id sid tid token lemma pos cord-333164-1iiwhmkm 1 1 key key JJ cord-333164-1iiwhmkm 1 2 : : : cord-333164-1iiwhmkm 1 3 cord-333164 cord-333164 NNP cord-333164-1iiwhmkm 1 4 - - HYPH cord-333164-1iiwhmkm 1 5 1iiwhmkm 1iiwhmkm CD cord-333164-1iiwhmkm 1 6 authors author NNS cord-333164-1iiwhmkm 1 7 : : : cord-333164-1iiwhmkm 1 8 Singh Singh NNP cord-333164-1iiwhmkm 1 9 , , , cord-333164-1iiwhmkm 1 10 Awadhesh Awadhesh NNP cord-333164-1iiwhmkm 1 11 Kumar Kumar NNP cord-333164-1iiwhmkm 1 12 ; ; : cord-333164-1iiwhmkm 1 13 Gupta Gupta NNP cord-333164-1iiwhmkm 1 14 , , , cord-333164-1iiwhmkm 1 15 Ritesh Ritesh NNP cord-333164-1iiwhmkm 1 16 ; ; : cord-333164-1iiwhmkm 1 17 Misra Misra NNP cord-333164-1iiwhmkm 1 18 , , , cord-333164-1iiwhmkm 1 19 Anoop Anoop NNP cord-333164-1iiwhmkm 1 20 title title NN cord-333164-1iiwhmkm 1 21 : : : cord-333164-1iiwhmkm 2 1 Reply reply VB cord-333164-1iiwhmkm 2 2 to to IN cord-333164-1iiwhmkm 2 3 the the DT cord-333164-1iiwhmkm 2 4 Letter Letter NNP cord-333164-1iiwhmkm 2 5 of of IN cord-333164-1iiwhmkm 2 6 Mahajan Mahajan NNP cord-333164-1iiwhmkm 2 7 and and CC cord-333164-1iiwhmkm 2 8 Gaur Gaur NNP cord-333164-1iiwhmkm 2 9 in in IN cord-333164-1iiwhmkm 2 10 response response NN cord-333164-1iiwhmkm 2 11 to to IN cord-333164-1iiwhmkm 2 12 the the DT cord-333164-1iiwhmkm 2 13 article article NN cord-333164-1iiwhmkm 2 14 : : : cord-333164-1iiwhmkm 2 15 Comorbidities Comorbidities NNP cord-333164-1iiwhmkm 2 16 in in IN cord-333164-1iiwhmkm 2 17 COVID-19 COVID-19 NNP cord-333164-1iiwhmkm 2 18 : : : cord-333164-1iiwhmkm 2 19 outcomes outcome NNS cord-333164-1iiwhmkm 2 20 in in IN cord-333164-1iiwhmkm 2 21 hypertensive hypertensive JJ cord-333164-1iiwhmkm 2 22 cohort cohort NN cord-333164-1iiwhmkm 2 23 and and CC cord-333164-1iiwhmkm 2 24 controversies controversy NNS cord-333164-1iiwhmkm 2 25 with with IN cord-333164-1iiwhmkm 2 26 renin renin NN cord-333164-1iiwhmkm 2 27 angiotensin angiotensin NN cord-333164-1iiwhmkm 2 28 system system NN cord-333164-1iiwhmkm 2 29 blockers blocker NNS cord-333164-1iiwhmkm 2 30 ( ( -LRB- cord-333164-1iiwhmkm 2 31 Singh Singh NNP cord-333164-1iiwhmkm 2 32 et et NNP cord-333164-1iiwhmkm 2 33 al al NNP cord-333164-1iiwhmkm 2 34 . . . cord-333164-1iiwhmkm 2 35 ) ) -RRB- cord-333164-1iiwhmkm 3 1 date date NN cord-333164-1iiwhmkm 3 2 : : : cord-333164-1iiwhmkm 3 3 2020 2020 CD cord-333164-1iiwhmkm 3 4 - - HYPH cord-333164-1iiwhmkm 3 5 05 05 CD cord-333164-1iiwhmkm 3 6 - - HYPH cord-333164-1iiwhmkm 3 7 23 23 CD cord-333164-1iiwhmkm 3 8 journal journal NN cord-333164-1iiwhmkm 3 9 : : : cord-333164-1iiwhmkm 4 1 Diabetes diabetes NN cord-333164-1iiwhmkm 4 2 Metab Metab NNP cord-333164-1iiwhmkm 4 3 Syndr Syndr NNP cord-333164-1iiwhmkm 4 4 DOI DOI NNP cord-333164-1iiwhmkm 4 5 : : : cord-333164-1iiwhmkm 4 6 10.1016/ 10.1016/ CD cord-333164-1iiwhmkm 5 1 j.dsx.2020.05.030 j.dsx.2020.05.030 NNP cord-333164-1iiwhmkm 6 1 sha sha NNP cord-333164-1iiwhmkm 6 2 : : : cord-333164-1iiwhmkm 6 3 9bcb255e6f1f854a490bca4868176db67467e8a1 9bcb255e6f1f854a490bca4868176db67467e8a1 NNP cord-333164-1iiwhmkm 6 4 doc_id doc_id CD cord-333164-1iiwhmkm 6 5 : : : cord-333164-1iiwhmkm 6 6 333164 333164 CD cord-333164-1iiwhmkm 6 7 cord_uid cord_uid NNS cord-333164-1iiwhmkm 6 8 : : : cord-333164-1iiwhmkm 7 1 1iiwhmkm 1iiwhmkm LS cord-333164-1iiwhmkm 8 1 nan nan NNP cord-333164-1iiwhmkm 8 2 Reply Reply NNP cord-333164-1iiwhmkm 8 3 to to IN cord-333164-1iiwhmkm 8 4 the the DT cord-333164-1iiwhmkm 8 5 Letter Letter NNP cord-333164-1iiwhmkm 8 6 of of IN cord-333164-1iiwhmkm 8 7 Mahajan Mahajan NNP cord-333164-1iiwhmkm 8 8 and and CC cord-333164-1iiwhmkm 8 9 Gaur Gaur NNP cord-333164-1iiwhmkm 8 10 in in IN cord-333164-1iiwhmkm 8 11 response response NN cord-333164-1iiwhmkm 8 12 to to IN cord-333164-1iiwhmkm 8 13 the the DT cord-333164-1iiwhmkm 8 14 article article NN cord-333164-1iiwhmkm 8 15 : : : cord-333164-1iiwhmkm 8 16 Comorbidities Comorbidities NNP cord-333164-1iiwhmkm 8 17 in in IN cord-333164-1iiwhmkm 8 18 COVID-19 COVID-19 NNP cord-333164-1iiwhmkm 8 19 : : : cord-333164-1iiwhmkm 8 20 outcomes outcome NNS cord-333164-1iiwhmkm 8 21 in in IN cord-333164-1iiwhmkm 8 22 hypertensive hypertensive JJ cord-333164-1iiwhmkm 8 23 cohort cohort NN cord-333164-1iiwhmkm 8 24 and and CC cord-333164-1iiwhmkm 8 25 controversies controversy NNS cord-333164-1iiwhmkm 8 26 with with IN cord-333164-1iiwhmkm 8 27 renin renin NN cord-333164-1iiwhmkm 8 28 angiotensin angiotensin NN cord-333164-1iiwhmkm 8 29 system system NN cord-333164-1iiwhmkm 8 30 blockers blocker NNS cord-333164-1iiwhmkm 8 31 ( ( -LRB- cord-333164-1iiwhmkm 8 32 Singh Singh NNP cord-333164-1iiwhmkm 8 33 et et NNP cord-333164-1iiwhmkm 8 34 This this DT cord-333164-1iiwhmkm 8 35 is be VBZ cord-333164-1iiwhmkm 8 36 a a DT cord-333164-1iiwhmkm 8 37 PDF PDF NNP cord-333164-1iiwhmkm 8 38 file file NN cord-333164-1iiwhmkm 8 39 of of IN cord-333164-1iiwhmkm 8 40 an an DT cord-333164-1iiwhmkm 8 41 article article NN cord-333164-1iiwhmkm 8 42 that that WDT cord-333164-1iiwhmkm 8 43 has have VBZ cord-333164-1iiwhmkm 8 44 undergone undergo VBN cord-333164-1iiwhmkm 8 45 enhancements enhancement NNS cord-333164-1iiwhmkm 8 46 after after IN cord-333164-1iiwhmkm 8 47 acceptance acceptance NN cord-333164-1iiwhmkm 8 48 , , , cord-333164-1iiwhmkm 8 49 such such JJ cord-333164-1iiwhmkm 8 50 as as IN cord-333164-1iiwhmkm 8 51 the the DT cord-333164-1iiwhmkm 8 52 addition addition NN cord-333164-1iiwhmkm 8 53 of of IN cord-333164-1iiwhmkm 8 54 a a DT cord-333164-1iiwhmkm 8 55 cover cover NN cord-333164-1iiwhmkm 8 56 page page NN cord-333164-1iiwhmkm 8 57 and and CC cord-333164-1iiwhmkm 8 58 metadata metadata NN cord-333164-1iiwhmkm 8 59 , , , cord-333164-1iiwhmkm 8 60 and and CC cord-333164-1iiwhmkm 8 61 formatting format VBG cord-333164-1iiwhmkm 8 62 for for IN cord-333164-1iiwhmkm 8 63 readability readability NN cord-333164-1iiwhmkm 8 64 , , , cord-333164-1iiwhmkm 8 65 but but CC cord-333164-1iiwhmkm 8 66 it -PRON- PRP cord-333164-1iiwhmkm 8 67 is be VBZ cord-333164-1iiwhmkm 8 68 not not RB cord-333164-1iiwhmkm 8 69 yet yet RB cord-333164-1iiwhmkm 8 70 the the DT cord-333164-1iiwhmkm 8 71 definitive definitive JJ cord-333164-1iiwhmkm 8 72 version version NN cord-333164-1iiwhmkm 8 73 of of IN cord-333164-1iiwhmkm 8 74 record record NN cord-333164-1iiwhmkm 8 75 . . . cord-333164-1iiwhmkm 9 1 This this DT cord-333164-1iiwhmkm 9 2 version version NN cord-333164-1iiwhmkm 9 3 will will MD cord-333164-1iiwhmkm 9 4 undergo undergo VB cord-333164-1iiwhmkm 9 5 additional additional JJ cord-333164-1iiwhmkm 9 6 copyediting copyediting NN cord-333164-1iiwhmkm 9 7 , , , cord-333164-1iiwhmkm 9 8 typesetting typesetting NN cord-333164-1iiwhmkm 9 9 and and CC cord-333164-1iiwhmkm 9 10 review review NN cord-333164-1iiwhmkm 9 11 before before IN cord-333164-1iiwhmkm 9 12 it -PRON- PRP cord-333164-1iiwhmkm 9 13 is be VBZ cord-333164-1iiwhmkm 9 14 published publish VBN cord-333164-1iiwhmkm 9 15 in in IN cord-333164-1iiwhmkm 9 16 its -PRON- PRP$ cord-333164-1iiwhmkm 9 17 final final JJ cord-333164-1iiwhmkm 9 18 form form NN cord-333164-1iiwhmkm 9 19 , , , cord-333164-1iiwhmkm 9 20 but but CC cord-333164-1iiwhmkm 9 21 we -PRON- PRP cord-333164-1iiwhmkm 9 22 are be VBP cord-333164-1iiwhmkm 9 23 providing provide VBG cord-333164-1iiwhmkm 9 24 this this DT cord-333164-1iiwhmkm 9 25 version version NN cord-333164-1iiwhmkm 9 26 to to TO cord-333164-1iiwhmkm 9 27 give give VB cord-333164-1iiwhmkm 9 28 early early JJ cord-333164-1iiwhmkm 9 29 visibility visibility NN cord-333164-1iiwhmkm 9 30 of of IN cord-333164-1iiwhmkm 9 31 the the DT cord-333164-1iiwhmkm 9 32 article article NN cord-333164-1iiwhmkm 9 33 . . . cord-333164-1iiwhmkm 10 1 Please please UH cord-333164-1iiwhmkm 10 2 note note VB cord-333164-1iiwhmkm 10 3 that that IN cord-333164-1iiwhmkm 10 4 , , , cord-333164-1iiwhmkm 10 5 during during IN cord-333164-1iiwhmkm 10 6 the the DT cord-333164-1iiwhmkm 10 7 production production NN cord-333164-1iiwhmkm 10 8 process process NN cord-333164-1iiwhmkm 10 9 , , , cord-333164-1iiwhmkm 10 10 errors error NNS cord-333164-1iiwhmkm 10 11 may may MD cord-333164-1iiwhmkm 10 12 be be VB cord-333164-1iiwhmkm 10 13 discovered discover VBN cord-333164-1iiwhmkm 10 14 which which WDT cord-333164-1iiwhmkm 10 15 could could MD cord-333164-1iiwhmkm 10 16 affect affect VB cord-333164-1iiwhmkm 10 17 the the DT cord-333164-1iiwhmkm 10 18 content content NN cord-333164-1iiwhmkm 10 19 , , , cord-333164-1iiwhmkm 10 20 and and CC cord-333164-1iiwhmkm 10 21 all all DT cord-333164-1iiwhmkm 10 22 legal legal JJ cord-333164-1iiwhmkm 10 23 disclaimers disclaimer NNS cord-333164-1iiwhmkm 10 24 that that WDT cord-333164-1iiwhmkm 10 25 apply apply VBP cord-333164-1iiwhmkm 10 26 to to IN cord-333164-1iiwhmkm 10 27 the the DT cord-333164-1iiwhmkm 10 28 journal journal NN cord-333164-1iiwhmkm 10 29 pertain pertain VB cord-333164-1iiwhmkm 10 30 . . . cord-333164-1iiwhmkm 11 1 Comorbidities comorbiditie NNS cord-333164-1iiwhmkm 11 2 in in IN cord-333164-1iiwhmkm 11 3 COVID-19 COVID-19 NNP cord-333164-1iiwhmkm 11 4 : : : cord-333164-1iiwhmkm 11 5 outcomes outcome NNS cord-333164-1iiwhmkm 11 6 in in IN cord-333164-1iiwhmkm 11 7 hypertensive hypertensive JJ cord-333164-1iiwhmkm 11 8 cohort cohort NN cord-333164-1iiwhmkm 11 9 and and CC cord-333164-1iiwhmkm 11 10 controversies controversy NNS cord-333164-1iiwhmkm 11 11 with with IN cord-333164-1iiwhmkm 11 12 renin renin NN cord-333164-1iiwhmkm 11 13 angiotensin angiotensin NN cord-333164-1iiwhmkm 11 14 system system NN cord-333164-1iiwhmkm 11 15 blockers blocker NNS cord-333164-1iiwhmkm 11 16 ( ( -LRB- cord-333164-1iiwhmkm 11 17 Singh Singh NNP cord-333164-1iiwhmkm 11 18 et et NNP cord-333164-1iiwhmkm 11 19 al al NNP cord-333164-1iiwhmkm 11 20 . . . cord-333164-1iiwhmkm 11 21 ) ) -RRB- cord-333164-1iiwhmkm 11 22 . . . cord-333164-1iiwhmkm 12 1 Dear dear JJ cord-333164-1iiwhmkm 12 2 Sir Sir NNP cord-333164-1iiwhmkm 12 3 , , , cord-333164-1iiwhmkm 12 4 We -PRON- PRP cord-333164-1iiwhmkm 12 5 appreciate appreciate VBP cord-333164-1iiwhmkm 12 6 the the DT cord-333164-1iiwhmkm 12 7 keen keen JJ cord-333164-1iiwhmkm 12 8 interest interest NN cord-333164-1iiwhmkm 12 9 taken take VBN cord-333164-1iiwhmkm 12 10 by by IN cord-333164-1iiwhmkm 12 11 Drs Drs NNP cord-333164-1iiwhmkm 12 12 . . . cord-333164-1iiwhmkm 13 1 Mahajan Mahajan NNP cord-333164-1iiwhmkm 13 2 and and CC cord-333164-1iiwhmkm 13 3 Gaur Gaur NNP cord-333164-1iiwhmkm 13 4 for for IN cord-333164-1iiwhmkm 13 5 sending send VBG cord-333164-1iiwhmkm 13 6 a a DT cord-333164-1iiwhmkm 13 7 correspondence correspondence NN cord-333164-1iiwhmkm 13 8 in in IN cord-333164-1iiwhmkm 13 9 response response NN cord-333164-1iiwhmkm 13 10 to to IN cord-333164-1iiwhmkm 13 11 our -PRON- PRP$ cord-333164-1iiwhmkm 13 12 article article NN cord-333164-1iiwhmkm 13 13 titled title VBN cord-333164-1iiwhmkm 13 14 " " `` cord-333164-1iiwhmkm 13 15 Comorbidities Comorbidities NNPS cord-333164-1iiwhmkm 13 16 in in IN cord-333164-1iiwhmkm 13 17 COVID-19 COVID-19 NNP cord-333164-1iiwhmkm 13 18 : : : cord-333164-1iiwhmkm 13 19 outcomes outcome NNS cord-333164-1iiwhmkm 13 20 in in IN cord-333164-1iiwhmkm 13 21 hypertensive hypertensive JJ cord-333164-1iiwhmkm 13 22 cohort cohort NN cord-333164-1iiwhmkm 13 23 and and CC cord-333164-1iiwhmkm 13 24 controversies controversy NNS cord-333164-1iiwhmkm 13 25 with with IN cord-333164-1iiwhmkm 13 26 renin renin NN cord-333164-1iiwhmkm 13 27 angiotensin angiotensin NN cord-333164-1iiwhmkm 13 28 system system NN cord-333164-1iiwhmkm 13 29 blockers blocker NNS cord-333164-1iiwhmkm 13 30 " " '' cord-333164-1iiwhmkm 13 31 [ [ -LRB- cord-333164-1iiwhmkm 13 32 1 1 CD cord-333164-1iiwhmkm 13 33 ] ] -RRB- cord-333164-1iiwhmkm 13 34 . . . cord-333164-1iiwhmkm 14 1 Although although IN cord-333164-1iiwhmkm 14 2 the the DT cord-333164-1iiwhmkm 14 3 authors author NNS cord-333164-1iiwhmkm 14 4 are be VBP cord-333164-1iiwhmkm 14 5 in in IN cord-333164-1iiwhmkm 14 6 agreement agreement NN cord-333164-1iiwhmkm 14 7 with with IN cord-333164-1iiwhmkm 14 8 the the DT cord-333164-1iiwhmkm 14 9 findings finding NNS cord-333164-1iiwhmkm 14 10 in in IN cord-333164-1iiwhmkm 14 11 general general JJ cord-333164-1iiwhmkm 14 12 , , , cord-333164-1iiwhmkm 14 13 however however RB cord-333164-1iiwhmkm 14 14 they -PRON- PRP cord-333164-1iiwhmkm 14 15 have have VBP cord-333164-1iiwhmkm 14 16 raised raise VBN cord-333164-1iiwhmkm 14 17 two two CD cord-333164-1iiwhmkm 14 18 questions question NNS cord-333164-1iiwhmkm 14 19 in in IN cord-333164-1iiwhmkm 14 20 the the DT cord-333164-1iiwhmkm 14 21 correspondence correspondence NN cord-333164-1iiwhmkm 14 22 . . . cord-333164-1iiwhmkm 15 1 We -PRON- PRP cord-333164-1iiwhmkm 15 2 agree agree VBP cord-333164-1iiwhmkm 15 3 and and CC cord-333164-1iiwhmkm 15 4 that that DT cord-333164-1iiwhmkm 15 5 angiotensinconverting angiotensinconverting NN cord-333164-1iiwhmkm 15 6 enzyme enzyme NN cord-333164-1iiwhmkm 15 7 inhibitors inhibitor NNS cord-333164-1iiwhmkm 15 8 do do VBP cord-333164-1iiwhmkm 15 9 not not RB cord-333164-1iiwhmkm 15 10 increase increase VB cord-333164-1iiwhmkm 15 11 angiotensin angiotensin NN cord-333164-1iiwhmkm 15 12 II II NNP cord-333164-1iiwhmkm 15 13 , , , cord-333164-1iiwhmkm 15 14 while while IN cord-333164-1iiwhmkm 15 15 angiotensinreceptor angiotensinreceptor NN cord-333164-1iiwhmkm 15 16 blockers blocker NNS cord-333164-1iiwhmkm 15 17 have have VBP cord-333164-1iiwhmkm 15 18 the the DT cord-333164-1iiwhmkm 15 19 potential potential NN cord-333164-1iiwhmkm 15 20 to to TO cord-333164-1iiwhmkm 15 21 increase increase VB cord-333164-1iiwhmkm 15 22 it -PRON- PRP cord-333164-1iiwhmkm 15 23 . . . cord-333164-1iiwhmkm 16 1 However however RB cord-333164-1iiwhmkm 16 2 , , , cord-333164-1iiwhmkm 16 3 the the DT cord-333164-1iiwhmkm 16 4 hypothesis hypothesis NN cord-333164-1iiwhmkm 16 5 that that IN cord-333164-1iiwhmkm 16 6 the the DT cord-333164-1iiwhmkm 16 7 interaction interaction NN cord-333164-1iiwhmkm 16 8 of of IN cord-333164-1iiwhmkm 16 9 angiotensin angiotensin NN cord-333164-1iiwhmkm 16 10 converting convert VBG cord-333164-1iiwhmkm 16 11 enzyme-2 enzyme-2 NNP cord-333164-1iiwhmkm 16 12 ( ( -LRB- cord-333164-1iiwhmkm 16 13 ACE-2 ACE-2 NNP cord-333164-1iiwhmkm 16 14 ) ) -RRB- cord-333164-1iiwhmkm 16 15 with with IN cord-333164-1iiwhmkm 16 16 angiotensin angiotensin NN cord-333164-1iiwhmkm 16 17 II II NNP cord-333164-1iiwhmkm 16 18 could could MD cord-333164-1iiwhmkm 16 19 lead lead VB cord-333164-1iiwhmkm 16 20 to to IN cord-333164-1iiwhmkm 16 21 a a DT cord-333164-1iiwhmkm 16 22 conformational conformational JJ cord-333164-1iiwhmkm 16 23 change change NN cord-333164-1iiwhmkm 16 24 in in IN cord-333164-1iiwhmkm 16 25 the the DT cord-333164-1iiwhmkm 16 26 receptor receptor NN cord-333164-1iiwhmkm 16 27 binding bind VBG cord-333164-1iiwhmkm 16 28 domain domain NN cord-333164-1iiwhmkm 16 29 of of IN cord-333164-1iiwhmkm 16 30 ACE2 ACE2 NNP cord-333164-1iiwhmkm 16 31 is be VBZ cord-333164-1iiwhmkm 16 32 not not RB cord-333164-1iiwhmkm 16 33 unfounded unfounded JJ cord-333164-1iiwhmkm 16 34 and and CC cord-333164-1iiwhmkm 16 35 has have VBZ cord-333164-1iiwhmkm 16 36 been be VBN cord-333164-1iiwhmkm 16 37 put put VBN cord-333164-1iiwhmkm 16 38 forth forth RP cord-333164-1iiwhmkm 16 39 in in IN cord-333164-1iiwhmkm 16 40 the the DT cord-333164-1iiwhmkm 16 41 study study NN cord-333164-1iiwhmkm 16 42 on on IN cord-333164-1iiwhmkm 16 43 the the DT cord-333164-1iiwhmkm 16 44 X X NNP cord-333164-1iiwhmkm 16 45 - - NNP cord-333164-1iiwhmkm 16 46 Ray Ray NNP cord-333164-1iiwhmkm 16 47 structure structure NN cord-333164-1iiwhmkm 16 48 of of IN cord-333164-1iiwhmkm 16 49 ACE-2 ACE-2 NNP cord-333164-1iiwhmkm 16 50 [ [ -LRB- cord-333164-1iiwhmkm 16 51 2 2 CD cord-333164-1iiwhmkm 16 52 ] ] -RRB- cord-333164-1iiwhmkm 16 53 . . . cord-333164-1iiwhmkm 17 1 With with IN cord-333164-1iiwhmkm 17 2 regards regard NNS cord-333164-1iiwhmkm 17 3 to to IN cord-333164-1iiwhmkm 17 4 other other JJ cord-333164-1iiwhmkm 17 5 query query NN cord-333164-1iiwhmkm 17 6 about about IN cord-333164-1iiwhmkm 17 7 the the DT cord-333164-1iiwhmkm 17 8 purported purport VBN cord-333164-1iiwhmkm 17 9 protection protection NN cord-333164-1iiwhmkm 17 10 of of IN cord-333164-1iiwhmkm 17 11 lung lung NN cord-333164-1iiwhmkm 17 12 injury injury NN cord-333164-1iiwhmkm 17 13 by by IN cord-333164-1iiwhmkm 17 14 the the DT cord-333164-1iiwhmkm 17 15 renin renin NN cord-333164-1iiwhmkm 17 16 angiotensin angiotensin NNP cord-333164-1iiwhmkm 17 17 system system NN cord-333164-1iiwhmkm 17 18 blockers(RASBs blockers(rasb NNS cord-333164-1iiwhmkm 17 19 ) ) -RRB- cord-333164-1iiwhmkm 17 20 , , , cord-333164-1iiwhmkm 17 21 we -PRON- PRP cord-333164-1iiwhmkm 17 22 humbly humbly RB cord-333164-1iiwhmkm 17 23 inform inform VBP cord-333164-1iiwhmkm 17 24 that that IN cord-333164-1iiwhmkm 17 25 it -PRON- PRP cord-333164-1iiwhmkm 17 26 has have VBZ cord-333164-1iiwhmkm 17 27 already already RB cord-333164-1iiwhmkm 17 28 been be VBN cord-333164-1iiwhmkm 17 29 dealt deal VBN cord-333164-1iiwhmkm 17 30 with with IN cord-333164-1iiwhmkm 17 31 a a DT cord-333164-1iiwhmkm 17 32 great great JJ cord-333164-1iiwhmkm 17 33 detail detail NN cord-333164-1iiwhmkm 17 34 , , , cord-333164-1iiwhmkm 17 35 which which WDT cord-333164-1iiwhmkm 17 36 authors author NNS cord-333164-1iiwhmkm 17 37 seems seem VBZ cord-333164-1iiwhmkm 17 38 to to TO cord-333164-1iiwhmkm 17 39 have have VB cord-333164-1iiwhmkm 17 40 overlooked overlook VBN cord-333164-1iiwhmkm 17 41 . . . cord-333164-1iiwhmkm 18 1 Similarly similarly RB cord-333164-1iiwhmkm 18 2 , , , cord-333164-1iiwhmkm 18 3 the the DT cord-333164-1iiwhmkm 18 4 figures figure NNS cord-333164-1iiwhmkm 18 5 in in IN cord-333164-1iiwhmkm 18 6 our -PRON- PRP$ cord-333164-1iiwhmkm 18 7 article article NN cord-333164-1iiwhmkm 18 8 has have VBZ cord-333164-1iiwhmkm 18 9 much much RB cord-333164-1iiwhmkm 18 10 more more RBR cord-333164-1iiwhmkm 18 11 detailed detailed JJ cord-333164-1iiwhmkm 18 12 information information NN cord-333164-1iiwhmkm 18 13 on on IN cord-333164-1iiwhmkm 18 14 the the DT cord-333164-1iiwhmkm 18 15 interaction interaction NN cord-333164-1iiwhmkm 18 16 of of IN cord-333164-1iiwhmkm 18 17 renin renin NN cord-333164-1iiwhmkm 18 18 angiotensin angiotensin NN cord-333164-1iiwhmkm 18 19 system system NN cord-333164-1iiwhmkm 18 20 blockers blocker NNS cord-333164-1iiwhmkm 18 21 ( ( -LRB- cord-333164-1iiwhmkm 18 22 RASB RASB NNP cord-333164-1iiwhmkm 18 23 ) ) -RRB- cord-333164-1iiwhmkm 18 24 , , , cord-333164-1iiwhmkm 18 25 ACE-2 ACE-2 NNP cord-333164-1iiwhmkm 18 26 and and CC cord-333164-1iiwhmkm 18 27 coronavirus coronavirus NN cord-333164-1iiwhmkm 18 28 infectious infectious JJ cord-333164-1iiwhmkm 18 29 disease disease NN cord-333164-1iiwhmkm 18 30 2019 2019 CD cord-333164-1iiwhmkm 18 31 ( ( -LRB- cord-333164-1iiwhmkm 18 32 COVID-19 COVID-19 NNP cord-333164-1iiwhmkm 18 33 ) ) -RRB- cord-333164-1iiwhmkm 18 34 . . . cord-333164-1iiwhmkm 19 1 We -PRON- PRP cord-333164-1iiwhmkm 19 2 would would MD cord-333164-1iiwhmkm 19 3 like like VB cord-333164-1iiwhmkm 19 4 to to TO cord-333164-1iiwhmkm 19 5 reiterate reiterate VB cord-333164-1iiwhmkm 19 6 again again RB cord-333164-1iiwhmkm 19 7 , , , cord-333164-1iiwhmkm 19 8 that that IN cord-333164-1iiwhmkm 19 9 the the DT cord-333164-1iiwhmkm 19 10 benefit benefit NN cord-333164-1iiwhmkm 19 11 or or CC cord-333164-1iiwhmkm 19 12 harm harm NN cord-333164-1iiwhmkm 19 13 with with IN cord-333164-1iiwhmkm 19 14 RASBs rasb NNS cord-333164-1iiwhmkm 19 15 in in IN cord-333164-1iiwhmkm 19 16 COVID-19 COVID-19 NNP cord-333164-1iiwhmkm 19 17 is be VBZ cord-333164-1iiwhmkm 19 18 still still RB cord-333164-1iiwhmkm 19 19 a a DT cord-333164-1iiwhmkm 19 20 subject subject NN cord-333164-1iiwhmkm 19 21 of of IN cord-333164-1iiwhmkm 19 22 debate debate NN cord-333164-1iiwhmkm 19 23 and and CC cord-333164-1iiwhmkm 19 24 data datum NNS cord-333164-1iiwhmkm 19 25 at at IN cord-333164-1iiwhmkm 19 26 this this DT cord-333164-1iiwhmkm 19 27 point point NN cord-333164-1iiwhmkm 19 28 of of IN cord-333164-1iiwhmkm 19 29 time time NN cord-333164-1iiwhmkm 19 30 suggest suggest VBP cord-333164-1iiwhmkm 19 31 a a DT cord-333164-1iiwhmkm 19 32 clinical clinical JJ cord-333164-1iiwhmkm 19 33 equipoise equipoise NN cord-333164-1iiwhmkm 19 34 . . . cord-333164-1iiwhmkm 20 1 Some some DT cord-333164-1iiwhmkm 20 2 studies study NNS cord-333164-1iiwhmkm 20 3 have have VBP cord-333164-1iiwhmkm 20 4 shown show VBN cord-333164-1iiwhmkm 20 5 a a DT cord-333164-1iiwhmkm 20 6 purported purported JJ cord-333164-1iiwhmkm 20 7 harm harm NN cord-333164-1iiwhmkm 20 8 [ [ -LRB- cord-333164-1iiwhmkm 20 9 3 3 CD cord-333164-1iiwhmkm 20 10 , , , cord-333164-1iiwhmkm 20 11 4 4 CD cord-333164-1iiwhmkm 20 12 ] ] -RRB- cord-333164-1iiwhmkm 20 13 , , , cord-333164-1iiwhmkm 20 14 while while IN cord-333164-1iiwhmkm 20 15 some some DT cord-333164-1iiwhmkm 20 16 others other NNS cord-333164-1iiwhmkm 20 17 have have VBP cord-333164-1iiwhmkm 20 18 shown show VBN cord-333164-1iiwhmkm 20 19 benefit benefit VB cord-333164-1iiwhmkm 20 20 [ [ -LRB- cord-333164-1iiwhmkm 20 21 5 5 CD cord-333164-1iiwhmkm 20 22 ] ] -RRB- cord-333164-1iiwhmkm 20 23 ; ; : cord-333164-1iiwhmkm 20 24 the the DT cord-333164-1iiwhmkm 20 25 reason reason NN cord-333164-1iiwhmkm 20 26 why why WRB cord-333164-1iiwhmkm 20 27 we -PRON- PRP cord-333164-1iiwhmkm 20 28 discussed discuss VBD cord-333164-1iiwhmkm 20 29 both both PDT cord-333164-1iiwhmkm 20 30 these these DT cord-333164-1iiwhmkm 20 31 issues issue NNS cord-333164-1iiwhmkm 20 32 in in IN cord-333164-1iiwhmkm 20 33 detail detail NN cord-333164-1iiwhmkm 20 34 . . . cord-333164-1iiwhmkm 21 1 However however RB cord-333164-1iiwhmkm 21 2 , , , cord-333164-1iiwhmkm 21 3 we -PRON- PRP cord-333164-1iiwhmkm 21 4 do do VBP cord-333164-1iiwhmkm 21 5 not not RB cord-333164-1iiwhmkm 21 6 recommend recommend VB cord-333164-1iiwhmkm 21 7 to to TO cord-333164-1iiwhmkm 21 8 stop stop VB cord-333164-1iiwhmkm 21 9 the the DT cord-333164-1iiwhmkm 21 10 RASB RASB NNP cord-333164-1iiwhmkm 21 11 in in IN cord-333164-1iiwhmkm 21 12 patient patient NN cord-333164-1iiwhmkm 21 13 with with IN cord-333164-1iiwhmkm 21 14 COVID-19 COVID-19 NNP cord-333164-1iiwhmkm 21 15 . . . cord-333164-1iiwhmkm 22 1 Ritesh Ritesh NNP cord-333164-1iiwhmkm 22 2 Gupta Gupta NNP cord-333164-1iiwhmkm 22 3 Anoop Anoop NNP cord-333164-1iiwhmkm 22 4 Misra Misra NNP cord-333164-1iiwhmkm 22 5 Comorbidities Comorbidities NNP cord-333164-1iiwhmkm 22 6 in in IN cord-333164-1iiwhmkm 22 7 COVID-19 COVID-19 NNP cord-333164-1iiwhmkm 22 8 : : : cord-333164-1iiwhmkm 22 9 outcomes outcome NNS cord-333164-1iiwhmkm 22 10 in in IN cord-333164-1iiwhmkm 22 11 hypertensivecohort hypertensivecohort NN cord-333164-1iiwhmkm 22 12 and and CC cord-333164-1iiwhmkm 22 13 controversies controversy NNS cord-333164-1iiwhmkm 22 14 with with IN cord-333164-1iiwhmkm 22 15 renin renin NN cord-333164-1iiwhmkm 22 16 angiotensin angiotensin NN cord-333164-1iiwhmkm 22 17 system system NN cord-333164-1iiwhmkm 22 18 blockers blocker VBZ cord-333164-1iiwhmkm 22 19 ACE2 ACE2 NNP cord-333164-1iiwhmkm 22 20 X x NN cord-333164-1iiwhmkm 22 21 - - NN cord-333164-1iiwhmkm 22 22 ray ray NN cord-333164-1iiwhmkm 22 23 structures structure NNS cord-333164-1iiwhmkm 22 24 reveal reveal VBP cord-333164-1iiwhmkm 22 25 a a DT cord-333164-1iiwhmkm 22 26 large large JJ cord-333164-1iiwhmkm 22 27 hinge hinge NN cord-333164-1iiwhmkm 22 28 - - HYPH cord-333164-1iiwhmkm 22 29 bending bend VBG cord-333164-1iiwhmkm 22 30 motion motion NN cord-333164-1iiwhmkm 22 31 important important JJ cord-333164-1iiwhmkm 22 32 for for IN cord-333164-1iiwhmkm 22 33 inhibitor inhibitor NN cord-333164-1iiwhmkm 22 34 binding binding NN cord-333164-1iiwhmkm 22 35 and and CC cord-333164-1iiwhmkm 22 36 catalysis catalysis NN cord-333164-1iiwhmkm 22 37 Cardiovascular cardiovascular JJ cord-333164-1iiwhmkm 22 38 Implications implication NNS cord-333164-1iiwhmkm 22 39 of of IN cord-333164-1iiwhmkm 22 40 Fatal fatal JJ cord-333164-1iiwhmkm 22 41 Outcomes Outcomes NNPS cord-333164-1iiwhmkm 22 42 of of IN cord-333164-1iiwhmkm 22 43 Patients patient NNS cord-333164-1iiwhmkm 23 1 With with IN cord-333164-1iiwhmkm 23 2 Coronavirus Coronavirus NNP cord-333164-1iiwhmkm 23 3 Disease Disease NNP cord-333164-1iiwhmkm 24 1 COVID-19 covid-19 LS cord-333164-1iiwhmkm 24 2 ) ) -RRB- cord-333164-1iiwhmkm 25 1 Early early JJ cord-333164-1iiwhmkm 25 2 treatment treatment NN cord-333164-1iiwhmkm 25 3 of of IN cord-333164-1iiwhmkm 25 4 1061 1061 CD cord-333164-1iiwhmkm 26 1 COVID-19 covid-19 JJ cord-333164-1iiwhmkm 26 2 patients patient NNS cord-333164-1iiwhmkm 26 3 with with IN cord-333164-1iiwhmkm 26 4 hydroxychloroquine hydroxychloroquine NNP cord-333164-1iiwhmkm 26 5 and and CC cord-333164-1iiwhmkm 26 6 azithromycin azithromycin NNP cord-333164-1iiwhmkm 26 7 Association Association NNP cord-333164-1iiwhmkm 26 8 of of IN cord-333164-1iiwhmkm 26 9 Inpatient Inpatient NNP cord-333164-1iiwhmkm 26 10 Use Use NNP cord-333164-1iiwhmkm 26 11 of of IN cord-333164-1iiwhmkm 26 12 Angiotensin Angiotensin NNP cord-333164-1iiwhmkm 26 13 Converting Converting NNP cord-333164-1iiwhmkm 26 14 Enzyme Enzyme NNP cord-333164-1iiwhmkm 26 15 Inhibitors Inhibitors NNP cord-333164-1iiwhmkm 26 16 and and CC cord-333164-1iiwhmkm 26 17 Angiotensin Angiotensin NNP cord-333164-1iiwhmkm 26 18 II II NNP cord-333164-1iiwhmkm 26 19 Receptor Receptor NNP cord-333164-1iiwhmkm 26 20 Blockers Blockers NNP cord-333164-1iiwhmkm 26 21 with with IN cord-333164-1iiwhmkm 26 22 Mortality mortality NN cord-333164-1iiwhmkm 26 23 Among among IN cord-333164-1iiwhmkm 26 24 Patients patient NNS cord-333164-1iiwhmkm 26 25 With with IN cord-333164-1iiwhmkm 26 26 Hypertension hypertension NN cord-333164-1iiwhmkm 26 27 Hospitalized hospitalize VBN cord-333164-1iiwhmkm 26 28 With with IN cord-333164-1iiwhmkm 26 29 COVID-19 covid-19 NN