id sid tid token lemma pos cord-346917-5dgnj11a 1 1 key key NN cord-346917-5dgnj11a 1 2 : : : cord-346917-5dgnj11a 2 1 cord-346917 cord-346917 NNS cord-346917-5dgnj11a 2 2 - - HYPH cord-346917-5dgnj11a 2 3 5dgnj11a 5dgnj11a CD cord-346917-5dgnj11a 2 4 authors author NNS cord-346917-5dgnj11a 2 5 : : : cord-346917-5dgnj11a 2 6 Kuppalli Kuppalli NNP cord-346917-5dgnj11a 2 7 , , , cord-346917-5dgnj11a 2 8 Krutika Krutika NNP cord-346917-5dgnj11a 2 9 ; ; : cord-346917-5dgnj11a 2 10 Rasmussen Rasmussen NNP cord-346917-5dgnj11a 2 11 , , , cord-346917-5dgnj11a 2 12 Angela Angela NNP cord-346917-5dgnj11a 2 13 L. L. NNP cord-346917-5dgnj11a 2 14 title title NN cord-346917-5dgnj11a 2 15 : : : cord-346917-5dgnj11a 3 1 A a DT cord-346917-5dgnj11a 3 2 glimpse glimpse NN cord-346917-5dgnj11a 3 3 into into IN cord-346917-5dgnj11a 3 4 the the DT cord-346917-5dgnj11a 3 5 eye eye NN cord-346917-5dgnj11a 3 6 of of IN cord-346917-5dgnj11a 3 7 the the DT cord-346917-5dgnj11a 3 8 COVID-19 covid-19 JJ cord-346917-5dgnj11a 3 9 cytokine cytokine NN cord-346917-5dgnj11a 3 10 storm storm NN cord-346917-5dgnj11a 3 11 date date NN cord-346917-5dgnj11a 3 12 : : : cord-346917-5dgnj11a 3 13 2020 2020 CD cord-346917-5dgnj11a 3 14 - - HYPH cord-346917-5dgnj11a 3 15 05 05 CD cord-346917-5dgnj11a 3 16 - - HYPH cord-346917-5dgnj11a 3 17 07 07 CD cord-346917-5dgnj11a 3 18 journal journal NN cord-346917-5dgnj11a 3 19 : : : cord-346917-5dgnj11a 4 1 EBioMedicine ebiomedicine NN cord-346917-5dgnj11a 4 2 DOI DOI NNP cord-346917-5dgnj11a 4 3 : : : cord-346917-5dgnj11a 4 4 10.1016 10.1016 CD cord-346917-5dgnj11a 4 5 / / SYM cord-346917-5dgnj11a 4 6 j.ebiom.2020.102789 j.ebiom.2020.102789 NNP cord-346917-5dgnj11a 4 7 sha sha NNP cord-346917-5dgnj11a 4 8 : : : cord-346917-5dgnj11a 4 9 16886f5c52cc823bf1c2a6139075959aabd1134c 16886f5c52cc823bf1c2a6139075959aabd1134c CD cord-346917-5dgnj11a 4 10 doc_id doc_id CD cord-346917-5dgnj11a 4 11 : : : cord-346917-5dgnj11a 4 12 346917 346917 CD cord-346917-5dgnj11a 4 13 cord_uid cord_uid NNS cord-346917-5dgnj11a 4 14 : : : cord-346917-5dgnj11a 5 1 5dgnj11a 5dgnj11a LS cord-346917-5dgnj11a 5 2 nan nan NNP cord-346917-5dgnj11a 6 1 The the DT cord-346917-5dgnj11a 6 2 pathogenesis pathogenesis NN cord-346917-5dgnj11a 6 3 of of IN cord-346917-5dgnj11a 6 4 pandemic pandemic NN cord-346917-5dgnj11a 6 5 coronavirus coronavirus NN cord-346917-5dgnj11a 6 6 disease-2019 disease-2019 NNP cord-346917-5dgnj11a 6 7 ( ( -LRB- cord-346917-5dgnj11a 6 8 COVID-19 COVID-19 NNP cord-346917-5dgnj11a 6 9 ) ) -RRB- cord-346917-5dgnj11a 6 10 caused cause VBN cord-346917-5dgnj11a 6 11 by by IN cord-346917-5dgnj11a 6 12 severe severe JJ cord-346917-5dgnj11a 6 13 acute acute JJ cord-346917-5dgnj11a 6 14 respiratory respiratory JJ cord-346917-5dgnj11a 6 15 syndrome syndrome NN cord-346917-5dgnj11a 6 16 coronavirus coronavirus NN cord-346917-5dgnj11a 6 17 2 2 CD cord-346917-5dgnj11a 7 1 ( ( -LRB- cord-346917-5dgnj11a 7 2 SARS SARS NNP cord-346917-5dgnj11a 7 3 - - HYPH cord-346917-5dgnj11a 7 4 CoV-2 CoV-2 NNP cord-346917-5dgnj11a 7 5 ) ) -RRB- cord-346917-5dgnj11a 7 6 likely likely RB cord-346917-5dgnj11a 7 7 depends depend VBZ cord-346917-5dgnj11a 7 8 heavily heavily RB cord-346917-5dgnj11a 7 9 on on IN cord-346917-5dgnj11a 7 10 disruption disruption NN cord-346917-5dgnj11a 7 11 of of IN cord-346917-5dgnj11a 7 12 immune immune JJ cord-346917-5dgnj11a 7 13 and and CC cord-346917-5dgnj11a 7 14 inflammatory inflammatory JJ cord-346917-5dgnj11a 7 15 processes process NNS cord-346917-5dgnj11a 7 16 . . . cord-346917-5dgnj11a 8 1 Thus thus RB cord-346917-5dgnj11a 8 2 far far RB cord-346917-5dgnj11a 8 3 , , , cord-346917-5dgnj11a 8 4 the the DT cord-346917-5dgnj11a 8 5 precise precise JJ cord-346917-5dgnj11a 8 6 immune immune JJ cord-346917-5dgnj11a 8 7 mechanisms mechanism NNS cord-346917-5dgnj11a 8 8 have have VBP cord-346917-5dgnj11a 8 9 not not RB cord-346917-5dgnj11a 8 10 been be VBN cord-346917-5dgnj11a 8 11 fully fully RB cord-346917-5dgnj11a 8 12 elucidated elucidate VBN cord-346917-5dgnj11a 8 13 or or CC cord-346917-5dgnj11a 8 14 studied study VBN cord-346917-5dgnj11a 8 15 in in IN cord-346917-5dgnj11a 8 16 detail detail NN cord-346917-5dgnj11a 8 17 . . . cord-346917-5dgnj11a 9 1 In in IN cord-346917-5dgnj11a 9 2 this this DT cord-346917-5dgnj11a 9 3 issue issue NN cord-346917-5dgnj11a 9 4 of of IN cord-346917-5dgnj11a 9 5 EBioMedicine EBioMedicine NNP cord-346917-5dgnj11a 9 6 , , , cord-346917-5dgnj11a 9 7 Liu Liu NNP cord-346917-5dgnj11a 9 8 and and CC cord-346917-5dgnj11a 9 9 colleagues colleague NNS cord-346917-5dgnj11a 9 10 [ [ -LRB- cord-346917-5dgnj11a 9 11 1 1 CD cord-346917-5dgnj11a 9 12 ] ] -RRB- cord-346917-5dgnj11a 9 13 showed show VBD cord-346917-5dgnj11a 9 14 that that IN cord-346917-5dgnj11a 9 15 patients patient NNS cord-346917-5dgnj11a 9 16 with with IN cord-346917-5dgnj11a 9 17 severe severe JJ cord-346917-5dgnj11a 9 18 COVID-19 COVID-19 NNP cord-346917-5dgnj11a 9 19 had have VBD cord-346917-5dgnj11a 9 20 lymphopenia lymphopenia VBN cord-346917-5dgnj11a 9 21 and and CC cord-346917-5dgnj11a 9 22 increased increase VBN cord-346917-5dgnj11a 9 23 neutrophil neutrophil NN cord-346917-5dgnj11a 9 24 counts count NNS cord-346917-5dgnj11a 9 25 along along IN cord-346917-5dgnj11a 9 26 with with IN cord-346917-5dgnj11a 9 27 high high JJ cord-346917-5dgnj11a 9 28 levels level NNS cord-346917-5dgnj11a 9 29 of of IN cord-346917-5dgnj11a 9 30 circulating circulate VBG cord-346917-5dgnj11a 9 31 pro pro JJ cord-346917-5dgnj11a 9 32 - - JJ cord-346917-5dgnj11a 9 33 inflammatory inflammatory JJ cord-346917-5dgnj11a 9 34 cytokines cytokine NNS cord-346917-5dgnj11a 9 35 compared compare VBN cord-346917-5dgnj11a 9 36 to to IN cord-346917-5dgnj11a 9 37 patients patient NNS cord-346917-5dgnj11a 9 38 with with IN cord-346917-5dgnj11a 9 39 mild mild JJ cord-346917-5dgnj11a 9 40 COVID-19 covid-19 JJ cord-346917-5dgnj11a 9 41 illness illness NN cord-346917-5dgnj11a 9 42 . . . cord-346917-5dgnj11a 10 1 The the DT cord-346917-5dgnj11a 10 2 investigators investigator NNS cord-346917-5dgnj11a 10 3 used use VBD cord-346917-5dgnj11a 10 4 flow flow NN cord-346917-5dgnj11a 10 5 cytometry cytometry NN cord-346917-5dgnj11a 10 6 to to TO cord-346917-5dgnj11a 10 7 investigate investigate VB cord-346917-5dgnj11a 10 8 immune immune JJ cord-346917-5dgnj11a 10 9 phenotype phenotype NN cord-346917-5dgnj11a 10 10 and and CC cord-346917-5dgnj11a 10 11 function function NN cord-346917-5dgnj11a 10 12 of of IN cord-346917-5dgnj11a 10 13 peripheral peripheral JJ cord-346917-5dgnj11a 10 14 blood blood NN cord-346917-5dgnj11a 10 15 mononuclear mononuclear NN cord-346917-5dgnj11a 10 16 cells cell NNS cord-346917-5dgnj11a 10 17 ( ( -LRB- cord-346917-5dgnj11a 10 18 PBMC PBMC NNP cord-346917-5dgnj11a 10 19 ) ) -RRB- cord-346917-5dgnj11a 10 20 , , , cord-346917-5dgnj11a 10 21 as as RB cord-346917-5dgnj11a 10 22 well well RB cord-346917-5dgnj11a 10 23 as as IN cord-346917-5dgnj11a 10 24 quantified quantify VBN cord-346917-5dgnj11a 10 25 plasma plasma NN cord-346917-5dgnj11a 10 26 cytokine cytokine NN cord-346917-5dgnj11a 10 27 levels level NNS cord-346917-5dgnj11a 10 28 , , , cord-346917-5dgnj11a 10 29 from from IN cord-346917-5dgnj11a 10 30 40 40 CD cord-346917-5dgnj11a 10 31 COVID-19 covid-19 CD cord-346917-5dgnj11a 10 32 patients patient NNS cord-346917-5dgnj11a 10 33 . . . cord-346917-5dgnj11a 11 1 In in IN cord-346917-5dgnj11a 11 2 particular particular JJ cord-346917-5dgnj11a 11 3 , , , cord-346917-5dgnj11a 11 4 substantial substantial JJ cord-346917-5dgnj11a 11 5 depletion depletion NN cord-346917-5dgnj11a 11 6 of of IN cord-346917-5dgnj11a 11 7 CD8 CD8 NNP cord-346917-5dgnj11a 11 8 + + CC cord-346917-5dgnj11a 11 9 T T NNP cord-346917-5dgnj11a 11 10 cells cell NNS cord-346917-5dgnj11a 11 11 were be VBD cord-346917-5dgnj11a 11 12 associated associate VBN cord-346917-5dgnj11a 11 13 with with IN cord-346917-5dgnj11a 11 14 disease disease NN cord-346917-5dgnj11a 11 15 severity severity NN cord-346917-5dgnj11a 11 16 , , , cord-346917-5dgnj11a 11 17 and and CC cord-346917-5dgnj11a 11 18 both both CC cord-346917-5dgnj11a 11 19 the the DT cord-346917-5dgnj11a 11 20 ratios ratio NNS cord-346917-5dgnj11a 11 21 of of IN cord-346917-5dgnj11a 11 22 neutrophils neutrophil NNS cord-346917-5dgnj11a 11 23 to to IN cord-346917-5dgnj11a 11 24 CD8 CD8 NNP cord-346917-5dgnj11a 11 25 + + CC cord-346917-5dgnj11a 11 26 T T NNP cord-346917-5dgnj11a 11 27 cells cell NNS cord-346917-5dgnj11a 11 28 ( ( -LRB- cord-346917-5dgnj11a 11 29 N8R n8r CD cord-346917-5dgnj11a 11 30 ) ) -RRB- cord-346917-5dgnj11a 11 31 and and CC cord-346917-5dgnj11a 11 32 neutrophils neutrophil NNS cord-346917-5dgnj11a 11 33 to to IN cord-346917-5dgnj11a 11 34 lymphocytes lymphocyte NNS cord-346917-5dgnj11a 11 35 ( ( -LRB- cord-346917-5dgnj11a 11 36 NLR NLR NNP cord-346917-5dgnj11a 11 37 ) ) -RRB- cord-346917-5dgnj11a 11 38 were be VBD cord-346917-5dgnj11a 11 39 predictive predictive JJ cord-346917-5dgnj11a 11 40 of of IN cord-346917-5dgnj11a 11 41 COVID-19 covid-19 JJ cord-346917-5dgnj11a 11 42 outcome outcome NN cord-346917-5dgnj11a 11 43 . . . cord-346917-5dgnj11a 12 1 These these DT cord-346917-5dgnj11a 12 2 data datum NNS cord-346917-5dgnj11a 12 3 suggest suggest VBP cord-346917-5dgnj11a 12 4 that that IN cord-346917-5dgnj11a 12 5 depletion depletion NN cord-346917-5dgnj11a 12 6 of of IN cord-346917-5dgnj11a 12 7 lymphocytes lymphocyte NNS cord-346917-5dgnj11a 12 8 , , , cord-346917-5dgnj11a 12 9 particularly particularly RB cord-346917-5dgnj11a 12 10 cytotoxic cytotoxic JJ cord-346917-5dgnj11a 12 11 T t NN cord-346917-5dgnj11a 12 12 lymphocytes lymphocyte NNS cord-346917-5dgnj11a 12 13 that that WDT cord-346917-5dgnj11a 12 14 function function VBP cord-346917-5dgnj11a 12 15 by by IN cord-346917-5dgnj11a 12 16 eliminating eliminate VBG cord-346917-5dgnj11a 12 17 infected infected JJ cord-346917-5dgnj11a 12 18 cells cell NNS cord-346917-5dgnj11a 12 19 , , , cord-346917-5dgnj11a 12 20 coupled couple VBN cord-346917-5dgnj11a 12 21 with with IN cord-346917-5dgnj11a 12 22 neutrophils neutrophil NNS cord-346917-5dgnj11a 12 23 capable capable JJ cord-346917-5dgnj11a 12 24 of of IN cord-346917-5dgnj11a 12 25 mediating mediate VBG cord-346917-5dgnj11a 12 26 a a DT cord-346917-5dgnj11a 12 27 proinflammatory proinflammatory JJ cord-346917-5dgnj11a 12 28 " " `` cord-346917-5dgnj11a 12 29 cytokine cytokine NN cord-346917-5dgnj11a 12 30 storm storm NN cord-346917-5dgnj11a 12 31 " " '' cord-346917-5dgnj11a 12 32 may may MD cord-346917-5dgnj11a 12 33 be be VB cord-346917-5dgnj11a 12 34 key key JJ cord-346917-5dgnj11a 12 35 players player NNS cord-346917-5dgnj11a 12 36 in in IN cord-346917-5dgnj11a 12 37 COVID-19 covid-19 JJ cord-346917-5dgnj11a 12 38 pathogenesis pathogenesis NN cord-346917-5dgnj11a 12 39 . . . cord-346917-5dgnj11a 13 1 While while IN cord-346917-5dgnj11a 13 2 " " `` cord-346917-5dgnj11a 13 3 cytokine cytokine NN cord-346917-5dgnj11a 13 4 storms storm NNS cord-346917-5dgnj11a 13 5 " " '' cord-346917-5dgnj11a 13 6 have have VBP cord-346917-5dgnj11a 13 7 long long RB cord-346917-5dgnj11a 13 8 been be VBN cord-346917-5dgnj11a 13 9 associated associate VBN cord-346917-5dgnj11a 13 10 with with IN cord-346917-5dgnj11a 13 11 acute acute JJ cord-346917-5dgnj11a 13 12 respiratory respiratory JJ cord-346917-5dgnj11a 13 13 distress distress NN cord-346917-5dgnj11a 13 14 syndrome syndrome NN cord-346917-5dgnj11a 13 15 ( ( -LRB- cord-346917-5dgnj11a 13 16 ARDS ARDS NNP cord-346917-5dgnj11a 13 17 ) ) -RRB- cord-346917-5dgnj11a 13 18 caused cause VBN cord-346917-5dgnj11a 13 19 by by IN cord-346917-5dgnj11a 13 20 SARS SARS NNP cord-346917-5dgnj11a 13 21 coronavirus coronavirus NN cord-346917-5dgnj11a 13 22 ( ( -LRB- cord-346917-5dgnj11a 13 23 SARS SARS NNP cord-346917-5dgnj11a 13 24 - - HYPH cord-346917-5dgnj11a 13 25 CoV CoV NNP cord-346917-5dgnj11a 13 26 ) ) -RRB- cord-346917-5dgnj11a 13 27 and and CC cord-346917-5dgnj11a 13 28 MERS MERS NNP cord-346917-5dgnj11a 13 29 coronavirus coronavirus NN cord-346917-5dgnj11a 13 30 ( ( -LRB- cord-346917-5dgnj11a 13 31 MERS MERS NNP cord-346917-5dgnj11a 13 32 - - HYPH cord-346917-5dgnj11a 13 33 CoV CoV NNP cord-346917-5dgnj11a 13 34 ) ) -RRB- cord-346917-5dgnj11a 14 1 [ [ -LRB- cord-346917-5dgnj11a 14 2 2 2 CD cord-346917-5dgnj11a 14 3 ] ] -RRB- cord-346917-5dgnj11a 14 4 , , , cord-346917-5dgnj11a 14 5 pro pro JJ cord-346917-5dgnj11a 14 6 - - JJ cord-346917-5dgnj11a 14 7 inflammatory inflammatory JJ cord-346917-5dgnj11a 14 8 cytokine cytokine NN cord-346917-5dgnj11a 14 9 dynamics dynamic NNS cord-346917-5dgnj11a 14 10 in in IN cord-346917-5dgnj11a 14 11 the the DT cord-346917-5dgnj11a 14 12 context context NN cord-346917-5dgnj11a 14 13 of of IN cord-346917-5dgnj11a 14 14 cellular cellular JJ cord-346917-5dgnj11a 14 15 immune immune JJ cord-346917-5dgnj11a 14 16 responses response NNS cord-346917-5dgnj11a 14 17 in in IN cord-346917-5dgnj11a 14 18 COVID-19 COVID-19 NNP cord-346917-5dgnj11a 14 19 have have VBP cord-346917-5dgnj11a 14 20 not not RB cord-346917-5dgnj11a 14 21 been be VBN cord-346917-5dgnj11a 14 22 well well RB cord-346917-5dgnj11a 14 23 - - HYPH cord-346917-5dgnj11a 14 24 characterized characterize VBN cord-346917-5dgnj11a 14 25 . . . cord-346917-5dgnj11a 15 1 This this DT cord-346917-5dgnj11a 15 2 study study NN cord-346917-5dgnj11a 15 3 clearly clearly RB cord-346917-5dgnj11a 15 4 demonstrates demonstrate VBZ cord-346917-5dgnj11a 15 5 that that IN cord-346917-5dgnj11a 15 6 severe severe JJ cord-346917-5dgnj11a 15 7 COVID-19 covid-19 NN cord-346917-5dgnj11a 15 8 is be VBZ cord-346917-5dgnj11a 15 9 associated associate VBN cord-346917-5dgnj11a 15 10 with with IN cord-346917-5dgnj11a 15 11 significant significant JJ cord-346917-5dgnj11a 15 12 increases increase NNS cord-346917-5dgnj11a 15 13 in in IN cord-346917-5dgnj11a 15 14 pro pro JJ cord-346917-5dgnj11a 15 15 - - JJ cord-346917-5dgnj11a 15 16 inflammatory inflammatory JJ cord-346917-5dgnj11a 15 17 cytokines cytokine NNS cord-346917-5dgnj11a 15 18 such such JJ cord-346917-5dgnj11a 15 19 as as IN cord-346917-5dgnj11a 15 20 IL-6 IL-6 NNP cord-346917-5dgnj11a 15 21 as as RB cord-346917-5dgnj11a 15 22 well well RB cord-346917-5dgnj11a 15 23 as as IN cord-346917-5dgnj11a 15 24 significant significant JJ cord-346917-5dgnj11a 15 25 reductions reduction NNS cord-346917-5dgnj11a 15 26 in in IN cord-346917-5dgnj11a 15 27 CD8 CD8 NNP cord-346917-5dgnj11a 15 28 + + CC cord-346917-5dgnj11a 15 29 T T NNP cord-346917-5dgnj11a 15 30 cells cell NNS cord-346917-5dgnj11a 15 31 . . . cord-346917-5dgnj11a 16 1 Th1 th1 CD cord-346917-5dgnj11a 16 2 antiviral antiviral JJ cord-346917-5dgnj11a 16 3 responses response NNS cord-346917-5dgnj11a 16 4 appear appear VBP cord-346917-5dgnj11a 16 5 to to TO cord-346917-5dgnj11a 16 6 be be VB cord-346917-5dgnj11a 16 7 suppressed suppress VBN cord-346917-5dgnj11a 16 8 , , , cord-346917-5dgnj11a 16 9 which which WDT cord-346917-5dgnj11a 16 10 is be VBZ cord-346917-5dgnj11a 16 11 supported support VBN cord-346917-5dgnj11a 16 12 by by IN cord-346917-5dgnj11a 16 13 increases increase NNS cord-346917-5dgnj11a 16 14 in in IN cord-346917-5dgnj11a 16 15 the the DT cord-346917-5dgnj11a 16 16 Th2 th2 CD cord-346917-5dgnj11a 16 17 cytokine cytokine NN cord-346917-5dgnj11a 16 18 IL-10 IL-10 NNP cord-346917-5dgnj11a 16 19 . . . cord-346917-5dgnj11a 17 1 A a DT cord-346917-5dgnj11a 17 2 recent recent JJ cord-346917-5dgnj11a 17 3 study study NN cord-346917-5dgnj11a 17 4 in in IN cord-346917-5dgnj11a 17 5 21 21 CD cord-346917-5dgnj11a 17 6 patients patient NNS cord-346917-5dgnj11a 17 7 also also RB cord-346917-5dgnj11a 17 8 demonstrated demonstrate VBD cord-346917-5dgnj11a 17 9 that that IN cord-346917-5dgnj11a 17 10 COVID-19 COVID-19 NNP cord-346917-5dgnj11a 17 11 induced induce VBN cord-346917-5dgnj11a 17 12 increases increase NNS cord-346917-5dgnj11a 17 13 in in IN cord-346917-5dgnj11a 17 14 IL-6 IL-6 NNP cord-346917-5dgnj11a 17 15 and and CC cord-346917-5dgnj11a 17 16 IL-10 IL-10 NNP cord-346917-5dgnj11a 17 17 with with IN cord-346917-5dgnj11a 17 18 corresponding corresponding JJ cord-346917-5dgnj11a 17 19 lymphopenia lymphopenia NNP cord-346917-5dgnj11a 17 20 [ [ -LRB- cord-346917-5dgnj11a 17 21 3 3 CD cord-346917-5dgnj11a 17 22 ] ] -RRB- cord-346917-5dgnj11a 17 23 . . . cord-346917-5dgnj11a 18 1 These these DT cord-346917-5dgnj11a 18 2 data datum NNS cord-346917-5dgnj11a 18 3 indicate indicate VBP cord-346917-5dgnj11a 18 4 that that IN cord-346917-5dgnj11a 18 5 cytokine cytokine NN cord-346917-5dgnj11a 18 6 storms storm NNS cord-346917-5dgnj11a 18 7 may may MD cord-346917-5dgnj11a 18 8 , , , cord-346917-5dgnj11a 18 9 in in IN cord-346917-5dgnj11a 18 10 concert concert NN cord-346917-5dgnj11a 18 11 with with IN cord-346917-5dgnj11a 18 12 suppressed suppress VBN cord-346917-5dgnj11a 18 13 Th1 th1 NN cord-346917-5dgnj11a 18 14 antiviral antiviral JJ cord-346917-5dgnj11a 18 15 adaptive adaptive JJ cord-346917-5dgnj11a 18 16 responses response NNS cord-346917-5dgnj11a 18 17 , , , cord-346917-5dgnj11a 18 18 underlie underlie VBP cord-346917-5dgnj11a 18 19 the the DT cord-346917-5dgnj11a 18 20 pathogenesis pathogenesis NN cord-346917-5dgnj11a 18 21 of of IN cord-346917-5dgnj11a 18 22 severe severe JJ cord-346917-5dgnj11a 18 23 COVID-19 covid-19 JJ cord-346917-5dgnj11a 18 24 disease disease NN cord-346917-5dgnj11a 18 25 . . . cord-346917-5dgnj11a 19 1 These these DT cord-346917-5dgnj11a 19 2 findings finding NNS cord-346917-5dgnj11a 19 3 are be VBP cord-346917-5dgnj11a 19 4 valuable valuable JJ cord-346917-5dgnj11a 19 5 for for IN cord-346917-5dgnj11a 19 6 clinicians clinician NNS cord-346917-5dgnj11a 19 7 as as IN cord-346917-5dgnj11a 19 8 it -PRON- PRP cord-346917-5dgnj11a 19 9 further further RB cord-346917-5dgnj11a 19 10 supports support VBZ cord-346917-5dgnj11a 19 11 the the DT cord-346917-5dgnj11a 19 12 significant significant JJ cord-346917-5dgnj11a 19 13 effect effect NN cord-346917-5dgnj11a 19 14 SARS SARS NNP cord-346917-5dgnj11a 19 15 - - HYPH cord-346917-5dgnj11a 19 16 CoV-2 CoV-2 NNP cord-346917-5dgnj11a 19 17 has have VBZ cord-346917-5dgnj11a 19 18 on on IN cord-346917-5dgnj11a 19 19 the the DT cord-346917-5dgnj11a 19 20 systemic systemic JJ cord-346917-5dgnj11a 19 21 inflammatory inflammatory JJ cord-346917-5dgnj11a 19 22 response response NN cord-346917-5dgnj11a 19 23 and and CC cord-346917-5dgnj11a 19 24 gives give VBZ cord-346917-5dgnj11a 19 25 insight insight NN cord-346917-5dgnj11a 19 26 on on IN cord-346917-5dgnj11a 19 27 how how WRB cord-346917-5dgnj11a 19 28 to to TO cord-346917-5dgnj11a 19 29 identify identify VB cord-346917-5dgnj11a 19 30 patients patient NNS cord-346917-5dgnj11a 19 31 at at IN cord-346917-5dgnj11a 19 32 risk risk NN cord-346917-5dgnj11a 19 33 for for IN cord-346917-5dgnj11a 19 34 severe severe JJ cord-346917-5dgnj11a 19 35 disease disease NN cord-346917-5dgnj11a 19 36 . . . cord-346917-5dgnj11a 20 1 It -PRON- PRP cord-346917-5dgnj11a 20 2 demonstrates demonstrate VBZ cord-346917-5dgnj11a 20 3 potentially potentially RB cord-346917-5dgnj11a 20 4 critical critical JJ cord-346917-5dgnj11a 20 5 roles role NNS cord-346917-5dgnj11a 20 6 for for IN cord-346917-5dgnj11a 20 7 IL-2 IL-2 NNP cord-346917-5dgnj11a 20 8 , , , cord-346917-5dgnj11a 20 9 IL-6 IL-6 NNP cord-346917-5dgnj11a 20 10 , , , cord-346917-5dgnj11a 20 11 IL-10 IL-10 NNP cord-346917-5dgnj11a 20 12 , , , cord-346917-5dgnj11a 20 13 and and CC cord-346917-5dgnj11a 20 14 IFN IFN NNP cord-346917-5dgnj11a 20 15 - - HYPH cord-346917-5dgnj11a 20 16 g g NNP cord-346917-5dgnj11a 20 17 in in IN cord-346917-5dgnj11a 20 18 severe severe JJ cord-346917-5dgnj11a 20 19 disease disease NN cord-346917-5dgnj11a 20 20 , , , cord-346917-5dgnj11a 20 21 suggesting suggest VBG cord-346917-5dgnj11a 20 22 that that IN cord-346917-5dgnj11a 20 23 the the DT cord-346917-5dgnj11a 20 24 magnitude magnitude NN cord-346917-5dgnj11a 20 25 of of IN cord-346917-5dgnj11a 20 26 the the DT cord-346917-5dgnj11a 20 27 cytokine cytokine NN cord-346917-5dgnj11a 20 28 storm storm NN cord-346917-5dgnj11a 20 29 is be VBZ cord-346917-5dgnj11a 20 30 associated associate VBN cord-346917-5dgnj11a 20 31 with with IN cord-346917-5dgnj11a 20 32 severity severity NN cord-346917-5dgnj11a 20 33 of of IN cord-346917-5dgnj11a 20 34 disease disease NN cord-346917-5dgnj11a 20 35 . . . cord-346917-5dgnj11a 21 1 Mean Mean NNP cord-346917-5dgnj11a 21 2 IL-6 IL-6 NNP cord-346917-5dgnj11a 21 3 concentrations concentration NNS cord-346917-5dgnj11a 21 4 have have VBP cord-346917-5dgnj11a 21 5 been be VBN cord-346917-5dgnj11a 21 6 shown show VBN cord-346917-5dgnj11a 21 7 to to TO cord-346917-5dgnj11a 21 8 be be VB cord-346917-5dgnj11a 21 9 2.9 2.9 CD cord-346917-5dgnj11a 21 10 times time NNS cord-346917-5dgnj11a 21 11 higher high JJR cord-346917-5dgnj11a 21 12 in in IN cord-346917-5dgnj11a 21 13 patients patient NNS cord-346917-5dgnj11a 21 14 with with IN cord-346917-5dgnj11a 21 15 severe severe JJ cord-346917-5dgnj11a 21 16 disease disease NN cord-346917-5dgnj11a 21 17 and and CC cord-346917-5dgnj11a 21 18 maximal maximal JJ cord-346917-5dgnj11a 21 19 IL-6 IL-6 NNP cord-346917-5dgnj11a 21 20 highly highly RB cord-346917-5dgnj11a 21 21 predictive predictive JJ cord-346917-5dgnj11a 21 22 of of IN cord-346917-5dgnj11a 21 23 respiratory respiratory JJ cord-346917-5dgnj11a 21 24 failure failure NN cord-346917-5dgnj11a 21 25 [ [ -LRB- cord-346917-5dgnj11a 21 26 4 4 CD cord-346917-5dgnj11a 21 27 , , , cord-346917-5dgnj11a 21 28 5 5 CD cord-346917-5dgnj11a 21 29 ] ] -RRB- cord-346917-5dgnj11a 21 30 . . . cord-346917-5dgnj11a 22 1 These these DT cord-346917-5dgnj11a 22 2 data datum NNS cord-346917-5dgnj11a 22 3 also also RB cord-346917-5dgnj11a 22 4 suggest suggest VBP cord-346917-5dgnj11a 22 5 that that IN cord-346917-5dgnj11a 22 6 monitoring monitor VBG cord-346917-5dgnj11a 22 7 N8R n8r CD cord-346917-5dgnj11a 22 8 and and CC cord-346917-5dgnj11a 22 9 NLR NLR NNP cord-346917-5dgnj11a 22 10 over over IN cord-346917-5dgnj11a 22 11 time time NN cord-346917-5dgnj11a 22 12 could could MD cord-346917-5dgnj11a 22 13 be be VB cord-346917-5dgnj11a 22 14 a a DT cord-346917-5dgnj11a 22 15 way way NN cord-346917-5dgnj11a 22 16 to to TO cord-346917-5dgnj11a 22 17 identify identify VB cord-346917-5dgnj11a 22 18 patients patient NNS cord-346917-5dgnj11a 22 19 early early RB cord-346917-5dgnj11a 22 20 on on IN cord-346917-5dgnj11a 22 21 at at IN cord-346917-5dgnj11a 22 22 risk risk NN cord-346917-5dgnj11a 22 23 for for IN cord-346917-5dgnj11a 22 24 developing develop VBG cord-346917-5dgnj11a 22 25 severe severe JJ cord-346917-5dgnj11a 22 26 disease disease NN cord-346917-5dgnj11a 22 27 [ [ -LRB- cord-346917-5dgnj11a 22 28 6 6 CD cord-346917-5dgnj11a 22 29 ] ] -RRB- cord-346917-5dgnj11a 22 30 . . . cord-346917-5dgnj11a 23 1 Understanding understand VBG cord-346917-5dgnj11a 23 2 how how WRB cord-346917-5dgnj11a 23 3 to to TO cord-346917-5dgnj11a 23 4 identify identify VB cord-346917-5dgnj11a 23 5 which which WDT cord-346917-5dgnj11a 23 6 patients patient NNS cord-346917-5dgnj11a 23 7 who who WP cord-346917-5dgnj11a 23 8 present present VBP cord-346917-5dgnj11a 23 9 with with IN cord-346917-5dgnj11a 23 10 COVID-19 COVID-19 NNP cord-346917-5dgnj11a 23 11 will will MD cord-346917-5dgnj11a 23 12 go go VB cord-346917-5dgnj11a 23 13 on on RP cord-346917-5dgnj11a 23 14 to to TO cord-346917-5dgnj11a 23 15 develop develop VB cord-346917-5dgnj11a 23 16 severe severe JJ cord-346917-5dgnj11a 23 17 disease disease NN cord-346917-5dgnj11a 23 18 is be VBZ cord-346917-5dgnj11a 23 19 of of IN cord-346917-5dgnj11a 23 20 paramount paramount JJ cord-346917-5dgnj11a 23 21 importance importance NN cord-346917-5dgnj11a 23 22 to to IN cord-346917-5dgnj11a 23 23 clinicians clinician NNS cord-346917-5dgnj11a 23 24 . . . cord-346917-5dgnj11a 24 1 Monitoring monitor VBG cord-346917-5dgnj11a 24 2 N8R n8r CD cord-346917-5dgnj11a 24 3 and and CC cord-346917-5dgnj11a 24 4 NLR NLR NNP cord-346917-5dgnj11a 24 5 over over IN cord-346917-5dgnj11a 24 6 time time NN cord-346917-5dgnj11a 24 7 may may MD cord-346917-5dgnj11a 24 8 assist assist VB cord-346917-5dgnj11a 24 9 frontline frontline JJ cord-346917-5dgnj11a 24 10 clinicians clinician NNS cord-346917-5dgnj11a 24 11 in in IN cord-346917-5dgnj11a 24 12 identifying identify VBG cord-346917-5dgnj11a 24 13 those those DT cord-346917-5dgnj11a 24 14 at at IN cord-346917-5dgnj11a 24 15 greatest great JJS cord-346917-5dgnj11a 24 16 risk risk NN cord-346917-5dgnj11a 24 17 for for IN cord-346917-5dgnj11a 24 18 developing develop VBG cord-346917-5dgnj11a 24 19 severe severe JJ cord-346917-5dgnj11a 24 20 COVID-19 covid-19 NN cord-346917-5dgnj11a 24 21 and and CC cord-346917-5dgnj11a 24 22 prompt prompt VB cord-346917-5dgnj11a 24 23 them -PRON- PRP cord-346917-5dgnj11a 24 24 to to TO cord-346917-5dgnj11a 24 25 institute institute VB cord-346917-5dgnj11a 24 26 supportive supportive JJ cord-346917-5dgnj11a 24 27 care care NN cord-346917-5dgnj11a 24 28 earlier early RBR cord-346917-5dgnj11a 24 29 or or CC cord-346917-5dgnj11a 24 30 initiate initiate VB cord-346917-5dgnj11a 24 31 transfer transfer NN cord-346917-5dgnj11a 24 32 to to IN cord-346917-5dgnj11a 24 33 a a DT cord-346917-5dgnj11a 24 34 higher high JJR cord-346917-5dgnj11a 24 35 level level NN cord-346917-5dgnj11a 24 36 of of IN cord-346917-5dgnj11a 24 37 care care NN cord-346917-5dgnj11a 24 38 [ [ -LRB- cord-346917-5dgnj11a 24 39 6 6 CD cord-346917-5dgnj11a 24 40 ] ] -RRB- cord-346917-5dgnj11a 24 41 . . . cord-346917-5dgnj11a 25 1 Appreciating appreciate VBG cord-346917-5dgnj11a 25 2 the the DT cord-346917-5dgnj11a 25 3 role role NN cord-346917-5dgnj11a 25 4 of of IN cord-346917-5dgnj11a 25 5 pro pro JJ cord-346917-5dgnj11a 25 6 - - JJ cord-346917-5dgnj11a 25 7 inflammatory inflammatory JJ cord-346917-5dgnj11a 25 8 cytokines cytokine NNS cord-346917-5dgnj11a 25 9 in in IN cord-346917-5dgnj11a 25 10 the the DT cord-346917-5dgnj11a 25 11 pathogenesis pathogenesis NN cord-346917-5dgnj11a 25 12 of of IN cord-346917-5dgnj11a 25 13 the the DT cord-346917-5dgnj11a 25 14 disease disease NN cord-346917-5dgnj11a 25 15 is be VBZ cord-346917-5dgnj11a 25 16 important important JJ cord-346917-5dgnj11a 25 17 as as IN cord-346917-5dgnj11a 25 18 the the DT cord-346917-5dgnj11a 25 19 scientific scientific JJ cord-346917-5dgnj11a 25 20 community community NN cord-346917-5dgnj11a 25 21 develops develop VBZ cord-346917-5dgnj11a 25 22 therapeutics therapeutic NNS cord-346917-5dgnj11a 25 23 to to TO cord-346917-5dgnj11a 25 24 treat treat VB cord-346917-5dgnj11a 25 25 patients patient NNS cord-346917-5dgnj11a 25 26 . . . cord-346917-5dgnj11a 26 1 IL-6 IL-6 NNP cord-346917-5dgnj11a 26 2 inhibitors inhibitor NNS cord-346917-5dgnj11a 26 3 such such JJ cord-346917-5dgnj11a 26 4 as as IN cord-346917-5dgnj11a 26 5 tocilizumab tocilizumab NNP cord-346917-5dgnj11a 26 6 and and CC cord-346917-5dgnj11a 26 7 siltuximab siltuximab NNS cord-346917-5dgnj11a 26 8 are be VBP cord-346917-5dgnj11a 26 9 already already RB cord-346917-5dgnj11a 26 10 being be VBG cord-346917-5dgnj11a 26 11 used use VBN cord-346917-5dgnj11a 26 12 in in IN cord-346917-5dgnj11a 26 13 the the DT cord-346917-5dgnj11a 26 14 treatment treatment NN cord-346917-5dgnj11a 26 15 of of IN cord-346917-5dgnj11a 26 16 patients patient NNS cord-346917-5dgnj11a 26 17 with with IN cord-346917-5dgnj11a 26 18 severe severe JJ cord-346917-5dgnj11a 26 19 COVID-19 covid-19 NN cord-346917-5dgnj11a 26 20 in in IN cord-346917-5dgnj11a 26 21 hopes hope NNS cord-346917-5dgnj11a 26 22 of of IN cord-346917-5dgnj11a 26 23 suppressing suppress VBG cord-346917-5dgnj11a 26 24 inflammatory inflammatory JJ cord-346917-5dgnj11a 26 25 responses response NNS cord-346917-5dgnj11a 26 26 and and CC cord-346917-5dgnj11a 26 27 have have VBP cord-346917-5dgnj11a 26 28 been be VBN cord-346917-5dgnj11a 26 29 adopted adopt VBN cord-346917-5dgnj11a 26 30 in in IN cord-346917-5dgnj11a 26 31 the the DT cord-346917-5dgnj11a 26 32 most most RBS cord-346917-5dgnj11a 26 33 recent recent JJ cord-346917-5dgnj11a 26 34 Chinese Chinese NNP cord-346917-5dgnj11a 26 35 National National NNP cord-346917-5dgnj11a 26 36 Health Health NNP cord-346917-5dgnj11a 26 37 Commission Commission NNP cord-346917-5dgnj11a 26 38 Novel Novel NNP cord-346917-5dgnj11a 26 39 Coronavirus Coronavirus NNP cord-346917-5dgnj11a 26 40 Pneumonia Pneumonia NNP cord-346917-5dgnj11a 26 41 guidelines guideline NNS cord-346917-5dgnj11a 26 42 [ [ -LRB- cord-346917-5dgnj11a 26 43 5 5 CD cord-346917-5dgnj11a 26 44 , , , cord-346917-5dgnj11a 26 45 7 7 CD cord-346917-5dgnj11a 26 46 ] ] -RRB- cord-346917-5dgnj11a 26 47 . . . cord-346917-5dgnj11a 27 1 Additionally additionally RB cord-346917-5dgnj11a 27 2 , , , cord-346917-5dgnj11a 27 3 levels level NNS cord-346917-5dgnj11a 27 4 of of IN cord-346917-5dgnj11a 27 5 fibrinogen fibrinogen NN cord-346917-5dgnj11a 27 6 , , , cord-346917-5dgnj11a 27 7 D d NN cord-346917-5dgnj11a 27 8 - - HYPH cord-346917-5dgnj11a 27 9 dimer dimer NN cord-346917-5dgnj11a 27 10 , , , cord-346917-5dgnj11a 27 11 C C NNP cord-346917-5dgnj11a 27 12 - - HYPH cord-346917-5dgnj11a 27 13 reactive reactive JJ cord-346917-5dgnj11a 27 14 protein protein NN cord-346917-5dgnj11a 27 15 , , , cord-346917-5dgnj11a 27 16 and and CC cord-346917-5dgnj11a 27 17 ferritin ferritin NN cord-346917-5dgnj11a 27 18 were be VBD cord-346917-5dgnj11a 27 19 found find VBN cord-346917-5dgnj11a 27 20 to to TO cord-346917-5dgnj11a 27 21 be be VB cord-346917-5dgnj11a 27 22 significantly significantly RB cord-346917-5dgnj11a 27 23 higher high JJR cord-346917-5dgnj11a 27 24 in in IN cord-346917-5dgnj11a 27 25 patients patient NNS cord-346917-5dgnj11a 27 26 with with IN cord-346917-5dgnj11a 27 27 severe severe JJ cord-346917-5dgnj11a 27 28 diseases disease NNS cord-346917-5dgnj11a 27 29 compared compare VBN cord-346917-5dgnj11a 27 30 to to IN cord-346917-5dgnj11a 27 31 mild mild JJ cord-346917-5dgnj11a 27 32 patients patient NNS cord-346917-5dgnj11a 27 33 and and CC cord-346917-5dgnj11a 27 34 are be VBP cord-346917-5dgnj11a 27 35 other other JJ cord-346917-5dgnj11a 27 36 potential potential JJ cord-346917-5dgnj11a 27 37 laboratory laboratory NN cord-346917-5dgnj11a 27 38 markers marker NNS cord-346917-5dgnj11a 27 39 clinicians clinician NNS cord-346917-5dgnj11a 27 40 can can MD cord-346917-5dgnj11a 27 41 monitor monitor VB cord-346917-5dgnj11a 27 42 over over IN cord-346917-5dgnj11a 27 43 time time NN cord-346917-5dgnj11a 27 44 to to TO cord-346917-5dgnj11a 27 45 assess assess VB cord-346917-5dgnj11a 27 46 how how WRB cord-346917-5dgnj11a 27 47 individuals individual NNS cord-346917-5dgnj11a 27 48 are be VBP cord-346917-5dgnj11a 27 49 responding respond VBG cord-346917-5dgnj11a 27 50 [ [ -LRB- cord-346917-5dgnj11a 27 51 8 8 CD cord-346917-5dgnj11a 27 52 ] ] -RRB- cord-346917-5dgnj11a 27 53 . . . cord-346917-5dgnj11a 28 1 This this DT cord-346917-5dgnj11a 28 2 is be VBZ cord-346917-5dgnj11a 28 3 consistent consistent JJ cord-346917-5dgnj11a 28 4 with with IN cord-346917-5dgnj11a 28 5 prior prior JJ cord-346917-5dgnj11a 28 6 reports report NNS cord-346917-5dgnj11a 28 7 that that IN cord-346917-5dgnj11a 28 8 higher high JJR cord-346917-5dgnj11a 28 9 levels level NNS cord-346917-5dgnj11a 28 10 of of IN cord-346917-5dgnj11a 28 11 C c NN cord-346917-5dgnj11a 28 12 - - HYPH cord-346917-5dgnj11a 28 13 reactive reactive JJ cord-346917-5dgnj11a 28 14 protein protein NN cord-346917-5dgnj11a 28 15 , , , cord-346917-5dgnj11a 28 16 ferritin ferritin NN cord-346917-5dgnj11a 28 17 and and CC cord-346917-5dgnj11a 28 18 D d NN cord-346917-5dgnj11a 28 19 - - HYPH cord-346917-5dgnj11a 28 20 dimer dimer NN cord-346917-5dgnj11a 28 21 were be VBD cord-346917-5dgnj11a 28 22 associated associate VBN cord-346917-5dgnj11a 28 23 with with IN cord-346917-5dgnj11a 28 24 severe severe JJ cord-346917-5dgnj11a 28 25 COVID-19 covid-19 JJ cord-346917-5dgnj11a 28 26 [ [ -LRB- cord-346917-5dgnj11a 28 27 3 3 CD cord-346917-5dgnj11a 28 28 ] ] -RRB- cord-346917-5dgnj11a 28 29 . . . cord-346917-5dgnj11a 29 1 This this DT cord-346917-5dgnj11a 29 2 study study NN cord-346917-5dgnj11a 29 3 was be VBD cord-346917-5dgnj11a 29 4 limited limit VBN cord-346917-5dgnj11a 29 5 to to IN cord-346917-5dgnj11a 29 6 40 40 CD cord-346917-5dgnj11a 29 7 COVID-19 covid-19 CD cord-346917-5dgnj11a 29 8 patients patient NNS cord-346917-5dgnj11a 29 9 , , , cord-346917-5dgnj11a 29 10 thus thus RB cord-346917-5dgnj11a 29 11 limiting limit VBG cord-346917-5dgnj11a 29 12 the the DT cord-346917-5dgnj11a 29 13 applicability applicability NN cord-346917-5dgnj11a 29 14 to to IN cord-346917-5dgnj11a 29 15 larger large JJR cord-346917-5dgnj11a 29 16 populations population NNS cord-346917-5dgnj11a 29 17 . . . cord-346917-5dgnj11a 30 1 Furthermore furthermore RB cord-346917-5dgnj11a 30 2 , , , cord-346917-5dgnj11a 30 3 five five CD cord-346917-5dgnj11a 30 4 of of IN cord-346917-5dgnj11a 30 5 the the DT cord-346917-5dgnj11a 30 6 severe severe JJ cord-346917-5dgnj11a 30 7 patients patient NNS cord-346917-5dgnj11a 30 8 had have VBD cord-346917-5dgnj11a 30 9 fungal fungal JJ cord-346917-5dgnj11a 30 10 or or CC cord-346917-5dgnj11a 30 11 bacterial bacterial JJ cord-346917-5dgnj11a 30 12 co co NNS cord-346917-5dgnj11a 30 13 - - NNS cord-346917-5dgnj11a 30 14 infections infection NNS cord-346917-5dgnj11a 30 15 , , , cord-346917-5dgnj11a 30 16 which which WDT cord-346917-5dgnj11a 30 17 likely likely RB cord-346917-5dgnj11a 30 18 confound confound VBP cord-346917-5dgnj11a 30 19 associations association NNS cord-346917-5dgnj11a 30 20 of of IN cord-346917-5dgnj11a 30 21 inflammatory inflammatory JJ cord-346917-5dgnj11a 30 22 dysfunction dysfunction NN cord-346917-5dgnj11a 30 23 with with IN cord-346917-5dgnj11a 30 24 specific specific JJ cord-346917-5dgnj11a 30 25 features feature NNS cord-346917-5dgnj11a 30 26 of of IN cord-346917-5dgnj11a 30 27 COVID-19 covid-19 JJ cord-346917-5dgnj11a 30 28 disease disease NN cord-346917-5dgnj11a 30 29 . . . cord-346917-5dgnj11a 31 1 Although although IN cord-346917-5dgnj11a 31 2 N8R n8r CD cord-346917-5dgnj11a 31 3 and and CC cord-346917-5dgnj11a 31 4 NLR NLR NNP cord-346917-5dgnj11a 31 5 remained remain VBD cord-346917-5dgnj11a 31 6 significant significant JJ cord-346917-5dgnj11a 31 7 predictors predictor NNS cord-346917-5dgnj11a 31 8 of of IN cord-346917-5dgnj11a 31 9 COVID-19 covid-19 JJ cord-346917-5dgnj11a 31 10 outcome outcome NN cord-346917-5dgnj11a 31 11 when when WRB cord-346917-5dgnj11a 31 12 the the DT cord-346917-5dgnj11a 31 13 patients patient NNS cord-346917-5dgnj11a 31 14 with with IN cord-346917-5dgnj11a 31 15 fungal fungal JJ cord-346917-5dgnj11a 31 16 infections infection NNS cord-346917-5dgnj11a 31 17 were be VBD cord-346917-5dgnj11a 31 18 removed remove VBN cord-346917-5dgnj11a 31 19 , , , cord-346917-5dgnj11a 31 20 larger large JJR cord-346917-5dgnj11a 31 21 studies study NNS cord-346917-5dgnj11a 31 22 that that WDT cord-346917-5dgnj11a 31 23 can can MD cord-346917-5dgnj11a 31 24 account account VB cord-346917-5dgnj11a 31 25 for for IN cord-346917-5dgnj11a 31 26 variables variable NNS cord-346917-5dgnj11a 31 27 introduced introduce VBN cord-346917-5dgnj11a 31 28 by by IN cord-346917-5dgnj11a 31 29 co co NNS cord-346917-5dgnj11a 31 30 - - NNS cord-346917-5dgnj11a 31 31 infections infection NNS cord-346917-5dgnj11a 31 32 are be VBP cord-346917-5dgnj11a 31 33 needed need VBN cord-346917-5dgnj11a 31 34 . . . cord-346917-5dgnj11a 32 1 A a DT cord-346917-5dgnj11a 32 2 subset subset NN cord-346917-5dgnj11a 32 3 of of IN cord-346917-5dgnj11a 32 4 patients patient NNS cord-346917-5dgnj11a 32 5 received receive VBD cord-346917-5dgnj11a 32 6 methylprednisolone methylprednisolone NN cord-346917-5dgnj11a 32 7 , , , cord-346917-5dgnj11a 32 8 a a DT cord-346917-5dgnj11a 32 9 corticosteroid corticosteroid NN cord-346917-5dgnj11a 32 10 with with IN cord-346917-5dgnj11a 32 11 known know VBN cord-346917-5dgnj11a 32 12 DOI doi NN cord-346917-5dgnj11a 32 13 of of IN cord-346917-5dgnj11a 32 14 original original JJ cord-346917-5dgnj11a 32 15 article article NN cord-346917-5dgnj11a 32 16 : : : cord-346917-5dgnj11a 32 17 http://dx.doi.org/10.1016/j.ebiom.2020.102763 http://dx.doi.org/10.1016/j.ebiom.2020.102763 NNP cord-346917-5dgnj11a 32 18 . . . cord-346917-5dgnj11a 33 1 Longitudinal longitudinal JJ cord-346917-5dgnj11a 33 2 characteristics characteristic NNS cord-346917-5dgnj11a 33 3 of of IN cord-346917-5dgnj11a 33 4 lymphocyte lymphocyte NN cord-346917-5dgnj11a 33 5 responses response NNS cord-346917-5dgnj11a 33 6 and and CC cord-346917-5dgnj11a 33 7 cytokine cytokine NN cord-346917-5dgnj11a 33 8 profiles profile NNS cord-346917-5dgnj11a 33 9 in in IN cord-346917-5dgnj11a 33 10 the the DT cord-346917-5dgnj11a 33 11 peripheral peripheral JJ cord-346917-5dgnj11a 33 12 blood blood NN cord-346917-5dgnj11a 33 13 of of IN cord-346917-5dgnj11a 33 14 SARS SARS NNP cord-346917-5dgnj11a 33 15 - - HYPH cord-346917-5dgnj11a 33 16 CoV-2 CoV-2 NNP cord-346917-5dgnj11a 33 17 infected infect VBN cord-346917-5dgnj11a 33 18 patients patient NNS cord-346917-5dgnj11a 33 19 Pathogenic pathogenic JJ cord-346917-5dgnj11a 33 20 human human JJ cord-346917-5dgnj11a 33 21 coronavirus coronavirus NN cord-346917-5dgnj11a 33 22 infections infection NNS cord-346917-5dgnj11a 33 23 : : : cord-346917-5dgnj11a 33 24 causes cause NNS cord-346917-5dgnj11a 33 25 and and CC cord-346917-5dgnj11a 33 26 consequences consequence NNS cord-346917-5dgnj11a 33 27 of of IN cord-346917-5dgnj11a 33 28 cytokine cytokine NN cord-346917-5dgnj11a 33 29 storm storm NN cord-346917-5dgnj11a 33 30 and and CC cord-346917-5dgnj11a 33 31 immunopathology immunopathology NN cord-346917-5dgnj11a 33 32 Clinical clinical JJ cord-346917-5dgnj11a 33 33 and and CC cord-346917-5dgnj11a 33 34 immunologic immunologic JJ cord-346917-5dgnj11a 33 35 features feature NNS cord-346917-5dgnj11a 33 36 in in IN cord-346917-5dgnj11a 33 37 severe severe JJ cord-346917-5dgnj11a 33 38 and and CC cord-346917-5dgnj11a 33 39 moderate moderate JJ cord-346917-5dgnj11a 33 40 coronavirus coronavirus NN cord-346917-5dgnj11a 33 41 disease disease NN cord-346917-5dgnj11a 34 1 2019 2019 CD cord-346917-5dgnj11a 34 2 Clinical clinical JJ cord-346917-5dgnj11a 34 3 and and CC cord-346917-5dgnj11a 34 4 biochemical biochemical JJ cord-346917-5dgnj11a 34 5 indexes index NNS cord-346917-5dgnj11a 34 6 from from IN cord-346917-5dgnj11a 34 7 2019-nCoV 2019-ncov CD cord-346917-5dgnj11a 34 8 infected infect VBN cord-346917-5dgnj11a 34 9 patients patient NNS cord-346917-5dgnj11a 34 10 linked link VBN cord-346917-5dgnj11a 34 11 to to IN cord-346917-5dgnj11a 34 12 viral viral JJ cord-346917-5dgnj11a 34 13 loads load NNS cord-346917-5dgnj11a 34 14 and and CC cord-346917-5dgnj11a 34 15 lung lung NN cord-346917-5dgnj11a 34 16 injury injury NN cord-346917-5dgnj11a 34 17 Interleukin-6 Interleukin-6 NNP cord-346917-5dgnj11a 34 18 in in IN cord-346917-5dgnj11a 34 19 COVID-19 COVID-19 NNP cord-346917-5dgnj11a 34 20 : : : cord-346917-5dgnj11a 34 21 a a DT cord-346917-5dgnj11a 34 22 Systematic Systematic NNP cord-346917-5dgnj11a 34 23 Review Review NNP cord-346917-5dgnj11a 34 24 and and CC cord-346917-5dgnj11a 34 25 Meta Meta NNP cord-346917-5dgnj11a 34 26 - - HYPH cord-346917-5dgnj11a 34 27 Analysis Analysis NNP cord-346917-5dgnj11a 34 28 Potential potential JJ cord-346917-5dgnj11a 34 29 factors factor NNS cord-346917-5dgnj11a 34 30 for for IN cord-346917-5dgnj11a 34 31 prediction prediction NN cord-346917-5dgnj11a 34 32 of of IN cord-346917-5dgnj11a 34 33 disease disease NN cord-346917-5dgnj11a 34 34 severity severity NN cord-346917-5dgnj11a 34 35 of of IN cord-346917-5dgnj11a 34 36 COVID-19 covid-19 CD cord-346917-5dgnj11a 34 37 patients patient NNS cord-346917-5dgnj11a 34 38 China China NNP cord-346917-5dgnj11a 34 39 National National NNP cord-346917-5dgnj11a 34 40 Health Health NNP cord-346917-5dgnj11a 34 41 Commission Commission NNP cord-346917-5dgnj11a 34 42 . . . cord-346917-5dgnj11a 35 1 《 《 NNP cord-346917-5dgnj11a 35 2 新型冠状病毒肺炎诊疗方案 新型冠状病毒肺炎诊疗方案 NNP cord-346917-5dgnj11a 35 3 ( ( -LRB- cord-346917-5dgnj11a 35 4 试行第七版 试行第七版 NN cord-346917-5dgnj11a 35 5 ) ) -RRB- cord-346917-5dgnj11a 35 6 》 》 NNP cord-346917-5dgnj11a 36 1 解读 解读 NNP cord-346917-5dgnj11a 36 2 n.d n.d NNP cord-346917-5dgnj11a 36 3 . . . cord-346917-5dgnj11a 37 1 2020 2020 CD cord-346917-5dgnj11a 38 1 The the DT cord-346917-5dgnj11a 38 2 potential potential JJ cord-346917-5dgnj11a 38 3 role role NN cord-346917-5dgnj11a 38 4 of of IN cord-346917-5dgnj11a 38 5 IL-6 IL-6 NNP cord-346917-5dgnj11a 38 6 in in IN cord-346917-5dgnj11a 38 7 monitoring monitor VBG cord-346917-5dgnj11a 38 8 severe severe JJ cord-346917-5dgnj11a 38 9 case case NN cord-346917-5dgnj11a 38 10 of of IN cord-346917-5dgnj11a 38 11 coronavirus coronavirus NN cord-346917-5dgnj11a 38 12 disease disease NN cord-346917-5dgnj11a 38 13 2019 2019 CD cord-346917-5dgnj11a 39 1 The the DT cord-346917-5dgnj11a 39 2 authors author NNS cord-346917-5dgnj11a 39 3 declare declare VBP cord-346917-5dgnj11a 39 4 no no DT cord-346917-5dgnj11a 39 5 conflict conflict NN cord-346917-5dgnj11a 39 6 of of IN cord-346917-5dgnj11a 39 7 interest interest NN cord-346917-5dgnj11a 39 8 . . .