id sid tid token lemma pos cord-348535-tvs1snq8 1 1 key key JJ cord-348535-tvs1snq8 1 2 : : : cord-348535-tvs1snq8 1 3 cord-348535-tvs1snq8 cord-348535-tvs1snq8 NNS cord-348535-tvs1snq8 1 4 authors author NNS cord-348535-tvs1snq8 1 5 : : : cord-348535-tvs1snq8 1 6 Ottaviani Ottaviani NNP cord-348535-tvs1snq8 1 7 , , , cord-348535-tvs1snq8 1 8 Silvia Silvia NNP cord-348535-tvs1snq8 1 9 ; ; : cord-348535-tvs1snq8 1 10 Stebbing Stebbing NNP cord-348535-tvs1snq8 1 11 , , , cord-348535-tvs1snq8 2 1 Justin Justin NNP cord-348535-tvs1snq8 2 2 title title NN cord-348535-tvs1snq8 3 1 : : : cord-348535-tvs1snq8 3 2 What what WP cord-348535-tvs1snq8 3 3 is be VBZ cord-348535-tvs1snq8 3 4 the the DT cord-348535-tvs1snq8 3 5 best good JJS cord-348535-tvs1snq8 3 6 drug drug NN cord-348535-tvs1snq8 3 7 to to TO cord-348535-tvs1snq8 3 8 treat treat VB cord-348535-tvs1snq8 3 9 COVID-19 COVID-19 NNP cord-348535-tvs1snq8 3 10 ? ? . cord-348535-tvs1snq8 4 1 The the DT cord-348535-tvs1snq8 4 2 need need NN cord-348535-tvs1snq8 4 3 for for IN cord-348535-tvs1snq8 4 4 randomized randomized JJ cord-348535-tvs1snq8 4 5 controlled control VBN cord-348535-tvs1snq8 4 6 trials trial NNS cord-348535-tvs1snq8 4 7 date date NN cord-348535-tvs1snq8 4 8 : : : cord-348535-tvs1snq8 4 9 2020 2020 CD cord-348535-tvs1snq8 4 10 - - HYPH cord-348535-tvs1snq8 4 11 05 05 CD cord-348535-tvs1snq8 4 12 - - HYPH cord-348535-tvs1snq8 4 13 19 19 CD cord-348535-tvs1snq8 4 14 journal journal NN cord-348535-tvs1snq8 4 15 : : : cord-348535-tvs1snq8 4 16 Med Med NNP cord-348535-tvs1snq8 4 17 DOI DOI NNP cord-348535-tvs1snq8 4 18 : : : cord-348535-tvs1snq8 4 19 10.1016 10.1016 CD cord-348535-tvs1snq8 4 20 / / SYM cord-348535-tvs1snq8 4 21 j.medj.2020.04.002 j.medj.2020.04.002 CD cord-348535-tvs1snq8 4 22 sha sha NNP cord-348535-tvs1snq8 4 23 : : : cord-348535-tvs1snq8 4 24 0870860be5ab23ff1152be285f7490e638fbf22c 0870860be5ab23ff1152be285f7490e638fbf22c CD cord-348535-tvs1snq8 4 25 doc_id doc_id CD cord-348535-tvs1snq8 4 26 : : : cord-348535-tvs1snq8 4 27 348535 348535 CD cord-348535-tvs1snq8 4 28 cord_uid cord_uid NNS cord-348535-tvs1snq8 4 29 : : : cord-348535-tvs1snq8 4 30 tvs1snq8 tvs1snq8 NNP cord-348535-tvs1snq8 5 1 The the DT cord-348535-tvs1snq8 5 2 severe severe JJ cord-348535-tvs1snq8 5 3 acute acute JJ cord-348535-tvs1snq8 5 4 respiratory respiratory JJ cord-348535-tvs1snq8 5 5 syndrome syndrome NN cord-348535-tvs1snq8 5 6 coronavirus coronavirus NN cord-348535-tvs1snq8 5 7 2 2 CD cord-348535-tvs1snq8 6 1 ( ( -LRB- cord-348535-tvs1snq8 6 2 SARS SARS NNP cord-348535-tvs1snq8 6 3 - - HYPH cord-348535-tvs1snq8 6 4 CoV-2 CoV-2 NNP cord-348535-tvs1snq8 6 5 ) ) -RRB- cord-348535-tvs1snq8 6 6 is be VBZ cord-348535-tvs1snq8 6 7 currently currently RB cord-348535-tvs1snq8 6 8 the the DT cord-348535-tvs1snq8 6 9 biggest big JJS cord-348535-tvs1snq8 6 10 public public JJ cord-348535-tvs1snq8 6 11 health health NN cord-348535-tvs1snq8 6 12 challenge challenge NN cord-348535-tvs1snq8 6 13 to to IN cord-348535-tvs1snq8 6 14 the the DT cord-348535-tvs1snq8 6 15 biomedical biomedical JJ cord-348535-tvs1snq8 6 16 community community NN cord-348535-tvs1snq8 6 17 of of IN cord-348535-tvs1snq8 6 18 the the DT cord-348535-tvs1snq8 6 19 last last JJ cord-348535-tvs1snq8 6 20 century century NN cord-348535-tvs1snq8 6 21 . . . cord-348535-tvs1snq8 7 1 Despite despite IN cord-348535-tvs1snq8 7 2 multiple multiple JJ cord-348535-tvs1snq8 7 3 public public JJ cord-348535-tvs1snq8 7 4 health health NN cord-348535-tvs1snq8 7 5 measures,1 measures,1 CD cord-348535-tvs1snq8 7 6 , , , cord-348535-tvs1snq8 7 7 2 2 CD cord-348535-tvs1snq8 7 8 , , , cord-348535-tvs1snq8 7 9 3 3 CD cord-348535-tvs1snq8 7 10 there there EX cord-348535-tvs1snq8 7 11 remains remain VBZ cord-348535-tvs1snq8 7 12 an an DT cord-348535-tvs1snq8 7 13 urgent urgent JJ cord-348535-tvs1snq8 7 14 need need NN cord-348535-tvs1snq8 7 15 for for IN cord-348535-tvs1snq8 7 16 pharmacologic pharmacologic JJ cord-348535-tvs1snq8 7 17 therapies therapy NNS cord-348535-tvs1snq8 7 18 to to TO cord-348535-tvs1snq8 7 19 treat treat VB cord-348535-tvs1snq8 7 20 infected infected JJ cord-348535-tvs1snq8 7 21 patients patient NNS cord-348535-tvs1snq8 7 22 , , , cord-348535-tvs1snq8 7 23 minimize minimize VB cord-348535-tvs1snq8 7 24 mortality mortality NN cord-348535-tvs1snq8 7 25 , , , cord-348535-tvs1snq8 7 26 and and CC cord-348535-tvs1snq8 7 27 decrease decrease VB cord-348535-tvs1snq8 7 28 pressures pressure NNS cord-348535-tvs1snq8 7 29 on on IN cord-348535-tvs1snq8 7 30 intensive intensive JJ cord-348535-tvs1snq8 7 31 care care NN cord-348535-tvs1snq8 7 32 units unit NNS cord-348535-tvs1snq8 7 33 and and CC cord-348535-tvs1snq8 7 34 health health NN cord-348535-tvs1snq8 7 35 systems system NNS cord-348535-tvs1snq8 7 36 and and CC cord-348535-tvs1snq8 7 37 optimally optimally RB cord-348535-tvs1snq8 7 38 , , , cord-348535-tvs1snq8 7 39 they -PRON- PRP cord-348535-tvs1snq8 7 40 should should MD cord-348535-tvs1snq8 7 41 also also RB cord-348535-tvs1snq8 7 42 decrease decrease VB cord-348535-tvs1snq8 7 43 subsequent subsequent JJ cord-348535-tvs1snq8 7 44 transmission transmission NN cord-348535-tvs1snq8 7 45 . . . cord-348535-tvs1snq8 8 1 The the DT cord-348535-tvs1snq8 8 2 severe severe JJ cord-348535-tvs1snq8 8 3 acute acute JJ cord-348535-tvs1snq8 8 4 respiratory respiratory JJ cord-348535-tvs1snq8 8 5 syndrome syndrome NN cord-348535-tvs1snq8 8 6 coronavirus coronavirus NN cord-348535-tvs1snq8 8 7 2 2 CD cord-348535-tvs1snq8 9 1 ( ( -LRB- cord-348535-tvs1snq8 9 2 SARS SARS NNP cord-348535-tvs1snq8 9 3 - - HYPH cord-348535-tvs1snq8 9 4 CoV-2 CoV-2 NNP cord-348535-tvs1snq8 9 5 ) ) -RRB- cord-348535-tvs1snq8 9 6 is be VBZ cord-348535-tvs1snq8 9 7 currently currently RB cord-348535-tvs1snq8 9 8 the the DT cord-348535-tvs1snq8 9 9 biggest big JJS cord-348535-tvs1snq8 9 10 public public JJ cord-348535-tvs1snq8 9 11 health health NN cord-348535-tvs1snq8 9 12 challenge challenge NN cord-348535-tvs1snq8 9 13 to to IN cord-348535-tvs1snq8 9 14 the the DT cord-348535-tvs1snq8 9 15 biomedical biomedical JJ cord-348535-tvs1snq8 9 16 community community NN cord-348535-tvs1snq8 9 17 of of IN cord-348535-tvs1snq8 9 18 the the DT cord-348535-tvs1snq8 9 19 last last JJ cord-348535-tvs1snq8 9 20 century century NN cord-348535-tvs1snq8 9 21 . . . cord-348535-tvs1snq8 10 1 Despite despite IN cord-348535-tvs1snq8 10 2 multiple multiple JJ cord-348535-tvs1snq8 10 3 public public JJ cord-348535-tvs1snq8 10 4 health health NN cord-348535-tvs1snq8 10 5 measures measure NNS cord-348535-tvs1snq8 10 6 , , , cord-348535-tvs1snq8 10 7 1 1 CD cord-348535-tvs1snq8 10 8 - - SYM cord-348535-tvs1snq8 10 9 3 3 CD cord-348535-tvs1snq8 10 10 there there EX cord-348535-tvs1snq8 10 11 remains remain VBZ cord-348535-tvs1snq8 10 12 an an DT cord-348535-tvs1snq8 10 13 urgent urgent JJ cord-348535-tvs1snq8 10 14 need need NN cord-348535-tvs1snq8 10 15 for for IN cord-348535-tvs1snq8 10 16 pharmacologic pharmacologic JJ cord-348535-tvs1snq8 10 17 therapies therapy NNS cord-348535-tvs1snq8 10 18 to to TO cord-348535-tvs1snq8 10 19 treat treat VB cord-348535-tvs1snq8 10 20 infected infected JJ cord-348535-tvs1snq8 10 21 patients patient NNS cord-348535-tvs1snq8 10 22 and and CC cord-348535-tvs1snq8 10 23 minimize minimize VB cord-348535-tvs1snq8 10 24 mortality mortality NN cord-348535-tvs1snq8 10 25 , , , cord-348535-tvs1snq8 10 26 decrease decrease VB cord-348535-tvs1snq8 10 27 pressures pressure NNS cord-348535-tvs1snq8 10 28 on on IN cord-348535-tvs1snq8 10 29 intensive intensive JJ cord-348535-tvs1snq8 10 30 care care NN cord-348535-tvs1snq8 10 31 units unit NNS cord-348535-tvs1snq8 10 32 and and CC cord-348535-tvs1snq8 10 33 health health NN cord-348535-tvs1snq8 10 34 systems system NNS cord-348535-tvs1snq8 10 35 and and CC cord-348535-tvs1snq8 10 36 optimally optimally RB cord-348535-tvs1snq8 10 37 they -PRON- PRP cord-348535-tvs1snq8 10 38 should should MD cord-348535-tvs1snq8 10 39 decrease decrease VB cord-348535-tvs1snq8 10 40 subsequent subsequent JJ cord-348535-tvs1snq8 10 41 transmission transmission NN cord-348535-tvs1snq8 10 42 . . . cord-348535-tvs1snq8 11 1 At at IN cord-348535-tvs1snq8 11 2 the the DT cord-348535-tvs1snq8 11 3 time time NN cord-348535-tvs1snq8 11 4 of of IN cord-348535-tvs1snq8 11 5 writing writing NN cord-348535-tvs1snq8 11 6 , , , cord-348535-tvs1snq8 11 7 there there EX cord-348535-tvs1snq8 11 8 are be VBP cord-348535-tvs1snq8 11 9 no no DT cord-348535-tvs1snq8 11 10 licensed licensed JJ cord-348535-tvs1snq8 11 11 drugs drug NNS cord-348535-tvs1snq8 11 12 to to TO cord-348535-tvs1snq8 11 13 treat treat VB cord-348535-tvs1snq8 11 14 COVID-19 COVID-19 NNP cord-348535-tvs1snq8 11 15 and and CC cord-348535-tvs1snq8 11 16 a a DT cord-348535-tvs1snq8 11 17 search search NN cord-348535-tvs1snq8 11 18 on on IN cord-348535-tvs1snq8 11 19 clinicaltrials.gov clinicaltrials.gov NNP cord-348535-tvs1snq8 11 20 using use VBG cord-348535-tvs1snq8 11 21 ' ' `` cord-348535-tvs1snq8 11 22 COVID-19 covid-19 NN cord-348535-tvs1snq8 11 23 ' ' '' cord-348535-tvs1snq8 11 24 as as IN cord-348535-tvs1snq8 11 25 the the DT cord-348535-tvs1snq8 11 26 input input NN cord-348535-tvs1snq8 11 27 term term NN cord-348535-tvs1snq8 11 28 , , , cord-348535-tvs1snq8 11 29 yielded yield VBD cord-348535-tvs1snq8 11 30 657 657 CD cord-348535-tvs1snq8 11 31 studies study NNS cord-348535-tvs1snq8 11 32 . . . cord-348535-tvs1snq8 12 1 Drug drug NN cord-348535-tvs1snq8 12 2 - - HYPH cord-348535-tvs1snq8 12 3 based base VBN cord-348535-tvs1snq8 12 4 interventions intervention NNS cord-348535-tvs1snq8 12 5 currently currently RB cord-348535-tvs1snq8 12 6 fall fall VBP cord-348535-tvs1snq8 12 7 into into IN cord-348535-tvs1snq8 12 8 categories category NNS cord-348535-tvs1snq8 12 9 including include VBG cord-348535-tvs1snq8 12 10 off off RP cord-348535-tvs1snq8 12 11 label label NN cord-348535-tvs1snq8 12 12 use use NN cord-348535-tvs1snq8 12 13 which which WDT cord-348535-tvs1snq8 12 14 includes include VBZ cord-348535-tvs1snq8 12 15 repurposed repurpose VBN cord-348535-tvs1snq8 12 16 drugs drug NNS cord-348535-tvs1snq8 12 17 , , , cord-348535-tvs1snq8 12 18 4,5 4,5 CD cord-348535-tvs1snq8 12 19 and and CC cord-348535-tvs1snq8 12 20 newer new JJR cord-348535-tvs1snq8 12 21 entities entity NNS cord-348535-tvs1snq8 12 22 but but CC cord-348535-tvs1snq8 12 23 both both DT cord-348535-tvs1snq8 12 24 categories category NNS cord-348535-tvs1snq8 12 25 should should MD cord-348535-tvs1snq8 12 26 be be VB cord-348535-tvs1snq8 12 27 given give VBN cord-348535-tvs1snq8 12 28 in in IN cord-348535-tvs1snq8 12 29 the the DT cord-348535-tvs1snq8 12 30 context context NN cord-348535-tvs1snq8 12 31 of of IN cord-348535-tvs1snq8 12 32 clinical clinical JJ cord-348535-tvs1snq8 12 33 trials trial NNS cord-348535-tvs1snq8 12 34 . . . cord-348535-tvs1snq8 13 1 In in IN cord-348535-tvs1snq8 13 2 Wuhan Wuhan NNP cord-348535-tvs1snq8 13 3 , , , cord-348535-tvs1snq8 13 4 China China NNP cord-348535-tvs1snq8 13 5 , , , cord-348535-tvs1snq8 13 6 then then RB cord-348535-tvs1snq8 13 7 the the DT cord-348535-tvs1snq8 13 8 epicentre epicentre NN cord-348535-tvs1snq8 13 9 of of IN cord-348535-tvs1snq8 13 10 the the DT cord-348535-tvs1snq8 13 11 pandemic pandemic NN cord-348535-tvs1snq8 13 12 , , , cord-348535-tvs1snq8 13 13 Cao Cao NNP cord-348535-tvs1snq8 13 14 et et NNP cord-348535-tvs1snq8 13 15 al al NNP cord-348535-tvs1snq8 13 16 . . . cord-348535-tvs1snq8 14 1 under under IN cord-348535-tvs1snq8 14 2 heroic heroic JJ cord-348535-tvs1snq8 14 3 circumstances circumstance NNS cord-348535-tvs1snq8 14 4 , , , cord-348535-tvs1snq8 14 5 conducted conduct VBD cord-348535-tvs1snq8 14 6 a a DT cord-348535-tvs1snq8 14 7 randomized randomize VBN cord-348535-tvs1snq8 14 8 , , , cord-348535-tvs1snq8 14 9 controlled control VBN cord-348535-tvs1snq8 14 10 , , , cord-348535-tvs1snq8 14 11 open open JJ cord-348535-tvs1snq8 14 12 - - HYPH cord-348535-tvs1snq8 14 13 label label NN cord-348535-tvs1snq8 14 14 trial trial NN cord-348535-tvs1snq8 14 15 involving involve VBG cord-348535-tvs1snq8 14 16 199 199 CD cord-348535-tvs1snq8 14 17 hospitalized hospitalize VBN cord-348535-tvs1snq8 14 18 patients patient NNS cord-348535-tvs1snq8 14 19 with with IN cord-348535-tvs1snq8 14 20 confirmed confirm VBN cord-348535-tvs1snq8 14 21 SARS SARS NNP cord-348535-tvs1snq8 14 22 - - HYPH cord-348535-tvs1snq8 14 23 CoV-2 CoV-2 NNP cord-348535-tvs1snq8 14 24 infection infection NN cord-348535-tvs1snq8 14 25 including include VBG cord-348535-tvs1snq8 14 26 as as IN cord-348535-tvs1snq8 14 27 an an DT cord-348535-tvs1snq8 14 28 entry entry NN cord-348535-tvs1snq8 14 29 criteria criteria VBZ cord-348535-tvs1snq8 14 30 oxygen oxygen NN cord-348535-tvs1snq8 14 31 saturation saturation NN cord-348535-tvs1snq8 14 32 ( ( -LRB- cord-348535-tvs1snq8 14 33 SaO2 SaO2 NNS cord-348535-tvs1snq8 14 34 ) ) -RRB- cord-348535-tvs1snq8 14 35 of of IN cord-348535-tvs1snq8 14 36 94 94 CD cord-348535-tvs1snq8 14 37 % % NN cord-348535-tvs1snq8 14 38 or or CC cord-348535-tvs1snq8 14 39 less less JJR cord-348535-tvs1snq8 14 40 on on IN cord-348535-tvs1snq8 14 41 air air NN cord-348535-tvs1snq8 14 42 ( ( -LRB- cord-348535-tvs1snq8 14 43 ChiCTR2000029308 ChiCTR2000029308 NNP cord-348535-tvs1snq8 14 44 ) ) -RRB- cord-348535-tvs1snq8 14 45 . . . cord-348535-tvs1snq8 15 1 Patients patient NNS cord-348535-tvs1snq8 15 2 were be VBD cord-348535-tvs1snq8 15 3 randomly randomly RB cord-348535-tvs1snq8 15 4 assigned assign VBN cord-348535-tvs1snq8 15 5 1:1 1:1 CD cord-348535-tvs1snq8 15 6 to to TO cord-348535-tvs1snq8 15 7 receive receive VB cord-348535-tvs1snq8 15 8 either either DT cord-348535-tvs1snq8 15 9 lopinavir lopinavir NNS cord-348535-tvs1snq8 15 10 - - HYPH cord-348535-tvs1snq8 15 11 ritonavir ritonavir NNP cord-348535-tvs1snq8 15 12 ( ( -LRB- cord-348535-tvs1snq8 15 13 400 400 CD cord-348535-tvs1snq8 15 14 mg mg NN cord-348535-tvs1snq8 15 15 and and CC cord-348535-tvs1snq8 15 16 100 100 CD cord-348535-tvs1snq8 15 17 mg mg NNS cord-348535-tvs1snq8 15 18 , , , cord-348535-tvs1snq8 15 19 respectively respectively RB cord-348535-tvs1snq8 15 20 ) ) -RRB- cord-348535-tvs1snq8 15 21 twice twice RB cord-348535-tvs1snq8 15 22 daily daily RB cord-348535-tvs1snq8 15 23 for for IN cord-348535-tvs1snq8 15 24 14 14 CD cord-348535-tvs1snq8 15 25 days day NNS cord-348535-tvs1snq8 15 26 , , , cord-348535-tvs1snq8 15 27 or or CC cord-348535-tvs1snq8 15 28 standard standard JJ cord-348535-tvs1snq8 15 29 care care NN cord-348535-tvs1snq8 15 30 alone alone RB cord-348535-tvs1snq8 15 31 . . . cord-348535-tvs1snq8 16 1 The the DT cord-348535-tvs1snq8 16 2 primary primary JJ cord-348535-tvs1snq8 16 3 end end NN cord-348535-tvs1snq8 16 4 point point NN cord-348535-tvs1snq8 16 5 was be VBD cord-348535-tvs1snq8 16 6 the the DT cord-348535-tvs1snq8 16 7 time time NN cord-348535-tvs1snq8 16 8 to to IN cord-348535-tvs1snq8 16 9 clinical clinical JJ cord-348535-tvs1snq8 16 10 improvement improvement NN cord-348535-tvs1snq8 16 11 , , , cord-348535-tvs1snq8 16 12 defined define VBN cord-348535-tvs1snq8 16 13 as as IN cord-348535-tvs1snq8 16 14 the the DT cord-348535-tvs1snq8 16 15 time time NN cord-348535-tvs1snq8 16 16 from from IN cord-348535-tvs1snq8 16 17 randomization randomization NN cord-348535-tvs1snq8 16 18 to to IN cord-348535-tvs1snq8 16 19 either either CC cord-348535-tvs1snq8 16 20 an an DT cord-348535-tvs1snq8 16 21 improvement improvement NN cord-348535-tvs1snq8 16 22 of of IN cord-348535-tvs1snq8 16 23 two two CD cord-348535-tvs1snq8 16 24 points point NNS cord-348535-tvs1snq8 16 25 on on IN cord-348535-tvs1snq8 16 26 a a DT cord-348535-tvs1snq8 16 27 seven seven CD cord-348535-tvs1snq8 16 28 - - HYPH cord-348535-tvs1snq8 16 29 category category NN cord-348535-tvs1snq8 16 30 ordinal ordinal JJ cord-348535-tvs1snq8 16 31 scale scale NN cord-348535-tvs1snq8 16 32 or or CC cord-348535-tvs1snq8 16 33 discharge discharge NN cord-348535-tvs1snq8 16 34 from from IN cord-348535-tvs1snq8 16 35 the the DT cord-348535-tvs1snq8 16 36 hospital hospital NN cord-348535-tvs1snq8 16 37 , , , cord-348535-tvs1snq8 16 38 whichever whichever WDT cord-348535-tvs1snq8 16 39 came come VBD cord-348535-tvs1snq8 16 40 first first RB cord-348535-tvs1snq8 16 41 . . . cord-348535-tvs1snq8 17 1 6 6 CD cord-348535-tvs1snq8 18 1 Even even RB cord-348535-tvs1snq8 18 2 though though IN cord-348535-tvs1snq8 18 3 their -PRON- PRP$ cord-348535-tvs1snq8 18 4 study study NN cord-348535-tvs1snq8 18 5 showed show VBD cord-348535-tvs1snq8 18 6 no no DT cord-348535-tvs1snq8 18 7 benefits benefit NNS cord-348535-tvs1snq8 18 8 with with IN cord-348535-tvs1snq8 18 9 lopinavir lopinavir NNS cord-348535-tvs1snq8 18 10 - - HYPH cord-348535-tvs1snq8 18 11 ritonavir ritonavir NNP cord-348535-tvs1snq8 18 12 treatment treatment NN cord-348535-tvs1snq8 18 13 beyond beyond IN cord-348535-tvs1snq8 18 14 standard standard JJ cord-348535-tvs1snq8 18 15 care care NN cord-348535-tvs1snq8 18 16 , , , cord-348535-tvs1snq8 18 17 this this DT cord-348535-tvs1snq8 18 18 is be VBZ cord-348535-tvs1snq8 18 19 exactly exactly RB cord-348535-tvs1snq8 18 20 the the DT cord-348535-tvs1snq8 18 21 sort sort NN cord-348535-tvs1snq8 18 22 of of IN cord-348535-tvs1snq8 18 23 study study NN cord-348535-tvs1snq8 18 24 that that IN cord-348535-tvs1snq8 18 25 best well RBS cord-348535-tvs1snq8 18 26 informs inform VBZ cord-348535-tvs1snq8 18 27 our -PRON- PRP$ cord-348535-tvs1snq8 18 28 treatment treatment NN cord-348535-tvs1snq8 18 29 options option NNS cord-348535-tvs1snq8 18 30 . . . cord-348535-tvs1snq8 19 1 Following follow VBG cord-348535-tvs1snq8 19 2 this this DT cord-348535-tvs1snq8 19 3 , , , cord-348535-tvs1snq8 19 4 we -PRON- PRP cord-348535-tvs1snq8 19 5 were be VBD cord-348535-tvs1snq8 19 6 surprised surprised JJ cord-348535-tvs1snq8 19 7 to to TO cord-348535-tvs1snq8 19 8 see see VB cord-348535-tvs1snq8 19 9 the the DT cord-348535-tvs1snq8 19 10 New New NNP cord-348535-tvs1snq8 19 11 England England NNP cord-348535-tvs1snq8 19 12 Journal Journal NNP cord-348535-tvs1snq8 19 13 of of IN cord-348535-tvs1snq8 19 14 Medicine Medicine NNP cord-348535-tvs1snq8 19 15 publishing publish VBG cord-348535-tvs1snq8 19 16 a a DT cord-348535-tvs1snq8 19 17 single single JJ cord-348535-tvs1snq8 19 18 arm arm NN cord-348535-tvs1snq8 19 19 study study NN cord-348535-tvs1snq8 19 20 on on IN cord-348535-tvs1snq8 19 21 61 61 CD cord-348535-tvs1snq8 19 22 patients patient NNS cord-348535-tvs1snq8 19 23 who who WP cord-348535-tvs1snq8 19 24 received receive VBD cord-348535-tvs1snq8 19 25 at at IN cord-348535-tvs1snq8 19 26 least least RBS cord-348535-tvs1snq8 19 27 one one CD cord-348535-tvs1snq8 19 28 dose dose NN cord-348535-tvs1snq8 19 29 of of IN cord-348535-tvs1snq8 19 30 remdesevir remdesevir NNS cord-348535-tvs1snq8 19 31 , , , cord-348535-tvs1snq8 19 32 again again RB cord-348535-tvs1snq8 19 33 with with IN cord-348535-tvs1snq8 19 34 similar similar JJ cord-348535-tvs1snq8 19 35 entry entry NN cord-348535-tvs1snq8 19 36 criteria criterion NNS cord-348535-tvs1snq8 19 37 of of IN cord-348535-tvs1snq8 19 38 SaO2 SaO2 NNS cord-348535-tvs1snq8 19 39 < < XX cord-348535-tvs1snq8 19 40 94 94 CD cord-348535-tvs1snq8 19 41 % % NN cord-348535-tvs1snq8 19 42 on on IN cord-348535-tvs1snq8 19 43 air air NN cord-348535-tvs1snq8 19 44 . . . cord-348535-tvs1snq8 20 1 7 7 CD cord-348535-tvs1snq8 20 2 _SP cord-348535-tvs1snq8 21 1 One one PRP cord-348535-tvs1snq8 21 2 presumes presume VBZ cord-348535-tvs1snq8 21 3 that that IN cord-348535-tvs1snq8 21 4 the the DT cord-348535-tvs1snq8 21 5 patients patient NNS cord-348535-tvs1snq8 21 6 in in IN cord-348535-tvs1snq8 21 7 the the DT cord-348535-tvs1snq8 21 8 remdesevir remdesevir NNP cord-348535-tvs1snq8 21 9 single single JJ cord-348535-tvs1snq8 21 10 arm arm NN cord-348535-tvs1snq8 21 11 study study NN cord-348535-tvs1snq8 21 12 , , , cord-348535-tvs1snq8 21 13 and and CC cord-348535-tvs1snq8 21 14 several several JJ cord-348535-tvs1snq8 21 15 included include VBN cord-348535-tvs1snq8 21 16 in in IN cord-348535-tvs1snq8 21 17 an an DT cord-348535-tvs1snq8 21 18 earlier early JJR cord-348535-tvs1snq8 21 19 Lancet Lancet NNP cord-348535-tvs1snq8 21 20 paper paper NN cord-348535-tvs1snq8 21 21 , , , cord-348535-tvs1snq8 21 22 8 8 CD cord-348535-tvs1snq8 21 23 were be VBD cord-348535-tvs1snq8 21 24 recruited recruit VBN cord-348535-tvs1snq8 21 25 in in IN cord-348535-tvs1snq8 21 26 perhaps perhaps RB cord-348535-tvs1snq8 21 27 easier easy JJR cord-348535-tvs1snq8 21 28 conditions condition NNS cord-348535-tvs1snq8 21 29 than than IN cord-348535-tvs1snq8 21 30 those those DT cord-348535-tvs1snq8 21 31 in in IN cord-348535-tvs1snq8 21 32 Wuhan Wuhan NNP cord-348535-tvs1snq8 21 33 earlier early RBR cord-348535-tvs1snq8 21 34 this this DT cord-348535-tvs1snq8 21 35 year year NN cord-348535-tvs1snq8 21 36 . . . cord-348535-tvs1snq8 22 1 Randomised randomised JJ cord-348535-tvs1snq8 22 2 trials trial NNS cord-348535-tvs1snq8 22 3 are be VBP cord-348535-tvs1snq8 22 4 designed design VBN cord-348535-tvs1snq8 22 5 to to TO cord-348535-tvs1snq8 22 6 precisely precisely RB cord-348535-tvs1snq8 22 7 answer answer VB cord-348535-tvs1snq8 22 8 questions question NNS cord-348535-tvs1snq8 22 9 regarding regard VBG cord-348535-tvs1snq8 22 10 toxicity toxicity NN cord-348535-tvs1snq8 22 11 and and CC cord-348535-tvs1snq8 22 12 efficacy efficacy NN cord-348535-tvs1snq8 22 13 beyond beyond IN cord-348535-tvs1snq8 22 14 standard standard NN cord-348535-tvs1snq8 22 15 of of IN cord-348535-tvs1snq8 22 16 care care NN cord-348535-tvs1snq8 22 17 and and CC cord-348535-tvs1snq8 22 18 in in IN cord-348535-tvs1snq8 22 19 the the DT cord-348535-tvs1snq8 22 20 absence absence NN cord-348535-tvs1snq8 22 21 of of IN cord-348535-tvs1snq8 22 22 an an DT cord-348535-tvs1snq8 22 23 effective effective JJ cord-348535-tvs1snq8 22 24 therapy therapy NN cord-348535-tvs1snq8 22 25 it -PRON- PRP cord-348535-tvs1snq8 22 26 remains remain VBZ cord-348535-tvs1snq8 22 27 entirely entirely RB cord-348535-tvs1snq8 22 28 reasonable reasonable JJ cord-348535-tvs1snq8 22 29 and and CC cord-348535-tvs1snq8 22 30 ethical ethical JJ cord-348535-tvs1snq8 22 31 at at IN cord-348535-tvs1snq8 22 32 this this DT cord-348535-tvs1snq8 22 33 point point NN cord-348535-tvs1snq8 22 34 to to TO cord-348535-tvs1snq8 22 35 perform perform VB cord-348535-tvs1snq8 22 36 a a DT cord-348535-tvs1snq8 22 37 trial trial NN cord-348535-tvs1snq8 22 38 versus versus IN cord-348535-tvs1snq8 22 39 placebo placebo NN cord-348535-tvs1snq8 22 40 . . . cord-348535-tvs1snq8 23 1 They -PRON- PRP cord-348535-tvs1snq8 23 2 are be VBP cord-348535-tvs1snq8 23 3 much much RB cord-348535-tvs1snq8 23 4 more more RBR cord-348535-tvs1snq8 23 5 informative informative JJ cord-348535-tvs1snq8 23 6 than than IN cord-348535-tvs1snq8 23 7 single single JJ cord-348535-tvs1snq8 23 8 arm arm NN cord-348535-tvs1snq8 23 9 studies study NNS cord-348535-tvs1snq8 23 10 which which WDT cord-348535-tvs1snq8 23 11 result result VBP cord-348535-tvs1snq8 23 12 in in IN cord-348535-tvs1snq8 23 13 claims claim NNS cord-348535-tvs1snq8 23 14 , , , cord-348535-tvs1snq8 23 15 perhaps perhaps RB cord-348535-tvs1snq8 23 16 borne bear VBN cord-348535-tvs1snq8 23 17 from from IN cord-348535-tvs1snq8 23 18 hope hope NN cord-348535-tvs1snq8 23 19 and/or and/or CC cord-348535-tvs1snq8 23 20 desperation desperation NN cord-348535-tvs1snq8 23 21 , , , cord-348535-tvs1snq8 23 22 that that IN cord-348535-tvs1snq8 23 23 drugs drug NNS cord-348535-tvs1snq8 23 24 work work VBP cord-348535-tvs1snq8 23 25 , , , cord-348535-tvs1snq8 23 26 9 9 CD cord-348535-tvs1snq8 23 27 and and CC cord-348535-tvs1snq8 23 28 such such JJ cord-348535-tvs1snq8 23 29 claims claim NNS cord-348535-tvs1snq8 23 30 include include VBP cord-348535-tvs1snq8 23 31 those those DT cord-348535-tvs1snq8 23 32 from from IN cord-348535-tvs1snq8 23 33 physicians physician NNS cord-348535-tvs1snq8 23 34 stating state VBG cord-348535-tvs1snq8 23 35 very very RB cord-348535-tvs1snq8 23 36 high high JJ cord-348535-tvs1snq8 23 37 cure cure NN cord-348535-tvs1snq8 23 38 rates rate NNS cord-348535-tvs1snq8 23 39 . . . cord-348535-tvs1snq8 24 1 Clearly clearly RB cord-348535-tvs1snq8 24 2 , , , cord-348535-tvs1snq8 24 3 recruiting recruit VBG cord-348535-tvs1snq8 24 4 patients patient NNS cord-348535-tvs1snq8 24 5 recently recently RB cord-348535-tvs1snq8 24 6 diagnosed diagnose VBN cord-348535-tvs1snq8 24 7 will will MD cord-348535-tvs1snq8 24 8 have have VB cord-348535-tvs1snq8 24 9 ' ' `` cord-348535-tvs1snq8 24 10 cure cure NN cord-348535-tvs1snq8 24 11 rates rate NNS cord-348535-tvs1snq8 24 12 ' ' '' cord-348535-tvs1snq8 24 13 usually usually RB cord-348535-tvs1snq8 24 14 in in IN cord-348535-tvs1snq8 24 15 the the DT cord-348535-tvs1snq8 24 16 high high JJ cord-348535-tvs1snq8 24 17 90s% 90s% CD cord-348535-tvs1snq8 24 18 , , , cord-348535-tvs1snq8 24 19 unless unless IN cord-348535-tvs1snq8 24 20 one one CD cord-348535-tvs1snq8 24 21 focuses focus VBZ cord-348535-tvs1snq8 24 22 on on IN cord-348535-tvs1snq8 24 23 recruiting recruit VBG cord-348535-tvs1snq8 24 24 hospitalised hospitalise VBN cord-348535-tvs1snq8 24 25 patients patient NNS cord-348535-tvs1snq8 24 26 and/or and/or CC cord-348535-tvs1snq8 24 27 the the DT cord-348535-tvs1snq8 24 28 elderly elderly JJ cord-348535-tvs1snq8 24 29 , , , cord-348535-tvs1snq8 24 30 frail frail JJ cord-348535-tvs1snq8 24 31 , , , cord-348535-tvs1snq8 24 32 those those DT cord-348535-tvs1snq8 24 33 with with IN cord-348535-tvs1snq8 24 34 co co NNS cord-348535-tvs1snq8 24 35 - - NNS cord-348535-tvs1snq8 24 36 morbidities morbidity NNS cord-348535-tvs1snq8 24 37 or or CC cord-348535-tvs1snq8 24 38 a a DT cord-348535-tvs1snq8 24 39 high high JJ cord-348535-tvs1snq8 24 40 body body NN cord-348535-tvs1snq8 24 41 mass mass NN cord-348535-tvs1snq8 24 42 index index NN cord-348535-tvs1snq8 24 43 , , , cord-348535-tvs1snq8 24 44 to to TO cord-348535-tvs1snq8 24 45 name name VB cord-348535-tvs1snq8 24 46 a a DT cord-348535-tvs1snq8 24 47 few few JJ cord-348535-tvs1snq8 24 48 examples example NNS cord-348535-tvs1snq8 24 49 . . . cord-348535-tvs1snq8 25 1 A a DT cord-348535-tvs1snq8 25 2 well well RB cord-348535-tvs1snq8 25 3 - - HYPH cord-348535-tvs1snq8 25 4 known know VBN cord-348535-tvs1snq8 25 5 French french JJ cord-348535-tvs1snq8 25 6 microbiologist microbiologist NN cord-348535-tvs1snq8 25 7 on on IN cord-348535-tvs1snq8 25 8 social social JJ cord-348535-tvs1snq8 25 9 media medium NNS cord-348535-tvs1snq8 25 10 has have VBZ cord-348535-tvs1snq8 25 11 promoted promote VBN cord-348535-tvs1snq8 25 12 the the DT cord-348535-tvs1snq8 25 13 use use NN cord-348535-tvs1snq8 25 14 of of IN cord-348535-tvs1snq8 25 15 chloroquine chloroquine NN cord-348535-tvs1snq8 25 16 to to TO cord-348535-tvs1snq8 25 17 treat treat VB cord-348535-tvs1snq8 25 18 or or CC cord-348535-tvs1snq8 25 19 prevent prevent VB cord-348535-tvs1snq8 25 20 COVID-19 covid-19 CD cord-348535-tvs1snq8 25 21 . . . cord-348535-tvs1snq8 26 1 The the DT cord-348535-tvs1snq8 26 2 FDA FDA NNP cord-348535-tvs1snq8 26 3 has have VBZ cord-348535-tvs1snq8 26 4 approved approve VBN cord-348535-tvs1snq8 26 5 it -PRON- PRP cord-348535-tvs1snq8 26 6 , , , cord-348535-tvs1snq8 26 7 although although IN cord-348535-tvs1snq8 26 8 at at IN cord-348535-tvs1snq8 26 9 the the DT cord-348535-tvs1snq8 26 10 time time NN cord-348535-tvs1snq8 26 11 of of IN cord-348535-tvs1snq8 26 12 writing writing NN cord-348535-tvs1snq8 26 13 they -PRON- PRP cord-348535-tvs1snq8 26 14 have have VBP cord-348535-tvs1snq8 26 15 n't not RB cord-348535-tvs1snq8 26 16 explained explain VBN cord-348535-tvs1snq8 26 17 the the DT cord-348535-tvs1snq8 26 18 rationale rationale NN cord-348535-tvs1snq8 26 19 behind behind IN cord-348535-tvs1snq8 26 20 the the DT cord-348535-tvs1snq8 26 21 approval approval NN cord-348535-tvs1snq8 26 22 , , , cord-348535-tvs1snq8 26 23 and and CC cord-348535-tvs1snq8 26 24 as as IN cord-348535-tvs1snq8 26 25 a a DT cord-348535-tvs1snq8 26 26 consequence consequence NN cord-348535-tvs1snq8 26 27 patients patient NNS cord-348535-tvs1snq8 26 28 , , , cord-348535-tvs1snq8 26 29 institutions institution NNS cord-348535-tvs1snq8 26 30 and and CC cord-348535-tvs1snq8 26 31 the the DT cord-348535-tvs1snq8 26 32 worried worried JJ cord-348535-tvs1snq8 26 33 public public NN cord-348535-tvs1snq8 26 34 have have VBP cord-348535-tvs1snq8 26 35 demanded demand VBN cord-348535-tvs1snq8 26 36 immediate immediate JJ cord-348535-tvs1snq8 26 37 chloroquine chloroquine NN cord-348535-tvs1snq8 26 38 for for IN cord-348535-tvs1snq8 26 39 all all DT cord-348535-tvs1snq8 26 40 . . . cord-348535-tvs1snq8 27 1 The the DT cord-348535-tvs1snq8 27 2 resulting result VBG cord-348535-tvs1snq8 27 3 rush rush NN cord-348535-tvs1snq8 27 4 on on IN cord-348535-tvs1snq8 27 5 chloroquine chloroquine NN cord-348535-tvs1snq8 27 6 has have VBZ cord-348535-tvs1snq8 27 7 led lead VBN cord-348535-tvs1snq8 27 8 to to IN cord-348535-tvs1snq8 27 9 severe severe JJ cord-348535-tvs1snq8 27 10 shortages shortage NNS cord-348535-tvs1snq8 27 11 of of IN cord-348535-tvs1snq8 27 12 the the DT cord-348535-tvs1snq8 27 13 drug drug NN cord-348535-tvs1snq8 27 14 , , , cord-348535-tvs1snq8 27 15 and and CC cord-348535-tvs1snq8 27 16 patients patient NNS cord-348535-tvs1snq8 27 17 taking take VBG cord-348535-tvs1snq8 27 18 regular regular JJ cord-348535-tvs1snq8 27 19 chloroquine chloroquine NN cord-348535-tvs1snq8 27 20 or or CC cord-348535-tvs1snq8 27 21 hydroxychloroquine hydroxychloroquine NN cord-348535-tvs1snq8 27 22 for for IN cord-348535-tvs1snq8 27 23 lupus lupus NN cord-348535-tvs1snq8 27 24 or or CC cord-348535-tvs1snq8 27 25 other other JJ cord-348535-tvs1snq8 27 26 systemic systemic JJ cord-348535-tvs1snq8 27 27 diseases disease NNS cord-348535-tvs1snq8 27 28 had have VBD cord-348535-tvs1snq8 27 29 to to TO cord-348535-tvs1snq8 27 30 stop stop VB cord-348535-tvs1snq8 27 31 their -PRON- PRP$ cord-348535-tvs1snq8 27 32 treatment treatment NN cord-348535-tvs1snq8 27 33 due due IN cord-348535-tvs1snq8 27 34 to to IN cord-348535-tvs1snq8 27 35 a a DT cord-348535-tvs1snq8 27 36 lack lack NN cord-348535-tvs1snq8 27 37 of of IN cord-348535-tvs1snq8 27 38 supply supply NN cord-348535-tvs1snq8 27 39 . . . cord-348535-tvs1snq8 28 1 This this DT cord-348535-tvs1snq8 28 2 drug drug NN cord-348535-tvs1snq8 28 3 has have VBZ cord-348535-tvs1snq8 28 4 well well RB cord-348535-tvs1snq8 28 5 known know VBN cord-348535-tvs1snq8 28 6 often often RB cord-348535-tvs1snq8 28 7 serious serious JJ cord-348535-tvs1snq8 28 8 toxicities toxicity NNS cord-348535-tvs1snq8 28 9 ; ; : cord-348535-tvs1snq8 28 10 10 10 CD cord-348535-tvs1snq8 28 11 we -PRON- PRP cord-348535-tvs1snq8 28 12 note note VBP cord-348535-tvs1snq8 28 13 one one CD cord-348535-tvs1snq8 28 14 small small JJ cord-348535-tvs1snq8 28 15 study study NN cord-348535-tvs1snq8 28 16 was be VBD cord-348535-tvs1snq8 28 17 stopped stop VBN cord-348535-tvs1snq8 28 18 due due JJ cord-348535-tvs1snq8 28 19 to to IN cord-348535-tvs1snq8 28 20 potential potential JJ cord-348535-tvs1snq8 28 21 cardiac cardiac JJ cord-348535-tvs1snq8 28 22 complications complication NNS cord-348535-tvs1snq8 28 23 ( ( -LRB- cord-348535-tvs1snq8 28 24 https://www.nytimes.com/2020/04/12/health/chloroquine-coronavirus-trump.html https://www.nytimes.com/2020/04/12/health/chloroquine-coronavirus-trump.html NNP cord-348535-tvs1snq8 28 25 ) ) -RRB- cord-348535-tvs1snq8 28 26 and and CC cord-348535-tvs1snq8 28 27 we -PRON- PRP cord-348535-tvs1snq8 28 28 suggest suggest VBP cord-348535-tvs1snq8 28 29 it -PRON- PRP cord-348535-tvs1snq8 28 30 should should MD cord-348535-tvs1snq8 28 31 only only RB cord-348535-tvs1snq8 28 32 be be VB cord-348535-tvs1snq8 28 33 taken take VBN cord-348535-tvs1snq8 28 34 in in IN cord-348535-tvs1snq8 28 35 the the DT cord-348535-tvs1snq8 28 36 context context NN cord-348535-tvs1snq8 28 37 of of IN cord-348535-tvs1snq8 28 38 a a DT cord-348535-tvs1snq8 28 39 randomised randomised JJ cord-348535-tvs1snq8 28 40 or or CC cord-348535-tvs1snq8 28 41 other other JJ cord-348535-tvs1snq8 28 42 clinical clinical JJ cord-348535-tvs1snq8 28 43 study study NN cord-348535-tvs1snq8 28 44 . . . cord-348535-tvs1snq8 29 1 This this DT cord-348535-tvs1snq8 29 2 is be VBZ cord-348535-tvs1snq8 29 3 not not RB cord-348535-tvs1snq8 29 4 to to TO cord-348535-tvs1snq8 29 5 suggest suggest VB cord-348535-tvs1snq8 29 6 single single JJ cord-348535-tvs1snq8 29 7 arm arm NN cord-348535-tvs1snq8 29 8 studies study NNS cord-348535-tvs1snq8 29 9 are be VBP cord-348535-tvs1snq8 29 10 not not RB cord-348535-tvs1snq8 29 11 helpful helpful JJ cord-348535-tvs1snq8 29 12 : : : cord-348535-tvs1snq8 29 13 they -PRON- PRP cord-348535-tvs1snq8 29 14 inform inform VBP cord-348535-tvs1snq8 29 15 subsequent subsequent JJ cord-348535-tvs1snq8 29 16 trials trial NNS cord-348535-tvs1snq8 29 17 including include VBG cord-348535-tvs1snq8 29 18 dosage dosage NN cord-348535-tvs1snq8 29 19 , , , cord-348535-tvs1snq8 29 20 duration duration NN cord-348535-tvs1snq8 29 21 and and CC cord-348535-tvs1snq8 29 22 appropriate appropriate JJ cord-348535-tvs1snq8 29 23 endpoints endpoint NNS cord-348535-tvs1snq8 29 24 . . . cord-348535-tvs1snq8 30 1 For for IN cord-348535-tvs1snq8 30 2 example example NN cord-348535-tvs1snq8 30 3 , , , cord-348535-tvs1snq8 30 4 we -PRON- PRP cord-348535-tvs1snq8 30 5 have have VBP cord-348535-tvs1snq8 30 6 observed observe VBN cord-348535-tvs1snq8 30 7 11 11 CD cord-348535-tvs1snq8 30 8 that that IN cord-348535-tvs1snq8 30 9 use use NN cord-348535-tvs1snq8 30 10 of of IN cord-348535-tvs1snq8 30 11 baricitinib baricitinib NN cord-348535-tvs1snq8 30 12 for for IN cord-348535-tvs1snq8 30 13 10 10 CD cord-348535-tvs1snq8 30 14 days day NNS cord-348535-tvs1snq8 30 15 is be VBZ cord-348535-tvs1snq8 30 16 associated associate VBN cord-348535-tvs1snq8 30 17 with with IN cord-348535-tvs1snq8 30 18 viral viral JJ cord-348535-tvs1snq8 30 19 rebound rebound NN cord-348535-tvs1snq8 30 20 in in IN cord-348535-tvs1snq8 30 21 nasopharyngeal nasopharyngeal JJ cord-348535-tvs1snq8 30 22 swabs swab NNS cord-348535-tvs1snq8 30 23 in in IN cord-348535-tvs1snq8 30 24 rapidly rapidly RB cord-348535-tvs1snq8 30 25 recovered recover VBN cord-348535-tvs1snq8 30 26 and and CC cord-348535-tvs1snq8 30 27 discharged discharge VBN cord-348535-tvs1snq8 30 28 patients patient NNS cord-348535-tvs1snq8 30 29 , , , cord-348535-tvs1snq8 30 30 and and CC cord-348535-tvs1snq8 30 31 thus thus RB cord-348535-tvs1snq8 30 32 have have VBP cord-348535-tvs1snq8 30 33 recommended recommend VBN cord-348535-tvs1snq8 30 34 longer long JJR cord-348535-tvs1snq8 30 35 use use NN cord-348535-tvs1snq8 30 36 in in IN cord-348535-tvs1snq8 30 37 the the DT cord-348535-tvs1snq8 30 38 large large JJ cord-348535-tvs1snq8 30 39 randomised randomised JJ cord-348535-tvs1snq8 30 40 studies study NNS cord-348535-tvs1snq8 30 41 in in IN cord-348535-tvs1snq8 30 42 which which WDT cord-348535-tvs1snq8 30 43 it -PRON- PRP cord-348535-tvs1snq8 30 44 is be VBZ cord-348535-tvs1snq8 30 45 included include VBN cord-348535-tvs1snq8 30 46 , , , cord-348535-tvs1snq8 30 47 and and CC cord-348535-tvs1snq8 30 48 we -PRON- PRP cord-348535-tvs1snq8 30 49 suggest suggest VBP cord-348535-tvs1snq8 30 50 again again RB cord-348535-tvs1snq8 30 51 that that IN cord-348535-tvs1snq8 30 52 comparisons comparison NNS cord-348535-tvs1snq8 30 53 between between IN cord-348535-tvs1snq8 30 54 different different JJ cord-348535-tvs1snq8 30 55 therapies therapy NNS cord-348535-tvs1snq8 30 56 or or CC cord-348535-tvs1snq8 30 57 placebo placebo NN cord-348535-tvs1snq8 30 58 are be VBP cord-348535-tvs1snq8 30 59 likely likely JJ cord-348535-tvs1snq8 30 60 to to TO cord-348535-tvs1snq8 30 61 yield yield VB cord-348535-tvs1snq8 30 62 more more RBR cord-348535-tvs1snq8 30 63 informative informative JJ cord-348535-tvs1snq8 30 64 results result NNS cord-348535-tvs1snq8 30 65 than than IN cord-348535-tvs1snq8 30 66 randomised randomised JJ cord-348535-tvs1snq8 30 67 studies study NNS cord-348535-tvs1snq8 30 68 comparing compare VBG cord-348535-tvs1snq8 30 69 10 10 CD cord-348535-tvs1snq8 30 70 days day NNS cord-348535-tvs1snq8 30 71 of of IN cord-348535-tvs1snq8 30 72 intravenous intravenous JJ cord-348535-tvs1snq8 30 73 remdesevir remdesevir NNS cord-348535-tvs1snq8 30 74 with with IN cord-348535-tvs1snq8 30 75 5 5 CD cord-348535-tvs1snq8 30 76 days day NNS cord-348535-tvs1snq8 30 77 ( ( -LRB- cord-348535-tvs1snq8 30 78 https://benevolent.ai/news/potential-treatment-for-covid-19-identified-by-benevolentai-usingartificial-intelligence-enters-clinical-testing https://benevolent.ai/news/potential-treatment-for-covid-19-identified-by-benevolentai-usingartificial-intelligence-enters-clinical-testing NNP cord-348535-tvs1snq8 30 79 And and CC cord-348535-tvs1snq8 30 80 https://investor.lilly.com/news-releases/news-release-details/lilly-begins-clinical-testingtherapies-covid-19 https://investor.lilly.com/news-releases/news-release-details/lilly-begins-clinical-testingtherapies-covid-19 NNP cord-348535-tvs1snq8 30 81 ) ) -RRB- cord-348535-tvs1snq8 30 82 . . . cord-348535-tvs1snq8 31 1 With with IN cord-348535-tvs1snq8 31 2 this this DT cord-348535-tvs1snq8 31 3 in in IN cord-348535-tvs1snq8 31 4 mind mind NN cord-348535-tvs1snq8 31 5 , , , cord-348535-tvs1snq8 31 6 we -PRON- PRP cord-348535-tvs1snq8 31 7 thoroughly thoroughly RB cord-348535-tvs1snq8 31 8 congratulate congratulate VBP cord-348535-tvs1snq8 31 9 the the DT cord-348535-tvs1snq8 31 10 authors author NNS cord-348535-tvs1snq8 31 11 from from IN cord-348535-tvs1snq8 31 12 Guangzhou Guangzhou NNP cord-348535-tvs1snq8 31 13 , , , cord-348535-tvs1snq8 31 14 China China NNP cord-348535-tvs1snq8 31 15 , , , cord-348535-tvs1snq8 31 16 who who WP cord-348535-tvs1snq8 31 17 successfully successfully RB cord-348535-tvs1snq8 31 18 randomised randomise VBD cord-348535-tvs1snq8 31 19 86 86 CD cord-348535-tvs1snq8 31 20 individuals individual NNS cord-348535-tvs1snq8 31 21 with with IN cord-348535-tvs1snq8 31 22 mild mild NN cord-348535-tvs1snq8 31 23 - - HYPH cord-348535-tvs1snq8 31 24 to to IN cord-348535-tvs1snq8 31 25 - - HYPH cord-348535-tvs1snq8 31 26 moderate moderate JJ cord-348535-tvs1snq8 31 27 COVID-19 COVID-19 NNP cord-348535-tvs1snq8 31 28 in in IN cord-348535-tvs1snq8 31 29 a a DT cord-348535-tvs1snq8 31 30 2:2:1 2:2:1 CD cord-348535-tvs1snq8 31 31 design design NN cord-348535-tvs1snq8 31 32 , , , cord-348535-tvs1snq8 31 33 to to IN cord-348535-tvs1snq8 32 1 either either CC cord-348535-tvs1snq8 32 2 lopinavir lopinavir NNP cord-348535-tvs1snq8 32 3 / / SYM cord-348535-tvs1snq8 32 4 ritonavir ritonavir NNS cord-348535-tvs1snq8 32 5 , , , cord-348535-tvs1snq8 32 6 arbidol arbidol NNP cord-348535-tvs1snq8 32 7 ( ( -LRB- cord-348535-tvs1snq8 32 8 a a DT cord-348535-tvs1snq8 32 9 broad broad JJ cord-348535-tvs1snq8 32 10 spectrum spectrum JJ cord-348535-tvs1snq8 32 11 viral viral JJ cord-348535-tvs1snq8 32 12 infusion infusion NN cord-348535-tvs1snq8 32 13 inhibitor inhibitor NN cord-348535-tvs1snq8 32 14 12 12 CD cord-348535-tvs1snq8 32 15 ) ) -RRB- cord-348535-tvs1snq8 32 16 or or CC cord-348535-tvs1snq8 32 17 placebo placebo NN cord-348535-tvs1snq8 32 18 ( ( -LRB- cord-348535-tvs1snq8 32 19 NCT04252885 NCT04252885 NNP cord-348535-tvs1snq8 32 20 ) ) -RRB- cord-348535-tvs1snq8 32 21 . . . cord-348535-tvs1snq8 33 1 Because because IN cord-348535-tvs1snq8 33 2 they -PRON- PRP cord-348535-tvs1snq8 33 3 included include VBD cord-348535-tvs1snq8 33 4 only only RB cord-348535-tvs1snq8 33 5 mild mild JJ cord-348535-tvs1snq8 33 6 - - HYPH cord-348535-tvs1snq8 33 7 to to IN cord-348535-tvs1snq8 33 8 - - HYPH cord-348535-tvs1snq8 33 9 moderate moderate JJ cord-348535-tvs1snq8 33 10 patients patient NNS cord-348535-tvs1snq8 33 11 , , , cord-348535-tvs1snq8 33 12 the the DT cord-348535-tvs1snq8 33 13 pre pre JJ cord-348535-tvs1snq8 33 14 - - JJ cord-348535-tvs1snq8 33 15 defined define VBN cord-348535-tvs1snq8 33 16 primary primary JJ cord-348535-tvs1snq8 33 17 endpoint endpoint NN cord-348535-tvs1snq8 33 18 was be VBD cord-348535-tvs1snq8 33 19 the the DT cord-348535-tvs1snq8 33 20 conversion conversion NN cord-348535-tvs1snq8 33 21 at at IN cord-348535-tvs1snq8 33 22 day day NN cord-348535-tvs1snq8 33 23 21 21 CD cord-348535-tvs1snq8 33 24 of of IN cord-348535-tvs1snq8 33 25 positive positive JJ cord-348535-tvs1snq8 33 26 - - HYPH cord-348535-tvs1snq8 33 27 to to IN cord-348535-tvs1snq8 33 28 - - HYPH cord-348535-tvs1snq8 33 29 negative negative JJ cord-348535-tvs1snq8 33 30 PCR PCR NNP cord-348535-tvs1snq8 33 31 tests test NNS cord-348535-tvs1snq8 33 32 for for IN cord-348535-tvs1snq8 33 33 SARS SARS NNP cord-348535-tvs1snq8 33 34 - - HYPH cord-348535-tvs1snq8 33 35 CoV-2 CoV-2 NNP cord-348535-tvs1snq8 33 36 from from IN cord-348535-tvs1snq8 33 37 nasopharyngeal nasopharyngeal JJ cord-348535-tvs1snq8 33 38 swabs swab NNS cord-348535-tvs1snq8 33 39 . . . cord-348535-tvs1snq8 34 1 The the DT cord-348535-tvs1snq8 34 2 real real JJ cord-348535-tvs1snq8 34 3 time time NN cord-348535-tvs1snq8 34 4 reverse reverse NN cord-348535-tvs1snq8 34 5 - - HYPH cord-348535-tvs1snq8 34 6 transcriptase transcriptase NN cord-348535-tvs1snq8 34 7 PCR PCR NNP cord-348535-tvs1snq8 34 8 ( ( -LRB- cord-348535-tvs1snq8 34 9 RT RT NNP cord-348535-tvs1snq8 34 10 - - HYPH cord-348535-tvs1snq8 34 11 PCR PCR NNP cord-348535-tvs1snq8 34 12 ) ) -RRB- cord-348535-tvs1snq8 34 13 method method NN cord-348535-tvs1snq8 34 14 used use VBN cord-348535-tvs1snq8 34 15 was be VBD cord-348535-tvs1snq8 34 16 indeed indeed RB cord-348535-tvs1snq8 34 17 appropriate appropriate JJ cord-348535-tvs1snq8 34 18 as as IN cord-348535-tvs1snq8 34 19 it -PRON- PRP cord-348535-tvs1snq8 34 20 was be VBD cord-348535-tvs1snq8 34 21 performed perform VBN cord-348535-tvs1snq8 34 22 simultaneously simultaneously RB cord-348535-tvs1snq8 34 23 on on IN cord-348535-tvs1snq8 34 24 two two CD cord-348535-tvs1snq8 34 25 target target NN cord-348535-tvs1snq8 34 26 genes gene NNS cord-348535-tvs1snq8 34 27 , , , cord-348535-tvs1snq8 34 28 ORF1ab ORF1ab NNP cord-348535-tvs1snq8 34 29 and and CC cord-348535-tvs1snq8 34 30 N n CD cord-348535-tvs1snq8 34 31 genes gene NNS cord-348535-tvs1snq8 34 32 , , , cord-348535-tvs1snq8 34 33 and and CC cord-348535-tvs1snq8 34 34 positive positive JJ cord-348535-tvs1snq8 34 35 and and CC cord-348535-tvs1snq8 34 36 negative negative JJ cord-348535-tvs1snq8 34 37 controls control NNS cord-348535-tvs1snq8 34 38 were be VBD cord-348535-tvs1snq8 34 39 used use VBN cord-348535-tvs1snq8 34 40 at at IN cord-348535-tvs1snq8 34 41 each each DT cord-348535-tvs1snq8 34 42 batch batch NN cord-348535-tvs1snq8 34 43 . . . cord-348535-tvs1snq8 35 1 Negative negative JJ cord-348535-tvs1snq8 35 2 conversion conversion NN cord-348535-tvs1snq8 35 3 required require VBD cord-348535-tvs1snq8 35 4 2 2 CD cord-348535-tvs1snq8 35 5 separate separate JJ cord-348535-tvs1snq8 35 6 real real JJ cord-348535-tvs1snq8 35 7 time time NN cord-348535-tvs1snq8 35 8 RT rt NN cord-348535-tvs1snq8 35 9 - - HYPH cord-348535-tvs1snq8 35 10 PCR PCR NNP cord-348535-tvs1snq8 35 11 tests test NNS cord-348535-tvs1snq8 35 12 separated separate VBN cord-348535-tvs1snq8 35 13 by by IN cord-348535-tvs1snq8 35 14 24 24 CD cord-348535-tvs1snq8 35 15 hours hour NNS cord-348535-tvs1snq8 35 16 , , , cord-348535-tvs1snq8 35 17 and and CC cord-348535-tvs1snq8 35 18 the the DT cord-348535-tvs1snq8 35 19 entry entry NN cord-348535-tvs1snq8 35 20 criteria criterion NNS cord-348535-tvs1snq8 35 21 for for IN cord-348535-tvs1snq8 35 22 the the DT cord-348535-tvs1snq8 35 23 definition definition NN cord-348535-tvs1snq8 35 24 of of IN cord-348535-tvs1snq8 35 25 mild mild JJ cord-348535-tvs1snq8 35 26 - - HYPH cord-348535-tvs1snq8 35 27 to to IN cord-348535-tvs1snq8 35 28 - - HYPH cord-348535-tvs1snq8 35 29 moderate moderate JJ cord-348535-tvs1snq8 35 30 including include VBG cord-348535-tvs1snq8 35 31 the the DT cord-348535-tvs1snq8 35 32 absence absence NN cord-348535-tvs1snq8 35 33 of of IN cord-348535-tvs1snq8 35 34 pneumonia pneumonia NN cord-348535-tvs1snq8 35 35 are be VBP cord-348535-tvs1snq8 35 36 entirely entirely RB cord-348535-tvs1snq8 35 37 appropriate appropriate JJ cord-348535-tvs1snq8 35 38 . . . cord-348535-tvs1snq8 36 1 Baseline baseline JJ cord-348535-tvs1snq8 36 2 criteria criterion NNS cord-348535-tvs1snq8 36 3 between between IN cord-348535-tvs1snq8 36 4 the the DT cord-348535-tvs1snq8 36 5 3 3 CD cord-348535-tvs1snq8 36 6 groups group NNS cord-348535-tvs1snq8 36 7 were be VBD cord-348535-tvs1snq8 36 8 well well RB cord-348535-tvs1snq8 36 9 - - HYPH cord-348535-tvs1snq8 36 10 matched match VBN cord-348535-tvs1snq8 36 11 ( ( -LRB- cord-348535-tvs1snq8 36 12 a a DT cord-348535-tvs1snq8 36 13 criticism criticism NN cord-348535-tvs1snq8 36 14 of of IN cord-348535-tvs1snq8 36 15 one one CD cord-348535-tvs1snq8 36 16 of of IN cord-348535-tvs1snq8 36 17 the the DT cord-348535-tvs1snq8 36 18 hydroxychloroquine hydroxychloroquine NN cord-348535-tvs1snq8 36 19 randomised randomised JJ cord-348535-tvs1snq8 36 20 studies study NNS cord-348535-tvs1snq8 36 21 is be VBZ cord-348535-tvs1snq8 36 22 this this DT cord-348535-tvs1snq8 36 23 was be VBD cord-348535-tvs1snq8 36 24 not not RB cord-348535-tvs1snq8 36 25 the the DT cord-348535-tvs1snq8 36 26 case case NN cord-348535-tvs1snq8 36 27 13 13 CD cord-348535-tvs1snq8 36 28 ) ) -RRB- cord-348535-tvs1snq8 36 29 and and CC cord-348535-tvs1snq8 36 30 follow follow VB cord-348535-tvs1snq8 36 31 up up RP cord-348535-tvs1snq8 36 32 was be VBD cord-348535-tvs1snq8 36 33 appropriate appropriate JJ cord-348535-tvs1snq8 36 34 . . . cord-348535-tvs1snq8 37 1 Their -PRON- PRP$ cord-348535-tvs1snq8 37 2 data datum NNS cord-348535-tvs1snq8 37 3 helpfully helpfully RB cord-348535-tvs1snq8 37 4 shows show VBZ cord-348535-tvs1snq8 37 5 there there EX cord-348535-tvs1snq8 37 6 was be VBD cord-348535-tvs1snq8 37 7 no no DT cord-348535-tvs1snq8 37 8 difference difference NN cord-348535-tvs1snq8 37 9 between between IN cord-348535-tvs1snq8 37 10 any any DT cord-348535-tvs1snq8 37 11 of of IN cord-348535-tvs1snq8 37 12 the the DT cord-348535-tvs1snq8 37 13 groups group NNS cord-348535-tvs1snq8 37 14 in in IN cord-348535-tvs1snq8 37 15 the the DT cord-348535-tvs1snq8 37 16 primary primary JJ cord-348535-tvs1snq8 37 17 endpoint endpoint NN cord-348535-tvs1snq8 37 18 . . . cord-348535-tvs1snq8 38 1 In in IN cord-348535-tvs1snq8 38 2 the the DT cord-348535-tvs1snq8 38 3 continuing continue VBG cord-348535-tvs1snq8 38 4 search search NN cord-348535-tvs1snq8 38 5 for for IN cord-348535-tvs1snq8 38 6 safe safe JJ cord-348535-tvs1snq8 38 7 and and CC cord-348535-tvs1snq8 38 8 effective effective JJ cord-348535-tvs1snq8 38 9 new new JJ cord-348535-tvs1snq8 38 10 therapies therapy NNS cord-348535-tvs1snq8 38 11 to to TO cord-348535-tvs1snq8 38 12 treat treat VB cord-348535-tvs1snq8 38 13 patients patient NNS cord-348535-tvs1snq8 38 14 with with IN cord-348535-tvs1snq8 38 15 COVID-19 COVID-19 NNP cord-348535-tvs1snq8 38 16 , , , cord-348535-tvs1snq8 38 17 we -PRON- PRP cord-348535-tvs1snq8 38 18 require require VBP cord-348535-tvs1snq8 38 19 well well RB cord-348535-tvs1snq8 38 20 - - HYPH cord-348535-tvs1snq8 38 21 conducted conduct VBN cord-348535-tvs1snq8 38 22 ethical ethical JJ cord-348535-tvs1snq8 38 23 studies study NNS cord-348535-tvs1snq8 38 24 including include VBG cord-348535-tvs1snq8 38 25 prospective prospective JJ cord-348535-tvs1snq8 38 26 , , , cord-348535-tvs1snq8 38 27 randomised randomised JJ cord-348535-tvs1snq8 38 28 , , , cord-348535-tvs1snq8 38 29 placebocontrolled placebocontrolled JJ cord-348535-tvs1snq8 38 30 clinical clinical JJ cord-348535-tvs1snq8 38 31 studies study NNS cord-348535-tvs1snq8 38 32 such such JJ cord-348535-tvs1snq8 38 33 as as IN cord-348535-tvs1snq8 38 34 this this DT cord-348535-tvs1snq8 38 35 . . . cord-348535-tvs1snq8 39 1 Although although IN cord-348535-tvs1snq8 39 2 many many JJ cord-348535-tvs1snq8 39 3 drugs drug NNS cord-348535-tvs1snq8 39 4 have have VBP cord-348535-tvs1snq8 39 5 predicted predict VBN cord-348535-tvs1snq8 39 6 in in IN cord-348535-tvs1snq8 39 7 vitro vitro FW cord-348535-tvs1snq8 39 8 activity activity NN cord-348535-tvs1snq8 39 9 against against IN cord-348535-tvs1snq8 39 10 the the DT cord-348535-tvs1snq8 39 11 virus virus NN cord-348535-tvs1snq8 39 12 , , , cord-348535-tvs1snq8 39 13 the the DT cord-348535-tvs1snq8 39 14 proposal proposal NN cord-348535-tvs1snq8 39 15 that that IN cord-348535-tvs1snq8 39 16 such such JJ cord-348535-tvs1snq8 39 17 drugs drug NNS cord-348535-tvs1snq8 39 18 might may MD cord-348535-tvs1snq8 39 19 provide provide VB cord-348535-tvs1snq8 39 20 more more JJR cord-348535-tvs1snq8 39 21 benefit benefit NN cord-348535-tvs1snq8 39 22 than than IN cord-348535-tvs1snq8 39 23 harm harm NN cord-348535-tvs1snq8 39 24 is be VBZ cord-348535-tvs1snq8 39 25 not not RB cord-348535-tvs1snq8 39 26 appropriate appropriate JJ cord-348535-tvs1snq8 39 27 with with IN cord-348535-tvs1snq8 39 28 no no DT cord-348535-tvs1snq8 39 29 evidence evidence NN cord-348535-tvs1snq8 39 30 base base NN cord-348535-tvs1snq8 39 31 supporting support VBG cord-348535-tvs1snq8 39 32 efficacy efficacy NN cord-348535-tvs1snq8 39 33 in in IN cord-348535-tvs1snq8 39 34 any any DT cord-348535-tvs1snq8 39 35 patients patient NNS cord-348535-tvs1snq8 39 36 infected infect VBN cord-348535-tvs1snq8 39 37 with with IN cord-348535-tvs1snq8 39 38 SARS SARS NNP cord-348535-tvs1snq8 39 39 - - HYPH cord-348535-tvs1snq8 39 40 CoV-2 CoV-2 NNP cord-348535-tvs1snq8 39 41 . . . cord-348535-tvs1snq8 40 1 A a DT cord-348535-tvs1snq8 40 2 preprint preprint NN cord-348535-tvs1snq8 40 3 reporting report VBG cord-348535-tvs1snq8 40 4 results result NNS cord-348535-tvs1snq8 40 5 from from IN cord-348535-tvs1snq8 40 6 a a DT cord-348535-tvs1snq8 40 7 randomised randomised JJ cord-348535-tvs1snq8 40 8 trial trial NN cord-348535-tvs1snq8 40 9 of of IN cord-348535-tvs1snq8 40 10 the the DT cord-348535-tvs1snq8 40 11 anti anti JJ cord-348535-tvs1snq8 40 12 - - JJ cord-348535-tvs1snq8 40 13 viral viral JJ cord-348535-tvs1snq8 40 14 favipravir favipravir NNS cord-348535-tvs1snq8 40 15 versus versus IN cord-348535-tvs1snq8 40 16 arbidol arbidol NN cord-348535-tvs1snq8 40 17 in in IN cord-348535-tvs1snq8 40 18 240 240 CD cord-348535-tvs1snq8 40 19 adults adult NNS cord-348535-tvs1snq8 40 20 has have VBZ cord-348535-tvs1snq8 40 21 shown show VBN cord-348535-tvs1snq8 40 22 no no DT cord-348535-tvs1snq8 40 23 difference difference NN cord-348535-tvs1snq8 40 24 in in IN cord-348535-tvs1snq8 40 25 clinical clinical JJ cord-348535-tvs1snq8 40 26 recovery recovery NN cord-348535-tvs1snq8 40 27 at at IN cord-348535-tvs1snq8 40 28 7 7 CD cord-348535-tvs1snq8 40 29 days day NNS cord-348535-tvs1snq8 40 30 , , , cord-348535-tvs1snq8 40 31 but but CC cord-348535-tvs1snq8 40 32 cough cough NN cord-348535-tvs1snq8 40 33 and and CC cord-348535-tvs1snq8 40 34 pyrexia pyrexia NN cord-348535-tvs1snq8 40 35 were be VBD cord-348535-tvs1snq8 40 36 improved improve VBN cord-348535-tvs1snq8 40 37 on on IN cord-348535-tvs1snq8 40 38 favipravir favipravir NNS cord-348535-tvs1snq8 40 39 . . . cord-348535-tvs1snq8 41 1 14 14 CD cord-348535-tvs1snq8 42 1 These these DT cord-348535-tvs1snq8 42 2 authors author NNS cord-348535-tvs1snq8 42 3 and and CC cord-348535-tvs1snq8 42 4 Li Li NNP cord-348535-tvs1snq8 42 5 et et NNP cord-348535-tvs1snq8 42 6 al al NNP cord-348535-tvs1snq8 42 7 . . NNP cord-348535-tvs1snq8 42 8 should should MD cord-348535-tvs1snq8 42 9 be be VB cord-348535-tvs1snq8 42 10 applauded applaud VBN cord-348535-tvs1snq8 42 11 for for IN cord-348535-tvs1snq8 42 12 their -PRON- PRP$ cord-348535-tvs1snq8 42 13 efforts effort NNS cord-348535-tvs1snq8 42 14 to to TO cord-348535-tvs1snq8 42 15 add add VB cord-348535-tvs1snq8 42 16 a a DT cord-348535-tvs1snq8 42 17 useful useful JJ cord-348535-tvs1snq8 42 18 randomised randomised JJ cord-348535-tvs1snq8 42 19 trial trial NN cord-348535-tvs1snq8 42 20 to to IN cord-348535-tvs1snq8 42 21 the the DT cord-348535-tvs1snq8 42 22 literature literature NN cord-348535-tvs1snq8 42 23 , , , cord-348535-tvs1snq8 42 24 albeit albeit IN cord-348535-tvs1snq8 42 25 one one CD cord-348535-tvs1snq8 42 26 that that WDT cord-348535-tvs1snq8 42 27 is be VBZ cord-348535-tvs1snq8 42 28 negative negative JJ cord-348535-tvs1snq8 42 29 . . . cord-348535-tvs1snq8 43 1 It -PRON- PRP cord-348535-tvs1snq8 43 2 is be VBZ cord-348535-tvs1snq8 43 3 critical critical JJ cord-348535-tvs1snq8 43 4 to to TO cord-348535-tvs1snq8 43 5 publish publish VB cord-348535-tvs1snq8 43 6 such such JJ cord-348535-tvs1snq8 43 7 studies study NNS cord-348535-tvs1snq8 43 8 . . . cord-348535-tvs1snq8 44 1 International International NNP cord-348535-tvs1snq8 44 2 multicentre multicentre NNP cord-348535-tvs1snq8 44 3 trials trial NNS cord-348535-tvs1snq8 44 4 , , , cord-348535-tvs1snq8 44 5 such such JJ cord-348535-tvs1snq8 44 6 as as IN cord-348535-tvs1snq8 44 7 Discovery Discovery NNP cord-348535-tvs1snq8 44 8 ( ( -LRB- cord-348535-tvs1snq8 44 9 NCT04315948 NCT04315948 NNP cord-348535-tvs1snq8 44 10 ) ) -RRB- cord-348535-tvs1snq8 44 11 and and CC cord-348535-tvs1snq8 44 12 Solidarity Solidarity NNP cord-348535-tvs1snq8 44 13 ( ( -LRB- cord-348535-tvs1snq8 44 14 EudraCT EudraCT NNP cord-348535-tvs1snq8 44 15 Number Number NNP cord-348535-tvs1snq8 44 16 2020 2020 CD cord-348535-tvs1snq8 44 17 - - HYPH cord-348535-tvs1snq8 44 18 000982 000982 CD cord-348535-tvs1snq8 44 19 - - SYM cord-348535-tvs1snq8 44 20 18 18 CD cord-348535-tvs1snq8 44 21 ) ) -RRB- cord-348535-tvs1snq8 44 22 , , , cord-348535-tvs1snq8 44 23 will will MD cord-348535-tvs1snq8 44 24 randomise randomise VB cord-348535-tvs1snq8 44 25 patients patient NNS cord-348535-tvs1snq8 44 26 with with IN cord-348535-tvs1snq8 44 27 COVID-19 COVID-19 NNP cord-348535-tvs1snq8 44 28 to to TO cord-348535-tvs1snq8 44 29 receive receive VB cord-348535-tvs1snq8 44 30 different different JJ cord-348535-tvs1snq8 44 31 drugs drug NNS cord-348535-tvs1snq8 44 32 in in IN cord-348535-tvs1snq8 44 33 adaptive adaptive JJ cord-348535-tvs1snq8 44 34 study study NN cord-348535-tvs1snq8 44 35 designs design NNS cord-348535-tvs1snq8 44 36 . . . cord-348535-tvs1snq8 45 1 Such such JJ cord-348535-tvs1snq8 45 2 initiatives initiative NNS cord-348535-tvs1snq8 45 3 will will MD cord-348535-tvs1snq8 45 4 provide provide VB cord-348535-tvs1snq8 45 5 the the DT cord-348535-tvs1snq8 45 6 best good JJS cord-348535-tvs1snq8 45 7 and and CC cord-348535-tvs1snq8 45 8 most most RBS cord-348535-tvs1snq8 45 9 relevant relevant JJ cord-348535-tvs1snq8 45 10 data datum NNS cord-348535-tvs1snq8 45 11 to to TO cord-348535-tvs1snq8 45 12 guide guide VB cord-348535-tvs1snq8 45 13 management management NN cord-348535-tvs1snq8 45 14 of of IN cord-348535-tvs1snq8 45 15 patients patient NNS cord-348535-tvs1snq8 45 16 with with IN cord-348535-tvs1snq8 45 17 COVID-19 COVID-19 NNP cord-348535-tvs1snq8 45 18 . . . cord-348535-tvs1snq8 46 1 Whether whether IN cord-348535-tvs1snq8 46 2 antiviral antiviral JJ cord-348535-tvs1snq8 46 3 , , , cord-348535-tvs1snq8 46 4 immunomodulatory immunomodulatory JJ cord-348535-tvs1snq8 46 5 or or CC cord-348535-tvs1snq8 46 6 antimalarial antimalarial JJ cord-348535-tvs1snq8 46 7 drugs drug NNS cord-348535-tvs1snq8 46 8 could could MD cord-348535-tvs1snq8 46 9 be be VB cord-348535-tvs1snq8 46 10 effective effective JJ cord-348535-tvs1snq8 46 11 in in IN cord-348535-tvs1snq8 46 12 changing change VBG cord-348535-tvs1snq8 46 13 the the DT cord-348535-tvs1snq8 46 14 disease disease NN cord-348535-tvs1snq8 46 15 course course NN cord-348535-tvs1snq8 46 16 in in IN cord-348535-tvs1snq8 46 17 patients patient NNS cord-348535-tvs1snq8 46 18 with with IN cord-348535-tvs1snq8 46 19 either either CC cord-348535-tvs1snq8 46 20 mild mild JJ cord-348535-tvs1snq8 46 21 or or CC cord-348535-tvs1snq8 46 22 severe severe JJ cord-348535-tvs1snq8 46 23 COVID-19 covid-19 NN cord-348535-tvs1snq8 46 24 remains remain VBZ cord-348535-tvs1snq8 46 25 unknown unknown JJ cord-348535-tvs1snq8 46 26 . . . cord-348535-tvs1snq8 47 1 When when WRB cord-348535-tvs1snq8 47 2 patients patient NNS cord-348535-tvs1snq8 47 3 take take VBP cord-348535-tvs1snq8 47 4 these these DT cord-348535-tvs1snq8 47 5 off off IN cord-348535-tvs1snq8 47 6 - - HYPH cord-348535-tvs1snq8 47 7 label label NN cord-348535-tvs1snq8 47 8 and and CC cord-348535-tvs1snq8 47 9 recover recover VB cord-348535-tvs1snq8 47 10 it -PRON- PRP cord-348535-tvs1snq8 47 11 is be VBZ cord-348535-tvs1snq8 47 12 not not RB cord-348535-tvs1snq8 47 13 known know VBN cord-348535-tvs1snq8 47 14 whether whether IN cord-348535-tvs1snq8 47 15 the the DT cord-348535-tvs1snq8 47 16 drug drug NN cord-348535-tvs1snq8 47 17 was be VBD cord-348535-tvs1snq8 47 18 helpful helpful JJ cord-348535-tvs1snq8 47 19 in in IN cord-348535-tvs1snq8 47 20 the the DT cord-348535-tvs1snq8 47 21 disease disease NN cord-348535-tvs1snq8 47 22 course course NN cord-348535-tvs1snq8 47 23 without without IN cord-348535-tvs1snq8 47 24 randomisation randomisation NN cord-348535-tvs1snq8 47 25 . . . cord-348535-tvs1snq8 48 1 Similarly similarly RB cord-348535-tvs1snq8 48 2 , , , cord-348535-tvs1snq8 48 3 when when WRB cord-348535-tvs1snq8 48 4 patients patient NNS cord-348535-tvs1snq8 48 5 deteriorate deteriorate VBP cord-348535-tvs1snq8 48 6 , , , cord-348535-tvs1snq8 48 7 we -PRON- PRP cord-348535-tvs1snq8 48 8 do do VBP cord-348535-tvs1snq8 48 9 not not RB cord-348535-tvs1snq8 48 10 know know VB cord-348535-tvs1snq8 48 11 if if IN cord-348535-tvs1snq8 48 12 they -PRON- PRP cord-348535-tvs1snq8 48 13 should should MD cord-348535-tvs1snq8 48 14 be be VB cord-348535-tvs1snq8 48 15 continued continue VBN cord-348535-tvs1snq8 48 16 or or CC cord-348535-tvs1snq8 48 17 considered consider VBN cord-348535-tvs1snq8 48 18 clinically clinically RB cord-348535-tvs1snq8 48 19 ineffective ineffective JJ cord-348535-tvs1snq8 48 20 and and CC cord-348535-tvs1snq8 48 21 stopped stop VBD cord-348535-tvs1snq8 48 22 . . . cord-348535-tvs1snq8 49 1 Assessing assess VBG cord-348535-tvs1snq8 49 2 viral viral JJ cord-348535-tvs1snq8 49 3 loads load NNS cord-348535-tvs1snq8 49 4 by by IN cord-348535-tvs1snq8 49 5 PCR PCR NNP cord-348535-tvs1snq8 49 6 on on IN cord-348535-tvs1snq8 49 7 nasopharyngeal nasopharyngeal JJ cord-348535-tvs1snq8 49 8 swabs swab NNS cord-348535-tvs1snq8 49 9 as as IN cord-348535-tvs1snq8 49 10 performed perform VBN cord-348535-tvs1snq8 49 11 in in IN cord-348535-tvs1snq8 49 12 the the DT cord-348535-tvs1snq8 49 13 trial trial NN cord-348535-tvs1snq8 49 14 here here RB cord-348535-tvs1snq8 49 15 , , , cord-348535-tvs1snq8 49 16 will will MD cord-348535-tvs1snq8 49 17 help help VB cord-348535-tvs1snq8 49 18 clarify clarify VB cord-348535-tvs1snq8 49 19 the the DT cord-348535-tvs1snq8 49 20 roles role NNS cord-348535-tvs1snq8 49 21 of of IN cord-348535-tvs1snq8 49 22 these these DT cord-348535-tvs1snq8 49 23 medicines medicine NNS cord-348535-tvs1snq8 49 24 going go VBG cord-348535-tvs1snq8 49 25 forwards forwards RB cord-348535-tvs1snq8 49 26 . . . cord-348535-tvs1snq8 50 1 COVID-19 covid-19 LS cord-348535-tvs1snq8 50 2 : : : cord-348535-tvs1snq8 50 3 extending extend VBG cord-348535-tvs1snq8 50 4 or or CC cord-348535-tvs1snq8 50 5 relaxing relax VBG cord-348535-tvs1snq8 50 6 distancing distance VBG cord-348535-tvs1snq8 50 7 control control NN cord-348535-tvs1snq8 50 8 measures measure NNS cord-348535-tvs1snq8 50 9 Impact Impact NNP cord-348535-tvs1snq8 50 10 assessment assessment NN cord-348535-tvs1snq8 50 11 of of IN cord-348535-tvs1snq8 50 12 non non JJ cord-348535-tvs1snq8 50 13 - - JJ cord-348535-tvs1snq8 50 14 pharmaceutical pharmaceutical JJ cord-348535-tvs1snq8 50 15 interventions intervention NNS cord-348535-tvs1snq8 50 16 against against IN cord-348535-tvs1snq8 50 17 coronavirus coronavirus NN cord-348535-tvs1snq8 50 18 disease disease NN cord-348535-tvs1snq8 50 19 2019 2019 CD cord-348535-tvs1snq8 50 20 and and CC cord-348535-tvs1snq8 50 21 influenza influenza NN cord-348535-tvs1snq8 50 22 in in IN cord-348535-tvs1snq8 50 23 Hong Hong NNP cord-348535-tvs1snq8 50 24 Kong Kong NNP cord-348535-tvs1snq8 51 1 : : : cord-348535-tvs1snq8 51 2 an an DT cord-348535-tvs1snq8 51 3 observational observational JJ cord-348535-tvs1snq8 51 4 study study NN cord-348535-tvs1snq8 52 1 The the DT cord-348535-tvs1snq8 52 2 effect effect NN cord-348535-tvs1snq8 52 3 of of IN cord-348535-tvs1snq8 52 4 control control NN cord-348535-tvs1snq8 52 5 strategies strategy NNS cord-348535-tvs1snq8 52 6 to to TO cord-348535-tvs1snq8 52 7 reduce reduce VB cord-348535-tvs1snq8 52 8 social social JJ cord-348535-tvs1snq8 52 9 mixing mixing NN cord-348535-tvs1snq8 52 10 on on IN cord-348535-tvs1snq8 52 11 outcomes outcome NNS cord-348535-tvs1snq8 52 12 of of IN cord-348535-tvs1snq8 52 13 the the DT cord-348535-tvs1snq8 52 14 COVID-19 covid-19 JJ cord-348535-tvs1snq8 52 15 epidemic epidemic NN cord-348535-tvs1snq8 52 16 in in IN cord-348535-tvs1snq8 52 17 Wuhan Wuhan NNP cord-348535-tvs1snq8 52 18 , , , cord-348535-tvs1snq8 52 19 China China NNP cord-348535-tvs1snq8 52 20 : : : cord-348535-tvs1snq8 52 21 a a DT cord-348535-tvs1snq8 52 22 modelling modelling NN cord-348535-tvs1snq8 52 23 study study NN cord-348535-tvs1snq8 52 24 Baricitinib Baricitinib NNP cord-348535-tvs1snq8 52 25 as as IN cord-348535-tvs1snq8 52 26 potential potential JJ cord-348535-tvs1snq8 52 27 treatment treatment NN cord-348535-tvs1snq8 52 28 for for IN cord-348535-tvs1snq8 52 29 2019-nCoV 2019-ncov CD cord-348535-tvs1snq8 52 30 acute acute JJ cord-348535-tvs1snq8 52 31 respiratory respiratory JJ cord-348535-tvs1snq8 52 32 disease disease NN cord-348535-tvs1snq8 52 33 COVID-19 covid-19 NN cord-348535-tvs1snq8 52 34 : : : cord-348535-tvs1snq8 52 35 combining combine VBG cord-348535-tvs1snq8 52 36 antiviral antiviral JJ cord-348535-tvs1snq8 52 37 and and CC cord-348535-tvs1snq8 52 38 anti anti JJ cord-348535-tvs1snq8 52 39 - - JJ cord-348535-tvs1snq8 52 40 inflammatory inflammatory JJ cord-348535-tvs1snq8 52 41 treatments treatment NNS cord-348535-tvs1snq8 53 1 A a DT cord-348535-tvs1snq8 53 2 Trial Trial NNP cord-348535-tvs1snq8 53 3 of of IN cord-348535-tvs1snq8 53 4 Lopinavir Lopinavir NNP cord-348535-tvs1snq8 53 5 - - HYPH cord-348535-tvs1snq8 53 6 Ritonavir Ritonavir NNP cord-348535-tvs1snq8 53 7 in in IN cord-348535-tvs1snq8 53 8 Adults Adults NNPS cord-348535-tvs1snq8 53 9 Hospitalized hospitalize VBN cord-348535-tvs1snq8 53 10 with with IN cord-348535-tvs1snq8 53 11 Severe severe JJ cord-348535-tvs1snq8 53 12 Covid-19 covid-19 NN cord-348535-tvs1snq8 53 13 Compassionate compassionate JJ cord-348535-tvs1snq8 53 14 Use Use NNP cord-348535-tvs1snq8 53 15 of of IN cord-348535-tvs1snq8 53 16 Remdesivir Remdesivir NNP cord-348535-tvs1snq8 53 17 for for IN cord-348535-tvs1snq8 53 18 Patients patient NNS cord-348535-tvs1snq8 53 19 with with IN cord-348535-tvs1snq8 53 20 Severe severe JJ cord-348535-tvs1snq8 53 21 Covid-19 Covid-19 NNP cord-348535-tvs1snq8 53 22 Clinical clinical JJ cord-348535-tvs1snq8 53 23 and and CC cord-348535-tvs1snq8 53 24 virological virological JJ cord-348535-tvs1snq8 53 25 data datum NNS cord-348535-tvs1snq8 53 26 of of IN cord-348535-tvs1snq8 53 27 the the DT cord-348535-tvs1snq8 53 28 first first JJ cord-348535-tvs1snq8 53 29 cases case NNS cord-348535-tvs1snq8 53 30 of of IN cord-348535-tvs1snq8 53 31 COVID-19 covid-19 CD cord-348535-tvs1snq8 53 32 in in IN cord-348535-tvs1snq8 53 33 Europe Europe NNP cord-348535-tvs1snq8 53 34 : : : cord-348535-tvs1snq8 54 1 a a DT cord-348535-tvs1snq8 54 2 case case NN cord-348535-tvs1snq8 54 3 series series NN cord-348535-tvs1snq8 54 4 Chloroquine Chloroquine NNP cord-348535-tvs1snq8 54 5 for for IN cord-348535-tvs1snq8 54 6 COVID-19 COVID-19 NNP cord-348535-tvs1snq8 54 7 Infection Infection NNP cord-348535-tvs1snq8 54 8 Mechanism Mechanism NNP cord-348535-tvs1snq8 54 9 of of IN cord-348535-tvs1snq8 54 10 baricitinib baricitinib NNP cord-348535-tvs1snq8 54 11 supports support VBZ cord-348535-tvs1snq8 54 12 artificial artificial JJ cord-348535-tvs1snq8 54 13 intelligence intelligence NN cord-348535-tvs1snq8 54 14 - - HYPH cord-348535-tvs1snq8 54 15 predicted predict VBN cord-348535-tvs1snq8 54 16 testing testing NN cord-348535-tvs1snq8 54 17 in in IN cord-348535-tvs1snq8 54 18 COVID-19 COVID-19 NNP cord-348535-tvs1snq8 54 19 patients patient NNS cord-348535-tvs1snq8 54 20 Arbidol Arbidol NNP cord-348535-tvs1snq8 54 21 : : : cord-348535-tvs1snq8 54 22 a a DT cord-348535-tvs1snq8 54 23 broad broad JJ cord-348535-tvs1snq8 54 24 - - HYPH cord-348535-tvs1snq8 54 25 spectrum spectrum NN cord-348535-tvs1snq8 54 26 antiviral antiviral JJ cord-348535-tvs1snq8 54 27 compound compound NN cord-348535-tvs1snq8 54 28 that that WDT cord-348535-tvs1snq8 54 29 blocks block VBZ cord-348535-tvs1snq8 54 30 viral viral JJ cord-348535-tvs1snq8 54 31 fusion fusion NN cord-348535-tvs1snq8 54 32 Hydroxychloroquine Hydroxychloroquine NNP cord-348535-tvs1snq8 54 33 in in IN cord-348535-tvs1snq8 54 34 the the DT cord-348535-tvs1snq8 54 35 management management NN cord-348535-tvs1snq8 54 36 of of IN cord-348535-tvs1snq8 54 37 critically critically RB cord-348535-tvs1snq8 54 38 ill ill JJ cord-348535-tvs1snq8 54 39 patients patient NNS cord-348535-tvs1snq8 54 40 with with IN cord-348535-tvs1snq8 54 41 COVID-19 covid-19 VB cord-348535-tvs1snq8 54 42 : : : cord-348535-tvs1snq8 54 43 the the DT cord-348535-tvs1snq8 54 44 need need NN cord-348535-tvs1snq8 54 45 for for IN cord-348535-tvs1snq8 54 46 an an DT cord-348535-tvs1snq8 54 47 evidence evidence NN cord-348535-tvs1snq8 54 48 base base NN cord-348535-tvs1snq8 54 49 Favipiravir Favipiravir NNP cord-348535-tvs1snq8 54 50 versus versus IN cord-348535-tvs1snq8 54 51 Arbidol Arbidol NNP cord-348535-tvs1snq8 54 52 for for IN cord-348535-tvs1snq8 54 53 COVID-19 COVID-19 NNP cord-348535-tvs1snq8 54 54 : : : cord-348535-tvs1snq8 54 55 A a DT cord-348535-tvs1snq8 54 56 Randomized Randomized NNP cord-348535-tvs1snq8 54 57 Clinical Clinical NNP cord-348535-tvs1snq8 54 58 Trial Trial NNP cord-348535-tvs1snq8 54 59 . . . cord-348535-tvs1snq8 55 1 medRxiv medRxiv NNP cord-348535-tvs1snq8 55 2 S.O. S.O. NNP cord-348535-tvs1snq8 55 3 and and CC cord-348535-tvs1snq8 55 4 J.S. J.S. NNP cord-348535-tvs1snq8 55 5 wrote write VBD cord-348535-tvs1snq8 55 6 the the DT cord-348535-tvs1snq8 55 7 manuscript manuscript NN cord-348535-tvs1snq8 55 8 and and CC cord-348535-tvs1snq8 55 9 approved approve VBD cord-348535-tvs1snq8 55 10 the the DT cord-348535-tvs1snq8 55 11 final final JJ cord-348535-tvs1snq8 55 12 version version NN cord-348535-tvs1snq8 55 13 . . . cord-348535-tvs1snq8 56 1 None none NN cord-348535-tvs1snq8 56 2 . . . cord-348535-tvs1snq8 57 1 J.S. J.S. NNP cord-348535-tvs1snq8 57 2 conflicts conflict NNS cord-348535-tvs1snq8 57 3 can can MD cord-348535-tvs1snq8 57 4 be be VB cord-348535-tvs1snq8 57 5 found find VBN cord-348535-tvs1snq8 57 6 at at IN cord-348535-tvs1snq8 57 7 https://www.nature.com/onc/editors https://www.nature.com/onc/editor NNS cord-348535-tvs1snq8 57 8 but but CC cord-348535-tvs1snq8 57 9 none none NN cord-348535-tvs1snq8 57 10 are be VBP cord-348535-tvs1snq8 57 11 relevant relevant JJ cord-348535-tvs1snq8 57 12 to to IN cord-348535-tvs1snq8 57 13 this this DT cord-348535-tvs1snq8 57 14 piece piece NN cord-348535-tvs1snq8 57 15 . . . cord-348535-tvs1snq8 58 1 S.O. S.O. NNP cord-348535-tvs1snq8 58 2 reports report VBZ cord-348535-tvs1snq8 58 3 no no DT cord-348535-tvs1snq8 58 4 conflicts conflict NNS cord-348535-tvs1snq8 58 5 . . .