN
cord-350992-l6l24pco	234	7	to	to	TO
cord-350992-l6l24pco	234	8	evaluate	evaluate	VB
cord-350992-l6l24pco	234	9	the	the	DT
cord-350992-l6l24pco	234	10	effectiveness	effectiveness	NN
cord-350992-l6l24pco	234	11	of	of	IN
cord-350992-l6l24pco	234	12	these	these	DT
cord-350992-l6l24pco	234	13	drugs	drug	NNS
cord-350992-l6l24pco	234	14	[	[	-LRB-
cord-350992-l6l24pco	234	15	141	141	CD
cord-350992-l6l24pco	234	16	,	,	,
cord-350992-l6l24pco	234	17	142	142	CD
cord-350992-l6l24pco	234	18	]	]	-RRB-
cord-350992-l6l24pco	234	19	.	.	.
cord-350992-l6l24pco	235	1	Until	until	IN
cord-350992-l6l24pco	235	2	now	now	RB
cord-350992-l6l24pco	235	3	,	,	,
cord-350992-l6l24pco	235	4	published	publish	VBN
cord-350992-l6l24pco	235	5	clinical	clinical	JJ
cord-350992-l6l24pco	235	6	data	datum	NNS
cord-350992-l6l24pco	235	7	on	on	IN
cord-350992-l6l24pco	235	8	CQ	CQ	NNP
cord-350992-l6l24pco	235	9	and	and	CC
cord-350992-l6l24pco	235	10	HCQ	HCQ	NNP
cord-350992-l6l24pco	235	11	are	be	VBP
cord-350992-l6l24pco	235	12	limited	limited	JJ
cord-350992-l6l24pco	235	13	and	and	CC
cord-350992-l6l24pco	235	14	regard	regard	VBP
cord-350992-l6l24pco	235	15	only	only	RB
cord-350992-l6l24pco	235	16	small	small	JJ
cord-350992-l6l24pco	235	17	,	,	,
cord-350992-l6l24pco	235	18	poorly	poorly	RB
cord-350992-l6l24pco	235	19	controlled	control	VBN
cord-350992-l6l24pco	235	20	or	or	CC
cord-350992-l6l24pco	235	21	uncontrolled	uncontrolled	JJ
cord-350992-l6l24pco	235	22	clinical	clinical	JJ
cord-350992-l6l24pco	235	23	studies	study	NNS
cord-350992-l6l24pco	235	24	.	.	.
cord-350992-l6l24pco	236	1	We	-PRON-	PRP
cord-350992-l6l24pco	236	2	found	find	VBD
cord-350992-l6l24pco	236	3	only	only	RB
cord-350992-l6l24pco	236	4	four	four	CD
cord-350992-l6l24pco	236	5	published	publish	VBN
cord-350992-l6l24pco	236	6	reports	report	NNS
cord-350992-l6l24pco	236	7	of	of	IN
cord-350992-l6l24pco	236	8	these	these	DT
cord-350992-l6l24pco	236	9	trials	trial	NNS
cord-350992-l6l24pco	236	10	in	in	IN
cord-350992-l6l24pco	236	11	PubMed	PubMed	NNP
cord-350992-l6l24pco	236	12	till	till	IN
cord-350992-l6l24pco	236	13	April	April	NNP
cord-350992-l6l24pco	236	14	20th	20th	NN
cord-350992-l6l24pco	236	15	,	,	,
cord-350992-l6l24pco	236	16	2020	2020	CD
cord-350992-l6l24pco	236	17	.	.	.
cord-350992-l6l24pco	237	1	The	the	DT
cord-350992-l6l24pco	237	2	first	first	JJ
cord-350992-l6l24pco	237	3	clinical	clinical	JJ
cord-350992-l6l24pco	237	4	study	study	NN
cord-350992-l6l24pco	237	5	to	to	TO
cord-350992-l6l24pco	237	6	evaluate	evaluate	VB
cord-350992-l6l24pco	237	7	the	the	DT
cord-350992-l6l24pco	237	8	efficacy	efficacy	NN
cord-350992-l6l24pco	237	9	and	and	CC
cord-350992-l6l24pco	237	10	safety	safety	NN
cord-350992-l6l24pco	237	11	of	of	IN
cord-350992-l6l24pco	237	12	CQ	CQ	NNP
cord-350992-l6l24pco	237	13	/	/	SYM
cord-350992-l6l24pco	237	14	HCQ	HCQ	NNP
cord-350992-l6l24pco	237	15	in	in	IN
cord-350992-l6l24pco	237	16	patients	patient	NNS
cord-350992-l6l24pco	237	17	with	with	IN
cord-350992-l6l24pco	237	18	COVID-19	COVID-19	NNP
cord-350992-l6l24pco	237	19	has	have	VBZ
cord-350992-l6l24pco	237	20	been	be	VBN
cord-350992-l6l24pco	237	21	reported	report	VBN
cord-350992-l6l24pco	237	22	by	by	IN
cord-350992-l6l24pco	237	23	Huang	Huang	NNP
cord-350992-l6l24pco	237	24	and	and	CC
cord-350992-l6l24pco	237	25	colleagues	colleague	NNS
cord-350992-l6l24pco	237	26	[	[	-LRB-
cord-350992-l6l24pco	237	27	143	143	CD
cord-350992-l6l24pco	237	28	]	]	-RRB-
cord-350992-l6l24pco	237	29	from	from	IN
cord-350992-l6l24pco	237	30	China	China	NNP
cord-350992-l6l24pco	237	31	.	.	.
cord-350992-l6l24pco	238	1	The	the	DT
cord-350992-l6l24pco	238	2	authors	author	NNS
cord-350992-l6l24pco	238	3	screened	screen	VBD
cord-350992-l6l24pco	238	4	22	22	CD
cord-350992-l6l24pco	238	5	patients	patient	NNS
cord-350992-l6l24pco	238	6	tested	test	VBN
cord-350992-l6l24pco	238	7	positive	positive	JJ
cord-350992-l6l24pco	238	8	for	for	IN
cord-350992-l6l24pco	238	9	12,5	12,5	CD
cord-350992-l6l24pco	238	10	%	%	NN
cord-350992-l6l24pco	238	11	of	of	IN
cord-350992-l6l24pco	238	12	controls	control	NNS
cord-350992-l6l24pco	238	13	.	.	.
cord-350992-l6l24pco	239	1	Treatment	treatment	NN
cord-350992-l6l24pco	239	2	was	be	VBD
cord-350992-l6l24pco	239	3	more	more	RBR
cord-350992-l6l24pco	239	4	effective	effective	JJ
cord-350992-l6l24pco	239	5	in	in	IN
cord-350992-l6l24pco	239	6	patients	patient	NNS
cord-350992-l6l24pco	239	7	with	with	IN
cord-350992-l6l24pco	239	8	symptoms	symptom	NNS
cord-350992-l6l24pco	239	9	than	than	IN
cord-350992-l6l24pco	239	10	in	in	IN
cord-350992-l6l24pco	239	11	asymptomatic	asymptomatic	JJ
cord-350992-l6l24pco	239	12	patients	patient	NNS
cord-350992-l6l24pco	239	13	.	.	.
cord-350992-l6l24pco	240	1	The	the	DT
cord-350992-l6l24pco	240	2	same	same	JJ
cord-350992-l6l24pco	240	3	researchers	researcher	NNS
cord-350992-l6l24pco	240	4	[	[	-LRB-
cord-350992-l6l24pco	240	5	145	145	CD
cord-350992-l6l24pco	240	6	]	]	-RRB-
cord-350992-l6l24pco	240	7	further	further	RB
cord-350992-l6l24pco	240	8	conducted	conduct	VBD
cord-350992-l6l24pco	240	9	an	an	DT
cord-350992-l6l24pco	240	10	uncontrolled	uncontrolled	JJ
cord-350992-l6l24pco	240	11	non	non	JJ
cord-350992-l6l24pco	240	12	-	-	JJ
cord-350992-l6l24pco	240	13	comparative	comparative	JJ
cord-350992-l6l24pco	240	14	observational	observational	JJ
cord-350992-l6l24pco	240	15	study	study	NN
cord-350992-l6l24pco	240	16	with	with	IN
cord-350992-l6l24pco	240	17	80	80	CD
cord-350992-l6l24pco	240	18	enrolled	enrol	VBN
cord-350992-l6l24pco	240	19	patients	patient	NNS
cord-350992-l6l24pco	240	20	and	and	CC
cord-350992-l6l24pco	240	21	the	the	DT
cord-350992-l6l24pco	240	22	same	same	JJ
cord-350992-l6l24pco	240	23	treatment	treatment	NN
cord-350992-l6l24pco	240	24	protocol	protocol	NN
cord-350992-l6l24pco	240	25	for	for	IN
cord-350992-l6l24pco	240	26	a	a	DT
cord-350992-l6l24pco	240	27	maximum	maximum	NN
cord-350992-l6l24pco	240	28	of	of	IN
cord-350992-l6l24pco	240	29	10	10	CD
cord-350992-l6l24pco	240	30	days	day	NNS
cord-350992-l6l24pco	240	31	.	.	.
cord-350992-l6l24pco	241	1	Six	six	CD
cord-350992-l6l24pco	241	2	of	of	IN
cord-350992-l6l24pco	241	3	these	these	DT
cord-350992-l6l24pco	241	4	patients	patient	NNS
cord-350992-l6l24pco	241	5	were	be	VBD
cord-350992-l6l24pco	241	6	from	from	IN
cord-350992-l6l24pco	241	7	the	the	DT
cord-350992-l6l24pco	241	8	previous	previous	JJ
cord-350992-l6l24pco	241	9	study	study	NN
cord-350992-l6l24pco	241	10	.	.	.
cord-350992-l6l24pco	242	1	Most	Most	JJS
cord-350992-l6l24pco	242	2	patients	patient	NNS
cord-350992-l6l24pco	242	3	(	(	-LRB-
cord-350992-l6l24pco	242	4	65	65	CD
cord-350992-l6l24pco	242	5	,	,	,
cord-350992-l6l24pco	242	6	81,3	81,3	CD
cord-350992-l6l24pco	242	7	%	%	NN
cord-350992-l6l24pco	242	8	)	)	-RRB-
cord-350992-l6l24pco	242	9	were	be	VBD
cord-350992-l6l24pco	242	10	discharged	discharge	VBN
cord-350992-l6l24pco	242	11	from	from	IN
cord-350992-l6l24pco	242	12	the	the	DT
cord-350992-l6l24pco	242	13	infectious	infectious	JJ
cord-350992-l6l24pco	242	14	disease	disease	NN
cord-350992-l6l24pco	242	15	unit	unit	NN
cord-350992-l6l24pco	242	16	(	(	-LRB-
cord-350992-l6l24pco	242	17	IDU	IDU	NNP
cord-350992-l6l24pco	242	18	)	)	-RRB-
cord-350992-l6l24pco	242	19	with	with	IN
cord-350992-l6l24pco	242	20	a	a	DT
cord-350992-l6l24pco	242	21	mean	mean	JJ
cord-350992-l6l24pco	242	22	length	length	NN
cord-350992-l6l24pco	242	23	stay	stay	NN
cord-350992-l6l24pco	242	24	of	of	IN
cord-350992-l6l24pco	242	25	4.6	4.6	CD
cord-350992-l6l24pco	242	26	days	day	NNS
cord-350992-l6l24pco	242	27	,	,	,
cord-350992-l6l24pco	242	28	while	while	IN
cord-350992-l6l24pco	242	29	13	13	CD
cord-350992-l6l24pco	242	30	were	be	VBD
cord-350992-l6l24pco	242	31	still	still	RB
cord-350992-l6l24pco	242	32	hospitalized	hospitalize	VBN
cord-350992-l6l24pco	242	33	,	,	,
cord-350992-l6l24pco	242	34	1	1	CD
cord-350992-l6l24pco	242	35	died	die	VBD
cord-350992-l6l24pco	242	36	and	and	CC
cord-350992-l6l24pco	242	37	1	1	CD
cord-350992-l6l24pco	242	38	stopped	stop	VBD
cord-350992-l6l24pco	242	39	treatment	treatment	NN
cord-350992-l6l24pco	242	40	for	for	IN
cord-350992-l6l24pco	242	41	the	the	DT
cord-350992-l6l24pco	242	42	potential	potential	JJ
cord-350992-l6l24pco	242	43	interaction	interaction	NN
cord-350992-l6l24pco	242	44	with	with	IN
cord-350992-l6l24pco	242	45	other	other	JJ
cord-350992-l6l24pco	242	46	drugs	drug	NNS
cord-350992-l6l24pco	242	47	.	.	.
cord-350992-l6l24pco	243	1	On	on	IN
cord-350992-l6l24pco	243	2	the	the	DT
cord-350992-l6l24pco	243	3	total	total	NN
cord-350992-l6l24pco	243	4	,	,	,
cord-350992-l6l24pco	243	5	15	15	CD
cord-350992-l6l24pco	243	6	%	%	NN
cord-350992-l6l24pco	243	7	required	require	VBD
cord-350992-l6l24pco	243	8	oxygen	oxygen	NN
cord-350992-l6l24pco	243	9	therapy	therapy	NN
cord-350992-l6l24pco	243	10	,	,	,
cord-350992-l6l24pco	243	11	3	3	CD
cord-350992-l6l24pco	243	12	were	be	VBD
cord-350992-l6l24pco	243	13	transferred	transfer	VBN
cord-350992-l6l24pco	243	14	in	in	IN
cord-350992-l6l24pco	243	15	ICU	ICU	NNP
cord-350992-l6l24pco	243	16	and	and	CC
cord-350992-l6l24pco	243	17	two	two	CD
cord-350992-l6l24pco	243	18	of	of	IN
cord-350992-l6l24pco	243	19	them	-PRON-	PRP
cord-350992-l6l24pco	243	20	improved	improve	VBD
cord-350992-l6l24pco	243	21	and	and	CC
cord-350992-l6l24pco	243	22	returned	return	VBD
cord-350992-l6l24pco	243	23	to	to	IN
cord-350992-l6l24pco	243	24	IDU	IDU	NNP
cord-350992-l6l24pco	243	25	,	,	,
cord-350992-l6l24pco	243	26	the	the	DT
cord-350992-l6l24pco	243	27	third	third	JJ
cord-350992-l6l24pco	243	28	remained	remain	VBD
cord-350992-l6l24pco	243	29	in	in	IN
cord-350992-l6l24pco	243	30	ICU	ICU	NNP
cord-350992-l6l24pco	243	31	.	.	.
cord-350992-l6l24pco	244	1	Overall	overall	RB
cord-350992-l6l24pco	244	2	,	,	,
cord-350992-l6l24pco	244	3	for	for	IN
cord-350992-l6l24pco	244	4	almost	almost	RB
cord-350992-l6l24pco	244	5	all	all	DT
cord-350992-l6l24pco	244	6	enrolled	enrol	VBN
cord-350992-l6l24pco	244	7	patients	patient	NNS
cord-350992-l6l24pco	244	8	the	the	DT
cord-350992-l6l24pco	244	9	clinicians	clinician	NNS
cord-350992-l6l24pco	244	10	obtained	obtain	VBD
cord-350992-l6l24pco	244	11	a	a	DT
cord-350992-l6l24pco	244	12	better	well	JJR
cord-350992-l6l24pco	244	13	clinical	clinical	JJ
cord-350992-l6l24pco	244	14	improvement	improvement	NN
cord-350992-l6l24pco	244	15	with	with	IN
cord-350992-l6l24pco	244	16	this	this	DT
cord-350992-l6l24pco	244	17	treatment	treatment	NN
cord-350992-l6l24pco	244	18	when	when	WRB
cord-350992-l6l24pco	244	19	compared	compare	VBN
cord-350992-l6l24pco	244	20	with	with	IN
cord-350992-l6l24pco	244	21	other	other	JJ
cord-350992-l6l24pco	244	22	treatments	treatment	NNS
cord-350992-l6l24pco	244	23	.	.	.
cord-350992-l6l24pco	245	1	Further	further	RB
cord-350992-l6l24pco	245	2	,	,	,
cord-350992-l6l24pco	245	3	viral	viral	JJ
cord-350992-l6l24pco	245	4	load	load	NN
cord-350992-l6l24pco	245	5	rapidly	rapidly	RB
cord-350992-l6l24pco	245	6	decreased	decrease	VBD
cord-350992-l6l24pco	245	7	,	,	,
cord-350992-l6l24pco	245	8	with	with	IN
cord-350992-l6l24pco	245	9	83	83	CD
cord-350992-l6l24pco	245	10	%	%	NN
cord-350992-l6l24pco	245	11	negative	negative	JJ
cord-350992-l6l24pco	245	12	patients	patient	NNS
cord-350992-l6l24pco	245	13	at	at	IN
cord-350992-l6l24pco	245	14	day	day	NN
cord-350992-l6l24pco	245	15	7	7	CD
cord-350992-l6l24pco	245	16	and	and	CC
cord-350992-l6l24pco	245	17	93	93	CD
cord-350992-l6l24pco	245	18	%	%	NN
cord-350992-l6l24pco	245	19	at	at	IN
cord-350992-l6l24pco	245	20	day	day	NN
cord-350992-l6l24pco	245	21	8	8	CD
cord-350992-l6l24pco	245	22	of	of	IN
cord-350992-l6l24pco	245	23	treatment	treatment	NN
cord-350992-l6l24pco	245	24	.	.	.
cord-350992-l6l24pco	246	1	Only	only	RB
cord-350992-l6l24pco	246	2	2	2	CD
cord-350992-l6l24pco	246	3	patients	patient	NNS
cord-350992-l6l24pco	246	4	had	have	VBD
cord-350992-l6l24pco	246	5	still	still	RB
cord-350992-l6l24pco	246	6	detectable	detectable	JJ
cord-350992-l6l24pco	246	7	viral	viral	JJ
cord-350992-l6l24pco	246	8	load	load	NN
cord-350992-l6l24pco	246	9	at	at	IN
cord-350992-l6l24pco	246	10	day	day	NN
cord-350992-l6l24pco	246	11	10	10	CD
cord-350992-l6l24pco	246	12	.	.	.
cord-350992-l6l24pco	247	1	Molina	Molina	NNP
cord-350992-l6l24pco	247	2	and	and	CC
cord-350992-l6l24pco	247	3	colleagues	colleague	NNS
cord-350992-l6l24pco	247	4	[	[	-LRB-
cord-350992-l6l24pco	247	5	146	146	CD
cord-350992-l6l24pco	247	6	]	]	-RRB-
cord-350992-l6l24pco	247	7	studied	study	VBD
cord-350992-l6l24pco	247	8	11	11	CD
cord-350992-l6l24pco	247	9	COVID-19	covid-19	CD
cord-350992-l6l24pco	247	10	patients	patient	NNS
cord-350992-l6l24pco	247	11	(	(	-LRB-
cord-350992-l6l24pco	247	12	10/11	10/11	CD
cord-350992-l6l24pco	247	13	with	with	IN
cord-350992-l6l24pco	247	14	fever	fever	NN
cord-350992-l6l24pco	247	15	and	and	CC
cord-350992-l6l24pco	247	16	nasal	nasal	NN
cord-350992-l6l24pco	247	17	oxygen	oxygen	NN
cord-350992-l6l24pco	247	18	therapy	therapy	NN
cord-350992-l6l24pco	247	19	,	,	,
cord-350992-l6l24pco	247	20	8	8	CD
cord-350992-l6l24pco	247	21	with	with	IN
cord-350992-l6l24pco	247	22	significant	significant	JJ
cord-350992-l6l24pco	247	23	comorbidities	comorbiditie	NNS
cord-350992-l6l24pco	247	24	)	)	-RRB-
cord-350992-l6l24pco	247	25	treated	treat	VBN
cord-350992-l6l24pco	247	26	with	with	IN
cord-350992-l6l24pco	247	27	HCQ	HCQ	NNP
cord-350992-l6l24pco	247	28	plus	plus	CC
cord-350992-l6l24pco	247	29	azithromycin	azithromycin	NNP
cord-350992-l6l24pco	247	30	,	,	,
cord-350992-l6l24pco	247	31	using	use	VBG
cord-350992-l6l24pco	247	32	the	the	DT
cord-350992-l6l24pco	247	33	same	same	JJ
cord-350992-l6l24pco	247	34	dosing	dosing	NN
cord-350992-l6l24pco	247	35	regimen	regimen	NN
cord-350992-l6l24pco	247	36	reported	report	VBN
cord-350992-l6l24pco	247	37	by	by	IN
cord-350992-l6l24pco	247	38	Gautret	Gautret	NNP
cord-350992-l6l24pco	247	39	and	and	CC
cord-350992-l6l24pco	247	40	colleagues	colleague	NNS
cord-350992-l6l24pco	247	41	[	[	-LRB-
cord-350992-l6l24pco	247	42	144	144	CD
cord-350992-l6l24pco	247	43	,	,	,
cord-350992-l6l24pco	247	44	145	145	CD
cord-350992-l6l24pco	247	45	]	]	-RRB-
cord-350992-l6l24pco	247	46	.	.	.
cord-350992-l6l24pco	248	1	One	one	CD
cord-350992-l6l24pco	248	2	patient	patient	NN
cord-350992-l6l24pco	248	3	died	die	VBD
cord-350992-l6l24pco	248	4	and	and	CC
cord-350992-l6l24pco	248	5	2	2	CD
cord-350992-l6l24pco	248	6	were	be	VBD
cord-350992-l6l24pco	248	7	transferred	transfer	VBN
cord-350992-l6l24pco	248	8	to	to	IN
cord-350992-l6l24pco	248	9	ICU	ICU	NNP
cord-350992-l6l24pco	248	10	within	within	IN
cord-350992-l6l24pco	248	11	5	5	CD
cord-350992-l6l24pco	248	12	days	day	NNS
cord-350992-l6l24pco	248	13	after	after	IN
cord-350992-l6l24pco	248	14	treatment	treatment	NN
cord-350992-l6l24pco	248	15	initiation	initiation	NN
cord-350992-l6l24pco	248	16	,	,	,
cord-350992-l6l24pco	248	17	one	one	CD
cord-350992-l6l24pco	248	18	therapy	therapy	NN
cord-350992-l6l24pco	248	19	was	be	VBD
cord-350992-l6l24pco	248	20	discontinued	discontinue	VBN
cord-350992-l6l24pco	248	21	after	after	IN
cord-350992-l6l24pco	248	22	4	4	CD
cord-350992-l6l24pco	248	23	days	day	NNS
cord-350992-l6l24pco	248	24	for	for	IN
cord-350992-l6l24pco	248	25	severe	severe	JJ
cord-350992-l6l24pco	248	26	adverse	adverse	JJ
cord-350992-l6l24pco	248	27	event	event	NN
cord-350992-l6l24pco	248	28	(	(	-LRB-
cord-350992-l6l24pco	248	29	prolongation	prolongation	NN
cord-350992-l6l24pco	248	30	of	of	IN
cord-350992-l6l24pco	248	31	the	the	DT
cord-350992-l6l24pco	248	32	QT	QT	NNP
cord-350992-l6l24pco	248	33	interval	interval	NN
cord-350992-l6l24pco	248	34	)	)	-RRB-
cord-350992-l6l24pco	248	35	,	,	,
cord-350992-l6l24pco	248	36	suggesting	suggest	VBG
cord-350992-l6l24pco	248	37	the	the	DT
cord-350992-l6l24pco	248	38	poor	poor	JJ
cord-350992-l6l24pco	248	39	clinical	clinical	JJ
cord-350992-l6l24pco	248	40	outcome	outcome	NN
cord-350992-l6l24pco	248	41	of	of	IN
cord-350992-l6l24pco	248	42	the	the	DT
cord-350992-l6l24pco	248	43	combined	combine	VBN
cord-350992-l6l24pco	248	44	treatment	treatment	NN
cord-350992-l6l24pco	248	45	.	.	.
cord-350992-l6l24pco	249	1	In	in	IN
cord-350992-l6l24pco	249	2	contrast	contrast	NN
cord-350992-l6l24pco	249	3	with	with	IN
cord-350992-l6l24pco	249	4	results	result	NNS
cord-350992-l6l24pco	249	5	obtained	obtain	VBN
cord-350992-l6l24pco	249	6	by	by	IN
cord-350992-l6l24pco	249	7	[	[	-LRB-
cord-350992-l6l24pco	249	8	144	144	CD
cord-350992-l6l24pco	249	9	,	,	,
cord-350992-l6l24pco	249	10	145	145	CD
cord-350992-l6l24pco	249	11	]	]	-RRB-
cord-350992-l6l24pco	249	12	,	,	,
cord-350992-l6l24pco	249	13	nasopharyngeal	nasopharyngeal	JJ
cord-350992-l6l24pco	249	14	swabs	swab	NNS
cord-350992-l6l24pco	249	15	were	be	VBD
cord-350992-l6l24pco	249	16	still	still	RB
cord-350992-l6l24pco	249	17	positive	positive	JJ
cord-350992-l6l24pco	249	18	for	for	IN
cord-350992-l6l24pco	249	19	viral	viral	JJ
cord-350992-l6l24pco	249	20	RNA	RNA	NNP
cord-350992-l6l24pco	249	21	in	in	IN
cord-350992-l6l24pco	249	22	8/10	8/10	CD
cord-350992-l6l24pco	249	23	patients	patient	NNS
cord-350992-l6l24pco	249	24	at	at	IN
cord-350992-l6l24pco	249	25	days	day	NNS
cord-350992-l6l24pco	249	26	5	5	CD
cord-350992-l6l24pco	249	27	to	to	IN
cord-350992-l6l24pco	249	28	6	6	CD
cord-350992-l6l24pco	249	29	.	.	.
cord-350992-l6l24pco	250	1	Researchers	researcher	NNS
cord-350992-l6l24pco	250	2	concluded	conclude	VBD
cord-350992-l6l24pco	250	3	by	by	IN
cord-350992-l6l24pco	250	4	saying	say	VBG
cord-350992-l6l24pco	250	5	that	that	IN
cord-350992-l6l24pco	250	6	,	,	,
cord-350992-l6l24pco	250	7	in	in	IN
cord-350992-l6l24pco	250	8	their	-PRON-	PRP$
cord-350992-l6l24pco	250	9	experience	experience	NN
cord-350992-l6l24pco	250	10	,	,	,
cord-350992-l6l24pco	250	11	they	-PRON-	PRP
cord-350992-l6l24pco	250	12	found	find	VBD
cord-350992-l6l24pco	250	13	no	no	DT
cord-350992-l6l24pco	250	14	evidence	evidence	NN
cord-350992-l6l24pco	250	15	of	of	IN
cord-350992-l6l24pco	250	16	anti	anti	JJ
cord-350992-l6l24pco	250	17	-	-	JJ
cord-350992-l6l24pco	250	18	viral	viral	JJ
cord-350992-l6l24pco	250	19	activity	activity	NN
cord-350992-l6l24pco	250	20	and	and	CC
cord-350992-l6l24pco	250	21	clinical	clinical	JJ
cord-350992-l6l24pco	250	22	benefit	benefit	NN
cord-350992-l6l24pco	250	23	by	by	IN
cord-350992-l6l24pco	250	24	using	use	VBG
cord-350992-l6l24pco	250	25	the	the	DT
cord-350992-l6l24pco	250	26	combined	combine	VBN
cord-350992-l6l24pco	250	27	therapy	therapy	NN
cord-350992-l6l24pco	250	28	in	in	IN
cord-350992-l6l24pco	250	29	severe	severe	JJ
cord-350992-l6l24pco	250	30	COVID-19	covid-19	NN
cord-350992-l6l24pco	250	31	.	.	.
cord-350992-l6l24pco	251	1	Not	not	RB
cord-350992-l6l24pco	251	2	only	only	RB
cord-350992-l6l24pco	251	3	clinical	clinical	JJ
cord-350992-l6l24pco	251	4	efficacy	efficacy	NN
cord-350992-l6l24pco	251	5	but	but	CC
cord-350992-l6l24pco	251	6	also	also	RB
cord-350992-l6l24pco	251	7	optimal	optimal	JJ
cord-350992-l6l24pco	251	8	dosing	dosing	NN
cord-350992-l6l24pco	251	9	regimen	regimen	NN
cord-350992-l6l24pco	251	10	,	,	,
cord-350992-l6l24pco	251	11	therapeutic	therapeutic	JJ
cord-350992-l6l24pco	251	12	level	level	NN
cord-350992-l6l24pco	251	13	,	,	,
cord-350992-l6l24pco	251	14	duration	duration	NN
cord-350992-l6l24pco	251	15	of	of	IN
cord-350992-l6l24pco	251	16	treatment	treatment	NN
cord-350992-l6l24pco	251	17	and	and	CC
cord-350992-l6l24pco	251	18	pharmacokinetics	pharmacokinetic	NNS
cord-350992-l6l24pco	251	19	in	in	IN
cord-350992-l6l24pco	251	20	patients	patient	NNS
cord-350992-l6l24pco	251	21	with	with	IN
cord-350992-l6l24pco	251	22	different	different	JJ
cord-350992-l6l24pco	251	23	severity	severity	NN
cord-350992-l6l24pco	251	24	degrees	degree	NNS
cord-350992-l6l24pco	251	25	of	of	IN
cord-350992-l6l24pco	251	26	the	the	DT
cord-350992-l6l24pco	251	27	disease	disease	NN
cord-350992-l6l24pco	251	28	are	be	VBP
cord-350992-l6l24pco	251	29	uncertain	uncertain	JJ
cord-350992-l6l24pco	251	30	and	and	CC
cord-350992-l6l24pco	251	31	currently	currently	RB
cord-350992-l6l24pco	251	32	there	there	EX
cord-350992-l6l24pco	251	33	are	be	VBP
cord-350992-l6l24pco	251	34	no	no	DT
cord-350992-l6l24pco	251	35	standard	standard	JJ
cord-350992-l6l24pco	251	36	dosages	dosage	NNS
cord-350992-l6l24pco	251	37	or	or	CC
cord-350992-l6l24pco	251	38	duration	duration	NN
cord-350992-l6l24pco	251	39	of	of	IN
cord-350992-l6l24pco	251	40	treatment	treatment	NN
cord-350992-l6l24pco	251	41	around	around	IN
cord-350992-l6l24pco	251	42	the	the	DT
cord-350992-l6l24pco	251	43	world	world	NN
cord-350992-l6l24pco	251	44	for	for	IN
cord-350992-l6l24pco	251	45	COVID-19	covid-19	JJ
cord-350992-l6l24pco	251	46	patient	patient	JJ
cord-350992-l6l24pco	251	47	treatment	treatment	NN
cord-350992-l6l24pco	251	48	[	[	-LRB-
cord-350992-l6l24pco	251	49	148	148	CD
cord-350992-l6l24pco	251	50	]	]	-RRB-
cord-350992-l6l24pco	252	1	[	[	-LRB-
cord-350992-l6l24pco	252	2	149	149	CD
cord-350992-l6l24pco	252	3	]	]	-RRB-
cord-350992-l6l24pco	253	1	[	[	-LRB-
cord-350992-l6l24pco	253	2	150	150	CD
cord-350992-l6l24pco	253	3	]	]	-RRB-
cord-350992-l6l24pco	253	4	[	[	-LRB-
cord-350992-l6l24pco	253	5	151	151	CD
cord-350992-l6l24pco	253	6	]	]	-RRB-
cord-350992-l6l24pco	253	7	[	[	-LRB-
cord-350992-l6l24pco	253	8	152	152	CD
cord-350992-l6l24pco	253	9	]	]	-RRB-
cord-350992-l6l24pco	253	10	.	.	.
cord-350992-l6l24pco	254	1	Numerous	numerous	JJ
cord-350992-l6l24pco	254	2	studies	study	NNS
cord-350992-l6l24pco	254	3	are	be	VBP
cord-350992-l6l24pco	254	4	under	under	IN
cord-350992-l6l24pco	254	5	way	way	NN
cord-350992-l6l24pco	254	6	to	to	TO
cord-350992-l6l24pco	254	7	evaluate	evaluate	VB
cord-350992-l6l24pco	254	8	their	-PRON-	PRP$
cord-350992-l6l24pco	254	9	efficacy	efficacy	NN
cord-350992-l6l24pco	254	10	in	in	IN
cord-350992-l6l24pco	254	11	treating	treating	NN
cord-350992-l6l24pco	254	12	and	and	CC
cord-350992-l6l24pco	254	13	prevention	prevention	NN
cord-350992-l6l24pco	254	14	of	of	IN
cord-350992-l6l24pco	254	15	COVID-19	COVID-19	NNP
cord-350992-l6l24pco	254	16	and	and	CC
cord-350992-l6l24pco	254	17	to	to	TO
cord-350992-l6l24pco	254	18	establish	establish	VB
cord-350992-l6l24pco	254	19	benefit	benefit	NN
cord-350992-l6l24pco	254	20	versus	versus	IN
cord-350992-l6l24pco	254	21	harm	harm	NN
cord-350992-l6l24pco	254	22	of	of	IN
cord-350992-l6l24pco	254	23	CQ	CQ	NNP
cord-350992-l6l24pco	254	24	/	/	SYM
cord-350992-l6l24pco	254	25	HQC	HQC	NNP
cord-350992-l6l24pco	254	26	treatment	treatment	NN
cord-350992-l6l24pco	254	27	[	[	-LRB-
cord-350992-l6l24pco	254	28	153	153	CD
cord-350992-l6l24pco	254	29	]	]	-RRB-
cord-350992-l6l24pco	254	30	.	.	.
cord-350992-l6l24pco	255	1	Notwithstanding	notwithstanding	IN
cord-350992-l6l24pco	255	2	,	,	,
cord-350992-l6l24pco	255	3	in	in	IN
cord-350992-l6l24pco	255	4	the	the	DT
cord-350992-l6l24pco	255	5	emergency	emergency	NN
cord-350992-l6l24pco	255	6	phase	phase	NN
cord-350992-l6l24pco	255	7	of	of	IN
cord-350992-l6l24pco	255	8	COVID-19	covid-19	DT
cord-350992-l6l24pco	255	9	pandemic	pandemic	NN
cord-350992-l6l24pco	255	10	many	many	JJ
cord-350992-l6l24pco	255	11	old	old	JJ
cord-350992-l6l24pco	255	12	drugs	drug	NNS
cord-350992-l6l24pco	255	13	have	have	VBP
cord-350992-l6l24pco	255	14	been	be	VBN
cord-350992-l6l24pco	255	15	off	off	IN
cord-350992-l6l24pco	255	16	-	-	HYPH
cord-350992-l6l24pco	255	17	label	label	NN
cord-350992-l6l24pco	255	18	used	use	VBN
cord-350992-l6l24pco	255	19	for	for	IN
cord-350992-l6l24pco	255	20	the	the	DT
cord-350992-l6l24pco	255	21	treatment	treatment	NN
cord-350992-l6l24pco	255	22	of	of	IN
cord-350992-l6l24pco	255	23	the	the	DT
cord-350992-l6l24pco	255	24	infection	infection	NN
cord-350992-l6l24pco	255	25	,	,	,
cord-350992-l6l24pco	255	26	based	base	VBN
cord-350992-l6l24pco	255	27	only	only	RB
cord-350992-l6l24pco	255	28	on	on	IN
cord-350992-l6l24pco	255	29	theoretical	theoretical	JJ
cord-350992-l6l24pco	255	30	or	or	CC
cord-350992-l6l24pco	255	31	in	in	IN
cord-350992-l6l24pco	255	32	vitro	vitro	FW
cord-350992-l6l24pco	255	33	efficacy	efficacy	NN
cord-350992-l6l24pco	255	34	and	and	CC
cord-350992-l6l24pco	255	35	without	without	IN
cord-350992-l6l24pco	255	36	enough	enough	JJ
cord-350992-l6l24pco	255	37	clinical	clinical	JJ
cord-350992-l6l24pco	255	38	evidence	evidence	NN
cord-350992-l6l24pco	255	39	based	base	VBN
cord-350992-l6l24pco	255	40	on	on	IN
cord-350992-l6l24pco	255	41	randomized	randomized	JJ
cord-350992-l6l24pco	255	42	clinical	clinical	JJ
cord-350992-l6l24pco	255	43	trial	trial	NN
cord-350992-l6l24pco	255	44	.	.	.
cord-350992-l6l24pco	256	1	J	J	NNP
cord-350992-l6l24pco	256	2	o	o	NN
cord-350992-l6l24pco	256	3	u	u	NN
cord-350992-l6l24pco	256	4	r	r	NN
cord-350992-l6l24pco	256	5	n	n	NN
cord-350992-l6l24pco	256	6	a	a	DT
cord-350992-l6l24pco	256	7	l	l	NN
cord-350992-l6l24pco	256	8	P	p	NN
cord-350992-l6l24pco	256	9	r	r	NN
cord-350992-l6l24pco	256	10	e	e	NN
cord-350992-l6l24pco	256	11	-p	-p	NN
cord-350992-l6l24pco	257	1	r	r	LS
cord-350992-l6l24pco	258	1	o	o	UH
cord-350992-l6l24pco	259	1	o	o	UH
cord-350992-l6l24pco	259	2	f	f	NNP
cord-350992-l6l24pco	260	1	As	as	IN
cord-350992-l6l24pco	260	2	we	-PRON-	PRP
cord-350992-l6l24pco	260	3	have	have	VBP
cord-350992-l6l24pco	260	4	described	describe	VBN
cord-350992-l6l24pco	260	5	,	,	,
cord-350992-l6l24pco	260	6	CQ	CQ	NNP
cord-350992-l6l24pco	260	7	/	/	SYM
cord-350992-l6l24pco	260	8	HCQ	HCQ	NNP
cord-350992-l6l24pco	260	9	are	be	VBP
cord-350992-l6l24pco	260	10	likely	likely	JJ
cord-350992-l6l24pco	260	11	to	to	TO
cord-350992-l6l24pco	260	12	have	have	VB
cord-350992-l6l24pco	260	13	:	:	:
cord-350992-l6l24pco	260	14	(	(	-LRB-
cord-350992-l6l24pco	260	15	1	1	LS
cord-350992-l6l24pco	260	16	)	)	-RRB-
cord-350992-l6l24pco	260	17	a	a	DT
cord-350992-l6l24pco	260	18	direct	direct	JJ
cord-350992-l6l24pco	260	19	antiviral	antiviral	JJ
cord-350992-l6l24pco	260	20	action	action	NN
cord-350992-l6l24pco	260	21	stopping	stop	VBG
cord-350992-l6l24pco	260	22	viral	viral	JJ
cord-350992-l6l24pco	260	23	infection	infection	NN
cord-350992-l6l24pco	260	24	in	in	IN
cord-350992-l6l24pco	260	25	several	several	JJ
cord-350992-l6l24pco	260	26	steps	step	NNS
cord-350992-l6l24pco	260	27	;	;	:
cord-350992-l6l24pco	260	28	(	(	-LRB-
cord-350992-l6l24pco	260	29	2	2	LS
cord-350992-l6l24pco	260	30	)	)	-RRB-
cord-350992-l6l24pco	260	31	a	a	DT
cord-350992-l6l24pco	260	32	hypothetical	hypothetical	JJ
cord-350992-l6l24pco	260	33	ability	ability	NN
cord-350992-l6l24pco	260	34	to	to	TO
cord-350992-l6l24pco	260	35	attenuate	attenuate	VB
cord-350992-l6l24pco	260	36	the	the	DT
cord-350992-l6l24pco	260	37	progression	progression	NN
cord-350992-l6l24pco	260	38	of	of	IN
cord-350992-l6l24pco	260	39	COVID-19	COVID-19	NNP
cord-350992-l6l24pco	260	40	to	to	IN
cord-350992-l6l24pco	260	41	severe	severe	JJ
cord-350992-l6l24pco	260	42	disease	disease	NN
cord-350992-l6l24pco	260	43	exploiting	exploit	VBG
cord-350992-l6l24pco	260	44	its	-PRON-	PRP$
cord-350992-l6l24pco	260	45	inflammatory	inflammatory	JJ
cord-350992-l6l24pco	260	46	mechanisms	mechanism	NNS
cord-350992-l6l24pco	260	47	,	,	,
cord-350992-l6l24pco	260	48	but	but	CC
cord-350992-l6l24pco	260	49	also	also	RB
cord-350992-l6l24pco	260	50	(	(	-LRB-
cord-350992-l6l24pco	260	51	3	3	LS
cord-350992-l6l24pco	260	52	)	)	-RRB-
cord-350992-l6l24pco	260	53	through	through	IN
cord-350992-l6l24pco	260	54	its	-PRON-	PRP$
cord-350992-l6l24pco	260	55	potential	potential	JJ
cord-350992-l6l24pco	260	56	anti	anti	JJ
cord-350992-l6l24pco	260	57	-	-	JJ
cord-350992-l6l24pco	260	58	thrombotic	thrombotic	JJ
cord-350992-l6l24pco	260	59	effect	effect	NN
cord-350992-l6l24pco	260	60	.	.	.
cord-350992-l6l24pco	261	1	Based	base	VBN
cord-350992-l6l24pco	261	2	on	on	IN
cord-350992-l6l24pco	261	3	our	-PRON-	PRP$
cord-350992-l6l24pco	261	4	review	review	NN
cord-350992-l6l24pco	261	5	and	and	CC
cord-350992-l6l24pco	261	6	because	because	IN
cord-350992-l6l24pco	261	7	of	of	IN
cord-350992-l6l24pco	261	8	their	-PRON-	PRP$
cord-350992-l6l24pco	261	9	minimal	minimal	JJ
cord-350992-l6l24pco	261	10	toxicity	toxicity	NN
cord-350992-l6l24pco	261	11	profile	profile	NN
cord-350992-l6l24pco	261	12	and	and	CC
cord-350992-l6l24pco	261	13	complex	complex	JJ
cord-350992-l6l24pco	261	14	action	action	NN
cord-350992-l6l24pco	261	15	,	,	,
cord-350992-l6l24pco	261	16	we	-PRON-	PRP
cord-350992-l6l24pco	261	17	suggest	suggest	VBP
cord-350992-l6l24pco	261	18	to	to	TO
cord-350992-l6l24pco	261	19	use	use	VB
cord-350992-l6l24pco	261	20	CQ	CQ	NNP
cord-350992-l6l24pco	261	21	/	/	SYM
cord-350992-l6l24pco	261	22	HCQ	HCQ	NNP
cord-350992-l6l24pco	261	23	CQ	CQ	NNP
cord-350992-l6l24pco	261	24	beyond	beyond	IN
cord-350992-l6l24pco	261	25	5	5	CD
cord-350992-l6l24pco	261	26	-	-	SYM
cord-350992-l6l24pco	261	27	10	10	CD
cord-350992-l6l24pco	261	28	days	day	NNS
cord-350992-l6l24pco	261	29	of	of	IN
cord-350992-l6l24pco	261	30	treatment	treatment	NN
cord-350992-l6l24pco	261	31	in	in	IN
cord-350992-l6l24pco	261	32	patients	patient	NNS
cord-350992-l6l24pco	261	33	with	with	IN
cord-350992-l6l24pco	261	34	COVID-19	COVID-19	NNP
cord-350992-l6l24pco	261	35	according	accord	VBG
cord-350992-l6l24pco	261	36	to	to	IN
cord-350992-l6l24pco	261	37	the	the	DT
cord-350992-l6l24pco	261	38	hypothesis	hypothesis	NN
cord-350992-l6l24pco	261	39	that	that	IN
cord-350992-l6l24pco	261	40	their	-PRON-	PRP$
cord-350992-l6l24pco	261	41	utility	utility	NN
cord-350992-l6l24pco	261	42	can	can	MD
cord-350992-l6l24pco	261	43	extend	extend	VB
cord-350992-l6l24pco	261	44	also	also	RB
cord-350992-l6l24pco	261	45	after	after	IN
cord-350992-l6l24pco	261	46	ending	end	VBG
cord-350992-l6l24pco	261	47	Sars	Sars	NNP
cord-350992-l6l24pco	261	48	-	-	HYPH
cord-350992-l6l24pco	261	49	Cov-2	Cov-2	NNP
cord-350992-l6l24pco	261	50	high	high	JJ
cord-350992-l6l24pco	261	51	replication	replication	NN
cord-350992-l6l24pco	261	52	phase	phase	NN
cord-350992-l6l24pco	261	53	and	and	CC
cord-350992-l6l24pco	261	54	considering	consider	VBG
cord-350992-l6l24pco	261	55	also	also	RB
cord-350992-l6l24pco	261	56	the	the	DT
cord-350992-l6l24pco	261	57	possibility	possibility	NN
cord-350992-l6l24pco	261	58	of	of	IN
cord-350992-l6l24pco	261	59	a	a	DT
cord-350992-l6l24pco	261	60	reactivation	reactivation	NN
cord-350992-l6l24pco	261	61	of	of	IN
cord-350992-l6l24pco	261	62	the	the	DT
cord-350992-l6l24pco	261	63	infection	infection	NN
cord-350992-l6l24pco	261	64	[	[	-LRB-
cord-350992-l6l24pco	261	65	154	154	CD
cord-350992-l6l24pco	261	66	]	]	-RRB-
cord-350992-l6l24pco	261	67	.	.	.
cord-350992-l6l24pco	262	1	Randomized	randomized	JJ
cord-350992-l6l24pco	262	2	controlled	control	VBN
cord-350992-l6l24pco	262	3	studies	study	NNS
cord-350992-l6l24pco	262	4	and	and	CC
cord-350992-l6l24pco	262	5	observational	observational	JJ
cord-350992-l6l24pco	262	6	outcome	outcome	NN
cord-350992-l6l24pco	262	7	registries	registry	NNS
cord-350992-l6l24pco	262	8	focused	focus	VBD
cord-350992-l6l24pco	262	9	on	on	IN
cord-350992-l6l24pco	262	10	efficacy	efficacy	NN
cord-350992-l6l24pco	262	11	,	,	,
cord-350992-l6l24pco	262	12	duration	duration	NN
cord-350992-l6l24pco	262	13	and	and	CC
cord-350992-l6l24pco	262	14	toxicities	toxicity	NNS
cord-350992-l6l24pco	262	15	of	of	IN
cord-350992-l6l24pco	262	16	treatment	treatment	NN
cord-350992-l6l24pco	262	17	with	with	IN
cord-350992-l6l24pco	262	18	these	these	DT
cord-350992-l6l24pco	262	19	drugs	drug	NNS
cord-350992-l6l24pco	262	20	could	could	MD
cord-350992-l6l24pco	262	21	be	be	VB
cord-350992-l6l24pco	262	22	useful	useful	JJ
cord-350992-l6l24pco	262	23	to	to	TO
cord-350992-l6l24pco	262	24	understand	understand	VB
cord-350992-l6l24pco	262	25	their	-PRON-	PRP$
cord-350992-l6l24pco	262	26	real	real	JJ
cord-350992-l6l24pco	262	27	effectiveness	effectiveness	NN
cord-350992-l6l24pco	262	28	while	while	IN
cord-350992-l6l24pco	262	29	more	more	RBR
cord-350992-l6l24pco	262	30	specific	specific	JJ
cord-350992-l6l24pco	262	31	anti	anti	JJ
cord-350992-l6l24pco	262	32	-	-	JJ
cord-350992-l6l24pco	262	33	COVID-19	covid-19	JJ
cord-350992-l6l24pco	262	34	drugs	drug	NNS
cord-350992-l6l24pco	262	35	are	be	VBP
cord-350992-l6l24pco	262	36	available	available	JJ
cord-350992-l6l24pco	262	37	.	.	.
cord-350992-l6l24pco	262	38	 	 	_SP
cord-350992-l6l24pco	263	1	This	this	DT
cord-350992-l6l24pco	263	2	study	study	NN
cord-350992-l6l24pco	263	3	was	be	VBD
cord-350992-l6l24pco	263	4	partly	partly	RB
cord-350992-l6l24pco	263	5	supported	support	VBN
cord-350992-l6l24pco	263	6	by	by	IN
cord-350992-l6l24pco	263	7	the	the	DT
cord-350992-l6l24pco	263	8	University	University	NNP
cord-350992-l6l24pco	263	9	of	of	IN
cord-350992-l6l24pco	263	10	Brescia	Brescia	NNP
cord-350992-l6l24pco	263	11	(	(	-LRB-
cord-350992-l6l24pco	263	12	fondi	fondi	NNP
cord-350992-l6l24pco	263	13	ex	ex	NNP
cord-350992-l6l24pco	263	14	60	60	CD
cord-350992-l6l24pco	263	15	%	%	NN
cord-350992-l6l24pco	263	16	to	to	IN
cord-350992-l6l24pco	263	17	Eugenia	Eugenia	NNP
cord-350992-l6l24pco	263	18	Quiros	Quiros	NNP
cord-350992-l6l24pco	263	19	-	-	HYPH
cord-350992-l6l24pco	263	20	Roldan	Roldan	NNP
cord-350992-l6l24pco	263	21	,	,	,
cord-350992-l6l24pco	263	22	Giorgio	Giorgio	NNP
cord-350992-l6l24pco	263	23	Biasiotto	Biasiotto	NNP
cord-350992-l6l24pco	263	24	and	and	CC
cord-350992-l6l24pco	263	25	Isabella	Isabella	NNP
cord-350992-l6l24pco	263	26	Zanella	Zanella	NNP
cord-350992-l6l24pco	263	27	)	)	-RRB-
cord-350992-l6l24pco	263	28	.	.	.
cord-350992-l6l24pco	264	1	The	the	DT
cord-350992-l6l24pco	264	2	authors	author	NNS
cord-350992-l6l24pco	264	3	declare	declare	VBP
cord-350992-l6l24pco	264	4	the	the	DT
cord-350992-l6l24pco	264	5	following	follow	VBG
cord-350992-l6l24pco	264	6	financial	financial	JJ
cord-350992-l6l24pco	264	7	interests	interest	NNS
cord-350992-l6l24pco	264	8	/	/	SYM
cord-350992-l6l24pco	264	9	personal	personal	JJ
cord-350992-l6l24pco	264	10	relationships	relationship	NNS
cord-350992-l6l24pco	264	11	which	which	WDT
cord-350992-l6l24pco	264	12	may	may	MD
cord-350992-l6l24pco	264	13	be	be	VB
cord-350992-l6l24pco	264	14	considered	consider	VBN
cord-350992-l6l24pco	264	15	as	as	IN
cord-350992-l6l24pco	264	16	 	 	_SP
cord-350992-l6l24pco	264	17	Of	of	IN
cord-350992-l6l24pco	264	18	chloroquine	chloroquine	NNP
cord-350992-l6l24pco	264	19	and	and	CC
cord-350992-l6l24pco	264	20	COVID-19	covid-19	VB
cord-350992-l6l24pco	264	21	Viral	viral	JJ
cord-350992-l6l24pco	264	22	infection	infection	NN
cord-350992-l6l24pco	264	23	and	and	CC
cord-350992-l6l24pco	264	24	iron	iron	NN
cord-350992-l6l24pco	264	25	metabolism	metabolism	NN
cord-350992-l6l24pco	264	26	Hepcidin	Hepcidin	NNP
cord-350992-l6l24pco	264	27	and	and	CC
cord-350992-l6l24pco	264	28	the	the	DT
cord-350992-l6l24pco	264	29	iron	iron	NN
cord-350992-l6l24pco	264	30	-	-	HYPH
cord-350992-l6l24pco	264	31	infection	infection	NN
cord-350992-l6l24pco	264	32	axis	axis	NN
cord-350992-l6l24pco	264	33	Iron	iron	NN
cord-350992-l6l24pco	264	34	and	and	CC
cord-350992-l6l24pco	264	35	infection	infection	NN
cord-350992-l6l24pco	264	36	Guidelines	guideline	NNS
cord-350992-l6l24pco	264	37	for	for	IN
cord-350992-l6l24pco	264	38	the	the	DT
cord-350992-l6l24pco	264	39	use	use	NN
cord-350992-l6l24pco	264	40	and	and	CC
cord-350992-l6l24pco	264	41	interpretation	interpretation	NN
cord-350992-l6l24pco	264	42	of	of	IN
cord-350992-l6l24pco	264	43	assays	assay	NNS
cord-350992-l6l24pco	264	44	for	for	IN
cord-350992-l6l24pco	264	45	monitoring	monitor	VBG
cord-350992-l6l24pco	264	46	autophagy	autophagy	NN
cord-350992-l6l24pco	264	47	Effects	effect	NNS
cord-350992-l6l24pco	264	48	of	of	IN
cord-350992-l6l24pco	264	49	chloroquine	chloroquine	NN
cord-350992-l6l24pco	264	50	on	on	IN
cord-350992-l6l24pco	264	51	viral	viral	JJ
cord-350992-l6l24pco	264	52	infections	infection	NNS
cord-350992-l6l24pco	264	53	:	:	:
cord-350992-l6l24pco	264	54	an	an	DT
cord-350992-l6l24pco	264	55	old	old	JJ
cord-350992-l6l24pco	264	56	drug	drug	NN
cord-350992-l6l24pco	264	57	against	against	IN
cord-350992-l6l24pco	264	58	today	today	NN
cord-350992-l6l24pco	264	59	's	's	POS
cord-350992-l6l24pco	264	60	diseases	disease	NNS
cord-350992-l6l24pco	264	61	?	?	.
cord-350992-l6l24pco	265	1	Coronaviruses	coronaviruse	NNS
cord-350992-l6l24pco	265	2	:	:	:
cord-350992-l6l24pco	266	1	an	an	DT
cord-350992-l6l24pco	266	2	overview	overview	NN
cord-350992-l6l24pco	266	3	of	of	IN
cord-350992-l6l24pco	266	4	their	-PRON-	PRP$
cord-350992-l6l24pco	266	5	replication	replication	NN
cord-350992-l6l24pco	266	6	and	and	CC
cord-350992-l6l24pco	266	7	pathogenesis	pathogenesis	NN
cord-350992-l6l24pco	266	8	Remdesivir	Remdesivir	NNP
cord-350992-l6l24pco	266	9	and	and	CC
cord-350992-l6l24pco	266	10	chloroquine	chloroquine	NN
cord-350992-l6l24pco	266	11	effectively	effectively	RB
cord-350992-l6l24pco	266	12	inhibit	inhibit	VBP
cord-350992-l6l24pco	266	13	the	the	DT
cord-350992-l6l24pco	266	14	recently	recently	RB
cord-350992-l6l24pco	266	15	emerged	emerge	VBN
cord-350992-l6l24pco	266	16	novel	novel	JJ
cord-350992-l6l24pco	266	17	coronavirus	coronavirus	NN
cord-350992-l6l24pco	266	18	(	(	-LRB-
cord-350992-l6l24pco	266	19	2019-nCoV	2019-ncov	CD
cord-350992-l6l24pco	266	20	)	)	-RRB-
cord-350992-l6l24pco	266	21	in	in	IN
cord-350992-l6l24pco	266	22	vitro	vitro	FW
cord-350992-l6l24pco	266	23	Hydroxychloroquine	Hydroxychloroquine	NNP
cord-350992-l6l24pco	266	24	,	,	,
cord-350992-l6l24pco	266	25	a	a	DT
cord-350992-l6l24pco	266	26	less	less	RBR
cord-350992-l6l24pco	266	27	toxic	toxic	JJ
cord-350992-l6l24pco	266	28	derivative	derivative	NN
cord-350992-l6l24pco	266	29	of	of	IN
cord-350992-l6l24pco	266	30	chloroquine	chloroquine	NN
cord-350992-l6l24pco	266	31	,	,	,
cord-350992-l6l24pco	266	32	is	be	VBZ
cord-350992-l6l24pco	266	33	effective	effective	JJ
cord-350992-l6l24pco	266	34	in	in	IN
cord-350992-l6l24pco	266	35	inhibiting	inhibit	VBG
cord-350992-l6l24pco	266	36	SARS	SARS	NNP
cord-350992-l6l24pco	266	37	-	-	HYPH
cord-350992-l6l24pco	266	38	CoV-2	CoV-2	NNP
cord-350992-l6l24pco	266	39	infection	infection	NN
cord-350992-l6l24pco	267	1	in	in	IN
cord-350992-l6l24pco	267	2	vitro	vitro	FW
cord-350992-l6l24pco	268	1	In	in	IN
cord-350992-l6l24pco	268	2	Vitro	Vitro	NNP
cord-350992-l6l24pco	268	3	Antiviral	Antiviral	NNP
cord-350992-l6l24pco	268	4	Activity	Activity	NNP
cord-350992-l6l24pco	268	5	and	and	CC
cord-350992-l6l24pco	268	6	Projection	Projection	NNP
cord-350992-l6l24pco	268	7	of	of	IN
cord-350992-l6l24pco	268	8	Optimized	Optimized	NNP
cord-350992-l6l24pco	268	9	Dosing	Dosing	NNP
cord-350992-l6l24pco	268	10	Design	Design	NNP
cord-350992-l6l24pco	268	11	of	of	IN
cord-350992-l6l24pco	268	12	Hydroxychloroquine	Hydroxychloroquine	NNP
cord-350992-l6l24pco	268	13	for	for	IN
cord-350992-l6l24pco	268	14	the	the	DT
cord-350992-l6l24pco	268	15	Treatment	Treatment	NNP
cord-350992-l6l24pco	268	16	of	of	IN
cord-350992-l6l24pco	268	17	Severe	severe	JJ
cord-350992-l6l24pco	268	18	Acute	acute	JJ
cord-350992-l6l24pco	268	19	Respiratory	Respiratory	NNP
cord-350992-l6l24pco	268	20	Syndrome	Syndrome	NNP
cord-350992-l6l24pco	268	21	Coronavirus	Coronavirus	NNP
cord-350992-l6l24pco	268	22	2	2	CD
cord-350992-l6l24pco	269	1	(	(	-LRB-
cord-350992-l6l24pco	269	2	SARS	SARS	NNP
cord-350992-l6l24pco	269	3	-	-	HYPH
cord-350992-l6l24pco	269	4	CoV-2	CoV-2	NNP
cord-350992-l6l24pco	269	5	)	)	-RRB-
cord-350992-l6l24pco	270	1	New	new	JJ
cord-350992-l6l24pco	270	2	insights	insight	NNS
cord-350992-l6l24pco	270	3	on	on	IN
cord-350992-l6l24pco	270	4	the	the	DT
cord-350992-l6l24pco	270	5	antiviral	antiviral	JJ
cord-350992-l6l24pco	270	6	effects	effect	NNS
cord-350992-l6l24pco	270	7	of	of	IN
cord-350992-l6l24pco	270	8	chloroquine	chloroquine	NN
cord-350992-l6l24pco	270	9	against	against	IN
cord-350992-l6l24pco	270	10	coronavirus	coronavirus	NN
cord-350992-l6l24pco	270	11	:	:	:
cord-350992-l6l24pco	270	12	what	what	WP
cord-350992-l6l24pco	270	13	to	to	TO
cord-350992-l6l24pco	270	14	expect	expect	VB
cord-350992-l6l24pco	270	15	for	for	IN
cord-350992-l6l24pco	270	16	COVID-19	covid-19	NN
cord-350992-l6l24pco	270	17	?	?	.
cord-350992-l6l24pco	271	1	Chloroquine	Chloroquine	NNP
cord-350992-l6l24pco	271	2	is	be	VBZ
cord-350992-l6l24pco	271	3	a	a	DT
cord-350992-l6l24pco	271	4	potent	potent	JJ
cord-350992-l6l24pco	271	5	inhibitor	inhibitor	NN
cord-350992-l6l24pco	271	6	of	of	IN
cord-350992-l6l24pco	271	7	SARS	SARS	NNP
cord-350992-l6l24pco	271	8	coronavirus	coronavirus	NN
cord-350992-l6l24pco	271	9	infection	infection	NN
cord-350992-l6l24pco	271	10	and	and	CC
cord-350992-l6l24pco	271	11	spread	spread	VBD
cord-350992-l6l24pco	271	12	Structural	structural	JJ
cord-350992-l6l24pco	271	13	,	,	,
cord-350992-l6l24pco	271	14	glycosylation	glycosylation	NN
cord-350992-l6l24pco	271	15	and	and	CC
cord-350992-l6l24pco	271	16	antigenic	antigenic	JJ
cord-350992-l6l24pco	271	17	variation	variation	NN
cord-350992-l6l24pco	271	18	between	between	IN
cord-350992-l6l24pco	271	19	2019	2019	CD
cord-350992-l6l24pco	271	20	novel	novel	JJ
cord-350992-l6l24pco	271	21	coronavirus	coronavirus	NN
cord-350992-l6l24pco	271	22	(	(	-LRB-
cord-350992-l6l24pco	271	23	2019-nCoV	2019-ncov	CD
cord-350992-l6l24pco	271	24	)	)	-RRB-
cord-350992-l6l24pco	271	25	and	and	CC
cord-350992-l6l24pco	271	26	SARS	SARS	NNP
cord-350992-l6l24pco	271	27	coronavirus	coronavirus	NN
cord-350992-l6l24pco	271	28	Structural	structural	JJ
cord-350992-l6l24pco	271	29	and	and	CC
cord-350992-l6l24pco	271	30	molecular	molecular	JJ
cord-350992-l6l24pco	271	31	modeling	modeling	NN
cord-350992-l6l24pco	271	32	studies	study	NNS
cord-350992-l6l24pco	271	33	reveal	reveal	VBP
cord-350992-l6l24pco	271	34	a	a	DT
cord-350992-l6l24pco	271	35	new	new	JJ
cord-350992-l6l24pco	271	36	mechanism	mechanism	NN
cord-350992-l6l24pco	271	37	of	of	IN
cord-350992-l6l24pco	271	38	action	action	NN
cord-350992-l6l24pco	271	39	of	of	IN
cord-350992-l6l24pco	271	40	chloroquine	chloroquine	NNP
cord-350992-l6l24pco	271	41	and	and	CC
cord-350992-l6l24pco	271	42	hydroxychloroquine	hydroxychloroquine	NN
cord-350992-l6l24pco	271	43	against	against	IN
cord-350992-l6l24pco	271	44	SARS	SARS	NNP
cord-350992-l6l24pco	271	45	-	-	HYPH
cord-350992-l6l24pco	271	46	CoV-2	CoV-2	NNP
cord-350992-l6l24pco	271	47	infection	infection	NN
cord-350992-l6l24pco	272	1	A	a	DT
cord-350992-l6l24pco	272	2	chloroquine	chloroquine	NN
cord-350992-l6l24pco	272	3	-	-	HYPH
cord-350992-l6l24pco	272	4	induced	induce	VBN
cord-350992-l6l24pco	272	5	macrophage	macrophage	NN
cord-350992-l6l24pco	272	6	-	-	HYPH
cord-350992-l6l24pco	272	7	preconditioning	precondition	VBG
cord-350992-l6l24pco	272	8	strategy	strategy	NN
cord-350992-l6l24pco	272	9	for	for	IN
cord-350992-l6l24pco	272	10	improved	improve	VBN
cord-350992-l6l24pco	272	11	nanodelivery	nanodelivery	NN
cord-350992-l6l24pco	272	12	.	.	.
cord-350992-l6l24pco	273	1	Sci	Sci	NNP
cord-350992-l6l24pco	273	2	Rep	Rep	NNP
cord-350992-l6l24pco	273	3	Clathrindependent	Clathrindependent	NNP
cord-350992-l6l24pco	273	4	entry	entry	NN
cord-350992-l6l24pco	273	5	of	of	IN
cord-350992-l6l24pco	273	6	severe	severe	JJ
cord-350992-l6l24pco	273	7	acute	acute	JJ
cord-350992-l6l24pco	273	8	respiratory	respiratory	JJ
cord-350992-l6l24pco	273	9	syndrome	syndrome	NN
cord-350992-l6l24pco	273	10	coronavirus	coronavirus	NN
cord-350992-l6l24pco	273	11	into	into	IN
cord-350992-l6l24pco	273	12	target	target	NN
cord-350992-l6l24pco	273	13	cells	cell	NNS
cord-350992-l6l24pco	273	14	expressing	express	VBG
cord-350992-l6l24pco	273	15	ACE2	ACE2	NNP
cord-350992-l6l24pco	273	16	with	with	IN
cord-350992-l6l24pco	273	17	the	the	DT
cord-350992-l6l24pco	273	18	cytoplasmic	cytoplasmic	JJ
cord-350992-l6l24pco	273	19	tail	tail	NN
cord-350992-l6l24pco	273	20	deleted	delete	VBN
cord-350992-l6l24pco	274	1	SARS	SARS	NNP
cord-350992-l6l24pco	274	2	-	-	HYPH
cord-350992-l6l24pco	274	3	CoV-2	CoV-2	NNP
cord-350992-l6l24pco	274	4	Cell	Cell	NNP
cord-350992-l6l24pco	274	5	Entry	entry	NN
cord-350992-l6l24pco	274	6	Depends	depend	VBZ
cord-350992-l6l24pco	274	7	on	on	IN
cord-350992-l6l24pco	274	8	ACE2	ACE2	NNP
cord-350992-l6l24pco	274	9	and	and	CC
cord-350992-l6l24pco	274	10	TMPRSS2	TMPRSS2	NNP
cord-350992-l6l24pco	274	11	and	and	CC
cord-350992-l6l24pco	274	12	Is	be	VBZ
cord-350992-l6l24pco	274	13	Blocked	block	VBN
cord-350992-l6l24pco	274	14	by	by	IN
cord-350992-l6l24pco	274	15	a	a	DT
cord-350992-l6l24pco	274	16	Clinically	clinically	RB
cord-350992-l6l24pco	274	17	Proven	prove	VBN
cord-350992-l6l24pco	274	18	Protease	Protease	NNP
cord-350992-l6l24pco	274	19	Inhibitor	Inhibitor	NNP
cord-350992-l6l24pco	274	20	SARS	SARS	NNP
cord-350992-l6l24pco	274	21	coronavirus	coronavirus	NN
cord-350992-l6l24pco	274	22	entry	entry	NN
cord-350992-l6l24pco	274	23	into	into	IN
cord-350992-l6l24pco	274	24	host	host	NN
cord-350992-l6l24pco	274	25	cells	cell	NNS
cord-350992-l6l24pco	274	26	through	through	IN
cord-350992-l6l24pco	274	27	a	a	DT
cord-350992-l6l24pco	274	28	novel	novel	JJ
cord-350992-l6l24pco	274	29	clathrin	clathrin	NN
cord-350992-l6l24pco	274	30	-	-	:
cord-350992-l6l24pco	274	31	and	and	CC
cord-350992-l6l24pco	274	32	caveolae	caveolae	JJ
cord-350992-l6l24pco	274	33	-	-	HYPH
cord-350992-l6l24pco	274	34	independent	independent	JJ
cord-350992-l6l24pco	274	35	endocytic	endocytic	JJ
cord-350992-l6l24pco	274	36	pathway	pathway	NN
cord-350992-l6l24pco	274	37	Inhibition	inhibition	NN
cord-350992-l6l24pco	274	38	of	of	IN
cord-350992-l6l24pco	274	39	Chikungunya	Chikungunya	NNP
cord-350992-l6l24pco	274	40	virus	virus	NN
cord-350992-l6l24pco	274	41	infection	infection	NN
cord-350992-l6l24pco	274	42	in	in	IN
cord-350992-l6l24pco	274	43	cultured	cultured	JJ
cord-350992-l6l24pco	274	44	human	human	JJ
cord-350992-l6l24pco	274	45	muscle	muscle	NN
cord-350992-l6l24pco	274	46	cells	cell	NNS
cord-350992-l6l24pco	274	47	by	by	IN
cord-350992-l6l24pco	274	48	furin	furin	NN
cord-350992-l6l24pco	274	49	inhibitors	inhibitor	NNS
cord-350992-l6l24pco	274	50	:	:	:
cord-350992-l6l24pco	274	51	impairment	impairment	NN
cord-350992-l6l24pco	274	52	of	of	IN
cord-350992-l6l24pco	274	53	the	the	DT
cord-350992-l6l24pco	274	54	maturation	maturation	NN
cord-350992-l6l24pco	274	55	of	of	IN
cord-350992-l6l24pco	274	56	the	the	DT
cord-350992-l6l24pco	274	57	E2	E2	NNP
cord-350992-l6l24pco	274	58	surface	surface	NN
cord-350992-l6l24pco	274	59	glycoprotein	glycoprotein	NN
cord-350992-l6l24pco	274	60	Coronavirus	Coronavirus	NNP
cord-350992-l6l24pco	274	61	envelope	envelope	NN
cord-350992-l6l24pco	274	62	protein	protein	NN
cord-350992-l6l24pco	274	63	:	:	:
cord-350992-l6l24pco	274	64	current	current	JJ
cord-350992-l6l24pco	274	65	knowledge	knowledge	NN
cord-350992-l6l24pco	274	66	Emerging	emerge	VBG
cord-350992-l6l24pco	274	67	Regulatory	regulatory	JJ
cord-350992-l6l24pco	274	68	Roles	Roles	NNPS
cord-350992-l6l24pco	274	69	of	of	IN
cord-350992-l6l24pco	274	70	Dual	Dual	NNP
cord-350992-l6l24pco	274	71	-	-	HYPH
cord-350992-l6l24pco	274	72	Specificity	specificity	NN
cord-350992-l6l24pco	274	73	Phosphatases	Phosphatases	NNP
cord-350992-l6l24pco	274	74	in	in	IN
cord-350992-l6l24pco	274	75	Inflammatory	Inflammatory	NNP
cord-350992-l6l24pco	274	76	Airway	Airway	NNP
cord-350992-l6l24pco	274	77	Disease	Disease	NNP
cord-350992-l6l24pco	274	78	Inhibition	Inhibition	NNP
cord-350992-l6l24pco	274	79	of	of	IN
cord-350992-l6l24pco	274	80	human	human	JJ
cord-350992-l6l24pco	274	81	coronavirus	coronavirus	NN
cord-350992-l6l24pco	274	82	229E	229e	CD
cord-350992-l6l24pco	274	83	infection	infection	NN
cord-350992-l6l24pco	274	84	in	in	IN
cord-350992-l6l24pco	274	85	human	human	JJ
cord-350992-l6l24pco	274	86	epithelial	epithelial	JJ
cord-350992-l6l24pco	274	87	lung	lung	NN
cord-350992-l6l24pco	274	88	cells	cell	NNS
cord-350992-l6l24pco	274	89	(	(	-LRB-
cord-350992-l6l24pco	274	90	L132	L132	NNP
cord-350992-l6l24pco	274	91	)	)	-RRB-
cord-350992-l6l24pco	274	92	by	by	IN
cord-350992-l6l24pco	274	93	chloroquine	chloroquine	NN
cord-350992-l6l24pco	274	94	:	:	:
cord-350992-l6l24pco	275	1	involvement	involvement	NN
cord-350992-l6l24pco	275	2	of	of	IN
cord-350992-l6l24pco	275	3	p38	p38	NNP
cord-350992-l6l24pco	275	4	MAPK	MAPK	NNP
cord-350992-l6l24pco	275	5	and	and	CC
cord-350992-l6l24pco	275	6	ERK	ERK	NNP
cord-350992-l6l24pco	275	7	Chloroquine	Chloroquine	NNP
cord-350992-l6l24pco	275	8	inhibits	inhibit	VBZ
cord-350992-l6l24pco	275	9	lytic	lytic	JJ
cord-350992-l6l24pco	275	10	replication	replication	NN
cord-350992-l6l24pco	275	11	of	of	IN
cord-350992-l6l24pco	275	12	Kaposi	Kaposi	NNP
cord-350992-l6l24pco	275	13	's	's	POS
cord-350992-l6l24pco	275	14	sarcoma	sarcoma	NN
cord-350992-l6l24pco	275	15	-	-	HYPH
cord-350992-l6l24pco	275	16	associated	associate	VBN
cord-350992-l6l24pco	275	17	herpesvirus	herpesvirus	NN
cord-350992-l6l24pco	275	18	by	by	IN
cord-350992-l6l24pco	275	19	disrupting	disrupt	VBG
cord-350992-l6l24pco	275	20	mTOR	mTOR	NNP
cord-350992-l6l24pco	275	21	and	and	CC
cord-350992-l6l24pco	275	22	p38-MAPK	p38-mapk	JJ
cord-350992-l6l24pco	275	23	activation	activation	NN
cord-350992-l6l24pco	275	24	Hydroxychloroquine	Hydroxychloroquine	NNP
cord-350992-l6l24pco	275	25	:	:	:
cord-350992-l6l24pco	275	26	from	from	IN
cord-350992-l6l24pco	275	27	malaria	malaria	NN
cord-350992-l6l24pco	275	28	to	to	IN
cord-350992-l6l24pco	276	1	autoimmunity	autoimmunity	NN
cord-350992-l6l24pco	276	2	Current	current	JJ
cord-350992-l6l24pco	276	3	and	and	CC
cord-350992-l6l24pco	276	4	Future	future	JJ
cord-350992-l6l24pco	276	5	Use	Use	NNP
cord-350992-l6l24pco	276	6	of	of	IN
cord-350992-l6l24pco	276	7	Chloroquine	Chloroquine	NNP
cord-350992-l6l24pco	276	8	and	and	CC
cord-350992-l6l24pco	276	9	Hydroxychloroquine	Hydroxychloroquine	NNP
cord-350992-l6l24pco	276	10	in	in	IN
cord-350992-l6l24pco	276	11	Infectious	Infectious	NNP
cord-350992-l6l24pco	276	12	,	,	,
cord-350992-l6l24pco	276	13	Immune	immune	JJ
cord-350992-l6l24pco	276	14	,	,	,
cord-350992-l6l24pco	276	15	Neoplastic	neoplastic	JJ
cord-350992-l6l24pco	276	16	,	,	,
cord-350992-l6l24pco	276	17	and	and	CC
cord-350992-l6l24pco	276	18	Neurological	Neurological	NNP
cord-350992-l6l24pco	276	19	Diseases	Diseases	NNPS
cord-350992-l6l24pco	276	20	:	:	:
cord-350992-l6l24pco	277	1	A	a	DT
cord-350992-l6l24pco	277	2	Mini	Mini	NNP
cord-350992-l6l24pco	277	3	-	-	NNP
cord-350992-l6l24pco	277	4	Review	review	NN
cord-350992-l6l24pco	278	1	The	the	DT
cord-350992-l6l24pco	278	2	ins	in	NNS
cord-350992-l6l24pco	278	3	and	and	CC
cord-350992-l6l24pco	278	4	outs	out	NNS
cord-350992-l6l24pco	278	5	of	of	IN
cord-350992-l6l24pco	278	6	MHC	MHC	NNP
cord-350992-l6l24pco	278	7	class	class	NN
cord-350992-l6l24pco	278	8	II	II	NNP
cord-350992-l6l24pco	278	9	-	-	HYPH
cord-350992-l6l24pco	278	10	mediated	mediate	VBN
cord-350992-l6l24pco	278	11	antigen	antigen	NN
cord-350992-l6l24pco	278	12	processing	processing	NN
cord-350992-l6l24pco	278	13	and	and	CC
cord-350992-l6l24pco	278	14	presentation	presentation	NN
cord-350992-l6l24pco	278	15	Macrophages	macrophage	NNS
cord-350992-l6l24pco	278	16	:	:	:
cord-350992-l6l24pco	278	17	Their	-PRON-	PRP$
cord-350992-l6l24pco	278	18	Untold	Untold	NNP
cord-350992-l6l24pco	278	19	Story	Story	NNP
cord-350992-l6l24pco	278	20	in	in	IN
cord-350992-l6l24pco	278	21	T	T	NNP
cord-350992-l6l24pco	278	22	Cell	Cell	NNP
cord-350992-l6l24pco	278	23	Activation	Activation	NNP
cord-350992-l6l24pco	278	24	and	and	CC
cord-350992-l6l24pco	278	25	Function	Function	NNP
cord-350992-l6l24pco	278	26	Hydroxychloroquine	Hydroxychloroquine	NNP
cord-350992-l6l24pco	278	27	Inhibits	inhibit	VBZ
cord-350992-l6l24pco	278	28	the	the	DT
cord-350992-l6l24pco	278	29	Differentiation	differentiation	NN
cord-350992-l6l24pco	278	30	of	of	IN
cord-350992-l6l24pco	279	1	Th17	Th17	NNP
cord-350992-l6l24pco	280	1	Cells	cell	NNS
cord-350992-l6l24pco	280	2	in	in	IN
cord-350992-l6l24pco	280	3	Systemic	Systemic	NNP
cord-350992-l6l24pco	280	4	Lupus	Lupus	NNP
cord-350992-l6l24pco	280	5	Erythematosus	Erythematosus	NNP
cord-350992-l6l24pco	280	6	Regulatory	regulatory	JJ
cord-350992-l6l24pco	280	7	molecules	molecule	NNS
cord-350992-l6l24pco	280	8	required	require	VBN
cord-350992-l6l24pco	280	9	for	for	IN
cord-350992-l6l24pco	280	10	nucleotide	nucleotide	NN
cord-350992-l6l24pco	280	11	-	-	HYPH
cord-350992-l6l24pco	280	12	sensing	sense	VBG
cord-350992-l6l24pco	280	13	Toll	toll	NN
cord-350992-l6l24pco	280	14	-	-	HYPH
cord-350992-l6l24pco	280	15	like	like	JJ
cord-350992-l6l24pco	280	16	receptors	receptor	NNS
cord-350992-l6l24pco	280	17	Activation	Activation	NNP
cord-350992-l6l24pco	280	18	of	of	IN
cord-350992-l6l24pco	280	19	toll	toll	NN
cord-350992-l6l24pco	280	20	-	-	HYPH
cord-350992-l6l24pco	280	21	like	like	JJ
cord-350992-l6l24pco	280	22	receptor-9	receptor-9	NNP
cord-350992-l6l24pco	280	23	induces	induce	VBZ
cord-350992-l6l24pco	280	24	matrix	matrix	NN
cord-350992-l6l24pco	280	25	metalloproteinase-9	metalloproteinase-9	NNP
cord-350992-l6l24pco	280	26	expression	expression	NN
cord-350992-l6l24pco	280	27	through	through	IN
cord-350992-l6l24pco	280	28	Akt	Akt	NNP
cord-350992-l6l24pco	280	29	and	and	CC
cord-350992-l6l24pco	280	30	tumor	tumor	NN
cord-350992-l6l24pco	280	31	necrosis	necrosis	NN
cord-350992-l6l24pco	280	32	factor	factor	NN
cord-350992-l6l24pco	280	33	-	-	HYPH
cord-350992-l6l24pco	280	34	alpha	alpha	NN
cord-350992-l6l24pco	280	35	signaling	signal	VBG
cord-350992-l6l24pco	280	36	Cationic	Cationic	NNP
cord-350992-l6l24pco	280	37	amphiphilic	amphiphilic	JJ
cord-350992-l6l24pco	280	38	drugs	drug	NNS
cord-350992-l6l24pco	280	39	and	and	CC
cord-350992-l6l24pco	280	40	platelet	platelet	NN
cord-350992-l6l24pco	280	41	phospholipase	phospholipase	NN
cord-350992-l6l24pco	280	42	A(2	A(2	NNP
cord-350992-l6l24pco	280	43	)	)	-RRB-
cord-350992-l6l24pco	281	1	(	(	-LRB-
cord-350992-l6l24pco	281	2	cPLA(2	cPLA(2	NNP
cord-350992-l6l24pco	281	3	)	)	-RRB-
cord-350992-l6l24pco	281	4	)	)	-RRB-
cord-350992-l6l24pco	282	1	The	the	DT
cord-350992-l6l24pco	282	2	Role	role	NN
cord-350992-l6l24pco	282	3	of	of	IN
cord-350992-l6l24pco	282	4	Cytokines	Cytokines	NNPS
cord-350992-l6l24pco	282	5	including	include	VBG
cord-350992-l6l24pco	282	6	Interleukin-6	Interleukin-6	NNP
cord-350992-l6l24pco	282	7	in	in	IN
cord-350992-l6l24pco	282	8	COVID-19	COVID-19	NNP
cord-350992-l6l24pco	282	9	induced	induce	VBN
cord-350992-l6l24pco	282	10	Pneumonia	Pneumonia	NNP
cord-350992-l6l24pco	282	11	and	and	CC
cord-350992-l6l24pco	282	12	Macrophage	Macrophage	NNP
cord-350992-l6l24pco	282	13	Activation	Activation	NNP
cord-350992-l6l24pco	282	14	Syndrome	Syndrome	NNP
cord-350992-l6l24pco	282	15	-	-	HYPH
cord-350992-l6l24pco	282	16	Like	like	JJ
cord-350992-l6l24pco	282	17	Disease	Disease	NNP
cord-350992-l6l24pco	283	1	The	the	DT
cord-350992-l6l24pco	283	2	versatile	versatile	JJ
cord-350992-l6l24pco	283	3	heparin	heparin	NN
cord-350992-l6l24pco	283	4	in	in	IN
cord-350992-l6l24pco	283	5	COVID-19	COVID-19	NNP
cord-350992-l6l24pco	283	6	Inhibition	Inhibition	NNP
cord-350992-l6l24pco	283	7	of	of	IN
cord-350992-l6l24pco	283	8	Cytosolic	Cytosolic	NNP
cord-350992-l6l24pco	283	9	Phospholipase	Phospholipase	NNP
cord-350992-l6l24pco	283	10	A(2)α	A(2)α	NNP
cord-350992-l6l24pco	283	11	Impairs	impair	VBZ
cord-350992-l6l24pco	283	12	an	an	DT
cord-350992-l6l24pco	283	13	Early	early	JJ
cord-350992-l6l24pco	283	14	Step	Step	NNP
cord-350992-l6l24pco	283	15	of	of	IN
cord-350992-l6l24pco	283	16	Coronavirus	Coronavirus	NNP
cord-350992-l6l24pco	283	17	Replication	Replication	NNP
cord-350992-l6l24pco	283	18	in	in	IN
cord-350992-l6l24pco	283	19	Cell	Cell	NNP
cord-350992-l6l24pco	283	20	Culture	culture	NN
cord-350992-l6l24pco	283	21	Clinical	clinical	JJ
cord-350992-l6l24pco	283	22	and	and	CC
cord-350992-l6l24pco	283	23	immunologic	immunologic	JJ
cord-350992-l6l24pco	283	24	features	feature	NNS
cord-350992-l6l24pco	283	25	in	in	IN
cord-350992-l6l24pco	283	26	severe	severe	JJ
cord-350992-l6l24pco	283	27	and	and	CC
cord-350992-l6l24pco	283	28	moderate	moderate	JJ
cord-350992-l6l24pco	283	29	Coronavirus	Coronavirus	NNP
cord-350992-l6l24pco	283	30	Disease	Disease	NNP
cord-350992-l6l24pco	283	31	How	how	WRB
cord-350992-l6l24pco	283	32	to	to	TO
cord-350992-l6l24pco	283	33	reduce	reduce	VB
cord-350992-l6l24pco	283	34	the	the	DT
cord-350992-l6l24pco	283	35	likelihood	likelihood	NN
cord-350992-l6l24pco	283	36	of	of	IN
cord-350992-l6l24pco	283	37	coronavirus-19	coronavirus-19	NNP
cord-350992-l6l24pco	283	38	(	(	-LRB-
cord-350992-l6l24pco	283	39	CoV-19	CoV-19	NNP
cord-350992-l6l24pco	283	40	or	or	CC
cord-350992-l6l24pco	283	41	SARS	SARS	NNP
cord-350992-l6l24pco	283	42	-	-	HYPH
cord-350992-l6l24pco	283	43	CoV-2	CoV-2	NNP
cord-350992-l6l24pco	283	44	)	)	-RRB-
cord-350992-l6l24pco	283	45	infection	infection	NN
cord-350992-l6l24pco	283	46	and	and	CC
cord-350992-l6l24pco	283	47	lung	lung	NN
cord-350992-l6l24pco	283	48	inflammation	inflammation	NN
cord-350992-l6l24pco	283	49	mediated	mediate	VBN
cord-350992-l6l24pco	283	50	by	by	IN
cord-350992-l6l24pco	283	51	IL-1	IL-1	NNP
cord-350992-l6l24pco	283	52	Selective	selective	JJ
cord-350992-l6l24pco	283	53	regulation	regulation	NN
cord-350992-l6l24pco	283	54	of	of	IN
cord-350992-l6l24pco	283	55	cytokine	cytokine	JJ
cord-350992-l6l24pco	283	56	secretion	secretion	NN
cord-350992-l6l24pco	283	57	by	by	IN
cord-350992-l6l24pco	283	58	hydroxychloroquine	hydroxychloroquine	NN
cord-350992-l6l24pco	283	59	:	:	:
cord-350992-l6l24pco	283	60	inhibition	inhibition	NN
cord-350992-l6l24pco	283	61	of	of	IN
cord-350992-l6l24pco	283	62	interleukin	interleukin	NN
cord-350992-l6l24pco	283	63	1	1	CD
cord-350992-l6l24pco	283	64	alpha	alpha	NN
cord-350992-l6l24pco	283	65	(	(	-LRB-
cord-350992-l6l24pco	283	66	IL-1-alpha	IL-1-alpha	''
cord-350992-l6l24pco	283	67	)	)	-RRB-
cord-350992-l6l24pco	283	68	and	and	CC
cord-350992-l6l24pco	283	69	IL-6	IL-6	NNP
cord-350992-l6l24pco	283	70	in	in	IN
cord-350992-l6l24pco	283	71	human	human	JJ
cord-350992-l6l24pco	283	72	monocytes	monocyte	NNS
cord-350992-l6l24pco	283	73	and	and	CC
cord-350992-l6l24pco	283	74	T	t	NN
cord-350992-l6l24pco	283	75	cells	cell	NNS
cord-350992-l6l24pco	284	1	Chloroquine	chloroquine	NN
cord-350992-l6l24pco	284	2	-	-	HYPH
cord-350992-l6l24pco	284	3	induced	induce	VBN
cord-350992-l6l24pco	284	4	inhibition	inhibition	NN
cord-350992-l6l24pco	284	5	of	of	IN
cord-350992-l6l24pco	284	6	the	the	DT
cord-350992-l6l24pco	284	7	production	production	NN
cord-350992-l6l24pco	284	8	of	of	IN
cord-350992-l6l24pco	284	9	TNF	TNF	NNP
cord-350992-l6l24pco	284	10	,	,	,
cord-350992-l6l24pco	284	11	but	but	CC
cord-350992-l6l24pco	284	12	not	not	RB
cord-350992-l6l24pco	284	13	of	of	IN
cord-350992-l6l24pco	284	14	IL-6	IL-6	NNP
cord-350992-l6l24pco	284	15	,	,	,
cord-350992-l6l24pco	284	16	is	be	VBZ
cord-350992-l6l24pco	284	17	affected	affect	VBN
cord-350992-l6l24pco	284	18	by	by	IN
cord-350992-l6l24pco	284	19	disruption	disruption	NN
cord-350992-l6l24pco	284	20	of	of	IN
cord-350992-l6l24pco	284	21	iron	iron	NN
cord-350992-l6l24pco	284	22	metabolism	metabolism	NN
cord-350992-l6l24pco	284	23	Chloroquine	Chloroquine	NNP
cord-350992-l6l24pco	284	24	and	and	CC
cord-350992-l6l24pco	284	25	hydroxychloroquine	hydroxychloroquine	NN
cord-350992-l6l24pco	284	26	equally	equally	RB
cord-350992-l6l24pco	284	27	affect	affect	VBP
cord-350992-l6l24pco	284	28	tumor	tumor	NN
cord-350992-l6l24pco	284	29	necrosis	necrosis	NN
cord-350992-l6l24pco	284	30	factor	factor	NN
cord-350992-l6l24pco	284	31	-	-	HYPH
cord-350992-l6l24pco	284	32	alpha	alpha	NN
cord-350992-l6l24pco	284	33	,	,	,
cord-350992-l6l24pco	284	34	interleukin	interleukin	NN
cord-350992-l6l24pco	284	35	6	6	CD
cord-350992-l6l24pco	284	36	,	,	,
cord-350992-l6l24pco	284	37	and	and	CC
cord-350992-l6l24pco	284	38	interferongamma	interferongamma	JJ
cord-350992-l6l24pco	284	39	production	production	NN
cord-350992-l6l24pco	284	40	by	by	IN
cord-350992-l6l24pco	284	41	peripheral	peripheral	JJ
cord-350992-l6l24pco	284	42	blood	blood	NN
cord-350992-l6l24pco	284	43	mononuclear	mononuclear	NN
cord-350992-l6l24pco	284	44	cells	cell	NNS
cord-350992-l6l24pco	285	1	Chloroquine	Chloroquine	NNP
cord-350992-l6l24pco	285	2	inhibits	inhibit	VBZ
cord-350992-l6l24pco	285	3	processing	processing	NN
cord-350992-l6l24pco	285	4	of	of	IN
cord-350992-l6l24pco	285	5	tumor	tumor	NN
cord-350992-l6l24pco	285	6	necrosis	necrosis	NN
cord-350992-l6l24pco	285	7	factor	factor	NN
cord-350992-l6l24pco	285	8	in	in	IN
cord-350992-l6l24pco	285	9	lipopolysaccharidestimulated	lipopolysaccharidestimulate	VBN
cord-350992-l6l24pco	285	10	RAW	raw	JJ
cord-350992-l6l24pco	285	11	264.7	264.7	CD
cord-350992-l6l24pco	285	12	macrophages	macrophage	NNS
cord-350992-l6l24pco	286	1	The	the	DT
cord-350992-l6l24pco	286	2	potential	potential	JJ
cord-350992-l6l24pco	286	3	place	place	NN
cord-350992-l6l24pco	286	4	of	of	IN
cord-350992-l6l24pco	286	5	chloroquine	chloroquine	NN
cord-350992-l6l24pco	286	6	in	in	IN
cord-350992-l6l24pco	286	7	the	the	DT
cord-350992-l6l24pco	286	8	treatment	treatment	NN
cord-350992-l6l24pco	286	9	of	of	IN
cord-350992-l6l24pco	286	10	HIV-1-infected	hiv-1-infecte	VBN
cord-350992-l6l24pco	286	11	patients	patient	NNS
cord-350992-l6l24pco	286	12	Gold	Gold	NNP
cord-350992-l6l24pco	286	13	sodium	sodium	NN
cord-350992-l6l24pco	286	14	thiomalate	thiomalate	NN
cord-350992-l6l24pco	286	15	and	and	CC
cord-350992-l6l24pco	286	16	chloroquine	chloroquine	NN
cord-350992-l6l24pco	286	17	inhibit	inhibit	VB
cord-350992-l6l24pco	286	18	cytokine	cytokine	JJ
cord-350992-l6l24pco	286	19	production	production	NN
cord-350992-l6l24pco	286	20	in	in	IN
cord-350992-l6l24pco	286	21	monocytic	monocytic	NNP
cord-350992-l6l24pco	286	22	THP-1	THP-1	NNP
cord-350992-l6l24pco	286	23	cells	cell	NNS
cord-350992-l6l24pco	286	24	through	through	IN
cord-350992-l6l24pco	286	25	distinct	distinct	JJ
cord-350992-l6l24pco	286	26	transcriptional	transcriptional	JJ
cord-350992-l6l24pco	286	27	and	and	CC
cord-350992-l6l24pco	286	28	posttranslational	posttranslational	JJ
cord-350992-l6l24pco	286	29	mechanisms	mechanism	NNS
cord-350992-l6l24pco	287	1	Chloroquine	Chloroquine	NNP
cord-350992-l6l24pco	287	2	protects	protect	VBZ
cord-350992-l6l24pco	287	3	mice	mouse	NNS
cord-350992-l6l24pco	287	4	from	from	IN
cord-350992-l6l24pco	287	5	challenge	challenge	NN
cord-350992-l6l24pco	287	6	with	with	IN
cord-350992-l6l24pco	287	7	CpG	CpG	NNP
cord-350992-l6l24pco	287	8	ODN	ODN	NNP
cord-350992-l6l24pco	287	9	and	and	CC
cord-350992-l6l24pco	287	10	LPS	LPS	NNP
cord-350992-l6l24pco	287	11	by	by	IN
cord-350992-l6l24pco	287	12	decreasing	decrease	VBG
cord-350992-l6l24pco	287	13	proinflammatory	proinflammatory	JJ
cord-350992-l6l24pco	287	14	cytokine	cytokine	NN
cord-350992-l6l24pco	287	15	release	release	NN
cord-350992-l6l24pco	288	1	Chloroquine	Chloroquine	NNP
cord-350992-l6l24pco	288	2	inhibits	inhibit	VBZ
cord-350992-l6l24pco	288	3	production	production	NN
cord-350992-l6l24pco	288	4	of	of	IN
cord-350992-l6l24pco	288	5	TNF	tnf	NN
cord-350992-l6l24pco	288	6	-	-	HYPH
cord-350992-l6l24pco	288	7	alpha	alpha	NN
cord-350992-l6l24pco	288	8	,	,	,
cord-350992-l6l24pco	288	9	IL-1beta	il-1beta	NN
cord-350992-l6l24pco	288	10	and	and	CC
cord-350992-l6l24pco	288	11	IL-6	IL-6	NNP
cord-350992-l6l24pco	288	12	from	from	IN
cord-350992-l6l24pco	289	1	lipopolysaccharide	lipopolysaccharide	NN
cord-350992-l6l24pco	289	2	-	-	HYPH
cord-350992-l6l24pco	289	3	stimulated	stimulate	VBN
cord-350992-l6l24pco	289	4	human	human	JJ
cord-350992-l6l24pco	289	5	monocytes	monocyte	NNS
cord-350992-l6l24pco	289	6	/	/	SYM
cord-350992-l6l24pco	289	7	macrophages	macrophage	NNS
cord-350992-l6l24pco	289	8	by	by	IN
cord-350992-l6l24pco	289	9	different	different	JJ
cord-350992-l6l24pco	289	10	modes	mode	NNS
cord-350992-l6l24pco	290	1	Chloroquine	Chloroquine	NNP
cord-350992-l6l24pco	290	2	interferes	interfere	VBZ
cord-350992-l6l24pco	290	3	with	with	IN
cord-350992-l6l24pco	290	4	dengue-2	dengue-2	NNP
cord-350992-l6l24pco	290	5	virus	virus	NN
cord-350992-l6l24pco	290	6	replication	replication	NN
cord-350992-l6l24pco	290	7	in	in	IN
cord-350992-l6l24pco	290	8	U937	U937	NNP
cord-350992-l6l24pco	290	9	cells	cell	NNS
cord-350992-l6l24pco	290	10	Antibody	antibody	NN
cord-350992-l6l24pco	290	11	-	-	HYPH
cord-350992-l6l24pco	290	12	dependent	dependent	JJ
cord-350992-l6l24pco	290	13	SARS	SARS	NNP
cord-350992-l6l24pco	290	14	coronavirus	coronavirus	NN
cord-350992-l6l24pco	290	15	infection	infection	NN
cord-350992-l6l24pco	290	16	is	be	VBZ
cord-350992-l6l24pco	290	17	mediated	mediate	VBN
cord-350992-l6l24pco	290	18	by	by	IN
cord-350992-l6l24pco	290	19	antibodies	antibody	NNS
cord-350992-l6l24pco	290	20	against	against	IN
cord-350992-l6l24pco	290	21	spike	spike	NN
cord-350992-l6l24pco	290	22	proteins	protein	NNS
cord-350992-l6l24pco	290	23	Pulmonary	pulmonary	JJ
cord-350992-l6l24pco	290	24	embolism	embolism	NN
cord-350992-l6l24pco	290	25	and	and	CC
cord-350992-l6l24pco	290	26	its	-PRON-	PRP$
cord-350992-l6l24pco	290	27	prophylaxis	prophylaxis	NN
cord-350992-l6l24pco	290	28	following	follow	VBG
cord-350992-l6l24pco	290	29	the	the	DT
cord-350992-l6l24pco	290	30	Charnley	Charnley	NNP
cord-350992-l6l24pco	290	31	total	total	JJ
cord-350992-l6l24pco	290	32	hip	hip	NN
cord-350992-l6l24pco	290	33	replacement	replacement	NN
cord-350992-l6l24pco	290	34	Hydroxychloroquine	Hydroxychloroquine	NNP
cord-350992-l6l24pco	290	35	in	in	IN
cord-350992-l6l24pco	290	36	prophylaxis	prophylaxis	NN
cord-350992-l6l24pco	290	37	of	of	IN
cord-350992-l6l24pco	290	38	pulmonary	pulmonary	JJ
cord-350992-l6l24pco	290	39	embolism	embolism	NN
cord-350992-l6l24pco	290	40	following	follow	VBG
cord-350992-l6l24pco	290	41	hip	hip	NN
cord-350992-l6l24pco	290	42	arthroplasty	arthroplasty	NNP
cord-350992-l6l24pco	290	43	Hydroxychloroquine	Hydroxychloroquine	NNP
cord-350992-l6l24pco	290	44	as	as	IN
cord-350992-l6l24pco	290	45	an	an	DT
cord-350992-l6l24pco	290	46	anti	anti	JJ
cord-350992-l6l24pco	290	47	-	-	JJ
cord-350992-l6l24pco	290	48	thrombotic	thrombotic	JJ
cord-350992-l6l24pco	290	49	in	in	IN
cord-350992-l6l24pco	290	50	antiphospholipid	antiphospholipid	NNP
cord-350992-l6l24pco	290	51	syndrome	syndrome	NN
cord-350992-l6l24pco	290	52	Effect	Effect	NNP
cord-350992-l6l24pco	290	53	of	of	IN
cord-350992-l6l24pco	290	54	antimalarials	antimalarial	NNS
cord-350992-l6l24pco	290	55	on	on	IN
cord-350992-l6l24pco	290	56	thrombosis	thrombosis	NN
cord-350992-l6l24pco	290	57	and	and	CC
cord-350992-l6l24pco	290	58	survival	survival	NN
cord-350992-l6l24pco	290	59	in	in	IN
cord-350992-l6l24pco	290	60	patients	patient	NNS
cord-350992-l6l24pco	290	61	with	with	IN
cord-350992-l6l24pco	290	62	systemic	systemic	JJ
cord-350992-l6l24pco	290	63	lupus	lupus	NN
cord-350992-l6l24pco	290	64	erythematosus	erythematosus	NN
cord-350992-l6l24pco	290	65	Risk	risk	NN
cord-350992-l6l24pco	290	66	and	and	CC
cord-350992-l6l24pco	290	67	protective	protective	JJ
cord-350992-l6l24pco	290	68	factors	factor	NNS
cord-350992-l6l24pco	290	69	for	for	IN
cord-350992-l6l24pco	290	70	thrombosis	thrombosis	NN
cord-350992-l6l24pco	290	71	in	in	IN
cord-350992-l6l24pco	290	72	systemic	systemic	JJ
cord-350992-l6l24pco	290	73	lupus	lupus	NN
cord-350992-l6l24pco	290	74	erythematosus	erythematosus	NN
cord-350992-l6l24pco	290	75	:	:	:
cord-350992-l6l24pco	290	76	results	result	NNS
cord-350992-l6l24pco	290	77	from	from	IN
cord-350992-l6l24pco	290	78	a	a	DT
cord-350992-l6l24pco	290	79	large	large	JJ
cord-350992-l6l24pco	290	80	,	,	,
cord-350992-l6l24pco	290	81	multi	multi	JJ
cord-350992-l6l24pco	290	82	-	-	JJ
cord-350992-l6l24pco	290	83	ethnic	ethnic	JJ
cord-350992-l6l24pco	290	84	cohort	cohort	NN
cord-350992-l6l24pco	290	85	Risk	risk	NN
cord-350992-l6l24pco	290	86	factors	factor	NNS
cord-350992-l6l24pco	290	87	for	for	IN
cord-350992-l6l24pco	290	88	thrombosis	thrombosis	NN
cord-350992-l6l24pco	290	89	and	and	CC
cord-350992-l6l24pco	290	90	primary	primary	JJ
cord-350992-l6l24pco	290	91	thrombosis	thrombosis	NN
cord-350992-l6l24pco	290	92	prevention	prevention	NN
cord-350992-l6l24pco	290	93	in	in	IN
cord-350992-l6l24pco	290	94	patients	patient	NNS
cord-350992-l6l24pco	290	95	with	with	IN
cord-350992-l6l24pco	290	96	systemic	systemic	JJ
cord-350992-l6l24pco	290	97	lupus	lupus	NN
cord-350992-l6l24pco	290	98	erythematosus	erythematosu	VBG
cord-350992-l6l24pco	290	99	with	with	IN
cord-350992-l6l24pco	290	100	or	or	CC
cord-350992-l6l24pco	290	101	without	without	IN
cord-350992-l6l24pco	290	102	antiphospholipid	antiphospholipid	NN
cord-350992-l6l24pco	290	103	antibodies	antibody	NNS
cord-350992-l6l24pco	290	104	Use	Use	NNP
cord-350992-l6l24pco	290	105	of	of	IN
cord-350992-l6l24pco	290	106	hydroxychloroquine	hydroxychloroquine	NN
cord-350992-l6l24pco	290	107	to	to	TO
cord-350992-l6l24pco	290	108	prevent	prevent	VB
cord-350992-l6l24pco	290	109	thrombosis	thrombosis	NN
cord-350992-l6l24pco	290	110	in	in	IN
cord-350992-l6l24pco	290	111	systemic	systemic	JJ
cord-350992-l6l24pco	290	112	lupus	lupus	NN
cord-350992-l6l24pco	290	113	erythematosus	erythematosus	NN
cord-350992-l6l24pco	290	114	and	and	CC
cord-350992-l6l24pco	290	115	in	in	IN
cord-350992-l6l24pco	290	116	antiphospholipid	antiphospholipid	JJ
cord-350992-l6l24pco	290	117	antibody	antibody	NN
cord-350992-l6l24pco	290	118	-	-	HYPH
cord-350992-l6l24pco	290	119	positive	positive	JJ
cord-350992-l6l24pco	290	120	patients	patient	NNS
cord-350992-l6l24pco	290	121	Systemic	systemic	JJ
cord-350992-l6l24pco	290	122	lupus	lupus	NN
cord-350992-l6l24pco	290	123	erythematosus	erythematosus	NN
cord-350992-l6l24pco	290	124	in	in	IN
cord-350992-l6l24pco	290	125	a	a	DT
cord-350992-l6l24pco	290	126	multiethnic	multiethnic	JJ
cord-350992-l6l24pco	290	127	cohort	cohort	NN
cord-350992-l6l24pco	290	128	(	(	-LRB-
cord-350992-l6l24pco	290	129	LUMINA	LUMINA	NNP
cord-350992-l6l24pco	290	130	)	)	-RRB-
cord-350992-l6l24pco	290	131	:	:	:
cord-350992-l6l24pco	290	132	XXVIII	XXVIII	NNP
cord-350992-l6l24pco	290	133	.	.	.
cord-350992-l6l24pco	291	1	Factors	factor	NNS
cord-350992-l6l24pco	291	2	predictive	predictive	JJ
cord-350992-l6l24pco	291	3	of	of	IN
cord-350992-l6l24pco	291	4	thrombotic	thrombotic	JJ
cord-350992-l6l24pco	291	5	events	event	NNS
cord-350992-l6l24pco	291	6	Hydroxychloroquine	Hydroxychloroquine	NNP
cord-350992-l6l24pco	291	7	use	use	NN
cord-350992-l6l24pco	291	8	is	be	VBZ
cord-350992-l6l24pco	291	9	associated	associate	VBN
cord-350992-l6l24pco	291	10	with	with	IN
cord-350992-l6l24pco	291	11	lower	low	JJR
cord-350992-l6l24pco	291	12	odds	odd	NNS
cord-350992-l6l24pco	291	13	of	of	IN
cord-350992-l6l24pco	291	14	persistently	persistently	RB
cord-350992-l6l24pco	291	15	positive	positive	JJ
cord-350992-l6l24pco	291	16	antiphospholipid	antiphospholipid	NN
cord-350992-l6l24pco	291	17	antibodies	antibody	NNS
cord-350992-l6l24pco	291	18	and/or	and/or	CC
cord-350992-l6l24pco	291	19	lupus	lupus	NN
cord-350992-l6l24pco	291	20	anticoagulant	anticoagulant	JJ
cord-350992-l6l24pco	291	21	in	in	IN
cord-350992-l6l24pco	291	22	systemic	systemic	JJ
cord-350992-l6l24pco	291	23	lupus	lupus	NN
cord-350992-l6l24pco	292	1	erythematosus	erythematosus	NN
cord-350992-l6l24pco	292	2	Long	long	JJ
cord-350992-l6l24pco	292	3	-	-	HYPH
cord-350992-l6l24pco	292	4	term	term	NN
cord-350992-l6l24pco	292	5	use	use	NN
cord-350992-l6l24pco	292	6	of	of	IN
cord-350992-l6l24pco	292	7	hydroxychloroquine	hydroxychloroquine	NNP
cord-350992-l6l24pco	292	8	reduces	reduce	VBZ
cord-350992-l6l24pco	292	9	antiphospholipid	antiphospholipid	NNP
cord-350992-l6l24pco	292	10	antibodies	antibody	NNS
cord-350992-l6l24pco	292	11	levels	level	NNS
cord-350992-l6l24pco	292	12	in	in	IN
cord-350992-l6l24pco	292	13	patients	patient	NNS
cord-350992-l6l24pco	292	14	with	with	IN
cord-350992-l6l24pco	292	15	primary	primary	JJ
cord-350992-l6l24pco	292	16	antiphospholipid	antiphospholipid	NNP
cord-350992-l6l24pco	292	17	syndrome	syndrome	NN
cord-350992-l6l24pco	293	1	The	the	DT
cord-350992-l6l24pco	293	2	effect	effect	NN
cord-350992-l6l24pco	293	3	of	of	IN
cord-350992-l6l24pco	293	4	hydroxychloroquine	hydroxychloroquine	NN
cord-350992-l6l24pco	293	5	on	on	IN
cord-350992-l6l24pco	293	6	thrombosis	thrombosis	NN
cord-350992-l6l24pco	293	7	prevention	prevention	NNP
cord-350992-l6l24pco	293	8	and	and	CC
cord-350992-l6l24pco	293	9	antiphospholipid	antiphospholipid	NNP
cord-350992-l6l24pco	293	10	antibody	antibody	NN
cord-350992-l6l24pco	293	11	levels	level	NNS
cord-350992-l6l24pco	293	12	in	in	IN
cord-350992-l6l24pco	293	13	primary	primary	JJ
cord-350992-l6l24pco	293	14	antiphospholipid	antiphospholipid	NNP
cord-350992-l6l24pco	293	15	syndrome	syndrome	NN
cord-350992-l6l24pco	293	16	:	:	:
cord-350992-l6l24pco	293	17	A	a	DT
cord-350992-l6l24pco	293	18	pilot	pilot	NN
cord-350992-l6l24pco	293	19	open	open	JJ
cord-350992-l6l24pco	293	20	label	label	NN
cord-350992-l6l24pco	293	21	randomized	randomized	JJ
cord-350992-l6l24pco	293	22	prospective	prospective	JJ
cord-350992-l6l24pco	293	23	study	study	NN
cord-350992-l6l24pco	293	24	Emerging	emerge	VBG
cord-350992-l6l24pco	293	25	therapies	therapy	NNS
cord-350992-l6l24pco	293	26	in	in	IN
cord-350992-l6l24pco	293	27	antiphospholipid	antiphospholipid	NNP
cord-350992-l6l24pco	293	28	syndrome	syndrome	NN
cord-350992-l6l24pco	294	1	Will	Will	MD
cord-350992-l6l24pco	294	2	Complement	complement	VB
cord-350992-l6l24pco	294	3	Inhibition	inhibition	NN
cord-350992-l6l24pco	294	4	be	be	VB
cord-350992-l6l24pco	294	5	the	the	DT
cord-350992-l6l24pco	294	6	New	New	NNP
cord-350992-l6l24pco	294	7	Target	Target	NNP
cord-350992-l6l24pco	294	8	in	in	IN
cord-350992-l6l24pco	294	9	Treating	treat	VBG
cord-350992-l6l24pco	294	10	COVID-19	COVID-19	NNP
cord-350992-l6l24pco	294	11	Related	related	JJ
cord-350992-l6l24pco	294	12	Systemic	Systemic	NNP
cord-350992-l6l24pco	294	13	Thrombosis	Thrombosis	NNP
cord-350992-l6l24pco	294	14	?	?	.
cord-350992-l6l24pco	295	1	Circulation	circulation	NN
cord-350992-l6l24pco	295	2	Antiaggregation	Antiaggregation	NNP
cord-350992-l6l24pco	295	3	action	action	NN
cord-350992-l6l24pco	295	4	of	of	IN
cord-350992-l6l24pco	295	5	chloroquine	chloroquine	NNP
cord-350992-l6l24pco	295	6	Prevention	Prevention	NNP
cord-350992-l6l24pco	295	7	of	of	IN
cord-350992-l6l24pco	295	8	the	the	DT
cord-350992-l6l24pco	295	9	platelet	platelet	NN
cord-350992-l6l24pco	295	10	alpha	alpha	NN
cord-350992-l6l24pco	295	11	-	-	HYPH
cord-350992-l6l24pco	295	12	granule	granule	NN
cord-350992-l6l24pco	295	13	release	release	NN
cord-350992-l6l24pco	295	14	reaction	reaction	NN
cord-350992-l6l24pco	295	15	by	by	IN
cord-350992-l6l24pco	295	16	membrane	membrane	NN
cord-350992-l6l24pco	295	17	-	-	HYPH
cord-350992-l6l24pco	295	18	active	active	JJ
cord-350992-l6l24pco	295	19	drugs	drug	NNS
cord-350992-l6l24pco	296	1	On	on	IN
cord-350992-l6l24pco	296	2	the	the	DT
cord-350992-l6l24pco	296	3	inhibitory	inhibitory	JJ
cord-350992-l6l24pco	296	4	effect	effect	NN
cord-350992-l6l24pco	296	5	of	of	IN
cord-350992-l6l24pco	296	6	chloroquine	chloroquine	NN
cord-350992-l6l24pco	296	7	on	on	IN
cord-350992-l6l24pco	296	8	blood	blood	NN
cord-350992-l6l24pco	296	9	platelet	platelet	NN
cord-350992-l6l24pco	296	10	aggregation	aggregation	NN
cord-350992-l6l24pco	297	1	Hydroxychloroquine	Hydroxychloroquine	NNP
cord-350992-l6l24pco	297	2	reverses	reverse	VBZ
cord-350992-l6l24pco	297	3	platelet	platelet	NN
cord-350992-l6l24pco	297	4	activation	activation	NN
cord-350992-l6l24pco	297	5	induced	induce	VBN
cord-350992-l6l24pco	297	6	by	by	IN
cord-350992-l6l24pco	297	7	human	human	JJ
cord-350992-l6l24pco	297	8	IgG	IgG	NNP
cord-350992-l6l24pco	297	9	antiphospholipid	antiphospholipid	NNP
cord-350992-l6l24pco	297	10	antibodies	antibodies	NNP
cord-350992-l6l24pco	297	11	Modification	Modification	NNP
cord-350992-l6l24pco	297	12	of	of	IN
cord-350992-l6l24pco	297	13	transoperative	transoperative	NN
cord-350992-l6l24pco	297	14	changes	change	NNS
cord-350992-l6l24pco	297	15	in	in	IN
cord-350992-l6l24pco	297	16	blood	blood	NN
cord-350992-l6l24pco	297	17	fluidity	fluidity	NN
cord-350992-l6l24pco	297	18	by	by	IN
cord-350992-l6l24pco	297	19	hydroxychloroquine	hydroxychloroquine	NN
cord-350992-l6l24pco	297	20	:	:	:
cord-350992-l6l24pco	298	1	a	a	DT
cord-350992-l6l24pco	298	2	possible	possible	JJ
cord-350992-l6l24pco	298	3	explanation	explanation	NN
cord-350992-l6l24pco	298	4	for	for	IN
cord-350992-l6l24pco	298	5	the	the	DT
cord-350992-l6l24pco	298	6	drug	drug	NN
cord-350992-l6l24pco	298	7	's	's	POS
cord-350992-l6l24pco	298	8	antithrombotic	antithrombotic	JJ
cord-350992-l6l24pco	298	9	effect	effect	NN
cord-350992-l6l24pco	298	10	Some	some	DT
cord-350992-l6l24pco	298	11	rheological	rheological	JJ
cord-350992-l6l24pco	298	12	properties	property	NNS
cord-350992-l6l24pco	298	13	of	of	IN
cord-350992-l6l24pco	298	14	blood	blood	NN
cord-350992-l6l24pco	298	15	during	during	IN
cord-350992-l6l24pco	298	16	antirheumatoid	antirheumatoid	NNP
cord-350992-l6l24pco	298	17	therapy	therapy	NN
cord-350992-l6l24pco	298	18	Beneficial	beneficial	JJ
cord-350992-l6l24pco	298	19	suicide	suicide	NN
cord-350992-l6l24pco	298	20	:	:	:
cord-350992-l6l24pco	298	21	why	why	WRB
cord-350992-l6l24pco	298	22	neutrophils	neutrophil	NNS
cord-350992-l6l24pco	298	23	die	die	VBP
cord-350992-l6l24pco	298	24	to	to	TO
cord-350992-l6l24pco	298	25	make	make	VB
cord-350992-l6l24pco	298	26	NETs	net	NNS
cord-350992-l6l24pco	299	1	In	in	IN
cord-350992-l6l24pco	299	2	vivo	vivo	NN
cord-350992-l6l24pco	299	3	role	role	NN
cord-350992-l6l24pco	299	4	of	of	IN
cord-350992-l6l24pco	299	5	neutrophil	neutrophil	NN
cord-350992-l6l24pco	299	6	extracellular	extracellular	JJ
cord-350992-l6l24pco	299	7	traps	trap	NNS
cord-350992-l6l24pco	299	8	in	in	IN
cord-350992-l6l24pco	299	9	antiphospholipid	antiphospholipid	NNP
cord-350992-l6l24pco	299	10	antibody	antibody	NN
cord-350992-l6l24pco	299	11	-	-	HYPH
cord-350992-l6l24pco	299	12	mediated	mediate	VBN
cord-350992-l6l24pco	299	13	venous	venous	JJ
cord-350992-l6l24pco	299	14	thrombosis	thrombosis	NN
cord-350992-l6l24pco	299	15	Harnessing	harness	VBG
cord-350992-l6l24pco	299	16	Innate	innate	JJ
cord-350992-l6l24pco	299	17	Immunity	Immunity	NNP
cord-350992-l6l24pco	299	18	to	to	TO
cord-350992-l6l24pco	299	19	Eliminate	eliminate	VB
cord-350992-l6l24pco	299	20	SARS	SARS	NNP
cord-350992-l6l24pco	299	21	-	-	HYPH
cord-350992-l6l24pco	299	22	CoV-2	CoV-2	NNP
cord-350992-l6l24pco	299	23	and	and	CC
cord-350992-l6l24pco	299	24	Ameliorate	ameliorate	VB
cord-350992-l6l24pco	299	25	COVID-19	COVID-19	NNP
cord-350992-l6l24pco	299	26	Disease	Disease	NNP
cord-350992-l6l24pco	299	27	Chloroquine	Chloroquine	NNP
cord-350992-l6l24pco	299	28	reduces	reduce	VBZ
cord-350992-l6l24pco	299	29	hypercoagulability	hypercoagulability	NN
cord-350992-l6l24pco	299	30	in	in	IN
cord-350992-l6l24pco	299	31	pancreatic	pancreatic	JJ
cord-350992-l6l24pco	299	32	cancer	cancer	NN
cord-350992-l6l24pco	299	33	through	through	IN
cord-350992-l6l24pco	299	34	inhibition	inhibition	NN
cord-350992-l6l24pco	299	35	of	of	IN
cord-350992-l6l24pco	299	36	neutrophil	neutrophil	NN
cord-350992-l6l24pco	299	37	extracellular	extracellular	JJ
cord-350992-l6l24pco	299	38	traps	trap	NNS
cord-350992-l6l24pco	300	1	Hydroxychloroquine	Hydroxychloroquine	NNP
cord-350992-l6l24pco	300	2	directly	directly	RB
cord-350992-l6l24pco	300	3	reduces	reduce	VBZ
cord-350992-l6l24pco	300	4	the	the	DT
cord-350992-l6l24pco	300	5	binding	binding	NN
cord-350992-l6l24pco	300	6	of	of	IN
cord-350992-l6l24pco	300	7	antiphospholipid	antiphospholipid	NNP
cord-350992-l6l24pco	300	8	antibody	antibody	NN
cord-350992-l6l24pco	300	9	-	-	HYPH
cord-350992-l6l24pco	300	10	beta2-glycoprotein	beta2-glycoprotein	NNP
cord-350992-l6l24pco	300	11	I	i	NN
cord-350992-l6l24pco	300	12	complexes	complex	NNS
cord-350992-l6l24pco	300	13	to	to	IN
cord-350992-l6l24pco	300	14	phospholipid	phospholipid	NN
cord-350992-l6l24pco	300	15	bilayers	bilayer	NNS
cord-350992-l6l24pco	300	16	Clustering	cluster	VBG
cord-350992-l6l24pco	300	17	of	of	IN
cord-350992-l6l24pco	300	18	lipid	lipid	NN
cord-350992-l6l24pco	300	19	-	-	HYPH
cord-350992-l6l24pco	300	20	bound	bind	VBN
cord-350992-l6l24pco	300	21	annexin	annexin	NN
cord-350992-l6l24pco	300	22	V	v	NN
cord-350992-l6l24pco	301	1	may	may	MD
cord-350992-l6l24pco	301	2	explain	explain	VB
cord-350992-l6l24pco	301	3	its	-PRON-	PRP$
cord-350992-l6l24pco	301	4	anticoagulant	anticoagulant	JJ
cord-350992-l6l24pco	301	5	effect	effect	NN
cord-350992-l6l24pco	302	1	Hydroxychloroquine	Hydroxychloroquine	NNP
cord-350992-l6l24pco	302	2	protects	protect	VBZ
cord-350992-l6l24pco	302	3	the	the	DT
cord-350992-l6l24pco	302	4	annexin	annexin	JJ
cord-350992-l6l24pco	302	5	A5	A5	NNP
cord-350992-l6l24pco	302	6	anticoagulant	anticoagulant	JJ
cord-350992-l6l24pco	302	7	shield	shield	NN
cord-350992-l6l24pco	302	8	from	from	IN
cord-350992-l6l24pco	302	9	disruption	disruption	NN
cord-350992-l6l24pco	302	10	by	by	IN
cord-350992-l6l24pco	302	11	antiphospholipid	antiphospholipid	NNP
cord-350992-l6l24pco	302	12	antibodies	antibody	NNS
cord-350992-l6l24pco	302	13	:	:	:
cord-350992-l6l24pco	302	14	evidence	evidence	NN
cord-350992-l6l24pco	302	15	for	for	IN
cord-350992-l6l24pco	302	16	a	a	DT
cord-350992-l6l24pco	302	17	novel	novel	JJ
cord-350992-l6l24pco	302	18	effect	effect	NN
cord-350992-l6l24pco	302	19	for	for	IN
cord-350992-l6l24pco	302	20	an	an	DT
cord-350992-l6l24pco	302	21	old	old	JJ
cord-350992-l6l24pco	302	22	antimalarial	antimalarial	JJ
cord-350992-l6l24pco	302	23	drug	drug	NN
cord-350992-l6l24pco	302	24	The	the	DT
cord-350992-l6l24pco	302	25	annexin	annexin	JJ
cord-350992-l6l24pco	302	26	A5-mediated	a5-mediate	VBD
cord-350992-l6l24pco	302	27	pathogenic	pathogenic	JJ
cord-350992-l6l24pco	302	28	mechanism	mechanism	NN
cord-350992-l6l24pco	302	29	in	in	IN
cord-350992-l6l24pco	302	30	the	the	DT
cord-350992-l6l24pco	302	31	antiphospholipid	antiphospholipid	NNP
cord-350992-l6l24pco	302	32	syndrome	syndrome	NN
cord-350992-l6l24pco	302	33	:	:	:
cord-350992-l6l24pco	302	34	role	role	NN
cord-350992-l6l24pco	302	35	in	in	IN
cord-350992-l6l24pco	302	36	pregnancy	pregnancy	NN
cord-350992-l6l24pco	302	37	losses	loss	NNS
cord-350992-l6l24pco	302	38	and	and	CC
cord-350992-l6l24pco	302	39	thrombosis	thrombosis	NN
cord-350992-l6l24pco	302	40	Hydroxychloroquine	Hydroxychloroquine	NNP
cord-350992-l6l24pco	302	41	partially	partially	RB
cord-350992-l6l24pco	302	42	prevents	prevent	VBZ
cord-350992-l6l24pco	302	43	endothelial	endothelial	JJ
cord-350992-l6l24pco	302	44	dysfunction	dysfunction	NN
cord-350992-l6l24pco	302	45	induced	induce	VBN
cord-350992-l6l24pco	302	46	by	by	IN
cord-350992-l6l24pco	302	47	anti	anti	JJ
cord-350992-l6l24pco	302	48	-	-	JJ
cord-350992-l6l24pco	302	49	beta-2-GPI	beta-2-gpi	JJ
cord-350992-l6l24pco	302	50	antibodies	antibody	NNS
cord-350992-l6l24pco	302	51	in	in	IN
cord-350992-l6l24pco	302	52	an	an	DT
cord-350992-l6l24pco	302	53	in	in	IN
cord-350992-l6l24pco	302	54	vivo	vivo	NN
cord-350992-l6l24pco	302	55	mouse	mouse	NN
cord-350992-l6l24pco	302	56	model	model	NN
cord-350992-l6l24pco	302	57	of	of	IN
cord-350992-l6l24pco	303	1	antiphospholipid	antiphospholipid	NNP
cord-350992-l6l24pco	303	2	syndrome	syndrome	NN
cord-350992-l6l24pco	303	3	Hydroxychloroquine	Hydroxychloroquine	NNP
cord-350992-l6l24pco	303	4	reverses	reverse	VBZ
cord-350992-l6l24pco	303	5	the	the	DT
cord-350992-l6l24pco	303	6	prothrombotic	prothrombotic	JJ
cord-350992-l6l24pco	303	7	state	state	NN
cord-350992-l6l24pco	303	8	in	in	IN
cord-350992-l6l24pco	303	9	a	a	DT
cord-350992-l6l24pco	303	10	mouse	mouse	NN
cord-350992-l6l24pco	303	11	model	model	NN
cord-350992-l6l24pco	303	12	of	of	IN
cord-350992-l6l24pco	303	13	antiphospholipid	antiphospholipid	NNP
cord-350992-l6l24pco	303	14	syndrome	syndrome	NN
cord-350992-l6l24pco	303	15	:	:	:
cord-350992-l6l24pco	303	16	Role	role	NN
cord-350992-l6l24pco	303	17	of	of	IN
cord-350992-l6l24pco	303	18	reduced	reduced	JJ
cord-350992-l6l24pco	303	19	inflammation	inflammation	NN
cord-350992-l6l24pco	303	20	and	and	CC
cord-350992-l6l24pco	303	21	endothelial	endothelial	JJ
cord-350992-l6l24pco	303	22	dysfunction	dysfunction	NN
cord-350992-l6l24pco	304	1	Hydroxychloroquine	Hydroxychloroquine	NNP
cord-350992-l6l24pco	304	2	inhibits	inhibit	VBZ
cord-350992-l6l24pco	304	3	proinflammatory	proinflammatory	JJ
cord-350992-l6l24pco	304	4	signalling	signal	VBG
cord-350992-l6l24pco	304	5	pathways	pathway	NNS
cord-350992-l6l24pco	304	6	by	by	IN
cord-350992-l6l24pco	304	7	targeting	target	VBG
cord-350992-l6l24pco	304	8	endosomal	endosomal	NNP
cord-350992-l6l24pco	304	9	NADPH	NADPH	NNP
cord-350992-l6l24pco	304	10	oxidase	oxidase	NN
cord-350992-l6l24pco	304	11	Cholesterol	cholesterol	NN
cord-350992-l6l24pco	304	12	-	-	HYPH
cord-350992-l6l24pco	304	13	lowering	lower	VBG
cord-350992-l6l24pco	304	14	effect	effect	NN
cord-350992-l6l24pco	304	15	of	of	IN
cord-350992-l6l24pco	304	16	hydroxychloroquine	hydroxychloroquine	NN
cord-350992-l6l24pco	304	17	in	in	IN
cord-350992-l6l24pco	304	18	patients	patient	NNS
cord-350992-l6l24pco	304	19	with	with	IN
cord-350992-l6l24pco	304	20	rheumatic	rheumatic	JJ
cord-350992-l6l24pco	304	21	disease	disease	NN
cord-350992-l6l24pco	304	22	:	:	:
cord-350992-l6l24pco	304	23	reversal	reversal	NN
cord-350992-l6l24pco	304	24	of	of	IN
cord-350992-l6l24pco	304	25	deleterious	deleterious	JJ
cord-350992-l6l24pco	304	26	effects	effect	NNS
cord-350992-l6l24pco	304	27	of	of	IN
cord-350992-l6l24pco	304	28	steroids	steroid	NNS
cord-350992-l6l24pco	304	29	on	on	IN
cord-350992-l6l24pco	304	30	lipids	lipid	NNS
cord-350992-l6l24pco	304	31	Effect	Effect	NNP
cord-350992-l6l24pco	304	32	of	of	IN
cord-350992-l6l24pco	304	33	prednisone	prednisone	NNP
cord-350992-l6l24pco	304	34	and	and	CC
cord-350992-l6l24pco	304	35	hydroxychloroquine	hydroxychloroquine	NN
cord-350992-l6l24pco	304	36	on	on	IN
cord-350992-l6l24pco	304	37	coronary	coronary	JJ
cord-350992-l6l24pco	304	38	artery	artery	NN
cord-350992-l6l24pco	304	39	disease	disease	NN
cord-350992-l6l24pco	304	40	risk	risk	NN
cord-350992-l6l24pco	304	41	factors	factor	NNS
cord-350992-l6l24pco	304	42	in	in	IN
cord-350992-l6l24pco	304	43	systemic	systemic	JJ
cord-350992-l6l24pco	304	44	lupus	lupus	NN
cord-350992-l6l24pco	304	45	erythematosus	erythematosus	NN
cord-350992-l6l24pco	304	46	:	:	:
cord-350992-l6l24pco	304	47	a	a	DT
cord-350992-l6l24pco	304	48	longitudinal	longitudinal	JJ
cord-350992-l6l24pco	304	49	data	data	NN
cord-350992-l6l24pco	304	50	analysis	analysis	NN
cord-350992-l6l24pco	304	51	Longterm	longterm	JJ
cord-350992-l6l24pco	304	52	beneficial	beneficial	JJ
cord-350992-l6l24pco	304	53	effect	effect	NN
cord-350992-l6l24pco	304	54	of	of	IN
cord-350992-l6l24pco	304	55	chloroquine	chloroquine	NN
cord-350992-l6l24pco	304	56	diphosphate	diphosphate	NN
cord-350992-l6l24pco	304	57	on	on	IN
cord-350992-l6l24pco	304	58	lipoprotein	lipoprotein	NN
cord-350992-l6l24pco	304	59	profile	profile	NN
cord-350992-l6l24pco	304	60	in	in	IN
cord-350992-l6l24pco	304	61	lupus	lupus	NN
cord-350992-l6l24pco	304	62	patients	patient	NNS
cord-350992-l6l24pco	304	63	with	with	IN
cord-350992-l6l24pco	304	64	and	and	CC
cord-350992-l6l24pco	304	65	without	without	IN
cord-350992-l6l24pco	304	66	steroid	steroid	NN
cord-350992-l6l24pco	304	67	therapy	therapy	NN
cord-350992-l6l24pco	304	68	Iron	Iron	NNP
cord-350992-l6l24pco	304	69	metabolism	metabolism	NN
cord-350992-l6l24pco	304	70	and	and	CC
cord-350992-l6l24pco	304	71	iron	iron	NN
cord-350992-l6l24pco	304	72	disorders	disorder	NNS
cord-350992-l6l24pco	304	73	revisited	revisit	VBN
cord-350992-l6l24pco	304	74	in	in	IN
cord-350992-l6l24pco	304	75	the	the	DT
cord-350992-l6l24pco	304	76	hepcidin	hepcidin	NNP
cord-350992-l6l24pco	304	77	era	era	NN
cord-350992-l6l24pco	304	78	Protective	protective	JJ
cord-350992-l6l24pco	304	79	effect	effect	NN
cord-350992-l6l24pco	304	80	of	of	IN
cord-350992-l6l24pco	304	81	mitochondrial	mitochondrial	JJ
cord-350992-l6l24pco	304	82	ferritin	ferritin	NN
cord-350992-l6l24pco	304	83	on	on	IN
cord-350992-l6l24pco	304	84	cytosolic	cytosolic	JJ
cord-350992-l6l24pco	304	85	iron	iron	NN
cord-350992-l6l24pco	304	86	dysregulation	dysregulation	NN
cord-350992-l6l24pco	304	87	induced	induce	VBN
cord-350992-l6l24pco	304	88	by	by	IN
cord-350992-l6l24pco	304	89	doxorubicin	doxorubicin	NN
cord-350992-l6l24pco	304	90	in	in	IN
cord-350992-l6l24pco	304	91	HeLa	HeLa	NNP
cord-350992-l6l24pco	304	92	cells	cell	NNS
cord-350992-l6l24pco	305	1	Hepcidin	Hepcidin	NNP
cord-350992-l6l24pco	305	2	expression	expression	NN
cord-350992-l6l24pco	305	3	and	and	CC
cord-350992-l6l24pco	305	4	iron	iron	NN
cord-350992-l6l24pco	305	5	transport	transport	NN
cord-350992-l6l24pco	305	6	in	in	IN
cord-350992-l6l24pco	305	7	alveolar	alveolar	JJ
cord-350992-l6l24pco	305	8	macrophages	macrophage	NNS
cord-350992-l6l24pco	305	9	Silencing	silence	VBG
cord-350992-l6l24pco	305	10	airway	airway	JJ
cord-350992-l6l24pco	305	11	epithelial	epithelial	JJ
cord-350992-l6l24pco	305	12	cellderived	cellderived	NNP
cord-350992-l6l24pco	305	13	hepcidin	hepcidin	NNP
cord-350992-l6l24pco	305	14	exacerbates	exacerbate	VBZ
cord-350992-l6l24pco	305	15	sepsis	sepsis	NN
cord-350992-l6l24pco	305	16	induced	induce	VBD
cord-350992-l6l24pco	305	17	acute	acute	JJ
cord-350992-l6l24pco	305	18	lung	lung	NN
cord-350992-l6l24pco	305	19	injury	injury	NN
cord-350992-l6l24pco	305	20	.	.	.
cord-350992-l6l24pco	306	1	Crit	Crit	NNP
cord-350992-l6l24pco	306	2	Care	Care	NNP
cord-350992-l6l24pco	306	3	Airway	airway	NN
cord-350992-l6l24pco	306	4	Epithelial	epithelial	JJ
cord-350992-l6l24pco	306	5	Hepcidin	hepcidin	NN
cord-350992-l6l24pco	306	6	Coordinates	coordinate	VBZ
cord-350992-l6l24pco	306	7	Lung	lung	NN
cord-350992-l6l24pco	306	8	Macrophages	macrophage	NNS
cord-350992-l6l24pco	306	9	and	and	CC
cord-350992-l6l24pco	306	10	Immunity	Immunity	NNP
cord-350992-l6l24pco	306	11	Against	against	IN
cord-350992-l6l24pco	306	12	Bacterial	bacterial	JJ
cord-350992-l6l24pco	306	13	Pneumonia	Pneumonia	NNP
cord-350992-l6l24pco	306	14	.	.	.
cord-350992-l6l24pco	307	1	Shock	Shock	NNP
cord-350992-l6l24pco	307	2	Iron	Iron	NNP
cord-350992-l6l24pco	307	3	and	and	CC
cord-350992-l6l24pco	307	4	innate	innate	JJ
cord-350992-l6l24pco	307	5	antimicrobial	antimicrobial	JJ
cord-350992-l6l24pco	307	6	immunity-	immunity-	NN
cord-350992-l6l24pco	308	1	Depriving	deprive	VBG
cord-350992-l6l24pco	308	2	the	the	DT
cord-350992-l6l24pco	308	3	pathogen	pathogen	NN
cord-350992-l6l24pco	308	4	,	,	,
cord-350992-l6l24pco	308	5	defending	defend	VBG
cord-350992-l6l24pco	308	6	the	the	DT
cord-350992-l6l24pco	308	7	host	host	NN
cord-350992-l6l24pco	308	8	Iron	Iron	NNP
cord-350992-l6l24pco	308	9	and	and	CC
cord-350992-l6l24pco	308	10	Neurodegeneration	Neurodegeneration	NNP
cord-350992-l6l24pco	309	1	:	:	:
cord-350992-l6l24pco	309	2	Is	be	VBZ
cord-350992-l6l24pco	309	3	Ferritinophagy	Ferritinophagy	NNP
cord-350992-l6l24pco	309	4	the	the	DT
cord-350992-l6l24pco	309	5	Link	link	NN
cord-350992-l6l24pco	309	6	?	?	.
cord-350992-l6l24pco	310	1	How	how	WRB
cord-350992-l6l24pco	310	2	Eliminating	eliminate	VBG
cord-350992-l6l24pco	310	3	Malaria	Malaria	NNP
cord-350992-l6l24pco	311	1	May	May	MD
cord-350992-l6l24pco	311	2	Also	also	RB
cord-350992-l6l24pco	311	3	Prevent	Prevent	NNP
cord-350992-l6l24pco	311	4	Iron	Iron	NNP
cord-350992-l6l24pco	311	5	Deficiency	deficiency	NN
cord-350992-l6l24pco	311	6	in	in	IN
cord-350992-l6l24pco	311	7	African	african	JJ
cord-350992-l6l24pco	311	8	Children	Children	NNP
cord-350992-l6l24pco	311	9	Relationship	Relationship	NNP
cord-350992-l6l24pco	311	10	between	between	IN
cord-350992-l6l24pco	311	11	chloroquine	chloroquine	NN
cord-350992-l6l24pco	311	12	toxicity	toxicity	NN
cord-350992-l6l24pco	311	13	and	and	CC
cord-350992-l6l24pco	311	14	iron	iron	NN
cord-350992-l6l24pco	311	15	acquisition	acquisition	NN
cord-350992-l6l24pco	311	16	in	in	IN
cord-350992-l6l24pco	311	17	Saccharomyces	Saccharomyces	NNP
cord-350992-l6l24pco	311	18	cerevisiae	cerevisiae	NN
cord-350992-l6l24pco	311	19	Transferrin	Transferrin	NNP
cord-350992-l6l24pco	311	20	uptake	uptake	NN
cord-350992-l6l24pco	311	21	by	by	IN
cord-350992-l6l24pco	311	22	cultured	cultured	JJ
cord-350992-l6l24pco	311	23	rat	rat	NN
cord-350992-l6l24pco	311	24	embryo	embryo	NN
cord-350992-l6l24pco	311	25	fibroblasts	fibroblast	NNS
cord-350992-l6l24pco	311	26	.	.	.
cord-350992-l6l24pco	312	1	The	the	DT
cord-350992-l6l24pco	312	2	influence	influence	NN
cord-350992-l6l24pco	312	3	of	of	IN
cord-350992-l6l24pco	312	4	lysosomotropic	lysosomotropic	JJ
cord-350992-l6l24pco	312	5	agents	agent	NNS
cord-350992-l6l24pco	312	6	,	,	,
cord-350992-l6l24pco	312	7	iron	iron	NN
cord-350992-l6l24pco	312	8	chelators	chelator	NNS
cord-350992-l6l24pco	312	9	and	and	CC
cord-350992-l6l24pco	312	10	colchicine	colchicine	NN
cord-350992-l6l24pco	312	11	on	on	IN
cord-350992-l6l24pco	312	12	the	the	DT
cord-350992-l6l24pco	312	13	uptake	uptake	NN
cord-350992-l6l24pco	312	14	of	of	IN
cord-350992-l6l24pco	312	15	iron	iron	NN
cord-350992-l6l24pco	312	16	and	and	CC
cord-350992-l6l24pco	312	17	transferrin	transferrin	VB
cord-350992-l6l24pco	312	18	The	the	DT
cord-350992-l6l24pco	312	19	transferrin	transferrin	NN
cord-350992-l6l24pco	312	20	receptor	receptor	NN
cord-350992-l6l24pco	312	21	:	:	:
cord-350992-l6l24pco	312	22	the	the	DT
cord-350992-l6l24pco	312	23	cellular	cellular	JJ
cord-350992-l6l24pco	312	24	iron	iron	NN
cord-350992-l6l24pco	312	25	gate	gate	NN
cord-350992-l6l24pco	312	26	Mutations	Mutations	NNPS
cord-350992-l6l24pco	312	27	in	in	IN
cord-350992-l6l24pco	312	28	the	the	DT
cord-350992-l6l24pco	312	29	murine	murine	JJ
cord-350992-l6l24pco	312	30	fitness	fitness	NN
cord-350992-l6l24pco	312	31	1	1	CD
cord-350992-l6l24pco	312	32	gene	gene	NN
cord-350992-l6l24pco	312	33	result	result	NN
cord-350992-l6l24pco	312	34	in	in	IN
cord-350992-l6l24pco	312	35	defective	defective	JJ
cord-350992-l6l24pco	312	36	hematopoiesis	hematopoiesis	NN
cord-350992-l6l24pco	312	37	Alterations	alteration	NNS
cord-350992-l6l24pco	312	38	in	in	IN
cord-350992-l6l24pco	312	39	serum	serum	NN
cord-350992-l6l24pco	312	40	and	and	CC
cord-350992-l6l24pco	312	41	tissue	tissue	NN
cord-350992-l6l24pco	312	42	iron	iron	NN
cord-350992-l6l24pco	312	43	profiles	profile	NNS
cord-350992-l6l24pco	312	44	associated	associate	VBN
cord-350992-l6l24pco	312	45	with	with	IN
cord-350992-l6l24pco	312	46	mutations	mutation	NNS
cord-350992-l6l24pco	312	47	in	in	IN
cord-350992-l6l24pco	312	48	thefitness1	thefitness1	NN
cord-350992-l6l24pco	312	49	4226sb	4226sb	CD
cord-350992-l6l24pco	312	50	locus	locus	NN
cord-350992-l6l24pco	312	51	of	of	IN
cord-350992-l6l24pco	312	52	mice	mouse	NNS
cord-350992-l6l24pco	313	1	The	the	DT
cord-350992-l6l24pco	313	2	PICALM	PICALM	NNP
cord-350992-l6l24pco	313	3	protein	protein	NN
cord-350992-l6l24pco	313	4	plays	play	VBZ
cord-350992-l6l24pco	313	5	a	a	DT
cord-350992-l6l24pco	313	6	key	key	JJ
cord-350992-l6l24pco	313	7	role	role	NN
cord-350992-l6l24pco	313	8	in	in	IN
cord-350992-l6l24pco	313	9	iron	iron	NN
cord-350992-l6l24pco	313	10	homeostasis	homeostasis	NN
cord-350992-l6l24pco	313	11	and	and	CC
cord-350992-l6l24pco	313	12	cell	cell	NN
cord-350992-l6l24pco	313	13	proliferation	proliferation	NN
cord-350992-l6l24pco	313	14	H(+)-coupled	h(+)-coupled	CD
cord-350992-l6l24pco	313	15	divalent	divalent	JJ
cord-350992-l6l24pco	313	16	metal	metal	NN
cord-350992-l6l24pco	313	17	-	-	HYPH
cord-350992-l6l24pco	313	18	ion	ion	NN
cord-350992-l6l24pco	313	19	transporter-1	transporter-1	IN
cord-350992-l6l24pco	313	20	:	:	:
cord-350992-l6l24pco	313	21	functional	functional	JJ
cord-350992-l6l24pco	313	22	properties	property	NNS
cord-350992-l6l24pco	313	23	,	,	,
cord-350992-l6l24pco	313	24	physiological	physiological	JJ
cord-350992-l6l24pco	313	25	roles	role	NNS
cord-350992-l6l24pco	313	26	and	and	CC
cord-350992-l6l24pco	313	27	therapeutics	therapeutic	NNS
cord-350992-l6l24pco	313	28	TRPML1	TRPML1	NNP
cord-350992-l6l24pco	313	29	:	:	:
cord-350992-l6l24pco	314	1	The	the	DT
cord-350992-l6l24pco	314	2	Ca	Ca	NNP
cord-350992-l6l24pco	314	3	(	(	-LRB-
cord-350992-l6l24pco	314	4	2	2	CD
cord-350992-l6l24pco	314	5	+	+	SYM
cord-350992-l6l24pco	314	6	)	)	-RRB-
cord-350992-l6l24pco	314	7	retaker	retaker	NNP
cord-350992-l6l24pco	314	8	of	of	IN
cord-350992-l6l24pco	314	9	the	the	DT
cord-350992-l6l24pco	314	10	lysosome	lysosome	NN
cord-350992-l6l24pco	315	1	Quantitative	quantitative	JJ
cord-350992-l6l24pco	315	2	proteomics	proteomic	NNS
cord-350992-l6l24pco	315	3	identifies	identify	VBZ
cord-350992-l6l24pco	315	4	NCOA4	NCOA4	NNP
cord-350992-l6l24pco	315	5	as	as	IN
cord-350992-l6l24pco	315	6	the	the	DT
cord-350992-l6l24pco	315	7	cargo	cargo	NN
cord-350992-l6l24pco	315	8	receptor	receptor	NN
cord-350992-l6l24pco	315	9	mediating	mediate	VBG
cord-350992-l6l24pco	315	10	ferritinophagy	ferritinophagy	NNP
cord-350992-l6l24pco	315	11	Artesunate	Artesunate	NNP
cord-350992-l6l24pco	315	12	alleviates	alleviate	VBZ
cord-350992-l6l24pco	315	13	liver	liver	NN
cord-350992-l6l24pco	315	14	fibrosis	fibrosis	NN
cord-350992-l6l24pco	315	15	by	by	IN
cord-350992-l6l24pco	315	16	regulating	regulate	VBG
cord-350992-l6l24pco	315	17	ferroptosis	ferroptosis	NNP
cord-350992-l6l24pco	315	18	signaling	signal	VBG
cord-350992-l6l24pco	315	19	pathway	pathway	NN
cord-350992-l6l24pco	315	20	Tissue	tissue	NN
cord-350992-l6l24pco	315	21	distribution	distribution	NN
cord-350992-l6l24pco	315	22	of	of	IN
cord-350992-l6l24pco	315	23	ACE2	ACE2	NNP
cord-350992-l6l24pco	315	24	protein	protein	NN
cord-350992-l6l24pco	315	25	,	,	,
cord-350992-l6l24pco	315	26	the	the	DT
cord-350992-l6l24pco	315	27	functional	functional	JJ
cord-350992-l6l24pco	315	28	receptor	receptor	NN
cord-350992-l6l24pco	315	29	for	for	IN
cord-350992-l6l24pco	315	30	SARS	SARS	NNP
cord-350992-l6l24pco	315	31	coronavirus	coronavirus	NN
cord-350992-l6l24pco	315	32	.	.	.
cord-350992-l6l24pco	316	1	A	a	DT
cord-350992-l6l24pco	316	2	first	first	JJ
cord-350992-l6l24pco	316	3	step	step	NN
cord-350992-l6l24pco	316	4	in	in	IN
cord-350992-l6l24pco	316	5	understanding	understand	VBG
cord-350992-l6l24pco	316	6	SARS	SARS	NNP
cord-350992-l6l24pco	316	7	pathogenesis	pathogenesis	NN
cord-350992-l6l24pco	317	1	The	the	DT
cord-350992-l6l24pco	317	2	Thrombopoietin	Thrombopoietin	NNP
cord-350992-l6l24pco	317	3	Receptor	Receptor	NNP
cord-350992-l6l24pco	317	4	Agonist	Agonist	NNP
cord-350992-l6l24pco	317	5	Eltrombopag	Eltrombopag	NNP
cord-350992-l6l24pco	317	6	Inhibits	inhibit	VBZ
cord-350992-l6l24pco	317	7	Human	human	JJ
cord-350992-l6l24pco	317	8	Cytomegalovirus	Cytomegalovirus	NNP
cord-350992-l6l24pco	317	9	Replication	replication	NN
cord-350992-l6l24pco	317	10	Via	Via	NNP
cord-350992-l6l24pco	317	11	Iron	Iron	NNP
cord-350992-l6l24pco	317	12	Chelation	Chelation	NNP
cord-350992-l6l24pco	317	13	.	.	.
cord-350992-l6l24pco	318	1	Cells	cell	NNS
cord-350992-l6l24pco	318	2	Effect	effect	NN
cord-350992-l6l24pco	318	3	of	of	IN
cord-350992-l6l24pco	318	4	mouse	mouse	NN
cord-350992-l6l24pco	318	5	hepatitis	hepatitis	NN
cord-350992-l6l24pco	318	6	virus	virus	NN
cord-350992-l6l24pco	318	7	infection	infection	NN
cord-350992-l6l24pco	318	8	on	on	IN
cord-350992-l6l24pco	318	9	iron	iron	NN
cord-350992-l6l24pco	318	10	retention	retention	NN
cord-350992-l6l24pco	318	11	in	in	IN
cord-350992-l6l24pco	318	12	the	the	DT
cord-350992-l6l24pco	318	13	mouse	mouse	NN
cord-350992-l6l24pco	318	14	liver	liver	NN
cord-350992-l6l24pco	319	1	HFE	HFE	NNP
cord-350992-l6l24pco	319	2	Related	Related	NNP
cord-350992-l6l24pco	319	3	Hemochromatosis	Hemochromatosis	NNP
cord-350992-l6l24pco	319	4	:	:	:
cord-350992-l6l24pco	320	1	Uncovering	uncover	VBG
cord-350992-l6l24pco	320	2	the	the	DT
cord-350992-l6l24pco	320	3	Inextricable	inextricable	JJ
cord-350992-l6l24pco	320	4	Link	link	NN
cord-350992-l6l24pco	320	5	between	between	IN
cord-350992-l6l24pco	320	6	Iron	Iron	NNP
cord-350992-l6l24pco	320	7	Homeostasis	Homeostasis	NNP
cord-350992-l6l24pco	320	8	and	and	CC
cord-350992-l6l24pco	320	9	the	the	DT
cord-350992-l6l24pco	320	10	Immunological	Immunological	NNP
cord-350992-l6l24pco	320	11	System	System	NNP
cord-350992-l6l24pco	320	12	.	.	.
cord-350992-l6l24pco	321	1	Pharmaceuticals	pharmaceutical	NNS
cord-350992-l6l24pco	321	2	(	(	-LRB-
cord-350992-l6l24pco	321	3	Basel	Basel	NNP
cord-350992-l6l24pco	321	4	)	)	-RRB-
cord-350992-l6l24pco	321	5	COVID-19	covid-19	CD
cord-350992-l6l24pco	321	6	:	:	:
cord-350992-l6l24pco	321	7	immunopathology	immunopathology	NN
cord-350992-l6l24pco	321	8	and	and	CC
cord-350992-l6l24pco	321	9	its	-PRON-	PRP$
cord-350992-l6l24pco	321	10	implications	implication	NNS
cord-350992-l6l24pco	321	11	for	for	IN
cord-350992-l6l24pco	321	12	therapy	therapy	NN
cord-350992-l6l24pco	321	13	Immunopathogenesis	Immunopathogenesis	NNP
cord-350992-l6l24pco	321	14	of	of	IN
cord-350992-l6l24pco	321	15	coronavirus	coronavirus	NN
cord-350992-l6l24pco	321	16	infections	infection	NNS
cord-350992-l6l24pco	321	17	:	:	:
cord-350992-l6l24pco	321	18	implications	implication	NNS
cord-350992-l6l24pco	321	19	for	for	IN
cord-350992-l6l24pco	321	20	SARS	SARS	NNP
cord-350992-l6l24pco	321	21	SARS	SARS	NNP
cord-350992-l6l24pco	321	22	coronavirus	coronavirus	NN
cord-350992-l6l24pco	321	23	and	and	CC
cord-350992-l6l24pco	321	24	innate	innate	JJ
cord-350992-l6l24pco	321	25	immunity	immunity	NN
cord-350992-l6l24pco	321	26	Pathogenic	pathogenic	JJ
cord-350992-l6l24pco	321	27	human	human	JJ
cord-350992-l6l24pco	321	28	coronavirus	coronavirus	NN
cord-350992-l6l24pco	321	29	infections	infection	NNS
cord-350992-l6l24pco	321	30	:	:	:
cord-350992-l6l24pco	321	31	causes	cause	NNS
cord-350992-l6l24pco	321	32	and	and	CC
cord-350992-l6l24pco	321	33	consequences	consequence	NNS
cord-350992-l6l24pco	321	34	of	of	IN
cord-350992-l6l24pco	321	35	cytokine	cytokine	NN
cord-350992-l6l24pco	321	36	storm	storm	NN
cord-350992-l6l24pco	321	37	and	and	CC
cord-350992-l6l24pco	321	38	immunopathology	immunopathology	NN
cord-350992-l6l24pco	321	39	Iron	iron	NN
cord-350992-l6l24pco	321	40	levels	level	NNS
cord-350992-l6l24pco	321	41	in	in	IN
cord-350992-l6l24pco	321	42	polarized	polarized	JJ
cord-350992-l6l24pco	321	43	macrophages	macrophage	NNS
cord-350992-l6l24pco	321	44	:	:	:
cord-350992-l6l24pco	321	45	regulation	regulation	NN
cord-350992-l6l24pco	321	46	of	of	IN
cord-350992-l6l24pco	321	47	immunity	immunity	NN
cord-350992-l6l24pco	321	48	and	and	CC
cord-350992-l6l24pco	321	49	autoimmunity	autoimmunity	IN
cord-350992-l6l24pco	321	50	Effect	effect	NN
cord-350992-l6l24pco	321	51	of	of	IN
cord-350992-l6l24pco	321	52	chronic	chronic	JJ
cord-350992-l6l24pco	321	53	chloroquine	chloroquine	NNP
cord-350992-l6l24pco	321	54	administration	administration	NN
cord-350992-l6l24pco	321	55	on	on	IN
cord-350992-l6l24pco	321	56	iron	iron	NN
cord-350992-l6l24pco	321	57	loading	loading	NN
cord-350992-l6l24pco	321	58	in	in	IN
cord-350992-l6l24pco	321	59	the	the	DT
cord-350992-l6l24pco	321	60	liver	liver	NN
cord-350992-l6l24pco	321	61	and	and	CC
cord-350992-l6l24pco	321	62	reticuloendothelial	reticuloendothelial	JJ
cord-350992-l6l24pco	321	63	system	system	NN
cord-350992-l6l24pco	321	64	and	and	CC
cord-350992-l6l24pco	321	65	on	on	IN
cord-350992-l6l24pco	321	66	oxidative	oxidative	JJ
cord-350992-l6l24pco	321	67	responses	response	NNS
cord-350992-l6l24pco	321	68	by	by	IN
cord-350992-l6l24pco	321	69	the	the	DT
cord-350992-l6l24pco	321	70	alveolar	alveolar	NN
cord-350992-l6l24pco	321	71	macrophages	macrophage	NNS
cord-350992-l6l24pco	321	72	Changes	change	NNS
cord-350992-l6l24pco	321	73	in	in	IN
cord-350992-l6l24pco	321	74	function	function	NN
cord-350992-l6l24pco	321	75	of	of	IN
cord-350992-l6l24pco	321	76	iron	iron	NN
cord-350992-l6l24pco	321	77	-	-	HYPH
cord-350992-l6l24pco	321	78	loaded	load	VBN
cord-350992-l6l24pco	321	79	alveolar	alveolar	NN
cord-350992-l6l24pco	321	80	macrophages	macrophage	NNS
cord-350992-l6l24pco	321	81	after	after	IN
cord-350992-l6l24pco	321	82	in	in	IN
cord-350992-l6l24pco	321	83	vivo	vivo	NNP
cord-350992-l6l24pco	321	84	administration	administration	NNP
cord-350992-l6l24pco	321	85	of	of	IN
cord-350992-l6l24pco	321	86	desferrioxamine	desferrioxamine	NNP
cord-350992-l6l24pco	321	87	and/or	and/or	CC
cord-350992-l6l24pco	321	88	chloroquine	chloroquine	NNP
cord-350992-l6l24pco	321	89	Hemochromatosis	Hemochromatosis	NNP
cord-350992-l6l24pco	321	90	(	(	-LRB-
cord-350992-l6l24pco	321	91	HFE	HFE	NNP
cord-350992-l6l24pco	321	92	)	)	-RRB-
cord-350992-l6l24pco	321	93	gene	gene	NN
cord-350992-l6l24pco	321	94	mutations	mutation	NNS
cord-350992-l6l24pco	321	95	and	and	CC
cord-350992-l6l24pco	321	96	response	response	NN
cord-350992-l6l24pco	321	97	to	to	IN
cord-350992-l6l24pco	321	98	chloroquine	chloroquine	NN
cord-350992-l6l24pco	321	99	in	in	IN
cord-350992-l6l24pco	321	100	porphyria	porphyria	NN
cord-350992-l6l24pco	321	101	cutanea	cutanea	NNP
cord-350992-l6l24pco	321	102	tarda	tarda	NNP
cord-350992-l6l24pco	321	103	Effects	effect	NNS
cord-350992-l6l24pco	321	104	of	of	IN
cord-350992-l6l24pco	321	105	pristane	pristane	NNP
cord-350992-l6l24pco	321	106	alone	alone	JJ
cord-350992-l6l24pco	321	107	or	or	CC
cord-350992-l6l24pco	321	108	combined	combine	VBN
cord-350992-l6l24pco	321	109	with	with	IN
cord-350992-l6l24pco	321	110	chloroquine	chloroquine	NN
cord-350992-l6l24pco	321	111	on	on	IN
cord-350992-l6l24pco	321	112	macrophage	macrophage	NN
cord-350992-l6l24pco	321	113	activation	activation	NN
cord-350992-l6l24pco	321	114	,	,	,
cord-350992-l6l24pco	321	115	oxidative	oxidative	JJ
cord-350992-l6l24pco	321	116	stress	stress	NN
cord-350992-l6l24pco	321	117	,	,	,
cord-350992-l6l24pco	321	118	and	and	CC
cord-350992-l6l24pco	321	119	TH1	TH1	NNP
cord-350992-l6l24pco	321	120	/	/	SYM
cord-350992-l6l24pco	321	121	TH2	TH2	NNP
cord-350992-l6l24pco	321	122	skewness	skewness	NN
cord-350992-l6l24pco	321	123	Iron	Iron	NNP
cord-350992-l6l24pco	321	124	Metabolism	Metabolism	NNP
cord-350992-l6l24pco	321	125	and	and	CC
cord-350992-l6l24pco	321	126	the	the	DT
cord-350992-l6l24pco	321	127	Inflammatory	Inflammatory	NNP
cord-350992-l6l24pco	321	128	Response	Response	NNP
cord-350992-l6l24pco	321	129	.	.	.
cord-350992-l6l24pco	322	1	IUBMB	IUBMB	NNP
cord-350992-l6l24pco	322	2	Life	Life	NNP
cord-350992-l6l24pco	323	1	The	the	DT
cord-350992-l6l24pco	323	2	role	role	NN
cord-350992-l6l24pco	323	3	of	of	IN
cord-350992-l6l24pco	323	4	iron	iron	NN
cord-350992-l6l24pco	323	5	and	and	CC
cord-350992-l6l24pco	323	6	iron	iron	NN
cord-350992-l6l24pco	323	7	binding	binding	NN
cord-350992-l6l24pco	323	8	proteins	protein	NNS
cord-350992-l6l24pco	323	9	in	in	IN
cord-350992-l6l24pco	323	10	lymphocyte	lymphocyte	NN
cord-350992-l6l24pco	323	11	physiology	physiology	NN
cord-350992-l6l24pco	323	12	and	and	CC
cord-350992-l6l24pco	323	13	pathology	pathology	NN
cord-350992-l6l24pco	323	14	Anti	Anti	NNP
cord-350992-l6l24pco	323	15	-	-	NNP
cord-350992-l6l24pco	323	16	TNF	TNF	NNP
cord-350992-l6l24pco	323	17	-	-	HYPH
cord-350992-l6l24pco	323	18	α	α	NNP
cord-350992-l6l24pco	323	19	Monoclonal	Monoclonal	NNP
cord-350992-l6l24pco	323	20	Antibody	Antibody	NNP
cord-350992-l6l24pco	323	21	Therapy	Therapy	NNP
cord-350992-l6l24pco	323	22	Improves	improve	VBZ
cord-350992-l6l24pco	323	23	Anemia	anemia	NN
cord-350992-l6l24pco	323	24	through	through	IN
cord-350992-l6l24pco	323	25	Downregulating	Downregulating	NNP
cord-350992-l6l24pco	323	26	Hepatocyte	Hepatocyte	NNP
cord-350992-l6l24pco	323	27	Hepcidin	Hepcidin	NNP
cord-350992-l6l24pco	323	28	Expression	expression	NN
cord-350992-l6l24pco	323	29	in	in	IN
cord-350992-l6l24pco	323	30	Inflammatory	inflammatory	JJ
cord-350992-l6l24pco	323	31	Bowel	Bowel	NNP
cord-350992-l6l24pco	323	32	Disease	Disease	NNP
cord-350992-l6l24pco	324	1	Does	do	VBZ
cord-350992-l6l24pco	324	2	recombinant	recombinant	JJ
cord-350992-l6l24pco	324	3	human	human	JJ
cord-350992-l6l24pco	324	4	Erythropoietin	Erythropoietin	NNP
cord-350992-l6l24pco	324	5	administration	administration	NN
cord-350992-l6l24pco	324	6	in	in	IN
cord-350992-l6l24pco	324	7	critically	critically	RB
cord-350992-l6l24pco	324	8	ill	ill	JJ
cord-350992-l6l24pco	325	1	COVID-19	covid-19	JJ
cord-350992-l6l24pco	325	2	patients	patient	NNS
cord-350992-l6l24pco	325	3	have	have	VBP
cord-350992-l6l24pco	325	4	miraculous	miraculous	JJ
cord-350992-l6l24pco	325	5	therapeutic	therapeutic	JJ
cord-350992-l6l24pco	325	6	effects	effect	NNS
cord-350992-l6l24pco	325	7	COVID-19	covid-19	VBP
cord-350992-l6l24pco	325	8	:	:	:
cord-350992-l6l24pco	325	9	Attacks	attack	NNS
cord-350992-l6l24pco	325	10	the	the	DT
cord-350992-l6l24pco	325	11	1-Beta	1-beta	CD
cord-350992-l6l24pco	325	12	Chain	Chain	NNP
cord-350992-l6l24pco	325	13	of	of	IN
cord-350992-l6l24pco	325	14	Hemoglobin	Hemoglobin	NNP
cord-350992-l6l24pco	325	15	and	and	CC
cord-350992-l6l24pco	325	16	Captures	capture	VBZ
cord-350992-l6l24pco	325	17	the	the	DT
cord-350992-l6l24pco	325	18	Porphyrin	Porphyrin	NNP
cord-350992-l6l24pco	325	19	to	to	TO
cord-350992-l6l24pco	325	20	Inhibit	inhibit	VB
cord-350992-l6l24pco	325	21	Human	human	JJ
cord-350992-l6l24pco	325	22	Heme	Heme	NNP
cord-350992-l6l24pco	325	23	Metabolism	Metabolism	NNP
cord-350992-l6l24pco	325	24	Iron	Iron	NNP
cord-350992-l6l24pco	325	25	deficiency	deficiency	NN
cord-350992-l6l24pco	325	26	and	and	CC
cord-350992-l6l24pco	325	27	thrombosis	thrombosis	NN
cord-350992-l6l24pco	325	28	:	:	:
cord-350992-l6l24pco	326	1	literature	literature	NN
cord-350992-l6l24pco	326	2	review	review	NN
cord-350992-l6l24pco	326	3	Iron	Iron	NNP
cord-350992-l6l24pco	326	4	deficiency	deficiency	NN
cord-350992-l6l24pco	326	5	anemia	anemia	NN
cord-350992-l6l24pco	326	6	as	as	IN
cord-350992-l6l24pco	326	7	a	a	DT
cord-350992-l6l24pco	326	8	risk	risk	NN
cord-350992-l6l24pco	326	9	factor	factor	NN
cord-350992-l6l24pco	326	10	for	for	IN
cord-350992-l6l24pco	326	11	cerebrovascular	cerebrovascular	JJ
cord-350992-l6l24pco	326	12	events	event	NNS
cord-350992-l6l24pco	326	13	in	in	IN
cord-350992-l6l24pco	326	14	early	early	JJ
cord-350992-l6l24pco	326	15	childhood	childhood	NN
cord-350992-l6l24pco	326	16	:	:	:
cord-350992-l6l24pco	327	1	a	a	DT
cord-350992-l6l24pco	327	2	case	case	NN
cord-350992-l6l24pco	327	3	-	-	HYPH
cord-350992-l6l24pco	327	4	control	control	NN
cord-350992-l6l24pco	327	5	study	study	NNP
cord-350992-l6l24pco	327	6	Association	Association	NNP
cord-350992-l6l24pco	327	7	between	between	IN
cord-350992-l6l24pco	327	8	ischemic	ischemic	JJ
cord-350992-l6l24pco	327	9	stroke	stroke	NN
cord-350992-l6l24pco	327	10	and	and	CC
cord-350992-l6l24pco	327	11	irondeficiency	irondeficiency	NNP
cord-350992-l6l24pco	327	12	anemia	anemia	NN
cord-350992-l6l24pco	327	13	:	:	:
cord-350992-l6l24pco	328	1	a	a	DT
cord-350992-l6l24pco	328	2	population	population	NN
cord-350992-l6l24pco	328	3	-	-	HYPH
cord-350992-l6l24pco	328	4	based	base	VBN
cord-350992-l6l24pco	328	5	study	study	NN
cord-350992-l6l24pco	328	6	Association	Association	NNP
cord-350992-l6l24pco	328	7	between	between	IN
cord-350992-l6l24pco	328	8	venous	venous	JJ
cord-350992-l6l24pco	328	9	thromboembolism	thromboembolism	NN
cord-350992-l6l24pco	328	10	and	and	CC
cord-350992-l6l24pco	328	11	iron	iron	NN
cord-350992-l6l24pco	328	12	-	-	HYPH
cord-350992-l6l24pco	328	13	deficiency	deficiency	NN
cord-350992-l6l24pco	328	14	anemia	anemia	NN
cord-350992-l6l24pco	328	15	:	:	:
cord-350992-l6l24pco	328	16	a	a	DT
cord-350992-l6l24pco	328	17	population	population	NN
cord-350992-l6l24pco	328	18	-	-	HYPH
cord-350992-l6l24pco	328	19	based	base	VBN
cord-350992-l6l24pco	328	20	study	study	NN
cord-350992-l6l24pco	328	21	Characterization	characterization	NN
cord-350992-l6l24pco	328	22	of	of	IN
cord-350992-l6l24pco	328	23	the	the	DT
cord-350992-l6l24pco	328	24	Rate	rate	NN
cord-350992-l6l24pco	328	25	,	,	,
cord-350992-l6l24pco	328	26	Predictors	Predictors	NNP
cord-350992-l6l24pco	328	27	,	,	,
cord-350992-l6l24pco	328	28	and	and	CC
cord-350992-l6l24pco	328	29	Thrombotic	Thrombotic	NNP
cord-350992-l6l24pco	328	30	Complications	Complications	NNPS
cord-350992-l6l24pco	328	31	of	of	IN
cord-350992-l6l24pco	328	32	Thrombocytosis	Thrombocytosis	NNP
cord-350992-l6l24pco	328	33	in	in	IN
cord-350992-l6l24pco	328	34	Iron	Iron	NNP
cord-350992-l6l24pco	328	35	Deficiency	Deficiency	NNP
cord-350992-l6l24pco	328	36	Anemia	anemia	NN
cord-350992-l6l24pco	328	37	Difference	Difference	NNP
cord-350992-l6l24pco	328	38	of	of	IN
cord-350992-l6l24pco	328	39	coagulation	coagulation	NN
cord-350992-l6l24pco	328	40	features	feature	NNS
cord-350992-l6l24pco	328	41	between	between	IN
cord-350992-l6l24pco	328	42	severe	severe	JJ
cord-350992-l6l24pco	328	43	pneumonia	pneumonia	NN
cord-350992-l6l24pco	328	44	induced	induce	VBN
cord-350992-l6l24pco	328	45	by	by	IN
cord-350992-l6l24pco	328	46	SARS	SARS	NNP
cord-350992-l6l24pco	328	47	-	-	HYPH
cord-350992-l6l24pco	328	48	CoV2	CoV2	NNP
cord-350992-l6l24pco	328	49	and	and	CC
cord-350992-l6l24pco	328	50	non	non	JJ
cord-350992-l6l24pco	328	51	-	-	JJ
cord-350992-l6l24pco	328	52	SARS	SARS	NNP
cord-350992-l6l24pco	328	53	-	-	HYPH
cord-350992-l6l24pco	328	54	CoV2	CoV2	NNP
cord-350992-l6l24pco	328	55	Anticoagulant	anticoagulant	JJ
cord-350992-l6l24pco	328	56	treatment	treatment	NN
cord-350992-l6l24pco	328	57	is	be	VBZ
cord-350992-l6l24pco	328	58	associated	associate	VBN
cord-350992-l6l24pco	328	59	with	with	IN
cord-350992-l6l24pco	328	60	decreased	decrease	VBN
cord-350992-l6l24pco	328	61	mortality	mortality	NN
cord-350992-l6l24pco	328	62	in	in	IN
cord-350992-l6l24pco	328	63	severe	severe	JJ
cord-350992-l6l24pco	328	64	coronavirus	coronavirus	NN
cord-350992-l6l24pco	328	65	disease	disease	NN
cord-350992-l6l24pco	328	66	2019	2019	CD
cord-350992-l6l24pco	328	67	patients	patient	NNS
cord-350992-l6l24pco	328	68	with	with	IN
cord-350992-l6l24pco	328	69	coagulopathy	coagulopathy	NN
cord-350992-l6l24pco	328	70	Iron	Iron	NNP
cord-350992-l6l24pco	328	71	deficiency	deficiency	NN
cord-350992-l6l24pco	328	72	induced	induce	VBD
cord-350992-l6l24pco	328	73	thrombocytosis	thrombocytosis	NNP
cord-350992-l6l24pco	328	74	increases	increase	VBZ
cord-350992-l6l24pco	328	75	thrombotic	thrombotic	JJ
cord-350992-l6l24pco	328	76	tendency	tendency	NN
cord-350992-l6l24pco	328	77	in	in	IN
cord-350992-l6l24pco	328	78	rats	rat	NNS
cord-350992-l6l24pco	329	1	Heparin	Heparin	NNP
cord-350992-l6l24pco	329	2	inhibits	inhibit	VBZ
cord-350992-l6l24pco	329	3	intracellular	intracellular	JJ
cord-350992-l6l24pco	329	4	Mycobacterium	Mycobacterium	NNP
cord-350992-l6l24pco	329	5	tuberculosis	tuberculosis	NN
cord-350992-l6l24pco	329	6	bacterial	bacterial	JJ
cord-350992-l6l24pco	329	7	replication	replication	NN
cord-350992-l6l24pco	329	8	by	by	IN
cord-350992-l6l24pco	329	9	reducing	reduce	VBG
cord-350992-l6l24pco	329	10	iron	iron	NN
cord-350992-l6l24pco	329	11	levels	level	NNS
cord-350992-l6l24pco	329	12	in	in	IN
cord-350992-l6l24pco	329	13	human	human	JJ
cord-350992-l6l24pco	329	14	macrophages	macrophage	NNS
cord-350992-l6l24pco	329	15	Treating	treat	VBG
cord-350992-l6l24pco	329	16	COVID-19	covid-19	CD
cord-350992-l6l24pco	329	17	with	with	IN
cord-350992-l6l24pco	329	18	Chloroquine	Chloroquine	NNP
cord-350992-l6l24pco	329	19	Hydroxychloroquine	Hydroxychloroquine	NNP
cord-350992-l6l24pco	329	20	and	and	CC
cord-350992-l6l24pco	329	21	azithromycin	azithromycin	NNP
cord-350992-l6l24pco	329	22	as	as	IN
cord-350992-l6l24pco	329	23	a	a	DT
cord-350992-l6l24pco	329	24	treatment	treatment	NN
cord-350992-l6l24pco	329	25	of	of	IN
cord-350992-l6l24pco	329	26	COVID-19	covid-19	NN
cord-350992-l6l24pco	329	27	:	:	:
cord-350992-l6l24pco	329	28	results	result	NNS
cord-350992-l6l24pco	329	29	of	of	IN
cord-350992-l6l24pco	329	30	an	an	DT
cord-350992-l6l24pco	329	31	open	open	JJ
cord-350992-l6l24pco	329	32	-	-	HYPH
cord-350992-l6l24pco	329	33	label	label	NN
cord-350992-l6l24pco	329	34	nonrandomized	nonrandomize	VBN
cord-350992-l6l24pco	329	35	clinical	clinical	JJ
cord-350992-l6l24pco	329	36	trial	trial	NN
cord-350992-l6l24pco	329	37	Clinical	clinical	JJ
cord-350992-l6l24pco	329	38	and	and	CC
cord-350992-l6l24pco	329	39	microbiological	microbiological	JJ
cord-350992-l6l24pco	329	40	effect	effect	NN
cord-350992-l6l24pco	329	41	of	of	IN
cord-350992-l6l24pco	329	42	a	a	DT
cord-350992-l6l24pco	329	43	combination	combination	NN
cord-350992-l6l24pco	329	44	of	of	IN
cord-350992-l6l24pco	329	45	hydroxychloroquine	hydroxychloroquine	NN
cord-350992-l6l24pco	329	46	and	and	CC
cord-350992-l6l24pco	329	47	azithromycin	azithromycin	NNP
cord-350992-l6l24pco	329	48	in	in	IN
cord-350992-l6l24pco	329	49	80	80	CD
cord-350992-l6l24pco	329	50	COVID-19	covid-19	JJ
cord-350992-l6l24pco	329	51	patients	patient	NNS
cord-350992-l6l24pco	329	52	with	with	IN
cord-350992-l6l24pco	329	53	at	at	RB
cord-350992-l6l24pco	329	54	least	least	JJS
cord-350992-l6l24pco	329	55	a	a	DT
cord-350992-l6l24pco	329	56	six	six	CD
cord-350992-l6l24pco	329	57	-	-	HYPH
cord-350992-l6l24pco	329	58	day	day	NN
cord-350992-l6l24pco	329	59	follow	follow	VB
cord-350992-l6l24pco	329	60	up	up	RP
cord-350992-l6l24pco	330	1	:	:	:
cord-350992-l6l24pco	330	2	A	a	DT
cord-350992-l6l24pco	330	3	pilot	pilot	NN
cord-350992-l6l24pco	330	4	observational	observational	JJ
cord-350992-l6l24pco	330	5	study	study	NN
cord-350992-l6l24pco	331	1	No	no	DT
cord-350992-l6l24pco	331	2	Evidence	evidence	NN
cord-350992-l6l24pco	331	3	of	of	IN
cord-350992-l6l24pco	331	4	Rapid	Rapid	NNP
cord-350992-l6l24pco	331	5	Antiviral	Antiviral	NNP
cord-350992-l6l24pco	331	6	Clearance	Clearance	NNP
cord-350992-l6l24pco	331	7	or	or	CC
cord-350992-l6l24pco	331	8	Clinical	Clinical	NNP
cord-350992-l6l24pco	331	9	Benefit	Benefit	NNP
cord-350992-l6l24pco	331	10	with	with	IN
cord-350992-l6l24pco	331	11	the	the	DT
cord-350992-l6l24pco	331	12	Combination	Combination	NNP
cord-350992-l6l24pco	331	13	of	of	IN
cord-350992-l6l24pco	331	14	Hydroxychloroquine	Hydroxychloroquine	NNP
cord-350992-l6l24pco	331	15	and	and	CC
cord-350992-l6l24pco	331	16	Azithromycin	Azithromycin	NNP
cord-350992-l6l24pco	331	17	in	in	IN
cord-350992-l6l24pco	331	18	Patients	patient	NNS
cord-350992-l6l24pco	331	19	with	with	IN
cord-350992-l6l24pco	331	20	Severe	severe	JJ
cord-350992-l6l24pco	331	21	COVID-19	COVID-19	NNP
cord-350992-l6l24pco	331	22	Infection	Infection	NNP
cord-350992-l6l24pco	331	23	Towards	towards	IN
cord-350992-l6l24pco	331	24	Optimization	Optimization	NNP
cord-350992-l6l24pco	331	25	of	of	IN
cord-350992-l6l24pco	331	26	Hydroxychloroquine	Hydroxychloroquine	NNP
cord-350992-l6l24pco	331	27	Dosing	Dosing	NNP
cord-350992-l6l24pco	331	28	in	in	IN
cord-350992-l6l24pco	331	29	Intensive	Intensive	NNP
cord-350992-l6l24pco	331	30	Care	Care	NNP
cord-350992-l6l24pco	331	31	Unit	Unit	NNP
cord-350992-l6l24pco	331	32	COVID-19	COVID-19	NNP
cord-350992-l6l24pco	331	33	Patients	Patients	NNPS
cord-350992-l6l24pco	331	34	of	of	IN
cord-350992-l6l24pco	331	35	the	the	DT
cord-350992-l6l24pco	331	36	N	n	CD
cord-350992-l6l24pco	331	37	-	-	HYPH
cord-350992-l6l24pco	331	38	glycosylation	glycosylation	NN
cord-350992-l6l24pco	331	39	of	of	IN
cord-350992-l6l24pco	331	40	the	the	DT
cord-350992-l6l24pco	331	41	cell	cell	NN
cord-350992-l6l24pco	331	42	surface	surface	NN
cord-350992-l6l24pco	331	43	viral	viral	JJ
cord-350992-l6l24pco	331	44	receptor	receptor	NN
cord-350992-l6l24pco	331	45	ACE2	ACE2	NNP
cord-350992-l6l24pco	331	46			CD
cord-350992-l6l24pco	331	47	inhibition	inhibition	NN
cord-350992-l6l24pco	331	48	of	of	IN
cord-350992-l6l24pco	331	49	the	the	DT
cord-350992-l6l24pco	331	50	N	n	CD
cord-350992-l6l24pco	331	51	-	-	HYPH
cord-350992-l6l24pco	331	52	glycosylation	glycosylation	NN
cord-350992-l6l24pco	331	53	of	of	IN
cord-350992-l6l24pco	331	54	the	the	DT
cord-350992-l6l24pco	331	55	viral	viral	JJ
cord-350992-l6l24pco	331	56	spike	spike	NN
cord-350992-l6l24pco	331	57	(	(	-LRB-
cord-350992-l6l24pco	331	58	S	s	NN
cord-350992-l6l24pco	331	59	)	)	-RRB-
cord-350992-l6l24pco	331	60	proteins	protein	VBZ
cord-350992-l6l24pco	331	61			CD
cord-350992-l6l24pco	331	62	inhibition	inhibition	NN
cord-350992-l6l24pco	331	63	of	of	IN
cord-350992-l6l24pco	331	64	the	the	DT
cord-350992-l6l24pco	331	65	synthesis	synthesis	NN
cord-350992-l6l24pco	331	66	of	of	IN
cord-350992-l6l24pco	331	67	cell	cell	NN
cord-350992-l6l24pco	331	68	membrane	membrane	NN
cord-350992-l6l24pco	331	69	sialic	sialic	NN
cord-350992-l6l24pco	331	70	acids	acid	NNS
cord-350992-l6l24pco	331	71			.
cord-350992-l6l24pco	332	1	Inhibition	inhibition	NN
cord-350992-l6l24pco	332	2	of	of	IN
cord-350992-l6l24pco	332	3	PICALM	PICALM	NNP
cord-350992-l6l24pco	332	4	expression	expression	NN
cord-350992-l6l24pco	332	5	,	,	,
cord-350992-l6l24pco	332	6	CME	CME	NNP
cord-350992-l6l24pco	332	7	and	and	CC
cord-350992-l6l24pco	332	8	pathogen	pathogen	NN
cord-350992-l6l24pco	332	9	internalization	internalization	NN
cord-350992-l6l24pco	332	10			.
cord-350992-l6l24pco	333	1	Vesicle	Vesicle	NNP
cord-350992-l6l24pco	333	2	alkalinization	alkalinization	NN
cord-350992-l6l24pco	333	3	and	and	CC
cord-350992-l6l24pco	333	4	inhibition	inhibition	NN
cord-350992-l6l24pco	333	5	of	of	IN
cord-350992-l6l24pco	333	6	endosomal	endosomal	NNP
cord-350992-l6l24pco	333	7	/	/	SYM
cord-350992-l6l24pco	333	8	lysosomal	lysosomal	JJ
cord-350992-l6l24pco	333	9	antigen	antigen	NN
cord-350992-l6l24pco	333	10	processing	processing	NN
cord-350992-l6l24pco	333	11			:
cord-350992-l6l24pco	333	12	Vesicle	Vesicle	NNP
cord-350992-l6l24pco	333	13	alkalinization	alkalinization	NN
cord-350992-l6l24pco	333	14	and	and	CC
cord-350992-l6l24pco	333	15	inhibition	inhibition	NN
cord-350992-l6l24pco	333	16	of	of	IN
cord-350992-l6l24pco	333	17	MHC	MHC	NNP
cord-350992-l6l24pco	333	18	processing	processing	NN
cord-350992-l6l24pco	333	19	and	and	CC
cord-350992-l6l24pco	333	20	MHC	MHC	NNP
cord-350992-l6l24pco	333	21	-	-	HYPH
cord-350992-l6l24pco	333	22	antigen	antigen	NNP
cord-350992-l6l24pco	333	23	We	-PRON-	PRP
cord-350992-l6l24pco	333	24	would	would	MD
cord-350992-l6l24pco	333	25	like	like	VB
cord-350992-l6l24pco	333	26	to	to	TO
cord-350992-l6l24pco	333	27	thank	thank	VB
cord-350992-l6l24pco	333	28	Andrea	Andrea	NNP
cord-350992-l6l24pco	333	29	Zanella	Zanella	NNP
cord-350992-l6l24pco	333	30	for	for	IN
cord-350992-l6l24pco	333	31	helpful	helpful	JJ
cord-350992-l6l24pco	333	32	language	language	NN
cord-350992-l6l24pco	333	33	editing	editing	NN
cord-350992-l6l24pco	333	34	.	.	.
cord-350992-l6l24pco	334	1	Isabella	Isabella	NNP
cord-350992-l6l24pco	334	2	Zanella	Zanella	NNP
cord-350992-l6l24pco	334	3	wishes	wish	VBZ
cord-350992-l6l24pco	334	4	to	to	TO
cord-350992-l6l24pco	334	5	dedicate	dedicate	VB
cord-350992-l6l24pco	334	6	this	this	DT
cord-350992-l6l24pco	334	7	work	work	NN
cord-350992-l6l24pco	334	8	to	to	IN
cord-350992-l6l24pco	334	9	her	-PRON-	PRP$
cord-350992-l6l24pco	334	10	father	father	NN
cord-350992-l6l24pco	334	11	,	,	,
cord-350992-l6l24pco	334	12	Antonio	Antonio	NNP
cord-350992-l6l24pco	334	13	Zanella	Zanella	NNP
cord-350992-l6l24pco	334	14	,	,	,
cord-350992-l6l24pco	334	15	who	who	WP
cord-350992-l6l24pco	334	16	recently	recently	RB
cord-350992-l6l24pco	334	17	died	die	VBD
cord-350992-l6l24pco	334	18	for	for	IN
cord-350992-l6l24pco	334	19	COVID-19.Due	COVID-19.Due	NNS
cord-350992-l6l24pco	334	20	to	to	IN
cord-350992-l6l24pco	334	21	space	space	NN
cord-350992-l6l24pco	334	22	constraints	constraint	NNS
cord-350992-l6l24pco	334	23	,	,	,
cord-350992-l6l24pco	334	24	we	-PRON-	PRP
cord-350992-l6l24pco	334	25	were	be	VBD
cord-350992-l6l24pco	334	26	unable	unable	JJ
cord-350992-l6l24pco	334	27	to	to	TO
cord-350992-l6l24pco	334	28	provide	provide	VB
cord-350992-l6l24pco	334	29	a	a	DT
cord-350992-l6l24pco	334	30	comprehensive	comprehensive	JJ
cord-350992-l6l24pco	334	31	citation	citation	NN
cord-350992-l6l24pco	334	32	of	of	IN
cord-350992-l6l24pco	334	33	all	all	PDT
cord-350992-l6l24pco	334	34	the	the	DT
cord-350992-l6l24pco	334	35	relevant	relevant	JJ
cord-350992-l6l24pco	334	36	primary	primary	JJ
cord-350992-l6l24pco	334	37	literature	literature	NN
cord-350992-l6l24pco	334	38	.	.	.
cord-350992-l6l24pco	335	1	We	-PRON-	PRP
cord-350992-l6l24pco	335	2	apologize	apologize	VBP
cord-350992-l6l24pco	335	3	to	to	IN
cord-350992-l6l24pco	335	4	those	those	DT
cord-350992-l6l24pco	335	5	whom	whom	WP
cord-350992-l6l24pco	335	6	we	-PRON-	PRP
cord-350992-l6l24pco	335	7	have	have	VBP
cord-350992-l6l24pco	335	8	even	even	RB
cord-350992-l6l24pco	335	9	unintentionally	unintentionally	RB
cord-350992-l6l24pco	335	10	omitted	omit	VBN
cord-350992-l6l24pco	335	11	.	.	.
cord-350992-l6l24pco	336	1	J	J	NNP
cord-350992-l6l24pco	336	2	o	o	NN
cord-350992-l6l24pco	336	3	u	u	NN
cord-350992-l6l24pco	336	4	r	r	NN
cord-350992-l6l24pco	336	5	n	n	NN
cord-350992-l6l24pco	336	6	a	a	DT
cord-350992-l6l24pco	336	7	l	l	NN
cord-350992-l6l24pco	336	8	P	p	NN
cord-350992-l6l24pco	336	9	r	r	NN
cord-350992-l6l24pco	336	10	e	e	NN
cord-350992-l6l24pco	336	11	-p	-p	NN
cord-350992-l6l24pco	337	1	r	r	LS
cord-350992-l6l24pco	338	1	o	o	UH
cord-350992-l6l24pco	338	2	o	o	NN
cord-350992-l6l24pco	338	3	f	f	NN