id sid tid token lemma pos cord-342776-hkjhqgie 1 1 key key NNP cord-342776-hkjhqgie 1 2 : : : cord-342776-hkjhqgie 1 3 cord-342776-hkjhqgie cord-342776-hkjhqgie NNP cord-342776-hkjhqgie 1 4 authors author NNS cord-342776-hkjhqgie 1 5 : : : cord-342776-hkjhqgie 1 6 Jewett Jewett NNP cord-342776-hkjhqgie 1 7 , , , cord-342776-hkjhqgie 1 8 Anahid Anahid NNP cord-342776-hkjhqgie 1 9 title title NN cord-342776-hkjhqgie 1 10 : : : cord-342776-hkjhqgie 1 11 The the DT cord-342776-hkjhqgie 1 12 Potential Potential NNP cord-342776-hkjhqgie 1 13 Effect Effect NNP cord-342776-hkjhqgie 1 14 of of IN cord-342776-hkjhqgie 1 15 Novel Novel NNP cord-342776-hkjhqgie 1 16 Coronavirus Coronavirus NNP cord-342776-hkjhqgie 1 17 SARS SARS NNP cord-342776-hkjhqgie 1 18 - - HYPH cord-342776-hkjhqgie 1 19 CoV-2 CoV-2 NNP cord-342776-hkjhqgie 1 20 on on IN cord-342776-hkjhqgie 1 21 NK NK NNP cord-342776-hkjhqgie 1 22 Cells Cells NNPS cord-342776-hkjhqgie 1 23 ; ; : cord-342776-hkjhqgie 1 24 A a DT cord-342776-hkjhqgie 1 25 Perspective perspective NN cord-342776-hkjhqgie 1 26 on on IN cord-342776-hkjhqgie 1 27 Potential potential JJ cord-342776-hkjhqgie 1 28 Therapeutic therapeutic JJ cord-342776-hkjhqgie 1 29 Interventions Interventions NNPS cord-342776-hkjhqgie 1 30 date date NN cord-342776-hkjhqgie 1 31 : : : cord-342776-hkjhqgie 1 32 2020 2020 CD cord-342776-hkjhqgie 1 33 - - HYPH cord-342776-hkjhqgie 1 34 07 07 CD cord-342776-hkjhqgie 1 35 - - SYM cord-342776-hkjhqgie 1 36 10 10 CD cord-342776-hkjhqgie 1 37 journal journal NN cord-342776-hkjhqgie 1 38 : : : cord-342776-hkjhqgie 2 1 Front Front NNP cord-342776-hkjhqgie 2 2 Immunol Immunol NNP cord-342776-hkjhqgie 2 3 DOI doi NN cord-342776-hkjhqgie 2 4 : : : cord-342776-hkjhqgie 3 1 10.3389 10.3389 CD cord-342776-hkjhqgie 4 1 /fimmu.2020.01692 /fimmu.2020.01692 NFP cord-342776-hkjhqgie 4 2 sha sha NNP cord-342776-hkjhqgie 4 3 : : : cord-342776-hkjhqgie 5 1 335f466d46cdfcda0630c85a99dd7c3b0efc1dc5 335f466d46cdfcda0630c85a99dd7c3b0efc1dc5 NNP cord-342776-hkjhqgie 5 2 doc_id doc_id NNP cord-342776-hkjhqgie 5 3 : : : cord-342776-hkjhqgie 5 4 342776 342776 CD cord-342776-hkjhqgie 5 5 cord_uid cord_uid NNS cord-342776-hkjhqgie 5 6 : : : cord-342776-hkjhqgie 5 7 hkjhqgie hkjhqgie NNP cord-342776-hkjhqgie 5 8 Coronavirus Coronavirus NNP cord-342776-hkjhqgie 5 9 - - HYPH cord-342776-hkjhqgie 5 10 induced induce VBN cord-342776-hkjhqgie 5 11 disease-2019 disease-2019 NNP cord-342776-hkjhqgie 6 1 ( ( -LRB- cord-342776-hkjhqgie 6 2 COVID-19 COVID-19 NNP cord-342776-hkjhqgie 6 3 ) ) -RRB- cord-342776-hkjhqgie 6 4 continues continue VBZ cord-342776-hkjhqgie 6 5 to to TO cord-342776-hkjhqgie 6 6 cause cause VB cord-342776-hkjhqgie 6 7 significant significant JJ cord-342776-hkjhqgie 6 8 morbidity morbidity NN cord-342776-hkjhqgie 6 9 and and CC cord-342776-hkjhqgie 6 10 mortality mortality NN cord-342776-hkjhqgie 6 11 worldwide worldwide RB cord-342776-hkjhqgie 6 12 . . . cord-342776-hkjhqgie 7 1 While while IN cord-342776-hkjhqgie 7 2 studies study NNS cord-342776-hkjhqgie 7 3 on on IN cord-342776-hkjhqgie 7 4 SARS SARS NNP cord-342776-hkjhqgie 7 5 - - HYPH cord-342776-hkjhqgie 7 6 CoV-2 CoV-2 NNP cord-342776-hkjhqgie 7 7 effects effect NNS cord-342776-hkjhqgie 7 8 on on IN cord-342776-hkjhqgie 7 9 immune immune JJ cord-342776-hkjhqgie 7 10 cell cell NN cord-342776-hkjhqgie 7 11 function function NN cord-342776-hkjhqgie 7 12 continue continue VBP cord-342776-hkjhqgie 7 13 to to TO cord-342776-hkjhqgie 7 14 progress progress VB cord-342776-hkjhqgie 7 15 , , , cord-342776-hkjhqgie 7 16 we -PRON- PRP cord-342776-hkjhqgie 7 17 know know VBP cord-342776-hkjhqgie 7 18 very very RB cord-342776-hkjhqgie 7 19 little little JJ cord-342776-hkjhqgie 7 20 about about IN cord-342776-hkjhqgie 7 21 the the DT cord-342776-hkjhqgie 7 22 significance significance NN cord-342776-hkjhqgie 7 23 of of IN cord-342776-hkjhqgie 7 24 depletion depletion NN cord-342776-hkjhqgie 7 25 of of IN cord-342776-hkjhqgie 7 26 key key JJ cord-342776-hkjhqgie 7 27 immune immune JJ cord-342776-hkjhqgie 7 28 effectors effector NNS cord-342776-hkjhqgie 7 29 by by IN cord-342776-hkjhqgie 7 30 the the DT cord-342776-hkjhqgie 7 31 virus virus NN cord-342776-hkjhqgie 7 32 in in IN cord-342776-hkjhqgie 7 33 the the DT cord-342776-hkjhqgie 7 34 mortality mortality NN cord-342776-hkjhqgie 7 35 and and CC cord-342776-hkjhqgie 7 36 morbidity morbidity NN cord-342776-hkjhqgie 7 37 of of IN cord-342776-hkjhqgie 7 38 the the DT cord-342776-hkjhqgie 7 39 disease disease NN cord-342776-hkjhqgie 7 40 . . . cord-342776-hkjhqgie 8 1 This this DT cord-342776-hkjhqgie 8 2 commentary commentary NN cord-342776-hkjhqgie 8 3 outlines outline VBZ cord-342776-hkjhqgie 8 4 what what WP cord-342776-hkjhqgie 8 5 is be VBZ cord-342776-hkjhqgie 8 6 the the DT cord-342776-hkjhqgie 8 7 reported report VBN cord-342776-hkjhqgie 8 8 literature literature NN cord-342776-hkjhqgie 8 9 thus thus RB cord-342776-hkjhqgie 8 10 far far RB cord-342776-hkjhqgie 8 11 on on IN cord-342776-hkjhqgie 8 12 the the DT cord-342776-hkjhqgie 8 13 effect effect NN cord-342776-hkjhqgie 8 14 of of IN cord-342776-hkjhqgie 8 15 virus virus NN cord-342776-hkjhqgie 8 16 on on IN cord-342776-hkjhqgie 8 17 NK NK NNP cord-342776-hkjhqgie 8 18 cells cell NNS cord-342776-hkjhqgie 8 19 known know VBN cord-342776-hkjhqgie 8 20 to to TO cord-342776-hkjhqgie 8 21 kill kill VB cord-342776-hkjhqgie 8 22 virally virally RB cord-342776-hkjhqgie 8 23 infected infect VBN cord-342776-hkjhqgie 8 24 cells cell NNS cord-342776-hkjhqgie 8 25 . . . cord-342776-hkjhqgie 9 1 It -PRON- PRP cord-342776-hkjhqgie 9 2 also also RB cord-342776-hkjhqgie 9 3 underscores underscore VBZ cord-342776-hkjhqgie 9 4 the the DT cord-342776-hkjhqgie 9 5 necessity necessity NN cord-342776-hkjhqgie 9 6 for for IN cord-342776-hkjhqgie 9 7 the the DT cord-342776-hkjhqgie 9 8 future future JJ cord-342776-hkjhqgie 9 9 comprehensive comprehensive JJ cord-342776-hkjhqgie 9 10 studies study NNS cord-342776-hkjhqgie 9 11 of of IN cord-342776-hkjhqgie 9 12 NK NK NNP cord-342776-hkjhqgie 9 13 cells cell NNS cord-342776-hkjhqgie 9 14 in in IN cord-342776-hkjhqgie 9 15 SARS SARS NNP cord-342776-hkjhqgie 9 16 - - HYPH cord-342776-hkjhqgie 9 17 CoV-2 CoV-2 NNP cord-342776-hkjhqgie 9 18 infected infect VBN cord-342776-hkjhqgie 9 19 individuals individual NNS cord-342776-hkjhqgie 9 20 and and CC cord-342776-hkjhqgie 9 21 animal animal NN cord-342776-hkjhqgie 9 22 models model NNS cord-342776-hkjhqgie 9 23 to to TO cord-342776-hkjhqgie 9 24 better better RB cord-342776-hkjhqgie 9 25 understand understand VB cord-342776-hkjhqgie 9 26 the the DT cord-342776-hkjhqgie 9 27 role role NN cord-342776-hkjhqgie 9 28 and and CC cord-342776-hkjhqgie 9 29 significance significance NN cord-342776-hkjhqgie 9 30 of of IN cord-342776-hkjhqgie 9 31 reported report VBN cord-342776-hkjhqgie 9 32 NK NK NNP cord-342776-hkjhqgie 9 33 cell cell NN cord-342776-hkjhqgie 9 34 depletion depletion NN cord-342776-hkjhqgie 9 35 and and CC cord-342776-hkjhqgie 9 36 functional functional JJ cord-342776-hkjhqgie 9 37 inactivation inactivation NN cord-342776-hkjhqgie 9 38 in in IN cord-342776-hkjhqgie 9 39 disease disease NN cord-342776-hkjhqgie 9 40 morbidity morbidity NN cord-342776-hkjhqgie 9 41 and and CC cord-342776-hkjhqgie 9 42 mortality mortality NN cord-342776-hkjhqgie 9 43 , , , cord-342776-hkjhqgie 9 44 in in IN cord-342776-hkjhqgie 9 45 hope hope NN cord-342776-hkjhqgie 9 46 to to TO cord-342776-hkjhqgie 9 47 design design VB cord-342776-hkjhqgie 9 48 effective effective JJ cord-342776-hkjhqgie 9 49 therapeutic therapeutic JJ cord-342776-hkjhqgie 9 50 interventions intervention NNS cord-342776-hkjhqgie 9 51 for for IN cord-342776-hkjhqgie 9 52 the the DT cord-342776-hkjhqgie 9 53 disease disease NN cord-342776-hkjhqgie 9 54 . . . cord-342776-hkjhqgie 10 1 Coronavirus Coronavirus NNP cord-342776-hkjhqgie 10 2 - - HYPH cord-342776-hkjhqgie 10 3 induced induce VBN cord-342776-hkjhqgie 10 4 disease-2019 disease-2019 NNP cord-342776-hkjhqgie 10 5 ( ( -LRB- cord-342776-hkjhqgie 10 6 COVID-19 COVID-19 NNP cord-342776-hkjhqgie 10 7 ) ) -RRB- cord-342776-hkjhqgie 10 8 poses pose VBZ cord-342776-hkjhqgie 10 9 a a DT cord-342776-hkjhqgie 10 10 great great JJ cord-342776-hkjhqgie 10 11 public public JJ cord-342776-hkjhqgie 10 12 health health NN cord-342776-hkjhqgie 10 13 threat threat NN cord-342776-hkjhqgie 10 14 , , , cord-342776-hkjhqgie 10 15 and and CC cord-342776-hkjhqgie 10 16 presents present VBZ cord-342776-hkjhqgie 10 17 a a DT cord-342776-hkjhqgie 10 18 complex complex JJ cord-342776-hkjhqgie 10 19 challenge challenge NN cord-342776-hkjhqgie 10 20 for for IN cord-342776-hkjhqgie 10 21 epidemiologists epidemiologist NNS cord-342776-hkjhqgie 10 22 and and CC cord-342776-hkjhqgie 10 23 public public JJ cord-342776-hkjhqgie 10 24 health health NN cord-342776-hkjhqgie 10 25 professionals professional NNS cord-342776-hkjhqgie 10 26 around around IN cord-342776-hkjhqgie 10 27 the the DT cord-342776-hkjhqgie 10 28 planet planet NN cord-342776-hkjhqgie 10 29 , , , cord-342776-hkjhqgie 10 30 as as IN cord-342776-hkjhqgie 10 31 the the DT cord-342776-hkjhqgie 10 32 disease disease NN cord-342776-hkjhqgie 10 33 has have VBZ cord-342776-hkjhqgie 10 34 shifted shift VBN cord-342776-hkjhqgie 10 35 from from IN cord-342776-hkjhqgie 10 36 a a DT cord-342776-hkjhqgie 10 37 regional regional JJ cord-342776-hkjhqgie 10 38 epidemic epidemic NN cord-342776-hkjhqgie 10 39 to to IN cord-342776-hkjhqgie 10 40 a a DT cord-342776-hkjhqgie 10 41 worldwide worldwide JJ cord-342776-hkjhqgie 10 42 pandemic pandemic NN cord-342776-hkjhqgie 10 43 in in IN cord-342776-hkjhqgie 10 44 a a DT cord-342776-hkjhqgie 10 45 short short JJ cord-342776-hkjhqgie 10 46 period period NN cord-342776-hkjhqgie 10 47 of of IN cord-342776-hkjhqgie 10 48 time time NN cord-342776-hkjhqgie 10 49 . . . cord-342776-hkjhqgie 11 1 The the DT cord-342776-hkjhqgie 11 2 toll toll NN cord-342776-hkjhqgie 11 3 that that WDT cord-342776-hkjhqgie 11 4 the the DT cord-342776-hkjhqgie 11 5 disease disease NN cord-342776-hkjhqgie 11 6 has have VBZ cord-342776-hkjhqgie 11 7 had have VBN cord-342776-hkjhqgie 11 8 on on IN cord-342776-hkjhqgie 11 9 the the DT cord-342776-hkjhqgie 11 10 global global JJ cord-342776-hkjhqgie 11 11 level level NN cord-342776-hkjhqgie 11 12 continues continue VBZ cord-342776-hkjhqgie 11 13 to to TO cord-342776-hkjhqgie 11 14 increase increase VB cord-342776-hkjhqgie 11 15 as as IN cord-342776-hkjhqgie 11 16 the the DT cord-342776-hkjhqgie 11 17 virus virus NN cord-342776-hkjhqgie 11 18 reaches reach VBZ cord-342776-hkjhqgie 11 19 all all DT cord-342776-hkjhqgie 11 20 continents continent NNS cord-342776-hkjhqgie 11 21 , , , cord-342776-hkjhqgie 11 22 except except IN cord-342776-hkjhqgie 11 23 Antarctica Antarctica NNP cord-342776-hkjhqgie 11 24 , , , cord-342776-hkjhqgie 11 25 afflicting afflict VBG cord-342776-hkjhqgie 11 26 more more JJR cord-342776-hkjhqgie 11 27 than than IN cord-342776-hkjhqgie 11 28 180 180 CD cord-342776-hkjhqgie 11 29 countries country NNS cord-342776-hkjhqgie 11 30 . . . cord-342776-hkjhqgie 12 1 Initial initial JJ cord-342776-hkjhqgie 12 2 reports report NNS cord-342776-hkjhqgie 12 3 of of IN cord-342776-hkjhqgie 12 4 COVID-19 COVID-19 NNP cord-342776-hkjhqgie 12 5 disease disease NN cord-342776-hkjhqgie 12 6 came come VBD cord-342776-hkjhqgie 12 7 from from IN cord-342776-hkjhqgie 12 8 Wuhan Wuhan NNP cord-342776-hkjhqgie 12 9 , , , cord-342776-hkjhqgie 12 10 China China NNP cord-342776-hkjhqgie 12 11 in in IN cord-342776-hkjhqgie 12 12 late late JJ cord-342776-hkjhqgie 12 13 December December NNP cord-342776-hkjhqgie 12 14 2019 2019 CD cord-342776-hkjhqgie 12 15 , , , cord-342776-hkjhqgie 12 16 as as IN cord-342776-hkjhqgie 12 17 patients patient NNS cord-342776-hkjhqgie 12 18 began begin VBD cord-342776-hkjhqgie 12 19 complaining complain VBG cord-342776-hkjhqgie 12 20 about about IN cord-342776-hkjhqgie 12 21 unexplained unexplained JJ cord-342776-hkjhqgie 12 22 respiratory respiratory JJ cord-342776-hkjhqgie 12 23 infections infection NNS cord-342776-hkjhqgie 12 24 , , , cord-342776-hkjhqgie 12 25 which which WDT cord-342776-hkjhqgie 12 26 later later RB cord-342776-hkjhqgie 12 27 was be VBD cord-342776-hkjhqgie 12 28 coined coin VBN cord-342776-hkjhqgie 12 29 as as IN cord-342776-hkjhqgie 12 30 " " `` cord-342776-hkjhqgie 12 31 pneumonia pneumonia NN cord-342776-hkjhqgie 12 32 of of IN cord-342776-hkjhqgie 12 33 unknown unknown JJ cord-342776-hkjhqgie 12 34 etiology etiology NN cord-342776-hkjhqgie 12 35 " " '' cord-342776-hkjhqgie 12 36 ( ( -LRB- cord-342776-hkjhqgie 12 37 1 1 CD cord-342776-hkjhqgie 12 38 ) ) -RRB- cord-342776-hkjhqgie 12 39 . . . cord-342776-hkjhqgie 13 1 Shortly shortly RB cord-342776-hkjhqgie 13 2 after after IN cord-342776-hkjhqgie 13 3 surfacing surface VBG cord-342776-hkjhqgie 13 4 of of IN cord-342776-hkjhqgie 13 5 the the DT cord-342776-hkjhqgie 13 6 virus virus NN cord-342776-hkjhqgie 13 7 several several JJ cord-342776-hkjhqgie 13 8 independent independent JJ cord-342776-hkjhqgie 13 9 laboratories laboratory NNS cord-342776-hkjhqgie 13 10 identified identify VBD cord-342776-hkjhqgie 13 11 the the DT cord-342776-hkjhqgie 13 12 causative causative JJ cord-342776-hkjhqgie 13 13 agent agent NN cord-342776-hkjhqgie 13 14 of of IN cord-342776-hkjhqgie 13 15 COVID-19 COVID-19 NNP cord-342776-hkjhqgie 13 16 disease disease NN cord-342776-hkjhqgie 13 17 , , , cord-342776-hkjhqgie 13 18 ultimately ultimately RB cord-342776-hkjhqgie 13 19 naming name VBG cord-342776-hkjhqgie 13 20 it -PRON- PRP cord-342776-hkjhqgie 13 21 as as IN cord-342776-hkjhqgie 13 22 severe severe JJ cord-342776-hkjhqgie 13 23 acute acute JJ cord-342776-hkjhqgie 13 24 respiratory respiratory JJ cord-342776-hkjhqgie 13 25 syndrome syndrome NN cord-342776-hkjhqgie 13 26 coronavirus coronavirus NN cord-342776-hkjhqgie 13 27 2 2 CD cord-342776-hkjhqgie 14 1 ( ( -LRB- cord-342776-hkjhqgie 14 2 SARS SARS NNP cord-342776-hkjhqgie 14 3 - - HYPH cord-342776-hkjhqgie 14 4 CoV-2 CoV-2 NNP cord-342776-hkjhqgie 14 5 ) ) -RRB- cord-342776-hkjhqgie 15 1 ( ( -LRB- cord-342776-hkjhqgie 15 2 2 2 CD cord-342776-hkjhqgie 15 3 , , , cord-342776-hkjhqgie 15 4 3 3 CD cord-342776-hkjhqgie 15 5 ) ) -RRB- cord-342776-hkjhqgie 15 6 . . . cord-342776-hkjhqgie 16 1 While while IN cord-342776-hkjhqgie 16 2 the the DT cord-342776-hkjhqgie 16 3 search search NN cord-342776-hkjhqgie 16 4 is be VBZ cord-342776-hkjhqgie 16 5 continuing continue VBG cord-342776-hkjhqgie 16 6 to to TO cord-342776-hkjhqgie 16 7 uncover uncover VB cord-342776-hkjhqgie 16 8 the the DT cord-342776-hkjhqgie 16 9 infectious infectious JJ cord-342776-hkjhqgie 16 10 path path NN cord-342776-hkjhqgie 16 11 of of IN cord-342776-hkjhqgie 16 12 SARS SARS NNP cord-342776-hkjhqgie 16 13 - - HYPH cord-342776-hkjhqgie 16 14 CoV-2 CoV-2 NNP cord-342776-hkjhqgie 16 15 , , , cord-342776-hkjhqgie 16 16 several several JJ cord-342776-hkjhqgie 16 17 key key JJ cord-342776-hkjhqgie 16 18 findings finding NNS cord-342776-hkjhqgie 16 19 have have VBP cord-342776-hkjhqgie 16 20 led lead VBN cord-342776-hkjhqgie 16 21 the the DT cord-342776-hkjhqgie 16 22 infectious infectious JJ cord-342776-hkjhqgie 16 23 disease disease NN cord-342776-hkjhqgie 16 24 experts expert NNS cord-342776-hkjhqgie 16 25 to to TO cord-342776-hkjhqgie 16 26 partly partly RB cord-342776-hkjhqgie 16 27 uncover uncover VB cord-342776-hkjhqgie 16 28 the the DT cord-342776-hkjhqgie 16 29 mechanisms mechanism NNS cord-342776-hkjhqgie 16 30 of of IN cord-342776-hkjhqgie 16 31 the the DT cord-342776-hkjhqgie 16 32 original original JJ cord-342776-hkjhqgie 16 33 spread spread NN cord-342776-hkjhqgie 16 34 to to IN cord-342776-hkjhqgie 16 35 humans human NNS cord-342776-hkjhqgie 16 36 . . . cord-342776-hkjhqgie 17 1 By by IN cord-342776-hkjhqgie 17 2 phylogenetically phylogenetically RB cord-342776-hkjhqgie 17 3 comparing compare VBG cord-342776-hkjhqgie 17 4 SARS SARS NNP cord-342776-hkjhqgie 17 5 - - HYPH cord-342776-hkjhqgie 17 6 CoV-2 CoV-2 NNP cord-342776-hkjhqgie 17 7 to to IN cord-342776-hkjhqgie 17 8 other other JJ cord-342776-hkjhqgie 17 9 coronaviruses coronaviruse NNS cord-342776-hkjhqgie 17 10 , , , cord-342776-hkjhqgie 17 11 it -PRON- PRP cord-342776-hkjhqgie 17 12 was be VBD cord-342776-hkjhqgie 17 13 noted note VBN cord-342776-hkjhqgie 17 14 that that IN cord-342776-hkjhqgie 17 15 the the DT cord-342776-hkjhqgie 17 16 new new JJ cord-342776-hkjhqgie 17 17 virus virus NN cord-342776-hkjhqgie 17 18 was be VBD cord-342776-hkjhqgie 17 19 highly highly RB cord-342776-hkjhqgie 17 20 identical identical JJ cord-342776-hkjhqgie 17 21 to to IN cord-342776-hkjhqgie 17 22 other other JJ cord-342776-hkjhqgie 17 23 coronaviruses coronaviruse NNS cord-342776-hkjhqgie 17 24 that that WDT cord-342776-hkjhqgie 17 25 had have VBD cord-342776-hkjhqgie 17 26 originated originate VBN cord-342776-hkjhqgie 17 27 from from IN cord-342776-hkjhqgie 17 28 bats bat NNS cord-342776-hkjhqgie 17 29 ( ( -LRB- cord-342776-hkjhqgie 17 30 3 3 CD cord-342776-hkjhqgie 17 31 , , , cord-342776-hkjhqgie 17 32 4 4 CD cord-342776-hkjhqgie 17 33 ) ) -RRB- cord-342776-hkjhqgie 17 34 . . . cord-342776-hkjhqgie 18 1 However however RB cord-342776-hkjhqgie 18 2 , , , cord-342776-hkjhqgie 18 3 to to TO cord-342776-hkjhqgie 18 4 date date NN cord-342776-hkjhqgie 18 5 the the DT cord-342776-hkjhqgie 18 6 complete complete JJ cord-342776-hkjhqgie 18 7 transmission transmission NN cord-342776-hkjhqgie 18 8 route route NN cord-342776-hkjhqgie 18 9 remains remain VBZ cord-342776-hkjhqgie 18 10 elusive elusive JJ cord-342776-hkjhqgie 18 11 . . . cord-342776-hkjhqgie 19 1 Despite despite IN cord-342776-hkjhqgie 19 2 the the DT cord-342776-hkjhqgie 19 3 novelty novelty NN cord-342776-hkjhqgie 19 4 of of IN cord-342776-hkjhqgie 19 5 this this DT cord-342776-hkjhqgie 19 6 particular particular JJ cord-342776-hkjhqgie 19 7 strain strain NN cord-342776-hkjhqgie 19 8 of of IN cord-342776-hkjhqgie 19 9 coronavirus coronavirus NN cord-342776-hkjhqgie 19 10 , , , cord-342776-hkjhqgie 19 11 the the DT cord-342776-hkjhqgie 19 12 SARS SARS NNP cord-342776-hkjhqgie 19 13 - - HYPH cord-342776-hkjhqgie 19 14 CoV-2 CoV-2 NNP cord-342776-hkjhqgie 19 15 is be VBZ cord-342776-hkjhqgie 19 16 not not RB cord-342776-hkjhqgie 19 17 without without IN cord-342776-hkjhqgie 19 18 precedent precedent NN cord-342776-hkjhqgie 19 19 . . . cord-342776-hkjhqgie 20 1 Outbreaks outbreak NNS cord-342776-hkjhqgie 20 2 in in IN cord-342776-hkjhqgie 20 3 the the DT cord-342776-hkjhqgie 20 4 past past JJ cord-342776-hkjhqgie 20 5 decades decade NNS cord-342776-hkjhqgie 20 6 , , , cord-342776-hkjhqgie 20 7 such such JJ cord-342776-hkjhqgie 20 8 as as IN cord-342776-hkjhqgie 20 9 severe severe JJ cord-342776-hkjhqgie 20 10 acute acute JJ cord-342776-hkjhqgie 20 11 respiratory respiratory JJ cord-342776-hkjhqgie 20 12 syndrome syndrome NN cord-342776-hkjhqgie 20 13 ( ( -LRB- cord-342776-hkjhqgie 20 14 SARS SARS NNP cord-342776-hkjhqgie 20 15 ) ) -RRB- cord-342776-hkjhqgie 20 16 and and CC cord-342776-hkjhqgie 20 17 Middle Middle NNP cord-342776-hkjhqgie 20 18 East East NNP cord-342776-hkjhqgie 20 19 respiratory respiratory JJ cord-342776-hkjhqgie 20 20 syndrome syndrome NN cord-342776-hkjhqgie 20 21 ( ( -LRB- cord-342776-hkjhqgie 20 22 MERS MERS NNP cord-342776-hkjhqgie 20 23 ) ) -RRB- cord-342776-hkjhqgie 20 24 , , , cord-342776-hkjhqgie 20 25 identified identify VBD cord-342776-hkjhqgie 20 26 viruses virus NNS cord-342776-hkjhqgie 20 27 that that WDT cord-342776-hkjhqgie 20 28 fall fall VBP cord-342776-hkjhqgie 20 29 into into IN cord-342776-hkjhqgie 20 30 the the DT cord-342776-hkjhqgie 20 31 same same JJ cord-342776-hkjhqgie 20 32 category category NN cord-342776-hkjhqgie 20 33 of of IN cord-342776-hkjhqgie 20 34 coronaviruses coronaviruse NNS cord-342776-hkjhqgie 20 35 , , , cord-342776-hkjhqgie 20 36 which which WDT cord-342776-hkjhqgie 20 37 are be VBP cord-342776-hkjhqgie 20 38 single single RB cord-342776-hkjhqgie 20 39 - - HYPH cord-342776-hkjhqgie 20 40 stranded strand VBN cord-342776-hkjhqgie 20 41 RNA RNA NNP cord-342776-hkjhqgie 20 42 viruses virus NNS cord-342776-hkjhqgie 20 43 ( ( -LRB- cord-342776-hkjhqgie 20 44 + + CC cord-342776-hkjhqgie 20 45 ssRNA ssrna NN cord-342776-hkjhqgie 20 46 ) ) -RRB- cord-342776-hkjhqgie 20 47 that that WDT cord-342776-hkjhqgie 20 48 morphologically morphologically RB cord-342776-hkjhqgie 20 49 have have VBP cord-342776-hkjhqgie 20 50 been be VBN cord-342776-hkjhqgie 20 51 determined determine VBN cord-342776-hkjhqgie 20 52 to to TO cord-342776-hkjhqgie 20 53 express express VB cord-342776-hkjhqgie 20 54 crown crown NN cord-342776-hkjhqgie 20 55 - - HYPH cord-342776-hkjhqgie 20 56 like like JJ cord-342776-hkjhqgie 20 57 spikes spike NNS cord-342776-hkjhqgie 20 58 on on IN cord-342776-hkjhqgie 20 59 their -PRON- PRP$ cord-342776-hkjhqgie 20 60 surfaces surface NNS cord-342776-hkjhqgie 20 61 . . . cord-342776-hkjhqgie 21 1 However however RB cord-342776-hkjhqgie 21 2 , , , cord-342776-hkjhqgie 21 3 the the DT cord-342776-hkjhqgie 21 4 difference difference NN cord-342776-hkjhqgie 21 5 seen see VBN cord-342776-hkjhqgie 21 6 between between IN cord-342776-hkjhqgie 21 7 prior prior JJ cord-342776-hkjhqgie 21 8 species specie NNS cord-342776-hkjhqgie 21 9 of of IN cord-342776-hkjhqgie 21 10 coronaviruses coronaviruse NNS cord-342776-hkjhqgie 21 11 and and CC cord-342776-hkjhqgie 21 12 SARS SARS NNP cord-342776-hkjhqgie 21 13 - - : cord-342776-hkjhqgie 21 14 CoV-2 CoV-2 NNP cord-342776-hkjhqgie 21 15 partly partly RB cord-342776-hkjhqgie 21 16 lies lie VBZ cord-342776-hkjhqgie 21 17 in in IN cord-342776-hkjhqgie 21 18 their -PRON- PRP$ cord-342776-hkjhqgie 21 19 respective respective JJ cord-342776-hkjhqgie 21 20 symptom symptom NN cord-342776-hkjhqgie 21 21 presentations presentation NNS cord-342776-hkjhqgie 21 22 in in IN cord-342776-hkjhqgie 21 23 patients patient NNS cord-342776-hkjhqgie 21 24 . . . cord-342776-hkjhqgie 22 1 Compared compare VBN cord-342776-hkjhqgie 22 2 to to IN cord-342776-hkjhqgie 22 3 SARS SARS NNP cord-342776-hkjhqgie 22 4 and and CC cord-342776-hkjhqgie 22 5 MERS MERS NNP cord-342776-hkjhqgie 22 6 , , , cord-342776-hkjhqgie 22 7 the the DT cord-342776-hkjhqgie 22 8 symptoms symptom NNS cord-342776-hkjhqgie 22 9 of of IN cord-342776-hkjhqgie 22 10 COVID-19 COVID-19 NNP cord-342776-hkjhqgie 22 11 disease disease NN cord-342776-hkjhqgie 22 12 are be VBP cord-342776-hkjhqgie 22 13 not not RB cord-342776-hkjhqgie 22 14 presented present VBN cord-342776-hkjhqgie 22 15 earlier early RBR cord-342776-hkjhqgie 22 16 in in IN cord-342776-hkjhqgie 22 17 the the DT cord-342776-hkjhqgie 22 18 infectious infectious JJ cord-342776-hkjhqgie 22 19 cycle cycle NN cord-342776-hkjhqgie 22 20 , , , cord-342776-hkjhqgie 22 21 which which WDT cord-342776-hkjhqgie 22 22 may may MD cord-342776-hkjhqgie 22 23 be be VB cord-342776-hkjhqgie 22 24 a a DT cord-342776-hkjhqgie 22 25 reason reason NN cord-342776-hkjhqgie 22 26 for for IN cord-342776-hkjhqgie 22 27 the the DT cord-342776-hkjhqgie 22 28 greater great JJR cord-342776-hkjhqgie 22 29 ability ability NN cord-342776-hkjhqgie 22 30 of of IN cord-342776-hkjhqgie 22 31 viral viral JJ cord-342776-hkjhqgie 22 32 transmission transmission NN cord-342776-hkjhqgie 22 33 in in IN cord-342776-hkjhqgie 22 34 patients patient NNS cord-342776-hkjhqgie 22 35 ( ( -LRB- cord-342776-hkjhqgie 22 36 4 4 CD cord-342776-hkjhqgie 22 37 ) ) -RRB- cord-342776-hkjhqgie 22 38 . . . cord-342776-hkjhqgie 23 1 The the DT cord-342776-hkjhqgie 23 2 incubation incubation NN cord-342776-hkjhqgie 23 3 period period NN cord-342776-hkjhqgie 23 4 of of IN cord-342776-hkjhqgie 23 5 the the DT cord-342776-hkjhqgie 23 6 SARS SARS NNP cord-342776-hkjhqgie 23 7 - - HYPH cord-342776-hkjhqgie 23 8 CoV-2 CoV-2 NNP cord-342776-hkjhqgie 23 9 is be VBZ cord-342776-hkjhqgie 23 10 relatively relatively RB cord-342776-hkjhqgie 23 11 longer long JJR cord-342776-hkjhqgie 23 12 than than IN cord-342776-hkjhqgie 23 13 those those DT cord-342776-hkjhqgie 23 14 of of IN cord-342776-hkjhqgie 23 15 SARS SARS NNP cord-342776-hkjhqgie 23 16 and and CC cord-342776-hkjhqgie 23 17 MERs MERs NNPS cord-342776-hkjhqgie 23 18 ( ( -LRB- cord-342776-hkjhqgie 23 19 7 7 CD cord-342776-hkjhqgie 23 20 - - SYM cord-342776-hkjhqgie 23 21 14 14 CD cord-342776-hkjhqgie 23 22 days day NNS cord-342776-hkjhqgie 23 23 vs. vs. CC cord-342776-hkjhqgie 23 24 5.0 5.0 CD cord-342776-hkjhqgie 23 25 - - HYPH cord-342776-hkjhqgie 23 26 6.9 6.9 CD cord-342776-hkjhqgie 23 27 and and CC cord-342776-hkjhqgie 23 28 4.4 4.4 CD cord-342776-hkjhqgie 23 29 - - SYM cord-342776-hkjhqgie 23 30 6.9 6.9 CD cord-342776-hkjhqgie 23 31 , , , cord-342776-hkjhqgie 23 32 respectively respectively RB cord-342776-hkjhqgie 23 33 ) ) -RRB- cord-342776-hkjhqgie 24 1 ( ( -LRB- cord-342776-hkjhqgie 24 2 4 4 LS cord-342776-hkjhqgie 24 3 ) ) -RRB- cord-342776-hkjhqgie 24 4 . . . cord-342776-hkjhqgie 25 1 In in IN cord-342776-hkjhqgie 25 2 addition addition NN cord-342776-hkjhqgie 25 3 to to IN cord-342776-hkjhqgie 25 4 its -PRON- PRP$ cord-342776-hkjhqgie 25 5 longer long JJR cord-342776-hkjhqgie 25 6 incubation incubation NN cord-342776-hkjhqgie 25 7 period period NN cord-342776-hkjhqgie 25 8 , , , cord-342776-hkjhqgie 25 9 the the DT cord-342776-hkjhqgie 25 10 mean mean JJ cord-342776-hkjhqgie 25 11 reproductive reproductive JJ cord-342776-hkjhqgie 25 12 number number NN cord-342776-hkjhqgie 25 13 ( ( -LRB- cord-342776-hkjhqgie 25 14 R r NN cord-342776-hkjhqgie 25 15 0 0 CD cord-342776-hkjhqgie 25 16 ) ) -RRB- cord-342776-hkjhqgie 25 17 of of IN cord-342776-hkjhqgie 25 18 SARS SARS NNP cord-342776-hkjhqgie 25 19 - - HYPH cord-342776-hkjhqgie 25 20 CoV-2 CoV-2 NNP cord-342776-hkjhqgie 25 21 has have VBZ cord-342776-hkjhqgie 25 22 also also RB cord-342776-hkjhqgie 25 23 been be VBN cord-342776-hkjhqgie 25 24 estimated estimate VBN cord-342776-hkjhqgie 25 25 to to TO cord-342776-hkjhqgie 25 26 range range VB cord-342776-hkjhqgie 25 27 from from IN cord-342776-hkjhqgie 25 28 2.20 2.20 CD cord-342776-hkjhqgie 25 29 to to IN cord-342776-hkjhqgie 25 30 3.58 3.58 CD cord-342776-hkjhqgie 25 31 , , , cord-342776-hkjhqgie 25 32 indicating indicate VBG cord-342776-hkjhqgie 25 33 that that IN cord-342776-hkjhqgie 25 34 each each DT cord-342776-hkjhqgie 25 35 infected infected JJ cord-342776-hkjhqgie 25 36 patient patient NN cord-342776-hkjhqgie 25 37 can can MD cord-342776-hkjhqgie 25 38 on on IN cord-342776-hkjhqgie 25 39 average average JJ cord-342776-hkjhqgie 25 40 transmit transmit VB cord-342776-hkjhqgie 25 41 the the DT cord-342776-hkjhqgie 25 42 disease disease NN cord-342776-hkjhqgie 25 43 to to IN cord-342776-hkjhqgie 25 44 two two CD cord-342776-hkjhqgie 25 45 to to TO cord-342776-hkjhqgie 25 46 three three CD cord-342776-hkjhqgie 25 47 other other JJ cord-342776-hkjhqgie 25 48 individuals individual NNS cord-342776-hkjhqgie 25 49 ( ( -LRB- cord-342776-hkjhqgie 25 50 5 5 CD cord-342776-hkjhqgie 25 51 , , , cord-342776-hkjhqgie 25 52 6 6 CD cord-342776-hkjhqgie 25 53 ) ) -RRB- cord-342776-hkjhqgie 25 54 . . . cord-342776-hkjhqgie 26 1 According accord VBG cord-342776-hkjhqgie 26 2 to to IN cord-342776-hkjhqgie 26 3 the the DT cord-342776-hkjhqgie 26 4 available available JJ cord-342776-hkjhqgie 26 5 COVID-19 covid-19 JJ cord-342776-hkjhqgie 26 6 clinical clinical JJ cord-342776-hkjhqgie 26 7 data datum NNS cord-342776-hkjhqgie 26 8 , , , cord-342776-hkjhqgie 26 9 most most JJS cord-342776-hkjhqgie 26 10 patients patient NNS cord-342776-hkjhqgie 26 11 fall fall VBP cord-342776-hkjhqgie 26 12 into into IN cord-342776-hkjhqgie 26 13 the the DT cord-342776-hkjhqgie 26 14 range range NN cord-342776-hkjhqgie 26 15 of of IN cord-342776-hkjhqgie 26 16 30 30 CD cord-342776-hkjhqgie 26 17 - - SYM cord-342776-hkjhqgie 26 18 79 79 CD cord-342776-hkjhqgie 26 19 years year NNS cord-342776-hkjhqgie 26 20 of of IN cord-342776-hkjhqgie 26 21 age age NN cord-342776-hkjhqgie 26 22 , , , cord-342776-hkjhqgie 26 23 although although IN cord-342776-hkjhqgie 26 24 several several JJ cord-342776-hkjhqgie 26 25 cases case NNS cord-342776-hkjhqgie 26 26 have have VBP cord-342776-hkjhqgie 26 27 been be VBN cord-342776-hkjhqgie 26 28 identified identify VBN cord-342776-hkjhqgie 26 29 in in IN cord-342776-hkjhqgie 26 30 younger young JJR cord-342776-hkjhqgie 26 31 individuals individual NNS cord-342776-hkjhqgie 26 32 and and CC cord-342776-hkjhqgie 26 33 in in IN cord-342776-hkjhqgie 26 34 children child NNS cord-342776-hkjhqgie 26 35 recently recently RB cord-342776-hkjhqgie 26 36 ( ( -LRB- cord-342776-hkjhqgie 26 37 7 7 CD cord-342776-hkjhqgie 26 38 ) ) -RRB- cord-342776-hkjhqgie 26 39 . . . cord-342776-hkjhqgie 27 1 For for IN cord-342776-hkjhqgie 27 2 infected infected JJ cord-342776-hkjhqgie 27 3 patients patient NNS cord-342776-hkjhqgie 27 4 , , , cord-342776-hkjhqgie 27 5 severity severity NN cord-342776-hkjhqgie 27 6 of of IN cord-342776-hkjhqgie 27 7 symptoms symptom NNS cord-342776-hkjhqgie 27 8 has have VBZ cord-342776-hkjhqgie 27 9 been be VBN cord-342776-hkjhqgie 27 10 classified classify VBN cord-342776-hkjhqgie 27 11 as as IN cord-342776-hkjhqgie 27 12 mild mild JJ cord-342776-hkjhqgie 27 13 , , , cord-342776-hkjhqgie 27 14 severe severe JJ cord-342776-hkjhqgie 27 15 , , , cord-342776-hkjhqgie 27 16 and and CC cord-342776-hkjhqgie 27 17 critical critical JJ cord-342776-hkjhqgie 27 18 . . . cord-342776-hkjhqgie 28 1 This this DT cord-342776-hkjhqgie 28 2 spectrum spectrum NN cord-342776-hkjhqgie 28 3 of of IN cord-342776-hkjhqgie 28 4 disease disease NN cord-342776-hkjhqgie 28 5 widely widely RB cord-342776-hkjhqgie 28 6 varies vary VBZ cord-342776-hkjhqgie 28 7 , , , cord-342776-hkjhqgie 28 8 as as IN cord-342776-hkjhqgie 28 9 clinical clinical JJ cord-342776-hkjhqgie 28 10 presentation presentation NN cord-342776-hkjhqgie 28 11 in in IN cord-342776-hkjhqgie 28 12 infected infected JJ cord-342776-hkjhqgie 28 13 individuals individual NNS cord-342776-hkjhqgie 28 14 have have VBP cord-342776-hkjhqgie 28 15 ranged range VBN cord-342776-hkjhqgie 28 16 from from IN cord-342776-hkjhqgie 28 17 asymptomatic asymptomatic JJ cord-342776-hkjhqgie 28 18 infection infection NN cord-342776-hkjhqgie 28 19 to to IN cord-342776-hkjhqgie 28 20 severe severe JJ cord-342776-hkjhqgie 28 21 respiratory respiratory JJ cord-342776-hkjhqgie 28 22 failure failure NN cord-342776-hkjhqgie 28 23 ( ( -LRB- cord-342776-hkjhqgie 28 24 2 2 CD cord-342776-hkjhqgie 28 25 ) ) -RRB- cord-342776-hkjhqgie 28 26 . . . cord-342776-hkjhqgie 29 1 Asymptomatic asymptomatic JJ cord-342776-hkjhqgie 29 2 transmission transmission NN cord-342776-hkjhqgie 29 3 of of IN cord-342776-hkjhqgie 29 4 SARS SARS NNP cord-342776-hkjhqgie 29 5 - - HYPH cord-342776-hkjhqgie 29 6 CoV-2 CoV-2 NNP cord-342776-hkjhqgie 29 7 poses pose VBZ cord-342776-hkjhqgie 29 8 a a DT cord-342776-hkjhqgie 29 9 great great JJ cord-342776-hkjhqgie 29 10 public public JJ cord-342776-hkjhqgie 29 11 health health NN cord-342776-hkjhqgie 29 12 challenge challenge NN cord-342776-hkjhqgie 29 13 in in IN cord-342776-hkjhqgie 29 14 containment containment NN cord-342776-hkjhqgie 29 15 efforts effort NNS cord-342776-hkjhqgie 29 16 , , , cord-342776-hkjhqgie 29 17 as as IN cord-342776-hkjhqgie 29 18 previous previous JJ cord-342776-hkjhqgie 29 19 reports report NNS cord-342776-hkjhqgie 29 20 have have VBP cord-342776-hkjhqgie 29 21 noted note VBN cord-342776-hkjhqgie 29 22 as as RB cord-342776-hkjhqgie 29 23 much much JJ cord-342776-hkjhqgie 29 24 as as IN cord-342776-hkjhqgie 29 25 12.6 12.6 CD cord-342776-hkjhqgie 29 26 % % NN cord-342776-hkjhqgie 29 27 of of IN cord-342776-hkjhqgie 29 28 case case NN cord-342776-hkjhqgie 29 29 reports report NNS cord-342776-hkjhqgie 29 30 to to TO cord-342776-hkjhqgie 29 31 be be VB cord-342776-hkjhqgie 29 32 presymptomatic presymptomatic JJ cord-342776-hkjhqgie 29 33 transmission transmission NN cord-342776-hkjhqgie 29 34 ( ( -LRB- cord-342776-hkjhqgie 29 35 8) 8) NN cord-342776-hkjhqgie 29 36 . . . cord-342776-hkjhqgie 30 1 However however RB cord-342776-hkjhqgie 30 2 , , , cord-342776-hkjhqgie 30 3 the the DT cord-342776-hkjhqgie 30 4 main main JJ cord-342776-hkjhqgie 30 5 characteristic characteristic JJ cord-342776-hkjhqgie 30 6 symptoms symptom NNS cord-342776-hkjhqgie 30 7 of of IN cord-342776-hkjhqgie 30 8 COVID-19 COVID-19 NNP cord-342776-hkjhqgie 30 9 disease disease NN cord-342776-hkjhqgie 30 10 have have VBP cord-342776-hkjhqgie 30 11 included include VBN cord-342776-hkjhqgie 30 12 fevers fever NNS cord-342776-hkjhqgie 30 13 , , , cord-342776-hkjhqgie 30 14 fatigue fatigue NN cord-342776-hkjhqgie 30 15 , , , cord-342776-hkjhqgie 30 16 dry dry JJ cord-342776-hkjhqgie 30 17 cough cough NN cord-342776-hkjhqgie 30 18 and and CC cord-342776-hkjhqgie 30 19 respiratory respiratory JJ cord-342776-hkjhqgie 30 20 distress distress NN cord-342776-hkjhqgie 30 21 . . . cord-342776-hkjhqgie 31 1 The the DT cord-342776-hkjhqgie 31 2 number number NN cord-342776-hkjhqgie 31 3 of of IN cord-342776-hkjhqgie 31 4 SARS SARS NNP cord-342776-hkjhqgie 31 5 - - HYPH cord-342776-hkjhqgie 31 6 CoV-2 CoV-2 NNP cord-342776-hkjhqgie 31 7 infected infect VBN cord-342776-hkjhqgie 31 8 cases case NNS cord-342776-hkjhqgie 31 9 will will MD cord-342776-hkjhqgie 31 10 certainly certainly RB cord-342776-hkjhqgie 31 11 continue continue VB cord-342776-hkjhqgie 31 12 to to TO cord-342776-hkjhqgie 31 13 rise rise VB cord-342776-hkjhqgie 31 14 worldwide worldwide RB cord-342776-hkjhqgie 31 15 especially especially RB cord-342776-hkjhqgie 31 16 now now RB cord-342776-hkjhqgie 31 17 that that IN cord-342776-hkjhqgie 31 18 many many JJ cord-342776-hkjhqgie 31 19 countries country NNS cord-342776-hkjhqgie 31 20 have have VBP cord-342776-hkjhqgie 31 21 chosen choose VBN cord-342776-hkjhqgie 31 22 to to TO cord-342776-hkjhqgie 31 23 relax relax VB cord-342776-hkjhqgie 31 24 the the DT cord-342776-hkjhqgie 31 25 rules rule NNS cord-342776-hkjhqgie 31 26 of of IN cord-342776-hkjhqgie 31 27 social social JJ cord-342776-hkjhqgie 31 28 distancing distancing NN cord-342776-hkjhqgie 31 29 and and CC cord-342776-hkjhqgie 31 30 isolation isolation NN cord-342776-hkjhqgie 31 31 due due IN cord-342776-hkjhqgie 31 32 to to IN cord-342776-hkjhqgie 31 33 the the DT cord-342776-hkjhqgie 31 34 reopening reopening NN cord-342776-hkjhqgie 31 35 of of IN cord-342776-hkjhqgie 31 36 the the DT cord-342776-hkjhqgie 31 37 economy economy NN cord-342776-hkjhqgie 31 38 and and CC cord-342776-hkjhqgie 31 39 the the DT cord-342776-hkjhqgie 31 40 work work NN cord-342776-hkjhqgie 31 41 force force NN cord-342776-hkjhqgie 31 42 . . . cord-342776-hkjhqgie 32 1 One one CD cord-342776-hkjhqgie 32 2 of of IN cord-342776-hkjhqgie 32 3 the the DT cord-342776-hkjhqgie 32 4 most most RBS cord-342776-hkjhqgie 32 5 troubling troubling JJ cord-342776-hkjhqgie 32 6 factors factor NNS cord-342776-hkjhqgie 32 7 about about IN cord-342776-hkjhqgie 32 8 this this DT cord-342776-hkjhqgie 32 9 disease disease NN cord-342776-hkjhqgie 32 10 is be VBZ cord-342776-hkjhqgie 32 11 the the DT cord-342776-hkjhqgie 32 12 lack lack NN cord-342776-hkjhqgie 32 13 of of IN cord-342776-hkjhqgie 32 14 adequate adequate JJ cord-342776-hkjhqgie 32 15 understanding understanding NN cord-342776-hkjhqgie 32 16 of of IN cord-342776-hkjhqgie 32 17 the the DT cord-342776-hkjhqgie 32 18 virus virus NN cord-342776-hkjhqgie 32 19 and and CC cord-342776-hkjhqgie 32 20 the the DT cord-342776-hkjhqgie 32 21 mechanisms mechanism NNS cord-342776-hkjhqgie 32 22 by by IN cord-342776-hkjhqgie 32 23 which which WDT cord-342776-hkjhqgie 32 24 it -PRON- PRP cord-342776-hkjhqgie 32 25 mediates mediate VBZ cord-342776-hkjhqgie 32 26 the the DT cord-342776-hkjhqgie 32 27 underlying underlie VBG cord-342776-hkjhqgie 32 28 pathology pathology NN cord-342776-hkjhqgie 32 29 in in IN cord-342776-hkjhqgie 32 30 humans human NNS cord-342776-hkjhqgie 32 31 . . . cord-342776-hkjhqgie 33 1 The the DT cord-342776-hkjhqgie 33 2 problem problem NN cord-342776-hkjhqgie 33 3 has have VBZ cord-342776-hkjhqgie 33 4 been be VBN cord-342776-hkjhqgie 33 5 compounded compound VBN cord-342776-hkjhqgie 33 6 by by IN cord-342776-hkjhqgie 33 7 the the DT cord-342776-hkjhqgie 33 8 limited limited JJ cord-342776-hkjhqgie 33 9 ability ability NN cord-342776-hkjhqgie 33 10 of of IN cord-342776-hkjhqgie 33 11 the the DT cord-342776-hkjhqgie 33 12 research research NN cord-342776-hkjhqgie 33 13 laboratories laboratory NNS cord-342776-hkjhqgie 33 14 to to TO cord-342776-hkjhqgie 33 15 conduct conduct VB cord-342776-hkjhqgie 33 16 studies study NNS cord-342776-hkjhqgie 33 17 due due IN cord-342776-hkjhqgie 33 18 to to IN cord-342776-hkjhqgie 33 19 the the DT cord-342776-hkjhqgie 33 20 implementation implementation NN cord-342776-hkjhqgie 33 21 of of IN cord-342776-hkjhqgie 33 22 social social JJ cord-342776-hkjhqgie 33 23 distancing distancing NN cord-342776-hkjhqgie 33 24 since since IN cord-342776-hkjhqgie 33 25 many many JJ cord-342776-hkjhqgie 33 26 academic academic JJ cord-342776-hkjhqgie 33 27 university university NN cord-342776-hkjhqgie 33 28 laboratories laboratory NNS cord-342776-hkjhqgie 33 29 have have VBP cord-342776-hkjhqgie 33 30 either either CC cord-342776-hkjhqgie 33 31 been be VBN cord-342776-hkjhqgie 33 32 shut shut VBN cord-342776-hkjhqgie 33 33 down down RP cord-342776-hkjhqgie 33 34 or or CC cord-342776-hkjhqgie 33 35 been be VBN cord-342776-hkjhqgie 33 36 operating operate VBG cord-342776-hkjhqgie 33 37 at at IN cord-342776-hkjhqgie 33 38 a a DT cord-342776-hkjhqgie 33 39 minimum minimum JJ cord-342776-hkjhqgie 33 40 capacity capacity NN cord-342776-hkjhqgie 33 41 . . . cord-342776-hkjhqgie 34 1 Although although IN cord-342776-hkjhqgie 34 2 the the DT cord-342776-hkjhqgie 34 3 existing exist VBG cord-342776-hkjhqgie 34 4 novel novel JJ cord-342776-hkjhqgie 34 5 therapeutic therapeutic JJ cord-342776-hkjhqgie 34 6 strategies strategy NNS cord-342776-hkjhqgie 34 7 and and CC cord-342776-hkjhqgie 34 8 research research NN cord-342776-hkjhqgie 34 9 on on IN cord-342776-hkjhqgie 34 10 potential potential JJ cord-342776-hkjhqgie 34 11 vaccines vaccine NNS cord-342776-hkjhqgie 34 12 are be VBP cord-342776-hkjhqgie 34 13 important important JJ cord-342776-hkjhqgie 34 14 directions direction NNS cord-342776-hkjhqgie 34 15 , , , cord-342776-hkjhqgie 34 16 they -PRON- PRP cord-342776-hkjhqgie 34 17 will will MD cord-342776-hkjhqgie 34 18 not not RB cord-342776-hkjhqgie 34 19 be be VB cord-342776-hkjhqgie 34 20 sufficient sufficient JJ cord-342776-hkjhqgie 34 21 to to TO cord-342776-hkjhqgie 34 22 provide provide VB cord-342776-hkjhqgie 34 23 adequate adequate JJ cord-342776-hkjhqgie 34 24 progress progress NN cord-342776-hkjhqgie 34 25 to to TO cord-342776-hkjhqgie 34 26 fully fully RB cord-342776-hkjhqgie 34 27 understand understand VB cord-342776-hkjhqgie 34 28 the the DT cord-342776-hkjhqgie 34 29 potential potential NN cord-342776-hkjhqgie 34 30 of of IN cord-342776-hkjhqgie 34 31 the the DT cord-342776-hkjhqgie 34 32 virus virus NN cord-342776-hkjhqgie 34 33 to to TO cord-342776-hkjhqgie 34 34 infect infect VB cord-342776-hkjhqgie 34 35 individuals individual NNS cord-342776-hkjhqgie 34 36 and and CC cord-342776-hkjhqgie 34 37 the the DT cord-342776-hkjhqgie 34 38 underlying underlie VBG cord-342776-hkjhqgie 34 39 mechanisms mechanism NNS cord-342776-hkjhqgie 34 40 by by IN cord-342776-hkjhqgie 34 41 which which WDT cord-342776-hkjhqgie 34 42 the the DT cord-342776-hkjhqgie 34 43 virus virus NN cord-342776-hkjhqgie 34 44 causes cause VBZ cord-342776-hkjhqgie 34 45 pathology pathology NN cord-342776-hkjhqgie 34 46 . . . cord-342776-hkjhqgie 35 1 Containment containment NN cord-342776-hkjhqgie 35 2 efforts effort NNS cord-342776-hkjhqgie 35 3 , , , cord-342776-hkjhqgie 35 4 through through IN cord-342776-hkjhqgie 35 5 quarantines quarantine NNS cord-342776-hkjhqgie 35 6 and and CC cord-342776-hkjhqgie 35 7 social social JJ cord-342776-hkjhqgie 35 8 distancing distancing NN cord-342776-hkjhqgie 35 9 , , , cord-342776-hkjhqgie 35 10 hand hand NN cord-342776-hkjhqgie 35 11 washing washing NN cord-342776-hkjhqgie 35 12 and and CC cord-342776-hkjhqgie 35 13 wearing wear VBG cord-342776-hkjhqgie 35 14 mask mask NN cord-342776-hkjhqgie 35 15 are be VBP cord-342776-hkjhqgie 35 16 important important JJ cord-342776-hkjhqgie 35 17 directions direction NNS cord-342776-hkjhqgie 35 18 to to TO cord-342776-hkjhqgie 35 19 mitigate mitigate VB cord-342776-hkjhqgie 35 20 the the DT cord-342776-hkjhqgie 35 21 spread spread NN cord-342776-hkjhqgie 35 22 of of IN cord-342776-hkjhqgie 35 23 SARS SARS NNP cord-342776-hkjhqgie 35 24 - - HYPH cord-342776-hkjhqgie 35 25 CoV-2 CoV-2 NNP cord-342776-hkjhqgie 35 26 infections infection NNS cord-342776-hkjhqgie 35 27 . . . cord-342776-hkjhqgie 36 1 However however RB cord-342776-hkjhqgie 36 2 , , , cord-342776-hkjhqgie 36 3 at at IN cord-342776-hkjhqgie 36 4 the the DT cord-342776-hkjhqgie 36 5 moment moment NN cord-342776-hkjhqgie 36 6 , , , cord-342776-hkjhqgie 36 7 we -PRON- PRP cord-342776-hkjhqgie 36 8 do do VBP cord-342776-hkjhqgie 36 9 not not RB cord-342776-hkjhqgie 36 10 have have VB cord-342776-hkjhqgie 36 11 the the DT cord-342776-hkjhqgie 36 12 capability capability NN cord-342776-hkjhqgie 36 13 of of IN cord-342776-hkjhqgie 36 14 large large JJ cord-342776-hkjhqgie 36 15 scale scale NN cord-342776-hkjhqgie 36 16 testing testing NN cord-342776-hkjhqgie 36 17 which which WDT cord-342776-hkjhqgie 36 18 would would MD cord-342776-hkjhqgie 36 19 be be VB cord-342776-hkjhqgie 36 20 necessary necessary JJ cord-342776-hkjhqgie 36 21 for for IN cord-342776-hkjhqgie 36 22 the the DT cord-342776-hkjhqgie 36 23 identification identification NN cord-342776-hkjhqgie 36 24 and and CC cord-342776-hkjhqgie 36 25 isolation isolation NN cord-342776-hkjhqgie 36 26 of of IN cord-342776-hkjhqgie 36 27 asymptomatic asymptomatic JJ cord-342776-hkjhqgie 36 28 and and CC cord-342776-hkjhqgie 36 29 symptomatic symptomatic JJ cord-342776-hkjhqgie 36 30 patients patient NNS cord-342776-hkjhqgie 36 31 to to TO cord-342776-hkjhqgie 36 32 halt halt VB cord-342776-hkjhqgie 36 33 the the DT cord-342776-hkjhqgie 36 34 chain chain NN cord-342776-hkjhqgie 36 35 of of IN cord-342776-hkjhqgie 36 36 viral viral JJ cord-342776-hkjhqgie 36 37 transmission transmission NN cord-342776-hkjhqgie 36 38 . . . cord-342776-hkjhqgie 37 1 Therefore therefore RB cord-342776-hkjhqgie 37 2 , , , cord-342776-hkjhqgie 37 3 until until IN cord-342776-hkjhqgie 37 4 the the DT cord-342776-hkjhqgie 37 5 existing exist VBG cord-342776-hkjhqgie 37 6 public public JJ cord-342776-hkjhqgie 37 7 health health NN cord-342776-hkjhqgie 37 8 measures measure NNS cord-342776-hkjhqgie 37 9 are be VBP cord-342776-hkjhqgie 37 10 able able JJ cord-342776-hkjhqgie 37 11 to to TO cord-342776-hkjhqgie 37 12 curtail curtail VB cord-342776-hkjhqgie 37 13 the the DT cord-342776-hkjhqgie 37 14 transmission transmission NN cord-342776-hkjhqgie 37 15 and and CC cord-342776-hkjhqgie 37 16 bring bring VB cord-342776-hkjhqgie 37 17 the the DT cord-342776-hkjhqgie 37 18 disease disease NN cord-342776-hkjhqgie 37 19 somewhat somewhat RB cord-342776-hkjhqgie 37 20 under under IN cord-342776-hkjhqgie 37 21 control control NN cord-342776-hkjhqgie 37 22 , , , cord-342776-hkjhqgie 37 23 the the DT cord-342776-hkjhqgie 37 24 research research NN cord-342776-hkjhqgie 37 25 laboratories laboratory NNS cord-342776-hkjhqgie 37 26 will will MD cord-342776-hkjhqgie 37 27 not not RB cord-342776-hkjhqgie 37 28 be be VB cord-342776-hkjhqgie 37 29 able able JJ cord-342776-hkjhqgie 37 30 to to TO cord-342776-hkjhqgie 37 31 fully fully RB cord-342776-hkjhqgie 37 32 engage engage VB cord-342776-hkjhqgie 37 33 in in IN cord-342776-hkjhqgie 37 34 the the DT cord-342776-hkjhqgie 37 35 studies study NNS cord-342776-hkjhqgie 37 36 of of IN cord-342776-hkjhqgie 37 37 COVID-19 COVID-19 NNP cord-342776-hkjhqgie 37 38 disease disease NN cord-342776-hkjhqgie 37 39 worldwide worldwide RB cord-342776-hkjhqgie 37 40 , , , cord-342776-hkjhqgie 37 41 thereby thereby RB cord-342776-hkjhqgie 37 42 slowing slow VBG cord-342776-hkjhqgie 37 43 the the DT cord-342776-hkjhqgie 37 44 discoveries discovery NNS cord-342776-hkjhqgie 37 45 of of IN cord-342776-hkjhqgie 37 46 more more JJR cord-342776-hkjhqgie 37 47 effective effective JJ cord-342776-hkjhqgie 37 48 treatments treatment NNS cord-342776-hkjhqgie 37 49 and and CC cord-342776-hkjhqgie 37 50 vaccines vaccine NNS cord-342776-hkjhqgie 37 51 . . . cord-342776-hkjhqgie 38 1 Progression progression NN cord-342776-hkjhqgie 38 2 models model NNS cord-342776-hkjhqgie 38 3 of of IN cord-342776-hkjhqgie 38 4 COVID-19 COVID-19 NNP cord-342776-hkjhqgie 38 5 disease disease NN cord-342776-hkjhqgie 38 6 paint paint VBP cord-342776-hkjhqgie 38 7 a a DT cord-342776-hkjhqgie 38 8 dismal dismal JJ cord-342776-hkjhqgie 38 9 forecast forecast NN cord-342776-hkjhqgie 38 10 for for IN cord-342776-hkjhqgie 38 11 the the DT cord-342776-hkjhqgie 38 12 duration duration NN cord-342776-hkjhqgie 38 13 of of IN cord-342776-hkjhqgie 38 14 the the DT cord-342776-hkjhqgie 38 15 outbreak outbreak NN cord-342776-hkjhqgie 38 16 , , , cord-342776-hkjhqgie 38 17 and and CC cord-342776-hkjhqgie 38 18 therefore therefore RB cord-342776-hkjhqgie 38 19 , , , cord-342776-hkjhqgie 38 20 warrant warrant VB cord-342776-hkjhqgie 38 21 the the DT cord-342776-hkjhqgie 38 22 discovery discovery NN cord-342776-hkjhqgie 38 23 of of IN cord-342776-hkjhqgie 38 24 novel novel JJ cord-342776-hkjhqgie 38 25 treatments treatment NNS cord-342776-hkjhqgie 38 26 to to TO cord-342776-hkjhqgie 38 27 alleviate alleviate VB cord-342776-hkjhqgie 38 28 disease disease NN cord-342776-hkjhqgie 38 29 symptoms symptom NNS cord-342776-hkjhqgie 38 30 that that WDT cord-342776-hkjhqgie 38 31 will will MD cord-342776-hkjhqgie 38 32 supplement supplement VB cord-342776-hkjhqgie 38 33 containment containment NN cord-342776-hkjhqgie 38 34 efforts effort NNS cord-342776-hkjhqgie 38 35 . . . cord-342776-hkjhqgie 39 1 Researchers researcher NNS cord-342776-hkjhqgie 39 2 continue continue VBP cord-342776-hkjhqgie 39 3 to to TO cord-342776-hkjhqgie 39 4 search search VB cord-342776-hkjhqgie 39 5 for for IN cord-342776-hkjhqgie 39 6 viable viable JJ cord-342776-hkjhqgie 39 7 treatments treatment NNS cord-342776-hkjhqgie 39 8 to to TO cord-342776-hkjhqgie 39 9 alleviate alleviate VB cord-342776-hkjhqgie 39 10 symptoms symptom NNS cord-342776-hkjhqgie 39 11 of of IN cord-342776-hkjhqgie 39 12 the the DT cord-342776-hkjhqgie 39 13 disease disease NN cord-342776-hkjhqgie 39 14 and and CC cord-342776-hkjhqgie 39 15 to to TO cord-342776-hkjhqgie 39 16 eradicate eradicate VB cord-342776-hkjhqgie 39 17 the the DT cord-342776-hkjhqgie 39 18 spread spread NN cord-342776-hkjhqgie 39 19 of of IN cord-342776-hkjhqgie 39 20 the the DT cord-342776-hkjhqgie 39 21 disease disease NN cord-342776-hkjhqgie 39 22 . . . cord-342776-hkjhqgie 40 1 The the DT cord-342776-hkjhqgie 40 2 search search NN cord-342776-hkjhqgie 40 3 for for IN cord-342776-hkjhqgie 40 4 effective effective JJ cord-342776-hkjhqgie 40 5 treatments treatment NNS cord-342776-hkjhqgie 40 6 for for IN cord-342776-hkjhqgie 40 7 COVID-19 COVID-19 NNP cord-342776-hkjhqgie 40 8 disease disease NN cord-342776-hkjhqgie 40 9 has have VBZ cord-342776-hkjhqgie 40 10 featured feature VBN cord-342776-hkjhqgie 40 11 studies study NNS cord-342776-hkjhqgie 40 12 advocating advocate VBG cord-342776-hkjhqgie 40 13 for for IN cord-342776-hkjhqgie 40 14 the the DT cord-342776-hkjhqgie 40 15 potential potential JJ cord-342776-hkjhqgie 40 16 use use NN cord-342776-hkjhqgie 40 17 of of IN cord-342776-hkjhqgie 40 18 the the DT cord-342776-hkjhqgie 40 19 anti anti JJ cord-342776-hkjhqgie 40 20 - - JJ cord-342776-hkjhqgie 40 21 malarial malarial JJ cord-342776-hkjhqgie 40 22 drugs drug NNS cord-342776-hkjhqgie 40 23 , , , cord-342776-hkjhqgie 40 24 hydroxychloroquine hydroxychloroquine NN cord-342776-hkjhqgie 40 25 . . . cord-342776-hkjhqgie 41 1 The the DT cord-342776-hkjhqgie 41 2 placebo placebo NN cord-342776-hkjhqgie 41 3 controlled control VBN cord-342776-hkjhqgie 41 4 studies study NNS cord-342776-hkjhqgie 41 5 of of IN cord-342776-hkjhqgie 41 6 hydroxychloroquine hydroxychloroquine NNP cord-342776-hkjhqgie 41 7 have have VBP cord-342776-hkjhqgie 41 8 not not RB cord-342776-hkjhqgie 41 9 shown show VBN cord-342776-hkjhqgie 41 10 any any DT cord-342776-hkjhqgie 41 11 efficacy efficacy NN cord-342776-hkjhqgie 41 12 , , , cord-342776-hkjhqgie 41 13 and and CC cord-342776-hkjhqgie 41 14 indeed indeed RB cord-342776-hkjhqgie 41 15 , , , cord-342776-hkjhqgie 41 16 in in IN cord-342776-hkjhqgie 41 17 certain certain JJ cord-342776-hkjhqgie 41 18 cases case NNS cord-342776-hkjhqgie 41 19 they -PRON- PRP cord-342776-hkjhqgie 41 20 have have VBP cord-342776-hkjhqgie 41 21 exhibited exhibit VBN cord-342776-hkjhqgie 41 22 dangerous dangerous JJ cord-342776-hkjhqgie 41 23 side side NN cord-342776-hkjhqgie 41 24 effects effect NNS cord-342776-hkjhqgie 41 25 in in IN cord-342776-hkjhqgie 41 26 patients patient NNS cord-342776-hkjhqgie 41 27 . . . cord-342776-hkjhqgie 42 1 Others other NNS cord-342776-hkjhqgie 42 2 have have VBP cord-342776-hkjhqgie 42 3 advocated advocate VBN cord-342776-hkjhqgie 42 4 the the DT cord-342776-hkjhqgie 42 5 immunologic immunologic JJ cord-342776-hkjhqgie 42 6 path path NN cord-342776-hkjhqgie 42 7 in in IN cord-342776-hkjhqgie 42 8 support support NN cord-342776-hkjhqgie 42 9 of of IN cord-342776-hkjhqgie 42 10 monoclonal monoclonal JJ cord-342776-hkjhqgie 42 11 antibody antibody NN cord-342776-hkjhqgie 42 12 therapy therapy NN cord-342776-hkjhqgie 42 13 ( ( -LRB- cord-342776-hkjhqgie 42 14 9 9 CD cord-342776-hkjhqgie 42 15 , , , cord-342776-hkjhqgie 42 16 10 10 CD cord-342776-hkjhqgie 42 17 ) ) -RRB- cord-342776-hkjhqgie 42 18 . . . cord-342776-hkjhqgie 43 1 On on IN cord-342776-hkjhqgie 43 2 the the DT cord-342776-hkjhqgie 43 3 other other JJ cord-342776-hkjhqgie 43 4 hand hand NN cord-342776-hkjhqgie 43 5 Remdesivir Remdesivir NNP cord-342776-hkjhqgie 43 6 , , , cord-342776-hkjhqgie 43 7 an an DT cord-342776-hkjhqgie 43 8 antiviral antiviral JJ cord-342776-hkjhqgie 43 9 drug drug NN cord-342776-hkjhqgie 43 10 , , , cord-342776-hkjhqgie 43 11 was be VBD cord-342776-hkjhqgie 43 12 shown show VBN cord-342776-hkjhqgie 43 13 to to TO cord-342776-hkjhqgie 43 14 be be VB cord-342776-hkjhqgie 43 15 superior superior JJ cord-342776-hkjhqgie 43 16 to to IN cord-342776-hkjhqgie 43 17 placebo placebo NN cord-342776-hkjhqgie 43 18 in in IN cord-342776-hkjhqgie 43 19 shortening shorten VBG cord-342776-hkjhqgie 43 20 the the DT cord-342776-hkjhqgie 43 21 time time NN cord-342776-hkjhqgie 43 22 to to IN cord-342776-hkjhqgie 43 23 recovery recovery NN cord-342776-hkjhqgie 43 24 in in IN cord-342776-hkjhqgie 43 25 adults adult NNS cord-342776-hkjhqgie 43 26 hospitalized hospitalize VBN cord-342776-hkjhqgie 43 27 with with IN cord-342776-hkjhqgie 43 28 Covid-19 covid-19 NN cord-342776-hkjhqgie 43 29 disease disease NN cord-342776-hkjhqgie 43 30 with with IN cord-342776-hkjhqgie 43 31 the the DT cord-342776-hkjhqgie 43 32 evidence evidence NN cord-342776-hkjhqgie 43 33 of of IN cord-342776-hkjhqgie 43 34 lower low JJR cord-342776-hkjhqgie 43 35 respiratory respiratory JJ cord-342776-hkjhqgie 43 36 tract tract NN cord-342776-hkjhqgie 43 37 infection infection NN cord-342776-hkjhqgie 43 38 ( ( -LRB- cord-342776-hkjhqgie 43 39 11 11 CD cord-342776-hkjhqgie 43 40 ) ) -RRB- cord-342776-hkjhqgie 43 41 . . . cord-342776-hkjhqgie 44 1 The the DT cord-342776-hkjhqgie 44 2 development development NN cord-342776-hkjhqgie 44 3 of of IN cord-342776-hkjhqgie 44 4 a a DT cord-342776-hkjhqgie 44 5 SARS SARS NNP cord-342776-hkjhqgie 44 6 - - HYPH cord-342776-hkjhqgie 44 7 CoV-2 CoV-2 NNP cord-342776-hkjhqgie 44 8 vaccine vaccine NN cord-342776-hkjhqgie 44 9 would would MD cord-342776-hkjhqgie 44 10 utilize utilize VB cord-342776-hkjhqgie 44 11 the the DT cord-342776-hkjhqgie 44 12 adaptive adaptive JJ cord-342776-hkjhqgie 44 13 immune immune JJ cord-342776-hkjhqgie 44 14 system system NN cord-342776-hkjhqgie 44 15 to to TO cord-342776-hkjhqgie 44 16 combat combat VB cord-342776-hkjhqgie 44 17 symptoms symptom NNS cord-342776-hkjhqgie 44 18 in in IN cord-342776-hkjhqgie 44 19 patients patient NNS cord-342776-hkjhqgie 44 20 , , , cord-342776-hkjhqgie 44 21 along along IN cord-342776-hkjhqgie 44 22 with with IN cord-342776-hkjhqgie 44 23 providing provide VBG cord-342776-hkjhqgie 44 24 a a DT cord-342776-hkjhqgie 44 25 preventative preventative JJ cord-342776-hkjhqgie 44 26 measure measure NN cord-342776-hkjhqgie 44 27 for for IN cord-342776-hkjhqgie 44 28 healthy healthy JJ cord-342776-hkjhqgie 44 29 individuals individual NNS cord-342776-hkjhqgie 44 30 . . . cord-342776-hkjhqgie 45 1 However however RB cord-342776-hkjhqgie 45 2 , , , cord-342776-hkjhqgie 45 3 current current JJ cord-342776-hkjhqgie 45 4 timelines timeline NNS cord-342776-hkjhqgie 45 5 estimate estimate VBP cord-342776-hkjhqgie 45 6 that that IN cord-342776-hkjhqgie 45 7 vaccine vaccine NN cord-342776-hkjhqgie 45 8 development development NN cord-342776-hkjhqgie 45 9 could could MD cord-342776-hkjhqgie 45 10 take take VB cord-342776-hkjhqgie 45 11 up up RP cord-342776-hkjhqgie 45 12 to to IN cord-342776-hkjhqgie 45 13 anywhere anywhere RB cord-342776-hkjhqgie 45 14 from from IN cord-342776-hkjhqgie 45 15 12 12 CD cord-342776-hkjhqgie 45 16 to to TO cord-342776-hkjhqgie 45 17 18 18 CD cord-342776-hkjhqgie 45 18 months month NNS cord-342776-hkjhqgie 45 19 . . . cord-342776-hkjhqgie 46 1 While while IN cord-342776-hkjhqgie 46 2 studies study NNS cord-342776-hkjhqgie 46 3 on on IN cord-342776-hkjhqgie 46 4 SARS SARS NNP cord-342776-hkjhqgie 46 5 - - HYPH cord-342776-hkjhqgie 46 6 CoV-2 CoV-2 NNP cord-342776-hkjhqgie 46 7 's 's POS cord-342776-hkjhqgie 46 8 effects effect NNS cord-342776-hkjhqgie 46 9 on on IN cord-342776-hkjhqgie 46 10 immune immune JJ cord-342776-hkjhqgie 46 11 functions function NNS cord-342776-hkjhqgie 46 12 continue continue VBP cord-342776-hkjhqgie 46 13 to to TO cord-342776-hkjhqgie 46 14 progress progress VB cord-342776-hkjhqgie 46 15 , , , cord-342776-hkjhqgie 46 16 published publish VBN cord-342776-hkjhqgie 46 17 studies study NNS cord-342776-hkjhqgie 46 18 concerning concern VBG cord-342776-hkjhqgie 46 19 other other JJ cord-342776-hkjhqgie 46 20 coronaviruses coronaviruse NNS cord-342776-hkjhqgie 46 21 may may MD cord-342776-hkjhqgie 46 22 shed shed VB cord-342776-hkjhqgie 46 23 some some DT cord-342776-hkjhqgie 46 24 light light NN cord-342776-hkjhqgie 46 25 on on IN cord-342776-hkjhqgie 46 26 how how WRB cord-342776-hkjhqgie 46 27 the the DT cord-342776-hkjhqgie 46 28 immune immune JJ cord-342776-hkjhqgie 46 29 system system NN cord-342776-hkjhqgie 46 30 may may MD cord-342776-hkjhqgie 46 31 be be VB cord-342776-hkjhqgie 46 32 employed employ VBN cord-342776-hkjhqgie 46 33 to to TO cord-342776-hkjhqgie 46 34 mitigate mitigate VB cord-342776-hkjhqgie 46 35 COVID-19 COVID-19 NNP cord-342776-hkjhqgie 46 36 disease disease NN cord-342776-hkjhqgie 46 37 . . . cord-342776-hkjhqgie 47 1 Based base VBN cord-342776-hkjhqgie 47 2 on on IN cord-342776-hkjhqgie 47 3 experiences experience NNS cord-342776-hkjhqgie 47 4 with with IN cord-342776-hkjhqgie 47 5 coronaviruses coronaviruse NNS cord-342776-hkjhqgie 47 6 in in IN cord-342776-hkjhqgie 47 7 SARS SARS NNP cord-342776-hkjhqgie 47 8 and and CC cord-342776-hkjhqgie 47 9 MERS MERS NNP cord-342776-hkjhqgie 47 10 , , , cord-342776-hkjhqgie 47 11 it -PRON- PRP cord-342776-hkjhqgie 47 12 has have VBZ cord-342776-hkjhqgie 47 13 been be VBN cord-342776-hkjhqgie 47 14 suggested suggest VBN cord-342776-hkjhqgie 47 15 that that IN cord-342776-hkjhqgie 47 16 the the DT cord-342776-hkjhqgie 47 17 SARS SARS NNP cord-342776-hkjhqgie 47 18 - - HYPH cord-342776-hkjhqgie 47 19 CoV-2 CoV-2 NNP cord-342776-hkjhqgie 47 20 infection infection NN cord-342776-hkjhqgie 47 21 may may MD cord-342776-hkjhqgie 47 22 also also RB cord-342776-hkjhqgie 47 23 trigger trigger VB cord-342776-hkjhqgie 47 24 major major JJ cord-342776-hkjhqgie 47 25 immunological immunological JJ cord-342776-hkjhqgie 47 26 changes change NNS cord-342776-hkjhqgie 47 27 , , , cord-342776-hkjhqgie 47 28 such such JJ cord-342776-hkjhqgie 47 29 as as IN cord-342776-hkjhqgie 47 30 delayed delay VBN cord-342776-hkjhqgie 47 31 or or CC cord-342776-hkjhqgie 47 32 suppressed suppress VBN cord-342776-hkjhqgie 47 33 Type type NN cord-342776-hkjhqgie 47 34 1 1 CD cord-342776-hkjhqgie 47 35 IFN IFN NNP cord-342776-hkjhqgie 47 36 response response NN cord-342776-hkjhqgie 47 37 and and CC cord-342776-hkjhqgie 47 38 the the DT cord-342776-hkjhqgie 47 39 influx influx NN cord-342776-hkjhqgie 47 40 of of IN cord-342776-hkjhqgie 47 41 activated activate VBN cord-342776-hkjhqgie 47 42 neutrophils neutrophil NNS cord-342776-hkjhqgie 47 43 and and CC cord-342776-hkjhqgie 47 44 inflammatory inflammatory JJ cord-342776-hkjhqgie 47 45 monocytes monocyte NNS cord-342776-hkjhqgie 47 46 / / SYM cord-342776-hkjhqgie 47 47 macrophages macrophage NNS cord-342776-hkjhqgie 47 48 ( ( -LRB- cord-342776-hkjhqgie 47 49 12 12 CD cord-342776-hkjhqgie 47 50 ) ) -RRB- cord-342776-hkjhqgie 47 51 . . . cord-342776-hkjhqgie 48 1 In in IN cord-342776-hkjhqgie 48 2 addition addition NN cord-342776-hkjhqgie 48 3 , , , cord-342776-hkjhqgie 48 4 the the DT cord-342776-hkjhqgie 48 5 effect effect NN cord-342776-hkjhqgie 48 6 of of IN cord-342776-hkjhqgie 48 7 virus virus NN cord-342776-hkjhqgie 48 8 on on IN cord-342776-hkjhqgie 48 9 host host NN cord-342776-hkjhqgie 48 10 following follow VBG cord-342776-hkjhqgie 48 11 infection infection NN cord-342776-hkjhqgie 48 12 has have VBZ cord-342776-hkjhqgie 48 13 demonstrated demonstrate VBN cord-342776-hkjhqgie 48 14 severe severe JJ cord-342776-hkjhqgie 48 15 changes change NNS cord-342776-hkjhqgie 48 16 in in IN cord-342776-hkjhqgie 48 17 the the DT cord-342776-hkjhqgie 48 18 proportion proportion NN cord-342776-hkjhqgie 48 19 of of IN cord-342776-hkjhqgie 48 20 different different JJ cord-342776-hkjhqgie 48 21 immune immune JJ cord-342776-hkjhqgie 48 22 effectors effector NNS cord-342776-hkjhqgie 48 23 ( ( -LRB- cord-342776-hkjhqgie 48 24 13 13 CD cord-342776-hkjhqgie 48 25 ) ) -RRB- cord-342776-hkjhqgie 48 26 . . . cord-342776-hkjhqgie 49 1 In in IN cord-342776-hkjhqgie 49 2 particular particular JJ cord-342776-hkjhqgie 49 3 , , , cord-342776-hkjhqgie 49 4 in in IN cord-342776-hkjhqgie 49 5 the the DT cord-342776-hkjhqgie 49 6 peripheral peripheral JJ cord-342776-hkjhqgie 49 7 blood blood NN cord-342776-hkjhqgie 49 8 of of IN cord-342776-hkjhqgie 49 9 patients patient NNS cord-342776-hkjhqgie 49 10 that that WDT cord-342776-hkjhqgie 49 11 were be VBD cord-342776-hkjhqgie 49 12 infected infect VBN cord-342776-hkjhqgie 49 13 with with IN cord-342776-hkjhqgie 49 14 SARS SARS NNP cord-342776-hkjhqgie 49 15 , , , cord-342776-hkjhqgie 49 16 it -PRON- PRP cord-342776-hkjhqgie 49 17 was be VBD cord-342776-hkjhqgie 49 18 noted note VBN cord-342776-hkjhqgie 49 19 that that IN cord-342776-hkjhqgie 49 20 there there EX cord-342776-hkjhqgie 49 21 were be VBD cord-342776-hkjhqgie 49 22 significantly significantly RB cord-342776-hkjhqgie 49 23 lower low JJR cord-342776-hkjhqgie 49 24 numbers number NNS cord-342776-hkjhqgie 49 25 of of IN cord-342776-hkjhqgie 49 26 natural natural JJ cord-342776-hkjhqgie 49 27 killer killer NN cord-342776-hkjhqgie 49 28 ( ( -LRB- cord-342776-hkjhqgie 49 29 NK NK NNP cord-342776-hkjhqgie 49 30 ) ) -RRB- cord-342776-hkjhqgie 49 31 cells cell NNS cord-342776-hkjhqgie 49 32 compared compare VBN cord-342776-hkjhqgie 49 33 to to IN cord-342776-hkjhqgie 49 34 healthy healthy JJ cord-342776-hkjhqgie 49 35 subjects subject NNS cord-342776-hkjhqgie 49 36 ( ( -LRB- cord-342776-hkjhqgie 49 37 14 14 CD cord-342776-hkjhqgie 49 38 ) ) -RRB- cord-342776-hkjhqgie 49 39 . . . cord-342776-hkjhqgie 50 1 Such such JJ cord-342776-hkjhqgie 50 2 a a DT cord-342776-hkjhqgie 50 3 profile profile NN cord-342776-hkjhqgie 50 4 has have VBZ cord-342776-hkjhqgie 50 5 also also RB cord-342776-hkjhqgie 50 6 been be VBN cord-342776-hkjhqgie 50 7 extended extend VBN cord-342776-hkjhqgie 50 8 to to IN cord-342776-hkjhqgie 50 9 the the DT cord-342776-hkjhqgie 50 10 immune immune JJ cord-342776-hkjhqgie 50 11 responses response NNS cord-342776-hkjhqgie 50 12 of of IN cord-342776-hkjhqgie 50 13 COVID-19 covid-19 JJ cord-342776-hkjhqgie 50 14 individuals individual NNS cord-342776-hkjhqgie 50 15 . . . cord-342776-hkjhqgie 51 1 A a DT cord-342776-hkjhqgie 51 2 study study NN cord-342776-hkjhqgie 51 3 of of IN cord-342776-hkjhqgie 51 4 452 452 CD cord-342776-hkjhqgie 51 5 COVID-19 COVID-19 NNP cord-342776-hkjhqgie 51 6 individuals individual NNS cord-342776-hkjhqgie 51 7 demonstrated demonstrate VBD cord-342776-hkjhqgie 51 8 that that IN cord-342776-hkjhqgie 51 9 the the DT cord-342776-hkjhqgie 51 10 numbers number NNS cord-342776-hkjhqgie 51 11 of of IN cord-342776-hkjhqgie 51 12 NK NK NNP cord-342776-hkjhqgie 51 13 , , , cord-342776-hkjhqgie 51 14 B B NNP cord-342776-hkjhqgie 51 15 and and CC cord-342776-hkjhqgie 51 16 T t NN cord-342776-hkjhqgie 51 17 cells cell NNS cord-342776-hkjhqgie 51 18 were be VBD cord-342776-hkjhqgie 51 19 significantly significantly RB cord-342776-hkjhqgie 51 20 decreased decrease VBN cord-342776-hkjhqgie 51 21 , , , cord-342776-hkjhqgie 51 22 with with IN cord-342776-hkjhqgie 51 23 more more JJR cord-342776-hkjhqgie 51 24 severe severe JJ cord-342776-hkjhqgie 51 25 cases case NNS cord-342776-hkjhqgie 51 26 being be VBG cord-342776-hkjhqgie 51 27 associated associate VBN cord-342776-hkjhqgie 51 28 with with IN cord-342776-hkjhqgie 51 29 greater great JJR cord-342776-hkjhqgie 51 30 decreases decrease NNS cord-342776-hkjhqgie 51 31 in in IN cord-342776-hkjhqgie 51 32 the the DT cord-342776-hkjhqgie 51 33 numbers number NNS cord-342776-hkjhqgie 51 34 ( ( -LRB- cord-342776-hkjhqgie 51 35 15 15 CD cord-342776-hkjhqgie 51 36 ) ) -RRB- cord-342776-hkjhqgie 51 37 , , , cord-342776-hkjhqgie 51 38 Please please UH cord-342776-hkjhqgie 51 39 see see VB cord-342776-hkjhqgie 51 40 the the DT cord-342776-hkjhqgie 51 41 references reference NNS cord-342776-hkjhqgie 51 42 ( ( -LRB- cord-342776-hkjhqgie 51 43 16 16 CD cord-342776-hkjhqgie 51 44 ) ) -RRB- cord-342776-hkjhqgie 51 45 ( ( -LRB- cord-342776-hkjhqgie 51 46 17 17 CD cord-342776-hkjhqgie 51 47 ) ) -RRB- cord-342776-hkjhqgie 51 48 ( ( -LRB- cord-342776-hkjhqgie 51 49 18 18 CD cord-342776-hkjhqgie 51 50 ) ) -RRB- cord-342776-hkjhqgie 51 51 ( ( -LRB- cord-342776-hkjhqgie 51 52 19 19 CD cord-342776-hkjhqgie 51 53 ) ) -RRB- cord-342776-hkjhqgie 51 54 for for IN cord-342776-hkjhqgie 51 55 reviews review NNS cord-342776-hkjhqgie 51 56 on on IN cord-342776-hkjhqgie 51 57 the the DT cord-342776-hkjhqgie 51 58 potential potential JJ cord-342776-hkjhqgie 51 59 mechanisms mechanism NNS cord-342776-hkjhqgie 51 60 of of IN cord-342776-hkjhqgie 51 61 inactivation inactivation NN cord-342776-hkjhqgie 51 62 and and CC cord-342776-hkjhqgie 51 63 loss loss NN cord-342776-hkjhqgie 51 64 of of IN cord-342776-hkjhqgie 51 65 NK NK NNP cord-342776-hkjhqgie 51 66 cells cell NNS cord-342776-hkjhqgie 51 67 . . . cord-342776-hkjhqgie 52 1 Upon upon IN cord-342776-hkjhqgie 52 2 admission admission NN cord-342776-hkjhqgie 52 3 , , , cord-342776-hkjhqgie 52 4 the the DT cord-342776-hkjhqgie 52 5 neutrophil neutrophil NN cord-342776-hkjhqgie 52 6 counts count NNS cord-342776-hkjhqgie 52 7 were be VBD cord-342776-hkjhqgie 52 8 remarkably remarkably RB cord-342776-hkjhqgie 52 9 higher high JJR cord-342776-hkjhqgie 52 10 in in IN cord-342776-hkjhqgie 52 11 patients patient NNS cord-342776-hkjhqgie 52 12 with with IN cord-342776-hkjhqgie 52 13 severe severe JJ cord-342776-hkjhqgie 52 14 COVID-19 covid-19 JJ cord-342776-hkjhqgie 52 15 disease disease NN cord-342776-hkjhqgie 52 16 than than IN cord-342776-hkjhqgie 52 17 in in IN cord-342776-hkjhqgie 52 18 the the DT cord-342776-hkjhqgie 52 19 mild mild JJ cord-342776-hkjhqgie 52 20 cases case NNS cord-342776-hkjhqgie 52 21 , , , cord-342776-hkjhqgie 52 22 whereas whereas IN cord-342776-hkjhqgie 52 23 the the DT cord-342776-hkjhqgie 52 24 total total JJ cord-342776-hkjhqgie 52 25 lymphocyte lymphocyte NN cord-342776-hkjhqgie 52 26 counts count NNS cord-342776-hkjhqgie 52 27 were be VBD cord-342776-hkjhqgie 52 28 significantly significantly RB cord-342776-hkjhqgie 52 29 lower low JJR cord-342776-hkjhqgie 52 30 in in IN cord-342776-hkjhqgie 52 31 severe severe JJ cord-342776-hkjhqgie 52 32 cases case NNS cord-342776-hkjhqgie 52 33 when when WRB cord-342776-hkjhqgie 52 34 compared compare VBN cord-342776-hkjhqgie 52 35 to to IN cord-342776-hkjhqgie 52 36 the the DT cord-342776-hkjhqgie 52 37 mild mild JJ cord-342776-hkjhqgie 52 38 cases case NNS cord-342776-hkjhqgie 52 39 ( ( -LRB- cord-342776-hkjhqgie 52 40 15 15 CD cord-342776-hkjhqgie 52 41 ) ) -RRB- cord-342776-hkjhqgie 52 42 . . . cord-342776-hkjhqgie 53 1 The the DT cord-342776-hkjhqgie 53 2 numbers number NNS cord-342776-hkjhqgie 53 3 of of IN cord-342776-hkjhqgie 53 4 NK NK NNP cord-342776-hkjhqgie 53 5 cells cell NNS cord-342776-hkjhqgie 53 6 and and CC cord-342776-hkjhqgie 53 7 total total JJ cord-342776-hkjhqgie 53 8 T t NN cord-342776-hkjhqgie 53 9 cells cell NNS cord-342776-hkjhqgie 53 10 as as RB cord-342776-hkjhqgie 53 11 well well RB cord-342776-hkjhqgie 53 12 as as IN cord-342776-hkjhqgie 53 13 CD8 CD8 NNP cord-342776-hkjhqgie 53 14 + + CC cord-342776-hkjhqgie 53 15 T T NNP cord-342776-hkjhqgie 53 16 cells cell NNS cord-342776-hkjhqgie 53 17 were be VBD cord-342776-hkjhqgie 53 18 significantly significantly RB cord-342776-hkjhqgie 53 19 lower low JJR cord-342776-hkjhqgie 53 20 in in IN cord-342776-hkjhqgie 53 21 patients patient NNS cord-342776-hkjhqgie 53 22 exhibiting exhibit VBG cord-342776-hkjhqgie 53 23 severe severe JJ cord-342776-hkjhqgie 53 24 symptoms symptom NNS cord-342776-hkjhqgie 53 25 when when WRB cord-342776-hkjhqgie 53 26 compared compare VBN cord-342776-hkjhqgie 53 27 to to IN cord-342776-hkjhqgie 53 28 those those DT cord-342776-hkjhqgie 53 29 with with IN cord-342776-hkjhqgie 53 30 the the DT cord-342776-hkjhqgie 53 31 mild mild JJ cord-342776-hkjhqgie 53 32 symptoms symptom NNS cord-342776-hkjhqgie 53 33 and and CC cord-342776-hkjhqgie 53 34 healthy healthy JJ cord-342776-hkjhqgie 53 35 controls control NNS cord-342776-hkjhqgie 53 36 ( ( -LRB- cord-342776-hkjhqgie 53 37 20 20 CD cord-342776-hkjhqgie 53 38 ) ) -RRB- cord-342776-hkjhqgie 53 39 . . . cord-342776-hkjhqgie 54 1 Thus thus RB cord-342776-hkjhqgie 54 2 , , , cord-342776-hkjhqgie 54 3 a a DT cord-342776-hkjhqgie 54 4 correlation correlation NN cord-342776-hkjhqgie 54 5 could could MD cord-342776-hkjhqgie 54 6 be be VB cord-342776-hkjhqgie 54 7 seen see VBN cord-342776-hkjhqgie 54 8 with with IN cord-342776-hkjhqgie 54 9 severe severe JJ cord-342776-hkjhqgie 54 10 decrease decrease NN cord-342776-hkjhqgie 54 11 in in IN cord-342776-hkjhqgie 54 12 NK NK NNP cord-342776-hkjhqgie 54 13 and and CC cord-342776-hkjhqgie 54 14 T T NNP cord-342776-hkjhqgie 54 15 cell cell NN cord-342776-hkjhqgie 54 16 numbers number NNS cord-342776-hkjhqgie 54 17 and and CC cord-342776-hkjhqgie 54 18 the the DT cord-342776-hkjhqgie 54 19 extent extent NN cord-342776-hkjhqgie 54 20 of of IN cord-342776-hkjhqgie 54 21 severity severity NN cord-342776-hkjhqgie 54 22 of of IN cord-342776-hkjhqgie 54 23 the the DT cord-342776-hkjhqgie 54 24 disease disease NN cord-342776-hkjhqgie 54 25 . . . cord-342776-hkjhqgie 55 1 Furthermore furthermore RB cord-342776-hkjhqgie 55 2 , , , cord-342776-hkjhqgie 55 3 the the DT cord-342776-hkjhqgie 55 4 function function NN cord-342776-hkjhqgie 55 5 of of IN cord-342776-hkjhqgie 55 6 NK NK NNP cord-342776-hkjhqgie 55 7 and and CC cord-342776-hkjhqgie 55 8 CD8 CD8 NNP cord-342776-hkjhqgie 55 9 + + CC cord-342776-hkjhqgie 55 10 T T NNP cord-342776-hkjhqgie 55 11 cells cell NNS cord-342776-hkjhqgie 55 12 was be VBD cord-342776-hkjhqgie 55 13 found find VBN cord-342776-hkjhqgie 55 14 to to TO cord-342776-hkjhqgie 55 15 be be VB cord-342776-hkjhqgie 55 16 suppressed suppress VBN cord-342776-hkjhqgie 55 17 along along RP cord-342776-hkjhqgie 55 18 with with IN cord-342776-hkjhqgie 55 19 the the DT cord-342776-hkjhqgie 55 20 increased increase VBN cord-342776-hkjhqgie 55 21 expression expression NN cord-342776-hkjhqgie 55 22 of of IN cord-342776-hkjhqgie 55 23 NKG2A NKG2A NNP cord-342776-hkjhqgie 55 24 in in IN cord-342776-hkjhqgie 55 25 COVID-19 COVID-19 NNP cord-342776-hkjhqgie 55 26 individuals individual NNS cord-342776-hkjhqgie 55 27 ( ( -LRB- cord-342776-hkjhqgie 55 28 20 20 CD cord-342776-hkjhqgie 55 29 ) ) -RRB- cord-342776-hkjhqgie 55 30 . . . cord-342776-hkjhqgie 56 1 More more RBR cord-342776-hkjhqgie 56 2 importantly importantly RB cord-342776-hkjhqgie 56 3 , , , cord-342776-hkjhqgie 56 4 in in IN cord-342776-hkjhqgie 56 5 patients patient NNS cord-342776-hkjhqgie 56 6 convalescing convalesce VBG cord-342776-hkjhqgie 56 7 after after IN cord-342776-hkjhqgie 56 8 therapy therapy NN cord-342776-hkjhqgie 56 9 , , , cord-342776-hkjhqgie 56 10 the the DT cord-342776-hkjhqgie 56 11 numbers number NNS cord-342776-hkjhqgie 56 12 of of IN cord-342776-hkjhqgie 56 13 NK NK NNP cord-342776-hkjhqgie 56 14 and and CC cord-342776-hkjhqgie 56 15 CD8 CD8 NNP cord-342776-hkjhqgie 56 16 + + CC cord-342776-hkjhqgie 56 17 T T NNP cord-342776-hkjhqgie 56 18 cells cell NNS cord-342776-hkjhqgie 56 19 were be VBD cord-342776-hkjhqgie 56 20 restored restore VBN cord-342776-hkjhqgie 56 21 with with IN cord-342776-hkjhqgie 56 22 reduced reduce VBN cord-342776-hkjhqgie 56 23 expression expression NN cord-342776-hkjhqgie 56 24 of of IN cord-342776-hkjhqgie 56 25 NKG2A. NKG2A. NNP cord-342776-hkjhqgie 57 1 In in IN cord-342776-hkjhqgie 57 2 addition addition NN cord-342776-hkjhqgie 57 3 , , , cord-342776-hkjhqgie 57 4 these these DT cord-342776-hkjhqgie 57 5 results result NNS cord-342776-hkjhqgie 57 6 suggested suggest VBD cord-342776-hkjhqgie 57 7 that that IN cord-342776-hkjhqgie 57 8 the the DT cord-342776-hkjhqgie 57 9 functional functional JJ cord-342776-hkjhqgie 57 10 exhaustion exhaustion NN cord-342776-hkjhqgie 57 11 of of IN cord-342776-hkjhqgie 57 12 cytotoxic cytotoxic JJ cord-342776-hkjhqgie 57 13 lymphocytes lymphocyte NNS cord-342776-hkjhqgie 57 14 was be VBD cord-342776-hkjhqgie 57 15 directly directly RB cord-342776-hkjhqgie 57 16 associated associate VBN cord-342776-hkjhqgie 57 17 with with IN cord-342776-hkjhqgie 57 18 severity severity NN cord-342776-hkjhqgie 57 19 of of IN cord-342776-hkjhqgie 57 20 SARS SARS NNP cord-342776-hkjhqgie 57 21 - - HYPH cord-342776-hkjhqgie 57 22 CoV-2 CoV-2 NNP cord-342776-hkjhqgie 57 23 infection infection NN cord-342776-hkjhqgie 57 24 . . . cord-342776-hkjhqgie 58 1 Hence hence RB cord-342776-hkjhqgie 58 2 , , , cord-342776-hkjhqgie 58 3 SARS SARS NNP cord-342776-hkjhqgie 58 4 - - HYPH cord-342776-hkjhqgie 58 5 CoV-2 CoV-2 NNP cord-342776-hkjhqgie 58 6 infection infection NN cord-342776-hkjhqgie 58 7 is be VBZ cord-342776-hkjhqgie 58 8 likely likely JJ cord-342776-hkjhqgie 58 9 to to TO cord-342776-hkjhqgie 58 10 paralyze paralyze VB cord-342776-hkjhqgie 58 11 the the DT cord-342776-hkjhqgie 58 12 antiviral antiviral JJ cord-342776-hkjhqgie 58 13 immunity immunity NN cord-342776-hkjhqgie 58 14 at at IN cord-342776-hkjhqgie 58 15 an an DT cord-342776-hkjhqgie 58 16 early early JJ cord-342776-hkjhqgie 58 17 stage stage NN cord-342776-hkjhqgie 58 18 and and CC cord-342776-hkjhqgie 58 19 contribute contribute VB cord-342776-hkjhqgie 58 20 to to IN cord-342776-hkjhqgie 58 21 progression progression NN cord-342776-hkjhqgie 58 22 and and CC cord-342776-hkjhqgie 58 23 severity severity NN cord-342776-hkjhqgie 58 24 of of IN cord-342776-hkjhqgie 58 25 the the DT cord-342776-hkjhqgie 58 26 disease disease NN cord-342776-hkjhqgie 58 27 ( ( -LRB- cord-342776-hkjhqgie 58 28 20 20 CD cord-342776-hkjhqgie 58 29 ) ) -RRB- cord-342776-hkjhqgie 59 1 ( ( -LRB- cord-342776-hkjhqgie 59 2 Figure figure NN cord-342776-hkjhqgie 59 3 1 1 CD cord-342776-hkjhqgie 59 4 ) ) -RRB- cord-342776-hkjhqgie 59 5 . . . cord-342776-hkjhqgie 60 1 In in IN cord-342776-hkjhqgie 60 2 patients patient NNS cord-342776-hkjhqgie 60 3 infected infect VBN cord-342776-hkjhqgie 60 4 with with IN cord-342776-hkjhqgie 60 5 SARS SARS NNP cord-342776-hkjhqgie 60 6 - - HYPH cord-342776-hkjhqgie 60 7 CoV-2 CoV-2 NNP cord-342776-hkjhqgie 60 8 , , , cord-342776-hkjhqgie 60 9 NKG2A nkg2a CD cord-342776-hkjhqgie 60 10 expression expression NN cord-342776-hkjhqgie 60 11 was be VBD cord-342776-hkjhqgie 60 12 increased increase VBN cord-342776-hkjhqgie 60 13 significantly significantly RB cord-342776-hkjhqgie 60 14 on on IN cord-342776-hkjhqgie 60 15 NK NK NNP cord-342776-hkjhqgie 60 16 and and CC cord-342776-hkjhqgie 60 17 CD8 CD8 NNP cord-342776-hkjhqgie 60 18 + + CC cord-342776-hkjhqgie 60 19 T T NNP cord-342776-hkjhqgie 60 20 cells cell NNS cord-342776-hkjhqgie 60 21 compared compare VBN cord-342776-hkjhqgie 60 22 to to IN cord-342776-hkjhqgie 60 23 those those DT cord-342776-hkjhqgie 60 24 in in IN cord-342776-hkjhqgie 60 25 healthy healthy JJ cord-342776-hkjhqgie 60 26 controls control NNS cord-342776-hkjhqgie 60 27 ( ( -LRB- cord-342776-hkjhqgie 60 28 20 20 CD cord-342776-hkjhqgie 60 29 ) ) -RRB- cord-342776-hkjhqgie 60 30 . . . cord-342776-hkjhqgie 61 1 Lower low JJR cord-342776-hkjhqgie 61 2 percentages percentage NNS cord-342776-hkjhqgie 61 3 of of IN cord-342776-hkjhqgie 61 4 CD107a+ CD107a+ NNP cord-342776-hkjhqgie 61 5 NK NK NNP cord-342776-hkjhqgie 61 6 , , , cord-342776-hkjhqgie 61 7 IFN IFN NNP cord-342776-hkjhqgie 61 8 - - HYPH cord-342776-hkjhqgie 61 9 γ+ γ+ NNP cord-342776-hkjhqgie 61 10 NK NK NNP cord-342776-hkjhqgie 61 11 , , , cord-342776-hkjhqgie 61 12 IL-2 IL-2 NNP cord-342776-hkjhqgie 61 13 + + CC cord-342776-hkjhqgie 61 14 NK NK NNP cord-342776-hkjhqgie 61 15 , , , cord-342776-hkjhqgie 61 16 and and CC cord-342776-hkjhqgie 61 17 TNF TNF NNP cord-342776-hkjhqgie 61 18 - - HYPH cord-342776-hkjhqgie 61 19 α+ α+ NNP cord-342776-hkjhqgie 61 20 NK NK NNP cord-342776-hkjhqgie 61 21 cells cell NNS cord-342776-hkjhqgie 61 22 and and CC cord-342776-hkjhqgie 61 23 decreased decrease VBD cord-342776-hkjhqgie 61 24 mean mean JJ cord-342776-hkjhqgie 61 25 fluorescence fluorescence NN cord-342776-hkjhqgie 61 26 intensities intensity NNS cord-342776-hkjhqgie 61 27 ( ( -LRB- cord-342776-hkjhqgie 61 28 MFI MFI NNP cord-342776-hkjhqgie 61 29 ) ) -RRB- cord-342776-hkjhqgie 61 30 of of IN cord-342776-hkjhqgie 61 31 granzyme granzyme NNP cord-342776-hkjhqgie 61 32 B+ B+ NNP cord-342776-hkjhqgie 61 33 NK NK NNP cord-342776-hkjhqgie 61 34 cells cell NNS cord-342776-hkjhqgie 61 35 were be VBD cord-342776-hkjhqgie 61 36 also also RB cord-342776-hkjhqgie 61 37 reported report VBN cord-342776-hkjhqgie 61 38 in in IN cord-342776-hkjhqgie 61 39 COVID-19 COVID-19 NNP cord-342776-hkjhqgie 61 40 individuals individual NNS cord-342776-hkjhqgie 61 41 when when WRB cord-342776-hkjhqgie 61 42 compared compare VBN cord-342776-hkjhqgie 61 43 to to IN cord-342776-hkjhqgie 61 44 healthy healthy JJ cord-342776-hkjhqgie 61 45 controls control NNS cord-342776-hkjhqgie 61 46 ( ( -LRB- cord-342776-hkjhqgie 61 47 20 20 CD cord-342776-hkjhqgie 61 48 ) ) -RRB- cord-342776-hkjhqgie 61 49 . . . cord-342776-hkjhqgie 62 1 Although although IN cord-342776-hkjhqgie 62 2 these these DT cord-342776-hkjhqgie 62 3 preliminary preliminary JJ cord-342776-hkjhqgie 62 4 results result NNS cord-342776-hkjhqgie 62 5 are be VBP cord-342776-hkjhqgie 62 6 of of IN cord-342776-hkjhqgie 62 7 significance significance NN cord-342776-hkjhqgie 62 8 , , , cord-342776-hkjhqgie 62 9 they -PRON- PRP cord-342776-hkjhqgie 62 10 still still RB cord-342776-hkjhqgie 62 11 would would MD cord-342776-hkjhqgie 62 12 need need VB cord-342776-hkjhqgie 62 13 to to TO cord-342776-hkjhqgie 62 14 be be VB cord-342776-hkjhqgie 62 15 reproduced reproduce VBN cord-342776-hkjhqgie 62 16 by by IN cord-342776-hkjhqgie 62 17 other other JJ cord-342776-hkjhqgie 62 18 laboratories laboratory NNS cord-342776-hkjhqgie 62 19 , , , cord-342776-hkjhqgie 62 20 however however RB cord-342776-hkjhqgie 62 21 , , , cord-342776-hkjhqgie 62 22 they -PRON- PRP cord-342776-hkjhqgie 62 23 clearly clearly RB cord-342776-hkjhqgie 62 24 point point VBP cord-342776-hkjhqgie 62 25 to to IN cord-342776-hkjhqgie 62 26 the the DT cord-342776-hkjhqgie 62 27 potential potential JJ cord-342776-hkjhqgie 62 28 contribution contribution NN cord-342776-hkjhqgie 62 29 of of IN cord-342776-hkjhqgie 62 30 functional functional JJ cord-342776-hkjhqgie 62 31 exhaustion exhaustion NN cord-342776-hkjhqgie 62 32 of of IN cord-342776-hkjhqgie 62 33 cytotoxic cytotoxic JJ cord-342776-hkjhqgie 62 34 lymphocytes lymphocyte NNS cord-342776-hkjhqgie 62 35 in in IN cord-342776-hkjhqgie 62 36 COVID-19 COVID-19 NNP cord-342776-hkjhqgie 62 37 disease disease NN cord-342776-hkjhqgie 62 38 ( ( -LRB- cord-342776-hkjhqgie 62 39 20 20 CD cord-342776-hkjhqgie 62 40 ) ) -RRB- cord-342776-hkjhqgie 62 41 . . . cord-342776-hkjhqgie 63 1 Thus thus RB cord-342776-hkjhqgie 63 2 , , , cord-342776-hkjhqgie 63 3 future future JJ cord-342776-hkjhqgie 63 4 studies study NNS cord-342776-hkjhqgie 63 5 should should MD cord-342776-hkjhqgie 63 6 be be VB cord-342776-hkjhqgie 63 7 focused focus VBN cord-342776-hkjhqgie 63 8 to to TO cord-342776-hkjhqgie 63 9 fully fully RB cord-342776-hkjhqgie 63 10 understand understand VB cord-342776-hkjhqgie 63 11 the the DT cord-342776-hkjhqgie 63 12 contribution contribution NN cord-342776-hkjhqgie 63 13 of of IN cord-342776-hkjhqgie 63 14 dysfunctional dysfunctional JJ cord-342776-hkjhqgie 63 15 NK NK NNP cord-342776-hkjhqgie 63 16 cells cell NNS cord-342776-hkjhqgie 63 17 in in IN cord-342776-hkjhqgie 63 18 disease disease NN cord-342776-hkjhqgie 63 19 pathogenesis pathogenesis NN cord-342776-hkjhqgie 63 20 . . . cord-342776-hkjhqgie 64 1 In in IN cord-342776-hkjhqgie 64 2 addition addition NN cord-342776-hkjhqgie 64 3 , , , cord-342776-hkjhqgie 64 4 the the DT cord-342776-hkjhqgie 64 5 underlying underlie VBG cord-342776-hkjhqgie 64 6 mechanisms mechanism NNS cord-342776-hkjhqgie 64 7 of of IN cord-342776-hkjhqgie 64 8 depletion depletion NN cord-342776-hkjhqgie 64 9 of of IN cord-342776-hkjhqgie 64 10 NK NK NNP cord-342776-hkjhqgie 64 11 cells cell NNS cord-342776-hkjhqgie 64 12 such such JJ cord-342776-hkjhqgie 64 13 as as IN cord-342776-hkjhqgie 64 14 viral viral JJ cord-342776-hkjhqgie 64 15 infection infection NN cord-342776-hkjhqgie 64 16 of of IN cord-342776-hkjhqgie 64 17 NK NK NNP cord-342776-hkjhqgie 64 18 cells cell NNS cord-342776-hkjhqgie 64 19 , , , cord-342776-hkjhqgie 64 20 mobilization mobilization NN cord-342776-hkjhqgie 64 21 and and CC cord-342776-hkjhqgie 64 22 homing homing NN cord-342776-hkjhqgie 64 23 of of IN cord-342776-hkjhqgie 64 24 NK NK NNP cord-342776-hkjhqgie 64 25 cells cell NNS cord-342776-hkjhqgie 64 26 to to IN cord-342776-hkjhqgie 64 27 the the DT cord-342776-hkjhqgie 64 28 tissues tissue NNS cord-342776-hkjhqgie 64 29 from from IN cord-342776-hkjhqgie 64 30 the the DT cord-342776-hkjhqgie 64 31 peripheral peripheral JJ cord-342776-hkjhqgie 64 32 blood blood NN cord-342776-hkjhqgie 64 33 , , , cord-342776-hkjhqgie 64 34 and and CC cord-342776-hkjhqgie 64 35 activation activation NN cord-342776-hkjhqgie 64 36 induced induce VBN cord-342776-hkjhqgie 64 37 cell cell NN cord-342776-hkjhqgie 64 38 death death NN cord-342776-hkjhqgie 64 39 would would MD cord-342776-hkjhqgie 64 40 need need VB cord-342776-hkjhqgie 64 41 to to TO cord-342776-hkjhqgie 64 42 be be VB cord-342776-hkjhqgie 64 43 investigated investigate VBN cord-342776-hkjhqgie 64 44 ( ( -LRB- cord-342776-hkjhqgie 64 45 Figure figure NN cord-342776-hkjhqgie 64 46 1 1 CD cord-342776-hkjhqgie 64 47 ) ) -RRB- cord-342776-hkjhqgie 64 48 . . . cord-342776-hkjhqgie 65 1 Neutrophils neutrophil NNS cord-342776-hkjhqgie 65 2 are be VBP cord-342776-hkjhqgie 65 3 the the DT cord-342776-hkjhqgie 65 4 most most RBS cord-342776-hkjhqgie 65 5 abundant abundant JJ cord-342776-hkjhqgie 65 6 white white JJ cord-342776-hkjhqgie 65 7 blood blood NN cord-342776-hkjhqgie 65 8 cells cell NNS cord-342776-hkjhqgie 65 9 in in IN cord-342776-hkjhqgie 65 10 the the DT cord-342776-hkjhqgie 65 11 lung lung NN cord-342776-hkjhqgie 65 12 , , , cord-342776-hkjhqgie 65 13 and and CC cord-342776-hkjhqgie 65 14 they -PRON- PRP cord-342776-hkjhqgie 65 15 are be VBP cord-342776-hkjhqgie 65 16 critical critical JJ cord-342776-hkjhqgie 65 17 effectors effector NNS cord-342776-hkjhqgie 65 18 against against IN cord-342776-hkjhqgie 65 19 infections infection NNS cord-342776-hkjhqgie 65 20 , , , cord-342776-hkjhqgie 65 21 in in IN cord-342776-hkjhqgie 65 22 particular particular JJ cord-342776-hkjhqgie 65 23 against against IN cord-342776-hkjhqgie 65 24 bacterial bacterial JJ cord-342776-hkjhqgie 65 25 infections infection NNS cord-342776-hkjhqgie 65 26 , , , cord-342776-hkjhqgie 65 27 however however RB cord-342776-hkjhqgie 65 28 they -PRON- PRP cord-342776-hkjhqgie 65 29 are be VBP cord-342776-hkjhqgie 65 30 also also RB cord-342776-hkjhqgie 65 31 capable capable JJ cord-342776-hkjhqgie 65 32 of of IN cord-342776-hkjhqgie 65 33 inducing induce VBG cord-342776-hkjhqgie 65 34 life life NN cord-342776-hkjhqgie 65 35 - - HYPH cord-342776-hkjhqgie 65 36 threatening threaten VBG cord-342776-hkjhqgie 65 37 morbidities morbidity NNS cord-342776-hkjhqgie 65 38 . . . cord-342776-hkjhqgie 66 1 Moreover moreover RB cord-342776-hkjhqgie 66 2 , , , cord-342776-hkjhqgie 66 3 Natural Natural NNP cord-342776-hkjhqgie 66 4 Killer Killer NNP cord-342776-hkjhqgie 66 5 cells cell NNS cord-342776-hkjhqgie 66 6 are be VBP cord-342776-hkjhqgie 66 7 the the DT cord-342776-hkjhqgie 66 8 most most RBS cord-342776-hkjhqgie 66 9 abundant abundant JJ cord-342776-hkjhqgie 66 10 lymphocytes lymphocyte NNS cord-342776-hkjhqgie 66 11 in in IN cord-342776-hkjhqgie 66 12 the the DT cord-342776-hkjhqgie 66 13 lung lung NN cord-342776-hkjhqgie 66 14 , , , cord-342776-hkjhqgie 66 15 and and CC cord-342776-hkjhqgie 66 16 therefore therefore RB cord-342776-hkjhqgie 66 17 , , , cord-342776-hkjhqgie 66 18 play play VB cord-342776-hkjhqgie 66 19 an an DT cord-342776-hkjhqgie 66 20 important important JJ cord-342776-hkjhqgie 66 21 role role NN cord-342776-hkjhqgie 66 22 not not RB cord-342776-hkjhqgie 66 23 only only RB cord-342776-hkjhqgie 66 24 in in IN cord-342776-hkjhqgie 66 25 curtailment curtailment NN cord-342776-hkjhqgie 66 26 of of IN cord-342776-hkjhqgie 66 27 infection infection NN cord-342776-hkjhqgie 66 28 but but CC cord-342776-hkjhqgie 66 29 also also RB cord-342776-hkjhqgie 66 30 in in IN cord-342776-hkjhqgie 66 31 exertion exertion NN cord-342776-hkjhqgie 66 32 of of IN cord-342776-hkjhqgie 66 33 significant significant JJ cord-342776-hkjhqgie 66 34 regulatory regulatory JJ cord-342776-hkjhqgie 66 35 effect effect NN cord-342776-hkjhqgie 66 36 ( ( -LRB- cord-342776-hkjhqgie 66 37 21 21 CD cord-342776-hkjhqgie 66 38 ) ) -RRB- cord-342776-hkjhqgie 66 39 . . . cord-342776-hkjhqgie 67 1 However however RB cord-342776-hkjhqgie 67 2 , , , cord-342776-hkjhqgie 67 3 little little JJ cord-342776-hkjhqgie 67 4 is be VBZ cord-342776-hkjhqgie 67 5 known know VBN cord-342776-hkjhqgie 67 6 regarding regard VBG cord-342776-hkjhqgie 67 7 the the DT cord-342776-hkjhqgie 67 8 specific specific JJ cord-342776-hkjhqgie 67 9 mechanisms mechanism NNS cord-342776-hkjhqgie 67 10 by by IN cord-342776-hkjhqgie 67 11 which which WDT cord-342776-hkjhqgie 67 12 NK NK NNP cord-342776-hkjhqgie 67 13 cells cell NNS cord-342776-hkjhqgie 67 14 maintain maintain VBP cord-342776-hkjhqgie 67 15 local local JJ cord-342776-hkjhqgie 67 16 homeostasis homeostasis NN cord-342776-hkjhqgie 67 17 . . . cord-342776-hkjhqgie 68 1 By by IN cord-342776-hkjhqgie 68 2 using use VBG cord-342776-hkjhqgie 68 3 lung lung NN cord-342776-hkjhqgie 68 4 - - HYPH cord-342776-hkjhqgie 68 5 intravital intravital NN cord-342776-hkjhqgie 68 6 microscopy microscopy NNS cord-342776-hkjhqgie 68 7 to to TO cord-342776-hkjhqgie 68 8 directly directly RB cord-342776-hkjhqgie 68 9 visualize visualize VB cord-342776-hkjhqgie 68 10 and and CC cord-342776-hkjhqgie 68 11 quantify quantify VB cord-342776-hkjhqgie 68 12 neutrophil neutrophil NN cord-342776-hkjhqgie 68 13 and and CC cord-342776-hkjhqgie 68 14 natural natural JJ cord-342776-hkjhqgie 68 15 killer killer NN cord-342776-hkjhqgie 68 16 cell cell NN cord-342776-hkjhqgie 68 17 interaction interaction NN cord-342776-hkjhqgie 68 18 within within IN cord-342776-hkjhqgie 68 19 the the DT cord-342776-hkjhqgie 68 20 lung lung NN cord-342776-hkjhqgie 68 21 of of IN cord-342776-hkjhqgie 68 22 live live JJ cord-342776-hkjhqgie 68 23 mice mouse NNS cord-342776-hkjhqgie 68 24 , , , cord-342776-hkjhqgie 68 25 the the DT cord-342776-hkjhqgie 68 26 authors author NNS cord-342776-hkjhqgie 68 27 reported report VBD cord-342776-hkjhqgie 68 28 in in IN cord-342776-hkjhqgie 68 29 a a DT cord-342776-hkjhqgie 68 30 preliminary preliminary JJ cord-342776-hkjhqgie 68 31 study study NN cord-342776-hkjhqgie 68 32 that that IN cord-342776-hkjhqgie 68 33 NK NK NNP cord-342776-hkjhqgie 68 34 cells cell NNS cord-342776-hkjhqgie 68 35 were be VBD cord-342776-hkjhqgie 68 36 greatly greatly RB cord-342776-hkjhqgie 68 37 responsible responsible JJ cord-342776-hkjhqgie 68 38 for for IN cord-342776-hkjhqgie 68 39 the the DT cord-342776-hkjhqgie 68 40 slower slow JJR cord-342776-hkjhqgie 68 41 pace pace NN cord-342776-hkjhqgie 68 42 of of IN cord-342776-hkjhqgie 68 43 scanning scanning NN cord-342776-hkjhqgie 68 44 of of IN cord-342776-hkjhqgie 68 45 endothelium endothelium NN cord-342776-hkjhqgie 68 46 by by IN cord-342776-hkjhqgie 68 47 neutrophils neutrophil NNS cord-342776-hkjhqgie 68 48 over over IN cord-342776-hkjhqgie 68 49 a a DT cord-342776-hkjhqgie 68 50 large large JJ cord-342776-hkjhqgie 68 51 area area NN cord-342776-hkjhqgie 68 52 , , , cord-342776-hkjhqgie 68 53 and and CC cord-342776-hkjhqgie 68 54 they -PRON- PRP cord-342776-hkjhqgie 68 55 were be VBD cord-342776-hkjhqgie 68 56 able able JJ cord-342776-hkjhqgie 68 57 to to TO cord-342776-hkjhqgie 68 58 reduce reduce VB cord-342776-hkjhqgie 68 59 the the DT cord-342776-hkjhqgie 68 60 number number NN cord-342776-hkjhqgie 68 61 of of IN cord-342776-hkjhqgie 68 62 neutrophils neutrophil NNS cord-342776-hkjhqgie 68 63 that that WDT cord-342776-hkjhqgie 68 64 accumulated accumulate VBD cord-342776-hkjhqgie 68 65 in in IN cord-342776-hkjhqgie 68 66 an an DT cord-342776-hkjhqgie 68 67 LPS LPS NNP cord-342776-hkjhqgie 68 68 - - HYPH cord-342776-hkjhqgie 68 69 triggered trigger VBN cord-342776-hkjhqgie 68 70 inflammatory inflammatory JJ cord-342776-hkjhqgie 68 71 challenge challenge NN cord-342776-hkjhqgie 68 72 ( ( -LRB- cord-342776-hkjhqgie 68 73 21 21 CD cord-342776-hkjhqgie 68 74 ) ) -RRB- cord-342776-hkjhqgie 68 75 . . . cord-342776-hkjhqgie 69 1 Indeed indeed RB cord-342776-hkjhqgie 69 2 , , , cord-342776-hkjhqgie 69 3 depletion depletion NN cord-342776-hkjhqgie 69 4 of of IN cord-342776-hkjhqgie 69 5 NK NK NNP cord-342776-hkjhqgie 69 6 cells cell NNS cord-342776-hkjhqgie 69 7 in in IN cord-342776-hkjhqgie 69 8 mice mouse NNS cord-342776-hkjhqgie 69 9 exhibited exhibit VBD cord-342776-hkjhqgie 69 10 severe severe JJ cord-342776-hkjhqgie 69 11 respiratory respiratory JJ cord-342776-hkjhqgie 69 12 distress distress NN cord-342776-hkjhqgie 69 13 associated associate VBN cord-342776-hkjhqgie 69 14 with with IN cord-342776-hkjhqgie 69 15 protein protein NN cord-342776-hkjhqgie 69 16 - - HYPH cord-342776-hkjhqgie 69 17 rich rich JJ cord-342776-hkjhqgie 69 18 , , , cord-342776-hkjhqgie 69 19 high high JJ cord-342776-hkjhqgie 69 20 - - HYPH cord-342776-hkjhqgie 69 21 permeability permeability NN cord-342776-hkjhqgie 69 22 alveolar alveolar NN cord-342776-hkjhqgie 69 23 edema edema NN cord-342776-hkjhqgie 69 24 accompanied accompany VBN cord-342776-hkjhqgie 69 25 by by IN cord-342776-hkjhqgie 69 26 neutrophil neutrophil NN cord-342776-hkjhqgie 69 27 infiltration infiltration NN cord-342776-hkjhqgie 69 28 in in IN cord-342776-hkjhqgie 69 29 myocardial myocardial JJ cord-342776-hkjhqgie 69 30 infarction infarction NN cord-342776-hkjhqgie 69 31 model model NN cord-342776-hkjhqgie 69 32 ( ( -LRB- cord-342776-hkjhqgie 69 33 22 22 CD cord-342776-hkjhqgie 69 34 ) ) -RRB- cord-342776-hkjhqgie 69 35 . . . cord-342776-hkjhqgie 70 1 Thus thus RB cord-342776-hkjhqgie 70 2 , , , cord-342776-hkjhqgie 70 3 NK NK NNP cord-342776-hkjhqgie 70 4 cells cell NNS cord-342776-hkjhqgie 70 5 are be VBP cord-342776-hkjhqgie 70 6 important important JJ cord-342776-hkjhqgie 70 7 effectors effector NNS cord-342776-hkjhqgie 70 8 in in IN cord-342776-hkjhqgie 70 9 not not RB cord-342776-hkjhqgie 70 10 only only RB cord-342776-hkjhqgie 70 11 combating combat VBG cord-342776-hkjhqgie 70 12 the the DT cord-342776-hkjhqgie 70 13 infection infection NN cord-342776-hkjhqgie 70 14 directly directly RB cord-342776-hkjhqgie 70 15 but but CC cord-342776-hkjhqgie 70 16 also also RB cord-342776-hkjhqgie 70 17 indirectly indirectly RB cord-342776-hkjhqgie 70 18 by by IN cord-342776-hkjhqgie 70 19 activating activate VBG cord-342776-hkjhqgie 70 20 the the DT cord-342776-hkjhqgie 70 21 local local JJ cord-342776-hkjhqgie 70 22 inflammatory inflammatory JJ cord-342776-hkjhqgie 70 23 processes process NNS cord-342776-hkjhqgie 70 24 to to TO cord-342776-hkjhqgie 70 25 curtail curtail VB cord-342776-hkjhqgie 70 26 infection infection NN cord-342776-hkjhqgie 70 27 . . . cord-342776-hkjhqgie 71 1 In in IN cord-342776-hkjhqgie 71 2 addition addition NN cord-342776-hkjhqgie 71 3 , , , cord-342776-hkjhqgie 71 4 they -PRON- PRP cord-342776-hkjhqgie 71 5 are be VBP cord-342776-hkjhqgie 71 6 also also RB cord-342776-hkjhqgie 71 7 able able JJ cord-342776-hkjhqgie 71 8 to to TO cord-342776-hkjhqgie 71 9 limit limit VB cord-342776-hkjhqgie 71 10 local local JJ cord-342776-hkjhqgie 71 11 immune immune JJ cord-342776-hkjhqgie 71 12 activation activation NN cord-342776-hkjhqgie 71 13 in in IN cord-342776-hkjhqgie 71 14 the the DT cord-342776-hkjhqgie 71 15 lung lung NN cord-342776-hkjhqgie 71 16 to to IN cord-342776-hkjhqgie 71 17 a a DT cord-342776-hkjhqgie 71 18 manageable manageable JJ cord-342776-hkjhqgie 71 19 level level NN cord-342776-hkjhqgie 71 20 without without IN cord-342776-hkjhqgie 71 21 causing cause VBG cord-342776-hkjhqgie 71 22 or or CC cord-342776-hkjhqgie 71 23 allowing allow VBG cord-342776-hkjhqgie 71 24 significant significant JJ cord-342776-hkjhqgie 71 25 pathologies pathology NNS cord-342776-hkjhqgie 71 26 to to TO cord-342776-hkjhqgie 71 27 be be VB cord-342776-hkjhqgie 71 28 induced induce VBN cord-342776-hkjhqgie 71 29 by by IN cord-342776-hkjhqgie 71 30 other other JJ cord-342776-hkjhqgie 71 31 immune immune JJ cord-342776-hkjhqgie 71 32 effectors effector NNS cord-342776-hkjhqgie 71 33 ( ( -LRB- cord-342776-hkjhqgie 71 34 Figure figure NN cord-342776-hkjhqgie 71 35 1 1 CD cord-342776-hkjhqgie 71 36 ) ) -RRB- cord-342776-hkjhqgie 71 37 . . . cord-342776-hkjhqgie 72 1 Thus thus RB cord-342776-hkjhqgie 72 2 , , , cord-342776-hkjhqgie 72 3 NK NK NNP cord-342776-hkjhqgie 72 4 cells cell NNS cord-342776-hkjhqgie 72 5 are be VBP cord-342776-hkjhqgie 72 6 important important JJ cord-342776-hkjhqgie 72 7 in in IN cord-342776-hkjhqgie 72 8 keeping keep VBG cord-342776-hkjhqgie 72 9 the the DT cord-342776-hkjhqgie 72 10 balance balance NN cord-342776-hkjhqgie 72 11 of of IN cord-342776-hkjhqgie 72 12 immune immune JJ cord-342776-hkjhqgie 72 13 activation activation NN cord-342776-hkjhqgie 72 14 in in IN cord-342776-hkjhqgie 72 15 such such PDT cord-342776-hkjhqgie 72 16 a a DT cord-342776-hkjhqgie 72 17 way way NN cord-342776-hkjhqgie 72 18 that that IN cord-342776-hkjhqgie 72 19 sufficient sufficient JJ cord-342776-hkjhqgie 72 20 levels level NNS cord-342776-hkjhqgie 72 21 of of IN cord-342776-hkjhqgie 72 22 activation activation NN cord-342776-hkjhqgie 72 23 will will MD cord-342776-hkjhqgie 72 24 ensue ensue VB cord-342776-hkjhqgie 72 25 to to TO cord-342776-hkjhqgie 72 26 remove remove VB cord-342776-hkjhqgie 72 27 the the DT cord-342776-hkjhqgie 72 28 infection infection NN cord-342776-hkjhqgie 72 29 in in IN cord-342776-hkjhqgie 72 30 the the DT cord-342776-hkjhqgie 72 31 presence presence NN cord-342776-hkjhqgie 72 32 of of IN cord-342776-hkjhqgie 72 33 finely finely RB cord-342776-hkjhqgie 72 34 tuned tune VBN cord-342776-hkjhqgie 72 35 inflammatory inflammatory JJ cord-342776-hkjhqgie 72 36 processes process NNS cord-342776-hkjhqgie 72 37 to to TO cord-342776-hkjhqgie 72 38 avoid avoid VB cord-342776-hkjhqgie 72 39 local local JJ cord-342776-hkjhqgie 72 40 tissue tissue NN cord-342776-hkjhqgie 72 41 damage damage NN cord-342776-hkjhqgie 72 42 . . . cord-342776-hkjhqgie 73 1 As as IN cord-342776-hkjhqgie 73 2 mentioned mention VBN cord-342776-hkjhqgie 73 3 above above IN cord-342776-hkjhqgie 73 4 the the DT cord-342776-hkjhqgie 73 5 infectious infectious JJ cord-342776-hkjhqgie 73 6 agent agent NN cord-342776-hkjhqgie 73 7 of of IN cord-342776-hkjhqgie 73 8 COVID-19 COVID-19 NNP cord-342776-hkjhqgie 73 9 disease disease NN cord-342776-hkjhqgie 73 10 depletes deplete VBZ cord-342776-hkjhqgie 73 11 NK NK NNP cord-342776-hkjhqgie 73 12 cells cell NNS cord-342776-hkjhqgie 73 13 in in IN cord-342776-hkjhqgie 73 14 the the DT cord-342776-hkjhqgie 73 15 peripheral peripheral JJ cord-342776-hkjhqgie 73 16 blood blood NN cord-342776-hkjhqgie 73 17 , , , cord-342776-hkjhqgie 73 18 and and CC cord-342776-hkjhqgie 73 19 potentially potentially RB cord-342776-hkjhqgie 73 20 even even RB cord-342776-hkjhqgie 73 21 in in IN cord-342776-hkjhqgie 73 22 the the DT cord-342776-hkjhqgie 73 23 lung lung NN cord-342776-hkjhqgie 73 24 tissues tissue NNS cord-342776-hkjhqgie 73 25 of of IN cord-342776-hkjhqgie 73 26 patients patient NNS cord-342776-hkjhqgie 73 27 , , , cord-342776-hkjhqgie 73 28 thereby thereby RB cord-342776-hkjhqgie 73 29 , , , cord-342776-hkjhqgie 73 30 disabling disable VBG cord-342776-hkjhqgie 73 31 and and CC cord-342776-hkjhqgie 73 32 depleting deplete VBG cord-342776-hkjhqgie 73 33 the the DT cord-342776-hkjhqgie 73 34 core core NN cord-342776-hkjhqgie 73 35 immune immune JJ cord-342776-hkjhqgie 73 36 effectors effector NNS cord-342776-hkjhqgie 73 37 necessary necessary JJ cord-342776-hkjhqgie 73 38 to to TO cord-342776-hkjhqgie 73 39 remove remove VB cord-342776-hkjhqgie 73 40 the the DT cord-342776-hkjhqgie 73 41 virus virus NN cord-342776-hkjhqgie 73 42 and and CC cord-342776-hkjhqgie 73 43 regulate regulate VB cord-342776-hkjhqgie 73 44 uncontrolled uncontrolled JJ cord-342776-hkjhqgie 73 45 immune immune JJ cord-342776-hkjhqgie 73 46 activation activation NN cord-342776-hkjhqgie 73 47 . . . cord-342776-hkjhqgie 74 1 Indeed indeed RB cord-342776-hkjhqgie 74 2 , , , cord-342776-hkjhqgie 74 3 NK NK NNP cord-342776-hkjhqgie 74 4 cells cell NNS cord-342776-hkjhqgie 74 5 are be VBP cord-342776-hkjhqgie 74 6 the the DT cord-342776-hkjhqgie 74 7 army army NN cord-342776-hkjhqgie 74 8 generals general NNS cord-342776-hkjhqgie 74 9 of of IN cord-342776-hkjhqgie 74 10 the the DT cord-342776-hkjhqgie 74 11 immune immune JJ cord-342776-hkjhqgie 74 12 effectors effector NNS cord-342776-hkjhqgie 74 13 which which WDT cord-342776-hkjhqgie 74 14 bring bring VBP cord-342776-hkjhqgie 74 15 order order NN cord-342776-hkjhqgie 74 16 and and CC cord-342776-hkjhqgie 74 17 discipline discipline NN cord-342776-hkjhqgie 74 18 to to IN cord-342776-hkjhqgie 74 19 the the DT cord-342776-hkjhqgie 74 20 infected infected JJ cord-342776-hkjhqgie 74 21 tissue tissue NN cord-342776-hkjhqgie 74 22 microenvironment microenvironment NN cord-342776-hkjhqgie 74 23 . . . cord-342776-hkjhqgie 75 1 Without without IN cord-342776-hkjhqgie 75 2 the the DT cord-342776-hkjhqgie 75 3 NK NK NNP cord-342776-hkjhqgie 75 4 cells cell NNS cord-342776-hkjhqgie 75 5 it -PRON- PRP cord-342776-hkjhqgie 75 6 is be VBZ cord-342776-hkjhqgie 75 7 likely likely JJ cord-342776-hkjhqgie 75 8 that that IN cord-342776-hkjhqgie 75 9 immune immune JJ cord-342776-hkjhqgie 75 10 anarchy anarchy NN cord-342776-hkjhqgie 75 11 may may MD cord-342776-hkjhqgie 75 12 ensue ensue VB cord-342776-hkjhqgie 75 13 and and CC cord-342776-hkjhqgie 75 14 result result VB cord-342776-hkjhqgie 75 15 in in IN cord-342776-hkjhqgie 75 16 the the DT cord-342776-hkjhqgie 75 17 uncontrolled uncontrolled JJ cord-342776-hkjhqgie 75 18 expansion expansion NN cord-342776-hkjhqgie 75 19 and and CC cord-342776-hkjhqgie 75 20 activation activation NN cord-342776-hkjhqgie 75 21 of of IN cord-342776-hkjhqgie 75 22 other other JJ cord-342776-hkjhqgie 75 23 immune immune JJ cord-342776-hkjhqgie 75 24 effectors effector NNS cord-342776-hkjhqgie 75 25 ( ( -LRB- cord-342776-hkjhqgie 75 26 16 16 CD cord-342776-hkjhqgie 75 27 ) ) -RRB- cord-342776-hkjhqgie 75 28 ( ( -LRB- cord-342776-hkjhqgie 75 29 17 17 CD cord-342776-hkjhqgie 75 30 ) ) -RRB- cord-342776-hkjhqgie 75 31 ( ( -LRB- cord-342776-hkjhqgie 75 32 18 18 CD cord-342776-hkjhqgie 75 33 ) ) -RRB- cord-342776-hkjhqgie 75 34 ( ( -LRB- cord-342776-hkjhqgie 75 35 19 19 CD cord-342776-hkjhqgie 75 36 ) ) -RRB- cord-342776-hkjhqgie 75 37 . . . cord-342776-hkjhqgie 76 1 We -PRON- PRP cord-342776-hkjhqgie 76 2 have have VBP cord-342776-hkjhqgie 76 3 previously previously RB cord-342776-hkjhqgie 76 4 shown show VBN cord-342776-hkjhqgie 76 5 that that IN cord-342776-hkjhqgie 76 6 NK NK NNP cord-342776-hkjhqgie 76 7 cells cell NNS cord-342776-hkjhqgie 76 8 also also RB cord-342776-hkjhqgie 76 9 curtail curtail VBP cord-342776-hkjhqgie 76 10 the the DT cord-342776-hkjhqgie 76 11 numbers number NNS cord-342776-hkjhqgie 76 12 of of IN cord-342776-hkjhqgie 76 13 CD4 CD4 NNP cord-342776-hkjhqgie 76 14 + + CC cord-342776-hkjhqgie 76 15 T T NNP cord-342776-hkjhqgie 76 16 cells cell NNS cord-342776-hkjhqgie 76 17 and and CC cord-342776-hkjhqgie 76 18 expand expand VB cord-342776-hkjhqgie 76 19 CD8 CD8 NNP cord-342776-hkjhqgie 76 20 + + CC cord-342776-hkjhqgie 76 21 T T NNP cord-342776-hkjhqgie 76 22 cells cell NNS cord-342776-hkjhqgie 76 23 ( ( -LRB- cord-342776-hkjhqgie 76 24 23 23 CD cord-342776-hkjhqgie 76 25 , , , cord-342776-hkjhqgie 76 26 24 24 CD cord-342776-hkjhqgie 76 27 ) ) -RRB- cord-342776-hkjhqgie 76 28 and and CC cord-342776-hkjhqgie 76 29 ( ( -LRB- cord-342776-hkjhqgie 76 30 manuscript manuscript NN cord-342776-hkjhqgie 76 31 submitted submit VBD cord-342776-hkjhqgie 76 32 ) ) -RRB- cord-342776-hkjhqgie 76 33 . . . cord-342776-hkjhqgie 77 1 Therefore therefore RB cord-342776-hkjhqgie 77 2 , , , cord-342776-hkjhqgie 77 3 lack lack NN cord-342776-hkjhqgie 77 4 of of IN cord-342776-hkjhqgie 77 5 NK NK NNP cord-342776-hkjhqgie 77 6 cells cell NNS cord-342776-hkjhqgie 77 7 may may MD cord-342776-hkjhqgie 77 8 also also RB cord-342776-hkjhqgie 77 9 result result VB cord-342776-hkjhqgie 77 10 in in IN cord-342776-hkjhqgie 77 11 the the DT cord-342776-hkjhqgie 77 12 decrease decrease NN cord-342776-hkjhqgie 77 13 expansion expansion NN cord-342776-hkjhqgie 77 14 of of IN cord-342776-hkjhqgie 77 15 CD8 CD8 NNP cord-342776-hkjhqgie 77 16 + + CC cord-342776-hkjhqgie 77 17 T T NNP cord-342776-hkjhqgie 77 18 cells cell NNS cord-342776-hkjhqgie 77 19 as as IN cord-342776-hkjhqgie 77 20 seen see VBN cord-342776-hkjhqgie 77 21 in in IN cord-342776-hkjhqgie 77 22 COVID-19 covid-19 JJ cord-342776-hkjhqgie 77 23 individuals individual NNS cord-342776-hkjhqgie 77 24 ( ( -LRB- cord-342776-hkjhqgie 77 25 16 16 CD cord-342776-hkjhqgie 77 26 ) ) -RRB- cord-342776-hkjhqgie 77 27 ( ( -LRB- cord-342776-hkjhqgie 77 28 17 17 CD cord-342776-hkjhqgie 77 29 ) ) -RRB- cord-342776-hkjhqgie 77 30 ( ( -LRB- cord-342776-hkjhqgie 77 31 18 18 CD cord-342776-hkjhqgie 77 32 ) ) -RRB- cord-342776-hkjhqgie 77 33 ( ( -LRB- cord-342776-hkjhqgie 77 34 19 19 CD cord-342776-hkjhqgie 77 35 ) ) -RRB- cord-342776-hkjhqgie 77 36 ( ( -LRB- cord-342776-hkjhqgie 77 37 Figure figure NN cord-342776-hkjhqgie 77 38 1 1 CD cord-342776-hkjhqgie 77 39 ) ) -RRB- cord-342776-hkjhqgie 77 40 . . . cord-342776-hkjhqgie 78 1 Thus thus RB cord-342776-hkjhqgie 78 2 , , , cord-342776-hkjhqgie 78 3 it -PRON- PRP cord-342776-hkjhqgie 78 4 is be VBZ cord-342776-hkjhqgie 78 5 no no DT cord-342776-hkjhqgie 78 6 surprise surprise NN cord-342776-hkjhqgie 78 7 that that IN cord-342776-hkjhqgie 78 8 patients patient NNS cord-342776-hkjhqgie 78 9 suffering suffer VBG cord-342776-hkjhqgie 78 10 from from IN cord-342776-hkjhqgie 78 11 COVID-19 COVID-19 NNP cord-342776-hkjhqgie 78 12 disease disease NN cord-342776-hkjhqgie 78 13 have have VBP cord-342776-hkjhqgie 78 14 greater great JJR cord-342776-hkjhqgie 78 15 CD4 CD4 NNP cord-342776-hkjhqgie 78 16 / / SYM cord-342776-hkjhqgie 78 17 CD8 CD8 NNP cord-342776-hkjhqgie 78 18 ratios ratio NNS cord-342776-hkjhqgie 78 19 as as IN cord-342776-hkjhqgie 78 20 reported report VBD cord-342776-hkjhqgie 78 21 previously previously RB cord-342776-hkjhqgie 78 22 . . . cord-342776-hkjhqgie 79 1 The the DT cord-342776-hkjhqgie 79 2 COVID-19 COVID-19 NNP cord-342776-hkjhqgie 79 3 individuals individual NNS cord-342776-hkjhqgie 79 4 suffer suffer VBP cord-342776-hkjhqgie 79 5 from from IN cord-342776-hkjhqgie 79 6 increased increase VBN cord-342776-hkjhqgie 79 7 viral viral JJ cord-342776-hkjhqgie 79 8 replication replication NN cord-342776-hkjhqgie 79 9 as as RB cord-342776-hkjhqgie 79 10 well well RB cord-342776-hkjhqgie 79 11 as as IN cord-342776-hkjhqgie 79 12 uncontrolled uncontrolled JJ cord-342776-hkjhqgie 79 13 inflammation inflammation NN cord-342776-hkjhqgie 79 14 resulting result VBG cord-342776-hkjhqgie 79 15 in in IN cord-342776-hkjhqgie 79 16 cytokine cytokine NN cord-342776-hkjhqgie 79 17 storm storm NN cord-342776-hkjhqgie 79 18 and and CC cord-342776-hkjhqgie 79 19 widespread widespread JJ cord-342776-hkjhqgie 79 20 tissue tissue NN cord-342776-hkjhqgie 79 21 and and CC cord-342776-hkjhqgie 79 22 organ organ NN cord-342776-hkjhqgie 79 23 damage damage NN cord-342776-hkjhqgie 79 24 ( ( -LRB- cord-342776-hkjhqgie 79 25 25 25 CD cord-342776-hkjhqgie 79 26 ) ) -RRB- cord-342776-hkjhqgie 79 27 ( ( -LRB- cord-342776-hkjhqgie 79 28 26 26 CD cord-342776-hkjhqgie 79 29 ) ) -RRB- cord-342776-hkjhqgie 79 30 ( ( -LRB- cord-342776-hkjhqgie 79 31 27 27 CD cord-342776-hkjhqgie 79 32 ) ) -RRB- cord-342776-hkjhqgie 79 33 . . . cord-342776-hkjhqgie 80 1 NK NK NNP cord-342776-hkjhqgie 80 2 cells cell NNS cord-342776-hkjhqgie 80 3 are be VBP cord-342776-hkjhqgie 80 4 known know VBN cord-342776-hkjhqgie 80 5 to to TO cord-342776-hkjhqgie 80 6 mediate mediate VB cord-342776-hkjhqgie 80 7 cytotoxicity cytotoxicity NN cord-342776-hkjhqgie 80 8 , , , cord-342776-hkjhqgie 80 9 and and CC cord-342776-hkjhqgie 80 10 regulate regulate VB cord-342776-hkjhqgie 80 11 both both CC cord-342776-hkjhqgie 80 12 the the DT cord-342776-hkjhqgie 80 13 innate innate JJ cord-342776-hkjhqgie 80 14 and and CC cord-342776-hkjhqgie 80 15 adaptive adaptive JJ cord-342776-hkjhqgie 80 16 immune immune JJ cord-342776-hkjhqgie 80 17 functions function NNS cord-342776-hkjhqgie 80 18 through through IN cord-342776-hkjhqgie 80 19 the the DT cord-342776-hkjhqgie 80 20 release release NN cord-342776-hkjhqgie 80 21 of of IN cord-342776-hkjhqgie 80 22 many many JJ cord-342776-hkjhqgie 80 23 pro pro JJ cord-342776-hkjhqgie 80 24 - - JJ cord-342776-hkjhqgie 80 25 and and CC cord-342776-hkjhqgie 80 26 anti anti JJ cord-342776-hkjhqgie 80 27 - - JJ cord-342776-hkjhqgie 80 28 inflammatory inflammatory JJ cord-342776-hkjhqgie 80 29 growth growth NN cord-342776-hkjhqgie 80 30 factors factor NNS cord-342776-hkjhqgie 80 31 , , , cord-342776-hkjhqgie 80 32 cytokines cytokine NNS cord-342776-hkjhqgie 80 33 and and CC cord-342776-hkjhqgie 80 34 chemokines chemokine NNS cord-342776-hkjhqgie 80 35 ( ( -LRB- cord-342776-hkjhqgie 80 36 16 16 CD cord-342776-hkjhqgie 80 37 - - SYM cord-342776-hkjhqgie 80 38 19 19 CD cord-342776-hkjhqgie 80 39 , , , cord-342776-hkjhqgie 80 40 28 28 CD cord-342776-hkjhqgie 80 41 , , , cord-342776-hkjhqgie 80 42 29 29 CD cord-342776-hkjhqgie 80 43 ) ) -RRB- cord-342776-hkjhqgie 80 44 . . . cord-342776-hkjhqgie 81 1 They -PRON- PRP cord-342776-hkjhqgie 81 2 constitute constitute VBP cord-342776-hkjhqgie 81 3 5 5 CD cord-342776-hkjhqgie 81 4 - - SYM cord-342776-hkjhqgie 81 5 15 15 CD cord-342776-hkjhqgie 81 6 % % NN cord-342776-hkjhqgie 81 7 of of IN cord-342776-hkjhqgie 81 8 the the DT cord-342776-hkjhqgie 81 9 peripheral peripheral JJ cord-342776-hkjhqgie 81 10 blood blood NN cord-342776-hkjhqgie 81 11 mononuclear mononuclear NN cord-342776-hkjhqgie 81 12 cells cell NNS cord-342776-hkjhqgie 81 13 ( ( -LRB- cord-342776-hkjhqgie 81 14 PBMCs pbmc NNS cord-342776-hkjhqgie 81 15 ) ) -RRB- cord-342776-hkjhqgie 81 16 , , , cord-342776-hkjhqgie 81 17 and and CC cord-342776-hkjhqgie 81 18 are be VBP cord-342776-hkjhqgie 81 19 cytotoxic cytotoxic JJ cord-342776-hkjhqgie 81 20 effectors effector NNS cord-342776-hkjhqgie 81 21 in in IN cord-342776-hkjhqgie 81 22 the the DT cord-342776-hkjhqgie 81 23 blood blood NN cord-342776-hkjhqgie 81 24 of of IN cord-342776-hkjhqgie 81 25 healthy healthy JJ cord-342776-hkjhqgie 81 26 individuals individual NNS cord-342776-hkjhqgie 81 27 with with IN cord-342776-hkjhqgie 81 28 the the DT cord-342776-hkjhqgie 81 29 ability ability NN cord-342776-hkjhqgie 81 30 to to TO cord-342776-hkjhqgie 81 31 recognize recognize VB cord-342776-hkjhqgie 81 32 and and CC cord-342776-hkjhqgie 81 33 lyse lyse VB cord-342776-hkjhqgie 81 34 virally virally RB cord-342776-hkjhqgie 81 35 infected infect VBN cord-342776-hkjhqgie 81 36 cells cell NNS cord-342776-hkjhqgie 81 37 , , , cord-342776-hkjhqgie 81 38 including include VBG cord-342776-hkjhqgie 81 39 SARS SARS NNP cord-342776-hkjhqgie 81 40 - - HYPH cord-342776-hkjhqgie 81 41 CoV-2 CoV-2 NNP cord-342776-hkjhqgie 81 42 infected infected JJ cord-342776-hkjhqgie 81 43 cells cell NNS cord-342776-hkjhqgie 81 44 and and CC cord-342776-hkjhqgie 81 45 a a DT cord-342776-hkjhqgie 81 46 number number NN cord-342776-hkjhqgie 81 47 of of IN cord-342776-hkjhqgie 81 48 different different JJ cord-342776-hkjhqgie 81 49 cancer cancer NN cord-342776-hkjhqgie 81 50 stem stem NN cord-342776-hkjhqgie 81 51 cells cell NNS cord-342776-hkjhqgie 81 52 ( ( -LRB- cord-342776-hkjhqgie 81 53 CSCs CSCs NNP cord-342776-hkjhqgie 81 54 ) ) -RRB- cord-342776-hkjhqgie 81 55 and and CC cord-342776-hkjhqgie 81 56 undifferentiated undifferentiated JJ cord-342776-hkjhqgie 81 57 or or CC cord-342776-hkjhqgie 81 58 poorly poorly RB cord-342776-hkjhqgie 81 59 differentiated differentiate VBN cord-342776-hkjhqgie 81 60 tumors tumor NNS cord-342776-hkjhqgie 81 61 which which WDT cord-342776-hkjhqgie 81 62 constitute constitute VBP cord-342776-hkjhqgie 81 63 the the DT cord-342776-hkjhqgie 81 64 most most RBS cord-342776-hkjhqgie 81 65 aggressive aggressive JJ cord-342776-hkjhqgie 81 66 subpopulations subpopulation NNS cord-342776-hkjhqgie 81 67 of of IN cord-342776-hkjhqgie 81 68 the the DT cord-342776-hkjhqgie 81 69 tumors tumor NNS cord-342776-hkjhqgie 81 70 . . . cord-342776-hkjhqgie 82 1 Morphologically Morphologically NNP cord-342776-hkjhqgie 82 2 , , , cord-342776-hkjhqgie 82 3 NK NK NNP cord-342776-hkjhqgie 82 4 cells cell NNS cord-342776-hkjhqgie 82 5 are be VBP cord-342776-hkjhqgie 82 6 large large JJ cord-342776-hkjhqgie 82 7 granular granular JJ cord-342776-hkjhqgie 82 8 lymphocytes lymphocyte NNS cord-342776-hkjhqgie 82 9 that that WDT cord-342776-hkjhqgie 82 10 develop develop VBP cord-342776-hkjhqgie 82 11 in in IN cord-342776-hkjhqgie 82 12 the the DT cord-342776-hkjhqgie 82 13 bone bone NN cord-342776-hkjhqgie 82 14 marrow marrow NN cord-342776-hkjhqgie 82 15 . . . cord-342776-hkjhqgie 83 1 After after IN cord-342776-hkjhqgie 83 2 development development NN cord-342776-hkjhqgie 83 3 , , , cord-342776-hkjhqgie 83 4 the the DT cord-342776-hkjhqgie 83 5 majority majority NN cord-342776-hkjhqgie 83 6 of of IN cord-342776-hkjhqgie 83 7 NK NK NNP cord-342776-hkjhqgie 83 8 cells cell NNS cord-342776-hkjhqgie 83 9 are be VBP cord-342776-hkjhqgie 83 10 found find VBN cord-342776-hkjhqgie 83 11 in in IN cord-342776-hkjhqgie 83 12 peripheral peripheral JJ cord-342776-hkjhqgie 83 13 blood blood NN cord-342776-hkjhqgie 83 14 as as IN cord-342776-hkjhqgie 83 15 the the DT cord-342776-hkjhqgie 83 16 third third RB cord-342776-hkjhqgie 83 17 largest large JJS cord-342776-hkjhqgie 83 18 lymphocyte lymphocyte NN cord-342776-hkjhqgie 83 19 population population NN cord-342776-hkjhqgie 83 20 , , , cord-342776-hkjhqgie 83 21 next next RB cord-342776-hkjhqgie 83 22 to to IN cord-342776-hkjhqgie 83 23 B B NNP cord-342776-hkjhqgie 83 24 and and CC cord-342776-hkjhqgie 83 25 T t NN cord-342776-hkjhqgie 83 26 cells cell NNS cord-342776-hkjhqgie 83 27 ( ( -LRB- cord-342776-hkjhqgie 83 28 30 30 CD cord-342776-hkjhqgie 83 29 ) ) -RRB- cord-342776-hkjhqgie 83 30 . . . cord-342776-hkjhqgie 84 1 Moreover moreover RB cord-342776-hkjhqgie 84 2 , , , cord-342776-hkjhqgie 84 3 NK NK NNP cord-342776-hkjhqgie 84 4 cells cell NNS cord-342776-hkjhqgie 84 5 are be VBP cord-342776-hkjhqgie 84 6 also also RB cord-342776-hkjhqgie 84 7 found find VBN cord-342776-hkjhqgie 84 8 in in IN cord-342776-hkjhqgie 84 9 the the DT cord-342776-hkjhqgie 84 10 tissues tissue NNS cord-342776-hkjhqgie 84 11 such such JJ cord-342776-hkjhqgie 84 12 as as IN cord-342776-hkjhqgie 84 13 in in IN cord-342776-hkjhqgie 84 14 healthy healthy JJ cord-342776-hkjhqgie 84 15 skin skin NN cord-342776-hkjhqgie 84 16 , , , cord-342776-hkjhqgie 84 17 gut gut NN cord-342776-hkjhqgie 84 18 , , , cord-342776-hkjhqgie 84 19 lung lung NN cord-342776-hkjhqgie 84 20 , , , cord-342776-hkjhqgie 84 21 liver liver NN cord-342776-hkjhqgie 84 22 , , , cord-342776-hkjhqgie 84 23 lymphoid lymphoid JJ cord-342776-hkjhqgie 84 24 organs organ NNS cord-342776-hkjhqgie 84 25 and and CC cord-342776-hkjhqgie 84 26 uterus uterus NN cord-342776-hkjhqgie 84 27 during during IN cord-342776-hkjhqgie 84 28 pregnancy pregnancy NN cord-342776-hkjhqgie 84 29 ( ( -LRB- cord-342776-hkjhqgie 84 30 31 31 CD cord-342776-hkjhqgie 84 31 ) ) -RRB- cord-342776-hkjhqgie 84 32 . . . cord-342776-hkjhqgie 85 1 NK NK NNP cord-342776-hkjhqgie 85 2 cells cell NNS cord-342776-hkjhqgie 85 3 have have VBP cord-342776-hkjhqgie 85 4 two two CD cord-342776-hkjhqgie 85 5 different different JJ cord-342776-hkjhqgie 85 6 effector effector NN cord-342776-hkjhqgie 85 7 functions function NNS cord-342776-hkjhqgie 85 8 : : : cord-342776-hkjhqgie 85 9 cytotoxicity cytotoxicity NN cord-342776-hkjhqgie 85 10 and and CC cord-342776-hkjhqgie 85 11 cytokine cytokine NN cord-342776-hkjhqgie 85 12 release release NN cord-342776-hkjhqgie 85 13 . . . cord-342776-hkjhqgie 86 1 In in IN cord-342776-hkjhqgie 86 2 contrast contrast NN cord-342776-hkjhqgie 86 3 to to IN cord-342776-hkjhqgie 86 4 CD8 CD8 NNP cord-342776-hkjhqgie 86 5 + + CC cord-342776-hkjhqgie 86 6 cytotoxic cytotoxic JJ cord-342776-hkjhqgie 86 7 T t NN cord-342776-hkjhqgie 86 8 lymphocytes lymphocyte NNS cord-342776-hkjhqgie 86 9 , , , cord-342776-hkjhqgie 86 10 NK NK NNP cord-342776-hkjhqgie 86 11 cells cell NNS cord-342776-hkjhqgie 86 12 do do VBP cord-342776-hkjhqgie 86 13 not not RB cord-342776-hkjhqgie 86 14 need need VB cord-342776-hkjhqgie 86 15 priming prime VBG cord-342776-hkjhqgie 86 16 with with IN cord-342776-hkjhqgie 86 17 antigen antigen NN cord-342776-hkjhqgie 86 18 in in IN cord-342776-hkjhqgie 86 19 order order NN cord-342776-hkjhqgie 86 20 to to TO cord-342776-hkjhqgie 86 21 kill kill VB cord-342776-hkjhqgie 86 22 their -PRON- PRP$ cord-342776-hkjhqgie 86 23 target target NN cord-342776-hkjhqgie 86 24 cells cell NNS cord-342776-hkjhqgie 86 25 . . . cord-342776-hkjhqgie 87 1 Their -PRON- PRP$ cord-342776-hkjhqgie 87 2 function function NN cord-342776-hkjhqgie 87 3 is be VBZ cord-342776-hkjhqgie 87 4 regulated regulate VBN cord-342776-hkjhqgie 87 5 by by IN cord-342776-hkjhqgie 87 6 the the DT cord-342776-hkjhqgie 87 7 sum sum NN cord-342776-hkjhqgie 87 8 of of IN cord-342776-hkjhqgie 87 9 interactions interaction NNS cord-342776-hkjhqgie 87 10 between between IN cord-342776-hkjhqgie 87 11 activating activate VBG cord-342776-hkjhqgie 87 12 and and CC cord-342776-hkjhqgie 87 13 inhibitory inhibitory JJ cord-342776-hkjhqgie 87 14 receptors receptor NNS cord-342776-hkjhqgie 87 15 on on IN cord-342776-hkjhqgie 87 16 their -PRON- PRP$ cord-342776-hkjhqgie 87 17 surface surface NN cord-342776-hkjhqgie 87 18 and and CC cord-342776-hkjhqgie 87 19 the the DT cord-342776-hkjhqgie 87 20 ligands ligand NNS cord-342776-hkjhqgie 87 21 on on IN cord-342776-hkjhqgie 87 22 the the DT cord-342776-hkjhqgie 87 23 target target NN cord-342776-hkjhqgie 87 24 cells cell NNS cord-342776-hkjhqgie 87 25 ( ( -LRB- cord-342776-hkjhqgie 87 26 32 32 CD cord-342776-hkjhqgie 87 27 ) ) -RRB- cord-342776-hkjhqgie 87 28 . . . cord-342776-hkjhqgie 88 1 Ligands Ligands NNP cord-342776-hkjhqgie 88 2 for for IN cord-342776-hkjhqgie 88 3 NK NK NNP cord-342776-hkjhqgie 88 4 activating activate VBG cord-342776-hkjhqgie 88 5 receptors receptor NNS cord-342776-hkjhqgie 88 6 are be VBP cord-342776-hkjhqgie 88 7 expressed express VBN cord-342776-hkjhqgie 88 8 on on IN cord-342776-hkjhqgie 88 9 fast fast JJ cord-342776-hkjhqgie 88 10 proliferating proliferate VBG cord-342776-hkjhqgie 88 11 cells cell NNS cord-342776-hkjhqgie 88 12 that that WDT cord-342776-hkjhqgie 88 13 are be VBP cord-342776-hkjhqgie 88 14 virally virally RB cord-342776-hkjhqgie 88 15 infected infect VBN cord-342776-hkjhqgie 88 16 or or CC cord-342776-hkjhqgie 88 17 malignantly malignantly RB cord-342776-hkjhqgie 88 18 transformed transform VBN cord-342776-hkjhqgie 88 19 . . . cord-342776-hkjhqgie 89 1 Cytotoxic cytotoxic JJ cord-342776-hkjhqgie 89 2 activity activity NN cord-342776-hkjhqgie 89 3 of of IN cord-342776-hkjhqgie 89 4 NK NK NNP cord-342776-hkjhqgie 89 5 cells cell NNS cord-342776-hkjhqgie 89 6 is be VBZ cord-342776-hkjhqgie 89 7 executed execute VBN cord-342776-hkjhqgie 89 8 by by IN cord-342776-hkjhqgie 89 9 two two CD cord-342776-hkjhqgie 89 10 distinct distinct JJ cord-342776-hkjhqgie 89 11 mechanisms mechanism NNS cord-342776-hkjhqgie 89 12 . . . cord-342776-hkjhqgie 90 1 One one CD cord-342776-hkjhqgie 90 2 is be VBZ cord-342776-hkjhqgie 90 3 regulated regulate VBN cord-342776-hkjhqgie 90 4 by by IN cord-342776-hkjhqgie 90 5 the the DT cord-342776-hkjhqgie 90 6 cytotoxic cytotoxic JJ cord-342776-hkjhqgie 90 7 granules granule NNS cord-342776-hkjhqgie 90 8 containing contain VBG cord-342776-hkjhqgie 90 9 perforin perforin NNP cord-342776-hkjhqgie 90 10 and and CC cord-342776-hkjhqgie 90 11 granzymes granzyme NNS cord-342776-hkjhqgie 90 12 . . . cord-342776-hkjhqgie 91 1 After after IN cord-342776-hkjhqgie 91 2 the the DT cord-342776-hkjhqgie 91 3 formation formation NN cord-342776-hkjhqgie 91 4 of of IN cord-342776-hkjhqgie 91 5 the the DT cord-342776-hkjhqgie 91 6 immune immune JJ cord-342776-hkjhqgie 91 7 synapse synapse NN cord-342776-hkjhqgie 91 8 between between IN cord-342776-hkjhqgie 91 9 NK NK NNP cord-342776-hkjhqgie 91 10 and and CC cord-342776-hkjhqgie 91 11 target target NN cord-342776-hkjhqgie 91 12 cells cell NNS cord-342776-hkjhqgie 91 13 , , , cord-342776-hkjhqgie 91 14 cytotoxic cytotoxic JJ cord-342776-hkjhqgie 91 15 granules granule NNS cord-342776-hkjhqgie 91 16 are be VBP cord-342776-hkjhqgie 91 17 released release VBN cord-342776-hkjhqgie 91 18 . . . cord-342776-hkjhqgie 92 1 Perforin Perforin NNP cord-342776-hkjhqgie 92 2 alters alter VBZ cord-342776-hkjhqgie 92 3 the the DT cord-342776-hkjhqgie 92 4 permeability permeability NN cord-342776-hkjhqgie 92 5 of of IN cord-342776-hkjhqgie 92 6 the the DT cord-342776-hkjhqgie 92 7 target target NN cord-342776-hkjhqgie 92 8 cell cell NN cord-342776-hkjhqgie 92 9 membrane membrane NN cord-342776-hkjhqgie 92 10 , , , cord-342776-hkjhqgie 92 11 allowing allow VBG cord-342776-hkjhqgie 92 12 the the DT cord-342776-hkjhqgie 92 13 entry entry NN cord-342776-hkjhqgie 92 14 of of IN cord-342776-hkjhqgie 92 15 granzymes granzyme NNS cord-342776-hkjhqgie 92 16 . . . cord-342776-hkjhqgie 93 1 The the DT cord-342776-hkjhqgie 93 2 second second JJ cord-342776-hkjhqgie 93 3 pathway pathway NN cord-342776-hkjhqgie 93 4 is be VBZ cord-342776-hkjhqgie 93 5 interaction interaction NN cord-342776-hkjhqgie 93 6 of of IN cord-342776-hkjhqgie 93 7 ligands ligand NNS cord-342776-hkjhqgie 93 8 on on IN cord-342776-hkjhqgie 93 9 NK NK NNP cord-342776-hkjhqgie 93 10 cells cell NNS cord-342776-hkjhqgie 93 11 with with IN cord-342776-hkjhqgie 93 12 their -PRON- PRP$ cord-342776-hkjhqgie 93 13 respective respective JJ cord-342776-hkjhqgie 93 14 cell cell NN cord-342776-hkjhqgie 93 15 death death NN cord-342776-hkjhqgie 93 16 receptors receptor NNS cord-342776-hkjhqgie 93 17 on on IN cord-342776-hkjhqgie 93 18 target target NN cord-342776-hkjhqgie 93 19 cells cell NNS cord-342776-hkjhqgie 93 20 . . . cord-342776-hkjhqgie 94 1 Target target VB cord-342776-hkjhqgie 94 2 cell cell NN cord-342776-hkjhqgie 94 3 death death NN cord-342776-hkjhqgie 94 4 can can MD cord-342776-hkjhqgie 94 5 also also RB cord-342776-hkjhqgie 94 6 be be VB cord-342776-hkjhqgie 94 7 induced induce VBN cord-342776-hkjhqgie 94 8 through through IN cord-342776-hkjhqgie 94 9 antibody antibody NN cord-342776-hkjhqgie 94 10 dependent dependent JJ cord-342776-hkjhqgie 94 11 cellular cellular JJ cord-342776-hkjhqgie 94 12 cytotoxicity cytotoxicity NN cord-342776-hkjhqgie 94 13 ( ( -LRB- cord-342776-hkjhqgie 94 14 ADCC ADCC NNP cord-342776-hkjhqgie 94 15 ) ) -RRB- cord-342776-hkjhqgie 94 16 ( ( -LRB- cord-342776-hkjhqgie 94 17 16 16 CD cord-342776-hkjhqgie 94 18 ) ) -RRB- cord-342776-hkjhqgie 94 19 ( ( -LRB- cord-342776-hkjhqgie 94 20 17 17 CD cord-342776-hkjhqgie 94 21 ) ) -RRB- cord-342776-hkjhqgie 94 22 ( ( -LRB- cord-342776-hkjhqgie 94 23 18 18 CD cord-342776-hkjhqgie 94 24 ) ) -RRB- cord-342776-hkjhqgie 94 25 ( ( -LRB- cord-342776-hkjhqgie 94 26 19 19 CD cord-342776-hkjhqgie 94 27 ) ) -RRB- cord-342776-hkjhqgie 94 28 . . . cord-342776-hkjhqgie 95 1 Indeed indeed RB cord-342776-hkjhqgie 95 2 , , , cord-342776-hkjhqgie 95 3 NK NK NNP cord-342776-hkjhqgie 95 4 cell cell NN cord-342776-hkjhqgie 95 5 mediated mediate VBN cord-342776-hkjhqgie 95 6 ADCC ADCC NNP cord-342776-hkjhqgie 95 7 is be VBZ cord-342776-hkjhqgie 95 8 likely likely JJ cord-342776-hkjhqgie 95 9 one one CD cord-342776-hkjhqgie 95 10 of of IN cord-342776-hkjhqgie 95 11 the the DT cord-342776-hkjhqgie 95 12 key key JJ cord-342776-hkjhqgie 95 13 mechanisms mechanism NNS cord-342776-hkjhqgie 95 14 by by IN cord-342776-hkjhqgie 95 15 which which WDT cord-342776-hkjhqgie 95 16 antibodies antibody NNS cord-342776-hkjhqgie 95 17 induced induce VBN cord-342776-hkjhqgie 95 18 by by IN cord-342776-hkjhqgie 95 19 the the DT cord-342776-hkjhqgie 95 20 virus virus NN cord-342776-hkjhqgie 95 21 in in IN cord-342776-hkjhqgie 95 22 recovered recover VBN cord-342776-hkjhqgie 95 23 patients patient NNS cord-342776-hkjhqgie 95 24 known know VBN cord-342776-hkjhqgie 95 25 as as IN cord-342776-hkjhqgie 95 26 convalescent convalescent JJ cord-342776-hkjhqgie 95 27 plasma plasma NN cord-342776-hkjhqgie 95 28 or or CC cord-342776-hkjhqgie 95 29 serum serum NN cord-342776-hkjhqgie 95 30 are be VBP cord-342776-hkjhqgie 95 31 able able JJ cord-342776-hkjhqgie 95 32 to to TO cord-342776-hkjhqgie 95 33 alleviate alleviate VB cord-342776-hkjhqgie 95 34 the the DT cord-342776-hkjhqgie 95 35 symptoms symptom NNS cord-342776-hkjhqgie 95 36 and and CC cord-342776-hkjhqgie 95 37 improve improve VB cord-342776-hkjhqgie 95 38 the the DT cord-342776-hkjhqgie 95 39 disease disease NN cord-342776-hkjhqgie 95 40 outcomes outcome NNS cord-342776-hkjhqgie 95 41 in in IN cord-342776-hkjhqgie 95 42 infected infected JJ cord-342776-hkjhqgie 95 43 and and CC cord-342776-hkjhqgie 95 44 recovering recover VBG cord-342776-hkjhqgie 95 45 patients patient NNS cord-342776-hkjhqgie 95 46 ( ( -LRB- cord-342776-hkjhqgie 95 47 33 33 CD cord-342776-hkjhqgie 95 48 ) ) -RRB- cord-342776-hkjhqgie 96 1 ( ( -LRB- cord-342776-hkjhqgie 96 2 Figure figure NN cord-342776-hkjhqgie 96 3 1 1 CD cord-342776-hkjhqgie 96 4 ) ) -RRB- cord-342776-hkjhqgie 96 5 . . . cord-342776-hkjhqgie 97 1 The the DT cord-342776-hkjhqgie 97 2 second second JJ cord-342776-hkjhqgie 97 3 key key JJ cord-342776-hkjhqgie 97 4 effector effector NN cord-342776-hkjhqgie 97 5 function function NN cord-342776-hkjhqgie 97 6 of of IN cord-342776-hkjhqgie 97 7 NK NK NNP cord-342776-hkjhqgie 97 8 cells cell NNS cord-342776-hkjhqgie 97 9 is be VBZ cord-342776-hkjhqgie 97 10 the the DT cord-342776-hkjhqgie 97 11 release release NN cord-342776-hkjhqgie 97 12 of of IN cord-342776-hkjhqgie 97 13 cytokines cytokine NNS cord-342776-hkjhqgie 97 14 and and CC cord-342776-hkjhqgie 97 15 chemokines chemokine NNS cord-342776-hkjhqgie 97 16 . . . cord-342776-hkjhqgie 98 1 Two two CD cord-342776-hkjhqgie 98 2 major major JJ cord-342776-hkjhqgie 98 3 cytokines cytokine NNS cord-342776-hkjhqgie 98 4 released release VBN cord-342776-hkjhqgie 98 5 by by IN cord-342776-hkjhqgie 98 6 NK NK NNP cord-342776-hkjhqgie 98 7 cells cell NNS cord-342776-hkjhqgie 98 8 are be VBP cord-342776-hkjhqgie 98 9 IFN IFN NNP cord-342776-hkjhqgie 98 10 - - HYPH cord-342776-hkjhqgie 98 11 γ γ NNP cord-342776-hkjhqgie 98 12 and and CC cord-342776-hkjhqgie 98 13 TNF TNF NNP cord-342776-hkjhqgie 98 14 - - HYPH cord-342776-hkjhqgie 98 15 α α NNP cord-342776-hkjhqgie 98 16 ( ( -LRB- cord-342776-hkjhqgie 98 17 16 16 CD cord-342776-hkjhqgie 98 18 ) ) -RRB- cord-342776-hkjhqgie 98 19 ( ( -LRB- cord-342776-hkjhqgie 98 20 17 17 CD cord-342776-hkjhqgie 98 21 ) ) -RRB- cord-342776-hkjhqgie 98 22 ( ( -LRB- cord-342776-hkjhqgie 98 23 18 18 CD cord-342776-hkjhqgie 98 24 ) ) -RRB- cord-342776-hkjhqgie 98 25 ( ( -LRB- cord-342776-hkjhqgie 98 26 19 19 CD cord-342776-hkjhqgie 98 27 ) ) -RRB- cord-342776-hkjhqgie 98 28 34 34 CD cord-342776-hkjhqgie 98 29 ) ) -RRB- cord-342776-hkjhqgie 98 30 . . . cord-342776-hkjhqgie 99 1 Released release VBN cord-342776-hkjhqgie 99 2 cytokines cytokine NNS cord-342776-hkjhqgie 99 3 not not RB cord-342776-hkjhqgie 99 4 only only RB cord-342776-hkjhqgie 99 5 affect affect VBP cord-342776-hkjhqgie 99 6 the the DT cord-342776-hkjhqgie 99 7 function function NN cord-342776-hkjhqgie 99 8 of of IN cord-342776-hkjhqgie 99 9 innate innate JJ cord-342776-hkjhqgie 99 10 and and CC cord-342776-hkjhqgie 99 11 adaptive adaptive JJ cord-342776-hkjhqgie 99 12 immune immune JJ cord-342776-hkjhqgie 99 13 cells cell NNS cord-342776-hkjhqgie 99 14 , , , cord-342776-hkjhqgie 99 15 but but CC cord-342776-hkjhqgie 99 16 it -PRON- PRP cord-342776-hkjhqgie 99 17 can can MD cord-342776-hkjhqgie 99 18 also also RB cord-342776-hkjhqgie 99 19 impact impact VB cord-342776-hkjhqgie 99 20 the the DT cord-342776-hkjhqgie 99 21 differentiation differentiation NN cord-342776-hkjhqgie 99 22 of of IN cord-342776-hkjhqgie 99 23 both both CC cord-342776-hkjhqgie 99 24 healthy healthy JJ cord-342776-hkjhqgie 99 25 and and CC cord-342776-hkjhqgie 99 26 cancer cancer NN cord-342776-hkjhqgie 99 27 cells cell NNS cord-342776-hkjhqgie 99 28 ( ( -LRB- cord-342776-hkjhqgie 99 29 Figure figure NN cord-342776-hkjhqgie 99 30 1 1 CD cord-342776-hkjhqgie 99 31 ) ) -RRB- cord-342776-hkjhqgie 99 32 . . . cord-342776-hkjhqgie 100 1 Similar similar JJ cord-342776-hkjhqgie 100 2 to to IN cord-342776-hkjhqgie 100 3 SARS SARS NNP cord-342776-hkjhqgie 100 4 - - HYPH cord-342776-hkjhqgie 100 5 CoV-2 CoV-2 NNP cord-342776-hkjhqgie 100 6 infection infection NN cord-342776-hkjhqgie 100 7 in in IN cord-342776-hkjhqgie 100 8 patients patient NNS cord-342776-hkjhqgie 100 9 , , , cord-342776-hkjhqgie 100 10 decreased decrease VBD cord-342776-hkjhqgie 100 11 NK NK NNP cord-342776-hkjhqgie 100 12 cell cell NN cord-342776-hkjhqgie 100 13 function function NN cord-342776-hkjhqgie 100 14 in in IN cord-342776-hkjhqgie 100 15 the the DT cord-342776-hkjhqgie 100 16 tumor tumor NN cord-342776-hkjhqgie 100 17 microenvironment microenvironment NN cord-342776-hkjhqgie 100 18 , , , cord-342776-hkjhqgie 100 19 and and CC cord-342776-hkjhqgie 100 20 peripheral peripheral JJ cord-342776-hkjhqgie 100 21 blood blood NN cord-342776-hkjhqgie 100 22 of of IN cord-342776-hkjhqgie 100 23 cancer cancer NN cord-342776-hkjhqgie 100 24 patients patient NNS cord-342776-hkjhqgie 100 25 as as RB cord-342776-hkjhqgie 100 26 well well RB cord-342776-hkjhqgie 100 27 as as IN cord-342776-hkjhqgie 100 28 down down IN cord-342776-hkjhqgie 100 29 - - HYPH cord-342776-hkjhqgie 100 30 modulation modulation NN cord-342776-hkjhqgie 100 31 of of IN cord-342776-hkjhqgie 100 32 CD16 CD16 NNP cord-342776-hkjhqgie 100 33 receptors receptor NNS cord-342776-hkjhqgie 100 34 on on IN cord-342776-hkjhqgie 100 35 the the DT cord-342776-hkjhqgie 100 36 surface surface NN cord-342776-hkjhqgie 100 37 of of IN cord-342776-hkjhqgie 100 38 NK NK NNP cord-342776-hkjhqgie 100 39 cells cell NNS cord-342776-hkjhqgie 100 40 have have VBP cord-342776-hkjhqgie 100 41 been be VBN cord-342776-hkjhqgie 100 42 reported report VBN cord-342776-hkjhqgie 100 43 previously previously RB cord-342776-hkjhqgie 100 44 ( ( -LRB- cord-342776-hkjhqgie 100 45 23 23 CD cord-342776-hkjhqgie 100 46 , , , cord-342776-hkjhqgie 100 47 ( ( -LRB- cord-342776-hkjhqgie 100 48 35 35 CD cord-342776-hkjhqgie 100 49 ) ) -RRB- cord-342776-hkjhqgie 100 50 ( ( -LRB- cord-342776-hkjhqgie 100 51 36 36 CD cord-342776-hkjhqgie 100 52 ) ) -RRB- cord-342776-hkjhqgie 100 53 ( ( -LRB- cord-342776-hkjhqgie 100 54 37 37 CD cord-342776-hkjhqgie 100 55 ) ) -RRB- cord-342776-hkjhqgie 100 56 ( ( -LRB- cord-342776-hkjhqgie 100 57 38 38 CD cord-342776-hkjhqgie 100 58 ) ) -RRB- cord-342776-hkjhqgie 100 59 ( ( -LRB- cord-342776-hkjhqgie 100 60 39 39 CD cord-342776-hkjhqgie 100 61 ) ) -RRB- cord-342776-hkjhqgie 100 62 ( ( -LRB- cord-342776-hkjhqgie 100 63 40 40 CD cord-342776-hkjhqgie 100 64 ) ) -RRB- cord-342776-hkjhqgie 100 65 . . . cord-342776-hkjhqgie 101 1 Decreased decrease VBN cord-342776-hkjhqgie 102 1 function function NN cord-342776-hkjhqgie 102 2 of of IN cord-342776-hkjhqgie 102 3 NK NK NNP cord-342776-hkjhqgie 102 4 cells cell NNS cord-342776-hkjhqgie 102 5 is be VBZ cord-342776-hkjhqgie 102 6 associated associate VBN cord-342776-hkjhqgie 102 7 with with IN cord-342776-hkjhqgie 102 8 increased increase VBN cord-342776-hkjhqgie 102 9 viral viral JJ cord-342776-hkjhqgie 102 10 infection infection NN cord-342776-hkjhqgie 102 11 and and CC cord-342776-hkjhqgie 102 12 cancer cancer NN cord-342776-hkjhqgie 102 13 risk risk NN cord-342776-hkjhqgie 102 14 , , , cord-342776-hkjhqgie 102 15 whereas whereas IN cord-342776-hkjhqgie 102 16 higher high JJR cord-342776-hkjhqgie 102 17 function function NN cord-342776-hkjhqgie 102 18 was be VBD cord-342776-hkjhqgie 102 19 correlated correlate VBN cord-342776-hkjhqgie 102 20 with with IN cord-342776-hkjhqgie 102 21 prevention prevention NN cord-342776-hkjhqgie 102 22 of of IN cord-342776-hkjhqgie 102 23 establishment establishment NN cord-342776-hkjhqgie 102 24 and and CC cord-342776-hkjhqgie 102 25 progression progression NN cord-342776-hkjhqgie 102 26 of of IN cord-342776-hkjhqgie 102 27 infection infection NN cord-342776-hkjhqgie 102 28 and and CC cord-342776-hkjhqgie 102 29 cancer cancer NN cord-342776-hkjhqgie 102 30 ( ( -LRB- cord-342776-hkjhqgie 102 31 16 16 CD cord-342776-hkjhqgie 102 32 ) ) -RRB- cord-342776-hkjhqgie 102 33 ( ( -LRB- cord-342776-hkjhqgie 102 34 17 17 CD cord-342776-hkjhqgie 102 35 ) ) -RRB- cord-342776-hkjhqgie 102 36 ( ( -LRB- cord-342776-hkjhqgie 102 37 18 18 CD cord-342776-hkjhqgie 102 38 ) ) -RRB- cord-342776-hkjhqgie 102 39 ( ( -LRB- cord-342776-hkjhqgie 102 40 19 19 CD cord-342776-hkjhqgie 102 41 ) ) -RRB- cord-342776-hkjhqgie 102 42 . . . cord-342776-hkjhqgie 103 1 Indeed indeed RB cord-342776-hkjhqgie 103 2 , , , cord-342776-hkjhqgie 103 3 older old JJR cord-342776-hkjhqgie 103 4 patients patient NNS cord-342776-hkjhqgie 103 5 and and CC cord-342776-hkjhqgie 103 6 those those DT cord-342776-hkjhqgie 103 7 with with IN cord-342776-hkjhqgie 103 8 immunosuppression immunosuppression NN cord-342776-hkjhqgie 103 9 are be VBP cord-342776-hkjhqgie 103 10 more more RBR cord-342776-hkjhqgie 103 11 susceptible susceptible JJ cord-342776-hkjhqgie 103 12 to to IN cord-342776-hkjhqgie 103 13 severe severe JJ cord-342776-hkjhqgie 103 14 form form NN cord-342776-hkjhqgie 103 15 of of IN cord-342776-hkjhqgie 103 16 SARS SARS NNP cord-342776-hkjhqgie 103 17 - - HYPH cord-342776-hkjhqgie 103 18 CoV-2 CoV-2 NNP cord-342776-hkjhqgie 103 19 infection infection NN cord-342776-hkjhqgie 103 20 , , , cord-342776-hkjhqgie 103 21 and and CC cord-342776-hkjhqgie 103 22 are be VBP cord-342776-hkjhqgie 103 23 likely likely JJ cord-342776-hkjhqgie 103 24 to to TO cord-342776-hkjhqgie 103 25 die die VB cord-342776-hkjhqgie 103 26 from from IN cord-342776-hkjhqgie 103 27 it -PRON- PRP cord-342776-hkjhqgie 103 28 . . . cord-342776-hkjhqgie 104 1 Thus thus RB cord-342776-hkjhqgie 104 2 , , , cord-342776-hkjhqgie 104 3 it -PRON- PRP cord-342776-hkjhqgie 104 4 is be VBZ cord-342776-hkjhqgie 104 5 no no DT cord-342776-hkjhqgie 104 6 surprise surprise NN cord-342776-hkjhqgie 104 7 that that IN cord-342776-hkjhqgie 104 8 the the DT cord-342776-hkjhqgie 104 9 same same JJ cord-342776-hkjhqgie 104 10 subsets subset NNS cord-342776-hkjhqgie 104 11 of of IN cord-342776-hkjhqgie 104 12 population population NN cord-342776-hkjhqgie 104 13 of of IN cord-342776-hkjhqgie 104 14 individuals individual NNS cord-342776-hkjhqgie 104 15 are be VBP cord-342776-hkjhqgie 104 16 found find VBN cord-342776-hkjhqgie 104 17 to to TO cord-342776-hkjhqgie 104 18 have have VB cord-342776-hkjhqgie 104 19 lower low JJR cord-342776-hkjhqgie 104 20 expansion expansion NN cord-342776-hkjhqgie 104 21 and and CC cord-342776-hkjhqgie 104 22 functions function NNS cord-342776-hkjhqgie 104 23 of of IN cord-342776-hkjhqgie 104 24 NK NK NNP cord-342776-hkjhqgie 104 25 cells cell NNS cord-342776-hkjhqgie 104 26 as as IN cord-342776-hkjhqgie 104 27 reported report VBN cord-342776-hkjhqgie 104 28 previously previously RB cord-342776-hkjhqgie 104 29 ( ( -LRB- cord-342776-hkjhqgie 104 30 41 41 CD cord-342776-hkjhqgie 104 31 , , , cord-342776-hkjhqgie 104 32 42 42 CD cord-342776-hkjhqgie 104 33 ) ) -RRB- cord-342776-hkjhqgie 104 34 . . . cord-342776-hkjhqgie 105 1 Decreased decrease VBD cord-342776-hkjhqgie 105 2 NK NK NNP cord-342776-hkjhqgie 105 3 and and CC cord-342776-hkjhqgie 105 4 T T NNP cord-342776-hkjhqgie 105 5 cell cell NN cord-342776-hkjhqgie 105 6 numbers number NNS cord-342776-hkjhqgie 105 7 and and CC cord-342776-hkjhqgie 105 8 function function NN cord-342776-hkjhqgie 105 9 can can MD cord-342776-hkjhqgie 105 10 be be VB cord-342776-hkjhqgie 105 11 due due JJ cord-342776-hkjhqgie 105 12 to to IN cord-342776-hkjhqgie 105 13 the the DT cord-342776-hkjhqgie 105 14 activation activation NN cord-342776-hkjhqgie 105 15 induced induce VBN cord-342776-hkjhqgie 105 16 cell cell NN cord-342776-hkjhqgie 105 17 death death NN cord-342776-hkjhqgie 105 18 and/or and/or CC cord-342776-hkjhqgie 105 19 direct direct JJ cord-342776-hkjhqgie 105 20 infection infection NN cord-342776-hkjhqgie 105 21 of of IN cord-342776-hkjhqgie 105 22 the the DT cord-342776-hkjhqgie 105 23 immune immune JJ cord-342776-hkjhqgie 105 24 cells cell NNS cord-342776-hkjhqgie 105 25 by by IN cord-342776-hkjhqgie 105 26 the the DT cord-342776-hkjhqgie 105 27 virus virus NN cord-342776-hkjhqgie 105 28 ( ( -LRB- cord-342776-hkjhqgie 105 29 Figure figure NN cord-342776-hkjhqgie 105 30 1 1 CD cord-342776-hkjhqgie 105 31 ) ) -RRB- cord-342776-hkjhqgie 105 32 . . . cord-342776-hkjhqgie 106 1 Indeed indeed RB cord-342776-hkjhqgie 106 2 , , , cord-342776-hkjhqgie 106 3 recent recent JJ cord-342776-hkjhqgie 106 4 studies study NNS cord-342776-hkjhqgie 106 5 indicated indicate VBD cord-342776-hkjhqgie 106 6 that that IN cord-342776-hkjhqgie 106 7 similar similar JJ cord-342776-hkjhqgie 106 8 to to IN cord-342776-hkjhqgie 106 9 MERS MERS NNP cord-342776-hkjhqgie 106 10 - - HYPH cord-342776-hkjhqgie 106 11 CoV cov NN cord-342776-hkjhqgie 106 12 infection infection NN cord-342776-hkjhqgie 106 13 , , , cord-342776-hkjhqgie 106 14 SARS SARS NNP cord-342776-hkjhqgie 106 15 - - HYPH cord-342776-hkjhqgie 106 16 CoV-2 CoV-2 NNP cord-342776-hkjhqgie 106 17 also also RB cord-342776-hkjhqgie 106 18 infects infect VBZ cord-342776-hkjhqgie 106 19 T t NN cord-342776-hkjhqgie 106 20 cells cell NNS cord-342776-hkjhqgie 106 21 through through IN cord-342776-hkjhqgie 106 22 receptor receptor NN cord-342776-hkjhqgie 106 23 - - HYPH cord-342776-hkjhqgie 106 24 dependent dependent JJ cord-342776-hkjhqgie 106 25 , , , cord-342776-hkjhqgie 106 26 S s NN cord-342776-hkjhqgie 106 27 - - HYPH cord-342776-hkjhqgie 106 28 protein protein NN cord-342776-hkjhqgie 106 29 mediated mediate VBD cord-342776-hkjhqgie 106 30 membrane membrane NN cord-342776-hkjhqgie 106 31 fusion fusion NN cord-342776-hkjhqgie 106 32 and and CC cord-342776-hkjhqgie 106 33 that that IN cord-342776-hkjhqgie 106 34 the the DT cord-342776-hkjhqgie 106 35 infection infection NN cord-342776-hkjhqgie 106 36 can can MD cord-342776-hkjhqgie 106 37 be be VB cord-342776-hkjhqgie 106 38 inhibited inhibit VBN cord-342776-hkjhqgie 106 39 by by IN cord-342776-hkjhqgie 106 40 EK1 ek1 NN cord-342776-hkjhqgie 106 41 peptide peptide NN cord-342776-hkjhqgie 106 42 ( ( -LRB- cord-342776-hkjhqgie 106 43 43 43 CD cord-342776-hkjhqgie 106 44 ) ) -RRB- cord-342776-hkjhqgie 106 45 . . . cord-342776-hkjhqgie 107 1 Furthermore furthermore RB cord-342776-hkjhqgie 107 2 , , , cord-342776-hkjhqgie 107 3 the the DT cord-342776-hkjhqgie 107 4 infection infection NN cord-342776-hkjhqgie 107 5 is be VBZ cord-342776-hkjhqgie 107 6 abortive abortive JJ cord-342776-hkjhqgie 107 7 since since IN cord-342776-hkjhqgie 107 8 SARS SARS NNP cord-342776-hkjhqgie 107 9 - - HYPH cord-342776-hkjhqgie 107 10 CoV-2 CoV-2 NNP cord-342776-hkjhqgie 107 11 does do VBZ cord-342776-hkjhqgie 107 12 not not RB cord-342776-hkjhqgie 107 13 have have VB cord-342776-hkjhqgie 107 14 the the DT cord-342776-hkjhqgie 107 15 capability capability NN cord-342776-hkjhqgie 107 16 to to TO cord-342776-hkjhqgie 107 17 replicate replicate VB cord-342776-hkjhqgie 107 18 in in IN cord-342776-hkjhqgie 107 19 the the DT cord-342776-hkjhqgie 107 20 T t NN cord-342776-hkjhqgie 107 21 cells cell NNS cord-342776-hkjhqgie 107 22 ( ( -LRB- cord-342776-hkjhqgie 107 23 43 43 CD cord-342776-hkjhqgie 107 24 ) ) -RRB- cord-342776-hkjhqgie 107 25 . . . cord-342776-hkjhqgie 108 1 With with IN cord-342776-hkjhqgie 108 2 promising promising JJ cord-342776-hkjhqgie 108 3 studies study NNS cord-342776-hkjhqgie 108 4 demonstrating demonstrate VBG cord-342776-hkjhqgie 108 5 significant significant JJ cord-342776-hkjhqgie 108 6 decreases decrease NNS cord-342776-hkjhqgie 108 7 and and CC cord-342776-hkjhqgie 108 8 functional functional JJ cord-342776-hkjhqgie 108 9 deficiencies deficiency NNS cord-342776-hkjhqgie 108 10 in in IN cord-342776-hkjhqgie 108 11 immune immune JJ cord-342776-hkjhqgie 108 12 cell cell NN cord-342776-hkjhqgie 108 13 populations population NNS cord-342776-hkjhqgie 108 14 in in IN cord-342776-hkjhqgie 108 15 particular particular JJ cord-342776-hkjhqgie 108 16 the the DT cord-342776-hkjhqgie 108 17 NK NK NNP cord-342776-hkjhqgie 108 18 cells cell NNS cord-342776-hkjhqgie 108 19 in in IN cord-342776-hkjhqgie 108 20 COVID-19 covid-19 JJ cord-342776-hkjhqgie 108 21 patients patient NNS cord-342776-hkjhqgie 108 22 , , , cord-342776-hkjhqgie 108 23 immunotherapybased immunotherapybased JJ cord-342776-hkjhqgie 108 24 treatments treatment NNS cord-342776-hkjhqgie 108 25 using use VBG cord-342776-hkjhqgie 108 26 NK NK NNP cord-342776-hkjhqgie 108 27 cells cell NNS cord-342776-hkjhqgie 108 28 and and CC cord-342776-hkjhqgie 108 29 CD8 CD8 NNP cord-342776-hkjhqgie 108 30 + + CC cord-342776-hkjhqgie 108 31 T T NNP cord-342776-hkjhqgie 108 32 cells cell NNS cord-342776-hkjhqgie 108 33 and/or and/or CC cord-342776-hkjhqgie 108 34 enhancement enhancement NN cord-342776-hkjhqgie 108 35 of of IN cord-342776-hkjhqgie 108 36 the the DT cord-342776-hkjhqgie 108 37 proliferation proliferation NN cord-342776-hkjhqgie 108 38 and and CC cord-342776-hkjhqgie 108 39 function function NN cord-342776-hkjhqgie 108 40 of of IN cord-342776-hkjhqgie 108 41 NK NK NNP cord-342776-hkjhqgie 108 42 cells cell NNS cord-342776-hkjhqgie 108 43 in in IN cord-342776-hkjhqgie 108 44 patients patient NNS cord-342776-hkjhqgie 108 45 may may MD cord-342776-hkjhqgie 108 46 present present VB cord-342776-hkjhqgie 108 47 a a DT cord-342776-hkjhqgie 108 48 significant significant JJ cord-342776-hkjhqgie 108 49 and and CC cord-342776-hkjhqgie 108 50 viable viable JJ cord-342776-hkjhqgie 108 51 avenue avenue NN cord-342776-hkjhqgie 108 52 toward toward IN cord-342776-hkjhqgie 108 53 mitigating mitigate VBG cord-342776-hkjhqgie 108 54 disease disease NN cord-342776-hkjhqgie 108 55 establishment establishment NN cord-342776-hkjhqgie 108 56 and and CC cord-342776-hkjhqgie 108 57 progression progression NN cord-342776-hkjhqgie 108 58 . . . cord-342776-hkjhqgie 109 1 The the DT cord-342776-hkjhqgie 109 2 original original JJ cord-342776-hkjhqgie 109 3 contributions contribution NNS cord-342776-hkjhqgie 109 4 presented present VBN cord-342776-hkjhqgie 109 5 in in IN cord-342776-hkjhqgie 109 6 the the DT cord-342776-hkjhqgie 109 7 study study NN cord-342776-hkjhqgie 109 8 are be VBP cord-342776-hkjhqgie 109 9 included include VBN cord-342776-hkjhqgie 109 10 in in IN cord-342776-hkjhqgie 109 11 the the DT cord-342776-hkjhqgie 109 12 article article NN cord-342776-hkjhqgie 109 13 / / SYM cord-342776-hkjhqgie 109 14 supplementary supplementary JJ cord-342776-hkjhqgie 109 15 material material NN cord-342776-hkjhqgie 109 16 , , , cord-342776-hkjhqgie 109 17 further further JJ cord-342776-hkjhqgie 109 18 inquiries inquiry NNS cord-342776-hkjhqgie 109 19 can can MD cord-342776-hkjhqgie 109 20 be be VB cord-342776-hkjhqgie 109 21 directed direct VBN cord-342776-hkjhqgie 109 22 to to IN cord-342776-hkjhqgie 109 23 the the DT cord-342776-hkjhqgie 109 24 corresponding correspond VBG cord-342776-hkjhqgie 109 25 author author NN cord-342776-hkjhqgie 109 26 / / SYM cord-342776-hkjhqgie 109 27 s s NN cord-342776-hkjhqgie 109 28 . . . cord-342776-hkjhqgie 110 1 AJ AJ NNP cord-342776-hkjhqgie 110 2 prepared prepare VBD cord-342776-hkjhqgie 110 3 the the DT cord-342776-hkjhqgie 110 4 manuscript manuscript NN cord-342776-hkjhqgie 110 5 . . . cord-342776-hkjhqgie 111 1 Evaluation Evaluation NNP cord-342776-hkjhqgie 111 2 and and CC cord-342776-hkjhqgie 111 3 Treatment Treatment NNP cord-342776-hkjhqgie 111 4 Coronavirus Coronavirus NNP cord-342776-hkjhqgie 111 5 ( ( -LRB- cord-342776-hkjhqgie 111 6 COVID-19 COVID-19 NNP cord-342776-hkjhqgie 111 7 ) ) -RRB- cord-342776-hkjhqgie 111 8 Coronavirus Coronavirus NNP cord-342776-hkjhqgie 111 9 disease disease NN cord-342776-hkjhqgie 111 10 2019 2019 CD cord-342776-hkjhqgie 111 11 : : : cord-342776-hkjhqgie 112 1 what what WP cord-342776-hkjhqgie 112 2 we -PRON- PRP cord-342776-hkjhqgie 112 3 know know VBP cord-342776-hkjhqgie 112 4 Genomic genomic JJ cord-342776-hkjhqgie 112 5 characterisation characterisation NN cord-342776-hkjhqgie 112 6 and and CC cord-342776-hkjhqgie 112 7 epidemiology epidemiology NN cord-342776-hkjhqgie 112 8 of of IN cord-342776-hkjhqgie 112 9 2019 2019 CD cord-342776-hkjhqgie 112 10 novel novel JJ cord-342776-hkjhqgie 112 11 coronavirus coronavirus NN cord-342776-hkjhqgie 112 12 : : : cord-342776-hkjhqgie 113 1 implications implication NNS cord-342776-hkjhqgie 113 2 for for IN cord-342776-hkjhqgie 113 3 virus virus NN cord-342776-hkjhqgie 113 4 origins origin NNS cord-342776-hkjhqgie 113 5 and and CC cord-342776-hkjhqgie 113 6 receptor receptor NN cord-342776-hkjhqgie 113 7 binding bind VBG cord-342776-hkjhqgie 113 8 COVID-19 covid-19 CD cord-342776-hkjhqgie 113 9 : : : cord-342776-hkjhqgie 113 10 what what WP cord-342776-hkjhqgie 113 11 has have VBZ cord-342776-hkjhqgie 113 12 been be VBN cord-342776-hkjhqgie 113 13 learned learn VBN cord-342776-hkjhqgie 113 14 and and CC cord-342776-hkjhqgie 113 15 to to TO cord-342776-hkjhqgie 113 16 be be VB cord-342776-hkjhqgie 113 17 learned learn VBN cord-342776-hkjhqgie 113 18 about about IN cord-342776-hkjhqgie 113 19 the the DT cord-342776-hkjhqgie 113 20 novel novel JJ cord-342776-hkjhqgie 113 21 coronavirus coronavirus NN cord-342776-hkjhqgie 113 22 disease disease NN cord-342776-hkjhqgie 113 23 Preliminary preliminary JJ cord-342776-hkjhqgie 113 24 estimation estimation NN cord-342776-hkjhqgie 113 25 of of IN cord-342776-hkjhqgie 113 26 the the DT cord-342776-hkjhqgie 113 27 basic basic JJ cord-342776-hkjhqgie 113 28 reproduction reproduction NN cord-342776-hkjhqgie 113 29 number number NN cord-342776-hkjhqgie 113 30 of of IN cord-342776-hkjhqgie 113 31 novel novel JJ cord-342776-hkjhqgie 113 32 coronavirus coronavirus NN cord-342776-hkjhqgie 113 33 ( ( -LRB- cord-342776-hkjhqgie 113 34 2019-nCoV 2019-ncov CD cord-342776-hkjhqgie 113 35 ) ) -RRB- cord-342776-hkjhqgie 113 36 in in IN cord-342776-hkjhqgie 113 37 China China NNP cord-342776-hkjhqgie 113 38 , , , cord-342776-hkjhqgie 113 39 from from IN cord-342776-hkjhqgie 113 40 2019 2019 CD cord-342776-hkjhqgie 113 41 to to IN cord-342776-hkjhqgie 113 42 2020 2020 CD cord-342776-hkjhqgie 113 43 : : : cord-342776-hkjhqgie 114 1 a a DT cord-342776-hkjhqgie 114 2 data data NN cord-342776-hkjhqgie 114 3 - - HYPH cord-342776-hkjhqgie 114 4 driven drive VBN cord-342776-hkjhqgie 114 5 analysis analysis NN cord-342776-hkjhqgie 114 6 in in IN cord-342776-hkjhqgie 114 7 the the DT cord-342776-hkjhqgie 114 8 early early JJ cord-342776-hkjhqgie 114 9 phase phase NN cord-342776-hkjhqgie 114 10 of of IN cord-342776-hkjhqgie 114 11 the the DT cord-342776-hkjhqgie 114 12 outbreak outbreak NN cord-342776-hkjhqgie 115 1 Preliminary preliminary JJ cord-342776-hkjhqgie 115 2 estimation estimation NN cord-342776-hkjhqgie 115 3 of of IN cord-342776-hkjhqgie 115 4 the the DT cord-342776-hkjhqgie 115 5 novel novel JJ cord-342776-hkjhqgie 115 6 coronavirus coronavirus NN cord-342776-hkjhqgie 115 7 disease disease NN cord-342776-hkjhqgie 115 8 ( ( -LRB- cord-342776-hkjhqgie 115 9 COVID-19 COVID-19 NNP cord-342776-hkjhqgie 115 10 ) ) -RRB- cord-342776-hkjhqgie 115 11 cases case NNS cord-342776-hkjhqgie 115 12 in in IN cord-342776-hkjhqgie 115 13 Iran Iran NNP cord-342776-hkjhqgie 115 14 : : : cord-342776-hkjhqgie 115 15 A a DT cord-342776-hkjhqgie 115 16 modelling modelling NN cord-342776-hkjhqgie 115 17 analysis analysis NN cord-342776-hkjhqgie 115 18 based base VBN cord-342776-hkjhqgie 115 19 on on IN cord-342776-hkjhqgie 115 20 overseas overseas JJ cord-342776-hkjhqgie 115 21 cases case NNS cord-342776-hkjhqgie 115 22 and and CC cord-342776-hkjhqgie 115 23 air air NN cord-342776-hkjhqgie 115 24 travel travel NN cord-342776-hkjhqgie 115 25 data datum NNS cord-342776-hkjhqgie 115 26 Characteristics characteristic NNS cord-342776-hkjhqgie 115 27 of of IN cord-342776-hkjhqgie 115 28 and and CC cord-342776-hkjhqgie 115 29 important important JJ cord-342776-hkjhqgie 115 30 lessons lesson NNS cord-342776-hkjhqgie 115 31 from from IN cord-342776-hkjhqgie 115 32 the the DT cord-342776-hkjhqgie 115 33 coronavirus coronavirus NN cord-342776-hkjhqgie 115 34 disease disease NN cord-342776-hkjhqgie 115 35 2019 2019 CD cord-342776-hkjhqgie 115 36 ( ( -LRB- cord-342776-hkjhqgie 115 37 COVID-19 COVID-19 NNP cord-342776-hkjhqgie 115 38 ) ) -RRB- cord-342776-hkjhqgie 115 39 outbreak outbreak NN cord-342776-hkjhqgie 115 40 in in IN cord-342776-hkjhqgie 115 41 China China NNP cord-342776-hkjhqgie 115 42 : : : cord-342776-hkjhqgie 115 43 summary summary NN cord-342776-hkjhqgie 115 44 of of IN cord-342776-hkjhqgie 115 45 a a DT cord-342776-hkjhqgie 115 46 report report NN cord-342776-hkjhqgie 115 47 of of IN cord-342776-hkjhqgie 115 48 72314 72314 CD cord-342776-hkjhqgie 115 49 cases case NNS cord-342776-hkjhqgie 115 50 from from IN cord-342776-hkjhqgie 115 51 the the DT cord-342776-hkjhqgie 115 52 Chinese chinese JJ cord-342776-hkjhqgie 115 53 center center NN cord-342776-hkjhqgie 115 54 for for IN cord-342776-hkjhqgie 115 55 disease disease NNP cord-342776-hkjhqgie 115 56 control control NN cord-342776-hkjhqgie 115 57 and and CC cord-342776-hkjhqgie 115 58 prevention prevention NN cord-342776-hkjhqgie 115 59 Serial serial JJ cord-342776-hkjhqgie 115 60 interval interval NN cord-342776-hkjhqgie 115 61 of of IN cord-342776-hkjhqgie 115 62 COVID-19 COVID-19 NNP cord-342776-hkjhqgie 115 63 among among IN cord-342776-hkjhqgie 115 64 publicly publicly RB cord-342776-hkjhqgie 115 65 reported report VBN cord-342776-hkjhqgie 115 66 confirmed confirm VBN cord-342776-hkjhqgie 115 67 cases case NNS cord-342776-hkjhqgie 115 68 Hydroxychloroquine Hydroxychloroquine NNP cord-342776-hkjhqgie 115 69 and and CC cord-342776-hkjhqgie 115 70 azithromycin azithromycin NNP cord-342776-hkjhqgie 115 71 as as IN cord-342776-hkjhqgie 115 72 a a DT cord-342776-hkjhqgie 115 73 treatment treatment NN cord-342776-hkjhqgie 115 74 of of IN cord-342776-hkjhqgie 115 75 COVID-19 covid-19 NN cord-342776-hkjhqgie 115 76 : : : cord-342776-hkjhqgie 115 77 results result NNS cord-342776-hkjhqgie 115 78 of of IN cord-342776-hkjhqgie 115 79 an an DT cord-342776-hkjhqgie 115 80 open open JJ cord-342776-hkjhqgie 115 81 - - HYPH cord-342776-hkjhqgie 115 82 label label NN cord-342776-hkjhqgie 115 83 non non JJ cord-342776-hkjhqgie 115 84 - - JJ cord-342776-hkjhqgie 115 85 randomized randomized JJ cord-342776-hkjhqgie 115 86 clinical clinical JJ cord-342776-hkjhqgie 115 87 trial trial NN cord-342776-hkjhqgie 115 88 Perspectives perspective NNS cord-342776-hkjhqgie 115 89 on on IN cord-342776-hkjhqgie 115 90 monoclonal monoclonal JJ cord-342776-hkjhqgie 115 91 antibody antibody NN cord-342776-hkjhqgie 115 92 therapy therapy NN cord-342776-hkjhqgie 115 93 as as IN cord-342776-hkjhqgie 115 94 potential potential JJ cord-342776-hkjhqgie 115 95 therapeutic therapeutic JJ cord-342776-hkjhqgie 115 96 intervention intervention NN cord-342776-hkjhqgie 115 97 for for IN cord-342776-hkjhqgie 115 98 Coronavirus Coronavirus NNP cord-342776-hkjhqgie 115 99 disease-19 disease-19 , cord-342776-hkjhqgie 115 100 ( ( -LRB- cord-342776-hkjhqgie 115 101 COVID-19 COVID-19 NNP cord-342776-hkjhqgie 115 102 ) ) -RRB- cord-342776-hkjhqgie 115 103 Remdesivir Remdesivir NNP cord-342776-hkjhqgie 115 104 for for IN cord-342776-hkjhqgie 115 105 the the DT cord-342776-hkjhqgie 115 106 Treatment Treatment NNP cord-342776-hkjhqgie 115 107 of of IN cord-342776-hkjhqgie 115 108 Covid-19 Covid-19 NNP cord-342776-hkjhqgie 115 109 -Preliminary -Preliminary NNP cord-342776-hkjhqgie 115 110 Report Report NNP cord-342776-hkjhqgie 115 111 Immune Immune NNP cord-342776-hkjhqgie 115 112 responses response NNS cord-342776-hkjhqgie 115 113 in in IN cord-342776-hkjhqgie 115 114 COVID-19 covid-19 JJ cord-342776-hkjhqgie 115 115 and and CC cord-342776-hkjhqgie 115 116 potential potential JJ cord-342776-hkjhqgie 115 117 vaccines vaccine NNS cord-342776-hkjhqgie 115 118 : : : cord-342776-hkjhqgie 115 119 lessons lesson NNS cord-342776-hkjhqgie 115 120 learned learn VBN cord-342776-hkjhqgie 115 121 from from IN cord-342776-hkjhqgie 115 122 SARS SARS NNP cord-342776-hkjhqgie 115 123 and and CC cord-342776-hkjhqgie 115 124 MERS MERS NNP cord-342776-hkjhqgie 115 125 epidemic epidemic NN cord-342776-hkjhqgie 115 126 Characteristics characteristic NNS cord-342776-hkjhqgie 115 127 of of IN cord-342776-hkjhqgie 115 128 peripheral peripheral JJ cord-342776-hkjhqgie 115 129 lymphocyte lymphocyte NN cord-342776-hkjhqgie 115 130 subset subset VBN cord-342776-hkjhqgie 115 131 alteration alteration NN cord-342776-hkjhqgie 115 132 in in IN cord-342776-hkjhqgie 115 133 COVID-19 COVID-19 NNP cord-342776-hkjhqgie 115 134 pneumonia pneumonia NN cord-342776-hkjhqgie 116 1 The the DT cord-342776-hkjhqgie 116 2 involvement involvement NN cord-342776-hkjhqgie 116 3 of of IN cord-342776-hkjhqgie 116 4 natural natural JJ cord-342776-hkjhqgie 116 5 killer killer NN cord-342776-hkjhqgie 116 6 cells cell NNS cord-342776-hkjhqgie 116 7 in in IN cord-342776-hkjhqgie 116 8 the the DT cord-342776-hkjhqgie 116 9 pathogenesis pathogenesis NN cord-342776-hkjhqgie 116 10 of of IN cord-342776-hkjhqgie 116 11 severe severe JJ cord-342776-hkjhqgie 116 12 acute acute JJ cord-342776-hkjhqgie 116 13 respiratory respiratory JJ cord-342776-hkjhqgie 116 14 syndrome syndrome NN cord-342776-hkjhqgie 116 15 Dysregulation Dysregulation NNP cord-342776-hkjhqgie 116 16 of of IN cord-342776-hkjhqgie 116 17 immune immune JJ cord-342776-hkjhqgie 116 18 response response NN cord-342776-hkjhqgie 116 19 in in IN cord-342776-hkjhqgie 116 20 patients patient NNS cord-342776-hkjhqgie 116 21 with with IN cord-342776-hkjhqgie 116 22 COVID-19 COVID-19 NNP cord-342776-hkjhqgie 116 23 in in IN cord-342776-hkjhqgie 116 24 Wuhan Wuhan NNP cord-342776-hkjhqgie 116 25 , , , cord-342776-hkjhqgie 116 26 China China NNP cord-342776-hkjhqgie 116 27 Editorial Editorial NNP cord-342776-hkjhqgie 116 28 overview overview NN cord-342776-hkjhqgie 116 29 : : : cord-342776-hkjhqgie 116 30 tumour tumour NN cord-342776-hkjhqgie 116 31 immunology immunology NN cord-342776-hkjhqgie 116 32 : : : cord-342776-hkjhqgie 116 33 are be VBP cord-342776-hkjhqgie 116 34 we -PRON- PRP cord-342776-hkjhqgie 116 35 on on IN cord-342776-hkjhqgie 116 36 the the DT cord-342776-hkjhqgie 116 37 path path NN cord-342776-hkjhqgie 116 38 to to TO cord-342776-hkjhqgie 116 39 win win VB cord-342776-hkjhqgie 116 40 the the DT cord-342776-hkjhqgie 116 41 battle battle NN cord-342776-hkjhqgie 116 42 against against IN cord-342776-hkjhqgie 116 43 cancer cancer NN cord-342776-hkjhqgie 116 44 through through IN cord-342776-hkjhqgie 116 45 immunotherapy immunotherapy NN cord-342776-hkjhqgie 116 46 ? ? . cord-342776-hkjhqgie 117 1 NK NK NNP cord-342776-hkjhqgie 117 2 cells cell NNS cord-342776-hkjhqgie 117 3 shape shape VBP cord-342776-hkjhqgie 117 4 pancreatic pancreatic JJ cord-342776-hkjhqgie 117 5 and and CC cord-342776-hkjhqgie 117 6 oral oral JJ cord-342776-hkjhqgie 117 7 tumor tumor NN cord-342776-hkjhqgie 117 8 microenvironments microenvironment NNS cord-342776-hkjhqgie 117 9 ; ; : cord-342776-hkjhqgie 117 10 role role NN cord-342776-hkjhqgie 117 11 in in IN cord-342776-hkjhqgie 117 12 inhibition inhibition NN cord-342776-hkjhqgie 117 13 of of IN cord-342776-hkjhqgie 117 14 tumor tumor NN cord-342776-hkjhqgie 117 15 growth growth NN cord-342776-hkjhqgie 117 16 and and CC cord-342776-hkjhqgie 117 17 metastasis metastasis NN cord-342776-hkjhqgie 117 18 Natural natural JJ cord-342776-hkjhqgie 117 19 killer killer NN cord-342776-hkjhqgie 117 20 cells cell NNS cord-342776-hkjhqgie 117 21 target target VBP cord-342776-hkjhqgie 117 22 and and CC cord-342776-hkjhqgie 117 23 differentiate differentiate VB cord-342776-hkjhqgie 117 24 cancer cancer NN cord-342776-hkjhqgie 117 25 stem stem NN cord-342776-hkjhqgie 117 26 - - HYPH cord-342776-hkjhqgie 117 27 like like JJ cord-342776-hkjhqgie 117 28 cells cell NNS cord-342776-hkjhqgie 117 29 / / SYM cord-342776-hkjhqgie 117 30 undifferentiated undifferentiated JJ cord-342776-hkjhqgie 117 31 tumors tumor NNS cord-342776-hkjhqgie 117 32 : : : cord-342776-hkjhqgie 117 33 strategies strategy NNS cord-342776-hkjhqgie 117 34 to to TO cord-342776-hkjhqgie 117 35 optimize optimize VB cord-342776-hkjhqgie 117 36 their -PRON- PRP$ cord-342776-hkjhqgie 117 37 growth growth NN cord-342776-hkjhqgie 117 38 and and CC cord-342776-hkjhqgie 117 39 expansion expansion NN cord-342776-hkjhqgie 117 40 for for IN cord-342776-hkjhqgie 117 41 effective effective JJ cord-342776-hkjhqgie 117 42 cancer cancer NN cord-342776-hkjhqgie 117 43 immunotherapy immunotherapy NN cord-342776-hkjhqgie 117 44 Natural natural JJ cord-342776-hkjhqgie 117 45 killer killer NN cord-342776-hkjhqgie 117 46 cells cell NNS cord-342776-hkjhqgie 117 47 : : : cord-342776-hkjhqgie 117 48 diverse diverse JJ cord-342776-hkjhqgie 117 49 functions function NNS cord-342776-hkjhqgie 117 50 in in IN cord-342776-hkjhqgie 117 51 tumor tumor NN cord-342776-hkjhqgie 117 52 immunity immunity NN cord-342776-hkjhqgie 117 53 and and CC cord-342776-hkjhqgie 117 54 defects defect NNS cord-342776-hkjhqgie 117 55 in in IN cord-342776-hkjhqgie 117 56 pre pre JJ cord-342776-hkjhqgie 117 57 - - JJ cord-342776-hkjhqgie 117 58 neoplastic neoplastic JJ cord-342776-hkjhqgie 117 59 and and CC cord-342776-hkjhqgie 117 60 neoplastic neoplastic JJ cord-342776-hkjhqgie 117 61 stages stage NNS cord-342776-hkjhqgie 117 62 of of IN cord-342776-hkjhqgie 117 63 tumorigenesis tumorigenesis NN cord-342776-hkjhqgie 117 64 Functional functional JJ cord-342776-hkjhqgie 117 65 exhaustion exhaustion NN cord-342776-hkjhqgie 117 66 of of IN cord-342776-hkjhqgie 117 67 antiviral antiviral JJ cord-342776-hkjhqgie 117 68 lymphocytes lymphocyte NNS cord-342776-hkjhqgie 117 69 in in IN cord-342776-hkjhqgie 117 70 COVID-19 covid-19 CD cord-342776-hkjhqgie 117 71 patients patient NNS cord-342776-hkjhqgie 118 1 Pulmonary pulmonary JJ cord-342776-hkjhqgie 118 2 natural natural JJ cord-342776-hkjhqgie 118 3 killer killer NN cord-342776-hkjhqgie 118 4 cells cell NNS cord-342776-hkjhqgie 118 5 control control VBP cord-342776-hkjhqgie 118 6 neutrophil neutrophil NN cord-342776-hkjhqgie 118 7 intravascular intravascular JJ cord-342776-hkjhqgie 118 8 motility motility NN cord-342776-hkjhqgie 118 9 and and CC cord-342776-hkjhqgie 118 10 response response NN cord-342776-hkjhqgie 118 11 to to IN cord-342776-hkjhqgie 118 12 acute acute JJ cord-342776-hkjhqgie 118 13 inflammation inflammation NN cord-342776-hkjhqgie 119 1 Lung lung NN cord-342776-hkjhqgie 119 2 natural natural JJ cord-342776-hkjhqgie 119 3 killer killer NN cord-342776-hkjhqgie 119 4 cells cell NNS cord-342776-hkjhqgie 119 5 play play VBP cord-342776-hkjhqgie 119 6 a a DT cord-342776-hkjhqgie 119 7 major major JJ cord-342776-hkjhqgie 119 8 counter counter JJ cord-342776-hkjhqgie 119 9 - - JJ cord-342776-hkjhqgie 119 10 regulatory regulatory JJ cord-342776-hkjhqgie 119 11 role role NN cord-342776-hkjhqgie 119 12 in in IN cord-342776-hkjhqgie 119 13 pulmonary pulmonary JJ cord-342776-hkjhqgie 119 14 vascular vascular JJ cord-342776-hkjhqgie 119 15 hyperpermeability hyperpermeability NN cord-342776-hkjhqgie 119 16 after after IN cord-342776-hkjhqgie 119 17 myocardial myocardial JJ cord-342776-hkjhqgie 119 18 infarction infarction NNP cord-342776-hkjhqgie 119 19 Super Super NNP cord-342776-hkjhqgie 119 20 - - NNP cord-342776-hkjhqgie 119 21 charged charge VBN cord-342776-hkjhqgie 119 22 NK NK NNP cord-342776-hkjhqgie 119 23 cells cell NNS cord-342776-hkjhqgie 119 24 inhibit inhibit VBP cord-342776-hkjhqgie 119 25 growth growth NN cord-342776-hkjhqgie 119 26 and and CC cord-342776-hkjhqgie 119 27 progression progression NN cord-342776-hkjhqgie 119 28 of of IN cord-342776-hkjhqgie 119 29 stem stem NN cord-342776-hkjhqgie 119 30 - - HYPH cord-342776-hkjhqgie 119 31 like like JJ cord-342776-hkjhqgie 119 32 / / , cord-342776-hkjhqgie 119 33 poorly poorly RB cord-342776-hkjhqgie 119 34 differentiated differentiate VBN cord-342776-hkjhqgie 119 35 oral oral JJ cord-342776-hkjhqgie 119 36 tumors tumor NNS cord-342776-hkjhqgie 119 37 in in IN cord-342776-hkjhqgie 119 38 vivo vivo NN cord-342776-hkjhqgie 119 39 in in IN cord-342776-hkjhqgie 119 40 humanized humanize VBN cord-342776-hkjhqgie 119 41 BLT BLT NNP cord-342776-hkjhqgie 119 42 mice mouse NNS cord-342776-hkjhqgie 119 43 ; ; : cord-342776-hkjhqgie 119 44 effect effect NN cord-342776-hkjhqgie 119 45 on on IN cord-342776-hkjhqgie 119 46 tumor tumor NN cord-342776-hkjhqgie 119 47 differentiation differentiation NN cord-342776-hkjhqgie 119 48 and and CC cord-342776-hkjhqgie 119 49 response response NN cord-342776-hkjhqgie 119 50 to to IN cord-342776-hkjhqgie 119 51 chemotherapeutic chemotherapeutic JJ cord-342776-hkjhqgie 119 52 drugs drug NNS cord-342776-hkjhqgie 119 53 Probiotic Probiotic NNP cord-342776-hkjhqgie 119 54 - - HYPH cord-342776-hkjhqgie 119 55 treated treat VBN cord-342776-hkjhqgie 119 56 super super RB cord-342776-hkjhqgie 119 57 - - HYPH cord-342776-hkjhqgie 119 58 charged charge VBN cord-342776-hkjhqgie 119 59 NK NK NNP cord-342776-hkjhqgie 119 60 cells cell NNS cord-342776-hkjhqgie 119 61 efficiently efficiently RB cord-342776-hkjhqgie 119 62 clear clear JJ cord-342776-hkjhqgie 119 63 poorly poorly RB cord-342776-hkjhqgie 119 64 differentiated differentiate VBN cord-342776-hkjhqgie 119 65 pancreatic pancreatic JJ cord-342776-hkjhqgie 119 66 tumors tumor NNS cord-342776-hkjhqgie 119 67 in in IN cord-342776-hkjhqgie 119 68 Hu Hu NNP cord-342776-hkjhqgie 119 69 - - HYPH cord-342776-hkjhqgie 119 70 BLT BLT NNP cord-342776-hkjhqgie 119 71 Mice Mice NNP cord-342776-hkjhqgie 119 72 Association Association NNP cord-342776-hkjhqgie 119 73 of of IN cord-342776-hkjhqgie 119 74 coronavirus coronavirus NN cord-342776-hkjhqgie 119 75 disease disease NNP cord-342776-hkjhqgie 119 76 2019 2019 CD cord-342776-hkjhqgie 119 77 ( ( -LRB- cord-342776-hkjhqgie 119 78 COVID-19 covid-19 VB cord-342776-hkjhqgie 119 79 ) ) -RRB- cord-342776-hkjhqgie 119 80 with with IN cord-342776-hkjhqgie 119 81 myocardial myocardial JJ cord-342776-hkjhqgie 119 82 injury injury NN cord-342776-hkjhqgie 119 83 and and CC cord-342776-hkjhqgie 119 84 mortality mortality NN cord-342776-hkjhqgie 120 1 The the DT cord-342776-hkjhqgie 120 2 role role NN cord-342776-hkjhqgie 120 3 of of IN cord-342776-hkjhqgie 120 4 cytokines cytokine NNS cord-342776-hkjhqgie 120 5 including include VBG cord-342776-hkjhqgie 120 6 interleukin-6 interleukin-6 NNP cord-342776-hkjhqgie 120 7 in in IN cord-342776-hkjhqgie 120 8 COVID-19 COVID-19 NNP cord-342776-hkjhqgie 120 9 induced induce VBN cord-342776-hkjhqgie 120 10 pneumonia pneumonia NN cord-342776-hkjhqgie 120 11 and and CC cord-342776-hkjhqgie 120 12 macrophage macrophage NN cord-342776-hkjhqgie 120 13 activation activation NN cord-342776-hkjhqgie 120 14 syndrome syndrome NN cord-342776-hkjhqgie 120 15 - - HYPH cord-342776-hkjhqgie 120 16 like like JJ cord-342776-hkjhqgie 120 17 disease disease NN cord-342776-hkjhqgie 120 18 Cytokine cytokine NN cord-342776-hkjhqgie 120 19 release release NN cord-342776-hkjhqgie 120 20 syndrome syndrome NN cord-342776-hkjhqgie 120 21 in in IN cord-342776-hkjhqgie 120 22 severe severe JJ cord-342776-hkjhqgie 120 23 COVID-19 COVID-19 NNP cord-342776-hkjhqgie 120 24 NK NK NNP cord-342776-hkjhqgie 120 25 cell cell NN cord-342776-hkjhqgie 120 26 - - HYPH cord-342776-hkjhqgie 120 27 based base VBN cord-342776-hkjhqgie 120 28 immunotherapy immunotherapy NN cord-342776-hkjhqgie 120 29 for for IN cord-342776-hkjhqgie 120 30 cancer cancer NN cord-342776-hkjhqgie 121 1 The the DT cord-342776-hkjhqgie 121 2 broad broad JJ cord-342776-hkjhqgie 121 3 spectrum spectrum NN cord-342776-hkjhqgie 121 4 of of IN cord-342776-hkjhqgie 121 5 human human JJ cord-342776-hkjhqgie 121 6 natural natural JJ cord-342776-hkjhqgie 121 7 killer killer NN cord-342776-hkjhqgie 121 8 cell cell NN cord-342776-hkjhqgie 121 9 diversity diversity NN cord-342776-hkjhqgie 122 1 The the DT cord-342776-hkjhqgie 122 2 biology biology NN cord-342776-hkjhqgie 122 3 of of IN cord-342776-hkjhqgie 122 4 human human JJ cord-342776-hkjhqgie 122 5 natural natural JJ cord-342776-hkjhqgie 122 6 killer killer NN cord-342776-hkjhqgie 122 7 - - HYPH cord-342776-hkjhqgie 122 8 cell cell NN cord-342776-hkjhqgie 122 9 subsets subset NNS cord-342776-hkjhqgie 122 10 Natural natural JJ cord-342776-hkjhqgie 122 11 killer killer NN cord-342776-hkjhqgie 122 12 cell cell NN cord-342776-hkjhqgie 122 13 distribution distribution NN cord-342776-hkjhqgie 122 14 and and CC cord-342776-hkjhqgie 122 15 trafficking trafficking NN cord-342776-hkjhqgie 122 16 in in IN cord-342776-hkjhqgie 122 17 human human JJ cord-342776-hkjhqgie 122 18 tissues tissue NNS cord-342776-hkjhqgie 123 1 Activating activate VBG cord-342776-hkjhqgie 123 2 and and CC cord-342776-hkjhqgie 123 3 inhibitory inhibitory JJ cord-342776-hkjhqgie 123 4 receptors receptor NNS cord-342776-hkjhqgie 123 5 of of IN cord-342776-hkjhqgie 123 6 natural natural JJ cord-342776-hkjhqgie 123 7 killer killer NN cord-342776-hkjhqgie 123 8 cells cell NNS cord-342776-hkjhqgie 123 9 Treatment treatment NN cord-342776-hkjhqgie 123 10 of of IN cord-342776-hkjhqgie 123 11 5 5 CD cord-342776-hkjhqgie 123 12 critically critically RB cord-342776-hkjhqgie 123 13 Ill ill JJ cord-342776-hkjhqgie 123 14 patients patient NNS cord-342776-hkjhqgie 123 15 with with IN cord-342776-hkjhqgie 123 16 COVID-19 COVID-19 NNP cord-342776-hkjhqgie 123 17 with with IN cord-342776-hkjhqgie 123 18 convalescent convalescent JJ cord-342776-hkjhqgie 123 19 plasma plasma NN cord-342776-hkjhqgie 123 20 Natural natural JJ cord-342776-hkjhqgie 123 21 killer killer NN cord-342776-hkjhqgie 123 22 cells cell NNS cord-342776-hkjhqgie 123 23 : : : cord-342776-hkjhqgie 123 24 development development NN cord-342776-hkjhqgie 123 25 , , , cord-342776-hkjhqgie 123 26 maturation maturation NN cord-342776-hkjhqgie 123 27 , , , cord-342776-hkjhqgie 123 28 and and CC cord-342776-hkjhqgie 123 29 clinical clinical JJ cord-342776-hkjhqgie 123 30 utilization utilization NN cord-342776-hkjhqgie 123 31 Alterations alteration NNS cord-342776-hkjhqgie 123 32 in in IN cord-342776-hkjhqgie 123 33 expression expression NN cord-342776-hkjhqgie 123 34 and and CC cord-342776-hkjhqgie 123 35 function function NN cord-342776-hkjhqgie 123 36 of of IN cord-342776-hkjhqgie 123 37 signal signal NN cord-342776-hkjhqgie 123 38 - - HYPH cord-342776-hkjhqgie 123 39 transducing transduce VBG cord-342776-hkjhqgie 123 40 proteins protein NNS cord-342776-hkjhqgie 123 41 in in IN cord-342776-hkjhqgie 123 42 tumor tumor NN cord-342776-hkjhqgie 123 43 - - HYPH cord-342776-hkjhqgie 123 44 associated associate VBN cord-342776-hkjhqgie 123 45 T T NNP cord-342776-hkjhqgie 123 46 and and CC cord-342776-hkjhqgie 123 47 natural natural JJ cord-342776-hkjhqgie 123 48 killer killer NN cord-342776-hkjhqgie 123 49 cells cell NNS cord-342776-hkjhqgie 123 50 in in IN cord-342776-hkjhqgie 123 51 patients patient NNS cord-342776-hkjhqgie 123 52 with with IN cord-342776-hkjhqgie 123 53 ovarian ovarian JJ cord-342776-hkjhqgie 123 54 carcinoma carcinoma NN cord-342776-hkjhqgie 123 55 Clinical clinical JJ cord-342776-hkjhqgie 123 56 significance significance NN cord-342776-hkjhqgie 123 57 of of IN cord-342776-hkjhqgie 123 58 decreased decrease VBN cord-342776-hkjhqgie 123 59 zeta zeta NNP cord-342776-hkjhqgie 123 60 chain chain NN cord-342776-hkjhqgie 123 61 expression expression NN cord-342776-hkjhqgie 123 62 in in IN cord-342776-hkjhqgie 123 63 peripheral peripheral JJ cord-342776-hkjhqgie 123 64 blood blood NN cord-342776-hkjhqgie 123 65 lymphocytes lymphocyte NNS cord-342776-hkjhqgie 123 66 of of IN cord-342776-hkjhqgie 123 67 patients patient NNS cord-342776-hkjhqgie 123 68 with with IN cord-342776-hkjhqgie 123 69 head head NN cord-342776-hkjhqgie 123 70 and and CC cord-342776-hkjhqgie 123 71 neck neck NN cord-342776-hkjhqgie 123 72 cancer cancer NN cord-342776-hkjhqgie 123 73 Natural natural JJ cord-342776-hkjhqgie 123 74 cytotoxic cytotoxic JJ cord-342776-hkjhqgie 123 75 activity activity NN cord-342776-hkjhqgie 123 76 of of IN cord-342776-hkjhqgie 123 77 peripheral peripheral JJ cord-342776-hkjhqgie 123 78 - - HYPH cord-342776-hkjhqgie 123 79 blood blood NN cord-342776-hkjhqgie 123 80 lymphocytes lymphocyte NNS cord-342776-hkjhqgie 123 81 and and CC cord-342776-hkjhqgie 123 82 cancer cancer NN cord-342776-hkjhqgie 123 83 incidence incidence NN cord-342776-hkjhqgie 123 84 : : : cord-342776-hkjhqgie 123 85 an an DT cord-342776-hkjhqgie 123 86 11-year 11-year JJ cord-342776-hkjhqgie 123 87 follow follow NN cord-342776-hkjhqgie 123 88 - - HYPH cord-342776-hkjhqgie 123 89 up up NN cord-342776-hkjhqgie 123 90 study study NN cord-342776-hkjhqgie 123 91 of of IN cord-342776-hkjhqgie 123 92 a a DT cord-342776-hkjhqgie 123 93 general general JJ cord-342776-hkjhqgie 123 94 population population NN cord-342776-hkjhqgie 123 95 Progressive progressive JJ cord-342776-hkjhqgie 123 96 natural natural JJ cord-342776-hkjhqgie 123 97 killer killer NN cord-342776-hkjhqgie 123 98 cell cell NN cord-342776-hkjhqgie 123 99 dysfunction dysfunction NN cord-342776-hkjhqgie 123 100 associated associate VBN cord-342776-hkjhqgie 123 101 with with IN cord-342776-hkjhqgie 123 102 alterations alteration NNS cord-342776-hkjhqgie 123 103 in in IN cord-342776-hkjhqgie 123 104 subset subset JJ cord-342776-hkjhqgie 123 105 proportions proportion NNS cord-342776-hkjhqgie 123 106 and and CC cord-342776-hkjhqgie 123 107 receptor receptor NN cord-342776-hkjhqgie 123 108 expression expression NN cord-342776-hkjhqgie 123 109 in in IN cord-342776-hkjhqgie 123 110 soft soft JJ cord-342776-hkjhqgie 123 111 - - HYPH cord-342776-hkjhqgie 123 112 tissue tissue NN cord-342776-hkjhqgie 123 113 sarcoma sarcoma NN cord-342776-hkjhqgie 123 114 patients patient NNS cord-342776-hkjhqgie 124 1 Novel novel JJ cord-342776-hkjhqgie 124 2 strategy strategy NN cord-342776-hkjhqgie 124 3 to to TO cord-342776-hkjhqgie 124 4 expand expand VB cord-342776-hkjhqgie 124 5 super super RB cord-342776-hkjhqgie 124 6 - - JJ cord-342776-hkjhqgie 124 7 charged charge VBN cord-342776-hkjhqgie 124 8 NK NK NNP cord-342776-hkjhqgie 124 9 cells cell NNS cord-342776-hkjhqgie 124 10 with with IN cord-342776-hkjhqgie 124 11 significant significant JJ cord-342776-hkjhqgie 124 12 potential potential NN cord-342776-hkjhqgie 124 13 to to TO cord-342776-hkjhqgie 124 14 lyse lyse VB cord-342776-hkjhqgie 124 15 and and CC cord-342776-hkjhqgie 124 16 differentiate differentiate VB cord-342776-hkjhqgie 124 17 cancer cancer NN cord-342776-hkjhqgie 124 18 stem stem NN cord-342776-hkjhqgie 124 19 cells cell NNS cord-342776-hkjhqgie 124 20 : : : cord-342776-hkjhqgie 124 21 differences difference NNS cord-342776-hkjhqgie 124 22 in in IN cord-342776-hkjhqgie 124 23 NK NK NNP cord-342776-hkjhqgie 124 24 expansion expansion NN cord-342776-hkjhqgie 124 25 and and CC cord-342776-hkjhqgie 124 26 function function VB cord-342776-hkjhqgie 124 27 between between IN cord-342776-hkjhqgie 124 28 healthy healthy JJ cord-342776-hkjhqgie 124 29 and and CC cord-342776-hkjhqgie 124 30 cancer cancer NN cord-342776-hkjhqgie 124 31 patients patient NNS cord-342776-hkjhqgie 124 32 Deficiencies deficiency NNS cord-342776-hkjhqgie 124 33 in in IN cord-342776-hkjhqgie 124 34 natural natural JJ cord-342776-hkjhqgie 124 35 killer killer NN cord-342776-hkjhqgie 124 36 cell cell NN cord-342776-hkjhqgie 124 37 numbers number NNS cord-342776-hkjhqgie 124 38 , , , cord-342776-hkjhqgie 124 39 expansion expansion NN cord-342776-hkjhqgie 124 40 , , , cord-342776-hkjhqgie 124 41 and and CC cord-342776-hkjhqgie 124 42 function function VB cord-342776-hkjhqgie 124 43 at at IN cord-342776-hkjhqgie 124 44 the the DT cord-342776-hkjhqgie 124 45 preneoplastic preneoplastic JJ cord-342776-hkjhqgie 124 46 stage stage NN cord-342776-hkjhqgie 124 47 of of IN cord-342776-hkjhqgie 124 48 pancreatic pancreatic JJ cord-342776-hkjhqgie 124 49 cancer cancer NN cord-342776-hkjhqgie 124 50 by by IN cord-342776-hkjhqgie 124 51 KRAS KRAS NNP cord-342776-hkjhqgie 124 52 mutation mutation NN cord-342776-hkjhqgie 124 53 in in IN cord-342776-hkjhqgie 124 54 the the DT cord-342776-hkjhqgie 124 55 pancreas pancreas NN cord-342776-hkjhqgie 124 56 of of IN cord-342776-hkjhqgie 124 57 obese obese JJ cord-342776-hkjhqgie 124 58 mice mouse NNS cord-342776-hkjhqgie 125 1 The the DT cord-342776-hkjhqgie 125 2 impact impact NN cord-342776-hkjhqgie 125 3 of of IN cord-342776-hkjhqgie 125 4 ageing age VBG cord-342776-hkjhqgie 125 5 on on IN cord-342776-hkjhqgie 125 6 natural natural JJ cord-342776-hkjhqgie 125 7 killer killer NN cord-342776-hkjhqgie 125 8 cell cell NN cord-342776-hkjhqgie 125 9 function function NN cord-342776-hkjhqgie 125 10 and and CC cord-342776-hkjhqgie 125 11 potential potential JJ cord-342776-hkjhqgie 125 12 consequences consequence NNS cord-342776-hkjhqgie 125 13 for for IN cord-342776-hkjhqgie 125 14 health health NN cord-342776-hkjhqgie 125 15 in in IN cord-342776-hkjhqgie 125 16 older old JJR cord-342776-hkjhqgie 125 17 adults adult NNS cord-342776-hkjhqgie 126 1 Effect effect NN cord-342776-hkjhqgie 126 2 of of IN cord-342776-hkjhqgie 126 3 aging age VBG cord-342776-hkjhqgie 126 4 on on IN cord-342776-hkjhqgie 126 5 NK NK NNP cord-342776-hkjhqgie 126 6 cell cell NN cord-342776-hkjhqgie 126 7 population population NN cord-342776-hkjhqgie 126 8 and and CC cord-342776-hkjhqgie 126 9 their -PRON- PRP$ cord-342776-hkjhqgie 126 10 Proliferation proliferation NN cord-342776-hkjhqgie 126 11 at at IN cord-342776-hkjhqgie 127 1 ex ex FW cord-342776-hkjhqgie 127 2 vivo vivo NN cord-342776-hkjhqgie 127 3 culture culture NN cord-342776-hkjhqgie 127 4 condition condition NN cord-342776-hkjhqgie 127 5 RETRACTED retract VBN cord-342776-hkjhqgie 127 6 ARTICLE article NN cord-342776-hkjhqgie 127 7 : : : cord-342776-hkjhqgie 128 1 SARS SARS NNP cord-342776-hkjhqgie 128 2 - - HYPH cord-342776-hkjhqgie 128 3 CoV-2 CoV-2 NNP cord-342776-hkjhqgie 128 4 infects infect VBZ cord-342776-hkjhqgie 128 5 T t NN cord-342776-hkjhqgie 128 6 lymphocytes lymphocyte NNS cord-342776-hkjhqgie 128 7 through through IN cord-342776-hkjhqgie 128 8 its -PRON- PRP$ cord-342776-hkjhqgie 128 9 spike spike NN cord-342776-hkjhqgie 128 10 protein protein NN cord-342776-hkjhqgie 128 11 - - HYPH cord-342776-hkjhqgie 128 12 mediated mediate VBN cord-342776-hkjhqgie 128 13 membrane membrane NN cord-342776-hkjhqgie 128 14 fusion fusion NN cord-342776-hkjhqgie 129 1 The the DT cord-342776-hkjhqgie 129 2 author author NN cord-342776-hkjhqgie 129 3 declares declare VBZ cord-342776-hkjhqgie 129 4 that that IN cord-342776-hkjhqgie 129 5 the the DT cord-342776-hkjhqgie 129 6 research research NN cord-342776-hkjhqgie 129 7 was be VBD cord-342776-hkjhqgie 129 8 conducted conduct VBN cord-342776-hkjhqgie 129 9 in in IN cord-342776-hkjhqgie 129 10 the the DT cord-342776-hkjhqgie 129 11 absence absence NN cord-342776-hkjhqgie 129 12 of of IN cord-342776-hkjhqgie 129 13 any any DT cord-342776-hkjhqgie 129 14 commercial commercial JJ cord-342776-hkjhqgie 129 15 or or CC cord-342776-hkjhqgie 129 16 financial financial JJ cord-342776-hkjhqgie 129 17 relationships relationship NNS cord-342776-hkjhqgie 129 18 that that WDT cord-342776-hkjhqgie 129 19 could could MD cord-342776-hkjhqgie 129 20 be be VB cord-342776-hkjhqgie 129 21 construed construe VBN cord-342776-hkjhqgie 129 22 as as IN cord-342776-hkjhqgie 129 23 a a DT cord-342776-hkjhqgie 129 24 potential potential JJ cord-342776-hkjhqgie 129 25 conflict conflict NN cord-342776-hkjhqgie 129 26 of of IN cord-342776-hkjhqgie 129 27 interest interest NN cord-342776-hkjhqgie 129 28 . . . cord-342776-hkjhqgie 130 1 Copyright copyright NN cord-342776-hkjhqgie 130 2 © © NNP cord-342776-hkjhqgie 130 3 2020 2020 CD cord-342776-hkjhqgie 130 4 Jewett Jewett NNP cord-342776-hkjhqgie 130 5 . . . cord-342776-hkjhqgie 131 1 This this DT cord-342776-hkjhqgie 131 2 is be VBZ cord-342776-hkjhqgie 131 3 an an DT cord-342776-hkjhqgie 131 4 open open JJ cord-342776-hkjhqgie 131 5 - - HYPH cord-342776-hkjhqgie 131 6 access access NN cord-342776-hkjhqgie 131 7 article article NN cord-342776-hkjhqgie 131 8 distributed distribute VBN cord-342776-hkjhqgie 131 9 under under IN cord-342776-hkjhqgie 131 10 the the DT cord-342776-hkjhqgie 131 11 terms term NNS cord-342776-hkjhqgie 131 12 of of IN cord-342776-hkjhqgie 131 13 the the DT cord-342776-hkjhqgie 131 14 Creative Creative NNP cord-342776-hkjhqgie 131 15 Commons Commons NNP cord-342776-hkjhqgie 131 16 Attribution Attribution NNP cord-342776-hkjhqgie 131 17 License License NNP cord-342776-hkjhqgie 131 18 ( ( -LRB- cord-342776-hkjhqgie 131 19 CC CC NNP cord-342776-hkjhqgie 131 20 BY BY NNP cord-342776-hkjhqgie 131 21 ) ) -RRB- cord-342776-hkjhqgie 131 22 . . . cord-342776-hkjhqgie 132 1 The the DT cord-342776-hkjhqgie 132 2 use use NN cord-342776-hkjhqgie 132 3 , , , cord-342776-hkjhqgie 132 4 distribution distribution NN cord-342776-hkjhqgie 132 5 or or CC cord-342776-hkjhqgie 132 6 reproduction reproduction NN cord-342776-hkjhqgie 132 7 in in IN cord-342776-hkjhqgie 132 8 other other JJ cord-342776-hkjhqgie 132 9 forums forum NNS cord-342776-hkjhqgie 132 10 is be VBZ cord-342776-hkjhqgie 132 11 permitted permit VBN cord-342776-hkjhqgie 132 12 , , , cord-342776-hkjhqgie 132 13 provided provide VBD cord-342776-hkjhqgie 132 14 the the DT cord-342776-hkjhqgie 132 15 original original JJ cord-342776-hkjhqgie 132 16 author(s author(s NNP cord-342776-hkjhqgie 132 17 ) ) -RRB- cord-342776-hkjhqgie 132 18 and and CC cord-342776-hkjhqgie 132 19 the the DT cord-342776-hkjhqgie 132 20 copyright copyright NN cord-342776-hkjhqgie 132 21 owner(s owner(s NNP cord-342776-hkjhqgie 132 22 ) ) -RRB- cord-342776-hkjhqgie 132 23 are be VBP cord-342776-hkjhqgie 132 24 credited credit VBN cord-342776-hkjhqgie 132 25 and and CC cord-342776-hkjhqgie 132 26 that that IN cord-342776-hkjhqgie 132 27 the the DT cord-342776-hkjhqgie 132 28 original original JJ cord-342776-hkjhqgie 132 29 publication publication NN cord-342776-hkjhqgie 132 30 in in IN cord-342776-hkjhqgie 132 31 this this DT cord-342776-hkjhqgie 132 32 journal journal NN cord-342776-hkjhqgie 132 33 is be VBZ cord-342776-hkjhqgie 132 34 cited cite VBN cord-342776-hkjhqgie 132 35 , , , cord-342776-hkjhqgie 132 36 in in IN cord-342776-hkjhqgie 132 37 accordance accordance NN cord-342776-hkjhqgie 132 38 with with IN cord-342776-hkjhqgie 132 39 accepted accepted JJ cord-342776-hkjhqgie 132 40 academic academic JJ cord-342776-hkjhqgie 132 41 practice practice NN cord-342776-hkjhqgie 132 42 . . . cord-342776-hkjhqgie 133 1 No no DT cord-342776-hkjhqgie 133 2 use use NN cord-342776-hkjhqgie 133 3 , , , cord-342776-hkjhqgie 133 4 distribution distribution NN cord-342776-hkjhqgie 133 5 or or CC cord-342776-hkjhqgie 133 6 reproduction reproduction NN cord-342776-hkjhqgie 133 7 is be VBZ cord-342776-hkjhqgie 133 8 permitted permit VBN cord-342776-hkjhqgie 133 9 which which WDT cord-342776-hkjhqgie 133 10 does do VBZ cord-342776-hkjhqgie 133 11 not not RB cord-342776-hkjhqgie 133 12 comply comply VB cord-342776-hkjhqgie 133 13 with with IN cord-342776-hkjhqgie 133 14 these these DT cord-342776-hkjhqgie 133 15 terms term NNS cord-342776-hkjhqgie 133 16 . . .