id	sid	tid	token	lemma	pos
cord-334391-0172afa1	1	1	key	key	JJ
cord-334391-0172afa1	1	2	:	:	:
cord-334391-0172afa1	1	3	cord-334391	cord-334391	NN
cord-334391-0172afa1	1	4	-	-	HYPH
cord-334391-0172afa1	1	5	0172afa1	0172afa1	JJ
cord-334391-0172afa1	1	6	authors	author	NNS
cord-334391-0172afa1	1	7	:	:	:
cord-334391-0172afa1	1	8	Gupta	Gupta	NNP
cord-334391-0172afa1	1	9	,	,	,
cord-334391-0172afa1	1	10	Rahul	Rahul	NNP
cord-334391-0172afa1	1	11	title	title	NN
cord-334391-0172afa1	1	12	:	:	:
cord-334391-0172afa1	1	13	The	the	DT
cord-334391-0172afa1	1	14	double	double	RB
cord-334391-0172afa1	1	15	edged	edge	VBN
cord-334391-0172afa1	1	16	interferon	interferon	NN
cord-334391-0172afa1	1	17	riddle	riddle	NN
cord-334391-0172afa1	1	18	in	in	IN
cord-334391-0172afa1	1	19	COVID-19	COVID-19	NNP
cord-334391-0172afa1	1	20	pathogenesis	pathogenesis	NN
cord-334391-0172afa1	1	21	date	date	NN
cord-334391-0172afa1	1	22	:	:	:
cord-334391-0172afa1	1	23	2020	2020	CD
cord-334391-0172afa1	1	24	-	-	HYPH
cord-334391-0172afa1	1	25	11	11	CD
cord-334391-0172afa1	1	26	-	-	HYPH
cord-334391-0172afa1	1	27	01	01	CD
cord-334391-0172afa1	1	28	journal	journal	NN
cord-334391-0172afa1	1	29	:	:	:
cord-334391-0172afa1	2	1	Crit	Crit	NNP
cord-334391-0172afa1	2	2	Care	Care	NNP
cord-334391-0172afa1	2	3	DOI	doi	NN
cord-334391-0172afa1	2	4	:	:	:
cord-334391-0172afa1	3	1	10.1186	10.1186	CD
cord-334391-0172afa1	3	2	/	/	SYM
cord-334391-0172afa1	3	3	s13054	s13054	NN
cord-334391-0172afa1	3	4	-	-	HYPH
cord-334391-0172afa1	3	5	020	020	CD
cord-334391-0172afa1	3	6	-	-	HYPH
cord-334391-0172afa1	3	7	03337-z	03337-z	CD
cord-334391-0172afa1	4	1	sha	sha	NNP
cord-334391-0172afa1	4	2	:	:	:
cord-334391-0172afa1	5	1	bfaf2aef6ba737d008af511a3472dd1e45272816	bfaf2aef6ba737d008af511a3472dd1e45272816	NNP
cord-334391-0172afa1	5	2	doc_id	doc_id	NNP
cord-334391-0172afa1	5	3	:	:	:
cord-334391-0172afa1	5	4	334391	334391	CD
cord-334391-0172afa1	5	5	cord_uid	cord_uid	NNS
cord-334391-0172afa1	5	6	:	:	:
cord-334391-0172afa1	5	7	0172afa1	0172afa1	.
cord-334391-0172afa1	6	1	nan	nan	NNP
cord-334391-0172afa1	7	1	In	in	IN
cord-334391-0172afa1	7	2	their	-PRON-	PRP$
cord-334391-0172afa1	7	3	recent	recent	JJ
cord-334391-0172afa1	7	4	article	article	NN
cord-334391-0172afa1	7	5	[	[	-LRB-
cord-334391-0172afa1	7	6	1	1	CD
cord-334391-0172afa1	7	7	]	]	-RRB-
cord-334391-0172afa1	7	8	,	,	,
cord-334391-0172afa1	7	9	Jalkanen	Jalkanen	NNP
cord-334391-0172afa1	7	10	et	et	NNP
cord-334391-0172afa1	7	11	al	al	NNP
cord-334391-0172afa1	7	12	.	.	.
cord-334391-0172afa1	8	1	discuss	discuss	VB
cord-334391-0172afa1	8	2	about	about	IN
cord-334391-0172afa1	8	3	the	the	DT
cord-334391-0172afa1	8	4	prospective	prospective	JJ
cord-334391-0172afa1	8	5	usage	usage	NN
cord-334391-0172afa1	8	6	of	of	IN
cord-334391-0172afa1	8	7	interferon	interferon	NN
cord-334391-0172afa1	8	8	beta	beta	NN
cord-334391-0172afa1	8	9	1	1	CD
cord-334391-0172afa1	8	10	in	in	IN
cord-334391-0172afa1	8	11	managing	manage	VBG
cord-334391-0172afa1	8	12	COVID-19	COVID-19	NNP
cord-334391-0172afa1	8	13	and	and	CC
cord-334391-0172afa1	8	14	substantiating	substantiate	VBG
cord-334391-0172afa1	8	15	usage	usage	NN
cord-334391-0172afa1	8	16	of	of	IN
cord-334391-0172afa1	8	17	intravenous	intravenous	JJ
cord-334391-0172afa1	8	18	route	route	NN
cord-334391-0172afa1	8	19	of	of	IN
cord-334391-0172afa1	8	20	administration	administration	NN
cord-334391-0172afa1	8	21	over	over	IN
cord-334391-0172afa1	8	22	subcutaneous	subcutaneous	JJ
cord-334391-0172afa1	8	23	route	route	NN
cord-334391-0172afa1	8	24	.	.	.
cord-334391-0172afa1	9	1	I	-PRON-	PRP
cord-334391-0172afa1	9	2	would	would	MD
cord-334391-0172afa1	9	3	like	like	VB
cord-334391-0172afa1	9	4	to	to	TO
cord-334391-0172afa1	9	5	humbly	humbly	RB
cord-334391-0172afa1	9	6	add	add	VB
cord-334391-0172afa1	9	7	some	some	DT
cord-334391-0172afa1	9	8	views	view	NNS
cord-334391-0172afa1	9	9	to	to	IN
cord-334391-0172afa1	9	10	it	-PRON-	PRP
cord-334391-0172afa1	9	11	:	:	:
cord-334391-0172afa1	9	12	there	there	EX
cord-334391-0172afa1	9	13	has	have	VBZ
cord-334391-0172afa1	9	14	been	be	VBN
cord-334391-0172afa1	9	15	two	two	CD
cord-334391-0172afa1	9	16	varying	vary	VBG
cord-334391-0172afa1	9	17	reported	report	VBN
cord-334391-0172afa1	9	18	type	type	NN
cord-334391-0172afa1	10	1	I	-PRON-	PRP
cord-334391-0172afa1	11	1	interferon	interferon	NN
cord-334391-0172afa1	11	2	responses	response	NNS
cord-334391-0172afa1	11	3	in	in	IN
cord-334391-0172afa1	11	4	COVID-19	covid-19	JJ
cord-334391-0172afa1	11	5	pathogenesis	pathogenesis	NN
cord-334391-0172afa1	11	6	[	[	-LRB-
cord-334391-0172afa1	11	7	2	2	CD
cord-334391-0172afa1	11	8	]	]	-RRB-
cord-334391-0172afa1	11	9	:	:	:
cord-334391-0172afa1	11	10	one	one	CD
cord-334391-0172afa1	11	11	stating	state	VBG
cord-334391-0172afa1	11	12	the	the	DT
cord-334391-0172afa1	11	13	suppression	suppression	NN
cord-334391-0172afa1	11	14	of	of	IN
cord-334391-0172afa1	11	15	host	host	NN
cord-334391-0172afa1	11	16	antiviral	antiviral	JJ
cord-334391-0172afa1	11	17	type	type	NN
cord-334391-0172afa1	11	18	I	-PRON-	PRP
cord-334391-0172afa1	11	19	interferons	interferon	NNS
cord-334391-0172afa1	11	20	(	(	-LRB-
cord-334391-0172afa1	11	21	IFNs	ifn	NNS
cord-334391-0172afa1	11	22	)	)	-RRB-
cord-334391-0172afa1	11	23	and	and	CC
cord-334391-0172afa1	11	24	interferon	interferon	NN
cord-334391-0172afa1	11	25	stimulated	stimulate	VBD
cord-334391-0172afa1	11	26	genes	gene	NNS
cord-334391-0172afa1	11	27	(	(	-LRB-
cord-334391-0172afa1	11	28	ISGs	ISGs	NNP
cord-334391-0172afa1	11	29	)	)	-RRB-
cord-334391-0172afa1	11	30	and	and	CC
cord-334391-0172afa1	11	31	other	other	JJ
cord-334391-0172afa1	11	32	stating	state	VBG
cord-334391-0172afa1	11	33	increased	increase	VBN
cord-334391-0172afa1	11	34	expression	expression	NN
cord-334391-0172afa1	11	35	of	of	IN
cord-334391-0172afa1	11	36	different	different	JJ
cord-334391-0172afa1	11	37	ISGs	isg	NNS
cord-334391-0172afa1	11	38	,	,	,
cord-334391-0172afa1	11	39	with	with	IN
cord-334391-0172afa1	11	40	further	further	JJ
cord-334391-0172afa1	11	41	inductions	induction	NNS
cord-334391-0172afa1	11	42	of	of	IN
cord-334391-0172afa1	11	43	chemokines	chemokine	NNS
cord-334391-0172afa1	11	44	and	and	CC
cord-334391-0172afa1	11	45	cytokines	cytokine	NNS
cord-334391-0172afa1	11	46	[	[	-LRB-
cord-334391-0172afa1	11	47	2	2	CD
cord-334391-0172afa1	11	48	]	]	-RRB-
cord-334391-0172afa1	11	49	.	.	.
cord-334391-0172afa1	12	1	The	the	DT
cord-334391-0172afa1	12	2	viral	viral	JJ
cord-334391-0172afa1	12	3	Nsps	Nsps	NNP
cord-334391-0172afa1	12	4	(	(	-LRB-
cord-334391-0172afa1	12	5	particularly	particularly	RB
cord-334391-0172afa1	12	6	Nsp1	Nsp1	NNP
cord-334391-0172afa1	12	7	)	)	-RRB-
cord-334391-0172afa1	12	8	and	and	CC
cord-334391-0172afa1	12	9	the	the	DT
cord-334391-0172afa1	12	10	ORFs	ORFs	NNP
cord-334391-0172afa1	12	11	(	(	-LRB-
cord-334391-0172afa1	12	12	particularly	particularly	RB
cord-334391-0172afa1	12	13	ORF	ORF	NNP
cord-334391-0172afa1	12	14	6	6	CD
cord-334391-0172afa1	12	15	)	)	-RRB-
cord-334391-0172afa1	12	16	are	be	VBP
cord-334391-0172afa1	12	17	known	know	VBN
cord-334391-0172afa1	12	18	to	to	TO
cord-334391-0172afa1	12	19	antagonise	antagonise	VB
cord-334391-0172afa1	12	20	the	the	DT
cord-334391-0172afa1	12	21	host	host	NN
cord-334391-0172afa1	12	22	antiviral	antiviral	JJ
cord-334391-0172afa1	12	23	IFNs	ifn	NNS
cord-334391-0172afa1	12	24	initially	initially	RB
cord-334391-0172afa1	12	25	by	by	IN
cord-334391-0172afa1	12	26	suppressing	suppress	VBG
cord-334391-0172afa1	12	27	/	/	SYM
cord-334391-0172afa1	12	28	delaying	delay	VBG
cord-334391-0172afa1	12	29	their	-PRON-	PRP$
cord-334391-0172afa1	12	30	expressions	expression	NNS
cord-334391-0172afa1	12	31	,	,	,
cord-334391-0172afa1	12	32	leading	lead	VBG
cord-334391-0172afa1	12	33	to	to	IN
cord-334391-0172afa1	12	34	viral	viral	JJ
cord-334391-0172afa1	12	35	persistence	persistence	NN
cord-334391-0172afa1	12	36	and	and	CC
cord-334391-0172afa1	12	37	propagating	propagate	VBG
cord-334391-0172afa1	12	38	inflammations	inflammation	NNS
cord-334391-0172afa1	12	39	.	.	.
cord-334391-0172afa1	13	1	Hence	hence	RB
cord-334391-0172afa1	13	2	,	,	,
cord-334391-0172afa1	13	3	neither	neither	DT
cord-334391-0172afa1	13	4	type	type	NN
cord-334391-0172afa1	13	5	I	-PRON-	PRP
cord-334391-0172afa1	13	6	IFN	IFN	NNP
cord-334391-0172afa1	13	7	nor	nor	CC
cord-334391-0172afa1	13	8	type	type	NN
cord-334391-0172afa1	13	9	III	III	NNP
cord-334391-0172afa1	13	10	IFN	IFN	NNP
cord-334391-0172afa1	13	11	,	,	,
cord-334391-0172afa1	13	12	which	which	WDT
cord-334391-0172afa1	13	13	are	be	VBP
cord-334391-0172afa1	13	14	known	know	VBN
cord-334391-0172afa1	13	15	hard	hard	RB
cord-334391-0172afa1	13	16	-	-	HYPH
cord-334391-0172afa1	13	17	wired	wired	JJ
cord-334391-0172afa1	13	18	for	for	IN
cord-334391-0172afa1	13	19	providing	provide	VBG
cord-334391-0172afa1	13	20	antiviral	antiviral	JJ
cord-334391-0172afa1	13	21	immunity	immunity	NN
cord-334391-0172afa1	13	22	,	,	,
cord-334391-0172afa1	13	23	was	be	VBD
cord-334391-0172afa1	13	24	activated	activate	VBN
cord-334391-0172afa1	13	25	in	in	IN
cord-334391-0172afa1	13	26	early	early	JJ
cord-334391-0172afa1	13	27	stages	stage	NNS
cord-334391-0172afa1	13	28	of	of	IN
cord-334391-0172afa1	13	29	COVID-19	COVID-19	NNP
cord-334391-0172afa1	13	30	.	.	.
cord-334391-0172afa1	14	1	However	however	RB
cord-334391-0172afa1	14	2	,	,	,
cord-334391-0172afa1	14	3	SARS	SARS	NNP
cord-334391-0172afa1	14	4	-	-	HYPH
cord-334391-0172afa1	14	5	CoV-2	CoV-2	NNP
cord-334391-0172afa1	14	6	at	at	IN
cord-334391-0172afa1	14	7	2	2	CD
cord-334391-0172afa1	14	8	days	day	NNS
cord-334391-0172afa1	14	9	post	post	NN
cord-334391-0172afa1	14	10	-	-	NN
cord-334391-0172afa1	14	11	infection	infection	JJ
cord-334391-0172afa1	14	12	(	(	-LRB-
cord-334391-0172afa1	14	13	dpi	dpi	NNP
cord-334391-0172afa1	14	14	)	)	-RRB-
cord-334391-0172afa1	14	15	,	,	,
cord-334391-0172afa1	14	16	induced	induce	VBN
cord-334391-0172afa1	14	17	ISGs	ISGs	NNP
cord-334391-0172afa1	14	18	having	have	VBG
cord-334391-0172afa1	14	19	antiviral	antiviral	JJ
cord-334391-0172afa1	14	20	action	action	NN
cord-334391-0172afa1	14	21	(	(	-LRB-
cord-334391-0172afa1	14	22	Rsad2	rsad2	JJ
cord-334391-0172afa1	14	23	,	,	,
cord-334391-0172afa1	14	24	Ifit	Ifit	NNP
cord-334391-0172afa1	14	25	,	,	,
cord-334391-0172afa1	14	26	Mx2	mx2	CD
cord-334391-0172afa1	14	27	,	,	,
cord-334391-0172afa1	14	28	Oas3	Oas3	NNP
cord-334391-0172afa1	14	29	,	,	,
cord-334391-0172afa1	14	30	etc	etc	FW
cord-334391-0172afa1	14	31	.	.	.
cord-334391-0172afa1	14	32	)	)	-RRB-
cord-334391-0172afa1	15	1	and	and	CC
cord-334391-0172afa1	15	2	at	at	IN
cord-334391-0172afa1	15	3	7dpi	7dpi	CD
cord-334391-0172afa1	15	4	,	,	,
cord-334391-0172afa1	15	5	ISGs	isg	NNS
cord-334391-0172afa1	15	6	having	have	VBG
cord-334391-0172afa1	15	7	potentiating	potentiate	VBG
cord-334391-0172afa1	15	8	IFN	IFN	NNP
cord-334391-0172afa1	15	9	mediated	mediate	VBD
cord-334391-0172afa1	15	10	inflammatory	inflammatory	JJ
cord-334391-0172afa1	15	11	signalling	signalling	NN
cord-334391-0172afa1	15	12	(	(	-LRB-
cord-334391-0172afa1	15	13	Ifihi	Ifihi	NNP
cord-334391-0172afa1	15	14	,	,	,
cord-334391-0172afa1	15	15	Irf7,Stat1,Ifnar1/	Irf7,Stat1,Ifnar1/	NNP
cord-334391-0172afa1	15	16	2,Tyk2,etc	2,tyk2,etc	CD
cord-334391-0172afa1	15	17	.	.	.
cord-334391-0172afa1	15	18	)	)	-RRB-
cord-334391-0172afa1	16	1	[	[	-LRB-
cord-334391-0172afa1	16	2	3	3	CD
cord-334391-0172afa1	16	3	]	]	-RRB-
cord-334391-0172afa1	16	4	.	.	.
cord-334391-0172afa1	17	1	As	as	IN
cord-334391-0172afa1	17	2	the	the	DT
cord-334391-0172afa1	17	3	disease	disease	NN
cord-334391-0172afa1	17	4	progresses	progress	VBZ
cord-334391-0172afa1	17	5	towards	towards	IN
cord-334391-0172afa1	17	6	severity	severity	NN
cord-334391-0172afa1	17	7	,	,	,
cord-334391-0172afa1	17	8	the	the	DT
cord-334391-0172afa1	17	9	IFNs	ifn	NNS
cord-334391-0172afa1	17	10	exacerbate	exacerbate	VBP
cord-334391-0172afa1	17	11	the	the	DT
cord-334391-0172afa1	17	12	pathophysiology	pathophysiology	NN
cord-334391-0172afa1	17	13	with	with	IN
cord-334391-0172afa1	17	14	specific	specific	JJ
cord-334391-0172afa1	17	15	inflammatory	inflammatory	JJ
cord-334391-0172afa1	17	16	signatures	signature	NNS
cord-334391-0172afa1	17	17	[	[	-LRB-
cord-334391-0172afa1	17	18	2	2	CD
cord-334391-0172afa1	17	19	]	]	-RRB-
cord-334391-0172afa1	17	20	.	.	.
cord-334391-0172afa1	18	1	Hence	hence	RB
cord-334391-0172afa1	18	2	,	,	,
cord-334391-0172afa1	18	3	cellular	cellular	JJ
cord-334391-0172afa1	18	4	response	response	NN
cord-334391-0172afa1	18	5	to	to	TO
cord-334391-0172afa1	18	6	type	type	NN
cord-334391-0172afa1	18	7	1	1	CD
cord-334391-0172afa1	18	8	IFN	IFN	NNP
cord-334391-0172afa1	18	9	(	(	-LRB-
cord-334391-0172afa1	18	10	thru	thru	IN
cord-334391-0172afa1	18	11	ISGs	ISGs	NNPS
cord-334391-0172afa1	18	12	)	)	-RRB-
cord-334391-0172afa1	18	13	towards	towards	IN
cord-334391-0172afa1	18	14	later	later	JJ
cord-334391-0172afa1	18	15	stages	stage	NNS
cord-334391-0172afa1	18	16	of	of	IN
cord-334391-0172afa1	18	17	infection	infection	NN
cord-334391-0172afa1	18	18	is	be	VBZ
cord-334391-0172afa1	18	19	immunopathogenic	immunopathogenic	JJ
cord-334391-0172afa1	18	20	.	.	.
cord-334391-0172afa1	19	1	Neutrophils	neutrophil	NNS
cord-334391-0172afa1	19	2	provide	provide	VBP
cord-334391-0172afa1	19	3	the	the	DT
cord-334391-0172afa1	19	4	first	first	JJ
cord-334391-0172afa1	19	5	line	line	NN
cord-334391-0172afa1	19	6	of	of	IN
cord-334391-0172afa1	19	7	innate	innate	JJ
cord-334391-0172afa1	19	8	immune	immune	JJ
cord-334391-0172afa1	19	9	defence	defence	NN
cord-334391-0172afa1	19	10	.	.	.
cord-334391-0172afa1	20	1	Neutrophil	Neutrophil	NNP
cord-334391-0172afa1	20	2	attracting	attract	VBG
cord-334391-0172afa1	20	3	chemokines	chemokine	NNS
cord-334391-0172afa1	20	4	(	(	-LRB-
cord-334391-0172afa1	20	5	CXCL1	CXCL1	NNP
cord-334391-0172afa1	20	6	,	,	,
cord-334391-0172afa1	20	7	CXCL2	CXCL2	NNP
cord-334391-0172afa1	20	8	,	,	,
cord-334391-0172afa1	20	9	CXCL8	CXCL8	NNP
cord-334391-0172afa1	20	10	,	,	,
cord-334391-0172afa1	20	11	S100A9	S100A9	NNP
cord-334391-0172afa1	20	12	)	)	-RRB-
cord-334391-0172afa1	20	13	and	and	CC
cord-334391-0172afa1	20	14	cognate	cognate	JJ
cord-334391-0172afa1	20	15	receptor	receptor	NN
cord-334391-0172afa1	20	16	(	(	-LRB-
cord-334391-0172afa1	20	17	CXCR2	CXCR2	NNS
cord-334391-0172afa1	20	18	)	)	-RRB-
cord-334391-0172afa1	20	19	were	be	VBD
cord-334391-0172afa1	20	20	found	find	VBN
cord-334391-0172afa1	20	21	to	to	TO
cord-334391-0172afa1	20	22	be	be	VB
cord-334391-0172afa1	20	23	activated	activate	VBN
cord-334391-0172afa1	20	24	in	in	IN
cord-334391-0172afa1	20	25	early	early	JJ
cord-334391-0172afa1	20	26	stages	stage	NNS
cord-334391-0172afa1	20	27	(	(	-LRB-
cord-334391-0172afa1	20	28	1	1	CD
cord-334391-0172afa1	20	29	-	-	SYM
cord-334391-0172afa1	20	30	3	3	CD
cord-334391-0172afa1	20	31	dpi	dpi	NN
cord-334391-0172afa1	20	32	)	)	-RRB-
cord-334391-0172afa1	21	1	[	[	-LRB-
cord-334391-0172afa1	21	2	3	3	CD
cord-334391-0172afa1	21	3	]	]	-RRB-
cord-334391-0172afa1	21	4	.	.	.
cord-334391-0172afa1	22	1	COVID-19	COVID-19	NNP
cord-334391-0172afa1	22	2	is	be	VBZ
cord-334391-0172afa1	22	3	manifested	manifest	VBN
cord-334391-0172afa1	22	4	with	with	IN
cord-334391-0172afa1	22	5	necrophilia	necrophilia	NN
cord-334391-0172afa1	22	6	having	have	VBG
cord-334391-0172afa1	22	7	high	high	JJ
cord-334391-0172afa1	22	8	neutrophil	neutrophil	NN
cord-334391-0172afa1	22	9	-	-	HYPH
cord-334391-0172afa1	22	10	to	to	IN
cord-334391-0172afa1	22	11	-	-	HYPH
cord-334391-0172afa1	22	12	lymphocyte	lymphocyte	NN
cord-334391-0172afa1	22	13	ratio	ratio	NN
cord-334391-0172afa1	22	14	.	.	.
cord-334391-0172afa1	23	1	Type	type	NN
cord-334391-0172afa1	23	2	1	1	CD
cord-334391-0172afa1	23	3	IFNs	ifn	NNS
cord-334391-0172afa1	23	4	are	be	VBP
cord-334391-0172afa1	23	5	known	know	VBN
cord-334391-0172afa1	23	6	to	to	TO
cord-334391-0172afa1	23	7	inhibit	inhibit	VB
cord-334391-0172afa1	23	8	neutrophil	neutrophil	NN
cord-334391-0172afa1	23	9	migration	migration	NN
cord-334391-0172afa1	23	10	by	by	IN
cord-334391-0172afa1	23	11	downregulating	downregulate	VBG
cord-334391-0172afa1	23	12	neutrophil	neutrophil	NN
cord-334391-0172afa1	23	13	chemoattractants	chemoattractant	NNS
cord-334391-0172afa1	23	14	production	production	NN
cord-334391-0172afa1	23	15	(	(	-LRB-
cord-334391-0172afa1	23	16	CXCL1/2	CXCL1/2	NNP
cord-334391-0172afa1	23	17	)	)	-RRB-
cord-334391-0172afa1	23	18	[	[	-LRB-
cord-334391-0172afa1	23	19	4	4	CD
cord-334391-0172afa1	23	20	]	]	-RRB-
cord-334391-0172afa1	23	21	.	.	.
cord-334391-0172afa1	24	1	Other	other	JJ
cord-334391-0172afa1	24	2	than	than	IN
cord-334391-0172afa1	24	3	phagocytosis	phagocytosis	NN
cord-334391-0172afa1	24	4	,	,	,
cord-334391-0172afa1	24	5	neutrophils	neutrophil	NNS
cord-334391-0172afa1	24	6	have	have	VBP
cord-334391-0172afa1	24	7	another	another	DT
cord-334391-0172afa1	24	8	capacity	capacity	NN
cord-334391-0172afa1	24	9	to	to	TO
cord-334391-0172afa1	24	10	contain	contain	VB
cord-334391-0172afa1	24	11	pathogens	pathogen	NNS
cord-334391-0172afa1	24	12	,	,	,
cord-334391-0172afa1	24	13	by	by	IN
cord-334391-0172afa1	24	14	forming	form	VBG
cord-334391-0172afa1	24	15	neutrophil	neutrophil	NN
cord-334391-0172afa1	24	16	extracellular	extracellular	JJ
cord-334391-0172afa1	24	17	traps	trap	NNS
cord-334391-0172afa1	24	18	(	(	-LRB-
cord-334391-0172afa1	24	19	NETs	nets	NN
cord-334391-0172afa1	24	20	)	)	-RRB-
cord-334391-0172afa1	24	21	.	.	.
cord-334391-0172afa1	25	1	NETs	net	NNS
cord-334391-0172afa1	25	2	are	be	VBP
cord-334391-0172afa1	25	3	mesh	mesh	NN
cord-334391-0172afa1	25	4	-	-	HYPH
cord-334391-0172afa1	25	5	like	like	JJ
cord-334391-0172afa1	25	6	structures	structure	NNS
cord-334391-0172afa1	25	7	of	of	IN
cord-334391-0172afa1	25	8	DNA	dna	NN
cord-334391-0172afa1	25	9	and	and	CC
cord-334391-0172afa1	25	10	proteins	protein	NNS
cord-334391-0172afa1	25	11	from	from	IN
cord-334391-0172afa1	25	12	degrading	degrade	VBG
cord-334391-0172afa1	25	13	neutrophils	neutrophil	NNS
cord-334391-0172afa1	25	14	(	(	-LRB-
cord-334391-0172afa1	25	15	by	by	IN
cord-334391-0172afa1	25	16	neutrophil	neutrophil	NN
cord-334391-0172afa1	25	17	elastase	elastase	NN
cord-334391-0172afa1	25	18	)	)	-RRB-
cord-334391-0172afa1	25	19	which	which	WDT
cord-334391-0172afa1	25	20	entrap	entrap	VBP
cord-334391-0172afa1	25	21	pathogens	pathogen	NNS
cord-334391-0172afa1	25	22	.	.	.
cord-334391-0172afa1	26	1	Interestingly	interestingly	RB
cord-334391-0172afa1	26	2	against	against	IN
cord-334391-0172afa1	26	3	leishmania	leishmania	NN
cord-334391-0172afa1	26	4	,	,	,
cord-334391-0172afa1	26	5	IFNAR	IFNAR	NNP
cord-334391-0172afa1	26	6	−/−	−/−	NNP
cord-334391-0172afa1	26	7	mice	mouse	NNS
cord-334391-0172afa1	26	8	showed	show	VBD
cord-334391-0172afa1	26	9	enhanced	enhanced	JJ
cord-334391-0172afa1	26	10	neutrophil	neutrophil	NN
cord-334391-0172afa1	26	11	elastase	elastase	NN
cord-334391-0172afa1	26	12	activity	activity	NN
cord-334391-0172afa1	26	13	,	,	,
cord-334391-0172afa1	26	14	with	with	IN
cord-334391-0172afa1	26	15	better	well	JJR
cord-334391-0172afa1	26	16	infiltrations	infiltration	NNS
cord-334391-0172afa1	26	17	.	.	.
cord-334391-0172afa1	27	1	Aberrant	aberrant	JJ
cord-334391-0172afa1	27	2	production	production	NN
cord-334391-0172afa1	27	3	of	of	IN
cord-334391-0172afa1	27	4	NETs	net	NNS
cord-334391-0172afa1	27	5	have	have	VBP
cord-334391-0172afa1	27	6	been	be	VBN
cord-334391-0172afa1	27	7	known	know	VBN
cord-334391-0172afa1	27	8	to	to	TO
cord-334391-0172afa1	27	9	cause	cause	VB
cord-334391-0172afa1	27	10	severe	severe	JJ
cord-334391-0172afa1	27	11	COVID	covid	NN
cord-334391-0172afa1	27	12	-	-	HYPH
cord-334391-0172afa1	27	13	like	like	JJ
cord-334391-0172afa1	27	14	pathophysiologies	pathophysiologies	NN
cord-334391-0172afa1	27	15	-	-	HYPH
cord-334391-0172afa1	27	16	thrombosis	thrombosis	NN
cord-334391-0172afa1	27	17	,	,	,
cord-334391-0172afa1	27	18	lung	lung	NN
cord-334391-0172afa1	27	19	damage	damage	NN
cord-334391-0172afa1	27	20	,	,	,
cord-334391-0172afa1	27	21	ARDS	ARDS	NNP
cord-334391-0172afa1	27	22	,	,	,
cord-334391-0172afa1	27	23	multiorgan	multiorgan	NNP
cord-334391-0172afa1	27	24	damage	damage	NN
cord-334391-0172afa1	27	25	,	,	,
cord-334391-0172afa1	27	26	etc	etc	FW
cord-334391-0172afa1	27	27	.	.	.
cord-334391-0172afa1	28	1	[	[	-LRB-
cord-334391-0172afa1	28	2	5	5	CD
cord-334391-0172afa1	28	3	]	]	-RRB-
cord-334391-0172afa1	28	4	.	.	.
cord-334391-0172afa1	29	1	Indeed	indeed	RB
cord-334391-0172afa1	29	2	,	,	,
cord-334391-0172afa1	29	3	severe	severe	JJ
cord-334391-0172afa1	29	4	COVID-19	covid-19	JJ
cord-334391-0172afa1	29	5	patients	patient	NNS
cord-334391-0172afa1	29	6	reported	report	VBN
cord-334391-0172afa1	29	7	of	of	IN
cord-334391-0172afa1	29	8	higher	high	JJR
cord-334391-0172afa1	29	9	amount	amount	NN
cord-334391-0172afa1	29	10	of	of	IN
cord-334391-0172afa1	29	11	NETosis	netosis	NN
cord-334391-0172afa1	29	12	remnants	remnant	NNS
cord-334391-0172afa1	29	13	like	like	IN
cord-334391-0172afa1	29	14	cell	cell	NN
cord-334391-0172afa1	29	15	-	-	HYPH
cord-334391-0172afa1	29	16	free	free	JJ
cord-334391-0172afa1	29	17	DNA	dna	NN
cord-334391-0172afa1	29	18	,	,	,
cord-334391-0172afa1	29	19	myeloperoxidase	myeloperoxidase	NN
cord-334391-0172afa1	29	20	-	-	HYPH
cord-334391-0172afa1	29	21	DNA	dna	NN
cord-334391-0172afa1	29	22	and	and	CC
cord-334391-0172afa1	29	23	citrullinated	citrullinate	VBD
cord-334391-0172afa1	29	24	histone	histone	NN
cord-334391-0172afa1	29	25	H3	H3	NNP
cord-334391-0172afa1	29	26	[	[	-LRB-
cord-334391-0172afa1	29	27	5	5	CD
cord-334391-0172afa1	29	28	]	]	-RRB-
cord-334391-0172afa1	29	29	.	.	.
cord-334391-0172afa1	30	1	These	these	DT
cord-334391-0172afa1	30	2	molecules	molecule	NNS
cord-334391-0172afa1	30	3	further	further	RB
cord-334391-0172afa1	30	4	propagate	propagate	VBP
cord-334391-0172afa1	30	5	inflammation	inflammation	NN
cord-334391-0172afa1	30	6	by	by	IN
cord-334391-0172afa1	30	7	inducing	induce	VBG
cord-334391-0172afa1	30	8	IL-1β	il-1β	ADD
cord-334391-0172afa1	30	9	production	production	NN
cord-334391-0172afa1	30	10	thru	thru	IN
cord-334391-0172afa1	30	11	inflammasome	inflammasome	NNP
cord-334391-0172afa1	30	12	activation	activation	NN
cord-334391-0172afa1	30	13	.	.	.
cord-334391-0172afa1	31	1	The	the	DT
cord-334391-0172afa1	31	2	initial	initial	JJ
cord-334391-0172afa1	31	3	type	type	NN
cord-334391-0172afa1	31	4	1IFN	1ifn	CD
cord-334391-0172afa1	31	5	suppression	suppression	NN
cord-334391-0172afa1	31	6	could	could	MD
cord-334391-0172afa1	31	7	lead	lead	VB
cord-334391-0172afa1	31	8	to	to	IN
cord-334391-0172afa1	31	9	enhanced	enhance	VBN
cord-334391-0172afa1	31	10	infiltration	infiltration	NN
cord-334391-0172afa1	31	11	of	of	IN
cord-334391-0172afa1	31	12	neutrophils	neutrophil	NNS
cord-334391-0172afa1	31	13	,	,	,
cord-334391-0172afa1	31	14	NET	net	JJ
cord-334391-0172afa1	31	15	formation	formation	NN
cord-334391-0172afa1	31	16	and	and	CC
cord-334391-0172afa1	31	17	ensuing	ensue	VBG
cord-334391-0172afa1	31	18	pathophysiologies	pathophysiologie	NNS
cord-334391-0172afa1	31	19	.	.	.
cord-334391-0172afa1	32	1	Early	early	JJ
cord-334391-0172afa1	32	2	administration	administration	NN
cord-334391-0172afa1	32	3	of	of	IN
cord-334391-0172afa1	32	4	IFNβ	IFNβ	NNP
cord-334391-0172afa1	32	5	has	have	VBZ
cord-334391-0172afa1	32	6	proved	prove	VBN
cord-334391-0172afa1	32	7	beneficial	beneficial	JJ
cord-334391-0172afa1	32	8	[	[	-LRB-
cord-334391-0172afa1	32	9	1	1	CD
cord-334391-0172afa1	32	10	,	,	,
cord-334391-0172afa1	32	11	2	2	CD
cord-334391-0172afa1	32	12	]	]	-RRB-
cord-334391-0172afa1	32	13	;	;	:
cord-334391-0172afa1	32	14	hence	hence	RB
cord-334391-0172afa1	32	15	,	,	,
cord-334391-0172afa1	32	16	the	the	DT
cord-334391-0172afa1	32	17	"	"	``
cord-334391-0172afa1	32	18	double	double	JJ
cord-334391-0172afa1	32	19	edged	edged	JJ
cord-334391-0172afa1	32	20	sword	sword	NN
cord-334391-0172afa1	32	21	"	"	''
cord-334391-0172afa1	32	22	be	be	VB
cord-334391-0172afa1	32	23	tried	try	VBN
cord-334391-0172afa1	32	24	prudently	prudently	RB
cord-334391-0172afa1	32	25	with	with	IN
cord-334391-0172afa1	32	26	respect	respect	NN
cord-334391-0172afa1	32	27	to	to	IN
cord-334391-0172afa1	32	28	time	time	NN
cord-334391-0172afa1	32	29	and	and	CC
cord-334391-0172afa1	32	30	dosage	dosage	VB
cord-334391-0172afa1	32	31	.	.	.
cord-334391-0172afa1	33	1	Interferon	Interferon	NNP
cord-334391-0172afa1	33	2	beta-1a	beta-1a	NNP
cord-334391-0172afa1	33	3	for	for	IN
cord-334391-0172afa1	33	4	COVID-19	COVID-19	NNP
cord-334391-0172afa1	33	5	:	:	:
cord-334391-0172afa1	33	6	critical	critical	JJ
cord-334391-0172afa1	33	7	importance	importance	NN
cord-334391-0172afa1	33	8	of	of	IN
cord-334391-0172afa1	33	9	the	the	DT
cord-334391-0172afa1	33	10	administration	administration	NN
cord-334391-0172afa1	33	11	route	route	NN
cord-334391-0172afa1	33	12	.	.	.
cord-334391-0172afa1	34	1	Crit	Crit	NNP
cord-334391-0172afa1	34	2	Care	Care	NNP
cord-334391-0172afa1	35	1	The	the	DT
cord-334391-0172afa1	35	2	type	type	NN
cord-334391-0172afa1	36	1	I	-PRON-	PRP
cord-334391-0172afa1	37	1	interferon	interferon	NNP
cord-334391-0172afa1	37	2	response	response	NN
cord-334391-0172afa1	37	3	in	in	IN
cord-334391-0172afa1	37	4	COVID-19	COVID-19	NNP
cord-334391-0172afa1	37	5	:	:	:
cord-334391-0172afa1	37	6	implications	implication	NNS
cord-334391-0172afa1	37	7	for	for	IN
cord-334391-0172afa1	37	8	treatment	treatment	NN
cord-334391-0172afa1	37	9	Heightened	heighten	VBN
cord-334391-0172afa1	37	10	innate	innate	JJ
cord-334391-0172afa1	37	11	immune	immune	JJ
cord-334391-0172afa1	37	12	responses	response	NNS
cord-334391-0172afa1	37	13	in	in	IN
cord-334391-0172afa1	37	14	the	the	DT
cord-334391-0172afa1	37	15	respiratory	respiratory	JJ
cord-334391-0172afa1	37	16	tract	tract	NN
cord-334391-0172afa1	37	17	of	of	IN
cord-334391-0172afa1	37	18	COVID-19	covid-19	CD
cord-334391-0172afa1	37	19	patients	patient	NNS
cord-334391-0172afa1	38	1	Type	type	NN
cord-334391-0172afa1	39	1	I	-PRON-	PRP
cord-334391-0172afa1	39	2	IFNs	ifns	VBP
cord-334391-0172afa1	39	3	mediate	mediate	VB
cord-334391-0172afa1	39	4	development	development	NN
cord-334391-0172afa1	39	5	of	of	IN
cord-334391-0172afa1	39	6	postinfluenza	postinfluenza	NNP
cord-334391-0172afa1	39	7	bacterial	bacterial	JJ
cord-334391-0172afa1	39	8	pneumonia	pneumonia	NN
cord-334391-0172afa1	39	9	in	in	IN
cord-334391-0172afa1	39	10	mice	mouse	NNS
cord-334391-0172afa1	40	1	Neutrophil	Neutrophil	NNP
cord-334391-0172afa1	40	2	extracellular	extracellular	JJ
cord-334391-0172afa1	40	3	traps	trap	NNS
cord-334391-0172afa1	40	4	in	in	IN
cord-334391-0172afa1	40	5	COVID-19	COVID-19	NNP
cord-334391-0172afa1	40	6	Publisher	Publisher	NNP
cord-334391-0172afa1	40	7	's	's	POS
cord-334391-0172afa1	40	8	Note	Note	NNP
cord-334391-0172afa1	40	9	Springer	Springer	NNP
cord-334391-0172afa1	40	10	Nature	Nature	NNP
cord-334391-0172afa1	40	11	remains	remain	VBZ
cord-334391-0172afa1	40	12	neutral	neutral	JJ
cord-334391-0172afa1	40	13	with	with	IN
cord-334391-0172afa1	40	14	regard	regard	NN
cord-334391-0172afa1	40	15	to	to	IN
cord-334391-0172afa1	40	16	jurisdictional	jurisdictional	JJ
cord-334391-0172afa1	40	17	claims	claim	NNS
cord-334391-0172afa1	40	18	in	in	IN
cord-334391-0172afa1	40	19	published	publish	VBN
cord-334391-0172afa1	40	20	maps	map	NNS
cord-334391-0172afa1	40	21	and	and	CC
cord-334391-0172afa1	40	22	institutional	institutional	JJ
cord-334391-0172afa1	40	23	affiliations	affiliation	NNS
cord-334391-0172afa1	41	1	Rahul	Rahul	NNP
cord-334391-0172afa1	41	2	is	be	VBZ
cord-334391-0172afa1	41	3	very	very	RB
cord-334391-0172afa1	41	4	grateful	grateful	JJ
cord-334391-0172afa1	41	5	to	to	IN
cord-334391-0172afa1	41	6	Dr	Dr	NNP
cord-334391-0172afa1	41	7	Kate	Kate	NNP
cord-334391-0172afa1	41	8	Fitzgerald	Fitzgerald	NNP
cord-334391-0172afa1	41	9	and	and	CC
cord-334391-0172afa1	41	10	Dr	Dr	NNP
cord-334391-0172afa1	41	11	Douglas	Douglas	NNP
cord-334391-0172afa1	41	12	Golenbock	Golenbock	NNP
cord-334391-0172afa1	41	13	(	(	-LRB-
cord-334391-0172afa1	41	14	UMASSMED	UMASSMED	NNP
cord-334391-0172afa1	41	15	)	)	-RRB-
cord-334391-0172afa1	41	16	for	for	IN
cord-334391-0172afa1	41	17	the	the	DT
cord-334391-0172afa1	41	18	initial	initial	JJ
cord-334391-0172afa1	41	19	insightful	insightful	JJ
cord-334391-0172afa1	41	20	discussion	discussion	NN
cord-334391-0172afa1	41	21	.	.	.
cord-334391-0172afa1	42	1	Rahul	Rahul	NNP
cord-334391-0172afa1	42	2	did	do	VBD
cord-334391-0172afa1	42	3	the	the	DT
cord-334391-0172afa1	42	4	literature	literature	NN
cord-334391-0172afa1	42	5	survey	survey	NN
cord-334391-0172afa1	42	6	and	and	CC
cord-334391-0172afa1	42	7	wrote	write	VBD
cord-334391-0172afa1	42	8	the	the	DT
cord-334391-0172afa1	42	9	manuscript	manuscript	NN
cord-334391-0172afa1	42	10	.	.	.
cord-334391-0172afa1	43	1	The	the	DT
cord-334391-0172afa1	43	2	study	study	NN
cord-334391-0172afa1	43	3	has	have	VBZ
cord-334391-0172afa1	43	4	not	not	RB
cord-334391-0172afa1	43	5	received	receive	VBN
cord-334391-0172afa1	43	6	any	any	DT
cord-334391-0172afa1	43	7	funding	funding	NN
cord-334391-0172afa1	43	8	as	as	RB
cord-334391-0172afa1	43	9	yet	yet	RB
cord-334391-0172afa1	43	10	.	.	.
cord-334391-0172afa1	44	1	*	*	NFP
cord-334391-0172afa1	44	2	Correspondence	correspondence	NN
cord-334391-0172afa1	44	3	:	:	:
cord-334391-0172afa1	45	1	rbiochem@gmail.com	rbiochem@gmail.com	ADD
cord-334391-0172afa1	46	1	Kolkata	Kolkata	NNP
cord-334391-0172afa1	46	2	,	,	,
cord-334391-0172afa1	46	3	India	India	NNP
cord-334391-0172afa1	46	4	 	 	_SP
cord-334391-0172afa1	46	5	Ready	Ready	NNP
cord-334391-0172afa1	46	6	to	to	TO
cord-334391-0172afa1	46	7	submit	submit	VB
cord-334391-0172afa1	46	8	your	-PRON-	PRP$
cord-334391-0172afa1	46	9	research	research	NN
cord-334391-0172afa1	46	10	Ready	ready	JJ
cord-334391-0172afa1	46	11	to	to	TO
cord-334391-0172afa1	46	12	submit	submit	VB
cord-334391-0172afa1	46	13	your	-PRON-	PRP$
cord-334391-0172afa1	46	14	research	research	NN
cord-334391-0172afa1	46	15	?	?	.
cord-334391-0172afa1	47	1	Choose	choose	VB
cord-334391-0172afa1	47	2	BMC	BMC	NNP
cord-334391-0172afa1	47	3	and	and	CC
cord-334391-0172afa1	47	4	benefit	benefit	VB
cord-334391-0172afa1	47	5	from	from	IN
cord-334391-0172afa1	47	6	:	:	:
cord-334391-0172afa1	47	7	?	?	.
cord-334391-0172afa1	48	1	Choose	choose	VB
cord-334391-0172afa1	48	2	BMC	BMC	NNP
cord-334391-0172afa1	48	3	and	and	CC
cord-334391-0172afa1	48	4	benefit	benefit	VB
cord-334391-0172afa1	48	5	from	from	IN
cord-334391-0172afa1	48	6	:	:	:
cord-334391-0172afa1	48	7	Literature	literature	NN
cord-334391-0172afa1	48	8	survey	survey	NN
cord-334391-0172afa1	48	9	.	.	.
cord-334391-0172afa1	49	1	Not	not	RB
cord-334391-0172afa1	49	2	applicable	applicable	JJ
cord-334391-0172afa1	49	3	.	.	.
cord-334391-0172afa1	50	1	Yes	yes	UH
cord-334391-0172afa1	50	2	.	.	.
cord-334391-0172afa1	51	1	Competing	compete	VBG
cord-334391-0172afa1	51	2	interests	interest	NNS
cord-334391-0172afa1	52	1	I	-PRON-	PRP
cord-334391-0172afa1	52	2	do	do	VBP
cord-334391-0172afa1	52	3	not	not	RB
cord-334391-0172afa1	52	4	have	have	VB
cord-334391-0172afa1	52	5	any	any	DT
cord-334391-0172afa1	52	6	competing	compete	VBG
cord-334391-0172afa1	52	7	interests	interest	NNS
cord-334391-0172afa1	52	8	.	.	.
cord-334391-0172afa1	53	1	Received	receive	VBN
cord-334391-0172afa1	53	2	:	:	:
cord-334391-0172afa1	53	3	5	5	CD
cord-334391-0172afa1	53	4	October	October	NNP
cord-334391-0172afa1	53	5	2020	2020	CD
cord-334391-0172afa1	54	1	Accepted	accept	VBN
cord-334391-0172afa1	54	2	:	:	:
cord-334391-0172afa1	54	3	8	8	CD
cord-334391-0172afa1	54	4	October	October	NNP
cord-334391-0172afa1	54	5	2020	2020	CD