id	sid	tid	token	lemma	pos
cord-345762-khvcoqti	1	1	key	key	NN
cord-345762-khvcoqti	1	2	:	:	:
cord-345762-khvcoqti	1	3	cord-345762-khvcoqti	cord-345762-khvcoqti	.
cord-345762-khvcoqti	2	1	authors	author	NNS
cord-345762-khvcoqti	2	2	:	:	:
cord-345762-khvcoqti	2	3	Scott	Scott	NNP
cord-345762-khvcoqti	2	4	,	,	,
cord-345762-khvcoqti	2	5	Ian	Ian	NNP
cord-345762-khvcoqti	2	6	A.	a.	NN
cord-345762-khvcoqti	2	7	title	title	NN
cord-345762-khvcoqti	2	8	:	:	:
cord-345762-khvcoqti	2	9	COVID‐19	COVID‐19	NNP
cord-345762-khvcoqti	2	10	pandemic	pandemic	NN
cord-345762-khvcoqti	2	11	and	and	CC
cord-345762-khvcoqti	2	12	the	the	DT
cord-345762-khvcoqti	2	13	tension	tension	NN
cord-345762-khvcoqti	2	14	between	between	IN
cord-345762-khvcoqti	2	15	the	the	DT
cord-345762-khvcoqti	2	16	need	need	NN
cord-345762-khvcoqti	2	17	to	to	TO
cord-345762-khvcoqti	2	18	act	act	VB
cord-345762-khvcoqti	2	19	and	and	CC
cord-345762-khvcoqti	2	20	the	the	DT
cord-345762-khvcoqti	2	21	need	need	NN
cord-345762-khvcoqti	2	22	to	to	TO
cord-345762-khvcoqti	2	23	know	know	VB
cord-345762-khvcoqti	2	24	date	date	NN
cord-345762-khvcoqti	2	25	:	:	:
cord-345762-khvcoqti	2	26	2020	2020	CD
cord-345762-khvcoqti	2	27	-	-	HYPH
cord-345762-khvcoqti	2	28	08	08	CD
cord-345762-khvcoqti	2	29	-	-	HYPH
cord-345762-khvcoqti	2	30	06	06	CD
cord-345762-khvcoqti	2	31	journal	journal	NN
cord-345762-khvcoqti	2	32	:	:	:
cord-345762-khvcoqti	2	33	Intern	Intern	NNP
cord-345762-khvcoqti	2	34	Med	Med	NNP
cord-345762-khvcoqti	2	35	J	J	NNP
cord-345762-khvcoqti	2	36	DOI	doi	NN
cord-345762-khvcoqti	2	37	:	:	:
cord-345762-khvcoqti	3	1	10.1111	10.1111	CD
cord-345762-khvcoqti	3	2	/	/	SYM
cord-345762-khvcoqti	3	3	imj.14929	imj.14929	NN
cord-345762-khvcoqti	3	4	sha	sha	NNP
cord-345762-khvcoqti	3	5	:	:	:
cord-345762-khvcoqti	4	1	08be142a3a2d0a52cedfee9bf3420ed3e482acf2	08be142a3a2d0a52cedfee9bf3420ed3e482acf2	CD
cord-345762-khvcoqti	4	2	doc_id	doc_id	CD
cord-345762-khvcoqti	5	1	:	:	:
cord-345762-khvcoqti	5	2	345762	345762	CD
cord-345762-khvcoqti	5	3	cord_uid	cord_uid	NN
cord-345762-khvcoqti	5	4	:	:	:
cord-345762-khvcoqti	6	1	khvcoqti	khvcoqti	NNP
cord-345762-khvcoqti	6	2	nan	nan	NNP
cord-345762-khvcoqti	6	3	Pandemics	Pandemics	NNP
cord-345762-khvcoqti	6	4	associated	associate	VBN
cord-345762-khvcoqti	6	5	with	with	IN
cord-345762-khvcoqti	6	6	a	a	DT
cord-345762-khvcoqti	6	7	deadly	deadly	JJ
cord-345762-khvcoqti	6	8	and	and	CC
cord-345762-khvcoqti	6	9	contagious	contagious	JJ
cord-345762-khvcoqti	6	10	virus	virus	NN
cord-345762-khvcoqti	6	11	,	,	,
cord-345762-khvcoqti	6	12	such	such	JJ
cord-345762-khvcoqti	6	13	as	as	IN
cord-345762-khvcoqti	6	14	COVID-19	COVID-19	NNP
cord-345762-khvcoqti	6	15	,	,	,
cord-345762-khvcoqti	6	16	generate	generate	VBP
cord-345762-khvcoqti	6	17	a	a	DT
cord-345762-khvcoqti	6	18	giant	giant	JJ
cord-345762-khvcoqti	6	19	thirst	thirst	NN
cord-345762-khvcoqti	6	20	for	for	IN
cord-345762-khvcoqti	6	21	instant	instant	JJ
cord-345762-khvcoqti	6	22	knowledge	knowledge	NN
cord-345762-khvcoqti	6	23	in	in	IN
cord-345762-khvcoqti	6	24	how	how	WRB
cord-345762-khvcoqti	6	25	to	to	TO
cord-345762-khvcoqti	6	26	treat	treat	VB
cord-345762-khvcoqti	6	27	the	the	DT
cord-345762-khvcoqti	6	28	disease	disease	NN
cord-345762-khvcoqti	6	29	.	.	.
cord-345762-khvcoqti	7	1	The	the	DT
cord-345762-khvcoqti	7	2	imperative	imperative	NN
cord-345762-khvcoqti	7	3	becomes	become	VBZ
cord-345762-khvcoqti	7	4	doing	do	VBG
cord-345762-khvcoqti	7	5	something	something	NN
cord-345762-khvcoqti	7	6	,	,	,
cord-345762-khvcoqti	7	7	anything	anything	NN
cord-345762-khvcoqti	7	8	,	,	,
cord-345762-khvcoqti	7	9	that	that	IN
cord-345762-khvcoqti	7	10	we	-PRON-	PRP
cord-345762-khvcoqti	7	11	think	think	VBP
cord-345762-khvcoqti	7	12	may	may	MD
cord-345762-khvcoqti	7	13	help	help	VB
cord-345762-khvcoqti	7	14	.	.	.
cord-345762-khvcoqti	8	1	This	this	DT
cord-345762-khvcoqti	8	2	creates	create	VBZ
cord-345762-khvcoqti	8	3	tension	tension	NN
cord-345762-khvcoqti	8	4	between	between	IN
cord-345762-khvcoqti	8	5	exploiting	exploit	VBG
cord-345762-khvcoqti	8	6	whatever	whatever	WDT
cord-345762-khvcoqti	8	7	actionable	actionable	JJ
cord-345762-khvcoqti	8	8	clues	clue	NNS
cord-345762-khvcoqti	8	9	we	-PRON-	PRP
cord-345762-khvcoqti	8	10	can	can	MD
cord-345762-khvcoqti	8	11	gleam	gleam	VB
cord-345762-khvcoqti	8	12	from	from	IN
cord-345762-khvcoqti	8	13	observations	observation	NNS
cord-345762-khvcoqti	8	14	and	and	CC
cord-345762-khvcoqti	8	15	anecdotes	anecdote	NNS
cord-345762-khvcoqti	8	16	versus	versus	IN
cord-345762-khvcoqti	8	17	conducting	conduct	VBG
cord-345762-khvcoqti	8	18	proper	proper	JJ
cord-345762-khvcoqti	8	19	clinical	clinical	JJ
cord-345762-khvcoqti	8	20	trialsthe	trialsthe	DT
cord-345762-khvcoqti	8	21	quick	quick	JJ
cord-345762-khvcoqti	8	22	and	and	CC
cord-345762-khvcoqti	8	23	dirty	dirty	JJ
cord-345762-khvcoqti	8	24	versus	versus	IN
cord-345762-khvcoqti	8	25	the	the	DT
cord-345762-khvcoqti	8	26	slow	slow	JJ
cord-345762-khvcoqti	8	27	and	and	CC
cord-345762-khvcoqti	8	28	rigorous	rigorous	JJ
cord-345762-khvcoqti	8	29	.	.	.
cord-345762-khvcoqti	9	1	Can	Can	MD
cord-345762-khvcoqti	9	2	we	-PRON-	PRP
cord-345762-khvcoqti	9	3	increase	increase	VB
cord-345762-khvcoqti	9	4	the	the	DT
cord-345762-khvcoqti	9	5	tempo	tempo	NN
cord-345762-khvcoqti	9	6	of	of	IN
cord-345762-khvcoqti	9	7	discovery	discovery	NN
cord-345762-khvcoqti	9	8	while	while	IN
cord-345762-khvcoqti	9	9	staying	stay	VBG
cord-345762-khvcoqti	9	10	faithful	faithful	JJ
cord-345762-khvcoqti	9	11	to	to	IN
cord-345762-khvcoqti	9	12	scientific	scientific	JJ
cord-345762-khvcoqti	9	13	method	method	NN
cord-345762-khvcoqti	9	14	?	?	.
cord-345762-khvcoqti	10	1	In	in	IN
cord-345762-khvcoqti	10	2	identifying	identify	VBG
cord-345762-khvcoqti	10	3	effective	effective	JJ
cord-345762-khvcoqti	10	4	therapies	therapy	NNS
cord-345762-khvcoqti	10	5	,	,	,
cord-345762-khvcoqti	10	6	there	there	EX
cord-345762-khvcoqti	10	7	are	be	VBP
cord-345762-khvcoqti	10	8	already	already	RB
cord-345762-khvcoqti	10	9	hundreds	hundred	NNS
cord-345762-khvcoqti	10	10	of	of	IN
cord-345762-khvcoqti	10	11	COVID-19	COVID-19	NNP
cord-345762-khvcoqti	10	12	trials	trial	NNS
cord-345762-khvcoqti	10	13	registered	register	VBN
cord-345762-khvcoqti	10	14	worldwide	worldwide	RB
cord-345762-khvcoqti	10	15	,	,	,
cord-345762-khvcoqti	10	16	with	with	IN
cord-345762-khvcoqti	10	17	numbers	number	NNS
cord-345762-khvcoqti	10	18	increasing	increase	VBG
cord-345762-khvcoqti	10	19	daily	daily	RB
cord-345762-khvcoqti	10	20	.	.	.
cord-345762-khvcoqti	11	1	1	1	LS
cord-345762-khvcoqti	12	1	This	this	DT
cord-345762-khvcoqti	12	2	is	be	VBZ
cord-345762-khvcoqti	12	3	a	a	DT
cord-345762-khvcoqti	12	4	positivethe	positivethe	JJ
cord-345762-khvcoqti	12	5	rapid	rapid	JJ
cord-345762-khvcoqti	12	6	mobilisation	mobilisation	NN
cord-345762-khvcoqti	12	7	of	of	IN
cord-345762-khvcoqti	12	8	trialists	trialist	NNS
cord-345762-khvcoqti	12	9	around	around	IN
cord-345762-khvcoqti	12	10	the	the	DT
cord-345762-khvcoqti	12	11	world	world	NN
cord-345762-khvcoqti	12	12	,	,	,
cord-345762-khvcoqti	12	13	many	many	JJ
cord-345762-khvcoqti	12	14	suspending	suspend	VBG
cord-345762-khvcoqti	12	15	their	-PRON-	PRP$
cord-345762-khvcoqti	12	16	prior	prior	JJ
cord-345762-khvcoqti	12	17	research	research	NN
cord-345762-khvcoqti	12	18	programmes	programme	NNS
cord-345762-khvcoqti	12	19	to	to	TO
cord-345762-khvcoqti	12	20	focus	focus	VB
cord-345762-khvcoqti	12	21	on	on	IN
cord-345762-khvcoqti	12	22	COVID-19	COVID-19	NNP
cord-345762-khvcoqti	12	23	and	and	CC
cord-345762-khvcoqti	12	24	enlisting	enlist	VBG
cord-345762-khvcoqti	12	25	the	the	DT
cord-345762-khvcoqti	12	26	support	support	NN
cord-345762-khvcoqti	12	27	of	of	IN
cord-345762-khvcoqti	12	28	multiple	multiple	JJ
cord-345762-khvcoqti	12	29	funders	funder	NNS
cord-345762-khvcoqti	12	30	.	.	.
cord-345762-khvcoqti	13	1	But	but	CC
cord-345762-khvcoqti	13	2	with	with	IN
cord-345762-khvcoqti	13	3	so	so	RB
cord-345762-khvcoqti	13	4	many	many	JJ
cord-345762-khvcoqti	13	5	different	different	JJ
cord-345762-khvcoqti	13	6	trials	trial	NNS
cord-345762-khvcoqti	13	7	,	,	,
cord-345762-khvcoqti	13	8	there	there	EX
cord-345762-khvcoqti	13	9	is	be	VBZ
cord-345762-khvcoqti	13	10	also	also	RB
cord-345762-khvcoqti	13	11	the	the	DT
cord-345762-khvcoqti	13	12	potential	potential	NN
cord-345762-khvcoqti	13	13	for	for	IN
cord-345762-khvcoqti	13	14	wasteful	wasteful	JJ
cord-345762-khvcoqti	13	15	duplication	duplication	NN
cord-345762-khvcoqti	13	16	,	,	,
cord-345762-khvcoqti	13	17	competition	competition	NN
cord-345762-khvcoqti	13	18	for	for	IN
cord-345762-khvcoqti	13	19	limited	limited	JJ
cord-345762-khvcoqti	13	20	resources	resource	NNS
cord-345762-khvcoqti	13	21	,	,	,
cord-345762-khvcoqti	13	22	including	include	VBG
cord-345762-khvcoqti	13	23	recruitable	recruitable	JJ
cord-345762-khvcoqti	13	24	patients	patient	NNS
cord-345762-khvcoqti	13	25	,	,	,
cord-345762-khvcoqti	13	26	and	and	CC
cord-345762-khvcoqti	13	27	reporting	reporting	NN
cord-345762-khvcoqti	13	28	of	of	IN
cord-345762-khvcoqti	13	29	poorly	poorly	RB
cord-345762-khvcoqti	13	30	designed	design	VBN
cord-345762-khvcoqti	13	31	and	and	CC
cord-345762-khvcoqti	13	32	underpowered	underpowered	JJ
cord-345762-khvcoqti	13	33	studies	study	NNS
cord-345762-khvcoqti	13	34	that	that	WDT
cord-345762-khvcoqti	13	35	result	result	VBP
cord-345762-khvcoqti	13	36	in	in	IN
cord-345762-khvcoqti	13	37	premature	premature	JJ
cord-345762-khvcoqti	13	38	rejection	rejection	NN
cord-345762-khvcoqti	13	39	of	of	IN
cord-345762-khvcoqti	13	40	promising	promising	JJ
cord-345762-khvcoqti	13	41	drugs	drug	NNS
cord-345762-khvcoqti	13	42	or	or	CC
cord-345762-khvcoqti	13	43	premature	premature	JJ
cord-345762-khvcoqti	13	44	adoption	adoption	NN
cord-345762-khvcoqti	13	45	of	of	IN
cord-345762-khvcoqti	13	46	ineffective	ineffective	JJ
cord-345762-khvcoqti	13	47	ones	one	NNS
cord-345762-khvcoqti	13	48	as	as	IN
cord-345762-khvcoqti	13	49	standards	standard	NNS
cord-345762-khvcoqti	13	50	of	of	IN
cord-345762-khvcoqti	13	51	care	care	NN
cord-345762-khvcoqti	13	52	.	.	.
cord-345762-khvcoqti	14	1	The	the	DT
cord-345762-khvcoqti	14	2	false	false	JJ
cord-345762-khvcoqti	14	3	promise	promise	NN
cord-345762-khvcoqti	14	4	of	of	IN
cord-345762-khvcoqti	14	5	rushed	rush	VBN
cord-345762-khvcoqti	14	6	science	science	NN
cord-345762-khvcoqti	14	7	A	a	DT
cord-345762-khvcoqti	14	8	pandemic	pandemic	NN
cord-345762-khvcoqti	14	9	as	as	RB
cord-345762-khvcoqti	14	10	serious	serious	JJ
cord-345762-khvcoqti	14	11	as	as	IN
cord-345762-khvcoqti	14	12	COVID-19	COVID-19	NNP
cord-345762-khvcoqti	14	13	will	will	MD
cord-345762-khvcoqti	14	14	compel	compel	VB
cord-345762-khvcoqti	14	15	some	some	DT
cord-345762-khvcoqti	14	16	clinicians	clinician	NNS
cord-345762-khvcoqti	14	17	and	and	CC
cord-345762-khvcoqti	14	18	patients	patient	NNS
cord-345762-khvcoqti	14	19	to	to	TO
cord-345762-khvcoqti	14	20	try	try	VB
cord-345762-khvcoqti	14	21	unproven	unproven	JJ
cord-345762-khvcoqti	14	22	therapies	therapy	NNS
cord-345762-khvcoqti	14	23	based	base	VBN
cord-345762-khvcoqti	14	24	on	on	IN
cord-345762-khvcoqti	14	25	theory	theory	NN
cord-345762-khvcoqti	14	26	,	,	,
cord-345762-khvcoqti	14	27	in	in	IN
cord-345762-khvcoqti	14	28	vitro	vitro	FW
cord-345762-khvcoqti	14	29	data	datum	NNS
cord-345762-khvcoqti	14	30	,	,	,
cord-345762-khvcoqti	14	31	animal	animal	NN
cord-345762-khvcoqti	14	32	models	model	NNS
cord-345762-khvcoqti	14	33	,	,	,
cord-345762-khvcoqti	14	34	clinical	clinical	JJ
cord-345762-khvcoqti	14	35	anecdotes	anecdote	NNS
cord-345762-khvcoqti	14	36	,	,	,
cord-345762-khvcoqti	14	37	observational	observational	JJ
cord-345762-khvcoqti	14	38	studies	study	NNS
cord-345762-khvcoqti	14	39	and	and	CC
cord-345762-khvcoqti	14	40	uncontrolled	uncontrolled	JJ
cord-345762-khvcoqti	14	41	trials	trial	NNS
cord-345762-khvcoqti	14	42	that	that	WDT
cord-345762-khvcoqti	14	43	may	may	MD
cord-345762-khvcoqti	14	44	later	later	RB
cord-345762-khvcoqti	14	45	be	be	VB
cord-345762-khvcoqti	14	46	shown	show	VBN
cord-345762-khvcoqti	14	47	to	to	TO
cord-345762-khvcoqti	14	48	be	be	VB
cord-345762-khvcoqti	14	49	misleading	misleading	JJ
cord-345762-khvcoqti	14	50	.	.	.
cord-345762-khvcoqti	15	1	2	2	LS
cord-345762-khvcoqti	16	1	This	this	DT
cord-345762-khvcoqti	16	2	was	be	VBD
cord-345762-khvcoqti	16	3	the	the	DT
cord-345762-khvcoqti	16	4	case	case	NN
cord-345762-khvcoqti	16	5	during	during	IN
cord-345762-khvcoqti	16	6	the	the	DT
cord-345762-khvcoqti	16	7	novel	novel	JJ
cord-345762-khvcoqti	16	8	influenza	influenza	NN
cord-345762-khvcoqti	16	9	A	a	NN
cord-345762-khvcoqti	16	10	(	(	-LRB-
cord-345762-khvcoqti	16	11	H1N1	H1N1	NNP
cord-345762-khvcoqti	16	12	)	)	-RRB-
cord-345762-khvcoqti	16	13	viral	viral	JJ
cord-345762-khvcoqti	16	14	pandemic	pandemic	NN
cord-345762-khvcoqti	16	15	in	in	IN
cord-345762-khvcoqti	16	16	2009	2009	CD
cord-345762-khvcoqti	16	17	,	,	,
cord-345762-khvcoqti	16	18	when	when	WRB
cord-345762-khvcoqti	16	19	low	low	JJ
cord-345762-khvcoqti	16	20	-	-	HYPH
cord-345762-khvcoqti	16	21	quality	quality	NN
cord-345762-khvcoqti	16	22	and	and	CC
cord-345762-khvcoqti	16	23	incomplete	incomplete	JJ
cord-345762-khvcoqti	16	24	data	datum	NNS
cord-345762-khvcoqti	16	25	suggested	suggest	VBD
cord-345762-khvcoqti	16	26	oseltamivir	oseltamivir	NNP
cord-345762-khvcoqti	16	27	was	be	VBD
cord-345762-khvcoqti	16	28	potentially	potentially	RB
cord-345762-khvcoqti	16	29	beneficial	beneficial	JJ
cord-345762-khvcoqti	16	30	in	in	IN
cord-345762-khvcoqti	16	31	preventing	prevent	VBG
cord-345762-khvcoqti	16	32	complications	complication	NNS
cord-345762-khvcoqti	16	33	and	and	CC
cord-345762-khvcoqti	16	34	deaths	death	NNS
cord-345762-khvcoqti	16	35	among	among	IN
cord-345762-khvcoqti	16	36	patients	patient	NNS
cord-345762-khvcoqti	16	37	hospitalised	hospitalise	VBN
cord-345762-khvcoqti	16	38	with	with	IN
cord-345762-khvcoqti	16	39	influenza	influenza	NN
cord-345762-khvcoqti	16	40	.	.	.
cord-345762-khvcoqti	17	1	3	3	LS
cord-345762-khvcoqti	18	1	As	as	IN
cord-345762-khvcoqti	18	2	a	a	DT
cord-345762-khvcoqti	18	3	result	result	NN
cord-345762-khvcoqti	18	4	,	,	,
cord-345762-khvcoqti	18	5	countries	country	NNS
cord-345762-khvcoqti	18	6	stockpiled	stockpile	VBN
cord-345762-khvcoqti	18	7	and	and	CC
cord-345762-khvcoqti	18	8	used	use	VBD
cord-345762-khvcoqti	18	9	the	the	DT
cord-345762-khvcoqti	18	10	drug	drug	NN
cord-345762-khvcoqti	18	11	extensively	extensively	RB
cord-345762-khvcoqti	18	12	and	and	CC
cord-345762-khvcoqti	18	13	at	at	IN
cord-345762-khvcoqti	18	14	great	great	JJ
cord-345762-khvcoqti	18	15	expense	expense	NN
cord-345762-khvcoqti	18	16	,	,	,
cord-345762-khvcoqti	18	17	but	but	CC
cord-345762-khvcoqti	18	18	to	to	IN
cord-345762-khvcoqti	18	19	this	this	DT
cord-345762-khvcoqti	18	20	day	day	NN
cord-345762-khvcoqti	18	21	,	,	,
cord-345762-khvcoqti	18	22	there	there	EX
cord-345762-khvcoqti	18	23	has	have	VBZ
cord-345762-khvcoqti	18	24	been	be	VBN
cord-345762-khvcoqti	18	25	no	no	DT
cord-345762-khvcoqti	18	26	high	high	JJ
cord-345762-khvcoqti	18	27	-	-	HYPH
cord-345762-khvcoqti	18	28	quality	quality	NN
cord-345762-khvcoqti	18	29	randomised	randomised	JJ
cord-345762-khvcoqti	18	30	controlled	control	VBN
cord-345762-khvcoqti	18	31	trial	trial	NN
cord-345762-khvcoqti	18	32	(	(	-LRB-
cord-345762-khvcoqti	18	33	RCT	RCT	NNP
cord-345762-khvcoqti	18	34	)	)	-RRB-
cord-345762-khvcoqti	18	35	to	to	TO
cord-345762-khvcoqti	18	36	confirm	confirm	VB
cord-345762-khvcoqti	18	37	definitively	definitively	RB
cord-345762-khvcoqti	18	38	the	the	DT
cord-345762-khvcoqti	18	39	efficacy	efficacy	NN
cord-345762-khvcoqti	18	40	of	of	IN
cord-345762-khvcoqti	18	41	oseltamivir	oseltamivir	NNP
cord-345762-khvcoqti	18	42	.	.	.
cord-345762-khvcoqti	19	1	Numerous	numerous	JJ
cord-345762-khvcoqti	19	2	studies	study	NNS
cord-345762-khvcoqti	19	3	have	have	VBP
cord-345762-khvcoqti	19	4	already	already	RB
cord-345762-khvcoqti	19	5	been	be	VBN
cord-345762-khvcoqti	19	6	reported	report	VBN
cord-345762-khvcoqti	19	7	during	during	IN
cord-345762-khvcoqti	19	8	the	the	DT
cord-345762-khvcoqti	19	9	current	current	JJ
cord-345762-khvcoqti	19	10	pandemic	pandemic	NN
cord-345762-khvcoqti	19	11	,	,	,
cord-345762-khvcoqti	19	12	many	many	JJ
cord-345762-khvcoqti	19	13	as	as	IN
cord-345762-khvcoqti	19	14	pre	pre	NNS
cord-345762-khvcoqti	19	15	-	-	NNS
cord-345762-khvcoqti	19	16	prints	print	NNS
cord-345762-khvcoqti	19	17	,	,	,
cord-345762-khvcoqti	19	18	in	in	IN
cord-345762-khvcoqti	19	19	an	an	DT
cord-345762-khvcoqti	19	20	effort	effort	NN
cord-345762-khvcoqti	19	21	to	to	TO
cord-345762-khvcoqti	19	22	disseminate	disseminate	VB
cord-345762-khvcoqti	19	23	results	result	NNS
cord-345762-khvcoqti	19	24	quickly	quickly	RB
cord-345762-khvcoqti	19	25	,	,	,
cord-345762-khvcoqti	19	26	but	but	CC
cord-345762-khvcoqti	19	27	which	which	WDT
cord-345762-khvcoqti	19	28	are	be	VBP
cord-345762-khvcoqti	19	29	yet	yet	RB
cord-345762-khvcoqti	19	30	to	to	TO
cord-345762-khvcoqti	19	31	undergo	undergo	VB
cord-345762-khvcoqti	19	32	peer	peer	NN
cord-345762-khvcoqti	19	33	review	review	NN
cord-345762-khvcoqti	19	34	.	.	.
cord-345762-khvcoqti	20	1	Others	other	NNS
cord-345762-khvcoqti	20	2	have	have	VBP
cord-345762-khvcoqti	20	3	undergone	undergo	VBN
cord-345762-khvcoqti	20	4	fast	fast	JJ
cord-345762-khvcoqti	20	5	-	-	HYPH
cord-345762-khvcoqti	20	6	track	track	NN
cord-345762-khvcoqti	20	7	review	review	NN
cord-345762-khvcoqti	20	8	,	,	,
cord-345762-khvcoqti	20	9	which	which	WDT
cord-345762-khvcoqti	20	10	may	may	MD
cord-345762-khvcoqti	20	11	be	be	VB
cord-345762-khvcoqti	20	12	less	less	RBR
cord-345762-khvcoqti	20	13	stringent	stringent	JJ
cord-345762-khvcoqti	20	14	or	or	CC
cord-345762-khvcoqti	20	15	probing	probing	JJ
cord-345762-khvcoqti	20	16	than	than	IN
cord-345762-khvcoqti	20	17	the	the	DT
cord-345762-khvcoqti	20	18	usual	usual	JJ
cord-345762-khvcoqti	20	19	process	process	NN
cord-345762-khvcoqti	20	20	,	,	,
cord-345762-khvcoqti	20	21	which	which	WDT
cord-345762-khvcoqti	20	22	can	can	MD
cord-345762-khvcoqti	20	23	take	take	VB
cord-345762-khvcoqti	20	24	many	many	JJ
cord-345762-khvcoqti	20	25	weeks	week	NNS
cord-345762-khvcoqti	20	26	.	.	.
cord-345762-khvcoqti	21	1	Studies	study	NNS
cord-345762-khvcoqti	21	2	reporting	report	VBG
cord-345762-khvcoqti	21	3	promising	promising	JJ
cord-345762-khvcoqti	21	4	results	result	NNS
cord-345762-khvcoqti	21	5	have	have	VBP
cord-345762-khvcoqti	21	6	featured	feature	VBN
cord-345762-khvcoqti	21	7	cohort	cohort	NN
cord-345762-khvcoqti	21	8	studies	study	NNS
cord-345762-khvcoqti	21	9	,	,	,
cord-345762-khvcoqti	21	10	4	4	CD
cord-345762-khvcoqti	21	11	case	case	NN
cord-345762-khvcoqti	21	12	series	series	NN
cord-345762-khvcoqti	21	13	5	5	CD
cord-345762-khvcoqti	21	14	and	and	CC
cord-345762-khvcoqti	21	15	even	even	RB
cord-345762-khvcoqti	21	16	single	single	JJ
cord-345762-khvcoqti	21	17	case	case	NN
cord-345762-khvcoqti	21	18	reports	report	VBZ
cord-345762-khvcoqti	21	19	6	6	CD
cord-345762-khvcoqti	21	20	that	that	IN
cord-345762-khvcoqti	21	21	,	,	,
cord-345762-khvcoqti	21	22	at	at	IN
cord-345762-khvcoqti	21	23	any	any	DT
cord-345762-khvcoqti	21	24	other	other	JJ
cord-345762-khvcoqti	21	25	time	time	NN
cord-345762-khvcoqti	21	26	,	,	,
cord-345762-khvcoqti	21	27	would	would	MD
cord-345762-khvcoqti	21	28	have	have	VB
cord-345762-khvcoqti	21	29	been	be	VBN
cord-345762-khvcoqti	21	30	regarded	regard	VBN
cord-345762-khvcoqti	21	31	as	as	IN
cord-345762-khvcoqti	21	32	no	no	DT
cord-345762-khvcoqti	21	33	more	more	JJR
cord-345762-khvcoqti	21	34	than	than	IN
cord-345762-khvcoqti	21	35	hypothesis	hypothesis	NN
cord-345762-khvcoqti	21	36	-	-	HYPH
cord-345762-khvcoqti	21	37	generating	generate	VBG
cord-345762-khvcoqti	21	38	on	on	IN
cord-345762-khvcoqti	21	39	account	account	NN
cord-345762-khvcoqti	21	40	of	of	IN
cord-345762-khvcoqti	21	41	their	-PRON-	PRP$
cord-345762-khvcoqti	21	42	high	high	JJ
cord-345762-khvcoqti	21	43	risk	risk	NN
cord-345762-khvcoqti	21	44	of	of	IN
cord-345762-khvcoqti	21	45	bias	bias	NN
cord-345762-khvcoqti	21	46	due	due	IN
cord-345762-khvcoqti	21	47	to	to	IN
cord-345762-khvcoqti	21	48	their	-PRON-	PRP$
cord-345762-khvcoqti	21	49	observational	observational	JJ
cord-345762-khvcoqti	21	50	design	design	NN
cord-345762-khvcoqti	21	51	.	.	.
cord-345762-khvcoqti	22	1	Instead	instead	RB
cord-345762-khvcoqti	22	2	,	,	,
cord-345762-khvcoqti	22	3	some	some	DT
cord-345762-khvcoqti	22	4	now	now	RB
cord-345762-khvcoqti	22	5	receive	receive	VBP
cord-345762-khvcoqti	22	6	considerable	considerable	JJ
cord-345762-khvcoqti	22	7	publicity	publicity	NN
cord-345762-khvcoqti	22	8	as	as	IN
cord-345762-khvcoqti	22	9	'	'	``
cord-345762-khvcoqti	22	10	treatments	treatment	NNS
cord-345762-khvcoqti	22	11	'	'	''
cord-345762-khvcoqti	22	12	from	from	IN
cord-345762-khvcoqti	22	13	media	medium	NNS
cord-345762-khvcoqti	22	14	outlets	outlet	NNS
cord-345762-khvcoqti	22	15	,	,	,
cord-345762-khvcoqti	22	16	helped	help	VBD
cord-345762-khvcoqti	22	17	along	along	RP
cord-345762-khvcoqti	22	18	in	in	IN
cord-345762-khvcoqti	22	19	some	some	DT
cord-345762-khvcoqti	22	20	instances	instance	NNS
cord-345762-khvcoqti	22	21	by	by	IN
cord-345762-khvcoqti	22	22	endorsement	endorsement	NN
cord-345762-khvcoqti	22	23	as	as	IN
cord-345762-khvcoqti	22	24	'	'	``
cord-345762-khvcoqti	22	25	game	game	NN
cord-345762-khvcoqti	22	26	changers	changer	NNS
cord-345762-khvcoqti	22	27	'	'	''
cord-345762-khvcoqti	22	28	by	by	IN
cord-345762-khvcoqti	22	29	high	high	JJ
cord-345762-khvcoqti	22	30	-	-	HYPH
cord-345762-khvcoqti	22	31	profile	profile	NN
cord-345762-khvcoqti	22	32	celebrities	celebrity	NNS
cord-345762-khvcoqti	22	33	and	and	CC
cord-345762-khvcoqti	22	34	politicians	politician	NNS
cord-345762-khvcoqti	22	35	.	.	.
cord-345762-khvcoqti	23	1	7	7	CD
cord-345762-khvcoqti	23	2	Medications	medication	NNS
cord-345762-khvcoqti	23	3	lacking	lack	VBG
cord-345762-khvcoqti	23	4	any	any	DT
cord-345762-khvcoqti	23	5	approval	approval	NN
cord-345762-khvcoqti	23	6	for	for	IN
cord-345762-khvcoqti	23	7	any	any	DT
cord-345762-khvcoqti	23	8	indication	indication	NN
cord-345762-khvcoqti	23	9	are	be	VBP
cord-345762-khvcoqti	23	10	also	also	RB
cord-345762-khvcoqti	23	11	being	be	VBG
cord-345762-khvcoqti	23	12	widely	widely	RB
cord-345762-khvcoqti	23	13	used	use	VBN
cord-345762-khvcoqti	23	14	outside	outside	RB
cord-345762-khvcoqti	23	15	of	of	IN
cord-345762-khvcoqti	23	16	clinical	clinical	JJ
cord-345762-khvcoqti	23	17	trial	trial	NN
cord-345762-khvcoqti	23	18	protocols	protocol	NNS
cord-345762-khvcoqti	23	19	.	.	.
cord-345762-khvcoqti	24	1	8	8	CD
cord-345762-khvcoqti	24	2	Unproven	unproven	JJ
cord-345762-khvcoqti	24	3	therapies	therapy	NNS
cord-345762-khvcoqti	24	4	have	have	VBP
cord-345762-khvcoqti	24	5	become	become	VBN
cord-345762-khvcoqti	24	6	accepted	accept	VBN
cord-345762-khvcoqti	24	7	as	as	IN
cord-345762-khvcoqti	24	8	new	new	JJ
cord-345762-khvcoqti	24	9	standards	standard	NNS
cord-345762-khvcoqti	24	10	of	of	IN
cord-345762-khvcoqti	24	11	care	care	NN
cord-345762-khvcoqti	24	12	,	,	,
cord-345762-khvcoqti	24	13	thus	thus	RB
cord-345762-khvcoqti	24	14	extinguishing	extinguish	VBG
cord-345762-khvcoqti	24	15	the	the	DT
cord-345762-khvcoqti	24	16	equipoise	equipoise	NN
cord-345762-khvcoqti	24	17	needed	need	VBN
cord-345762-khvcoqti	24	18	to	to	TO
cord-345762-khvcoqti	24	19	undertake	undertake	VB
cord-345762-khvcoqti	24	20	RCT	RCT	NNP
cord-345762-khvcoqti	24	21	.	.	.
cord-345762-khvcoqti	25	1	As	as	IN
cord-345762-khvcoqti	25	2	an	an	DT
cord-345762-khvcoqti	25	3	example	example	NN
cord-345762-khvcoqti	25	4	,	,	,
cord-345762-khvcoqti	25	5	concerned	concern	VBN
cord-345762-khvcoqti	25	6	by	by	IN
cord-345762-khvcoqti	25	7	reports	report	NNS
cord-345762-khvcoqti	25	8	of	of	IN
cord-345762-khvcoqti	25	9	increased	increase	VBN
cord-345762-khvcoqti	25	10	incidence	incidence	NN
cord-345762-khvcoqti	25	11	of	of	IN
cord-345762-khvcoqti	25	12	thrombosis	thrombosis	NN
cord-345762-khvcoqti	25	13	and	and	CC
cord-345762-khvcoqti	25	14	disseminated	disseminate	VBN
cord-345762-khvcoqti	25	15	intravascular	intravascular	JJ
cord-345762-khvcoqti	25	16	coagulation	coagulation	NN
cord-345762-khvcoqti	25	17	in	in	IN
cord-345762-khvcoqti	25	18	seriously	seriously	RB
cord-345762-khvcoqti	25	19	ill	ill	JJ
cord-345762-khvcoqti	26	1	COVID-19	covid-19	JJ
cord-345762-khvcoqti	26	2	patients	patient	NNS
cord-345762-khvcoqti	26	3	,	,	,
cord-345762-khvcoqti	26	4	9,10	9,10	CD
cord-345762-khvcoqti	27	1	the	the	DT
cord-345762-khvcoqti	27	2	results	result	NNS
cord-345762-khvcoqti	27	3	of	of	IN
cord-345762-khvcoqti	27	4	a	a	DT
cord-345762-khvcoqti	27	5	very	very	RB
cord-345762-khvcoqti	27	6	low	low	JJ
cord-345762-khvcoqti	27	7	-	-	HYPH
cord-345762-khvcoqti	27	8	quality	quality	NN
cord-345762-khvcoqti	27	9	observational	observational	JJ
cord-345762-khvcoqti	27	10	study	study	NN
cord-345762-khvcoqti	27	11	of	of	IN
cord-345762-khvcoqti	27	12	the	the	DT
cord-345762-khvcoqti	27	13	use	use	NN
cord-345762-khvcoqti	27	14	of	of	IN
cord-345762-khvcoqti	27	15	anticoagulants	anticoagulant	NNS
cord-345762-khvcoqti	27	16	(	(	-LRB-
cord-345762-khvcoqti	27	17	AC	ac	NN
cord-345762-khvcoqti	27	18	)	)	-RRB-
cord-345762-khvcoqti	28	1	11,12	11,12	CD
cord-345762-khvcoqti	28	2	led	lead	VBD
cord-345762-khvcoqti	28	3	one	one	CD
cord-345762-khvcoqti	28	4	US	US	NNP
cord-345762-khvcoqti	28	5	hospital	hospital	NN
cord-345762-khvcoqti	28	6	system	system	NN
cord-345762-khvcoqti	28	7	to	to	TO
cord-345762-khvcoqti	28	8	protocolise	protocolise	VB
cord-345762-khvcoqti	28	9	the	the	DT
cord-345762-khvcoqti	28	10	use	use	NN
cord-345762-khvcoqti	28	11	of	of	IN
cord-345762-khvcoqti	28	12	highdose	highdose	NN
cord-345762-khvcoqti	28	13	AC	ac	NN
cord-345762-khvcoqti	28	14	in	in	IN
cord-345762-khvcoqti	28	15	patients	patient	NNS
cord-345762-khvcoqti	28	16	with	with	IN
cord-345762-khvcoqti	28	17	COVID-19	COVID-19	NNP
cord-345762-khvcoqti	28	18	admitted	admit	VBN
cord-345762-khvcoqti	28	19	to	to	IN
cord-345762-khvcoqti	28	20	intensive	intensive	JJ
cord-345762-khvcoqti	28	21	care	care	NN
cord-345762-khvcoqti	28	22	(	(	-LRB-
cord-345762-khvcoqti	28	23	Box	Box	NNP
cord-345762-khvcoqti	28	24	1	1	CD
cord-345762-khvcoqti	28	25	)	)	-RRB-
cord-345762-khvcoqti	28	26	.	.	.
cord-345762-khvcoqti	29	1	While	while	IN
cord-345762-khvcoqti	29	2	more	more	RBR
cord-345762-khvcoqti	29	3	rigorous	rigorous	JJ
cord-345762-khvcoqti	29	4	propensity	propensity	NN
cord-345762-khvcoqti	29	5	-	-	HYPH
cord-345762-khvcoqti	29	6	matched	match	VBN
cord-345762-khvcoqti	29	7	observational	observational	JJ
cord-345762-khvcoqti	29	8	studies	study	NNS
cord-345762-khvcoqti	29	9	comparing	compare	VBG
cord-345762-khvcoqti	29	10	one	one	CD
cord-345762-khvcoqti	29	11	treatment	treatment	NN
cord-345762-khvcoqti	29	12	group	group	NN
cord-345762-khvcoqti	29	13	to	to	IN
cord-345762-khvcoqti	29	14	another	another	DT
cord-345762-khvcoqti	29	15	lend	lend	VB
cord-345762-khvcoqti	29	16	useful	useful	JJ
cord-345762-khvcoqti	29	17	insights	insight	NNS
cord-345762-khvcoqti	29	18	,	,	,
cord-345762-khvcoqti	29	19	13	13	CD
cord-345762-khvcoqti	29	20	the	the	DT
cord-345762-khvcoqti	29	21	best	good	JJS
cord-345762-khvcoqti	29	22	adjustment	adjustment	NN
cord-345762-khvcoqti	29	23	methods	method	NNS
cord-345762-khvcoqti	29	24	can	can	MD
cord-345762-khvcoqti	29	25	still	still	RB
cord-345762-khvcoqti	29	26	miss	miss	VB
cord-345762-khvcoqti	29	27	major	major	JJ
cord-345762-khvcoqti	29	28	systematic	systematic	JJ
cord-345762-khvcoqti	29	29	biases	bias	NNS
cord-345762-khvcoqti	29	30	,	,	,
cord-345762-khvcoqti	29	31	especially	especially	RB
cord-345762-khvcoqti	29	32	when	when	WRB
cord-345762-khvcoqti	29	33	responding	respond	VBG
cord-345762-khvcoqti	29	34	to	to	IN
cord-345762-khvcoqti	29	35	a	a	DT
cord-345762-khvcoqti	29	36	rapidly	rapidly	RB
cord-345762-khvcoqti	29	37	spreading	spread	VBG
cord-345762-khvcoqti	29	38	and	and	CC
cord-345762-khvcoqti	29	39	deadly	deadly	JJ
cord-345762-khvcoqti	29	40	pandemic	pandemic	NN
cord-345762-khvcoqti	29	41	.	.	.
cord-345762-khvcoqti	30	1	In	in	IN
cord-345762-khvcoqti	30	2	extreme	extreme	JJ
cord-345762-khvcoqti	30	3	times	time	NNS
cord-345762-khvcoqti	30	4	,	,	,
cord-345762-khvcoqti	30	5	RCT	RCT	NNP
cord-345762-khvcoqti	30	6	too	too	RB
cord-345762-khvcoqti	30	7	have	have	VBP
cord-345762-khvcoqti	30	8	been	be	VBN
cord-345762-khvcoqti	30	9	flawed	flaw	VBN
cord-345762-khvcoqti	30	10	by	by	IN
cord-345762-khvcoqti	30	11	illspecified	illspecifie	VBN
cord-345762-khvcoqti	30	12	inclusion	inclusion	NN
cord-345762-khvcoqti	30	13	criteria	criterion	NNS
cord-345762-khvcoqti	30	14	,	,	,
cord-345762-khvcoqti	30	15	convenience	convenience	NN
cord-345762-khvcoqti	30	16	sampling	sampling	NN
cord-345762-khvcoqti	30	17	,	,	,
cord-345762-khvcoqti	30	18	small	small	JJ
cord-345762-khvcoqti	30	19	samples	sample	NNS
cord-345762-khvcoqti	30	20	from	from	IN
cord-345762-khvcoqti	30	21	single	single	JJ
cord-345762-khvcoqti	30	22	centres	centre	NNS
cord-345762-khvcoqti	30	23	with	with	IN
cord-345762-khvcoqti	30	24	inadequate	inadequate	JJ
cord-345762-khvcoqti	30	25	power	power	NN
cord-345762-khvcoqti	30	26	,	,	,
cord-345762-khvcoqti	30	27	use	use	NN
cord-345762-khvcoqti	30	28	of	of	IN
cord-345762-khvcoqti	30	29	surrogate	surrogate	JJ
cord-345762-khvcoqti	30	30	outcome	outcome	NN
cord-345762-khvcoqti	30	31	measures	measure	NNS
cord-345762-khvcoqti	30	32	(	(	-LRB-
cord-345762-khvcoqti	30	33	such	such	JJ
cord-345762-khvcoqti	30	34	as	as	IN
cord-345762-khvcoqti	30	35	reduction	reduction	NN
cord-345762-khvcoqti	30	36	in	in	IN
cord-345762-khvcoqti	30	37	viral	viral	JJ
cord-345762-khvcoqti	30	38	shedding	shedding	NN
cord-345762-khvcoqti	30	39	,	,	,
cord-345762-khvcoqti	30	40	radiological	radiological	JJ
cord-345762-khvcoqti	30	41	progression	progression	NN
cord-345762-khvcoqti	30	42	,	,	,
cord-345762-khvcoqti	30	43	numbers	number	NNS
cord-345762-khvcoqti	30	44	of	of	IN
cord-345762-khvcoqti	30	45	'	'	``
cord-345762-khvcoqti	30	46	cough	cough	NN
cord-345762-khvcoqti	30	47	days	day	NNS
cord-345762-khvcoqti	30	48	'	'	POS
cord-345762-khvcoqti	30	49	14	14	CD
cord-345762-khvcoqti	30	50	)	)	-RRB-
cord-345762-khvcoqti	30	51	,	,	,
cord-345762-khvcoqti	30	52	ad	ad	FW
cord-345762-khvcoqti	30	53	hoc	hoc	FW
cord-345762-khvcoqti	30	54	administration	administration	NN
cord-345762-khvcoqti	30	55	of	of	IN
cord-345762-khvcoqti	30	56	a	a	DT
cord-345762-khvcoqti	30	57	host	host	NN
cord-345762-khvcoqti	30	58	of	of	IN
cord-345762-khvcoqti	30	59	cotreatments	cotreatment	NNS
cord-345762-khvcoqti	30	60	(	(	-LRB-
cord-345762-khvcoqti	30	61	such	such	JJ
cord-345762-khvcoqti	30	62	as	as	IN
cord-345762-khvcoqti	30	63	steroids	steroid	NNS
cord-345762-khvcoqti	30	64	,	,	,
cord-345762-khvcoqti	30	65	various	various	JJ
cord-345762-khvcoqti	30	66	antiviral	antiviral	JJ
cord-345762-khvcoqti	30	67	drugs	drug	NNS
cord-345762-khvcoqti	30	68	and	and	CC
cord-345762-khvcoqti	30	69	antibiotics	antibiotic	NNS
cord-345762-khvcoqti	30	70	)	)	-RRB-
cord-345762-khvcoqti	30	71	,	,	,
cord-345762-khvcoqti	30	72	underpowered	underpowere	VBD
cord-345762-khvcoqti	30	73	subgroup	subgroup	NN
cord-345762-khvcoqti	30	74	analyses	analysis	NNS
cord-345762-khvcoqti	30	75	,	,	,
cord-345762-khvcoqti	30	76	early	early	JJ
cord-345762-khvcoqti	30	77	termination	termination	NN
cord-345762-khvcoqti	30	78	and	and	CC
cord-345762-khvcoqti	30	79	short	short	JJ
cord-345762-khvcoqti	30	80	in	in	IN
cord-345762-khvcoqti	30	81	-	-	HYPH
cord-345762-khvcoqti	30	82	hospital	hospital	NN
cord-345762-khvcoqti	30	83	duration	duration	NN
cord-345762-khvcoqti	30	84	.	.	.
cord-345762-khvcoqti	31	1	Unsurprisingly	unsurprisingly	RB
cord-345762-khvcoqti	31	2	,	,	,
cord-345762-khvcoqti	31	3	such	such	JJ
cord-345762-khvcoqti	31	4	flaws	flaw	NNS
cord-345762-khvcoqti	31	5	cause	cause	VBP
cord-345762-khvcoqti	31	6	different	different	JJ
cord-345762-khvcoqti	31	7	trials	trial	NNS
cord-345762-khvcoqti	31	8	of	of	IN
cord-345762-khvcoqti	31	9	the	the	DT
cord-345762-khvcoqti	31	10	same	same	JJ
cord-345762-khvcoqti	31	11	therapy	therapy	NN
cord-345762-khvcoqti	31	12	,	,	,
cord-345762-khvcoqti	31	13	such	such	JJ
cord-345762-khvcoqti	31	14	as	as	IN
cord-345762-khvcoqti	31	15	hydroxychloroquine	hydroxychloroquine	NNP
cord-345762-khvcoqti	31	16	,	,	,
cord-345762-khvcoqti	31	17	to	to	TO
cord-345762-khvcoqti	31	18	report	report	VB
cord-345762-khvcoqti	31	19	conflicting	conflict	VBG
cord-345762-khvcoqti	31	20	findings	finding	NNS
cord-345762-khvcoqti	31	21	.	.	.
cord-345762-khvcoqti	32	1	14	14	CD
cord-345762-khvcoqti	32	2	,	,	,
cord-345762-khvcoqti	32	3	15	15	CD
cord-345762-khvcoqti	32	4	Too	too	RB
cord-345762-khvcoqti	32	5	much	much	JJ
cord-345762-khvcoqti	32	6	faith	faith	NN
cord-345762-khvcoqti	32	7	has	have	VBZ
cord-345762-khvcoqti	32	8	been	be	VBN
cord-345762-khvcoqti	32	9	prematurely	prematurely	RB
cord-345762-khvcoqti	32	10	placed	place	VBN
cord-345762-khvcoqti	32	11	on	on	IN
cord-345762-khvcoqti	32	12	what	what	WP
cord-345762-khvcoqti	32	13	seemed	seem	VBD
cord-345762-khvcoqti	32	14	to	to	TO
cord-345762-khvcoqti	32	15	be	be	VB
cord-345762-khvcoqti	32	16	useful	useful	JJ
cord-345762-khvcoqti	32	17	therapies	therapy	NNS
cord-345762-khvcoqti	32	18	,	,	,
cord-345762-khvcoqti	32	19	as	as	IN
cord-345762-khvcoqti	32	20	exemplified	exemplify	VBN
cord-345762-khvcoqti	32	21	by	by	IN
cord-345762-khvcoqti	32	22	the	the	DT
cord-345762-khvcoqti	32	23	off	off	JJ
cord-345762-khvcoqti	32	24	-	-	HYPH
cord-345762-khvcoqti	32	25	label	label	NN
cord-345762-khvcoqti	32	26	use	use	NN
cord-345762-khvcoqti	32	27	of	of	IN
cord-345762-khvcoqti	32	28	corticosteroids	corticosteroid	NNS
cord-345762-khvcoqti	32	29	and	and	CC
cord-345762-khvcoqti	32	30	hydroxy	hydroxy	JJ
cord-345762-khvcoqti	32	31	chloroquine	chloroquine	NN
cord-345762-khvcoqti	32	32	,	,	,
cord-345762-khvcoqti	32	33	16	16	CD
cord-345762-khvcoqti	32	34	despite	despite	IN
cord-345762-khvcoqti	32	35	evidence	evidence	NN
cord-345762-khvcoqti	32	36	of	of	IN
cord-345762-khvcoqti	32	37	no	no	DT
cord-345762-khvcoqti	32	38	effect	effect	NN
cord-345762-khvcoqti	32	39	17	17	CD
cord-345762-khvcoqti	32	40	or	or	CC
cord-345762-khvcoqti	32	41	even	even	RB
cord-345762-khvcoqti	32	42	possible	possible	JJ
cord-345762-khvcoqti	32	43	excess	excess	JJ
cord-345762-khvcoqti	32	44	mortality	mortality	NN
cord-345762-khvcoqti	32	45	.	.	.
cord-345762-khvcoqti	33	1	18	18	CD
cord-345762-khvcoqti	33	2	Such	such	JJ
cord-345762-khvcoqti	33	3	publicity	publicity	NN
cord-345762-khvcoqti	33	4	also	also	RB
cord-345762-khvcoqti	33	5	led	lead	VBD
cord-345762-khvcoqti	33	6	to	to	IN
cord-345762-khvcoqti	33	7	inappropriate	inappropriate	JJ
cord-345762-khvcoqti	33	8	overprescribing	overprescribing	NN
cord-345762-khvcoqti	33	9	of	of	IN
cord-345762-khvcoqti	33	10	hydroxychloroquine	hydroxychloroquine	NN
cord-345762-khvcoqti	33	11	to	to	TO
cord-345762-khvcoqti	33	12	treat	treat	VB
cord-345762-khvcoqti	33	13	mild	mild	JJ
cord-345762-khvcoqti	33	14	cases	case	NNS
cord-345762-khvcoqti	33	15	and	and	CC
cord-345762-khvcoqti	33	16	even	even	RB
cord-345762-khvcoqti	33	17	for	for	IN
cord-345762-khvcoqti	33	18	prophylaxis	prophylaxis	NN
cord-345762-khvcoqti	33	19	,	,	,
cord-345762-khvcoqti	33	20	leading	lead	VBG
cord-345762-khvcoqti	33	21	to	to	IN
cord-345762-khvcoqti	33	22	shortages	shortage	NNS
cord-345762-khvcoqti	33	23	of	of	IN
cord-345762-khvcoqti	33	24	the	the	DT
cord-345762-khvcoqti	33	25	drug	drug	NN
cord-345762-khvcoqti	33	26	for	for	IN
cord-345762-khvcoqti	33	27	patients	patient	NNS
cord-345762-khvcoqti	33	28	with	with	IN
cord-345762-khvcoqti	33	29	proven	prove	VBN
cord-345762-khvcoqti	33	30	indications	indication	NNS
cord-345762-khvcoqti	33	31	for	for	IN
cord-345762-khvcoqti	33	32	its	-PRON-	PRP$
cord-345762-khvcoqti	33	33	use	use	NN
cord-345762-khvcoqti	33	34	,	,	,
cord-345762-khvcoqti	33	35	such	such	JJ
cord-345762-khvcoqti	33	36	as	as	IN
cord-345762-khvcoqti	33	37	rheumatoid	rheumatoid	JJ
cord-345762-khvcoqti	33	38	arthritis	arthritis	NN
cord-345762-khvcoqti	33	39	and	and	CC
cord-345762-khvcoqti	33	40	systemic	systemic	JJ
cord-345762-khvcoqti	33	41	lupus	lupus	NN
cord-345762-khvcoqti	33	42	erythematosus	erythematosus	NN
cord-345762-khvcoqti	33	43	.	.	.
cord-345762-khvcoqti	34	1	Hopefully	hopefully	RB
cord-345762-khvcoqti	34	2	,	,	,
cord-345762-khvcoqti	34	3	the	the	DT
cord-345762-khvcoqti	34	4	same	same	JJ
cord-345762-khvcoqti	34	5	problems	problem	NNS
cord-345762-khvcoqti	34	6	will	will	MD
cord-345762-khvcoqti	34	7	not	not	RB
cord-345762-khvcoqti	34	8	occur	occur	VB
cord-345762-khvcoqti	34	9	with	with	IN
cord-345762-khvcoqti	34	10	remdesivir	remdesivir	NNP
cord-345762-khvcoqti	34	11	,	,	,
cord-345762-khvcoqti	34	12	whichdespite	whichdespite	NNP
cord-345762-khvcoqti	34	13	limited	limited	JJ
cord-345762-khvcoqti	34	14	and	and	CC
cord-345762-khvcoqti	34	15	conflicting	conflict	VBG
cord-345762-khvcoqti	34	16	evidence	evidence	NN
cord-345762-khvcoqti	34	17	of	of	IN
cord-345762-khvcoqti	34	18	clinical	clinical	JJ
cord-345762-khvcoqti	34	19	improvement	improvement	NN
cord-345762-khvcoqti	34	20	from	from	IN
cord-345762-khvcoqti	34	21	only	only	RB
cord-345762-khvcoqti	34	22	two	two	CD
cord-345762-khvcoqti	34	23	placebo	placebo	NN
cord-345762-khvcoqti	34	24	-	-	HYPH
cord-345762-khvcoqti	34	25	controlled	control	VBN
cord-345762-khvcoqti	34	26	RCT	RCT	NNP
cord-345762-khvcoqti	34	27	19	19	CD
cord-345762-khvcoqti	34	28	,	,	,
cord-345762-khvcoqti	34	29	20	20	CD
cord-345762-khvcoqti	34	30	and	and	CC
cord-345762-khvcoqti	34	31	one	one	CD
cord-345762-khvcoqti	34	32	non	non	JJ
cord-345762-khvcoqti	34	33	-	-	JJ
cord-345762-khvcoqti	34	34	controlled	controlled	JJ
cord-345762-khvcoqti	34	35	cohort	cohort	NN
cord-345762-khvcoqti	34	36	study	study	NN
cord-345762-khvcoqti	34	37	5has	5has	NNP
cord-345762-khvcoqti	34	38	now	now	RB
cord-345762-khvcoqti	34	39	become	become	VBP
cord-345762-khvcoqti	34	40	a	a	DT
cord-345762-khvcoqti	34	41	'	'	``
cord-345762-khvcoqti	34	42	standard	standard	NN
cord-345762-khvcoqti	34	43	of	of	IN
cord-345762-khvcoqti	34	44	care	care	NN
cord-345762-khvcoqti	34	45	'	'	''
cord-345762-khvcoqti	34	46	in	in	IN
cord-345762-khvcoqti	34	47	the	the	DT
cord-345762-khvcoqti	34	48	United	United	NNP
cord-345762-khvcoqti	34	49	States	States	NNP
cord-345762-khvcoqti	34	50	for	for	IN
cord-345762-khvcoqti	34	51	COVID-19	covid-19	JJ
cord-345762-khvcoqti	34	52	patients	patient	NNS
cord-345762-khvcoqti	34	53	with	with	IN
cord-345762-khvcoqti	34	54	severe	severe	JJ
cord-345762-khvcoqti	34	55	pneumonia	pneumonia	NN
cord-345762-khvcoqti	34	56	.	.	.
cord-345762-khvcoqti	35	1	The	the	DT
cord-345762-khvcoqti	35	2	urgency	urgency	NN
cord-345762-khvcoqti	35	3	to	to	TO
cord-345762-khvcoqti	35	4	investigate	investigate	VB
cord-345762-khvcoqti	35	5	and	and	CC
cord-345762-khvcoqti	35	6	report	report	VB
cord-345762-khvcoqti	35	7	therapeutic	therapeutic	JJ
cord-345762-khvcoqti	35	8	trials	trial	NNS
cord-345762-khvcoqti	35	9	during	during	IN
cord-345762-khvcoqti	35	10	a	a	DT
cord-345762-khvcoqti	35	11	pandemic	pandemic	NN
cord-345762-khvcoqti	35	12	is	be	VBZ
cord-345762-khvcoqti	35	13	not	not	RB
cord-345762-khvcoqti	35	14	surprising	surprising	JJ
cord-345762-khvcoqti	35	15	,	,	,
cord-345762-khvcoqti	35	16	but	but	CC
cord-345762-khvcoqti	35	17	the	the	DT
cord-345762-khvcoqti	35	18	human	human	JJ
cord-345762-khvcoqti	35	19	desire	desire	NN
cord-345762-khvcoqti	35	20	of	of	IN
cord-345762-khvcoqti	35	21	researchers	researcher	NNS
cord-345762-khvcoqti	35	22	and	and	CC
cord-345762-khvcoqti	35	23	journal	journal	NN
cord-345762-khvcoqti	35	24	editors	editor	NNS
cord-345762-khvcoqti	35	25	to	to	TO
cord-345762-khvcoqti	35	26	be	be	VB
cord-345762-khvcoqti	35	27	the	the	DT
cord-345762-khvcoqti	35	28	first	first	JJ
cord-345762-khvcoqti	35	29	to	to	TO
cord-345762-khvcoqti	35	30	report	report	VB
cord-345762-khvcoqti	35	31	and	and	CC
cord-345762-khvcoqti	35	32	publish	publish	VB
cord-345762-khvcoqti	35	33	potentially	potentially	RB
cord-345762-khvcoqti	35	34	ground	ground	NN
cord-345762-khvcoqti	35	35	-	-	HYPH
cord-345762-khvcoqti	35	36	breaking	break	VBG
cord-345762-khvcoqti	35	37	research	research	NN
cord-345762-khvcoqti	35	38	also	also	RB
cord-345762-khvcoqti	35	39	needs	need	VBZ
cord-345762-khvcoqti	35	40	consideration	consideration	NN
cord-345762-khvcoqti	35	41	.	.	.
cord-345762-khvcoqti	36	1	Many	many	JJ
cord-345762-khvcoqti	36	2	study	study	NN
cord-345762-khvcoqti	36	3	protocols	protocol	NNS
cord-345762-khvcoqti	36	4	are	be	VBP
cord-345762-khvcoqti	36	5	being	be	VBG
cord-345762-khvcoqti	36	6	designed	design	VBN
cord-345762-khvcoqti	36	7	in	in	IN
cord-345762-khvcoqti	36	8	haste	haste	NN
cord-345762-khvcoqti	36	9	by	by	IN
cord-345762-khvcoqti	36	10	inexperienced	inexperienced	JJ
cord-345762-khvcoqti	36	11	researchers	researcher	NNS
cord-345762-khvcoqti	36	12	,	,	,
cord-345762-khvcoqti	36	13	with	with	IN
cord-345762-khvcoqti	36	14	inadequate	inadequate	JJ
cord-345762-khvcoqti	36	15	attention	attention	NN
cord-345762-khvcoqti	36	16	being	be	VBG
cord-345762-khvcoqti	36	17	paid	pay	VBN
cord-345762-khvcoqti	36	18	to	to	IN
cord-345762-khvcoqti	36	19	both	both	DT
cord-345762-khvcoqti	36	20	methodological	methodological	JJ
cord-345762-khvcoqti	36	21	rigour	rigour	NN
cord-345762-khvcoqti	36	22	and	and	CC
cord-345762-khvcoqti	36	23	appropriate	appropriate	JJ
cord-345762-khvcoqti	36	24	informed	informed	JJ
cord-345762-khvcoqti	36	25	patient	patient	JJ
cord-345762-khvcoqti	36	26	consent	consent	NN
cord-345762-khvcoqti	36	27	.	.	.
cord-345762-khvcoqti	37	1	21	21	CD
cord-345762-khvcoqti	37	2	Unscrupulous	unscrupulous	JJ
cord-345762-khvcoqti	37	3	investigators	investigator	NNS
cord-345762-khvcoqti	37	4	have	have	VBP
cord-345762-khvcoqti	37	5	fabricated	fabricate	VBN
cord-345762-khvcoqti	37	6	or	or	CC
cord-345762-khvcoqti	37	7	manipulated	manipulate	VBN
cord-345762-khvcoqti	37	8	data	datum	NNS
cord-345762-khvcoqti	37	9	22	22	CD
cord-345762-khvcoqti	37	10	,	,	,
cord-345762-khvcoqti	37	11	23	23	CD
cord-345762-khvcoqti	37	12	or	or	CC
cord-345762-khvcoqti	37	13	submitted	submit	VBD
cord-345762-khvcoqti	37	14	duplicate	duplicate	JJ
cord-345762-khvcoqti	37	15	articles	article	NNS
cord-345762-khvcoqti	37	16	relating	relate	VBG
cord-345762-khvcoqti	37	17	to	to	IN
cord-345762-khvcoqti	37	18	the	the	DT
cord-345762-khvcoqti	37	19	same	same	JJ
cord-345762-khvcoqti	37	20	patient	patient	JJ
cord-345762-khvcoqti	37	21	populations	population	NNS
cord-345762-khvcoqti	37	22	,	,	,
cord-345762-khvcoqti	37	23	24	24	CD
cord-345762-khvcoqti	37	24	which	which	WDT
cord-345762-khvcoqti	37	25	imperils	imperil	VBZ
cord-345762-khvcoqti	37	26	the	the	DT
cord-345762-khvcoqti	37	27	accuracy	accuracy	NN
cord-345762-khvcoqti	37	28	of	of	IN
cord-345762-khvcoqti	37	29	subsequent	subsequent	JJ
cord-345762-khvcoqti	37	30	estimates	estimate	NNS
cord-345762-khvcoqti	37	31	of	of	IN
cord-345762-khvcoqti	37	32	therapeutic	therapeutic	JJ
cord-345762-khvcoqti	37	33	outcomes	outcome	NNS
cord-345762-khvcoqti	37	34	and	and	CC
cord-345762-khvcoqti	37	35	precludes	preclude	VBZ
cord-345762-khvcoqti	37	36	valid	valid	JJ
cord-345762-khvcoqti	37	37	meta	meta	JJ
cord-345762-khvcoqti	37	38	-	-	HYPH
cord-345762-khvcoqti	37	39	analyses	analysis	NNS
cord-345762-khvcoqti	37	40	if	if	IN
cord-345762-khvcoqti	37	41	individual	individual	JJ
cord-345762-khvcoqti	37	42	patient	patient	NN
cord-345762-khvcoqti	37	43	data	datum	NNS
cord-345762-khvcoqti	37	44	can	can	MD
cord-345762-khvcoqti	37	45	not	not	RB
cord-345762-khvcoqti	37	46	be	be	VB
cord-345762-khvcoqti	37	47	obtained	obtain	VBN
cord-345762-khvcoqti	37	48	to	to	TO
cord-345762-khvcoqti	37	49	reveal	reveal	VB
cord-345762-khvcoqti	37	50	such	such	JJ
cord-345762-khvcoqti	37	51	duplication	duplication	NN
cord-345762-khvcoqti	37	52	.	.	.
cord-345762-khvcoqti	38	1	The	the	DT
cord-345762-khvcoqti	38	2	websites	website	NNS
cord-345762-khvcoqti	38	3	of	of	IN
cord-345762-khvcoqti	38	4	many	many	JJ
cord-345762-khvcoqti	38	5	mainstream	mainstream	JJ
cord-345762-khvcoqti	38	6	journals	journal	NNS
cord-345762-khvcoqti	38	7	now	now	RB
cord-345762-khvcoqti	38	8	feature	feature	VBP
cord-345762-khvcoqti	38	9	COVID-19	covid-19	JJ
cord-345762-khvcoqti	38	10	resource	resource	NN
cord-345762-khvcoqti	38	11	centres	centre	NNS
cord-345762-khvcoqti	38	12	containing	contain	VBG
cord-345762-khvcoqti	38	13	pre	pre	NNS
cord-345762-khvcoqti	38	14	-	-	NNS
cord-345762-khvcoqti	38	15	proofs	proofs	JJ
cord-345762-khvcoqti	38	16	and	and	CC
cord-345762-khvcoqti	38	17	early	early	JJ
cord-345762-khvcoqti	38	18	views	view	NNS
cord-345762-khvcoqti	38	19	of	of	IN
cord-345762-khvcoqti	38	20	articles	article	NNS
cord-345762-khvcoqti	38	21	that	that	WDT
cord-345762-khvcoqti	38	22	help	help	VBP
cord-345762-khvcoqti	38	23	boost	boost	VB
cord-345762-khvcoqti	38	24	their	-PRON-	PRP$
cord-345762-khvcoqti	38	25	citation	citation	NN
cord-345762-khvcoqti	38	26	and	and	CC
cord-345762-khvcoqti	38	27	website	website	NN
cord-345762-khvcoqti	38	28	hit	hit	VBN
cord-345762-khvcoqti	38	29	rates	rate	NNS
cord-345762-khvcoqti	38	30	,	,	,
cord-345762-khvcoqti	38	31	but	but	CC
cord-345762-khvcoqti	38	32	without	without	IN
cord-345762-khvcoqti	38	33	any	any	DT
cord-345762-khvcoqti	38	34	ranking	ranking	JJ
cord-345762-khvcoqti	38	35	or	or	CC
cord-345762-khvcoqti	38	36	labelling	labelling	NN
cord-345762-khvcoqti	38	37	of	of	IN
cord-345762-khvcoqti	38	38	articles	article	NNS
cord-345762-khvcoqti	38	39	according	accord	VBG
cord-345762-khvcoqti	38	40	to	to	IN
cord-345762-khvcoqti	38	41	quality	quality	NN
cord-345762-khvcoqti	38	42	.	.	.
cord-345762-khvcoqti	39	1	Regulators	regulator	NNS
cord-345762-khvcoqti	39	2	,	,	,
cord-345762-khvcoqti	39	3	such	such	JJ
cord-345762-khvcoqti	39	4	as	as	IN
cord-345762-khvcoqti	39	5	the	the	DT
cord-345762-khvcoqti	39	6	US	US	NNP
cord-345762-khvcoqti	39	7	Food	Food	NNP
cord-345762-khvcoqti	39	8	and	and	CC
cord-345762-khvcoqti	39	9	Drug	Drug	NNP
cord-345762-khvcoqti	39	10	Administration	Administration	NNP
cord-345762-khvcoqti	39	11	,	,	,
cord-345762-khvcoqti	39	12	are	be	VBP
cord-345762-khvcoqti	39	13	pressured	pressure	VBN
cord-345762-khvcoqti	39	14	to	to	TO
cord-345762-khvcoqti	39	15	expedite	expedite	VB
cord-345762-khvcoqti	39	16	approval	approval	NN
cord-345762-khvcoqti	39	17	of	of	IN
cord-345762-khvcoqti	39	18	investigational	investigational	JJ
cord-345762-khvcoqti	39	19	therapies	therapy	NNS
cord-345762-khvcoqti	39	20	under	under	IN
cord-345762-khvcoqti	39	21	emergency	emergency	NN
cord-345762-khvcoqti	39	22	user	user	NN
cord-345762-khvcoqti	39	23	access	access	NN
cord-345762-khvcoqti	39	24	or	or	CC
cord-345762-khvcoqti	39	25	compassionate	compassionate	JJ
cord-345762-khvcoqti	39	26	use	use	NN
cord-345762-khvcoqti	39	27	schemes	scheme	NNS
cord-345762-khvcoqti	39	28	.	.	.
cord-345762-khvcoqti	40	1	There	there	EX
cord-345762-khvcoqti	40	2	are	be	VBP
cord-345762-khvcoqti	40	3	many	many	JJ
cord-345762-khvcoqti	40	4	challenges	challenge	NNS
cord-345762-khvcoqti	40	5	to	to	IN
cord-345762-khvcoqti	40	6	conducting	conduct	VBG
cord-345762-khvcoqti	40	7	RCT	RCT	NNP
cord-345762-khvcoqti	40	8	in	in	IN
cord-345762-khvcoqti	40	9	a	a	DT
cord-345762-khvcoqti	40	10	pandemicrandomisation	pandemicrandomisation	NN
cord-345762-khvcoqti	40	11	to	to	IN
cord-345762-khvcoqti	40	12	placebo	placebo	NN
cord-345762-khvcoqti	40	13	seems	seem	VBZ
cord-345762-khvcoqti	40	14	unethical	unethical	JJ
cord-345762-khvcoqti	40	15	;	;	:
cord-345762-khvcoqti	40	16	conventional	conventional	JJ
cord-345762-khvcoqti	40	17	trials	trial	NNS
cord-345762-khvcoqti	40	18	are	be	VBP
cord-345762-khvcoqti	40	19	slow	slow	JJ
cord-345762-khvcoqti	40	20	and	and	CC
cord-345762-khvcoqti	40	21	cumbersome	cumbersome	JJ
cord-345762-khvcoqti	40	22	;	;	:
cord-345762-khvcoqti	40	23	and	and	CC
cord-345762-khvcoqti	40	24	conducting	conduct	VBG
cord-345762-khvcoqti	40	25	multi	multi	JJ
cord-345762-khvcoqti	40	26	-	-	JJ
cord-345762-khvcoqti	40	27	site	site	JJ
cord-345762-khvcoqti	40	28	trials	trial	NNS
cord-345762-khvcoqti	40	29	that	that	WDT
cord-345762-khvcoqti	40	30	require	require	VBP
cord-345762-khvcoqti	40	31	participating	participate	VBG
cord-345762-khvcoqti	40	32	researchers	researcher	NNS
cord-345762-khvcoqti	40	33	to	to	TO
cord-345762-khvcoqti	40	34	agree	agree	VB
cord-345762-khvcoqti	40	35	on	on	IN
cord-345762-khvcoqti	40	36	inclusion	inclusion	NN
cord-345762-khvcoqti	40	37	and	and	CC
cord-345762-khvcoqti	40	38	diagnostic	diagnostic	JJ
cord-345762-khvcoqti	40	39	criteria	criterion	NNS
cord-345762-khvcoqti	40	40	,	,	,
cord-345762-khvcoqti	40	41	drug	drug	NN
cord-345762-khvcoqti	40	42	administration	administration	NN
cord-345762-khvcoqti	40	43	schedules	schedule	NNS
cord-345762-khvcoqti	40	44	and	and	CC
cord-345762-khvcoqti	40	45	outcome	outcome	NN
cord-345762-khvcoqti	40	46	measures	measure	NNS
cord-345762-khvcoqti	40	47	is	be	VBZ
cord-345762-khvcoqti	40	48	particularly	particularly	RB
cord-345762-khvcoqti	40	49	challenging	challenging	JJ
cord-345762-khvcoqti	40	50	.	.	.
cord-345762-khvcoqti	41	1	This	this	DT
cord-345762-khvcoqti	41	2	multiplicity	multiplicity	NN
cord-345762-khvcoqti	41	3	of	of	IN
cord-345762-khvcoqti	41	4	study	study	NN
cord-345762-khvcoqti	41	5	designs	design	NNS
cord-345762-khvcoqti	41	6	also	also	RB
cord-345762-khvcoqti	41	7	poses	pose	VBZ
cord-345762-khvcoqti	41	8	difficulties	difficulty	NNS
cord-345762-khvcoqti	41	9	for	for	IN
cord-345762-khvcoqti	41	10	meta	meta	NN
cord-345762-khvcoqti	41	11	-	-	HYPH
cord-345762-khvcoqti	41	12	analysts	analyst	NNS
cord-345762-khvcoqti	41	13	trying	try	VBG
cord-345762-khvcoqti	41	14	to	to	TO
cord-345762-khvcoqti	41	15	render	render	VB
cord-345762-khvcoqti	41	16	estimates	estimate	NNS
cord-345762-khvcoqti	41	17	of	of	IN
cord-345762-khvcoqti	41	18	therapeutic	therapeutic	JJ
cord-345762-khvcoqti	41	19	effects	effect	NNS
cord-345762-khvcoqti	41	20	more	more	RBR
cord-345762-khvcoqti	41	21	precise	precise	JJ
cord-345762-khvcoqti	41	22	and	and	CC
cord-345762-khvcoqti	41	23	certain	certain	JJ
cord-345762-khvcoqti	41	24	.	.	.
cord-345762-khvcoqti	42	1	So	so	RB
cord-345762-khvcoqti	42	2	how	how	WRB
cord-345762-khvcoqti	42	3	can	can	MD
cord-345762-khvcoqti	42	4	RCT	RCT	NNP
cord-345762-khvcoqti	42	5	be	be	VB
cord-345762-khvcoqti	42	6	rendered	render	VBN
cord-345762-khvcoqti	42	7	more	more	RBR
cord-345762-khvcoqti	42	8	doable	doable	JJ
cord-345762-khvcoqti	42	9	and	and	CC
cord-345762-khvcoqti	42	10	informative	informative	JJ
cord-345762-khvcoqti	42	11	during	during	IN
cord-345762-khvcoqti	42	12	a	a	DT
cord-345762-khvcoqti	42	13	pandemic	pandemic	NN
cord-345762-khvcoqti	42	14	?	?	.
cord-345762-khvcoqti	43	1	First	first	RB
cord-345762-khvcoqti	43	2	,	,	,
cord-345762-khvcoqti	43	3	trialists	trialist	NNS
cord-345762-khvcoqti	43	4	should	should	MD
cord-345762-khvcoqti	43	5	wait	wait	VB
cord-345762-khvcoqti	43	6	until	until	IN
cord-345762-khvcoqti	43	7	sufficient	sufficient	JJ
cord-345762-khvcoqti	43	8	data	datum	NNS
cord-345762-khvcoqti	43	9	have	have	VBP
cord-345762-khvcoqti	43	10	been	be	VBN
cord-345762-khvcoqti	43	11	gathered	gather	VBN
cord-345762-khvcoqti	43	12	to	to	TO
cord-345762-khvcoqti	43	13	allow	allow	VB
cord-345762-khvcoqti	43	14	a	a	DT
cord-345762-khvcoqti	43	15	better	well	JJR
cord-345762-khvcoqti	43	16	understanding	understanding	NN
cord-345762-khvcoqti	43	17	of	of	IN
cord-345762-khvcoqti	43	18	the	the	DT
cord-345762-khvcoqti	43	19	disease	disease	NN
cord-345762-khvcoqti	43	20	process	process	NN
cord-345762-khvcoqti	43	21	and	and	CC
cord-345762-khvcoqti	43	22	its	-PRON-	PRP$
cord-345762-khvcoqti	43	23	natural	natural	JJ
cord-345762-khvcoqti	43	24	history	history	NN
cord-345762-khvcoqti	43	25	and	and	CC
cord-345762-khvcoqti	43	26	then	then	RB
cord-345762-khvcoqti	43	27	use	use	VB
cord-345762-khvcoqti	43	28	this	this	DT
cord-345762-khvcoqti	43	29	to	to	TO
cord-345762-khvcoqti	43	30	design	design	VB
cord-345762-khvcoqti	43	31	more	more	RBR
cord-345762-khvcoqti	43	32	definitive	definitive	JJ
cord-345762-khvcoqti	43	33	trials	trial	NNS
cord-345762-khvcoqti	43	34	.	.	.
cord-345762-khvcoqti	44	1	Based	base	VBN
cord-345762-khvcoqti	44	2	on	on	IN
cord-345762-khvcoqti	44	3	the	the	DT
cord-345762-khvcoqti	44	4	assumption	assumption	NN
cord-345762-khvcoqti	44	5	that	that	IN
cord-345762-khvcoqti	44	6	SARS	SARS	NNP
cord-345762-khvcoqti	44	7	-	-	HYPH
cord-345762-khvcoqti	44	8	CoV-2	CoV-2	NNP
cord-345762-khvcoqti	44	9	was	be	VBD
cord-345762-khvcoqti	44	10	a	a	DT
cord-345762-khvcoqti	44	11	coronavirus	coronavirus	NN
cord-345762-khvcoqti	44	12	similar	similar	JJ
cord-345762-khvcoqti	44	13	to	to	IN
cord-345762-khvcoqti	44	14	those	those	DT
cord-345762-khvcoqti	44	15	that	that	WDT
cord-345762-khvcoqti	44	16	caused	cause	VBD
cord-345762-khvcoqti	44	17	Severe	severe	JJ
cord-345762-khvcoqti	44	18	Acute	acute	JJ
cord-345762-khvcoqti	44	19	Respiratory	Respiratory	NNP
cord-345762-khvcoqti	44	20	Syndrome	Syndrome	NNP
cord-345762-khvcoqti	44	21	(	(	-LRB-
cord-345762-khvcoqti	44	22	SARS	SARS	NNP
cord-345762-khvcoqti	44	23	)	)	-RRB-
cord-345762-khvcoqti	44	24	and	and	CC
cord-345762-khvcoqti	44	25	Middle	Middle	NNP
cord-345762-khvcoqti	44	26	East	East	NNP
cord-345762-khvcoqti	44	27	Respiratory	Respiratory	NNP
cord-345762-khvcoqti	44	28	Syndrome	Syndrome	NNP
cord-345762-khvcoqti	44	29	(	(	-LRB-
cord-345762-khvcoqti	44	30	MERS	MERS	NNP
cord-345762-khvcoqti	44	31	)	)	-RRB-
cord-345762-khvcoqti	44	32	,	,	,
cord-345762-khvcoqti	44	33	drugs	drug	NNS
cord-345762-khvcoqti	44	34	that	that	WDT
cord-345762-khvcoqti	44	35	had	have	VBD
cord-345762-khvcoqti	44	36	shown	show	VBN
cord-345762-khvcoqti	44	37	antiviral	antiviral	JJ
cord-345762-khvcoqti	44	38	effects	effect	NNS
cord-345762-khvcoqti	44	39	on	on	IN
cord-345762-khvcoqti	44	40	the	the	DT
cord-345762-khvcoqti	44	41	latter	latter	JJ
cord-345762-khvcoqti	44	42	,	,	,
cord-345762-khvcoqti	44	43	at	at	IN
cord-345762-khvcoqti	44	44	least	least	JJS
cord-345762-khvcoqti	44	45	in	in	IN
cord-345762-khvcoqti	44	46	vitro	vitro	FW
cord-345762-khvcoqti	44	47	,	,	,
cord-345762-khvcoqti	44	48	were	be	VBD
cord-345762-khvcoqti	44	49	quickly	quickly	RB
cord-345762-khvcoqti	44	50	repurposed	repurpose	VBN
cord-345762-khvcoqti	44	51	to	to	TO
cord-345762-khvcoqti	44	52	treat	treat	VB
cord-345762-khvcoqti	44	53	the	the	DT
cord-345762-khvcoqti	44	54	former	former	JJ
cord-345762-khvcoqti	44	55	,	,	,
cord-345762-khvcoqti	44	56	and	and	CC
cord-345762-khvcoqti	44	57	their	-PRON-	PRP$
cord-345762-khvcoqti	44	58	effects	effect	NNS
cord-345762-khvcoqti	44	59	were	be	VBD
cord-345762-khvcoqti	44	60	assessed	assess	VBN
cord-345762-khvcoqti	44	61	in	in	IN
cord-345762-khvcoqti	44	62	observational	observational	JJ
cord-345762-khvcoqti	44	63	studies	study	NNS
cord-345762-khvcoqti	44	64	.	.	.
cord-345762-khvcoqti	45	1	It	-PRON-	PRP
cord-345762-khvcoqti	45	2	has	have	VBZ
cord-345762-khvcoqti	45	3	now	now	RB
cord-345762-khvcoqti	45	4	become	become	VBN
cord-345762-khvcoqti	45	5	clear	clear	JJ
cord-345762-khvcoqti	45	6	that	that	IN
cord-345762-khvcoqti	45	7	,	,	,
cord-345762-khvcoqti	45	8	while	while	IN
cord-345762-khvcoqti	45	9	sharing	share	VBG
cord-345762-khvcoqti	45	10	many	many	JJ
cord-345762-khvcoqti	45	11	traits	trait	NNS
cord-345762-khvcoqti	45	12	,	,	,
cord-345762-khvcoqti	45	13	SARS	SARS	NNP
cord-345762-khvcoqti	45	14	-	-	HYPH
cord-345762-khvcoqti	45	15	CoV-2	CoV-2	NNP
cord-345762-khvcoqti	45	16	is	be	VBZ
cord-345762-khvcoqti	45	17	genetically	genetically	RB
cord-345762-khvcoqti	45	18	different	different	JJ
cord-345762-khvcoqti	45	19	to	to	IN
cord-345762-khvcoqti	45	20	its	-PRON-	PRP$
cord-345762-khvcoqti	45	21	predecessors	predecessor	NNS
cord-345762-khvcoqti	45	22	,	,	,
cord-345762-khvcoqti	45	23	as	as	IN
cord-345762-khvcoqti	45	24	are	be	VBP
cord-345762-khvcoqti	45	25	the	the	DT
cord-345762-khvcoqti	45	26	varied	varied	JJ
cord-345762-khvcoqti	45	27	clinical	clinical	JJ
cord-345762-khvcoqti	45	28	manifestations	manifestation	NNS
cord-345762-khvcoqti	45	29	of	of	IN
cord-345762-khvcoqti	45	30	infection	infection	NN
cord-345762-khvcoqti	45	31	,	,	,
cord-345762-khvcoqti	45	32	such	such	JJ
cord-345762-khvcoqti	45	33	as	as	IN
cord-345762-khvcoqti	45	34	profound	profound	JJ
cord-345762-khvcoqti	45	35	hypoxia	hypoxia	NN
cord-345762-khvcoqti	45	36	,	,	,
cord-345762-khvcoqti	45	37	extensive	extensive	JJ
cord-345762-khvcoqti	45	38	inflammatory	inflammatory	JJ
cord-345762-khvcoqti	45	39	activation	activation	NN
cord-345762-khvcoqti	45	40	,	,	,
cord-345762-khvcoqti	45	41	endothelial	endothelial	JJ
cord-345762-khvcoqti	45	42	damage	damage	NN
cord-345762-khvcoqti	45	43	and	and	CC
cord-345762-khvcoqti	45	44	coagulopathies	coagulopathie	NNS
cord-345762-khvcoqti	45	45	.	.	.
cord-345762-khvcoqti	46	1	These	these	DT
cord-345762-khvcoqti	46	2	observations	observation	NNS
cord-345762-khvcoqti	46	3	suggest	suggest	VBP
cord-345762-khvcoqti	46	4	multiple	multiple	JJ
cord-345762-khvcoqti	46	5	pathogenic	pathogenic	JJ
cord-345762-khvcoqti	46	6	pathways	pathway	NNS
cord-345762-khvcoqti	46	7	activated	activate	VBN
cord-345762-khvcoqti	46	8	to	to	IN
cord-345762-khvcoqti	46	9	varying	vary	VBG
cord-345762-khvcoqti	46	10	degrees	degree	NNS
cord-345762-khvcoqti	46	11	across	across	IN
cord-345762-khvcoqti	46	12	different	different	JJ
cord-345762-khvcoqti	46	13	individuals	individual	NNS
cord-345762-khvcoqti	46	14	at	at	IN
cord-345762-khvcoqti	46	15	different	different	JJ
cord-345762-khvcoqti	46	16	times	time	NNS
cord-345762-khvcoqti	46	17	.	.	.
cord-345762-khvcoqti	47	1	Second	second	RB
cord-345762-khvcoqti	47	2	,	,	,
cord-345762-khvcoqti	47	3	this	this	DT
cord-345762-khvcoqti	47	4	complex	complex	JJ
cord-345762-khvcoqti	47	5	pathogenesis	pathogenesis	NN
cord-345762-khvcoqti	47	6	means	mean	VBZ
cord-345762-khvcoqti	47	7	that	that	IN
cord-345762-khvcoqti	47	8	no	no	DT
cord-345762-khvcoqti	47	9	single	single	JJ
cord-345762-khvcoqti	47	10	drug	drug	NN
cord-345762-khvcoqti	47	11	is	be	VBZ
cord-345762-khvcoqti	47	12	likely	likely	JJ
cord-345762-khvcoqti	47	13	to	to	TO
cord-345762-khvcoqti	47	14	be	be	VB
cord-345762-khvcoqti	47	15	effective	effective	JJ
cord-345762-khvcoqti	47	16	,	,	,
cord-345762-khvcoqti	47	17	and	and	CC
cord-345762-khvcoqti	47	18	even	even	RB
cord-345762-khvcoqti	47	19	for	for	IN
cord-345762-khvcoqti	47	20	multiple	multiple	JJ
cord-345762-khvcoqti	47	21	drugs	drug	NNS
cord-345762-khvcoqti	47	22	,	,	,
cord-345762-khvcoqti	47	23	significant	significant	JJ
cord-345762-khvcoqti	47	24	heterogeneity	heterogeneity	NN
cord-345762-khvcoqti	47	25	of	of	IN
cord-345762-khvcoqti	47	26	treatment	treatment	NN
cord-345762-khvcoqti	47	27	effects	effect	NNS
cord-345762-khvcoqti	47	28	is	be	VBZ
cord-345762-khvcoqti	47	29	likely	likely	JJ
cord-345762-khvcoqti	47	30	among	among	IN
cord-345762-khvcoqti	47	31	individuals	individual	NNS
cord-345762-khvcoqti	47	32	and	and	CC
cord-345762-khvcoqti	47	33	at	at	IN
cord-345762-khvcoqti	47	34	various	various	JJ
cord-345762-khvcoqti	47	35	stages	stage	NNS
cord-345762-khvcoqti	47	36	of	of	IN
cord-345762-khvcoqti	47	37	the	the	DT
cord-345762-khvcoqti	47	38	disease	disease	NN
cord-345762-khvcoqti	47	39	.	.	.
cord-345762-khvcoqti	48	1	Separating	separate	VBG
cord-345762-khvcoqti	48	2	out	out	RP
cord-345762-khvcoqti	48	3	these	these	DT
cord-345762-khvcoqti	48	4	effects	effect	NNS
cord-345762-khvcoqti	48	5	,	,	,
cord-345762-khvcoqti	48	6	and	and	CC
cord-345762-khvcoqti	48	7	determining	determine	VBG
cord-345762-khvcoqti	48	8	which	which	WDT
cord-345762-khvcoqti	48	9	drugs	drug	NNS
cord-345762-khvcoqti	48	10	to	to	TO
cord-345762-khvcoqti	48	11	use	use	VB
cord-345762-khvcoqti	48	12	and	and	CC
cord-345762-khvcoqti	48	13	when	when	WRB
cord-345762-khvcoqti	48	14	(	(	-LRB-
cord-345762-khvcoqti	48	15	early	early	RB
cord-345762-khvcoqti	48	16	in	in	IN
cord-345762-khvcoqti	48	17	the	the	DT
cord-345762-khvcoqti	48	18	disease	disease	NN
cord-345762-khvcoqti	48	19	course	course	NN
cord-345762-khvcoqti	48	20	or	or	CC
cord-345762-khvcoqti	48	21	only	only	RB
cord-345762-khvcoqti	48	22	at	at	IN
cord-345762-khvcoqti	48	23	deterioration	deterioration	NN
cord-345762-khvcoqti	48	24	)	)	-RRB-
cord-345762-khvcoqti	48	25	,	,	,
cord-345762-khvcoqti	48	26	will	will	MD
cord-345762-khvcoqti	48	27	likely	likely	RB
cord-345762-khvcoqti	48	28	require	require	VB
cord-345762-khvcoqti	48	29	large	large	JJ
cord-345762-khvcoqti	48	30	-	-	HYPH
cord-345762-khvcoqti	48	31	scale	scale	NN
cord-345762-khvcoqti	48	32	trials	trial	NNS
cord-345762-khvcoqti	48	33	with	with	IN
cord-345762-khvcoqti	48	34	multiple	multiple	JJ
cord-345762-khvcoqti	48	35	treatment	treatment	NN
cord-345762-khvcoqti	48	36	arms	arm	NNS
cord-345762-khvcoqti	48	37	that	that	WDT
cord-345762-khvcoqti	48	38	are	be	VBP
cord-345762-khvcoqti	48	39	sufficiently	sufficiently	RB
cord-345762-khvcoqti	48	40	powered	powered	JJ
cord-345762-khvcoqti	48	41	to	to	TO
cord-345762-khvcoqti	48	42	enable	enable	VB
cord-345762-khvcoqti	48	43	analyses	analysis	NNS
cord-345762-khvcoqti	48	44	of	of	IN
cord-345762-khvcoqti	48	45	primary	primary	JJ
cord-345762-khvcoqti	48	46	and	and	CC
cord-345762-khvcoqti	48	47	,	,	,
cord-345762-khvcoqti	48	48	where	where	WRB
cord-345762-khvcoqti	48	49	indicated	indicate	VBN
cord-345762-khvcoqti	48	50	,	,	,
cord-345762-khvcoqti	48	51	secondary	secondary	JJ
cord-345762-khvcoqti	48	52	outcomes	outcome	NNS
cord-345762-khvcoqti	48	53	across	across	IN
cord-345762-khvcoqti	48	54	different	different	JJ
cord-345762-khvcoqti	48	55	patient	patient	NN
cord-345762-khvcoqti	48	56	subgroups	subgroup	NNS
cord-345762-khvcoqti	48	57	.	.	.
cord-345762-khvcoqti	49	1	Conventional	conventional	JJ
cord-345762-khvcoqti	49	2	multi	multi	JJ
cord-345762-khvcoqti	49	3	-	-	JJ
cord-345762-khvcoqti	49	4	arm	arm	JJ
cord-345762-khvcoqti	49	5	trials	trial	NNS
cord-345762-khvcoqti	49	6	take	take	VBP
cord-345762-khvcoqti	49	7	time	time	NN
cord-345762-khvcoqti	49	8	and	and	CC
cord-345762-khvcoqti	49	9	expose	expose	VB
cord-345762-khvcoqti	49	10	patients	patient	NNS
cord-345762-khvcoqti	49	11	to	to	IN
cord-345762-khvcoqti	49	12	ineffective	ineffective	JJ
cord-345762-khvcoqti	49	13	or	or	CC
cord-345762-khvcoqti	49	14	even	even	RB
cord-345762-khvcoqti	49	15	harmful	harmful	JJ
cord-345762-khvcoqti	49	16	treatments	treatment	NNS
cord-345762-khvcoqti	49	17	for	for	IN
cord-345762-khvcoqti	49	18	the	the	DT
cord-345762-khvcoqti	49	19	duration	duration	NN
cord-345762-khvcoqti	49	20	of	of	IN
cord-345762-khvcoqti	49	21	the	the	DT
cord-345762-khvcoqti	49	22	trial	trial	NN
cord-345762-khvcoqti	49	23	in	in	IN
cord-345762-khvcoqti	49	24	the	the	DT
cord-345762-khvcoqti	49	25	absence	absence	NN
cord-345762-khvcoqti	49	26	of	of	IN
cord-345762-khvcoqti	49	27	frequent	frequent	JJ
cord-345762-khvcoqti	49	28	interim	interim	JJ
cord-345762-khvcoqti	49	29	analyses	analysis	NNS
cord-345762-khvcoqti	49	30	.	.	.
cord-345762-khvcoqti	50	1	Weighing	weigh	VBG
cord-345762-khvcoqti	50	2	the	the	DT
cord-345762-khvcoqti	50	3	pros	pro	NNS
cord-345762-khvcoqti	50	4	and	and	CC
cord-345762-khvcoqti	50	5	cons	con	NNS
cord-345762-khvcoqti	50	6	of	of	IN
cord-345762-khvcoqti	50	7	multiple	multiple	JJ
cord-345762-khvcoqti	50	8	competing	compete	VBG
cord-345762-khvcoqti	50	9	protocols	protocol	NNS
cord-345762-khvcoqti	50	10	also	also	RB
cord-345762-khvcoqti	50	11	wastes	waste	VBZ
cord-345762-khvcoqti	50	12	time	time	NN
cord-345762-khvcoqti	50	13	and	and	CC
cord-345762-khvcoqti	50	14	resources	resource	NNS
cord-345762-khvcoqti	50	15	.	.	.
cord-345762-khvcoqti	51	1	It	-PRON-	PRP
cord-345762-khvcoqti	51	2	would	would	MD
cord-345762-khvcoqti	51	3	be	be	VB
cord-345762-khvcoqti	51	4	more	more	RBR
cord-345762-khvcoqti	51	5	efficient	efficient	JJ
cord-345762-khvcoqti	51	6	to	to	TO
cord-345762-khvcoqti	51	7	use	use	VB
cord-345762-khvcoqti	51	8	designs	design	NNS
cord-345762-khvcoqti	51	9	that	that	WDT
cord-345762-khvcoqti	51	10	leverage	leverage	VBP
cord-345762-khvcoqti	51	11	a	a	DT
cord-345762-khvcoqti	51	12	common	common	JJ
cord-345762-khvcoqti	51	13	structure	structure	NN
cord-345762-khvcoqti	51	14	for	for	IN
cord-345762-khvcoqti	51	15	trial	trial	NN
cord-345762-khvcoqti	51	16	entry	entry	NN
cord-345762-khvcoqti	51	17	,	,	,
cord-345762-khvcoqti	51	18	data	datum	NNS
cord-345762-khvcoqti	51	19	collection	collection	NN
cord-345762-khvcoqti	51	20	and	and	CC
cord-345762-khvcoqti	51	21	testing	testing	NN
cord-345762-khvcoqti	51	22	of	of	IN
cord-345762-khvcoqti	51	23	multiple	multiple	JJ
cord-345762-khvcoqti	51	24	therapies	therapy	NNS
cord-345762-khvcoqti	51	25	.	.	.
cord-345762-khvcoqti	52	1	Adaptive	adaptive	JJ
cord-345762-khvcoqti	52	2	study	study	NN
cord-345762-khvcoqti	52	3	designs	design	NNS
cord-345762-khvcoqti	52	4	and	and	CC
cord-345762-khvcoqti	52	5	platform	platform	NN
cord-345762-khvcoqti	52	6	protocols	protocol	NNS
cord-345762-khvcoqti	52	7	allow	allow	VBP
cord-345762-khvcoqti	52	8	rapid	rapid	JJ
cord-345762-khvcoqti	52	9	cycle	cycle	NN
cord-345762-khvcoqti	52	10	testing	testing	NN
cord-345762-khvcoqti	52	11	of	of	IN
cord-345762-khvcoqti	52	12	different	different	JJ
cord-345762-khvcoqti	52	13	therapies	therapy	NNS
cord-345762-khvcoqti	52	14	using	use	VBG
cord-345762-khvcoqti	52	15	response	response	NN
cord-345762-khvcoqti	52	16	-	-	HYPH
cord-345762-khvcoqti	52	17	adaptive	adaptive	JJ
cord-345762-khvcoqti	52	18	randomisation	randomisation	NN
cord-345762-khvcoqti	52	19	(	(	-LRB-
cord-345762-khvcoqti	52	20	Box	Box	NNP
cord-345762-khvcoqti	52	21	2	2	CD
cord-345762-khvcoqti	52	22	)	)	-RRB-
cord-345762-khvcoqti	52	23	.	.	.
cord-345762-khvcoqti	53	1	25	25	CD
cord-345762-khvcoqti	53	2	,	,	,
cord-345762-khvcoqti	53	3	26	26	CD
cord-345762-khvcoqti	53	4	Such	such	JJ
cord-345762-khvcoqti	53	5	trials	trial	NNS
cord-345762-khvcoqti	53	6	take	take	VBP
cord-345762-khvcoqti	53	7	account	account	NN
cord-345762-khvcoqti	53	8	of	of	IN
cord-345762-khvcoqti	53	9	the	the	DT
cord-345762-khvcoqti	53	10	heterogeneity	heterogeneity	NN
cord-345762-khvcoqti	53	11	of	of	IN
cord-345762-khvcoqti	53	12	the	the	DT
cord-345762-khvcoqti	53	13	patient	patient	JJ
cord-345762-khvcoqti	53	14	population	population	NN
cord-345762-khvcoqti	53	15	(	(	-LRB-
cord-345762-khvcoqti	53	16	e.g.	e.g.	RB
cord-345762-khvcoqti	53	17	based	base	VBN
cord-345762-khvcoqti	53	18	on	on	IN
cord-345762-khvcoqti	53	19	age	age	NN
cord-345762-khvcoqti	53	20	or	or	CC
cord-345762-khvcoqti	53	21	other	other	JJ
cord-345762-khvcoqti	53	22	patient	patient	JJ
cord-345762-khvcoqti	53	23	characteristics	characteristic	NNS
cord-345762-khvcoqti	53	24	,	,	,
cord-345762-khvcoqti	53	25	illness	illness	NN
cord-345762-khvcoqti	53	26	severity	severity	NN
cord-345762-khvcoqti	53	27	,	,	,
cord-345762-khvcoqti	53	28	prognostic	prognostic	JJ
cord-345762-khvcoqti	53	29	factors	factor	NNS
cord-345762-khvcoqti	53	30	)	)	-RRB-
cord-345762-khvcoqti	53	31	and	and	CC
cord-345762-khvcoqti	53	32	aim	aim	VBP
cord-345762-khvcoqti	53	33	to	to	TO
cord-345762-khvcoqti	53	34	find	find	VB
cord-345762-khvcoqti	53	35	,	,	,
cord-345762-khvcoqti	53	36	in	in	IN
cord-345762-khvcoqti	53	37	the	the	DT
cord-345762-khvcoqti	53	38	shortest	short	JJS
cord-345762-khvcoqti	53	39	time	time	NN
cord-345762-khvcoqti	53	40	possible	possible	JJ
cord-345762-khvcoqti	53	41	,	,	,
cord-345762-khvcoqti	53	42	the	the	DT
cord-345762-khvcoqti	53	43	best	good	JJS
cord-345762-khvcoqti	53	44	treatment	treatment	NN
cord-345762-khvcoqti	53	45	,	,	,
cord-345762-khvcoqti	53	46	or	or	CC
cord-345762-khvcoqti	53	47	combination	combination	NN
cord-345762-khvcoqti	53	48	of	of	IN
cord-345762-khvcoqti	53	49	treatments	treatment	NNS
cord-345762-khvcoqti	53	50	,	,	,
cord-345762-khvcoqti	53	51	for	for	IN
cord-345762-khvcoqti	53	52	patient	patient	JJ
cord-345762-khvcoqti	53	53	subgroups	subgroup	NNS
cord-345762-khvcoqti	53	54	defined	define	VBN
cord-345762-khvcoqti	53	55	by	by	IN
cord-345762-khvcoqti	53	56	these	these	DT
cord-345762-khvcoqti	53	57	variables	variable	NNS
cord-345762-khvcoqti	53	58	.	.	.
cord-345762-khvcoqti	54	1	What	what	WP
cord-345762-khvcoqti	54	2	may	may	MD
cord-345762-khvcoqti	54	3	take	take	VB
cord-345762-khvcoqti	54	4	12	12	CD
cord-345762-khvcoqti	54	5	months	month	NNS
cord-345762-khvcoqti	54	6	for	for	IN
cord-345762-khvcoqti	54	7	traditional	traditional	JJ
cord-345762-khvcoqti	54	8	two	two	CD
cord-345762-khvcoqti	54	9	-	-	HYPH
cord-345762-khvcoqti	54	10	arm	arm	NN
cord-345762-khvcoqti	54	11	sequential	sequential	JJ
cord-345762-khvcoqti	54	12	trials	trial	NNS
cord-345762-khvcoqti	54	13	to	to	TO
cord-345762-khvcoqti	54	14	produce	produce	VB
cord-345762-khvcoqti	54	15	an	an	DT
cord-345762-khvcoqti	54	16	answer	answer	NN
cord-345762-khvcoqti	54	17	could	could	MD
cord-345762-khvcoqti	54	18	be	be	VB
cord-345762-khvcoqti	54	19	reduced	reduce	VBN
cord-345762-khvcoqti	54	20	to	to	IN
cord-345762-khvcoqti	54	21	3	3	CD
cord-345762-khvcoqti	54	22	months	month	NNS
cord-345762-khvcoqti	54	23	using	use	VBG
cord-345762-khvcoqti	54	24	adaptive	adaptive	JJ
cord-345762-khvcoqti	54	25	designs	design	NNS
cord-345762-khvcoqti	54	26	.	.	.
cord-345762-khvcoqti	55	1	27	27	CD
cord-345762-khvcoqti	56	1	Such	such	JJ
cord-345762-khvcoqti	56	2	designs	design	NNS
cord-345762-khvcoqti	56	3	underpin	underpin	VBP
cord-345762-khvcoqti	56	4	several	several	JJ
cord-345762-khvcoqti	56	5	ongoing	ongoing	JJ
cord-345762-khvcoqti	56	6	COVID-19	covid-19	CD
cord-345762-khvcoqti	56	7	trials	trial	NNS
cord-345762-khvcoqti	56	8	,	,	,
cord-345762-khvcoqti	56	9	such	such	JJ
cord-345762-khvcoqti	56	10	as	as	IN
cord-345762-khvcoqti	56	11	AustralaSian	AustralaSian	NNP
cord-345762-khvcoqti	56	12	COVID-19	COVID-19	NNP
cord-345762-khvcoqti	56	13	trial	trial	NN
cord-345762-khvcoqti	56	14	(	(	-LRB-
cord-345762-khvcoqti	56	15	ASCOT	ASCOT	NNP
cord-345762-khvcoqti	56	16	)	)	-RRB-
cord-345762-khvcoqti	56	17	,	,	,
cord-345762-khvcoqti	56	18	28	28	CD
cord-345762-khvcoqti	56	19	Adaptive	adaptive	JJ
cord-345762-khvcoqti	56	20	COVID-19	COVID-19	NNP
cord-345762-khvcoqti	56	21	treatment	treatment	NN
cord-345762-khvcoqti	56	22	trial	trial	NN
cord-345762-khvcoqti	56	23	(	(	-LRB-
cord-345762-khvcoqti	56	24	ACTT	ACTT	NNP
cord-345762-khvcoqti	56	25	)	)	-RRB-
cord-345762-khvcoqti	56	26	,	,	,
cord-345762-khvcoqti	56	27	29	29	CD
cord-345762-khvcoqti	56	28	World	World	NNP
cord-345762-khvcoqti	56	29	Health	Health	NNP
cord-345762-khvcoqti	56	30	Organization	Organization	NNP
cord-345762-khvcoqti	56	31	Solidarity	Solidarity	NNP
cord-345762-khvcoqti	56	32	,	,	,
cord-345762-khvcoqti	56	33	30	30	CD
cord-345762-khvcoqti	56	34	Randomised	randomised	JJ
cord-345762-khvcoqti	56	35	embedded	embed	VBN
cord-345762-khvcoqti	56	36	multifactorial	multifactorial	JJ
cord-345762-khvcoqti	56	37	adaptive	adaptive	JJ
cord-345762-khvcoqti	56	38	platform	platform	NN
cord-345762-khvcoqti	56	39	trial	trial	NN
cord-345762-khvcoqti	56	40	for	for	IN
cord-345762-khvcoqti	56	41	community	community	NN
cord-345762-khvcoqti	56	42	-	-	HYPH
cord-345762-khvcoqti	56	43	acquired	acquire	VBN
cord-345762-khvcoqti	56	44	pneumonia	pneumonia	NN
cord-345762-khvcoqti	56	45	31	31	CD
cord-345762-khvcoqti	56	46	and	and	CC
cord-345762-khvcoqti	56	47	Randomised	randomised	JJ
cord-345762-khvcoqti	56	48	evaluation	evaluation	NN
cord-345762-khvcoqti	56	49	of	of	IN
cord-345762-khvcoqti	56	50	COVID-19	COVID-19	NNP
cord-345762-khvcoqti	56	51	therapy	therapy	NN
cord-345762-khvcoqti	56	52	(	(	-LRB-
cord-345762-khvcoqti	56	53	RECOVERY	RECOVERY	NNP
cord-345762-khvcoqti	56	54	)	)	-RRB-
cord-345762-khvcoqti	56	55	.	.	.
cord-345762-khvcoqti	57	1	32	32	CD
cord-345762-khvcoqti	57	2	Third	Third	NNP
cord-345762-khvcoqti	57	3	,	,	,
cord-345762-khvcoqti	57	4	trials	trial	NNS
cord-345762-khvcoqti	57	5	must	must	MD
cord-345762-khvcoqti	57	6	strive	strive	VB
cord-345762-khvcoqti	57	7	to	to	TO
cord-345762-khvcoqti	57	8	be	be	VB
cord-345762-khvcoqti	57	9	multi	multi	JJ
cord-345762-khvcoqti	57	10	-	-	JJ
cord-345762-khvcoqti	57	11	site	site	NN
cord-345762-khvcoqti	57	12	and	and	CC
cord-345762-khvcoqti	57	13	for	for	IN
cord-345762-khvcoqti	57	14	investigators	investigator	NNS
cord-345762-khvcoqti	57	15	to	to	TO
cord-345762-khvcoqti	57	16	share	share	VB
cord-345762-khvcoqti	57	17	individual	individual	JJ
cord-345762-khvcoqti	57	18	patient	patient	NN
cord-345762-khvcoqti	57	19	data	datum	NNS
cord-345762-khvcoqti	57	20	from	from	IN
cord-345762-khvcoqti	57	21	similar	similar	JJ
cord-345762-khvcoqti	57	22	trials	trial	NNS
cord-345762-khvcoqti	57	23	within	within	IN
cord-345762-khvcoqti	57	24	multi	multi	JJ
cord-345762-khvcoqti	57	25	-	-	JJ
cord-345762-khvcoqti	57	26	trialist	trialist	JJ
cord-345762-khvcoqti	57	27	collaborations	collaboration	NNS
cord-345762-khvcoqti	57	28	.	.	.
cord-345762-khvcoqti	58	1	These	these	DT
cord-345762-khvcoqti	58	2	groups	group	NNS
cord-345762-khvcoqti	58	3	need	need	VBP
cord-345762-khvcoqti	58	4	to	to	TO
cord-345762-khvcoqti	58	5	share	share	VB
cord-345762-khvcoqti	58	6	a	a	DT
cord-345762-khvcoqti	58	7	common	common	JJ
cord-345762-khvcoqti	58	8	taxonomy	taxonomy	NN
cord-345762-khvcoqti	58	9	of	of	IN
cord-345762-khvcoqti	58	10	outcome	outcome	NN
cord-345762-khvcoqti	58	11	measures	measure	NNS
cord-345762-khvcoqti	58	12	for	for	IN
cord-345762-khvcoqti	58	13	which	which	WDT
cord-345762-khvcoqti	58	14	the	the	DT
cord-345762-khvcoqti	58	15	minimal	minimal	JJ
cord-345762-khvcoqti	58	16	clinically	clinically	RB
cord-345762-khvcoqti	58	17	important	important	JJ
cord-345762-khvcoqti	58	18	difference	difference	NN
cord-345762-khvcoqti	58	19	between	between	IN
cord-345762-khvcoqti	58	20	Box	Box	NNP
cord-345762-khvcoqti	58	21	1	1	CD
cord-345762-khvcoqti	59	1	How	how	WRB
cord-345762-khvcoqti	59	2	a	a	DT
cord-345762-khvcoqti	59	3	flawed	flawed	JJ
cord-345762-khvcoqti	59	4	observational	observational	JJ
cord-345762-khvcoqti	59	5	study	study	NN
cord-345762-khvcoqti	59	6	engenders	engender	VBZ
cord-345762-khvcoqti	59	7	a	a	DT
cord-345762-khvcoqti	59	8	new	new	JJ
cord-345762-khvcoqti	59	9	but	but	CC
cord-345762-khvcoqti	59	10	unproven	unproven	JJ
cord-345762-khvcoqti	59	11	standard	standard	NN
cord-345762-khvcoqti	59	12	of	of	IN
cord-345762-khvcoqti	59	13	care	care	NN
cord-345762-khvcoqti	59	14	Researchers	researcher	NNS
cord-345762-khvcoqti	59	15	from	from	IN
cord-345762-khvcoqti	59	16	Mount	Mount	NNP
cord-345762-khvcoqti	59	17	Sinai	Sinai	NNP
cord-345762-khvcoqti	59	18	Hospital	Hospital	NNP
cord-345762-khvcoqti	59	19	in	in	IN
cord-345762-khvcoqti	59	20	New	New	NNP
cord-345762-khvcoqti	59	21	York	York	NNP
cord-345762-khvcoqti	59	22	City	City	NNP
cord-345762-khvcoqti	59	23	reported	report	VBD
cord-345762-khvcoqti	59	24	a	a	DT
cord-345762-khvcoqti	59	25	retrospective	retrospective	JJ
cord-345762-khvcoqti	59	26	observational	observational	JJ
cord-345762-khvcoqti	59	27	study	study	NN
cord-345762-khvcoqti	59	28	of	of	IN
cord-345762-khvcoqti	59	29	2773	2773	CD
cord-345762-khvcoqti	59	30	patients	patient	NNS
cord-345762-khvcoqti	59	31	with	with	IN
cord-345762-khvcoqti	59	32	COVID-19	COVID-19	NNP
cord-345762-khvcoqti	59	33	hospitalised	hospitalise	VBN
cord-345762-khvcoqti	59	34	in	in	IN
cord-345762-khvcoqti	59	35	March	March	NNP
cord-345762-khvcoqti	59	36	and	and	CC
cord-345762-khvcoqti	59	37	April	April	NNP
cord-345762-khvcoqti	59	38	2020	2020	CD
cord-345762-khvcoqti	59	39	.	.	.
cord-345762-khvcoqti	60	1	11	11	CD
cord-345762-khvcoqti	61	1	They	-PRON-	PRP
cord-345762-khvcoqti	61	2	found	find	VBD
cord-345762-khvcoqti	61	3	that	that	IN
cord-345762-khvcoqti	61	4	,	,	,
cord-345762-khvcoqti	61	5	among	among	IN
cord-345762-khvcoqti	61	6	patients	patient	NNS
cord-345762-khvcoqti	61	7	prescribed	prescribe	VBN
cord-345762-khvcoqti	61	8	therapeutic	therapeutic	JJ
cord-345762-khvcoqti	61	9	doses	dose	NNS
cord-345762-khvcoqti	61	10	of	of	IN
cord-345762-khvcoqti	61	11	anticoagulation	anticoagulation	NN
cord-345762-khvcoqti	61	12	(	(	-LRB-
cord-345762-khvcoqti	61	13	AC	AC	NNP
cord-345762-khvcoqti	61	14	)	)	-RRB-
cord-345762-khvcoqti	61	15	,	,	,
cord-345762-khvcoqti	61	16	the	the	DT
cord-345762-khvcoqti	61	17	in	in	IN
cord-345762-khvcoqti	61	18	-	-	HYPH
cord-345762-khvcoqti	61	19	hospital	hospital	NN
cord-345762-khvcoqti	61	20	mortality	mortality	NN
cord-345762-khvcoqti	61	21	was	be	VBD
cord-345762-khvcoqti	61	22	22.5	22.5	CD
cord-345762-khvcoqti	61	23	%	%	NN
cord-345762-khvcoqti	61	24	,	,	,
cord-345762-khvcoqti	61	25	with	with	IN
cord-345762-khvcoqti	61	26	a	a	DT
cord-345762-khvcoqti	61	27	median	median	JJ
cord-345762-khvcoqti	61	28	survival	survival	NN
cord-345762-khvcoqti	61	29	of	of	IN
cord-345762-khvcoqti	61	30	21	21	CD
cord-345762-khvcoqti	61	31	days	day	NNS
cord-345762-khvcoqti	61	32	,	,	,
cord-345762-khvcoqti	61	33	compared	compare	VBN
cord-345762-khvcoqti	61	34	with	with	IN
cord-345762-khvcoqti	61	35	22.8	22.8	CD
cord-345762-khvcoqti	61	36	%	%	NN
cord-345762-khvcoqti	61	37	and	and	CC
cord-345762-khvcoqti	61	38	a	a	DT
cord-345762-khvcoqti	61	39	lower	low	JJR
cord-345762-khvcoqti	61	40	median	median	JJ
cord-345762-khvcoqti	61	41	survival	survival	NN
cord-345762-khvcoqti	61	42	of	of	IN
cord-345762-khvcoqti	61	43	14	14	CD
cord-345762-khvcoqti	61	44	days	day	NNS
cord-345762-khvcoqti	61	45	among	among	IN
cord-345762-khvcoqti	61	46	patients	patient	NNS
cord-345762-khvcoqti	61	47	who	who	WP
cord-345762-khvcoqti	61	48	did	do	VBD
cord-345762-khvcoqti	61	49	not	not	RB
cord-345762-khvcoqti	61	50	receive	receive	VB
cord-345762-khvcoqti	61	51	this	this	DT
cord-345762-khvcoqti	61	52	treatment	treatment	NN
cord-345762-khvcoqti	61	53	.	.	.
cord-345762-khvcoqti	62	1	However	however	RB
cord-345762-khvcoqti	62	2	,	,	,
cord-345762-khvcoqti	62	3	among	among	IN
cord-345762-khvcoqti	62	4	patients	patient	NNS
cord-345762-khvcoqti	62	5	who	who	WP
cord-345762-khvcoqti	62	6	required	require	VBD
cord-345762-khvcoqti	62	7	mechanical	mechanical	JJ
cord-345762-khvcoqti	62	8	ventilation	ventilation	NN
cord-345762-khvcoqti	62	9	(	(	-LRB-
cord-345762-khvcoqti	62	10	n	n	NN
cord-345762-khvcoqti	62	11	=	=	SYM
cord-345762-khvcoqti	62	12	395	395	CD
cord-345762-khvcoqti	62	13	)	)	-RRB-
cord-345762-khvcoqti	62	14	,	,	,
cord-345762-khvcoqti	62	15	inhospital	inhospital	JJ
cord-345762-khvcoqti	62	16	mortality	mortality	NN
cord-345762-khvcoqti	62	17	was	be	VBD
cord-345762-khvcoqti	62	18	29	29	CD
cord-345762-khvcoqti	62	19	%	%	NN
cord-345762-khvcoqti	62	20	,	,	,
cord-345762-khvcoqti	62	21	with	with	IN
cord-345762-khvcoqti	62	22	a	a	DT
cord-345762-khvcoqti	62	23	median	median	JJ
cord-345762-khvcoqti	62	24	survival	survival	NN
cord-345762-khvcoqti	62	25	of	of	IN
cord-345762-khvcoqti	62	26	21	21	CD
cord-345762-khvcoqti	62	27	days	day	NNS
cord-345762-khvcoqti	62	28	,	,	,
cord-345762-khvcoqti	62	29	for	for	IN
cord-345762-khvcoqti	62	30	AC	ac	NN
cord-345762-khvcoqti	62	31	patients	patient	NNS
cord-345762-khvcoqti	62	32	but	but	CC
cord-345762-khvcoqti	62	33	63	63	CD
cord-345762-khvcoqti	62	34	%	%	NN
cord-345762-khvcoqti	62	35	,	,	,
cord-345762-khvcoqti	62	36	with	with	IN
cord-345762-khvcoqti	62	37	median	median	JJ
cord-345762-khvcoqti	62	38	survival	survival	NN
cord-345762-khvcoqti	62	39	of	of	IN
cord-345762-khvcoqti	62	40	9	9	CD
cord-345762-khvcoqti	62	41	days	day	NNS
cord-345762-khvcoqti	62	42	,	,	,
cord-345762-khvcoqti	62	43	in	in	IN
cord-345762-khvcoqti	62	44	non	non	JJ
cord-345762-khvcoqti	62	45	-	-	JJ
cord-345762-khvcoqti	62	46	AC	ac	JJ
cord-345762-khvcoqti	62	47	patients	patient	NNS
cord-345762-khvcoqti	62	48	.	.	.
cord-345762-khvcoqti	63	1	The	the	DT
cord-345762-khvcoqti	63	2	adjusted	adjusted	JJ
cord-345762-khvcoqti	63	3	hazard	hazard	NN
cord-345762-khvcoqti	63	4	ratio	ratio	NN
cord-345762-khvcoqti	63	5	for	for	IN
cord-345762-khvcoqti	63	6	mortality	mortality	NN
cord-345762-khvcoqti	63	7	was	be	VBD
cord-345762-khvcoqti	63	8	0.86	0.86	CD
cord-345762-khvcoqti	63	9	per	per	IN
cord-345762-khvcoqti	63	10	day	day	NN
cord-345762-khvcoqti	63	11	(	(	-LRB-
cord-345762-khvcoqti	63	12	95	95	CD
cord-345762-khvcoqti	63	13	%	%	NN
cord-345762-khvcoqti	63	14	confidence	confidence	NN
cord-345762-khvcoqti	63	15	interval	interval	NN
cord-345762-khvcoqti	63	16	0.82	0.82	CD
cord-345762-khvcoqti	63	17	-	-	HYPH
cord-345762-khvcoqti	63	18	0.89	0.89	CD
cord-345762-khvcoqti	63	19	,	,	,
cord-345762-khvcoqti	63	20	P	p	NN
cord-345762-khvcoqti	63	21	<	<	XX
cord-345762-khvcoqti	63	22	0.001	0.001	CD
cord-345762-khvcoqti	63	23	)	)	-RRB-
cord-345762-khvcoqti	63	24	,	,	,
cord-345762-khvcoqti	63	25	while	while	IN
cord-345762-khvcoqti	63	26	bleeding	bleed	VBG
cord-345762-khvcoqti	63	27	events	event	NNS
cord-345762-khvcoqti	63	28	were	be	VBD
cord-345762-khvcoqti	63	29	similar	similar	JJ
cord-345762-khvcoqti	63	30	in	in	IN
cord-345762-khvcoqti	63	31	both	both	DT
cord-345762-khvcoqti	63	32	groups	group	NNS
cord-345762-khvcoqti	63	33	:	:	:
cord-345762-khvcoqti	63	34	3	3	CD
cord-345762-khvcoqti	63	35	%	%	NN
cord-345762-khvcoqti	63	36	versus	versus	IN
cord-345762-khvcoqti	63	37	2	2	CD
cord-345762-khvcoqti	63	38	%	%	NN
cord-345762-khvcoqti	63	39	.	.	.
cord-345762-khvcoqti	64	1	The	the	DT
cord-345762-khvcoqti	64	2	authors	author	NNS
cord-345762-khvcoqti	64	3	acknowledged	acknowledge	VBD
cord-345762-khvcoqti	64	4	their	-PRON-	PRP$
cord-345762-khvcoqti	64	5	study	study	NN
cord-345762-khvcoqti	64	6	was	be	VBD
cord-345762-khvcoqti	64	7	limited	limit	VBN
cord-345762-khvcoqti	64	8	by	by	IN
cord-345762-khvcoqti	64	9	:	:	:
cord-345762-khvcoqti	64	10	indication	indication	NN
cord-345762-khvcoqti	64	11	bias	bias	NN
cord-345762-khvcoqti	64	12	for	for	IN
cord-345762-khvcoqti	64	13	AC	AC	NNP
cord-345762-khvcoqti	64	14	,	,	,
cord-345762-khvcoqti	64	15	with	with	IN
cord-345762-khvcoqti	64	16	no	no	DT
cord-345762-khvcoqti	64	17	reporting	reporting	NN
cord-345762-khvcoqti	64	18	of	of	IN
cord-345762-khvcoqti	64	19	why	why	WRB
cord-345762-khvcoqti	64	20	AC	AC	NNP
cord-345762-khvcoqti	64	21	was	be	VBD
cord-345762-khvcoqti	64	22	commenced	commence	VBN
cord-345762-khvcoqti	64	23	in	in	IN
cord-345762-khvcoqti	64	24	some	some	DT
cord-345762-khvcoqti	64	25	patients	patient	NNS
cord-345762-khvcoqti	64	26	but	but	CC
cord-345762-khvcoqti	64	27	not	not	RB
cord-345762-khvcoqti	64	28	others	other	NNS
cord-345762-khvcoqti	64	29	at	at	IN
cord-345762-khvcoqti	64	30	varying	vary	VBG
cord-345762-khvcoqti	64	31	times	time	NNS
cord-345762-khvcoqti	64	32	throughout	throughout	IN
cord-345762-khvcoqti	64	33	the	the	DT
cord-345762-khvcoqti	64	34	hospitalisation	hospitalisation	NN
cord-345762-khvcoqti	64	35	;	;	:
cord-345762-khvcoqti	64	36	non	non	JJ
cord-345762-khvcoqti	64	37	-	-	JJ
cord-345762-khvcoqti	64	38	standardised	standardised	JJ
cord-345762-khvcoqti	64	39	use	use	NN
cord-345762-khvcoqti	64	40	and	and	CC
cord-345762-khvcoqti	64	41	dosing	dosing	NN
cord-345762-khvcoqti	64	42	of	of	IN
cord-345762-khvcoqti	64	43	oral	oral	JJ
cord-345762-khvcoqti	64	44	,	,	,
cord-345762-khvcoqti	64	45	subcutaneous	subcutaneous	JJ
cord-345762-khvcoqti	64	46	or	or	CC
cord-345762-khvcoqti	64	47	intravenous	intravenous	JJ
cord-345762-khvcoqti	64	48	AC	ac	NN
cord-345762-khvcoqti	64	49	;	;	:
cord-345762-khvcoqti	64	50	subgroup	subgroup	NN
cord-345762-khvcoqti	64	51	analysis	analysis	NN
cord-345762-khvcoqti	64	52	with	with	IN
cord-345762-khvcoqti	64	53	a	a	DT
cord-345762-khvcoqti	64	54	lack	lack	NN
cord-345762-khvcoqti	64	55	of	of	IN
cord-345762-khvcoqti	64	56	metrics	metric	NNS
cord-345762-khvcoqti	64	57	to	to	TO
cord-345762-khvcoqti	64	58	further	further	RB
cord-345762-khvcoqti	64	59	classify	classify	VB
cord-345762-khvcoqti	64	60	illness	illness	NN
cord-345762-khvcoqti	64	61	severity	severity	NN
cord-345762-khvcoqti	64	62	in	in	IN
cord-345762-khvcoqti	64	63	the	the	DT
cord-345762-khvcoqti	64	64	mechanically	mechanically	RB
cord-345762-khvcoqti	64	65	ventilated	ventilate	VBN
cord-345762-khvcoqti	64	66	patients	patient	NNS
cord-345762-khvcoqti	64	67	;	;	:
cord-345762-khvcoqti	64	68	absence	absence	NN
cord-345762-khvcoqti	64	69	of	of	IN
cord-345762-khvcoqti	64	70	data	datum	NNS
cord-345762-khvcoqti	64	71	regarding	regard	VBG
cord-345762-khvcoqti	64	72	the	the	DT
cord-345762-khvcoqti	64	73	precise	precise	JJ
cord-345762-khvcoqti	64	74	cause	cause	NN
cord-345762-khvcoqti	64	75	of	of	IN
cord-345762-khvcoqti	64	76	death	death	NN
cord-345762-khvcoqti	64	77	(	(	-LRB-
cord-345762-khvcoqti	64	78	coagulopathy	coagulopathy	NN
cord-345762-khvcoqti	64	79	-	-	HYPH
cord-345762-khvcoqti	64	80	related	relate	VBN
cord-345762-khvcoqti	64	81	or	or	CC
cord-345762-khvcoqti	64	82	otherwise	otherwise	RB
cord-345762-khvcoqti	64	83	)	)	-RRB-
cord-345762-khvcoqti	64	84	;	;	:
cord-345762-khvcoqti	64	85	and	and	CC
cord-345762-khvcoqti	64	86	other	other	JJ
cord-345762-khvcoqti	64	87	unobserved	unobserved	JJ
cord-345762-khvcoqti	64	88	confounders	confounder	NNS
cord-345762-khvcoqti	64	89	.	.	.
cord-345762-khvcoqti	65	1	The	the	DT
cord-345762-khvcoqti	65	2	median	median	JJ
cord-345762-khvcoqti	65	3	duration	duration	NN
cord-345762-khvcoqti	65	4	of	of	IN
cord-345762-khvcoqti	65	5	AC	AC	NNP
cord-345762-khvcoqti	65	6	was	be	VBD
cord-345762-khvcoqti	65	7	only	only	RB
cord-345762-khvcoqti	65	8	3	3	CD
cord-345762-khvcoqti	65	9	days	day	NNS
cord-345762-khvcoqti	65	10	,	,	,
cord-345762-khvcoqti	65	11	which	which	WDT
cord-345762-khvcoqti	65	12	makes	make	VBZ
cord-345762-khvcoqti	65	13	such	such	PDT
cord-345762-khvcoqti	65	14	a	a	DT
cord-345762-khvcoqti	65	15	large	large	JJ
cord-345762-khvcoqti	65	16	decrease	decrease	NN
cord-345762-khvcoqti	65	17	in	in	IN
cord-345762-khvcoqti	65	18	mortality	mortality	NN
cord-345762-khvcoqti	65	19	from	from	IN
cord-345762-khvcoqti	65	20	such	such	PDT
cord-345762-khvcoqti	65	21	a	a	DT
cord-345762-khvcoqti	65	22	short	short	JJ
cord-345762-khvcoqti	65	23	exposure	exposure	NN
cord-345762-khvcoqti	65	24	to	to	IN
cord-345762-khvcoqti	65	25	the	the	DT
cord-345762-khvcoqti	65	26	drug	drug	NN
cord-345762-khvcoqti	65	27	among	among	IN
cord-345762-khvcoqti	65	28	ventilated	ventilate	VBN
cord-345762-khvcoqti	65	29	patients	patient	NNS
cord-345762-khvcoqti	65	30	implausible	implausible	JJ
cord-345762-khvcoqti	65	31	.	.	.
cord-345762-khvcoqti	66	1	The	the	DT
cord-345762-khvcoqti	66	2	authors	author	NNS
cord-345762-khvcoqti	66	3	also	also	RB
cord-345762-khvcoqti	66	4	omitted	omit	VBD
cord-345762-khvcoqti	66	5	mentioning	mention	VBG
cord-345762-khvcoqti	66	6	immortal	immortal	JJ
cord-345762-khvcoqti	66	7	time	time	NN
cord-345762-khvcoqti	66	8	bias	bias	NN
cord-345762-khvcoqti	66	9	.	.	.
cord-345762-khvcoqti	67	1	12	12	CD
cord-345762-khvcoqti	68	1	Looking	look	VBG
cord-345762-khvcoqti	68	2	at	at	IN
cord-345762-khvcoqti	68	3	the	the	DT
cord-345762-khvcoqti	68	4	survival	survival	NN
cord-345762-khvcoqti	68	5	curves	curve	NNS
cord-345762-khvcoqti	68	6	of	of	IN
cord-345762-khvcoqti	68	7	both	both	DT
cord-345762-khvcoqti	68	8	groups	group	NNS
cord-345762-khvcoqti	68	9	,	,	,
cord-345762-khvcoqti	68	10	at	at	IN
cord-345762-khvcoqti	68	11	day	day	NN
cord-345762-khvcoqti	68	12	5	5	CD
cord-345762-khvcoqti	68	13	,	,	,
cord-345762-khvcoqti	68	14	about	about	RB
cord-345762-khvcoqti	68	15	20	20	CD
cord-345762-khvcoqti	68	16	%	%	NN
cord-345762-khvcoqti	68	17	of	of	IN
cord-345762-khvcoqti	68	18	the	the	DT
cord-345762-khvcoqti	68	19	patients	patient	NNS
cord-345762-khvcoqti	68	20	in	in	IN
cord-345762-khvcoqti	68	21	the	the	DT
cord-345762-khvcoqti	68	22	non	non	JJ
cord-345762-khvcoqti	68	23	-	-	JJ
cord-345762-khvcoqti	68	24	AC	AC	NNP
cord-345762-khvcoqti	68	25	group	group	NN
cord-345762-khvcoqti	68	26	had	have	VBD
cord-345762-khvcoqti	68	27	died	die	VBN
cord-345762-khvcoqti	68	28	,	,	,
cord-345762-khvcoqti	68	29	but	but	CC
cord-345762-khvcoqti	68	30	nearly	nearly	RB
cord-345762-khvcoqti	68	31	all	all	PDT
cord-345762-khvcoqti	68	32	the	the	DT
cord-345762-khvcoqti	68	33	AC	AC	NNP
cord-345762-khvcoqti	68	34	patients	patient	NNS
cord-345762-khvcoqti	68	35	were	be	VBD
cord-345762-khvcoqti	68	36	still	still	RB
cord-345762-khvcoqti	68	37	alive	alive	JJ
cord-345762-khvcoqti	68	38	.	.	.
cord-345762-khvcoqti	69	1	But	but	CC
cord-345762-khvcoqti	69	2	to	to	TO
cord-345762-khvcoqti	69	3	receive	receive	VB
cord-345762-khvcoqti	69	4	AC	AC	NNP
cord-345762-khvcoqti	69	5	at	at	IN
cord-345762-khvcoqti	69	6	day	day	NN
cord-345762-khvcoqti	69	7	5	5	CD
cord-345762-khvcoqti	69	8	,	,	,
cord-345762-khvcoqti	69	9	the	the	DT
cord-345762-khvcoqti	69	10	patient	patient	NN
cord-345762-khvcoqti	69	11	had	have	VBD
cord-345762-khvcoqti	69	12	to	to	TO
cord-345762-khvcoqti	69	13	survive	survive	VB
cord-345762-khvcoqti	69	14	,	,	,
cord-345762-khvcoqti	69	15	or	or	CC
cord-345762-khvcoqti	69	16	be	be	VB
cord-345762-khvcoqti	69	17	'	'	``
cord-345762-khvcoqti	69	18	immortal	immortal	JJ
cord-345762-khvcoqti	69	19	'	'	''
cord-345762-khvcoqti	69	20	,	,	,
cord-345762-khvcoqti	69	21	to	to	IN
cord-345762-khvcoqti	69	22	that	that	DT
cord-345762-khvcoqti	69	23	point	point	NN
cord-345762-khvcoqti	69	24	in	in	IN
cord-345762-khvcoqti	69	25	time	time	NN
cord-345762-khvcoqti	69	26	,	,	,
cord-345762-khvcoqti	69	27	with	with	IN
cord-345762-khvcoqti	69	28	credit	credit	NN
cord-345762-khvcoqti	69	29	being	be	VBG
cord-345762-khvcoqti	69	30	given	give	VBN
cord-345762-khvcoqti	69	31	to	to	IN
cord-345762-khvcoqti	69	32	AC	AC	NNP
cord-345762-khvcoqti	69	33	for	for	IN
cord-345762-khvcoqti	69	34	those	those	DT
cord-345762-khvcoqti	69	35	5	5	CD
cord-345762-khvcoqti	69	36	days	day	NNS
cord-345762-khvcoqti	69	37	of	of	IN
cord-345762-khvcoqti	69	38	survival	survival	NN
cord-345762-khvcoqti	69	39	.	.	.
cord-345762-khvcoqti	70	1	In	in	IN
cord-345762-khvcoqti	70	2	contrast	contrast	NN
cord-345762-khvcoqti	70	3	,	,	,
cord-345762-khvcoqti	70	4	the	the	DT
cord-345762-khvcoqti	70	5	non	non	JJ
cord-345762-khvcoqti	70	6	-	-	JJ
cord-345762-khvcoqti	70	7	AC	ac	JJ
cord-345762-khvcoqti	70	8	arm	arm	NN
cord-345762-khvcoqti	70	9	includes	include	VBZ
cord-345762-khvcoqti	70	10	all	all	PDT
cord-345762-khvcoqti	70	11	the	the	DT
cord-345762-khvcoqti	70	12	patients	patient	NNS
cord-345762-khvcoqti	70	13	who	who	WP
cord-345762-khvcoqti	70	14	did	do	VBD
cord-345762-khvcoqti	70	15	not	not	RB
cord-345762-khvcoqti	70	16	live	live	VB
cord-345762-khvcoqti	70	17	long	long	RB
cord-345762-khvcoqti	70	18	enough	enough	RB
cord-345762-khvcoqti	70	19	to	to	TO
cord-345762-khvcoqti	70	20	receive	receive	VB
cord-345762-khvcoqti	70	21	AC	AC	NNP
cord-345762-khvcoqti	70	22	and	and	CC
cord-345762-khvcoqti	70	23	who	who	WP
cord-345762-khvcoqti	70	24	could	could	MD
cord-345762-khvcoqti	70	25	have	have	VB
cord-345762-khvcoqti	70	26	died	die	VBN
cord-345762-khvcoqti	70	27	any	any	DT
cord-345762-khvcoqti	70	28	time	time	NN
cord-345762-khvcoqti	70	29	during	during	IN
cord-345762-khvcoqti	70	30	their	-PRON-	PRP$
cord-345762-khvcoqti	70	31	hospitalisation	hospitalisation	NN
cord-345762-khvcoqti	70	32	,	,	,
cord-345762-khvcoqti	70	33	including	include	VBG
cord-345762-khvcoqti	70	34	on	on	IN
cord-345762-khvcoqti	70	35	day	day	NN
cord-345762-khvcoqti	70	36	1	1	CD
cord-345762-khvcoqti	70	37	,	,	,
cord-345762-khvcoqti	70	38	and	and	CC
cord-345762-khvcoqti	70	39	are	be	VBP
cord-345762-khvcoqti	70	40	thus	thus	RB
cord-345762-khvcoqti	70	41	considered	consider	VBN
cord-345762-khvcoqti	70	42	'	'	``
cord-345762-khvcoqti	70	43	mortal	mortal	JJ
cord-345762-khvcoqti	70	44	.	.	.
cord-345762-khvcoqti	70	45	'	'	''
cord-345762-khvcoqti	71	1	In	in	IN
cord-345762-khvcoqti	71	2	a	a	DT
cord-345762-khvcoqti	71	3	similar	similar	JJ
cord-345762-khvcoqti	71	4	fashion	fashion	NN
cord-345762-khvcoqti	71	5	,	,	,
cord-345762-khvcoqti	71	6	any	any	DT
cord-345762-khvcoqti	71	7	other	other	JJ
cord-345762-khvcoqti	71	8	intervention	intervention	NN
cord-345762-khvcoqti	71	9	given	give	VBN
cord-345762-khvcoqti	71	10	to	to	IN
cord-345762-khvcoqti	71	11	a	a	DT
cord-345762-khvcoqti	71	12	patient	patient	NN
cord-345762-khvcoqti	71	13	who	who	WP
cord-345762-khvcoqti	71	14	survived	survive	VBD
cord-345762-khvcoqti	71	15	to	to	IN
cord-345762-khvcoqti	71	16	day	day	NN
cord-345762-khvcoqti	71	17	5	5	CD
cord-345762-khvcoqti	71	18	,	,	,
cord-345762-khvcoqti	71	19	such	such	JJ
cord-345762-khvcoqti	71	20	as	as	IN
cord-345762-khvcoqti	71	21	a	a	DT
cord-345762-khvcoqti	71	22	garlic	garlic	NN
cord-345762-khvcoqti	71	23	necklace	necklace	NN
cord-345762-khvcoqti	71	24	,	,	,
cord-345762-khvcoqti	71	25	could	could	MD
cord-345762-khvcoqti	71	26	be	be	VB
cord-345762-khvcoqti	71	27	given	give	VBN
cord-345762-khvcoqti	71	28	credit	credit	NN
cord-345762-khvcoqti	71	29	for	for	IN
cord-345762-khvcoqti	71	30	preventing	prevent	VBG
cord-345762-khvcoqti	71	31	death	death	NN
cord-345762-khvcoqti	71	32	up	up	IN
cord-345762-khvcoqti	71	33	to	to	IN
cord-345762-khvcoqti	71	34	that	that	DT
cord-345762-khvcoqti	71	35	point	point	NN
cord-345762-khvcoqti	71	36	in	in	IN
cord-345762-khvcoqti	71	37	time	time	NN
cord-345762-khvcoqti	71	38	.	.	.
cord-345762-khvcoqti	72	1	Despite	despite	IN
cord-345762-khvcoqti	72	2	these	these	DT
cord-345762-khvcoqti	72	3	multiple	multiple	JJ
cord-345762-khvcoqti	72	4	flaws	flaw	NNS
cord-345762-khvcoqti	72	5	,	,	,
cord-345762-khvcoqti	72	6	the	the	DT
cord-345762-khvcoqti	72	7	authors	author	NNS
cord-345762-khvcoqti	72	8	concluded	conclude	VBD
cord-345762-khvcoqti	72	9	that	that	IN
cord-345762-khvcoqti	72	10	systemic	systemic	JJ
cord-345762-khvcoqti	72	11	AC	ac	NN
cord-345762-khvcoqti	72	12	may	may	MD
cord-345762-khvcoqti	72	13	be	be	VB
cord-345762-khvcoqti	72	14	associated	associate	VBN
cord-345762-khvcoqti	72	15	with	with	IN
cord-345762-khvcoqti	72	16	improved	improved	JJ
cord-345762-khvcoqti	72	17	survival	survival	NN
cord-345762-khvcoqti	72	18	after	after	IN
cord-345762-khvcoqti	72	19	adjusting	adjust	VBG
cord-345762-khvcoqti	72	20	for	for	IN
cord-345762-khvcoqti	72	21	mechanical	mechanical	JJ
cord-345762-khvcoqti	72	22	ventilation	ventilation	NN
cord-345762-khvcoqti	72	23	.	.	.
cord-345762-khvcoqti	73	1	The	the	DT
cord-345762-khvcoqti	73	2	second	second	JJ
cord-345762-khvcoqti	73	3	author	author	NN
cord-345762-khvcoqti	73	4	of	of	IN
cord-345762-khvcoqti	73	5	the	the	DT
cord-345762-khvcoqti	73	6	paper	paper	NN
cord-345762-khvcoqti	73	7	also	also	RB
cord-345762-khvcoqti	73	8	happened	happen	VBD
cord-345762-khvcoqti	73	9	to	to	TO
cord-345762-khvcoqti	73	10	be	be	VB
cord-345762-khvcoqti	73	11	the	the	DT
cord-345762-khvcoqti	73	12	editor	editor	NN
cord-345762-khvcoqti	73	13	-	-	HYPH
cord-345762-khvcoqti	73	14	in	in	IN
cord-345762-khvcoqti	73	15	-	-	HYPH
cord-345762-khvcoqti	73	16	chief	chief	NN
cord-345762-khvcoqti	73	17	of	of	IN
cord-345762-khvcoqti	73	18	the	the	DT
cord-345762-khvcoqti	73	19	journal	journal	NN
cord-345762-khvcoqti	73	20	in	in	IN
cord-345762-khvcoqti	73	21	which	which	WDT
cord-345762-khvcoqti	73	22	the	the	DT
cord-345762-khvcoqti	73	23	article	article	NN
cord-345762-khvcoqti	73	24	was	be	VBD
cord-345762-khvcoqti	73	25	published	publish	VBN
cord-345762-khvcoqti	73	26	,	,	,
cord-345762-khvcoqti	73	27	thus	thus	RB
cord-345762-khvcoqti	73	28	raising	raise	VBG
cord-345762-khvcoqti	73	29	concerns	concern	NNS
cord-345762-khvcoqti	73	30	about	about	IN
cord-345762-khvcoqti	73	31	the	the	DT
cord-345762-khvcoqti	73	32	rigour	rigour	NN
cord-345762-khvcoqti	73	33	of	of	IN
cord-345762-khvcoqti	73	34	the	the	DT
cord-345762-khvcoqti	73	35	peer	peer	NN
cord-345762-khvcoqti	73	36	review	review	NN
cord-345762-khvcoqti	73	37	process	process	NN
cord-345762-khvcoqti	73	38	.	.	.
cord-345762-khvcoqti	74	1	This	this	DT
cord-345762-khvcoqti	74	2	author	author	NN
cord-345762-khvcoqti	74	3	also	also	RB
cord-345762-khvcoqti	74	4	spoke	speak	VBD
cord-345762-khvcoqti	74	5	to	to	IN
cord-345762-khvcoqti	74	6	the	the	DT
cord-345762-khvcoqti	74	7	media	medium	NNS
cord-345762-khvcoqti	74	8	extolling	extoll	VBG
cord-345762-khvcoqti	74	9	the	the	DT
cord-345762-khvcoqti	74	10	virtues	virtue	NNS
cord-345762-khvcoqti	74	11	of	of	IN
cord-345762-khvcoqti	74	12	AC	ac	NN
cord-345762-khvcoqti	74	13	in	in	IN
cord-345762-khvcoqti	74	14	all	all	DT
cord-345762-khvcoqti	74	15	COVID-19	covid-19	CD
cord-345762-khvcoqti	74	16	patients	patient	NNS
cord-345762-khvcoqti	74	17	admitted	admit	VBN
cord-345762-khvcoqti	74	18	to	to	IN
cord-345762-khvcoqti	74	19	intensive	intensive	JJ
cord-345762-khvcoqti	74	20	care	care	NN
cord-345762-khvcoqti	74	21	and	and	CC
cord-345762-khvcoqti	74	22	announced	announce	VBD
cord-345762-khvcoqti	74	23	that	that	IN
cord-345762-khvcoqti	74	24	the	the	DT
cord-345762-khvcoqti	74	25	Mount	Mount	NNP
cord-345762-khvcoqti	74	26	Sinai	Sinai	NNP
cord-345762-khvcoqti	74	27	hospital	hospital	NN
cord-345762-khvcoqti	74	28	system	system	NN
cord-345762-khvcoqti	74	29	had	have	VBD
cord-345762-khvcoqti	74	30	changed	change	VBN
cord-345762-khvcoqti	74	31	its	-PRON-	PRP$
cord-345762-khvcoqti	74	32	protocols	protocol	NNS
cord-345762-khvcoqti	74	33	to	to	TO
cord-345762-khvcoqti	74	34	begin	begin	VB
cord-345762-khvcoqti	74	35	giving	give	VBG
cord-345762-khvcoqti	74	36	such	such	JJ
cord-345762-khvcoqti	74	37	patients	patient	NNS
cord-345762-khvcoqti	74	38	therapeutic	therapeutic	JJ
cord-345762-khvcoqti	74	39	doses	dose	NNS
cord-345762-khvcoqti	74	40	of	of	IN
cord-345762-khvcoqti	74	41	AC	AC	NNP
cord-345762-khvcoqti	74	42	.	.	.
cord-345762-khvcoqti	75	1	Multiple	multiple	JJ
cord-345762-khvcoqti	75	2	commentators	commentator	NNS
cord-345762-khvcoqti	75	3	took	take	VBD
cord-345762-khvcoqti	75	4	to	to	IN
cord-345762-khvcoqti	75	5	Twitter	Twitter	NNP
cord-345762-khvcoqti	75	6	exposing	expose	VBG
cord-345762-khvcoqti	75	7	the	the	DT
cord-345762-khvcoqti	75	8	flaws	flaw	NNS
cord-345762-khvcoqti	75	9	of	of	IN
cord-345762-khvcoqti	75	10	the	the	DT
cord-345762-khvcoqti	75	11	study	study	NN
cord-345762-khvcoqti	75	12	within	within	IN
cord-345762-khvcoqti	75	13	hours	hour	NNS
cord-345762-khvcoqti	75	14	of	of	IN
cord-345762-khvcoqti	75	15	publication	publication	NN
cord-345762-khvcoqti	75	16	,	,	,
cord-345762-khvcoqti	75	17	emphasising	emphasise	VBG
cord-345762-khvcoqti	75	18	that	that	IN
cord-345762-khvcoqti	75	19	observational	observational	JJ
cord-345762-khvcoqti	75	20	studies	study	NNS
cord-345762-khvcoqti	75	21	are	be	VBP
cord-345762-khvcoqti	75	22	prone	prone	JJ
cord-345762-khvcoqti	75	23	to	to	IN
cord-345762-khvcoqti	75	24	bias	bias	NN
cord-345762-khvcoqti	75	25	,	,	,
cord-345762-khvcoqti	75	26	often	often	RB
cord-345762-khvcoqti	75	27	report	report	VBP
cord-345762-khvcoqti	75	28	over	over	RB
cord-345762-khvcoqti	75	29	-	-	HYPH
cord-345762-khvcoqti	75	30	inflated	inflated	JJ
cord-345762-khvcoqti	75	31	effect	effect	NN
cord-345762-khvcoqti	75	32	sizes	size	NNS
cord-345762-khvcoqti	75	33	andif	andif	NNP
cord-345762-khvcoqti	75	34	adopted	adopt	VBN
cord-345762-khvcoqti	75	35	as	as	IN
cord-345762-khvcoqti	75	36	new	new	JJ
cord-345762-khvcoqti	75	37	standards	standard	NNS
cord-345762-khvcoqti	75	38	of	of	IN
cord-345762-khvcoqti	75	39	careimpede	careimpede	NNP
cord-345762-khvcoqti	75	40	the	the	DT
cord-345762-khvcoqti	75	41	ability	ability	NN
cord-345762-khvcoqti	75	42	to	to	TO
cord-345762-khvcoqti	75	43	mount	mount	VB
cord-345762-khvcoqti	75	44	robust	robust	JJ
cord-345762-khvcoqti	75	45	RCT	RCT	NNP
cord-345762-khvcoqti	75	46	capable	capable	JJ
cord-345762-khvcoqti	75	47	of	of	IN
cord-345762-khvcoqti	75	48	providing	provide	VBG
cord-345762-khvcoqti	75	49	more	more	RBR
cord-345762-khvcoqti	75	50	definitive	definitive	JJ
cord-345762-khvcoqti	75	51	results	result	NNS
cord-345762-khvcoqti	75	52	.	.	.
cord-345762-khvcoqti	76	1	Flawed	flawed	JJ
cord-345762-khvcoqti	76	2	data	datum	NNS
cord-345762-khvcoqti	76	3	can	can	MD
cord-345762-khvcoqti	76	4	be	be	VB
cord-345762-khvcoqti	76	5	worse	bad	JJR
cord-345762-khvcoqti	76	6	than	than	IN
cord-345762-khvcoqti	76	7	no	no	DT
cord-345762-khvcoqti	76	8	data	datum	NNS
cord-345762-khvcoqti	76	9	,	,	,
cord-345762-khvcoqti	76	10	and	and	CC
cord-345762-khvcoqti	76	11	observational	observational	JJ
cord-345762-khvcoqti	76	12	studies	study	NNS
cord-345762-khvcoqti	76	13	should	should	MD
cord-345762-khvcoqti	76	14	not	not	RB
cord-345762-khvcoqti	76	15	be	be	VB
cord-345762-khvcoqti	76	16	used	use	VBN
cord-345762-khvcoqti	76	17	to	to	TO
cord-345762-khvcoqti	76	18	establish	establish	VB
cord-345762-khvcoqti	76	19	a	a	DT
cord-345762-khvcoqti	76	20	new	new	JJ
cord-345762-khvcoqti	76	21	normal	normal	JJ
cord-345762-khvcoqti	76	22	.	.	.
cord-345762-khvcoqti	77	1	Internal	Internal	NNP
cord-345762-khvcoqti	77	2	Medicine	Medicine	NNP
cord-345762-khvcoqti	77	3	Journal	Journal	NNP
cord-345762-khvcoqti	77	4	50	50	CD
cord-345762-khvcoqti	77	5	(	(	-LRB-
cord-345762-khvcoqti	77	6	2020	2020	CD
cord-345762-khvcoqti	77	7	)	)	-RRB-
cord-345762-khvcoqti	78	1	904	904	CD
cord-345762-khvcoqti	78	2	-	-	SYM
cord-345762-khvcoqti	78	3	909	909	CD
cord-345762-khvcoqti	78	4	treatment	treatment	NN
cord-345762-khvcoqti	78	5	groups	group	NNS
cord-345762-khvcoqti	78	6	,	,	,
cord-345762-khvcoqti	78	7	from	from	IN
cord-345762-khvcoqti	78	8	a	a	DT
cord-345762-khvcoqti	78	9	patient	patient	NN
cord-345762-khvcoqti	78	10	's	's	POS
cord-345762-khvcoqti	78	11	perspective	perspective	NN
cord-345762-khvcoqti	78	12	,	,	,
cord-345762-khvcoqti	78	13	has	have	VBZ
cord-345762-khvcoqti	78	14	been	be	VBN
cord-345762-khvcoqti	78	15	determined	determine	VBN
cord-345762-khvcoqti	78	16	.	.	.
cord-345762-khvcoqti	79	1	33	33	CD
cord-345762-khvcoqti	80	1	This	this	DT
cord-345762-khvcoqti	80	2	would	would	MD
cord-345762-khvcoqti	80	3	allow	allow	VB
cord-345762-khvcoqti	80	4	for	for	IN
cord-345762-khvcoqti	80	5	additional	additional	JJ
cord-345762-khvcoqti	80	6	analyses	analysis	NNS
cord-345762-khvcoqti	80	7	,	,	,
cord-345762-khvcoqti	80	8	even	even	RB
cord-345762-khvcoqti	80	9	if	if	IN
cord-345762-khvcoqti	80	10	the	the	DT
cord-345762-khvcoqti	80	11	analyses	analysis	NNS
cord-345762-khvcoqti	80	12	of	of	IN
cord-345762-khvcoqti	80	13	the	the	DT
cord-345762-khvcoqti	80	14	combined	combine	VBN
cord-345762-khvcoqti	80	15	data	datum	NNS
cord-345762-khvcoqti	80	16	were	be	VBD
cord-345762-khvcoqti	80	17	not	not	RB
cord-345762-khvcoqti	80	18	preplanned	preplanne	VBN
cord-345762-khvcoqti	80	19	,	,	,
cord-345762-khvcoqti	80	20	and	and	CC
cord-345762-khvcoqti	80	21	would	would	MD
cord-345762-khvcoqti	80	22	be	be	VB
cord-345762-khvcoqti	80	23	considered	consider	VBN
cord-345762-khvcoqti	80	24	exploratory	exploratory	JJ
cord-345762-khvcoqti	80	25	.	.	.
cord-345762-khvcoqti	81	1	The	the	DT
cord-345762-khvcoqti	81	2	goal	goal	NN
cord-345762-khvcoqti	81	3	is	be	VBZ
cord-345762-khvcoqti	81	4	to	to	TO
cord-345762-khvcoqti	81	5	expand	expand	VB
cord-345762-khvcoqti	81	6	what	what	WP
cord-345762-khvcoqti	81	7	is	be	VBZ
cord-345762-khvcoqti	81	8	known	know	VBN
cord-345762-khvcoqti	81	9	about	about	IN
cord-345762-khvcoqti	81	10	possible	possible	JJ
cord-345762-khvcoqti	81	11	treatments	treatment	NNS
cord-345762-khvcoqti	81	12	so	so	IN
cord-345762-khvcoqti	81	13	that	that	IN
cord-345762-khvcoqti	81	14	future	future	JJ
cord-345762-khvcoqti	81	15	trials	trial	NNS
cord-345762-khvcoqti	81	16	can	can	MD
cord-345762-khvcoqti	81	17	be	be	VB
cord-345762-khvcoqti	81	18	improved	improve	VBN
cord-345762-khvcoqti	81	19	using	use	VBG
cord-345762-khvcoqti	81	20	the	the	DT
cord-345762-khvcoqti	81	21	adaptive	adaptive	JJ
cord-345762-khvcoqti	81	22	designs	design	NNS
cord-345762-khvcoqti	81	23	already	already	RB
cord-345762-khvcoqti	81	24	mentioned	mention	VBN
cord-345762-khvcoqti	81	25	.	.	.
cord-345762-khvcoqti	82	1	Fourth	fourth	RB
cord-345762-khvcoqti	82	2	,	,	,
cord-345762-khvcoqti	82	3	funding	funding	NN
cord-345762-khvcoqti	82	4	agencies	agency	NNS
cord-345762-khvcoqti	82	5	responsible	responsible	JJ
cord-345762-khvcoqti	82	6	to	to	IN
cord-345762-khvcoqti	82	7	taxpayers	taxpayer	NNS
cord-345762-khvcoqti	82	8	need	need	VBP
cord-345762-khvcoqti	82	9	the	the	DT
cord-345762-khvcoqti	82	10	political	political	JJ
cord-345762-khvcoqti	82	11	cover	cover	NN
cord-345762-khvcoqti	82	12	and	and	CC
cord-345762-khvcoqti	82	13	authority	authority	NN
cord-345762-khvcoqti	82	14	to	to	TO
cord-345762-khvcoqti	82	15	support	support	VB
cord-345762-khvcoqti	82	16	international	international	JJ
cord-345762-khvcoqti	82	17	studies	study	NNS
cord-345762-khvcoqti	82	18	;	;	,
cord-345762-khvcoqti	82	19	pharmaceutical	pharmaceutical	NN
cord-345762-khvcoqti	82	20	companies	company	NNS
cord-345762-khvcoqti	82	21	need	need	VBP
cord-345762-khvcoqti	82	22	support	support	NN
cord-345762-khvcoqti	82	23	and	and	CC
cord-345762-khvcoqti	82	24	incentives	incentive	NNS
cord-345762-khvcoqti	82	25	from	from	IN
cord-345762-khvcoqti	82	26	regulatory	regulatory	JJ
cord-345762-khvcoqti	82	27	authorities	authority	NNS
cord-345762-khvcoqti	82	28	to	to	TO
cord-345762-khvcoqti	82	29	participate	participate	VB
cord-345762-khvcoqti	82	30	in	in	IN
cord-345762-khvcoqti	82	31	collaborative	collaborative	JJ
cord-345762-khvcoqti	82	32	trials	trial	NNS
cord-345762-khvcoqti	82	33	;	;	:
cord-345762-khvcoqti	82	34	and	and	CC
cord-345762-khvcoqti	82	35	academic	academic	JJ
cord-345762-khvcoqti	82	36	investigators	investigator	NNS
cord-345762-khvcoqti	82	37	need	need	VBP
cord-345762-khvcoqti	82	38	a	a	DT
cord-345762-khvcoqti	82	39	structure	structure	NN
cord-345762-khvcoqti	82	40	that	that	WDT
cord-345762-khvcoqti	82	41	provides	provide	VBZ
cord-345762-khvcoqti	82	42	academic	academic	JJ
cord-345762-khvcoqti	82	43	credit	credit	NN
cord-345762-khvcoqti	82	44	and	and	CC
cord-345762-khvcoqti	82	45	incentive	incentive	NN
cord-345762-khvcoqti	82	46	to	to	TO
cord-345762-khvcoqti	82	47	collaborate	collaborate	VB
cord-345762-khvcoqti	82	48	in	in	IN
cord-345762-khvcoqti	82	49	efforts	effort	NNS
cord-345762-khvcoqti	82	50	where	where	WRB
cord-345762-khvcoqti	82	51	they	-PRON-	PRP
cord-345762-khvcoqti	82	52	might	may	MD
cord-345762-khvcoqti	82	53	otherwise	otherwise	RB
cord-345762-khvcoqti	82	54	perceive	perceive	VB
cord-345762-khvcoqti	82	55	anonymity	anonymity	NN
cord-345762-khvcoqti	82	56	and	and	CC
cord-345762-khvcoqti	82	57	loss	loss	NN
cord-345762-khvcoqti	82	58	of	of	IN
cord-345762-khvcoqti	82	59	control	control	NN
cord-345762-khvcoqti	82	60	and	and	CC
cord-345762-khvcoqti	82	61	intellectual	intellectual	JJ
cord-345762-khvcoqti	82	62	property	property	NN
cord-345762-khvcoqti	82	63	.	.	.
cord-345762-khvcoqti	83	1	An	an	DT
cord-345762-khvcoqti	83	2	example	example	NN
cord-345762-khvcoqti	83	3	of	of	IN
cord-345762-khvcoqti	83	4	such	such	JJ
cord-345762-khvcoqti	83	5	multi	multi	JJ
cord-345762-khvcoqti	83	6	-	-	JJ
cord-345762-khvcoqti	83	7	sectoral	sectoral	JJ
cord-345762-khvcoqti	83	8	collaboration	collaboration	NN
cord-345762-khvcoqti	83	9	is	be	VBZ
cord-345762-khvcoqti	83	10	the	the	DT
cord-345762-khvcoqti	83	11	recently	recently	RB
cord-345762-khvcoqti	83	12	announced	announce	VBN
cord-345762-khvcoqti	83	13	Accelerating	Accelerating	NNP
cord-345762-khvcoqti	83	14	COVID-19	COVID-19	NNP
cord-345762-khvcoqti	83	15	Therapeutic	Therapeutic	NNP
cord-345762-khvcoqti	83	16	Interventions	Interventions	NNPS
cord-345762-khvcoqti	83	17	and	and	CC
cord-345762-khvcoqti	83	18	Vaccines	Vaccines	NNPS
cord-345762-khvcoqti	83	19	(	(	-LRB-
cord-345762-khvcoqti	83	20	ACTIV	ACTIV	NNP
cord-345762-khvcoqti	83	21	)	)	-RRB-
cord-345762-khvcoqti	83	22	partnership	partnership	NN
cord-345762-khvcoqti	83	23	in	in	IN
cord-345762-khvcoqti	83	24	the	the	DT
cord-345762-khvcoqti	83	25	United	United	NNP
cord-345762-khvcoqti	83	26	States	States	NNP
cord-345762-khvcoqti	83	27	34	34	CD
cord-345762-khvcoqti	83	28	whose	whose	WP$
cord-345762-khvcoqti	83	29	industry	industry	NN
cord-345762-khvcoqti	83	30	partners	partner	NNS
cord-345762-khvcoqti	83	31	agree	agree	VBP
cord-345762-khvcoqti	83	32	to	to	TO
cord-345762-khvcoqti	83	33	support	support	VB
cord-345762-khvcoqti	83	34	the	the	DT
cord-345762-khvcoqti	83	35	prioritisation	prioritisation	NN
cord-345762-khvcoqti	83	36	of	of	IN
cord-345762-khvcoqti	83	37	therapeutic	therapeutic	JJ
cord-345762-khvcoqti	83	38	and	and	CC
cord-345762-khvcoqti	83	39	vaccine	vaccine	NN
cord-345762-khvcoqti	83	40	candidates	candidate	NNS
cord-345762-khvcoqti	83	41	,	,	,
cord-345762-khvcoqti	83	42	no	no	RB
cord-345762-khvcoqti	83	43	matter	matter	RB
cord-345762-khvcoqti	83	44	who	who	WP
cord-345762-khvcoqti	83	45	has	have	VBZ
cord-345762-khvcoqti	83	46	developed	develop	VBN
cord-345762-khvcoqti	83	47	them	-PRON-	PRP
cord-345762-khvcoqti	83	48	,	,	,
cord-345762-khvcoqti	83	49	and	and	CC
cord-345762-khvcoqti	83	50	to	to	TO
cord-345762-khvcoqti	83	51	share	share	VB
cord-345762-khvcoqti	83	52	their	-PRON-	PRP$
cord-345762-khvcoqti	83	53	respective	respective	JJ
cord-345762-khvcoqti	83	54	clinical	clinical	JJ
cord-345762-khvcoqti	83	55	trial	trial	NN
cord-345762-khvcoqti	83	56	capacities	capacity	NNS
cord-345762-khvcoqti	83	57	,	,	,
cord-345762-khvcoqti	83	58	irrespective	irrespective	RB
cord-345762-khvcoqti	83	59	of	of	IN
cord-345762-khvcoqti	83	60	the	the	DT
cord-345762-khvcoqti	83	61	agent	agent	NN
cord-345762-khvcoqti	83	62	to	to	TO
cord-345762-khvcoqti	83	63	be	be	VB
cord-345762-khvcoqti	83	64	studied	study	VBN
cord-345762-khvcoqti	83	65	.	.	.
cord-345762-khvcoqti	84	1	For	for	IN
cord-345762-khvcoqti	84	2	their	-PRON-	PRP$
cord-345762-khvcoqti	84	3	part	part	NN
cord-345762-khvcoqti	84	4	,	,	,
cord-345762-khvcoqti	84	5	the	the	DT
cord-345762-khvcoqti	84	6	public	public	JJ
cord-345762-khvcoqti	84	7	partners	partner	NNS
cord-345762-khvcoqti	84	8	led	lead	VBN
cord-345762-khvcoqti	84	9	by	by	IN
cord-345762-khvcoqti	84	10	the	the	DT
cord-345762-khvcoqti	84	11	National	National	NNP
cord-345762-khvcoqti	84	12	Institutes	Institutes	NNPS
cord-345762-khvcoqti	84	13	of	of	IN
cord-345762-khvcoqti	84	14	Health	Health	NNP
cord-345762-khvcoqti	84	15	resolve	resolve	VBP
cord-345762-khvcoqti	84	16	to	to	TO
cord-345762-khvcoqti	84	17	streamline	streamline	VB
cord-345762-khvcoqti	84	18	research	research	NN
cord-345762-khvcoqti	84	19	and	and	CC
cord-345762-khvcoqti	84	20	regulatory	regulatory	JJ
cord-345762-khvcoqti	84	21	issues	issue	NNS
cord-345762-khvcoqti	84	22	to	to	TO
cord-345762-khvcoqti	84	23	drive	drive	VB
cord-345762-khvcoqti	84	24	expedited	expedited	JJ
cord-345762-khvcoqti	84	25	evaluation	evaluation	NN
cord-345762-khvcoqti	84	26	and	and	CC
cord-345762-khvcoqti	84	27	rapid	rapid	JJ
cord-345762-khvcoqti	84	28	scale	scale	NN
cord-345762-khvcoqti	84	29	-	-	HYPH
cord-345762-khvcoqti	84	30	up	up	NN
cord-345762-khvcoqti	84	31	and	and	CC
cord-345762-khvcoqti	84	32	manufacturing	manufacturing	NN
cord-345762-khvcoqti	84	33	of	of	IN
cord-345762-khvcoqti	84	34	candidate	candidate	NN
cord-345762-khvcoqti	84	35	therapies	therapy	NNS
cord-345762-khvcoqti	84	36	with	with	IN
cord-345762-khvcoqti	84	37	predicted	predict	VBN
cord-345762-khvcoqti	84	38	successful	successful	JJ
cord-345762-khvcoqti	84	39	outcomes	outcome	NNS
cord-345762-khvcoqti	84	40	.	.	.
cord-345762-khvcoqti	85	1	Finally	finally	RB
cord-345762-khvcoqti	85	2	,	,	,
cord-345762-khvcoqti	85	3	every	every	DT
cord-345762-khvcoqti	85	4	clinician	clinician	NN
cord-345762-khvcoqti	85	5	involved	involve	VBN
cord-345762-khvcoqti	85	6	in	in	IN
cord-345762-khvcoqti	85	7	managing	manage	VBG
cord-345762-khvcoqti	85	8	COVID-19	covid-19	CD
cord-345762-khvcoqti	85	9	patients	patient	NNS
cord-345762-khvcoqti	85	10	must	must	MD
cord-345762-khvcoqti	85	11	commit	commit	VB
cord-345762-khvcoqti	85	12	to	to	IN
cord-345762-khvcoqti	85	13	acknowledging	acknowledge	VBG
cord-345762-khvcoqti	85	14	equipoise	equipoise	NN
cord-345762-khvcoqti	85	15	and	and	CC
cord-345762-khvcoqti	85	16	Box	Box	NNP
cord-345762-khvcoqti	85	17	2	2	CD
cord-345762-khvcoqti	85	18	Rapidly	rapidly	RB
cord-345762-khvcoqti	85	19	cycling	cycle	VBG
cord-345762-khvcoqti	85	20	trial	trial	NN
cord-345762-khvcoqti	85	21	designs	design	NNS
cord-345762-khvcoqti	85	22	Adaptive	adaptive	JJ
cord-345762-khvcoqti	85	23	randomisation	randomisation	NN
cord-345762-khvcoqti	86	1	Adaptive	adaptive	JJ
cord-345762-khvcoqti	86	2	trials	trial	NNS
cord-345762-khvcoqti	86	3	allow	allow	VBP
cord-345762-khvcoqti	86	4	pre	pre	JJ
cord-345762-khvcoqti	86	5	-	-	JJ
cord-345762-khvcoqti	86	6	specified	specified	JJ
cord-345762-khvcoqti	86	7	changes	change	NNS
cord-345762-khvcoqti	86	8	in	in	IN
cord-345762-khvcoqti	86	9	key	key	JJ
cord-345762-khvcoqti	86	10	trial	trial	NN
cord-345762-khvcoqti	86	11	characteristics	characteristic	NNS
cord-345762-khvcoqti	86	12	while	while	IN
cord-345762-khvcoqti	86	13	it	-PRON-	PRP
cord-345762-khvcoqti	86	14	is	be	VBZ
cord-345762-khvcoqti	86	15	being	be	VBG
cord-345762-khvcoqti	86	16	conducted	conduct	VBN
cord-345762-khvcoqti	86	17	in	in	IN
cord-345762-khvcoqti	86	18	response	response	NN
cord-345762-khvcoqti	86	19	to	to	IN
cord-345762-khvcoqti	86	20	information	information	NN
cord-345762-khvcoqti	86	21	accumulating	accumulate	VBG
cord-345762-khvcoqti	86	22	during	during	IN
cord-345762-khvcoqti	86	23	the	the	DT
cord-345762-khvcoqti	86	24	trial	trial	NN
cord-345762-khvcoqti	86	25	.	.	.
cord-345762-khvcoqti	87	1	25	25	CD
cord-345762-khvcoqti	87	2	Adaptive	adaptive	JJ
cord-345762-khvcoqti	87	3	randomisation	randomisation	NN
cord-345762-khvcoqti	87	4	(	(	-LRB-
cord-345762-khvcoqti	87	5	AR	AR	NNP
cord-345762-khvcoqti	87	6	)	)	-RRB-
cord-345762-khvcoqti	87	7	allows	allow	VBZ
cord-345762-khvcoqti	87	8	changes	change	NNS
cord-345762-khvcoqti	87	9	to	to	TO
cord-345762-khvcoqti	87	10	be	be	VB
cord-345762-khvcoqti	87	11	made	make	VBN
cord-345762-khvcoqti	87	12	to	to	IN
cord-345762-khvcoqti	87	13	the	the	DT
cord-345762-khvcoqti	87	14	probabilities	probability	NNS
cord-345762-khvcoqti	87	15	of	of	IN
cord-345762-khvcoqti	87	16	participants	participant	NNS
cord-345762-khvcoqti	87	17	being	be	VBG
cord-345762-khvcoqti	87	18	randomised	randomise	VBN
cord-345762-khvcoqti	87	19	to	to	IN
cord-345762-khvcoqti	87	20	one	one	CD
cord-345762-khvcoqti	87	21	treatment	treatment	NN
cord-345762-khvcoqti	87	22	(	(	-LRB-
cord-345762-khvcoqti	87	23	or	or	CC
cord-345762-khvcoqti	87	24	treatment	treatment	NN
cord-345762-khvcoqti	87	25	combination	combination	NN
cord-345762-khvcoqti	87	26	)	)	-RRB-
cord-345762-khvcoqti	87	27	versus	versus	IN
cord-345762-khvcoqti	87	28	another	another	DT
cord-345762-khvcoqti	87	29	during	during	IN
cord-345762-khvcoqti	87	30	the	the	DT
cord-345762-khvcoqti	87	31	trial	trial	NN
cord-345762-khvcoqti	87	32	with	with	IN
cord-345762-khvcoqti	87	33	the	the	DT
cord-345762-khvcoqti	87	34	aim	aim	NN
cord-345762-khvcoqti	87	35	of	of	IN
cord-345762-khvcoqti	87	36	allocating	allocate	VBG
cord-345762-khvcoqti	87	37	a	a	DT
cord-345762-khvcoqti	87	38	greater	great	JJR
cord-345762-khvcoqti	87	39	proportion	proportion	NN
cord-345762-khvcoqti	87	40	of	of	IN
cord-345762-khvcoqti	87	41	patients	patient	NNS
cord-345762-khvcoqti	87	42	to	to	IN
cord-345762-khvcoqti	87	43	treatments	treatment	NNS
cord-345762-khvcoqti	87	44	that	that	WDT
cord-345762-khvcoqti	87	45	are	be	VBP
cord-345762-khvcoqti	87	46	demonstrating	demonstrate	VBG
cord-345762-khvcoqti	87	47	evidence	evidence	NN
cord-345762-khvcoqti	87	48	of	of	IN
cord-345762-khvcoqti	87	49	better	well	JJR
cord-345762-khvcoqti	87	50	performance	performance	NN
cord-345762-khvcoqti	87	51	than	than	IN
cord-345762-khvcoqti	87	52	others	other	NNS
cord-345762-khvcoqti	87	53	.	.	.
cord-345762-khvcoqti	88	1	This	this	DT
cord-345762-khvcoqti	88	2	evidence	evidence	NN
cord-345762-khvcoqti	88	3	of	of	IN
cord-345762-khvcoqti	88	4	better	well	JJR
cord-345762-khvcoqti	88	5	performance	performance	NN
cord-345762-khvcoqti	88	6	can	can	MD
cord-345762-khvcoqti	88	7	comprise	comprise	VB
cord-345762-khvcoqti	88	8	information	information	NN
cord-345762-khvcoqti	88	9	from	from	IN
cord-345762-khvcoqti	88	10	the	the	DT
cord-345762-khvcoqti	88	11	trial	trial	NN
cord-345762-khvcoqti	88	12	itself	-PRON-	PRP
cord-345762-khvcoqti	88	13	,	,	,
cord-345762-khvcoqti	88	14	evidence	evidence	NN
cord-345762-khvcoqti	88	15	emanating	emanate	VBG
cord-345762-khvcoqti	88	16	from	from	IN
cord-345762-khvcoqti	88	17	other	other	JJ
cord-345762-khvcoqti	88	18	trials	trial	NNS
cord-345762-khvcoqti	88	19	and	and	CC
cord-345762-khvcoqti	88	20	expert	expert	JJ
cord-345762-khvcoqti	88	21	opinion	opinion	NN
cord-345762-khvcoqti	88	22	from	from	IN
cord-345762-khvcoqti	88	23	multiple	multiple	JJ
cord-345762-khvcoqti	88	24	groups	group	NNS
cord-345762-khvcoqti	88	25	or	or	CC
cord-345762-khvcoqti	88	26	societies	society	NNS
cord-345762-khvcoqti	88	27	.	.	.
cord-345762-khvcoqti	89	1	Bayesian	bayesian	JJ
cord-345762-khvcoqti	89	2	statistical	statistical	JJ
cord-345762-khvcoqti	89	3	methods	method	NNS
cord-345762-khvcoqti	89	4	are	be	VBP
cord-345762-khvcoqti	89	5	used	use	VBN
cord-345762-khvcoqti	89	6	to	to	TO
cord-345762-khvcoqti	89	7	continually	continually	RB
cord-345762-khvcoqti	89	8	update	update	VB
cord-345762-khvcoqti	89	9	trials	trial	NNS
cord-345762-khvcoqti	89	10	with	with	IN
cord-345762-khvcoqti	89	11	new	new	JJ
cord-345762-khvcoqti	89	12	information	information	NN
cord-345762-khvcoqti	89	13	as	as	IN
cord-345762-khvcoqti	89	14	it	-PRON-	PRP
cord-345762-khvcoqti	89	15	becomes	become	VBZ
cord-345762-khvcoqti	89	16	available	available	JJ
cord-345762-khvcoqti	89	17	while	while	IN
cord-345762-khvcoqti	89	18	at	at	IN
cord-345762-khvcoqti	89	19	the	the	DT
cord-345762-khvcoqti	89	20	same	same	JJ
cord-345762-khvcoqti	89	21	time	time	NN
cord-345762-khvcoqti	89	22	maintaining	maintain	VBG
cord-345762-khvcoqti	89	23	trial	trial	NN
cord-345762-khvcoqti	89	24	integrity	integrity	NN
cord-345762-khvcoqti	89	25	,	,	,
cord-345762-khvcoqti	89	26	thus	thus	RB
cord-345762-khvcoqti	89	27	allowing	allow	VBG
cord-345762-khvcoqti	89	28	trials	trial	NNS
cord-345762-khvcoqti	89	29	to	to	TO
cord-345762-khvcoqti	89	30	'	'	''
cord-345762-khvcoqti	89	31	learn	learn	VB
cord-345762-khvcoqti	89	32	as	as	IN
cord-345762-khvcoqti	89	33	they	-PRON-	PRP
cord-345762-khvcoqti	89	34	go	go	VBP
cord-345762-khvcoqti	89	35	'	'	''
cord-345762-khvcoqti	89	36	.	.	.
cord-345762-khvcoqti	90	1	This	this	DT
cord-345762-khvcoqti	90	2	level	level	NN
cord-345762-khvcoqti	90	3	of	of	IN
cord-345762-khvcoqti	90	4	flexibility	flexibility	NN
cord-345762-khvcoqti	90	5	is	be	VBZ
cord-345762-khvcoqti	90	6	difficult	difficult	JJ
cord-345762-khvcoqti	90	7	with	with	IN
cord-345762-khvcoqti	90	8	classical	classical	JJ
cord-345762-khvcoqti	90	9	,	,	,
cord-345762-khvcoqti	90	10	non	non	JJ
cord-345762-khvcoqti	90	11	-	-	JJ
cord-345762-khvcoqti	90	12	Bayesian	bayesian	JJ
cord-345762-khvcoqti	90	13	approaches	approach	NNS
cord-345762-khvcoqti	90	14	that	that	WDT
cord-345762-khvcoqti	90	15	have	have	VBP
cord-345762-khvcoqti	90	16	a	a	DT
cord-345762-khvcoqti	90	17	less	less	RBR
cord-345762-khvcoqti	90	18	informative	informative	JJ
cord-345762-khvcoqti	90	19	focus	focus	NN
cord-345762-khvcoqti	90	20	on	on	IN
cord-345762-khvcoqti	90	21	what	what	WP
cord-345762-khvcoqti	90	22	'	'	``
cord-345762-khvcoqti	90	23	works	work	NNS
cord-345762-khvcoqti	90	24	'	'	''
cord-345762-khvcoqti	90	25	or	or	CC
cord-345762-khvcoqti	90	26	'	'	``
cord-345762-khvcoqti	90	27	does	do	VBZ
cord-345762-khvcoqti	90	28	n't	not	RB
cord-345762-khvcoqti	90	29	work	work	VB
cord-345762-khvcoqti	90	30	'	'	''
cord-345762-khvcoqti	90	31	according	accord	VBG
cord-345762-khvcoqti	90	32	to	to	IN
cord-345762-khvcoqti	90	33	a	a	DT
cord-345762-khvcoqti	90	34	statistical	statistical	JJ
cord-345762-khvcoqti	90	35	test	test	NN
cord-345762-khvcoqti	90	36	.	.	.
cord-345762-khvcoqti	91	1	The	the	DT
cord-345762-khvcoqti	91	2	Bayesian	bayesian	JJ
cord-345762-khvcoqti	91	3	approach	approach	NN
cord-345762-khvcoqti	91	4	is	be	VBZ
cord-345762-khvcoqti	91	5	to	to	TO
cord-345762-khvcoqti	91	6	define	define	VB
cord-345762-khvcoqti	91	7	and	and	CC
cord-345762-khvcoqti	91	8	recursively	recursively	RB
cord-345762-khvcoqti	91	9	update	update	VB
cord-345762-khvcoqti	91	10	the	the	DT
cord-345762-khvcoqti	91	11	probability	probability	NN
cord-345762-khvcoqti	91	12	that	that	IN
cord-345762-khvcoqti	91	13	a	a	DT
cord-345762-khvcoqti	91	14	treatment	treatment	NN
cord-345762-khvcoqti	91	15	works	work	VBZ
cord-345762-khvcoqti	91	16	based	base	VBN
cord-345762-khvcoqti	91	17	on	on	IN
cord-345762-khvcoqti	91	18	combining	combine	VBG
cord-345762-khvcoqti	91	19	information	information	NN
cord-345762-khvcoqti	91	20	more	more	RBR
cord-345762-khvcoqti	91	21	naturally	naturally	RB
cord-345762-khvcoqti	91	22	,	,	,
cord-345762-khvcoqti	91	23	better	well	RBR
cord-345762-khvcoqti	91	24	resembling	resemble	VBG
cord-345762-khvcoqti	91	25	how	how	WRB
cord-345762-khvcoqti	91	26	clinicians	clinician	NNS
cord-345762-khvcoqti	91	27	think	think	VBP
cord-345762-khvcoqti	91	28	in	in	IN
cord-345762-khvcoqti	91	29	the	the	DT
cord-345762-khvcoqti	91	30	real	real	JJ
cord-345762-khvcoqti	91	31	world	world	NN
cord-345762-khvcoqti	91	32	.	.	.
cord-345762-khvcoqti	92	1	Non	non	JJ
cord-345762-khvcoqti	92	2	-	-	JJ
cord-345762-khvcoqti	92	3	Bayesian	bayesian	JJ
cord-345762-khvcoqti	92	4	trials	trial	NNS
cord-345762-khvcoqti	92	5	struggle	struggle	VBP
cord-345762-khvcoqti	92	6	to	to	TO
cord-345762-khvcoqti	92	7	confirm	confirm	VB
cord-345762-khvcoqti	92	8	whether	whether	IN
cord-345762-khvcoqti	92	9	a	a	DT
cord-345762-khvcoqti	92	10	treatment	treatment	NN
cord-345762-khvcoqti	92	11	works	work	VBZ
cord-345762-khvcoqti	92	12	under	under	IN
cord-345762-khvcoqti	92	13	uncertainty	uncertainty	NN
cord-345762-khvcoqti	92	14	because	because	IN
cord-345762-khvcoqti	92	15	the	the	DT
cord-345762-khvcoqti	92	16	sample	sample	NN
cord-345762-khvcoqti	92	17	size	size	NN
cord-345762-khvcoqti	92	18	and	and	CC
cord-345762-khvcoqti	92	19	design	design	NN
cord-345762-khvcoqti	92	20	features	feature	NNS
cord-345762-khvcoqti	92	21	of	of	IN
cord-345762-khvcoqti	92	22	the	the	DT
cord-345762-khvcoqti	92	23	trial	trial	NN
cord-345762-khvcoqti	92	24	rely	rely	VBP
cord-345762-khvcoqti	92	25	on	on	IN
cord-345762-khvcoqti	92	26	assumptions	assumption	NNS
cord-345762-khvcoqti	92	27	about	about	IN
cord-345762-khvcoqti	92	28	how	how	WRB
cord-345762-khvcoqti	92	29	the	the	DT
cord-345762-khvcoqti	92	30	treatment	treatment	NN
cord-345762-khvcoqti	92	31	will	will	MD
cord-345762-khvcoqti	92	32	work	work	VB
cord-345762-khvcoqti	92	33	.	.	.
cord-345762-khvcoqti	93	1	The	the	DT
cord-345762-khvcoqti	93	2	trial	trial	NN
cord-345762-khvcoqti	93	3	design	design	NN
cord-345762-khvcoqti	93	4	can	can	MD
cord-345762-khvcoqti	93	5	not	not	RB
cord-345762-khvcoqti	93	6	be	be	VB
cord-345762-khvcoqti	93	7	modified	modify	VBN
cord-345762-khvcoqti	93	8	easily	easily	RB
cord-345762-khvcoqti	93	9	,	,	,
cord-345762-khvcoqti	93	10	so	so	CC
cord-345762-khvcoqti	93	11	if	if	IN
cord-345762-khvcoqti	93	12	those	those	DT
cord-345762-khvcoqti	93	13	assumptions	assumption	NNS
cord-345762-khvcoqti	93	14	,	,	,
cord-345762-khvcoqti	93	15	including	include	VBG
cord-345762-khvcoqti	93	16	sample	sample	NN
cord-345762-khvcoqti	93	17	size	size	NN
cord-345762-khvcoqti	93	18	calculations	calculation	NNS
cord-345762-khvcoqti	93	19	,	,	,
cord-345762-khvcoqti	93	20	are	be	VBP
cord-345762-khvcoqti	93	21	ultimately	ultimately	RB
cord-345762-khvcoqti	93	22	incorrect	incorrect	JJ
cord-345762-khvcoqti	93	23	,	,	,
cord-345762-khvcoqti	93	24	the	the	DT
cord-345762-khvcoqti	93	25	trial	trial	NN
cord-345762-khvcoqti	93	26	may	may	MD
cord-345762-khvcoqti	93	27	finish	finish	VB
cord-345762-khvcoqti	93	28	without	without	IN
cord-345762-khvcoqti	93	29	providing	provide	VBG
cord-345762-khvcoqti	93	30	any	any	DT
cord-345762-khvcoqti	93	31	useful	useful	JJ
cord-345762-khvcoqti	93	32	evidence	evidence	NN
cord-345762-khvcoqti	93	33	about	about	IN
cord-345762-khvcoqti	93	34	what	what	WDT
cord-345762-khvcoqti	93	35	treatments	treatment	NNS
cord-345762-khvcoqti	93	36	are	be	VBP
cord-345762-khvcoqti	93	37	effective	effective	JJ
cord-345762-khvcoqti	93	38	.	.	.
cord-345762-khvcoqti	94	1	A	a	DT
cord-345762-khvcoqti	94	2	Bayesian	bayesian	JJ
cord-345762-khvcoqti	94	3	adaptive	adaptive	JJ
cord-345762-khvcoqti	94	4	trial	trial	NN
cord-345762-khvcoqti	94	5	can	can	MD
cord-345762-khvcoqti	94	6	swiftly	swiftly	RB
cord-345762-khvcoqti	94	7	and	and	CC
cord-345762-khvcoqti	94	8	more	more	RBR
cord-345762-khvcoqti	94	9	efficiently	efficiently	RB
cord-345762-khvcoqti	94	10	learn	learn	VB
cord-345762-khvcoqti	94	11	about	about	IN
cord-345762-khvcoqti	94	12	existing	exist	VBG
cord-345762-khvcoqti	94	13	treatments	treatment	NNS
cord-345762-khvcoqti	94	14	,	,	,
cord-345762-khvcoqti	94	15	abandon	abandon	VB
cord-345762-khvcoqti	94	16	any	any	DT
cord-345762-khvcoqti	94	17	that	that	WDT
cord-345762-khvcoqti	94	18	prove	prove	VBP
cord-345762-khvcoqti	94	19	futile	futile	JJ
cord-345762-khvcoqti	94	20	and	and	CC
cord-345762-khvcoqti	94	21	expand	expand	VBP
cord-345762-khvcoqti	94	22	to	to	TO
cord-345762-khvcoqti	94	23	include	include	VB
cord-345762-khvcoqti	94	24	new	new	JJ
cord-345762-khvcoqti	94	25	and	and	CC
cord-345762-khvcoqti	94	26	promising	promising	JJ
cord-345762-khvcoqti	94	27	candidates	candidate	NNS
cord-345762-khvcoqti	94	28	.	.	.
cord-345762-khvcoqti	95	1	26	26	CD
cord-345762-khvcoqti	96	1	It	-PRON-	PRP
cord-345762-khvcoqti	96	2	has	have	VBZ
cord-345762-khvcoqti	96	3	all	all	PDT
cord-345762-khvcoqti	96	4	the	the	DT
cord-345762-khvcoqti	96	5	advantages	advantage	NNS
cord-345762-khvcoqti	96	6	of	of	IN
cord-345762-khvcoqti	96	7	classic	classic	JJ
cord-345762-khvcoqti	96	8	group	group	NN
cord-345762-khvcoqti	96	9	sequential	sequential	JJ
cord-345762-khvcoqti	96	10	designs	design	NNS
cord-345762-khvcoqti	96	11	but	but	CC
cord-345762-khvcoqti	96	12	can	can	MD
cord-345762-khvcoqti	96	13	also	also	RB
cord-345762-khvcoqti	96	14	alter	alter	VB
cord-345762-khvcoqti	96	15	maximum	maximum	JJ
cord-345762-khvcoqti	96	16	sample	sample	NN
cord-345762-khvcoqti	96	17	size	size	NN
cord-345762-khvcoqti	96	18	,	,	,
cord-345762-khvcoqti	96	19	switch	switch	VB
cord-345762-khvcoqti	96	20	end	end	NN
cord-345762-khvcoqti	96	21	-	-	HYPH
cord-345762-khvcoqti	96	22	point	point	NN
cord-345762-khvcoqti	96	23	from	from	IN
cord-345762-khvcoqti	96	24	non	non	JJ
cord-345762-khvcoqti	96	25	-	-	JJ
cord-345762-khvcoqti	96	26	inferiority	inferiority	NN
cord-345762-khvcoqti	96	27	to	to	IN
cord-345762-khvcoqti	96	28	superiority	superiority	NN
cord-345762-khvcoqti	96	29	,	,	,
cord-345762-khvcoqti	96	30	alter	alter	VB
cord-345762-khvcoqti	96	31	number	number	NN
cord-345762-khvcoqti	96	32	and	and	CC
cord-345762-khvcoqti	96	33	spacing	spacing	NN
cord-345762-khvcoqti	96	34	of	of	IN
cord-345762-khvcoqti	96	35	interim	interim	JJ
cord-345762-khvcoqti	96	36	analyses	analysis	NNS
cord-345762-khvcoqti	96	37	,	,	,
cord-345762-khvcoqti	96	38	investigate	investigate	VB
cord-345762-khvcoqti	96	39	a	a	DT
cord-345762-khvcoqti	96	40	larger	large	JJR
cord-345762-khvcoqti	96	41	dose	dose	NN
cord-345762-khvcoqti	96	42	range	range	NN
cord-345762-khvcoqti	96	43	in	in	IN
cord-345762-khvcoqti	96	44	order	order	NN
cord-345762-khvcoqti	96	45	to	to	TO
cord-345762-khvcoqti	96	46	select	select	VB
cord-345762-khvcoqti	96	47	effective	effective	JJ
cord-345762-khvcoqti	96	48	doses	dose	NNS
cord-345762-khvcoqti	96	49	,	,	,
cord-345762-khvcoqti	96	50	incorporate	incorporate	VB
cord-345762-khvcoqti	96	51	biomarkers	biomarker	NNS
cord-345762-khvcoqti	96	52	that	that	WDT
cord-345762-khvcoqti	96	53	may	may	MD
cord-345762-khvcoqti	96	54	predict	predict	VB
cord-345762-khvcoqti	96	55	differential	differential	JJ
cord-345762-khvcoqti	96	56	treatment	treatment	NN
cord-345762-khvcoqti	96	57	response	response	NN
cord-345762-khvcoqti	96	58	and	and	CC
cord-345762-khvcoqti	96	59	proceed	proceed	VB
cord-345762-khvcoqti	96	60	to	to	IN
cord-345762-khvcoqti	96	61	completion	completion	NN
cord-345762-khvcoqti	96	62	with	with	IN
cord-345762-khvcoqti	96	63	increased	increase	VBN
cord-345762-khvcoqti	96	64	enrolment	enrolment	NN
cord-345762-khvcoqti	96	65	and	and	CC
cord-345762-khvcoqti	96	66	resolution	resolution	NN
cord-345762-khvcoqti	96	67	of	of	IN
cord-345762-khvcoqti	96	68	responses	response	NNS
cord-345762-khvcoqti	96	69	in	in	IN
cord-345762-khvcoqti	96	70	all	all	DT
cord-345762-khvcoqti	96	71	enrolled	enrol	VBN
cord-345762-khvcoqti	96	72	patients	patient	NNS
cord-345762-khvcoqti	96	73	,	,	,
cord-345762-khvcoqti	96	74	instead	instead	RB
cord-345762-khvcoqti	96	75	of	of	IN
cord-345762-khvcoqti	96	76	being	be	VBG
cord-345762-khvcoqti	96	77	terminated	terminate	VBN
cord-345762-khvcoqti	96	78	early	early	RB
cord-345762-khvcoqti	96	79	with	with	IN
cord-345762-khvcoqti	96	80	risk	risk	NN
cord-345762-khvcoqti	96	81	of	of	IN
cord-345762-khvcoqti	96	82	compromise	compromise	NN
cord-345762-khvcoqti	96	83	from	from	IN
cord-345762-khvcoqti	96	84	unknown	unknown	JJ
cord-345762-khvcoqti	96	85	or	or	CC
cord-345762-khvcoqti	96	86	unadjudicated	unadjudicated	JJ
cord-345762-khvcoqti	96	87	responses	response	NNS
cord-345762-khvcoqti	96	88	.	.	.
cord-345762-khvcoqti	97	1	Platform	platform	NN
cord-345762-khvcoqti	97	2	protocols	protocol	NNS
cord-345762-khvcoqti	97	3	Platform	Platform	NNP
cord-345762-khvcoqti	97	4	protocols	protocol	NNS
cord-345762-khvcoqti	97	5	facilitate	facilitate	VBP
cord-345762-khvcoqti	97	6	the	the	DT
cord-345762-khvcoqti	97	7	study	study	NN
cord-345762-khvcoqti	97	8	of	of	IN
cord-345762-khvcoqti	97	9	multiple	multiple	JJ
cord-345762-khvcoqti	97	10	targeted	target	VBN
cord-345762-khvcoqti	97	11	therapies	therapy	NNS
cord-345762-khvcoqti	97	12	in	in	IN
cord-345762-khvcoqti	97	13	a	a	DT
cord-345762-khvcoqti	97	14	perpetual	perpetual	JJ
cord-345762-khvcoqti	97	15	manner	manner	NN
cord-345762-khvcoqti	97	16	,	,	,
cord-345762-khvcoqti	97	17	with	with	IN
cord-345762-khvcoqti	97	18	therapies	therapy	NNS
cord-345762-khvcoqti	97	19	allowed	allow	VBN
cord-345762-khvcoqti	97	20	to	to	TO
cord-345762-khvcoqti	97	21	enter	enter	VB
cord-345762-khvcoqti	97	22	or	or	CC
cord-345762-khvcoqti	97	23	leave	leave	VB
cord-345762-khvcoqti	97	24	the	the	DT
cord-345762-khvcoqti	97	25	platform	platform	NN
cord-345762-khvcoqti	97	26	on	on	IN
cord-345762-khvcoqti	97	27	the	the	DT
cord-345762-khvcoqti	97	28	basis	basis	NN
cord-345762-khvcoqti	97	29	of	of	IN
cord-345762-khvcoqti	97	30	a	a	DT
cord-345762-khvcoqti	97	31	decision	decision	NN
cord-345762-khvcoqti	97	32	algorithm	algorithm	NN
cord-345762-khvcoqti	97	33	or	or	CC
cord-345762-khvcoqti	97	34	stopping	stop	VBG
cord-345762-khvcoqti	97	35	rule	rule	NN
cord-345762-khvcoqti	97	36	.	.	.
cord-345762-khvcoqti	98	1	The	the	DT
cord-345762-khvcoqti	98	2	platform	platform	NN
cord-345762-khvcoqti	98	3	trial	trial	NN
cord-345762-khvcoqti	98	4	is	be	VBZ
cord-345762-khvcoqti	98	5	ongoing	ongoing	JJ
cord-345762-khvcoqti	98	6	over	over	IN
cord-345762-khvcoqti	98	7	time	time	NN
cord-345762-khvcoqti	98	8	,	,	,
cord-345762-khvcoqti	98	9	with	with	IN
cord-345762-khvcoqti	98	10	no	no	DT
cord-345762-khvcoqti	98	11	fixed	fix	VBN
cord-345762-khvcoqti	98	12	finish	finish	NN
cord-345762-khvcoqti	98	13	date	date	NN
cord-345762-khvcoqti	98	14	,	,	,
cord-345762-khvcoqti	98	15	and	and	CC
cord-345762-khvcoqti	98	16	is	be	VBZ
cord-345762-khvcoqti	98	17	governed	govern	VBN
cord-345762-khvcoqti	98	18	by	by	IN
cord-345762-khvcoqti	98	19	a	a	DT
cord-345762-khvcoqti	98	20	master	master	NN
cord-345762-khvcoqti	98	21	protocol	protocol	NN
cord-345762-khvcoqti	98	22	that	that	WDT
cord-345762-khvcoqti	98	23	envisions	envision	VBZ
cord-345762-khvcoqti	98	24	adding	add	VBG
cord-345762-khvcoqti	98	25	and	and	CC
cord-345762-khvcoqti	98	26	dropping	drop	VBG
cord-345762-khvcoqti	98	27	strata	strata	NN
cord-345762-khvcoqti	98	28	.	.	.
cord-345762-khvcoqti	99	1	At	at	IN
cord-345762-khvcoqti	99	2	trial	trial	NN
cord-345762-khvcoqti	99	3	start	start	NN
cord-345762-khvcoqti	99	4	,	,	,
cord-345762-khvcoqti	99	5	entering	enter	VBG
cord-345762-khvcoqti	99	6	patients	patient	NNS
cord-345762-khvcoqti	99	7	are	be	VBP
cord-345762-khvcoqti	99	8	assigned	assign	VBN
cord-345762-khvcoqti	99	9	to	to	IN
cord-345762-khvcoqti	99	10	different	different	JJ
cord-345762-khvcoqti	99	11	strata	stratum	NNS
cord-345762-khvcoqti	99	12	(	(	-LRB-
cord-345762-khvcoqti	99	13	potentially	potentially	RB
cord-345762-khvcoqti	99	14	on	on	IN
cord-345762-khvcoqti	99	15	the	the	DT
cord-345762-khvcoqti	99	16	basis	basis	NN
cord-345762-khvcoqti	99	17	of	of	IN
cord-345762-khvcoqti	99	18	illness	illness	NN
cord-345762-khvcoqti	99	19	severity	severity	NN
cord-345762-khvcoqti	99	20	,	,	,
cord-345762-khvcoqti	99	21	such	such	JJ
cord-345762-khvcoqti	99	22	as	as	IN
cord-345762-khvcoqti	99	23	severe	severe	JJ
cord-345762-khvcoqti	99	24	(	(	-LRB-
cord-345762-khvcoqti	99	25	A	a	NN
cord-345762-khvcoqti	99	26	)	)	-RRB-
cord-345762-khvcoqti	99	27	,	,	,
cord-345762-khvcoqti	99	28	moderate	moderate	JJ
cord-345762-khvcoqti	99	29	(	(	-LRB-
cord-345762-khvcoqti	99	30	B	b	NN
cord-345762-khvcoqti	99	31	)	)	-RRB-
cord-345762-khvcoqti	99	32	or	or	CC
cord-345762-khvcoqti	99	33	mild	mild	JJ
cord-345762-khvcoqti	99	34	(	(	-LRB-
cord-345762-khvcoqti	99	35	C	C	NNP
cord-345762-khvcoqti	99	36	)	)	-RRB-
cord-345762-khvcoqti	99	37	COVID-19	COVID-19	NNP
cord-345762-khvcoqti	99	38	disease	disease	NN
cord-345762-khvcoqti	99	39	)	)	-RRB-
cord-345762-khvcoqti	99	40	.	.	.
cord-345762-khvcoqti	100	1	Strata	Strata	NNP
cord-345762-khvcoqti	100	2	A	a	DT
cord-345762-khvcoqti	100	3	patients	patient	NNS
cord-345762-khvcoqti	100	4	are	be	VBP
cord-345762-khvcoqti	100	5	then	then	RB
cord-345762-khvcoqti	100	6	randomly	randomly	RB
cord-345762-khvcoqti	100	7	assigned	assign	VBN
cord-345762-khvcoqti	100	8	to	to	IN
cord-345762-khvcoqti	100	9	one	one	CD
cord-345762-khvcoqti	100	10	of	of	IN
cord-345762-khvcoqti	100	11	three	three	CD
cord-345762-khvcoqti	100	12	groups	group	NNS
cord-345762-khvcoqti	100	13	,	,	,
cord-345762-khvcoqti	100	14	testing	test	VBG
cord-345762-khvcoqti	100	15	two	two	CD
cord-345762-khvcoqti	100	16	investigational	investigational	JJ
cord-345762-khvcoqti	100	17	drugs	drug	NNS
cord-345762-khvcoqti	100	18	(	(	-LRB-
cord-345762-khvcoqti	100	19	drugs	drug	NNS
cord-345762-khvcoqti	100	20	1	1	CD
cord-345762-khvcoqti	100	21	and	and	CC
cord-345762-khvcoqti	100	22	2	2	CD
cord-345762-khvcoqti	100	23	)	)	-RRB-
cord-345762-khvcoqti	100	24	against	against	IN
cord-345762-khvcoqti	100	25	placebo	placebo	NN
cord-345762-khvcoqti	100	26	.	.	.
cord-345762-khvcoqti	101	1	When	when	WRB
cord-345762-khvcoqti	101	2	investigational	investigational	JJ
cord-345762-khvcoqti	101	3	drug	drug	NN
cord-345762-khvcoqti	101	4	1	1	CD
cord-345762-khvcoqti	101	5	meets	meet	VBZ
cord-345762-khvcoqti	101	6	the	the	DT
cord-345762-khvcoqti	101	7	pre	pre	JJ
cord-345762-khvcoqti	101	8	-	-	JJ
cord-345762-khvcoqti	101	9	specified	specified	JJ
cord-345762-khvcoqti	101	10	criteria	criterion	NNS
cord-345762-khvcoqti	101	11	for	for	IN
cord-345762-khvcoqti	101	12	success	success	NN
cord-345762-khvcoqti	101	13	(	(	-LRB-
cord-345762-khvcoqti	101	14	based	base	VBN
cord-345762-khvcoqti	101	15	on	on	IN
cord-345762-khvcoqti	101	16	,	,	,
cord-345762-khvcoqti	101	17	in	in	IN
cord-345762-khvcoqti	101	18	many	many	JJ
cord-345762-khvcoqti	101	19	instances	instance	NNS
cord-345762-khvcoqti	101	20	,	,	,
cord-345762-khvcoqti	101	21	the	the	DT
cord-345762-khvcoqti	101	22	Bayesian	Bayesian	NNP
cord-345762-khvcoqti	101	23	likelihood	likelihood	NN
cord-345762-khvcoqti	101	24	of	of	IN
cord-345762-khvcoqti	101	25	a	a	DT
cord-345762-khvcoqti	101	26	treatment	treatment	NN
cord-345762-khvcoqti	101	27	benefit	benefit	NN
cord-345762-khvcoqti	101	28	)	)	-RRB-
cord-345762-khvcoqti	101	29	,	,	,
cord-345762-khvcoqti	101	30	drug	drug	NN
cord-345762-khvcoqti	101	31	1	1	CD
cord-345762-khvcoqti	101	32	replaces	replace	VBZ
cord-345762-khvcoqti	101	33	the	the	DT
cord-345762-khvcoqti	101	34	placebo	placebo	NN
cord-345762-khvcoqti	101	35	group	group	NN
cord-345762-khvcoqti	101	36	as	as	IN
cord-345762-khvcoqti	101	37	the	the	DT
cord-345762-khvcoqti	101	38	control	control	NN
cord-345762-khvcoqti	101	39	.	.	.
cord-345762-khvcoqti	102	1	From	from	IN
cord-345762-khvcoqti	102	2	this	this	DT
cord-345762-khvcoqti	102	3	point	point	NN
cord-345762-khvcoqti	102	4	,	,	,
cord-345762-khvcoqti	102	5	newly	newly	RB
cord-345762-khvcoqti	102	6	recruited	recruit	VBN
cord-345762-khvcoqti	102	7	patients	patient	NNS
cord-345762-khvcoqti	102	8	are	be	VBP
cord-345762-khvcoqti	102	9	randomised	randomised	JJ
cord-345762-khvcoqti	102	10	to	to	IN
cord-345762-khvcoqti	102	11	another	another	DT
cord-345762-khvcoqti	102	12	investigational	investigational	JJ
cord-345762-khvcoqti	102	13	drug	drug	NN
cord-345762-khvcoqti	102	14	(	(	-LRB-
cord-345762-khvcoqti	102	15	drug	drug	NN
cord-345762-khvcoqti	102	16	X	X	NNP
cord-345762-khvcoqti	102	17	)	)	-RRB-
cord-345762-khvcoqti	102	18	,	,	,
cord-345762-khvcoqti	102	19	and	and	CC
cord-345762-khvcoqti	102	20	the	the	DT
cord-345762-khvcoqti	102	21	new	new	JJ
cord-345762-khvcoqti	102	22	control	control	NN
cord-345762-khvcoqti	102	23	group	group	NN
cord-345762-khvcoqti	102	24	becomes	become	VBZ
cord-345762-khvcoqti	102	25	drug	drug	NN
cord-345762-khvcoqti	102	26	1	1	CD
cord-345762-khvcoqti	102	27	,	,	,
cord-345762-khvcoqti	102	28	while	while	IN
cord-345762-khvcoqti	102	29	recruitment	recruitment	NN
cord-345762-khvcoqti	102	30	of	of	IN
cord-345762-khvcoqti	102	31	patients	patient	NNS
cord-345762-khvcoqti	102	32	into	into	IN
cord-345762-khvcoqti	102	33	the	the	DT
cord-345762-khvcoqti	102	34	previous	previous	JJ
cord-345762-khvcoqti	102	35	protocol	protocol	NN
cord-345762-khvcoqti	102	36	comparing	compare	VBG
cord-345762-khvcoqti	102	37	drugs	drug	NNS
cord-345762-khvcoqti	102	38	1	1	CD
cord-345762-khvcoqti	102	39	and	and	CC
cord-345762-khvcoqti	102	40	2	2	CD
cord-345762-khvcoqti	102	41	completes	complete	VBZ
cord-345762-khvcoqti	102	42	enrolment	enrolment	NN
cord-345762-khvcoqti	102	43	and	and	CC
cord-345762-khvcoqti	102	44	is	be	VBZ
cord-345762-khvcoqti	102	45	ceased	cease	VBN
cord-345762-khvcoqti	102	46	.	.	.
cord-345762-khvcoqti	103	1	In	in	IN
cord-345762-khvcoqti	103	2	a	a	DT
cord-345762-khvcoqti	103	3	similar	similar	JJ
cord-345762-khvcoqti	103	4	manner	manner	NN
cord-345762-khvcoqti	103	5	,	,	,
cord-345762-khvcoqti	103	6	strata	strata	NN
cord-345762-khvcoqti	103	7	B	b	NN
cord-345762-khvcoqti	103	8	patients	patient	NNS
cord-345762-khvcoqti	103	9	may	may	MD
cord-345762-khvcoqti	103	10	also	also	RB
cord-345762-khvcoqti	103	11	be	be	VB
cord-345762-khvcoqti	103	12	randomised	randomised	JJ
cord-345762-khvcoqti	103	13	to	to	IN
cord-345762-khvcoqti	103	14	drugs	drug	NNS
cord-345762-khvcoqti	103	15	1	1	CD
cord-345762-khvcoqti	103	16	and	and	CC
cord-345762-khvcoqti	103	17	2	2	CD
cord-345762-khvcoqti	103	18	or	or	CC
cord-345762-khvcoqti	103	19	placebo	placebo	NN
cord-345762-khvcoqti	103	20	or	or	CC
cord-345762-khvcoqti	103	21	to	to	IN
cord-345762-khvcoqti	103	22	different	different	JJ
cord-345762-khvcoqti	103	23	drugs	drug	NNS
cord-345762-khvcoqti	103	24	(	(	-LRB-
cord-345762-khvcoqti	103	25	drugs	drug	NNS
cord-345762-khvcoqti	103	26	3	3	CD
cord-345762-khvcoqti	103	27	and	and	CC
cord-345762-khvcoqti	103	28	4	4	CD
cord-345762-khvcoqti	103	29	)	)	-RRB-
cord-345762-khvcoqti	103	30	or	or	CC
cord-345762-khvcoqti	103	31	placebo	placebo	NN
cord-345762-khvcoqti	103	32	.	.	.
cord-345762-khvcoqti	104	1	In	in	IN
cord-345762-khvcoqti	104	2	a	a	DT
cord-345762-khvcoqti	104	3	similar	similar	JJ
cord-345762-khvcoqti	104	4	manner	manner	NN
cord-345762-khvcoqti	104	5	to	to	TO
cord-345762-khvcoqti	104	6	strata	strata	VB
cord-345762-khvcoqti	104	7	A	A	NNP
cord-345762-khvcoqti	104	8	,	,	,
cord-345762-khvcoqti	104	9	whichever	whichever	WDT
cord-345762-khvcoqti	104	10	drug	drug	NN
cord-345762-khvcoqti	104	11	shows	show	VBZ
cord-345762-khvcoqti	104	12	superiority	superiority	NN
cord-345762-khvcoqti	104	13	in	in	IN
cord-345762-khvcoqti	104	14	strata	strata	NN
cord-345762-khvcoqti	104	15	B	b	NN
cord-345762-khvcoqti	104	16	then	then	RB
cord-345762-khvcoqti	104	17	becomes	become	VBZ
cord-345762-khvcoqti	104	18	the	the	DT
cord-345762-khvcoqti	104	19	control	control	NN
cord-345762-khvcoqti	104	20	group	group	NN
cord-345762-khvcoqti	104	21	for	for	IN
cord-345762-khvcoqti	104	22	newly	newly	RB
cord-345762-khvcoqti	104	23	recruited	recruit	VBN
cord-345762-khvcoqti	104	24	patients	patient	NNS
cord-345762-khvcoqti	104	25	into	into	IN
cord-345762-khvcoqti	104	26	that	that	DT
cord-345762-khvcoqti	104	27	strata	strata	NN
cord-345762-khvcoqti	104	28	once	once	IN
cord-345762-khvcoqti	104	29	patient	patient	JJ
cord-345762-khvcoqti	104	30	enrolment	enrolment	NN
cord-345762-khvcoqti	104	31	is	be	VBZ
cord-345762-khvcoqti	104	32	completed	complete	VBN
cord-345762-khvcoqti	104	33	for	for	IN
cord-345762-khvcoqti	104	34	the	the	DT
cord-345762-khvcoqti	104	35	first	first	JJ
cord-345762-khvcoqti	104	36	protocol	protocol	NN
cord-345762-khvcoqti	104	37	.	.	.
cord-345762-khvcoqti	105	1	The	the	DT
cord-345762-khvcoqti	105	2	same	same	JJ
cord-345762-khvcoqti	105	3	process	process	NN
cord-345762-khvcoqti	105	4	applies	apply	VBZ
cord-345762-khvcoqti	105	5	to	to	IN
cord-345762-khvcoqti	105	6	strata	strata	NNP
cord-345762-khvcoqti	105	7	C.	C.	NNP
cord-345762-khvcoqti	106	1	The	the	DT
cord-345762-khvcoqti	106	2	design	design	NN
cord-345762-khvcoqti	106	3	can	can	MD
cord-345762-khvcoqti	106	4	also	also	RB
cord-345762-khvcoqti	106	5	accommodate	accommodate	VB
cord-345762-khvcoqti	106	6	comparisons	comparison	NNS
cord-345762-khvcoqti	106	7	of	of	IN
cord-345762-khvcoqti	106	8	drug	drug	NN
cord-345762-khvcoqti	106	9	combinations	combination	NNS
cord-345762-khvcoqti	106	10	(	(	-LRB-
cord-345762-khvcoqti	106	11	e.g.	e.g.	IN
cord-345762-khvcoqti	106	12	drugs	drug	NNS
cord-345762-khvcoqti	106	13	1	1	CD
cord-345762-khvcoqti	106	14	+	+	SYM
cord-345762-khvcoqti	106	15	2	2	CD
cord-345762-khvcoqti	106	16	vs	vs	IN
cord-345762-khvcoqti	106	17	placebo	placebo	NN
cord-345762-khvcoqti	106	18	or	or	CC
cord-345762-khvcoqti	106	19	drugs	drug	NNS
cord-345762-khvcoqti	106	20	1	1	CD
cord-345762-khvcoqti	106	21	and	and	CC
cord-345762-khvcoqti	106	22	X	X	NNP
cord-345762-khvcoqti	106	23	vs	vs	IN
cord-345762-khvcoqti	106	24	drug	drug	NN
cord-345762-khvcoqti	106	25	1	1	CD
cord-345762-khvcoqti	106	26	)	)	-RRB-
cord-345762-khvcoqti	106	27	.	.	.
cord-345762-khvcoqti	107	1	The	the	DT
cord-345762-khvcoqti	107	2	statistical	statistical	JJ
cord-345762-khvcoqti	107	3	methods	method	NNS
cord-345762-khvcoqti	107	4	throughout	throughout	IN
cord-345762-khvcoqti	107	5	involve	involve	VBP
cord-345762-khvcoqti	107	6	randomised	randomised	JJ
cord-345762-khvcoqti	107	7	treatment	treatment	NN
cord-345762-khvcoqti	107	8	assignment	assignment	NN
cord-345762-khvcoqti	107	9	,	,	,
cord-345762-khvcoqti	107	10	sharing	sharing	NN
cord-345762-khvcoqti	107	11	of	of	IN
cord-345762-khvcoqti	107	12	common	common	JJ
cord-345762-khvcoqti	107	13	control	control	NN
cord-345762-khvcoqti	107	14	patients	patient	NNS
cord-345762-khvcoqti	107	15	and	and	CC
cord-345762-khvcoqti	107	16	sequential	sequential	JJ
cord-345762-khvcoqti	107	17	interim	interim	JJ
cord-345762-khvcoqti	107	18	analyses	analysis	NNS
cord-345762-khvcoqti	107	19	with	with	IN
cord-345762-khvcoqti	107	20	the	the	DT
cord-345762-khvcoqti	107	21	possibility	possibility	NN
cord-345762-khvcoqti	107	22	of	of	IN
cord-345762-khvcoqti	107	23	stopping	stop	VBG
cord-345762-khvcoqti	107	24	early	early	RB
cord-345762-khvcoqti	107	25	for	for	IN
cord-345762-khvcoqti	107	26	futility	futility	NN
cord-345762-khvcoqti	107	27	.	.	.
cord-345762-khvcoqti	108	1	Internal	Internal	NNP
cord-345762-khvcoqti	108	2	Medicine	Medicine	NNP
cord-345762-khvcoqti	108	3	Journal	Journal	NNP
cord-345762-khvcoqti	108	4	50	50	CD
cord-345762-khvcoqti	108	5	(	(	-LRB-
cord-345762-khvcoqti	108	6	2020	2020	CD
cord-345762-khvcoqti	108	7	)	)	-RRB-
cord-345762-khvcoqti	109	1	904	904	CD
cord-345762-khvcoqti	109	2	-	-	SYM
cord-345762-khvcoqti	109	3	909	909	CD
cord-345762-khvcoqti	109	4	seeking	seek	VBG
cord-345762-khvcoqti	109	5	definitive	definitive	JJ
cord-345762-khvcoqti	109	6	evidence	evidence	NN
cord-345762-khvcoqti	109	7	of	of	IN
cord-345762-khvcoqti	109	8	the	the	DT
cord-345762-khvcoqti	109	9	benefits	benefit	NNS
cord-345762-khvcoqti	109	10	and	and	CC
cord-345762-khvcoqti	109	11	harms	harm	NNS
cord-345762-khvcoqti	109	12	of	of	IN
cord-345762-khvcoqti	109	13	any	any	DT
cord-345762-khvcoqti	109	14	proposed	propose	VBN
cord-345762-khvcoqti	109	15	treatment	treatment	NN
cord-345762-khvcoqti	109	16	by	by	IN
cord-345762-khvcoqti	109	17	enrolling	enrol	VBG
cord-345762-khvcoqti	109	18	patients	patient	NNS
cord-345762-khvcoqti	109	19	into	into	IN
cord-345762-khvcoqti	109	20	multisite	multisite	JJ
cord-345762-khvcoqti	109	21	RCT	RCT	NNP
cord-345762-khvcoqti	109	22	that	that	WDT
cord-345762-khvcoqti	109	23	are	be	VBP
cord-345762-khvcoqti	109	24	being	be	VBG
cord-345762-khvcoqti	109	25	transparently	transparently	RB
cord-345762-khvcoqti	109	26	conducted	conduct	VBN
cord-345762-khvcoqti	109	27	in	in	IN
cord-345762-khvcoqti	109	28	communication	communication	NN
cord-345762-khvcoqti	109	29	with	with	IN
cord-345762-khvcoqti	109	30	global	global	JJ
cord-345762-khvcoqti	109	31	partners	partner	NNS
cord-345762-khvcoqti	109	32	.	.	.
cord-345762-khvcoqti	110	1	This	this	DT
cord-345762-khvcoqti	110	2	strategy	strategy	NN
cord-345762-khvcoqti	110	3	allows	allow	VBZ
cord-345762-khvcoqti	110	4	clinicians	clinician	NNS
cord-345762-khvcoqti	110	5	to	to	TO
cord-345762-khvcoqti	110	6	be	be	VB
cord-345762-khvcoqti	110	7	satisfied	satisfied	JJ
cord-345762-khvcoqti	110	8	that	that	IN
cord-345762-khvcoqti	110	9	they	-PRON-	PRP
cord-345762-khvcoqti	110	10	are	be	VBP
cord-345762-khvcoqti	110	11	doing	do	VBG
cord-345762-khvcoqti	110	12	everything	everything	NN
cord-345762-khvcoqti	110	13	possible	possible	JJ
cord-345762-khvcoqti	110	14	for	for	IN
cord-345762-khvcoqti	110	15	their	-PRON-	PRP$
cord-345762-khvcoqti	110	16	severely	severely	RB
cord-345762-khvcoqti	110	17	ill	ill	JJ
cord-345762-khvcoqti	110	18	patients	patient	NNS
cord-345762-khvcoqti	110	19	while	while	IN
cord-345762-khvcoqti	110	20	contributing	contribute	VBG
cord-345762-khvcoqti	110	21	to	to	IN
cord-345762-khvcoqti	110	22	new	new	JJ
cord-345762-khvcoqti	110	23	knowledgean	knowledgean	NN
cord-345762-khvcoqti	110	24	approach	approach	NN
cord-345762-khvcoqti	110	25	with	with	IN
cord-345762-khvcoqti	110	26	which	which	WDT
cord-345762-khvcoqti	110	27	patients	patient	NNS
cord-345762-khvcoqti	110	28	also	also	RB
cord-345762-khvcoqti	110	29	agree	agree	VBP
cord-345762-khvcoqti	110	30	.	.	.
cord-345762-khvcoqti	111	1	35	35	CD
cord-345762-khvcoqti	111	2	We	-PRON-	PRP
cord-345762-khvcoqti	111	3	must	must	MD
cord-345762-khvcoqti	111	4	avoid	avoid	VB
cord-345762-khvcoqti	111	5	the	the	DT
cord-345762-khvcoqti	111	6	'	'	``
cord-345762-khvcoqti	111	7	just	just	RB
cord-345762-khvcoqti	111	8	do	do	VB
cord-345762-khvcoqti	111	9	it	-PRON-	PRP
cord-345762-khvcoqti	111	10	'	'	''
cord-345762-khvcoqti	111	11	option	option	NN
cord-345762-khvcoqti	111	12	of	of	IN
cord-345762-khvcoqti	111	13	administering	administer	VBG
cord-345762-khvcoqti	111	14	therapies	therapy	NNS
cord-345762-khvcoqti	111	15	based	base	VBN
cord-345762-khvcoqti	111	16	on	on	IN
cord-345762-khvcoqti	111	17	unreliable	unreliable	JJ
cord-345762-khvcoqti	111	18	observational	observational	JJ
cord-345762-khvcoqti	111	19	evidence	evidence	NN
cord-345762-khvcoqti	111	20	and	and	CC
cord-345762-khvcoqti	111	21	instead	instead	RB
cord-345762-khvcoqti	111	22	commit	commit	VB
cord-345762-khvcoqti	111	23	to	to	IN
cord-345762-khvcoqti	111	24	reducing	reduce	VBG
cord-345762-khvcoqti	111	25	uncertainty	uncertainty	NN
cord-345762-khvcoqti	111	26	by	by	IN
cord-345762-khvcoqti	111	27	testing	test	VBG
cord-345762-khvcoqti	111	28	therapies	therapy	NNS
cord-345762-khvcoqti	111	29	in	in	IN
cord-345762-khvcoqti	111	30	RCT	RCT	NNP
cord-345762-khvcoqti	111	31	as	as	IN
cord-345762-khvcoqti	111	32	the	the	DT
cord-345762-khvcoqti	111	33	'	'	``
cord-345762-khvcoqti	111	34	must	must	MD
cord-345762-khvcoqti	111	35	learn	learn	VB
cord-345762-khvcoqti	111	36	'	'	``
cord-345762-khvcoqti	111	37	alternative	alternative	NN
cord-345762-khvcoqti	111	38	.	.	.
cord-345762-khvcoqti	112	1	It	-PRON-	PRP
cord-345762-khvcoqti	112	2	is	be	VBZ
cord-345762-khvcoqti	112	3	not	not	RB
cord-345762-khvcoqti	112	4	a	a	DT
cord-345762-khvcoqti	112	5	matter	matter	NN
cord-345762-khvcoqti	112	6	of	of	IN
cord-345762-khvcoqti	112	7	choosing	choose	VBG
cord-345762-khvcoqti	112	8	between	between	IN
cord-345762-khvcoqti	112	9	one	one	CD
cord-345762-khvcoqti	112	10	or	or	CC
cord-345762-khvcoqti	112	11	the	the	DT
cord-345762-khvcoqti	112	12	other	other	JJ
cord-345762-khvcoqti	112	13	.	.	.
cord-345762-khvcoqti	113	1	for	for	IN
cord-345762-khvcoqti	113	2	unproven	unproven	JJ
cord-345762-khvcoqti	113	3	COVID-19	COVID-19	NNP
cord-345762-khvcoqti	113	4	therapies	therapy	NNS
cord-345762-khvcoqti	113	5	in	in	IN
cord-345762-khvcoqti	113	6	the	the	DT
cord-345762-khvcoqti	113	7	United	United	NNP
cord-345762-khvcoqti	113	8	States	States	NNP
cord-345762-khvcoqti	113	9	Severe	Severe	NNP
cord-345762-khvcoqti	113	10	acute	acute	JJ
cord-345762-khvcoqti	113	11	respiratory	respiratory	JJ
cord-345762-khvcoqti	113	12	syndrome	syndrome	NN
cord-345762-khvcoqti	113	13	coronavirus	coronavirus	NN
cord-345762-khvcoqti	113	14	2	2	CD
cord-345762-khvcoqti	114	1	(	(	-LRB-
cord-345762-khvcoqti	114	2	SARS	SARS	NNP
cord-345762-khvcoqti	114	3	-	-	HYPH
cord-345762-khvcoqti	114	4	CoV-2	CoV-2	NNP
cord-345762-khvcoqti	114	5	)	)	-RRB-
cord-345762-khvcoqti	114	6	and	and	CC
cord-345762-khvcoqti	114	7	coronavirus	coronavirus	NN
cord-345762-khvcoqti	114	8	disease-2019	disease-2019	NNP
cord-345762-khvcoqti	114	9	(	(	-LRB-
cord-345762-khvcoqti	114	10	COVID-19	COVID-19	NNP
cord-345762-khvcoqti	114	11	)	)	-RRB-
cord-345762-khvcoqti	114	12	:	:	:
cord-345762-khvcoqti	115	1	the	the	DT
cord-345762-khvcoqti	115	2	epidemic	epidemic	NN
cord-345762-khvcoqti	115	3	and	and	CC
cord-345762-khvcoqti	115	4	the	the	DT
cord-345762-khvcoqti	115	5	challenges	challenge	NNS
cord-345762-khvcoqti	116	1	Prominent	prominent	JJ
cord-345762-khvcoqti	116	2	changes	change	NNS
cord-345762-khvcoqti	116	3	in	in	IN
cord-345762-khvcoqti	116	4	blood	blood	NN
cord-345762-khvcoqti	116	5	coagulation	coagulation	NN
cord-345762-khvcoqti	116	6	of	of	IN
cord-345762-khvcoqti	116	7	patients	patient	NNS
cord-345762-khvcoqti	116	8	with	with	IN
cord-345762-khvcoqti	116	9	SARS	SARS	NNP
cord-345762-khvcoqti	116	10	-	-	HYPH
cord-345762-khvcoqti	116	11	CoV-2	CoV-2	NNP
cord-345762-khvcoqti	116	12	infection	infection	NN
cord-345762-khvcoqti	116	13	Incidence	incidence	NN
cord-345762-khvcoqti	116	14	of	of	IN
cord-345762-khvcoqti	116	15	thrombotic	thrombotic	JJ
cord-345762-khvcoqti	116	16	complications	complication	NNS
cord-345762-khvcoqti	116	17	in	in	IN
cord-345762-khvcoqti	116	18	critically	critically	RB
cord-345762-khvcoqti	116	19	ill	ill	JJ
cord-345762-khvcoqti	116	20	ICU	ICU	NNP
cord-345762-khvcoqti	116	21	patients	patient	NNS
cord-345762-khvcoqti	116	22	with	with	IN
cord-345762-khvcoqti	116	23	COVID-19	COVID-19	NNP
cord-345762-khvcoqti	116	24	Association	Association	NNP
cord-345762-khvcoqti	116	25	of	of	IN
cord-345762-khvcoqti	116	26	treatment	treatment	NN
cord-345762-khvcoqti	116	27	dose	dose	NN
cord-345762-khvcoqti	116	28	anticoagulation	anticoagulation	NN
cord-345762-khvcoqti	116	29	with	with	IN
cord-345762-khvcoqti	116	30	in	in	IN
cord-345762-khvcoqti	116	31	-	-	HYPH
cord-345762-khvcoqti	116	32	hospital	hospital	NN
cord-345762-khvcoqti	116	33	survival	survival	NN
cord-345762-khvcoqti	116	34	among	among	IN
cord-345762-khvcoqti	116	35	hospitalized	hospitalize	VBN
cord-345762-khvcoqti	116	36	patients	patient	NNS
cord-345762-khvcoqti	116	37	with	with	IN
cord-345762-khvcoqti	116	38	COVID-19	COVID-19	NNP
cord-345762-khvcoqti	116	39	Immortal	Immortal	NNP
cord-345762-khvcoqti	116	40	time	time	NN
cord-345762-khvcoqti	116	41	bias	bias	NN
cord-345762-khvcoqti	116	42	in	in	IN
cord-345762-khvcoqti	116	43	observational	observational	JJ
cord-345762-khvcoqti	116	44	studies	study	NNS
cord-345762-khvcoqti	116	45	of	of	IN
cord-345762-khvcoqti	116	46	drug	drug	NN
cord-345762-khvcoqti	116	47	effects	effect	NNS
cord-345762-khvcoqti	116	48	Using	use	VBG
cord-345762-khvcoqti	116	49	propensity	propensity	NN
cord-345762-khvcoqti	116	50	score	score	NN
cord-345762-khvcoqti	116	51	methods	method	NNS
cord-345762-khvcoqti	116	52	to	to	TO
cord-345762-khvcoqti	116	53	create	create	VB
cord-345762-khvcoqti	116	54	target	target	NN
cord-345762-khvcoqti	116	55	populations	population	NNS
cord-345762-khvcoqti	116	56	in	in	IN
cord-345762-khvcoqti	116	57	observational	observational	JJ
cord-345762-khvcoqti	116	58	clinical	clinical	JJ
cord-345762-khvcoqti	116	59	research	research	NN
cord-345762-khvcoqti	116	60	Efficacy	Efficacy	NNP
cord-345762-khvcoqti	116	61	of	of	IN
cord-345762-khvcoqti	116	62	hydroxychloroquine	hydroxychloroquine	NN
cord-345762-khvcoqti	116	63	in	in	IN
cord-345762-khvcoqti	116	64	patients	patient	NNS
cord-345762-khvcoqti	116	65	with	with	IN
cord-345762-khvcoqti	116	66	COVID-19	covid-19	NN
cord-345762-khvcoqti	116	67	:	:	:
cord-345762-khvcoqti	116	68	results	result	NNS
cord-345762-khvcoqti	116	69	of	of	IN
cord-345762-khvcoqti	116	70	a	a	DT
cord-345762-khvcoqti	116	71	randomized	randomized	JJ
cord-345762-khvcoqti	116	72	clinical	clinical	JJ
cord-345762-khvcoqti	116	73	trial	trial	NN
cord-345762-khvcoqti	116	74	Hydroxychloroquine	Hydroxychloroquine	NNP
cord-345762-khvcoqti	116	75	in	in	IN
cord-345762-khvcoqti	116	76	patients	patient	NNS
cord-345762-khvcoqti	116	77	mainly	mainly	RB
cord-345762-khvcoqti	116	78	with	with	IN
cord-345762-khvcoqti	116	79	mild	mild	JJ
cord-345762-khvcoqti	116	80	to	to	TO
cord-345762-khvcoqti	116	81	moderate	moderate	JJ
cord-345762-khvcoqti	116	82	COVID-19	COVID-19	NNP
cord-345762-khvcoqti	116	83	:	:	:
cord-345762-khvcoqti	116	84	an	an	DT
cord-345762-khvcoqti	116	85	open	open	JJ
cord-345762-khvcoqti	116	86	-	-	HYPH
cord-345762-khvcoqti	116	87	label	label	NN
cord-345762-khvcoqti	116	88	,	,	,
cord-345762-khvcoqti	116	89	randomized	randomized	JJ
cord-345762-khvcoqti	116	90	,	,	,
cord-345762-khvcoqti	116	91	controlled	control	VBN
cord-345762-khvcoqti	116	92	trial	trial	NN
cord-345762-khvcoqti	116	93	Treating	treat	VBG
cord-345762-khvcoqti	116	94	COVID-19-off	covid-19-off	NN
cord-345762-khvcoqti	116	95	-	-	HYPH
cord-345762-khvcoqti	116	96	label	label	NN
cord-345762-khvcoqti	116	97	drug	drug	NN
cord-345762-khvcoqti	116	98	use	use	NN
cord-345762-khvcoqti	116	99	,	,	,
cord-345762-khvcoqti	116	100	compassionate	compassionate	JJ
cord-345762-khvcoqti	116	101	use	use	NN
cord-345762-khvcoqti	116	102	,	,	,
cord-345762-khvcoqti	116	103	and	and	CC
cord-345762-khvcoqti	116	104	randomized	randomized	JJ
cord-345762-khvcoqti	116	105	clinical	clinical	JJ
cord-345762-khvcoqti	116	106	trials	trial	NNS
cord-345762-khvcoqti	116	107	during	during	IN
cord-345762-khvcoqti	116	108	pandemics	pandemic	NNS
cord-345762-khvcoqti	117	1	Clinical	clinical	JJ
cord-345762-khvcoqti	117	2	evidence	evidence	NN
cord-345762-khvcoqti	117	3	does	do	VBZ
cord-345762-khvcoqti	117	4	not	not	RB
cord-345762-khvcoqti	117	5	support	support	VB
cord-345762-khvcoqti	117	6	corticosteroid	corticosteroid	NN
cord-345762-khvcoqti	117	7	treatment	treatment	NN
cord-345762-khvcoqti	117	8	for	for	IN
cord-345762-khvcoqti	117	9	2019-nCoV	2019-ncov	CD
cord-345762-khvcoqti	117	10	lung	lung	NN
cord-345762-khvcoqti	117	11	injury	injury	NN
cord-345762-khvcoqti	117	12	Outcomes	Outcomes	NNPS
cord-345762-khvcoqti	117	13	of	of	IN
cord-345762-khvcoqti	117	14	hydroxychloroquine	hydroxychloroquine	NN
cord-345762-khvcoqti	117	15	usage	usage	NN
cord-345762-khvcoqti	117	16	in	in	IN
cord-345762-khvcoqti	117	17	United	United	NNP
cord-345762-khvcoqti	117	18	States	States	NNP
cord-345762-khvcoqti	117	19	veterans	veteran	NNS
cord-345762-khvcoqti	117	20	hospitalized	hospitalize	VBN
cord-345762-khvcoqti	117	21	with	with	IN
cord-345762-khvcoqti	117	22	Covid-19	Covid-19	NNP
cord-345762-khvcoqti	117	23	Remdesivir	Remdesivir	NNP
cord-345762-khvcoqti	117	24	in	in	IN
cord-345762-khvcoqti	117	25	adults	adult	NNS
cord-345762-khvcoqti	117	26	with	with	IN
cord-345762-khvcoqti	117	27	severe	severe	JJ
cord-345762-khvcoqti	117	28	COVID-19	covid-19	NN
cord-345762-khvcoqti	117	29	:	:	:
cord-345762-khvcoqti	117	30	a	a	DT
cord-345762-khvcoqti	117	31	randomised	randomised	JJ
cord-345762-khvcoqti	117	32	,	,	,
cord-345762-khvcoqti	117	33	double	double	JJ
cord-345762-khvcoqti	117	34	-	-	HYPH
cord-345762-khvcoqti	117	35	blind	blind	JJ
cord-345762-khvcoqti	117	36	,	,	,
cord-345762-khvcoqti	117	37	placebo	placebo	NN
cord-345762-khvcoqti	117	38	-	-	HYPH
cord-345762-khvcoqti	117	39	controlled	control	VBN
cord-345762-khvcoqti	117	40	,	,	,
cord-345762-khvcoqti	117	41	multicentre	multicentre	NNP
cord-345762-khvcoqti	117	42	trial	trial	NN
cord-345762-khvcoqti	117	43	Remdesivir	Remdesivir	NNP
cord-345762-khvcoqti	117	44	for	for	IN
cord-345762-khvcoqti	117	45	the	the	DT
cord-345762-khvcoqti	117	46	treatment	treatment	NN
cord-345762-khvcoqti	117	47	of	of	IN
cord-345762-khvcoqti	118	1	COVID-19	COVID-19	NNP
cord-345762-khvcoqti	118	2	-Preliminary	-Preliminary	NNP
cord-345762-khvcoqti	118	3	report	report	NN
cord-345762-khvcoqti	118	4	Ethics	Ethics	NNP
cord-345762-khvcoqti	118	5	committee	committee	NN
cord-345762-khvcoqti	118	6	reviews	review	NNS
cord-345762-khvcoqti	118	7	of	of	IN
cord-345762-khvcoqti	118	8	applications	application	NNS
cord-345762-khvcoqti	118	9	for	for	IN
cord-345762-khvcoqti	118	10	research	research	NN
cord-345762-khvcoqti	118	11	studies	study	NNS
cord-345762-khvcoqti	118	12	at	at	IN
cord-345762-khvcoqti	118	13	1	1	CD
cord-345762-khvcoqti	118	14	hospital	hospital	NN
cord-345762-khvcoqti	118	15	in	in	IN
cord-345762-khvcoqti	118	16	China	China	NNP
cord-345762-khvcoqti	118	17	during	during	IN
cord-345762-khvcoqti	118	18	the	the	DT
cord-345762-khvcoqti	118	19	2019	2019	CD
cord-345762-khvcoqti	118	20	novel	novel	JJ
cord-345762-khvcoqti	118	21	coronavirus	coronavirus	NN
cord-345762-khvcoqti	118	22	epidemic	epidemic	NN
cord-345762-khvcoqti	118	23	Retraction	retraction	NN
cord-345762-khvcoqti	118	24	-	-	HYPH
cord-345762-khvcoqti	118	25	Hydroxychloroquine	Hydroxychloroquine	NNP
cord-345762-khvcoqti	118	26	or	or	CC
cord-345762-khvcoqti	118	27	chloroquine	chloroquine	NN
cord-345762-khvcoqti	118	28	with	with	IN
cord-345762-khvcoqti	118	29	or	or	CC
cord-345762-khvcoqti	118	30	without	without	IN
cord-345762-khvcoqti	118	31	a	a	DT
cord-345762-khvcoqti	118	32	macrolide	macrolide	NN
cord-345762-khvcoqti	118	33	for	for	IN
cord-345762-khvcoqti	118	34	treatment	treatment	NN
cord-345762-khvcoqti	118	35	of	of	IN
cord-345762-khvcoqti	118	36	COVID-19	COVID-19	NNP
cord-345762-khvcoqti	118	37	:	:	:
cord-345762-khvcoqti	118	38	a	a	DT
cord-345762-khvcoqti	118	39	multinational	multinational	JJ
cord-345762-khvcoqti	118	40	registry	registry	NN
cord-345762-khvcoqti	118	41	analysis	analysis	NN
cord-345762-khvcoqti	118	42	Retraction	retraction	NN
cord-345762-khvcoqti	118	43	:	:	:
cord-345762-khvcoqti	118	44	Cardiovascular	cardiovascular	JJ
cord-345762-khvcoqti	118	45	disease	disease	NN
cord-345762-khvcoqti	118	46	,	,	,
cord-345762-khvcoqti	118	47	drug	drug	NN
cord-345762-khvcoqti	118	48	therapy	therapy	NN
cord-345762-khvcoqti	118	49	,	,	,
cord-345762-khvcoqti	118	50	and	and	CC
cord-345762-khvcoqti	118	51	mortality	mortality	NN
cord-345762-khvcoqti	118	52	in	in	IN
cord-345762-khvcoqti	118	53	Covid-19	Covid-19	NNP
cord-345762-khvcoqti	118	54	Editorial	Editorial	NNP
cord-345762-khvcoqti	118	55	concern	concern	NN
cord-345762-khvcoqti	118	56	-possible	-possible	JJ
cord-345762-khvcoqti	118	57	reporting	reporting	NN
cord-345762-khvcoqti	118	58	of	of	IN
cord-345762-khvcoqti	118	59	the	the	DT
cord-345762-khvcoqti	118	60	same	same	JJ
cord-345762-khvcoqti	118	61	patients	patient	NNS
cord-345762-khvcoqti	118	62	with	with	IN
cord-345762-khvcoqti	118	63	COVID-19	COVID-19	NNP
cord-345762-khvcoqti	118	64	in	in	IN
cord-345762-khvcoqti	118	65	different	different	JJ
cord-345762-khvcoqti	118	66	reports	report	NNS
cord-345762-khvcoqti	118	67	Adaptive	adaptive	JJ
cord-345762-khvcoqti	118	68	designs	design	NNS
cord-345762-khvcoqti	118	69	for	for	IN
cord-345762-khvcoqti	118	70	clinical	clinical	JJ
cord-345762-khvcoqti	118	71	trials	trial	NNS
cord-345762-khvcoqti	118	72	©	©	NNP
cord-345762-khvcoqti	118	73	2020	2020	CD
cord-345762-khvcoqti	118	74	Royal	Royal	NNP
cord-345762-khvcoqti	118	75	Australasian	Australasian	NNP
cord-345762-khvcoqti	118	76	College	College	NNP
cord-345762-khvcoqti	118	77	of	of	IN
cord-345762-khvcoqti	118	78	Physicians	Physicians	NNP
cord-345762-khvcoqti	118	79	Parmigiani	Parmigiani	NNP
cord-345762-khvcoqti	118	80	G	G	NNP
cord-345762-khvcoqti	118	81	et	et	FW
cord-345762-khvcoqti	118	82	al	al	NNP
cord-345762-khvcoqti	118	83	.	.	.
cord-345762-khvcoqti	119	1	Bayesian	bayesian	JJ
cord-345762-khvcoqti	119	2	adaptive	adaptive	JJ
cord-345762-khvcoqti	119	3	randomized	randomized	JJ
cord-345762-khvcoqti	119	4	trial	trial	NN
cord-345762-khvcoqti	119	5	design	design	NN
cord-345762-khvcoqti	119	6	for	for	IN
cord-345762-khvcoqti	119	7	patients	patient	NNS
cord-345762-khvcoqti	119	8	with	with	IN
cord-345762-khvcoqti	119	9	recurrent	recurrent	JJ
cord-345762-khvcoqti	119	10	glioblastoma	glioblastoma	NN
cord-345762-khvcoqti	119	11	Efficiencies	efficiency	NNS
cord-345762-khvcoqti	119	12	of	of	IN
cord-345762-khvcoqti	119	13	platform	platform	NN
cord-345762-khvcoqti	119	14	clinical	clinical	JJ
cord-345762-khvcoqti	119	15	trials	trial	NNS
cord-345762-khvcoqti	119	16	:	:	:
cord-345762-khvcoqti	119	17	a	a	DT
cord-345762-khvcoqti	119	18	vision	vision	NN
cord-345762-khvcoqti	119	19	of	of	IN
cord-345762-khvcoqti	119	20	the	the	DT
cord-345762-khvcoqti	119	21	future	future	JJ
cord-345762-khvcoqti	119	22	AustralaSian	AustralaSian	NNP
cord-345762-khvcoqti	119	23	COVID-19	COVID-19	NNP
cord-345762-khvcoqti	119	24	trial	trial	NN
cord-345762-khvcoqti	119	25	(	(	-LRB-
cord-345762-khvcoqti	119	26	ASCOT	ASCOT	NNP
cord-345762-khvcoqti	119	27	)	)	-RRB-
cord-345762-khvcoqti	120	1	Covid-19	Covid-19	NNP
cord-345762-khvcoqti	120	2	:	:	:
cord-345762-khvcoqti	120	3	trials	trial	NNS
cord-345762-khvcoqti	120	4	of	of	IN
cord-345762-khvcoqti	120	5	four	four	CD
cord-345762-khvcoqti	120	6	potential	potential	JJ
cord-345762-khvcoqti	120	7	treatments	treatment	NNS
cord-345762-khvcoqti	120	8	to	to	TO
cord-345762-khvcoqti	120	9	generate	generate	VB
cord-345762-khvcoqti	120	10	'	'	``
cord-345762-khvcoqti	120	11	robust	robust	JJ
cord-345762-khvcoqti	120	12	data	datum	NNS
cord-345762-khvcoqti	120	13	'	'	''
cord-345762-khvcoqti	120	14	of	of	IN
cord-345762-khvcoqti	120	15	what	what	WP
cord-345762-khvcoqti	120	16	works	work	VBZ
cord-345762-khvcoqti	120	17	Australian	australian	JJ
cord-345762-khvcoqti	120	18	and	and	CC
cord-345762-khvcoqti	120	19	New	New	NNP
cord-345762-khvcoqti	120	20	Zealand	Zealand	NNP
cord-345762-khvcoqti	120	21	Intensive	Intensive	NNP
cord-345762-khvcoqti	120	22	Care	Care	NNP
cord-345762-khvcoqti	120	23	Society	Society	NNP
cord-345762-khvcoqti	120	24	.	.	.
cord-345762-khvcoqti	121	1	A	a	DT
cord-345762-khvcoqti	121	2	randomised	randomised	JJ
cord-345762-khvcoqti	121	3	,	,	,
cord-345762-khvcoqti	121	4	embedded	embed	VBN
cord-345762-khvcoqti	121	5	,	,	,
cord-345762-khvcoqti	121	6	multi	multi	JJ
cord-345762-khvcoqti	121	7	-	-	JJ
cord-345762-khvcoqti	121	8	factorial	factorial	JJ
cord-345762-khvcoqti	121	9	,	,	,
cord-345762-khvcoqti	121	10	adaptive	adaptive	JJ
cord-345762-khvcoqti	121	11	platform	platform	NN
cord-345762-khvcoqti	121	12	trial	trial	NN
cord-345762-khvcoqti	121	13	for	for	IN
cord-345762-khvcoqti	121	14	community	community	NN
cord-345762-khvcoqti	121	15	-	-	HYPH
cord-345762-khvcoqti	121	16	acquired	acquire	VBN
cord-345762-khvcoqti	121	17	pneumonia	pneumonia	NN
cord-345762-khvcoqti	121	18	(	(	-LRB-
cord-345762-khvcoqti	121	19	RE	RE	NNP
cord-345762-khvcoqti	121	20	-	-	HYPH
cord-345762-khvcoqti	121	21	MAP	MAP	NNP
cord-345762-khvcoqti	121	22	)	)	-RRB-
cord-345762-khvcoqti	121	23	University	University	NNP
cord-345762-khvcoqti	121	24	of	of	IN
cord-345762-khvcoqti	121	25	Oxford	Oxford	NNP
cord-345762-khvcoqti	121	26	Nuffield	Nuffield	NNP
cord-345762-khvcoqti	121	27	Department	Department	NNP
cord-345762-khvcoqti	121	28	of	of	IN
cord-345762-khvcoqti	121	29	Population	Population	NNP
cord-345762-khvcoqti	121	30	Health	Health	NNP
cord-345762-khvcoqti	121	31	.	.	.
cord-345762-khvcoqti	122	1	Randomised	randomised	JJ
cord-345762-khvcoqti	122	2	evaluation	evaluation	NN
cord-345762-khvcoqti	122	3	of	of	IN
cord-345762-khvcoqti	122	4	COVID-19	COVID-19	NNP
cord-345762-khvcoqti	122	5	therapy	therapy	NN
cord-345762-khvcoqti	122	6	(	(	-LRB-
cord-345762-khvcoqti	122	7	RECOVERY	recovery	NN
cord-345762-khvcoqti	122	8	)	)	-RRB-
cord-345762-khvcoqti	123	1	Minimal	minimal	JJ
cord-345762-khvcoqti	123	2	clinically	clinically	RB
cord-345762-khvcoqti	123	3	important	important	JJ
cord-345762-khvcoqti	123	4	difference	difference	NN
cord-345762-khvcoqti	123	5	:	:	:
cord-345762-khvcoqti	123	6	defining	define	VBG
cord-345762-khvcoqti	123	7	what	what	WP
cord-345762-khvcoqti	123	8	really	really	RB
cord-345762-khvcoqti	123	9	matters	matter	VBZ
cord-345762-khvcoqti	123	10	to	to	IN
cord-345762-khvcoqti	123	11	patients	patient	NNS
cord-345762-khvcoqti	123	12	Accelerating	accelerate	VBG
cord-345762-khvcoqti	123	13	COVID-19	covid-19	JJ
cord-345762-khvcoqti	123	14	therapeutic	therapeutic	JJ
cord-345762-khvcoqti	123	15	interventions	intervention	NNS
cord-345762-khvcoqti	123	16	and	and	CC
cord-345762-khvcoqti	123	17	vaccines	vaccine	NNS
cord-345762-khvcoqti	123	18	(	(	-LRB-
cord-345762-khvcoqti	123	19	ACTIV	ACTIV	NNP
cord-345762-khvcoqti	123	20	)	)	-RRB-
cord-345762-khvcoqti	123	21	.	.	.
cord-345762-khvcoqti	124	1	An	an	DT
cord-345762-khvcoqti	124	2	unprecedented	unprecedented	JJ
cord-345762-khvcoqti	124	3	partnership	partnership	NN
cord-345762-khvcoqti	124	4	for	for	IN
cord-345762-khvcoqti	124	5	unprecedented	unprecedented	JJ
cord-345762-khvcoqti	124	6	times	time	NNS
cord-345762-khvcoqti	124	7	What	what	WP
cord-345762-khvcoqti	124	8	the	the	DT
cord-345762-khvcoqti	124	9	public	public	JJ
cord-345762-khvcoqti	124	10	think	think	VBP
cord-345762-khvcoqti	124	11	about	about	IN
cord-345762-khvcoqti	124	12	participation	participation	NN
cord-345762-khvcoqti	124	13	in	in	IN
cord-345762-khvcoqti	124	14	medical	medical	JJ
cord-345762-khvcoqti	124	15	research	research	NN
cord-345762-khvcoqti	124	16	during	during	IN
cord-345762-khvcoqti	124	17	an	an	DT
cord-345762-khvcoqti	124	18	influenza	influenza	NN
cord-345762-khvcoqti	124	19	pandemic	pandemic	NN
cord-345762-khvcoqti	124	20	:	:	:
cord-345762-khvcoqti	124	21	an	an	DT
cord-345762-khvcoqti	124	22	international	international	JJ
cord-345762-khvcoqti	124	23	crosssectional	crosssectional	JJ
cord-345762-khvcoqti	124	24	survey	survey	NN