id sid tid token lemma pos cord-333986-xkx181ek 1 1 key key NN cord-333986-xkx181ek 1 2 : : : cord-333986-xkx181ek 1 3 cord-333986-xkx181ek cord-333986-xkx181ek NNP cord-333986-xkx181ek 1 4 authors author NNS cord-333986-xkx181ek 1 5 : : : cord-333986-xkx181ek 1 6 Hall Hall NNP cord-333986-xkx181ek 1 7 , , , cord-333986-xkx181ek 1 8 Mary Mary NNP cord-333986-xkx181ek 1 9 - - HYPH cord-333986-xkx181ek 1 10 Frances Frances NNP cord-333986-xkx181ek 1 11 E. E. NNP cord-333986-xkx181ek 1 12 ; ; : cord-333986-xkx181ek 1 13 Church Church NNP cord-333986-xkx181ek 1 14 , , , cord-333986-xkx181ek 1 15 Frank Frank NNP cord-333986-xkx181ek 1 16 C. C. NNP cord-333986-xkx181ek 2 1 title title NN cord-333986-xkx181ek 2 2 : : : cord-333986-xkx181ek 3 1 Exercise exercise VB cord-333986-xkx181ek 3 2 for for IN cord-333986-xkx181ek 3 3 Older old JJR cord-333986-xkx181ek 3 4 Adults Adults NNPS cord-333986-xkx181ek 3 5 Improves improve VBZ cord-333986-xkx181ek 3 6 the the DT cord-333986-xkx181ek 3 7 Quality Quality NNP cord-333986-xkx181ek 3 8 of of IN cord-333986-xkx181ek 3 9 Life Life NNP cord-333986-xkx181ek 3 10 in in IN cord-333986-xkx181ek 3 11 Parkinson Parkinson NNP cord-333986-xkx181ek 3 12 ’s ’s POS cord-333986-xkx181ek 3 13 Disease Disease NNP cord-333986-xkx181ek 3 14 and and CC cord-333986-xkx181ek 3 15 Potentially potentially RB cord-333986-xkx181ek 3 16 Enhances enhance VBZ cord-333986-xkx181ek 3 17 the the DT cord-333986-xkx181ek 3 18 Immune Immune NNP cord-333986-xkx181ek 3 19 Response response NN cord-333986-xkx181ek 3 20 to to IN cord-333986-xkx181ek 3 21 COVID-19 covid-19 JJ cord-333986-xkx181ek 3 22 date date NN cord-333986-xkx181ek 4 1 : : : cord-333986-xkx181ek 4 2 2020 2020 CD cord-333986-xkx181ek 4 3 - - HYPH cord-333986-xkx181ek 4 4 09 09 CD cord-333986-xkx181ek 4 5 - - HYPH cord-333986-xkx181ek 4 6 06 06 CD cord-333986-xkx181ek 4 7 journal journal NN cord-333986-xkx181ek 4 8 : : : cord-333986-xkx181ek 5 1 Brain Brain NNP cord-333986-xkx181ek 5 2 Sci Sci NNP cord-333986-xkx181ek 5 3 DOI DOI NNP cord-333986-xkx181ek 5 4 : : : cord-333986-xkx181ek 6 1 10.3390 10.3390 CD cord-333986-xkx181ek 6 2 / / SYM cord-333986-xkx181ek 6 3 brainsci10090612 brainsci10090612 NNP cord-333986-xkx181ek 6 4 sha sha NNP cord-333986-xkx181ek 6 5 : : : cord-333986-xkx181ek 6 6 621364fac10984daad325693b5eeb2adf25bb6b9 621364fac10984daad325693b5eeb2adf25bb6b9 CD cord-333986-xkx181ek 6 7 doc_id doc_id CD cord-333986-xkx181ek 6 8 : : : cord-333986-xkx181ek 6 9 333986 333986 CD cord-333986-xkx181ek 6 10 cord_uid cord_uid NNS cord-333986-xkx181ek 6 11 : : : cord-333986-xkx181ek 7 1 xkx181ek xkx181ek NNP cord-333986-xkx181ek 7 2 Parkinson Parkinson NNP cord-333986-xkx181ek 7 3 ’s ’s POS cord-333986-xkx181ek 7 4 disease disease NN cord-333986-xkx181ek 7 5 ( ( -LRB- cord-333986-xkx181ek 7 6 PD PD NNP cord-333986-xkx181ek 7 7 ) ) -RRB- cord-333986-xkx181ek 7 8 is be VBZ cord-333986-xkx181ek 7 9 a a DT cord-333986-xkx181ek 7 10 progressive progressive JJ cord-333986-xkx181ek 7 11 neurodegenerative neurodegenerative JJ cord-333986-xkx181ek 7 12 disorder disorder NN cord-333986-xkx181ek 7 13 brought bring VBN cord-333986-xkx181ek 7 14 about about RP cord-333986-xkx181ek 7 15 due due IN cord-333986-xkx181ek 7 16 to to IN cord-333986-xkx181ek 7 17 dopaminergic dopaminergic JJ cord-333986-xkx181ek 7 18 neuronal neuronal JJ cord-333986-xkx181ek 7 19 cell cell NN cord-333986-xkx181ek 7 20 loss loss NN cord-333986-xkx181ek 7 21 in in IN cord-333986-xkx181ek 7 22 the the DT cord-333986-xkx181ek 7 23 midbrain midbrain NN cord-333986-xkx181ek 7 24 substantia substantia NNP cord-333986-xkx181ek 7 25 nigra nigra NNP cord-333986-xkx181ek 7 26 pars pars NNP cord-333986-xkx181ek 7 27 compacta compacta NN cord-333986-xkx181ek 7 28 region region NN cord-333986-xkx181ek 7 29 . . . cord-333986-xkx181ek 8 1 PD PD NNP cord-333986-xkx181ek 8 2 presents present VBZ cord-333986-xkx181ek 8 3 most most RBS cord-333986-xkx181ek 8 4 commonly commonly RB cord-333986-xkx181ek 8 5 in in IN cord-333986-xkx181ek 8 6 older old JJR cord-333986-xkx181ek 8 7 adults adult NNS cord-333986-xkx181ek 8 8 and and CC cord-333986-xkx181ek 8 9 is be VBZ cord-333986-xkx181ek 8 10 a a DT cord-333986-xkx181ek 8 11 disorder disorder NN cord-333986-xkx181ek 8 12 of of IN cord-333986-xkx181ek 8 13 both both DT cord-333986-xkx181ek 8 14 motor motor NN cord-333986-xkx181ek 8 15 and and CC cord-333986-xkx181ek 8 16 nonmotor nonmotor NNP cord-333986-xkx181ek 8 17 dysfunction dysfunction NNP cord-333986-xkx181ek 8 18 . . . cord-333986-xkx181ek 9 1 The the DT cord-333986-xkx181ek 9 2 novel novel JJ cord-333986-xkx181ek 9 3 SARS SARS NNP cord-333986-xkx181ek 9 4 - - HYPH cord-333986-xkx181ek 9 5 CoV-2 CoV-2 NNP cord-333986-xkx181ek 9 6 virus virus NN cord-333986-xkx181ek 9 7 is be VBZ cord-333986-xkx181ek 9 8 responsible responsible JJ cord-333986-xkx181ek 9 9 for for IN cord-333986-xkx181ek 9 10 the the DT cord-333986-xkx181ek 9 11 recent recent JJ cord-333986-xkx181ek 9 12 COVID-19 COVID-19 NNP cord-333986-xkx181ek 9 13 pandemic pandemic NN cord-333986-xkx181ek 9 14 , , , cord-333986-xkx181ek 9 15 and and CC cord-333986-xkx181ek 9 16 older old JJR cord-333986-xkx181ek 9 17 individuals individual NNS cord-333986-xkx181ek 9 18 , , , cord-333986-xkx181ek 9 19 those those DT cord-333986-xkx181ek 9 20 with with IN cord-333986-xkx181ek 9 21 preexisting preexisting JJ cord-333986-xkx181ek 9 22 medical medical JJ cord-333986-xkx181ek 9 23 conditions condition NNS cord-333986-xkx181ek 9 24 , , , cord-333986-xkx181ek 9 25 or or CC cord-333986-xkx181ek 9 26 both both DT cord-333986-xkx181ek 9 27 have have VBP cord-333986-xkx181ek 9 28 an an DT cord-333986-xkx181ek 9 29 increased increase VBN cord-333986-xkx181ek 9 30 risk risk NN cord-333986-xkx181ek 9 31 of of IN cord-333986-xkx181ek 9 32 developing develop VBG cord-333986-xkx181ek 9 33 COVID-19 COVID-19 , cord-333986-xkx181ek 9 34 with with IN cord-333986-xkx181ek 9 35 more more JJR cord-333986-xkx181ek 9 36 severe severe JJ cord-333986-xkx181ek 9 37 outcomes outcome NNS cord-333986-xkx181ek 9 38 . . . cord-333986-xkx181ek 10 1 People People NNS cord-333986-xkx181ek 10 2 - - HYPH cord-333986-xkx181ek 10 3 with with IN cord-333986-xkx181ek 10 4 - - HYPH cord-333986-xkx181ek 10 5 Parkinson Parkinson NNP cord-333986-xkx181ek 10 6 ’s ’s POS cord-333986-xkx181ek 10 7 ( ( -LRB- cord-333986-xkx181ek 10 8 PwP PwP NNP cord-333986-xkx181ek 10 9 ) ) -RRB- cord-333986-xkx181ek 10 10 of of IN cord-333986-xkx181ek 10 11 advanced advanced JJ cord-333986-xkx181ek 10 12 age age NN cord-333986-xkx181ek 10 13 can can MD cord-333986-xkx181ek 10 14 have have VB cord-333986-xkx181ek 10 15 both both DT cord-333986-xkx181ek 10 16 immune immune JJ cord-333986-xkx181ek 10 17 and and CC cord-333986-xkx181ek 10 18 autonomic autonomic JJ cord-333986-xkx181ek 10 19 nervous nervous JJ cord-333986-xkx181ek 10 20 problems problem NNS cord-333986-xkx181ek 10 21 that that WDT cord-333986-xkx181ek 10 22 potentially potentially RB cord-333986-xkx181ek 10 23 lead lead VBP cord-333986-xkx181ek 10 24 to to TO cord-333986-xkx181ek 10 25 pre pre VB cord-333986-xkx181ek 10 26 - - JJ cord-333986-xkx181ek 10 27 existing existing JJ cord-333986-xkx181ek 10 28 pulmonary pulmonary JJ cord-333986-xkx181ek 10 29 dysfunction dysfunction NN cord-333986-xkx181ek 10 30 and and CC cord-333986-xkx181ek 10 31 higher high JJR cord-333986-xkx181ek 10 32 infection infection NN cord-333986-xkx181ek 10 33 risk risk NN cord-333986-xkx181ek 10 34 , , , cord-333986-xkx181ek 10 35 increasing increase VBG cord-333986-xkx181ek 10 36 the the DT cord-333986-xkx181ek 10 37 probability probability NN cord-333986-xkx181ek 10 38 of of IN cord-333986-xkx181ek 10 39 contracting contracting NN cord-333986-xkx181ek 10 40 COVID-19 covid-19 NN cord-333986-xkx181ek 10 41 . . . cord-333986-xkx181ek 11 1 A a DT cord-333986-xkx181ek 11 2 lifestyle lifestyle NN cord-333986-xkx181ek 11 3 change change NN cord-333986-xkx181ek 11 4 involving involve VBG cord-333986-xkx181ek 11 5 moderate moderate JJ cord-333986-xkx181ek 11 6 - - HYPH cord-333986-xkx181ek 11 7 intensity intensity NN cord-333986-xkx181ek 11 8 exercise exercise NN cord-333986-xkx181ek 11 9 has have VBZ cord-333986-xkx181ek 11 10 the the DT cord-333986-xkx181ek 11 11 potential potential NN cord-333986-xkx181ek 11 12 to to TO cord-333986-xkx181ek 11 13 protect protect VB cord-333986-xkx181ek 11 14 against against IN cord-333986-xkx181ek 11 15 SARS SARS NNP cord-333986-xkx181ek 11 16 - - : cord-333986-xkx181ek 11 17 CoV-2 CoV-2 NNP cord-333986-xkx181ek 11 18 through through IN cord-333986-xkx181ek 11 19 strengthening strengthen VBG cord-333986-xkx181ek 11 20 the the DT cord-333986-xkx181ek 11 21 immune immune JJ cord-333986-xkx181ek 11 22 system system NN cord-333986-xkx181ek 11 23 . . . cord-333986-xkx181ek 12 1 In in IN cord-333986-xkx181ek 12 2 addition addition NN cord-333986-xkx181ek 12 3 to to IN cord-333986-xkx181ek 12 4 a a DT cord-333986-xkx181ek 12 5 potential potential JJ cord-333986-xkx181ek 12 6 protective protective JJ cord-333986-xkx181ek 12 7 measure measure NN cord-333986-xkx181ek 12 8 against against IN cord-333986-xkx181ek 12 9 SARS SARS NNP cord-333986-xkx181ek 12 10 - - HYPH cord-333986-xkx181ek 12 11 CoV-2 CoV-2 NNP cord-333986-xkx181ek 12 12 , , , cord-333986-xkx181ek 12 13 exercise exercise NN cord-333986-xkx181ek 12 14 has have VBZ cord-333986-xkx181ek 12 15 been be VBN cord-333986-xkx181ek 12 16 shown show VBN cord-333986-xkx181ek 12 17 to to TO cord-333986-xkx181ek 12 18 improve improve VB cord-333986-xkx181ek 12 19 quality quality NN cord-333986-xkx181ek 12 20 - - HYPH cord-333986-xkx181ek 12 21 of of IN cord-333986-xkx181ek 12 22 - - HYPH cord-333986-xkx181ek 12 23 life life NN cord-333986-xkx181ek 12 24 ( ( -LRB- cord-333986-xkx181ek 12 25 QoL qol NN cord-333986-xkx181ek 12 26 ) ) -RRB- cord-333986-xkx181ek 12 27 in in IN cord-333986-xkx181ek 12 28 PD PD NNP cord-333986-xkx181ek 12 29 patients patient NNS cord-333986-xkx181ek 12 30 . . . cord-333986-xkx181ek 13 1 Recent recent JJ cord-333986-xkx181ek 13 2 studies study NNS cord-333986-xkx181ek 13 3 provide provide VBP cord-333986-xkx181ek 13 4 evidence evidence NN cord-333986-xkx181ek 13 5 of of IN cord-333986-xkx181ek 13 6 exercise exercise NN cord-333986-xkx181ek 13 7 as as IN cord-333986-xkx181ek 13 8 both both DT cord-333986-xkx181ek 13 9 neuroprotective neuroprotective JJ cord-333986-xkx181ek 13 10 and and CC cord-333986-xkx181ek 13 11 neuroplastic neuroplastic JJ cord-333986-xkx181ek 13 12 . . . cord-333986-xkx181ek 14 1 This this DT cord-333986-xkx181ek 14 2 article article NN cord-333986-xkx181ek 14 3 is be VBZ cord-333986-xkx181ek 14 4 a a DT cord-333986-xkx181ek 14 5 literature literature NN cord-333986-xkx181ek 14 6 review review NN cord-333986-xkx181ek 14 7 investigating investigate VBG cord-333986-xkx181ek 14 8 the the DT cord-333986-xkx181ek 14 9 role role NN cord-333986-xkx181ek 14 10 exercise exercise NN cord-333986-xkx181ek 14 11 plays play VBZ cord-333986-xkx181ek 14 12 in in IN cord-333986-xkx181ek 14 13 modifying modify VBG cord-333986-xkx181ek 14 14 the the DT cord-333986-xkx181ek 14 15 immune immune JJ cord-333986-xkx181ek 14 16 system system NN cord-333986-xkx181ek 14 17 , , , cord-333986-xkx181ek 14 18 improving improve VBG cord-333986-xkx181ek 14 19 health health NN cord-333986-xkx181ek 14 20 outcomes outcome NNS cord-333986-xkx181ek 14 21 in in IN cord-333986-xkx181ek 14 22 PwP pwp NN cord-333986-xkx181ek 14 23 , , , cord-333986-xkx181ek 14 24 and and CC cord-333986-xkx181ek 14 25 potentially potentially RB cord-333986-xkx181ek 14 26 acting act VBG cord-333986-xkx181ek 14 27 as as IN cord-333986-xkx181ek 14 28 a a DT cord-333986-xkx181ek 14 29 protective protective JJ cord-333986-xkx181ek 14 30 measure measure NN cord-333986-xkx181ek 14 31 against against IN cord-333986-xkx181ek 14 32 SARS SARS NNP cord-333986-xkx181ek 14 33 - - HYPH cord-333986-xkx181ek 14 34 Cov-2 Cov-2 NNP cord-333986-xkx181ek 14 35 infection infection NN cord-333986-xkx181ek 14 36 . . . cord-333986-xkx181ek 15 1 We -PRON- PRP cord-333986-xkx181ek 15 2 conclude conclude VBP cord-333986-xkx181ek 15 3 that that DT cord-333986-xkx181ek 15 4 exercise exercise NN cord-333986-xkx181ek 15 5 , , , cord-333986-xkx181ek 15 6 when when WRB cord-333986-xkx181ek 15 7 correctly correctly RB cord-333986-xkx181ek 15 8 performed perform VBN cord-333986-xkx181ek 15 9 , , , cord-333986-xkx181ek 15 10 improves improve VBZ cord-333986-xkx181ek 15 11 QoL qol NN cord-333986-xkx181ek 15 12 and and CC cord-333986-xkx181ek 15 13 outcomes outcome NNS cord-333986-xkx181ek 15 14 in in IN cord-333986-xkx181ek 15 15 PwP pwp NN cord-333986-xkx181ek 15 16 , , , cord-333986-xkx181ek 15 17 and and CC cord-333986-xkx181ek 15 18 that that IN cord-333986-xkx181ek 15 19 the the DT cord-333986-xkx181ek 15 20 enhanced enhance VBN cord-333986-xkx181ek 15 21 immune immune JJ cord-333986-xkx181ek 15 22 response response NN cord-333986-xkx181ek 15 23 from from IN cord-333986-xkx181ek 15 24 moderate moderate JJ cord-333986-xkx181ek 15 25 - - HYPH cord-333986-xkx181ek 15 26 intensity intensity NN cord-333986-xkx181ek 15 27 exercise exercise NN cord-333986-xkx181ek 15 28 could could MD cord-333986-xkx181ek 15 29 potentially potentially RB cord-333986-xkx181ek 15 30 offer offer VB cord-333986-xkx181ek 15 31 additional additional JJ cord-333986-xkx181ek 15 32 protection protection NN cord-333986-xkx181ek 15 33 against against IN cord-333986-xkx181ek 15 34 COVID-19 COVID-19 NNP cord-333986-xkx181ek 15 35 . . . cord-333986-xkx181ek 16 1 There there EX cord-333986-xkx181ek 16 2 is be VBZ cord-333986-xkx181ek 16 3 evidence evidence NN cord-333986-xkx181ek 16 4 for for IN cord-333986-xkx181ek 16 5 two two CD cord-333986-xkx181ek 16 6 groups group NNS cord-333986-xkx181ek 16 7 of of IN cord-333986-xkx181ek 16 8 people people NNS cord-333986-xkx181ek 16 9 who who WP cord-333986-xkx181ek 16 10 will will MD cord-333986-xkx181ek 16 11 likely likely RB cord-333986-xkx181ek 16 12 have have VB cord-333986-xkx181ek 16 13 worse bad JJR cord-333986-xkx181ek 16 14 outcomes outcome NNS cord-333986-xkx181ek 16 15 following follow VBG cord-333986-xkx181ek 16 16 COVID-19 covid-19 JJ cord-333986-xkx181ek 16 17 infection infection NN cord-333986-xkx181ek 16 18 . . . cord-333986-xkx181ek 17 1 These these DT cord-333986-xkx181ek 17 2 include include VBP cord-333986-xkx181ek 17 3 older old JJR cord-333986-xkx181ek 17 4 adults adult NNS cord-333986-xkx181ek 17 5 and and CC cord-333986-xkx181ek 17 6 those those DT cord-333986-xkx181ek 17 7 with with IN cord-333986-xkx181ek 17 8 pre pre JJ cord-333986-xkx181ek 17 9 - - JJ cord-333986-xkx181ek 17 10 existing existing JJ cord-333986-xkx181ek 17 11 medical medical JJ cord-333986-xkx181ek 17 12 conditions condition NNS cord-333986-xkx181ek 17 13 ( ( -LRB- cord-333986-xkx181ek 17 14 chronic chronic JJ cord-333986-xkx181ek 17 15 kidney kidney NN cord-333986-xkx181ek 17 16 disease disease NN cord-333986-xkx181ek 17 17 , , , cord-333986-xkx181ek 17 18 chronic chronic JJ cord-333986-xkx181ek 17 19 obstructive obstructive JJ cord-333986-xkx181ek 17 20 pulmonary pulmonary JJ cord-333986-xkx181ek 17 21 disease disease NN cord-333986-xkx181ek 17 22 , , , cord-333986-xkx181ek 17 23 obesity obesity NN cord-333986-xkx181ek 17 24 , , , cord-333986-xkx181ek 17 25 serious serious JJ cord-333986-xkx181ek 17 26 cardiovascular cardiovascular JJ cord-333986-xkx181ek 17 27 disease disease NN cord-333986-xkx181ek 17 28 , , , cord-333986-xkx181ek 17 29 severe severe JJ cord-333986-xkx181ek 17 30 immunocompromised immunocompromised JJ cord-333986-xkx181ek 17 31 state state NN cord-333986-xkx181ek 17 32 , , , cord-333986-xkx181ek 17 33 type type NN cord-333986-xkx181ek 17 34 2 2 CD cord-333986-xkx181ek 17 35 diabetes diabetes NN cord-333986-xkx181ek 17 36 , , , cord-333986-xkx181ek 17 37 sickle sickle NN cord-333986-xkx181ek 17 38 cell cell NN cord-333986-xkx181ek 17 39 anemia anemia NN cord-333986-xkx181ek 17 40 , , , cord-333986-xkx181ek 17 41 and and CC cord-333986-xkx181ek 17 42 frailty frailty NN cord-333986-xkx181ek 17 43 ) ) -RRB- cord-333986-xkx181ek 17 44 , , , cord-333986-xkx181ek 17 45 or or CC cord-333986-xkx181ek 17 46 both both DT cord-333986-xkx181ek 17 47 [ [ -LRB- cord-333986-xkx181ek 17 48 32 32 CD cord-333986-xkx181ek 17 49 ] ] -RRB- cord-333986-xkx181ek 17 50 [ [ -LRB- cord-333986-xkx181ek 17 51 33 33 CD cord-333986-xkx181ek 17 52 ] ] -RRB- cord-333986-xkx181ek 17 53 [ [ -LRB- cord-333986-xkx181ek 17 54 34 34 CD cord-333986-xkx181ek 17 55 ] ] -RRB- cord-333986-xkx181ek 17 56 [ [ -LRB- cord-333986-xkx181ek 17 57 35 35 CD cord-333986-xkx181ek 17 58 ] ] -RRB- cord-333986-xkx181ek 17 59 [ [ -LRB- cord-333986-xkx181ek 17 60 36 36 CD cord-333986-xkx181ek 17 61 ] ] -RRB- cord-333986-xkx181ek 17 62 [ [ -LRB- cord-333986-xkx181ek 17 63 37 37 CD cord-333986-xkx181ek 17 64 ] ] -RRB- cord-333986-xkx181ek 17 65 . . . cord-333986-xkx181ek 18 1 An an DT cord-333986-xkx181ek 18 2 additional additional JJ cord-333986-xkx181ek 18 3 possibility possibility NN cord-333986-xkx181ek 18 4 is be VBZ cord-333986-xkx181ek 18 5 that that IN cord-333986-xkx181ek 18 6 people people NNS cord-333986-xkx181ek 18 7 - - HYPH cord-333986-xkx181ek 18 8 with with IN cord-333986-xkx181ek 18 9 - - HYPH cord-333986-xkx181ek 18 10 Parkinson Parkinson NNP cord-333986-xkx181ek 18 11 's 's POS cord-333986-xkx181ek 18 12 ( ( -LRB- cord-333986-xkx181ek 18 13 PwP PwP NNP cord-333986-xkx181ek 18 14 ) ) -RRB- cord-333986-xkx181ek 18 15 would would MD cord-333986-xkx181ek 18 16 be be VB cord-333986-xkx181ek 18 17 at at IN cord-333986-xkx181ek 18 18 increased increase VBN cord-333986-xkx181ek 18 19 risk risk NN cord-333986-xkx181ek 18 20 of of IN cord-333986-xkx181ek 18 21 worse bad JJR cord-333986-xkx181ek 18 22 outcomes outcome NNS cord-333986-xkx181ek 18 23 from from IN cord-333986-xkx181ek 18 24 COVID-19 COVID-19 NNP cord-333986-xkx181ek 18 25 since since IN cord-333986-xkx181ek 18 26 PD PD NNP cord-333986-xkx181ek 18 27 is be VBZ cord-333986-xkx181ek 18 28 more more RBR cord-333986-xkx181ek 18 29 common common JJ cord-333986-xkx181ek 18 30 in in IN cord-333986-xkx181ek 18 31 older old JJR cord-333986-xkx181ek 18 32 adults adult NNS cord-333986-xkx181ek 18 33 , , , cord-333986-xkx181ek 18 34 and and CC cord-333986-xkx181ek 18 35 PwP pwp NN cord-333986-xkx181ek 18 36 can can MD cord-333986-xkx181ek 18 37 have have VB cord-333986-xkx181ek 18 38 compromised compromise VBN cord-333986-xkx181ek 18 39 respiratory respiratory JJ cord-333986-xkx181ek 18 40 and and CC cord-333986-xkx181ek 18 41 immune immune JJ cord-333986-xkx181ek 18 42 states state NNS cord-333986-xkx181ek 18 43 [ [ -LRB- cord-333986-xkx181ek 18 44 38 38 CD cord-333986-xkx181ek 18 45 ] ] -RRB- cord-333986-xkx181ek 18 46 [ [ -LRB- cord-333986-xkx181ek 18 47 39 39 CD cord-333986-xkx181ek 18 48 ] ] -RRB- cord-333986-xkx181ek 18 49 [ [ -LRB- cord-333986-xkx181ek 18 50 40 40 CD cord-333986-xkx181ek 18 51 ] ] -RRB- cord-333986-xkx181ek 18 52 . . . cord-333986-xkx181ek 19 1 In in IN cord-333986-xkx181ek 19 2 just just RB cord-333986-xkx181ek 19 3 a a DT cord-333986-xkx181ek 19 4 few few JJ cord-333986-xkx181ek 19 5 months month NNS cord-333986-xkx181ek 19 6 , , , cord-333986-xkx181ek 19 7 we -PRON- PRP cord-333986-xkx181ek 19 8 have have VBP cord-333986-xkx181ek 19 9 gained gain VBN cord-333986-xkx181ek 19 10 a a DT cord-333986-xkx181ek 19 11 tremendous tremendous JJ cord-333986-xkx181ek 19 12 amount amount NN cord-333986-xkx181ek 19 13 of of IN cord-333986-xkx181ek 19 14 understanding understanding NN cord-333986-xkx181ek 19 15 regarding regard VBG cord-333986-xkx181ek 19 16 COVID-19 COVID-19 NNP cord-333986-xkx181ek 19 17 . . . cord-333986-xkx181ek 20 1 While while IN cord-333986-xkx181ek 20 2 significant significant JJ cord-333986-xkx181ek 20 3 effort effort NN cord-333986-xkx181ek 20 4 is be VBZ cord-333986-xkx181ek 20 5 focused focus VBN cord-333986-xkx181ek 20 6 on on IN cord-333986-xkx181ek 20 7 finding find VBG cord-333986-xkx181ek 20 8 either either CC cord-333986-xkx181ek 20 9 a a DT cord-333986-xkx181ek 20 10 cure cure NN cord-333986-xkx181ek 20 11 or or CC cord-333986-xkx181ek 20 12 effective effective JJ cord-333986-xkx181ek 20 13 therapies therapy NNS cord-333986-xkx181ek 20 14 for for IN cord-333986-xkx181ek 20 15 COVID-19 COVID-19 NNP cord-333986-xkx181ek 20 16 , , , cord-333986-xkx181ek 20 17 to to IN cord-333986-xkx181ek 20 18 date date NN cord-333986-xkx181ek 20 19 , , , cord-333986-xkx181ek 20 20 treatment treatment NN cord-333986-xkx181ek 20 21 is be VBZ cord-333986-xkx181ek 20 22 primarily primarily RB cord-333986-xkx181ek 20 23 supportive supportive JJ cord-333986-xkx181ek 20 24 , , , cord-333986-xkx181ek 20 25 and and CC cord-333986-xkx181ek 20 26 the the DT cord-333986-xkx181ek 20 27 role role NN cord-333986-xkx181ek 20 28 of of IN cord-333986-xkx181ek 20 29 antiviral antiviral JJ cord-333986-xkx181ek 20 30 protection protection NN cord-333986-xkx181ek 20 31 remains remain VBZ cord-333986-xkx181ek 20 32 in in IN cord-333986-xkx181ek 20 33 testing testing NN cord-333986-xkx181ek 20 34 . . . cord-333986-xkx181ek 21 1 The the DT cord-333986-xkx181ek 21 2 lack lack NN cord-333986-xkx181ek 21 3 of of IN cord-333986-xkx181ek 21 4 treatment treatment NN cord-333986-xkx181ek 21 5 options option NNS cord-333986-xkx181ek 21 6 leads lead VBZ cord-333986-xkx181ek 21 7 to to TO cord-333986-xkx181ek 21 8 pressure pressure NN cord-333986-xkx181ek 21 9 to to TO cord-333986-xkx181ek 21 10 find find VB cord-333986-xkx181ek 21 11 other other JJ cord-333986-xkx181ek 21 12 ways way NNS cord-333986-xkx181ek 21 13 to to TO cord-333986-xkx181ek 21 14 combat combat VB cord-333986-xkx181ek 21 15 an an DT cord-333986-xkx181ek 21 16 infection infection NN cord-333986-xkx181ek 21 17 that that WDT cord-333986-xkx181ek 21 18 disproportionately disproportionately RB cord-333986-xkx181ek 21 19 affects affect VBZ cord-333986-xkx181ek 21 20 older old JJR cord-333986-xkx181ek 21 21 adults adult NNS cord-333986-xkx181ek 21 22 , , , cord-333986-xkx181ek 21 23 the the DT cord-333986-xkx181ek 21 24 immunocompromised immunocompromised JJ cord-333986-xkx181ek 21 25 , , , cord-333986-xkx181ek 21 26 and and CC cord-333986-xkx181ek 21 27 those those DT cord-333986-xkx181ek 21 28 with with IN cord-333986-xkx181ek 21 29 pre pre JJ cord-333986-xkx181ek 21 30 - - JJ cord-333986-xkx181ek 21 31 existing existing JJ cord-333986-xkx181ek 21 32 medical medical JJ cord-333986-xkx181ek 21 33 conditions condition NNS cord-333986-xkx181ek 21 34 . . . cord-333986-xkx181ek 22 1 Recently recently RB cord-333986-xkx181ek 22 2 , , , cord-333986-xkx181ek 22 3 we -PRON- PRP cord-333986-xkx181ek 22 4 suggested suggest VBD cord-333986-xkx181ek 22 5 that that IN cord-333986-xkx181ek 22 6 vitamin vitamin NN cord-333986-xkx181ek 22 7 D D NNP cord-333986-xkx181ek 22 8 3 3 CD cord-333986-xkx181ek 22 9 was be VBD cord-333986-xkx181ek 22 10 a a DT cord-333986-xkx181ek 22 11 feasible feasible JJ cord-333986-xkx181ek 22 12 option option NN cord-333986-xkx181ek 22 13 [ [ -LRB- cord-333986-xkx181ek 22 14 41 41 CD cord-333986-xkx181ek 22 15 ] ] -RRB- cord-333986-xkx181ek 22 16 . . . cord-333986-xkx181ek 23 1 Another another DT cord-333986-xkx181ek 23 2 possible possible JJ cord-333986-xkx181ek 23 3 option option NN cord-333986-xkx181ek 23 4 is be VBZ cord-333986-xkx181ek 23 5 exercise exercise NN cord-333986-xkx181ek 23 6 . . . cord-333986-xkx181ek 24 1 The the DT cord-333986-xkx181ek 24 2 goal goal NN cord-333986-xkx181ek 24 3 of of IN cord-333986-xkx181ek 24 4 this this DT cord-333986-xkx181ek 24 5 review review NN cord-333986-xkx181ek 24 6 is be VBZ cord-333986-xkx181ek 24 7 to to TO cord-333986-xkx181ek 24 8 outline outline VB cord-333986-xkx181ek 24 9 research research NN cord-333986-xkx181ek 24 10 elucidating elucidate VBG cord-333986-xkx181ek 24 11 the the DT cord-333986-xkx181ek 24 12 relationship relationship NN cord-333986-xkx181ek 24 13 between between IN cord-333986-xkx181ek 24 14 exercise exercise NN cord-333986-xkx181ek 24 15 and and CC cord-333986-xkx181ek 24 16 beneficial beneficial JJ cord-333986-xkx181ek 24 17 changes change NNS cord-333986-xkx181ek 24 18 in in IN cord-333986-xkx181ek 24 19 the the DT cord-333986-xkx181ek 24 20 immune immune JJ cord-333986-xkx181ek 24 21 system system NN cord-333986-xkx181ek 24 22 and and CC cord-333986-xkx181ek 24 23 then then RB cord-333986-xkx181ek 24 24 apply apply VB cord-333986-xkx181ek 24 25 this this DT cord-333986-xkx181ek 24 26 information information NN cord-333986-xkx181ek 24 27 to to TO cord-333986-xkx181ek 24 28 demonstrate demonstrate VB cord-333986-xkx181ek 24 29 how how WRB cord-333986-xkx181ek 24 30 exercise exercise NN cord-333986-xkx181ek 24 31 improves improve VBZ cord-333986-xkx181ek 24 32 QoL qol NN cord-333986-xkx181ek 24 33 and and CC cord-333986-xkx181ek 24 34 outcomes outcome NNS cord-333986-xkx181ek 24 35 in in IN cord-333986-xkx181ek 24 36 PD PD NNP cord-333986-xkx181ek 24 37 and and CC cord-333986-xkx181ek 24 38 possibly possibly RB cord-333986-xkx181ek 24 39 helps help VBZ cord-333986-xkx181ek 24 40 resist resist VB cord-333986-xkx181ek 24 41 COVID-19 covid-19 JJ cord-333986-xkx181ek 24 42 infection infection NN cord-333986-xkx181ek 25 1 ( ( -LRB- cord-333986-xkx181ek 25 2 Figure figure NN cord-333986-xkx181ek 25 3 1 1 CD cord-333986-xkx181ek 25 4 ) ) -RRB- cord-333986-xkx181ek 25 5 . . . cord-333986-xkx181ek 26 1 Brain Brain NNP cord-333986-xkx181ek 26 2 Sci Sci NNP cord-333986-xkx181ek 26 3 . . . cord-333986-xkx181ek 27 1 2020 2020 CD cord-333986-xkx181ek 27 2 , , , cord-333986-xkx181ek 27 3 10 10 CD cord-333986-xkx181ek 27 4 , , , cord-333986-xkx181ek 28 1 x x NN cord-333986-xkx181ek 28 2 FOR for IN cord-333986-xkx181ek 28 3 PEER peer NN cord-333986-xkx181ek 28 4 REVIEW REVIEW NNP cord-333986-xkx181ek 28 5 2 2 CD cord-333986-xkx181ek 28 6 of of IN cord-333986-xkx181ek 28 7 19 19 CD cord-333986-xkx181ek 28 8 possible possible JJ cord-333986-xkx181ek 28 9 option option NN cord-333986-xkx181ek 28 10 is be VBZ cord-333986-xkx181ek 28 11 exercise exercise NN cord-333986-xkx181ek 28 12 . . . cord-333986-xkx181ek 29 1 The the DT cord-333986-xkx181ek 29 2 goal goal NN cord-333986-xkx181ek 29 3 of of IN cord-333986-xkx181ek 29 4 this this DT cord-333986-xkx181ek 29 5 review review NN cord-333986-xkx181ek 29 6 is be VBZ cord-333986-xkx181ek 29 7 to to TO cord-333986-xkx181ek 29 8 outline outline VB cord-333986-xkx181ek 29 9 research research NN cord-333986-xkx181ek 29 10 elucidating elucidate VBG cord-333986-xkx181ek 29 11 the the DT cord-333986-xkx181ek 29 12 relationship relationship NN cord-333986-xkx181ek 29 13 between between IN cord-333986-xkx181ek 29 14 exercise exercise NN cord-333986-xkx181ek 29 15 and and CC cord-333986-xkx181ek 29 16 beneficial beneficial JJ cord-333986-xkx181ek 29 17 changes change NNS cord-333986-xkx181ek 29 18 in in IN cord-333986-xkx181ek 29 19 the the DT cord-333986-xkx181ek 29 20 immune immune JJ cord-333986-xkx181ek 29 21 system system NN cord-333986-xkx181ek 29 22 and and CC cord-333986-xkx181ek 29 23 then then RB cord-333986-xkx181ek 29 24 apply apply VB cord-333986-xkx181ek 29 25 this this DT cord-333986-xkx181ek 29 26 information information NN cord-333986-xkx181ek 29 27 to to TO cord-333986-xkx181ek 29 28 demonstrate demonstrate VB cord-333986-xkx181ek 29 29 how how WRB cord-333986-xkx181ek 29 30 exercise exercise NN cord-333986-xkx181ek 29 31 improves improve VBZ cord-333986-xkx181ek 29 32 QoL qol NN cord-333986-xkx181ek 29 33 and and CC cord-333986-xkx181ek 29 34 outcomes outcome NNS cord-333986-xkx181ek 29 35 in in IN cord-333986-xkx181ek 29 36 PD PD NNP cord-333986-xkx181ek 29 37 and and CC cord-333986-xkx181ek 29 38 possibly possibly RB cord-333986-xkx181ek 29 39 helps help VBZ cord-333986-xkx181ek 29 40 resist resist VB cord-333986-xkx181ek 29 41 COVID-19 covid-19 JJ cord-333986-xkx181ek 29 42 infection infection NN cord-333986-xkx181ek 30 1 ( ( -LRB- cord-333986-xkx181ek 30 2 Figure figure NN cord-333986-xkx181ek 30 3 1 1 CD cord-333986-xkx181ek 30 4 ) ) -RRB- cord-333986-xkx181ek 30 5 . . . cord-333986-xkx181ek 31 1 Juvenal Juvenal NNP cord-333986-xkx181ek 31 2 's 's POS cord-333986-xkx181ek 31 3 centuries century NNS cord-333986-xkx181ek 31 4 - - HYPH cord-333986-xkx181ek 31 5 old old JJ cord-333986-xkx181ek 31 6 dictum dictum NN cord-333986-xkx181ek 31 7 to to TO cord-333986-xkx181ek 31 8 seek seek VB cord-333986-xkx181ek 31 9 a a DT cord-333986-xkx181ek 31 10 healthy healthy JJ cord-333986-xkx181ek 31 11 mind mind NN cord-333986-xkx181ek 31 12 in in IN cord-333986-xkx181ek 31 13 a a DT cord-333986-xkx181ek 31 14 healthy healthy JJ cord-333986-xkx181ek 31 15 body body NN cord-333986-xkx181ek 31 16 is be VBZ cord-333986-xkx181ek 31 17 from from IN cord-333986-xkx181ek 31 18 [ [ -LRB- cord-333986-xkx181ek 31 19 42 42 CD cord-333986-xkx181ek 31 20 ] ] -RRB- cord-333986-xkx181ek 31 21 . . . cord-333986-xkx181ek 32 1 Exercise exercise NN cord-333986-xkx181ek 32 2 is be VBZ cord-333986-xkx181ek 32 3 a a DT cord-333986-xkx181ek 32 4 physical physical JJ cord-333986-xkx181ek 32 5 activity activity NN cord-333986-xkx181ek 32 6 that that WDT cord-333986-xkx181ek 32 7 requires require VBZ cord-333986-xkx181ek 32 8 effort effort NN cord-333986-xkx181ek 32 9 , , , cord-333986-xkx181ek 32 10 and and CC cord-333986-xkx181ek 32 11 it -PRON- PRP cord-333986-xkx181ek 32 12 is be VBZ cord-333986-xkx181ek 32 13 usually usually RB cord-333986-xkx181ek 32 14 carried carry VBN cord-333986-xkx181ek 32 15 out out RP cord-333986-xkx181ek 32 16 to to TO cord-333986-xkx181ek 32 17 sustain sustain VB cord-333986-xkx181ek 32 18 or or CC cord-333986-xkx181ek 32 19 improve improve VB cord-333986-xkx181ek 32 20 health health NN cord-333986-xkx181ek 32 21 and and CC cord-333986-xkx181ek 32 22 fitness fitness NN cord-333986-xkx181ek 32 23 [ [ -LRB- cord-333986-xkx181ek 32 24 43 43 CD cord-333986-xkx181ek 32 25 , , , cord-333986-xkx181ek 32 26 44 44 CD cord-333986-xkx181ek 32 27 ] ] -RRB- cord-333986-xkx181ek 32 28 . . . cord-333986-xkx181ek 33 1 We -PRON- PRP cord-333986-xkx181ek 33 2 define define VBP cord-333986-xkx181ek 33 3 low low JJ cord-333986-xkx181ek 33 4 - - HYPH cord-333986-xkx181ek 33 5 intensity intensity NN cord-333986-xkx181ek 33 6 exercise exercise NN cord-333986-xkx181ek 33 7 as as IN cord-333986-xkx181ek 33 8 activity activity NN cord-333986-xkx181ek 33 9 that that WDT cord-333986-xkx181ek 33 10 increases increase VBZ cord-333986-xkx181ek 33 11 your -PRON- PRP$ cord-333986-xkx181ek 33 12 heart heart NN cord-333986-xkx181ek 33 13 rate rate NN cord-333986-xkx181ek 33 14 up up IN cord-333986-xkx181ek 33 15 to to TO cord-333986-xkx181ek 33 16 40 40 CD cord-333986-xkx181ek 33 17 - - SYM cord-333986-xkx181ek 33 18 50 50 CD cord-333986-xkx181ek 33 19 % % NN cord-333986-xkx181ek 33 20 of of IN cord-333986-xkx181ek 33 21 your -PRON- PRP$ cord-333986-xkx181ek 33 22 maximum maximum JJ cord-333986-xkx181ek 33 23 heart heart NN cord-333986-xkx181ek 33 24 rate rate NN cord-333986-xkx181ek 33 25 ( ( -LRB- cord-333986-xkx181ek 33 26 MHR MHR NNP cord-333986-xkx181ek 33 27 ) ) -RRB- cord-333986-xkx181ek 33 28 . . . cord-333986-xkx181ek 34 1 This this DT cord-333986-xkx181ek 34 2 would would MD cord-333986-xkx181ek 34 3 include include VB cord-333986-xkx181ek 34 4 a a DT cord-333986-xkx181ek 34 5 casual casual JJ cord-333986-xkx181ek 34 6 walk walk NN cord-333986-xkx181ek 34 7 with with IN cord-333986-xkx181ek 34 8 a a DT cord-333986-xkx181ek 34 9 pet pet JJ cord-333986-xkx181ek 34 10 dog dog NN cord-333986-xkx181ek 34 11 or or CC cord-333986-xkx181ek 34 12 walking walk VBG cord-333986-xkx181ek 34 13 up up RP cord-333986-xkx181ek 34 14 a a DT cord-333986-xkx181ek 34 15 few few JJ cord-333986-xkx181ek 34 16 flights flight NNS cord-333986-xkx181ek 34 17 of of IN cord-333986-xkx181ek 34 18 steps step NNS cord-333986-xkx181ek 34 19 instead instead RB cord-333986-xkx181ek 34 20 of of IN cord-333986-xkx181ek 34 21 taking take VBG cord-333986-xkx181ek 34 22 the the DT cord-333986-xkx181ek 34 23 elevator elevator NN cord-333986-xkx181ek 34 24 . . . cord-333986-xkx181ek 35 1 We -PRON- PRP cord-333986-xkx181ek 35 2 define define VBP cord-333986-xkx181ek 35 3 moderateintensity moderateintensity NN cord-333986-xkx181ek 35 4 ( ( -LRB- cord-333986-xkx181ek 35 5 or or CC cord-333986-xkx181ek 35 6 simply simply RB cord-333986-xkx181ek 35 7 moderate moderate JJ cord-333986-xkx181ek 35 8 ) ) -RRB- cord-333986-xkx181ek 35 9 exercise exercise NN cord-333986-xkx181ek 35 10 as as IN cord-333986-xkx181ek 35 11 physical physical JJ cord-333986-xkx181ek 35 12 activity activity NN cord-333986-xkx181ek 35 13 for for IN cord-333986-xkx181ek 35 14 ≤60 ≤60 NNP cord-333986-xkx181ek 35 15 min min NNP cord-333986-xkx181ek 35 16 that that WDT cord-333986-xkx181ek 35 17 increases increase VBZ cord-333986-xkx181ek 35 18 your -PRON- PRP$ cord-333986-xkx181ek 35 19 heart heart NN cord-333986-xkx181ek 35 20 rate rate NN cord-333986-xkx181ek 35 21 to to IN cord-333986-xkx181ek 35 22 50 50 CD cord-333986-xkx181ek 35 23 - - SYM cord-333986-xkx181ek 35 24 70 70 CD cord-333986-xkx181ek 35 25 % % NN cord-333986-xkx181ek 35 26 of of IN cord-333986-xkx181ek 35 27 your -PRON- PRP$ cord-333986-xkx181ek 35 28 MHR mhr NN cord-333986-xkx181ek 35 29 . . . cord-333986-xkx181ek 36 1 Moderate moderate JJ cord-333986-xkx181ek 36 2 - - HYPH cord-333986-xkx181ek 36 3 intensity intensity NN cord-333986-xkx181ek 36 4 exercise exercise NN cord-333986-xkx181ek 36 5 should should MD cord-333986-xkx181ek 36 6 feel feel VB cord-333986-xkx181ek 36 7 somewhat somewhat RB cord-333986-xkx181ek 36 8 hard hard JJ cord-333986-xkx181ek 36 9 ; ; : cord-333986-xkx181ek 36 10 that that RB cord-333986-xkx181ek 36 11 is is RB cord-333986-xkx181ek 36 12 , , , cord-333986-xkx181ek 36 13 your -PRON- PRP$ cord-333986-xkx181ek 36 14 breathing breathing NN cord-333986-xkx181ek 36 15 quickens quicken VBZ cord-333986-xkx181ek 36 16 , , , cord-333986-xkx181ek 36 17 but but CC cord-333986-xkx181ek 36 18 you -PRON- PRP cord-333986-xkx181ek 36 19 are be VBP cord-333986-xkx181ek 36 20 not not RB cord-333986-xkx181ek 36 21 out out IN cord-333986-xkx181ek 36 22 of of IN cord-333986-xkx181ek 36 23 breath breath NN cord-333986-xkx181ek 36 24 . . . cord-333986-xkx181ek 37 1 You -PRON- PRP cord-333986-xkx181ek 37 2 develop develop VBP cord-333986-xkx181ek 37 3 a a DT cord-333986-xkx181ek 37 4 light light JJ cord-333986-xkx181ek 37 5 sweat sweat NN cord-333986-xkx181ek 37 6 after after IN cord-333986-xkx181ek 37 7 about about RB cord-333986-xkx181ek 37 8 10 10 CD cord-333986-xkx181ek 37 9 min min NN cord-333986-xkx181ek 37 10 of of IN cord-333986-xkx181ek 37 11 activity activity NN cord-333986-xkx181ek 37 12 , , , cord-333986-xkx181ek 37 13 but but CC cord-333986-xkx181ek 37 14 you -PRON- PRP cord-333986-xkx181ek 37 15 can can MD cord-333986-xkx181ek 37 16 carry carry VB cord-333986-xkx181ek 37 17 on on RP cord-333986-xkx181ek 37 18 a a DT cord-333986-xkx181ek 37 19 conversation conversation NN cord-333986-xkx181ek 37 20 ( ( -LRB- cord-333986-xkx181ek 37 21 from from IN cord-333986-xkx181ek 37 22 the the DT cord-333986-xkx181ek 37 23 Mayo Mayo NNP cord-333986-xkx181ek 37 24 Clinic Clinic NNP cord-333986-xkx181ek 37 25 [ [ -LRB- cord-333986-xkx181ek 37 26 45 45 CD cord-333986-xkx181ek 37 27 ] ] -RRB- cord-333986-xkx181ek 37 28 and and CC cord-333986-xkx181ek 37 29 the the DT cord-333986-xkx181ek 37 30 American American NNP cord-333986-xkx181ek 37 31 Heart Heart NNP cord-333986-xkx181ek 37 32 Association Association NNP cord-333986-xkx181ek 37 33 [ [ -LRB- cord-333986-xkx181ek 37 34 46 46 CD cord-333986-xkx181ek 37 35 ] ] -RRB- cord-333986-xkx181ek 37 36 ) ) -RRB- cord-333986-xkx181ek 37 37 . . . cord-333986-xkx181ek 38 1 We -PRON- PRP cord-333986-xkx181ek 38 2 define define VBP cord-333986-xkx181ek 38 3 high high JJ cord-333986-xkx181ek 38 4 - - HYPH cord-333986-xkx181ek 38 5 intensity intensity NN cord-333986-xkx181ek 38 6 ( ( -LRB- cord-333986-xkx181ek 38 7 also also RB cord-333986-xkx181ek 38 8 called call VBN cord-333986-xkx181ek 38 9 vigorous vigorous JJ cord-333986-xkx181ek 38 10 ) ) -RRB- cord-333986-xkx181ek 38 11 exercise exercise NN cord-333986-xkx181ek 38 12 as as IN cord-333986-xkx181ek 38 13 physical physical JJ cord-333986-xkx181ek 38 14 activity activity NN cord-333986-xkx181ek 38 15 where where WRB cord-333986-xkx181ek 38 16 your -PRON- PRP$ cord-333986-xkx181ek 38 17 heart heart NN cord-333986-xkx181ek 38 18 rate rate NN cord-333986-xkx181ek 38 19 increases increase NNS cord-333986-xkx181ek 38 20 to to IN cord-333986-xkx181ek 38 21 70 70 CD cord-333986-xkx181ek 38 22 - - SYM cord-333986-xkx181ek 38 23 85 85 CD cord-333986-xkx181ek 38 24 % % NN cord-333986-xkx181ek 38 25 of of IN cord-333986-xkx181ek 38 26 your -PRON- PRP$ cord-333986-xkx181ek 38 27 MHR mhr NN cord-333986-xkx181ek 38 28 . . . cord-333986-xkx181ek 39 1 The the DT cord-333986-xkx181ek 39 2 change change NN cord-333986-xkx181ek 39 3 found find VBN cord-333986-xkx181ek 39 4 in in IN cord-333986-xkx181ek 39 5 the the DT cord-333986-xkx181ek 39 6 immune immune JJ cord-333986-xkx181ek 39 7 system system NN cord-333986-xkx181ek 39 8 from from IN cord-333986-xkx181ek 39 9 exercise exercise NN cord-333986-xkx181ek 39 10 depends depend VBZ cord-333986-xkx181ek 39 11 on on IN cord-333986-xkx181ek 39 12 the the DT cord-333986-xkx181ek 39 13 duration duration NN cord-333986-xkx181ek 39 14 and and CC cord-333986-xkx181ek 39 15 the the DT cord-333986-xkx181ek 39 16 intensity intensity NN cord-333986-xkx181ek 39 17 of of IN cord-333986-xkx181ek 39 18 exercise exercise NN cord-333986-xkx181ek 39 19 [ [ -LRB- cord-333986-xkx181ek 39 20 27 27 CD cord-333986-xkx181ek 39 21 , , , cord-333986-xkx181ek 39 22 29 29 CD cord-333986-xkx181ek 39 23 , , , cord-333986-xkx181ek 39 24 30 30 CD cord-333986-xkx181ek 39 25 ] ] -RRB- cord-333986-xkx181ek 39 26 . . . cord-333986-xkx181ek 40 1 Defining define VBG cord-333986-xkx181ek 40 2 the the DT cord-333986-xkx181ek 40 3 immune immune JJ cord-333986-xkx181ek 40 4 system system NN cord-333986-xkx181ek 40 5 is be VBZ cord-333986-xkx181ek 40 6 somewhat somewhat RB cord-333986-xkx181ek 40 7 daunting daunting JJ cord-333986-xkx181ek 40 8 , , , cord-333986-xkx181ek 40 9 and and CC cord-333986-xkx181ek 40 10 describing describe VBG cord-333986-xkx181ek 40 11 it -PRON- PRP cord-333986-xkx181ek 40 12 in in IN cord-333986-xkx181ek 40 13 detail detail NN cord-333986-xkx181ek 40 14 is be VBZ cord-333986-xkx181ek 40 15 beyond beyond IN cord-333986-xkx181ek 40 16 the the DT cord-333986-xkx181ek 40 17 scope scope NN cord-333986-xkx181ek 40 18 of of IN cord-333986-xkx181ek 40 19 this this DT cord-333986-xkx181ek 40 20 review review NN cord-333986-xkx181ek 40 21 [ [ -LRB- cord-333986-xkx181ek 40 22 47 47 CD cord-333986-xkx181ek 40 23 ] ] -RRB- cord-333986-xkx181ek 40 24 . . . cord-333986-xkx181ek 41 1 The the DT cord-333986-xkx181ek 41 2 immune immune JJ cord-333986-xkx181ek 41 3 system system NN cord-333986-xkx181ek 41 4 protects protect VBZ cord-333986-xkx181ek 41 5 the the DT cord-333986-xkx181ek 41 6 body body NN cord-333986-xkx181ek 41 7 against against IN cord-333986-xkx181ek 41 8 infection infection NN cord-333986-xkx181ek 41 9 and and CC cord-333986-xkx181ek 41 10 non non JJ cord-333986-xkx181ek 41 11 - - JJ cord-333986-xkx181ek 41 12 native native JJ cord-333986-xkx181ek 41 13 substances substance NNS cord-333986-xkx181ek 41 14 through through IN cord-333986-xkx181ek 41 15 intricate intricate JJ cord-333986-xkx181ek 41 16 pathways pathway NNS cord-333986-xkx181ek 41 17 that that WDT cord-333986-xkx181ek 41 18 ultimately ultimately RB cord-333986-xkx181ek 41 19 distinguish distinguish VBP cord-333986-xkx181ek 41 20 everything everything NN cord-333986-xkx181ek 41 21 foreign foreign JJ cord-333986-xkx181ek 41 22 from from IN cord-333986-xkx181ek 41 23 nonforeign nonforeign NNP cord-333986-xkx181ek 41 24 within within IN cord-333986-xkx181ek 41 25 a a DT cord-333986-xkx181ek 41 26 given give VBN cord-333986-xkx181ek 41 27 person person NN cord-333986-xkx181ek 41 28 . . . cord-333986-xkx181ek 42 1 We -PRON- PRP cord-333986-xkx181ek 42 2 present present VBP cord-333986-xkx181ek 42 3 an an DT cord-333986-xkx181ek 42 4 overview overview NN cord-333986-xkx181ek 42 5 of of IN cord-333986-xkx181ek 42 6 the the DT cord-333986-xkx181ek 42 7 main main JJ cord-333986-xkx181ek 42 8 components component NNS cord-333986-xkx181ek 42 9 of of IN cord-333986-xkx181ek 42 10 the the DT cord-333986-xkx181ek 42 11 immune immune JJ cord-333986-xkx181ek 42 12 system system NN cord-333986-xkx181ek 42 13 , , , cord-333986-xkx181ek 42 14 especially especially RB cord-333986-xkx181ek 42 15 those those DT cord-333986-xkx181ek 42 16 central central JJ cord-333986-xkx181ek 42 17 to to IN cord-333986-xkx181ek 42 18 this this DT cord-333986-xkx181ek 42 19 review review NN cord-333986-xkx181ek 42 20 , , , cord-333986-xkx181ek 42 21 outlining outline VBG cord-333986-xkx181ek 42 22 the the DT cord-333986-xkx181ek 42 23 interplay interplay NN cord-333986-xkx181ek 42 24 of of IN cord-333986-xkx181ek 42 25 white white JJ cord-333986-xkx181ek 42 26 blood blood NN cord-333986-xkx181ek 42 27 cells cell NNS cord-333986-xkx181ek 42 28 and and CC cord-333986-xkx181ek 42 29 some some DT cord-333986-xkx181ek 42 30 of of IN cord-333986-xkx181ek 42 31 the the DT cord-333986-xkx181ek 42 32 many many JJ cord-333986-xkx181ek 42 33 biological biological JJ cord-333986-xkx181ek 42 34 responses response NNS cord-333986-xkx181ek 42 35 that that WDT cord-333986-xkx181ek 42 36 activate activate VBP cord-333986-xkx181ek 42 37 and and CC cord-333986-xkx181ek 42 38 control control VB cord-333986-xkx181ek 42 39 the the DT cord-333986-xkx181ek 42 40 immune immune JJ cord-333986-xkx181ek 42 41 system system NN cord-333986-xkx181ek 42 42 ( ( -LRB- cord-333986-xkx181ek 42 43 Figure figure NN cord-333986-xkx181ek 42 44 2 2 CD cord-333986-xkx181ek 42 45 ) ) -RRB- cord-333986-xkx181ek 42 46 . . . cord-333986-xkx181ek 42 47 _SP cord-333986-xkx181ek 43 1 Exercise exercise NN cord-333986-xkx181ek 43 2 is be VBZ cord-333986-xkx181ek 43 3 a a DT cord-333986-xkx181ek 43 4 physical physical JJ cord-333986-xkx181ek 43 5 activity activity NN cord-333986-xkx181ek 43 6 that that WDT cord-333986-xkx181ek 43 7 requires require VBZ cord-333986-xkx181ek 43 8 effort effort NN cord-333986-xkx181ek 43 9 , , , cord-333986-xkx181ek 43 10 and and CC cord-333986-xkx181ek 43 11 it -PRON- PRP cord-333986-xkx181ek 43 12 is be VBZ cord-333986-xkx181ek 43 13 usually usually RB cord-333986-xkx181ek 43 14 carried carry VBN cord-333986-xkx181ek 43 15 out out RP cord-333986-xkx181ek 43 16 to to TO cord-333986-xkx181ek 43 17 sustain sustain VB cord-333986-xkx181ek 43 18 or or CC cord-333986-xkx181ek 43 19 improve improve VB cord-333986-xkx181ek 43 20 health health NN cord-333986-xkx181ek 43 21 and and CC cord-333986-xkx181ek 43 22 fitness fitness NN cord-333986-xkx181ek 43 23 [ [ -LRB- cord-333986-xkx181ek 43 24 43 43 CD cord-333986-xkx181ek 43 25 , , , cord-333986-xkx181ek 43 26 44 44 CD cord-333986-xkx181ek 43 27 ] ] -RRB- cord-333986-xkx181ek 43 28 . . . cord-333986-xkx181ek 44 1 We -PRON- PRP cord-333986-xkx181ek 44 2 define define VBP cord-333986-xkx181ek 44 3 low low JJ cord-333986-xkx181ek 44 4 - - HYPH cord-333986-xkx181ek 44 5 intensity intensity NN cord-333986-xkx181ek 44 6 exercise exercise NN cord-333986-xkx181ek 44 7 as as IN cord-333986-xkx181ek 44 8 activity activity NN cord-333986-xkx181ek 44 9 that that WDT cord-333986-xkx181ek 44 10 increases increase VBZ cord-333986-xkx181ek 44 11 your -PRON- PRP$ cord-333986-xkx181ek 44 12 heart heart NN cord-333986-xkx181ek 44 13 rate rate NN cord-333986-xkx181ek 44 14 up up IN cord-333986-xkx181ek 44 15 to to TO cord-333986-xkx181ek 44 16 40 40 CD cord-333986-xkx181ek 44 17 - - SYM cord-333986-xkx181ek 44 18 50 50 CD cord-333986-xkx181ek 44 19 % % NN cord-333986-xkx181ek 44 20 of of IN cord-333986-xkx181ek 44 21 your -PRON- PRP$ cord-333986-xkx181ek 44 22 maximum maximum JJ cord-333986-xkx181ek 44 23 heart heart NN cord-333986-xkx181ek 44 24 rate rate NN cord-333986-xkx181ek 44 25 ( ( -LRB- cord-333986-xkx181ek 44 26 MHR MHR NNP cord-333986-xkx181ek 44 27 ) ) -RRB- cord-333986-xkx181ek 44 28 . . . cord-333986-xkx181ek 45 1 This this DT cord-333986-xkx181ek 45 2 would would MD cord-333986-xkx181ek 45 3 include include VB cord-333986-xkx181ek 45 4 a a DT cord-333986-xkx181ek 45 5 casual casual JJ cord-333986-xkx181ek 45 6 walk walk NN cord-333986-xkx181ek 45 7 with with IN cord-333986-xkx181ek 45 8 a a DT cord-333986-xkx181ek 45 9 pet pet JJ cord-333986-xkx181ek 45 10 dog dog NN cord-333986-xkx181ek 45 11 or or CC cord-333986-xkx181ek 45 12 walking walk VBG cord-333986-xkx181ek 45 13 up up RP cord-333986-xkx181ek 45 14 a a DT cord-333986-xkx181ek 45 15 few few JJ cord-333986-xkx181ek 45 16 flights flight NNS cord-333986-xkx181ek 45 17 of of IN cord-333986-xkx181ek 45 18 steps step NNS cord-333986-xkx181ek 45 19 instead instead RB cord-333986-xkx181ek 45 20 of of IN cord-333986-xkx181ek 45 21 taking take VBG cord-333986-xkx181ek 45 22 the the DT cord-333986-xkx181ek 45 23 elevator elevator NN cord-333986-xkx181ek 45 24 . . . cord-333986-xkx181ek 46 1 We -PRON- PRP cord-333986-xkx181ek 46 2 define define VBP cord-333986-xkx181ek 46 3 moderate moderate JJ cord-333986-xkx181ek 46 4 - - HYPH cord-333986-xkx181ek 46 5 intensity intensity NN cord-333986-xkx181ek 46 6 ( ( -LRB- cord-333986-xkx181ek 46 7 or or CC cord-333986-xkx181ek 46 8 simply simply RB cord-333986-xkx181ek 46 9 moderate moderate JJ cord-333986-xkx181ek 46 10 ) ) -RRB- cord-333986-xkx181ek 46 11 exercise exercise NN cord-333986-xkx181ek 46 12 as as IN cord-333986-xkx181ek 46 13 physical physical JJ cord-333986-xkx181ek 46 14 activity activity NN cord-333986-xkx181ek 46 15 for for IN cord-333986-xkx181ek 46 16 ≤60 ≤60 NNP cord-333986-xkx181ek 46 17 min min NNP cord-333986-xkx181ek 46 18 that that WDT cord-333986-xkx181ek 46 19 increases increase VBZ cord-333986-xkx181ek 46 20 your -PRON- PRP$ cord-333986-xkx181ek 46 21 heart heart NN cord-333986-xkx181ek 46 22 rate rate NN cord-333986-xkx181ek 46 23 to to IN cord-333986-xkx181ek 46 24 50 50 CD cord-333986-xkx181ek 46 25 - - SYM cord-333986-xkx181ek 46 26 70 70 CD cord-333986-xkx181ek 46 27 % % NN cord-333986-xkx181ek 46 28 of of IN cord-333986-xkx181ek 46 29 your -PRON- PRP$ cord-333986-xkx181ek 46 30 MHR mhr NN cord-333986-xkx181ek 46 31 . . . cord-333986-xkx181ek 47 1 Moderate moderate JJ cord-333986-xkx181ek 47 2 - - HYPH cord-333986-xkx181ek 47 3 intensity intensity NN cord-333986-xkx181ek 47 4 exercise exercise NN cord-333986-xkx181ek 47 5 should should MD cord-333986-xkx181ek 47 6 feel feel VB cord-333986-xkx181ek 47 7 somewhat somewhat RB cord-333986-xkx181ek 47 8 hard hard JJ cord-333986-xkx181ek 47 9 ; ; : cord-333986-xkx181ek 47 10 that that RB cord-333986-xkx181ek 47 11 is is RB cord-333986-xkx181ek 47 12 , , , cord-333986-xkx181ek 47 13 your -PRON- PRP$ cord-333986-xkx181ek 47 14 breathing breathing NN cord-333986-xkx181ek 47 15 quickens quicken VBZ cord-333986-xkx181ek 47 16 , , , cord-333986-xkx181ek 47 17 but but CC cord-333986-xkx181ek 47 18 you -PRON- PRP cord-333986-xkx181ek 47 19 are be VBP cord-333986-xkx181ek 47 20 not not RB cord-333986-xkx181ek 47 21 out out IN cord-333986-xkx181ek 47 22 of of IN cord-333986-xkx181ek 47 23 breath breath NN cord-333986-xkx181ek 47 24 . . . cord-333986-xkx181ek 48 1 You -PRON- PRP cord-333986-xkx181ek 48 2 develop develop VBP cord-333986-xkx181ek 48 3 a a DT cord-333986-xkx181ek 48 4 light light JJ cord-333986-xkx181ek 48 5 sweat sweat NN cord-333986-xkx181ek 48 6 after after IN cord-333986-xkx181ek 48 7 about about RB cord-333986-xkx181ek 48 8 10 10 CD cord-333986-xkx181ek 48 9 min min NN cord-333986-xkx181ek 48 10 of of IN cord-333986-xkx181ek 48 11 activity activity NN cord-333986-xkx181ek 48 12 , , , cord-333986-xkx181ek 48 13 but but CC cord-333986-xkx181ek 48 14 you -PRON- PRP cord-333986-xkx181ek 48 15 can can MD cord-333986-xkx181ek 48 16 carry carry VB cord-333986-xkx181ek 48 17 on on RP cord-333986-xkx181ek 48 18 a a DT cord-333986-xkx181ek 48 19 conversation conversation NN cord-333986-xkx181ek 48 20 ( ( -LRB- cord-333986-xkx181ek 48 21 from from IN cord-333986-xkx181ek 48 22 the the DT cord-333986-xkx181ek 48 23 Mayo Mayo NNP cord-333986-xkx181ek 48 24 Clinic Clinic NNP cord-333986-xkx181ek 48 25 [ [ -LRB- cord-333986-xkx181ek 48 26 45 45 CD cord-333986-xkx181ek 48 27 ] ] -RRB- cord-333986-xkx181ek 48 28 and and CC cord-333986-xkx181ek 48 29 the the DT cord-333986-xkx181ek 48 30 American American NNP cord-333986-xkx181ek 48 31 Heart Heart NNP cord-333986-xkx181ek 48 32 Association Association NNP cord-333986-xkx181ek 48 33 [ [ -LRB- cord-333986-xkx181ek 48 34 46 46 CD cord-333986-xkx181ek 48 35 ] ] -RRB- cord-333986-xkx181ek 48 36 ) ) -RRB- cord-333986-xkx181ek 48 37 . . . cord-333986-xkx181ek 49 1 We -PRON- PRP cord-333986-xkx181ek 49 2 define define VBP cord-333986-xkx181ek 49 3 high high JJ cord-333986-xkx181ek 49 4 - - HYPH cord-333986-xkx181ek 49 5 intensity intensity NN cord-333986-xkx181ek 49 6 ( ( -LRB- cord-333986-xkx181ek 49 7 also also RB cord-333986-xkx181ek 49 8 called call VBN cord-333986-xkx181ek 49 9 vigorous vigorous JJ cord-333986-xkx181ek 49 10 ) ) -RRB- cord-333986-xkx181ek 49 11 exercise exercise NN cord-333986-xkx181ek 49 12 as as IN cord-333986-xkx181ek 49 13 physical physical JJ cord-333986-xkx181ek 49 14 activity activity NN cord-333986-xkx181ek 49 15 where where WRB cord-333986-xkx181ek 49 16 your -PRON- PRP$ cord-333986-xkx181ek 49 17 heart heart NN cord-333986-xkx181ek 49 18 rate rate NN cord-333986-xkx181ek 49 19 increases increase NNS cord-333986-xkx181ek 49 20 to to IN cord-333986-xkx181ek 49 21 70 70 CD cord-333986-xkx181ek 49 22 - - SYM cord-333986-xkx181ek 49 23 85 85 CD cord-333986-xkx181ek 49 24 % % NN cord-333986-xkx181ek 49 25 of of IN cord-333986-xkx181ek 49 26 your -PRON- PRP$ cord-333986-xkx181ek 49 27 MHR mhr NN cord-333986-xkx181ek 49 28 . . . cord-333986-xkx181ek 50 1 The the DT cord-333986-xkx181ek 50 2 change change NN cord-333986-xkx181ek 50 3 found find VBN cord-333986-xkx181ek 50 4 in in IN cord-333986-xkx181ek 50 5 the the DT cord-333986-xkx181ek 50 6 immune immune JJ cord-333986-xkx181ek 50 7 system system NN cord-333986-xkx181ek 50 8 from from IN cord-333986-xkx181ek 50 9 exercise exercise NN cord-333986-xkx181ek 50 10 depends depend VBZ cord-333986-xkx181ek 50 11 on on IN cord-333986-xkx181ek 50 12 the the DT cord-333986-xkx181ek 50 13 duration duration NN cord-333986-xkx181ek 50 14 and and CC cord-333986-xkx181ek 50 15 the the DT cord-333986-xkx181ek 50 16 intensity intensity NN cord-333986-xkx181ek 50 17 of of IN cord-333986-xkx181ek 50 18 exercise exercise NN cord-333986-xkx181ek 50 19 [ [ -LRB- cord-333986-xkx181ek 50 20 27 27 CD cord-333986-xkx181ek 50 21 , , , cord-333986-xkx181ek 50 22 29 29 CD cord-333986-xkx181ek 50 23 , , , cord-333986-xkx181ek 50 24 30 30 CD cord-333986-xkx181ek 50 25 ] ] -RRB- cord-333986-xkx181ek 50 26 . . . cord-333986-xkx181ek 51 1 Defining define VBG cord-333986-xkx181ek 51 2 the the DT cord-333986-xkx181ek 51 3 immune immune JJ cord-333986-xkx181ek 51 4 system system NN cord-333986-xkx181ek 51 5 is be VBZ cord-333986-xkx181ek 51 6 somewhat somewhat RB cord-333986-xkx181ek 51 7 daunting daunting JJ cord-333986-xkx181ek 51 8 , , , cord-333986-xkx181ek 51 9 and and CC cord-333986-xkx181ek 51 10 describing describe VBG cord-333986-xkx181ek 51 11 it -PRON- PRP cord-333986-xkx181ek 51 12 in in IN cord-333986-xkx181ek 51 13 detail detail NN cord-333986-xkx181ek 51 14 is be VBZ cord-333986-xkx181ek 51 15 beyond beyond IN cord-333986-xkx181ek 51 16 the the DT cord-333986-xkx181ek 51 17 scope scope NN cord-333986-xkx181ek 51 18 of of IN cord-333986-xkx181ek 51 19 this this DT cord-333986-xkx181ek 51 20 review review NN cord-333986-xkx181ek 51 21 [ [ -LRB- cord-333986-xkx181ek 51 22 47 47 CD cord-333986-xkx181ek 51 23 ] ] -RRB- cord-333986-xkx181ek 51 24 . . . cord-333986-xkx181ek 52 1 The the DT cord-333986-xkx181ek 52 2 immune immune JJ cord-333986-xkx181ek 52 3 system system NN cord-333986-xkx181ek 52 4 protects protect VBZ cord-333986-xkx181ek 52 5 the the DT cord-333986-xkx181ek 52 6 body body NN cord-333986-xkx181ek 52 7 against against IN cord-333986-xkx181ek 52 8 infection infection NN cord-333986-xkx181ek 52 9 and and CC cord-333986-xkx181ek 52 10 non non JJ cord-333986-xkx181ek 52 11 - - JJ cord-333986-xkx181ek 52 12 native native JJ cord-333986-xkx181ek 52 13 substances substance NNS cord-333986-xkx181ek 52 14 through through IN cord-333986-xkx181ek 52 15 intricate intricate JJ cord-333986-xkx181ek 52 16 pathways pathway NNS cord-333986-xkx181ek 52 17 that that WDT cord-333986-xkx181ek 52 18 ultimately ultimately RB cord-333986-xkx181ek 52 19 distinguish distinguish VBP cord-333986-xkx181ek 52 20 everything everything NN cord-333986-xkx181ek 52 21 foreign foreign JJ cord-333986-xkx181ek 52 22 from from IN cord-333986-xkx181ek 52 23 nonforeign nonforeign NNP cord-333986-xkx181ek 52 24 within within IN cord-333986-xkx181ek 52 25 a a DT cord-333986-xkx181ek 52 26 given give VBN cord-333986-xkx181ek 52 27 person person NN cord-333986-xkx181ek 52 28 . . . cord-333986-xkx181ek 53 1 We -PRON- PRP cord-333986-xkx181ek 53 2 present present VBP cord-333986-xkx181ek 53 3 an an DT cord-333986-xkx181ek 53 4 overview overview NN cord-333986-xkx181ek 53 5 of of IN cord-333986-xkx181ek 53 6 the the DT cord-333986-xkx181ek 53 7 main main JJ cord-333986-xkx181ek 53 8 components component NNS cord-333986-xkx181ek 53 9 of of IN cord-333986-xkx181ek 53 10 the the DT cord-333986-xkx181ek 53 11 immune immune JJ cord-333986-xkx181ek 53 12 system system NN cord-333986-xkx181ek 53 13 , , , cord-333986-xkx181ek 53 14 especially especially RB cord-333986-xkx181ek 53 15 those those DT cord-333986-xkx181ek 53 16 central central JJ cord-333986-xkx181ek 53 17 to to IN cord-333986-xkx181ek 53 18 this this DT cord-333986-xkx181ek 53 19 review review NN cord-333986-xkx181ek 53 20 , , , cord-333986-xkx181ek 53 21 outlining outline VBG cord-333986-xkx181ek 53 22 the the DT cord-333986-xkx181ek 53 23 interplay interplay NN cord-333986-xkx181ek 53 24 of of IN cord-333986-xkx181ek 53 25 white white JJ cord-333986-xkx181ek 53 26 blood blood NN cord-333986-xkx181ek 53 27 cells cell NNS cord-333986-xkx181ek 53 28 and and CC cord-333986-xkx181ek 53 29 some some DT cord-333986-xkx181ek 53 30 of of IN cord-333986-xkx181ek 53 31 the the DT cord-333986-xkx181ek 53 32 many many JJ cord-333986-xkx181ek 53 33 biological biological JJ cord-333986-xkx181ek 53 34 responses response NNS cord-333986-xkx181ek 53 35 that that WDT cord-333986-xkx181ek 53 36 activate activate VBP cord-333986-xkx181ek 53 37 and and CC cord-333986-xkx181ek 53 38 control control VB cord-333986-xkx181ek 53 39 the the DT cord-333986-xkx181ek 53 40 immune immune JJ cord-333986-xkx181ek 53 41 system system NN cord-333986-xkx181ek 53 42 ( ( -LRB- cord-333986-xkx181ek 53 43 Figure figure NN cord-333986-xkx181ek 53 44 2 2 CD cord-333986-xkx181ek 53 45 ) ) -RRB- cord-333986-xkx181ek 53 46 . . . cord-333986-xkx181ek 54 1 Brain Brain NNP cord-333986-xkx181ek 54 2 Sci Sci NNP cord-333986-xkx181ek 54 3 . . . cord-333986-xkx181ek 55 1 2020 2020 CD cord-333986-xkx181ek 55 2 , , , cord-333986-xkx181ek 55 3 10 10 CD cord-333986-xkx181ek 55 4 , , , cord-333986-xkx181ek 56 1 x x NN cord-333986-xkx181ek 56 2 FOR for IN cord-333986-xkx181ek 56 3 PEER peer NN cord-333986-xkx181ek 56 4 REVIEW REVIEW NNP cord-333986-xkx181ek 56 5 2 2 CD cord-333986-xkx181ek 56 6 of of IN cord-333986-xkx181ek 56 7 19 19 CD cord-333986-xkx181ek 56 8 An an DT cord-333986-xkx181ek 56 9 essential essential JJ cord-333986-xkx181ek 56 10 aspect aspect NN cord-333986-xkx181ek 56 11 of of IN cord-333986-xkx181ek 56 12 the the DT cord-333986-xkx181ek 56 13 immune immune JJ cord-333986-xkx181ek 56 14 system system NN cord-333986-xkx181ek 56 15 is be VBZ cord-333986-xkx181ek 56 16 inflammation inflammation NN cord-333986-xkx181ek 56 17 , , , cord-333986-xkx181ek 56 18 which which WDT cord-333986-xkx181ek 56 19 is be VBZ cord-333986-xkx181ek 56 20 the the DT cord-333986-xkx181ek 56 21 immune immune JJ cord-333986-xkx181ek 56 22 system system NN cord-333986-xkx181ek 56 23 's 's POS cord-333986-xkx181ek 56 24 response response NN cord-333986-xkx181ek 56 25 to to IN cord-333986-xkx181ek 56 26 infection infection NN cord-333986-xkx181ek 56 27 , , , cord-333986-xkx181ek 56 28 injury injury NN cord-333986-xkx181ek 56 29 , , , cord-333986-xkx181ek 56 30 and and CC cord-333986-xkx181ek 56 31 toxic toxic JJ cord-333986-xkx181ek 56 32 compounds compound NNS cord-333986-xkx181ek 56 33 ( ( -LRB- cord-333986-xkx181ek 56 34 Figure figure NN cord-333986-xkx181ek 56 35 2 2 CD cord-333986-xkx181ek 56 36 ) ) -RRB- cord-333986-xkx181ek 56 37 . . . cord-333986-xkx181ek 57 1 We -PRON- PRP cord-333986-xkx181ek 57 2 consider consider VBP cord-333986-xkx181ek 57 3 the the DT cord-333986-xkx181ek 57 4 inflammatory inflammatory JJ cord-333986-xkx181ek 57 5 process process NN cord-333986-xkx181ek 57 6 to to TO cord-333986-xkx181ek 57 7 be be VB cord-333986-xkx181ek 57 8 a a DT cord-333986-xkx181ek 57 9 host host NN cord-333986-xkx181ek 57 10 - - HYPH cord-333986-xkx181ek 57 11 defense defense NN cord-333986-xkx181ek 57 12 response response NN cord-333986-xkx181ek 57 13 mechanism mechanism NN cord-333986-xkx181ek 57 14 . . . cord-333986-xkx181ek 58 1 Unfortunately unfortunately RB cord-333986-xkx181ek 58 2 , , , cord-333986-xkx181ek 58 3 inflammation inflammation NN cord-333986-xkx181ek 58 4 , , , cord-333986-xkx181ek 58 5 if if IN cord-333986-xkx181ek 58 6 not not RB cord-333986-xkx181ek 58 7 controlled control VBN cord-333986-xkx181ek 58 8 , , , cord-333986-xkx181ek 58 9 can can MD cord-333986-xkx181ek 58 10 result result VB cord-333986-xkx181ek 58 11 in in IN cord-333986-xkx181ek 58 12 host host NN cord-333986-xkx181ek 58 13 morbidity morbidity NN cord-333986-xkx181ek 58 14 and and CC cord-333986-xkx181ek 58 15 mortality mortality NN cord-333986-xkx181ek 58 16 . . . cord-333986-xkx181ek 59 1 In in IN cord-333986-xkx181ek 59 2 severe severe JJ cord-333986-xkx181ek 59 3 COVID-19 covid-19 NN cord-333986-xkx181ek 59 4 , , , cord-333986-xkx181ek 59 5 there there EX cord-333986-xkx181ek 59 6 is be VBZ cord-333986-xkx181ek 59 7 potential potential JJ cord-333986-xkx181ek 59 8 for for IN cord-333986-xkx181ek 59 9 an an DT cord-333986-xkx181ek 59 10 exponential exponential JJ cord-333986-xkx181ek 59 11 release release NN cord-333986-xkx181ek 59 12 of of IN cord-333986-xkx181ek 59 13 pro pro JJ cord-333986-xkx181ek 59 14 - - JJ cord-333986-xkx181ek 59 15 inflammatory inflammatory JJ cord-333986-xkx181ek 59 16 cytokines cytokine NNS cord-333986-xkx181ek 59 17 ( ( -LRB- cord-333986-xkx181ek 59 18 termed term VBN cord-333986-xkx181ek 59 19 Cytokine Cytokine NNP cord-333986-xkx181ek 59 20 Storm Storm NNP cord-333986-xkx181ek 59 21 Syndrome Syndrome NNP cord-333986-xkx181ek 59 22 ) ) -RRB- cord-333986-xkx181ek 59 23 , , , cord-333986-xkx181ek 59 24 which which WDT cord-333986-xkx181ek 59 25 can can MD cord-333986-xkx181ek 59 26 result result VB cord-333986-xkx181ek 59 27 in in IN cord-333986-xkx181ek 59 28 uncontrolled uncontrolled JJ cord-333986-xkx181ek 59 29 inflammation inflammation NN cord-333986-xkx181ek 59 30 and and CC cord-333986-xkx181ek 59 31 result result VB cord-333986-xkx181ek 59 32 in in IN cord-333986-xkx181ek 59 33 multi multi JJ cord-333986-xkx181ek 59 34 - - JJ cord-333986-xkx181ek 59 35 organ organ JJ cord-333986-xkx181ek 59 36 damage damage NN cord-333986-xkx181ek 59 37 with with IN cord-333986-xkx181ek 59 38 frequent frequent JJ cord-333986-xkx181ek 59 39 progression progression NN cord-333986-xkx181ek 59 40 to to IN cord-333986-xkx181ek 59 41 death death NN cord-333986-xkx181ek 59 42 [ [ -LRB- cord-333986-xkx181ek 59 43 21 21 CD cord-333986-xkx181ek 59 44 , , , cord-333986-xkx181ek 59 45 22 22 CD cord-333986-xkx181ek 59 46 ] ] -RRB- cord-333986-xkx181ek 59 47 . . . cord-333986-xkx181ek 60 1 An an DT cord-333986-xkx181ek 60 2 essential essential JJ cord-333986-xkx181ek 60 3 aspect aspect NN cord-333986-xkx181ek 60 4 of of IN cord-333986-xkx181ek 60 5 the the DT cord-333986-xkx181ek 60 6 immune immune JJ cord-333986-xkx181ek 60 7 system system NN cord-333986-xkx181ek 60 8 is be VBZ cord-333986-xkx181ek 60 9 inflammation inflammation NN cord-333986-xkx181ek 60 10 , , , cord-333986-xkx181ek 60 11 which which WDT cord-333986-xkx181ek 60 12 is be VBZ cord-333986-xkx181ek 60 13 the the DT cord-333986-xkx181ek 60 14 immune immune JJ cord-333986-xkx181ek 60 15 system system NN cord-333986-xkx181ek 60 16 's 's POS cord-333986-xkx181ek 60 17 response response NN cord-333986-xkx181ek 60 18 to to IN cord-333986-xkx181ek 60 19 infection infection NN cord-333986-xkx181ek 60 20 , , , cord-333986-xkx181ek 60 21 injury injury NN cord-333986-xkx181ek 60 22 , , , cord-333986-xkx181ek 60 23 and and CC cord-333986-xkx181ek 60 24 toxic toxic JJ cord-333986-xkx181ek 60 25 compounds compound NNS cord-333986-xkx181ek 60 26 ( ( -LRB- cord-333986-xkx181ek 60 27 Figure figure NN cord-333986-xkx181ek 60 28 2 2 CD cord-333986-xkx181ek 60 29 ) ) -RRB- cord-333986-xkx181ek 60 30 . . . cord-333986-xkx181ek 61 1 We -PRON- PRP cord-333986-xkx181ek 61 2 consider consider VBP cord-333986-xkx181ek 61 3 the the DT cord-333986-xkx181ek 61 4 inflammatory inflammatory JJ cord-333986-xkx181ek 61 5 process process NN cord-333986-xkx181ek 61 6 to to TO cord-333986-xkx181ek 61 7 be be VB cord-333986-xkx181ek 61 8 a a DT cord-333986-xkx181ek 61 9 host host NN cord-333986-xkx181ek 61 10 - - HYPH cord-333986-xkx181ek 61 11 defense defense NN cord-333986-xkx181ek 61 12 response response NN cord-333986-xkx181ek 61 13 mechanism mechanism NN cord-333986-xkx181ek 61 14 . . . cord-333986-xkx181ek 62 1 Unfortunately unfortunately RB cord-333986-xkx181ek 62 2 , , , cord-333986-xkx181ek 62 3 inflammation inflammation NN cord-333986-xkx181ek 62 4 , , , cord-333986-xkx181ek 62 5 if if IN cord-333986-xkx181ek 62 6 not not RB cord-333986-xkx181ek 62 7 controlled control VBN cord-333986-xkx181ek 62 8 , , , cord-333986-xkx181ek 62 9 can can MD cord-333986-xkx181ek 62 10 result result VB cord-333986-xkx181ek 62 11 in in IN cord-333986-xkx181ek 62 12 host host NN cord-333986-xkx181ek 62 13 morbidity morbidity NN cord-333986-xkx181ek 62 14 and and CC cord-333986-xkx181ek 62 15 mortality mortality NN cord-333986-xkx181ek 62 16 . . . cord-333986-xkx181ek 63 1 In in IN cord-333986-xkx181ek 63 2 severe severe JJ cord-333986-xkx181ek 63 3 COVID-19 covid-19 NN cord-333986-xkx181ek 63 4 , , , cord-333986-xkx181ek 63 5 there there EX cord-333986-xkx181ek 63 6 is be VBZ cord-333986-xkx181ek 63 7 potential potential JJ cord-333986-xkx181ek 63 8 for for IN cord-333986-xkx181ek 63 9 an an DT cord-333986-xkx181ek 63 10 exponential exponential JJ cord-333986-xkx181ek 63 11 release release NN cord-333986-xkx181ek 63 12 of of IN cord-333986-xkx181ek 63 13 pro pro JJ cord-333986-xkx181ek 63 14 - - JJ cord-333986-xkx181ek 63 15 inflammatory inflammatory JJ cord-333986-xkx181ek 63 16 cytokines cytokine NNS cord-333986-xkx181ek 63 17 ( ( -LRB- cord-333986-xkx181ek 63 18 termed term VBN cord-333986-xkx181ek 63 19 Cytokine Cytokine NNP cord-333986-xkx181ek 63 20 Storm Storm NNP cord-333986-xkx181ek 63 21 Syndrome Syndrome NNP cord-333986-xkx181ek 63 22 ) ) -RRB- cord-333986-xkx181ek 63 23 , , , cord-333986-xkx181ek 63 24 which which WDT cord-333986-xkx181ek 63 25 can can MD cord-333986-xkx181ek 63 26 result result VB cord-333986-xkx181ek 63 27 in in IN cord-333986-xkx181ek 63 28 uncontrolled uncontrolled JJ cord-333986-xkx181ek 63 29 inflammation inflammation NN cord-333986-xkx181ek 63 30 and and CC cord-333986-xkx181ek 63 31 result result VB cord-333986-xkx181ek 63 32 in in IN cord-333986-xkx181ek 63 33 multi multi JJ cord-333986-xkx181ek 63 34 - - JJ cord-333986-xkx181ek 63 35 organ organ JJ cord-333986-xkx181ek 63 36 damage damage NN cord-333986-xkx181ek 63 37 with with IN cord-333986-xkx181ek 63 38 frequent frequent JJ cord-333986-xkx181ek 63 39 progression progression NN cord-333986-xkx181ek 63 40 to to IN cord-333986-xkx181ek 63 41 death death NN cord-333986-xkx181ek 63 42 [ [ -LRB- cord-333986-xkx181ek 63 43 21 21 CD cord-333986-xkx181ek 63 44 , , , cord-333986-xkx181ek 63 45 22 22 CD cord-333986-xkx181ek 63 46 ] ] -RRB- cord-333986-xkx181ek 63 47 . . . cord-333986-xkx181ek 64 1 Both both DT cord-333986-xkx181ek 64 2 cross cross JJ cord-333986-xkx181ek 64 3 - - JJ cord-333986-xkx181ek 64 4 sectional sectional JJ cord-333986-xkx181ek 64 5 and and CC cord-333986-xkx181ek 64 6 longitudinal longitudinal JJ cord-333986-xkx181ek 64 7 data datum NNS cord-333986-xkx181ek 64 8 have have VBP cord-333986-xkx181ek 64 9 shown show VBN cord-333986-xkx181ek 64 10 that that IN cord-333986-xkx181ek 64 11 individuals individual NNS cord-333986-xkx181ek 64 12 who who WP cord-333986-xkx181ek 64 13 participate participate VBP cord-333986-xkx181ek 64 14 in in IN cord-333986-xkx181ek 64 15 moderate moderate JJ cord-333986-xkx181ek 64 16 - - HYPH cord-333986-xkx181ek 64 17 intensity intensity NN cord-333986-xkx181ek 64 18 exercise exercise NN cord-333986-xkx181ek 64 19 self self NN cord-333986-xkx181ek 64 20 - - HYPH cord-333986-xkx181ek 64 21 report report VBP cord-333986-xkx181ek 64 22 less less RBR cord-333986-xkx181ek 64 23 upper upper JJ cord-333986-xkx181ek 64 24 respiratory respiratory JJ cord-333986-xkx181ek 64 25 tract tract NN cord-333986-xkx181ek 64 26 infections infection NNS cord-333986-xkx181ek 64 27 ( ( -LRB- cord-333986-xkx181ek 64 28 URTI URTI NNP cord-333986-xkx181ek 64 29 ) ) -RRB- cord-333986-xkx181ek 64 30 . . . cord-333986-xkx181ek 65 1 Additionally additionally RB cord-333986-xkx181ek 65 2 , , , cord-333986-xkx181ek 65 3 in in IN cord-333986-xkx181ek 65 4 animal animal NN cord-333986-xkx181ek 65 5 models model NNS cord-333986-xkx181ek 65 6 , , , cord-333986-xkx181ek 65 7 those those DT cord-333986-xkx181ek 65 8 exposed expose VBN cord-333986-xkx181ek 65 9 to to IN cord-333986-xkx181ek 65 10 moderate moderate JJ cord-333986-xkx181ek 65 11 - - HYPH cord-333986-xkx181ek 65 12 intensity intensity NN cord-333986-xkx181ek 65 13 exercise exercise NN cord-333986-xkx181ek 65 14 before before IN cord-333986-xkx181ek 65 15 symptom symptom NN cord-333986-xkx181ek 65 16 presentation presentation NN cord-333986-xkx181ek 65 17 have have VBP cord-333986-xkx181ek 65 18 lower low JJR cord-333986-xkx181ek 65 19 rates rate NNS cord-333986-xkx181ek 65 20 of of IN cord-333986-xkx181ek 65 21 mortality mortality NN cord-333986-xkx181ek 65 22 [ [ -LRB- cord-333986-xkx181ek 65 23 48 48 CD cord-333986-xkx181ek 65 24 , , , cord-333986-xkx181ek 65 25 49 49 CD cord-333986-xkx181ek 65 26 ] ] -RRB- cord-333986-xkx181ek 65 27 . . . cord-333986-xkx181ek 66 1 A a DT cord-333986-xkx181ek 66 2 prospective prospective JJ cord-333986-xkx181ek 66 3 study study NN cord-333986-xkx181ek 66 4 in in IN cord-333986-xkx181ek 66 5 humans human NNS cord-333986-xkx181ek 66 6 assessing assess VBG cord-333986-xkx181ek 66 7 the the DT cord-333986-xkx181ek 66 8 dose dose JJ cord-333986-xkx181ek 66 9 - - HYPH cord-333986-xkx181ek 66 10 response response NN cord-333986-xkx181ek 66 11 relationship relationship NN cord-333986-xkx181ek 66 12 between between IN cord-333986-xkx181ek 66 13 moderate moderate JJ cord-333986-xkx181ek 66 14 walking walking NN cord-333986-xkx181ek 66 15 / / SYM cord-333986-xkx181ek 66 16 running run VBG cord-333986-xkx181ek 66 17 energy energy NN cord-333986-xkx181ek 66 18 expenditure expenditure NN cord-333986-xkx181ek 66 19 and and CC cord-333986-xkx181ek 66 20 pneumonia pneumonia NN cord-333986-xkx181ek 66 21 , , , cord-333986-xkx181ek 66 22 respiratory respiratory JJ cord-333986-xkx181ek 66 23 disease disease NN cord-333986-xkx181ek 66 24 , , , cord-333986-xkx181ek 66 25 and and CC cord-333986-xkx181ek 66 26 aspiration aspiration NN cord-333986-xkx181ek 66 27 pneumonia pneumonia NN cord-333986-xkx181ek 66 28 mortality mortality NN cord-333986-xkx181ek 66 29 , , , cord-333986-xkx181ek 66 30 found find VBD cord-333986-xkx181ek 66 31 that that IN cord-333986-xkx181ek 66 32 higher high JJR cord-333986-xkx181ek 66 33 doses dose NNS cord-333986-xkx181ek 66 34 of of IN cord-333986-xkx181ek 66 35 moderate moderate JJ cord-333986-xkx181ek 66 36 exercise exercise NN cord-333986-xkx181ek 66 37 decreased decrease VBD cord-333986-xkx181ek 66 38 mortality mortality NN cord-333986-xkx181ek 66 39 in in IN cord-333986-xkx181ek 66 40 all all DT cord-333986-xkx181ek 66 41 three three CD cord-333986-xkx181ek 66 42 categories category NNS cord-333986-xkx181ek 66 43 [ [ -LRB- cord-333986-xkx181ek 66 44 50 50 CD cord-333986-xkx181ek 66 45 ] ] -RRB- cord-333986-xkx181ek 66 46 . . . cord-333986-xkx181ek 67 1 In in IN cord-333986-xkx181ek 67 2 contrast contrast NN cord-333986-xkx181ek 67 3 , , , cord-333986-xkx181ek 67 4 many many JJ cord-333986-xkx181ek 67 5 studies study NNS cord-333986-xkx181ek 67 6 have have VBP cord-333986-xkx181ek 67 7 shown show VBN cord-333986-xkx181ek 67 8 that that IN cord-333986-xkx181ek 67 9 prolonged prolong VBN cord-333986-xkx181ek 67 10 high high JJ cord-333986-xkx181ek 67 11 - - HYPH cord-333986-xkx181ek 67 12 intensity intensity NN cord-333986-xkx181ek 67 13 aerobic aerobic JJ cord-333986-xkx181ek 67 14 exercise exercise NN cord-333986-xkx181ek 67 15 leads lead VBZ cord-333986-xkx181ek 67 16 to to IN cord-333986-xkx181ek 67 17 increased increase VBN cord-333986-xkx181ek 67 18 death death NN cord-333986-xkx181ek 67 19 from from IN cord-333986-xkx181ek 67 20 a a DT cord-333986-xkx181ek 67 21 viral viral JJ cord-333986-xkx181ek 67 22 respiratory respiratory JJ cord-333986-xkx181ek 67 23 infection infection NN cord-333986-xkx181ek 67 24 and and CC cord-333986-xkx181ek 67 25 over over IN cord-333986-xkx181ek 67 26 suppression suppression NN cord-333986-xkx181ek 67 27 of of IN cord-333986-xkx181ek 67 28 the the DT cord-333986-xkx181ek 67 29 immune immune JJ cord-333986-xkx181ek 67 30 response response NN cord-333986-xkx181ek 67 31 [ [ -LRB- cord-333986-xkx181ek 67 32 51 51 CD cord-333986-xkx181ek 67 33 ] ] -RRB- cord-333986-xkx181ek 68 1 [ [ -LRB- cord-333986-xkx181ek 68 2 52 52 CD cord-333986-xkx181ek 68 3 ] ] -RRB- cord-333986-xkx181ek 69 1 [ [ -LRB- cord-333986-xkx181ek 69 2 53 53 CD cord-333986-xkx181ek 69 3 ] ] -RRB- cord-333986-xkx181ek 69 4 . . . cord-333986-xkx181ek 70 1 These these DT cord-333986-xkx181ek 70 2 findings finding NNS cord-333986-xkx181ek 70 3 have have VBP cord-333986-xkx181ek 70 4 led lead VBN cord-333986-xkx181ek 70 5 to to IN cord-333986-xkx181ek 70 6 the the DT cord-333986-xkx181ek 70 7 development development NN cord-333986-xkx181ek 70 8 of of IN cord-333986-xkx181ek 70 9 the the DT cord-333986-xkx181ek 70 10 " " `` cord-333986-xkx181ek 70 11 J J NNP cord-333986-xkx181ek 70 12 - - HYPH cord-333986-xkx181ek 70 13 shaped shape VBN cord-333986-xkx181ek 70 14 " " '' cord-333986-xkx181ek 70 15 hypothesis hypothesis NN cord-333986-xkx181ek 70 16 that that WDT cord-333986-xkx181ek 70 17 articulates articulate VBZ cord-333986-xkx181ek 70 18 this this DT cord-333986-xkx181ek 70 19 balance balance NN cord-333986-xkx181ek 70 20 between between IN cord-333986-xkx181ek 70 21 exercise exercise NN cord-333986-xkx181ek 70 22 dose dose NN cord-333986-xkx181ek 70 23 and and CC cord-333986-xkx181ek 70 24 URTI URTI NNP cord-333986-xkx181ek 70 25 risk risk NN cord-333986-xkx181ek 70 26 ( ( -LRB- cord-333986-xkx181ek 70 27 Figure figure NN cord-333986-xkx181ek 70 28 3 3 CD cord-333986-xkx181ek 70 29 ) ) -RRB- cord-333986-xkx181ek 70 30 . . . cord-333986-xkx181ek 70 31 _SP cord-333986-xkx181ek 71 1 Both both DT cord-333986-xkx181ek 71 2 cross cross JJ cord-333986-xkx181ek 71 3 - - JJ cord-333986-xkx181ek 71 4 sectional sectional JJ cord-333986-xkx181ek 71 5 and and CC cord-333986-xkx181ek 71 6 longitudinal longitudinal JJ cord-333986-xkx181ek 71 7 data datum NNS cord-333986-xkx181ek 71 8 have have VBP cord-333986-xkx181ek 71 9 shown show VBN cord-333986-xkx181ek 71 10 that that IN cord-333986-xkx181ek 71 11 individuals individual NNS cord-333986-xkx181ek 71 12 who who WP cord-333986-xkx181ek 71 13 participate participate VBP cord-333986-xkx181ek 71 14 in in IN cord-333986-xkx181ek 71 15 moderate moderate JJ cord-333986-xkx181ek 71 16 - - HYPH cord-333986-xkx181ek 71 17 intensity intensity NN cord-333986-xkx181ek 71 18 exercise exercise NN cord-333986-xkx181ek 71 19 self self NN cord-333986-xkx181ek 71 20 - - HYPH cord-333986-xkx181ek 71 21 report report VBP cord-333986-xkx181ek 71 22 less less RBR cord-333986-xkx181ek 71 23 upper upper JJ cord-333986-xkx181ek 71 24 respiratory respiratory JJ cord-333986-xkx181ek 71 25 tract tract NN cord-333986-xkx181ek 71 26 infections infection NNS cord-333986-xkx181ek 71 27 ( ( -LRB- cord-333986-xkx181ek 71 28 URTI URTI NNP cord-333986-xkx181ek 71 29 ) ) -RRB- cord-333986-xkx181ek 71 30 . . . cord-333986-xkx181ek 72 1 Additionally additionally RB cord-333986-xkx181ek 72 2 , , , cord-333986-xkx181ek 72 3 in in IN cord-333986-xkx181ek 72 4 animal animal NN cord-333986-xkx181ek 72 5 models model NNS cord-333986-xkx181ek 72 6 , , , cord-333986-xkx181ek 72 7 those those DT cord-333986-xkx181ek 72 8 exposed expose VBN cord-333986-xkx181ek 72 9 to to IN cord-333986-xkx181ek 72 10 moderate moderate JJ cord-333986-xkx181ek 72 11 - - HYPH cord-333986-xkx181ek 72 12 intensity intensity NN cord-333986-xkx181ek 72 13 exercise exercise NN cord-333986-xkx181ek 72 14 before before IN cord-333986-xkx181ek 72 15 symptom symptom NN cord-333986-xkx181ek 72 16 presentation presentation NN cord-333986-xkx181ek 72 17 have have VBP cord-333986-xkx181ek 72 18 lower low JJR cord-333986-xkx181ek 72 19 rates rate NNS cord-333986-xkx181ek 72 20 of of IN cord-333986-xkx181ek 72 21 mortality mortality NN cord-333986-xkx181ek 72 22 [ [ -LRB- cord-333986-xkx181ek 72 23 48 48 CD cord-333986-xkx181ek 72 24 , , , cord-333986-xkx181ek 72 25 49 49 CD cord-333986-xkx181ek 72 26 ] ] -RRB- cord-333986-xkx181ek 72 27 . . . cord-333986-xkx181ek 73 1 A a DT cord-333986-xkx181ek 73 2 prospective prospective JJ cord-333986-xkx181ek 73 3 study study NN cord-333986-xkx181ek 73 4 in in IN cord-333986-xkx181ek 73 5 humans human NNS cord-333986-xkx181ek 73 6 assessing assess VBG cord-333986-xkx181ek 73 7 the the DT cord-333986-xkx181ek 73 8 dose dose JJ cord-333986-xkx181ek 73 9 - - HYPH cord-333986-xkx181ek 73 10 response response NN cord-333986-xkx181ek 73 11 relationship relationship NN cord-333986-xkx181ek 73 12 between between IN cord-333986-xkx181ek 73 13 moderate moderate JJ cord-333986-xkx181ek 73 14 walking walking NN cord-333986-xkx181ek 73 15 / / SYM cord-333986-xkx181ek 73 16 running run VBG cord-333986-xkx181ek 73 17 energy energy NN cord-333986-xkx181ek 73 18 expenditure expenditure NN cord-333986-xkx181ek 73 19 and and CC cord-333986-xkx181ek 73 20 pneumonia pneumonia NN cord-333986-xkx181ek 73 21 , , , cord-333986-xkx181ek 73 22 respiratory respiratory JJ cord-333986-xkx181ek 73 23 disease disease NN cord-333986-xkx181ek 73 24 , , , cord-333986-xkx181ek 73 25 and and CC cord-333986-xkx181ek 73 26 aspiration aspiration NN cord-333986-xkx181ek 73 27 pneumonia pneumonia NN cord-333986-xkx181ek 73 28 mortality mortality NN cord-333986-xkx181ek 73 29 , , , cord-333986-xkx181ek 73 30 found find VBD cord-333986-xkx181ek 73 31 that that IN cord-333986-xkx181ek 73 32 higher high JJR cord-333986-xkx181ek 73 33 doses dose NNS cord-333986-xkx181ek 73 34 of of IN cord-333986-xkx181ek 73 35 moderate moderate JJ cord-333986-xkx181ek 73 36 exercise exercise NN cord-333986-xkx181ek 73 37 decreased decrease VBD cord-333986-xkx181ek 73 38 mortality mortality NN cord-333986-xkx181ek 73 39 in in IN cord-333986-xkx181ek 73 40 all all DT cord-333986-xkx181ek 73 41 three three CD cord-333986-xkx181ek 73 42 categories category NNS cord-333986-xkx181ek 73 43 [ [ -LRB- cord-333986-xkx181ek 73 44 50 50 CD cord-333986-xkx181ek 73 45 ] ] -RRB- cord-333986-xkx181ek 73 46 . . . cord-333986-xkx181ek 74 1 In in IN cord-333986-xkx181ek 74 2 contrast contrast NN cord-333986-xkx181ek 74 3 , , , cord-333986-xkx181ek 74 4 many many JJ cord-333986-xkx181ek 74 5 studies study NNS cord-333986-xkx181ek 74 6 have have VBP cord-333986-xkx181ek 74 7 shown show VBN cord-333986-xkx181ek 74 8 that that IN cord-333986-xkx181ek 74 9 prolonged prolong VBN cord-333986-xkx181ek 74 10 highintensity highintensity NN cord-333986-xkx181ek 74 11 aerobic aerobic JJ cord-333986-xkx181ek 74 12 exercise exercise NN cord-333986-xkx181ek 74 13 leads lead VBZ cord-333986-xkx181ek 74 14 to to IN cord-333986-xkx181ek 74 15 increased increase VBN cord-333986-xkx181ek 74 16 death death NN cord-333986-xkx181ek 74 17 from from IN cord-333986-xkx181ek 74 18 a a DT cord-333986-xkx181ek 74 19 viral viral JJ cord-333986-xkx181ek 74 20 respiratory respiratory JJ cord-333986-xkx181ek 74 21 infection infection NN cord-333986-xkx181ek 74 22 and and CC cord-333986-xkx181ek 74 23 over over IN cord-333986-xkx181ek 74 24 suppression suppression NN cord-333986-xkx181ek 74 25 of of IN cord-333986-xkx181ek 74 26 the the DT cord-333986-xkx181ek 74 27 immune immune JJ cord-333986-xkx181ek 74 28 response response NN cord-333986-xkx181ek 74 29 [ [ -LRB- cord-333986-xkx181ek 74 30 51 51 CD cord-333986-xkx181ek 74 31 ] ] -RRB- cord-333986-xkx181ek 75 1 [ [ -LRB- cord-333986-xkx181ek 75 2 52 52 CD cord-333986-xkx181ek 75 3 ] ] -RRB- cord-333986-xkx181ek 76 1 [ [ -LRB- cord-333986-xkx181ek 76 2 53 53 CD cord-333986-xkx181ek 76 3 ] ] -RRB- cord-333986-xkx181ek 76 4 . . . cord-333986-xkx181ek 77 1 These these DT cord-333986-xkx181ek 77 2 findings finding NNS cord-333986-xkx181ek 77 3 have have VBP cord-333986-xkx181ek 77 4 led lead VBN cord-333986-xkx181ek 77 5 to to IN cord-333986-xkx181ek 77 6 the the DT cord-333986-xkx181ek 77 7 development development NN cord-333986-xkx181ek 77 8 of of IN cord-333986-xkx181ek 77 9 the the DT cord-333986-xkx181ek 77 10 " " `` cord-333986-xkx181ek 77 11 Jshaped Jshaped NNP cord-333986-xkx181ek 77 12 " " '' cord-333986-xkx181ek 77 13 hypothesis hypothesis NN cord-333986-xkx181ek 77 14 that that WDT cord-333986-xkx181ek 77 15 articulates articulate VBZ cord-333986-xkx181ek 77 16 this this DT cord-333986-xkx181ek 77 17 balance balance NN cord-333986-xkx181ek 77 18 between between IN cord-333986-xkx181ek 77 19 exercise exercise NN cord-333986-xkx181ek 77 20 dose dose NN cord-333986-xkx181ek 77 21 and and CC cord-333986-xkx181ek 77 22 URTI URTI NNP cord-333986-xkx181ek 77 23 risk risk NN cord-333986-xkx181ek 77 24 ( ( -LRB- cord-333986-xkx181ek 77 25 Figure figure NN cord-333986-xkx181ek 77 26 3 3 CD cord-333986-xkx181ek 77 27 ) ) -RRB- cord-333986-xkx181ek 77 28 . . . cord-333986-xkx181ek 78 1 The the DT cord-333986-xkx181ek 78 2 actions action NNS cord-333986-xkx181ek 78 3 of of IN cord-333986-xkx181ek 78 4 cytokines cytokine NNS cord-333986-xkx181ek 78 5 are be VBP cord-333986-xkx181ek 78 6 contained contain VBN cord-333986-xkx181ek 78 7 within within IN cord-333986-xkx181ek 78 8 two two CD cord-333986-xkx181ek 78 9 broad broad JJ cord-333986-xkx181ek 78 10 categories category NNS cord-333986-xkx181ek 78 11 , , , cord-333986-xkx181ek 78 12 either either CC cord-333986-xkx181ek 78 13 a a DT cord-333986-xkx181ek 78 14 pro pro JJ cord-333986-xkx181ek 78 15 - - JJ cord-333986-xkx181ek 78 16 inflammatory inflammatory JJ cord-333986-xkx181ek 78 17 or or CC cord-333986-xkx181ek 78 18 anti anti JJ cord-333986-xkx181ek 78 19 - - JJ cord-333986-xkx181ek 78 20 inflammatory inflammatory JJ cord-333986-xkx181ek 78 21 induction induction NN cord-333986-xkx181ek 78 22 based base VBN cord-333986-xkx181ek 78 23 on on IN cord-333986-xkx181ek 78 24 highly highly RB cord-333986-xkx181ek 78 25 coordinated coordinate VBN cord-333986-xkx181ek 78 26 immune immune JJ cord-333986-xkx181ek 78 27 - - HYPH cord-333986-xkx181ek 78 28 stimulatory stimulatory JJ cord-333986-xkx181ek 78 29 responses response NNS cord-333986-xkx181ek 78 30 [ [ -LRB- cord-333986-xkx181ek 78 31 54 54 CD cord-333986-xkx181ek 78 32 ] ] -RRB- cord-333986-xkx181ek 78 33 . . . cord-333986-xkx181ek 79 1 A a DT cord-333986-xkx181ek 79 2 common common JJ cord-333986-xkx181ek 79 3 theme theme NN cord-333986-xkx181ek 79 4 across across IN cord-333986-xkx181ek 79 5 groups group NNS cord-333986-xkx181ek 79 6 , , , cord-333986-xkx181ek 79 7 though though RB cord-333986-xkx181ek 79 8 , , , cord-333986-xkx181ek 79 9 is be VBZ cord-333986-xkx181ek 79 10 that that IN cord-333986-xkx181ek 79 11 an an DT cord-333986-xkx181ek 79 12 increased increase VBN cord-333986-xkx181ek 79 13 level level NN cord-333986-xkx181ek 79 14 of of IN cord-333986-xkx181ek 79 15 fitness fitness NN cord-333986-xkx181ek 79 16 due due JJ cord-333986-xkx181ek 79 17 to to IN cord-333986-xkx181ek 79 18 exercise exercise VB cord-333986-xkx181ek 79 19 training training NN cord-333986-xkx181ek 79 20 is be VBZ cord-333986-xkx181ek 79 21 associated associate VBN cord-333986-xkx181ek 79 22 with with IN cord-333986-xkx181ek 79 23 lower low JJR cord-333986-xkx181ek 79 24 circulating circulate VBG cord-333986-xkx181ek 79 25 concentrations concentration NNS cord-333986-xkx181ek 79 26 of of IN cord-333986-xkx181ek 79 27 pro pro JJ cord-333986-xkx181ek 79 28 - - JJ cord-333986-xkx181ek 79 29 inflammatory inflammatory JJ cord-333986-xkx181ek 79 30 cytokines cytokine NNS cord-333986-xkx181ek 79 31 and and CC cord-333986-xkx181ek 79 32 higher high JJR cord-333986-xkx181ek 79 33 circulating circulate VBG cord-333986-xkx181ek 79 34 concentration concentration NN cord-333986-xkx181ek 79 35 of of IN cord-333986-xkx181ek 79 36 anti anti JJ cord-333986-xkx181ek 79 37 - - JJ cord-333986-xkx181ek 79 38 inflammatory inflammatory JJ cord-333986-xkx181ek 79 39 cytokines cytokine NNS cord-333986-xkx181ek 79 40 [ [ -LRB- cord-333986-xkx181ek 79 41 55 55 CD cord-333986-xkx181ek 79 42 ] ] -RRB- cord-333986-xkx181ek 79 43 . . . cord-333986-xkx181ek 80 1 IL-6 IL-6 NNP cord-333986-xkx181ek 80 2 is be VBZ cord-333986-xkx181ek 80 3 explicitly explicitly RB cord-333986-xkx181ek 80 4 associated associate VBN cord-333986-xkx181ek 80 5 with with IN cord-333986-xkx181ek 80 6 higher high JJR cord-333986-xkx181ek 80 7 than than IN cord-333986-xkx181ek 80 8 baseline baseline JJ cord-333986-xkx181ek 80 9 levels level NNS cord-333986-xkx181ek 80 10 of of IN cord-333986-xkx181ek 80 11 skeletal skeletal JJ cord-333986-xkx181ek 80 12 muscle muscle NN cord-333986-xkx181ek 80 13 production production NN cord-333986-xkx181ek 80 14 following follow VBG cord-333986-xkx181ek 80 15 prolonged prolong VBN cord-333986-xkx181ek 80 16 exercise exercise NN cord-333986-xkx181ek 80 17 , , , cord-333986-xkx181ek 80 18 though though IN cord-333986-xkx181ek 80 19 exercise exercise NN cord-333986-xkx181ek 80 20 duration duration NN cord-333986-xkx181ek 80 21 is be VBZ cord-333986-xkx181ek 80 22 a a DT cord-333986-xkx181ek 80 23 critical critical JJ cord-333986-xkx181ek 80 24 factor factor NN cord-333986-xkx181ek 80 25 in in IN cord-333986-xkx181ek 80 26 determining determine VBG cord-333986-xkx181ek 80 27 postexercise postexercise NN cord-333986-xkx181ek 80 28 plasma plasma NN cord-333986-xkx181ek 80 29 IL-6 IL-6 NNP cord-333986-xkx181ek 80 30 amplitude amplitude NN cord-333986-xkx181ek 80 31 [ [ -LRB- cord-333986-xkx181ek 80 32 56 56 CD cord-333986-xkx181ek 80 33 ] ] -RRB- cord-333986-xkx181ek 80 34 [ [ -LRB- cord-333986-xkx181ek 80 35 57 57 CD cord-333986-xkx181ek 80 36 ] ] -RRB- cord-333986-xkx181ek 80 37 [ [ -LRB- cord-333986-xkx181ek 80 38 58 58 CD cord-333986-xkx181ek 80 39 ] ] -RRB- cord-333986-xkx181ek 80 40 [ [ -LRB- cord-333986-xkx181ek 80 41 59 59 CD cord-333986-xkx181ek 80 42 ] ] -RRB- cord-333986-xkx181ek 80 43 . . . cord-333986-xkx181ek 81 1 In in IN cord-333986-xkx181ek 81 2 humans human NNS cord-333986-xkx181ek 81 3 , , , cord-333986-xkx181ek 81 4 the the DT cord-333986-xkx181ek 81 5 infusion infusion NN cord-333986-xkx181ek 81 6 of of IN cord-333986-xkx181ek 81 7 IL-6 IL-6 NNP cord-333986-xkx181ek 81 8 increases increase VBZ cord-333986-xkx181ek 81 9 levels level NNS cord-333986-xkx181ek 81 10 of of IN cord-333986-xkx181ek 81 11 known know VBN cord-333986-xkx181ek 81 12 anti anti JJ cord-333986-xkx181ek 81 13 - - JJ cord-333986-xkx181ek 81 14 inflammatory inflammatory JJ cord-333986-xkx181ek 81 15 modulators modulator NNS cord-333986-xkx181ek 81 16 such such JJ cord-333986-xkx181ek 81 17 as as IN cord-333986-xkx181ek 81 18 plasma plasma NN cord-333986-xkx181ek 81 19 cortisol cortisol NN cord-333986-xkx181ek 81 20 , , , cord-333986-xkx181ek 81 21 IL-1 IL-1 NNP cord-333986-xkx181ek 81 22 receptor receptor NN cord-333986-xkx181ek 81 23 antagonist antagonist NN cord-333986-xkx181ek 81 24 , , , cord-333986-xkx181ek 81 25 and and CC cord-333986-xkx181ek 81 26 IL-10 IL-10 NNP cord-333986-xkx181ek 81 27 . . . cord-333986-xkx181ek 82 1 It -PRON- PRP cord-333986-xkx181ek 82 2 also also RB cord-333986-xkx181ek 82 3 attenuates attenuate VBZ cord-333986-xkx181ek 82 4 LPS LPS NNP cord-333986-xkx181ek 82 5 - - HYPH cord-333986-xkx181ek 82 6 stimulated stimulate VBN cord-333986-xkx181ek 82 7 production production NN cord-333986-xkx181ek 82 8 of of IN cord-333986-xkx181ek 82 9 the the DT cord-333986-xkx181ek 82 10 proinflammatory proinflammatory JJ cord-333986-xkx181ek 82 11 cytokine cytokine NN cord-333986-xkx181ek 82 12 TNF tnf NN cord-333986-xkx181ek 82 13 - - HYPH cord-333986-xkx181ek 82 14 α α NN cord-333986-xkx181ek 82 15 in in IN cord-333986-xkx181ek 82 16 both both DT cord-333986-xkx181ek 82 17 cultured cultured JJ cord-333986-xkx181ek 82 18 monocytes monocyte NNS cord-333986-xkx181ek 82 19 and and CC cord-333986-xkx181ek 82 20 in in IN cord-333986-xkx181ek 82 21 vivo vivo NN cord-333986-xkx181ek 82 22 in in IN cord-333986-xkx181ek 82 23 humans human NNS cord-333986-xkx181ek 82 24 [ [ -LRB- cord-333986-xkx181ek 82 25 58 58 CD cord-333986-xkx181ek 82 26 ] ] -RRB- cord-333986-xkx181ek 82 27 [ [ -LRB- cord-333986-xkx181ek 82 28 59 59 CD cord-333986-xkx181ek 82 29 ] ] -RRB- cord-333986-xkx181ek 82 30 [ [ -LRB- cord-333986-xkx181ek 82 31 60 60 CD cord-333986-xkx181ek 82 32 ] ] -RRB- cord-333986-xkx181ek 82 33 [ [ -LRB- cord-333986-xkx181ek 82 34 61 61 CD cord-333986-xkx181ek 82 35 ] ] -RRB- cord-333986-xkx181ek 82 36 . . . cord-333986-xkx181ek 83 1 The the DT cord-333986-xkx181ek 83 2 cells cell NNS cord-333986-xkx181ek 83 3 of of IN cord-333986-xkx181ek 83 4 the the DT cord-333986-xkx181ek 83 5 innate innate JJ cord-333986-xkx181ek 83 6 immune immune JJ cord-333986-xkx181ek 83 7 system system NN cord-333986-xkx181ek 83 8 express express VBP cord-333986-xkx181ek 83 9 various various JJ cord-333986-xkx181ek 83 10 pattern pattern NN cord-333986-xkx181ek 83 11 recognition recognition NN cord-333986-xkx181ek 83 12 receptors receptor NNS cord-333986-xkx181ek 83 13 ( ( -LRB- cord-333986-xkx181ek 83 14 PRRs PRRs NNP cord-333986-xkx181ek 83 15 ) ) -RRB- cord-333986-xkx181ek 83 16 that that WDT cord-333986-xkx181ek 83 17 recognize recognize VBP cord-333986-xkx181ek 83 18 specific specific JJ cord-333986-xkx181ek 83 19 pathogen pathogen NN cord-333986-xkx181ek 83 20 - - HYPH cord-333986-xkx181ek 83 21 associated associate VBN cord-333986-xkx181ek 83 22 molecular molecular JJ cord-333986-xkx181ek 83 23 patterns pattern NNS cord-333986-xkx181ek 83 24 ( ( -LRB- cord-333986-xkx181ek 83 25 PAMPs pamp NNS cord-333986-xkx181ek 83 26 ) ) -RRB- cord-333986-xkx181ek 83 27 to to TO cord-333986-xkx181ek 83 28 mount mount VB cord-333986-xkx181ek 83 29 a a DT cord-333986-xkx181ek 83 30 highly highly RB cord-333986-xkx181ek 83 31 coordinated coordinated JJ cord-333986-xkx181ek 83 32 immune immune JJ cord-333986-xkx181ek 83 33 response response NN cord-333986-xkx181ek 83 34 [ [ -LRB- cord-333986-xkx181ek 83 35 62 62 CD cord-333986-xkx181ek 83 36 ] ] -RRB- cord-333986-xkx181ek 83 37 . . . cord-333986-xkx181ek 84 1 Toll toll NN cord-333986-xkx181ek 84 2 - - HYPH cord-333986-xkx181ek 84 3 like like JJ cord-333986-xkx181ek 84 4 Receptors receptor NNS cord-333986-xkx181ek 84 5 ( ( -LRB- cord-333986-xkx181ek 84 6 TLRs TLRs NNP cord-333986-xkx181ek 84 7 ) ) -RRB- cord-333986-xkx181ek 84 8 are be VBP cord-333986-xkx181ek 84 9 a a DT cord-333986-xkx181ek 84 10 type type NN cord-333986-xkx181ek 84 11 of of IN cord-333986-xkx181ek 84 12 PRR PRR NNP cord-333986-xkx181ek 84 13 that that WDT cord-333986-xkx181ek 84 14 can can MD cord-333986-xkx181ek 84 15 be be VB cord-333986-xkx181ek 84 16 found find VBN cord-333986-xkx181ek 84 17 on on IN cord-333986-xkx181ek 84 18 the the DT cord-333986-xkx181ek 84 19 cells cell NNS cord-333986-xkx181ek 84 20 of of IN cord-333986-xkx181ek 84 21 the the DT cord-333986-xkx181ek 84 22 innate innate JJ cord-333986-xkx181ek 84 23 immune immune JJ cord-333986-xkx181ek 84 24 system system NN cord-333986-xkx181ek 84 25 ( ( -LRB- cord-333986-xkx181ek 84 26 monocytes monocyte NNS cord-333986-xkx181ek 84 27 / / SYM cord-333986-xkx181ek 84 28 macrophages macrophage NNS cord-333986-xkx181ek 84 29 , , , cord-333986-xkx181ek 84 30 neutrophils neutrophil NNS cord-333986-xkx181ek 84 31 , , , cord-333986-xkx181ek 84 32 dendritic dendritic JJ cord-333986-xkx181ek 84 33 cells cell NNS cord-333986-xkx181ek 84 34 , , , cord-333986-xkx181ek 84 35 and and CC cord-333986-xkx181ek 84 36 natural natural JJ cord-333986-xkx181ek 84 37 killer killer NN cord-333986-xkx181ek 84 38 cells cell NNS cord-333986-xkx181ek 84 39 ) ) -RRB- cord-333986-xkx181ek 84 40 , , , cord-333986-xkx181ek 84 41 playing play VBG cord-333986-xkx181ek 84 42 a a DT cord-333986-xkx181ek 84 43 significant significant JJ cord-333986-xkx181ek 84 44 role role NN cord-333986-xkx181ek 84 45 in in IN cord-333986-xkx181ek 84 46 the the DT cord-333986-xkx181ek 84 47 induction induction NN cord-333986-xkx181ek 84 48 of of IN cord-333986-xkx181ek 84 49 a a DT cord-333986-xkx181ek 84 50 pro pro JJ cord-333986-xkx181ek 84 51 - - JJ cord-333986-xkx181ek 84 52 inflammatory inflammatory JJ cord-333986-xkx181ek 84 53 immune immune JJ cord-333986-xkx181ek 84 54 response response NN cord-333986-xkx181ek 84 55 [ [ -LRB- cord-333986-xkx181ek 84 56 62 62 CD cord-333986-xkx181ek 84 57 ] ] -RRB- cord-333986-xkx181ek 84 58 . . . cord-333986-xkx181ek 85 1 Interestingly interestingly RB cord-333986-xkx181ek 85 2 , , , cord-333986-xkx181ek 85 3 Flynn Flynn NNP cord-333986-xkx181ek 85 4 et et NNP cord-333986-xkx181ek 85 5 al al NNP cord-333986-xkx181ek 85 6 . . NNP cord-333986-xkx181ek 85 7 , , , cord-333986-xkx181ek 85 8 showed show VBD cord-333986-xkx181ek 85 9 that that IN cord-333986-xkx181ek 85 10 there there EX cord-333986-xkx181ek 85 11 was be VBD cord-333986-xkx181ek 85 12 a a DT cord-333986-xkx181ek 85 13 blunted blunted JJ cord-333986-xkx181ek 85 14 response response NN cord-333986-xkx181ek 85 15 of of IN cord-333986-xkx181ek 85 16 LPS LPS NNP cord-333986-xkx181ek 85 17 - - HYPH cord-333986-xkx181ek 85 18 stimulated stimulate VBN cord-333986-xkx181ek 85 19 blood blood NN cord-333986-xkx181ek 85 20 cultures culture NNS cord-333986-xkx181ek 85 21 collected collect VBN cord-333986-xkx181ek 85 22 from from IN cord-333986-xkx181ek 85 23 older old JJR cord-333986-xkx181ek 85 24 women woman NNS cord-333986-xkx181ek 85 25 following follow VBG cord-333986-xkx181ek 85 26 ten ten CD cord-333986-xkx181ek 85 27 weeks week NNS cord-333986-xkx181ek 85 28 of of IN cord-333986-xkx181ek 85 29 resistive resistive JJ cord-333986-xkx181ek 85 30 exercise exercise NN cord-333986-xkx181ek 85 31 training training NN cord-333986-xkx181ek 85 32 [ [ -LRB- cord-333986-xkx181ek 85 33 63 63 CD cord-333986-xkx181ek 85 34 , , , cord-333986-xkx181ek 85 35 64 64 CD cord-333986-xkx181ek 85 36 ] ] -RRB- cord-333986-xkx181ek 85 37 . . . cord-333986-xkx181ek 86 1 TLR4 TLR4 NNP cord-333986-xkx181ek 86 2 mRNA mrna NN cord-333986-xkx181ek 86 3 was be VBD cord-333986-xkx181ek 86 4 lower low JJR cord-333986-xkx181ek 86 5 in in IN cord-333986-xkx181ek 86 6 the the DT cord-333986-xkx181ek 86 7 women woman NNS cord-333986-xkx181ek 86 8 who who WP cord-333986-xkx181ek 86 9 participated participate VBD cord-333986-xkx181ek 86 10 in in IN cord-333986-xkx181ek 86 11 the the DT cord-333986-xkx181ek 86 12 training training NN cord-333986-xkx181ek 86 13 versus versus IN cord-333986-xkx181ek 86 14 the the DT cord-333986-xkx181ek 86 15 women woman NNS cord-333986-xkx181ek 86 16 who who WP cord-333986-xkx181ek 86 17 did do VBD cord-333986-xkx181ek 86 18 not not RB cord-333986-xkx181ek 86 19 [ [ -LRB- cord-333986-xkx181ek 86 20 63 63 CD cord-333986-xkx181ek 86 21 , , , cord-333986-xkx181ek 86 22 64 64 CD cord-333986-xkx181ek 86 23 ] ] -RRB- cord-333986-xkx181ek 86 24 . . . cord-333986-xkx181ek 87 1 Further further JJ cord-333986-xkx181ek 87 2 studies study NNS cord-333986-xkx181ek 87 3 have have VBP cord-333986-xkx181ek 87 4 been be VBN cord-333986-xkx181ek 87 5 conducted conduct VBN cord-333986-xkx181ek 87 6 in in IN cord-333986-xkx181ek 87 7 elderly elderly JJ cord-333986-xkx181ek 87 8 populations population NNS cord-333986-xkx181ek 87 9 , , , cord-333986-xkx181ek 87 10 showing show VBG cord-333986-xkx181ek 87 11 a a DT cord-333986-xkx181ek 87 12 reduction reduction NN cord-333986-xkx181ek 87 13 in in IN cord-333986-xkx181ek 87 14 both both DT cord-333986-xkx181ek 87 15 TLR2 TLR2 NNP cord-333986-xkx181ek 87 16 and and CC cord-333986-xkx181ek 87 17 TLR4 TLR4 NNP cord-333986-xkx181ek 87 18 protein protein NN cord-333986-xkx181ek 87 19 following follow VBG cord-333986-xkx181ek 87 20 resistance resistance NN cord-333986-xkx181ek 87 21 - - HYPH cord-333986-xkx181ek 87 22 training training NN cord-333986-xkx181ek 87 23 programs program NNS cord-333986-xkx181ek 87 24 . . . cord-333986-xkx181ek 88 1 Collectively collectively RB cord-333986-xkx181ek 88 2 , , , cord-333986-xkx181ek 88 3 these these DT cord-333986-xkx181ek 88 4 findings finding NNS cord-333986-xkx181ek 88 5 provide provide VBP cord-333986-xkx181ek 88 6 additional additional JJ cord-333986-xkx181ek 88 7 evidence evidence NN cord-333986-xkx181ek 88 8 for for IN cord-333986-xkx181ek 88 9 an an DT cord-333986-xkx181ek 88 10 exercise exercise NN cord-333986-xkx181ek 88 11 - - HYPH cord-333986-xkx181ek 88 12 induced induce VBN cord-333986-xkx181ek 88 13 anti anti JJ cord-333986-xkx181ek 88 14 - - JJ cord-333986-xkx181ek 88 15 inflammatory inflammatory JJ cord-333986-xkx181ek 88 16 status status NN cord-333986-xkx181ek 88 17 . . . cord-333986-xkx181ek 89 1 As as IN cord-333986-xkx181ek 89 2 mentioned mention VBN cord-333986-xkx181ek 89 3 in in IN cord-333986-xkx181ek 89 4 Figure figure NN cord-333986-xkx181ek 89 5 1 1 CD cord-333986-xkx181ek 89 6 , , , cord-333986-xkx181ek 89 7 exercise exercise NN cord-333986-xkx181ek 89 8 promotes promote VBZ cord-333986-xkx181ek 89 9 some some DT cord-333986-xkx181ek 89 10 wide wide RB cord-333986-xkx181ek 89 11 - - HYPH cord-333986-xkx181ek 89 12 ranging range VBG cord-333986-xkx181ek 89 13 changes change NNS cord-333986-xkx181ek 89 14 in in IN cord-333986-xkx181ek 89 15 both both DT cord-333986-xkx181ek 89 16 innate innate JJ cord-333986-xkx181ek 89 17 and and CC cord-333986-xkx181ek 89 18 adaptive adaptive JJ cord-333986-xkx181ek 89 19 cells cell NNS cord-333986-xkx181ek 89 20 , , , cord-333986-xkx181ek 89 21 including include VBG cord-333986-xkx181ek 89 22 increased increase VBN cord-333986-xkx181ek 89 23 phagocytic phagocytic JJ cord-333986-xkx181ek 89 24 cell cell NN cord-333986-xkx181ek 89 25 action action NN cord-333986-xkx181ek 89 26 , , , cord-333986-xkx181ek 89 27 increased increase VBD cord-333986-xkx181ek 89 28 T t NN cord-333986-xkx181ek 89 29 cell cell NN cord-333986-xkx181ek 89 30 proliferation proliferation NN cord-333986-xkx181ek 89 31 , , , cord-333986-xkx181ek 89 32 and and CC cord-333986-xkx181ek 89 33 redistribution redistribution NN cord-333986-xkx181ek 89 34 of of IN cord-333986-xkx181ek 89 35 lymphocytes lymphocyte NNS cord-333986-xkx181ek 89 36 to to TO cord-333986-xkx181ek 89 37 further further RB cord-333986-xkx181ek 89 38 strengthen strengthen VB cord-333986-xkx181ek 89 39 the the DT cord-333986-xkx181ek 89 40 defense defense NN cord-333986-xkx181ek 89 41 system system NN cord-333986-xkx181ek 89 42 [ [ -LRB- cord-333986-xkx181ek 89 43 27 27 CD cord-333986-xkx181ek 89 44 ] ] -RRB- cord-333986-xkx181ek 89 45 . . . cord-333986-xkx181ek 90 1 Lowder Lowder NNP cord-333986-xkx181ek 90 2 et et NNP cord-333986-xkx181ek 90 3 al al NNP cord-333986-xkx181ek 90 4 . . . cord-333986-xkx181ek 90 5 investigated investigate VBD cord-333986-xkx181ek 90 6 the the DT cord-333986-xkx181ek 90 7 immunologic immunologic JJ cord-333986-xkx181ek 90 8 mechanism mechanism NN cord-333986-xkx181ek 90 9 as as IN cord-333986-xkx181ek 90 10 to to IN cord-333986-xkx181ek 90 11 why why WRB cord-333986-xkx181ek 90 12 moderate moderate JJ cord-333986-xkx181ek 90 13 - - HYPH cord-333986-xkx181ek 90 14 intensity intensity NN cord-333986-xkx181ek 90 15 exercise exercise NN cord-333986-xkx181ek 90 16 produces produce VBZ cord-333986-xkx181ek 90 17 the the DT cord-333986-xkx181ek 90 18 most most RBS cord-333986-xkx181ek 90 19 beneficial beneficial JJ cord-333986-xkx181ek 90 20 health health NN cord-333986-xkx181ek 90 21 response response NN cord-333986-xkx181ek 90 22 [ [ -LRB- cord-333986-xkx181ek 90 23 53 53 CD cord-333986-xkx181ek 90 24 ] ] -RRB- cord-333986-xkx181ek 90 25 . . . cord-333986-xkx181ek 91 1 In in IN cord-333986-xkx181ek 91 2 the the DT cord-333986-xkx181ek 91 3 study study NN cord-333986-xkx181ek 91 4 , , , cord-333986-xkx181ek 91 5 mice mouse NNS cord-333986-xkx181ek 91 6 that that WDT cord-333986-xkx181ek 91 7 performed perform VBD cord-333986-xkx181ek 91 8 20 20 CD cord-333986-xkx181ek 91 9 - - SYM cord-333986-xkx181ek 91 10 30 30 CD cord-333986-xkx181ek 91 11 min min NN cord-333986-xkx181ek 91 12 of of IN cord-333986-xkx181ek 91 13 moderate moderate JJ cord-333986-xkx181ek 91 14 - - HYPH cord-333986-xkx181ek 91 15 intensity intensity NN cord-333986-xkx181ek 92 1 The the DT cord-333986-xkx181ek 92 2 actions action NNS cord-333986-xkx181ek 92 3 of of IN cord-333986-xkx181ek 92 4 cytokines cytokine NNS cord-333986-xkx181ek 92 5 are be VBP cord-333986-xkx181ek 92 6 contained contain VBN cord-333986-xkx181ek 92 7 within within IN cord-333986-xkx181ek 92 8 two two CD cord-333986-xkx181ek 92 9 broad broad JJ cord-333986-xkx181ek 92 10 categories category NNS cord-333986-xkx181ek 92 11 , , , cord-333986-xkx181ek 92 12 either either CC cord-333986-xkx181ek 92 13 a a DT cord-333986-xkx181ek 92 14 pro pro JJ cord-333986-xkx181ek 92 15 - - JJ cord-333986-xkx181ek 92 16 inflammatory inflammatory JJ cord-333986-xkx181ek 92 17 or or CC cord-333986-xkx181ek 92 18 anti anti JJ cord-333986-xkx181ek 92 19 - - JJ cord-333986-xkx181ek 92 20 inflammatory inflammatory JJ cord-333986-xkx181ek 92 21 induction induction NN cord-333986-xkx181ek 92 22 based base VBN cord-333986-xkx181ek 92 23 on on IN cord-333986-xkx181ek 92 24 highly highly RB cord-333986-xkx181ek 92 25 coordinated coordinate VBN cord-333986-xkx181ek 92 26 immune immune JJ cord-333986-xkx181ek 92 27 - - HYPH cord-333986-xkx181ek 92 28 stimulatory stimulatory JJ cord-333986-xkx181ek 92 29 responses response NNS cord-333986-xkx181ek 92 30 [ [ -LRB- cord-333986-xkx181ek 92 31 54 54 CD cord-333986-xkx181ek 92 32 ] ] -RRB- cord-333986-xkx181ek 92 33 . . . cord-333986-xkx181ek 93 1 A a DT cord-333986-xkx181ek 93 2 common common JJ cord-333986-xkx181ek 93 3 theme theme NN cord-333986-xkx181ek 93 4 across across IN cord-333986-xkx181ek 93 5 groups group NNS cord-333986-xkx181ek 93 6 , , , cord-333986-xkx181ek 93 7 though though RB cord-333986-xkx181ek 93 8 , , , cord-333986-xkx181ek 93 9 is be VBZ cord-333986-xkx181ek 93 10 that that IN cord-333986-xkx181ek 93 11 an an DT cord-333986-xkx181ek 93 12 increased increase VBN cord-333986-xkx181ek 93 13 level level NN cord-333986-xkx181ek 93 14 of of IN cord-333986-xkx181ek 93 15 fitness fitness NN cord-333986-xkx181ek 93 16 due due JJ cord-333986-xkx181ek 93 17 to to IN cord-333986-xkx181ek 93 18 exercise exercise VB cord-333986-xkx181ek 93 19 training training NN cord-333986-xkx181ek 93 20 is be VBZ cord-333986-xkx181ek 93 21 associated associate VBN cord-333986-xkx181ek 93 22 with with IN cord-333986-xkx181ek 93 23 lower low JJR cord-333986-xkx181ek 93 24 circulating circulate VBG cord-333986-xkx181ek 93 25 concentrations concentration NNS cord-333986-xkx181ek 93 26 of of IN cord-333986-xkx181ek 93 27 pro pro JJ cord-333986-xkx181ek 93 28 - - JJ cord-333986-xkx181ek 93 29 inflammatory inflammatory JJ cord-333986-xkx181ek 93 30 cytokines cytokine NNS cord-333986-xkx181ek 93 31 and and CC cord-333986-xkx181ek 93 32 higher high JJR cord-333986-xkx181ek 93 33 circulating circulate VBG cord-333986-xkx181ek 93 34 concentration concentration NN cord-333986-xkx181ek 93 35 of of IN cord-333986-xkx181ek 93 36 anti anti JJ cord-333986-xkx181ek 93 37 - - JJ cord-333986-xkx181ek 93 38 inflammatory inflammatory JJ cord-333986-xkx181ek 93 39 cytokines cytokine NNS cord-333986-xkx181ek 93 40 [ [ -LRB- cord-333986-xkx181ek 93 41 55 55 CD cord-333986-xkx181ek 93 42 ] ] -RRB- cord-333986-xkx181ek 93 43 . . . cord-333986-xkx181ek 94 1 IL-6 IL-6 NNP cord-333986-xkx181ek 94 2 is be VBZ cord-333986-xkx181ek 94 3 explicitly explicitly RB cord-333986-xkx181ek 94 4 associated associate VBN cord-333986-xkx181ek 94 5 with with IN cord-333986-xkx181ek 94 6 higher high JJR cord-333986-xkx181ek 94 7 than than IN cord-333986-xkx181ek 94 8 baseline baseline JJ cord-333986-xkx181ek 94 9 levels level NNS cord-333986-xkx181ek 94 10 of of IN cord-333986-xkx181ek 94 11 skeletal skeletal JJ cord-333986-xkx181ek 94 12 muscle muscle NN cord-333986-xkx181ek 94 13 production production NN cord-333986-xkx181ek 94 14 following follow VBG cord-333986-xkx181ek 94 15 prolonged prolong VBN cord-333986-xkx181ek 94 16 exercise exercise NN cord-333986-xkx181ek 94 17 , , , cord-333986-xkx181ek 94 18 though though IN cord-333986-xkx181ek 94 19 exercise exercise NN cord-333986-xkx181ek 94 20 duration duration NN cord-333986-xkx181ek 94 21 is be VBZ cord-333986-xkx181ek 94 22 a a DT cord-333986-xkx181ek 94 23 critical critical JJ cord-333986-xkx181ek 94 24 factor factor NN cord-333986-xkx181ek 94 25 in in IN cord-333986-xkx181ek 94 26 determining determine VBG cord-333986-xkx181ek 94 27 postexercise postexercise NN cord-333986-xkx181ek 94 28 plasma plasma NN cord-333986-xkx181ek 94 29 IL-6 IL-6 NNP cord-333986-xkx181ek 94 30 amplitude amplitude NN cord-333986-xkx181ek 94 31 [ [ -LRB- cord-333986-xkx181ek 94 32 56 56 CD cord-333986-xkx181ek 94 33 ] ] -RRB- cord-333986-xkx181ek 94 34 [ [ -LRB- cord-333986-xkx181ek 94 35 57 57 CD cord-333986-xkx181ek 94 36 ] ] -RRB- cord-333986-xkx181ek 94 37 [ [ -LRB- cord-333986-xkx181ek 94 38 58 58 CD cord-333986-xkx181ek 94 39 ] ] -RRB- cord-333986-xkx181ek 94 40 [ [ -LRB- cord-333986-xkx181ek 94 41 59 59 CD cord-333986-xkx181ek 94 42 ] ] -RRB- cord-333986-xkx181ek 94 43 . . . cord-333986-xkx181ek 95 1 In in IN cord-333986-xkx181ek 95 2 humans human NNS cord-333986-xkx181ek 95 3 , , , cord-333986-xkx181ek 95 4 the the DT cord-333986-xkx181ek 95 5 infusion infusion NN cord-333986-xkx181ek 95 6 of of IN cord-333986-xkx181ek 95 7 IL-6 IL-6 NNP cord-333986-xkx181ek 95 8 increases increase VBZ cord-333986-xkx181ek 95 9 levels level NNS cord-333986-xkx181ek 95 10 of of IN cord-333986-xkx181ek 95 11 known know VBN cord-333986-xkx181ek 95 12 anti anti JJ cord-333986-xkx181ek 95 13 - - JJ cord-333986-xkx181ek 95 14 inflammatory inflammatory JJ cord-333986-xkx181ek 95 15 modulators modulator NNS cord-333986-xkx181ek 95 16 such such JJ cord-333986-xkx181ek 95 17 as as IN cord-333986-xkx181ek 95 18 plasma plasma NN cord-333986-xkx181ek 95 19 cortisol cortisol NN cord-333986-xkx181ek 95 20 , , , cord-333986-xkx181ek 95 21 IL-1 IL-1 NNP cord-333986-xkx181ek 95 22 receptor receptor NN cord-333986-xkx181ek 95 23 antagonist antagonist NN cord-333986-xkx181ek 95 24 , , , cord-333986-xkx181ek 95 25 and and CC cord-333986-xkx181ek 95 26 IL-10 IL-10 NNP cord-333986-xkx181ek 95 27 . . . cord-333986-xkx181ek 96 1 It -PRON- PRP cord-333986-xkx181ek 96 2 also also RB cord-333986-xkx181ek 96 3 attenuates attenuate VBZ cord-333986-xkx181ek 96 4 LPS LPS NNP cord-333986-xkx181ek 96 5 - - HYPH cord-333986-xkx181ek 96 6 stimulated stimulate VBN cord-333986-xkx181ek 96 7 production production NN cord-333986-xkx181ek 96 8 of of IN cord-333986-xkx181ek 96 9 the the DT cord-333986-xkx181ek 96 10 pro pro JJ cord-333986-xkx181ek 96 11 - - JJ cord-333986-xkx181ek 96 12 inflammatory inflammatory JJ cord-333986-xkx181ek 96 13 cytokine cytokine NN cord-333986-xkx181ek 96 14 TNF tnf NN cord-333986-xkx181ek 96 15 - - HYPH cord-333986-xkx181ek 96 16 α α NN cord-333986-xkx181ek 96 17 in in IN cord-333986-xkx181ek 96 18 both both DT cord-333986-xkx181ek 96 19 cultured cultured JJ cord-333986-xkx181ek 96 20 monocytes monocyte NNS cord-333986-xkx181ek 96 21 and and CC cord-333986-xkx181ek 96 22 in in IN cord-333986-xkx181ek 96 23 vivo vivo NN cord-333986-xkx181ek 96 24 in in IN cord-333986-xkx181ek 96 25 humans human NNS cord-333986-xkx181ek 96 26 [ [ -LRB- cord-333986-xkx181ek 96 27 58 58 CD cord-333986-xkx181ek 96 28 ] ] -RRB- cord-333986-xkx181ek 96 29 [ [ -LRB- cord-333986-xkx181ek 96 30 59 59 CD cord-333986-xkx181ek 96 31 ] ] -RRB- cord-333986-xkx181ek 96 32 [ [ -LRB- cord-333986-xkx181ek 96 33 60 60 CD cord-333986-xkx181ek 96 34 ] ] -RRB- cord-333986-xkx181ek 96 35 [ [ -LRB- cord-333986-xkx181ek 96 36 61 61 CD cord-333986-xkx181ek 96 37 ] ] -RRB- cord-333986-xkx181ek 96 38 . . . cord-333986-xkx181ek 97 1 The the DT cord-333986-xkx181ek 97 2 cells cell NNS cord-333986-xkx181ek 97 3 of of IN cord-333986-xkx181ek 97 4 the the DT cord-333986-xkx181ek 97 5 innate innate JJ cord-333986-xkx181ek 97 6 immune immune JJ cord-333986-xkx181ek 97 7 system system NN cord-333986-xkx181ek 97 8 express express VBP cord-333986-xkx181ek 97 9 various various JJ cord-333986-xkx181ek 97 10 pattern pattern NN cord-333986-xkx181ek 97 11 recognition recognition NN cord-333986-xkx181ek 97 12 receptors receptor NNS cord-333986-xkx181ek 97 13 ( ( -LRB- cord-333986-xkx181ek 97 14 PRRs PRRs NNP cord-333986-xkx181ek 97 15 ) ) -RRB- cord-333986-xkx181ek 97 16 that that WDT cord-333986-xkx181ek 97 17 recognize recognize VBP cord-333986-xkx181ek 97 18 specific specific JJ cord-333986-xkx181ek 97 19 pathogen pathogen NN cord-333986-xkx181ek 97 20 - - HYPH cord-333986-xkx181ek 97 21 associated associate VBN cord-333986-xkx181ek 97 22 molecular molecular JJ cord-333986-xkx181ek 97 23 patterns pattern NNS cord-333986-xkx181ek 97 24 ( ( -LRB- cord-333986-xkx181ek 97 25 PAMPs pamp NNS cord-333986-xkx181ek 97 26 ) ) -RRB- cord-333986-xkx181ek 97 27 to to TO cord-333986-xkx181ek 97 28 mount mount VB cord-333986-xkx181ek 97 29 a a DT cord-333986-xkx181ek 97 30 highly highly RB cord-333986-xkx181ek 97 31 coordinated coordinated JJ cord-333986-xkx181ek 97 32 immune immune JJ cord-333986-xkx181ek 97 33 response response NN cord-333986-xkx181ek 97 34 [ [ -LRB- cord-333986-xkx181ek 97 35 62 62 CD cord-333986-xkx181ek 97 36 ] ] -RRB- cord-333986-xkx181ek 97 37 . . . cord-333986-xkx181ek 98 1 Toll toll NN cord-333986-xkx181ek 98 2 - - HYPH cord-333986-xkx181ek 98 3 like like JJ cord-333986-xkx181ek 98 4 Receptors receptor NNS cord-333986-xkx181ek 98 5 ( ( -LRB- cord-333986-xkx181ek 98 6 TLRs TLRs NNP cord-333986-xkx181ek 98 7 ) ) -RRB- cord-333986-xkx181ek 98 8 are be VBP cord-333986-xkx181ek 98 9 a a DT cord-333986-xkx181ek 98 10 type type NN cord-333986-xkx181ek 98 11 of of IN cord-333986-xkx181ek 98 12 PRR PRR NNP cord-333986-xkx181ek 98 13 that that WDT cord-333986-xkx181ek 98 14 can can MD cord-333986-xkx181ek 98 15 be be VB cord-333986-xkx181ek 98 16 found find VBN cord-333986-xkx181ek 98 17 on on IN cord-333986-xkx181ek 98 18 the the DT cord-333986-xkx181ek 98 19 cells cell NNS cord-333986-xkx181ek 98 20 of of IN cord-333986-xkx181ek 98 21 the the DT cord-333986-xkx181ek 98 22 innate innate JJ cord-333986-xkx181ek 98 23 immune immune JJ cord-333986-xkx181ek 98 24 system system NN cord-333986-xkx181ek 98 25 ( ( -LRB- cord-333986-xkx181ek 98 26 monocytes monocyte NNS cord-333986-xkx181ek 98 27 / / SYM cord-333986-xkx181ek 98 28 macrophages macrophage NNS cord-333986-xkx181ek 98 29 , , , cord-333986-xkx181ek 98 30 neutrophils neutrophil NNS cord-333986-xkx181ek 98 31 , , , cord-333986-xkx181ek 98 32 dendritic dendritic JJ cord-333986-xkx181ek 98 33 cells cell NNS cord-333986-xkx181ek 98 34 , , , cord-333986-xkx181ek 98 35 and and CC cord-333986-xkx181ek 98 36 natural natural JJ cord-333986-xkx181ek 98 37 killer killer NN cord-333986-xkx181ek 98 38 cells cell NNS cord-333986-xkx181ek 98 39 ) ) -RRB- cord-333986-xkx181ek 98 40 , , , cord-333986-xkx181ek 98 41 playing play VBG cord-333986-xkx181ek 98 42 a a DT cord-333986-xkx181ek 98 43 significant significant JJ cord-333986-xkx181ek 98 44 role role NN cord-333986-xkx181ek 98 45 in in IN cord-333986-xkx181ek 98 46 the the DT cord-333986-xkx181ek 98 47 induction induction NN cord-333986-xkx181ek 98 48 of of IN cord-333986-xkx181ek 98 49 a a DT cord-333986-xkx181ek 98 50 pro pro JJ cord-333986-xkx181ek 98 51 - - JJ cord-333986-xkx181ek 98 52 inflammatory inflammatory JJ cord-333986-xkx181ek 98 53 immune immune JJ cord-333986-xkx181ek 98 54 response response NN cord-333986-xkx181ek 98 55 [ [ -LRB- cord-333986-xkx181ek 98 56 62 62 CD cord-333986-xkx181ek 98 57 ] ] -RRB- cord-333986-xkx181ek 98 58 . . . cord-333986-xkx181ek 99 1 Interestingly interestingly RB cord-333986-xkx181ek 99 2 , , , cord-333986-xkx181ek 99 3 Flynn Flynn NNP cord-333986-xkx181ek 99 4 et et NNP cord-333986-xkx181ek 99 5 al al NNP cord-333986-xkx181ek 99 6 . . NNP cord-333986-xkx181ek 99 7 , , , cord-333986-xkx181ek 99 8 showed show VBD cord-333986-xkx181ek 99 9 that that IN cord-333986-xkx181ek 99 10 there there EX cord-333986-xkx181ek 99 11 was be VBD cord-333986-xkx181ek 99 12 a a DT cord-333986-xkx181ek 99 13 blunted blunted JJ cord-333986-xkx181ek 99 14 response response NN cord-333986-xkx181ek 99 15 of of IN cord-333986-xkx181ek 99 16 LPS LPS NNP cord-333986-xkx181ek 99 17 - - HYPH cord-333986-xkx181ek 99 18 stimulated stimulate VBN cord-333986-xkx181ek 99 19 blood blood NN cord-333986-xkx181ek 99 20 cultures culture NNS cord-333986-xkx181ek 99 21 collected collect VBN cord-333986-xkx181ek 99 22 from from IN cord-333986-xkx181ek 99 23 older old JJR cord-333986-xkx181ek 99 24 women woman NNS cord-333986-xkx181ek 99 25 following follow VBG cord-333986-xkx181ek 99 26 ten ten CD cord-333986-xkx181ek 99 27 weeks week NNS cord-333986-xkx181ek 99 28 of of IN cord-333986-xkx181ek 99 29 resistive resistive JJ cord-333986-xkx181ek 99 30 exercise exercise NN cord-333986-xkx181ek 99 31 training training NN cord-333986-xkx181ek 99 32 [ [ -LRB- cord-333986-xkx181ek 99 33 63 63 CD cord-333986-xkx181ek 99 34 , , , cord-333986-xkx181ek 99 35 64 64 CD cord-333986-xkx181ek 99 36 ] ] -RRB- cord-333986-xkx181ek 99 37 . . . cord-333986-xkx181ek 100 1 TLR4 TLR4 NNP cord-333986-xkx181ek 100 2 mRNA mrna NN cord-333986-xkx181ek 100 3 was be VBD cord-333986-xkx181ek 100 4 lower low JJR cord-333986-xkx181ek 100 5 in in IN cord-333986-xkx181ek 100 6 the the DT cord-333986-xkx181ek 100 7 women woman NNS cord-333986-xkx181ek 100 8 who who WP cord-333986-xkx181ek 100 9 participated participate VBD cord-333986-xkx181ek 100 10 in in IN cord-333986-xkx181ek 100 11 the the DT cord-333986-xkx181ek 100 12 training training NN cord-333986-xkx181ek 100 13 versus versus IN cord-333986-xkx181ek 100 14 the the DT cord-333986-xkx181ek 100 15 women woman NNS cord-333986-xkx181ek 100 16 who who WP cord-333986-xkx181ek 100 17 did do VBD cord-333986-xkx181ek 100 18 not not RB cord-333986-xkx181ek 100 19 [ [ -LRB- cord-333986-xkx181ek 100 20 63 63 CD cord-333986-xkx181ek 100 21 , , , cord-333986-xkx181ek 100 22 64 64 CD cord-333986-xkx181ek 100 23 ] ] -RRB- cord-333986-xkx181ek 100 24 . . . cord-333986-xkx181ek 101 1 Further further JJ cord-333986-xkx181ek 101 2 studies study NNS cord-333986-xkx181ek 101 3 have have VBP cord-333986-xkx181ek 101 4 been be VBN cord-333986-xkx181ek 101 5 conducted conduct VBN cord-333986-xkx181ek 101 6 in in IN cord-333986-xkx181ek 101 7 elderly elderly JJ cord-333986-xkx181ek 101 8 populations population NNS cord-333986-xkx181ek 101 9 , , , cord-333986-xkx181ek 101 10 showing show VBG cord-333986-xkx181ek 101 11 a a DT cord-333986-xkx181ek 101 12 reduction reduction NN cord-333986-xkx181ek 101 13 in in IN cord-333986-xkx181ek 101 14 both both DT cord-333986-xkx181ek 101 15 TLR2 TLR2 NNP cord-333986-xkx181ek 101 16 and and CC cord-333986-xkx181ek 101 17 TLR4 TLR4 NNP cord-333986-xkx181ek 101 18 protein protein NN cord-333986-xkx181ek 101 19 following follow VBG cord-333986-xkx181ek 101 20 resistance resistance NN cord-333986-xkx181ek 101 21 - - HYPH cord-333986-xkx181ek 101 22 training training NN cord-333986-xkx181ek 101 23 programs program NNS cord-333986-xkx181ek 101 24 . . . cord-333986-xkx181ek 102 1 Collectively collectively RB cord-333986-xkx181ek 102 2 , , , cord-333986-xkx181ek 102 3 these these DT cord-333986-xkx181ek 102 4 findings finding NNS cord-333986-xkx181ek 102 5 provide provide VBP cord-333986-xkx181ek 102 6 additional additional JJ cord-333986-xkx181ek 102 7 evidence evidence NN cord-333986-xkx181ek 102 8 for for IN cord-333986-xkx181ek 102 9 an an DT cord-333986-xkx181ek 102 10 exercise exercise NN cord-333986-xkx181ek 102 11 - - HYPH cord-333986-xkx181ek 102 12 induced induce VBN cord-333986-xkx181ek 102 13 anti anti JJ cord-333986-xkx181ek 102 14 - - JJ cord-333986-xkx181ek 102 15 inflammatory inflammatory JJ cord-333986-xkx181ek 102 16 status status NN cord-333986-xkx181ek 102 17 . . . cord-333986-xkx181ek 103 1 As as IN cord-333986-xkx181ek 103 2 mentioned mention VBN cord-333986-xkx181ek 103 3 in in IN cord-333986-xkx181ek 103 4 Figure figure NN cord-333986-xkx181ek 103 5 1 1 CD cord-333986-xkx181ek 103 6 , , , cord-333986-xkx181ek 103 7 exercise exercise NN cord-333986-xkx181ek 103 8 promotes promote VBZ cord-333986-xkx181ek 103 9 some some DT cord-333986-xkx181ek 103 10 wide wide RB cord-333986-xkx181ek 103 11 - - HYPH cord-333986-xkx181ek 103 12 ranging range VBG cord-333986-xkx181ek 103 13 changes change NNS cord-333986-xkx181ek 103 14 in in IN cord-333986-xkx181ek 103 15 both both DT cord-333986-xkx181ek 103 16 innate innate JJ cord-333986-xkx181ek 103 17 and and CC cord-333986-xkx181ek 103 18 adaptive adaptive JJ cord-333986-xkx181ek 103 19 cells cell NNS cord-333986-xkx181ek 103 20 , , , cord-333986-xkx181ek 103 21 including include VBG cord-333986-xkx181ek 103 22 increased increase VBN cord-333986-xkx181ek 103 23 phagocytic phagocytic JJ cord-333986-xkx181ek 103 24 cell cell NN cord-333986-xkx181ek 103 25 action action NN cord-333986-xkx181ek 103 26 , , , cord-333986-xkx181ek 103 27 increased increase VBD cord-333986-xkx181ek 103 28 T t NN cord-333986-xkx181ek 103 29 cell cell NN cord-333986-xkx181ek 103 30 proliferation proliferation NN cord-333986-xkx181ek 103 31 , , , cord-333986-xkx181ek 103 32 and and CC cord-333986-xkx181ek 103 33 redistribution redistribution NN cord-333986-xkx181ek 103 34 of of IN cord-333986-xkx181ek 103 35 lymphocytes lymphocyte NNS cord-333986-xkx181ek 103 36 to to TO cord-333986-xkx181ek 103 37 further further RB cord-333986-xkx181ek 103 38 strengthen strengthen VB cord-333986-xkx181ek 103 39 the the DT cord-333986-xkx181ek 103 40 defense defense NN cord-333986-xkx181ek 103 41 system system NN cord-333986-xkx181ek 103 42 [ [ -LRB- cord-333986-xkx181ek 103 43 27 27 CD cord-333986-xkx181ek 103 44 ] ] -RRB- cord-333986-xkx181ek 103 45 . . . cord-333986-xkx181ek 104 1 Lowder Lowder NNP cord-333986-xkx181ek 104 2 et et NNP cord-333986-xkx181ek 104 3 al al NNP cord-333986-xkx181ek 104 4 . . . cord-333986-xkx181ek 104 5 investigated investigate VBD cord-333986-xkx181ek 104 6 the the DT cord-333986-xkx181ek 104 7 immunologic immunologic JJ cord-333986-xkx181ek 104 8 mechanism mechanism NN cord-333986-xkx181ek 104 9 as as IN cord-333986-xkx181ek 104 10 to to IN cord-333986-xkx181ek 104 11 why why WRB cord-333986-xkx181ek 104 12 moderate moderate JJ cord-333986-xkx181ek 104 13 - - HYPH cord-333986-xkx181ek 104 14 intensity intensity NN cord-333986-xkx181ek 104 15 exercise exercise NN cord-333986-xkx181ek 104 16 produces produce VBZ cord-333986-xkx181ek 104 17 the the DT cord-333986-xkx181ek 104 18 most most RBS cord-333986-xkx181ek 104 19 beneficial beneficial JJ cord-333986-xkx181ek 104 20 health health NN cord-333986-xkx181ek 104 21 response response NN cord-333986-xkx181ek 104 22 [ [ -LRB- cord-333986-xkx181ek 104 23 53 53 CD cord-333986-xkx181ek 104 24 ] ] -RRB- cord-333986-xkx181ek 104 25 . . . cord-333986-xkx181ek 105 1 In in IN cord-333986-xkx181ek 105 2 the the DT cord-333986-xkx181ek 105 3 study study NN cord-333986-xkx181ek 105 4 , , , cord-333986-xkx181ek 105 5 mice mouse NNS cord-333986-xkx181ek 105 6 that that WDT cord-333986-xkx181ek 105 7 performed perform VBD cord-333986-xkx181ek 105 8 20 20 CD cord-333986-xkx181ek 105 9 - - SYM cord-333986-xkx181ek 105 10 30 30 CD cord-333986-xkx181ek 105 11 min min NN cord-333986-xkx181ek 105 12 of of IN cord-333986-xkx181ek 105 13 moderate moderate JJ cord-333986-xkx181ek 105 14 - - HYPH cord-333986-xkx181ek 105 15 intensity intensity NN cord-333986-xkx181ek 105 16 treadmill treadmill NN cord-333986-xkx181ek 105 17 exercise exercise NN cord-333986-xkx181ek 105 18 had have VBD cord-333986-xkx181ek 105 19 significantly significantly RB cord-333986-xkx181ek 105 20 reduced reduce VBN cord-333986-xkx181ek 105 21 total total JJ cord-333986-xkx181ek 105 22 cellular cellular JJ cord-333986-xkx181ek 105 23 infiltration infiltration NN cord-333986-xkx181ek 105 24 and and CC cord-333986-xkx181ek 105 25 IFN IFN NNP cord-333986-xkx181ek 105 26 - - HYPH cord-333986-xkx181ek 105 27 γ γ NN cord-333986-xkx181ek 105 28 gene gene NN cord-333986-xkx181ek 105 29 expression expression NN cord-333986-xkx181ek 105 30 in in IN cord-333986-xkx181ek 105 31 lung lung NN cord-333986-xkx181ek 105 32 tissue tissue NN cord-333986-xkx181ek 105 33 compared compare VBN cord-333986-xkx181ek 105 34 to to IN cord-333986-xkx181ek 105 35 the the DT cord-333986-xkx181ek 105 36 sedentary sedentary JJ cord-333986-xkx181ek 105 37 group group NN cord-333986-xkx181ek 105 38 of of IN cord-333986-xkx181ek 105 39 animals animal NNS cord-333986-xkx181ek 105 40 . . . cord-333986-xkx181ek 106 1 The the DT cord-333986-xkx181ek 106 2 exercise exercise NN cord-333986-xkx181ek 106 3 group group NN cord-333986-xkx181ek 106 4 of of IN cord-333986-xkx181ek 106 5 mice mouse NNS cord-333986-xkx181ek 106 6 also also RB cord-333986-xkx181ek 106 7 had have VBD cord-333986-xkx181ek 106 8 a a DT cord-333986-xkx181ek 106 9 shift shift NN cord-333986-xkx181ek 106 10 in in IN cord-333986-xkx181ek 106 11 cytokine cytokine NN cord-333986-xkx181ek 106 12 profile profile NN cord-333986-xkx181ek 106 13 within within IN cord-333986-xkx181ek 106 14 the the DT cord-333986-xkx181ek 106 15 lungs lung NNS cord-333986-xkx181ek 106 16 , , , cord-333986-xkx181ek 106 17 predominately predominately RB cord-333986-xkx181ek 106 18 favoring favor VBG cord-333986-xkx181ek 106 19 T T NNP cord-333986-xkx181ek 106 20 H h NN cord-333986-xkx181ek 106 21 2 2 CD cord-333986-xkx181ek 106 22 cells cell NNS cord-333986-xkx181ek 107 1 > > XX cord-333986-xkx181ek 108 1 T T NNP cord-333986-xkx181ek 108 2 H h NN cord-333986-xkx181ek 108 3 1 1 CD cord-333986-xkx181ek 108 4 cells cell NNS cord-333986-xkx181ek 108 5 in in IN cord-333986-xkx181ek 108 6 comparison comparison NN cord-333986-xkx181ek 108 7 to to IN cord-333986-xkx181ek 108 8 sedentary sedentary JJ cord-333986-xkx181ek 108 9 controls control NNS cord-333986-xkx181ek 108 10 . . . cord-333986-xkx181ek 109 1 In in IN cord-333986-xkx181ek 109 2 support support NN cord-333986-xkx181ek 109 3 of of IN cord-333986-xkx181ek 109 4 this this DT cord-333986-xkx181ek 109 5 finding finding NN cord-333986-xkx181ek 109 6 , , , cord-333986-xkx181ek 109 7 there there EX cord-333986-xkx181ek 109 8 was be VBD cord-333986-xkx181ek 109 9 a a DT cord-333986-xkx181ek 109 10 two two CD cord-333986-xkx181ek 109 11 - - HYPH cord-333986-xkx181ek 109 12 fold fold JJ cord-333986-xkx181ek 109 13 increase increase NN cord-333986-xkx181ek 109 14 in in IN cord-333986-xkx181ek 109 15 IL-4 IL-4 NNP cord-333986-xkx181ek 109 16 within within IN cord-333986-xkx181ek 109 17 exercise exercise NN cord-333986-xkx181ek 109 18 mice mouse NNS cord-333986-xkx181ek 109 19 , , , cord-333986-xkx181ek 109 20 a a DT cord-333986-xkx181ek 109 21 cytokine cytokine NN cord-333986-xkx181ek 109 22 that that WDT cord-333986-xkx181ek 109 23 promotes promote VBZ cord-333986-xkx181ek 109 24 differentiation differentiation NN cord-333986-xkx181ek 109 25 of of IN cord-333986-xkx181ek 109 26 naïve naïve JJ cord-333986-xkx181ek 109 27 T t NN cord-333986-xkx181ek 109 28 H h NN cord-333986-xkx181ek 109 29 cells cell NNS cord-333986-xkx181ek 109 30 to to IN cord-333986-xkx181ek 109 31 T t NN cord-333986-xkx181ek 109 32 H h NN cord-333986-xkx181ek 109 33 2 2 CD cord-333986-xkx181ek 109 34 [ [ -LRB- cord-333986-xkx181ek 109 35 53 53 CD cord-333986-xkx181ek 109 36 ] ] -RRB- cord-333986-xkx181ek 109 37 . . . cord-333986-xkx181ek 110 1 Although although IN cord-333986-xkx181ek 110 2 these these DT cord-333986-xkx181ek 110 3 results result NNS cord-333986-xkx181ek 110 4 show show VBP cord-333986-xkx181ek 110 5 a a DT cord-333986-xkx181ek 110 6 slight slight JJ cord-333986-xkx181ek 110 7 preference preference NN cord-333986-xkx181ek 110 8 for for IN cord-333986-xkx181ek 110 9 anti anti JJ cord-333986-xkx181ek 110 10 - - JJ cord-333986-xkx181ek 110 11 inflammatory inflammatory JJ cord-333986-xkx181ek 110 12 T t NN cord-333986-xkx181ek 110 13 H h NN cord-333986-xkx181ek 110 14 2 2 CD cord-333986-xkx181ek 110 15 cells cell NNS cord-333986-xkx181ek 110 16 in in IN cord-333986-xkx181ek 110 17 the the DT cord-333986-xkx181ek 110 18 lungs lung NNS cord-333986-xkx181ek 110 19 , , , cord-333986-xkx181ek 110 20 the the DT cord-333986-xkx181ek 110 21 T T NNP cord-333986-xkx181ek 110 22 H h NN cord-333986-xkx181ek 110 23 1 1 CD cord-333986-xkx181ek 110 24 cellular cellular JJ cord-333986-xkx181ek 110 25 response response NN cord-333986-xkx181ek 110 26 is be VBZ cord-333986-xkx181ek 110 27 diminished diminish VBN cord-333986-xkx181ek 110 28 but but CC cord-333986-xkx181ek 110 29 still still RB cord-333986-xkx181ek 110 30 able able JJ cord-333986-xkx181ek 110 31 to to TO cord-333986-xkx181ek 110 32 perform perform VB cord-333986-xkx181ek 110 33 immunosurveillance immunosurveillance NN cord-333986-xkx181ek 110 34 . . . cord-333986-xkx181ek 111 1 The the DT cord-333986-xkx181ek 111 2 T t NN cord-333986-xkx181ek 111 3 H h NN cord-333986-xkx181ek 111 4 2 2 CD cord-333986-xkx181ek 111 5 skewing skewing NN cord-333986-xkx181ek 111 6 that that WDT cord-333986-xkx181ek 111 7 initiates initiate VBZ cord-333986-xkx181ek 111 8 the the DT cord-333986-xkx181ek 111 9 adaptive adaptive JJ cord-333986-xkx181ek 111 10 immune immune JJ cord-333986-xkx181ek 111 11 response response NN cord-333986-xkx181ek 111 12 and and CC cord-333986-xkx181ek 111 13 anti anti JJ cord-333986-xkx181ek 111 14 - - JJ cord-333986-xkx181ek 111 15 inflammatory inflammatory JJ cord-333986-xkx181ek 111 16 modulators modulator NNS cord-333986-xkx181ek 111 17 , , , cord-333986-xkx181ek 111 18 though though RB cord-333986-xkx181ek 111 19 , , , cord-333986-xkx181ek 111 20 balances balance VBZ cord-333986-xkx181ek 111 21 this this DT cord-333986-xkx181ek 111 22 pro pro JJ cord-333986-xkx181ek 111 23 - - JJ cord-333986-xkx181ek 111 24 inflammatory inflammatory JJ cord-333986-xkx181ek 111 25 reaction reaction NN cord-333986-xkx181ek 111 26 . . . cord-333986-xkx181ek 112 1 In in IN cord-333986-xkx181ek 112 2 comparison comparison NN cord-333986-xkx181ek 112 3 , , , cord-333986-xkx181ek 112 4 there there EX cord-333986-xkx181ek 112 5 is be VBZ cord-333986-xkx181ek 112 6 a a DT cord-333986-xkx181ek 112 7 highly highly RB cord-333986-xkx181ek 112 8 polarized polarized JJ cord-333986-xkx181ek 112 9 T t NN cord-333986-xkx181ek 112 10 H h NN cord-333986-xkx181ek 112 11 2 2 CD cord-333986-xkx181ek 112 12 to to IN cord-333986-xkx181ek 112 13 T T NNP cord-333986-xkx181ek 112 14 H h NN cord-333986-xkx181ek 112 15 1 1 CD cord-333986-xkx181ek 112 16 profile profile NN cord-333986-xkx181ek 112 17 shift shift NN cord-333986-xkx181ek 112 18 during during IN cord-333986-xkx181ek 112 19 high high JJ cord-333986-xkx181ek 112 20 - - HYPH cord-333986-xkx181ek 112 21 intensity intensity NN cord-333986-xkx181ek 112 22 , , , cord-333986-xkx181ek 112 23 prolonged prolong VBN cord-333986-xkx181ek 112 24 exercise exercise NN cord-333986-xkx181ek 112 25 , , , cord-333986-xkx181ek 112 26 representing represent VBG cord-333986-xkx181ek 112 27 a a DT cord-333986-xkx181ek 112 28 severe severe JJ cord-333986-xkx181ek 112 29 reduction reduction NN cord-333986-xkx181ek 112 30 in in IN cord-333986-xkx181ek 112 31 a a DT cord-333986-xkx181ek 112 32 pro pro JJ cord-333986-xkx181ek 112 33 - - JJ cord-333986-xkx181ek 112 34 inflammatory inflammatory JJ cord-333986-xkx181ek 112 35 response response NN cord-333986-xkx181ek 112 36 and and CC cord-333986-xkx181ek 112 37 a a DT cord-333986-xkx181ek 112 38 large large JJ cord-333986-xkx181ek 112 39 increase increase NN cord-333986-xkx181ek 112 40 in in IN cord-333986-xkx181ek 112 41 an an DT cord-333986-xkx181ek 112 42 anti anti JJ cord-333986-xkx181ek 112 43 - - JJ cord-333986-xkx181ek 112 44 inflammatory inflammatory JJ cord-333986-xkx181ek 112 45 one one CD cord-333986-xkx181ek 112 46 . . . cord-333986-xkx181ek 113 1 Martin Martin NNP cord-333986-xkx181ek 113 2 et et NNP cord-333986-xkx181ek 113 3 al al NNP cord-333986-xkx181ek 113 4 . . . cord-333986-xkx181ek 114 1 also also RB cord-333986-xkx181ek 114 2 found find VBD cord-333986-xkx181ek 114 3 that that IN cord-333986-xkx181ek 114 4 moderate moderate JJ cord-333986-xkx181ek 114 5 - - HYPH cord-333986-xkx181ek 114 6 intensity intensity NN cord-333986-xkx181ek 114 7 exercise exercise NN cord-333986-xkx181ek 114 8 shifts shift NNS cord-333986-xkx181ek 114 9 both both CC cord-333986-xkx181ek 114 10 innate innate JJ cord-333986-xkx181ek 114 11 and and CC cord-333986-xkx181ek 114 12 adaptive adaptive JJ cord-333986-xkx181ek 114 13 immune immune JJ cord-333986-xkx181ek 114 14 systems system NNS cord-333986-xkx181ek 114 15 in in IN cord-333986-xkx181ek 114 16 slight slight JJ cord-333986-xkx181ek 114 17 favor favor NN cord-333986-xkx181ek 114 18 of of IN cord-333986-xkx181ek 114 19 T T NNP cord-333986-xkx181ek 114 20 H h NN cord-333986-xkx181ek 114 21 2 2 CD cord-333986-xkx181ek 114 22 cells cell NNS cord-333986-xkx181ek 114 23 , , , cord-333986-xkx181ek 114 24 providing provide VBG cord-333986-xkx181ek 114 25 a a DT cord-333986-xkx181ek 114 26 more more RBR cord-333986-xkx181ek 114 27 favorable favorable JJ cord-333986-xkx181ek 114 28 reduction reduction NN cord-333986-xkx181ek 114 29 in in IN cord-333986-xkx181ek 114 30 T T NNP cord-333986-xkx181ek 114 31 H h NN cord-333986-xkx181ek 114 32 1 1 CD cord-333986-xkx181ek 114 33 cell cell NN cord-333986-xkx181ek 114 34 response response NN cord-333986-xkx181ek 114 35 to to IN cord-333986-xkx181ek 114 36 viral viral JJ cord-333986-xkx181ek 114 37 pathogens pathogen NNS cord-333986-xkx181ek 114 38 in in IN cord-333986-xkx181ek 114 39 comparison comparison NN cord-333986-xkx181ek 114 40 to to IN cord-333986-xkx181ek 114 41 high high JJ cord-333986-xkx181ek 114 42 - - HYPH cord-333986-xkx181ek 114 43 intensity intensity NN cord-333986-xkx181ek 114 44 exercise exercise NN cord-333986-xkx181ek 114 45 [ [ -LRB- cord-333986-xkx181ek 114 46 28 28 CD cord-333986-xkx181ek 114 47 ] ] -RRB- cord-333986-xkx181ek 114 48 . . . cord-333986-xkx181ek 115 1 Furthermore furthermore RB cord-333986-xkx181ek 115 2 , , , cord-333986-xkx181ek 115 3 there there EX cord-333986-xkx181ek 115 4 is be VBZ cord-333986-xkx181ek 115 5 a a DT cord-333986-xkx181ek 115 6 substantial substantial JJ cord-333986-xkx181ek 115 7 increase increase NN cord-333986-xkx181ek 115 8 in in IN cord-333986-xkx181ek 115 9 oxidative oxidative JJ cord-333986-xkx181ek 115 10 stress stress NN cord-333986-xkx181ek 115 11 under under IN cord-333986-xkx181ek 115 12 prolonged prolong VBN cord-333986-xkx181ek 115 13 high high JJ cord-333986-xkx181ek 115 14 - - HYPH cord-333986-xkx181ek 115 15 intensity intensity NN cord-333986-xkx181ek 115 16 exercise exercise NN cord-333986-xkx181ek 115 17 conditions condition NNS cord-333986-xkx181ek 115 18 [ [ -LRB- cord-333986-xkx181ek 115 19 65 65 CD cord-333986-xkx181ek 115 20 ] ] -RRB- cord-333986-xkx181ek 115 21 , , , cord-333986-xkx181ek 115 22 and and CC cord-333986-xkx181ek 115 23 the the DT cord-333986-xkx181ek 115 24 concentration concentration NN cord-333986-xkx181ek 115 25 of of IN cord-333986-xkx181ek 115 26 salivary salivary NNP cord-333986-xkx181ek 115 27 IgA IgA NNP cord-333986-xkx181ek 115 28 , , , cord-333986-xkx181ek 115 29 which which WDT cord-333986-xkx181ek 115 30 serves serve VBZ cord-333986-xkx181ek 115 31 to to TO cord-333986-xkx181ek 115 32 inactivate inactivate VB cord-333986-xkx181ek 115 33 foreign foreign JJ cord-333986-xkx181ek 115 34 substances substance NNS cord-333986-xkx181ek 115 35 , , , cord-333986-xkx181ek 115 36 is be VBZ cord-333986-xkx181ek 115 37 reduced reduce VBN cord-333986-xkx181ek 115 38 in in IN cord-333986-xkx181ek 115 39 subjects subject NNS cord-333986-xkx181ek 115 40 of of IN cord-333986-xkx181ek 115 41 prolonged prolonged JJ cord-333986-xkx181ek 115 42 high high JJ cord-333986-xkx181ek 115 43 - - HYPH cord-333986-xkx181ek 115 44 intensity intensity NN cord-333986-xkx181ek 115 45 exercise exercise NN cord-333986-xkx181ek 115 46 duration duration NN cord-333986-xkx181ek 115 47 [ [ -LRB- cord-333986-xkx181ek 115 48 66 66 CD cord-333986-xkx181ek 115 49 ] ] -RRB- cord-333986-xkx181ek 115 50 . . . cord-333986-xkx181ek 116 1 In in IN cord-333986-xkx181ek 116 2 summary summary NN cord-333986-xkx181ek 116 3 , , , cord-333986-xkx181ek 116 4 when when WRB cord-333986-xkx181ek 116 5 exposing expose VBG cord-333986-xkx181ek 116 6 the the DT cord-333986-xkx181ek 116 7 body body NN cord-333986-xkx181ek 116 8 to to IN cord-333986-xkx181ek 116 9 moderate moderate JJ cord-333986-xkx181ek 116 10 - - HYPH cord-333986-xkx181ek 116 11 intensity intensity NN cord-333986-xkx181ek 116 12 exercise exercise NN cord-333986-xkx181ek 116 13 training training NN cord-333986-xkx181ek 116 14 , , , cord-333986-xkx181ek 116 15 there there EX cord-333986-xkx181ek 116 16 is be VBZ cord-333986-xkx181ek 116 17 the the DT cord-333986-xkx181ek 116 18 best good JJS cord-333986-xkx181ek 116 19 balance balance NN cord-333986-xkx181ek 116 20 between between IN cord-333986-xkx181ek 116 21 the the DT cord-333986-xkx181ek 116 22 pro pro JJ cord-333986-xkx181ek 116 23 - - JJ cord-333986-xkx181ek 116 24 and and CC cord-333986-xkx181ek 116 25 anti anti JJ cord-333986-xkx181ek 116 26 - - JJ cord-333986-xkx181ek 116 27 inflammatory inflammatory JJ cord-333986-xkx181ek 116 28 immune immune JJ cord-333986-xkx181ek 116 29 benefits benefit NNS cord-333986-xkx181ek 116 30 : : : cord-333986-xkx181ek 116 31 an an DT cord-333986-xkx181ek 116 32 initial initial JJ cord-333986-xkx181ek 116 33 increase increase NN cord-333986-xkx181ek 116 34 in in IN cord-333986-xkx181ek 116 35 immunosurveillance immunosurveillance NN cord-333986-xkx181ek 116 36 and and CC cord-333986-xkx181ek 116 37 an an DT cord-333986-xkx181ek 116 38 overall overall JJ cord-333986-xkx181ek 116 39 reduction reduction NN cord-333986-xkx181ek 116 40 in in IN cord-333986-xkx181ek 116 41 excessive excessive JJ cord-333986-xkx181ek 116 42 local local JJ cord-333986-xkx181ek 116 43 pro pro JJ cord-333986-xkx181ek 116 44 - - JJ cord-333986-xkx181ek 116 45 inflammatory inflammatory JJ cord-333986-xkx181ek 116 46 markers marker NNS cord-333986-xkx181ek 116 47 ( ( -LRB- cord-333986-xkx181ek 116 48 Figure figure NN cord-333986-xkx181ek 116 49 3 3 CD cord-333986-xkx181ek 116 50 ) ) -RRB- cord-333986-xkx181ek 116 51 . . . cord-333986-xkx181ek 117 1 Aspects aspect NNS cord-333986-xkx181ek 117 2 of of IN cord-333986-xkx181ek 117 3 both both CC cord-333986-xkx181ek 117 4 the the DT cord-333986-xkx181ek 117 5 innate innate JJ cord-333986-xkx181ek 117 6 and and CC cord-333986-xkx181ek 117 7 adaptive adaptive JJ cord-333986-xkx181ek 117 8 immune immune JJ cord-333986-xkx181ek 117 9 systems system NNS cord-333986-xkx181ek 117 10 are be VBP cord-333986-xkx181ek 117 11 active active JJ cord-333986-xkx181ek 117 12 in in IN cord-333986-xkx181ek 117 13 PD PD NNP cord-333986-xkx181ek 117 14 , , , cord-333986-xkx181ek 117 15 and and CC cord-333986-xkx181ek 117 16 they -PRON- PRP cord-333986-xkx181ek 117 17 contribute contribute VBP cord-333986-xkx181ek 117 18 to to IN cord-333986-xkx181ek 117 19 the the DT cord-333986-xkx181ek 117 20 pathogenesis pathogenesis NN cord-333986-xkx181ek 117 21 of of IN cord-333986-xkx181ek 117 22 the the DT cord-333986-xkx181ek 117 23 disorder disorder NN cord-333986-xkx181ek 117 24 [ [ -LRB- cord-333986-xkx181ek 117 25 67 67 CD cord-333986-xkx181ek 117 26 , , , cord-333986-xkx181ek 117 27 68 68 CD cord-333986-xkx181ek 117 28 ] ] -RRB- cord-333986-xkx181ek 117 29 . . . cord-333986-xkx181ek 118 1 In in IN cord-333986-xkx181ek 118 2 the the DT cord-333986-xkx181ek 118 3 periphery periphery NN cord-333986-xkx181ek 118 4 , , , cord-333986-xkx181ek 118 5 circulating circulate VBG cord-333986-xkx181ek 118 6 monocytes monocyte NNS cord-333986-xkx181ek 118 7 , , , cord-333986-xkx181ek 118 8 tissue tissue NN cord-333986-xkx181ek 118 9 macrophages macrophage NNS cord-333986-xkx181ek 118 10 , , , cord-333986-xkx181ek 118 11 and and CC cord-333986-xkx181ek 118 12 dendrites dendrite NNS cord-333986-xkx181ek 118 13 have have VBP cord-333986-xkx181ek 118 14 an an DT cord-333986-xkx181ek 118 15 essential essential JJ cord-333986-xkx181ek 118 16 role role NN cord-333986-xkx181ek 118 17 in in IN cord-333986-xkx181ek 118 18 maintaining maintain VBG cord-333986-xkx181ek 118 19 the the DT cord-333986-xkx181ek 118 20 body body NN cord-333986-xkx181ek 118 21 's 's POS cord-333986-xkx181ek 118 22 cellular cellular JJ cord-333986-xkx181ek 118 23 environment environment NN cord-333986-xkx181ek 118 24 through through IN cord-333986-xkx181ek 118 25 phagocytosis phagocytosis NN cord-333986-xkx181ek 118 26 , , , cord-333986-xkx181ek 118 27 antigen antigen NN cord-333986-xkx181ek 118 28 processing processing NN cord-333986-xkx181ek 118 29 and and CC cord-333986-xkx181ek 118 30 presentation presentation NN cord-333986-xkx181ek 118 31 , , , cord-333986-xkx181ek 118 32 and and CC cord-333986-xkx181ek 118 33 the the DT cord-333986-xkx181ek 118 34 production production NN cord-333986-xkx181ek 118 35 of of IN cord-333986-xkx181ek 118 36 cytokines cytokine NNS cord-333986-xkx181ek 118 37 and and CC cord-333986-xkx181ek 118 38 chemokines chemokine NNS cord-333986-xkx181ek 118 39 [ [ -LRB- cord-333986-xkx181ek 118 40 47 47 CD cord-333986-xkx181ek 118 41 ] ] -RRB- cord-333986-xkx181ek 118 42 . . . cord-333986-xkx181ek 119 1 The the DT cord-333986-xkx181ek 119 2 CNS CNS NNP cord-333986-xkx181ek 119 3 monocyte monocyte NN cord-333986-xkx181ek 119 4 equivalent equivalent NN cord-333986-xkx181ek 119 5 is be VBZ cord-333986-xkx181ek 119 6 the the DT cord-333986-xkx181ek 119 7 microglia microglia JJ cord-333986-xkx181ek 119 8 cell cell NN cord-333986-xkx181ek 119 9 , , , cord-333986-xkx181ek 119 10 the the DT cord-333986-xkx181ek 119 11 resident resident JJ cord-333986-xkx181ek 119 12 innate innate JJ cord-333986-xkx181ek 119 13 immune immune JJ cord-333986-xkx181ek 119 14 cells cell NNS cord-333986-xkx181ek 119 15 of of IN cord-333986-xkx181ek 119 16 the the DT cord-333986-xkx181ek 119 17 brain brain NN cord-333986-xkx181ek 119 18 [ [ -LRB- cord-333986-xkx181ek 119 19 67 67 CD cord-333986-xkx181ek 119 20 ] ] -RRB- cord-333986-xkx181ek 119 21 . . . cord-333986-xkx181ek 120 1 There there EX cord-333986-xkx181ek 120 2 are be VBP cord-333986-xkx181ek 120 3 two two CD cord-333986-xkx181ek 120 4 subsets subset NNS cord-333986-xkx181ek 120 5 of of IN cord-333986-xkx181ek 120 6 microglia microglia JJ cord-333986-xkx181ek 120 7 cells cell NNS cord-333986-xkx181ek 120 8 : : : cord-333986-xkx181ek 120 9 the the DT cord-333986-xkx181ek 120 10 M1 M1 NNP cord-333986-xkx181ek 120 11 pro pro JJ cord-333986-xkx181ek 120 12 - - JJ cord-333986-xkx181ek 120 13 inflammatory inflammatory JJ cord-333986-xkx181ek 120 14 phenotype phenotype NN cord-333986-xkx181ek 120 15 and and CC cord-333986-xkx181ek 120 16 the the DT cord-333986-xkx181ek 120 17 M2 m2 JJ cord-333986-xkx181ek 120 18 anti anti JJ cord-333986-xkx181ek 120 19 - - JJ cord-333986-xkx181ek 120 20 inflammatory inflammatory JJ cord-333986-xkx181ek 120 21 phenotype phenotype NN cord-333986-xkx181ek 120 22 . . . cord-333986-xkx181ek 121 1 Emerging emerge VBG cord-333986-xkx181ek 121 2 research research NN cord-333986-xkx181ek 121 3 has have VBZ cord-333986-xkx181ek 121 4 begun begin VBN cord-333986-xkx181ek 121 5 exploring explore VBG cord-333986-xkx181ek 121 6 the the DT cord-333986-xkx181ek 121 7 role role NN cord-333986-xkx181ek 121 8 of of IN cord-333986-xkx181ek 121 9 neuroinflammation neuroinflammation NN cord-333986-xkx181ek 121 10 in in IN cord-333986-xkx181ek 121 11 the the DT cord-333986-xkx181ek 121 12 maintenance maintenance NN cord-333986-xkx181ek 121 13 and and CC cord-333986-xkx181ek 121 14 progression progression NN cord-333986-xkx181ek 121 15 of of IN cord-333986-xkx181ek 121 16 PD PD NNP cord-333986-xkx181ek 121 17 ( ( -LRB- cord-333986-xkx181ek 121 18 Figure figure NN cord-333986-xkx181ek 121 19 4 4 CD cord-333986-xkx181ek 121 20 ) ) -RRB- cord-333986-xkx181ek 121 21 [ [ -LRB- cord-333986-xkx181ek 121 22 67 67 CD cord-333986-xkx181ek 121 23 , , , cord-333986-xkx181ek 121 24 68 68 CD cord-333986-xkx181ek 121 25 ] ] -RRB- cord-333986-xkx181ek 121 26 . . . cord-333986-xkx181ek 122 1 There there EX cord-333986-xkx181ek 122 2 is be VBZ cord-333986-xkx181ek 122 3 evidence evidence NN cord-333986-xkx181ek 122 4 of of IN cord-333986-xkx181ek 122 5 sustained sustained JJ cord-333986-xkx181ek 122 6 pro pro JJ cord-333986-xkx181ek 122 7 - - JJ cord-333986-xkx181ek 122 8 inflammatory inflammatory JJ cord-333986-xkx181ek 122 9 microglia microglia JJ cord-333986-xkx181ek 122 10 cell cell NN cord-333986-xkx181ek 122 11 activation activation NN cord-333986-xkx181ek 122 12 and and CC cord-333986-xkx181ek 122 13 T t NN cord-333986-xkx181ek 122 14 cell cell NN cord-333986-xkx181ek 122 15 infiltration infiltration NN cord-333986-xkx181ek 122 16 , , , cord-333986-xkx181ek 122 17 and and CC cord-333986-xkx181ek 122 18 higher high JJR cord-333986-xkx181ek 122 19 levels level NNS cord-333986-xkx181ek 122 20 of of IN cord-333986-xkx181ek 122 21 pro pro JJ cord-333986-xkx181ek 122 22 - - JJ cord-333986-xkx181ek 122 23 inflammatory inflammatory JJ cord-333986-xkx181ek 122 24 cytokines cytokine NNS cord-333986-xkx181ek 122 25 ( ( -LRB- cord-333986-xkx181ek 122 26 TNF TNF NNP cord-333986-xkx181ek 122 27 - - HYPH cord-333986-xkx181ek 122 28 α α NNP cord-333986-xkx181ek 122 29 , , , cord-333986-xkx181ek 122 30 IL-1β il-1β NN cord-333986-xkx181ek 122 31 , , , cord-333986-xkx181ek 122 32 interferon interferon NN cord-333986-xkx181ek 122 33 - - HYPH cord-333986-xkx181ek 122 34 γ γ NN cord-333986-xkx181ek 122 35 , , , cord-333986-xkx181ek 122 36 IL-6 IL-6 NNP cord-333986-xkx181ek 122 37 , , , cord-333986-xkx181ek 122 38 nitric nitric JJ cord-333986-xkx181ek 122 39 oxide oxide NN cord-333986-xkx181ek 122 40 synthase synthase NN cord-333986-xkx181ek 122 41 ) ) -RRB- cord-333986-xkx181ek 122 42 in in IN cord-333986-xkx181ek 122 43 both both DT cord-333986-xkx181ek 122 44 human human JJ cord-333986-xkx181ek 122 45 PD PD NNP cord-333986-xkx181ek 122 46 patients patient NNS cord-333986-xkx181ek 122 47 and and CC cord-333986-xkx181ek 122 48 animal animal NN cord-333986-xkx181ek 122 49 models model NNS cord-333986-xkx181ek 122 50 of of IN cord-333986-xkx181ek 122 51 PD PD NNP cord-333986-xkx181ek 122 52 ( ( -LRB- cord-333986-xkx181ek 122 53 Figure Figure NNP cord-333986-xkx181ek 122 54 4 4 CD cord-333986-xkx181ek 122 55 ) ) -RRB- cord-333986-xkx181ek 122 56 . . . cord-333986-xkx181ek 123 1 As as IN cord-333986-xkx181ek 123 2 PD PD NNP cord-333986-xkx181ek 123 3 progresses progress VBZ cord-333986-xkx181ek 123 4 , , , cord-333986-xkx181ek 123 5 α α NN cord-333986-xkx181ek 123 6 - - HYPH cord-333986-xkx181ek 123 7 synuclein synuclein NNP cord-333986-xkx181ek 123 8 ( ( -LRB- cord-333986-xkx181ek 123 9 α α NNP cord-333986-xkx181ek 123 10 - - HYPH cord-333986-xkx181ek 123 11 Syn Syn NNP cord-333986-xkx181ek 123 12 ) ) -RRB- cord-333986-xkx181ek 123 13 , , , cord-333986-xkx181ek 123 14 ATP ATP NNP cord-333986-xkx181ek 123 15 , , , cord-333986-xkx181ek 123 16 and and CC cord-333986-xkx181ek 123 17 metalloproteinase-3 metalloproteinase-3 NNP cord-333986-xkx181ek 123 18 are be VBP cord-333986-xkx181ek 123 19 released release VBN cord-333986-xkx181ek 123 20 from from IN cord-333986-xkx181ek 123 21 degenerating degenerate VBG cord-333986-xkx181ek 123 22 dopaminergic dopaminergic JJ cord-333986-xkx181ek 123 23 neurons neuron NNS cord-333986-xkx181ek 123 24 to to TO cord-333986-xkx181ek 123 25 enhance enhance VB cord-333986-xkx181ek 123 26 microglia microglia JJ cord-333986-xkx181ek 123 27 cell cell NN cord-333986-xkx181ek 123 28 activation activation NN cord-333986-xkx181ek 123 29 and and CC cord-333986-xkx181ek 123 30 neuroinflammation neuroinflammation NN cord-333986-xkx181ek 123 31 , , , cord-333986-xkx181ek 123 32 which which WDT cord-333986-xkx181ek 123 33 contribute contribute VBP cord-333986-xkx181ek 123 34 to to IN cord-333986-xkx181ek 123 35 dopaminergic dopaminergic JJ cord-333986-xkx181ek 123 36 neural neural JJ cord-333986-xkx181ek 123 37 cell cell NN cord-333986-xkx181ek 123 38 degeneration degeneration NN cord-333986-xkx181ek 123 39 [ [ -LRB- cord-333986-xkx181ek 123 40 69 69 CD cord-333986-xkx181ek 123 41 , , , cord-333986-xkx181ek 123 42 70 70 CD cord-333986-xkx181ek 123 43 ] ] -RRB- cord-333986-xkx181ek 123 44 . . . cord-333986-xkx181ek 124 1 Two two CD cord-333986-xkx181ek 124 2 hallmarks hallmark NNS cord-333986-xkx181ek 124 3 of of IN cord-333986-xkx181ek 124 4 PD PD NNP cord-333986-xkx181ek 124 5 are be VBP cord-333986-xkx181ek 124 6 the the DT cord-333986-xkx181ek 124 7 progressive progressive JJ cord-333986-xkx181ek 124 8 dopaminergic dopaminergic JJ cord-333986-xkx181ek 124 9 neuronal neuronal JJ cord-333986-xkx181ek 124 10 cell cell NN cord-333986-xkx181ek 124 11 loss loss NN cord-333986-xkx181ek 124 12 and and CC cord-333986-xkx181ek 124 13 the the DT cord-333986-xkx181ek 124 14 aggregation aggregation NN cord-333986-xkx181ek 124 15 of of IN cord-333986-xkx181ek 124 16 α α NN cord-333986-xkx181ek 124 17 - - HYPH cord-333986-xkx181ek 124 18 Syn syn NN cord-333986-xkx181ek 124 19 to to TO cord-333986-xkx181ek 124 20 form form VB cord-333986-xkx181ek 124 21 Lewy Lewy NNP cord-333986-xkx181ek 124 22 bodies body NNS cord-333986-xkx181ek 124 23 in in IN cord-333986-xkx181ek 124 24 the the DT cord-333986-xkx181ek 124 25 surviving survive VBG cord-333986-xkx181ek 124 26 affected affected JJ cord-333986-xkx181ek 124 27 neurons neuron NNS cord-333986-xkx181ek 124 28 [ [ -LRB- cord-333986-xkx181ek 124 29 71 71 CD cord-333986-xkx181ek 124 30 ] ] -RRB- cord-333986-xkx181ek 124 31 . . . cord-333986-xkx181ek 125 1 This this DT cord-333986-xkx181ek 125 2 accumulation accumulation NN cord-333986-xkx181ek 125 3 of of IN cord-333986-xkx181ek 125 4 α α NN cord-333986-xkx181ek 125 5 - - HYPH cord-333986-xkx181ek 125 6 Syn Syn NNP cord-333986-xkx181ek 125 7 has have VBZ cord-333986-xkx181ek 125 8 been be VBN cord-333986-xkx181ek 125 9 identified identify VBN cord-333986-xkx181ek 125 10 in in IN cord-333986-xkx181ek 125 11 both both CC cord-333986-xkx181ek 125 12 sporadic sporadic JJ cord-333986-xkx181ek 125 13 and and CC cord-333986-xkx181ek 125 14 familial familial JJ cord-333986-xkx181ek 125 15 PD pd NN cord-333986-xkx181ek 125 16 [ [ -LRB- cord-333986-xkx181ek 125 17 67 67 CD cord-333986-xkx181ek 125 18 ] ] -RRB- cord-333986-xkx181ek 125 19 . . . cord-333986-xkx181ek 126 1 As as IN cord-333986-xkx181ek 126 2 a a DT cord-333986-xkx181ek 126 3 consequence consequence NN cord-333986-xkx181ek 126 4 of of IN cord-333986-xkx181ek 126 5 this this DT cord-333986-xkx181ek 126 6 α α NN cord-333986-xkx181ek 126 7 - - HYPH cord-333986-xkx181ek 126 8 Syn Syn NNP cord-333986-xkx181ek 126 9 aggregation aggregation NN cord-333986-xkx181ek 126 10 , , , cord-333986-xkx181ek 126 11 a a DT cord-333986-xkx181ek 126 12 protective protective JJ cord-333986-xkx181ek 126 13 cerebral cerebral JJ cord-333986-xkx181ek 126 14 innate innate JJ cord-333986-xkx181ek 126 15 and and CC cord-333986-xkx181ek 126 16 adaptive adaptive JJ cord-333986-xkx181ek 126 17 inflammatory inflammatory JJ cord-333986-xkx181ek 126 18 response response NN cord-333986-xkx181ek 126 19 occurs occur VBZ cord-333986-xkx181ek 126 20 as as IN cord-333986-xkx181ek 126 21 activated activate VBN cord-333986-xkx181ek 126 22 pro pro JJ cord-333986-xkx181ek 126 23 - - JJ cord-333986-xkx181ek 126 24 inflammatory inflammatory JJ cord-333986-xkx181ek 126 25 microglia microglia NN cord-333986-xkx181ek 126 26 cells cell NNS cord-333986-xkx181ek 126 27 ( ( -LRB- cord-333986-xkx181ek 126 28 M1 M1 NNP cord-333986-xkx181ek 126 29 ) ) -RRB- cord-333986-xkx181ek 126 30 accumulate accumulate VBP cord-333986-xkx181ek 126 31 around around IN cord-333986-xkx181ek 126 32 the the DT cord-333986-xkx181ek 126 33 α α NN cord-333986-xkx181ek 126 34 - - HYPH cord-333986-xkx181ek 126 35 Syn syn JJ cord-333986-xkx181ek 126 36 aggregations aggregation NNS cord-333986-xkx181ek 126 37 and and CC cord-333986-xkx181ek 126 38 inflammatory inflammatory JJ cord-333986-xkx181ek 126 39 pathways pathway NNS cord-333986-xkx181ek 126 40 mediated mediate VBN cord-333986-xkx181ek 126 41 by by IN cord-333986-xkx181ek 126 42 Toll Toll NNP cord-333986-xkx181ek 126 43 - - HYPH cord-333986-xkx181ek 126 44 like like JJ cord-333986-xkx181ek 126 45 receptor-2 receptor-2 NNP cord-333986-xkx181ek 126 46 ( ( -LRB- cord-333986-xkx181ek 126 47 TLR2 TLR2 NNP cord-333986-xkx181ek 126 48 ) ) -RRB- cord-333986-xkx181ek 126 49 and and CC cord-333986-xkx181ek 126 50 the the DT cord-333986-xkx181ek 126 51 activation activation NN cord-333986-xkx181ek 126 52 of of IN cord-333986-xkx181ek 126 53 myeloid myeloid JJ cord-333986-xkx181ek 126 54 differentiation differentiation NN cord-333986-xkx181ek 126 55 factor-88 factor-88 NN cord-333986-xkx181ek 126 56 ( ( -LRB- cord-333986-xkx181ek 126 57 MyD88 MyD88 NNP cord-333986-xkx181ek 126 58 ) ) -RRB- cord-333986-xkx181ek 126 59 , , , cord-333986-xkx181ek 126 60 nuclear nuclear JJ cord-333986-xkx181ek 126 61 transcription transcription NN cord-333986-xkx181ek 126 62 factor factor NN cord-333986-xkx181ek 126 63 - - HYPH cord-333986-xkx181ek 126 64 kB kB NNP cord-333986-xkx181ek 126 65 ( ( -LRB- cord-333986-xkx181ek 126 66 NF NF NNP cord-333986-xkx181ek 126 67 - - HYPH cord-333986-xkx181ek 126 68 kB kB NNP cord-333986-xkx181ek 126 69 ) ) -RRB- cord-333986-xkx181ek 126 70 , , , cord-333986-xkx181ek 126 71 TRAF6 TRAF6 NNP cord-333986-xkx181ek 126 72 , , , cord-333986-xkx181ek 126 73 and and CC cord-333986-xkx181ek 126 74 TAK-1 TAK-1 NNP cord-333986-xkx181ek 126 75 [ [ -LRB- cord-333986-xkx181ek 126 76 72 72 CD cord-333986-xkx181ek 126 77 ] ] -RRB- cord-333986-xkx181ek 126 78 . . . cord-333986-xkx181ek 127 1 Given give VBN cord-333986-xkx181ek 127 2 the the DT cord-333986-xkx181ek 127 3 role role NN cord-333986-xkx181ek 127 4 neuroinflammation neuroinflammation NN cord-333986-xkx181ek 127 5 plays play VBZ cord-333986-xkx181ek 127 6 in in IN cord-333986-xkx181ek 127 7 the the DT cord-333986-xkx181ek 127 8 initiation initiation NN cord-333986-xkx181ek 127 9 , , , cord-333986-xkx181ek 127 10 maintenance maintenance NN cord-333986-xkx181ek 127 11 , , , cord-333986-xkx181ek 127 12 and and CC cord-333986-xkx181ek 127 13 progression progression NN cord-333986-xkx181ek 127 14 of of IN cord-333986-xkx181ek 127 15 PD PD NNP cord-333986-xkx181ek 127 16 , , , cord-333986-xkx181ek 127 17 there there EX cord-333986-xkx181ek 127 18 is be VBZ cord-333986-xkx181ek 127 19 a a DT cord-333986-xkx181ek 127 20 need need NN cord-333986-xkx181ek 127 21 for for IN cord-333986-xkx181ek 127 22 the the DT cord-333986-xkx181ek 127 23 development development NN cord-333986-xkx181ek 127 24 of of IN cord-333986-xkx181ek 127 25 neuroprotective neuroprotective JJ cord-333986-xkx181ek 127 26 therapies therapy NNS cord-333986-xkx181ek 127 27 that that WDT cord-333986-xkx181ek 127 28 target target VBP cord-333986-xkx181ek 127 29 the the DT cord-333986-xkx181ek 127 30 inflammatory inflammatory JJ cord-333986-xkx181ek 127 31 pathways pathway NNS cord-333986-xkx181ek 127 32 . . . cord-333986-xkx181ek 128 1 Previous previous JJ cord-333986-xkx181ek 128 2 studies study NNS cord-333986-xkx181ek 128 3 illustrating illustrate VBG cord-333986-xkx181ek 128 4 the the DT cord-333986-xkx181ek 128 5 anti anti JJ cord-333986-xkx181ek 128 6 - - JJ cord-333986-xkx181ek 128 7 inflammatory inflammatory JJ cord-333986-xkx181ek 128 8 effect effect NN cord-333986-xkx181ek 128 9 of of IN cord-333986-xkx181ek 128 10 moderate moderate JJ cord-333986-xkx181ek 128 11 to to IN cord-333986-xkx181ek 128 12 vigorous vigorous JJ cord-333986-xkx181ek 128 13 exercise exercise NN cord-333986-xkx181ek 128 14 have have VBP cord-333986-xkx181ek 128 15 led lead VBN cord-333986-xkx181ek 128 16 to to TO cord-333986-xkx181ek 128 17 research research VB cord-333986-xkx181ek 128 18 into into IN cord-333986-xkx181ek 128 19 exercise exercise NN cord-333986-xkx181ek 128 20 training training NN cord-333986-xkx181ek 128 21 as as IN cord-333986-xkx181ek 128 22 a a DT cord-333986-xkx181ek 128 23 potential potential JJ cord-333986-xkx181ek 128 24 therapy therapy NN cord-333986-xkx181ek 128 25 . . . cord-333986-xkx181ek 129 1 Palasz Palasz NNP cord-333986-xkx181ek 129 2 et et FW cord-333986-xkx181ek 129 3 al al NNP cord-333986-xkx181ek 129 4 . . NNP cord-333986-xkx181ek 129 5 investigated investigate VBD cord-333986-xkx181ek 129 6 the the DT cord-333986-xkx181ek 129 7 effect effect NN cord-333986-xkx181ek 129 8 of of IN cord-333986-xkx181ek 129 9 long long JJ cord-333986-xkx181ek 129 10 - - HYPH cord-333986-xkx181ek 129 11 term term NN cord-333986-xkx181ek 129 12 physical physical JJ cord-333986-xkx181ek 129 13 activity activity NN cord-333986-xkx181ek 129 14 initiated initiate VBN cord-333986-xkx181ek 129 15 before before RB cord-333986-xkx181ek 129 16 and and CC cord-333986-xkx181ek 129 17 after after IN cord-333986-xkx181ek 129 18 PD PD NNP cord-333986-xkx181ek 129 19 induction induction NN cord-333986-xkx181ek 129 20 in in IN cord-333986-xkx181ek 129 21 the the DT cord-333986-xkx181ek 129 22 MPTP MPTP NNP cord-333986-xkx181ek 129 23 - - HYPH cord-333986-xkx181ek 129 24 mouse mouse NN cord-333986-xkx181ek 129 25 model model NN cord-333986-xkx181ek 129 26 [ [ -LRB- cord-333986-xkx181ek 129 27 73 73 CD cord-333986-xkx181ek 129 28 ] ] -RRB- cord-333986-xkx181ek 129 29 . . . cord-333986-xkx181ek 130 1 The the DT cord-333986-xkx181ek 130 2 treadmill treadmill NN cord-333986-xkx181ek 130 3 exercise exercise NN cord-333986-xkx181ek 130 4 consisted consist VBD cord-333986-xkx181ek 130 5 of of IN cord-333986-xkx181ek 130 6 the the DT cord-333986-xkx181ek 130 7 mice mouse NNS cord-333986-xkx181ek 130 8 running run VBG cord-333986-xkx181ek 130 9 at at IN cord-333986-xkx181ek 130 10 10 10 CD cord-333986-xkx181ek 130 11 cm cm NNS cord-333986-xkx181ek 130 12 / / SYM cord-333986-xkx181ek 130 13 s s NN cord-333986-xkx181ek 130 14 for for IN cord-333986-xkx181ek 130 15 5 5 CD cord-333986-xkx181ek 130 16 min min NN cord-333986-xkx181ek 130 17 , , , cord-333986-xkx181ek 130 18 15 15 CD cord-333986-xkx181ek 130 19 cm cm NNS cord-333986-xkx181ek 130 20 / / SYM cord-333986-xkx181ek 130 21 s s NN cord-333986-xkx181ek 130 22 for for IN cord-333986-xkx181ek 130 23 5 5 CD cord-333986-xkx181ek 130 24 min min NN cord-333986-xkx181ek 130 25 , , , cord-333986-xkx181ek 130 26 20 20 CD cord-333986-xkx181ek 130 27 cm cm NNS cord-333986-xkx181ek 130 28 / / SYM cord-333986-xkx181ek 130 29 s s NN cord-333986-xkx181ek 130 30 for for IN cord-333986-xkx181ek 130 31 20 20 CD cord-333986-xkx181ek 130 32 min min NN cord-333986-xkx181ek 130 33 , , , cord-333986-xkx181ek 130 34 25 25 CD cord-333986-xkx181ek 130 35 cm cm NNS cord-333986-xkx181ek 130 36 / / SYM cord-333986-xkx181ek 130 37 s s NN cord-333986-xkx181ek 130 38 for for IN cord-333986-xkx181ek 130 39 5 5 CD cord-333986-xkx181ek 130 40 min min NN cord-333986-xkx181ek 130 41 , , , cord-333986-xkx181ek 130 42 and and CC cord-333986-xkx181ek 130 43 20 20 CD cord-333986-xkx181ek 130 44 cm cm NNS cord-333986-xkx181ek 130 45 / / SYM cord-333986-xkx181ek 130 46 s s NN cord-333986-xkx181ek 130 47 for for IN cord-333986-xkx181ek 130 48 5 5 CD cord-333986-xkx181ek 130 49 min min NN cord-333986-xkx181ek 130 50 . . . cord-333986-xkx181ek 131 1 This this DT cord-333986-xkx181ek 131 2 protocol protocol NN cord-333986-xkx181ek 131 3 is be VBZ cord-333986-xkx181ek 131 4 moderate moderate JJ cord-333986-xkx181ek 131 5 - - HYPH cord-333986-xkx181ek 131 6 to to IN cord-333986-xkx181ek 131 7 high high JJ cord-333986-xkx181ek 131 8 - - HYPH cord-333986-xkx181ek 131 9 intensity intensity NN cord-333986-xkx181ek 131 10 exercise exercise NN cord-333986-xkx181ek 131 11 based base VBN cord-333986-xkx181ek 131 12 on on IN cord-333986-xkx181ek 131 13 the the DT cord-333986-xkx181ek 131 14 definition definition NN cord-333986-xkx181ek 131 15 of of IN cord-333986-xkx181ek 131 16 moderate moderate JJ cord-333986-xkx181ek 131 17 treadmill treadmill NN cord-333986-xkx181ek 131 18 exercise exercise NN cord-333986-xkx181ek 131 19 in in IN cord-333986-xkx181ek 131 20 mice mouse NNS cord-333986-xkx181ek 131 21 [ [ -LRB- cord-333986-xkx181ek 131 22 74 74 CD cord-333986-xkx181ek 131 23 ] ] -RRB- cord-333986-xkx181ek 131 24 [ [ -LRB- cord-333986-xkx181ek 131 25 75 75 CD cord-333986-xkx181ek 131 26 ] ] -RRB- cord-333986-xkx181ek 131 27 [ [ -LRB- cord-333986-xkx181ek 131 28 76 76 CD cord-333986-xkx181ek 131 29 ] ] -RRB- cord-333986-xkx181ek 131 30 . . . cord-333986-xkx181ek 132 1 They -PRON- PRP cord-333986-xkx181ek 132 2 reported report VBD cord-333986-xkx181ek 132 3 that that IN cord-333986-xkx181ek 132 4 in in IN cord-333986-xkx181ek 132 5 both both CC cord-333986-xkx181ek 132 6 early early JJ cord-333986-xkx181ek 132 7 and and CC cord-333986-xkx181ek 132 8 late late JJ cord-333986-xkx181ek 132 9 - - HYPH cord-333986-xkx181ek 132 10 onset onset NN cord-333986-xkx181ek 132 11 exercise exercise NN cord-333986-xkx181ek 132 12 ( ( -LRB- cord-333986-xkx181ek 132 13 treadmill treadmill NN cord-333986-xkx181ek 132 14 ) ) -RRB- cord-333986-xkx181ek 132 15 training training NN cord-333986-xkx181ek 132 16 , , , cord-333986-xkx181ek 132 17 there there EX cord-333986-xkx181ek 132 18 was be VBD cord-333986-xkx181ek 132 19 ( ( -LRB- cord-333986-xkx181ek 132 20 a a DT cord-333986-xkx181ek 132 21 ) ) -RRB- cord-333986-xkx181ek 132 22 preservation preservation NN cord-333986-xkx181ek 132 23 of of IN cord-333986-xkx181ek 132 24 dopaminergic dopaminergic JJ cord-333986-xkx181ek 132 25 neurons neuron NNS cord-333986-xkx181ek 132 26 in in IN cord-333986-xkx181ek 132 27 substantia substantia NNP cord-333986-xkx181ek 132 28 nigra nigra NNP cord-333986-xkx181ek 132 29 pars pars NNP cord-333986-xkx181ek 132 30 compacta compacta NN cord-333986-xkx181ek 132 31 ( ( -LRB- cord-333986-xkx181ek 132 32 SNpc SNpc NNP cord-333986-xkx181ek 132 33 ) ) -RRB- cord-333986-xkx181ek 132 34 and and CC cord-333986-xkx181ek 132 35 ventral ventral JJ cord-333986-xkx181ek 132 36 tegmental tegmental JJ cord-333986-xkx181ek 132 37 area area NN cord-333986-xkx181ek 132 38 ( ( -LRB- cord-333986-xkx181ek 132 39 VTA VTA NNP cord-333986-xkx181ek 132 40 ) ) -RRB- cord-333986-xkx181ek 132 41 , , , cord-333986-xkx181ek 132 42 ( ( -LRB- cord-333986-xkx181ek 132 43 b b NN cord-333986-xkx181ek 132 44 ) ) -RRB- cord-333986-xkx181ek 132 45 an an DT cord-333986-xkx181ek 132 46 increase increase NN cord-333986-xkx181ek 132 47 in in IN cord-333986-xkx181ek 132 48 brain brain NN cord-333986-xkx181ek 132 49 - - HYPH cord-333986-xkx181ek 132 50 derived derive VBN cord-333986-xkx181ek 132 51 neurotrophic neurotrophic NN cord-333986-xkx181ek 132 52 factor factor NN cord-333986-xkx181ek 132 53 in in IN cord-333986-xkx181ek 132 54 the the DT cord-333986-xkx181ek 132 55 midbrain midbrain NN cord-333986-xkx181ek 132 56 and and CC cord-333986-xkx181ek 132 57 glial glial JJ cord-333986-xkx181ek 132 58 cell cell NN cord-333986-xkx181ek 132 59 line line NN cord-333986-xkx181ek 132 60 - - HYPH cord-333986-xkx181ek 132 61 derived derive VBN cord-333986-xkx181ek 132 62 neurotrophic neurotrophic NN cord-333986-xkx181ek 132 63 factor factor NN cord-333986-xkx181ek 132 64 in in IN cord-333986-xkx181ek 132 65 the the DT cord-333986-xkx181ek 132 66 striatum striatum NN cord-333986-xkx181ek 132 67 , , , cord-333986-xkx181ek 132 68 and and CC cord-333986-xkx181ek 132 69 ( ( -LRB- cord-333986-xkx181ek 132 70 c c NN cord-333986-xkx181ek 132 71 ) ) -RRB- cord-333986-xkx181ek 132 72 mitigation mitigation NN cord-333986-xkx181ek 132 73 of of IN cord-333986-xkx181ek 132 74 the the DT cord-333986-xkx181ek 132 75 pro pro JJ cord-333986-xkx181ek 132 76 - - JJ cord-333986-xkx181ek 132 77 inflammatory inflammatory JJ cord-333986-xkx181ek 132 78 response response NN cord-333986-xkx181ek 132 79 in in IN cord-333986-xkx181ek 132 80 the the DT cord-333986-xkx181ek 132 81 SNpc SNpc NNP cord-333986-xkx181ek 132 82 and and CC cord-333986-xkx181ek 132 83 VTA VTA NNP cord-333986-xkx181ek 132 84 [ [ -LRB- cord-333986-xkx181ek 132 85 73 73 CD cord-333986-xkx181ek 132 86 ] ] -RRB- cord-333986-xkx181ek 132 87 . . . cord-333986-xkx181ek 133 1 Zhou Zhou NNP cord-333986-xkx181ek 133 2 et et NNP cord-333986-xkx181ek 133 3 al al NNP cord-333986-xkx181ek 133 4 . . NNP cord-333986-xkx181ek 133 5 investigated investigate VBD cord-333986-xkx181ek 133 6 the the DT cord-333986-xkx181ek 133 7 neuroprotective neuroprotective JJ cord-333986-xkx181ek 133 8 effect effect NN cord-333986-xkx181ek 133 9 of of IN cord-333986-xkx181ek 133 10 a a DT cord-333986-xkx181ek 133 11 running run VBG cord-333986-xkx181ek 133 12 wheel wheel NN cord-333986-xkx181ek 133 13 exercise exercise NN cord-333986-xkx181ek 133 14 in in IN cord-333986-xkx181ek 133 15 PD PD NNP cord-333986-xkx181ek 133 16 mouse mouse NN cord-333986-xkx181ek 133 17 models model NNS cord-333986-xkx181ek 133 18 [ [ -LRB- cord-333986-xkx181ek 133 19 77 77 CD cord-333986-xkx181ek 133 20 ] ] -RRB- cord-333986-xkx181ek 133 21 . . . cord-333986-xkx181ek 134 1 The the DT cord-333986-xkx181ek 134 2 mice mouse NNS cord-333986-xkx181ek 134 3 had have VBD cord-333986-xkx181ek 134 4 open open JJ cord-333986-xkx181ek 134 5 running run VBG cord-333986-xkx181ek 134 6 wheel wheel NN cord-333986-xkx181ek 134 7 access access NN cord-333986-xkx181ek 134 8 for for IN cord-333986-xkx181ek 134 9 three three CD cord-333986-xkx181ek 134 10 months month NNS cord-333986-xkx181ek 134 11 ; ; : cord-333986-xkx181ek 134 12 it -PRON- PRP cord-333986-xkx181ek 134 13 could could MD cord-333986-xkx181ek 134 14 be be VB cord-333986-xkx181ek 134 15 calculated calculate VBN cord-333986-xkx181ek 134 16 that that IN cord-333986-xkx181ek 134 17 the the DT cord-333986-xkx181ek 134 18 mice mice NN cord-333986-xkx181ek 134 19 ran run VBD cord-333986-xkx181ek 134 20 5 5 CD cord-333986-xkx181ek 134 21 miles mile NNS cord-333986-xkx181ek 134 22 / / SYM cord-333986-xkx181ek 134 23 day day NN cord-333986-xkx181ek 134 24 . . . cord-333986-xkx181ek 135 1 Their -PRON- PRP$ cord-333986-xkx181ek 135 2 results result NNS cord-333986-xkx181ek 135 3 showed show VBD cord-333986-xkx181ek 135 4 that that IN cord-333986-xkx181ek 135 5 ( ( -LRB- cord-333986-xkx181ek 135 6 i i NN cord-333986-xkx181ek 135 7 ) ) -RRB- cord-333986-xkx181ek 135 8 exercise exercise VBP cord-333986-xkx181ek 135 9 significantly significantly RB cord-333986-xkx181ek 135 10 improves improve VBZ cord-333986-xkx181ek 135 11 motor motor NN cord-333986-xkx181ek 135 12 and and CC cord-333986-xkx181ek 135 13 cognitive cognitive JJ cord-333986-xkx181ek 135 14 function function NN cord-333986-xkx181ek 135 15 ; ; : cord-333986-xkx181ek 135 16 ( ( -LRB- cord-333986-xkx181ek 135 17 ii ii NN cord-333986-xkx181ek 135 18 ) ) -RRB- cord-333986-xkx181ek 135 19 prevents prevent VBZ cord-333986-xkx181ek 135 20 α α NN cord-333986-xkx181ek 135 21 - - HYPH cord-333986-xkx181ek 135 22 Syn Syn NNP cord-333986-xkx181ek 135 23 oligomer oligomer NNP cord-333986-xkx181ek 135 24 accumulation accumulation NN cord-333986-xkx181ek 135 25 in in IN cord-333986-xkx181ek 135 26 the the DT cord-333986-xkx181ek 135 27 brain brain NN cord-333986-xkx181ek 135 28 while while IN cord-333986-xkx181ek 135 29 increasing increase VBG cord-333986-xkx181ek 135 30 monomers monomer NNS cord-333986-xkx181ek 135 31 and and CC cord-333986-xkx181ek 135 32 dimers dimer NNS cord-333986-xkx181ek 135 33 in in IN cord-333986-xkx181ek 135 34 plasma plasma NN cord-333986-xkx181ek 135 35 ; ; : cord-333986-xkx181ek 135 36 and and CC cord-333986-xkx181ek 135 37 ( ( -LRB- cord-333986-xkx181ek 135 38 iii iii NN cord-333986-xkx181ek 135 39 ) ) -RRB- cord-333986-xkx181ek 135 40 significantly significantly RB cord-333986-xkx181ek 135 41 increases increase VBZ cord-333986-xkx181ek 135 42 levels level NNS cord-333986-xkx181ek 135 43 of of IN cord-333986-xkx181ek 135 44 DJ-1 DJ-1 NNP cord-333986-xkx181ek 135 45 , , , cord-333986-xkx181ek 135 46 Hsp70 Hsp70 NNP cord-333986-xkx181ek 135 47 , , , cord-333986-xkx181ek 135 48 and and CC cord-333986-xkx181ek 135 49 BDNF BDNF NNP cord-333986-xkx181ek 135 50 , , , cord-333986-xkx181ek 135 51 which which WDT cord-333986-xkx181ek 135 52 are be VBP cord-333986-xkx181ek 135 53 neuroprotective neuroprotective JJ cord-333986-xkx181ek 135 54 substances substance NNS cord-333986-xkx181ek 135 55 [ [ -LRB- cord-333986-xkx181ek 135 56 77 77 CD cord-333986-xkx181ek 135 57 ] ] -RRB- cord-333986-xkx181ek 135 58 . . . cord-333986-xkx181ek 136 1 Two two CD cord-333986-xkx181ek 136 2 other other JJ cord-333986-xkx181ek 136 3 studies study NNS cord-333986-xkx181ek 136 4 investigating investigate VBG cord-333986-xkx181ek 136 5 the the DT cord-333986-xkx181ek 136 6 neuroprotective neuroprotective JJ cord-333986-xkx181ek 136 7 effects effect NNS cord-333986-xkx181ek 136 8 of of IN cord-333986-xkx181ek 136 9 exercise exercise NN cord-333986-xkx181ek 136 10 in in IN cord-333986-xkx181ek 136 11 mice mouse NNS cord-333986-xkx181ek 136 12 PD PD NNP cord-333986-xkx181ek 136 13 induction induction NN cord-333986-xkx181ek 136 14 models model NNS cord-333986-xkx181ek 136 15 collectively collectively RB cord-333986-xkx181ek 136 16 found find VBN cord-333986-xkx181ek 136 17 in in IN cord-333986-xkx181ek 136 18 swimming swim VBG cord-333986-xkx181ek 136 19 [ [ -LRB- cord-333986-xkx181ek 136 20 78 78 CD cord-333986-xkx181ek 136 21 ] ] -RRB- cord-333986-xkx181ek 136 22 and and CC cord-333986-xkx181ek 136 23 endurance endurance NN cord-333986-xkx181ek 136 24 exercise exercise NN cord-333986-xkx181ek 136 25 [ [ -LRB- cord-333986-xkx181ek 136 26 72 72 CD cord-333986-xkx181ek 136 27 ] ] -RRB- cord-333986-xkx181ek 136 28 groups group NNS cord-333986-xkx181ek 136 29 : : : cord-333986-xkx181ek 136 30 ( ( -LRB- cord-333986-xkx181ek 136 31 i i NN cord-333986-xkx181ek 136 32 ) ) -RRB- cord-333986-xkx181ek 136 33 decreased decrease VBD cord-333986-xkx181ek 136 34 levels level NNS cord-333986-xkx181ek 136 35 of of IN cord-333986-xkx181ek 136 36 reactive reactive JJ cord-333986-xkx181ek 136 37 oxygen oxygen NN cord-333986-xkx181ek 136 38 species specie NNS cord-333986-xkx181ek 136 39 , , , cord-333986-xkx181ek 136 40 ( ( -LRB- cord-333986-xkx181ek 136 41 ii ii NN cord-333986-xkx181ek 136 42 ) ) -RRB- cord-333986-xkx181ek 136 43 significant significant JJ cord-333986-xkx181ek 136 44 reductions reduction NNS cord-333986-xkx181ek 136 45 in in IN cord-333986-xkx181ek 136 46 α α NN cord-333986-xkx181ek 136 47 - - HYPH cord-333986-xkx181ek 136 48 Syn syn NN cord-333986-xkx181ek 136 49 protein protein NN cord-333986-xkx181ek 136 50 along along IN cord-333986-xkx181ek 136 51 with with IN cord-333986-xkx181ek 136 52 diminished diminished JJ cord-333986-xkx181ek 136 53 pro pro JJ cord-333986-xkx181ek 136 54 - - JJ cord-333986-xkx181ek 136 55 inflammatory inflammatory JJ cord-333986-xkx181ek 136 56 cytokines cytokine NNS cord-333986-xkx181ek 136 57 ( ( -LRB- cord-333986-xkx181ek 136 58 TNF TNF NNP cord-333986-xkx181ek 136 59 - - HYPH cord-333986-xkx181ek 136 60 α α NNP cord-333986-xkx181ek 136 61 and and CC cord-333986-xkx181ek 136 62 IL IL NNP cord-333986-xkx181ek 136 63 - - HYPH cord-333986-xkx181ek 136 64 β β NNP cord-333986-xkx181ek 136 65 ) ) -RRB- cord-333986-xkx181ek 136 66 , , , cord-333986-xkx181ek 136 67 and and CC cord-333986-xkx181ek 136 68 ( ( -LRB- cord-333986-xkx181ek 136 69 iii iii NN cord-333986-xkx181ek 136 70 ) ) -RRB- cord-333986-xkx181ek 136 71 decreased decrease VBD cord-333986-xkx181ek 136 72 activation activation NN cord-333986-xkx181ek 136 73 of of IN cord-333986-xkx181ek 136 74 TLR2 TLR2 NNP cord-333986-xkx181ek 136 75 and and CC cord-333986-xkx181ek 136 76 its -PRON- PRP$ cord-333986-xkx181ek 136 77 subsequent subsequent JJ cord-333986-xkx181ek 136 78 downstream downstream NN cord-333986-xkx181ek 136 79 signaling signal VBG cord-333986-xkx181ek 136 80 cascades cascade NNS cord-333986-xkx181ek 136 81 ( ( -LRB- cord-333986-xkx181ek 136 82 MyD88 MyD88 NNP cord-333986-xkx181ek 136 83 , , , cord-333986-xkx181ek 136 84 TRAF6 TRAF6 NNP cord-333986-xkx181ek 136 85 , , , cord-333986-xkx181ek 136 86 and and CC cord-333986-xkx181ek 136 87 TAK1 TAK1 NNP cord-333986-xkx181ek 136 88 ) ) -RRB- cord-333986-xkx181ek 136 89 [ [ -LRB- cord-333986-xkx181ek 136 90 72 72 CD cord-333986-xkx181ek 136 91 , , , cord-333986-xkx181ek 136 92 78 78 CD cord-333986-xkx181ek 136 93 ] ] -RRB- cord-333986-xkx181ek 136 94 . . . cord-333986-xkx181ek 137 1 The the DT cord-333986-xkx181ek 137 2 treadmill treadmill NN cord-333986-xkx181ek 137 3 exercise exercise NN cord-333986-xkx181ek 137 4 for for IN cord-333986-xkx181ek 137 5 this this DT cord-333986-xkx181ek 137 6 study study NN cord-333986-xkx181ek 137 7 occurred occur VBD cord-333986-xkx181ek 137 8 at at IN cord-333986-xkx181ek 137 9 10 10 CD cord-333986-xkx181ek 137 10 m m NN cord-333986-xkx181ek 137 11 / / SYM cord-333986-xkx181ek 137 12 min min NN cord-333986-xkx181ek 137 13 for for IN cord-333986-xkx181ek 137 14 60 60 CD cord-333986-xkx181ek 137 15 min min NN cord-333986-xkx181ek 137 16 / / SYM cord-333986-xkx181ek 137 17 day day NN cord-333986-xkx181ek 137 18 [ [ -LRB- cord-333986-xkx181ek 137 19 72 72 CD cord-333986-xkx181ek 137 20 ] ] -RRB- cord-333986-xkx181ek 137 21 . . . cord-333986-xkx181ek 138 1 This this DT cord-333986-xkx181ek 138 2 is be VBZ cord-333986-xkx181ek 138 3 moderate moderate JJ cord-333986-xkx181ek 138 4 intensity intensity NN cord-333986-xkx181ek 138 5 based base VBN cord-333986-xkx181ek 138 6 on on IN cord-333986-xkx181ek 138 7 the the DT cord-333986-xkx181ek 138 8 definition definition NN cord-333986-xkx181ek 138 9 of of IN cord-333986-xkx181ek 138 10 moderate moderate JJ cord-333986-xkx181ek 138 11 treadmill treadmill NN cord-333986-xkx181ek 138 12 exercise exercise NN cord-333986-xkx181ek 138 13 in in IN cord-333986-xkx181ek 138 14 mice mouse NNS cord-333986-xkx181ek 138 15 [ [ -LRB- cord-333986-xkx181ek 138 16 74 74 CD cord-333986-xkx181ek 138 17 ] ] -RRB- cord-333986-xkx181ek 138 18 [ [ -LRB- cord-333986-xkx181ek 138 19 75 75 CD cord-333986-xkx181ek 138 20 ] ] -RRB- cord-333986-xkx181ek 138 21 [ [ -LRB- cord-333986-xkx181ek 138 22 76 76 CD cord-333986-xkx181ek 138 23 ] ] -RRB- cord-333986-xkx181ek 138 24 . . . cord-333986-xkx181ek 139 1 The the DT cord-333986-xkx181ek 139 2 results result NNS cord-333986-xkx181ek 139 3 of of IN cord-333986-xkx181ek 139 4 Jang Jang NNP cord-333986-xkx181ek 139 5 et et FW cord-333986-xkx181ek 139 6 al al NNP cord-333986-xkx181ek 139 7 . . . cord-333986-xkx181ek 140 1 [ [ -LRB- cord-333986-xkx181ek 140 2 72 72 CD cord-333986-xkx181ek 140 3 ] ] -RRB- cord-333986-xkx181ek 140 4 imply imply VBP cord-333986-xkx181ek 140 5 that that DT cord-333986-xkx181ek 140 6 exercise exercise NN cord-333986-xkx181ek 140 7 is be VBZ cord-333986-xkx181ek 140 8 neuroprotective neuroprotective JJ cord-333986-xkx181ek 140 9 in in IN cord-333986-xkx181ek 140 10 PD PD NNP cord-333986-xkx181ek 140 11 from from IN cord-333986-xkx181ek 140 12 the the DT cord-333986-xkx181ek 140 13 reduction reduction NN cord-333986-xkx181ek 140 14 in in IN cord-333986-xkx181ek 140 15 α α NN cord-333986-xkx181ek 140 16 - - HYPH cord-333986-xkx181ek 140 17 Syn Syn NNP cord-333986-xkx181ek 140 18 that that WDT cord-333986-xkx181ek 140 19 reduces reduce VBZ cord-333986-xkx181ek 140 20 inflammation inflammation NN cord-333986-xkx181ek 140 21 . . . cord-333986-xkx181ek 141 1 Goes go VBZ cord-333986-xkx181ek 141 2 et et NNP cord-333986-xkx181ek 141 3 al al NNP cord-333986-xkx181ek 141 4 . . . cord-333986-xkx181ek 142 1 [ [ -LRB- cord-333986-xkx181ek 142 2 78 78 CD cord-333986-xkx181ek 142 3 ] ] -RRB- cord-333986-xkx181ek 142 4 suggests suggest VBZ cord-333986-xkx181ek 142 5 that that DT cord-333986-xkx181ek 142 6 exercise exercise NN cord-333986-xkx181ek 142 7 promotes promote VBZ cord-333986-xkx181ek 142 8 both both DT cord-333986-xkx181ek 142 9 anti anti JJ cord-333986-xkx181ek 142 10 - - JJ cord-333986-xkx181ek 142 11 oxidation oxidation JJ cord-333986-xkx181ek 142 12 and and CC cord-333986-xkx181ek 142 13 anti anti JJ cord-333986-xkx181ek 142 14 - - JJ cord-333986-xkx181ek 142 15 inflammatory inflammatory JJ cord-333986-xkx181ek 142 16 properties property NNS cord-333986-xkx181ek 142 17 in in IN cord-333986-xkx181ek 142 18 chemical chemical NN cord-333986-xkx181ek 142 19 - - HYPH cord-333986-xkx181ek 142 20 induced induce VBN cord-333986-xkx181ek 142 21 models model NNS cord-333986-xkx181ek 142 22 of of IN cord-333986-xkx181ek 142 23 PD PD NNP cord-333986-xkx181ek 142 24 . . . cord-333986-xkx181ek 143 1 These these DT cord-333986-xkx181ek 143 2 animal animal NN cord-333986-xkx181ek 143 3 models model NNS cord-333986-xkx181ek 143 4 collectively collectively RB cord-333986-xkx181ek 143 5 reinforce reinforce VBP cord-333986-xkx181ek 143 6 the the DT cord-333986-xkx181ek 143 7 evidence evidence NN cord-333986-xkx181ek 143 8 that that DT cord-333986-xkx181ek 143 9 exercise exercise NN cord-333986-xkx181ek 143 10 's 's POS cord-333986-xkx181ek 143 11 anti anti JJ cord-333986-xkx181ek 143 12 - - JJ cord-333986-xkx181ek 143 13 inflammatory inflammatory JJ cord-333986-xkx181ek 143 14 properties property NNS cord-333986-xkx181ek 143 15 can can MD cord-333986-xkx181ek 143 16 potentially potentially RB cord-333986-xkx181ek 143 17 be be VB cord-333986-xkx181ek 143 18 harnessed harness VBN cord-333986-xkx181ek 143 19 in in IN cord-333986-xkx181ek 143 20 a a DT cord-333986-xkx181ek 143 21 neuroprotective neuroprotective JJ cord-333986-xkx181ek 143 22 role role NN cord-333986-xkx181ek 143 23 , , , cord-333986-xkx181ek 143 24 mitigating mitigate VBG cord-333986-xkx181ek 143 25 the the DT cord-333986-xkx181ek 143 26 immune immune JJ cord-333986-xkx181ek 143 27 system system NN cord-333986-xkx181ek 143 28 's 's POS cord-333986-xkx181ek 143 29 neuroinflammation neuroinflammation NN cord-333986-xkx181ek 143 30 that that WDT cord-333986-xkx181ek 143 31 is be VBZ cord-333986-xkx181ek 143 32 characteristic characteristic JJ cord-333986-xkx181ek 143 33 of of IN cord-333986-xkx181ek 143 34 PD PD NNP cord-333986-xkx181ek 143 35 . . . cord-333986-xkx181ek 144 1 Importantly importantly RB cord-333986-xkx181ek 144 2 , , , cord-333986-xkx181ek 144 3 mouse mouse NN cord-333986-xkx181ek 144 4 models model NNS cord-333986-xkx181ek 144 5 provide provide VBP cord-333986-xkx181ek 144 6 mechanistic mechanistic JJ cord-333986-xkx181ek 144 7 insight insight NN cord-333986-xkx181ek 144 8 into into IN cord-333986-xkx181ek 144 9 how how WRB cord-333986-xkx181ek 144 10 exercise exercise NN cord-333986-xkx181ek 144 11 promotes promote VBZ cord-333986-xkx181ek 144 12 change change NN cord-333986-xkx181ek 144 13 at at IN cord-333986-xkx181ek 144 14 the the DT cord-333986-xkx181ek 144 15 molecular molecular JJ cord-333986-xkx181ek 144 16 , , , cord-333986-xkx181ek 144 17 cellular cellular JJ cord-333986-xkx181ek 144 18 , , , cord-333986-xkx181ek 144 19 and and CC cord-333986-xkx181ek 144 20 neural neural JJ cord-333986-xkx181ek 144 21 network network NN cord-333986-xkx181ek 144 22 levels level NNS cord-333986-xkx181ek 144 23 [ [ -LRB- cord-333986-xkx181ek 144 24 79 79 CD cord-333986-xkx181ek 144 25 ] ] -RRB- cord-333986-xkx181ek 144 26 . . . cord-333986-xkx181ek 145 1 They -PRON- PRP cord-333986-xkx181ek 145 2 emphasize emphasize VBP cord-333986-xkx181ek 145 3 the the DT cord-333986-xkx181ek 145 4 importance importance NN cord-333986-xkx181ek 145 5 of of IN cord-333986-xkx181ek 145 6 additional additional JJ cord-333986-xkx181ek 145 7 studies study NNS cord-333986-xkx181ek 145 8 to to TO cord-333986-xkx181ek 145 9 better better RB cord-333986-xkx181ek 145 10 understand understand VB cord-333986-xkx181ek 145 11 the the DT cord-333986-xkx181ek 145 12 mechanistic mechanistic JJ cord-333986-xkx181ek 145 13 changes change NNS cord-333986-xkx181ek 145 14 induced induce VBN cord-333986-xkx181ek 145 15 by by IN cord-333986-xkx181ek 145 16 exercise exercise NN cord-333986-xkx181ek 145 17 in in IN cord-333986-xkx181ek 145 18 humans human NNS cord-333986-xkx181ek 145 19 as as RB cord-333986-xkx181ek 145 20 well well RB cord-333986-xkx181ek 145 21 . . . cord-333986-xkx181ek 146 1 In in IN cord-333986-xkx181ek 146 2 human human JJ cord-333986-xkx181ek 146 3 models model NNS cord-333986-xkx181ek 146 4 , , , cord-333986-xkx181ek 146 5 it -PRON- PRP cord-333986-xkx181ek 146 6 has have VBZ cord-333986-xkx181ek 146 7 been be VBN cord-333986-xkx181ek 146 8 shown show VBN cord-333986-xkx181ek 146 9 that that IN cord-333986-xkx181ek 146 10 sustained sustain VBD cord-333986-xkx181ek 146 11 moderate moderate JJ cord-333986-xkx181ek 146 12 exercise exercise NN cord-333986-xkx181ek 146 13 can can MD cord-333986-xkx181ek 146 14 improve improve VB cord-333986-xkx181ek 146 15 QoL qol NN cord-333986-xkx181ek 146 16 in in IN cord-333986-xkx181ek 146 17 PD PD NNP cord-333986-xkx181ek 146 18 and and CC cord-333986-xkx181ek 146 19 is be VBZ cord-333986-xkx181ek 146 20 likely likely JJ cord-333986-xkx181ek 146 21 to to TO cord-333986-xkx181ek 146 22 help help VB cord-333986-xkx181ek 146 23 to to IN cord-333986-xkx181ek 146 24 down down RB cord-333986-xkx181ek 146 25 - - HYPH cord-333986-xkx181ek 146 26 regulate regulate VB cord-333986-xkx181ek 146 27 neuroinflammation neuroinflammation NN cord-333986-xkx181ek 146 28 [ [ -LRB- cord-333986-xkx181ek 146 29 12 12 CD cord-333986-xkx181ek 146 30 , , , cord-333986-xkx181ek 146 31 72 72 CD cord-333986-xkx181ek 146 32 , , , cord-333986-xkx181ek 146 33 78 78 CD cord-333986-xkx181ek 146 34 , , , cord-333986-xkx181ek 146 35 [ [ -LRB- cord-333986-xkx181ek 146 36 80 80 CD cord-333986-xkx181ek 146 37 ] ] -RRB- cord-333986-xkx181ek 147 1 [ [ -LRB- cord-333986-xkx181ek 147 2 81 81 CD cord-333986-xkx181ek 147 3 ] ] -RRB- cord-333986-xkx181ek 148 1 [ [ -LRB- cord-333986-xkx181ek 148 2 82 82 CD cord-333986-xkx181ek 148 3 ] ] -RRB- cord-333986-xkx181ek 149 1 [ [ -LRB- cord-333986-xkx181ek 149 2 83 83 CD cord-333986-xkx181ek 149 3 ] ] -RRB- cord-333986-xkx181ek 150 1 [ [ -LRB- cord-333986-xkx181ek 150 2 84 84 CD cord-333986-xkx181ek 150 3 ] ] -RRB- cord-333986-xkx181ek 150 4 [ [ -LRB- cord-333986-xkx181ek 150 5 85 85 CD cord-333986-xkx181ek 150 6 ] ] -RRB- cord-333986-xkx181ek 150 7 [ [ -LRB- cord-333986-xkx181ek 150 8 86 86 CD cord-333986-xkx181ek 150 9 ] ] -RRB- cord-333986-xkx181ek 150 10 [ [ -LRB- cord-333986-xkx181ek 150 11 87 87 CD cord-333986-xkx181ek 150 12 ] ] -RRB- cord-333986-xkx181ek 151 1 [ [ -LRB- cord-333986-xkx181ek 151 2 88 88 CD cord-333986-xkx181ek 151 3 ] ] -RRB- cord-333986-xkx181ek 152 1 [ [ -LRB- cord-333986-xkx181ek 152 2 89 89 CD cord-333986-xkx181ek 152 3 ] ] -RRB- cord-333986-xkx181ek 152 4 [ [ -LRB- cord-333986-xkx181ek 152 5 90 90 CD cord-333986-xkx181ek 152 6 ] ] -RRB- cord-333986-xkx181ek 152 7 [ [ -LRB- cord-333986-xkx181ek 152 8 91 91 CD cord-333986-xkx181ek 152 9 ] ] -RRB- cord-333986-xkx181ek 152 10 . . . cord-333986-xkx181ek 153 1 Going go VBG cord-333986-xkx181ek 153 2 from from IN cord-333986-xkx181ek 153 3 moderate moderate JJ cord-333986-xkx181ek 153 4 - - HYPH cord-333986-xkx181ek 153 5 to to IN cord-333986-xkx181ek 153 6 high high JJ cord-333986-xkx181ek 153 7 - - HYPH cord-333986-xkx181ek 153 8 intensity intensity NN cord-333986-xkx181ek 153 9 exercise exercise NN cord-333986-xkx181ek 153 10 ( ( -LRB- cord-333986-xkx181ek 153 11 in in IN cord-333986-xkx181ek 153 12 animal animal NN cord-333986-xkx181ek 153 13 models model NNS cord-333986-xkx181ek 153 14 ) ) -RRB- cord-333986-xkx181ek 153 15 further further RB cord-333986-xkx181ek 153 16 reduces reduce VBZ cord-333986-xkx181ek 153 17 neuroinflammation neuroinflammation NN cord-333986-xkx181ek 153 18 , , , cord-333986-xkx181ek 153 19 which which WDT cord-333986-xkx181ek 153 20 implies imply VBZ cord-333986-xkx181ek 153 21 neuroprotection neuroprotection NN cord-333986-xkx181ek 153 22 [ [ -LRB- cord-333986-xkx181ek 153 23 73 73 CD cord-333986-xkx181ek 153 24 , , , cord-333986-xkx181ek 153 25 77 77 CD cord-333986-xkx181ek 153 26 ] ] -RRB- cord-333986-xkx181ek 153 27 . . . cord-333986-xkx181ek 154 1 O'Callaghan O'Callaghan NNP cord-333986-xkx181ek 154 2 et et NNP cord-333986-xkx181ek 154 3 al al NNP cord-333986-xkx181ek 154 4 . . NNP cord-333986-xkx181ek 154 5 showed show VBD cord-333986-xkx181ek 154 6 that that IN cord-333986-xkx181ek 154 7 high high JJ cord-333986-xkx181ek 154 8 - - HYPH cord-333986-xkx181ek 154 9 intensity intensity NN cord-333986-xkx181ek 154 10 interval interval NN cord-333986-xkx181ek 154 11 training training NN cord-333986-xkx181ek 154 12 ( ( -LRB- cord-333986-xkx181ek 154 13 HIIT HIIT NNP cord-333986-xkx181ek 154 14 ) ) -RRB- cord-333986-xkx181ek 154 15 exercise exercise VBP cord-333986-xkx181ek 154 16 significantly significantly RB cord-333986-xkx181ek 154 17 increased increase VBD cord-333986-xkx181ek 154 18 the the DT cord-333986-xkx181ek 154 19 neuroprotective neuroprotective JJ cord-333986-xkx181ek 154 20 substance substance NN cord-333986-xkx181ek 154 21 brain brain NN cord-333986-xkx181ek 154 22 - - HYPH cord-333986-xkx181ek 154 23 derived derive VBN cord-333986-xkx181ek 154 24 neurotrophic neurotrophic NN cord-333986-xkx181ek 154 25 factor factor NN cord-333986-xkx181ek 154 26 ( ( -LRB- cord-333986-xkx181ek 154 27 BDNF BDNF NNP cord-333986-xkx181ek 154 28 ) ) -RRB- cord-333986-xkx181ek 154 29 compared compare VBN cord-333986-xkx181ek 154 30 to to IN cord-333986-xkx181ek 154 31 both both DT cord-333986-xkx181ek 154 32 moderate moderate JJ cord-333986-xkx181ek 154 33 - - HYPH cord-333986-xkx181ek 154 34 intensity intensity NN cord-333986-xkx181ek 154 35 exercise exercise NN cord-333986-xkx181ek 154 36 and and CC cord-333986-xkx181ek 154 37 controls control VBZ cord-333986-xkx181ek 154 38 [ [ -LRB- cord-333986-xkx181ek 154 39 92 92 CD cord-333986-xkx181ek 154 40 ] ] -RRB- cord-333986-xkx181ek 154 41 . . . cord-333986-xkx181ek 155 1 Some some DT cord-333986-xkx181ek 155 2 of of IN cord-333986-xkx181ek 155 3 the the DT cord-333986-xkx181ek 155 4 issues issue NNS cord-333986-xkx181ek 155 5 addressed address VBN cord-333986-xkx181ek 155 6 in in IN cord-333986-xkx181ek 155 7 PwP pwp JJ cord-333986-xkx181ek 155 8 studies study NNS cord-333986-xkx181ek 155 9 revolve revolve VBP cord-333986-xkx181ek 155 10 around around IN cord-333986-xkx181ek 155 11 improving improve VBG cord-333986-xkx181ek 155 12 QoL qol NN cord-333986-xkx181ek 155 13 , , , cord-333986-xkx181ek 155 14 motor motor NN cord-333986-xkx181ek 155 15 vs. vs. FW cord-333986-xkx181ek 155 16 nonmotor nonmotor NN cord-333986-xkx181ek 155 17 skills skill NNS cord-333986-xkx181ek 155 18 , , , cord-333986-xkx181ek 155 19 and and CC cord-333986-xkx181ek 155 20 measured measure VBN cord-333986-xkx181ek 155 21 changes change NNS cord-333986-xkx181ek 155 22 in in IN cord-333986-xkx181ek 155 23 gait gait NN cord-333986-xkx181ek 155 24 , , , cord-333986-xkx181ek 155 25 balance balance NN cord-333986-xkx181ek 155 26 , , , cord-333986-xkx181ek 155 27 stiffness stiffness NN cord-333986-xkx181ek 155 28 , , , cord-333986-xkx181ek 155 29 axial axial JJ cord-333986-xkx181ek 155 30 mobility mobility NN cord-333986-xkx181ek 155 31 , , , cord-333986-xkx181ek 155 32 and and CC cord-333986-xkx181ek 155 33 cognitive cognitive JJ cord-333986-xkx181ek 155 34 improvements improvement NNS cord-333986-xkx181ek 155 35 . . . cord-333986-xkx181ek 156 1 The the DT cord-333986-xkx181ek 156 2 majority majority NN cord-333986-xkx181ek 156 3 of of IN cord-333986-xkx181ek 156 4 PwP PwP NNP cord-333986-xkx181ek 156 5 studies study NNS cord-333986-xkx181ek 156 6 suggest suggest VBP cord-333986-xkx181ek 156 7 that that IN cord-333986-xkx181ek 156 8 sustained sustain VBN cord-333986-xkx181ek 156 9 moderate moderate JJ cord-333986-xkx181ek 156 10 - - HYPH cord-333986-xkx181ek 156 11 intensity intensity NN cord-333986-xkx181ek 156 12 exercise exercise NN cord-333986-xkx181ek 156 13 will will MD cord-333986-xkx181ek 156 14 ultimately ultimately RB cord-333986-xkx181ek 156 15 improve improve VB cord-333986-xkx181ek 156 16 QoL qol NN cord-333986-xkx181ek 156 17 in in IN cord-333986-xkx181ek 156 18 PD PD NNP cord-333986-xkx181ek 156 19 and and CC cord-333986-xkx181ek 156 20 likely likely RB cord-333986-xkx181ek 156 21 reduce reduce VB cord-333986-xkx181ek 156 22 neuroinflammation neuroinflammation NN cord-333986-xkx181ek 156 23 . . . cord-333986-xkx181ek 157 1 Hopefully hopefully RB cord-333986-xkx181ek 157 2 , , , cord-333986-xkx181ek 157 3 future future JJ cord-333986-xkx181ek 157 4 studies study NNS cord-333986-xkx181ek 157 5 will will MD cord-333986-xkx181ek 157 6 continue continue VB cord-333986-xkx181ek 157 7 to to TO cord-333986-xkx181ek 157 8 differentiate differentiate VB cord-333986-xkx181ek 157 9 moderate moderate JJ cord-333986-xkx181ek 157 10 - - HYPH cord-333986-xkx181ek 157 11 vs vs NN cord-333986-xkx181ek 157 12 . . . cord-333986-xkx181ek 158 1 high high JJ cord-333986-xkx181ek 158 2 - - HYPH cord-333986-xkx181ek 158 3 intensity intensity NN cord-333986-xkx181ek 158 4 exercise exercise NN cord-333986-xkx181ek 158 5 in in IN cord-333986-xkx181ek 158 6 regard regard NN cord-333986-xkx181ek 158 7 to to IN cord-333986-xkx181ek 158 8 impact impact NN cord-333986-xkx181ek 158 9 on on IN cord-333986-xkx181ek 158 10 neuroinflammation neuroinflammation NN cord-333986-xkx181ek 158 11 and and CC cord-333986-xkx181ek 158 12 QoL. QoL. NNP cord-333986-xkx181ek 159 1 Neuroplasticity neuroplasticity NN cord-333986-xkx181ek 159 2 is be VBZ cord-333986-xkx181ek 159 3 the the DT cord-333986-xkx181ek 159 4 capacity capacity NN cord-333986-xkx181ek 159 5 of of IN cord-333986-xkx181ek 159 6 brain brain NN cord-333986-xkx181ek 159 7 cells cell NNS cord-333986-xkx181ek 159 8 to to TO cord-333986-xkx181ek 159 9 adapt adapt VB cord-333986-xkx181ek 159 10 , , , cord-333986-xkx181ek 159 11 change change VB cord-333986-xkx181ek 159 12 , , , cord-333986-xkx181ek 159 13 and and CC cord-333986-xkx181ek 159 14 form form VB cord-333986-xkx181ek 159 15 new new JJ cord-333986-xkx181ek 159 16 connections connection NNS cord-333986-xkx181ek 159 17 in in IN cord-333986-xkx181ek 159 18 response response NN cord-333986-xkx181ek 159 19 to to IN cord-333986-xkx181ek 159 20 intrinsic intrinsic JJ cord-333986-xkx181ek 159 21 and and CC cord-333986-xkx181ek 159 22 extrinsic extrinsic JJ cord-333986-xkx181ek 159 23 factors factor NNS cord-333986-xkx181ek 159 24 . . . cord-333986-xkx181ek 160 1 Despite despite IN cord-333986-xkx181ek 160 2 age age NN cord-333986-xkx181ek 160 3 - - HYPH cord-333986-xkx181ek 160 4 related relate VBN cord-333986-xkx181ek 160 5 changes change NNS cord-333986-xkx181ek 160 6 in in IN cord-333986-xkx181ek 160 7 cognitive cognitive JJ cord-333986-xkx181ek 160 8 function function NN cord-333986-xkx181ek 160 9 and and CC cord-333986-xkx181ek 160 10 brain brain NN cord-333986-xkx181ek 160 11 structure structure NN cord-333986-xkx181ek 160 12 with with IN cord-333986-xkx181ek 160 13 aging age VBG cord-333986-xkx181ek 160 14 , , , cord-333986-xkx181ek 160 15 functional functional JJ cord-333986-xkx181ek 160 16 neuroimaging neuroimaging NN cord-333986-xkx181ek 160 17 studies study NNS cord-333986-xkx181ek 160 18 have have VBP cord-333986-xkx181ek 160 19 shown show VBN cord-333986-xkx181ek 160 20 that that IN cord-333986-xkx181ek 160 21 the the DT cord-333986-xkx181ek 160 22 brain brain NN cord-333986-xkx181ek 160 23 maintains maintain VBZ cord-333986-xkx181ek 160 24 the the DT cord-333986-xkx181ek 160 25 ability ability NN cord-333986-xkx181ek 160 26 to to TO cord-333986-xkx181ek 160 27 increase increase VB cord-333986-xkx181ek 160 28 its -PRON- PRP$ cord-333986-xkx181ek 160 29 breadth breadth NN cord-333986-xkx181ek 160 30 of of IN cord-333986-xkx181ek 160 31 functioning function VBG cord-333986-xkx181ek 160 32 with with IN cord-333986-xkx181ek 160 33 age age NN cord-333986-xkx181ek 160 34 [ [ -LRB- cord-333986-xkx181ek 160 35 11 11 CD cord-333986-xkx181ek 160 36 , , , cord-333986-xkx181ek 160 37 93 93 CD cord-333986-xkx181ek 160 38 , , , cord-333986-xkx181ek 160 39 94 94 CD cord-333986-xkx181ek 160 40 ] ] -RRB- cord-333986-xkx181ek 160 41 . . . cord-333986-xkx181ek 161 1 Regular regular JJ cord-333986-xkx181ek 161 2 exercise exercise NN cord-333986-xkx181ek 161 3 is be VBZ cord-333986-xkx181ek 161 4 associated associate VBN cord-333986-xkx181ek 161 5 with with IN cord-333986-xkx181ek 161 6 the the DT cord-333986-xkx181ek 161 7 release release NN cord-333986-xkx181ek 161 8 of of IN cord-333986-xkx181ek 161 9 endogenous endogenous JJ cord-333986-xkx181ek 161 10 neurotrophins neurotrophin NNS cord-333986-xkx181ek 161 11 , , , cord-333986-xkx181ek 161 12 such such JJ cord-333986-xkx181ek 161 13 as as IN cord-333986-xkx181ek 161 14 glia glia NN cord-333986-xkx181ek 161 15 - - HYPH cord-333986-xkx181ek 161 16 derived derive VBN cord-333986-xkx181ek 161 17 neurotrophin neurotrophin NN cord-333986-xkx181ek 161 18 ( ( -LRB- cord-333986-xkx181ek 161 19 GDNF GDNF NNP cord-333986-xkx181ek 161 20 ) ) -RRB- cord-333986-xkx181ek 161 21 that that WDT cord-333986-xkx181ek 161 22 are be VBP cord-333986-xkx181ek 161 23 related relate VBN cord-333986-xkx181ek 161 24 to to IN cord-333986-xkx181ek 161 25 synaptic synaptic JJ cord-333986-xkx181ek 161 26 plasticity plasticity NN cord-333986-xkx181ek 161 27 , , , cord-333986-xkx181ek 161 28 enhanced enhance VBN cord-333986-xkx181ek 161 29 cognitive cognitive JJ cord-333986-xkx181ek 161 30 ability ability NN cord-333986-xkx181ek 161 31 , , , cord-333986-xkx181ek 161 32 learning learning NN cord-333986-xkx181ek 161 33 , , , cord-333986-xkx181ek 161 34 and and CC cord-333986-xkx181ek 161 35 memory memory NN cord-333986-xkx181ek 161 36 [ [ -LRB- cord-333986-xkx181ek 161 37 12 12 CD cord-333986-xkx181ek 161 38 ] ] -RRB- cord-333986-xkx181ek 161 39 . . . cord-333986-xkx181ek 162 1 Most Most JJS cord-333986-xkx181ek 162 2 evidence evidence NN cord-333986-xkx181ek 162 3 of of IN cord-333986-xkx181ek 162 4 exercise exercise NN cord-333986-xkx181ek 162 5 - - HYPH cord-333986-xkx181ek 162 6 induced induce VBN cord-333986-xkx181ek 162 7 neuroplasticity neuroplasticity NN cord-333986-xkx181ek 162 8 is be VBZ cord-333986-xkx181ek 162 9 derived derive VBN cord-333986-xkx181ek 162 10 from from IN cord-333986-xkx181ek 162 11 studies study NNS cord-333986-xkx181ek 162 12 involving involve VBG cord-333986-xkx181ek 162 13 animal animal NN cord-333986-xkx181ek 162 14 models model NNS cord-333986-xkx181ek 162 15 exposed expose VBN cord-333986-xkx181ek 162 16 to to IN cord-333986-xkx181ek 162 17 forced force VBN cord-333986-xkx181ek 162 18 use use NN cord-333986-xkx181ek 162 19 , , , cord-333986-xkx181ek 162 20 task task NN cord-333986-xkx181ek 162 21 - - HYPH cord-333986-xkx181ek 162 22 specific specific JJ cord-333986-xkx181ek 162 23 , , , cord-333986-xkx181ek 162 24 and and CC cord-333986-xkx181ek 162 25 high high JJ cord-333986-xkx181ek 162 26 - - HYPH cord-333986-xkx181ek 162 27 intensity intensity NN cord-333986-xkx181ek 162 28 exercise exercise NN cord-333986-xkx181ek 162 29 . . . cord-333986-xkx181ek 163 1 Tillerson Tillerson NNP cord-333986-xkx181ek 163 2 et et NNP cord-333986-xkx181ek 163 3 al al NNP cord-333986-xkx181ek 163 4 . . . cord-333986-xkx181ek 164 1 found find VBD cord-333986-xkx181ek 164 2 that that IN cord-333986-xkx181ek 164 3 in in IN cord-333986-xkx181ek 164 4 rats rat NNS cord-333986-xkx181ek 164 5 with with IN cord-333986-xkx181ek 164 6 unilateral unilateral JJ cord-333986-xkx181ek 164 7 dopamine dopamine NN cord-333986-xkx181ek 164 8 depletion depletion NN cord-333986-xkx181ek 164 9 , , , cord-333986-xkx181ek 164 10 forced force VBN cord-333986-xkx181ek 164 11 use use NN cord-333986-xkx181ek 164 12 of of IN cord-333986-xkx181ek 164 13 the the DT cord-333986-xkx181ek 164 14 impaired impair VBN cord-333986-xkx181ek 164 15 forelimb forelimb NN cord-333986-xkx181ek 164 16 spared spare VBD cord-333986-xkx181ek 164 17 asymmetrical asymmetrical JJ cord-333986-xkx181ek 164 18 motor motor NN cord-333986-xkx181ek 164 19 impairment impairment NN cord-333986-xkx181ek 164 20 and and CC cord-333986-xkx181ek 164 21 decreased decrease VBD cord-333986-xkx181ek 164 22 the the DT cord-333986-xkx181ek 164 23 extent extent NN cord-333986-xkx181ek 164 24 of of IN cord-333986-xkx181ek 164 25 dopamine dopamine NN cord-333986-xkx181ek 164 26 neuronal neuronal JJ cord-333986-xkx181ek 164 27 degeneration degeneration NN cord-333986-xkx181ek 164 28 [ [ -LRB- cord-333986-xkx181ek 164 29 95 95 CD cord-333986-xkx181ek 164 30 ] ] -RRB- cord-333986-xkx181ek 164 31 . . . cord-333986-xkx181ek 165 1 Cohen Cohen NNP cord-333986-xkx181ek 165 2 et et NNP cord-333986-xkx181ek 165 3 al al NNP cord-333986-xkx181ek 165 4 . . NNP cord-333986-xkx181ek 165 5 completed complete VBD cord-333986-xkx181ek 165 6 a a DT cord-333986-xkx181ek 165 7 follow follow NN cord-333986-xkx181ek 165 8 - - HYPH cord-333986-xkx181ek 165 9 up up NN cord-333986-xkx181ek 165 10 to to IN cord-333986-xkx181ek 165 11 this this DT cord-333986-xkx181ek 165 12 study study NN cord-333986-xkx181ek 165 13 [ [ -LRB- cord-333986-xkx181ek 165 14 96 96 CD cord-333986-xkx181ek 165 15 ] ] -RRB- cord-333986-xkx181ek 165 16 . . . cord-333986-xkx181ek 166 1 They -PRON- PRP cord-333986-xkx181ek 166 2 found find VBD cord-333986-xkx181ek 166 3 that that IN cord-333986-xkx181ek 166 4 in in IN cord-333986-xkx181ek 166 5 the the DT cord-333986-xkx181ek 166 6 forced force VBN cord-333986-xkx181ek 166 7 use use NN cord-333986-xkx181ek 166 8 limb limb NN cord-333986-xkx181ek 166 9 , , , cord-333986-xkx181ek 166 10 in in IN cord-333986-xkx181ek 166 11 addition addition NN cord-333986-xkx181ek 166 12 to to IN cord-333986-xkx181ek 166 13 spared spare VBN cord-333986-xkx181ek 166 14 asymmetrical asymmetrical JJ cord-333986-xkx181ek 166 15 motor motor NN cord-333986-xkx181ek 166 16 impairment impairment NN cord-333986-xkx181ek 166 17 , , , cord-333986-xkx181ek 166 18 there there EX cord-333986-xkx181ek 166 19 is be VBZ cord-333986-xkx181ek 166 20 an an DT cord-333986-xkx181ek 166 21 increase increase NN cord-333986-xkx181ek 166 22 in in IN cord-333986-xkx181ek 166 23 GDNF GDNF NNP cord-333986-xkx181ek 166 24 in in IN cord-333986-xkx181ek 166 25 the the DT cord-333986-xkx181ek 166 26 striatum striatum NN cord-333986-xkx181ek 166 27 in in IN cord-333986-xkx181ek 166 28 response response NN cord-333986-xkx181ek 166 29 to to IN cord-333986-xkx181ek 166 30 forced force VBN cord-333986-xkx181ek 166 31 exercise exercise NN cord-333986-xkx181ek 166 32 [ [ -LRB- cord-333986-xkx181ek 166 33 96 96 CD cord-333986-xkx181ek 166 34 ] ] -RRB- cord-333986-xkx181ek 166 35 . . . cord-333986-xkx181ek 167 1 Several several JJ cord-333986-xkx181ek 167 2 other other JJ cord-333986-xkx181ek 167 3 studies study NNS cord-333986-xkx181ek 167 4 replicated replicate VBD cord-333986-xkx181ek 167 5 these these DT cord-333986-xkx181ek 167 6 data datum NNS cord-333986-xkx181ek 167 7 using use VBG cord-333986-xkx181ek 167 8 different different JJ cord-333986-xkx181ek 167 9 exercise exercise NN cord-333986-xkx181ek 167 10 paradigms paradigm NNS cord-333986-xkx181ek 167 11 such such JJ cord-333986-xkx181ek 167 12 as as IN cord-333986-xkx181ek 167 13 treadmill treadmill NN cord-333986-xkx181ek 167 14 exercise exercise NN cord-333986-xkx181ek 167 15 , , , cord-333986-xkx181ek 167 16 environmental environmental JJ cord-333986-xkx181ek 167 17 enrichment enrichment NN cord-333986-xkx181ek 167 18 , , , cord-333986-xkx181ek 167 19 and and CC cord-333986-xkx181ek 167 20 voluntary voluntary JJ cord-333986-xkx181ek 167 21 running running NN cord-333986-xkx181ek 167 22 . . . cord-333986-xkx181ek 168 1 Exceptions exception NNS cord-333986-xkx181ek 168 2 to to IN cord-333986-xkx181ek 168 3 these these DT cord-333986-xkx181ek 168 4 data datum NNS cord-333986-xkx181ek 168 5 replication replication NN cord-333986-xkx181ek 168 6 have have VBP cord-333986-xkx181ek 168 7 suggested suggest VBN cord-333986-xkx181ek 168 8 that that IN cord-333986-xkx181ek 168 9 the the DT cord-333986-xkx181ek 168 10 type type NN cord-333986-xkx181ek 168 11 of of IN cord-333986-xkx181ek 168 12 motor motor NN cord-333986-xkx181ek 168 13 training training NN cord-333986-xkx181ek 168 14 ( ( -LRB- cord-333986-xkx181ek 168 15 skilled skilled JJ cord-333986-xkx181ek 168 16 vs. vs. FW cord-333986-xkx181ek 168 17 aerobic aerobic JJ cord-333986-xkx181ek 168 18 ) ) -RRB- cord-333986-xkx181ek 168 19 affects affect VBZ cord-333986-xkx181ek 168 20 the the DT cord-333986-xkx181ek 168 21 degree degree NN cord-333986-xkx181ek 168 22 of of IN cord-333986-xkx181ek 168 23 protection protection NN cord-333986-xkx181ek 168 24 PD PD NNP cord-333986-xkx181ek 168 25 [ [ -LRB- cord-333986-xkx181ek 168 26 12 12 CD cord-333986-xkx181ek 168 27 ] ] -RRB- cord-333986-xkx181ek 168 28 . . . cord-333986-xkx181ek 169 1 Steiner Steiner NNP cord-333986-xkx181ek 169 2 et et NNP cord-333986-xkx181ek 169 3 al al NNP cord-333986-xkx181ek 169 4 . . . cord-333986-xkx181ek 170 1 [ [ -LRB- cord-333986-xkx181ek 170 2 97 97 CD cord-333986-xkx181ek 170 3 ] ] -RRB- cord-333986-xkx181ek 170 4 found find VBD cord-333986-xkx181ek 170 5 that that IN cord-333986-xkx181ek 170 6 PD PD NNP cord-333986-xkx181ek 170 7 model model NN cord-333986-xkx181ek 170 8 rats rat NNS cord-333986-xkx181ek 170 9 living live VBG cord-333986-xkx181ek 170 10 in in IN cord-333986-xkx181ek 170 11 an an DT cord-333986-xkx181ek 170 12 enriched enriched JJ cord-333986-xkx181ek 170 13 environment environment NN cord-333986-xkx181ek 170 14 with with IN cord-333986-xkx181ek 170 15 physical physical JJ cord-333986-xkx181ek 170 16 activity activity NN cord-333986-xkx181ek 170 17 for for IN cord-333986-xkx181ek 170 18 seven seven CD cord-333986-xkx181ek 170 19 weeks week NNS cord-333986-xkx181ek 170 20 showed show VBD cord-333986-xkx181ek 170 21 a a DT cord-333986-xkx181ek 170 22 significant significant JJ cord-333986-xkx181ek 170 23 increase increase NN cord-333986-xkx181ek 170 24 in in IN cord-333986-xkx181ek 170 25 the the DT cord-333986-xkx181ek 170 26 number number NN cord-333986-xkx181ek 170 27 of of IN cord-333986-xkx181ek 170 28 NG2-positive ng2-positive NN cord-333986-xkx181ek 170 29 and and CC cord-333986-xkx181ek 170 30 GFAP GFAP NNP cord-333986-xkx181ek 170 31 - - HYPH cord-333986-xkx181ek 170 32 positive positive JJ cord-333986-xkx181ek 170 33 cells cell NNS cord-333986-xkx181ek 170 34 in in IN cord-333986-xkx181ek 170 35 the the DT cord-333986-xkx181ek 170 36 substantia substantia NN cord-333986-xkx181ek 170 37 nigra nigra NN cord-333986-xkx181ek 170 38 of of IN cord-333986-xkx181ek 170 39 the the DT cord-333986-xkx181ek 170 40 basal basal NN cord-333986-xkx181ek 170 41 ganglia ganglion NNS cord-333986-xkx181ek 170 42 , , , cord-333986-xkx181ek 170 43 suggesting suggest VBG cord-333986-xkx181ek 170 44 significant significant JJ cord-333986-xkx181ek 170 45 gliosis gliosis NN cord-333986-xkx181ek 170 46 in in IN cord-333986-xkx181ek 170 47 response response NN cord-333986-xkx181ek 170 48 to to TO cord-333986-xkx181ek 170 49 exercise exercise VB cord-333986-xkx181ek 170 50 . . . cord-333986-xkx181ek 171 1 In in IN cord-333986-xkx181ek 171 2 response response NN cord-333986-xkx181ek 171 3 to to IN cord-333986-xkx181ek 171 4 significant significant JJ cord-333986-xkx181ek 171 5 neuroprotective neuroprotective JJ cord-333986-xkx181ek 171 6 evidence evidence NN cord-333986-xkx181ek 171 7 in in IN cord-333986-xkx181ek 171 8 animal animal NN cord-333986-xkx181ek 171 9 models model NNS cord-333986-xkx181ek 171 10 , , , cord-333986-xkx181ek 171 11 Farley Farley NNP cord-333986-xkx181ek 171 12 et et NNP cord-333986-xkx181ek 171 13 al al NNP cord-333986-xkx181ek 171 14 . . NNP cord-333986-xkx181ek 171 15 introduced introduce VBD cord-333986-xkx181ek 171 16 the the DT cord-333986-xkx181ek 171 17 principle principle NN cord-333986-xkx181ek 171 18 of of IN cord-333986-xkx181ek 171 19 intensive intensive JJ cord-333986-xkx181ek 171 20 amplitude amplitude NN cord-333986-xkx181ek 171 21 - - HYPH cord-333986-xkx181ek 171 22 specific specific JJ cord-333986-xkx181ek 171 23 exercise exercise NN cord-333986-xkx181ek 171 24 - - HYPH cord-333986-xkx181ek 171 25 based base VBN cord-333986-xkx181ek 171 26 therapeutic therapeutic JJ cord-333986-xkx181ek 171 27 approaches approach NNS cord-333986-xkx181ek 171 28 for for IN cord-333986-xkx181ek 171 29 humans human NNS cord-333986-xkx181ek 171 30 [ [ -LRB- cord-333986-xkx181ek 171 31 12 12 CD cord-333986-xkx181ek 171 32 , , , cord-333986-xkx181ek 171 33 80 80 CD cord-333986-xkx181ek 171 34 , , , cord-333986-xkx181ek 171 35 98 98 CD cord-333986-xkx181ek 171 36 ] ] -RRB- cord-333986-xkx181ek 171 37 . . . cord-333986-xkx181ek 172 1 This this DT cord-333986-xkx181ek 172 2 innovative innovative JJ cord-333986-xkx181ek 172 3 exercise exercise NN cord-333986-xkx181ek 172 4 program program NN cord-333986-xkx181ek 172 5 named name VBN cord-333986-xkx181ek 172 6 LSVT LSVT NNP cord-333986-xkx181ek 172 7 / / SYM cord-333986-xkx181ek 172 8 BIG BIG NNP cord-333986-xkx181ek 172 9 was be VBD cord-333986-xkx181ek 172 10 focused focus VBN cord-333986-xkx181ek 172 11 on on IN cord-333986-xkx181ek 172 12 improving improve VBG cord-333986-xkx181ek 172 13 disease disease NN cord-333986-xkx181ek 172 14 outcomes outcome NNS cord-333986-xkx181ek 172 15 in in IN cord-333986-xkx181ek 172 16 PwP. PwP. NNP cord-333986-xkx181ek 173 1 The the DT cord-333986-xkx181ek 173 2 loss loss NN cord-333986-xkx181ek 173 3 of of IN cord-333986-xkx181ek 173 4 dopamine dopamine NN cord-333986-xkx181ek 173 5 in in IN cord-333986-xkx181ek 173 6 PD PD NNP cord-333986-xkx181ek 173 7 triggers trigger VBZ cord-333986-xkx181ek 173 8 faulty faulty JJ cord-333986-xkx181ek 173 9 processing processing NN cord-333986-xkx181ek 173 10 , , , cord-333986-xkx181ek 173 11 output output NN cord-333986-xkx181ek 173 12 , , , cord-333986-xkx181ek 173 13 and and CC cord-333986-xkx181ek 173 14 feedback feedback NN cord-333986-xkx181ek 173 15 within within IN cord-333986-xkx181ek 173 16 the the DT cord-333986-xkx181ek 173 17 basal basal NN cord-333986-xkx181ek 173 18 ganglia ganglion NNS cord-333986-xkx181ek 173 19 ( ( -LRB- cord-333986-xkx181ek 173 20 BG BG NNP cord-333986-xkx181ek 173 21 ) ) -RRB- cord-333986-xkx181ek 173 22 . . . cord-333986-xkx181ek 174 1 Their -PRON- PRP$ cord-333986-xkx181ek 174 2 hypothesis hypothesis NN cord-333986-xkx181ek 174 3 suggested suggest VBD cord-333986-xkx181ek 174 4 that that IN cord-333986-xkx181ek 174 5 instead instead RB cord-333986-xkx181ek 174 6 of of IN cord-333986-xkx181ek 174 7 bypassing bypass VBG cord-333986-xkx181ek 174 8 the the DT cord-333986-xkx181ek 174 9 BG bg NN cord-333986-xkx181ek 174 10 in in IN cord-333986-xkx181ek 174 11 treatment treatment NN cord-333986-xkx181ek 174 12 , , , cord-333986-xkx181ek 174 13 targeted target VBN cord-333986-xkx181ek 174 14 amplitude amplitude NN cord-333986-xkx181ek 174 15 exercise exercise NN cord-333986-xkx181ek 174 16 ( ( -LRB- cord-333986-xkx181ek 174 17 LSVT LSVT NNP cord-333986-xkx181ek 174 18 / / SYM cord-333986-xkx181ek 174 19 BIG BIG NNP cord-333986-xkx181ek 174 20 ) ) -RRB- cord-333986-xkx181ek 174 21 could could MD cord-333986-xkx181ek 174 22 be be VB cord-333986-xkx181ek 174 23 used use VBN cord-333986-xkx181ek 174 24 to to TO cord-333986-xkx181ek 174 25 harness harness VB cord-333986-xkx181ek 174 26 neuroplasticity neuroplasticity NN cord-333986-xkx181ek 174 27 to to TO cord-333986-xkx181ek 174 28 enhance enhance VB cord-333986-xkx181ek 174 29 activation activation NN cord-333986-xkx181ek 174 30 of of IN cord-333986-xkx181ek 174 31 damaged damage VBN cord-333986-xkx181ek 174 32 BG BG NNP cord-333986-xkx181ek 174 33 pathways pathway NNS cord-333986-xkx181ek 174 34 and and CC cord-333986-xkx181ek 174 35 potentially potentially RB cord-333986-xkx181ek 174 36 slow slow VB cord-333986-xkx181ek 174 37 their -PRON- PRP$ cord-333986-xkx181ek 174 38 degradation degradation NN cord-333986-xkx181ek 174 39 [ [ -LRB- cord-333986-xkx181ek 174 40 12 12 CD cord-333986-xkx181ek 174 41 , , , cord-333986-xkx181ek 174 42 80 80 CD cord-333986-xkx181ek 174 43 , , , cord-333986-xkx181ek 174 44 98 98 CD cord-333986-xkx181ek 174 45 ] ] -RRB- cord-333986-xkx181ek 174 46 . . . cord-333986-xkx181ek 175 1 An an DT cord-333986-xkx181ek 175 2 LSVT LSVT NNP cord-333986-xkx181ek 175 3 / / SYM cord-333986-xkx181ek 175 4 BIG big RB cord-333986-xkx181ek 175 5 - - HYPH cord-333986-xkx181ek 175 6 certified certify VBN cord-333986-xkx181ek 175 7 Neurologist Neurologist NNP cord-333986-xkx181ek 175 8 prescribes prescribe VBZ cord-333986-xkx181ek 175 9 LSVT LSVT NNP cord-333986-xkx181ek 175 10 / / SYM cord-333986-xkx181ek 175 11 BIG big JJ cord-333986-xkx181ek 175 12 to to IN cord-333986-xkx181ek 175 13 the the DT cord-333986-xkx181ek 175 14 PwP pwp NN cord-333986-xkx181ek 175 15 , , , cord-333986-xkx181ek 175 16 who who WP cord-333986-xkx181ek 175 17 then then RB cord-333986-xkx181ek 175 18 has have VBZ cord-333986-xkx181ek 175 19 specialized specialize VBN cord-333986-xkx181ek 175 20 training training NN cord-333986-xkx181ek 175 21 sessions session NNS cord-333986-xkx181ek 175 22 with with IN cord-333986-xkx181ek 175 23 an an DT cord-333986-xkx181ek 175 24 LSVT LSVT NNP cord-333986-xkx181ek 175 25 / / SYM cord-333986-xkx181ek 175 26 BIG big RB cord-333986-xkx181ek 175 27 - - HYPH cord-333986-xkx181ek 175 28 certified certify VBN cord-333986-xkx181ek 175 29 Physical Physical NNP cord-333986-xkx181ek 175 30 Therapist therapist NN cord-333986-xkx181ek 175 31 ( ( -LRB- cord-333986-xkx181ek 175 32 PT PT NNP cord-333986-xkx181ek 175 33 ) ) -RRB- cord-333986-xkx181ek 175 34 . . . cord-333986-xkx181ek 176 1 After after IN cord-333986-xkx181ek 176 2 completion completion NN cord-333986-xkx181ek 176 3 of of IN cord-333986-xkx181ek 176 4 the the DT cord-333986-xkx181ek 176 5 4 4 CD cord-333986-xkx181ek 176 6 weeks week NNS cord-333986-xkx181ek 176 7 ( ( -LRB- cord-333986-xkx181ek 176 8 4 4 CD cord-333986-xkx181ek 176 9 days day NNS cord-333986-xkx181ek 176 10 / / SYM cord-333986-xkx181ek 176 11 week week NN cord-333986-xkx181ek 176 12 ) ) -RRB- cord-333986-xkx181ek 176 13 of of IN cord-333986-xkx181ek 176 14 program program NN cord-333986-xkx181ek 176 15 training training NN cord-333986-xkx181ek 176 16 , , , cord-333986-xkx181ek 176 17 the the DT cord-333986-xkx181ek 176 18 PwP pwp NN cord-333986-xkx181ek 176 19 continues continue VBZ cord-333986-xkx181ek 176 20 the the DT cord-333986-xkx181ek 176 21 LSVT LSVT NNP cord-333986-xkx181ek 176 22 / / SYM cord-333986-xkx181ek 176 23 BIG big JJ cord-333986-xkx181ek 176 24 exercises exercise NNS cord-333986-xkx181ek 176 25 on on IN cord-333986-xkx181ek 176 26 their -PRON- PRP$ cord-333986-xkx181ek 176 27 own own JJ cord-333986-xkx181ek 176 28 to to TO cord-333986-xkx181ek 176 29 further further RB cord-333986-xkx181ek 176 30 address address VB cord-333986-xkx181ek 176 31 their -PRON- PRP$ cord-333986-xkx181ek 176 32 motor motor NN cord-333986-xkx181ek 176 33 - - HYPH cord-333986-xkx181ek 176 34 related relate VBN cord-333986-xkx181ek 176 35 problems problem NNS cord-333986-xkx181ek 176 36 . . . cord-333986-xkx181ek 177 1 The the DT cord-333986-xkx181ek 177 2 Berlin Berlin NNP cord-333986-xkx181ek 177 3 LSVT LSVT NNP cord-333986-xkx181ek 177 4 / / SYM cord-333986-xkx181ek 177 5 BIG BIG NNP cord-333986-xkx181ek 177 6 comparative comparative JJ cord-333986-xkx181ek 177 7 study study NN cord-333986-xkx181ek 177 8 randomly randomly RB cord-333986-xkx181ek 177 9 assigned assign VBD cord-333986-xkx181ek 177 10 mild mild JJ cord-333986-xkx181ek 177 11 to to IN cord-333986-xkx181ek 177 12 moderate moderate JJ cord-333986-xkx181ek 177 13 PD PD NNP cord-333986-xkx181ek 177 14 patients patient NNS cord-333986-xkx181ek 177 15 to to IN cord-333986-xkx181ek 177 16 either either CC cord-333986-xkx181ek 177 17 supervised supervise VBN cord-333986-xkx181ek 177 18 LSVT LSVT NNP cord-333986-xkx181ek 177 19 / / SYM cord-333986-xkx181ek 177 20 BIG big JJ cord-333986-xkx181ek 177 21 training training NN cord-333986-xkx181ek 177 22 ( ( -LRB- cord-333986-xkx181ek 177 23 BIG BIG NNP cord-333986-xkx181ek 177 24 ) ) -RRB- cord-333986-xkx181ek 177 25 , , , cord-333986-xkx181ek 177 26 supervised supervise VBN cord-333986-xkx181ek 177 27 Nordic Nordic NNP cord-333986-xkx181ek 177 28 Walking Walking NNP cord-333986-xkx181ek 177 29 ( ( -LRB- cord-333986-xkx181ek 177 30 WALK walk NN cord-333986-xkx181ek 177 31 ) ) -RRB- cord-333986-xkx181ek 177 32 , , , cord-333986-xkx181ek 177 33 or or CC cord-333986-xkx181ek 177 34 nonsupervised nonsupervised JJ cord-333986-xkx181ek 177 35 exercises exercise NNS cord-333986-xkx181ek 177 36 ( ( -LRB- cord-333986-xkx181ek 177 37 HOME home NN cord-333986-xkx181ek 177 38 ) ) -RRB- cord-333986-xkx181ek 177 39 [ [ -LRB- cord-333986-xkx181ek 177 40 99 99 CD cord-333986-xkx181ek 177 41 ] ] -RRB- cord-333986-xkx181ek 177 42 . . . cord-333986-xkx181ek 178 1 Following follow VBG cord-333986-xkx181ek 178 2 16 16 CD cord-333986-xkx181ek 178 3 weeks week NNS cord-333986-xkx181ek 178 4 of of IN cord-333986-xkx181ek 178 5 therapy therapy NN cord-333986-xkx181ek 178 6 and and CC cord-333986-xkx181ek 178 7 exercise exercise NN cord-333986-xkx181ek 178 8 , , , cord-333986-xkx181ek 178 9 there there EX cord-333986-xkx181ek 178 10 was be VBD cord-333986-xkx181ek 178 11 a a DT cord-333986-xkx181ek 178 12 5.05 5.05 CD cord-333986-xkx181ek 178 13 improvement improvement NN cord-333986-xkx181ek 178 14 in in IN cord-333986-xkx181ek 178 15 Unified Unified NNP cord-333986-xkx181ek 178 16 Parkinson Parkinson NNP cord-333986-xkx181ek 178 17 Disease Disease NNP cord-333986-xkx181ek 178 18 Rating Rating NNP cord-333986-xkx181ek 178 19 Scale Scale NNP cord-333986-xkx181ek 178 20 ( ( -LRB- cord-333986-xkx181ek 178 21 UPDRS UPDRS NNP cord-333986-xkx181ek 178 22 ) ) -RRB- cord-333986-xkx181ek 178 23 score score VB cord-333986-xkx181ek 178 24 in in IN cord-333986-xkx181ek 178 25 the the DT cord-333986-xkx181ek 178 26 BIG big JJ cord-333986-xkx181ek 178 27 group group NN cord-333986-xkx181ek 178 28 , , , cord-333986-xkx181ek 178 29 whereas whereas IN cord-333986-xkx181ek 178 30 there there EX cord-333986-xkx181ek 178 31 was be VBD cord-333986-xkx181ek 178 32 a a DT cord-333986-xkx181ek 178 33 0.58 0.58 CD cord-333986-xkx181ek 178 34 and and CC cord-333986-xkx181ek 178 35 1.68 1.68 CD cord-333986-xkx181ek 178 36 increase increase NN cord-333986-xkx181ek 178 37 , , , cord-333986-xkx181ek 178 38 respectively respectively RB cord-333986-xkx181ek 178 39 , , , cord-333986-xkx181ek 178 40 in in IN cord-333986-xkx181ek 178 41 UPDRS UPDRS NNP cord-333986-xkx181ek 178 42 scores score NNS cord-333986-xkx181ek 178 43 in in IN cord-333986-xkx181ek 178 44 the the DT cord-333986-xkx181ek 178 45 WALK walk NN cord-333986-xkx181ek 178 46 and and CC cord-333986-xkx181ek 178 47 HOME home NN cord-333986-xkx181ek 178 48 groups group NNS cord-333986-xkx181ek 178 49 [ [ -LRB- cord-333986-xkx181ek 178 50 99 99 CD cord-333986-xkx181ek 178 51 ] ] -RRB- cord-333986-xkx181ek 178 52 . . . cord-333986-xkx181ek 179 1 A a DT cord-333986-xkx181ek 179 2 retrospective retrospective JJ cord-333986-xkx181ek 179 3 study study NN cord-333986-xkx181ek 179 4 by by IN cord-333986-xkx181ek 179 5 Isaacson Isaacson NNP cord-333986-xkx181ek 179 6 et et NNP cord-333986-xkx181ek 179 7 al al NNP cord-333986-xkx181ek 179 8 . . . cord-333986-xkx181ek 180 1 of of IN cord-333986-xkx181ek 180 2 PwP PwP NNP cord-333986-xkx181ek 180 3 taking take VBG cord-333986-xkx181ek 180 4 part part NN cord-333986-xkx181ek 180 5 in in IN cord-333986-xkx181ek 180 6 the the DT cord-333986-xkx181ek 180 7 LSVT LSVT NNP cord-333986-xkx181ek 180 8 / / SYM cord-333986-xkx181ek 180 9 BIG BIG NNP cord-333986-xkx181ek 180 10 program program NN cord-333986-xkx181ek 180 11 found find VBD cord-333986-xkx181ek 180 12 significant significant JJ cord-333986-xkx181ek 180 13 improvements improvement NNS cord-333986-xkx181ek 180 14 in in IN cord-333986-xkx181ek 180 15 dual dual RB cord-333986-xkx181ek 180 16 - - HYPH cord-333986-xkx181ek 180 17 tasked task VBN cord-333986-xkx181ek 180 18 tests test NNS cord-333986-xkx181ek 180 19 ( ( -LRB- cord-333986-xkx181ek 180 20 specifically specifically RB cord-333986-xkx181ek 180 21 measuring measure VBG cord-333986-xkx181ek 180 22 mobility mobility NN cord-333986-xkx181ek 180 23 and and CC cord-333986-xkx181ek 180 24 cognitive cognitive JJ cord-333986-xkx181ek 180 25 performance performance NN cord-333986-xkx181ek 180 26 while while IN cord-333986-xkx181ek 180 27 performing perform VBG cord-333986-xkx181ek 180 28 two two CD cord-333986-xkx181ek 180 29 tasks task NNS cord-333986-xkx181ek 180 30 simultaneously simultaneously RB cord-333986-xkx181ek 180 31 ) ) -RRB- cord-333986-xkx181ek 180 32 [ [ -LRB- cord-333986-xkx181ek 180 33 100 100 CD cord-333986-xkx181ek 180 34 ] ] -RRB- cord-333986-xkx181ek 180 35 . . . cord-333986-xkx181ek 181 1 These these DT cord-333986-xkx181ek 181 2 studies study NNS cord-333986-xkx181ek 181 3 with with IN cord-333986-xkx181ek 181 4 LSVT LSVT NNP cord-333986-xkx181ek 181 5 / / SYM cord-333986-xkx181ek 181 6 BIG BIG NNP cord-333986-xkx181ek 181 7 suggest suggest VBP cord-333986-xkx181ek 181 8 that that IN cord-333986-xkx181ek 181 9 intensive intensive JJ cord-333986-xkx181ek 181 10 amplitude amplitude NN cord-333986-xkx181ek 181 11 - - HYPH cord-333986-xkx181ek 181 12 directed direct VBN cord-333986-xkx181ek 181 13 exercise exercise NN cord-333986-xkx181ek 181 14 programs program NNS cord-333986-xkx181ek 181 15 , , , cord-333986-xkx181ek 181 16 when when WRB cord-333986-xkx181ek 181 17 directed direct VBN cord-333986-xkx181ek 181 18 by by IN cord-333986-xkx181ek 181 19 a a DT cord-333986-xkx181ek 181 20 knowledgeable knowledgeable JJ cord-333986-xkx181ek 181 21 PT pt NN cord-333986-xkx181ek 181 22 , , , cord-333986-xkx181ek 181 23 are be VBP cord-333986-xkx181ek 181 24 capable capable JJ cord-333986-xkx181ek 181 25 of of IN cord-333986-xkx181ek 181 26 achieving achieve VBG cord-333986-xkx181ek 181 27 activity activity NN cord-333986-xkx181ek 181 28 - - HYPH cord-333986-xkx181ek 181 29 dependent dependent JJ cord-333986-xkx181ek 181 30 neuroplasticity neuroplasticity NN cord-333986-xkx181ek 181 31 and and CC cord-333986-xkx181ek 181 32 motor motor NN cord-333986-xkx181ek 181 33 learning learn VBG cord-333986-xkx181ek 181 34 in in IN cord-333986-xkx181ek 181 35 PwP. PwP. NNP cord-333986-xkx181ek 181 36 Schenkman Schenkman NNP cord-333986-xkx181ek 181 37 et et FW cord-333986-xkx181ek 181 38 al al NNP cord-333986-xkx181ek 181 39 . . . cord-333986-xkx181ek 182 1 found find VBD cord-333986-xkx181ek 182 2 that that IN cord-333986-xkx181ek 182 3 changes change NNS cord-333986-xkx181ek 182 4 in in IN cord-333986-xkx181ek 182 5 motor motor NN cord-333986-xkx181ek 182 6 symptoms symptom NNS cord-333986-xkx181ek 182 7 , , , cord-333986-xkx181ek 182 8 measured measure VBN cord-333986-xkx181ek 182 9 with with IN cord-333986-xkx181ek 182 10 UPDRS UPDRS NNP cord-333986-xkx181ek 182 11 scores score NNS cord-333986-xkx181ek 182 12 , , , cord-333986-xkx181ek 182 13 were be VBD cord-333986-xkx181ek 182 14 significantly significantly RB cord-333986-xkx181ek 182 15 smaller small JJR cord-333986-xkx181ek 182 16 for for IN cord-333986-xkx181ek 182 17 PwP pwp NN cord-333986-xkx181ek 182 18 using use VBG cord-333986-xkx181ek 183 1 a a DT cord-333986-xkx181ek 183 2 high high JJ cord-333986-xkx181ek 183 3 - - HYPH cord-333986-xkx181ek 183 4 intensity intensity NN cord-333986-xkx181ek 183 5 treadmill treadmill NN cord-333986-xkx181ek 183 6 exercise exercise NN cord-333986-xkx181ek 183 7 routine routine NN cord-333986-xkx181ek 183 8 than than IN cord-333986-xkx181ek 183 9 moderate moderate JJ cord-333986-xkx181ek 183 10 - - HYPH cord-333986-xkx181ek 183 11 intensity intensity NN cord-333986-xkx181ek 183 12 exercise exercise NN cord-333986-xkx181ek 183 13 and and CC cord-333986-xkx181ek 183 14 control control NN cord-333986-xkx181ek 183 15 groups group NNS cord-333986-xkx181ek 183 16 [ [ -LRB- cord-333986-xkx181ek 183 17 101 101 CD cord-333986-xkx181ek 183 18 ] ] -RRB- cord-333986-xkx181ek 183 19 . . . cord-333986-xkx181ek 184 1 A a DT cord-333986-xkx181ek 184 2 significant significant JJ cord-333986-xkx181ek 184 3 trend trend NN cord-333986-xkx181ek 184 4 is be VBZ cord-333986-xkx181ek 184 5 the the DT cord-333986-xkx181ek 184 6 incorporation incorporation NN cord-333986-xkx181ek 184 7 and and CC cord-333986-xkx181ek 184 8 utilization utilization NN cord-333986-xkx181ek 184 9 of of IN cord-333986-xkx181ek 184 10 exercise exercise NN cord-333986-xkx181ek 184 11 in in IN cord-333986-xkx181ek 184 12 optimizing optimize VBG cord-333986-xkx181ek 184 13 the the DT cord-333986-xkx181ek 184 14 care care NN cord-333986-xkx181ek 184 15 of of IN cord-333986-xkx181ek 184 16 PwP PwP NNP cord-333986-xkx181ek 184 17 [ [ -LRB- cord-333986-xkx181ek 184 18 9 9 CD cord-333986-xkx181ek 184 19 , , , cord-333986-xkx181ek 184 20 102 102 CD cord-333986-xkx181ek 184 21 ] ] -RRB- cord-333986-xkx181ek 184 22 , , , cord-333986-xkx181ek 184 23 and and CC cord-333986-xkx181ek 184 24 there there EX cord-333986-xkx181ek 184 25 are be VBP cord-333986-xkx181ek 184 26 numerous numerous JJ cord-333986-xkx181ek 184 27 PD pd NN cord-333986-xkx181ek 184 28 - - HYPH cord-333986-xkx181ek 184 29 directed direct VBN cord-333986-xkx181ek 184 30 exercise exercise NN cord-333986-xkx181ek 184 31 programs program NNS cord-333986-xkx181ek 184 32 / / SYM cord-333986-xkx181ek 184 33 routines routine NNS cord-333986-xkx181ek 184 34 [ [ -LRB- cord-333986-xkx181ek 184 35 10 10 CD cord-333986-xkx181ek 184 36 , , , cord-333986-xkx181ek 184 37 87 87 CD cord-333986-xkx181ek 184 38 , , , cord-333986-xkx181ek 184 39 88 88 CD cord-333986-xkx181ek 184 40 , , , cord-333986-xkx181ek 184 41 90 90 CD cord-333986-xkx181ek 184 42 , , , cord-333986-xkx181ek 184 43 [ [ -LRB- cord-333986-xkx181ek 184 44 103 103 CD cord-333986-xkx181ek 184 45 ] ] -RRB- cord-333986-xkx181ek 184 46 [ [ -LRB- cord-333986-xkx181ek 184 47 104 104 CD cord-333986-xkx181ek 184 48 ] ] -RRB- cord-333986-xkx181ek 184 49 [ [ -LRB- cord-333986-xkx181ek 184 50 105 105 CD cord-333986-xkx181ek 184 51 ] ] -RRB- cord-333986-xkx181ek 184 52 [ [ -LRB- cord-333986-xkx181ek 184 53 106 106 CD cord-333986-xkx181ek 184 54 ] ] -RRB- cord-333986-xkx181ek 184 55 . . . cord-333986-xkx181ek 185 1 Expectantly expectantly RB cord-333986-xkx181ek 185 2 , , , cord-333986-xkx181ek 185 3 future future JJ cord-333986-xkx181ek 185 4 studies study NNS cord-333986-xkx181ek 185 5 will will MD cord-333986-xkx181ek 185 6 continue continue VB cord-333986-xkx181ek 185 7 to to TO cord-333986-xkx181ek 185 8 compare compare VB cord-333986-xkx181ek 185 9 the the DT cord-333986-xkx181ek 185 10 impact impact NN cord-333986-xkx181ek 185 11 of of IN cord-333986-xkx181ek 185 12 moderate moderate JJ cord-333986-xkx181ek 185 13 - - HYPH cord-333986-xkx181ek 185 14 intensity intensity NN cord-333986-xkx181ek 185 15 and and CC cord-333986-xkx181ek 185 16 high high JJ cord-333986-xkx181ek 185 17 - - HYPH cord-333986-xkx181ek 185 18 intensity intensity NN cord-333986-xkx181ek 185 19 exercise exercise NN cord-333986-xkx181ek 185 20 programs program NNS cord-333986-xkx181ek 185 21 on on IN cord-333986-xkx181ek 185 22 neuroplasticity neuroplasticity NN cord-333986-xkx181ek 185 23 in in IN cord-333986-xkx181ek 185 24 combination combination NN cord-333986-xkx181ek 185 25 with with IN cord-333986-xkx181ek 185 26 the the DT cord-333986-xkx181ek 185 27 investigation investigation NN cord-333986-xkx181ek 185 28 into into IN cord-333986-xkx181ek 185 29 the the DT cord-333986-xkx181ek 185 30 overall overall JJ cord-333986-xkx181ek 185 31 health health NN cord-333986-xkx181ek 185 32 impact impact NN cord-333986-xkx181ek 185 33 of of IN cord-333986-xkx181ek 185 34 exercise exercise NN cord-333986-xkx181ek 185 35 in in IN cord-333986-xkx181ek 185 36 PD PD NNP cord-333986-xkx181ek 185 37 . . . cord-333986-xkx181ek 186 1 Understanding understand VBG cord-333986-xkx181ek 186 2 how how WRB cord-333986-xkx181ek 186 3 exercise exercise NN cord-333986-xkx181ek 186 4 promotes promote VBZ cord-333986-xkx181ek 186 5 neuroplasticity neuroplasticity NN cord-333986-xkx181ek 186 6 in in IN cord-333986-xkx181ek 186 7 humans human NNS cord-333986-xkx181ek 186 8 has have VBZ cord-333986-xkx181ek 186 9 been be VBN cord-333986-xkx181ek 186 10 difficult difficult JJ cord-333986-xkx181ek 186 11 . . . cord-333986-xkx181ek 187 1 A a DT cord-333986-xkx181ek 187 2 few few JJ cord-333986-xkx181ek 187 3 obstacles obstacle NNS cord-333986-xkx181ek 187 4 include include VBP cord-333986-xkx181ek 187 5 which which WDT cord-333986-xkx181ek 187 6 biological biological JJ cord-333986-xkx181ek 187 7 markers marker NNS cord-333986-xkx181ek 187 8 are be VBP cord-333986-xkx181ek 187 9 the the DT cord-333986-xkx181ek 187 10 most most RBS cord-333986-xkx181ek 187 11 useful useful JJ cord-333986-xkx181ek 187 12 for for IN cord-333986-xkx181ek 187 13 measuring measure VBG cord-333986-xkx181ek 187 14 neuroplasticity neuroplasticity NN cord-333986-xkx181ek 187 15 and and CC cord-333986-xkx181ek 187 16 what what WDT cord-333986-xkx181ek 187 17 imaging imaging NN cord-333986-xkx181ek 187 18 techniques technique NNS cord-333986-xkx181ek 187 19 / / SYM cord-333986-xkx181ek 187 20 tools tool NNS cord-333986-xkx181ek 187 21 would would MD cord-333986-xkx181ek 187 22 be be VB cord-333986-xkx181ek 187 23 most most RBS cord-333986-xkx181ek 187 24 helpful helpful JJ cord-333986-xkx181ek 187 25 to to TO cord-333986-xkx181ek 187 26 document document VB cord-333986-xkx181ek 187 27 changes change NNS cord-333986-xkx181ek 187 28 in in IN cord-333986-xkx181ek 187 29 the the DT cord-333986-xkx181ek 187 30 neural neural JJ cord-333986-xkx181ek 187 31 networks network NNS cord-333986-xkx181ek 187 32 [ [ -LRB- cord-333986-xkx181ek 187 33 107 107 CD cord-333986-xkx181ek 187 34 ] ] -RRB- cord-333986-xkx181ek 187 35 . . . cord-333986-xkx181ek 188 1 A a DT cord-333986-xkx181ek 188 2 clinical clinical JJ cord-333986-xkx181ek 188 3 trial trial NN cord-333986-xkx181ek 188 4 [ [ -LRB- cord-333986-xkx181ek 188 5 108 108 CD cord-333986-xkx181ek 188 6 ] ] -RRB- cord-333986-xkx181ek 188 7 and and CC cord-333986-xkx181ek 188 8 a a DT cord-333986-xkx181ek 188 9 feasibility feasibility NN cord-333986-xkx181ek 188 10 study study NN cord-333986-xkx181ek 188 11 [ [ -LRB- cord-333986-xkx181ek 188 12 109 109 CD cord-333986-xkx181ek 188 13 ] ] -RRB- cord-333986-xkx181ek 188 14 for for IN cord-333986-xkx181ek 188 15 exercise exercise NN cord-333986-xkx181ek 188 16 - - HYPH cord-333986-xkx181ek 188 17 induced induce VBN cord-333986-xkx181ek 188 18 neuroplasticity neuroplasticity NN cord-333986-xkx181ek 188 19 in in IN cord-333986-xkx181ek 188 20 PD PD NNP cord-333986-xkx181ek 188 21 are be VBP cord-333986-xkx181ek 188 22 currently currently RB cord-333986-xkx181ek 188 23 underway underway JJ cord-333986-xkx181ek 188 24 . . . cord-333986-xkx181ek 189 1 The the DT cord-333986-xkx181ek 189 2 research research NN cord-333986-xkx181ek 189 3 connection connection NN cord-333986-xkx181ek 189 4 between between IN cord-333986-xkx181ek 189 5 moderate moderate JJ cord-333986-xkx181ek 189 6 exercise exercise NN cord-333986-xkx181ek 189 7 and and CC cord-333986-xkx181ek 189 8 reduced reduce VBN cord-333986-xkx181ek 189 9 occurrence occurrence NN cord-333986-xkx181ek 189 10 of of IN cord-333986-xkx181ek 189 11 URTI URTI NNP cord-333986-xkx181ek 189 12 suggests suggest VBZ cord-333986-xkx181ek 189 13 moderate moderate JJ cord-333986-xkx181ek 189 14 exercise exercise NN cord-333986-xkx181ek 189 15 as as IN cord-333986-xkx181ek 189 16 a a DT cord-333986-xkx181ek 189 17 potential potential JJ cord-333986-xkx181ek 189 18 protective protective JJ cord-333986-xkx181ek 189 19 measure measure NN cord-333986-xkx181ek 189 20 against against IN cord-333986-xkx181ek 189 21 infection infection NN cord-333986-xkx181ek 189 22 with with IN cord-333986-xkx181ek 189 23 COVID-19 COVID-19 NNP cord-333986-xkx181ek 189 24 and and CC cord-333986-xkx181ek 189 25 as as IN cord-333986-xkx181ek 189 26 a a DT cord-333986-xkx181ek 189 27 possible possible JJ cord-333986-xkx181ek 189 28 mitigator mitigator NN cord-333986-xkx181ek 189 29 of of IN cord-333986-xkx181ek 189 30 symptoms symptom NNS cord-333986-xkx181ek 189 31 if if IN cord-333986-xkx181ek 189 32 COVID-19 COVID-19 NNP cord-333986-xkx181ek 189 33 is be VBZ cord-333986-xkx181ek 189 34 acquired acquire VBN cord-333986-xkx181ek 189 35 [ [ -LRB- cord-333986-xkx181ek 189 36 48 48 CD cord-333986-xkx181ek 189 37 ] ] -RRB- cord-333986-xkx181ek 189 38 [ [ -LRB- cord-333986-xkx181ek 189 39 49 49 CD cord-333986-xkx181ek 189 40 ] ] -RRB- cord-333986-xkx181ek 189 41 [ [ -LRB- cord-333986-xkx181ek 189 42 50 50 CD cord-333986-xkx181ek 189 43 ] ] -RRB- cord-333986-xkx181ek 189 44 [ [ -LRB- cord-333986-xkx181ek 189 45 51 51 CD cord-333986-xkx181ek 189 46 ] ] -RRB- cord-333986-xkx181ek 189 47 [ [ -LRB- cord-333986-xkx181ek 189 48 52 52 CD cord-333986-xkx181ek 189 49 ] ] -RRB- cord-333986-xkx181ek 189 50 [ [ -LRB- cord-333986-xkx181ek 189 51 53 53 CD cord-333986-xkx181ek 189 52 ] ] -RRB- cord-333986-xkx181ek 189 53 . . . cord-333986-xkx181ek 190 1 We -PRON- PRP cord-333986-xkx181ek 190 2 suggest suggest VBP cord-333986-xkx181ek 190 3 that that IN cord-333986-xkx181ek 190 4 the the DT cord-333986-xkx181ek 190 5 following follow VBG cord-333986-xkx181ek 190 6 four four CD cord-333986-xkx181ek 190 7 responses response NNS cord-333986-xkx181ek 190 8 of of IN cord-333986-xkx181ek 190 9 the the DT cord-333986-xkx181ek 190 10 immune immune JJ cord-333986-xkx181ek 190 11 system system NN cord-333986-xkx181ek 190 12 to to TO cord-333986-xkx181ek 190 13 moderate moderate JJ cord-333986-xkx181ek 190 14 exercise exercise NN cord-333986-xkx181ek 190 15 could could MD cord-333986-xkx181ek 190 16 act act VB cord-333986-xkx181ek 190 17 as as IN cord-333986-xkx181ek 190 18 potential potential JJ cord-333986-xkx181ek 190 19 nonpharmacological nonpharmacological JJ cord-333986-xkx181ek 190 20 prophylaxis prophylaxis NN cord-333986-xkx181ek 190 21 for for IN cord-333986-xkx181ek 190 22 COVID-19 COVID-19 NNP cord-333986-xkx181ek 190 23 . . . cord-333986-xkx181ek 191 1 We -PRON- PRP cord-333986-xkx181ek 191 2 described describe VBD cord-333986-xkx181ek 191 3 earlier early RBR cord-333986-xkx181ek 191 4 in in IN cord-333986-xkx181ek 191 5 the the DT cord-333986-xkx181ek 191 6 review review NN cord-333986-xkx181ek 191 7 that that WDT cord-333986-xkx181ek 191 8 intense intense JJ cord-333986-xkx181ek 191 9 exercise exercise NN cord-333986-xkx181ek 191 10 can can MD cord-333986-xkx181ek 191 11 result result VB cord-333986-xkx181ek 191 12 in in IN cord-333986-xkx181ek 191 13 immunosuppression immunosuppression NN cord-333986-xkx181ek 191 14 . . . cord-333986-xkx181ek 192 1 In in IN cord-333986-xkx181ek 192 2 contrast contrast NN cord-333986-xkx181ek 192 3 , , , cord-333986-xkx181ek 192 4 moderate moderate JJ cord-333986-xkx181ek 192 5 - - HYPH cord-333986-xkx181ek 192 6 intensity intensity NN cord-333986-xkx181ek 192 7 exercise exercise NN cord-333986-xkx181ek 192 8 can can MD cord-333986-xkx181ek 192 9 improve improve VB cord-333986-xkx181ek 192 10 immune immune JJ cord-333986-xkx181ek 192 11 function function NN cord-333986-xkx181ek 192 12 , , , cord-333986-xkx181ek 192 13 potentially potentially RB cord-333986-xkx181ek 192 14 reducing reduce VBG cord-333986-xkx181ek 192 15 the the DT cord-333986-xkx181ek 192 16 risk risk NN cord-333986-xkx181ek 192 17 and and CC cord-333986-xkx181ek 192 18 severity severity NN cord-333986-xkx181ek 192 19 of of IN cord-333986-xkx181ek 192 20 viral viral JJ cord-333986-xkx181ek 192 21 respiratory respiratory JJ cord-333986-xkx181ek 192 22 infections infection NNS cord-333986-xkx181ek 192 23 [ [ -LRB- cord-333986-xkx181ek 192 24 27 27 CD cord-333986-xkx181ek 192 25 , , , cord-333986-xkx181ek 192 26 53 53 CD cord-333986-xkx181ek 192 27 , , , cord-333986-xkx181ek 192 28 65 65 CD cord-333986-xkx181ek 192 29 , , , cord-333986-xkx181ek 192 30 66 66 CD cord-333986-xkx181ek 192 31 ] ] -RRB- cord-333986-xkx181ek 192 32 . . . cord-333986-xkx181ek 193 1 When when WRB cord-333986-xkx181ek 193 2 exposing expose VBG cord-333986-xkx181ek 193 3 the the DT cord-333986-xkx181ek 193 4 body body NN cord-333986-xkx181ek 193 5 to to TO cord-333986-xkx181ek 193 6 moderate moderate JJ cord-333986-xkx181ek 193 7 exercise exercise NN cord-333986-xkx181ek 193 8 training training NN cord-333986-xkx181ek 193 9 , , , cord-333986-xkx181ek 193 10 there there EX cord-333986-xkx181ek 193 11 is be VBZ cord-333986-xkx181ek 193 12 an an DT cord-333986-xkx181ek 193 13 initial initial JJ cord-333986-xkx181ek 193 14 increase increase NN cord-333986-xkx181ek 193 15 in in IN cord-333986-xkx181ek 193 16 immunosurveillance immunosurveillance NN cord-333986-xkx181ek 193 17 and and CC cord-333986-xkx181ek 193 18 an an DT cord-333986-xkx181ek 193 19 overall overall JJ cord-333986-xkx181ek 193 20 reduction reduction NN cord-333986-xkx181ek 193 21 in in IN cord-333986-xkx181ek 193 22 excessive excessive JJ cord-333986-xkx181ek 193 23 local local JJ cord-333986-xkx181ek 193 24 inflammation inflammation NN cord-333986-xkx181ek 193 25 and and CC cord-333986-xkx181ek 193 26 inflammatory inflammatory JJ cord-333986-xkx181ek 193 27 markers marker NNS cord-333986-xkx181ek 193 28 . . . cord-333986-xkx181ek 194 1 While while IN cord-333986-xkx181ek 194 2 moderate moderate JJ cord-333986-xkx181ek 194 3 exercise exercise NN cord-333986-xkx181ek 194 4 shifts shift VBZ cord-333986-xkx181ek 194 5 the the DT cord-333986-xkx181ek 194 6 cytokine cytokine NN cord-333986-xkx181ek 194 7 profile profile NN cord-333986-xkx181ek 194 8 slightly slightly RB cord-333986-xkx181ek 194 9 to to IN cord-333986-xkx181ek 194 10 T T NNP cord-333986-xkx181ek 194 11 H h NN cord-333986-xkx181ek 194 12 2 2 CD cord-333986-xkx181ek 194 13 cells cell NNS cord-333986-xkx181ek 194 14 , , , cord-333986-xkx181ek 194 15 an an DT cord-333986-xkx181ek 194 16 active active JJ cord-333986-xkx181ek 194 17 T t NN cord-333986-xkx181ek 194 18 H h NN cord-333986-xkx181ek 194 19 1 1 CD cord-333986-xkx181ek 194 20 cell cell NN cord-333986-xkx181ek 194 21 response response NN cord-333986-xkx181ek 194 22 is be VBZ cord-333986-xkx181ek 194 23 still still RB cord-333986-xkx181ek 194 24 present present JJ cord-333986-xkx181ek 194 25 . . . cord-333986-xkx181ek 195 1 A a DT cord-333986-xkx181ek 195 2 T t NN cord-333986-xkx181ek 195 3 H h NN cord-333986-xkx181ek 195 4 1 1 CD cord-333986-xkx181ek 195 5 inflammatory inflammatory JJ cord-333986-xkx181ek 195 6 immune immune JJ cord-333986-xkx181ek 195 7 response response NN cord-333986-xkx181ek 195 8 leads lead VBZ cord-333986-xkx181ek 195 9 to to IN cord-333986-xkx181ek 195 10 the the DT cord-333986-xkx181ek 195 11 up up JJ cord-333986-xkx181ek 195 12 - - HYPH cord-333986-xkx181ek 195 13 regulation regulation NN cord-333986-xkx181ek 195 14 of of IN cord-333986-xkx181ek 195 15 pro pro JJ cord-333986-xkx181ek 195 16 - - JJ cord-333986-xkx181ek 195 17 inflammatory inflammatory JJ cord-333986-xkx181ek 195 18 cytokines cytokine NNS cord-333986-xkx181ek 195 19 , , , cord-333986-xkx181ek 195 20 especially especially RB cord-333986-xkx181ek 195 21 IFN IFN NNP cord-333986-xkx181ek 195 22 - - HYPH cord-333986-xkx181ek 195 23 γ γ NNP cord-333986-xkx181ek 195 24 . . . cord-333986-xkx181ek 196 1 A a DT cord-333986-xkx181ek 196 2 T t NN cord-333986-xkx181ek 196 3 H h NN cord-333986-xkx181ek 196 4 1 1 CD cord-333986-xkx181ek 196 5 modulated modulate VBD cord-333986-xkx181ek 196 6 cytotoxic cytotoxic JJ cord-333986-xkx181ek 196 7 response response NN cord-333986-xkx181ek 196 8 is be VBZ cord-333986-xkx181ek 196 9 needed need VBN cord-333986-xkx181ek 196 10 for for IN cord-333986-xkx181ek 196 11 early early JJ cord-333986-xkx181ek 196 12 antiviral antiviral JJ cord-333986-xkx181ek 196 13 clearance clearance NN cord-333986-xkx181ek 196 14 activity activity NN cord-333986-xkx181ek 196 15 , , , cord-333986-xkx181ek 196 16 and and CC cord-333986-xkx181ek 196 17 a a DT cord-333986-xkx181ek 196 18 T t NN cord-333986-xkx181ek 196 19 H h NN cord-333986-xkx181ek 196 20 2 2 CD cord-333986-xkx181ek 196 21 response response NN cord-333986-xkx181ek 196 22 is be VBZ cord-333986-xkx181ek 196 23 necessary necessary JJ cord-333986-xkx181ek 196 24 for for IN cord-333986-xkx181ek 196 25 the the DT cord-333986-xkx181ek 196 26 production production NN cord-333986-xkx181ek 196 27 of of IN cord-333986-xkx181ek 196 28 viral viral JJ cord-333986-xkx181ek 196 29 neutralizing neutralize VBG cord-333986-xkx181ek 196 30 antibodies antibody NNS cord-333986-xkx181ek 196 31 , , , cord-333986-xkx181ek 196 32 infection infection NN cord-333986-xkx181ek 196 33 eradication eradication NN cord-333986-xkx181ek 196 34 , , , cord-333986-xkx181ek 196 35 and and CC cord-333986-xkx181ek 196 36 modulation modulation NN cord-333986-xkx181ek 196 37 to to TO cord-333986-xkx181ek 196 38 prevent prevent VB cord-333986-xkx181ek 196 39 over over IN cord-333986-xkx181ek 196 40 inflammation inflammation NN cord-333986-xkx181ek 196 41 . . . cord-333986-xkx181ek 197 1 In in IN cord-333986-xkx181ek 197 2 contrast contrast NN cord-333986-xkx181ek 197 3 to to IN cord-333986-xkx181ek 197 4 moderate moderate JJ cord-333986-xkx181ek 197 5 exercise exercise NN cord-333986-xkx181ek 197 6 , , , cord-333986-xkx181ek 197 7 vigorous vigorous JJ cord-333986-xkx181ek 197 8 exercise exercise NN cord-333986-xkx181ek 197 9 creates create VBZ cord-333986-xkx181ek 197 10 an an DT cord-333986-xkx181ek 197 11 even even RB cord-333986-xkx181ek 197 12 more more RBR cord-333986-xkx181ek 197 13 polarized polarized JJ cord-333986-xkx181ek 197 14 T t NN cord-333986-xkx181ek 197 15 H h NN cord-333986-xkx181ek 197 16 2 2 CD cord-333986-xkx181ek 197 17 to to IN cord-333986-xkx181ek 197 18 T T NNP cord-333986-xkx181ek 197 19 H h NN cord-333986-xkx181ek 197 20 1 1 CD cord-333986-xkx181ek 197 21 cytokine cytokine NN cord-333986-xkx181ek 197 22 profile profile NN cord-333986-xkx181ek 197 23 , , , cord-333986-xkx181ek 197 24 oversuppressing oversuppresse VBG cord-333986-xkx181ek 197 25 the the DT cord-333986-xkx181ek 197 26 immune immune JJ cord-333986-xkx181ek 197 27 system system NN cord-333986-xkx181ek 197 28 . . . cord-333986-xkx181ek 198 1 These these DT cord-333986-xkx181ek 198 2 findings finding NNS cord-333986-xkx181ek 198 3 provide provide VBP cord-333986-xkx181ek 198 4 evidence evidence NN cord-333986-xkx181ek 198 5 for for IN cord-333986-xkx181ek 198 6 positive positive JJ cord-333986-xkx181ek 198 7 viral viral JJ cord-333986-xkx181ek 198 8 respiratory respiratory JJ cord-333986-xkx181ek 198 9 outcomes outcome NNS cord-333986-xkx181ek 198 10 in in IN cord-333986-xkx181ek 198 11 individuals individual NNS cord-333986-xkx181ek 198 12 who who WP cord-333986-xkx181ek 198 13 participate participate VBP cord-333986-xkx181ek 198 14 in in IN cord-333986-xkx181ek 198 15 moderate moderate JJ cord-333986-xkx181ek 198 16 versus versus IN cord-333986-xkx181ek 198 17 vigorous vigorous JJ cord-333986-xkx181ek 198 18 exercise exercise NN cord-333986-xkx181ek 198 19 , , , cord-333986-xkx181ek 198 20 and and CC cord-333986-xkx181ek 198 21 the the DT cord-333986-xkx181ek 198 22 balance balance NN cord-333986-xkx181ek 198 23 of of IN cord-333986-xkx181ek 198 24 moderate moderate JJ cord-333986-xkx181ek 198 25 exercise exercise NN cord-333986-xkx181ek 198 26 can can MD cord-333986-xkx181ek 198 27 maintain maintain VB cord-333986-xkx181ek 198 28 between between IN cord-333986-xkx181ek 198 29 the the DT cord-333986-xkx181ek 198 30 positive positive JJ cord-333986-xkx181ek 198 31 benefits benefit NNS cord-333986-xkx181ek 198 32 of of IN cord-333986-xkx181ek 198 33 pro pro JJ cord-333986-xkx181ek 198 34 - - JJ cord-333986-xkx181ek 198 35 and and CC cord-333986-xkx181ek 198 36 anti anti JJ cord-333986-xkx181ek 198 37 - - JJ cord-333986-xkx181ek 198 38 inflammation inflammation NN cord-333986-xkx181ek 198 39 when when WRB cord-333986-xkx181ek 198 40 fighting fight VBG cord-333986-xkx181ek 198 41 a a DT cord-333986-xkx181ek 198 42 viral viral JJ cord-333986-xkx181ek 198 43 infection infection NN cord-333986-xkx181ek 198 44 such such JJ cord-333986-xkx181ek 198 45 as as IN cord-333986-xkx181ek 198 46 COVID-19 COVID-19 NNP cord-333986-xkx181ek 198 47 . . . cord-333986-xkx181ek 199 1 Moderate moderate JJ cord-333986-xkx181ek 199 2 aerobic aerobic JJ cord-333986-xkx181ek 199 3 exercise exercise NN cord-333986-xkx181ek 199 4 has have VBZ cord-333986-xkx181ek 199 5 the the DT cord-333986-xkx181ek 199 6 potential potential NN cord-333986-xkx181ek 199 7 to to TO cord-333986-xkx181ek 199 8 restore restore VB cord-333986-xkx181ek 199 9 the the DT cord-333986-xkx181ek 199 10 elasticity elasticity NN cord-333986-xkx181ek 199 11 and and CC cord-333986-xkx181ek 199 12 strength strength NN cord-333986-xkx181ek 199 13 of of IN cord-333986-xkx181ek 199 14 lung lung NN cord-333986-xkx181ek 199 15 tissue tissue NN cord-333986-xkx181ek 199 16 and and CC cord-333986-xkx181ek 199 17 respiratory respiratory JJ cord-333986-xkx181ek 199 18 muscles muscle NNS cord-333986-xkx181ek 199 19 . . . cord-333986-xkx181ek 200 1 Park Park NNP cord-333986-xkx181ek 200 2 and and CC cord-333986-xkx181ek 200 3 Han Han NNP cord-333986-xkx181ek 200 4 found find VBD cord-333986-xkx181ek 200 5 that that IN cord-333986-xkx181ek 200 6 in in IN cord-333986-xkx181ek 200 7 women woman NNS cord-333986-xkx181ek 200 8 over over IN cord-333986-xkx181ek 200 9 the the DT cord-333986-xkx181ek 200 10 age age NN cord-333986-xkx181ek 200 11 of of IN cord-333986-xkx181ek 200 12 65 65 CD cord-333986-xkx181ek 200 13 , , , cord-333986-xkx181ek 200 14 aerobic aerobic JJ cord-333986-xkx181ek 200 15 exercise exercise NN cord-333986-xkx181ek 200 16 on on IN cord-333986-xkx181ek 200 17 a a DT cord-333986-xkx181ek 200 18 treadmill treadmill NN cord-333986-xkx181ek 200 19 increased increase VBN cord-333986-xkx181ek 200 20 Forced force VBN cord-333986-xkx181ek 200 21 Vital vital JJ cord-333986-xkx181ek 200 22 Capacity Capacity NNP cord-333986-xkx181ek 200 23 ( ( -LRB- cord-333986-xkx181ek 200 24 FVC FVC NNP cord-333986-xkx181ek 200 25 ) ) -RRB- cord-333986-xkx181ek 200 26 and and CC cord-333986-xkx181ek 200 27 Forced force VBN cord-333986-xkx181ek 200 28 Expiratory Expiratory NNP cord-333986-xkx181ek 200 29 Volume Volume NNP cord-333986-xkx181ek 200 30 in in IN cord-333986-xkx181ek 200 31 1 1 CD cord-333986-xkx181ek 200 32 s s NNPS cord-333986-xkx181ek 200 33 ( ( -LRB- cord-333986-xkx181ek 200 34 FEV FEV NNP cord-333986-xkx181ek 200 35 1 1 CD cord-333986-xkx181ek 200 36 ) ) -RRB- cord-333986-xkx181ek 200 37 , , , cord-333986-xkx181ek 200 38 indicating indicate VBG cord-333986-xkx181ek 200 39 an an DT cord-333986-xkx181ek 200 40 improvement improvement NN cord-333986-xkx181ek 200 41 in in IN cord-333986-xkx181ek 200 42 markers marker NNS cord-333986-xkx181ek 200 43 of of IN cord-333986-xkx181ek 200 44 alveolar alveolar JJ cord-333986-xkx181ek 200 45 compliance compliance NN cord-333986-xkx181ek 200 46 and and CC cord-333986-xkx181ek 200 47 elasticity elasticity NN cord-333986-xkx181ek 200 48 and and CC cord-333986-xkx181ek 200 49 reduced reduce VBN cord-333986-xkx181ek 200 50 resistance resistance NN cord-333986-xkx181ek 200 51 to to IN cord-333986-xkx181ek 200 52 airflow airflow VB cord-333986-xkx181ek 200 53 in in IN cord-333986-xkx181ek 200 54 the the DT cord-333986-xkx181ek 200 55 respiratory respiratory JJ cord-333986-xkx181ek 200 56 tract tract NN cord-333986-xkx181ek 200 57 [ [ -LRB- cord-333986-xkx181ek 200 58 110 110 CD cord-333986-xkx181ek 200 59 ] ] -RRB- cord-333986-xkx181ek 200 60 . . . cord-333986-xkx181ek 201 1 Taskin Taskin NNP cord-333986-xkx181ek 201 2 et et NNP cord-333986-xkx181ek 201 3 al al NNP cord-333986-xkx181ek 201 4 . . . cord-333986-xkx181ek 202 1 also also RB cord-333986-xkx181ek 202 2 found find VBD cord-333986-xkx181ek 202 3 that that IN cord-333986-xkx181ek 202 4 moderate moderate JJ cord-333986-xkx181ek 202 5 aerobic aerobic JJ cord-333986-xkx181ek 202 6 exercise exercise NN cord-333986-xkx181ek 202 7 increased increase VBD cord-333986-xkx181ek 202 8 the the DT cord-333986-xkx181ek 202 9 strength strength NN cord-333986-xkx181ek 202 10 of of IN cord-333986-xkx181ek 202 11 respiratory respiratory JJ cord-333986-xkx181ek 202 12 muscles muscle NNS cord-333986-xkx181ek 202 13 , , , cord-333986-xkx181ek 202 14 inspiratory inspiratory JJ cord-333986-xkx181ek 202 15 muscle muscle NN cord-333986-xkx181ek 202 16 performance performance NN cord-333986-xkx181ek 202 17 , , , cord-333986-xkx181ek 202 18 and and CC cord-333986-xkx181ek 202 19 diminished diminish VBD cord-333986-xkx181ek 202 20 the the DT cord-333986-xkx181ek 202 21 perception perception NN cord-333986-xkx181ek 202 22 of of IN cord-333986-xkx181ek 202 23 dyspnea dyspnea NN cord-333986-xkx181ek 202 24 in in IN cord-333986-xkx181ek 202 25 patients patient NNS cord-333986-xkx181ek 202 26 with with IN cord-333986-xkx181ek 202 27 ankylosing ankylose VBG cord-333986-xkx181ek 202 28 spondylitis spondylitis NN cord-333986-xkx181ek 202 29 [ [ -LRB- cord-333986-xkx181ek 202 30 111 111 CD cord-333986-xkx181ek 202 31 ] ] -RRB- cord-333986-xkx181ek 202 32 . . . cord-333986-xkx181ek 203 1 These these DT cord-333986-xkx181ek 203 2 findings finding NNS cord-333986-xkx181ek 203 3 provide provide VBP cord-333986-xkx181ek 203 4 evidence evidence NN cord-333986-xkx181ek 203 5 for for IN cord-333986-xkx181ek 203 6 potential potential JJ cord-333986-xkx181ek 203 7 protective protective JJ cord-333986-xkx181ek 203 8 and and CC cord-333986-xkx181ek 203 9 therapeutic therapeutic JJ cord-333986-xkx181ek 203 10 effects effect NNS cord-333986-xkx181ek 203 11 of of IN cord-333986-xkx181ek 203 12 moderate moderate JJ cord-333986-xkx181ek 203 13 exercise exercise NN cord-333986-xkx181ek 203 14 on on IN cord-333986-xkx181ek 203 15 lung lung NN cord-333986-xkx181ek 203 16 integrity integrity NN cord-333986-xkx181ek 203 17 when when WRB cord-333986-xkx181ek 203 18 faced face VBN cord-333986-xkx181ek 203 19 with with IN cord-333986-xkx181ek 203 20 the the DT cord-333986-xkx181ek 203 21 risk risk NN cord-333986-xkx181ek 203 22 of of IN cord-333986-xkx181ek 203 23 COVID-19 COVID-19 NNP cord-333986-xkx181ek 203 24 . . . cord-333986-xkx181ek 204 1 Moderate moderate JJ cord-333986-xkx181ek 204 2 aerobic aerobic JJ cord-333986-xkx181ek 204 3 exercise exercise NN cord-333986-xkx181ek 204 4 works work VBZ cord-333986-xkx181ek 204 5 to to TO cord-333986-xkx181ek 204 6 reduce reduce VB cord-333986-xkx181ek 204 7 oxidative oxidative JJ cord-333986-xkx181ek 204 8 stress stress NN cord-333986-xkx181ek 204 9 , , , cord-333986-xkx181ek 204 10 a a DT cord-333986-xkx181ek 204 11 frequent frequent JJ cord-333986-xkx181ek 204 12 instigator instigator NN cord-333986-xkx181ek 204 13 of of IN cord-333986-xkx181ek 204 14 acute acute JJ cord-333986-xkx181ek 204 15 and and CC cord-333986-xkx181ek 204 16 chronic chronic JJ cord-333986-xkx181ek 204 17 lung lung NN cord-333986-xkx181ek 204 18 injury injury NN cord-333986-xkx181ek 204 19 , , , cord-333986-xkx181ek 204 20 through through IN cord-333986-xkx181ek 204 21 the the DT cord-333986-xkx181ek 204 22 decreased decreased JJ cord-333986-xkx181ek 204 23 production production NN cord-333986-xkx181ek 204 24 of of IN cord-333986-xkx181ek 204 25 reactive reactive JJ cord-333986-xkx181ek 204 26 oxygen oxygen NN cord-333986-xkx181ek 204 27 species specie NNS cord-333986-xkx181ek 204 28 [ [ -LRB- cord-333986-xkx181ek 204 29 112 112 CD cord-333986-xkx181ek 204 30 , , , cord-333986-xkx181ek 204 31 113 113 CD cord-333986-xkx181ek 204 32 ] ] -RRB- cord-333986-xkx181ek 204 33 . . . cord-333986-xkx181ek 205 1 Toledo Toledo NNP cord-333986-xkx181ek 205 2 et et NNP cord-333986-xkx181ek 205 3 al al NNP cord-333986-xkx181ek 205 4 . . . cord-333986-xkx181ek 206 1 found find VBD cord-333986-xkx181ek 206 2 evidence evidence NN cord-333986-xkx181ek 206 3 for for IN cord-333986-xkx181ek 206 4 the the DT cord-333986-xkx181ek 206 5 attenuation attenuation NN cord-333986-xkx181ek 206 6 of of IN cord-333986-xkx181ek 206 7 pulmonary pulmonary JJ cord-333986-xkx181ek 206 8 disease disease NN cord-333986-xkx181ek 206 9 development development NN cord-333986-xkx181ek 206 10 as as IN cord-333986-xkx181ek 206 11 a a DT cord-333986-xkx181ek 206 12 result result NN cord-333986-xkx181ek 206 13 of of IN cord-333986-xkx181ek 206 14 moderate moderate JJ cord-333986-xkx181ek 206 15 exercise exercise NN cord-333986-xkx181ek 206 16 . . . cord-333986-xkx181ek 207 1 They -PRON- PRP cord-333986-xkx181ek 207 2 found find VBD cord-333986-xkx181ek 207 3 that that IN cord-333986-xkx181ek 207 4 moderate moderate JJ cord-333986-xkx181ek 207 5 aerobic aerobic JJ cord-333986-xkx181ek 207 6 exercise exercise NN cord-333986-xkx181ek 207 7 diminished diminish VBD cord-333986-xkx181ek 207 8 the the DT cord-333986-xkx181ek 207 9 decrease decrease NN cord-333986-xkx181ek 207 10 in in IN cord-333986-xkx181ek 207 11 pulmonary pulmonary JJ cord-333986-xkx181ek 207 12 elastin elastin NN cord-333986-xkx181ek 207 13 induced induce VBN cord-333986-xkx181ek 207 14 by by IN cord-333986-xkx181ek 207 15 cigarette cigarette NN cord-333986-xkx181ek 207 16 smoke smoke NN cord-333986-xkx181ek 207 17 exposure exposure NN cord-333986-xkx181ek 207 18 and and CC cord-333986-xkx181ek 207 19 significantly significantly RB cord-333986-xkx181ek 207 20 decreased decrease VBD cord-333986-xkx181ek 207 21 the the DT cord-333986-xkx181ek 207 22 presence presence NN cord-333986-xkx181ek 207 23 of of IN cord-333986-xkx181ek 207 24 reactive reactive JJ cord-333986-xkx181ek 207 25 oxygen oxygen NN cord-333986-xkx181ek 207 26 species specie NNS cord-333986-xkx181ek 207 27 in in IN cord-333986-xkx181ek 207 28 bronchiolar bronchiolar JJ cord-333986-xkx181ek 207 29 lavage lavage NN cord-333986-xkx181ek 207 30 fluid fluid NN cord-333986-xkx181ek 207 31 , , , cord-333986-xkx181ek 207 32 along along IN cord-333986-xkx181ek 207 33 with with IN cord-333986-xkx181ek 207 34 other other JJ cord-333986-xkx181ek 207 35 indicators indicator NNS cord-333986-xkx181ek 207 36 of of IN cord-333986-xkx181ek 207 37 inflammatory inflammatory JJ cord-333986-xkx181ek 207 38 mediated mediate VBN cord-333986-xkx181ek 207 39 damage damage NN cord-333986-xkx181ek 207 40 [ [ -LRB- cord-333986-xkx181ek 207 41 114 114 CD cord-333986-xkx181ek 207 42 ] ] -RRB- cord-333986-xkx181ek 207 43 . . . cord-333986-xkx181ek 208 1 A a DT cord-333986-xkx181ek 208 2 leading leading JJ cord-333986-xkx181ek 208 3 cause cause NN cord-333986-xkx181ek 208 4 of of IN cord-333986-xkx181ek 208 5 death death NN cord-333986-xkx181ek 208 6 in in IN cord-333986-xkx181ek 208 7 patients patient NNS cord-333986-xkx181ek 208 8 with with IN cord-333986-xkx181ek 208 9 COVID-19 COVID-19 NNP cord-333986-xkx181ek 208 10 is be VBZ cord-333986-xkx181ek 208 11 Acute acute JJ cord-333986-xkx181ek 208 12 Respiratory respiratory JJ cord-333986-xkx181ek 208 13 Distress Distress NNP cord-333986-xkx181ek 208 14 Syndrome Syndrome NNP cord-333986-xkx181ek 208 15 ( ( -LRB- cord-333986-xkx181ek 208 16 ARDS ARDS NNP cord-333986-xkx181ek 208 17 ) ) -RRB- cord-333986-xkx181ek 208 18 . . . cord-333986-xkx181ek 209 1 The the DT cord-333986-xkx181ek 209 2 acute acute JJ cord-333986-xkx181ek 209 3 lung lung NN cord-333986-xkx181ek 209 4 injury injury NN cord-333986-xkx181ek 209 5 in in IN cord-333986-xkx181ek 209 6 ARDS ARDS NNP cord-333986-xkx181ek 209 7 results result VBZ cord-333986-xkx181ek 209 8 from from IN cord-333986-xkx181ek 209 9 high high JJ cord-333986-xkx181ek 209 10 levels level NNS cord-333986-xkx181ek 209 11 of of IN cord-333986-xkx181ek 209 12 neutrophil neutrophil NN cord-333986-xkx181ek 209 13 activation activation NN cord-333986-xkx181ek 209 14 and and CC cord-333986-xkx181ek 209 15 accumulation accumulation NN cord-333986-xkx181ek 209 16 of of IN cord-333986-xkx181ek 209 17 reactive reactive JJ cord-333986-xkx181ek 209 18 oxygen oxygen NN cord-333986-xkx181ek 209 19 species specie NNS cord-333986-xkx181ek 209 20 and and CC cord-333986-xkx181ek 209 21 pro pro JJ cord-333986-xkx181ek 209 22 - - JJ cord-333986-xkx181ek 209 23 inflammatory inflammatory JJ cord-333986-xkx181ek 209 24 mediators mediator NNS cord-333986-xkx181ek 209 25 . . . cord-333986-xkx181ek 210 1 Extracellular Extracellular NNP cord-333986-xkx181ek 210 2 Superoxide Superoxide NNP cord-333986-xkx181ek 210 3 Dismutase Dismutase NNP cord-333986-xkx181ek 210 4 ( ( -LRB- cord-333986-xkx181ek 210 5 EcSOD EcSOD NNP cord-333986-xkx181ek 210 6 ) ) -RRB- cord-333986-xkx181ek 210 7 prevents prevent VBZ cord-333986-xkx181ek 210 8 oxidative oxidative JJ cord-333986-xkx181ek 210 9 stress stress NN cord-333986-xkx181ek 210 10 and and CC cord-333986-xkx181ek 210 11 damage damage NN cord-333986-xkx181ek 210 12 through through IN cord-333986-xkx181ek 210 13 extracellular extracellular JJ cord-333986-xkx181ek 210 14 scavenging scavenging NN cord-333986-xkx181ek 210 15 of of IN cord-333986-xkx181ek 210 16 superoxide superoxide NN cord-333986-xkx181ek 210 17 anions anion NNS cord-333986-xkx181ek 210 18 [ [ -LRB- cord-333986-xkx181ek 210 19 115 115 CD cord-333986-xkx181ek 210 20 ] ] -RRB- cord-333986-xkx181ek 210 21 . . . cord-333986-xkx181ek 211 1 Yan Yan NNP cord-333986-xkx181ek 211 2 and and CC cord-333986-xkx181ek 211 3 Spalding Spalding NNP cord-333986-xkx181ek 211 4 described describe VBD cord-333986-xkx181ek 211 5 the the DT cord-333986-xkx181ek 211 6 role role NN cord-333986-xkx181ek 211 7 of of IN cord-333986-xkx181ek 211 8 exercise exercise NN cord-333986-xkx181ek 211 9 in in IN cord-333986-xkx181ek 211 10 increasing increase VBG cord-333986-xkx181ek 211 11 EcSOD EcSOD NNP cord-333986-xkx181ek 211 12 , , , cord-333986-xkx181ek 211 13 initially initially RB cord-333986-xkx181ek 211 14 enhancing enhance VBG cord-333986-xkx181ek 211 15 EcSOD ecsod JJ cord-333986-xkx181ek 211 16 expression expression NN cord-333986-xkx181ek 211 17 in in IN cord-333986-xkx181ek 211 18 skeletal skeletal JJ cord-333986-xkx181ek 211 19 muscle muscle NN cord-333986-xkx181ek 211 20 and and CC cord-333986-xkx181ek 211 21 then then RB cord-333986-xkx181ek 211 22 redistributing redistribute VBG cord-333986-xkx181ek 211 23 to to IN cord-333986-xkx181ek 211 24 lung lung NN cord-333986-xkx181ek 211 25 tissue tissue NN cord-333986-xkx181ek 211 26 . . . cord-333986-xkx181ek 212 1 This this DT cord-333986-xkx181ek 212 2 role role NN cord-333986-xkx181ek 212 3 is be VBZ cord-333986-xkx181ek 212 4 a a DT cord-333986-xkx181ek 212 5 possible possible JJ cord-333986-xkx181ek 212 6 preventative preventative JJ cord-333986-xkx181ek 212 7 or or CC cord-333986-xkx181ek 212 8 therapeutic therapeutic JJ cord-333986-xkx181ek 212 9 option option NN cord-333986-xkx181ek 212 10 for for IN cord-333986-xkx181ek 212 11 reducing reduce VBG cord-333986-xkx181ek 212 12 risk risk NN cord-333986-xkx181ek 212 13 and and CC cord-333986-xkx181ek 212 14 severity severity NN cord-333986-xkx181ek 212 15 of of IN cord-333986-xkx181ek 212 16 ARDS ARDS NNP cord-333986-xkx181ek 212 17 in in IN cord-333986-xkx181ek 212 18 COVID-19 COVID-19 NNP cord-333986-xkx181ek 212 19 [ [ -LRB- cord-333986-xkx181ek 212 20 115 115 CD cord-333986-xkx181ek 212 21 ] ] -RRB- cord-333986-xkx181ek 212 22 . . . cord-333986-xkx181ek 213 1 Increasing increase VBG cord-333986-xkx181ek 213 2 an an DT cord-333986-xkx181ek 213 3 individual individual NN cord-333986-xkx181ek 213 4 's 's POS cord-333986-xkx181ek 213 5 capacity capacity NN cord-333986-xkx181ek 213 6 for for IN cord-333986-xkx181ek 213 7 aerobic aerobic JJ cord-333986-xkx181ek 213 8 exercise exercise NN cord-333986-xkx181ek 213 9 can can MD cord-333986-xkx181ek 213 10 act act VB cord-333986-xkx181ek 213 11 as as IN cord-333986-xkx181ek 213 12 a a DT cord-333986-xkx181ek 213 13 potential potential JJ cord-333986-xkx181ek 213 14 mitigator mitigator NN cord-333986-xkx181ek 213 15 for for IN cord-333986-xkx181ek 213 16 the the DT cord-333986-xkx181ek 213 17 main main JJ cord-333986-xkx181ek 213 18 risk risk NN cord-333986-xkx181ek 213 19 factors factor NNS cord-333986-xkx181ek 213 20 of of IN cord-333986-xkx181ek 213 21 COVID-19 covid-19 NN cord-333986-xkx181ek 213 22 : : : cord-333986-xkx181ek 213 23 aging aging NN cord-333986-xkx181ek 213 24 , , , cord-333986-xkx181ek 213 25 hypertension hypertension NN cord-333986-xkx181ek 213 26 , , , cord-333986-xkx181ek 213 27 diabetes diabetes NN cord-333986-xkx181ek 213 28 , , , cord-333986-xkx181ek 213 29 and and CC cord-333986-xkx181ek 213 30 heart heart NN cord-333986-xkx181ek 213 31 problems problem NNS cord-333986-xkx181ek 213 32 . . . cord-333986-xkx181ek 214 1 Each each DT cord-333986-xkx181ek 214 2 of of IN cord-333986-xkx181ek 214 3 these these DT cord-333986-xkx181ek 214 4 conditions condition NNS cord-333986-xkx181ek 214 5 can can MD cord-333986-xkx181ek 214 6 be be VB cord-333986-xkx181ek 214 7 lessened lessen VBN cord-333986-xkx181ek 214 8 or or CC cord-333986-xkx181ek 214 9 improved improve VBN cord-333986-xkx181ek 214 10 through through IN cord-333986-xkx181ek 214 11 exercise exercise NN cord-333986-xkx181ek 214 12 [ [ -LRB- cord-333986-xkx181ek 214 13 112 112 CD cord-333986-xkx181ek 214 14 , , , cord-333986-xkx181ek 214 15 [ [ -LRB- cord-333986-xkx181ek 214 16 116 116 CD cord-333986-xkx181ek 214 17 ] ] -RRB- cord-333986-xkx181ek 214 18 [ [ -LRB- cord-333986-xkx181ek 214 19 117 117 CD cord-333986-xkx181ek 214 20 ] ] -RRB- cord-333986-xkx181ek 214 21 [ [ -LRB- cord-333986-xkx181ek 214 22 118 118 CD cord-333986-xkx181ek 214 23 ] ] -RRB- cord-333986-xkx181ek 214 24 [ [ -LRB- cord-333986-xkx181ek 214 25 119 119 CD cord-333986-xkx181ek 214 26 ] ] -RRB- cord-333986-xkx181ek 214 27 [ [ -LRB- cord-333986-xkx181ek 214 28 120 120 CD cord-333986-xkx181ek 214 29 ] ] -RRB- cord-333986-xkx181ek 214 30 . . . cord-333986-xkx181ek 215 1 Another another DT cord-333986-xkx181ek 215 2 critical critical JJ cord-333986-xkx181ek 215 3 risk risk NN cord-333986-xkx181ek 215 4 factor factor NN cord-333986-xkx181ek 215 5 in in IN cord-333986-xkx181ek 215 6 determining determine VBG cord-333986-xkx181ek 215 7 health health NN cord-333986-xkx181ek 215 8 factors factor NNS cord-333986-xkx181ek 215 9 for for IN cord-333986-xkx181ek 215 10 COVID-19 COVID-19 NNP cord-333986-xkx181ek 215 11 is be VBZ cord-333986-xkx181ek 215 12 frailty frailty NN cord-333986-xkx181ek 215 13 ; ; : cord-333986-xkx181ek 215 14 a a DT cord-333986-xkx181ek 215 15 marker marker NN cord-333986-xkx181ek 215 16 defined define VBN cord-333986-xkx181ek 215 17 using use VBG cord-333986-xkx181ek 215 18 the the DT cord-333986-xkx181ek 215 19 7-point 7-point NNP cord-333986-xkx181ek 215 20 Clinical Clinical NNP cord-333986-xkx181ek 215 21 Frailty Frailty NNP cord-333986-xkx181ek 215 22 Scale Scale NNP cord-333986-xkx181ek 215 23 [ [ -LRB- cord-333986-xkx181ek 215 24 37 37 CD cord-333986-xkx181ek 215 25 ] ] -RRB- cord-333986-xkx181ek 215 26 . . . cord-333986-xkx181ek 216 1 In in IN cord-333986-xkx181ek 216 2 2019 2019 CD cord-333986-xkx181ek 216 3 , , , cord-333986-xkx181ek 216 4 Hewitt Hewitt NNP cord-333986-xkx181ek 216 5 et et NNP cord-333986-xkx181ek 216 6 al al NNP cord-333986-xkx181ek 216 7 . . NNP cord-333986-xkx181ek 216 8 found find VBD cord-333986-xkx181ek 216 9 that that IN cord-333986-xkx181ek 216 10 worsening worsen VBG cord-333986-xkx181ek 216 11 frailty frailty NN cord-333986-xkx181ek 216 12 , , , cord-333986-xkx181ek 216 13 at at IN cord-333986-xkx181ek 216 14 any any DT cord-333986-xkx181ek 216 15 age age NN cord-333986-xkx181ek 216 16 , , , cord-333986-xkx181ek 216 17 was be VBD cord-333986-xkx181ek 216 18 predictive predictive JJ cord-333986-xkx181ek 216 19 of of IN cord-333986-xkx181ek 216 20 worse bad JJR cord-333986-xkx181ek 216 21 health health NN cord-333986-xkx181ek 216 22 outcomes outcome NNS cord-333986-xkx181ek 216 23 in in IN cord-333986-xkx181ek 216 24 a a DT cord-333986-xkx181ek 216 25 population population NN cord-333986-xkx181ek 216 26 sampled sample VBN cord-333986-xkx181ek 216 27 for for IN cord-333986-xkx181ek 216 28 acute acute JJ cord-333986-xkx181ek 216 29 surgical surgical JJ cord-333986-xkx181ek 216 30 admissions admission NNS cord-333986-xkx181ek 216 31 [ [ -LRB- cord-333986-xkx181ek 216 32 121 121 CD cord-333986-xkx181ek 216 33 ] ] -RRB- cord-333986-xkx181ek 216 34 . . . cord-333986-xkx181ek 217 1 Frailty frailty NN cord-333986-xkx181ek 217 2 has have VBZ cord-333986-xkx181ek 217 3 recently recently RB cord-333986-xkx181ek 217 4 become become VBN cord-333986-xkx181ek 217 5 a a DT cord-333986-xkx181ek 217 6 prognostic prognostic JJ cord-333986-xkx181ek 217 7 marker marker NN cord-333986-xkx181ek 217 8 informing inform VBG cord-333986-xkx181ek 217 9 acute acute JJ cord-333986-xkx181ek 217 10 COVID-19 COVID-19 NNP cord-333986-xkx181ek 217 11 care care NN cord-333986-xkx181ek 217 12 pathway pathway NN cord-333986-xkx181ek 217 13 decisions decision NNS cord-333986-xkx181ek 217 14 amid amid IN cord-333986-xkx181ek 217 15 ventilator ventilator NN cord-333986-xkx181ek 217 16 and and CC cord-333986-xkx181ek 217 17 intensive intensive JJ cord-333986-xkx181ek 217 18 care care NN cord-333986-xkx181ek 217 19 unit unit NN cord-333986-xkx181ek 217 20 bed bed NN cord-333986-xkx181ek 217 21 shortages shortage NNS cord-333986-xkx181ek 217 22 [ [ -LRB- cord-333986-xkx181ek 217 23 37 37 CD cord-333986-xkx181ek 217 24 ] ] -RRB- cord-333986-xkx181ek 217 25 . . . cord-333986-xkx181ek 218 1 Hewitt Hewitt NNP cord-333986-xkx181ek 218 2 et et NNP cord-333986-xkx181ek 218 3 al al NNP cord-333986-xkx181ek 218 4 . . . cord-333986-xkx181ek 219 1 set set VBN cord-333986-xkx181ek 219 2 out out RP cord-333986-xkx181ek 219 3 to to TO cord-333986-xkx181ek 219 4 explore explore VB cord-333986-xkx181ek 219 5 the the DT cord-333986-xkx181ek 219 6 efficacy efficacy NN cord-333986-xkx181ek 219 7 of of IN cord-333986-xkx181ek 219 8 using use VBG cord-333986-xkx181ek 219 9 frailty frailty NN cord-333986-xkx181ek 219 10 in in IN cord-333986-xkx181ek 219 11 this this DT cord-333986-xkx181ek 219 12 context context NN cord-333986-xkx181ek 219 13 , , , cord-333986-xkx181ek 219 14 utilizing utilize VBG cord-333986-xkx181ek 219 15 mortality mortality NN cord-333986-xkx181ek 219 16 and and CC cord-333986-xkx181ek 219 17 length length NN cord-333986-xkx181ek 219 18 of of IN cord-333986-xkx181ek 219 19 stay stay JJ cord-333986-xkx181ek 219 20 data datum NNS cord-333986-xkx181ek 219 21 for for IN cord-333986-xkx181ek 219 22 patients patient NNS cord-333986-xkx181ek 219 23 with with IN cord-333986-xkx181ek 219 24 COVID-19 covid-19 CD cord-333986-xkx181ek 219 25 at at IN cord-333986-xkx181ek 219 26 ten ten CD cord-333986-xkx181ek 219 27 hospitals hospital NNS cord-333986-xkx181ek 219 28 in in IN cord-333986-xkx181ek 219 29 the the DT cord-333986-xkx181ek 219 30 UK UK NNP cord-333986-xkx181ek 219 31 and and CC cord-333986-xkx181ek 219 32 one one CD cord-333986-xkx181ek 219 33 in in IN cord-333986-xkx181ek 219 34 Italy Italy NNP cord-333986-xkx181ek 219 35 [ [ -LRB- cord-333986-xkx181ek 219 36 37 37 CD cord-333986-xkx181ek 219 37 ] ] -RRB- cord-333986-xkx181ek 219 38 . . . cord-333986-xkx181ek 220 1 They -PRON- PRP cord-333986-xkx181ek 220 2 found find VBD cord-333986-xkx181ek 220 3 that that DT cord-333986-xkx181ek 220 4 frailty frailty NN cord-333986-xkx181ek 220 5 was be VBD cord-333986-xkx181ek 220 6 linked link VBN cord-333986-xkx181ek 220 7 both both CC cord-333986-xkx181ek 220 8 to to IN cord-333986-xkx181ek 220 9 earlier early JJR cord-333986-xkx181ek 220 10 deaths death NNS cord-333986-xkx181ek 220 11 and and CC cord-333986-xkx181ek 220 12 more more RBR cord-333986-xkx181ek 220 13 extended extended JJ cord-333986-xkx181ek 220 14 stays stay NNS cord-333986-xkx181ek 220 15 in in IN cord-333986-xkx181ek 220 16 the the DT cord-333986-xkx181ek 220 17 hospital hospital NN cord-333986-xkx181ek 220 18 from from IN cord-333986-xkx181ek 220 19 COVID-19 COVID-19 NNP cord-333986-xkx181ek 220 20 and and CC cord-333986-xkx181ek 220 21 that that IN cord-333986-xkx181ek 220 22 these these DT cord-333986-xkx181ek 220 23 outcomes outcome NNS cord-333986-xkx181ek 220 24 were be VBD cord-333986-xkx181ek 220 25 worse bad JJR cord-333986-xkx181ek 220 26 if if IN cord-333986-xkx181ek 220 27 frailty frailty NN cord-333986-xkx181ek 220 28 increased increase VBD cord-333986-xkx181ek 220 29 , , , cord-333986-xkx181ek 220 30 regardless regardless RB cord-333986-xkx181ek 220 31 of of IN cord-333986-xkx181ek 220 32 age age NN cord-333986-xkx181ek 220 33 or or CC cord-333986-xkx181ek 220 34 other other JJ cord-333986-xkx181ek 220 35 comorbidities comorbiditie NNS cord-333986-xkx181ek 220 36 [ [ -LRB- cord-333986-xkx181ek 220 37 37 37 CD cord-333986-xkx181ek 220 38 ] ] -RRB- cord-333986-xkx181ek 220 39 . . . cord-333986-xkx181ek 221 1 Frailty frailty NN cord-333986-xkx181ek 221 2 can can MD cord-333986-xkx181ek 221 3 also also RB cord-333986-xkx181ek 221 4 be be VB cord-333986-xkx181ek 221 5 present present JJ cord-333986-xkx181ek 221 6 in in IN cord-333986-xkx181ek 221 7 PwP pwp NN cord-333986-xkx181ek 221 8 , , , cord-333986-xkx181ek 221 9 further further RB cord-333986-xkx181ek 221 10 complicating complicate VBG cord-333986-xkx181ek 221 11 the the DT cord-333986-xkx181ek 221 12 clinical clinical JJ cord-333986-xkx181ek 221 13 decisions decision NNS cord-333986-xkx181ek 221 14 for for IN cord-333986-xkx181ek 221 15 these these DT cord-333986-xkx181ek 221 16 patients patient NNS cord-333986-xkx181ek 221 17 [ [ -LRB- cord-333986-xkx181ek 221 18 122 122 CD cord-333986-xkx181ek 221 19 ] ] -RRB- cord-333986-xkx181ek 221 20 . . . cord-333986-xkx181ek 222 1 Importantly importantly RB cord-333986-xkx181ek 222 2 , , , cord-333986-xkx181ek 222 3 exercise exercise NN cord-333986-xkx181ek 222 4 has have VBZ cord-333986-xkx181ek 222 5 been be VBN cord-333986-xkx181ek 222 6 found find VBN cord-333986-xkx181ek 222 7 to to TO cord-333986-xkx181ek 222 8 reduce reduce VB cord-333986-xkx181ek 222 9 frailty frailty NN cord-333986-xkx181ek 222 10 when when WRB cord-333986-xkx181ek 222 11 examined examine VBN cord-333986-xkx181ek 222 12 in in IN cord-333986-xkx181ek 222 13 older old JJR cord-333986-xkx181ek 222 14 adults adult NNS cord-333986-xkx181ek 222 15 who who WP cord-333986-xkx181ek 222 16 had have VBD cord-333986-xkx181ek 222 17 impairments impairment NNS cord-333986-xkx181ek 222 18 in in IN cord-333986-xkx181ek 222 19 physical physical JJ cord-333986-xkx181ek 222 20 performance performance NN cord-333986-xkx181ek 222 21 and and CC cord-333986-xkx181ek 222 22 oxygen oxygen NN cord-333986-xkx181ek 222 23 uptake uptake NN cord-333986-xkx181ek 222 24 [ [ -LRB- cord-333986-xkx181ek 222 25 123 123 CD cord-333986-xkx181ek 222 26 ] ] -RRB- cord-333986-xkx181ek 222 27 [ [ -LRB- cord-333986-xkx181ek 222 28 124 124 CD cord-333986-xkx181ek 222 29 ] ] -RRB- cord-333986-xkx181ek 222 30 [ [ -LRB- cord-333986-xkx181ek 222 31 125 125 CD cord-333986-xkx181ek 222 32 ] ] -RRB- cord-333986-xkx181ek 222 33 [ [ -LRB- cord-333986-xkx181ek 222 34 126 126 CD cord-333986-xkx181ek 222 35 ] ] -RRB- cord-333986-xkx181ek 222 36 . . . cord-333986-xkx181ek 223 1 These these DT cord-333986-xkx181ek 223 2 studies study NNS cord-333986-xkx181ek 223 3 indicate indicate VBP cord-333986-xkx181ek 223 4 that that IN cord-333986-xkx181ek 223 5 frailty frailty NN cord-333986-xkx181ek 223 6 treated treat VBN cord-333986-xkx181ek 223 7 with with IN cord-333986-xkx181ek 223 8 individualized individualized JJ cord-333986-xkx181ek 223 9 exercise exercise NN cord-333986-xkx181ek 223 10 programs program NNS cord-333986-xkx181ek 223 11 that that WDT cord-333986-xkx181ek 223 12 include include VBP cord-333986-xkx181ek 223 13 aerobic aerobic JJ cord-333986-xkx181ek 223 14 exercise exercise NN cord-333986-xkx181ek 223 15 ( ( -LRB- cord-333986-xkx181ek 223 16 low low JJ cord-333986-xkx181ek 223 17 to to IN cord-333986-xkx181ek 223 18 potentially potentially RB cord-333986-xkx181ek 223 19 moderate moderate JJ cord-333986-xkx181ek 223 20 intensity intensity NN cord-333986-xkx181ek 223 21 , , , cord-333986-xkx181ek 223 22 depending depend VBG cord-333986-xkx181ek 223 23 on on IN cord-333986-xkx181ek 223 24 the the DT cord-333986-xkx181ek 223 25 health health NN cord-333986-xkx181ek 223 26 status status NN cord-333986-xkx181ek 223 27 of of IN cord-333986-xkx181ek 223 28 the the DT cord-333986-xkx181ek 223 29 patient patient NN cord-333986-xkx181ek 223 30 ) ) -RRB- cord-333986-xkx181ek 223 31 and and CC cord-333986-xkx181ek 223 32 strength strength NN cord-333986-xkx181ek 223 33 and and CC cord-333986-xkx181ek 223 34 flexibility flexibility NN cord-333986-xkx181ek 223 35 training training NN cord-333986-xkx181ek 223 36 is be VBZ cord-333986-xkx181ek 223 37 most most RBS cord-333986-xkx181ek 223 38 promising promising JJ cord-333986-xkx181ek 223 39 . . . cord-333986-xkx181ek 224 1 These these DT cord-333986-xkx181ek 224 2 results result NNS cord-333986-xkx181ek 224 3 imply imply VBP cord-333986-xkx181ek 224 4 that that IN cord-333986-xkx181ek 224 5 through through IN cord-333986-xkx181ek 224 6 exercise exercise NN cord-333986-xkx181ek 224 7 , , , cord-333986-xkx181ek 224 8 frailty frailty NN cord-333986-xkx181ek 224 9 , , , cord-333986-xkx181ek 224 10 a a DT cord-333986-xkx181ek 224 11 risk risk NN cord-333986-xkx181ek 224 12 factor factor NN cord-333986-xkx181ek 224 13 for for IN cord-333986-xkx181ek 224 14 COVID-19 COVID-19 NNP cord-333986-xkx181ek 224 15 , , , cord-333986-xkx181ek 224 16 could could MD cord-333986-xkx181ek 224 17 potentially potentially RB cord-333986-xkx181ek 224 18 be be VB cord-333986-xkx181ek 224 19 reduced reduce VBN cord-333986-xkx181ek 224 20 with with IN cord-333986-xkx181ek 224 21 improved improve VBN cord-333986-xkx181ek 224 22 physiological physiological JJ cord-333986-xkx181ek 224 23 capacity capacity NN cord-333986-xkx181ek 224 24 ( ( -LRB- cord-333986-xkx181ek 224 25 i.e. i.e. FW cord-333986-xkx181ek 224 26 , , , cord-333986-xkx181ek 224 27 increased increase VBN cord-333986-xkx181ek 224 28 mobility mobility NN cord-333986-xkx181ek 224 29 and and CC cord-333986-xkx181ek 224 30 oxygen oxygen NN cord-333986-xkx181ek 224 31 uptake uptake NN cord-333986-xkx181ek 224 32 ) ) -RRB- cord-333986-xkx181ek 224 33 and and CC cord-333986-xkx181ek 224 34 some some DT cord-333986-xkx181ek 224 35 enhanced enhance VBN cord-333986-xkx181ek 224 36 immunological immunological JJ cord-333986-xkx181ek 224 37 functions function NNS cord-333986-xkx181ek 224 38 . . . cord-333986-xkx181ek 225 1 Exercise exercise NN cord-333986-xkx181ek 225 2 and and CC cord-333986-xkx181ek 225 3 physical physical JJ cord-333986-xkx181ek 225 4 activity activity NN cord-333986-xkx181ek 225 5 improve improve VBP cord-333986-xkx181ek 225 6 the the DT cord-333986-xkx181ek 225 7 health health NN cord-333986-xkx181ek 225 8 of of IN cord-333986-xkx181ek 225 9 the the DT cord-333986-xkx181ek 225 10 aging age VBG cord-333986-xkx181ek 225 11 processes process NNS cord-333986-xkx181ek 225 12 in in IN cord-333986-xkx181ek 225 13 older old JJR cord-333986-xkx181ek 225 14 adults adult NNS cord-333986-xkx181ek 225 15 [ [ -LRB- cord-333986-xkx181ek 225 16 127 127 CD cord-333986-xkx181ek 225 17 ] ] -RRB- cord-333986-xkx181ek 226 1 [ [ -LRB- cord-333986-xkx181ek 226 2 128 128 CD cord-333986-xkx181ek 226 3 ] ] -RRB- cord-333986-xkx181ek 227 1 [ [ -LRB- cord-333986-xkx181ek 227 2 129 129 CD cord-333986-xkx181ek 227 3 ] ] -RRB- cord-333986-xkx181ek 227 4 [ [ -LRB- cord-333986-xkx181ek 227 5 130 130 CD cord-333986-xkx181ek 227 6 ] ] -RRB- cord-333986-xkx181ek 227 7 . . . cord-333986-xkx181ek 228 1 The the DT cord-333986-xkx181ek 228 2 Active Active NNP cord-333986-xkx181ek 228 3 People People NNPS cord-333986-xkx181ek 228 4 , , , cord-333986-xkx181ek 228 5 Healthy Healthy NNP cord-333986-xkx181ek 228 6 Nation Nation NNP cord-333986-xkx181ek 228 7 ™ ™ NN cord-333986-xkx181ek 228 8 recommendation recommendation NN cord-333986-xkx181ek 228 9 is be VBZ cord-333986-xkx181ek 228 10 the the DT cord-333986-xkx181ek 228 11 same same JJ cord-333986-xkx181ek 228 12 for for IN cord-333986-xkx181ek 228 13 adults adult NNS cord-333986-xkx181ek 228 14 ( ( -LRB- cord-333986-xkx181ek 228 15 ages age NNS cord-333986-xkx181ek 228 16 18 18 CD cord-333986-xkx181ek 228 17 - - SYM cord-333986-xkx181ek 228 18 64 64 CD cord-333986-xkx181ek 228 19 ) ) -RRB- cord-333986-xkx181ek 228 20 and and CC cord-333986-xkx181ek 228 21 older old JJR cord-333986-xkx181ek 228 22 adults adult NNS cord-333986-xkx181ek 228 23 ( ( -LRB- cord-333986-xkx181ek 228 24 65 65 CD cord-333986-xkx181ek 228 25 years year NNS cord-333986-xkx181ek 228 26 and and CC cord-333986-xkx181ek 228 27 older old JJR cord-333986-xkx181ek 228 28 ) ) -RRB- cord-333986-xkx181ek 228 29 for for IN cord-333986-xkx181ek 228 30 substantial substantial JJ cord-333986-xkx181ek 228 31 health health NN cord-333986-xkx181ek 228 32 benefits benefit NNS cord-333986-xkx181ek 228 33 . . . cord-333986-xkx181ek 229 1 The the DT cord-333986-xkx181ek 229 2 recommendation recommendation NN cord-333986-xkx181ek 229 3 includes include VBZ cord-333986-xkx181ek 229 4 150 150 CD cord-333986-xkx181ek 229 5 to to TO cord-333986-xkx181ek 229 6 300 300 CD cord-333986-xkx181ek 229 7 min min NN cord-333986-xkx181ek 229 8 per per IN cord-333986-xkx181ek 229 9 week week NN cord-333986-xkx181ek 229 10 of of IN cord-333986-xkx181ek 229 11 moderate moderate JJ cord-333986-xkx181ek 229 12 - - HYPH cord-333986-xkx181ek 229 13 intensity intensity NN cord-333986-xkx181ek 229 14 exercise exercise NN cord-333986-xkx181ek 229 15 , , , cord-333986-xkx181ek 229 16 or or CC cord-333986-xkx181ek 229 17 75 75 CD cord-333986-xkx181ek 229 18 min min NN cord-333986-xkx181ek 229 19 to to IN cord-333986-xkx181ek 229 20 150 150 CD cord-333986-xkx181ek 229 21 min min NN cord-333986-xkx181ek 229 22 a a DT cord-333986-xkx181ek 229 23 week week NN cord-333986-xkx181ek 229 24 of of IN cord-333986-xkx181ek 229 25 high high JJ cord-333986-xkx181ek 229 26 - - HYPH cord-333986-xkx181ek 229 27 intensity intensity NN cord-333986-xkx181ek 229 28 aerobic aerobic JJ cord-333986-xkx181ek 229 29 activity activity NN cord-333986-xkx181ek 229 30 , , , cord-333986-xkx181ek 229 31 or or CC cord-333986-xkx181ek 229 32 some some DT cord-333986-xkx181ek 229 33 combination combination NN cord-333986-xkx181ek 229 34 of of IN cord-333986-xkx181ek 229 35 moderate moderate JJ cord-333986-xkx181ek 229 36 - - HYPH cord-333986-xkx181ek 229 37 and and CC cord-333986-xkx181ek 229 38 high high JJ cord-333986-xkx181ek 229 39 - - HYPH cord-333986-xkx181ek 229 40 intensity intensity NN cord-333986-xkx181ek 229 41 aerobic aerobic JJ cord-333986-xkx181ek 229 42 activity activity NN cord-333986-xkx181ek 229 43 [ [ -LRB- cord-333986-xkx181ek 229 44 44 44 CD cord-333986-xkx181ek 229 45 ] ] -RRB- cord-333986-xkx181ek 229 46 . . . cord-333986-xkx181ek 230 1 The the DT cord-333986-xkx181ek 230 2 recommendation recommendation NN cord-333986-xkx181ek 230 3 also also RB cord-333986-xkx181ek 230 4 includes include VBZ cord-333986-xkx181ek 230 5 at at IN cord-333986-xkx181ek 230 6 least least RBS cord-333986-xkx181ek 230 7 two two CD cord-333986-xkx181ek 230 8 days day NNS cord-333986-xkx181ek 230 9 / / SYM cord-333986-xkx181ek 230 10 week week NN cord-333986-xkx181ek 230 11 of of IN cord-333986-xkx181ek 230 12 muscle muscle NN cord-333986-xkx181ek 230 13 - - HYPH cord-333986-xkx181ek 230 14 strengthening strengthen VBG cord-333986-xkx181ek 230 15 action action NN cord-333986-xkx181ek 230 16 [ [ -LRB- cord-333986-xkx181ek 230 17 44 44 CD cord-333986-xkx181ek 230 18 ] ] -RRB- cord-333986-xkx181ek 230 19 . . . cord-333986-xkx181ek 231 1 Activities activity NNS cord-333986-xkx181ek 231 2 that that WDT cord-333986-xkx181ek 231 3 improve improve VBP cord-333986-xkx181ek 231 4 balance balance NN cord-333986-xkx181ek 231 5 for for IN cord-333986-xkx181ek 231 6 older old JJR cord-333986-xkx181ek 231 7 adults adult NNS cord-333986-xkx181ek 231 8 , , , cord-333986-xkx181ek 231 9 such such JJ cord-333986-xkx181ek 231 10 as as IN cord-333986-xkx181ek 231 11 standing stand VBG cord-333986-xkx181ek 231 12 on on IN cord-333986-xkx181ek 231 13 one one CD cord-333986-xkx181ek 231 14 foot foot NN cord-333986-xkx181ek 231 15 , , , cord-333986-xkx181ek 231 16 is be VBZ cord-333986-xkx181ek 231 17 also also RB cord-333986-xkx181ek 231 18 encouraged encourage VBN cord-333986-xkx181ek 231 19 [ [ -LRB- cord-333986-xkx181ek 231 20 44 44 CD cord-333986-xkx181ek 231 21 ] ] -RRB- cord-333986-xkx181ek 231 22 . . . cord-333986-xkx181ek 232 1 Regular regular JJ cord-333986-xkx181ek 232 2 physical physical JJ cord-333986-xkx181ek 232 3 exercise exercise NN cord-333986-xkx181ek 232 4 has have VBZ cord-333986-xkx181ek 232 5 numerous numerous JJ cord-333986-xkx181ek 232 6 beneficial beneficial JJ cord-333986-xkx181ek 232 7 health health NN cord-333986-xkx181ek 232 8 effects effect NNS cord-333986-xkx181ek 232 9 in in IN cord-333986-xkx181ek 232 10 PD PD NNP cord-333986-xkx181ek 232 11 , , , cord-333986-xkx181ek 232 12 including include VBG cord-333986-xkx181ek 232 13 the the DT cord-333986-xkx181ek 232 14 impact impact NN cord-333986-xkx181ek 232 15 on on IN cord-333986-xkx181ek 232 16 the the DT cord-333986-xkx181ek 232 17 immune immune JJ cord-333986-xkx181ek 232 18 system system NN cord-333986-xkx181ek 232 19 and and CC cord-333986-xkx181ek 232 20 the the DT cord-333986-xkx181ek 232 21 potential potential NN cord-333986-xkx181ek 232 22 to to TO cord-333986-xkx181ek 232 23 reduce reduce VB cord-333986-xkx181ek 232 24 neuroinflammation neuroinflammation NN cord-333986-xkx181ek 232 25 ( ( -LRB- cord-333986-xkx181ek 232 26 which which WDT cord-333986-xkx181ek 232 27 would would MD cord-333986-xkx181ek 232 28 be be VB cord-333986-xkx181ek 232 29 neuroprotective neuroprotective JJ cord-333986-xkx181ek 232 30 ) ) -RRB- cord-333986-xkx181ek 232 31 and and CC cord-333986-xkx181ek 232 32 promote promote VB cord-333986-xkx181ek 232 33 neuroplasticity neuroplasticity NN cord-333986-xkx181ek 232 34 . . . cord-333986-xkx181ek 233 1 Persistent persistent JJ cord-333986-xkx181ek 233 2 moderate moderate JJ cord-333986-xkx181ek 233 3 - - HYPH cord-333986-xkx181ek 233 4 intensity intensity NN cord-333986-xkx181ek 233 5 exercise exercise NN cord-333986-xkx181ek 233 6 by by IN cord-333986-xkx181ek 233 7 PwP PwP NNP cord-333986-xkx181ek 233 8 is be VBZ cord-333986-xkx181ek 233 9 a a DT cord-333986-xkx181ek 233 10 treatment treatment NN cord-333986-xkx181ek 233 11 strategy strategy NN cord-333986-xkx181ek 233 12 to to TO cord-333986-xkx181ek 233 13 improve improve VB cord-333986-xkx181ek 233 14 the the DT cord-333986-xkx181ek 233 15 QoL qol NN cord-333986-xkx181ek 233 16 and and CC cord-333986-xkx181ek 233 17 likely likely RB cord-333986-xkx181ek 233 18 reduce reduce VB cord-333986-xkx181ek 233 19 neuroinflammation neuroinflammation NN cord-333986-xkx181ek 233 20 . . . cord-333986-xkx181ek 234 1 Using use VBG cord-333986-xkx181ek 234 2 more more RBR cord-333986-xkx181ek 234 3 demanding demanding JJ cord-333986-xkx181ek 234 4 moderateto moderateto JJ cord-333986-xkx181ek 234 5 high high JJ cord-333986-xkx181ek 234 6 - - HYPH cord-333986-xkx181ek 234 7 intensity intensity NN cord-333986-xkx181ek 234 8 exercise exercise NN cord-333986-xkx181ek 234 9 programs program NNS cord-333986-xkx181ek 234 10 ( ( -LRB- cord-333986-xkx181ek 234 11 examples example NNS cord-333986-xkx181ek 234 12 include include VBP cord-333986-xkx181ek 234 13 PWR!Moves pwr!move NNS cord-333986-xkx181ek 234 14 , , , cord-333986-xkx181ek 234 15 Rock Rock NNP cord-333986-xkx181ek 234 16 Steady Steady NNP cord-333986-xkx181ek 234 17 Boxing Boxing NNP cord-333986-xkx181ek 234 18 , , , cord-333986-xkx181ek 234 19 Dance Dance NNP cord-333986-xkx181ek 234 20 for for IN cord-333986-xkx181ek 234 21 PD PD NNP cord-333986-xkx181ek 234 22 , , , cord-333986-xkx181ek 234 23 stationary stationary JJ cord-333986-xkx181ek 234 24 bike bike NN cord-333986-xkx181ek 234 25 , , , cord-333986-xkx181ek 234 26 and and CC cord-333986-xkx181ek 234 27 power power NN cord-333986-xkx181ek 234 28 - - HYPH cord-333986-xkx181ek 234 29 walking walk VBG cord-333986-xkx181ek 234 30 with with IN cord-333986-xkx181ek 234 31 walking walk VBG cord-333986-xkx181ek 234 32 poles pole NNS cord-333986-xkx181ek 234 33 ) ) -RRB- cord-333986-xkx181ek 234 34 [ [ -LRB- cord-333986-xkx181ek 234 35 10 10 CD cord-333986-xkx181ek 234 36 , , , cord-333986-xkx181ek 234 37 87 87 CD cord-333986-xkx181ek 234 38 , , , cord-333986-xkx181ek 234 39 88 88 CD cord-333986-xkx181ek 234 40 , , , cord-333986-xkx181ek 234 41 [ [ -LRB- cord-333986-xkx181ek 234 42 90 90 CD cord-333986-xkx181ek 234 43 ] ] -RRB- cord-333986-xkx181ek 234 44 [ [ -LRB- cord-333986-xkx181ek 234 45 91 91 CD cord-333986-xkx181ek 234 46 ] ] -RRB- cord-333986-xkx181ek 234 47 [ [ -LRB- cord-333986-xkx181ek 234 48 92 92 CD cord-333986-xkx181ek 234 49 ] ] -RRB- cord-333986-xkx181ek 234 50 101 101 CD cord-333986-xkx181ek 234 51 , , , cord-333986-xkx181ek 234 52 [ [ -LRB- cord-333986-xkx181ek 234 53 103 103 CD cord-333986-xkx181ek 234 54 ] ] -RRB- cord-333986-xkx181ek 234 55 [ [ -LRB- cord-333986-xkx181ek 234 56 104 104 CD cord-333986-xkx181ek 234 57 ] ] -RRB- cord-333986-xkx181ek 234 58 [ [ -LRB- cord-333986-xkx181ek 234 59 105 105 CD cord-333986-xkx181ek 234 60 ] ] -RRB- cord-333986-xkx181ek 234 61 [ [ -LRB- cord-333986-xkx181ek 234 62 106 106 CD cord-333986-xkx181ek 234 63 ] ] -RRB- cord-333986-xkx181ek 234 64 109 109 CD cord-333986-xkx181ek 234 65 ] ] -RRB- cord-333986-xkx181ek 234 66 , , , cord-333986-xkx181ek 234 67 with with IN cord-333986-xkx181ek 234 68 sustained sustained JJ cord-333986-xkx181ek 234 69 use use NN cord-333986-xkx181ek 234 70 , , , cord-333986-xkx181ek 234 71 could could MD cord-333986-xkx181ek 234 72 eventually eventually RB cord-333986-xkx181ek 234 73 promote promote VB cord-333986-xkx181ek 234 74 neuroplasticity neuroplasticity NN cord-333986-xkx181ek 234 75 in in IN cord-333986-xkx181ek 234 76 PwP. PwP. NNP cord-333986-xkx181ek 235 1 Finally finally RB cord-333986-xkx181ek 235 2 , , , cord-333986-xkx181ek 235 3 research research NN cord-333986-xkx181ek 235 4 has have VBZ cord-333986-xkx181ek 235 5 shown show VBN cord-333986-xkx181ek 235 6 that that IN cord-333986-xkx181ek 235 7 the the DT cord-333986-xkx181ek 235 8 immune immune JJ cord-333986-xkx181ek 235 9 response response NN cord-333986-xkx181ek 235 10 is be VBZ cord-333986-xkx181ek 235 11 strengthened strengthen VBN cord-333986-xkx181ek 235 12 from from IN cord-333986-xkx181ek 235 13 moderate moderate JJ cord-333986-xkx181ek 235 14 - - HYPH cord-333986-xkx181ek 235 15 intensity intensity NN cord-333986-xkx181ek 235 16 exercise exercise NN cord-333986-xkx181ek 235 17 . . . cord-333986-xkx181ek 236 1 Thus thus RB cord-333986-xkx181ek 236 2 , , , cord-333986-xkx181ek 236 3 exercise exercise NN cord-333986-xkx181ek 236 4 may may MD cord-333986-xkx181ek 236 5 provide provide VB cord-333986-xkx181ek 236 6 a a DT cord-333986-xkx181ek 236 7 nonpharmacological nonpharmacological JJ cord-333986-xkx181ek 236 8 strategy strategy NN cord-333986-xkx181ek 236 9 if if IN cord-333986-xkx181ek 236 10 COVID-19 COVID-19 NNP cord-333986-xkx181ek 236 11 infects infect VBZ cord-333986-xkx181ek 236 12 one one CD cord-333986-xkx181ek 236 13 or or CC cord-333986-xkx181ek 236 14 if if IN cord-333986-xkx181ek 236 15 one one PRP cord-333986-xkx181ek 236 16 wants want VBZ cord-333986-xkx181ek 236 17 to to TO cord-333986-xkx181ek 236 18 protect protect VB cord-333986-xkx181ek 236 19 themselves -PRON- PRP cord-333986-xkx181ek 236 20 from from IN cord-333986-xkx181ek 236 21 infection infection NN cord-333986-xkx181ek 236 22 [ [ -LRB- cord-333986-xkx181ek 236 23 31 31 CD cord-333986-xkx181ek 236 24 ] ] -RRB- cord-333986-xkx181ek 236 25 . . . cord-333986-xkx181ek 237 1 Older old JJR cord-333986-xkx181ek 237 2 adults adult NNS cord-333986-xkx181ek 237 3 , , , cord-333986-xkx181ek 237 4 with with IN cord-333986-xkx181ek 237 5 or or CC cord-333986-xkx181ek 237 6 without without IN cord-333986-xkx181ek 237 7 PD PD NNP cord-333986-xkx181ek 237 8 , , , cord-333986-xkx181ek 237 9 are be VBP cord-333986-xkx181ek 237 10 more more RBR cord-333986-xkx181ek 237 11 susceptible susceptible JJ cord-333986-xkx181ek 237 12 to to IN cord-333986-xkx181ek 237 13 SARS SARS NNP cord-333986-xkx181ek 237 14 - - HYPH cord-333986-xkx181ek 237 15 CoV-2 CoV-2 NNP cord-333986-xkx181ek 237 16 viral viral JJ cord-333986-xkx181ek 237 17 infection infection NN cord-333986-xkx181ek 237 18 , , , cord-333986-xkx181ek 237 19 and and CC cord-333986-xkx181ek 237 20 moderate moderate JJ cord-333986-xkx181ek 237 21 exercise exercise NN cord-333986-xkx181ek 237 22 may may MD cord-333986-xkx181ek 237 23 help help VB cord-333986-xkx181ek 237 24 to to TO cord-333986-xkx181ek 237 25 improve improve VB cord-333986-xkx181ek 237 26 the the DT cord-333986-xkx181ek 237 27 immune immune JJ cord-333986-xkx181ek 237 28 response response NN cord-333986-xkx181ek 237 29 to to IN cord-333986-xkx181ek 237 30 COVID-19 covid-19 JJ cord-333986-xkx181ek 237 31 infection infection NN cord-333986-xkx181ek 237 32 . . . cord-333986-xkx181ek 238 1 Moderate moderate JJ cord-333986-xkx181ek 238 2 - - HYPH cord-333986-xkx181ek 238 3 intensity intensity NN cord-333986-xkx181ek 238 4 exercise exercise NN cord-333986-xkx181ek 238 5 may may MD cord-333986-xkx181ek 238 6 also also RB cord-333986-xkx181ek 238 7 help help VB cord-333986-xkx181ek 238 8 boost boost VB cord-333986-xkx181ek 238 9 the the DT cord-333986-xkx181ek 238 10 immune immune JJ cord-333986-xkx181ek 238 11 system system NN cord-333986-xkx181ek 238 12 response response NN cord-333986-xkx181ek 238 13 to to IN cord-333986-xkx181ek 238 14 the the DT cord-333986-xkx181ek 238 15 COVID-19 COVID-19 NNP cord-333986-xkx181ek 238 16 vaccination vaccination NN cord-333986-xkx181ek 238 17 when when WRB cord-333986-xkx181ek 238 18 it -PRON- PRP cord-333986-xkx181ek 238 19 becomes become VBZ cord-333986-xkx181ek 238 20 available available JJ cord-333986-xkx181ek 238 21 . . . cord-333986-xkx181ek 238 22 _SP cord-333986-xkx181ek 239 1 Parkinson Parkinson NNP cord-333986-xkx181ek 239 2 's 's POS cord-333986-xkx181ek 239 3 disease disease NN cord-333986-xkx181ek 240 1 The the DT cord-333986-xkx181ek 240 2 New New NNP cord-333986-xkx181ek 240 3 Parkinson Parkinson NNP cord-333986-xkx181ek 240 4 's 's POS cord-333986-xkx181ek 240 5 Disease Disease NNP cord-333986-xkx181ek 240 6 Treatment Treatment NNP cord-333986-xkx181ek 240 7 Book Book NNP cord-333986-xkx181ek 240 8 : : : cord-333986-xkx181ek 241 1 Partnering partner VBG cord-333986-xkx181ek 241 2 with with IN cord-333986-xkx181ek 241 3 Your -PRON- PRP$ cord-333986-xkx181ek 241 4 Doctor doctor NN cord-333986-xkx181ek 241 5 to to TO cord-333986-xkx181ek 241 6 Get get VB cord-333986-xkx181ek 241 7 the the DT cord-333986-xkx181ek 241 8 Most Most JJS cord-333986-xkx181ek 241 9 from from IN cord-333986-xkx181ek 241 10 Your -PRON- PRP$ cord-333986-xkx181ek 241 11 Medications Medications NNP cord-333986-xkx181ek 241 12 Motor Motor NNP cord-333986-xkx181ek 241 13 and and CC cord-333986-xkx181ek 241 14 non non JJ cord-333986-xkx181ek 241 15 - - JJ cord-333986-xkx181ek 241 16 motor motor JJ cord-333986-xkx181ek 241 17 symptoms symptom NNS cord-333986-xkx181ek 241 18 of of IN cord-333986-xkx181ek 241 19 Parkinson Parkinson NNP cord-333986-xkx181ek 241 20 's 's POS cord-333986-xkx181ek 241 21 disease disease NN cord-333986-xkx181ek 241 22 and and CC cord-333986-xkx181ek 241 23 their -PRON- PRP$ cord-333986-xkx181ek 241 24 impact impact NN cord-333986-xkx181ek 241 25 on on IN cord-333986-xkx181ek 241 26 quality quality NN cord-333986-xkx181ek 241 27 of of IN cord-333986-xkx181ek 241 28 life life NN cord-333986-xkx181ek 241 29 and and CC cord-333986-xkx181ek 241 30 on on IN cord-333986-xkx181ek 241 31 different different JJ cord-333986-xkx181ek 241 32 clinical clinical JJ cord-333986-xkx181ek 241 33 subgroups subgroup NNS cord-333986-xkx181ek 241 34 Non non JJ cord-333986-xkx181ek 241 35 - - JJ cord-333986-xkx181ek 241 36 motor motor JJ cord-333986-xkx181ek 241 37 symptoms symptom NNS cord-333986-xkx181ek 241 38 in in IN cord-333986-xkx181ek 241 39 early early JJ cord-333986-xkx181ek 241 40 Parkinson Parkinson NNP cord-333986-xkx181ek 241 41 's 's POS cord-333986-xkx181ek 241 42 disease disease NN cord-333986-xkx181ek 241 43 with with IN cord-333986-xkx181ek 241 44 different different JJ cord-333986-xkx181ek 241 45 motor motor NN cord-333986-xkx181ek 241 46 subtypes subtype NNS cord-333986-xkx181ek 241 47 and and CC cord-333986-xkx181ek 241 48 their -PRON- PRP$ cord-333986-xkx181ek 241 49 associations association NNS cord-333986-xkx181ek 241 50 with with IN cord-333986-xkx181ek 241 51 quality quality NN cord-333986-xkx181ek 241 52 of of IN cord-333986-xkx181ek 241 53 life life NN cord-333986-xkx181ek 241 54 Synergy Synergy NNP cord-333986-xkx181ek 241 55 between between IN cord-333986-xkx181ek 241 56 plasminogen plasminogen NN cord-333986-xkx181ek 241 57 activator activator NN cord-333986-xkx181ek 241 58 inhibitor-1 inhibitor-1 NNP cord-333986-xkx181ek 241 59 , , , cord-333986-xkx181ek 241 60 α α NNP cord-333986-xkx181ek 241 61 - - HYPH cord-333986-xkx181ek 241 62 synuclein synuclein NNP cord-333986-xkx181ek 241 63 , , , cord-333986-xkx181ek 241 64 and and CC cord-333986-xkx181ek 241 65 neuroinflammation neuroinflammation NN cord-333986-xkx181ek 241 66 in in IN cord-333986-xkx181ek 241 67 Parkinson Parkinson NNP cord-333986-xkx181ek 241 68 's 's POS cord-333986-xkx181ek 241 69 disease disease NN cord-333986-xkx181ek 241 70 Pharmacological pharmacological JJ cord-333986-xkx181ek 241 71 treatment treatment NN cord-333986-xkx181ek 241 72 of of IN cord-333986-xkx181ek 241 73 Parkinson Parkinson NNP cord-333986-xkx181ek 241 74 disease disease NN cord-333986-xkx181ek 241 75 : : : cord-333986-xkx181ek 241 76 A a DT cord-333986-xkx181ek 241 77 review review NN cord-333986-xkx181ek 241 78 Diagnosis diagnosis NN cord-333986-xkx181ek 241 79 and and CC cord-333986-xkx181ek 241 80 treatment treatment NN cord-333986-xkx181ek 241 81 of of IN cord-333986-xkx181ek 241 82 Parkinson Parkinson NNP cord-333986-xkx181ek 241 83 disease disease NN cord-333986-xkx181ek 241 84 : : : cord-333986-xkx181ek 241 85 A a DT cord-333986-xkx181ek 241 86 review review NN cord-333986-xkx181ek 241 87 Integrative Integrative NNP cord-333986-xkx181ek 241 88 Medicine Medicine NNP cord-333986-xkx181ek 241 89 and and CC cord-333986-xkx181ek 241 90 Health Health NNP cord-333986-xkx181ek 241 91 Therapy Therapy NNP cord-333986-xkx181ek 241 92 for for IN cord-333986-xkx181ek 241 93 Parkinson Parkinson NNP cord-333986-xkx181ek 241 94 Disease Disease NNP cord-333986-xkx181ek 241 95 Exercise Exercise NNP cord-333986-xkx181ek 241 96 - - HYPH cord-333986-xkx181ek 241 97 enhanced enhance VBN cord-333986-xkx181ek 241 98 neuroplasticity neuroplasticity NN cord-333986-xkx181ek 241 99 targeting target VBG cord-333986-xkx181ek 241 100 motor motor NN cord-333986-xkx181ek 241 101 and and CC cord-333986-xkx181ek 241 102 cognitive cognitive JJ cord-333986-xkx181ek 241 103 circuitry circuitry NN cord-333986-xkx181ek 241 104 in in IN cord-333986-xkx181ek 241 105 Parkinson Parkinson NNP cord-333986-xkx181ek 241 106 's 's POS cord-333986-xkx181ek 241 107 disease disease NN cord-333986-xkx181ek 241 108 Exercise exercise NN cord-333986-xkx181ek 241 109 and and CC cord-333986-xkx181ek 241 110 neuroplasticity neuroplasticity NN cord-333986-xkx181ek 241 111 in in IN cord-333986-xkx181ek 241 112 persons person NNS cord-333986-xkx181ek 241 113 living live VBG cord-333986-xkx181ek 241 114 with with IN cord-333986-xkx181ek 241 115 Parkinson Parkinson NNP cord-333986-xkx181ek 241 116 's 's POS cord-333986-xkx181ek 241 117 disease disease NN cord-333986-xkx181ek 242 1 How how WRB cord-333986-xkx181ek 242 2 might may MD cord-333986-xkx181ek 242 3 physical physical JJ cord-333986-xkx181ek 242 4 activity activity NN cord-333986-xkx181ek 242 5 benefit benefit NN cord-333986-xkx181ek 242 6 patients patient NNS cord-333986-xkx181ek 242 7 with with IN cord-333986-xkx181ek 242 8 Parkinson Parkinson NNP cord-333986-xkx181ek 242 9 disease disease NN cord-333986-xkx181ek 242 10 ? ? . cord-333986-xkx181ek 243 1 Science Science NNP cord-333986-xkx181ek 243 2 Forum Forum NNP cord-333986-xkx181ek 243 3 : : : cord-333986-xkx181ek 243 4 SARS SARS NNP cord-333986-xkx181ek 243 5 - - HYPH cord-333986-xkx181ek 243 6 CoV-2 CoV-2 NNP cord-333986-xkx181ek 243 7 ( ( -LRB- cord-333986-xkx181ek 243 8 COVID-19 covid-19 VB cord-333986-xkx181ek 243 9 ) ) -RRB- cord-333986-xkx181ek 243 10 by by IN cord-333986-xkx181ek 243 11 the the DT cord-333986-xkx181ek 243 12 numbers number NNS cord-333986-xkx181ek 243 13 Review Review NNP cord-333986-xkx181ek 243 14 of of IN cord-333986-xkx181ek 243 15 the the DT cord-333986-xkx181ek 243 16 clinical clinical JJ cord-333986-xkx181ek 243 17 characteristics characteristic NNS cord-333986-xkx181ek 243 18 of of IN cord-333986-xkx181ek 243 19 coronavirus coronavirus NN cord-333986-xkx181ek 243 20 disease disease NN cord-333986-xkx181ek 243 21 2019 2019 CD cord-333986-xkx181ek 243 22 ( ( -LRB- cord-333986-xkx181ek 243 23 COVID-19 COVID-19 NNP cord-333986-xkx181ek 243 24 ) ) -RRB- cord-333986-xkx181ek 244 1 The the DT cord-333986-xkx181ek 244 2 trinity trinity NN cord-333986-xkx181ek 244 3 of of IN cord-333986-xkx181ek 244 4 COVID-19 COVID-19 NNP cord-333986-xkx181ek 244 5 : : : cord-333986-xkx181ek 244 6 Immunity immunity NN cord-333986-xkx181ek 244 7 , , , cord-333986-xkx181ek 244 8 inflammation inflammation NN cord-333986-xkx181ek 244 9 and and CC cord-333986-xkx181ek 244 10 intervention intervention NN cord-333986-xkx181ek 244 11 Understanding understanding NN cord-333986-xkx181ek 244 12 of of IN cord-333986-xkx181ek 244 13 COVID-19 COVID-19 NNP cord-333986-xkx181ek 244 14 based base VBN cord-333986-xkx181ek 244 15 on on IN cord-333986-xkx181ek 244 16 current current JJ cord-333986-xkx181ek 244 17 evidence evidence NN cord-333986-xkx181ek 244 18 Clinical clinical JJ cord-333986-xkx181ek 244 19 characteristics characteristic NNS cord-333986-xkx181ek 244 20 and and CC cord-333986-xkx181ek 244 21 intrauterine intrauterine JJ cord-333986-xkx181ek 244 22 vertical vertical JJ cord-333986-xkx181ek 244 23 transmission transmission NN cord-333986-xkx181ek 244 24 potential potential NN cord-333986-xkx181ek 244 25 of of IN cord-333986-xkx181ek 244 26 COVID-19 covid-19 JJ cord-333986-xkx181ek 244 27 infection infection NN cord-333986-xkx181ek 244 28 in in IN cord-333986-xkx181ek 244 29 nine nine CD cord-333986-xkx181ek 244 30 pregnant pregnant JJ cord-333986-xkx181ek 244 31 women woman NNS cord-333986-xkx181ek 244 32 : : : cord-333986-xkx181ek 244 33 A a DT cord-333986-xkx181ek 244 34 retrospective retrospective JJ cord-333986-xkx181ek 244 35 review review NN cord-333986-xkx181ek 244 36 of of IN cord-333986-xkx181ek 244 37 medical medical JJ cord-333986-xkx181ek 244 38 records record NNS cord-333986-xkx181ek 244 39 COVID-19 covid-19 VBP cord-333986-xkx181ek 244 40 illness illness NN cord-333986-xkx181ek 244 41 in in IN cord-333986-xkx181ek 244 42 native native JJ cord-333986-xkx181ek 244 43 and and CC cord-333986-xkx181ek 244 44 immunosuppressed immunosuppressed JJ cord-333986-xkx181ek 244 45 states state NNS cord-333986-xkx181ek 244 46 : : : cord-333986-xkx181ek 244 47 A a DT cord-333986-xkx181ek 244 48 clinical clinical JJ cord-333986-xkx181ek 244 49 - - HYPH cord-333986-xkx181ek 244 50 therapeutic therapeutic JJ cord-333986-xkx181ek 244 51 staging staging NN cord-333986-xkx181ek 244 52 proposal proposal NN cord-333986-xkx181ek 244 53 Making make VBG cord-333986-xkx181ek 244 54 sense sense NN cord-333986-xkx181ek 244 55 of of IN cord-333986-xkx181ek 244 56 the the DT cord-333986-xkx181ek 244 57 cytokine cytokine NN cord-333986-xkx181ek 244 58 storm storm NN cord-333986-xkx181ek 244 59 : : : cord-333986-xkx181ek 244 60 A a DT cord-333986-xkx181ek 244 61 conceptual conceptual JJ cord-333986-xkx181ek 244 62 framework framework NN cord-333986-xkx181ek 244 63 for for IN cord-333986-xkx181ek 244 64 understanding understanding NN cord-333986-xkx181ek 244 65 , , , cord-333986-xkx181ek 244 66 diagnosing diagnose VBG cord-333986-xkx181ek 244 67 , , , cord-333986-xkx181ek 244 68 and and CC cord-333986-xkx181ek 244 69 treating treat VBG cord-333986-xkx181ek 244 70 hemophagocytic hemophagocytic JJ cord-333986-xkx181ek 244 71 syndromes syndrome NNS cord-333986-xkx181ek 244 72 . . . cord-333986-xkx181ek 245 1 Pediatric pediatric JJ cord-333986-xkx181ek 245 2 Clin Clin NNP cord-333986-xkx181ek 246 1 On on IN cord-333986-xkx181ek 246 2 the the DT cord-333986-xkx181ek 246 3 alert alert NN cord-333986-xkx181ek 246 4 for for IN cord-333986-xkx181ek 246 5 cytokine cytokine JJ cord-333986-xkx181ek 246 6 storm storm NN cord-333986-xkx181ek 246 7 : : : cord-333986-xkx181ek 246 8 Immunopathology immunopathology NN cord-333986-xkx181ek 246 9 in in IN cord-333986-xkx181ek 246 10 COVID-19 COVID-19 NNP cord-333986-xkx181ek 246 11 COVID-19-New COVID-19-New NNP cord-333986-xkx181ek 246 12 insights insight NNS cord-333986-xkx181ek 246 13 on on IN cord-333986-xkx181ek 246 14 a a DT cord-333986-xkx181ek 246 15 rapidly rapidly RB cord-333986-xkx181ek 246 16 changing change VBG cord-333986-xkx181ek 246 17 epidemic epidemic NN cord-333986-xkx181ek 246 18 How how WRB cord-333986-xkx181ek 246 19 will will MD cord-333986-xkx181ek 246 20 country country NN cord-333986-xkx181ek 246 21 - - HYPH cord-333986-xkx181ek 246 22 based base VBN cord-333986-xkx181ek 246 23 mitigation mitigation NN cord-333986-xkx181ek 246 24 measures measure NNS cord-333986-xkx181ek 246 25 influence influence VBP cord-333986-xkx181ek 246 26 the the DT cord-333986-xkx181ek 246 27 course course NN cord-333986-xkx181ek 246 28 of of IN cord-333986-xkx181ek 246 29 the the DT cord-333986-xkx181ek 246 30 COVID-19 covid-19 JJ cord-333986-xkx181ek 246 31 epidemic epidemic NN cord-333986-xkx181ek 246 32 ? ? . cord-333986-xkx181ek 247 1 Mass mass JJ cord-333986-xkx181ek 247 2 masking masking NN cord-333986-xkx181ek 247 3 in in IN cord-333986-xkx181ek 247 4 the the DT cord-333986-xkx181ek 247 5 COVID-19 covid-19 JJ cord-333986-xkx181ek 247 6 epidemic epidemic NN cord-333986-xkx181ek 248 1 : : : cord-333986-xkx181ek 248 2 People People NNS cord-333986-xkx181ek 248 3 need need VBP cord-333986-xkx181ek 248 4 guidance guidance NN cord-333986-xkx181ek 248 5 Sanchis Sanchis NNP cord-333986-xkx181ek 248 6 - - HYPH cord-333986-xkx181ek 248 7 Gomar Gomar NNP cord-333986-xkx181ek 248 8 , , , cord-333986-xkx181ek 248 9 F. F. NNP cord-333986-xkx181ek 248 10 Health Health NNP cord-333986-xkx181ek 248 11 risks risk NNS cord-333986-xkx181ek 248 12 and and CC cord-333986-xkx181ek 248 13 potential potential JJ cord-333986-xkx181ek 248 14 remedies remedy NNS cord-333986-xkx181ek 248 15 during during IN cord-333986-xkx181ek 248 16 prolonged prolonged JJ cord-333986-xkx181ek 248 17 lockdowns lockdown NNS cord-333986-xkx181ek 248 18 for for IN cord-333986-xkx181ek 248 19 coronavirus coronavirus NN cord-333986-xkx181ek 248 20 disease disease NN cord-333986-xkx181ek 248 21 2019 2019 CD cord-333986-xkx181ek 248 22 ( ( -LRB- cord-333986-xkx181ek 248 23 COVID-19 COVID-19 NNP cord-333986-xkx181ek 248 24 ) ) -RRB- cord-333986-xkx181ek 248 25 Position Position NNP cord-333986-xkx181ek 248 26 statement statement NN cord-333986-xkx181ek 248 27 part part NN cord-333986-xkx181ek 248 28 one one CD cord-333986-xkx181ek 248 29 : : : cord-333986-xkx181ek 248 30 Immune immune JJ cord-333986-xkx181ek 248 31 function function NN cord-333986-xkx181ek 248 32 and and CC cord-333986-xkx181ek 248 33 exercise exercise VB cord-333986-xkx181ek 248 34 Exercise exercise NN cord-333986-xkx181ek 248 35 and and CC cord-333986-xkx181ek 248 36 respiratory respiratory JJ cord-333986-xkx181ek 248 37 tract tract NN cord-333986-xkx181ek 248 38 viral viral JJ cord-333986-xkx181ek 248 39 infections infection NNS cord-333986-xkx181ek 249 1 Exercise exercise NN cord-333986-xkx181ek 249 2 immunology immunology NN cord-333986-xkx181ek 249 3 : : : cord-333986-xkx181ek 250 1 Future future JJ cord-333986-xkx181ek 250 2 directions direction NNS cord-333986-xkx181ek 251 1 The the DT cord-333986-xkx181ek 251 2 compelling compelling JJ cord-333986-xkx181ek 251 3 link link NN cord-333986-xkx181ek 251 4 between between IN cord-333986-xkx181ek 251 5 physical physical JJ cord-333986-xkx181ek 251 6 activity activity NN cord-333986-xkx181ek 251 7 and and CC cord-333986-xkx181ek 251 8 the the DT cord-333986-xkx181ek 251 9 body body NN cord-333986-xkx181ek 251 10 's 's POS cord-333986-xkx181ek 251 11 defense defense NN cord-333986-xkx181ek 251 12 system system NN cord-333986-xkx181ek 252 1 The the DT cord-333986-xkx181ek 252 2 immunological immunological JJ cord-333986-xkx181ek 252 3 case case NN cord-333986-xkx181ek 252 4 for for IN cord-333986-xkx181ek 252 5 staying stay VBG cord-333986-xkx181ek 252 6 active active JJ cord-333986-xkx181ek 252 7 during during IN cord-333986-xkx181ek 252 8 the the DT cord-333986-xkx181ek 252 9 COVID-19 COVID-19 NNP cord-333986-xkx181ek 252 10 pandemic pandemic NN cord-333986-xkx181ek 252 11 SARS SARS NNP cord-333986-xkx181ek 252 12 - - HYPH cord-333986-xkx181ek 252 13 CoV-2 CoV-2 NNP cord-333986-xkx181ek 252 14 and and CC cord-333986-xkx181ek 252 15 COVID-19 covid-19 VB cord-333986-xkx181ek 252 16 in in IN cord-333986-xkx181ek 252 17 older old JJR cord-333986-xkx181ek 252 18 adults adult NNS cord-333986-xkx181ek 252 19 : : : cord-333986-xkx181ek 253 1 What what WP cord-333986-xkx181ek 253 2 we -PRON- PRP cord-333986-xkx181ek 253 3 may may MD cord-333986-xkx181ek 253 4 expect expect VB cord-333986-xkx181ek 253 5 regarding regard VBG cord-333986-xkx181ek 253 6 pathogenesis pathogenesis NN cord-333986-xkx181ek 253 7 , , , cord-333986-xkx181ek 253 8 immune immune JJ cord-333986-xkx181ek 253 9 responses response NNS cord-333986-xkx181ek 253 10 , , , cord-333986-xkx181ek 253 11 and and CC cord-333986-xkx181ek 253 12 outcomes outcome NNS cord-333986-xkx181ek 254 1 COVID-19 covid-19 VB cord-333986-xkx181ek 254 2 and and CC cord-333986-xkx181ek 254 3 older old JJR cord-333986-xkx181ek 254 4 adults adult NNS cord-333986-xkx181ek 254 5 : : : cord-333986-xkx181ek 255 1 What what WP cord-333986-xkx181ek 255 2 we -PRON- PRP cord-333986-xkx181ek 255 3 know know VBP cord-333986-xkx181ek 256 1 Covid-19 Covid-19 NNP cord-333986-xkx181ek 256 2 : : : cord-333986-xkx181ek 256 3 Risk Risk NNP cord-333986-xkx181ek 256 4 Factors factor NNS cord-333986-xkx181ek 256 5 for for IN cord-333986-xkx181ek 256 6 Severe Severe NNP cord-333986-xkx181ek 256 7 Disease Disease NNP cord-333986-xkx181ek 256 8 and and CC cord-333986-xkx181ek 256 9 Death Death NNP cord-333986-xkx181ek 256 10 Case case NN cord-333986-xkx181ek 256 11 - - HYPH cord-333986-xkx181ek 256 12 fatality fatality NN cord-333986-xkx181ek 256 13 rate rate NN cord-333986-xkx181ek 256 14 and and CC cord-333986-xkx181ek 256 15 characteristics characteristic NNS cord-333986-xkx181ek 256 16 of of IN cord-333986-xkx181ek 256 17 patients patient NNS cord-333986-xkx181ek 256 18 dying die VBG cord-333986-xkx181ek 256 19 in in IN cord-333986-xkx181ek 256 20 relation relation NN cord-333986-xkx181ek 256 21 to to IN cord-333986-xkx181ek 256 22 COVID-19 covid-19 VB cord-333986-xkx181ek 256 23 in in IN cord-333986-xkx181ek 256 24 Italy Italy NNP cord-333986-xkx181ek 257 1 Defining define VBG cord-333986-xkx181ek 257 2 the the DT cord-333986-xkx181ek 257 3 epidemiology epidemiology NN cord-333986-xkx181ek 257 4 of of IN cord-333986-xkx181ek 257 5 Covid-19-Studies covid-19-studie NNS cord-333986-xkx181ek 257 6 needed need VBD cord-333986-xkx181ek 257 7 The the DT cord-333986-xkx181ek 257 8 effect effect NN cord-333986-xkx181ek 257 9 of of IN cord-333986-xkx181ek 257 10 frailty frailty NN cord-333986-xkx181ek 257 11 on on IN cord-333986-xkx181ek 257 12 survival survival NN cord-333986-xkx181ek 257 13 in in IN cord-333986-xkx181ek 257 14 patients patient NNS cord-333986-xkx181ek 257 15 with with IN cord-333986-xkx181ek 257 16 COVID-19 COVID-19 NNP cord-333986-xkx181ek 257 17 ( ( -LRB- cord-333986-xkx181ek 257 18 COPE COPE NNP cord-333986-xkx181ek 257 19 ) ) -RRB- cord-333986-xkx181ek 257 20 : : : cord-333986-xkx181ek 258 1 A a DT cord-333986-xkx181ek 258 2 multicentre multicentre NN cord-333986-xkx181ek 258 3 , , , cord-333986-xkx181ek 258 4 European european JJ cord-333986-xkx181ek 258 5 , , , cord-333986-xkx181ek 258 6 observational observational JJ cord-333986-xkx181ek 258 7 cohort cohort NN cord-333986-xkx181ek 258 8 study study NN cord-333986-xkx181ek 258 9 Impact Impact NNP cord-333986-xkx181ek 258 10 of of IN cord-333986-xkx181ek 258 11 the the DT cord-333986-xkx181ek 258 12 COVID-19 covid-19 JJ cord-333986-xkx181ek 258 13 pandemic pandemic NN cord-333986-xkx181ek 258 14 on on IN cord-333986-xkx181ek 258 15 Parkinson Parkinson NNP cord-333986-xkx181ek 258 16 's 's POS cord-333986-xkx181ek 258 17 disease disease NN cord-333986-xkx181ek 258 18 and and CC cord-333986-xkx181ek 258 19 movement movement NN cord-333986-xkx181ek 258 20 disorders disorder NNS cord-333986-xkx181ek 259 1 The the DT cord-333986-xkx181ek 259 2 impact impact NN cord-333986-xkx181ek 259 3 of of IN cord-333986-xkx181ek 259 4 the the DT cord-333986-xkx181ek 259 5 COVID-19 covid-19 JJ cord-333986-xkx181ek 259 6 pandemic pandemic NN cord-333986-xkx181ek 259 7 on on IN cord-333986-xkx181ek 259 8 Parkinson Parkinson NNP cord-333986-xkx181ek 259 9 's 's POS cord-333986-xkx181ek 259 10 disease disease NN cord-333986-xkx181ek 259 11 : : : cord-333986-xkx181ek 259 12 Hidden hide VBN cord-333986-xkx181ek 259 13 sorrows sorrow NNS cord-333986-xkx181ek 259 14 and and CC cord-333986-xkx181ek 259 15 emerging emerge VBG cord-333986-xkx181ek 259 16 opportunities opportunity NNS cord-333986-xkx181ek 260 1 Outcome outcome NN cord-333986-xkx181ek 260 2 of of IN cord-333986-xkx181ek 260 3 Parkinson Parkinson NNP cord-333986-xkx181ek 260 4 's 's POS cord-333986-xkx181ek 260 5 Disease Disease NNP cord-333986-xkx181ek 260 6 patients patient NNS cord-333986-xkx181ek 260 7 affected affect VBN cord-333986-xkx181ek 260 8 by by IN cord-333986-xkx181ek 260 9 COVID-19 COVID-19 NNP cord-333986-xkx181ek 260 10 Potential potential JJ cord-333986-xkx181ek 260 11 Role Role NNP cord-333986-xkx181ek 260 12 of of IN cord-333986-xkx181ek 260 13 Vitamin vitamin NN cord-333986-xkx181ek 260 14 D d NN cord-333986-xkx181ek 260 15 in in IN cord-333986-xkx181ek 260 16 the the DT cord-333986-xkx181ek 260 17 Elderly Elderly NNP cord-333986-xkx181ek 260 18 to to TO cord-333986-xkx181ek 260 19 Resist resist VB cord-333986-xkx181ek 260 20 COVID-19 covid-19 VB cord-333986-xkx181ek 260 21 and and CC cord-333986-xkx181ek 260 22 to to IN cord-333986-xkx181ek 260 23 Slow Slow NNP cord-333986-xkx181ek 260 24 Progression Progression NNP cord-333986-xkx181ek 260 25 of of IN cord-333986-xkx181ek 260 26 Parkinson Parkinson NNP cord-333986-xkx181ek 260 27 's 's POS cord-333986-xkx181ek 260 28 Disease Disease NNP cord-333986-xkx181ek 260 29 Mens Mens NNP cord-333986-xkx181ek 260 30 sana sana NN cord-333986-xkx181ek 260 31 in in IN cord-333986-xkx181ek 260 32 corpore corpore FW cord-333986-xkx181ek 260 33 sano sano NNP cord-333986-xkx181ek 260 34 American American NNP cord-333986-xkx181ek 260 35 College College NNP cord-333986-xkx181ek 260 36 of of IN cord-333986-xkx181ek 260 37 Sports Sports NNPS cord-333986-xkx181ek 260 38 Medicine Medicine NNP cord-333986-xkx181ek 260 39 position position NN cord-333986-xkx181ek 261 1 stand stand VB cord-333986-xkx181ek 261 2 The the DT cord-333986-xkx181ek 261 3 physical physical JJ cord-333986-xkx181ek 261 4 activity activity NN cord-333986-xkx181ek 261 5 guidelines guideline NNS cord-333986-xkx181ek 261 6 for for IN cord-333986-xkx181ek 261 7 Americans Americans NNPS cord-333986-xkx181ek 262 1 How how WRB cord-333986-xkx181ek 262 2 Much much JJ cord-333986-xkx181ek 262 3 Should Should MD cord-333986-xkx181ek 262 4 the the DT cord-333986-xkx181ek 262 5 Average Average NNP cord-333986-xkx181ek 262 6 Adult Adult NNP cord-333986-xkx181ek 262 7 Exercise Exercise NNP cord-333986-xkx181ek 262 8 Every Every NNP cord-333986-xkx181ek 262 9 Day day NN cord-333986-xkx181ek 262 10 ? ? . cord-333986-xkx181ek 263 1 Available available JJ cord-333986-xkx181ek 263 2 online online RB cord-333986-xkx181ek 264 1 Basic basic JJ cord-333986-xkx181ek 264 2 Immunology Immunology NNP cord-333986-xkx181ek 264 3 E E NNP cord-333986-xkx181ek 264 4 - - NN cord-333986-xkx181ek 264 5 Book Book NNP cord-333986-xkx181ek 264 6 : : : cord-333986-xkx181ek 264 7 Functions function NNS cord-333986-xkx181ek 264 8 and and CC cord-333986-xkx181ek 264 9 Disorders disorder NNS cord-333986-xkx181ek 264 10 of of IN cord-333986-xkx181ek 264 11 the the DT cord-333986-xkx181ek 264 12 Immune Immune NNP cord-333986-xkx181ek 264 13 System System NNP cord-333986-xkx181ek 265 1 The the DT cord-333986-xkx181ek 265 2 symptomatology symptomatology NN cord-333986-xkx181ek 265 3 of of IN cord-333986-xkx181ek 265 4 upper upper JJ cord-333986-xkx181ek 265 5 respiratory respiratory JJ cord-333986-xkx181ek 265 6 tract tract NN cord-333986-xkx181ek 265 7 infections infection NNS cord-333986-xkx181ek 265 8 and and CC cord-333986-xkx181ek 265 9 exercise exercise NN cord-333986-xkx181ek 265 10 in in IN cord-333986-xkx181ek 265 11 elderly elderly JJ cord-333986-xkx181ek 265 12 people people NNS cord-333986-xkx181ek 265 13 Moderate moderate JJ cord-333986-xkx181ek 265 14 to to IN cord-333986-xkx181ek 265 15 vigorous vigorous JJ cord-333986-xkx181ek 265 16 physical physical JJ cord-333986-xkx181ek 265 17 activity activity NN cord-333986-xkx181ek 265 18 and and CC cord-333986-xkx181ek 265 19 risk risk NN cord-333986-xkx181ek 265 20 of of IN cord-333986-xkx181ek 265 21 upper upper JJ cord-333986-xkx181ek 265 22 - - HYPH cord-333986-xkx181ek 265 23 respiratory respiratory JJ cord-333986-xkx181ek 265 24 tract tract NN cord-333986-xkx181ek 265 25 infection infection NN cord-333986-xkx181ek 265 26 Dose dose NN cord-333986-xkx181ek 265 27 - - HYPH cord-333986-xkx181ek 265 28 response response NN cord-333986-xkx181ek 265 29 relationship relationship NN cord-333986-xkx181ek 265 30 between between IN cord-333986-xkx181ek 265 31 exercise exercise NN cord-333986-xkx181ek 265 32 and and CC cord-333986-xkx181ek 265 33 respiratory respiratory JJ cord-333986-xkx181ek 265 34 disease disease NN cord-333986-xkx181ek 265 35 mortality mortality NN cord-333986-xkx181ek 265 36 Exercise exercise NN cord-333986-xkx181ek 265 37 training training NN cord-333986-xkx181ek 265 38 changes change NNS cord-333986-xkx181ek 265 39 IL-10 IL-10 NNP cord-333986-xkx181ek 265 40 / / SYM cord-333986-xkx181ek 265 41 TNF TNF NNP cord-333986-xkx181ek 265 42 - - HYPH cord-333986-xkx181ek 265 43 alpha alpha NN cord-333986-xkx181ek 265 44 ratio ratio NN cord-333986-xkx181ek 265 45 in in IN cord-333986-xkx181ek 265 46 the the DT cord-333986-xkx181ek 265 47 skeletal skeletal JJ cord-333986-xkx181ek 265 48 muscle muscle NN cord-333986-xkx181ek 265 49 of of IN cord-333986-xkx181ek 265 50 post post JJ cord-333986-xkx181ek 265 51 - - JJ cord-333986-xkx181ek 265 52 MI MI NNP cord-333986-xkx181ek 265 53 rats rat NNS cord-333986-xkx181ek 266 1 Infectious infectious JJ cord-333986-xkx181ek 266 2 episodes episode NNS cord-333986-xkx181ek 266 3 in in IN cord-333986-xkx181ek 266 4 runners runner NNS cord-333986-xkx181ek 266 5 before before IN cord-333986-xkx181ek 266 6 and and CC cord-333986-xkx181ek 266 7 after after IN cord-333986-xkx181ek 266 8 the the DT cord-333986-xkx181ek 266 9 Los Los NNP cord-333986-xkx181ek 266 10 Angeles Angeles NNP cord-333986-xkx181ek 266 11 Marathon Marathon NNP cord-333986-xkx181ek 266 12 Moderate Moderate NNP cord-333986-xkx181ek 266 13 exercise exercise NN cord-333986-xkx181ek 267 1 early early RB cord-333986-xkx181ek 267 2 after after IN cord-333986-xkx181ek 267 3 influenza influenza NN cord-333986-xkx181ek 267 4 virus virus NN cord-333986-xkx181ek 267 5 infection infection NN cord-333986-xkx181ek 267 6 reduces reduce VBZ cord-333986-xkx181ek 267 7 the the DT cord-333986-xkx181ek 267 8 Th1 th1 CD cord-333986-xkx181ek 267 9 inflammatory inflammatory JJ cord-333986-xkx181ek 267 10 response response NN cord-333986-xkx181ek 267 11 in in IN cord-333986-xkx181ek 267 12 lungs lung NNS cord-333986-xkx181ek 267 13 of of IN cord-333986-xkx181ek 267 14 mice mouse NNS cord-333986-xkx181ek 267 15 Cytokine cytokine NN cord-333986-xkx181ek 267 16 Responses response NNS cord-333986-xkx181ek 267 17 to to IN cord-333986-xkx181ek 267 18 Acute acute JJ cord-333986-xkx181ek 267 19 Exercise exercise NN cord-333986-xkx181ek 267 20 in in IN cord-333986-xkx181ek 267 21 Healthy Healthy NNP cord-333986-xkx181ek 267 22 Older old JJR cord-333986-xkx181ek 267 23 Adults Adults NNPS cord-333986-xkx181ek 267 24 : : : cord-333986-xkx181ek 268 1 The the DT cord-333986-xkx181ek 268 2 Effect effect NN cord-333986-xkx181ek 268 3 of of IN cord-333986-xkx181ek 268 4 Cardiorespiratory Cardiorespiratory NNP cord-333986-xkx181ek 268 5 Fitness Fitness NNP cord-333986-xkx181ek 268 6 Interleukin-6 Interleukin-6 NNP cord-333986-xkx181ek 268 7 myokine myokine NN cord-333986-xkx181ek 268 8 signaling signal VBG cord-333986-xkx181ek 268 9 in in IN cord-333986-xkx181ek 268 10 skeletal skeletal JJ cord-333986-xkx181ek 268 11 muscle muscle NN cord-333986-xkx181ek 268 12 : : : cord-333986-xkx181ek 268 13 A a DT cord-333986-xkx181ek 268 14 double double RB cord-333986-xkx181ek 268 15 - - HYPH cord-333986-xkx181ek 268 16 edged edged JJ cord-333986-xkx181ek 268 17 sword sword NN cord-333986-xkx181ek 268 18 ? ? . cord-333986-xkx181ek 269 1 Role role NN cord-333986-xkx181ek 269 2 of of IN cord-333986-xkx181ek 269 3 interleukin-6 interleukin-6 NNP cord-333986-xkx181ek 269 4 and and CC cord-333986-xkx181ek 269 5 interleukin-15 interleukin-15 CD cord-333986-xkx181ek 269 6 in in IN cord-333986-xkx181ek 269 7 exercise exercise NN cord-333986-xkx181ek 269 8 The the DT cord-333986-xkx181ek 269 9 anti anti JJ cord-333986-xkx181ek 269 10 - - JJ cord-333986-xkx181ek 269 11 inflammatory inflammatory JJ cord-333986-xkx181ek 269 12 effect effect NN cord-333986-xkx181ek 269 13 of of IN cord-333986-xkx181ek 269 14 exercise exercise NN cord-333986-xkx181ek 269 15 Beneficial beneficial JJ cord-333986-xkx181ek 269 16 health health NN cord-333986-xkx181ek 269 17 effects effect NNS cord-333986-xkx181ek 269 18 of of IN cord-333986-xkx181ek 269 19 exercise exercise NN cord-333986-xkx181ek 269 20 - - : cord-333986-xkx181ek 269 21 the the DT cord-333986-xkx181ek 269 22 role role NN cord-333986-xkx181ek 269 23 of of IN cord-333986-xkx181ek 269 24 IL-6 IL-6 NNP cord-333986-xkx181ek 269 25 as as IN cord-333986-xkx181ek 269 26 a a DT cord-333986-xkx181ek 269 27 myokine myokine NN cord-333986-xkx181ek 269 28 Interleukin-6 Interleukin-6 NNP cord-333986-xkx181ek 269 29 in in IN cord-333986-xkx181ek 269 30 acute acute JJ cord-333986-xkx181ek 269 31 exercise exercise NN cord-333986-xkx181ek 269 32 and and CC cord-333986-xkx181ek 269 33 training training NN cord-333986-xkx181ek 270 1 : : : cord-333986-xkx181ek 270 2 What what WP cord-333986-xkx181ek 270 3 is be VBZ cord-333986-xkx181ek 270 4 the the DT cord-333986-xkx181ek 270 5 biological biological JJ cord-333986-xkx181ek 270 6 relevance relevance NN cord-333986-xkx181ek 270 7 ? ? . cord-333986-xkx181ek 271 1 Exercise Exercise NNP cord-333986-xkx181ek 271 2 and and CC cord-333986-xkx181ek 271 3 IL-6 IL-6 NNP cord-333986-xkx181ek 271 4 infusion infusion NN cord-333986-xkx181ek 271 5 inhibit inhibit VB cord-333986-xkx181ek 271 6 endotoxin endotoxin NN cord-333986-xkx181ek 271 7 - - HYPH cord-333986-xkx181ek 271 8 induced induce VBN cord-333986-xkx181ek 271 9 TNF tnf NN cord-333986-xkx181ek 271 10 - - HYPH cord-333986-xkx181ek 271 11 alpha alpha NN cord-333986-xkx181ek 271 12 production production NN cord-333986-xkx181ek 271 13 in in IN cord-333986-xkx181ek 271 14 humans human NNS cord-333986-xkx181ek 271 15 Toll Toll NNP cord-333986-xkx181ek 271 16 - - HYPH cord-333986-xkx181ek 271 17 like like JJ cord-333986-xkx181ek 271 18 receptors receptor NNS cord-333986-xkx181ek 271 19 in in IN cord-333986-xkx181ek 271 20 immunity immunity NN cord-333986-xkx181ek 271 21 and and CC cord-333986-xkx181ek 271 22 inflammatory inflammatory JJ cord-333986-xkx181ek 271 23 diseases disease NNS cord-333986-xkx181ek 271 24 : : : cord-333986-xkx181ek 272 1 Past past NN cord-333986-xkx181ek 272 2 , , , cord-333986-xkx181ek 272 3 present present JJ cord-333986-xkx181ek 272 4 , , , cord-333986-xkx181ek 272 5 and and CC cord-333986-xkx181ek 272 6 future future JJ cord-333986-xkx181ek 272 7 Toll toll NN cord-333986-xkx181ek 272 8 - - HYPH cord-333986-xkx181ek 272 9 like like JJ cord-333986-xkx181ek 272 10 receptor receptor NN cord-333986-xkx181ek 272 11 4 4 CD cord-333986-xkx181ek 272 12 and and CC cord-333986-xkx181ek 272 13 CD14 CD14 NNP cord-333986-xkx181ek 272 14 mRNA mRNA NNP cord-333986-xkx181ek 272 15 expression expression NN cord-333986-xkx181ek 272 16 are be VBP cord-333986-xkx181ek 272 17 lower low JJR cord-333986-xkx181ek 272 18 in in IN cord-333986-xkx181ek 272 19 resistive resistive JJ cord-333986-xkx181ek 272 20 exercise exercise NN cord-333986-xkx181ek 272 21 - - HYPH cord-333986-xkx181ek 272 22 trained train VBN cord-333986-xkx181ek 272 23 elderly elderly JJ cord-333986-xkx181ek 272 24 women woman NNS cord-333986-xkx181ek 272 25 Toll toll NN cord-333986-xkx181ek 272 26 - - HYPH cord-333986-xkx181ek 272 27 like like JJ cord-333986-xkx181ek 272 28 receptor receptor NN cord-333986-xkx181ek 272 29 4 4 CD cord-333986-xkx181ek 272 30 : : : cord-333986-xkx181ek 273 1 Link link VB cord-333986-xkx181ek 273 2 to to IN cord-333986-xkx181ek 273 3 the the DT cord-333986-xkx181ek 273 4 anti anti JJ cord-333986-xkx181ek 273 5 - - JJ cord-333986-xkx181ek 273 6 inflammatory inflammatory JJ cord-333986-xkx181ek 273 7 effects effect NNS cord-333986-xkx181ek 273 8 of of IN cord-333986-xkx181ek 273 9 exercise exercise NN cord-333986-xkx181ek 273 10 ? ? . cord-333986-xkx181ek 274 1 Acute acute JJ cord-333986-xkx181ek 274 2 exercise exercise NN cord-333986-xkx181ek 274 3 and and CC cord-333986-xkx181ek 274 4 oxidative oxidative JJ cord-333986-xkx181ek 274 5 stress stress NN cord-333986-xkx181ek 274 6 : : : cord-333986-xkx181ek 275 1 A a DT cord-333986-xkx181ek 275 2 30 30 CD cord-333986-xkx181ek 275 3 year year NN cord-333986-xkx181ek 275 4 history history NN cord-333986-xkx181ek 275 5 Reduction reduction NN cord-333986-xkx181ek 275 6 of of IN cord-333986-xkx181ek 275 7 saliva saliva NN cord-333986-xkx181ek 275 8 immunoglobulin immunoglobulin NN cord-333986-xkx181ek 275 9 levels level NNS cord-333986-xkx181ek 275 10 by by IN cord-333986-xkx181ek 275 11 swim swim NN cord-333986-xkx181ek 275 12 training training NN cord-333986-xkx181ek 275 13 Role role NN cord-333986-xkx181ek 275 14 of of IN cord-333986-xkx181ek 275 15 α α NNP cord-333986-xkx181ek 275 16 - - HYPH cord-333986-xkx181ek 275 17 synuclein synuclein NNP cord-333986-xkx181ek 275 18 in in IN cord-333986-xkx181ek 275 19 inducing induce VBG cord-333986-xkx181ek 275 20 innate innate JJ cord-333986-xkx181ek 275 21 and and CC cord-333986-xkx181ek 275 22 adaptive adaptive JJ cord-333986-xkx181ek 275 23 immunity immunity NN cord-333986-xkx181ek 275 24 in in IN cord-333986-xkx181ek 275 25 Parkinson Parkinson NNP cord-333986-xkx181ek 275 26 disease disease NN cord-333986-xkx181ek 276 1 The the DT cord-333986-xkx181ek 276 2 role role NN cord-333986-xkx181ek 276 3 of of IN cord-333986-xkx181ek 276 4 innate innate JJ cord-333986-xkx181ek 276 5 and and CC cord-333986-xkx181ek 276 6 adaptive adaptive JJ cord-333986-xkx181ek 276 7 immunity immunity NN cord-333986-xkx181ek 276 8 in in IN cord-333986-xkx181ek 276 9 Parkinson Parkinson NNP cord-333986-xkx181ek 276 10 's 's POS cord-333986-xkx181ek 276 11 disease disease NN cord-333986-xkx181ek 276 12 . . . cord-333986-xkx181ek 277 1 J. J. NNP cord-333986-xkx181ek 277 2 Parkinson Parkinson NNP cord-333986-xkx181ek 277 3 's 's POS cord-333986-xkx181ek 277 4 Dis Dis NNP cord-333986-xkx181ek 277 5 Neuroinflammation Neuroinflammation NNP cord-333986-xkx181ek 277 6 in in IN cord-333986-xkx181ek 277 7 Parkinson Parkinson NNP cord-333986-xkx181ek 277 8 's 's POS cord-333986-xkx181ek 277 9 disease disease NN cord-333986-xkx181ek 277 10 and and CC cord-333986-xkx181ek 277 11 its -PRON- PRP$ cord-333986-xkx181ek 277 12 potential potential NN cord-333986-xkx181ek 277 13 as as IN cord-333986-xkx181ek 277 14 therapeutic therapeutic JJ cord-333986-xkx181ek 277 15 target target NN cord-333986-xkx181ek 277 16 Exercise exercise NN cord-333986-xkx181ek 277 17 - - HYPH cord-333986-xkx181ek 277 18 Induced induce VBN cord-333986-xkx181ek 277 19 Neuroprotection Neuroprotection NNP cord-333986-xkx181ek 277 20 and and CC cord-333986-xkx181ek 277 21 Recovery Recovery NNP cord-333986-xkx181ek 277 22 of of IN cord-333986-xkx181ek 277 23 Motor Motor NNP cord-333986-xkx181ek 277 24 Function Function NNP cord-333986-xkx181ek 277 25 in in IN cord-333986-xkx181ek 277 26 Animal Animal NNP cord-333986-xkx181ek 277 27 Models Models NNPS cord-333986-xkx181ek 277 28 of of IN cord-333986-xkx181ek 277 29 Alpha Alpha NNP cord-333986-xkx181ek 277 30 - - HYPH cord-333986-xkx181ek 277 31 Synuclein Synuclein NNP cord-333986-xkx181ek 277 32 in in IN cord-333986-xkx181ek 277 33 Parkinson Parkinson NNP cord-333986-xkx181ek 277 34 's 's POS cord-333986-xkx181ek 277 35 Disease Disease NNP cord-333986-xkx181ek 277 36 : : : cord-333986-xkx181ek 278 1 From from IN cord-333986-xkx181ek 278 2 Pathogenetic Pathogenetic NNP cord-333986-xkx181ek 278 3 Dysfunction Dysfunction NNP cord-333986-xkx181ek 278 4 to to IN cord-333986-xkx181ek 278 5 Potential Potential NNP cord-333986-xkx181ek 278 6 Clinical Clinical NNP cord-333986-xkx181ek 278 7 Application Application NNP cord-333986-xkx181ek 278 8 Neuroprotective Neuroprotective NNP cord-333986-xkx181ek 278 9 effects effect NNS cord-333986-xkx181ek 278 10 of of IN cord-333986-xkx181ek 278 11 endurance endurance NN cord-333986-xkx181ek 278 12 exercise exercise NN cord-333986-xkx181ek 278 13 against against IN cord-333986-xkx181ek 278 14 neuroinflammation neuroinflammation NN cord-333986-xkx181ek 278 15 in in IN cord-333986-xkx181ek 278 16 MPTP MPTP NNP cord-333986-xkx181ek 278 17 - - HYPH cord-333986-xkx181ek 278 18 induced induce VBN cord-333986-xkx181ek 278 19 Parkinson Parkinson NNP cord-333986-xkx181ek 278 20 's 's POS cord-333986-xkx181ek 278 21 disease disease NN cord-333986-xkx181ek 278 22 mice mouse NNS cord-333986-xkx181ek 278 23 Neuroplasticity Neuroplasticity NNP cord-333986-xkx181ek 278 24 and and CC cord-333986-xkx181ek 278 25 Neuroprotective Neuroprotective NNP cord-333986-xkx181ek 278 26 Effect Effect NNP cord-333986-xkx181ek 278 27 of of IN cord-333986-xkx181ek 278 28 Treadmill Treadmill NNP cord-333986-xkx181ek 278 29 Training Training NNP cord-333986-xkx181ek 278 30 in in IN cord-333986-xkx181ek 278 31 the the DT cord-333986-xkx181ek 278 32 Chronic Chronic NNP cord-333986-xkx181ek 278 33 Mouse Mouse NNP cord-333986-xkx181ek 278 34 Model Model NNP cord-333986-xkx181ek 278 35 of of IN cord-333986-xkx181ek 278 36 Parkinson Parkinson NNP cord-333986-xkx181ek 278 37 's 's POS cord-333986-xkx181ek 278 38 Disease Disease NNP cord-333986-xkx181ek 278 39 Moderate Moderate NNP cord-333986-xkx181ek 278 40 treadmill treadmill NN cord-333986-xkx181ek 278 41 exercise exercise NN cord-333986-xkx181ek 278 42 prevents prevent VBZ cord-333986-xkx181ek 278 43 oxidative oxidative JJ cord-333986-xkx181ek 278 44 stress stress NN cord-333986-xkx181ek 278 45 - - HYPH cord-333986-xkx181ek 278 46 induced induce VBN cord-333986-xkx181ek 278 47 anxiety anxiety NN cord-333986-xkx181ek 278 48 - - HYPH cord-333986-xkx181ek 278 49 like like JJ cord-333986-xkx181ek 278 50 behavior behavior NN cord-333986-xkx181ek 278 51 in in IN cord-333986-xkx181ek 278 52 rats rat NNS cord-333986-xkx181ek 278 53 Forced force VBD cord-333986-xkx181ek 278 54 treadmill treadmill NN cord-333986-xkx181ek 278 55 exercise exercise NN cord-333986-xkx181ek 278 56 training training NN cord-333986-xkx181ek 278 57 exacerbates exacerbate VBZ cord-333986-xkx181ek 278 58 inflammation inflammation NN cord-333986-xkx181ek 278 59 and and CC cord-333986-xkx181ek 278 60 causes cause NNS cord-333986-xkx181ek 278 61 mortality mortality NN cord-333986-xkx181ek 278 62 while while IN cord-333986-xkx181ek 278 63 voluntary voluntary JJ cord-333986-xkx181ek 278 64 wheel wheel NN cord-333986-xkx181ek 278 65 training training NN cord-333986-xkx181ek 278 66 is be VBZ cord-333986-xkx181ek 278 67 protective protective JJ cord-333986-xkx181ek 278 68 in in IN cord-333986-xkx181ek 278 69 a a DT cord-333986-xkx181ek 278 70 mouse mouse NN cord-333986-xkx181ek 278 71 model model NN cord-333986-xkx181ek 278 72 of of IN cord-333986-xkx181ek 278 73 colitis colitis NN cord-333986-xkx181ek 278 74 Moderate moderate JJ cord-333986-xkx181ek 278 75 intensity intensity NN cord-333986-xkx181ek 278 76 treadmill treadmill NN cord-333986-xkx181ek 278 77 exercise exercise NN cord-333986-xkx181ek 278 78 alters alter VBZ cord-333986-xkx181ek 278 79 food food NN cord-333986-xkx181ek 278 80 preference preference NN cord-333986-xkx181ek 278 81 via via IN cord-333986-xkx181ek 278 82 dopaminergic dopaminergic JJ cord-333986-xkx181ek 278 83 plasticity plasticity NN cord-333986-xkx181ek 278 84 of of IN cord-333986-xkx181ek 278 85 ventral ventral JJ cord-333986-xkx181ek 278 86 tegmental tegmental JJ cord-333986-xkx181ek 278 87 area area NN cord-333986-xkx181ek 278 88 - - HYPH cord-333986-xkx181ek 278 89 nucleus nucleus NN cord-333986-xkx181ek 278 90 accumbens accumben VBD cord-333986-xkx181ek 278 91 in in IN cord-333986-xkx181ek 278 92 obese obese JJ cord-333986-xkx181ek 278 93 mice mouse NNS cord-333986-xkx181ek 278 94 Running run VBG cord-333986-xkx181ek 278 95 wheel wheel NN cord-333986-xkx181ek 278 96 exercise exercise NN cord-333986-xkx181ek 278 97 reduces reduce VBZ cord-333986-xkx181ek 278 98 α α NNP cord-333986-xkx181ek 278 99 - - HYPH cord-333986-xkx181ek 278 100 synuclein synuclein NN cord-333986-xkx181ek 278 101 aggregation aggregation NN cord-333986-xkx181ek 278 102 and and CC cord-333986-xkx181ek 278 103 improves improve VBZ cord-333986-xkx181ek 278 104 motor motor NN cord-333986-xkx181ek 278 105 and and CC cord-333986-xkx181ek 278 106 cognitive cognitive JJ cord-333986-xkx181ek 278 107 function function NN cord-333986-xkx181ek 278 108 in in IN cord-333986-xkx181ek 278 109 a a DT cord-333986-xkx181ek 278 110 transgenic transgenic JJ cord-333986-xkx181ek 278 111 mouse mouse NN cord-333986-xkx181ek 278 112 model model NN cord-333986-xkx181ek 278 113 of of IN cord-333986-xkx181ek 278 114 Parkinson Parkinson NNP cord-333986-xkx181ek 278 115 's 's POS cord-333986-xkx181ek 278 116 disease disease NN cord-333986-xkx181ek 278 117 Neuroprotective Neuroprotective NNP cord-333986-xkx181ek 278 118 effects effect NNS cord-333986-xkx181ek 278 119 of of IN cord-333986-xkx181ek 278 120 swimming swimming NN cord-333986-xkx181ek 278 121 training training NN cord-333986-xkx181ek 278 122 in in IN cord-333986-xkx181ek 278 123 a a DT cord-333986-xkx181ek 278 124 mouse mouse NN cord-333986-xkx181ek 278 125 model model NN cord-333986-xkx181ek 278 126 of of IN cord-333986-xkx181ek 278 127 Parkinson Parkinson NNP cord-333986-xkx181ek 278 128 's 's POS cord-333986-xkx181ek 278 129 disease disease NN cord-333986-xkx181ek 278 130 induced induce VBN cord-333986-xkx181ek 278 131 by by IN cord-333986-xkx181ek 278 132 6-hydroxydopamine 6-hydroxydopamine CD cord-333986-xkx181ek 278 133 Bridging Bridging NNP cord-333986-xkx181ek 278 134 animal animal NN cord-333986-xkx181ek 278 135 and and CC cord-333986-xkx181ek 278 136 human human JJ cord-333986-xkx181ek 278 137 models model NNS cord-333986-xkx181ek 278 138 of of IN cord-333986-xkx181ek 278 139 exercise exercise NN cord-333986-xkx181ek 278 140 - - HYPH cord-333986-xkx181ek 278 141 induced induce VBN cord-333986-xkx181ek 278 142 brain brain NN cord-333986-xkx181ek 278 143 plasticity plasticity NN cord-333986-xkx181ek 278 144 Intensive intensive JJ cord-333986-xkx181ek 278 145 amplitude amplitude NN cord-333986-xkx181ek 278 146 - - HYPH cord-333986-xkx181ek 278 147 specific specific JJ cord-333986-xkx181ek 278 148 therapeutic therapeutic JJ cord-333986-xkx181ek 278 149 approaches approach NNS cord-333986-xkx181ek 278 150 for for IN cord-333986-xkx181ek 278 151 Parkinson Parkinson NNP cord-333986-xkx181ek 278 152 's 's POS cord-333986-xkx181ek 278 153 disease disease NN cord-333986-xkx181ek 278 154 : : : cord-333986-xkx181ek 279 1 Toward toward IN cord-333986-xkx181ek 279 2 a a DT cord-333986-xkx181ek 279 3 neuroplasticity neuroplasticity NN cord-333986-xkx181ek 279 4 - - HYPH cord-333986-xkx181ek 279 5 principled principled JJ cord-333986-xkx181ek 279 6 rehabilitation rehabilitation NN cord-333986-xkx181ek 279 7 model model NN cord-333986-xkx181ek 279 8 Effects effect NNS cord-333986-xkx181ek 279 9 of of IN cord-333986-xkx181ek 279 10 exercise exercise NN cord-333986-xkx181ek 279 11 on on IN cord-333986-xkx181ek 279 12 non non JJ cord-333986-xkx181ek 279 13 - - JJ cord-333986-xkx181ek 279 14 motor motor JJ cord-333986-xkx181ek 279 15 symptoms symptom NNS cord-333986-xkx181ek 279 16 in in IN cord-333986-xkx181ek 279 17 Parkinson Parkinson NNP cord-333986-xkx181ek 279 18 's 's POS cord-333986-xkx181ek 279 19 disease disease NN cord-333986-xkx181ek 280 1 The the DT cord-333986-xkx181ek 280 2 need need NN cord-333986-xkx181ek 280 3 for for IN cord-333986-xkx181ek 280 4 mapping map VBG cord-333986-xkx181ek 280 5 personal personal JJ cord-333986-xkx181ek 280 6 goals goal NNS cord-333986-xkx181ek 280 7 to to TO cord-333986-xkx181ek 280 8 exercise exercise VB cord-333986-xkx181ek 280 9 dosage dosage NN cord-333986-xkx181ek 280 10 in in IN cord-333986-xkx181ek 280 11 community community NN cord-333986-xkx181ek 280 12 - - HYPH cord-333986-xkx181ek 280 13 based base VBN cord-333986-xkx181ek 280 14 exercise exercise NN cord-333986-xkx181ek 280 15 programs program NNS cord-333986-xkx181ek 280 16 for for IN cord-333986-xkx181ek 280 17 people people NNS cord-333986-xkx181ek 280 18 with with IN cord-333986-xkx181ek 280 19 Parkinson Parkinson NNP cord-333986-xkx181ek 280 20 's 's POS cord-333986-xkx181ek 280 21 disease disease NN cord-333986-xkx181ek 280 22 Physical physical JJ cord-333986-xkx181ek 280 23 exercise exercise NN cord-333986-xkx181ek 280 24 for for IN cord-333986-xkx181ek 280 25 parkinson parkinson NNP cord-333986-xkx181ek 280 26 's 's POS cord-333986-xkx181ek 280 27 disease disease NN cord-333986-xkx181ek 280 28 : : : cord-333986-xkx181ek 280 29 Clinical clinical JJ cord-333986-xkx181ek 280 30 and and CC cord-333986-xkx181ek 280 31 experimental experimental JJ cord-333986-xkx181ek 280 32 evidence evidence NN cord-333986-xkx181ek 280 33 Mobilizing mobilize VBG cord-333986-xkx181ek 280 34 Parkinson Parkinson NNP cord-333986-xkx181ek 280 35 's 's POS cord-333986-xkx181ek 280 36 disease disease NN cord-333986-xkx181ek 280 37 : : : cord-333986-xkx181ek 281 1 The the DT cord-333986-xkx181ek 281 2 future future NN cord-333986-xkx181ek 281 3 of of IN cord-333986-xkx181ek 281 4 exercise exercise NN cord-333986-xkx181ek 281 5 The the DT cord-333986-xkx181ek 281 6 effects effect NNS cord-333986-xkx181ek 281 7 of of IN cord-333986-xkx181ek 281 8 exercise exercise NN cord-333986-xkx181ek 281 9 on on IN cord-333986-xkx181ek 281 10 cognition cognition NN cord-333986-xkx181ek 281 11 and and CC cord-333986-xkx181ek 281 12 gait gait NN cord-333986-xkx181ek 281 13 in in IN cord-333986-xkx181ek 281 14 Parkinson Parkinson NNP cord-333986-xkx181ek 281 15 's 's POS cord-333986-xkx181ek 281 16 disease disease NN cord-333986-xkx181ek 281 17 : : : cord-333986-xkx181ek 281 18 A a DT cord-333986-xkx181ek 281 19 scoping scoping NN cord-333986-xkx181ek 281 20 review review NN cord-333986-xkx181ek 281 21 Regular regular JJ cord-333986-xkx181ek 281 22 exercise exercise NN cord-333986-xkx181ek 281 23 , , , cord-333986-xkx181ek 281 24 quality quality NN cord-333986-xkx181ek 281 25 of of IN cord-333986-xkx181ek 281 26 life life NN cord-333986-xkx181ek 281 27 , , , cord-333986-xkx181ek 281 28 and and CC cord-333986-xkx181ek 281 29 mobility mobility NN cord-333986-xkx181ek 281 30 in in IN cord-333986-xkx181ek 281 31 Parkinson Parkinson NNP cord-333986-xkx181ek 281 32 's 's POS cord-333986-xkx181ek 281 33 disease disease NN cord-333986-xkx181ek 281 34 : : : cord-333986-xkx181ek 281 35 A a DT cord-333986-xkx181ek 281 36 longitudinal longitudinal JJ cord-333986-xkx181ek 281 37 analysis analysis NN cord-333986-xkx181ek 281 38 of of IN cord-333986-xkx181ek 281 39 National National NNP cord-333986-xkx181ek 281 40 Parkinson Parkinson NNP cord-333986-xkx181ek 281 41 Foundation Foundation NNP cord-333986-xkx181ek 281 42 quality quality NN cord-333986-xkx181ek 281 43 improvement improvement NN cord-333986-xkx181ek 281 44 initiative initiative NN cord-333986-xkx181ek 281 45 data datum NNS cord-333986-xkx181ek 281 46 . . . cord-333986-xkx181ek 282 1 J. J. NNP cord-333986-xkx181ek 282 2 Parkinson Parkinson NNP cord-333986-xkx181ek 282 3 's 's POS cord-333986-xkx181ek 282 4 Dis Dis NNP cord-333986-xkx181ek 282 5 Progressive progressive JJ cord-333986-xkx181ek 282 6 resistance resistance NN cord-333986-xkx181ek 282 7 exercise exercise NN cord-333986-xkx181ek 282 8 and and CC cord-333986-xkx181ek 282 9 Parkinson Parkinson NNP cord-333986-xkx181ek 282 10 's 's POS cord-333986-xkx181ek 282 11 disease disease NN cord-333986-xkx181ek 282 12 : : : cord-333986-xkx181ek 282 13 A a DT cord-333986-xkx181ek 282 14 review review NN cord-333986-xkx181ek 282 15 of of IN cord-333986-xkx181ek 282 16 potential potential JJ cord-333986-xkx181ek 282 17 mechanisms mechanism NNS cord-333986-xkx181ek 282 18 . . . cord-333986-xkx181ek 283 1 Parkinson Parkinson NNP cord-333986-xkx181ek 283 2 's 's POS cord-333986-xkx181ek 283 3 Dis Dis NNP cord-333986-xkx181ek 283 4 Effects effect NNS cord-333986-xkx181ek 283 5 of of IN cord-333986-xkx181ek 283 6 endurance endurance NN cord-333986-xkx181ek 283 7 exercise exercise NN cord-333986-xkx181ek 283 8 training training NN cord-333986-xkx181ek 283 9 on on IN cord-333986-xkx181ek 283 10 the the DT cord-333986-xkx181ek 283 11 motor motor NN cord-333986-xkx181ek 283 12 and and CC cord-333986-xkx181ek 283 13 non non JJ cord-333986-xkx181ek 283 14 - - JJ cord-333986-xkx181ek 283 15 motor motor JJ cord-333986-xkx181ek 283 16 features feature NNS cord-333986-xkx181ek 283 17 of of IN cord-333986-xkx181ek 283 18 Parkinson Parkinson NNP cord-333986-xkx181ek 283 19 's 's POS cord-333986-xkx181ek 283 20 disease disease NN cord-333986-xkx181ek 284 1 : : : cord-333986-xkx181ek 284 2 A a DT cord-333986-xkx181ek 284 3 review review NN cord-333986-xkx181ek 284 4 Effects effect NNS cord-333986-xkx181ek 284 5 of of IN cord-333986-xkx181ek 284 6 Two two CD cord-333986-xkx181ek 284 7 Years year NNS cord-333986-xkx181ek 284 8 of of IN cord-333986-xkx181ek 284 9 Exercise Exercise NNP cord-333986-xkx181ek 284 10 on on IN cord-333986-xkx181ek 284 11 Gait Gait NNP cord-333986-xkx181ek 284 12 Impairment Impairment NNP cord-333986-xkx181ek 284 13 in in IN cord-333986-xkx181ek 284 14 People People NNPS cord-333986-xkx181ek 284 15 with with IN cord-333986-xkx181ek 284 16 Parkinson Parkinson NNP cord-333986-xkx181ek 284 17 's 's POS cord-333986-xkx181ek 284 18 Disease Disease NNP cord-333986-xkx181ek 284 19 : : : cord-333986-xkx181ek 284 20 The the DT cord-333986-xkx181ek 284 21 PRET PRET NNP cord-333986-xkx181ek 284 22 - - HYPH cord-333986-xkx181ek 284 23 PD PD NNP cord-333986-xkx181ek 284 24 Randomized Randomized NNP cord-333986-xkx181ek 284 25 Trial Trial NNP cord-333986-xkx181ek 284 26 Does do VBZ cord-333986-xkx181ek 284 27 vigorous vigorous JJ cord-333986-xkx181ek 284 28 exercise exercise NN cord-333986-xkx181ek 284 29 have have VB cord-333986-xkx181ek 284 30 a a DT cord-333986-xkx181ek 284 31 neuroprotective neuroprotective JJ cord-333986-xkx181ek 284 32 effect effect NN cord-333986-xkx181ek 284 33 in in IN cord-333986-xkx181ek 284 34 Parkinson Parkinson NNP cord-333986-xkx181ek 284 35 disease disease NN cord-333986-xkx181ek 284 36 Effectiveness Effectiveness NNP cord-333986-xkx181ek 284 37 of of IN cord-333986-xkx181ek 284 38 home home NN cord-333986-xkx181ek 284 39 - - HYPH cord-333986-xkx181ek 284 40 based base VBN cord-333986-xkx181ek 284 41 and and CC cord-333986-xkx181ek 284 42 remotely remotely RB cord-333986-xkx181ek 284 43 supervised supervise VBN cord-333986-xkx181ek 284 44 aerobic aerobic JJ cord-333986-xkx181ek 284 45 exercise exercise NN cord-333986-xkx181ek 284 46 in in IN cord-333986-xkx181ek 284 47 Parkinson Parkinson NNP cord-333986-xkx181ek 284 48 's 's POS cord-333986-xkx181ek 284 49 disease disease NN cord-333986-xkx181ek 284 50 : : : cord-333986-xkx181ek 285 1 A a DT cord-333986-xkx181ek 285 2 double double JJ cord-333986-xkx181ek 285 3 - - HYPH cord-333986-xkx181ek 285 4 blind blind JJ cord-333986-xkx181ek 285 5 , , , cord-333986-xkx181ek 285 6 randomised randomised JJ cord-333986-xkx181ek 285 7 controlled control VBN cord-333986-xkx181ek 285 8 trial trial NN cord-333986-xkx181ek 285 9 Comparing compare VBG cord-333986-xkx181ek 285 10 the the DT cord-333986-xkx181ek 285 11 influence influence NN cord-333986-xkx181ek 285 12 of of IN cord-333986-xkx181ek 285 13 exercise exercise NN cord-333986-xkx181ek 285 14 intensity intensity NN cord-333986-xkx181ek 285 15 on on IN cord-333986-xkx181ek 285 16 brain brain NN cord-333986-xkx181ek 285 17 - - HYPH cord-333986-xkx181ek 285 18 derived derive VBN cord-333986-xkx181ek 285 19 neurotrophic neurotrophic NN cord-333986-xkx181ek 285 20 factor factor NN cord-333986-xkx181ek 285 21 serum serum NN cord-333986-xkx181ek 285 22 levels level NNS cord-333986-xkx181ek 285 23 in in IN cord-333986-xkx181ek 285 24 people people NNS cord-333986-xkx181ek 285 25 with with IN cord-333986-xkx181ek 285 26 Parkinson Parkinson NNP cord-333986-xkx181ek 285 27 's 's POS cord-333986-xkx181ek 285 28 disease disease NN cord-333986-xkx181ek 285 29 : : : cord-333986-xkx181ek 285 30 A a DT cord-333986-xkx181ek 285 31 pilot pilot NN cord-333986-xkx181ek 285 32 study study NN cord-333986-xkx181ek 285 33 Neuroplasticity neuroplasticity NN cord-333986-xkx181ek 285 34 and and CC cord-333986-xkx181ek 285 35 cognitive cognitive JJ cord-333986-xkx181ek 285 36 aging aging NN cord-333986-xkx181ek 285 37 : : : cord-333986-xkx181ek 285 38 The the DT cord-333986-xkx181ek 285 39 scaffolding scaffold VBG cord-333986-xkx181ek 285 40 theory theory NN cord-333986-xkx181ek 285 41 of of IN cord-333986-xkx181ek 285 42 aging aging NN cord-333986-xkx181ek 285 43 and and CC cord-333986-xkx181ek 285 44 cognition cognition NN cord-333986-xkx181ek 286 1 Enhancing enhance VBG cord-333986-xkx181ek 286 2 neuroplasticity neuroplasticity NN cord-333986-xkx181ek 286 3 in in IN cord-333986-xkx181ek 286 4 the the DT cord-333986-xkx181ek 286 5 basal basal NN cord-333986-xkx181ek 286 6 ganglia ganglion NNS cord-333986-xkx181ek 286 7 : : : cord-333986-xkx181ek 287 1 The the DT cord-333986-xkx181ek 287 2 role role NN cord-333986-xkx181ek 287 3 of of IN cord-333986-xkx181ek 287 4 exercise exercise NN cord-333986-xkx181ek 287 5 in in IN cord-333986-xkx181ek 287 6 Parkinson Parkinson NNP cord-333986-xkx181ek 287 7 's 's POS cord-333986-xkx181ek 287 8 disease disease NN cord-333986-xkx181ek 287 9 Forced force VBD cord-333986-xkx181ek 287 10 Limb limb NN cord-333986-xkx181ek 287 11 - - HYPH cord-333986-xkx181ek 287 12 Use Use NNP cord-333986-xkx181ek 287 13 Effects effect NNS cord-333986-xkx181ek 287 14 on on IN cord-333986-xkx181ek 287 15 the the DT cord-333986-xkx181ek 287 16 Behavioral behavioral JJ cord-333986-xkx181ek 287 17 and and CC cord-333986-xkx181ek 287 18 Neurochemical Neurochemical NNP cord-333986-xkx181ek 287 19 Effects effect NNS cord-333986-xkx181ek 287 20 of of IN cord-333986-xkx181ek 287 21 6-Hydroxydopamine 6-Hydroxydopamine NNP cord-333986-xkx181ek 287 22 Neuroprotective Neuroprotective NNP cord-333986-xkx181ek 287 23 effects effect NNS cord-333986-xkx181ek 287 24 of of IN cord-333986-xkx181ek 287 25 prior prior JJ cord-333986-xkx181ek 287 26 limb limb NN cord-333986-xkx181ek 287 27 use use NN cord-333986-xkx181ek 287 28 in in IN cord-333986-xkx181ek 287 29 6-hydroxydopamine 6-hydroxydopamine CD cord-333986-xkx181ek 287 30 - - HYPH cord-333986-xkx181ek 287 31 treated treat VBN cord-333986-xkx181ek 287 32 rats rat NNS cord-333986-xkx181ek 287 33 : : : cord-333986-xkx181ek 288 1 Possible possible JJ cord-333986-xkx181ek 288 2 role role NN cord-333986-xkx181ek 288 3 of of IN cord-333986-xkx181ek 288 4 GDNF GDNF NNP cord-333986-xkx181ek 288 5 Enriched Enriched NNP cord-333986-xkx181ek 288 6 environment environment NN cord-333986-xkx181ek 288 7 induces induce VBZ cord-333986-xkx181ek 288 8 cellular cellular JJ cord-333986-xkx181ek 288 9 plasticity plasticity NN cord-333986-xkx181ek 288 10 in in IN cord-333986-xkx181ek 288 11 the the DT cord-333986-xkx181ek 288 12 adult adult NN cord-333986-xkx181ek 288 13 substantia substantia NN cord-333986-xkx181ek 288 14 nigra nigra NNP cord-333986-xkx181ek 288 15 and and CC cord-333986-xkx181ek 288 16 improves improve VBZ cord-333986-xkx181ek 288 17 motor motor NN cord-333986-xkx181ek 288 18 behavior behavior NN cord-333986-xkx181ek 288 19 function function NN cord-333986-xkx181ek 288 20 in in IN cord-333986-xkx181ek 288 21 the the DT cord-333986-xkx181ek 288 22 6-OHDA 6-OHDA NNP cord-333986-xkx181ek 288 23 rat rat NN cord-333986-xkx181ek 288 24 model model NN cord-333986-xkx181ek 288 25 of of IN cord-333986-xkx181ek 288 26 Parkinson Parkinson NNP cord-333986-xkx181ek 288 27 's 's POS cord-333986-xkx181ek 288 28 disease disease NN cord-333986-xkx181ek 288 29 Training Training NNP cord-333986-xkx181ek 288 30 BIG big JJ cord-333986-xkx181ek 288 31 to to TO cord-333986-xkx181ek 288 32 move move VB cord-333986-xkx181ek 288 33 faster fast RBR cord-333986-xkx181ek 288 34 : : . cord-333986-xkx181ek 288 35 The the DT cord-333986-xkx181ek 288 36 application application NN cord-333986-xkx181ek 288 37 of of IN cord-333986-xkx181ek 288 38 the the DT cord-333986-xkx181ek 288 39 speed speed NN cord-333986-xkx181ek 288 40 - - HYPH cord-333986-xkx181ek 288 41 amplitude amplitude NN cord-333986-xkx181ek 288 42 relation relation NN cord-333986-xkx181ek 288 43 as as IN cord-333986-xkx181ek 288 44 a a DT cord-333986-xkx181ek 288 45 rehabilitation rehabilitation NN cord-333986-xkx181ek 288 46 strategy strategy NN cord-333986-xkx181ek 288 47 for for IN cord-333986-xkx181ek 288 48 people people NNS cord-333986-xkx181ek 288 49 with with IN cord-333986-xkx181ek 288 50 Parkinson Parkinson NNP cord-333986-xkx181ek 288 51 's 's POS cord-333986-xkx181ek 288 52 disease disease NN cord-333986-xkx181ek 288 53 . . . cord-333986-xkx181ek 289 1 Exp Exp NNP cord-333986-xkx181ek 289 2 Comparing compare VBG cord-333986-xkx181ek 289 3 exercise exercise NN cord-333986-xkx181ek 289 4 in in IN cord-333986-xkx181ek 289 5 Parkinson Parkinson NNP cord-333986-xkx181ek 289 6 's 's POS cord-333986-xkx181ek 289 7 disease disease NN cord-333986-xkx181ek 289 8 - - : cord-333986-xkx181ek 289 9 the the DT cord-333986-xkx181ek 289 10 Berlin Berlin NNP cord-333986-xkx181ek 289 11 LSVT LSVT NNP cord-333986-xkx181ek 290 1 ® ® . cord-333986-xkx181ek 291 1 BIG big JJ cord-333986-xkx181ek 291 2 study study NN cord-333986-xkx181ek 292 1 The the DT cord-333986-xkx181ek 292 2 JFK JFK NNP cord-333986-xkx181ek 292 3 BIG BIG NNP cord-333986-xkx181ek 292 4 study study NN cord-333986-xkx181ek 292 5 : : : cord-333986-xkx181ek 293 1 The the DT cord-333986-xkx181ek 293 2 impact impact NN cord-333986-xkx181ek 293 3 of of IN cord-333986-xkx181ek 293 4 LSVT LSVT NNP cord-333986-xkx181ek 293 5 BIG BIG NNP cord-333986-xkx181ek 293 6 ® ® NNP cord-333986-xkx181ek 293 7 on on IN cord-333986-xkx181ek 293 8 dual dual JJ cord-333986-xkx181ek 293 9 task task NN cord-333986-xkx181ek 293 10 walking walk VBG cord-333986-xkx181ek 293 11 and and CC cord-333986-xkx181ek 293 12 mobility mobility NN cord-333986-xkx181ek 293 13 in in IN cord-333986-xkx181ek 293 14 persons person NNS cord-333986-xkx181ek 293 15 with with IN cord-333986-xkx181ek 293 16 Parkinson Parkinson NNP cord-333986-xkx181ek 293 17 's 's POS cord-333986-xkx181ek 293 18 disease disease NN cord-333986-xkx181ek 293 19 Effect effect NN cord-333986-xkx181ek 293 20 of of IN cord-333986-xkx181ek 293 21 high high JJ cord-333986-xkx181ek 293 22 - - HYPH cord-333986-xkx181ek 293 23 intensity intensity NN cord-333986-xkx181ek 293 24 treadmill treadmill NN cord-333986-xkx181ek 293 25 exercise exercise NN cord-333986-xkx181ek 293 26 on on IN cord-333986-xkx181ek 293 27 motor motor NN cord-333986-xkx181ek 293 28 symptoms symptom NNS cord-333986-xkx181ek 293 29 in in IN cord-333986-xkx181ek 293 30 patients patient NNS cord-333986-xkx181ek 293 31 with with IN cord-333986-xkx181ek 293 32 de de NNP cord-333986-xkx181ek 293 33 novo novo NNP cord-333986-xkx181ek 293 34 Parkinson Parkinson NNP cord-333986-xkx181ek 293 35 disease disease NN cord-333986-xkx181ek 293 36 : : : cord-333986-xkx181ek 293 37 A a DT cord-333986-xkx181ek 293 38 phase phase NN cord-333986-xkx181ek 293 39 2 2 CD cord-333986-xkx181ek 293 40 randomized randomized JJ cord-333986-xkx181ek 293 41 clinical clinical JJ cord-333986-xkx181ek 293 42 trial trial NN cord-333986-xkx181ek 293 43 Multidisciplinary Multidisciplinary NNP cord-333986-xkx181ek 293 44 care care NN cord-333986-xkx181ek 293 45 to to TO cord-333986-xkx181ek 293 46 optimize optimize VB cord-333986-xkx181ek 293 47 functional functional JJ cord-333986-xkx181ek 293 48 mobility mobility NN cord-333986-xkx181ek 293 49 in in IN cord-333986-xkx181ek 293 50 Parkinson Parkinson NNP cord-333986-xkx181ek 293 51 disease disease NN cord-333986-xkx181ek 293 52 Forced force VBD cord-333986-xkx181ek 293 53 , , , cord-333986-xkx181ek 293 54 not not RB cord-333986-xkx181ek 293 55 voluntary voluntary JJ cord-333986-xkx181ek 293 56 , , , cord-333986-xkx181ek 293 57 exercise exercise NN cord-333986-xkx181ek 293 58 improves improve VBZ cord-333986-xkx181ek 293 59 motor motor NN cord-333986-xkx181ek 293 60 function function NN cord-333986-xkx181ek 293 61 in in IN cord-333986-xkx181ek 293 62 Parkinson Parkinson NNP cord-333986-xkx181ek 293 63 's 's POS cord-333986-xkx181ek 293 64 disease disease NN cord-333986-xkx181ek 293 65 patients patient NNS cord-333986-xkx181ek 293 66 Motor motor NN cord-333986-xkx181ek 293 67 - - HYPH cord-333986-xkx181ek 293 68 cognitive cognitive JJ cord-333986-xkx181ek 293 69 approach approach NN cord-333986-xkx181ek 293 70 and and CC cord-333986-xkx181ek 293 71 aerobic aerobic JJ cord-333986-xkx181ek 293 72 training training NN cord-333986-xkx181ek 293 73 : : : cord-333986-xkx181ek 294 1 A a DT cord-333986-xkx181ek 294 2 synergism synergism NN cord-333986-xkx181ek 294 3 for for IN cord-333986-xkx181ek 294 4 rehabilitative rehabilitative JJ cord-333986-xkx181ek 294 5 intervention intervention NN cord-333986-xkx181ek 294 6 in in IN cord-333986-xkx181ek 294 7 Parkinson Parkinson NNP cord-333986-xkx181ek 294 8 's 's POS cord-333986-xkx181ek 294 9 disease disease NN cord-333986-xkx181ek 295 1 The the DT cord-333986-xkx181ek 295 2 efficacy efficacy NN cord-333986-xkx181ek 295 3 of of IN cord-333986-xkx181ek 295 4 dance dance NN cord-333986-xkx181ek 295 5 for for IN cord-333986-xkx181ek 295 6 improving improve VBG cord-333986-xkx181ek 295 7 motor motor NN cord-333986-xkx181ek 295 8 impairments impairment NNS cord-333986-xkx181ek 295 9 , , , cord-333986-xkx181ek 295 10 non non JJ cord-333986-xkx181ek 295 11 - - JJ cord-333986-xkx181ek 295 12 motor motor JJ cord-333986-xkx181ek 295 13 symptoms symptom NNS cord-333986-xkx181ek 295 14 , , , cord-333986-xkx181ek 295 15 and and CC cord-333986-xkx181ek 295 16 quality quality NN cord-333986-xkx181ek 295 17 of of IN cord-333986-xkx181ek 295 18 life life NN cord-333986-xkx181ek 295 19 in in IN cord-333986-xkx181ek 295 20 Parkinson Parkinson NNP cord-333986-xkx181ek 295 21 's 's POS cord-333986-xkx181ek 295 22 disease disease NN cord-333986-xkx181ek 295 23 : : : cord-333986-xkx181ek 295 24 A a DT cord-333986-xkx181ek 295 25 systematic systematic JJ cord-333986-xkx181ek 295 26 review review NN cord-333986-xkx181ek 295 27 and and CC cord-333986-xkx181ek 295 28 meta meta NNP cord-333986-xkx181ek 295 29 - - HYPH cord-333986-xkx181ek 295 30 analysis analysis NN cord-333986-xkx181ek 296 1 A a DT cord-333986-xkx181ek 296 2 physical physical JJ cord-333986-xkx181ek 296 3 therapy therapy NN cord-333986-xkx181ek 296 4 decision decision NN cord-333986-xkx181ek 296 5 - - HYPH cord-333986-xkx181ek 296 6 making make VBG cord-333986-xkx181ek 296 7 tool tool NN cord-333986-xkx181ek 296 8 for for IN cord-333986-xkx181ek 296 9 stratifying stratify VBG cord-333986-xkx181ek 296 10 persons person NNS cord-333986-xkx181ek 296 11 with with IN cord-333986-xkx181ek 296 12 Parkinson Parkinson NNP cord-333986-xkx181ek 296 13 's 's POS cord-333986-xkx181ek 296 14 disease disease NN cord-333986-xkx181ek 296 15 into into IN cord-333986-xkx181ek 296 16 community community NN cord-333986-xkx181ek 296 17 exercise exercise NN cord-333986-xkx181ek 296 18 classes class NNS cord-333986-xkx181ek 296 19 Exercise exercise NN cord-333986-xkx181ek 296 20 - - HYPH cord-333986-xkx181ek 296 21 induced induce VBN cord-333986-xkx181ek 296 22 neuroplasticity neuroplasticity NN cord-333986-xkx181ek 296 23 : : : cord-333986-xkx181ek 296 24 A a DT cord-333986-xkx181ek 296 25 mechanistic mechanistic JJ cord-333986-xkx181ek 296 26 model model NN cord-333986-xkx181ek 296 27 and and CC cord-333986-xkx181ek 296 28 prospects prospect NNS cord-333986-xkx181ek 296 29 for for IN cord-333986-xkx181ek 296 30 promoting promote VBG cord-333986-xkx181ek 296 31 plasticity plasticity NN cord-333986-xkx181ek 297 1 The the DT cord-333986-xkx181ek 297 2 EXPANd EXPANd NNS cord-333986-xkx181ek 297 3 trial trial NN cord-333986-xkx181ek 297 4 : : : cord-333986-xkx181ek 297 5 Effects effect NNS cord-333986-xkx181ek 297 6 of of IN cord-333986-xkx181ek 297 7 exercise exercise NN cord-333986-xkx181ek 297 8 and and CC cord-333986-xkx181ek 297 9 exploring explore VBG cord-333986-xkx181ek 297 10 neuroplastic neuroplastic JJ cord-333986-xkx181ek 297 11 changes change NNS cord-333986-xkx181ek 297 12 in in IN cord-333986-xkx181ek 297 13 people people NNS cord-333986-xkx181ek 297 14 with with IN cord-333986-xkx181ek 297 15 Parkinson Parkinson NNP cord-333986-xkx181ek 297 16 's 's POS cord-333986-xkx181ek 297 17 disease disease NN cord-333986-xkx181ek 297 18 : : : cord-333986-xkx181ek 298 1 A a DT cord-333986-xkx181ek 298 2 study study NN cord-333986-xkx181ek 298 3 protocol protocol NN cord-333986-xkx181ek 298 4 for for IN cord-333986-xkx181ek 298 5 a a DT cord-333986-xkx181ek 298 6 double double RB cord-333986-xkx181ek 298 7 - - HYPH cord-333986-xkx181ek 298 8 blinded blinded JJ cord-333986-xkx181ek 298 9 randomized randomized JJ cord-333986-xkx181ek 298 10 controlled control VBN cord-333986-xkx181ek 298 11 trial trial NN cord-333986-xkx181ek 298 12 Feasibility feasibility NN cord-333986-xkx181ek 298 13 Aspects aspect NNS cord-333986-xkx181ek 298 14 of of IN cord-333986-xkx181ek 298 15 Exploring explore VBG cord-333986-xkx181ek 298 16 Exercise exercise NN cord-333986-xkx181ek 298 17 - - HYPH cord-333986-xkx181ek 298 18 Induced induce VBN cord-333986-xkx181ek 298 19 Neuroplasticity Neuroplasticity NNP cord-333986-xkx181ek 298 20 in in IN cord-333986-xkx181ek 298 21 Parkinson Parkinson NNP cord-333986-xkx181ek 298 22 's 's POS cord-333986-xkx181ek 298 23 Disease Disease NNP cord-333986-xkx181ek 298 24 : : : cord-333986-xkx181ek 299 1 A a DT cord-333986-xkx181ek 299 2 Pilot Pilot NNP cord-333986-xkx181ek 299 3 Randomized Randomized NNP cord-333986-xkx181ek 299 4 Controlled Controlled NNP cord-333986-xkx181ek 299 5 Trial Trial NNP cord-333986-xkx181ek 299 6 Effects effect NNS cord-333986-xkx181ek 299 7 of of IN cord-333986-xkx181ek 299 8 high high JJ cord-333986-xkx181ek 299 9 intensity intensity NN cord-333986-xkx181ek 299 10 aerobic aerobic JJ cord-333986-xkx181ek 299 11 exercise exercise NN cord-333986-xkx181ek 299 12 on on IN cord-333986-xkx181ek 299 13 treadmill treadmill NN cord-333986-xkx181ek 299 14 on on IN cord-333986-xkx181ek 299 15 maximum maximum JJ cord-333986-xkx181ek 299 16 - - HYPH cord-333986-xkx181ek 299 17 expiratory expiratory JJ cord-333986-xkx181ek 299 18 lung lung NN cord-333986-xkx181ek 299 19 capacity capacity NN cord-333986-xkx181ek 299 20 of of IN cord-333986-xkx181ek 299 21 elderly elderly JJ cord-333986-xkx181ek 299 22 women woman NNS cord-333986-xkx181ek 300 1 The the DT cord-333986-xkx181ek 300 2 effects effect NNS cord-333986-xkx181ek 300 3 of of IN cord-333986-xkx181ek 300 4 aerobic aerobic JJ cord-333986-xkx181ek 300 5 training training NN cord-333986-xkx181ek 300 6 on on IN cord-333986-xkx181ek 300 7 respiratory respiratory JJ cord-333986-xkx181ek 300 8 muscle muscle NN cord-333986-xkx181ek 300 9 strength strength NN cord-333986-xkx181ek 300 10 and and CC cord-333986-xkx181ek 300 11 exercise exercise NN cord-333986-xkx181ek 300 12 capacity capacity NN cord-333986-xkx181ek 300 13 in in IN cord-333986-xkx181ek 300 14 ankylosing ankylose VBG cord-333986-xkx181ek 300 15 spondylitis spondylitis NN cord-333986-xkx181ek 300 16 patients patient NNS cord-333986-xkx181ek 300 17 Exercise Exercise NNP cord-333986-xkx181ek 300 18 Modulates modulate VBZ cord-333986-xkx181ek 300 19 Oxidative oxidative JJ cord-333986-xkx181ek 300 20 Stress stress NN cord-333986-xkx181ek 300 21 and and CC cord-333986-xkx181ek 300 22 Inflammation inflammation NN cord-333986-xkx181ek 300 23 in in IN cord-333986-xkx181ek 300 24 Aging age VBG cord-333986-xkx181ek 300 25 and and CC cord-333986-xkx181ek 300 26 Cardiovascular cardiovascular NN cord-333986-xkx181ek 301 1 Diseases disease NNS cord-333986-xkx181ek 301 2 Oxidative oxidative JJ cord-333986-xkx181ek 301 3 stress stress NN cord-333986-xkx181ek 301 4 : : : cord-333986-xkx181ek 302 1 Role role NN cord-333986-xkx181ek 302 2 of of IN cord-333986-xkx181ek 302 3 physical physical JJ cord-333986-xkx181ek 302 4 exercise exercise NN cord-333986-xkx181ek 302 5 and and CC cord-333986-xkx181ek 302 6 antioxidant antioxidant JJ cord-333986-xkx181ek 302 7 nutraceuticals nutraceutical NNS cord-333986-xkx181ek 302 8 in in IN cord-333986-xkx181ek 302 9 adulthood adulthood NN cord-333986-xkx181ek 302 10 and and CC cord-333986-xkx181ek 302 11 aging age VBG cord-333986-xkx181ek 302 12 Aerobic aerobic JJ cord-333986-xkx181ek 302 13 exercise exercise NN cord-333986-xkx181ek 302 14 attenuates attenuate VBZ cord-333986-xkx181ek 302 15 pulmonary pulmonary JJ cord-333986-xkx181ek 302 16 injury injury NN cord-333986-xkx181ek 302 17 induced induce VBN cord-333986-xkx181ek 302 18 by by IN cord-333986-xkx181ek 302 19 exposure exposure NN cord-333986-xkx181ek 302 20 to to IN cord-333986-xkx181ek 302 21 cigarette cigarette NN cord-333986-xkx181ek 302 22 smoke smoke NN cord-333986-xkx181ek 302 23 Extracellular Extracellular NNP cord-333986-xkx181ek 302 24 superoxide superoxide NN cord-333986-xkx181ek 302 25 dismutase dismutase NN cord-333986-xkx181ek 302 26 , , , cord-333986-xkx181ek 302 27 a a DT cord-333986-xkx181ek 302 28 molecular molecular JJ cord-333986-xkx181ek 302 29 transducer transducer NN cord-333986-xkx181ek 302 30 of of IN cord-333986-xkx181ek 302 31 health health NN cord-333986-xkx181ek 302 32 benefits benefit NNS cord-333986-xkx181ek 302 33 of of IN cord-333986-xkx181ek 302 34 exercise exercise NN cord-333986-xkx181ek 302 35 Exercise exercise NN cord-333986-xkx181ek 302 36 Training Training NNP cord-333986-xkx181ek 302 37 Protects protect VBZ cord-333986-xkx181ek 302 38 Against against IN cord-333986-xkx181ek 302 39 Acute acute JJ cord-333986-xkx181ek 302 40 Myocardial Myocardial NNP cord-333986-xkx181ek 302 41 Infarction Infarction NNP cord-333986-xkx181ek 302 42 via via IN cord-333986-xkx181ek 302 43 Improving improve VBG cord-333986-xkx181ek 302 44 Myocardial Myocardial NNP cord-333986-xkx181ek 302 45 Energy Energy NNP cord-333986-xkx181ek 302 46 Metabolism Metabolism NNP cord-333986-xkx181ek 302 47 and and CC cord-333986-xkx181ek 302 48 Mitochondrial Mitochondrial NNP cord-333986-xkx181ek 302 49 Biogenesis Biogenesis NNP cord-333986-xkx181ek 302 50 Resistance Resistance NNP cord-333986-xkx181ek 302 51 versus versus IN cord-333986-xkx181ek 302 52 aerobic aerobic JJ cord-333986-xkx181ek 302 53 exercise exercise NN cord-333986-xkx181ek 302 54 : : : cord-333986-xkx181ek 302 55 Acute acute JJ cord-333986-xkx181ek 302 56 effects effect NNS cord-333986-xkx181ek 302 57 on on IN cord-333986-xkx181ek 302 58 glycemia glycemia NN cord-333986-xkx181ek 302 59 in in IN cord-333986-xkx181ek 302 60 type type NN cord-333986-xkx181ek 302 61 1 1 CD cord-333986-xkx181ek 302 62 diabetes diabetes NN cord-333986-xkx181ek 302 63 Evidence evidence NN cord-333986-xkx181ek 302 64 for for IN cord-333986-xkx181ek 302 65 exercise exercise NN cord-333986-xkx181ek 302 66 training training NN cord-333986-xkx181ek 302 67 in in IN cord-333986-xkx181ek 302 68 the the DT cord-333986-xkx181ek 302 69 management management NN cord-333986-xkx181ek 302 70 of of IN cord-333986-xkx181ek 302 71 hypertension hypertension NN cord-333986-xkx181ek 302 72 in in IN cord-333986-xkx181ek 302 73 adults adult NNS cord-333986-xkx181ek 302 74 Physical Physical NNP cord-333986-xkx181ek 302 75 Activity Activity NNP cord-333986-xkx181ek 302 76 / / SYM cord-333986-xkx181ek 302 77 Exercise Exercise NNP cord-333986-xkx181ek 302 78 and and CC cord-333986-xkx181ek 302 79 Diabetes diabetes NN cord-333986-xkx181ek 302 80 : : : cord-333986-xkx181ek 303 1 A a DT cord-333986-xkx181ek 303 2 Position Position NNP cord-333986-xkx181ek 303 3 Statement Statement NNP cord-333986-xkx181ek 303 4 of of IN cord-333986-xkx181ek 303 5 the the DT cord-333986-xkx181ek 303 6 American American NNP cord-333986-xkx181ek 303 7 Diabetes Diabetes NNP cord-333986-xkx181ek 303 8 Association Association NNP cord-333986-xkx181ek 303 9 Aerobic Aerobic NNP cord-333986-xkx181ek 303 10 exercise exercise NN cord-333986-xkx181ek 303 11 reduces reduce VBZ cord-333986-xkx181ek 303 12 cardiomyocyte cardiomyocyte IN cord-333986-xkx181ek 303 13 hypertrophy hypertrophy NN cord-333986-xkx181ek 303 14 and and CC cord-333986-xkx181ek 303 15 increases increase VBZ cord-333986-xkx181ek 303 16 contractility contractility NN cord-333986-xkx181ek 303 17 , , , cord-333986-xkx181ek 303 18 Ca2 ca2 NN cord-333986-xkx181ek 303 19 + + CC cord-333986-xkx181ek 303 20 sensitivity sensitivity NN cord-333986-xkx181ek 303 21 and and CC cord-333986-xkx181ek 303 22 SERCA-2 SERCA-2 NNS cord-333986-xkx181ek 303 23 in in IN cord-333986-xkx181ek 303 24 rat rat NN cord-333986-xkx181ek 303 25 after after IN cord-333986-xkx181ek 303 26 myocardial myocardial JJ cord-333986-xkx181ek 303 27 infarction infarction NN cord-333986-xkx181ek 303 28 Frailty Frailty NNP cord-333986-xkx181ek 303 29 predicts predict VBZ cord-333986-xkx181ek 303 30 mortality mortality NN cord-333986-xkx181ek 303 31 in in IN cord-333986-xkx181ek 303 32 all all DT cord-333986-xkx181ek 303 33 emergency emergency NN cord-333986-xkx181ek 303 34 surgical surgical JJ cord-333986-xkx181ek 303 35 admissions admission NNS cord-333986-xkx181ek 303 36 regardless regardless RB cord-333986-xkx181ek 303 37 of of IN cord-333986-xkx181ek 303 38 age age NN cord-333986-xkx181ek 303 39 . . . cord-333986-xkx181ek 304 1 An an DT cord-333986-xkx181ek 304 2 observational observational JJ cord-333986-xkx181ek 304 3 study study NN cord-333986-xkx181ek 304 4 Multimorbidity Multimorbidity NNP cord-333986-xkx181ek 304 5 and and CC cord-333986-xkx181ek 304 6 Frailty Frailty NNP cord-333986-xkx181ek 304 7 : : : cord-333986-xkx181ek 304 8 Tackling tackle VBG cord-333986-xkx181ek 304 9 Complexity complexity NN cord-333986-xkx181ek 304 10 in in IN cord-333986-xkx181ek 304 11 Parkinson Parkinson NNP cord-333986-xkx181ek 304 12 's 's POS cord-333986-xkx181ek 304 13 Disease Disease NNP cord-333986-xkx181ek 304 14 . . . cord-333986-xkx181ek 305 1 J. J. NNP cord-333986-xkx181ek 305 2 Parkinson Parkinson NNP cord-333986-xkx181ek 305 3 's 's POS cord-333986-xkx181ek 305 4 Disease Disease NNP cord-333986-xkx181ek 305 5 2020 2020 CD cord-333986-xkx181ek 305 6 Physical physical JJ cord-333986-xkx181ek 305 7 exercise exercise NN cord-333986-xkx181ek 305 8 as as IN cord-333986-xkx181ek 305 9 therapy therapy NN cord-333986-xkx181ek 305 10 for for IN cord-333986-xkx181ek 305 11 frailty frailty NN cord-333986-xkx181ek 305 12 Frailty Frailty NNP cord-333986-xkx181ek 305 13 and and CC cord-333986-xkx181ek 305 14 exercise exercise NN cord-333986-xkx181ek 305 15 interventions intervention NNS cord-333986-xkx181ek 305 16 Low low JJ cord-333986-xkx181ek 305 17 - - HYPH cord-333986-xkx181ek 305 18 intensity intensity NN cord-333986-xkx181ek 305 19 exercise exercise NN cord-333986-xkx181ek 305 20 as as IN cord-333986-xkx181ek 305 21 a a DT cord-333986-xkx181ek 305 22 modifier modifier NN cord-333986-xkx181ek 305 23 of of IN cord-333986-xkx181ek 305 24 physical physical JJ cord-333986-xkx181ek 305 25 frailty frailty NN cord-333986-xkx181ek 305 26 in in IN cord-333986-xkx181ek 305 27 older old JJR cord-333986-xkx181ek 305 28 adults adult NNS cord-333986-xkx181ek 305 29 Effects effect NNS cord-333986-xkx181ek 305 30 of of IN cord-333986-xkx181ek 305 31 exercise exercise NN cord-333986-xkx181ek 305 32 training training NN cord-333986-xkx181ek 305 33 on on IN cord-333986-xkx181ek 305 34 frailty frailty NN cord-333986-xkx181ek 305 35 in in IN cord-333986-xkx181ek 305 36 community community NN cord-333986-xkx181ek 305 37 - - HYPH cord-333986-xkx181ek 305 38 dwelling dwell VBG cord-333986-xkx181ek 305 39 older old JJR cord-333986-xkx181ek 305 40 adults adult NNS cord-333986-xkx181ek 306 1 : : : cord-333986-xkx181ek 306 2 Results result NNS cord-333986-xkx181ek 306 3 of of IN cord-333986-xkx181ek 306 4 a a DT cord-333986-xkx181ek 306 5 randomized randomized JJ cord-333986-xkx181ek 306 6 , , , cord-333986-xkx181ek 306 7 controlled control VBN cord-333986-xkx181ek 306 8 trial trial NN cord-333986-xkx181ek 306 9 Istyniuk Istyniuk NNP cord-333986-xkx181ek 306 10 , , , cord-333986-xkx181ek 306 11 I. I. NNP cord-333986-xkx181ek 306 12 Effects effect NNS cord-333986-xkx181ek 306 13 of of IN cord-333986-xkx181ek 306 14 physical physical JJ cord-333986-xkx181ek 306 15 activity activity NN cord-333986-xkx181ek 306 16 on on IN cord-333986-xkx181ek 306 17 aging age VBG cord-333986-xkx181ek 306 18 processes process NNS cord-333986-xkx181ek 306 19 in in IN cord-333986-xkx181ek 306 20 elderly elderly JJ cord-333986-xkx181ek 306 21 persons person NNS cord-333986-xkx181ek 306 22 Physical physical JJ cord-333986-xkx181ek 306 23 activity activity NN cord-333986-xkx181ek 306 24 in in IN cord-333986-xkx181ek 306 25 older old JJR cord-333986-xkx181ek 306 26 age age NN cord-333986-xkx181ek 306 27 : : : cord-333986-xkx181ek 306 28 Perspectives perspective NNS cord-333986-xkx181ek 306 29 for for IN cord-333986-xkx181ek 306 30 healthy healthy JJ cord-333986-xkx181ek 306 31 ageing ageing NN cord-333986-xkx181ek 306 32 and and CC cord-333986-xkx181ek 306 33 frailty frailty NN cord-333986-xkx181ek 306 34 Health Health NNP cord-333986-xkx181ek 306 35 benefits benefit NNS cord-333986-xkx181ek 306 36 of of IN cord-333986-xkx181ek 306 37 physical physical JJ cord-333986-xkx181ek 306 38 activity activity NN cord-333986-xkx181ek 306 39 in in IN cord-333986-xkx181ek 306 40 older old JJR cord-333986-xkx181ek 306 41 patients patient NNS cord-333986-xkx181ek 306 42 : : : cord-333986-xkx181ek 306 43 A a DT cord-333986-xkx181ek 306 44 review review NN cord-333986-xkx181ek 306 45 Physical physical JJ cord-333986-xkx181ek 306 46 activity activity NN cord-333986-xkx181ek 306 47 in in IN cord-333986-xkx181ek 306 48 aging age VBG cord-333986-xkx181ek 306 49 : : : cord-333986-xkx181ek 306 50 Changes change NNS cord-333986-xkx181ek 306 51 in in IN cord-333986-xkx181ek 306 52 patterns pattern NNS cord-333986-xkx181ek 306 53 and and CC cord-333986-xkx181ek 306 54 their -PRON- PRP$ cord-333986-xkx181ek 306 55 relationship relationship NN cord-333986-xkx181ek 306 56 to to IN cord-333986-xkx181ek 306 57 health health NN cord-333986-xkx181ek 306 58 and and CC cord-333986-xkx181ek 306 59 function function VB cord-333986-xkx181ek 306 60 This this DT cord-333986-xkx181ek 306 61 article article NN cord-333986-xkx181ek 306 62 is be VBZ cord-333986-xkx181ek 306 63 an an DT cord-333986-xkx181ek 306 64 open open JJ cord-333986-xkx181ek 306 65 access access NN cord-333986-xkx181ek 306 66 article article NN cord-333986-xkx181ek 306 67 distributed distribute VBN cord-333986-xkx181ek 306 68 under under IN cord-333986-xkx181ek 306 69 the the DT cord-333986-xkx181ek 306 70 terms term NNS cord-333986-xkx181ek 306 71 and and CC cord-333986-xkx181ek 306 72 conditions condition NNS cord-333986-xkx181ek 306 73 of of IN cord-333986-xkx181ek 306 74 the the DT cord-333986-xkx181ek 306 75 Creative Creative NNP cord-333986-xkx181ek 306 76 Commons Commons NNP cord-333986-xkx181ek 306 77 Attribution Attribution NNP cord-333986-xkx181ek 306 78 ( ( -LRB- cord-333986-xkx181ek 306 79 CC CC NNP cord-333986-xkx181ek 306 80 BY by IN cord-333986-xkx181ek 306 81 ) ) -RRB- cord-333986-xkx181ek 306 82 license license NN cord-333986-xkx181ek 307 1 The the DT cord-333986-xkx181ek 307 2 authors author NNS cord-333986-xkx181ek 307 3 declare declare VBP cord-333986-xkx181ek 307 4 no no DT cord-333986-xkx181ek 307 5 conflict conflict NN cord-333986-xkx181ek 307 6 of of IN cord-333986-xkx181ek 307 7 interest interest NN cord-333986-xkx181ek 307 8 . . .