id sid tid token lemma pos cord-328352-l1q4uvxl 1 1 key key NN cord-328352-l1q4uvxl 1 2 : : : cord-328352-l1q4uvxl 1 3 cord-328352-l1q4uvxl cord-328352-l1q4uvxl NFP cord-328352-l1q4uvxl 1 4 authors author NNS cord-328352-l1q4uvxl 1 5 : : : cord-328352-l1q4uvxl 1 6 Borlongan Borlongan NNP cord-328352-l1q4uvxl 1 7 , , , cord-328352-l1q4uvxl 1 8 Mia Mia NNP cord-328352-l1q4uvxl 1 9 C. C. NNP cord-328352-l1q4uvxl 1 10 ; ; : cord-328352-l1q4uvxl 1 11 Borlongan Borlongan NNP cord-328352-l1q4uvxl 1 12 , , , cord-328352-l1q4uvxl 1 13 Maximillian Maximillian NNP cord-328352-l1q4uvxl 1 14 C. C. NNP cord-328352-l1q4uvxl 1 15 ; ; : cord-328352-l1q4uvxl 1 16 Sanberg Sanberg NNP cord-328352-l1q4uvxl 1 17 , , , cord-328352-l1q4uvxl 1 18 Paul Paul NNP cord-328352-l1q4uvxl 1 19 R. R. NNP cord-328352-l1q4uvxl 1 20 title title NN cord-328352-l1q4uvxl 1 21 : : : cord-328352-l1q4uvxl 1 22 The the DT cord-328352-l1q4uvxl 1 23 Disillusioned Disillusioned NNP cord-328352-l1q4uvxl 1 24 Comfort Comfort NNP cord-328352-l1q4uvxl 1 25 with with IN cord-328352-l1q4uvxl 1 26 COVID-19 COVID-19 NNP cord-328352-l1q4uvxl 1 27 and and CC cord-328352-l1q4uvxl 1 28 the the DT cord-328352-l1q4uvxl 1 29 Potential potential NN cord-328352-l1q4uvxl 1 30 of of IN cord-328352-l1q4uvxl 1 31 Convalescent Convalescent NNP cord-328352-l1q4uvxl 1 32 Plasma Plasma NNP cord-328352-l1q4uvxl 1 33 and and CC cord-328352-l1q4uvxl 1 34 Cell Cell NNP cord-328352-l1q4uvxl 1 35 Therapy Therapy NNP cord-328352-l1q4uvxl 1 36 date date NN cord-328352-l1q4uvxl 1 37 : : : cord-328352-l1q4uvxl 1 38 2020 2020 CD cord-328352-l1q4uvxl 1 39 - - HYPH cord-328352-l1q4uvxl 1 40 08 08 CD cord-328352-l1q4uvxl 1 41 - - SYM cord-328352-l1q4uvxl 1 42 25 25 CD cord-328352-l1q4uvxl 1 43 journal journal NN cord-328352-l1q4uvxl 1 44 : : : cord-328352-l1q4uvxl 2 1 Cell cell NN cord-328352-l1q4uvxl 2 2 Transplant transplant NN cord-328352-l1q4uvxl 2 3 DOI doi NN cord-328352-l1q4uvxl 2 4 : : : cord-328352-l1q4uvxl 2 5 10.1177/0963689720940719 10.1177/0963689720940719 CD cord-328352-l1q4uvxl 2 6 sha sha NN cord-328352-l1q4uvxl 2 7 : : : cord-328352-l1q4uvxl 3 1 5c2cede17c25750ef19ccefb6c2f91bf4efb1501 5c2cede17c25750ef19ccefb6c2f91bf4efb1501 CD cord-328352-l1q4uvxl 3 2 doc_id doc_id CD cord-328352-l1q4uvxl 3 3 : : : cord-328352-l1q4uvxl 3 4 328352 328352 CD cord-328352-l1q4uvxl 3 5 cord_uid cord_uid NNS cord-328352-l1q4uvxl 3 6 : : : cord-328352-l1q4uvxl 4 1 l1q4uvxl l1q4uvxl . cord-328352-l1q4uvxl 5 1 Coronavirus Coronavirus NNP cord-328352-l1q4uvxl 5 2 disease disease NN cord-328352-l1q4uvxl 5 3 2019 2019 CD cord-328352-l1q4uvxl 5 4 or or CC cord-328352-l1q4uvxl 5 5 COVID-19 covid-19 NN cord-328352-l1q4uvxl 5 6 is be VBZ cord-328352-l1q4uvxl 5 7 highly highly RB cord-328352-l1q4uvxl 5 8 infectious infectious JJ cord-328352-l1q4uvxl 5 9 , , , cord-328352-l1q4uvxl 5 10 which which WDT cord-328352-l1q4uvxl 5 11 can can MD cord-328352-l1q4uvxl 5 12 lead lead VB cord-328352-l1q4uvxl 5 13 to to IN cord-328352-l1q4uvxl 5 14 acute acute JJ cord-328352-l1q4uvxl 5 15 and and CC cord-328352-l1q4uvxl 5 16 chronic chronic JJ cord-328352-l1q4uvxl 5 17 debilitating debilitating JJ cord-328352-l1q4uvxl 5 18 symptoms symptom NNS cord-328352-l1q4uvxl 5 19 , , , cord-328352-l1q4uvxl 5 20 as as RB cord-328352-l1q4uvxl 5 21 well well RB cord-328352-l1q4uvxl 5 22 as as IN cord-328352-l1q4uvxl 5 23 mortality mortality NN cord-328352-l1q4uvxl 5 24 . . . cord-328352-l1q4uvxl 6 1 The the DT cord-328352-l1q4uvxl 6 2 advent advent NN cord-328352-l1q4uvxl 6 3 of of IN cord-328352-l1q4uvxl 6 4 safe safe JJ cord-328352-l1q4uvxl 6 5 and and CC cord-328352-l1q4uvxl 6 6 effective effective JJ cord-328352-l1q4uvxl 6 7 vaccines vaccine NNS cord-328352-l1q4uvxl 6 8 or or CC cord-328352-l1q4uvxl 6 9 antiviral antiviral JJ cord-328352-l1q4uvxl 6 10 drugs drug NNS cord-328352-l1q4uvxl 6 11 remains remain VBZ cord-328352-l1q4uvxl 6 12 distant distant JJ cord-328352-l1q4uvxl 6 13 in in IN cord-328352-l1q4uvxl 6 14 the the DT cord-328352-l1q4uvxl 6 15 future future NN cord-328352-l1q4uvxl 6 16 . . . cord-328352-l1q4uvxl 7 1 Practical practical JJ cord-328352-l1q4uvxl 7 2 public public JJ cord-328352-l1q4uvxl 7 3 health health NN cord-328352-l1q4uvxl 7 4 measures measure NNS cord-328352-l1q4uvxl 7 5 , , , cord-328352-l1q4uvxl 7 6 such such JJ cord-328352-l1q4uvxl 7 7 as as IN cord-328352-l1q4uvxl 7 8 social social JJ cord-328352-l1q4uvxl 7 9 distancing distancing NN cord-328352-l1q4uvxl 7 10 , , , cord-328352-l1q4uvxl 7 11 hand hand NN cord-328352-l1q4uvxl 7 12 washing washing NN cord-328352-l1q4uvxl 7 13 , , , cord-328352-l1q4uvxl 7 14 and and CC cord-328352-l1q4uvxl 7 15 wearing wear VBG cord-328352-l1q4uvxl 7 16 a a DT cord-328352-l1q4uvxl 7 17 face face NN cord-328352-l1q4uvxl 7 18 mask mask NN cord-328352-l1q4uvxl 7 19 , , , cord-328352-l1q4uvxl 7 20 are be VBP cord-328352-l1q4uvxl 7 21 the the DT cord-328352-l1q4uvxl 7 22 current current JJ cord-328352-l1q4uvxl 7 23 recommended recommend VBN cord-328352-l1q4uvxl 7 24 guidelines guideline NNS cord-328352-l1q4uvxl 7 25 by by IN cord-328352-l1q4uvxl 7 26 the the DT cord-328352-l1q4uvxl 7 27 Centers Centers NNPS cord-328352-l1q4uvxl 7 28 for for IN cord-328352-l1q4uvxl 7 29 Disease Disease NNP cord-328352-l1q4uvxl 7 30 Control Control NNP cord-328352-l1q4uvxl 7 31 and and CC cord-328352-l1q4uvxl 7 32 Prevention Prevention NNP cord-328352-l1q4uvxl 7 33 for for IN cord-328352-l1q4uvxl 7 34 limiting limit VBG cord-328352-l1q4uvxl 7 35 the the DT cord-328352-l1q4uvxl 7 36 spread spread NN cord-328352-l1q4uvxl 7 37 of of IN cord-328352-l1q4uvxl 7 38 the the DT cord-328352-l1q4uvxl 7 39 virus virus NN cord-328352-l1q4uvxl 7 40 . . . cord-328352-l1q4uvxl 8 1 Weakened weakened JJ cord-328352-l1q4uvxl 8 2 immune immune JJ cord-328352-l1q4uvxl 8 3 system system NN cord-328352-l1q4uvxl 8 4 and and CC cord-328352-l1q4uvxl 8 5 aberrant aberrant JJ cord-328352-l1q4uvxl 8 6 inflammation inflammation NN cord-328352-l1q4uvxl 8 7 represent represent VBP cord-328352-l1q4uvxl 8 8 a a DT cord-328352-l1q4uvxl 8 9 major major JJ cord-328352-l1q4uvxl 8 10 pathological pathological JJ cord-328352-l1q4uvxl 8 11 symptom symptom NN cord-328352-l1q4uvxl 8 12 of of IN cord-328352-l1q4uvxl 8 13 COVID-19 covid-19 JJ cord-328352-l1q4uvxl 8 14 patients patient NNS cord-328352-l1q4uvxl 8 15 . . . cord-328352-l1q4uvxl 9 1 Based base VBN cord-328352-l1q4uvxl 9 2 on on IN cord-328352-l1q4uvxl 9 3 the the DT cord-328352-l1q4uvxl 9 4 unique unique JJ cord-328352-l1q4uvxl 9 5 immunomodulatory immunomodulatory JJ cord-328352-l1q4uvxl 9 6 properties property NNS cord-328352-l1q4uvxl 9 7 of of IN cord-328352-l1q4uvxl 9 8 both both DT cord-328352-l1q4uvxl 9 9 convalescent convalescent JJ cord-328352-l1q4uvxl 9 10 plasma plasma NN cord-328352-l1q4uvxl 9 11 and and CC cord-328352-l1q4uvxl 9 12 stem stem NN cord-328352-l1q4uvxl 9 13 cells cell NNS cord-328352-l1q4uvxl 9 14 , , , cord-328352-l1q4uvxl 9 15 we -PRON- PRP cord-328352-l1q4uvxl 9 16 discuss discuss VBP cord-328352-l1q4uvxl 9 17 here here RB cord-328352-l1q4uvxl 9 18 their -PRON- PRP$ cord-328352-l1q4uvxl 9 19 potential potential JJ cord-328352-l1q4uvxl 9 20 use use NN cord-328352-l1q4uvxl 9 21 for for IN cord-328352-l1q4uvxl 9 22 treating treat VBG cord-328352-l1q4uvxl 9 23 COVID-19 covid-19 NN cord-328352-l1q4uvxl 9 24 . . . cord-328352-l1q4uvxl 10 1 may may MD cord-328352-l1q4uvxl 10 2 be be VB cord-328352-l1q4uvxl 10 3 likely likely RB cord-328352-l1q4uvxl 10 4 accounted account VBN cord-328352-l1q4uvxl 10 5 for for IN cord-328352-l1q4uvxl 10 6 by by IN cord-328352-l1q4uvxl 10 7 human human JJ cord-328352-l1q4uvxl 10 8 behavior behavior NN cord-328352-l1q4uvxl 10 9 , , , cord-328352-l1q4uvxl 10 10 especially especially RB cord-328352-l1q4uvxl 10 11 those those DT cord-328352-l1q4uvxl 10 12 who who WP cord-328352-l1q4uvxl 10 13 do do VBP cord-328352-l1q4uvxl 10 14 not not RB cord-328352-l1q4uvxl 10 15 take take VB cord-328352-l1q4uvxl 10 16 seriously seriously RB cord-328352-l1q4uvxl 10 17 the the DT cord-328352-l1q4uvxl 10 18 Centers Centers NNPS cord-328352-l1q4uvxl 10 19 for for IN cord-328352-l1q4uvxl 10 20 Disease Disease NNP cord-328352-l1q4uvxl 10 21 Control Control NNP cord-328352-l1q4uvxl 10 22 and and CC cord-328352-l1q4uvxl 10 23 Prevention Prevention NNP cord-328352-l1q4uvxl 10 24 ( ( -LRB- cord-328352-l1q4uvxl 10 25 CDC)-recommended cdc)-recommende VBN cord-328352-l1q4uvxl 10 26 public public JJ cord-328352-l1q4uvxl 10 27 health health NN cord-328352-l1q4uvxl 10 28 practices practice NNS cord-328352-l1q4uvxl 10 29 of of IN cord-328352-l1q4uvxl 10 30 social social JJ cord-328352-l1q4uvxl 10 31 distancing distancing NN cord-328352-l1q4uvxl 10 32 and and CC cord-328352-l1q4uvxl 10 33 proper proper JJ cord-328352-l1q4uvxl 10 34 hygiene hygiene NN cord-328352-l1q4uvxl 10 35 , , , cord-328352-l1q4uvxl 10 36 i.e. i.e. FW cord-328352-l1q4uvxl 10 37 , , , cord-328352-l1q4uvxl 10 38 washing washing NN cord-328352-l1q4uvxl 10 39 of of IN cord-328352-l1q4uvxl 10 40 hands hand NNS cord-328352-l1q4uvxl 10 41 with with IN cord-328352-l1q4uvxl 10 42 soap soap NN cord-328352-l1q4uvxl 10 43 and and CC cord-328352-l1q4uvxl 10 44 water water NN cord-328352-l1q4uvxl 10 45 . . . cord-328352-l1q4uvxl 11 1 Moreover moreover RB cord-328352-l1q4uvxl 11 2 , , , cord-328352-l1q4uvxl 11 3 the the DT cord-328352-l1q4uvxl 11 4 virusassociated virusassociated JJ cord-328352-l1q4uvxl 11 5 microdroplets microdroplet NNS cord-328352-l1q4uvxl 11 6 can can MD cord-328352-l1q4uvxl 11 7 stay stay VB cord-328352-l1q4uvxl 11 8 airborne airborne JJ cord-328352-l1q4uvxl 11 9 for for IN cord-328352-l1q4uvxl 11 10 up up IN cord-328352-l1q4uvxl 11 11 to to TO cord-328352-l1q4uvxl 11 12 3 3 CD cord-328352-l1q4uvxl 11 13 h h NN cord-328352-l1q4uvxl 11 14 6 6 CD cord-328352-l1q4uvxl 11 15 , , , cord-328352-l1q4uvxl 11 16 necessitating necessitate VBG cord-328352-l1q4uvxl 11 17 the the DT cord-328352-l1q4uvxl 11 18 need need NN cord-328352-l1q4uvxl 11 19 for for IN cord-328352-l1q4uvxl 11 20 wearing wear VBG cord-328352-l1q4uvxl 11 21 a a DT cord-328352-l1q4uvxl 11 22 face face NN cord-328352-l1q4uvxl 11 23 mask mask NN cord-328352-l1q4uvxl 11 24 to to TO cord-328352-l1q4uvxl 11 25 protect protect VB cord-328352-l1q4uvxl 11 26 ourselves -PRON- PRP cord-328352-l1q4uvxl 11 27 and and CC cord-328352-l1q4uvxl 11 28 others other NNS cord-328352-l1q4uvxl 11 29 . . . cord-328352-l1q4uvxl 12 1 The the DT cord-328352-l1q4uvxl 12 2 combination combination NN cord-328352-l1q4uvxl 12 3 of of IN cord-328352-l1q4uvxl 12 4 6-feet 6-feet CD cord-328352-l1q4uvxl 12 5 social social JJ cord-328352-l1q4uvxl 12 6 distancing distancing NN cord-328352-l1q4uvxl 12 7 , , , cord-328352-l1q4uvxl 12 8 20-s 20-s CD cord-328352-l1q4uvxl 12 9 hand hand NN cord-328352-l1q4uvxl 12 10 washing washing NN cord-328352-l1q4uvxl 12 11 , , , cord-328352-l1q4uvxl 12 12 and and CC cord-328352-l1q4uvxl 12 13 wearing wear VBG cord-328352-l1q4uvxl 12 14 N-95 N-95 NNP cord-328352-l1q4uvxl 12 15 or or CC cord-328352-l1q4uvxl 12 16 other other JJ cord-328352-l1q4uvxl 12 17 CDC CDC NNP cord-328352-l1q4uvxl 12 18 - - HYPH cord-328352-l1q4uvxl 12 19 recommended recommend VBN cord-328352-l1q4uvxl 12 20 face face NN cord-328352-l1q4uvxl 12 21 masks mask NNS cord-328352-l1q4uvxl 12 22 has have VBZ cord-328352-l1q4uvxl 12 23 been be VBN cord-328352-l1q4uvxl 12 24 reported report VBN cord-328352-l1q4uvxl 12 25 to to TO cord-328352-l1q4uvxl 12 26 curve curve VB cord-328352-l1q4uvxl 12 27 the the DT cord-328352-l1q4uvxl 12 28 spread spread NN cord-328352-l1q4uvxl 12 29 of of IN cord-328352-l1q4uvxl 12 30 virus virus NN cord-328352-l1q4uvxl 12 31 7 7 CD cord-328352-l1q4uvxl 12 32 , , , cord-328352-l1q4uvxl 12 33 8 8 CD cord-328352-l1q4uvxl 12 34 , , , cord-328352-l1q4uvxl 12 35 but but CC cord-328352-l1q4uvxl 12 36 quantifying quantify VBG cord-328352-l1q4uvxl 12 37 the the DT cord-328352-l1q4uvxl 12 38 risk risk NN cord-328352-l1q4uvxl 12 39 of of IN cord-328352-l1q4uvxl 12 40 reducing reduce VBG cord-328352-l1q4uvxl 12 41 these these DT cord-328352-l1q4uvxl 12 42 strategies strategy NNS cord-328352-l1q4uvxl 12 43 remains remain VBZ cord-328352-l1q4uvxl 12 44 debatable debatable JJ cord-328352-l1q4uvxl 12 45 . . . cord-328352-l1q4uvxl 13 1 Notwithstanding notwithstanding IN cord-328352-l1q4uvxl 13 2 , , , cord-328352-l1q4uvxl 13 3 the the DT cord-328352-l1q4uvxl 13 4 CDC CDC NNP cord-328352-l1q4uvxl 13 5 continues continue VBZ cord-328352-l1q4uvxl 13 6 to to TO cord-328352-l1q4uvxl 13 7 stress stress VB cord-328352-l1q4uvxl 13 8 practicing practice VBG cord-328352-l1q4uvxl 13 9 social social JJ cord-328352-l1q4uvxl 13 10 distancing distancing NN cord-328352-l1q4uvxl 13 11 , , , cord-328352-l1q4uvxl 13 12 hand hand NN cord-328352-l1q4uvxl 13 13 washing washing NN cord-328352-l1q4uvxl 13 14 , , , cord-328352-l1q4uvxl 13 15 and and CC cord-328352-l1q4uvxl 13 16 wearing wear VBG cord-328352-l1q4uvxl 13 17 a a DT cord-328352-l1q4uvxl 13 18 face face NN cord-328352-l1q4uvxl 13 19 mask mask NN cord-328352-l1q4uvxl 13 20 in in IN cord-328352-l1q4uvxl 13 21 order order NN cord-328352-l1q4uvxl 13 22 to to TO cord-328352-l1q4uvxl 13 23 inhibit inhibit VB cord-328352-l1q4uvxl 13 24 future future JJ cord-328352-l1q4uvxl 13 25 deaths death NNS cord-328352-l1q4uvxl 13 26 from from IN cord-328352-l1q4uvxl 13 27 the the DT cord-328352-l1q4uvxl 13 28 virus virus NN cord-328352-l1q4uvxl 13 29 . . . cord-328352-l1q4uvxl 14 1 Otherwise otherwise RB cord-328352-l1q4uvxl 14 2 , , , cord-328352-l1q4uvxl 14 3 we -PRON- PRP cord-328352-l1q4uvxl 14 4 are be VBP cord-328352-l1q4uvxl 14 5 living live VBG cord-328352-l1q4uvxl 14 6 in in IN cord-328352-l1q4uvxl 14 7 our -PRON- PRP$ cord-328352-l1q4uvxl 14 8 " " `` cord-328352-l1q4uvxl 14 9 disillusioned disillusioned JJ cord-328352-l1q4uvxl 14 10 comfort comfort NN cord-328352-l1q4uvxl 14 11 , , , cord-328352-l1q4uvxl 14 12 " " '' cord-328352-l1q4uvxl 14 13 similar similar JJ cord-328352-l1q4uvxl 14 14 to to IN cord-328352-l1q4uvxl 14 15 the the DT cord-328352-l1q4uvxl 14 16 misguided misguided JJ cord-328352-l1q4uvxl 14 17 security security NN cord-328352-l1q4uvxl 14 18 blanket blanket NN cord-328352-l1q4uvxl 14 19 we -PRON- PRP cord-328352-l1q4uvxl 14 20 afford afford VBP cord-328352-l1q4uvxl 14 21 to to IN cord-328352-l1q4uvxl 14 22 negative negative JJ cord-328352-l1q4uvxl 14 23 consequences consequence NNS cord-328352-l1q4uvxl 14 24 of of IN cord-328352-l1q4uvxl 14 25 smoking smoking NN cord-328352-l1q4uvxl 14 26 , , , cord-328352-l1q4uvxl 14 27 gambling gambling NN cord-328352-l1q4uvxl 14 28 , , , cord-328352-l1q4uvxl 14 29 and and CC cord-328352-l1q4uvxl 14 30 riding ride VBG cord-328352-l1q4uvxl 14 31 a a DT cord-328352-l1q4uvxl 14 32 motorcycle motorcycle NN cord-328352-l1q4uvxl 14 33 . . . cord-328352-l1q4uvxl 15 1 A a DT cord-328352-l1q4uvxl 15 2 historical historical JJ cord-328352-l1q4uvxl 15 3 review review NN cord-328352-l1q4uvxl 15 4 of of IN cord-328352-l1q4uvxl 15 5 virus virus NN cord-328352-l1q4uvxl 15 6 - - HYPH cord-328352-l1q4uvxl 15 7 related relate VBN cord-328352-l1q4uvxl 15 8 pandemics pandemic NNS cord-328352-l1q4uvxl 15 9 reminds remind VBZ cord-328352-l1q4uvxl 15 10 us -PRON- PRP cord-328352-l1q4uvxl 15 11 of of IN cord-328352-l1q4uvxl 15 12 the the DT cord-328352-l1q4uvxl 15 13 1918 1918 CD cord-328352-l1q4uvxl 15 14 Spanish spanish JJ cord-328352-l1q4uvxl 15 15 flu flu NN cord-328352-l1q4uvxl 15 16 , , , cord-328352-l1q4uvxl 15 17 which which WDT cord-328352-l1q4uvxl 15 18 infected infect VBD cord-328352-l1q4uvxl 15 19 500 500 CD cord-328352-l1q4uvxl 15 20 million million CD cord-328352-l1q4uvxl 15 21 and and CC cord-328352-l1q4uvxl 15 22 estimated estimate VBN cord-328352-l1q4uvxl 15 23 to to TO cord-328352-l1q4uvxl 15 24 have have VB cord-328352-l1q4uvxl 15 25 killed kill VBN cord-328352-l1q4uvxl 15 26 about about RB cord-328352-l1q4uvxl 15 27 17 17 CD cord-328352-l1q4uvxl 15 28 million million CD cord-328352-l1q4uvxl 15 29 to to TO cord-328352-l1q4uvxl 15 30 50 50 CD cord-328352-l1q4uvxl 15 31 million million CD cord-328352-l1q4uvxl 15 32 people people NNS cord-328352-l1q4uvxl 15 33 9 9 CD cord-328352-l1q4uvxl 15 34 . . . cord-328352-l1q4uvxl 16 1 The the DT cord-328352-l1q4uvxl 16 2 Spanish spanish JJ cord-328352-l1q4uvxl 16 3 flu flu NN cord-328352-l1q4uvxl 16 4 resembles resemble VBZ cord-328352-l1q4uvxl 16 5 COVID-19 covid-19 VB cord-328352-l1q4uvxl 16 6 : : : cord-328352-l1q4uvxl 16 7 both both DT cord-328352-l1q4uvxl 16 8 are be VBP cord-328352-l1q4uvxl 16 9 respiratory respiratory JJ cord-328352-l1q4uvxl 16 10 viruses virus NNS cord-328352-l1q4uvxl 16 11 with with IN cord-328352-l1q4uvxl 16 12 the the DT cord-328352-l1q4uvxl 16 13 precursor precursor NN cord-328352-l1q4uvxl 16 14 viruses virus NNS cord-328352-l1q4uvxl 16 15 mutating mutate VBG cord-328352-l1q4uvxl 16 16 in in IN cord-328352-l1q4uvxl 16 17 animals animal NNS cord-328352-l1q4uvxl 16 18 thereafter thereafter RB cord-328352-l1q4uvxl 16 19 infecting infect VBG cord-328352-l1q4uvxl 16 20 humans human NNS cord-328352-l1q4uvxl 16 21 , , , cord-328352-l1q4uvxl 16 22 and and CC cord-328352-l1q4uvxl 16 23 with with IN cord-328352-l1q4uvxl 16 24 fast fast JJ cord-328352-l1q4uvxl 16 25 - - HYPH cord-328352-l1q4uvxl 16 26 progressive progressive JJ cord-328352-l1q4uvxl 16 27 cases case NNS cord-328352-l1q4uvxl 16 28 from from IN cord-328352-l1q4uvxl 16 29 infection infection NN cord-328352-l1q4uvxl 16 30 to to IN cord-328352-l1q4uvxl 16 31 symptom symptom NN cord-328352-l1q4uvxl 16 32 onset onset NN cord-328352-l1q4uvxl 16 33 with with IN cord-328352-l1q4uvxl 16 34 viral viral JJ cord-328352-l1q4uvxl 16 35 consolidation consolidation NN cord-328352-l1q4uvxl 16 36 in in IN cord-328352-l1q4uvxl 16 37 the the DT cord-328352-l1q4uvxl 16 38 lung lung NN cord-328352-l1q4uvxl 16 39 and and CC cord-328352-l1q4uvxl 16 40 eventually eventually RB cord-328352-l1q4uvxl 16 41 mortality mortality NN cord-328352-l1q4uvxl 16 42 primarily primarily RB cord-328352-l1q4uvxl 16 43 from from IN cord-328352-l1q4uvxl 16 44 pneumonia pneumonia NN cord-328352-l1q4uvxl 16 45 9 9 CD cord-328352-l1q4uvxl 16 46 - - SYM cord-328352-l1q4uvxl 16 47 12 12 CD cord-328352-l1q4uvxl 16 48 . . . cord-328352-l1q4uvxl 17 1 Eerily eerily RB cord-328352-l1q4uvxl 17 2 enough enough RB cord-328352-l1q4uvxl 17 3 , , , cord-328352-l1q4uvxl 17 4 the the DT cord-328352-l1q4uvxl 17 5 key key JJ cord-328352-l1q4uvxl 17 6 promoters promoter NNS cord-328352-l1q4uvxl 17 7 of of IN cord-328352-l1q4uvxl 17 8 such such JJ cord-328352-l1q4uvxl 17 9 high high JJ cord-328352-l1q4uvxl 17 10 mortality mortality NN cord-328352-l1q4uvxl 17 11 rate rate NN cord-328352-l1q4uvxl 17 12 of of IN cord-328352-l1q4uvxl 17 13 Spanish spanish JJ cord-328352-l1q4uvxl 17 14 flu flu NN cord-328352-l1q4uvxl 17 15 were be VBD cord-328352-l1q4uvxl 17 16 overcrowding overcrowd VBG cord-328352-l1q4uvxl 17 17 and and CC cord-328352-l1q4uvxl 17 18 poor poor JJ cord-328352-l1q4uvxl 17 19 hygiene hygiene NN cord-328352-l1q4uvxl 17 20 - - , cord-328352-l1q4uvxl 17 21 the the DT cord-328352-l1q4uvxl 17 22 same same JJ cord-328352-l1q4uvxl 17 23 two two CD cord-328352-l1q4uvxl 17 24 factors factor NNS cord-328352-l1q4uvxl 17 25 that that WDT cord-328352-l1q4uvxl 17 26 define define VBP cord-328352-l1q4uvxl 17 27 our -PRON- PRP$ cord-328352-l1q4uvxl 17 28 disillusioned disillusioned JJ cord-328352-l1q4uvxl 17 29 comfort comfort NN cord-328352-l1q4uvxl 17 30 for for IN cord-328352-l1q4uvxl 17 31 COVID-19 COVID-19 NNP cord-328352-l1q4uvxl 17 32 . . . cord-328352-l1q4uvxl 18 1 Human human JJ cord-328352-l1q4uvxl 18 2 behavior behavior NN cord-328352-l1q4uvxl 18 3 to to IN cord-328352-l1q4uvxl 18 4 the the DT cord-328352-l1q4uvxl 18 5 Spanish spanish JJ cord-328352-l1q4uvxl 18 6 flu flu NN cord-328352-l1q4uvxl 18 7 outbreak outbreak NN cord-328352-l1q4uvxl 18 8 stands stand VBZ cord-328352-l1q4uvxl 18 9 as as IN cord-328352-l1q4uvxl 18 10 the the DT cord-328352-l1q4uvxl 18 11 major major JJ cord-328352-l1q4uvxl 18 12 determinant determinant NN cord-328352-l1q4uvxl 18 13 for for IN cord-328352-l1q4uvxl 18 14 the the DT cord-328352-l1q4uvxl 18 15 pattern pattern NN cord-328352-l1q4uvxl 18 16 of of IN cord-328352-l1q4uvxl 18 17 the the DT cord-328352-l1q4uvxl 18 18 pandemic pandemic NN cord-328352-l1q4uvxl 18 19 's 's POS cord-328352-l1q4uvxl 18 20 high high JJ cord-328352-l1q4uvxl 18 21 mortality mortality NN cord-328352-l1q4uvxl 18 22 rate rate NN cord-328352-l1q4uvxl 18 23 13 13 CD cord-328352-l1q4uvxl 18 24 . . . cord-328352-l1q4uvxl 19 1 Again again RB cord-328352-l1q4uvxl 19 2 , , , cord-328352-l1q4uvxl 19 3 the the DT cord-328352-l1q4uvxl 19 4 same same JJ cord-328352-l1q4uvxl 19 5 human human JJ cord-328352-l1q4uvxl 19 6 response response NN cord-328352-l1q4uvxl 19 7 , , , cord-328352-l1q4uvxl 19 8 or or CC cord-328352-l1q4uvxl 19 9 lack lack NN cord-328352-l1q4uvxl 19 10 thereof thereof RB cord-328352-l1q4uvxl 19 11 , , , cord-328352-l1q4uvxl 19 12 that that WDT cord-328352-l1q4uvxl 19 13 faces face VBZ cord-328352-l1q4uvxl 19 14 COVID-19 covid-19 VB cord-328352-l1q4uvxl 19 15 . . . cord-328352-l1q4uvxl 20 1 A a DT cord-328352-l1q4uvxl 20 2 Spanish spanish JJ cord-328352-l1q4uvxl 20 3 flu flu NN cord-328352-l1q4uvxl 20 4 vaccine vaccine NN cord-328352-l1q4uvxl 20 5 was be VBD cord-328352-l1q4uvxl 20 6 not not RB cord-328352-l1q4uvxl 20 7 available available JJ cord-328352-l1q4uvxl 20 8 during during IN cord-328352-l1q4uvxl 20 9 the the DT cord-328352-l1q4uvxl 20 10 1918 1918 CD cord-328352-l1q4uvxl 20 11 pandemic pandemic NN cord-328352-l1q4uvxl 20 12 , , , cord-328352-l1q4uvxl 20 13 with with IN cord-328352-l1q4uvxl 20 14 the the DT cord-328352-l1q4uvxl 20 15 virus virus NN cord-328352-l1q4uvxl 20 16 remaining remain VBG cord-328352-l1q4uvxl 20 17 largely largely RB cord-328352-l1q4uvxl 20 18 unknown unknown JJ cord-328352-l1q4uvxl 20 19 for for IN cord-328352-l1q4uvxl 20 20 almost almost RB cord-328352-l1q4uvxl 20 21 a a DT cord-328352-l1q4uvxl 20 22 century century NN cord-328352-l1q4uvxl 20 23 when when WRB cord-328352-l1q4uvxl 20 24 the the DT cord-328352-l1q4uvxl 20 25 molecular molecular JJ cord-328352-l1q4uvxl 20 26 underpinnings underpinning NNS cord-328352-l1q4uvxl 20 27 of of IN cord-328352-l1q4uvxl 20 28 the the DT cord-328352-l1q4uvxl 20 29 virus virus NN cord-328352-l1q4uvxl 20 30 were be VBD cord-328352-l1q4uvxl 20 31 finally finally RB cord-328352-l1q4uvxl 20 32 characterized characterize VBN cord-328352-l1q4uvxl 20 33 in in IN cord-328352-l1q4uvxl 20 34 2005 2005 CD cord-328352-l1q4uvxl 20 35 14 14 CD cord-328352-l1q4uvxl 20 36 . . . cord-328352-l1q4uvxl 21 1 Similar similar JJ cord-328352-l1q4uvxl 21 2 to to IN cord-328352-l1q4uvxl 21 3 COVID-19 covid-19 VB cord-328352-l1q4uvxl 21 4 , , , cord-328352-l1q4uvxl 21 5 the the DT cord-328352-l1q4uvxl 21 6 1918 1918 CD cord-328352-l1q4uvxl 21 7 Spanish spanish JJ cord-328352-l1q4uvxl 21 8 flu flu NN cord-328352-l1q4uvxl 21 9 was be VBD cord-328352-l1q4uvxl 21 10 first first RB cord-328352-l1q4uvxl 21 11 detected detect VBN cord-328352-l1q4uvxl 21 12 in in IN cord-328352-l1q4uvxl 21 13 the the DT cord-328352-l1q4uvxl 21 14 month month NN cord-328352-l1q4uvxl 21 15 of of IN cord-328352-l1q4uvxl 21 16 January January NNP cord-328352-l1q4uvxl 21 17 , , , cord-328352-l1q4uvxl 21 18 but but CC cord-328352-l1q4uvxl 21 19 after after IN cord-328352-l1q4uvxl 21 20 the the DT cord-328352-l1q4uvxl 21 21 second second JJ cord-328352-l1q4uvxl 21 22 wave wave NN cord-328352-l1q4uvxl 21 23 in in IN cord-328352-l1q4uvxl 21 24 August August NNP cord-328352-l1q4uvxl 21 25 of of IN cord-328352-l1q4uvxl 21 26 that that DT cord-328352-l1q4uvxl 21 27 year year NN cord-328352-l1q4uvxl 21 28 , , , cord-328352-l1q4uvxl 21 29 the the DT cord-328352-l1q4uvxl 21 30 number number NN cord-328352-l1q4uvxl 21 31 of of IN cord-328352-l1q4uvxl 21 32 cases case NNS cord-328352-l1q4uvxl 21 33 dropped drop VBD cord-328352-l1q4uvxl 21 34 significantly significantly RB cord-328352-l1q4uvxl 21 35 and and CC cord-328352-l1q4uvxl 21 36 almost almost RB cord-328352-l1q4uvxl 21 37 disappeared disappear VBD cord-328352-l1q4uvxl 21 38 by by IN cord-328352-l1q4uvxl 21 39 the the DT cord-328352-l1q4uvxl 21 40 year year NN cord-328352-l1q4uvxl 21 41 's 's POS cord-328352-l1q4uvxl 21 42 end end NN cord-328352-l1q4uvxl 21 43 . . . cord-328352-l1q4uvxl 22 1 Without without IN cord-328352-l1q4uvxl 22 2 a a DT cord-328352-l1q4uvxl 22 3 vaccine vaccine NN cord-328352-l1q4uvxl 22 4 , , , cord-328352-l1q4uvxl 22 5 the the DT cord-328352-l1q4uvxl 22 6 rapid rapid JJ cord-328352-l1q4uvxl 22 7 decline decline NN cord-328352-l1q4uvxl 22 8 in in IN cord-328352-l1q4uvxl 22 9 infection infection NN cord-328352-l1q4uvxl 22 10 and and CC cord-328352-l1q4uvxl 22 11 mortality mortality NN cord-328352-l1q4uvxl 22 12 after after IN cord-328352-l1q4uvxl 22 13 the the DT cord-328352-l1q4uvxl 22 14 second second NN cord-328352-l1q4uvxl 22 15 of of IN cord-328352-l1q4uvxl 22 16 the the DT cord-328352-l1q4uvxl 22 17 two two CD cord-328352-l1q4uvxl 22 18 lethal lethal JJ cord-328352-l1q4uvxl 22 19 waves wave NNS cord-328352-l1q4uvxl 22 20 of of IN cord-328352-l1q4uvxl 22 21 Spanish spanish JJ cord-328352-l1q4uvxl 22 22 flu flu NN cord-328352-l1q4uvxl 22 23 was be VBD cord-328352-l1q4uvxl 22 24 attributed attribute VBN cord-328352-l1q4uvxl 22 25 to to IN cord-328352-l1q4uvxl 22 26 better well JJR cord-328352-l1q4uvxl 22 27 treatment treatment NN cord-328352-l1q4uvxl 22 28 of of IN cord-328352-l1q4uvxl 22 29 pneumonia pneumonia NN cord-328352-l1q4uvxl 22 30 and and CC cord-328352-l1q4uvxl 22 31 the the DT cord-328352-l1q4uvxl 22 32 virus virus NN cord-328352-l1q4uvxl 22 33 mutating mutate VBG cord-328352-l1q4uvxl 22 34 to to IN cord-328352-l1q4uvxl 22 35 a a DT cord-328352-l1q4uvxl 22 36 less less RBR cord-328352-l1q4uvxl 22 37 dangerous dangerous JJ cord-328352-l1q4uvxl 22 38 strain strain NN cord-328352-l1q4uvxl 22 39 . . . cord-328352-l1q4uvxl 23 1 Three three CD cord-328352-l1q4uvxl 23 2 key key JJ cord-328352-l1q4uvxl 23 3 lessons lesson NNS cord-328352-l1q4uvxl 23 4 from from IN cord-328352-l1q4uvxl 23 5 the the DT cord-328352-l1q4uvxl 23 6 Spanish spanish JJ cord-328352-l1q4uvxl 23 7 flu flu NN cord-328352-l1q4uvxl 23 8 pandemic pandemic NN cord-328352-l1q4uvxl 23 9 are be VBP cord-328352-l1q4uvxl 23 10 worthy worthy JJ cord-328352-l1q4uvxl 23 11 of of IN cord-328352-l1q4uvxl 23 12 consideration consideration NN cord-328352-l1q4uvxl 23 13 . . . cord-328352-l1q4uvxl 24 1 First first RB cord-328352-l1q4uvxl 24 2 , , , cord-328352-l1q4uvxl 24 3 those those DT cord-328352-l1q4uvxl 24 4 who who WP cord-328352-l1q4uvxl 24 5 survived survive VBD cord-328352-l1q4uvxl 24 6 the the DT cord-328352-l1q4uvxl 24 7 first first JJ cord-328352-l1q4uvxl 24 8 wave wave NN cord-328352-l1q4uvxl 24 9 developed develop VBN cord-328352-l1q4uvxl 24 10 immunity immunity NN cord-328352-l1q4uvxl 24 11 against against IN cord-328352-l1q4uvxl 24 12 the the DT cord-328352-l1q4uvxl 24 13 virus virus NN cord-328352-l1q4uvxl 24 14 ; ; : cord-328352-l1q4uvxl 24 15 thus thus RB cord-328352-l1q4uvxl 24 16 , , , cord-328352-l1q4uvxl 24 17 these these DT cord-328352-l1q4uvxl 24 18 individuals individual NNS cord-328352-l1q4uvxl 24 19 were be VBD cord-328352-l1q4uvxl 24 20 immune immune JJ cord-328352-l1q4uvxl 24 21 to to IN cord-328352-l1q4uvxl 24 22 the the DT cord-328352-l1q4uvxl 24 23 second second JJ cord-328352-l1q4uvxl 24 24 wave wave NN cord-328352-l1q4uvxl 24 25 of of IN cord-328352-l1q4uvxl 24 26 the the DT cord-328352-l1q4uvxl 24 27 Spanish spanish JJ cord-328352-l1q4uvxl 24 28 flu flu NN cord-328352-l1q4uvxl 24 29 , , , cord-328352-l1q4uvxl 24 30 providing provide VBG cord-328352-l1q4uvxl 24 31 us -PRON- PRP cord-328352-l1q4uvxl 24 32 a a DT cord-328352-l1q4uvxl 24 33 glimpse glimpse NN cord-328352-l1q4uvxl 24 34 on on IN cord-328352-l1q4uvxl 24 35 the the DT cord-328352-l1q4uvxl 24 36 future future NN cord-328352-l1q4uvxl 24 37 of of IN cord-328352-l1q4uvxl 24 38 passive passive JJ cord-328352-l1q4uvxl 24 39 immunitybased immunitybase VBN cord-328352-l1q4uvxl 24 40 treatment treatment NN cord-328352-l1q4uvxl 24 41 against against IN cord-328352-l1q4uvxl 24 42 the the DT cord-328352-l1q4uvxl 24 43 virus virus NN cord-328352-l1q4uvxl 24 44 . . . cord-328352-l1q4uvxl 25 1 Indeed indeed RB cord-328352-l1q4uvxl 25 2 , , , cord-328352-l1q4uvxl 25 3 clinical clinical JJ cord-328352-l1q4uvxl 25 4 trials trial NNS cord-328352-l1q4uvxl 25 5 have have VBP cord-328352-l1q4uvxl 25 6 recently recently RB cord-328352-l1q4uvxl 25 7 been be VBN cord-328352-l1q4uvxl 25 8 initiated initiate VBN cord-328352-l1q4uvxl 25 9 using use VBG cord-328352-l1q4uvxl 25 10 plasma plasma NN cord-328352-l1q4uvxl 25 11 collected collect VBN cord-328352-l1q4uvxl 25 12 from from IN cord-328352-l1q4uvxl 25 13 recovered recover VBN cord-328352-l1q4uvxl 25 14 COVID-19 COVID-19 NNP cord-328352-l1q4uvxl 25 15 patients patient NNS cord-328352-l1q4uvxl 25 16 based base VBN cord-328352-l1q4uvxl 25 17 on on IN cord-328352-l1q4uvxl 25 18 the the DT cord-328352-l1q4uvxl 25 19 concept concept NN cord-328352-l1q4uvxl 25 20 that that IN cord-328352-l1q4uvxl 25 21 these these DT cord-328352-l1q4uvxl 25 22 individuals individual NNS cord-328352-l1q4uvxl 25 23 have have VBP cord-328352-l1q4uvxl 25 24 likely likely RB cord-328352-l1q4uvxl 25 25 harbored harbor VBN cord-328352-l1q4uvxl 25 26 strong strong JJ cord-328352-l1q4uvxl 25 27 immune immune JJ cord-328352-l1q4uvxl 25 28 responses response NNS cord-328352-l1q4uvxl 25 29 such such JJ cord-328352-l1q4uvxl 25 30 as as IN cord-328352-l1q4uvxl 25 31 antibodies antibody NNS cord-328352-l1q4uvxl 25 32 that that WDT cord-328352-l1q4uvxl 25 33 target target VBP cord-328352-l1q4uvxl 25 34 the the DT cord-328352-l1q4uvxl 25 35 proteins protein NNS cord-328352-l1q4uvxl 25 36 found find VBN cord-328352-l1q4uvxl 25 37 on on IN cord-328352-l1q4uvxl 25 38 COVID-19 COVID-19 NNP cord-328352-l1q4uvxl 25 39 15 15 CD cord-328352-l1q4uvxl 25 40 . . . cord-328352-l1q4uvxl 26 1 Second second RB cord-328352-l1q4uvxl 26 2 , , , cord-328352-l1q4uvxl 26 3 that that IN cord-328352-l1q4uvxl 26 4 the the DT cord-328352-l1q4uvxl 26 5 end end NN cord-328352-l1q4uvxl 26 6 of of IN cord-328352-l1q4uvxl 26 7 Spanish spanish JJ cord-328352-l1q4uvxl 26 8 flu flu NN cord-328352-l1q4uvxl 26 9 cases case NNS cord-328352-l1q4uvxl 26 10 by by IN cord-328352-l1q4uvxl 26 11 1920 1920 CD cord-328352-l1q4uvxl 26 12 might may MD cord-328352-l1q4uvxl 26 13 have have VB cord-328352-l1q4uvxl 26 14 signaled signal VBN cord-328352-l1q4uvxl 26 15 the the DT cord-328352-l1q4uvxl 26 16 eradication eradication NN cord-328352-l1q4uvxl 26 17 of of IN cord-328352-l1q4uvxl 26 18 the the DT cord-328352-l1q4uvxl 26 19 pandemic pandemic NN cord-328352-l1q4uvxl 26 20 may may MD cord-328352-l1q4uvxl 26 21 not not RB cord-328352-l1q4uvxl 26 22 be be VB cord-328352-l1q4uvxl 26 23 completely completely RB cord-328352-l1q4uvxl 26 24 true true JJ cord-328352-l1q4uvxl 26 25 . . . cord-328352-l1q4uvxl 27 1 Evidence evidence NN cord-328352-l1q4uvxl 27 2 of of IN cord-328352-l1q4uvxl 27 3 slow slow JJ cord-328352-l1q4uvxl 27 4 - - HYPH cord-328352-l1q4uvxl 27 5 progressive progressive JJ cord-328352-l1q4uvxl 27 6 cases case NNS cord-328352-l1q4uvxl 27 7 of of IN cord-328352-l1q4uvxl 27 8 Spanish spanish JJ cord-328352-l1q4uvxl 27 9 flu flu NN cord-328352-l1q4uvxl 27 10 has have VBZ cord-328352-l1q4uvxl 27 11 been be VBN cord-328352-l1q4uvxl 27 12 linked link VBN cord-328352-l1q4uvxl 27 13 to to IN cord-328352-l1q4uvxl 27 14 secondary secondary JJ cord-328352-l1q4uvxl 27 15 bacterial bacterial JJ cord-328352-l1q4uvxl 27 16 pneumonia pneumonia NN cord-328352-l1q4uvxl 27 17 , , , cord-328352-l1q4uvxl 27 18 possibly possibly RB cord-328352-l1q4uvxl 27 19 affecting affect VBG cord-328352-l1q4uvxl 27 20 the the DT cord-328352-l1q4uvxl 27 21 brain brain NN cord-328352-l1q4uvxl 27 22 , , , cord-328352-l1q4uvxl 27 23 which which WDT cord-328352-l1q4uvxl 27 24 results result VBZ cord-328352-l1q4uvxl 27 25 in in IN cord-328352-l1q4uvxl 27 26 neurological neurological JJ cord-328352-l1q4uvxl 27 27 disorders disorder NNS cord-328352-l1q4uvxl 27 28 , , , cord-328352-l1q4uvxl 27 29 in in IN cord-328352-l1q4uvxl 27 30 particular particular JJ cord-328352-l1q4uvxl 27 31 encephalitis encephalitis RB cord-328352-l1q4uvxl 27 32 lethargica lethargica NNP cord-328352-l1q4uvxl 27 33 , , , cord-328352-l1q4uvxl 27 34 that that WDT cord-328352-l1q4uvxl 27 35 recorded record VBD cord-328352-l1q4uvxl 27 36 its -PRON- PRP$ cord-328352-l1q4uvxl 27 37 outbreak outbreak NN cord-328352-l1q4uvxl 27 38 in in IN cord-328352-l1q4uvxl 27 39 the the DT cord-328352-l1q4uvxl 27 40 1920s 1920 NNS cord-328352-l1q4uvxl 27 41 , , , cord-328352-l1q4uvxl 27 42 in in IN cord-328352-l1q4uvxl 27 43 children child NNS cord-328352-l1q4uvxl 27 44 16 16 CD cord-328352-l1q4uvxl 27 45 , , , cord-328352-l1q4uvxl 27 46 which which WDT cord-328352-l1q4uvxl 27 47 was be VBD cord-328352-l1q4uvxl 27 48 suggested suggest VBN cord-328352-l1q4uvxl 27 49 to to TO cord-328352-l1q4uvxl 27 50 manifest manifest VB cord-328352-l1q4uvxl 27 51 in in IN cord-328352-l1q4uvxl 27 52 adulthood adulthood NN cord-328352-l1q4uvxl 27 53 as as IN cord-328352-l1q4uvxl 27 54 Parkinson Parkinson NNP cord-328352-l1q4uvxl 27 55 's 's POS cord-328352-l1q4uvxl 27 56 disease disease NN cord-328352-l1q4uvxl 27 57 17 17 CD cord-328352-l1q4uvxl 27 58 but but CC cord-328352-l1q4uvxl 27 59 such such PDT cord-328352-l1q4uvxl 27 60 a a DT cord-328352-l1q4uvxl 27 61 pathological pathological JJ cord-328352-l1q4uvxl 27 62 link link NN cord-328352-l1q4uvxl 27 63 being be VBG cord-328352-l1q4uvxl 27 64 merely merely RB cord-328352-l1q4uvxl 27 65 coincidental coincidental JJ cord-328352-l1q4uvxl 27 66 has have VBZ cord-328352-l1q4uvxl 27 67 been be VBN cord-328352-l1q4uvxl 27 68 debated debate VBN cord-328352-l1q4uvxl 27 69 18 18 CD cord-328352-l1q4uvxl 27 70 . . . cord-328352-l1q4uvxl 28 1 Similarly similarly RB cord-328352-l1q4uvxl 28 2 , , , cord-328352-l1q4uvxl 28 3 the the DT cord-328352-l1q4uvxl 28 4 potential potential JJ cord-328352-l1q4uvxl 28 5 long long JJ cord-328352-l1q4uvxl 28 6 - - HYPH cord-328352-l1q4uvxl 28 7 term term NN cord-328352-l1q4uvxl 28 8 consequences consequence NNS cord-328352-l1q4uvxl 28 9 of of IN cord-328352-l1q4uvxl 28 10 COVID-19 covid-19 NN cord-328352-l1q4uvxl 28 11 to to IN cord-328352-l1q4uvxl 28 12 brain brain NN cord-328352-l1q4uvxl 28 13 disorders disorder NNS cord-328352-l1q4uvxl 28 14 , , , cord-328352-l1q4uvxl 28 15 and and CC cord-328352-l1q4uvxl 28 16 other other JJ cord-328352-l1q4uvxl 28 17 comorbid comorbid NN cord-328352-l1q4uvxl 28 18 diseases disease NNS cord-328352-l1q4uvxl 28 19 , , , cord-328352-l1q4uvxl 28 20 warrant warrant VB cord-328352-l1q4uvxl 28 21 critical critical JJ cord-328352-l1q4uvxl 28 22 research research NN cord-328352-l1q4uvxl 28 23 avenues avenue NNS cord-328352-l1q4uvxl 28 24 as as IN cord-328352-l1q4uvxl 28 25 we -PRON- PRP cord-328352-l1q4uvxl 28 26 tackle tackle VBP cord-328352-l1q4uvxl 28 27 this this DT cord-328352-l1q4uvxl 28 28 pandemic pandemic NN cord-328352-l1q4uvxl 28 29 and and CC cord-328352-l1q4uvxl 28 30 its -PRON- PRP$ cord-328352-l1q4uvxl 28 31 associated associate VBN cord-328352-l1q4uvxl 28 32 not not RB cord-328352-l1q4uvxl 28 33 - - HYPH cord-328352-l1q4uvxl 28 34 so so RB cord-328352-l1q4uvxl 28 35 - - HYPH cord-328352-l1q4uvxl 28 36 apparent apparent JJ cord-328352-l1q4uvxl 28 37 mini mini JJ cord-328352-l1q4uvxl 28 38 outbreaks outbreak NNS cord-328352-l1q4uvxl 28 39 . . . cord-328352-l1q4uvxl 29 1 Third third RB cord-328352-l1q4uvxl 29 2 , , , cord-328352-l1q4uvxl 29 3 that that IN cord-328352-l1q4uvxl 29 4 overcrowding overcrowding NN cord-328352-l1q4uvxl 29 5 in in IN cord-328352-l1q4uvxl 29 6 military military JJ cord-328352-l1q4uvxl 29 7 camps camp NNS cord-328352-l1q4uvxl 29 8 and and CC cord-328352-l1q4uvxl 29 9 lack lack NN cord-328352-l1q4uvxl 29 10 of of IN cord-328352-l1q4uvxl 29 11 sanitation sanitation NN cord-328352-l1q4uvxl 29 12 due due IN cord-328352-l1q4uvxl 29 13 to to IN cord-328352-l1q4uvxl 29 14 poverty poverty NN cord-328352-l1q4uvxl 29 15 during during IN cord-328352-l1q4uvxl 29 16 World World NNP cord-328352-l1q4uvxl 29 17 War War NNP cord-328352-l1q4uvxl 30 1 I -PRON- PRP cord-328352-l1q4uvxl 30 2 contributed contribute VBD cord-328352-l1q4uvxl 30 3 to to IN cord-328352-l1q4uvxl 30 4 Spanish spanish JJ cord-328352-l1q4uvxl 30 5 flu flu NN cord-328352-l1q4uvxl 30 6 pandemic pandemic NN cord-328352-l1q4uvxl 31 1 draws draw VBZ cord-328352-l1q4uvxl 31 2 our -PRON- PRP$ cord-328352-l1q4uvxl 31 3 attention attention NN cord-328352-l1q4uvxl 31 4 to to IN cord-328352-l1q4uvxl 31 5 the the DT cord-328352-l1q4uvxl 31 6 key key JJ cord-328352-l1q4uvxl 31 7 pressing press VBG cord-328352-l1q4uvxl 31 8 issue issue NN cord-328352-l1q4uvxl 31 9 of of IN cord-328352-l1q4uvxl 31 10 human human JJ cord-328352-l1q4uvxl 31 11 behavior behavior NN cord-328352-l1q4uvxl 31 12 . . . cord-328352-l1q4uvxl 32 1 Regenerative regenerative JJ cord-328352-l1q4uvxl 32 2 medicine medicine NN cord-328352-l1q4uvxl 32 3 may may MD cord-328352-l1q4uvxl 32 4 play play VB cord-328352-l1q4uvxl 32 5 a a DT cord-328352-l1q4uvxl 32 6 key key JJ cord-328352-l1q4uvxl 32 7 role role NN cord-328352-l1q4uvxl 32 8 in in IN cord-328352-l1q4uvxl 32 9 treating treat VBG cord-328352-l1q4uvxl 32 10 COVID-19 covid-19 NN cord-328352-l1q4uvxl 32 11 . . . cord-328352-l1q4uvxl 33 1 The the DT cord-328352-l1q4uvxl 33 2 ongoing ongoing JJ cord-328352-l1q4uvxl 33 3 clinical clinical JJ cord-328352-l1q4uvxl 33 4 trials trial NNS cord-328352-l1q4uvxl 33 5 of of IN cord-328352-l1q4uvxl 33 6 infusing infuse VBG cord-328352-l1q4uvxl 33 7 convalescent convalescent JJ cord-328352-l1q4uvxl 33 8 plasma plasma NN cord-328352-l1q4uvxl 33 9 stand stand NN cord-328352-l1q4uvxl 33 10 as as IN cord-328352-l1q4uvxl 33 11 a a DT cord-328352-l1q4uvxl 33 12 potent potent JJ cord-328352-l1q4uvxl 33 13 cell cell NN cord-328352-l1q4uvxl 33 14 therapy therapy NN cord-328352-l1q4uvxl 33 15 for for IN cord-328352-l1q4uvxl 33 16 COVID-19 COVID-19 NNP cord-328352-l1q4uvxl 33 17 patients patient NNS cord-328352-l1q4uvxl 33 18 . . . cord-328352-l1q4uvxl 34 1 This this DT cord-328352-l1q4uvxl 34 2 investigational investigational JJ cord-328352-l1q4uvxl 34 3 treatment treatment NN cord-328352-l1q4uvxl 34 4 uses use VBZ cord-328352-l1q4uvxl 34 5 plasma plasma NN cord-328352-l1q4uvxl 34 6 that that WDT cord-328352-l1q4uvxl 34 7 contains contain VBZ cord-328352-l1q4uvxl 34 8 antibodies antibody NNS cord-328352-l1q4uvxl 34 9 to to TO cord-328352-l1q4uvxl 34 10 severe severe JJ cord-328352-l1q4uvxl 34 11 acute acute JJ cord-328352-l1q4uvxl 34 12 respiratory respiratory JJ cord-328352-l1q4uvxl 34 13 syndrome syndrome NN cord-328352-l1q4uvxl 34 14 coronavirus coronavirus NN cord-328352-l1q4uvxl 34 15 2 2 CD cord-328352-l1q4uvxl 34 16 or or CC cord-328352-l1q4uvxl 34 17 SARS SARS NNP cord-328352-l1q4uvxl 34 18 - - HYPH cord-328352-l1q4uvxl 34 19 CoV-2 CoV-2 NNP cord-328352-l1q4uvxl 34 20 , , , cord-328352-l1q4uvxl 34 21 the the DT cord-328352-l1q4uvxl 34 22 virus virus NN cord-328352-l1q4uvxl 34 23 that that WDT cord-328352-l1q4uvxl 34 24 causes cause VBZ cord-328352-l1q4uvxl 34 25 COVID-19 COVID-19 NNP cord-328352-l1q4uvxl 34 26 . . . cord-328352-l1q4uvxl 35 1 Plasma plasma NN cord-328352-l1q4uvxl 35 2 therapy therapy NN cord-328352-l1q4uvxl 35 3 entails entail VBZ cord-328352-l1q4uvxl 35 4 the the DT cord-328352-l1q4uvxl 35 5 use use NN cord-328352-l1q4uvxl 35 6 of of IN cord-328352-l1q4uvxl 35 7 plasma plasma NN cord-328352-l1q4uvxl 35 8 or or CC cord-328352-l1q4uvxl 35 9 specific specific JJ cord-328352-l1q4uvxl 35 10 , , , cord-328352-l1q4uvxl 35 11 fractioned fractioned JJ cord-328352-l1q4uvxl 35 12 , , , cord-328352-l1q4uvxl 35 13 antibodies antibody NNS cord-328352-l1q4uvxl 35 14 , , , cord-328352-l1q4uvxl 35 15 along along IN cord-328352-l1q4uvxl 35 16 with with IN cord-328352-l1q4uvxl 35 17 other other JJ cord-328352-l1q4uvxl 35 18 immunoglobulins immunoglobulin NNS cord-328352-l1q4uvxl 35 19 ( ( -LRB- cord-328352-l1q4uvxl 35 20 IGs IGs NNP cord-328352-l1q4uvxl 35 21 ) ) -RRB- cord-328352-l1q4uvxl 35 22 and and CC cord-328352-l1q4uvxl 35 23 possibly possibly RB cord-328352-l1q4uvxl 35 24 other other JJ cord-328352-l1q4uvxl 35 25 therapeutic therapeutic JJ cord-328352-l1q4uvxl 35 26 molecules molecule NNS cord-328352-l1q4uvxl 35 27 harvested harvest VBN cord-328352-l1q4uvxl 35 28 from from IN cord-328352-l1q4uvxl 35 29 immunized immunize VBN cord-328352-l1q4uvxl 35 30 individuals individual NNS cord-328352-l1q4uvxl 35 31 or or CC cord-328352-l1q4uvxl 35 32 convalescent convalescent JJ cord-328352-l1q4uvxl 35 33 persons person NNS cord-328352-l1q4uvxl 35 34 19 19 CD cord-328352-l1q4uvxl 35 35 . . . cord-328352-l1q4uvxl 36 1 Plasma plasma NN cord-328352-l1q4uvxl 36 2 therapy therapy NN cord-328352-l1q4uvxl 36 3 has have VBZ cord-328352-l1q4uvxl 36 4 a a DT cord-328352-l1q4uvxl 36 5 long long JJ cord-328352-l1q4uvxl 36 6 history history NN cord-328352-l1q4uvxl 36 7 of of IN cord-328352-l1q4uvxl 36 8 safety safety NN cord-328352-l1q4uvxl 36 9 , , , cord-328352-l1q4uvxl 36 10 and and CC cord-328352-l1q4uvxl 36 11 even even RB cord-328352-l1q4uvxl 36 12 efficacy efficacy NN cord-328352-l1q4uvxl 36 13 , , , cord-328352-l1q4uvxl 36 14 since since IN cord-328352-l1q4uvxl 36 15 the the DT cord-328352-l1q4uvxl 36 16 Spanish spanish JJ cord-328352-l1q4uvxl 36 17 flu flu NN cord-328352-l1q4uvxl 36 18 in in IN cord-328352-l1q4uvxl 36 19 1917 1917 CD cord-328352-l1q4uvxl 36 20 - - SYM cord-328352-l1q4uvxl 36 21 1918 1918 CD cord-328352-l1q4uvxl 36 22 19 19 CD cord-328352-l1q4uvxl 36 23 , , , cord-328352-l1q4uvxl 36 24 20 20 CD cord-328352-l1q4uvxl 36 25 . . . cord-328352-l1q4uvxl 37 1 While while IN cord-328352-l1q4uvxl 37 2 the the DT cord-328352-l1q4uvxl 37 3 mechanism mechanism NN cord-328352-l1q4uvxl 37 4 of of IN cord-328352-l1q4uvxl 37 5 action action NN cord-328352-l1q4uvxl 37 6 of of IN cord-328352-l1q4uvxl 37 7 plasma plasma NN cord-328352-l1q4uvxl 37 8 therapy therapy NN cord-328352-l1q4uvxl 37 9 remains remain VBZ cord-328352-l1q4uvxl 37 10 not not RB cord-328352-l1q4uvxl 37 11 fully fully RB cord-328352-l1q4uvxl 37 12 understood understand VBN cord-328352-l1q4uvxl 37 13 , , , cord-328352-l1q4uvxl 37 14 the the DT cord-328352-l1q4uvxl 37 15 functional functional JJ cord-328352-l1q4uvxl 37 16 benefits benefit NNS cord-328352-l1q4uvxl 37 17 have have VBP cord-328352-l1q4uvxl 37 18 been be VBN cord-328352-l1q4uvxl 37 19 largely largely RB cord-328352-l1q4uvxl 37 20 ascribed ascribe VBN cord-328352-l1q4uvxl 37 21 to to IN cord-328352-l1q4uvxl 37 22 the the DT cord-328352-l1q4uvxl 37 23 purified purify VBN cord-328352-l1q4uvxl 37 24 neutralizing neutralize VBG cord-328352-l1q4uvxl 37 25 antibodies antibody NNS cord-328352-l1q4uvxl 37 26 of of IN cord-328352-l1q4uvxl 37 27 the the DT cord-328352-l1q4uvxl 37 28 convalescent convalescent JJ cord-328352-l1q4uvxl 37 29 plasma plasma NN cord-328352-l1q4uvxl 37 30 19 19 CD cord-328352-l1q4uvxl 37 31 , , , cord-328352-l1q4uvxl 37 32 20 20 CD cord-328352-l1q4uvxl 37 33 . . . cord-328352-l1q4uvxl 38 1 A a DT cord-328352-l1q4uvxl 38 2 meta meta JJ cord-328352-l1q4uvxl 38 3 - - HYPH cord-328352-l1q4uvxl 38 4 analysis analysis NN cord-328352-l1q4uvxl 38 5 of of IN cord-328352-l1q4uvxl 38 6 English english JJ cord-328352-l1q4uvxl 38 7 - - HYPH cord-328352-l1q4uvxl 38 8 language language NN cord-328352-l1q4uvxl 38 9 journals journal NNS cord-328352-l1q4uvxl 38 10 from from IN cord-328352-l1q4uvxl 38 11 1918 1918 CD cord-328352-l1q4uvxl 38 12 to to IN cord-328352-l1q4uvxl 38 13 1925 1925 CD cord-328352-l1q4uvxl 38 14 reveals reveal VBZ cord-328352-l1q4uvxl 38 15 that that IN cord-328352-l1q4uvxl 38 16 the the DT cord-328352-l1q4uvxl 38 17 overall overall JJ cord-328352-l1q4uvxl 38 18 mortality mortality NN cord-328352-l1q4uvxl 38 19 rate rate NN cord-328352-l1q4uvxl 38 20 was be VBD cord-328352-l1q4uvxl 38 21 16 16 CD cord-328352-l1q4uvxl 38 22 % % NN cord-328352-l1q4uvxl 38 23 among among IN cord-328352-l1q4uvxl 38 24 treated treat VBN cord-328352-l1q4uvxl 38 25 patients patient NNS cord-328352-l1q4uvxl 38 26 compared compare VBN cord-328352-l1q4uvxl 38 27 to to IN cord-328352-l1q4uvxl 38 28 37 37 CD cord-328352-l1q4uvxl 38 29 % % NN cord-328352-l1q4uvxl 38 30 among among IN cord-328352-l1q4uvxl 38 31 controls control NNS cord-328352-l1q4uvxl 38 32 , , , cord-328352-l1q4uvxl 38 33 indicating indicate VBG cord-328352-l1q4uvxl 38 34 difference difference NN cord-328352-l1q4uvxl 38 35 in in IN cord-328352-l1q4uvxl 38 36 fatality fatality NN cord-328352-l1q4uvxl 38 37 between between IN cord-328352-l1q4uvxl 38 38 the the DT cord-328352-l1q4uvxl 38 39 treatment treatment NN cord-328352-l1q4uvxl 38 40 and and CC cord-328352-l1q4uvxl 38 41 control control NN cord-328352-l1q4uvxl 38 42 groups group NNS cord-328352-l1q4uvxl 38 43 at at IN cord-328352-l1q4uvxl 38 44 8 8 CD cord-328352-l1q4uvxl 38 45 % % NN cord-328352-l1q4uvxl 38 46 to to IN cord-328352-l1q4uvxl 38 47 26 26 CD cord-328352-l1q4uvxl 38 48 % % NN cord-328352-l1q4uvxl 38 49 20 20 CD cord-328352-l1q4uvxl 38 50 . . . cord-328352-l1q4uvxl 39 1 Note note VB cord-328352-l1q4uvxl 39 2 that that IN cord-328352-l1q4uvxl 39 3 the the DT cord-328352-l1q4uvxl 39 4 meta meta NNP cord-328352-l1q4uvxl 39 5 - - HYPH cord-328352-l1q4uvxl 39 6 analysis analysis NN cord-328352-l1q4uvxl 39 7 study study NN cord-328352-l1q4uvxl 39 8 20 20 CD cord-328352-l1q4uvxl 39 9 was be VBD cord-328352-l1q4uvxl 39 10 based base VBN cord-328352-l1q4uvxl 39 11 on on IN cord-328352-l1q4uvxl 39 12 only only RB cord-328352-l1q4uvxl 39 13 eight eight CD cord-328352-l1q4uvxl 39 14 studies study NNS cord-328352-l1q4uvxl 39 15 with with IN cord-328352-l1q4uvxl 39 16 many many JJ cord-328352-l1q4uvxl 39 17 methodologic methodologic JJ cord-328352-l1q4uvxl 39 18 limitations limitation NNS cord-328352-l1q4uvxl 39 19 , , , cord-328352-l1q4uvxl 39 20 including include VBG cord-328352-l1q4uvxl 39 21 lack lack NN cord-328352-l1q4uvxl 39 22 of of IN cord-328352-l1q4uvxl 39 23 blinding blind VBG cord-328352-l1q4uvxl 39 24 , , , cord-328352-l1q4uvxl 39 25 randomization randomization NN cord-328352-l1q4uvxl 39 26 , , , cord-328352-l1q4uvxl 39 27 or or CC cord-328352-l1q4uvxl 39 28 placebo placebo NN cord-328352-l1q4uvxl 39 29 - - HYPH cord-328352-l1q4uvxl 39 30 controlled control VBN cord-328352-l1q4uvxl 39 31 arm arm NN cord-328352-l1q4uvxl 39 32 . . . cord-328352-l1q4uvxl 40 1 Subsequent subsequent JJ cord-328352-l1q4uvxl 40 2 to to IN cord-328352-l1q4uvxl 40 3 the the DT cord-328352-l1q4uvxl 40 4 Spanish spanish JJ cord-328352-l1q4uvxl 40 5 flu flu NN cord-328352-l1q4uvxl 40 6 pandemic pandemic NN cord-328352-l1q4uvxl 40 7 , , , cord-328352-l1q4uvxl 40 8 the the DT cord-328352-l1q4uvxl 40 9 treatment treatment NN cord-328352-l1q4uvxl 40 10 with with IN cord-328352-l1q4uvxl 40 11 convalescent convalescent JJ cord-328352-l1q4uvxl 40 12 plasma plasma NN cord-328352-l1q4uvxl 40 13 has have VBZ cord-328352-l1q4uvxl 40 14 been be VBN cord-328352-l1q4uvxl 40 15 studied study VBN cord-328352-l1q4uvxl 40 16 in in IN cord-328352-l1q4uvxl 40 17 similar similar JJ cord-328352-l1q4uvxl 40 18 outbreaks outbreak NNS cord-328352-l1q4uvxl 40 19 of of IN cord-328352-l1q4uvxl 40 20 respiratory respiratory JJ cord-328352-l1q4uvxl 40 21 infections infection NNS cord-328352-l1q4uvxl 40 22 , , , cord-328352-l1q4uvxl 40 23 such such JJ cord-328352-l1q4uvxl 40 24 as as IN cord-328352-l1q4uvxl 40 25 the the DT cord-328352-l1q4uvxl 40 26 2003 2003 CD cord-328352-l1q4uvxl 40 27 SARS SARS NNP cord-328352-l1q4uvxl 40 28 - - HYPH cord-328352-l1q4uvxl 40 29 CoV-1 CoV-1 NNP cord-328352-l1q4uvxl 40 30 epidemic epidemic NN cord-328352-l1q4uvxl 40 31 , , , cord-328352-l1q4uvxl 40 32 the the DT cord-328352-l1q4uvxl 40 33 2009 2009 CD cord-328352-l1q4uvxl 40 34 - - SYM cord-328352-l1q4uvxl 40 35 2010 2010 CD cord-328352-l1q4uvxl 40 36 H1N1 H1N1 NNP cord-328352-l1q4uvxl 40 37 influenza influenza NN cord-328352-l1q4uvxl 40 38 virus virus NN cord-328352-l1q4uvxl 40 39 pandemic pandemic NN cord-328352-l1q4uvxl 40 40 , , , cord-328352-l1q4uvxl 40 41 and and CC cord-328352-l1q4uvxl 40 42 the the DT cord-328352-l1q4uvxl 40 43 2012 2012 CD cord-328352-l1q4uvxl 40 44 MERS MERS NNP cord-328352-l1q4uvxl 40 45 - - HYPH cord-328352-l1q4uvxl 40 46 CoV CoV NNP cord-328352-l1q4uvxl 40 47 epidemic epidemic NN cord-328352-l1q4uvxl 40 48 19 19 CD cord-328352-l1q4uvxl 40 49 , , , cord-328352-l1q4uvxl 40 50 20 20 CD cord-328352-l1q4uvxl 40 51 . . . cord-328352-l1q4uvxl 41 1 Whereas whereas IN cord-328352-l1q4uvxl 41 2 small small JJ cord-328352-l1q4uvxl 41 3 clinical clinical JJ cord-328352-l1q4uvxl 41 4 trials trial NNS cord-328352-l1q4uvxl 41 5 and and CC cord-328352-l1q4uvxl 41 6 anecdotal anecdotal JJ cord-328352-l1q4uvxl 41 7 accounts account NNS cord-328352-l1q4uvxl 41 8 of of IN cord-328352-l1q4uvxl 41 9 convalescent convalescent JJ cord-328352-l1q4uvxl 41 10 plasma plasma NN cord-328352-l1q4uvxl 41 11 suggest suggest VBP cord-328352-l1q4uvxl 41 12 safety safety NN cord-328352-l1q4uvxl 41 13 and and CC cord-328352-l1q4uvxl 41 14 efficacy efficacy NN cord-328352-l1q4uvxl 41 15 of of IN cord-328352-l1q4uvxl 41 16 plasma plasma NN cord-328352-l1q4uvxl 41 17 treatment treatment NN cord-328352-l1q4uvxl 41 18 in in IN cord-328352-l1q4uvxl 41 19 these these DT cord-328352-l1q4uvxl 41 20 previous previous JJ cord-328352-l1q4uvxl 41 21 outbreaks outbreak NNS cord-328352-l1q4uvxl 41 22 21 21 CD cord-328352-l1q4uvxl 41 23 , , , cord-328352-l1q4uvxl 41 24 its -PRON- PRP$ cord-328352-l1q4uvxl 41 25 potency potency NN cord-328352-l1q4uvxl 41 26 in in IN cord-328352-l1q4uvxl 41 27 COVID-19 COVID-19 NNP cord-328352-l1q4uvxl 41 28 requires require VBZ cord-328352-l1q4uvxl 41 29 carefully carefully RB cord-328352-l1q4uvxl 41 30 designed design VBN cord-328352-l1q4uvxl 41 31 and and CC cord-328352-l1q4uvxl 41 32 rigorous rigorous JJ cord-328352-l1q4uvxl 41 33 assessment assessment NN cord-328352-l1q4uvxl 41 34 of of IN cord-328352-l1q4uvxl 41 35 these these DT cord-328352-l1q4uvxl 41 36 clinical clinical JJ cord-328352-l1q4uvxl 41 37 trials trial NNS cord-328352-l1q4uvxl 41 38 as as IN cord-328352-l1q4uvxl 41 39 discussed discuss VBN cord-328352-l1q4uvxl 41 40 subsequently subsequently RB cord-328352-l1q4uvxl 41 41 . . . cord-328352-l1q4uvxl 42 1 The the DT cord-328352-l1q4uvxl 42 2 still still RB cord-328352-l1q4uvxl 42 3 limited limited JJ cord-328352-l1q4uvxl 42 4 evidence evidence NN cord-328352-l1q4uvxl 42 5 but but CC cord-328352-l1q4uvxl 42 6 massively massively RB cord-328352-l1q4uvxl 42 7 accumulating accumulate VBG cord-328352-l1q4uvxl 42 8 interest interest NN cord-328352-l1q4uvxl 42 9 in in IN cord-328352-l1q4uvxl 42 10 the the DT cord-328352-l1q4uvxl 42 11 safety safety NN cord-328352-l1q4uvxl 42 12 and and CC cord-328352-l1q4uvxl 42 13 efficacy efficacy NN cord-328352-l1q4uvxl 42 14 of of IN cord-328352-l1q4uvxl 42 15 convalescent convalescent JJ cord-328352-l1q4uvxl 42 16 plasma plasma NN cord-328352-l1q4uvxl 42 17 treatments treatment NNS cord-328352-l1q4uvxl 42 18 may may MD cord-328352-l1q4uvxl 42 19 provide provide VB cord-328352-l1q4uvxl 42 20 the the DT cord-328352-l1q4uvxl 42 21 basis basis NN cord-328352-l1q4uvxl 42 22 for for IN cord-328352-l1q4uvxl 42 23 compassionate compassionate JJ cord-328352-l1q4uvxl 42 24 use use NN cord-328352-l1q4uvxl 42 25 of of IN cord-328352-l1q4uvxl 42 26 these these DT cord-328352-l1q4uvxl 42 27 therapies therapy NNS cord-328352-l1q4uvxl 42 28 for for IN cord-328352-l1q4uvxl 42 29 COVID-19 covid-19 CD cord-328352-l1q4uvxl 42 30 in in IN cord-328352-l1q4uvxl 42 31 the the DT cord-328352-l1q4uvxl 42 32 United United NNP cord-328352-l1q4uvxl 42 33 States States NNP cord-328352-l1q4uvxl 42 34 . . . cord-328352-l1q4uvxl 43 1 Indeed indeed RB cord-328352-l1q4uvxl 43 2 , , , cord-328352-l1q4uvxl 43 3 a a DT cord-328352-l1q4uvxl 43 4 review review NN cord-328352-l1q4uvxl 43 5 of of IN cord-328352-l1q4uvxl 43 6 the the DT cord-328352-l1q4uvxl 43 7 literature literature NN cord-328352-l1q4uvxl 43 8 from from IN cord-328352-l1q4uvxl 43 9 2020 2020 CD cord-328352-l1q4uvxl 43 10 alone alone RB cord-328352-l1q4uvxl 43 11 shows show VBZ cord-328352-l1q4uvxl 43 12 that that IN cord-328352-l1q4uvxl 43 13 there there EX cord-328352-l1q4uvxl 43 14 are be VBP cord-328352-l1q4uvxl 43 15 already already RB cord-328352-l1q4uvxl 43 16 152 152 CD cord-328352-l1q4uvxl 43 17 publications publication NNS cord-328352-l1q4uvxl 43 18 , , , cord-328352-l1q4uvxl 43 19 although although IN cord-328352-l1q4uvxl 43 20 most most JJS cord-328352-l1q4uvxl 43 21 are be VBP cord-328352-l1q4uvxl 43 22 review review NN cord-328352-l1q4uvxl 43 23 and and CC cord-328352-l1q4uvxl 43 24 commentary commentary NN cord-328352-l1q4uvxl 43 25 articles article NNS cord-328352-l1q4uvxl 43 26 , , , cord-328352-l1q4uvxl 43 27 and and CC cord-328352-l1q4uvxl 43 28 protocol protocol NN cord-328352-l1q4uvxl 43 29 descriptions description NNS cord-328352-l1q4uvxl 43 30 , , , cord-328352-l1q4uvxl 43 31 on on IN cord-328352-l1q4uvxl 43 32 the the DT cord-328352-l1q4uvxl 43 33 theme theme NN cord-328352-l1q4uvxl 43 34 of of IN cord-328352-l1q4uvxl 43 35 convalescent convalescent JJ cord-328352-l1q4uvxl 43 36 plasma plasma NN cord-328352-l1q4uvxl 43 37 treatments treatment NNS cord-328352-l1q4uvxl 43 38 for for IN cord-328352-l1q4uvxl 43 39 COVID-19 covid-19 NN cord-328352-l1q4uvxl 43 40 . . . cord-328352-l1q4uvxl 44 1 Notable notable JJ cord-328352-l1q4uvxl 44 2 clinical clinical JJ cord-328352-l1q4uvxl 44 3 research research NN cord-328352-l1q4uvxl 44 4 reports report NNS cord-328352-l1q4uvxl 44 5 include include VBP cord-328352-l1q4uvxl 44 6 : : : cord-328352-l1q4uvxl 44 7 ( ( -LRB- cord-328352-l1q4uvxl 44 8 1 1 LS cord-328352-l1q4uvxl 44 9 ) ) -RRB- cord-328352-l1q4uvxl 45 1 The the DT cord-328352-l1q4uvxl 45 2 small small JJ cord-328352-l1q4uvxl 45 3 study study NN cord-328352-l1q4uvxl 45 4 on on IN cord-328352-l1q4uvxl 45 5 six six CD cord-328352-l1q4uvxl 45 6 Chinese chinese JJ cord-328352-l1q4uvxl 45 7 patients patient NNS cord-328352-l1q4uvxl 45 8 diagnosed diagnose VBN cord-328352-l1q4uvxl 45 9 with with IN cord-328352-l1q4uvxl 45 10 COVID-19 COVID-19 NNP cord-328352-l1q4uvxl 45 11 , , , cord-328352-l1q4uvxl 45 12 who who WP cord-328352-l1q4uvxl 45 13 subsequently subsequently RB cord-328352-l1q4uvxl 45 14 received receive VBD cord-328352-l1q4uvxl 45 15 ABO ABO NNP cord-328352-l1q4uvxl 45 16 - - HYPH cord-328352-l1q4uvxl 45 17 compatible compatible JJ cord-328352-l1q4uvxl 45 18 convalescent convalescent JJ cord-328352-l1q4uvxl 45 19 plasma plasma NN cord-328352-l1q4uvxl 45 20 , , , cord-328352-l1q4uvxl 45 21 demonstrating demonstrate VBG cord-328352-l1q4uvxl 45 22 immediate immediate JJ cord-328352-l1q4uvxl 45 23 increase increase NN cord-328352-l1q4uvxl 45 24 of of IN cord-328352-l1q4uvxl 45 25 antibody antibody NN cord-328352-l1q4uvxl 45 26 titers titer NNS cord-328352-l1q4uvxl 45 27 in in IN cord-328352-l1q4uvxl 45 28 two two CD cord-328352-l1q4uvxl 45 29 patients patient NNS cord-328352-l1q4uvxl 45 30 and and CC cord-328352-l1q4uvxl 45 31 elimination elimination NN cord-328352-l1q4uvxl 45 32 of of IN cord-328352-l1q4uvxl 45 33 the the DT cord-328352-l1q4uvxl 45 34 virus virus NN cord-328352-l1q4uvxl 45 35 in in IN cord-328352-l1q4uvxl 45 36 two two CD cord-328352-l1q4uvxl 45 37 other other JJ cord-328352-l1q4uvxl 45 38 patients patient NNS cord-328352-l1q4uvxl 45 39 22 22 CD cord-328352-l1q4uvxl 45 40 . . . cord-328352-l1q4uvxl 46 1 ( ( -LRB- cord-328352-l1q4uvxl 46 2 2 2 LS cord-328352-l1q4uvxl 46 3 ) ) -RRB- cord-328352-l1q4uvxl 47 1 Another another DT cord-328352-l1q4uvxl 47 2 small small JJ cord-328352-l1q4uvxl 47 3 study study NN cord-328352-l1q4uvxl 47 4 on on IN cord-328352-l1q4uvxl 47 5 ten ten CD cord-328352-l1q4uvxl 47 6 severe severe JJ cord-328352-l1q4uvxl 47 7 COVID-19 covid-19 JJ cord-328352-l1q4uvxl 47 8 Chinese chinese JJ cord-328352-l1q4uvxl 47 9 patients patient NNS cord-328352-l1q4uvxl 47 10 revealed reveal VBD cord-328352-l1q4uvxl 47 11 that that IN cord-328352-l1q4uvxl 47 12 nine nine CD cord-328352-l1q4uvxl 47 13 patients patient NNS cord-328352-l1q4uvxl 47 14 displayed display VBD cord-328352-l1q4uvxl 47 15 increased increase VBN cord-328352-l1q4uvxl 47 16 neutralizing neutralize VBG cord-328352-l1q4uvxl 47 17 antibody antibody NN cord-328352-l1q4uvxl 47 18 titers titer NNS cord-328352-l1q4uvxl 47 19 , , , cord-328352-l1q4uvxl 47 20 and and CC cord-328352-l1q4uvxl 47 21 the the DT cord-328352-l1q4uvxl 47 22 viral viral JJ cord-328352-l1q4uvxl 47 23 load load NN cord-328352-l1q4uvxl 47 24 in in IN cord-328352-l1q4uvxl 47 25 seven seven CD cord-328352-l1q4uvxl 47 26 patients patient NNS cord-328352-l1q4uvxl 47 27 becoming become VBG cord-328352-l1q4uvxl 47 28 undetectable undetectable JJ cord-328352-l1q4uvxl 47 29 by by IN cord-328352-l1q4uvxl 47 30 day day NN cord-328352-l1q4uvxl 47 31 seven seven CD cord-328352-l1q4uvxl 47 32 post post JJ cord-328352-l1q4uvxl 47 33 - - JJ cord-328352-l1q4uvxl 47 34 infusion infusion NN cord-328352-l1q4uvxl 47 35 of of IN cord-328352-l1q4uvxl 47 36 convalescent convalescent JJ cord-328352-l1q4uvxl 47 37 plasma plasma NN cord-328352-l1q4uvxl 47 38 , , , cord-328352-l1q4uvxl 47 39 but but CC cord-328352-l1q4uvxl 47 40 only only RB cord-328352-l1q4uvxl 47 41 3 3 CD cord-328352-l1q4uvxl 47 42 exhibited exhibit VBD cord-328352-l1q4uvxl 47 43 improved improved JJ cord-328352-l1q4uvxl 47 44 respiratory respiratory JJ cord-328352-l1q4uvxl 47 45 function function NN cord-328352-l1q4uvxl 47 46 23 23 CD cord-328352-l1q4uvxl 47 47 . . . cord-328352-l1q4uvxl 48 1 ( ( -LRB- cord-328352-l1q4uvxl 48 2 3 3 LS cord-328352-l1q4uvxl 48 3 ) ) -RRB- cord-328352-l1q4uvxl 49 1 Another another DT cord-328352-l1q4uvxl 49 2 study study NN cord-328352-l1q4uvxl 49 3 on on IN cord-328352-l1q4uvxl 49 4 five five CD cord-328352-l1q4uvxl 49 5 critically critically RB cord-328352-l1q4uvxl 49 6 ill ill JJ cord-328352-l1q4uvxl 50 1 COVID-19 covid-19 JJ cord-328352-l1q4uvxl 50 2 patients patient NNS cord-328352-l1q4uvxl 50 3 revealed reveal VBD cord-328352-l1q4uvxl 50 4 viral viral JJ cord-328352-l1q4uvxl 50 5 loads load NNS cord-328352-l1q4uvxl 50 6 decreased decrease VBD cord-328352-l1q4uvxl 50 7 and and CC cord-328352-l1q4uvxl 50 8 became become VBD cord-328352-l1q4uvxl 50 9 negative negative JJ cord-328352-l1q4uvxl 50 10 by by IN cord-328352-l1q4uvxl 50 11 day day NN cord-328352-l1q4uvxl 50 12 12 12 CD cord-328352-l1q4uvxl 50 13 , , , cord-328352-l1q4uvxl 50 14 and and CC cord-328352-l1q4uvxl 50 15 three three CD cord-328352-l1q4uvxl 50 16 patients patient NNS cord-328352-l1q4uvxl 50 17 were be VBD cord-328352-l1q4uvxl 50 18 discharged discharge VBN cord-328352-l1q4uvxl 50 19 by by IN cord-328352-l1q4uvxl 50 20 about about RB cord-328352-l1q4uvxl 50 21 50 50 CD cord-328352-l1q4uvxl 50 22 days day NNS cord-328352-l1q4uvxl 50 23 , , , cord-328352-l1q4uvxl 50 24 while while IN cord-328352-l1q4uvxl 50 25 2 2 CD cord-328352-l1q4uvxl 50 26 patients patient NNS cord-328352-l1q4uvxl 50 27 remained remain VBD cord-328352-l1q4uvxl 50 28 in in IN cord-328352-l1q4uvxl 50 29 stable stable JJ cord-328352-l1q4uvxl 50 30 condition condition NN cord-328352-l1q4uvxl 50 31 at at IN cord-328352-l1q4uvxl 50 32 37 37 CD cord-328352-l1q4uvxl 50 33 days day NNS cord-328352-l1q4uvxl 50 34 after after IN cord-328352-l1q4uvxl 50 35 convalescent convalescent JJ cord-328352-l1q4uvxl 50 36 plasma plasma NN cord-328352-l1q4uvxl 50 37 infusion infusion NN cord-328352-l1q4uvxl 50 38 24 24 CD cord-328352-l1q4uvxl 50 39 . . . cord-328352-l1q4uvxl 51 1 ( ( -LRB- cord-328352-l1q4uvxl 51 2 4 4 LS cord-328352-l1q4uvxl 51 3 ) ) -RRB- cord-328352-l1q4uvxl 52 1 In in IN cord-328352-l1q4uvxl 52 2 six six CD cord-328352-l1q4uvxl 52 3 end end NN cord-328352-l1q4uvxl 52 4 - - HYPH cord-328352-l1q4uvxl 52 5 stage stage NN cord-328352-l1q4uvxl 52 6 COVID-19 covid-19 CD cord-328352-l1q4uvxl 52 7 patients patient NNS cord-328352-l1q4uvxl 52 8 , , , cord-328352-l1q4uvxl 52 9 convalescent convalescent JJ cord-328352-l1q4uvxl 52 10 plasma plasma NN cord-328352-l1q4uvxl 52 11 effectively effectively RB cord-328352-l1q4uvxl 52 12 induced induce VBD cord-328352-l1q4uvxl 52 13 viral viral JJ cord-328352-l1q4uvxl 52 14 shedding shed VBG cord-328352-l1q4uvxl 52 15 with with IN cord-328352-l1q4uvxl 52 16 the the DT cord-328352-l1q4uvxl 52 17 SARS SARS NNP cord-328352-l1q4uvxl 52 18 - - HYPH cord-328352-l1q4uvxl 52 19 CoV-2 CoV-2 NNP cord-328352-l1q4uvxl 52 20 RNA RNA NNP cord-328352-l1q4uvxl 52 21 undetectable undetectable JJ cord-328352-l1q4uvxl 52 22 by by IN cord-328352-l1q4uvxl 52 23 day day NN cord-328352-l1q4uvxl 52 24 3 3 CD cord-328352-l1q4uvxl 52 25 post post NN cord-328352-l1q4uvxl 52 26 - - JJ cord-328352-l1q4uvxl 52 27 infusion infusion NN cord-328352-l1q4uvxl 52 28 of of IN cord-328352-l1q4uvxl 52 29 convalescent convalescent JJ cord-328352-l1q4uvxl 52 30 plasma plasma NN cord-328352-l1q4uvxl 52 31 , , , cord-328352-l1q4uvxl 52 32 but but CC cord-328352-l1q4uvxl 52 33 five five CD cord-328352-l1q4uvxl 52 34 patients patient NNS cord-328352-l1q4uvxl 52 35 eventually eventually RB cord-328352-l1q4uvxl 52 36 died die VBD cord-328352-l1q4uvxl 52 37 25 25 CD cord-328352-l1q4uvxl 52 38 ; ; : cord-328352-l1q4uvxl 52 39 ( ( -LRB- cord-328352-l1q4uvxl 52 40 5 5 LS cord-328352-l1q4uvxl 52 41 ) ) -RRB- cord-328352-l1q4uvxl 53 1 In in IN cord-328352-l1q4uvxl 53 2 South South NNP cord-328352-l1q4uvxl 53 3 Korea Korea NNP cord-328352-l1q4uvxl 53 4 , , , cord-328352-l1q4uvxl 53 5 two two CD cord-328352-l1q4uvxl 53 6 severe severe JJ cord-328352-l1q4uvxl 53 7 COVID-19 COVID-19 NNP cord-328352-l1q4uvxl 53 8 patients patient NNS cord-328352-l1q4uvxl 53 9 treated treat VBN cord-328352-l1q4uvxl 53 10 with with IN cord-328352-l1q4uvxl 53 11 convalescent convalescent JJ cord-328352-l1q4uvxl 53 12 plasma plasma NN cord-328352-l1q4uvxl 53 13 with with IN cord-328352-l1q4uvxl 53 14 both both DT cord-328352-l1q4uvxl 53 15 showing show VBG cord-328352-l1q4uvxl 53 16 favorable favorable JJ cord-328352-l1q4uvxl 53 17 outcomes outcome NNS cord-328352-l1q4uvxl 53 18 including include VBG cord-328352-l1q4uvxl 53 19 being be VBG cord-328352-l1q4uvxl 53 20 weaned wean VBN cord-328352-l1q4uvxl 53 21 from from IN cord-328352-l1q4uvxl 53 22 mechanical mechanical JJ cord-328352-l1q4uvxl 53 23 ventilators ventilator NNS cord-328352-l1q4uvxl 53 24 and/or and/or CC cord-328352-l1q4uvxl 53 25 extubated extubate VBN cord-328352-l1q4uvxl 53 26 with with IN cord-328352-l1q4uvxl 53 27 SARS SARS NNP cord-328352-l1q4uvxl 53 28 - - HYPH cord-328352-l1q4uvxl 53 29 CoV-2 CoV-2 NNP cord-328352-l1q4uvxl 53 30 negative negative JJ cord-328352-l1q4uvxl 53 31 after after IN cord-328352-l1q4uvxl 53 32 days day NNS cord-328352-l1q4uvxl 53 33 20 20 CD cord-328352-l1q4uvxl 53 34 - - SYM cord-328352-l1q4uvxl 53 35 26 26 CD cord-328352-l1q4uvxl 53 36 of of IN cord-328352-l1q4uvxl 53 37 convalescent convalescent JJ cord-328352-l1q4uvxl 53 38 plasma plasma NN cord-328352-l1q4uvxl 53 39 infusion infusion NN cord-328352-l1q4uvxl 53 40 26 26 CD cord-328352-l1q4uvxl 53 41 . . . cord-328352-l1q4uvxl 54 1 From from IN cord-328352-l1q4uvxl 54 2 these these DT cord-328352-l1q4uvxl 54 3 five five CD cord-328352-l1q4uvxl 54 4 small small JJ cord-328352-l1q4uvxl 54 5 clinical clinical JJ cord-328352-l1q4uvxl 54 6 case case NN cord-328352-l1q4uvxl 54 7 reports report NNS cord-328352-l1q4uvxl 54 8 , , , cord-328352-l1q4uvxl 54 9 the the DT cord-328352-l1q4uvxl 54 10 following follow VBG cord-328352-l1q4uvxl 54 11 protocol protocol NN cord-328352-l1q4uvxl 54 12 specifics specific NNS cord-328352-l1q4uvxl 54 13 may may MD cord-328352-l1q4uvxl 54 14 require require VB cord-328352-l1q4uvxl 54 15 optimization optimization NN cord-328352-l1q4uvxl 54 16 in in IN cord-328352-l1q4uvxl 54 17 order order NN cord-328352-l1q4uvxl 54 18 to to TO cord-328352-l1q4uvxl 54 19 further further RB cord-328352-l1q4uvxl 54 20 assess assess VB cord-328352-l1q4uvxl 54 21 the the DT cord-328352-l1q4uvxl 54 22 safety safety NN cord-328352-l1q4uvxl 54 23 and and CC cord-328352-l1q4uvxl 54 24 efficacy efficacy NN cord-328352-l1q4uvxl 54 25 of of IN cord-328352-l1q4uvxl 54 26 convalescent convalescent JJ cord-328352-l1q4uvxl 54 27 plasma plasma NN cord-328352-l1q4uvxl 54 28 treatment treatment NN cord-328352-l1q4uvxl 54 29 for for IN cord-328352-l1q4uvxl 54 30 COVID-19 COVID-19 NNP cord-328352-l1q4uvxl 54 31 . . . cord-328352-l1q4uvxl 55 1 ( ( -LRB- cord-328352-l1q4uvxl 55 2 1 1 CD cord-328352-l1q4uvxl 55 3 ) ) -RRB- cord-328352-l1q4uvxl 56 1 The the DT cord-328352-l1q4uvxl 56 2 small small JJ cord-328352-l1q4uvxl 56 3 number number NN cord-328352-l1q4uvxl 56 4 of of IN cord-328352-l1q4uvxl 56 5 patients patient NNS cord-328352-l1q4uvxl 56 6 is be VBZ cord-328352-l1q4uvxl 56 7 clearly clearly RB cord-328352-l1q4uvxl 56 8 a a DT cord-328352-l1q4uvxl 56 9 limiting limit VBG cord-328352-l1q4uvxl 56 10 factor factor NN cord-328352-l1q4uvxl 56 11 in in IN cord-328352-l1q4uvxl 56 12 all all PDT cord-328352-l1q4uvxl 56 13 these these DT cord-328352-l1q4uvxl 56 14 studies study NNS cord-328352-l1q4uvxl 56 15 . . . cord-328352-l1q4uvxl 57 1 ( ( -LRB- cord-328352-l1q4uvxl 57 2 2 2 LS cord-328352-l1q4uvxl 57 3 ) ) -RRB- cord-328352-l1q4uvxl 58 1 Once once RB cord-328352-l1q4uvxl 58 2 the the DT cord-328352-l1q4uvxl 58 3 number number NN cord-328352-l1q4uvxl 58 4 of of IN cord-328352-l1q4uvxl 58 5 patients patient NNS cord-328352-l1q4uvxl 58 6 to to TO cord-328352-l1q4uvxl 58 7 be be VB cord-328352-l1q4uvxl 58 8 enrolled enrol VBN cord-328352-l1q4uvxl 58 9 is be VBZ cord-328352-l1q4uvxl 58 10 increased increase VBN cord-328352-l1q4uvxl 58 11 , , , cord-328352-l1q4uvxl 58 12 there there EX cord-328352-l1q4uvxl 58 13 is be VBZ cord-328352-l1q4uvxl 58 14 a a DT cord-328352-l1q4uvxl 58 15 need need NN cord-328352-l1q4uvxl 58 16 for for IN cord-328352-l1q4uvxl 58 17 proper proper JJ cord-328352-l1q4uvxl 58 18 control control NN cord-328352-l1q4uvxl 58 19 and and CC cord-328352-l1q4uvxl 58 20 randomization randomization NN cord-328352-l1q4uvxl 58 21 of of IN cord-328352-l1q4uvxl 58 22 treatments treatment NNS cord-328352-l1q4uvxl 58 23 , , , cord-328352-l1q4uvxl 58 24 as as RB cord-328352-l1q4uvxl 58 25 well well RB cord-328352-l1q4uvxl 58 26 as as IN cord-328352-l1q4uvxl 58 27 blinding blind VBG cord-328352-l1q4uvxl 58 28 of of IN cord-328352-l1q4uvxl 58 29 the the DT cord-328352-l1q4uvxl 58 30 treating treat VBG cord-328352-l1q4uvxl 58 31 physicians physician NNS cord-328352-l1q4uvxl 58 32 . . . cord-328352-l1q4uvxl 59 1 ( ( -LRB- cord-328352-l1q4uvxl 59 2 3 3 LS cord-328352-l1q4uvxl 59 3 ) ) -RRB- cord-328352-l1q4uvxl 60 1 The the DT cord-328352-l1q4uvxl 60 2 timing timing NN cord-328352-l1q4uvxl 60 3 of of IN cord-328352-l1q4uvxl 60 4 convalescent convalescent JJ cord-328352-l1q4uvxl 60 5 plasma plasma NN cord-328352-l1q4uvxl 60 6 infusion infusion NN cord-328352-l1q4uvxl 60 7 and and CC cord-328352-l1q4uvxl 60 8 its -PRON- PRP$ cord-328352-l1q4uvxl 60 9 doses dose NNS cord-328352-l1q4uvxl 60 10 and and CC cord-328352-l1q4uvxl 60 11 the the DT cord-328352-l1q4uvxl 60 12 need need NN cord-328352-l1q4uvxl 60 13 for for IN cord-328352-l1q4uvxl 60 14 booster booster NN cord-328352-l1q4uvxl 60 15 shots shot NNS cord-328352-l1q4uvxl 60 16 will will MD cord-328352-l1q4uvxl 60 17 require require VB cord-328352-l1q4uvxl 60 18 careful careful JJ cord-328352-l1q4uvxl 60 19 considerations consideration NNS cord-328352-l1q4uvxl 60 20 . . . cord-328352-l1q4uvxl 61 1 For for IN cord-328352-l1q4uvxl 61 2 example example NN cord-328352-l1q4uvxl 61 3 , , , cord-328352-l1q4uvxl 61 4 in in IN cord-328352-l1q4uvxl 61 5 Duan Duan NNP cord-328352-l1q4uvxl 61 6 's 's POS cord-328352-l1q4uvxl 61 7 study study NN cord-328352-l1q4uvxl 61 8 23 23 CD cord-328352-l1q4uvxl 61 9 , , , cord-328352-l1q4uvxl 61 10 patients patient NNS cord-328352-l1q4uvxl 61 11 were be VBD cord-328352-l1q4uvxl 61 12 infused infuse VBN cord-328352-l1q4uvxl 61 13 with with IN cord-328352-l1q4uvxl 61 14 convalescent convalescent JJ cord-328352-l1q4uvxl 61 15 plasma plasma NN cord-328352-l1q4uvxl 61 16 at at IN cord-328352-l1q4uvxl 61 17 around around IN cord-328352-l1q4uvxl 61 18 16 16 CD cord-328352-l1q4uvxl 61 19 days day NNS cord-328352-l1q4uvxl 61 20 of of IN cord-328352-l1q4uvxl 61 21 symptom symptom NN cord-328352-l1q4uvxl 61 22 onset onset NN cord-328352-l1q4uvxl 61 23 , , , cord-328352-l1q4uvxl 61 24 while while IN cord-328352-l1q4uvxl 61 25 in in IN cord-328352-l1q4uvxl 61 26 Shen Shen NNP cord-328352-l1q4uvxl 61 27 's 's POS cord-328352-l1q4uvxl 61 28 study study NN cord-328352-l1q4uvxl 61 29 24 24 CD cord-328352-l1q4uvxl 61 30 , , , cord-328352-l1q4uvxl 61 31 patients patient NNS cord-328352-l1q4uvxl 61 32 received receive VBD cord-328352-l1q4uvxl 61 33 convalescent convalescent JJ cord-328352-l1q4uvxl 61 34 plasma plasma NN cord-328352-l1q4uvxl 61 35 at at IN cord-328352-l1q4uvxl 61 36 around around IN cord-328352-l1q4uvxl 61 37 21 21 CD cord-328352-l1q4uvxl 61 38 days day NNS cord-328352-l1q4uvxl 61 39 after after IN cord-328352-l1q4uvxl 61 40 symptom symptom NN cord-328352-l1q4uvxl 61 41 onset onset NN cord-328352-l1q4uvxl 61 42 . . . cord-328352-l1q4uvxl 62 1 The the DT cord-328352-l1q4uvxl 62 2 recognition recognition NN cord-328352-l1q4uvxl 62 3 of of IN cord-328352-l1q4uvxl 62 4 positive positive JJ cord-328352-l1q4uvxl 62 5 outcomes outcome NNS cord-328352-l1q4uvxl 62 6 may may MD cord-328352-l1q4uvxl 62 7 depend depend VB cord-328352-l1q4uvxl 62 8 on on IN cord-328352-l1q4uvxl 62 9 the the DT cord-328352-l1q4uvxl 62 10 early early JJ cord-328352-l1q4uvxl 62 11 initiation initiation NN cord-328352-l1q4uvxl 62 12 of of IN cord-328352-l1q4uvxl 62 13 convalescent convalescent JJ cord-328352-l1q4uvxl 62 14 plasma plasma NN cord-328352-l1q4uvxl 62 15 infusion infusion NN cord-328352-l1q4uvxl 62 16 and and CC cord-328352-l1q4uvxl 62 17 may may MD cord-328352-l1q4uvxl 62 18 be be VB cord-328352-l1q4uvxl 62 19 the the DT cord-328352-l1q4uvxl 62 20 need need NN cord-328352-l1q4uvxl 62 21 for for IN cord-328352-l1q4uvxl 62 22 subsequent subsequent JJ cord-328352-l1q4uvxl 62 23 booster booster NN cord-328352-l1q4uvxl 62 24 treatment treatment NN cord-328352-l1q4uvxl 62 25 . . . cord-328352-l1q4uvxl 63 1 Additionally additionally RB cord-328352-l1q4uvxl 63 2 , , , cord-328352-l1q4uvxl 63 3 in in IN cord-328352-l1q4uvxl 63 4 Duan Duan NNP cord-328352-l1q4uvxl 63 5 's 's POS cord-328352-l1q4uvxl 63 6 study study NN cord-328352-l1q4uvxl 63 7 23 23 CD cord-328352-l1q4uvxl 63 8 , , , cord-328352-l1q4uvxl 63 9 one one CD cord-328352-l1q4uvxl 63 10 dose dose NN cord-328352-l1q4uvxl 63 11 of of IN cord-328352-l1q4uvxl 63 12 200 200 CD cord-328352-l1q4uvxl 63 13 ml ml NNS cord-328352-l1q4uvxl 63 14 of of IN cord-328352-l1q4uvxl 63 15 convalescent convalescent JJ cord-328352-l1q4uvxl 63 16 plasma plasma NN cord-328352-l1q4uvxl 63 17 with with IN cord-328352-l1q4uvxl 63 18 the the DT cord-328352-l1q4uvxl 63 19 neutralizing neutralize VBG cord-328352-l1q4uvxl 63 20 antibody antibody NN cord-328352-l1q4uvxl 63 21 titers titer NNS cord-328352-l1q4uvxl 63 22 above above IN cord-328352-l1q4uvxl 63 23 1:640 1:640 CD cord-328352-l1q4uvxl 63 24 was be VBD cord-328352-l1q4uvxl 63 25 specified specify VBN cord-328352-l1q4uvxl 63 26 . . . cord-328352-l1q4uvxl 64 1 In in IN cord-328352-l1q4uvxl 64 2 Shen Shen NNP cord-328352-l1q4uvxl 64 3 's 's POS cord-328352-l1q4uvxl 64 4 study study NN cord-328352-l1q4uvxl 64 5 24 24 CD cord-328352-l1q4uvxl 64 6 , , , cord-328352-l1q4uvxl 64 7 it -PRON- PRP cord-328352-l1q4uvxl 64 8 was be VBD cord-328352-l1q4uvxl 64 9 400 400 CD cord-328352-l1q4uvxl 64 10 ml ml NNS cord-328352-l1q4uvxl 64 11 of of IN cord-328352-l1q4uvxl 64 12 convalescent convalescent JJ cord-328352-l1q4uvxl 64 13 plasma plasma NN cord-328352-l1q4uvxl 64 14 with with IN cord-328352-l1q4uvxl 64 15 the the DT cord-328352-l1q4uvxl 64 16 neutralizing neutralize VBG cord-328352-l1q4uvxl 64 17 antibody antibody NN cord-328352-l1q4uvxl 64 18 titer titer NN cord-328352-l1q4uvxl 64 19 set set VBN cord-328352-l1q4uvxl 64 20 at at IN cord-328352-l1q4uvxl 64 21 1:1000 1:1000 CD cord-328352-l1q4uvxl 64 22 . . . cord-328352-l1q4uvxl 65 1 Finding find VBG cord-328352-l1q4uvxl 65 2 the the DT cord-328352-l1q4uvxl 65 3 optimal optimal JJ cord-328352-l1q4uvxl 65 4 timing timing NN cord-328352-l1q4uvxl 65 5 and and CC cord-328352-l1q4uvxl 65 6 dose dose NN cord-328352-l1q4uvxl 65 7 will will MD cord-328352-l1q4uvxl 65 8 improve improve VB cord-328352-l1q4uvxl 65 9 the the DT cord-328352-l1q4uvxl 65 10 safety safety NN cord-328352-l1q4uvxl 65 11 and and CC cord-328352-l1q4uvxl 65 12 efficacy efficacy NN cord-328352-l1q4uvxl 65 13 of of IN cord-328352-l1q4uvxl 65 14 convalescent convalescent JJ cord-328352-l1q4uvxl 65 15 plasma plasma NN cord-328352-l1q4uvxl 65 16 . . . cord-328352-l1q4uvxl 66 1 ( ( -LRB- cord-328352-l1q4uvxl 66 2 4 4 LS cord-328352-l1q4uvxl 66 3 ) ) -RRB- cord-328352-l1q4uvxl 66 4 Related relate VBN cord-328352-l1q4uvxl 66 5 to to IN cord-328352-l1q4uvxl 66 6 the the DT cord-328352-l1q4uvxl 66 7 timing timing NN cord-328352-l1q4uvxl 66 8 of of IN cord-328352-l1q4uvxl 66 9 convalescent convalescent JJ cord-328352-l1q4uvxl 66 10 plasma plasma NN cord-328352-l1q4uvxl 66 11 infusion infusion NN cord-328352-l1q4uvxl 66 12 , , , cord-328352-l1q4uvxl 66 13 the the DT cord-328352-l1q4uvxl 66 14 severity severity NN cord-328352-l1q4uvxl 66 15 of of IN cord-328352-l1q4uvxl 66 16 the the DT cord-328352-l1q4uvxl 66 17 disease disease NN cord-328352-l1q4uvxl 66 18 is be VBZ cord-328352-l1q4uvxl 66 19 likely likely JJ cord-328352-l1q4uvxl 66 20 to to TO cord-328352-l1q4uvxl 66 21 impact impact VB cord-328352-l1q4uvxl 66 22 on on IN cord-328352-l1q4uvxl 66 23 the the DT cord-328352-l1q4uvxl 66 24 treatment treatment NN cord-328352-l1q4uvxl 66 25 outcomes outcome NNS cord-328352-l1q4uvxl 66 26 . . . cord-328352-l1q4uvxl 67 1 In in IN cord-328352-l1q4uvxl 67 2 all all PDT cord-328352-l1q4uvxl 67 3 these these DT cord-328352-l1q4uvxl 67 4 five five CD cord-328352-l1q4uvxl 67 5 clinical clinical JJ cord-328352-l1q4uvxl 67 6 studies study NNS cord-328352-l1q4uvxl 67 7 , , , cord-328352-l1q4uvxl 67 8 it -PRON- PRP cord-328352-l1q4uvxl 67 9 is be VBZ cord-328352-l1q4uvxl 67 10 understandable understandable JJ cord-328352-l1q4uvxl 67 11 that that IN cord-328352-l1q4uvxl 67 12 because because IN cord-328352-l1q4uvxl 67 13 convalescent convalescent JJ cord-328352-l1q4uvxl 67 14 plasma plasma NN cord-328352-l1q4uvxl 67 15 treatment treatment NN cord-328352-l1q4uvxl 67 16 remains remain VBZ cord-328352-l1q4uvxl 67 17 experimental experimental JJ cord-328352-l1q4uvxl 67 18 , , , cord-328352-l1q4uvxl 67 19 the the DT cord-328352-l1q4uvxl 67 20 target target NN cord-328352-l1q4uvxl 67 21 population population NN cord-328352-l1q4uvxl 67 22 is be VBZ cord-328352-l1q4uvxl 67 23 initially initially RB cord-328352-l1q4uvxl 67 24 the the DT cord-328352-l1q4uvxl 67 25 severe severe JJ cord-328352-l1q4uvxl 67 26 or or CC cord-328352-l1q4uvxl 67 27 critically critically RB cord-328352-l1q4uvxl 67 28 ill ill JJ cord-328352-l1q4uvxl 67 29 patients patient NNS cord-328352-l1q4uvxl 67 30 , , , cord-328352-l1q4uvxl 67 31 who who WP cord-328352-l1q4uvxl 67 32 have have VBP cord-328352-l1q4uvxl 67 33 high high JJ cord-328352-l1q4uvxl 67 34 mortality mortality NN cord-328352-l1q4uvxl 67 35 and and CC cord-328352-l1q4uvxl 67 36 worst bad JJS cord-328352-l1q4uvxl 67 37 morbidity morbidity NN cord-328352-l1q4uvxl 67 38 , , , cord-328352-l1q4uvxl 67 39 which which WDT cord-328352-l1q4uvxl 67 40 may may MD cord-328352-l1q4uvxl 67 41 mask mask VB cord-328352-l1q4uvxl 67 42 the the DT cord-328352-l1q4uvxl 67 43 potential potential JJ cord-328352-l1q4uvxl 67 44 functional functional JJ cord-328352-l1q4uvxl 67 45 benefits benefit NNS cord-328352-l1q4uvxl 67 46 of of IN cord-328352-l1q4uvxl 67 47 the the DT cord-328352-l1q4uvxl 67 48 treatment treatment NN cord-328352-l1q4uvxl 67 49 . . . cord-328352-l1q4uvxl 68 1 Future future JJ cord-328352-l1q4uvxl 68 2 treatments treatment NNS cord-328352-l1q4uvxl 68 3 may may MD cord-328352-l1q4uvxl 68 4 need need VB cord-328352-l1q4uvxl 68 5 to to TO cord-328352-l1q4uvxl 68 6 enroll enroll VB cord-328352-l1q4uvxl 68 7 those those DT cord-328352-l1q4uvxl 68 8 mild mild JJ cord-328352-l1q4uvxl 68 9 COVID-19 covid-19 JJ cord-328352-l1q4uvxl 68 10 patients patient NNS cord-328352-l1q4uvxl 68 11 or or CC cord-328352-l1q4uvxl 68 12 those those DT cord-328352-l1q4uvxl 68 13 who who WP cord-328352-l1q4uvxl 68 14 are be VBP cord-328352-l1q4uvxl 68 15 in in IN cord-328352-l1q4uvxl 68 16 the the DT cord-328352-l1q4uvxl 68 17 early early JJ cord-328352-l1q4uvxl 68 18 stages stage NNS cord-328352-l1q4uvxl 68 19 of of IN cord-328352-l1q4uvxl 68 20 the the DT cord-328352-l1q4uvxl 68 21 disease disease NN cord-328352-l1q4uvxl 68 22 . . . cord-328352-l1q4uvxl 69 1 ( ( -LRB- cord-328352-l1q4uvxl 69 2 5 5 LS cord-328352-l1q4uvxl 69 3 ) ) -RRB- cord-328352-l1q4uvxl 70 1 The the DT cord-328352-l1q4uvxl 70 2 treatment treatment NN cord-328352-l1q4uvxl 70 3 profile profile NN cord-328352-l1q4uvxl 70 4 of of IN cord-328352-l1q4uvxl 70 5 the the DT cord-328352-l1q4uvxl 70 6 patients patient NNS cord-328352-l1q4uvxl 70 7 will will MD cord-328352-l1q4uvxl 70 8 need need VB cord-328352-l1q4uvxl 70 9 to to TO cord-328352-l1q4uvxl 70 10 be be VB cord-328352-l1q4uvxl 70 11 carefully carefully RB cord-328352-l1q4uvxl 70 12 charted chart VBN cord-328352-l1q4uvxl 70 13 , , , cord-328352-l1q4uvxl 70 14 noting note VBG cord-328352-l1q4uvxl 70 15 the the DT cord-328352-l1q4uvxl 70 16 drugs drug NNS cord-328352-l1q4uvxl 70 17 and and CC cord-328352-l1q4uvxl 70 18 ventilator ventilator NN cord-328352-l1q4uvxl 70 19 supportive supportive JJ cord-328352-l1q4uvxl 70 20 care care NN cord-328352-l1q4uvxl 70 21 among among IN cord-328352-l1q4uvxl 70 22 others other NNS cord-328352-l1q4uvxl 70 23 , , , cord-328352-l1q4uvxl 70 24 in in IN cord-328352-l1q4uvxl 70 25 order order NN cord-328352-l1q4uvxl 70 26 to to TO cord-328352-l1q4uvxl 70 27 delineate delineate VB cord-328352-l1q4uvxl 70 28 the the DT cord-328352-l1q4uvxl 70 29 true true JJ cord-328352-l1q4uvxl 70 30 effects effect NNS cord-328352-l1q4uvxl 70 31 of of IN cord-328352-l1q4uvxl 70 32 convalescent convalescent JJ cord-328352-l1q4uvxl 70 33 plasma plasma NN cord-328352-l1q4uvxl 70 34 infusion infusion NN cord-328352-l1q4uvxl 70 35 or or CC cord-328352-l1q4uvxl 70 36 the the DT cord-328352-l1q4uvxl 70 37 possibility possibility NN cord-328352-l1q4uvxl 70 38 of of IN cord-328352-l1q4uvxl 70 39 additive additive NN cord-328352-l1q4uvxl 70 40 effects effect NNS cord-328352-l1q4uvxl 70 41 of of IN cord-328352-l1q4uvxl 70 42 convalescent convalescent JJ cord-328352-l1q4uvxl 70 43 plasma plasma NN cord-328352-l1q4uvxl 70 44 with with IN cord-328352-l1q4uvxl 70 45 antiviral antiviral JJ cord-328352-l1q4uvxl 70 46 agents agent NNS cord-328352-l1q4uvxl 70 47 and and CC cord-328352-l1q4uvxl 70 48 immunomodulatory immunomodulatory JJ cord-328352-l1q4uvxl 70 49 drugs drug NNS cord-328352-l1q4uvxl 70 50 . . . cord-328352-l1q4uvxl 71 1 ( ( -LRB- cord-328352-l1q4uvxl 71 2 6 6 CD cord-328352-l1q4uvxl 71 3 ) ) -RRB- cord-328352-l1q4uvxl 72 1 The the DT cord-328352-l1q4uvxl 72 2 patient patient NN cord-328352-l1q4uvxl 72 3 's 's POS cord-328352-l1q4uvxl 72 4 preexisting preexisting JJ cord-328352-l1q4uvxl 72 5 health health NN cord-328352-l1q4uvxl 72 6 condition condition NN cord-328352-l1q4uvxl 72 7 is be VBZ cord-328352-l1q4uvxl 72 8 equally equally RB cord-328352-l1q4uvxl 72 9 an an DT cord-328352-l1q4uvxl 72 10 important important JJ cord-328352-l1q4uvxl 72 11 factor factor NN cord-328352-l1q4uvxl 72 12 in in IN cord-328352-l1q4uvxl 72 13 treatment treatment NN cord-328352-l1q4uvxl 72 14 outcomes outcome NNS cord-328352-l1q4uvxl 72 15 and and CC cord-328352-l1q4uvxl 72 16 disease disease NN cord-328352-l1q4uvxl 72 17 progression progression NN cord-328352-l1q4uvxl 72 18 . . . cord-328352-l1q4uvxl 73 1 In in IN cord-328352-l1q4uvxl 73 2 addition addition NN cord-328352-l1q4uvxl 73 3 to to IN cord-328352-l1q4uvxl 73 4 COVID-19 covid-19 VB cord-328352-l1q4uvxl 73 5 , , , cord-328352-l1q4uvxl 73 6 immune immune NN cord-328352-l1q4uvxl 73 7 - - HYPH cord-328352-l1q4uvxl 73 8 related relate VBN cord-328352-l1q4uvxl 73 9 diseases disease NNS cord-328352-l1q4uvxl 73 10 may may MD cord-328352-l1q4uvxl 73 11 worsen worsen VB cord-328352-l1q4uvxl 73 12 the the DT cord-328352-l1q4uvxl 73 13 presenting present VBG cord-328352-l1q4uvxl 73 14 pathology pathology NN cord-328352-l1q4uvxl 73 15 , , , cord-328352-l1q4uvxl 73 16 which which WDT cord-328352-l1q4uvxl 73 17 will will MD cord-328352-l1q4uvxl 73 18 likely likely RB cord-328352-l1q4uvxl 73 19 require require VB cord-328352-l1q4uvxl 73 20 not not RB cord-328352-l1q4uvxl 73 21 only only RB cord-328352-l1q4uvxl 73 22 eliminating eliminate VBG cord-328352-l1q4uvxl 73 23 SARS SARS NNP cord-328352-l1q4uvxl 73 24 - - HYPH cord-328352-l1q4uvxl 73 25 CoV-2 CoV-2 NNP cord-328352-l1q4uvxl 73 26 but but CC cord-328352-l1q4uvxl 73 27 also also RB cord-328352-l1q4uvxl 73 28 addressing address VBG cord-328352-l1q4uvxl 73 29 the the DT cord-328352-l1q4uvxl 73 30 multifactorial multifactorial JJ cord-328352-l1q4uvxl 73 31 manifestations manifestation NNS cord-328352-l1q4uvxl 73 32 of of IN cord-328352-l1q4uvxl 73 33 disease disease NN cord-328352-l1q4uvxl 73 34 . . . cord-328352-l1q4uvxl 74 1 ( ( -LRB- cord-328352-l1q4uvxl 74 2 7 7 CD cord-328352-l1q4uvxl 74 3 ) ) -RRB- cord-328352-l1q4uvxl 75 1 The the DT cord-328352-l1q4uvxl 75 2 age age NN cord-328352-l1q4uvxl 75 3 , , , cord-328352-l1q4uvxl 75 4 gender gender NN cord-328352-l1q4uvxl 75 5 , , , cord-328352-l1q4uvxl 75 6 ethnicity ethnicity NN cord-328352-l1q4uvxl 75 7 , , , cord-328352-l1q4uvxl 75 8 genetic genetic JJ cord-328352-l1q4uvxl 75 9 factors factor NNS cord-328352-l1q4uvxl 75 10 , , , cord-328352-l1q4uvxl 75 11 and and CC cord-328352-l1q4uvxl 75 12 other other JJ cord-328352-l1q4uvxl 75 13 pertinent pertinent JJ cord-328352-l1q4uvxl 75 14 patient patient NN cord-328352-l1q4uvxl 75 15 profiles profile NNS cord-328352-l1q4uvxl 75 16 will will MD cord-328352-l1q4uvxl 75 17 need need VB cord-328352-l1q4uvxl 75 18 to to TO cord-328352-l1q4uvxl 75 19 be be VB cord-328352-l1q4uvxl 75 20 factored factor VBN cord-328352-l1q4uvxl 75 21 into into IN cord-328352-l1q4uvxl 75 22 the the DT cord-328352-l1q4uvxl 75 23 final final JJ cord-328352-l1q4uvxl 75 24 analysis analysis NN cord-328352-l1q4uvxl 75 25 of of IN cord-328352-l1q4uvxl 75 26 the the DT cord-328352-l1q4uvxl 75 27 treatment treatment NN cord-328352-l1q4uvxl 75 28 outcomes outcome NNS cord-328352-l1q4uvxl 75 29 as as IN cord-328352-l1q4uvxl 75 30 this this DT cord-328352-l1q4uvxl 75 31 will will MD cord-328352-l1q4uvxl 75 32 further further RB cord-328352-l1q4uvxl 75 33 guide guide VB cord-328352-l1q4uvxl 75 34 optimization optimization NN cord-328352-l1q4uvxl 75 35 of of IN cord-328352-l1q4uvxl 75 36 the the DT cord-328352-l1q4uvxl 75 37 convalescent convalescent JJ cord-328352-l1q4uvxl 75 38 plasma plasma NN cord-328352-l1q4uvxl 75 39 treatment treatment NN cord-328352-l1q4uvxl 75 40 . . . cord-328352-l1q4uvxl 76 1 Clearly clearly RB cord-328352-l1q4uvxl 76 2 , , , cord-328352-l1q4uvxl 76 3 there there EX cord-328352-l1q4uvxl 76 4 remain remain VBP cord-328352-l1q4uvxl 76 5 several several JJ cord-328352-l1q4uvxl 76 6 factors factor NNS cord-328352-l1q4uvxl 76 7 in in IN cord-328352-l1q4uvxl 76 8 order order NN cord-328352-l1q4uvxl 76 9 to to TO cord-328352-l1q4uvxl 76 10 advance advance VB cord-328352-l1q4uvxl 76 11 the the DT cord-328352-l1q4uvxl 76 12 widespread widespread JJ cord-328352-l1q4uvxl 76 13 use use NN cord-328352-l1q4uvxl 76 14 of of IN cord-328352-l1q4uvxl 76 15 convalescent convalescent JJ cord-328352-l1q4uvxl 76 16 plasma plasma NN cord-328352-l1q4uvxl 76 17 for for IN cord-328352-l1q4uvxl 76 18 treating treat VBG cord-328352-l1q4uvxl 76 19 COVID-19 covid-19 NN cord-328352-l1q4uvxl 76 20 . . . cord-328352-l1q4uvxl 77 1 However however RB cord-328352-l1q4uvxl 77 2 , , , cord-328352-l1q4uvxl 77 3 at at IN cord-328352-l1q4uvxl 77 4 the the DT cord-328352-l1q4uvxl 77 5 minimum minimum NN cord-328352-l1q4uvxl 77 6 , , , cord-328352-l1q4uvxl 77 7 the the DT cord-328352-l1q4uvxl 77 8 transparency transparency NN cord-328352-l1q4uvxl 77 9 in in IN cord-328352-l1q4uvxl 77 10 reporting report VBG cord-328352-l1q4uvxl 77 11 the the DT cord-328352-l1q4uvxl 77 12 detailed detailed JJ cord-328352-l1q4uvxl 77 13 methods method NNS cord-328352-l1q4uvxl 77 14 and and CC cord-328352-l1q4uvxl 77 15 treatment treatment NN cord-328352-l1q4uvxl 77 16 outcomes outcome NNS cord-328352-l1q4uvxl 77 17 will will MD cord-328352-l1q4uvxl 77 18 ensure ensure VB cord-328352-l1q4uvxl 77 19 rigorous rigorous JJ cord-328352-l1q4uvxl 77 20 assessment assessment NN cord-328352-l1q4uvxl 77 21 of of IN cord-328352-l1q4uvxl 77 22 the the DT cord-328352-l1q4uvxl 77 23 true true JJ cord-328352-l1q4uvxl 77 24 functional functional JJ cord-328352-l1q4uvxl 77 25 effects effect NNS cord-328352-l1q4uvxl 77 26 of of IN cord-328352-l1q4uvxl 77 27 convalescent convalescent JJ cord-328352-l1q4uvxl 77 28 plasma plasma NN cord-328352-l1q4uvxl 77 29 . . . cord-328352-l1q4uvxl 78 1 A a DT cord-328352-l1q4uvxl 78 2 glance glance NN cord-328352-l1q4uvxl 78 3 at at IN cord-328352-l1q4uvxl 78 4 the the DT cord-328352-l1q4uvxl 78 5 clinicaltrials.gov clinicaltrials.gov NNP cord-328352-l1q4uvxl 78 6 website website NN cord-328352-l1q4uvxl 78 7 reveals reveal VBZ cord-328352-l1q4uvxl 78 8 173 173 CD cord-328352-l1q4uvxl 78 9 ongoing ongoing JJ cord-328352-l1q4uvxl 78 10 clinical clinical JJ cord-328352-l1q4uvxl 78 11 trials trial NNS cord-328352-l1q4uvxl 78 12 on on IN cord-328352-l1q4uvxl 78 13 the the DT cord-328352-l1q4uvxl 78 14 use use NN cord-328352-l1q4uvxl 78 15 of of IN cord-328352-l1q4uvxl 78 16 convalescent convalescent JJ cord-328352-l1q4uvxl 78 17 plasma plasma NN cord-328352-l1q4uvxl 78 18 for for IN cord-328352-l1q4uvxl 78 19 COVID-19 COVID-19 NNP cord-328352-l1q4uvxl 78 20 . . . cord-328352-l1q4uvxl 79 1 Recognition recognition NN cord-328352-l1q4uvxl 79 2 of of IN cord-328352-l1q4uvxl 79 3 the the DT cord-328352-l1q4uvxl 79 4 factors factor NNS cord-328352-l1q4uvxl 79 5 mentioned mention VBN cord-328352-l1q4uvxl 79 6 earlier early RBR cord-328352-l1q4uvxl 79 7 will will MD cord-328352-l1q4uvxl 79 8 allow allow VB cord-328352-l1q4uvxl 79 9 direct direct JJ cord-328352-l1q4uvxl 79 10 comparisons comparison NNS cord-328352-l1q4uvxl 79 11 of of IN cord-328352-l1q4uvxl 79 12 protocols protocol NNS cord-328352-l1q4uvxl 79 13 and and CC cord-328352-l1q4uvxl 79 14 safety safety NN cord-328352-l1q4uvxl 79 15 and and CC cord-328352-l1q4uvxl 79 16 efficacy efficacy NN cord-328352-l1q4uvxl 79 17 readouts readout NNS cord-328352-l1q4uvxl 79 18 across across IN cord-328352-l1q4uvxl 79 19 these these DT cord-328352-l1q4uvxl 79 20 clinical clinical JJ cord-328352-l1q4uvxl 79 21 trials trial NNS cord-328352-l1q4uvxl 79 22 and and CC cord-328352-l1q4uvxl 79 23 further further RB cord-328352-l1q4uvxl 79 24 evaluate evaluate VB cord-328352-l1q4uvxl 79 25 the the DT cord-328352-l1q4uvxl 79 26 potential potential NN cord-328352-l1q4uvxl 79 27 of of IN cord-328352-l1q4uvxl 79 28 convalescent convalescent JJ cord-328352-l1q4uvxl 79 29 plasma plasma NN cord-328352-l1q4uvxl 79 30 for for IN cord-328352-l1q4uvxl 79 31 COVID-19 COVID-19 NNP cord-328352-l1q4uvxl 79 32 . . . cord-328352-l1q4uvxl 80 1 As as IN cord-328352-l1q4uvxl 80 2 noted note VBN cord-328352-l1q4uvxl 80 3 earlier early RBR cord-328352-l1q4uvxl 80 4 , , , cord-328352-l1q4uvxl 80 5 plasma plasma NN cord-328352-l1q4uvxl 80 6 therapy therapy NN cord-328352-l1q4uvxl 80 7 involves involve VBZ cord-328352-l1q4uvxl 80 8 the the DT cord-328352-l1q4uvxl 80 9 use use NN cord-328352-l1q4uvxl 80 10 of of IN cord-328352-l1q4uvxl 80 11 convalescent convalescent JJ cord-328352-l1q4uvxl 80 12 plasma plasma NN cord-328352-l1q4uvxl 80 13 , , , cord-328352-l1q4uvxl 80 14 but but CC cord-328352-l1q4uvxl 80 15 also also RB cord-328352-l1q4uvxl 80 16 the the DT cord-328352-l1q4uvxl 80 17 plasma plasma NN cord-328352-l1q4uvxl 80 18 - - HYPH cord-328352-l1q4uvxl 80 19 active active JJ cord-328352-l1q4uvxl 80 20 components component NNS cord-328352-l1q4uvxl 80 21 specifically specifically RB cord-328352-l1q4uvxl 80 22 IGs IGs NNP cord-328352-l1q4uvxl 80 23 . . . cord-328352-l1q4uvxl 81 1 Under under IN cord-328352-l1q4uvxl 81 2 the the DT cord-328352-l1q4uvxl 81 3 guise guise NN cord-328352-l1q4uvxl 81 4 of of IN cord-328352-l1q4uvxl 81 5 passive passive JJ cord-328352-l1q4uvxl 81 6 immunity immunity NN cord-328352-l1q4uvxl 81 7 against against IN cord-328352-l1q4uvxl 81 8 pathogens pathogen NNS cord-328352-l1q4uvxl 81 9 in in IN cord-328352-l1q4uvxl 81 10 viral viral JJ cord-328352-l1q4uvxl 81 11 epidemics epidemic NNS cord-328352-l1q4uvxl 81 12 , , , cord-328352-l1q4uvxl 81 13 convalescent convalescent JJ cord-328352-l1q4uvxl 81 14 plasma plasma NN cord-328352-l1q4uvxl 81 15 is be VBZ cord-328352-l1q4uvxl 81 16 considered consider VBN cord-328352-l1q4uvxl 81 17 the the DT cord-328352-l1q4uvxl 81 18 first first JJ cord-328352-l1q4uvxl 81 19 - - HYPH cord-328352-l1q4uvxl 81 20 line line NN cord-328352-l1q4uvxl 81 21 passive passive JJ cord-328352-l1q4uvxl 81 22 immunotherapy immunotherapy NN cord-328352-l1q4uvxl 81 23 since since IN cord-328352-l1q4uvxl 81 24 the the DT cord-328352-l1q4uvxl 81 25 1918 1918 CD cord-328352-l1q4uvxl 81 26 Spanish spanish JJ cord-328352-l1q4uvxl 81 27 flu flu NN cord-328352-l1q4uvxl 81 28 and and CC cord-328352-l1q4uvxl 81 29 the the DT cord-328352-l1q4uvxl 81 30 modern modern JJ cord-328352-l1q4uvxl 81 31 viral viral JJ cord-328352-l1q4uvxl 81 32 epidemics epidemic NNS cord-328352-l1q4uvxl 81 33 ( ( -LRB- cord-328352-l1q4uvxl 81 34 2003 2003 CD cord-328352-l1q4uvxl 81 35 SARS SARS NNP cord-328352-l1q4uvxl 81 36 - - HYPH cord-328352-l1q4uvxl 81 37 CoV-1 CoV-1 NNP cord-328352-l1q4uvxl 81 38 , , , cord-328352-l1q4uvxl 81 39 2009 2009 CD cord-328352-l1q4uvxl 81 40 - - SYM cord-328352-l1q4uvxl 81 41 2010 2010 CD cord-328352-l1q4uvxl 81 42 H1N1 H1N1 NNP cord-328352-l1q4uvxl 81 43 , , , cord-328352-l1q4uvxl 81 44 and and CC cord-328352-l1q4uvxl 81 45 2012 2012 CD cord-328352-l1q4uvxl 81 46 MERS MERS NNP cord-328352-l1q4uvxl 81 47 - - HYPH cord-328352-l1q4uvxl 81 48 CoV CoV NNP cord-328352-l1q4uvxl 81 49 ) ) -RRB- cord-328352-l1q4uvxl 81 50 , , , cord-328352-l1q4uvxl 81 51 and and CC cord-328352-l1q4uvxl 81 52 now now RB cord-328352-l1q4uvxl 81 53 Covid-19 Covid-19 NNP cord-328352-l1q4uvxl 81 54 27 27 CD cord-328352-l1q4uvxl 81 55 , , , cord-328352-l1q4uvxl 81 56 28 28 CD cord-328352-l1q4uvxl 81 57 . . . cord-328352-l1q4uvxl 82 1 The the DT cord-328352-l1q4uvxl 82 2 last last JJ cord-328352-l1q4uvxl 82 3 several several JJ cord-328352-l1q4uvxl 82 4 decades decade NNS cord-328352-l1q4uvxl 82 5 have have VBP cord-328352-l1q4uvxl 82 6 witnessed witness VBN cord-328352-l1q4uvxl 82 7 advancements advancement NNS cord-328352-l1q4uvxl 82 8 in in IN cord-328352-l1q4uvxl 82 9 molecular molecular JJ cord-328352-l1q4uvxl 82 10 technology technology NN cord-328352-l1q4uvxl 82 11 toward toward IN cord-328352-l1q4uvxl 82 12 the the DT cord-328352-l1q4uvxl 82 13 purification purification NN cord-328352-l1q4uvxl 82 14 and and CC cord-328352-l1q4uvxl 82 15 manufacture manufacture NN cord-328352-l1q4uvxl 82 16 of of IN cord-328352-l1q4uvxl 82 17 plasma plasma NN cord-328352-l1q4uvxl 82 18 - - HYPH cord-328352-l1q4uvxl 82 19 derived derive VBN cord-328352-l1q4uvxl 82 20 IG IG NNP cord-328352-l1q4uvxl 82 21 as as IN cord-328352-l1q4uvxl 82 22 a a DT cord-328352-l1q4uvxl 82 23 drug drug NN cord-328352-l1q4uvxl 82 24 therapy therapy NN cord-328352-l1q4uvxl 82 25 27 27 CD cord-328352-l1q4uvxl 82 26 , , , cord-328352-l1q4uvxl 82 27 28 28 CD cord-328352-l1q4uvxl 82 28 . . . cord-328352-l1q4uvxl 83 1 Toward toward IN cord-328352-l1q4uvxl 83 2 this this DT cord-328352-l1q4uvxl 83 3 end end NN cord-328352-l1q4uvxl 83 4 , , , cord-328352-l1q4uvxl 83 5 human human JJ cord-328352-l1q4uvxl 83 6 IG ig NN cord-328352-l1q4uvxl 83 7 formulations formulation NNS cord-328352-l1q4uvxl 83 8 have have VBP cord-328352-l1q4uvxl 83 9 been be VBN cord-328352-l1q4uvxl 83 10 advanced advance VBN cord-328352-l1q4uvxl 83 11 as as IN cord-328352-l1q4uvxl 83 12 the the DT cord-328352-l1q4uvxl 83 13 second second JJ cord-328352-l1q4uvxl 83 14 line line NN cord-328352-l1q4uvxl 83 15 of of IN cord-328352-l1q4uvxl 83 16 passive passive JJ cord-328352-l1q4uvxl 83 17 immunotherapies immunotherapy NNS cord-328352-l1q4uvxl 83 18 against against IN cord-328352-l1q4uvxl 83 19 these these DT cord-328352-l1q4uvxl 83 20 diseases disease NNS cord-328352-l1q4uvxl 83 21 27 27 CD cord-328352-l1q4uvxl 83 22 , , , cord-328352-l1q4uvxl 83 23 28 28 CD cord-328352-l1q4uvxl 83 24 . . . cord-328352-l1q4uvxl 84 1 The the DT cord-328352-l1q4uvxl 84 2 rationale rationale NN cord-328352-l1q4uvxl 84 3 of of IN cord-328352-l1q4uvxl 84 4 human human JJ cord-328352-l1q4uvxl 84 5 IG ig NN cord-328352-l1q4uvxl 84 6 for for IN cord-328352-l1q4uvxl 84 7 intravenous intravenous JJ cord-328352-l1q4uvxl 84 8 use use NN cord-328352-l1q4uvxl 84 9 ( ( -LRB- cord-328352-l1q4uvxl 84 10 IVIG IVIG NNP cord-328352-l1q4uvxl 84 11 ) ) -RRB- cord-328352-l1q4uvxl 84 12 is be VBZ cord-328352-l1q4uvxl 84 13 thus thus RB cord-328352-l1q4uvxl 84 14 based base VBN cord-328352-l1q4uvxl 84 15 on on IN cord-328352-l1q4uvxl 84 16 the the DT cord-328352-l1q4uvxl 84 17 similar similar JJ cord-328352-l1q4uvxl 84 18 etiology etiology NN cord-328352-l1q4uvxl 84 19 and and CC cord-328352-l1q4uvxl 84 20 inflammatory inflammatory JJ cord-328352-l1q4uvxl 84 21 pathogenesis pathogenesis NN cord-328352-l1q4uvxl 84 22 of of IN cord-328352-l1q4uvxl 84 23 SARS SARS NNP cord-328352-l1q4uvxl 84 24 - - HYPH cord-328352-l1q4uvxl 84 25 CoV-2 CoV-2 NNP cord-328352-l1q4uvxl 84 26 infection infection NN cord-328352-l1q4uvxl 84 27 to to IN cord-328352-l1q4uvxl 84 28 diseases disease NNS cord-328352-l1q4uvxl 84 29 for for IN cord-328352-l1q4uvxl 84 30 which which WDT cord-328352-l1q4uvxl 84 31 the the DT cord-328352-l1q4uvxl 84 32 use use NN cord-328352-l1q4uvxl 84 33 of of IN cord-328352-l1q4uvxl 84 34 IVIG IVIG NNP cord-328352-l1q4uvxl 84 35 has have VBZ cord-328352-l1q4uvxl 84 36 already already RB cord-328352-l1q4uvxl 84 37 been be VBN cord-328352-l1q4uvxl 84 38 approved approve VBN cord-328352-l1q4uvxl 84 39 by by IN cord-328352-l1q4uvxl 84 40 the the DT cord-328352-l1q4uvxl 84 41 FDA FDA NNP cord-328352-l1q4uvxl 84 42 29 29 CD cord-328352-l1q4uvxl 84 43 . . . cord-328352-l1q4uvxl 85 1 According accord VBG cord-328352-l1q4uvxl 85 2 to to IN cord-328352-l1q4uvxl 85 3 clinicaltrials.gov clinicaltrials.gov NNP cord-328352-l1q4uvxl 85 4 , , , cord-328352-l1q4uvxl 85 5 there there EX cord-328352-l1q4uvxl 85 6 are be VBP cord-328352-l1q4uvxl 85 7 40 40 CD cord-328352-l1q4uvxl 85 8 trials trial NNS cord-328352-l1q4uvxl 85 9 using use VBG cord-328352-l1q4uvxl 85 10 IG IG NNP cord-328352-l1q4uvxl 85 11 for for IN cord-328352-l1q4uvxl 85 12 COVID-19 COVID-19 NNP cord-328352-l1q4uvxl 85 13 . . . cord-328352-l1q4uvxl 86 1 Similar similar JJ cord-328352-l1q4uvxl 86 2 to to IN cord-328352-l1q4uvxl 86 3 convalescent convalescent JJ cord-328352-l1q4uvxl 86 4 plasma plasma NN cord-328352-l1q4uvxl 86 5 treatment treatment NN cord-328352-l1q4uvxl 86 6 , , , cord-328352-l1q4uvxl 86 7 the the DT cord-328352-l1q4uvxl 86 8 mechanism mechanism NN cord-328352-l1q4uvxl 86 9 of of IN cord-328352-l1q4uvxl 86 10 action action NN cord-328352-l1q4uvxl 86 11 ascribed ascribe VBN cord-328352-l1q4uvxl 86 12 to to IN cord-328352-l1q4uvxl 86 13 IG IG NNP cord-328352-l1q4uvxl 86 14 therapy therapy NN cord-328352-l1q4uvxl 86 15 is be VBZ cord-328352-l1q4uvxl 86 16 to to TO cord-328352-l1q4uvxl 86 17 boost boost VB cord-328352-l1q4uvxl 86 18 the the DT cord-328352-l1q4uvxl 86 19 immune immune JJ cord-328352-l1q4uvxl 86 20 response response NN cord-328352-l1q4uvxl 86 21 of of IN cord-328352-l1q4uvxl 86 22 the the DT cord-328352-l1q4uvxl 86 23 body body NN cord-328352-l1q4uvxl 86 24 against against IN cord-328352-l1q4uvxl 86 25 SARS SARS NNP cord-328352-l1q4uvxl 86 26 - - HYPH cord-328352-l1q4uvxl 86 27 CoV-2 CoV-2 NNP cord-328352-l1q4uvxl 86 28 . . . cord-328352-l1q4uvxl 87 1 Along along IN cord-328352-l1q4uvxl 87 2 this this DT cord-328352-l1q4uvxl 87 3 line line NN cord-328352-l1q4uvxl 87 4 of of IN cord-328352-l1q4uvxl 87 5 boosting boost VBG cord-328352-l1q4uvxl 87 6 the the DT cord-328352-l1q4uvxl 87 7 immune immune JJ cord-328352-l1q4uvxl 87 8 system system NN cord-328352-l1q4uvxl 87 9 of of IN cord-328352-l1q4uvxl 87 10 COVID-19 covid-19 JJ cord-328352-l1q4uvxl 87 11 patients patient NNS cord-328352-l1q4uvxl 87 12 , , , cord-328352-l1q4uvxl 87 13 mesenchymal mesenchymal JJ cord-328352-l1q4uvxl 87 14 stem stem NN cord-328352-l1q4uvxl 87 15 cells cell NNS cord-328352-l1q4uvxl 87 16 ( ( -LRB- cord-328352-l1q4uvxl 87 17 MSCs msc NNS cord-328352-l1q4uvxl 87 18 ) ) -RRB- cord-328352-l1q4uvxl 87 19 possess possess VB cord-328352-l1q4uvxl 87 20 secretory secretory JJ cord-328352-l1q4uvxl 87 21 functions function NNS cord-328352-l1q4uvxl 87 22 of of IN cord-328352-l1q4uvxl 87 23 robust robust JJ cord-328352-l1q4uvxl 87 24 immunomodulatory immunomodulatory JJ cord-328352-l1q4uvxl 87 25 biologics biologic NNS cord-328352-l1q4uvxl 87 26 [ [ -LRB- cord-328352-l1q4uvxl 87 27 30 30 CD cord-328352-l1q4uvxl 87 28 ] ] -RRB- cord-328352-l1q4uvxl 88 1 [ [ -LRB- cord-328352-l1q4uvxl 88 2 31 31 CD cord-328352-l1q4uvxl 88 3 ] ] -RRB- cord-328352-l1q4uvxl 88 4 [ [ -LRB- cord-328352-l1q4uvxl 88 5 32 32 CD cord-328352-l1q4uvxl 88 6 ] ] -RRB- cord-328352-l1q4uvxl 89 1 [ [ -LRB- cord-328352-l1q4uvxl 89 2 33 33 CD cord-328352-l1q4uvxl 89 3 ] ] -RRB- cord-328352-l1q4uvxl 89 4 [ [ -LRB- cord-328352-l1q4uvxl 89 5 34 34 CD cord-328352-l1q4uvxl 89 6 ] ] -RRB- cord-328352-l1q4uvxl 89 7 . . . cord-328352-l1q4uvxl 90 1 Because because IN cord-328352-l1q4uvxl 90 2 COVID-19 COVID-19 NNP cord-328352-l1q4uvxl 90 3 manifests manifest VBZ cord-328352-l1q4uvxl 90 4 a a DT cord-328352-l1q4uvxl 90 5 massive massive JJ cord-328352-l1q4uvxl 90 6 inflammatory inflammatory JJ cord-328352-l1q4uvxl 90 7 pathology pathology NN cord-328352-l1q4uvxl 90 8 in in IN cord-328352-l1q4uvxl 90 9 the the DT cord-328352-l1q4uvxl 90 10 lung lung NN cord-328352-l1q4uvxl 90 11 , , , cord-328352-l1q4uvxl 90 12 characterized characterize VBN cord-328352-l1q4uvxl 90 13 by by IN cord-328352-l1q4uvxl 90 14 pulmonary pulmonary JJ cord-328352-l1q4uvxl 90 15 edema edema NN cord-328352-l1q4uvxl 90 16 and and CC cord-328352-l1q4uvxl 90 17 an an DT cord-328352-l1q4uvxl 90 18 over over IN cord-328352-l1q4uvxl 90 19 - - HYPH cord-328352-l1q4uvxl 90 20 reactive reactive JJ cord-328352-l1q4uvxl 90 21 immune immune JJ cord-328352-l1q4uvxl 90 22 response response NN cord-328352-l1q4uvxl 90 23 , , , cord-328352-l1q4uvxl 90 24 which which WDT cord-328352-l1q4uvxl 90 25 can can MD cord-328352-l1q4uvxl 90 26 lead lead VB cord-328352-l1q4uvxl 90 27 to to IN cord-328352-l1q4uvxl 90 28 hypoxia hypoxia NN cord-328352-l1q4uvxl 90 29 , , , cord-328352-l1q4uvxl 90 30 respiratory respiratory JJ cord-328352-l1q4uvxl 90 31 distress distress NN cord-328352-l1q4uvxl 90 32 , , , cord-328352-l1q4uvxl 90 33 and and CC cord-328352-l1q4uvxl 90 34 lung lung NN cord-328352-l1q4uvxl 90 35 damage damage NN cord-328352-l1q4uvxl 90 36 , , , cord-328352-l1q4uvxl 90 37 finding find VBG cord-328352-l1q4uvxl 90 38 a a DT cord-328352-l1q4uvxl 90 39 treatment treatment NN cord-328352-l1q4uvxl 90 40 designed design VBN cord-328352-l1q4uvxl 90 41 to to TO cord-328352-l1q4uvxl 90 42 sequester sequester VB cord-328352-l1q4uvxl 90 43 this this DT cord-328352-l1q4uvxl 90 44 aberrant aberrant JJ cord-328352-l1q4uvxl 90 45 inflammation inflammation NN cord-328352-l1q4uvxl 90 46 and and CC cord-328352-l1q4uvxl 90 47 immune immune JJ cord-328352-l1q4uvxl 90 48 response response NN cord-328352-l1q4uvxl 90 49 may may MD cord-328352-l1q4uvxl 90 50 prove prove VB cord-328352-l1q4uvxl 90 51 beneficial beneficial JJ cord-328352-l1q4uvxl 90 52 against against IN cord-328352-l1q4uvxl 90 53 COVID-19 COVID-19 NNP cord-328352-l1q4uvxl 90 54 33 33 CD cord-328352-l1q4uvxl 90 55 . . . cord-328352-l1q4uvxl 91 1 Accordingly accordingly RB cord-328352-l1q4uvxl 91 2 , , , cord-328352-l1q4uvxl 91 3 cognizant cognizant JJ cord-328352-l1q4uvxl 91 4 that that IN cord-328352-l1q4uvxl 91 5 abrogating abrogate VBG cord-328352-l1q4uvxl 91 6 COVID-19 COVID-19 NNP cord-328352-l1q4uvxl 91 7 may may MD cord-328352-l1q4uvxl 91 8 depend depend VB cord-328352-l1q4uvxl 91 9 on on IN cord-328352-l1q4uvxl 91 10 the the DT cord-328352-l1q4uvxl 91 11 patients patient NNS cord-328352-l1q4uvxl 91 12 ' ' POS cord-328352-l1q4uvxl 91 13 properly properly RB cord-328352-l1q4uvxl 91 14 functioning function VBG cord-328352-l1q4uvxl 91 15 immune immune JJ cord-328352-l1q4uvxl 91 16 system system NN cord-328352-l1q4uvxl 91 17 , , , cord-328352-l1q4uvxl 91 18 the the DT cord-328352-l1q4uvxl 91 19 transplantation transplantation NN cord-328352-l1q4uvxl 91 20 of of IN cord-328352-l1q4uvxl 91 21 MSCs msc NNS cord-328352-l1q4uvxl 91 22 has have VBZ cord-328352-l1q4uvxl 91 23 been be VBN cord-328352-l1q4uvxl 91 24 proposed propose VBN cord-328352-l1q4uvxl 91 25 to to TO cord-328352-l1q4uvxl 91 26 propel propel VB cord-328352-l1q4uvxl 91 27 the the DT cord-328352-l1q4uvxl 91 28 host host NN cord-328352-l1q4uvxl 91 29 immune immune JJ cord-328352-l1q4uvxl 91 30 system system NN cord-328352-l1q4uvxl 91 31 to to TO cord-328352-l1q4uvxl 91 32 effectively effectively RB cord-328352-l1q4uvxl 91 33 eliminate eliminate VB cord-328352-l1q4uvxl 91 34 the the DT cord-328352-l1q4uvxl 91 35 virus virus NN cord-328352-l1q4uvxl 91 36 . . . cord-328352-l1q4uvxl 92 1 MSCs mscs NN cord-328352-l1q4uvxl 92 2 display display VBP cord-328352-l1q4uvxl 92 3 potent potent JJ cord-328352-l1q4uvxl 92 4 antiinflammatory antiinflammatory JJ cord-328352-l1q4uvxl 92 5 and and CC cord-328352-l1q4uvxl 92 6 immunomodulatory immunomodulatory JJ cord-328352-l1q4uvxl 92 7 properties property NNS cord-328352-l1q4uvxl 92 8 . . . cord-328352-l1q4uvxl 93 1 Indeed indeed RB cord-328352-l1q4uvxl 93 2 , , , cord-328352-l1q4uvxl 93 3 our -PRON- PRP$ cord-328352-l1q4uvxl 93 4 group group NN cord-328352-l1q4uvxl 93 5 and and CC cord-328352-l1q4uvxl 93 6 many many JJ cord-328352-l1q4uvxl 93 7 others other NNS cord-328352-l1q4uvxl 93 8 have have VBP cord-328352-l1q4uvxl 93 9 shown show VBN cord-328352-l1q4uvxl 93 10 that that IN cord-328352-l1q4uvxl 93 11 MSCs msc NNS cord-328352-l1q4uvxl 93 12 exert exert VB cord-328352-l1q4uvxl 93 13 anti anti JJ cord-328352-l1q4uvxl 93 14 - - JJ cord-328352-l1q4uvxl 93 15 inflammatory inflammatory JJ cord-328352-l1q4uvxl 93 16 effects effect NNS cord-328352-l1q4uvxl 93 17 and and CC cord-328352-l1q4uvxl 93 18 even even RB cord-328352-l1q4uvxl 93 19 repair repair VB cord-328352-l1q4uvxl 93 20 lung lung NN cord-328352-l1q4uvxl 93 21 damage damage NN cord-328352-l1q4uvxl 93 22 34 34 CD cord-328352-l1q4uvxl 93 23 . . . cord-328352-l1q4uvxl 94 1 Although although IN cord-328352-l1q4uvxl 94 2 MSCs msc NNS cord-328352-l1q4uvxl 94 3 have have VBP cord-328352-l1q4uvxl 94 4 been be VBN cord-328352-l1q4uvxl 94 5 the the DT cord-328352-l1q4uvxl 94 6 major major JJ cord-328352-l1q4uvxl 94 7 cell cell NN cord-328352-l1q4uvxl 94 8 type type NN cord-328352-l1q4uvxl 94 9 for for IN cord-328352-l1q4uvxl 94 10 cell cell NN cord-328352-l1q4uvxl 94 11 therapy therapy NN cord-328352-l1q4uvxl 94 12 in in IN cord-328352-l1q4uvxl 94 13 COVID-19 COVID-19 NNP cord-328352-l1q4uvxl 94 14 , , , cord-328352-l1q4uvxl 94 15 non non JJ cord-328352-l1q4uvxl 94 16 - - JJ cord-328352-l1q4uvxl 94 17 MSC msc JJ cord-328352-l1q4uvxl 94 18 stem stem NN cord-328352-l1q4uvxl 94 19 cells cell NNS cord-328352-l1q4uvxl 94 20 , , , cord-328352-l1q4uvxl 94 21 such such JJ cord-328352-l1q4uvxl 94 22 as as IN cord-328352-l1q4uvxl 94 23 umbilical umbilical JJ cord-328352-l1q4uvxl 94 24 cord cord NN cord-328352-l1q4uvxl 94 25 blood blood NN cord-328352-l1q4uvxl 94 26 monocytes monocyte VBZ cord-328352-l1q4uvxl 94 27 35 35 CD cord-328352-l1q4uvxl 94 28 , , , cord-328352-l1q4uvxl 94 29 36 36 CD cord-328352-l1q4uvxl 94 30 , , , cord-328352-l1q4uvxl 94 31 that that WDT cord-328352-l1q4uvxl 94 32 similarly similarly RB cord-328352-l1q4uvxl 94 33 target target VBP cord-328352-l1q4uvxl 94 34 the the DT cord-328352-l1q4uvxl 94 35 inflammatory inflammatory JJ cord-328352-l1q4uvxl 94 36 and and CC cord-328352-l1q4uvxl 94 37 immune immune JJ cord-328352-l1q4uvxl 94 38 pathways pathway NNS cord-328352-l1q4uvxl 94 39 and and CC cord-328352-l1q4uvxl 94 40 promote promote VB cord-328352-l1q4uvxl 94 41 other other JJ cord-328352-l1q4uvxl 94 42 regenerative regenerative JJ cord-328352-l1q4uvxl 94 43 mechanisms mechanism NNS cord-328352-l1q4uvxl 94 44 ( ( -LRB- cord-328352-l1q4uvxl 94 45 e.g. e.g. RB cord-328352-l1q4uvxl 94 46 , , , cord-328352-l1q4uvxl 94 47 tissue tissue NN cord-328352-l1q4uvxl 94 48 repair repair NN cord-328352-l1q4uvxl 94 49 ) ) -RRB- cord-328352-l1q4uvxl 94 50 , , , cord-328352-l1q4uvxl 94 51 are be VBP cord-328352-l1q4uvxl 94 52 also also RB cord-328352-l1q4uvxl 94 53 being be VBG cord-328352-l1q4uvxl 94 54 tested test VBN cord-328352-l1q4uvxl 94 55 . . . cord-328352-l1q4uvxl 95 1 Interestingly interestingly RB cord-328352-l1q4uvxl 95 2 , , , cord-328352-l1q4uvxl 95 3 intravenous intravenous JJ cord-328352-l1q4uvxl 95 4 administration administration NN cord-328352-l1q4uvxl 95 5 of of IN cord-328352-l1q4uvxl 95 6 MSCs MSCs NNP cord-328352-l1q4uvxl 95 7 has have VBZ cord-328352-l1q4uvxl 95 8 the the DT cord-328352-l1q4uvxl 95 9 natural natural JJ cord-328352-l1q4uvxl 95 10 preponderance preponderance NN cord-328352-l1q4uvxl 95 11 to to TO cord-328352-l1q4uvxl 95 12 migrate migrate VB cord-328352-l1q4uvxl 95 13 preferentially preferentially RB cord-328352-l1q4uvxl 95 14 to to IN cord-328352-l1q4uvxl 95 15 the the DT cord-328352-l1q4uvxl 95 16 lungs lung NNS cord-328352-l1q4uvxl 95 17 allowing allow VBG cord-328352-l1q4uvxl 95 18 for for IN cord-328352-l1q4uvxl 95 19 the the DT cord-328352-l1q4uvxl 95 20 first first JJ cord-328352-l1q4uvxl 95 21 - - HYPH cord-328352-l1q4uvxl 95 22 pass pass NN cord-328352-l1q4uvxl 95 23 treatment treatment NN cord-328352-l1q4uvxl 95 24 of of IN cord-328352-l1q4uvxl 95 25 pulmonary pulmonary JJ cord-328352-l1q4uvxl 95 26 diseases disease NNS cord-328352-l1q4uvxl 95 27 33 33 CD cord-328352-l1q4uvxl 95 28 , , , cord-328352-l1q4uvxl 95 29 34 34 CD cord-328352-l1q4uvxl 95 30 , , , cord-328352-l1q4uvxl 95 31 such such JJ cord-328352-l1q4uvxl 95 32 as as IN cord-328352-l1q4uvxl 95 33 COVID-19 COVID-19 NNP cord-328352-l1q4uvxl 95 34 . . . cord-328352-l1q4uvxl 96 1 Moreover moreover RB cord-328352-l1q4uvxl 96 2 , , , cord-328352-l1q4uvxl 96 3 the the DT cord-328352-l1q4uvxl 96 4 long long JJ cord-328352-l1q4uvxl 96 5 track track NN cord-328352-l1q4uvxl 96 6 record record NN cord-328352-l1q4uvxl 96 7 of of IN cord-328352-l1q4uvxl 96 8 safety safety NN cord-328352-l1q4uvxl 96 9 profile profile NN cord-328352-l1q4uvxl 96 10 of of IN cord-328352-l1q4uvxl 96 11 MSCs msc NNS cord-328352-l1q4uvxl 96 12 for for IN cord-328352-l1q4uvxl 96 13 hematologic hematologic JJ cord-328352-l1q4uvxl 96 14 diseases disease NNS cord-328352-l1q4uvxl 96 15 may may MD cord-328352-l1q4uvxl 96 16 expedite expedite VB cord-328352-l1q4uvxl 96 17 their -PRON- PRP$ cord-328352-l1q4uvxl 96 18 clinical clinical JJ cord-328352-l1q4uvxl 96 19 entry entry NN cord-328352-l1q4uvxl 96 20 for for IN cord-328352-l1q4uvxl 96 21 novel novel JJ cord-328352-l1q4uvxl 96 22 indications indication NNS cord-328352-l1q4uvxl 96 23 ; ; : cord-328352-l1q4uvxl 96 24 indeed indeed RB cord-328352-l1q4uvxl 96 25 , , , cord-328352-l1q4uvxl 96 26 clinicaltrials.gov clinicaltrials.gov NNP cord-328352-l1q4uvxl 96 27 reveals reveal VBZ cord-328352-l1q4uvxl 96 28 31 31 CD cord-328352-l1q4uvxl 96 29 ongoing ongoing JJ cord-328352-l1q4uvxl 96 30 studies study NNS cord-328352-l1q4uvxl 96 31 using use VBG cord-328352-l1q4uvxl 96 32 stem stem NN cord-328352-l1q4uvxl 96 33 cell cell NN cord-328352-l1q4uvxl 96 34 therapy therapy NN cord-328352-l1q4uvxl 96 35 for for IN cord-328352-l1q4uvxl 96 36 COVID-19 COVID-19 NNP cord-328352-l1q4uvxl 96 37 . . . cord-328352-l1q4uvxl 97 1 Preliminary preliminary JJ cord-328352-l1q4uvxl 97 2 reports report NNS cord-328352-l1q4uvxl 97 3 in in IN cord-328352-l1q4uvxl 97 4 China China NNP cord-328352-l1q4uvxl 97 5 and and CC cord-328352-l1q4uvxl 97 6 the the DT cord-328352-l1q4uvxl 97 7 United United NNP cord-328352-l1q4uvxl 97 8 States States NNP cord-328352-l1q4uvxl 97 9 suggest suggest VBP cord-328352-l1q4uvxl 97 10 solid solid JJ cord-328352-l1q4uvxl 97 11 safety safety NN cord-328352-l1q4uvxl 97 12 outcomes outcome NNS cord-328352-l1q4uvxl 97 13 in in IN cord-328352-l1q4uvxl 97 14 patients patient NNS cord-328352-l1q4uvxl 97 15 who who WP cord-328352-l1q4uvxl 97 16 have have VBP cord-328352-l1q4uvxl 97 17 received receive VBN cord-328352-l1q4uvxl 97 18 MSCs msc NNS cord-328352-l1q4uvxl 97 19 and and CC cord-328352-l1q4uvxl 97 20 their -PRON- PRP$ cord-328352-l1q4uvxl 97 21 exosomes exosome NNS cord-328352-l1q4uvxl 97 22 31 31 CD cord-328352-l1q4uvxl 97 23 , , , cord-328352-l1q4uvxl 97 24 32 32 CD cord-328352-l1q4uvxl 97 25 . . . cord-328352-l1q4uvxl 98 1 Together together RB cord-328352-l1q4uvxl 98 2 with with IN cord-328352-l1q4uvxl 98 3 convalescent convalescent JJ cord-328352-l1q4uvxl 98 4 plasma plasma NN cord-328352-l1q4uvxl 98 5 and and CC cord-328352-l1q4uvxl 98 6 IG IG NNP cord-328352-l1q4uvxl 98 7 treatments treatment NNS cord-328352-l1q4uvxl 98 8 , , , cord-328352-l1q4uvxl 98 9 stem stem NN cord-328352-l1q4uvxl 98 10 cell cell NN cord-328352-l1q4uvxl 98 11 therapies therapy NNS cord-328352-l1q4uvxl 98 12 may may MD cord-328352-l1q4uvxl 98 13 offer offer VB cord-328352-l1q4uvxl 98 14 an an DT cord-328352-l1q4uvxl 98 15 innovative innovative JJ cord-328352-l1q4uvxl 98 16 approach approach NN cord-328352-l1q4uvxl 98 17 in in IN cord-328352-l1q4uvxl 98 18 fostering foster VBG cord-328352-l1q4uvxl 98 19 immunomodulatory immunomodulatory JJ cord-328352-l1q4uvxl 98 20 regulation regulation NN cord-328352-l1q4uvxl 98 21 of of IN cord-328352-l1q4uvxl 98 22 COVID-19 COVID-19 NNP cord-328352-l1q4uvxl 98 23 . . . cord-328352-l1q4uvxl 99 1 Moreover moreover RB cord-328352-l1q4uvxl 99 2 , , , cord-328352-l1q4uvxl 99 3 although although IN cord-328352-l1q4uvxl 99 4 the the DT cord-328352-l1q4uvxl 99 5 lung lung NN cord-328352-l1q4uvxl 99 6 stands stand VBZ cord-328352-l1q4uvxl 99 7 as as IN cord-328352-l1q4uvxl 99 8 the the DT cord-328352-l1q4uvxl 99 9 main main JJ cord-328352-l1q4uvxl 99 10 pathological pathological JJ cord-328352-l1q4uvxl 99 11 organ organ NN cord-328352-l1q4uvxl 99 12 in in IN cord-328352-l1q4uvxl 99 13 COVID-19 COVID-19 NNP cord-328352-l1q4uvxl 99 14 , , , cord-328352-l1q4uvxl 99 15 recent recent JJ cord-328352-l1q4uvxl 99 16 studies study NNS cord-328352-l1q4uvxl 99 17 have have VBP cord-328352-l1q4uvxl 99 18 implicated implicate VBN cord-328352-l1q4uvxl 99 19 extra extra JJ cord-328352-l1q4uvxl 99 20 - - JJ cord-328352-l1q4uvxl 99 21 lung lung NN cord-328352-l1q4uvxl 99 22 organs organ NNS cord-328352-l1q4uvxl 99 23 , , , cord-328352-l1q4uvxl 99 24 including include VBG cord-328352-l1q4uvxl 99 25 the the DT cord-328352-l1q4uvxl 99 26 heart heart NN cord-328352-l1q4uvxl 99 27 and and CC cord-328352-l1q4uvxl 99 28 the the DT cord-328352-l1q4uvxl 99 29 brain brain NN cord-328352-l1q4uvxl 99 30 , , , cord-328352-l1q4uvxl 99 31 as as RB cord-328352-l1q4uvxl 99 32 well well RB cord-328352-l1q4uvxl 99 33 as as IN cord-328352-l1q4uvxl 99 34 the the DT cord-328352-l1q4uvxl 99 35 gut gut NN cord-328352-l1q4uvxl 99 36 , , , cord-328352-l1q4uvxl 99 37 suggesting suggest VBG cord-328352-l1q4uvxl 99 38 that that IN cord-328352-l1q4uvxl 99 39 targeting target VBG cord-328352-l1q4uvxl 99 40 these these DT cord-328352-l1q4uvxl 99 41 organs organ NNS cord-328352-l1q4uvxl 99 42 may may MD cord-328352-l1q4uvxl 99 43 prove prove VB cord-328352-l1q4uvxl 99 44 beneficial beneficial JJ cord-328352-l1q4uvxl 99 45 in in IN cord-328352-l1q4uvxl 99 46 treating treat VBG cord-328352-l1q4uvxl 99 47 the the DT cord-328352-l1q4uvxl 99 48 disease disease NN cord-328352-l1q4uvxl 99 49 . . . cord-328352-l1q4uvxl 100 1 Indeed indeed RB cord-328352-l1q4uvxl 100 2 , , , cord-328352-l1q4uvxl 100 3 combining combine VBG cord-328352-l1q4uvxl 100 4 the the DT cord-328352-l1q4uvxl 100 5 envisioned envision VBN cord-328352-l1q4uvxl 100 6 vaccines vaccine NNS cord-328352-l1q4uvxl 100 7 and and CC cord-328352-l1q4uvxl 100 8 immunomodulatory immunomodulatory JJ cord-328352-l1q4uvxl 100 9 treatments treatment NNS cord-328352-l1q4uvxl 100 10 with with IN cord-328352-l1q4uvxl 100 11 novel novel JJ cord-328352-l1q4uvxl 100 12 strategies strategy NNS cord-328352-l1q4uvxl 100 13 , , , cord-328352-l1q4uvxl 100 14 such such JJ cord-328352-l1q4uvxl 100 15 as as IN cord-328352-l1q4uvxl 100 16 altering alter VBG cord-328352-l1q4uvxl 100 17 the the DT cord-328352-l1q4uvxl 100 18 gut gut NN cord-328352-l1q4uvxl 100 19 microbiome microbiome NN cord-328352-l1q4uvxl 100 20 37 37 CD cord-328352-l1q4uvxl 100 21 - - SYM cord-328352-l1q4uvxl 100 22 41 41 CD cord-328352-l1q4uvxl 100 23 , , , cord-328352-l1q4uvxl 100 24 will will MD cord-328352-l1q4uvxl 100 25 likely likely RB cord-328352-l1q4uvxl 100 26 enhance enhance VB cord-328352-l1q4uvxl 100 27 the the DT cord-328352-l1q4uvxl 100 28 overall overall JJ cord-328352-l1q4uvxl 100 29 prognosis prognosis NN cord-328352-l1q4uvxl 100 30 of of IN cord-328352-l1q4uvxl 100 31 COVID-19 COVID-19 NNP cord-328352-l1q4uvxl 100 32 . . . cord-328352-l1q4uvxl 101 1 Science science NN cord-328352-l1q4uvxl 101 2 and and CC cord-328352-l1q4uvxl 101 3 medicine medicine NN cord-328352-l1q4uvxl 101 4 may may MD cord-328352-l1q4uvxl 101 5 take take VB cord-328352-l1q4uvxl 101 6 time time NN cord-328352-l1q4uvxl 101 7 to to TO cord-328352-l1q4uvxl 101 8 advance advance VB cord-328352-l1q4uvxl 101 9 a a DT cord-328352-l1q4uvxl 101 10 vaccine vaccine NN cord-328352-l1q4uvxl 101 11 , , , cord-328352-l1q4uvxl 101 12 antiviral antiviral JJ cord-328352-l1q4uvxl 101 13 drug drug NN cord-328352-l1q4uvxl 101 14 , , , cord-328352-l1q4uvxl 101 15 convalescent convalescent JJ cord-328352-l1q4uvxl 101 16 plasma plasma NN cord-328352-l1q4uvxl 101 17 treatment treatment NN cord-328352-l1q4uvxl 101 18 , , , cord-328352-l1q4uvxl 101 19 and and CC cord-328352-l1q4uvxl 101 20 IG ig NN cord-328352-l1q4uvxl 101 21 and and CC cord-328352-l1q4uvxl 101 22 stem stem VB cord-328352-l1q4uvxl 101 23 cell cell NN cord-328352-l1q4uvxl 101 24 therapies therapy NNS cord-328352-l1q4uvxl 101 25 to to IN cord-328352-l1q4uvxl 101 26 the the DT cord-328352-l1q4uvxl 101 27 clinic clinic NN cord-328352-l1q4uvxl 101 28 . . . cord-328352-l1q4uvxl 102 1 Mortality mortality NN cord-328352-l1q4uvxl 102 2 rate rate NN cord-328352-l1q4uvxl 102 3 ranges range NNS cord-328352-l1q4uvxl 102 4 from from IN cord-328352-l1q4uvxl 102 5 0.1 0.1 CD cord-328352-l1q4uvxl 102 6 % % NN cord-328352-l1q4uvxl 102 7 to to IN cord-328352-l1q4uvxl 102 8 as as RB cord-328352-l1q4uvxl 102 9 high high JJ cord-328352-l1q4uvxl 102 10 as as IN cord-328352-l1q4uvxl 102 11 10 10 CD cord-328352-l1q4uvxl 102 12 % % NN cord-328352-l1q4uvxl 102 13 , , , cord-328352-l1q4uvxl 102 14 with with IN cord-328352-l1q4uvxl 102 15 the the DT cord-328352-l1q4uvxl 102 16 elderly elderly JJ cord-328352-l1q4uvxl 102 17 ( ( -LRB- cord-328352-l1q4uvxl 102 18 > > NFP cord-328352-l1q4uvxl 102 19 65 65 CD cord-328352-l1q4uvxl 102 20 years year NNS cord-328352-l1q4uvxl 102 21 of of IN cord-328352-l1q4uvxl 102 22 age age NN cord-328352-l1q4uvxl 102 23 ) ) -RRB- cord-328352-l1q4uvxl 102 24 and and CC cord-328352-l1q4uvxl 102 25 those those DT cord-328352-l1q4uvxl 102 26 with with IN cord-328352-l1q4uvxl 102 27 preexisting preexisting JJ cord-328352-l1q4uvxl 102 28 immune immune NN cord-328352-l1q4uvxl 102 29 - - HYPH cord-328352-l1q4uvxl 102 30 related relate VBN cord-328352-l1q4uvxl 102 31 and and CC cord-328352-l1q4uvxl 102 32 inflammatory inflammatory JJ cord-328352-l1q4uvxl 102 33 diseases disease NNS cord-328352-l1q4uvxl 102 34 ( ( -LRB- cord-328352-l1q4uvxl 102 35 hypertension hypertension NN cord-328352-l1q4uvxl 102 36 , , , cord-328352-l1q4uvxl 102 37 diabetes diabetes NN cord-328352-l1q4uvxl 102 38 , , , cord-328352-l1q4uvxl 102 39 heart heart NN cord-328352-l1q4uvxl 102 40 diseases disease NNS cord-328352-l1q4uvxl 102 41 ) ) -RRB- cord-328352-l1q4uvxl 102 42 , , , cord-328352-l1q4uvxl 102 43 showing show VBG cord-328352-l1q4uvxl 102 44 higher high JJR cord-328352-l1q4uvxl 102 45 incidence incidence NN cord-328352-l1q4uvxl 102 46 of of IN cord-328352-l1q4uvxl 102 47 mortality mortality NN cord-328352-l1q4uvxl 102 48 [ [ -LRB- cord-328352-l1q4uvxl 102 49 42 42 CD cord-328352-l1q4uvxl 102 50 ] ] -RRB- cord-328352-l1q4uvxl 102 51 [ [ -LRB- cord-328352-l1q4uvxl 102 52 43 43 CD cord-328352-l1q4uvxl 102 53 ] ] -RRB- cord-328352-l1q4uvxl 102 54 [ [ -LRB- cord-328352-l1q4uvxl 102 55 44 44 CD cord-328352-l1q4uvxl 102 56 ] ] -RRB- cord-328352-l1q4uvxl 102 57 . . . cord-328352-l1q4uvxl 103 1 Given give VBN cord-328352-l1q4uvxl 103 2 the the DT cord-328352-l1q4uvxl 103 3 morbidity morbidity NN cord-328352-l1q4uvxl 103 4 not not RB cord-328352-l1q4uvxl 103 5 only only RB cord-328352-l1q4uvxl 103 6 in in IN cord-328352-l1q4uvxl 103 7 the the DT cord-328352-l1q4uvxl 103 8 acute acute JJ cord-328352-l1q4uvxl 103 9 stage stage NN cord-328352-l1q4uvxl 103 10 , , , cord-328352-l1q4uvxl 103 11 but but CC cord-328352-l1q4uvxl 103 12 the the DT cord-328352-l1q4uvxl 103 13 realization realization NN cord-328352-l1q4uvxl 103 14 of of IN cord-328352-l1q4uvxl 103 15 equally equally RB cord-328352-l1q4uvxl 103 16 devastating devastating JJ cord-328352-l1q4uvxl 103 17 long long JJ cord-328352-l1q4uvxl 103 18 - - HYPH cord-328352-l1q4uvxl 103 19 term term NN cord-328352-l1q4uvxl 103 20 effects effect NNS cord-328352-l1q4uvxl 103 21 , , , cord-328352-l1q4uvxl 103 22 including include VBG cord-328352-l1q4uvxl 103 23 cardiovascular cardiovascular JJ cord-328352-l1q4uvxl 103 24 and and CC cord-328352-l1q4uvxl 103 25 cerebrovascular cerebrovascular JJ cord-328352-l1q4uvxl 103 26 consequences consequence NNS cord-328352-l1q4uvxl 103 27 [ [ -LRB- cord-328352-l1q4uvxl 103 28 45 45 CD cord-328352-l1q4uvxl 103 29 ] ] -RRB- cord-328352-l1q4uvxl 103 30 [ [ -LRB- cord-328352-l1q4uvxl 103 31 46 46 CD cord-328352-l1q4uvxl 103 32 ] ] -RRB- cord-328352-l1q4uvxl 103 33 [ [ -LRB- cord-328352-l1q4uvxl 103 34 47 47 CD cord-328352-l1q4uvxl 103 35 ] ] -RRB- cord-328352-l1q4uvxl 103 36 [ [ -LRB- cord-328352-l1q4uvxl 103 37 48 48 CD cord-328352-l1q4uvxl 103 38 ] ] -RRB- cord-328352-l1q4uvxl 103 39 [ [ -LRB- cord-328352-l1q4uvxl 103 40 49 49 CD cord-328352-l1q4uvxl 103 41 ] ] -RRB- cord-328352-l1q4uvxl 103 42 , , , cord-328352-l1q4uvxl 103 43 warrants warrant VBZ cord-328352-l1q4uvxl 103 44 immediate immediate JJ cord-328352-l1q4uvxl 103 45 action action NN cord-328352-l1q4uvxl 103 46 to to IN cord-328352-l1q4uvxl 103 47 at at IN cord-328352-l1q4uvxl 103 48 least least JJS cord-328352-l1q4uvxl 103 49 lessen lessen VB cord-328352-l1q4uvxl 103 50 the the DT cord-328352-l1q4uvxl 103 51 spread spread NN cord-328352-l1q4uvxl 103 52 of of IN cord-328352-l1q4uvxl 103 53 the the DT cord-328352-l1q4uvxl 103 54 virus virus NN cord-328352-l1q4uvxl 103 55 . . . cord-328352-l1q4uvxl 104 1 Without without IN cord-328352-l1q4uvxl 104 2 access access NN cord-328352-l1q4uvxl 104 3 to to IN cord-328352-l1q4uvxl 104 4 the the DT cord-328352-l1q4uvxl 104 5 vaccine vaccine NN cord-328352-l1q4uvxl 104 6 and and CC cord-328352-l1q4uvxl 104 7 other other JJ cord-328352-l1q4uvxl 104 8 proven prove VBN cord-328352-l1q4uvxl 104 9 therapies therapy NNS cord-328352-l1q4uvxl 104 10 , , , cord-328352-l1q4uvxl 104 11 just just RB cord-328352-l1q4uvxl 104 12 like like IN cord-328352-l1q4uvxl 104 13 in in IN cord-328352-l1q4uvxl 104 14 1918 1918 CD cord-328352-l1q4uvxl 104 15 Spanish spanish JJ cord-328352-l1q4uvxl 104 16 flu flu NN cord-328352-l1q4uvxl 104 17 era era NN cord-328352-l1q4uvxl 104 18 , , , cord-328352-l1q4uvxl 104 19 the the DT cord-328352-l1q4uvxl 104 20 best good JJS cord-328352-l1q4uvxl 104 21 course course NN cord-328352-l1q4uvxl 104 22 of of IN cord-328352-l1q4uvxl 104 23 action action NN cord-328352-l1q4uvxl 104 24 for for IN cord-328352-l1q4uvxl 104 25 the the DT cord-328352-l1q4uvxl 104 26 meantime meantime NN cord-328352-l1q4uvxl 104 27 is be VBZ cord-328352-l1q4uvxl 104 28 practicing practice VBG cord-328352-l1q4uvxl 104 29 social social JJ cord-328352-l1q4uvxl 104 30 distancing distancing NN cord-328352-l1q4uvxl 104 31 and and CC cord-328352-l1q4uvxl 104 32 good good JJ cord-328352-l1q4uvxl 104 33 hygiene hygiene NN cord-328352-l1q4uvxl 104 34 , , , cord-328352-l1q4uvxl 104 35 which which WDT cord-328352-l1q4uvxl 104 36 represents represent VBZ cord-328352-l1q4uvxl 104 37 a a DT cord-328352-l1q4uvxl 104 38 logical logical JJ cord-328352-l1q4uvxl 104 39 strategy strategy NN cord-328352-l1q4uvxl 104 40 to to TO cord-328352-l1q4uvxl 104 41 curve curve VB cord-328352-l1q4uvxl 104 42 the the DT cord-328352-l1q4uvxl 104 43 course course NN cord-328352-l1q4uvxl 104 44 and and CC cord-328352-l1q4uvxl 104 45 to to TO cord-328352-l1q4uvxl 104 46 address address VB cord-328352-l1q4uvxl 104 47 the the DT cord-328352-l1q4uvxl 104 48 disillusioned disillusioned JJ cord-328352-l1q4uvxl 104 49 comfort comfort NN cord-328352-l1q4uvxl 104 50 of of IN cord-328352-l1q4uvxl 104 51 COVID-19 COVID-19 NNP cord-328352-l1q4uvxl 104 52 . . . cord-328352-l1q4uvxl 105 1 The the DT cord-328352-l1q4uvxl 105 2 author(s author(s NNP cord-328352-l1q4uvxl 105 3 ) ) -RRB- cord-328352-l1q4uvxl 105 4 declared declare VBD cord-328352-l1q4uvxl 105 5 no no DT cord-328352-l1q4uvxl 105 6 potential potential JJ cord-328352-l1q4uvxl 105 7 conflicts conflict NNS cord-328352-l1q4uvxl 105 8 of of IN cord-328352-l1q4uvxl 105 9 interest interest NN cord-328352-l1q4uvxl 105 10 with with IN cord-328352-l1q4uvxl 105 11 respect respect NN cord-328352-l1q4uvxl 105 12 to to IN cord-328352-l1q4uvxl 105 13 the the DT cord-328352-l1q4uvxl 105 14 research research NN cord-328352-l1q4uvxl 105 15 , , , cord-328352-l1q4uvxl 105 16 authorship authorship NN cord-328352-l1q4uvxl 105 17 , , , cord-328352-l1q4uvxl 105 18 and/or and/or CC cord-328352-l1q4uvxl 105 19 publication publication NN cord-328352-l1q4uvxl 105 20 of of IN cord-328352-l1q4uvxl 105 21 this this DT cord-328352-l1q4uvxl 105 22 article article NN cord-328352-l1q4uvxl 105 23 . . . cord-328352-l1q4uvxl 106 1 The the DT cord-328352-l1q4uvxl 106 2 author(s author(s NNP cord-328352-l1q4uvxl 106 3 ) ) -RRB- cord-328352-l1q4uvxl 106 4 received receive VBD cord-328352-l1q4uvxl 106 5 no no DT cord-328352-l1q4uvxl 106 6 financial financial JJ cord-328352-l1q4uvxl 106 7 support support NN cord-328352-l1q4uvxl 106 8 for for IN cord-328352-l1q4uvxl 106 9 the the DT cord-328352-l1q4uvxl 106 10 research research NN cord-328352-l1q4uvxl 106 11 , , , cord-328352-l1q4uvxl 106 12 authorship authorship NN cord-328352-l1q4uvxl 106 13 , , , cord-328352-l1q4uvxl 106 14 and/or and/or CC cord-328352-l1q4uvxl 106 15 publication publication NN cord-328352-l1q4uvxl 106 16 of of IN cord-328352-l1q4uvxl 106 17 this this DT cord-328352-l1q4uvxl 106 18 article article NN cord-328352-l1q4uvxl 106 19 . . . cord-328352-l1q4uvxl 107 1 Mia Mia NNP cord-328352-l1q4uvxl 107 2 C. C. NNP cord-328352-l1q4uvxl 107 3 Borlongan Borlongan NNP cord-328352-l1q4uvxl 107 4 https://orcid.org/0000-0003-3223-8374 https://orcid.org/0000-0003-3223-8374 CD cord-328352-l1q4uvxl 107 5 Lung lung NN cord-328352-l1q4uvxl 107 6 cancer cancer NN cord-328352-l1q4uvxl 107 7 mortality mortality NN cord-328352-l1q4uvxl 107 8 associated associate VBN cord-328352-l1q4uvxl 107 9 with with IN cord-328352-l1q4uvxl 107 10 smoking smoking NN cord-328352-l1q4uvxl 107 11 and and CC cord-328352-l1q4uvxl 107 12 smoking smoking NN cord-328352-l1q4uvxl 107 13 cessation cessation NN cord-328352-l1q4uvxl 107 14 among among IN cord-328352-l1q4uvxl 107 15 people people NNS cord-328352-l1q4uvxl 107 16 living live VBG cord-328352-l1q4uvxl 107 17 with with IN cord-328352-l1q4uvxl 107 18 HIV HIV NNP cord-328352-l1q4uvxl 107 19 in in IN cord-328352-l1q4uvxl 107 20 the the DT cord-328352-l1q4uvxl 107 21 United United NNP cord-328352-l1q4uvxl 107 22 States States NNP cord-328352-l1q4uvxl 107 23 . . . cord-328352-l1q4uvxl 108 1 Version version NN cord-328352-l1q4uvxl 108 2 2 2 CD cord-328352-l1q4uvxl 108 3 Gender gender NN cord-328352-l1q4uvxl 108 4 - - HYPH cord-328352-l1q4uvxl 108 5 related relate VBN cord-328352-l1q4uvxl 108 6 differences difference NNS cord-328352-l1q4uvxl 108 7 in in IN cord-328352-l1q4uvxl 108 8 the the DT cord-328352-l1q4uvxl 108 9 characteristics characteristic NNS cord-328352-l1q4uvxl 108 10 of of IN cord-328352-l1q4uvxl 108 11 problem problem NN cord-328352-l1q4uvxl 108 12 gamblers gambler NNS cord-328352-l1q4uvxl 108 13 using use VBG cord-328352-l1q4uvxl 108 14 a a DT cord-328352-l1q4uvxl 108 15 gambling gambling NN cord-328352-l1q4uvxl 108 16 helpline helpline NN cord-328352-l1q4uvxl 108 17 Traffic traffic NN cord-328352-l1q4uvxl 108 18 accident accident NN cord-328352-l1q4uvxl 108 19 statistics statistic NNS cord-328352-l1q4uvxl 108 20 and and CC cord-328352-l1q4uvxl 108 21 risk risk NN cord-328352-l1q4uvxl 108 22 perceptions perception NNS cord-328352-l1q4uvxl 108 23 in in IN cord-328352-l1q4uvxl 108 24 Japan Japan NNP cord-328352-l1q4uvxl 108 25 and and CC cord-328352-l1q4uvxl 108 26 the the DT cord-328352-l1q4uvxl 108 27 United United NNP cord-328352-l1q4uvxl 108 28 States States NNP cord-328352-l1q4uvxl 108 29 Maps Maps NNPS cord-328352-l1q4uvxl 108 30 & & CC cord-328352-l1q4uvxl 108 31 trends- trends- NNP cord-328352-l1q4uvxl 109 1 Tracking track VBG cord-328352-l1q4uvxl 109 2 global global JJ cord-328352-l1q4uvxl 109 3 cases case NNS cord-328352-l1q4uvxl 109 4 and and CC cord-328352-l1q4uvxl 109 5 tracking track VBG cord-328352-l1q4uvxl 109 6 critical critical JJ cord-328352-l1q4uvxl 109 7 data datum NNS cord-328352-l1q4uvxl 109 8 Covid-19 covid-19 NN cord-328352-l1q4uvxl 109 9 -navigating -navigate VBG cord-328352-l1q4uvxl 109 10 the the DT cord-328352-l1q4uvxl 109 11 uncharted uncharted JJ cord-328352-l1q4uvxl 109 12 Airborne airborne JJ cord-328352-l1q4uvxl 109 13 transmission transmission NN cord-328352-l1q4uvxl 109 14 of of IN cord-328352-l1q4uvxl 109 15 severe severe JJ cord-328352-l1q4uvxl 109 16 acute acute JJ cord-328352-l1q4uvxl 109 17 respiratory respiratory JJ cord-328352-l1q4uvxl 109 18 syndrome syndrome NN cord-328352-l1q4uvxl 109 19 coronavirus-2 coronavirus-2 NN cord-328352-l1q4uvxl 109 20 to to IN cord-328352-l1q4uvxl 109 21 healthcare healthcare NN cord-328352-l1q4uvxl 109 22 workers worker NNS cord-328352-l1q4uvxl 109 23 : : : cord-328352-l1q4uvxl 109 24 a a DT cord-328352-l1q4uvxl 109 25 narrative narrative NN cord-328352-l1q4uvxl 109 26 review review NN cord-328352-l1q4uvxl 109 27 Applying apply VBG cord-328352-l1q4uvxl 109 28 principles principle NNS cord-328352-l1q4uvxl 109 29 of of IN cord-328352-l1q4uvxl 109 30 behaviour behaviour NN cord-328352-l1q4uvxl 109 31 change change NN cord-328352-l1q4uvxl 109 32 to to TO cord-328352-l1q4uvxl 109 33 reduce reduce VB cord-328352-l1q4uvxl 109 34 SARS SARS NNP cord-328352-l1q4uvxl 109 35 - - HYPH cord-328352-l1q4uvxl 109 36 CoV-2 CoV-2 NNP cord-328352-l1q4uvxl 109 37 transmission transmission NN cord-328352-l1q4uvxl 109 38 Respiratory respiratory JJ cord-328352-l1q4uvxl 109 39 virus virus NN cord-328352-l1q4uvxl 109 40 shedding shed VBG cord-328352-l1q4uvxl 109 41 in in IN cord-328352-l1q4uvxl 109 42 exhaled exhaled JJ cord-328352-l1q4uvxl 109 43 breath breath NN cord-328352-l1q4uvxl 109 44 and and CC cord-328352-l1q4uvxl 109 45 efficacy efficacy NN cord-328352-l1q4uvxl 109 46 of of IN cord-328352-l1q4uvxl 109 47 face face NN cord-328352-l1q4uvxl 109 48 masks mask NNS cord-328352-l1q4uvxl 110 1 The the DT cord-328352-l1q4uvxl 110 2 deadly deadly JJ cord-328352-l1q4uvxl 110 3 coronaviruses coronaviruse NNS cord-328352-l1q4uvxl 110 4 : : : cord-328352-l1q4uvxl 110 5 the the DT cord-328352-l1q4uvxl 110 6 2003 2003 CD cord-328352-l1q4uvxl 110 7 SARS SARS NNP cord-328352-l1q4uvxl 110 8 pandemic pandemic NN cord-328352-l1q4uvxl 110 9 and and CC cord-328352-l1q4uvxl 110 10 the the DT cord-328352-l1q4uvxl 110 11 2020 2020 CD cord-328352-l1q4uvxl 110 12 novel novel JJ cord-328352-l1q4uvxl 110 13 coronavirus coronavirus NN cord-328352-l1q4uvxl 110 14 epidemic epidemic NN cord-328352-l1q4uvxl 110 15 in in IN cord-328352-l1q4uvxl 110 16 China China NNP cord-328352-l1q4uvxl 110 17 First first JJ cord-328352-l1q4uvxl 110 18 cases case NNS cord-328352-l1q4uvxl 110 19 of of IN cord-328352-l1q4uvxl 110 20 coronavirus coronavirus NN cord-328352-l1q4uvxl 110 21 disease disease NN cord-328352-l1q4uvxl 110 22 2019 2019 CD cord-328352-l1q4uvxl 110 23 ( ( -LRB- cord-328352-l1q4uvxl 110 24 COVID-19 COVID-19 NNP cord-328352-l1q4uvxl 110 25 ) ) -RRB- cord-328352-l1q4uvxl 110 26 in in IN cord-328352-l1q4uvxl 110 27 the the DT cord-328352-l1q4uvxl 110 28 WHO WHO NNP cord-328352-l1q4uvxl 110 29 European European NNP cord-328352-l1q4uvxl 110 30 Region Region NNP cord-328352-l1q4uvxl 110 31 SARS SARS NNP cord-328352-l1q4uvxl 111 1 -CoV-2 -CoV-2 : cord-328352-l1q4uvxl 111 2 : : : cord-328352-l1q4uvxl 111 3 reasons reason NNS cord-328352-l1q4uvxl 111 4 of of IN cord-328352-l1q4uvxl 111 5 epidemiology epidemiology NN cord-328352-l1q4uvxl 111 6 of of IN cord-328352-l1q4uvxl 111 7 severe severe JJ cord-328352-l1q4uvxl 111 8 ill ill JJ cord-328352-l1q4uvxl 111 9 disease disease NN cord-328352-l1q4uvxl 111 10 cases case NNS cord-328352-l1q4uvxl 111 11 and and CC cord-328352-l1q4uvxl 111 12 therapeutic therapeutic JJ cord-328352-l1q4uvxl 111 13 approach approach NN cord-328352-l1q4uvxl 111 14 using use VBG cord-328352-l1q4uvxl 111 15 trivalent trivalent JJ cord-328352-l1q4uvxl 111 16 vaccine vaccine NN cord-328352-l1q4uvxl 111 17 ( ( -LRB- cord-328352-l1q4uvxl 111 18 tetanus tetanus NN cord-328352-l1q4uvxl 111 19 , , , cord-328352-l1q4uvxl 111 20 diphtheria diphtheria NN cord-328352-l1q4uvxl 111 21 and and CC cord-328352-l1q4uvxl 111 22 Bordetella Bordetella NNP cord-328352-l1q4uvxl 111 23 pertussis pertussis NN cord-328352-l1q4uvxl 111 24 ) ) -RRB- cord-328352-l1q4uvxl 111 25 . . . cord-328352-l1q4uvxl 112 1 Med Med NNP cord-328352-l1q4uvxl 112 2 Hypotheses Hypotheses NNPS cord-328352-l1q4uvxl 112 3 Coronavirus Coronavirus NNP cord-328352-l1q4uvxl 112 4 disease disease NN cord-328352-l1q4uvxl 112 5 2019 2019 CD cord-328352-l1q4uvxl 112 6 in in IN cord-328352-l1q4uvxl 112 7 geriatrics geriatric NNS cord-328352-l1q4uvxl 112 8 and and CC cord-328352-l1q4uvxl 112 9 long long JJ cord-328352-l1q4uvxl 112 10 - - HYPH cord-328352-l1q4uvxl 112 11 term term NN cord-328352-l1q4uvxl 112 12 care care NN cord-328352-l1q4uvxl 112 13 : : : cord-328352-l1q4uvxl 112 14 the the DT cord-328352-l1q4uvxl 112 15 abcds abcds NNP cord-328352-l1q4uvxl 112 16 of of IN cord-328352-l1q4uvxl 112 17 COVID-19 COVID-19 NNP cord-328352-l1q4uvxl 112 18 Pandemics Pandemics NNPS cord-328352-l1q4uvxl 112 19 : : : cord-328352-l1q4uvxl 113 1 avoiding avoid VBG cord-328352-l1q4uvxl 113 2 the the DT cord-328352-l1q4uvxl 113 3 mistakes mistake NNS cord-328352-l1q4uvxl 113 4 of of IN cord-328352-l1q4uvxl 113 5 1918 1918 CD cord-328352-l1q4uvxl 113 6 A a DT cord-328352-l1q4uvxl 113 7 year year NN cord-328352-l1q4uvxl 113 8 of of IN cord-328352-l1q4uvxl 113 9 terror terror NN cord-328352-l1q4uvxl 113 10 and and CC cord-328352-l1q4uvxl 113 11 a a DT cord-328352-l1q4uvxl 113 12 century century NN cord-328352-l1q4uvxl 113 13 of of IN cord-328352-l1q4uvxl 113 14 reflection reflection NN cord-328352-l1q4uvxl 113 15 : : : cord-328352-l1q4uvxl 113 16 perspectives perspective NNS cord-328352-l1q4uvxl 113 17 on on IN cord-328352-l1q4uvxl 113 18 the the DT cord-328352-l1q4uvxl 113 19 great great JJ cord-328352-l1q4uvxl 113 20 influenza influenza NN cord-328352-l1q4uvxl 113 21 pandemic pandemic NN cord-328352-l1q4uvxl 113 22 of of IN cord-328352-l1q4uvxl 113 23 1918 1918 CD cord-328352-l1q4uvxl 113 24 - - SYM cord-328352-l1q4uvxl 113 25 1919 1919 CD cord-328352-l1q4uvxl 113 26 Deployment Deployment NNP cord-328352-l1q4uvxl 113 27 of of IN cord-328352-l1q4uvxl 113 28 convalescent convalescent JJ cord-328352-l1q4uvxl 113 29 plasma plasma NN cord-328352-l1q4uvxl 113 30 for for IN cord-328352-l1q4uvxl 113 31 the the DT cord-328352-l1q4uvxl 113 32 prevention prevention NN cord-328352-l1q4uvxl 113 33 and and CC cord-328352-l1q4uvxl 113 34 treatment treatment NN cord-328352-l1q4uvxl 113 35 of of IN cord-328352-l1q4uvxl 113 36 COVID-19 COVID-19 NNP cord-328352-l1q4uvxl 113 37 Children Children NNPS cord-328352-l1q4uvxl 113 38 and and CC cord-328352-l1q4uvxl 113 39 encephalitis encephalitis RB cord-328352-l1q4uvxl 113 40 lethargica lethargica NNP cord-328352-l1q4uvxl 113 41 : : : cord-328352-l1q4uvxl 113 42 a a DT cord-328352-l1q4uvxl 113 43 historical historical JJ cord-328352-l1q4uvxl 113 44 review review NN cord-328352-l1q4uvxl 113 45 Influenza Influenza NNP cord-328352-l1q4uvxl 113 46 virus virus NN cord-328352-l1q4uvxl 113 47 and and CC cord-328352-l1q4uvxl 113 48 neurological neurological JJ cord-328352-l1q4uvxl 113 49 diseases disease NNS cord-328352-l1q4uvxl 114 1 The the DT cord-328352-l1q4uvxl 114 2 relationship relationship NN cord-328352-l1q4uvxl 114 3 between between IN cord-328352-l1q4uvxl 114 4 encephalitis encephalitis NNP cord-328352-l1q4uvxl 114 5 lethargica lethargica NNP cord-328352-l1q4uvxl 114 6 and and CC cord-328352-l1q4uvxl 114 7 influenza influenza NN cord-328352-l1q4uvxl 114 8 : : : cord-328352-l1q4uvxl 114 9 a a DT cord-328352-l1q4uvxl 114 10 critical critical JJ cord-328352-l1q4uvxl 114 11 analysis analysis NN cord-328352-l1q4uvxl 114 12 Plasma plasma NN cord-328352-l1q4uvxl 114 13 therapy therapy NN cord-328352-l1q4uvxl 114 14 against against IN cord-328352-l1q4uvxl 114 15 infectious infectious JJ cord-328352-l1q4uvxl 114 16 pathogens pathogen NNS cord-328352-l1q4uvxl 114 17 , , , cord-328352-l1q4uvxl 114 18 as as IN cord-328352-l1q4uvxl 114 19 of of IN cord-328352-l1q4uvxl 114 20 yesterday yesterday NN cord-328352-l1q4uvxl 114 21 , , , cord-328352-l1q4uvxl 114 22 today today NN cord-328352-l1q4uvxl 114 23 and and CC cord-328352-l1q4uvxl 114 24 tomorrow tomorrow NN cord-328352-l1q4uvxl 114 25 Metaanalysis metaanalysis NN cord-328352-l1q4uvxl 114 26 : : : cord-328352-l1q4uvxl 114 27 convalescent convalescent JJ cord-328352-l1q4uvxl 114 28 blood blood NN cord-328352-l1q4uvxl 114 29 products product NNS cord-328352-l1q4uvxl 114 30 for for IN cord-328352-l1q4uvxl 114 31 Spanish spanish JJ cord-328352-l1q4uvxl 114 32 influenza influenza NN cord-328352-l1q4uvxl 114 33 pneumonia pneumonia NN cord-328352-l1q4uvxl 114 34 : : : cord-328352-l1q4uvxl 114 35 a a DT cord-328352-l1q4uvxl 114 36 future future JJ cord-328352-l1q4uvxl 114 37 H5N1 H5N1 NNP cord-328352-l1q4uvxl 114 38 treatment treatment NN cord-328352-l1q4uvxl 114 39 ? ? . cord-328352-l1q4uvxl 115 1 Convalescent convalescent JJ cord-328352-l1q4uvxl 115 2 plasma plasma NN cord-328352-l1q4uvxl 115 3 study study NN cord-328352-l1q4uvxl 115 4 group group NN cord-328352-l1q4uvxl 115 5 . . . cord-328352-l1q4uvxl 116 1 The the DT cord-328352-l1q4uvxl 116 2 effectiveness effectiveness NN cord-328352-l1q4uvxl 116 3 of of IN cord-328352-l1q4uvxl 116 4 convalescent convalescent JJ cord-328352-l1q4uvxl 116 5 plasma plasma NN cord-328352-l1q4uvxl 116 6 and and CC cord-328352-l1q4uvxl 116 7 hyperimmune hyperimmune NNP cord-328352-l1q4uvxl 116 8 immunoglobulin immunoglobulin NN cord-328352-l1q4uvxl 116 9 for for IN cord-328352-l1q4uvxl 116 10 the the DT cord-328352-l1q4uvxl 116 11 treatment treatment NN cord-328352-l1q4uvxl 116 12 of of IN cord-328352-l1q4uvxl 116 13 severe severe JJ cord-328352-l1q4uvxl 116 14 acute acute JJ cord-328352-l1q4uvxl 116 15 respiratory respiratory JJ cord-328352-l1q4uvxl 116 16 infections infection NNS cord-328352-l1q4uvxl 116 17 of of IN cord-328352-l1q4uvxl 116 18 viral viral JJ cord-328352-l1q4uvxl 116 19 etiology etiology NN cord-328352-l1q4uvxl 116 20 : : : cord-328352-l1q4uvxl 116 21 a a DT cord-328352-l1q4uvxl 116 22 systematic systematic JJ cord-328352-l1q4uvxl 116 23 review review NN cord-328352-l1q4uvxl 116 24 and and CC cord-328352-l1q4uvxl 116 25 exploratory exploratory JJ cord-328352-l1q4uvxl 116 26 metaanalysis metaanalysis NNP cord-328352-l1q4uvxl 116 27 Version Version NNP cord-328352-l1q4uvxl 116 28 2 2 CD cord-328352-l1q4uvxl 116 29 Treatment Treatment NNP cord-328352-l1q4uvxl 116 30 with with IN cord-328352-l1q4uvxl 116 31 convalescent convalescent JJ cord-328352-l1q4uvxl 116 32 plasma plasma NN cord-328352-l1q4uvxl 116 33 for for IN cord-328352-l1q4uvxl 116 34 COVID-19 covid-19 JJ cord-328352-l1q4uvxl 116 35 patients patient NNS cord-328352-l1q4uvxl 116 36 in in IN cord-328352-l1q4uvxl 116 37 Wuhan Wuhan NNP cord-328352-l1q4uvxl 116 38 Effectiveness Effectiveness NNP cord-328352-l1q4uvxl 116 39 of of IN cord-328352-l1q4uvxl 116 40 convalescent convalescent JJ cord-328352-l1q4uvxl 116 41 plasma plasma NN cord-328352-l1q4uvxl 116 42 therapy therapy NN cord-328352-l1q4uvxl 116 43 in in IN cord-328352-l1q4uvxl 116 44 severe severe JJ cord-328352-l1q4uvxl 116 45 COVID-19 COVID-19 NNP cord-328352-l1q4uvxl 116 46 patients patient NNS cord-328352-l1q4uvxl 116 47 Treatment Treatment NNP cord-328352-l1q4uvxl 116 48 of of IN cord-328352-l1q4uvxl 116 49 5 5 CD cord-328352-l1q4uvxl 116 50 critically critically RB cord-328352-l1q4uvxl 116 51 ill ill JJ cord-328352-l1q4uvxl 116 52 patients patient NNS cord-328352-l1q4uvxl 116 53 with with IN cord-328352-l1q4uvxl 116 54 COVID-19 COVID-19 NNP cord-328352-l1q4uvxl 116 55 with with IN cord-328352-l1q4uvxl 116 56 convalescent convalescent JJ cord-328352-l1q4uvxl 116 57 plasma plasma NN cord-328352-l1q4uvxl 116 58 Effect effect NN cord-328352-l1q4uvxl 116 59 of of IN cord-328352-l1q4uvxl 116 60 convalescent convalescent JJ cord-328352-l1q4uvxl 116 61 plasma plasma NN cord-328352-l1q4uvxl 116 62 therapy therapy NN cord-328352-l1q4uvxl 116 63 on on IN cord-328352-l1q4uvxl 116 64 viral viral JJ cord-328352-l1q4uvxl 116 65 shedding shedding NN cord-328352-l1q4uvxl 116 66 and and CC cord-328352-l1q4uvxl 116 67 survival survival NN cord-328352-l1q4uvxl 116 68 in in IN cord-328352-l1q4uvxl 116 69 covid-19 covid-19 CD cord-328352-l1q4uvxl 116 70 patients patient NNS cord-328352-l1q4uvxl 116 71 Use Use NNP cord-328352-l1q4uvxl 116 72 of of IN cord-328352-l1q4uvxl 116 73 Convalescent convalescent JJ cord-328352-l1q4uvxl 116 74 plasma plasma NN cord-328352-l1q4uvxl 116 75 therapy therapy NN cord-328352-l1q4uvxl 116 76 in in IN cord-328352-l1q4uvxl 116 77 two two CD cord-328352-l1q4uvxl 116 78 covid-19 covid-19 CD cord-328352-l1q4uvxl 116 79 patients patient NNS cord-328352-l1q4uvxl 116 80 with with IN cord-328352-l1q4uvxl 116 81 acute acute JJ cord-328352-l1q4uvxl 116 82 respiratory respiratory JJ cord-328352-l1q4uvxl 116 83 distress distress NN cord-328352-l1q4uvxl 116 84 syndrome syndrome NN cord-328352-l1q4uvxl 116 85 in in IN cord-328352-l1q4uvxl 116 86 Korea Korea NNP cord-328352-l1q4uvxl 116 87 Active Active NNP cord-328352-l1q4uvxl 116 88 therapy therapy NN cord-328352-l1q4uvxl 116 89 with with IN cord-328352-l1q4uvxl 116 90 passive passive JJ cord-328352-l1q4uvxl 116 91 immunotherapy immunotherapy NN cord-328352-l1q4uvxl 116 92 may may MD cord-328352-l1q4uvxl 116 93 be be VB cord-328352-l1q4uvxl 116 94 effective effective JJ cord-328352-l1q4uvxl 116 95 in in IN cord-328352-l1q4uvxl 116 96 the the DT cord-328352-l1q4uvxl 116 97 fight fight NN cord-328352-l1q4uvxl 116 98 against against IN cord-328352-l1q4uvxl 116 99 Covid-19 Covid-19 NNP cord-328352-l1q4uvxl 116 100 Convalescent Convalescent NNP cord-328352-l1q4uvxl 116 101 plasma plasma NN cord-328352-l1q4uvxl 116 102 or or CC cord-328352-l1q4uvxl 116 103 hyperimmune hyperimmune NN cord-328352-l1q4uvxl 116 104 immunoglobulin immunoglobulin NN cord-328352-l1q4uvxl 116 105 for for IN cord-328352-l1q4uvxl 116 106 people people NNS cord-328352-l1q4uvxl 116 107 with with IN cord-328352-l1q4uvxl 116 108 COVID-19 COVID-19 NNP cord-328352-l1q4uvxl 116 109 : : : cord-328352-l1q4uvxl 116 110 a a DT cord-328352-l1q4uvxl 116 111 rapid rapid JJ cord-328352-l1q4uvxl 116 112 review review NN cord-328352-l1q4uvxl 116 113 SARS SARS NNP cord-328352-l1q4uvxl 116 114 - - HYPH cord-328352-l1q4uvxl 116 115 CoV-2 CoV-2 NNP cord-328352-l1q4uvxl 116 116 inflammatory inflammatory JJ cord-328352-l1q4uvxl 116 117 syndrome syndrome NN cord-328352-l1q4uvxl 116 118 . . . cord-328352-l1q4uvxl 117 1 Clinical clinical JJ cord-328352-l1q4uvxl 117 2 features feature NNS cord-328352-l1q4uvxl 117 3 and and CC cord-328352-l1q4uvxl 117 4 rationale rationale NN cord-328352-l1q4uvxl 117 5 for for IN cord-328352-l1q4uvxl 117 6 immunological immunological JJ cord-328352-l1q4uvxl 117 7 treatment treatment NN cord-328352-l1q4uvxl 117 8 Expanded expand VBD cord-328352-l1q4uvxl 117 9 umbilical umbilical JJ cord-328352-l1q4uvxl 117 10 cord cord NN cord-328352-l1q4uvxl 117 11 mesenchymal mesenchymal JJ cord-328352-l1q4uvxl 117 12 stem stem NN cord-328352-l1q4uvxl 117 13 cells cell NNS cord-328352-l1q4uvxl 117 14 ( ( -LRB- cord-328352-l1q4uvxl 117 15 uc uc NNP cord-328352-l1q4uvxl 117 16 - - HYPH cord-328352-l1q4uvxl 117 17 mscs mscs NNP cord-328352-l1q4uvxl 117 18 ) ) -RRB- cord-328352-l1q4uvxl 117 19 as as IN cord-328352-l1q4uvxl 117 20 a a DT cord-328352-l1q4uvxl 117 21 therapeutic therapeutic JJ cord-328352-l1q4uvxl 117 22 strategy strategy NN cord-328352-l1q4uvxl 117 23 in in IN cord-328352-l1q4uvxl 117 24 managing manage VBG cord-328352-l1q4uvxl 117 25 critically critically RB cord-328352-l1q4uvxl 117 26 ill ill JJ cord-328352-l1q4uvxl 117 27 covid-19 covid-19 CD cord-328352-l1q4uvxl 117 28 patients patient NNS cord-328352-l1q4uvxl 117 29 : : : cord-328352-l1q4uvxl 117 30 the the DT cord-328352-l1q4uvxl 117 31 case case NN cord-328352-l1q4uvxl 117 32 for for IN cord-328352-l1q4uvxl 117 33 compassionate compassionate JJ cord-328352-l1q4uvxl 117 34 use use NN cord-328352-l1q4uvxl 117 35 Transplantation transplantation NN cord-328352-l1q4uvxl 117 36 of of IN cord-328352-l1q4uvxl 117 37 ACE2 ACE2 NNP cord-328352-l1q4uvxl 117 38 À À , cord-328352-l1q4uvxl 117 39 mesenchymal mesenchymal JJ cord-328352-l1q4uvxl 117 40 stem stem NN cord-328352-l1q4uvxl 117 41 cells cell NNS cord-328352-l1q4uvxl 117 42 improves improve VBZ cord-328352-l1q4uvxl 117 43 the the DT cord-328352-l1q4uvxl 117 44 outcome outcome NN cord-328352-l1q4uvxl 117 45 of of IN cord-328352-l1q4uvxl 117 46 patients patient NNS cord-328352-l1q4uvxl 117 47 with with IN cord-328352-l1q4uvxl 117 48 covid-19 covid-19 NNP cord-328352-l1q4uvxl 117 49 pneumonia pneumonia NN cord-328352-l1q4uvxl 117 50 Exosomes Exosomes NNP cord-328352-l1q4uvxl 117 51 derived derive VBN cord-328352-l1q4uvxl 117 52 from from IN cord-328352-l1q4uvxl 117 53 bone bone NN cord-328352-l1q4uvxl 117 54 marrow marrow NN cord-328352-l1q4uvxl 117 55 mesenchymal mesenchymal JJ cord-328352-l1q4uvxl 117 56 stem stem NN cord-328352-l1q4uvxl 117 57 cells cell NNS cord-328352-l1q4uvxl 117 58 as as IN cord-328352-l1q4uvxl 117 59 treatment treatment NN cord-328352-l1q4uvxl 117 60 for for IN cord-328352-l1q4uvxl 117 61 severe severe JJ cord-328352-l1q4uvxl 117 62 COVID-19 COVID-19 NNP cord-328352-l1q4uvxl 117 63 Rationale Rationale NNP cord-328352-l1q4uvxl 117 64 for for IN cord-328352-l1q4uvxl 117 65 the the DT cord-328352-l1q4uvxl 117 66 clinical clinical JJ cord-328352-l1q4uvxl 117 67 use use NN cord-328352-l1q4uvxl 117 68 of of IN cord-328352-l1q4uvxl 117 69 adipose adipose NN cord-328352-l1q4uvxl 117 70 - - HYPH cord-328352-l1q4uvxl 117 71 derived derive VBN cord-328352-l1q4uvxl 117 72 mesenchymal mesenchymal JJ cord-328352-l1q4uvxl 117 73 stem stem NN cord-328352-l1q4uvxl 117 74 cells cell NNS cord-328352-l1q4uvxl 117 75 for for IN cord-328352-l1q4uvxl 117 76 COVID-19 covid-19 JJ cord-328352-l1q4uvxl 117 77 patients patient NNS cord-328352-l1q4uvxl 117 78 . . . cord-328352-l1q4uvxl 118 1 Version version NN cord-328352-l1q4uvxl 118 2 2 2 CD cord-328352-l1q4uvxl 118 3 Advancing advance VBG cord-328352-l1q4uvxl 118 4 stem stem NN cord-328352-l1q4uvxl 118 5 cell cell NN cord-328352-l1q4uvxl 118 6 therapy therapy NN cord-328352-l1q4uvxl 118 7 for for IN cord-328352-l1q4uvxl 118 8 repair repair NN cord-328352-l1q4uvxl 118 9 of of IN cord-328352-l1q4uvxl 118 10 damaged damaged JJ cord-328352-l1q4uvxl 118 11 lung lung NN cord-328352-l1q4uvxl 118 12 microvasculature microvasculature NN cord-328352-l1q4uvxl 118 13 in in IN cord-328352-l1q4uvxl 118 14 amyotrophic amyotrophic JJ cord-328352-l1q4uvxl 118 15 lateral lateral JJ cord-328352-l1q4uvxl 118 16 sclerosis sclerosis NN cord-328352-l1q4uvxl 118 17 Human human JJ cord-328352-l1q4uvxl 118 18 umbilical umbilical JJ cord-328352-l1q4uvxl 118 19 cord cord NN cord-328352-l1q4uvxl 118 20 blood blood NN cord-328352-l1q4uvxl 118 21 - - HYPH cord-328352-l1q4uvxl 118 22 derived derive VBN cord-328352-l1q4uvxl 118 23 monocytes monocyte NNS cord-328352-l1q4uvxl 118 24 improve improve VBP cord-328352-l1q4uvxl 118 25 cognitive cognitive JJ cord-328352-l1q4uvxl 118 26 deficits deficit NNS cord-328352-l1q4uvxl 118 27 and and CC cord-328352-l1q4uvxl 118 28 reduce reduce VB cord-328352-l1q4uvxl 118 29 amyloid amyloid NN cord-328352-l1q4uvxl 118 30 - - HYPH cord-328352-l1q4uvxl 118 31 b b NN cord-328352-l1q4uvxl 118 32 pathology pathology NN cord-328352-l1q4uvxl 118 33 in in IN cord-328352-l1q4uvxl 118 34 PSAPP PSAPP NNP cord-328352-l1q4uvxl 118 35 mice mouse NNS cord-328352-l1q4uvxl 119 1 Monocytes monocyte NNS cord-328352-l1q4uvxl 119 2 are be VBP cord-328352-l1q4uvxl 119 3 essential essential JJ cord-328352-l1q4uvxl 119 4 for for IN cord-328352-l1q4uvxl 119 5 the the DT cord-328352-l1q4uvxl 119 6 neuroprotective neuroprotective JJ cord-328352-l1q4uvxl 119 7 effect effect NN cord-328352-l1q4uvxl 119 8 of of IN cord-328352-l1q4uvxl 119 9 human human JJ cord-328352-l1q4uvxl 119 10 cord cord NN cord-328352-l1q4uvxl 119 11 blood blood NN cord-328352-l1q4uvxl 119 12 cells cell NNS cord-328352-l1q4uvxl 119 13 following follow VBG cord-328352-l1q4uvxl 119 14 middle middle JJ cord-328352-l1q4uvxl 119 15 cerebral cerebral JJ cord-328352-l1q4uvxl 119 16 artery artery NN cord-328352-l1q4uvxl 119 17 occlusion occlusion NN cord-328352-l1q4uvxl 119 18 in in IN cord-328352-l1q4uvxl 119 19 rat rat NN cord-328352-l1q4uvxl 119 20 A a DT cord-328352-l1q4uvxl 119 21 gut gut NN cord-328352-l1q4uvxl 119 22 feeling feeling NN cord-328352-l1q4uvxl 119 23 about about IN cord-328352-l1q4uvxl 119 24 stroke stroke NN cord-328352-l1q4uvxl 119 25 reveals reveal VBZ cord-328352-l1q4uvxl 119 26 gut gut NN cord-328352-l1q4uvxl 119 27 - - HYPH cord-328352-l1q4uvxl 119 28 brain brain NN cord-328352-l1q4uvxl 119 29 axis axis NN cord-328352-l1q4uvxl 119 30 ' ' '' cord-328352-l1q4uvxl 119 31 active active JJ cord-328352-l1q4uvxl 119 32 role role NN cord-328352-l1q4uvxl 119 33 in in IN cord-328352-l1q4uvxl 119 34 homeostasis homeostasis NN cord-328352-l1q4uvxl 119 35 and and CC cord-328352-l1q4uvxl 119 36 dysbiosis dysbiosis NN cord-328352-l1q4uvxl 119 37 Gut gut NN cord-328352-l1q4uvxl 119 38 microbiome microbiome NN cord-328352-l1q4uvxl 119 39 : : : cord-328352-l1q4uvxl 119 40 lactation lactation NN cord-328352-l1q4uvxl 119 41 , , , cord-328352-l1q4uvxl 119 42 childbirth childbirth NN cord-328352-l1q4uvxl 119 43 , , , cord-328352-l1q4uvxl 119 44 lung lung NN cord-328352-l1q4uvxl 119 45 dysbiosis dysbiosis NN cord-328352-l1q4uvxl 119 46 , , , cord-328352-l1q4uvxl 119 47 animal animal NN cord-328352-l1q4uvxl 119 48 modeling modeling NN cord-328352-l1q4uvxl 119 49 , , , cord-328352-l1q4uvxl 119 50 stem stem NN cord-328352-l1q4uvxl 119 51 cell cell NN cord-328352-l1q4uvxl 119 52 treatment treatment NN cord-328352-l1q4uvxl 119 53 , , , cord-328352-l1q4uvxl 119 54 and and CC cord-328352-l1q4uvxl 119 55 CNS CNS NNP cord-328352-l1q4uvxl 119 56 disorders disorder NNS cord-328352-l1q4uvxl 120 1 A a DT cord-328352-l1q4uvxl 120 2 gutsy gutsy JJ cord-328352-l1q4uvxl 120 3 move move NN cord-328352-l1q4uvxl 120 4 for for IN cord-328352-l1q4uvxl 120 5 cell cell NN cord-328352-l1q4uvxl 120 6 - - HYPH cord-328352-l1q4uvxl 120 7 based base VBN cord-328352-l1q4uvxl 120 8 regenerative regenerative JJ cord-328352-l1q4uvxl 120 9 medicine medicine NN cord-328352-l1q4uvxl 120 10 in in IN cord-328352-l1q4uvxl 120 11 Parkinson Parkinson NNP cord-328352-l1q4uvxl 120 12 's 's POS cord-328352-l1q4uvxl 120 13 disease disease NN cord-328352-l1q4uvxl 120 14 : : : cord-328352-l1q4uvxl 120 15 targeting target VBG cord-328352-l1q4uvxl 120 16 the the DT cord-328352-l1q4uvxl 120 17 gut gut NN cord-328352-l1q4uvxl 120 18 microbiome microbiome NN cord-328352-l1q4uvxl 120 19 to to TO cord-328352-l1q4uvxl 120 20 sequester sequester VB cord-328352-l1q4uvxl 120 21 inflammation inflammation NN cord-328352-l1q4uvxl 120 22 and and CC cord-328352-l1q4uvxl 120 23 neurotoxicity neurotoxicity NN cord-328352-l1q4uvxl 120 24 Gutting gutte VBG cord-328352-l1q4uvxl 120 25 the the DT cord-328352-l1q4uvxl 120 26 brain brain NN cord-328352-l1q4uvxl 120 27 of of IN cord-328352-l1q4uvxl 120 28 inflammation inflammation NN cord-328352-l1q4uvxl 120 29 : : : cord-328352-l1q4uvxl 120 30 a a DT cord-328352-l1q4uvxl 120 31 key key JJ cord-328352-l1q4uvxl 120 32 role role NN cord-328352-l1q4uvxl 120 33 of of IN cord-328352-l1q4uvxl 120 34 gut gut NN cord-328352-l1q4uvxl 120 35 microbiome microbiome NN cord-328352-l1q4uvxl 120 36 in in IN cord-328352-l1q4uvxl 120 37 human human JJ cord-328352-l1q4uvxl 120 38 umbilical umbilical JJ cord-328352-l1q4uvxl 120 39 cord cord NN cord-328352-l1q4uvxl 120 40 blood blood NN cord-328352-l1q4uvxl 120 41 plasma plasma NN cord-328352-l1q4uvxl 120 42 therapy therapy NN cord-328352-l1q4uvxl 120 43 in in IN cord-328352-l1q4uvxl 120 44 Parkinson Parkinson NNP cord-328352-l1q4uvxl 120 45 's 's POS cord-328352-l1q4uvxl 120 46 disease disease NN cord-328352-l1q4uvxl 120 47 model model NN cord-328352-l1q4uvxl 120 48 Probiotics probiotic NNS cord-328352-l1q4uvxl 120 49 and and CC cord-328352-l1q4uvxl 120 50 prebiotics prebiotic NNS cord-328352-l1q4uvxl 120 51 as as IN cord-328352-l1q4uvxl 120 52 a a DT cord-328352-l1q4uvxl 120 53 therapeutic therapeutic JJ cord-328352-l1q4uvxl 120 54 strategy strategy NN cord-328352-l1q4uvxl 120 55 to to TO cord-328352-l1q4uvxl 120 56 improve improve VB cord-328352-l1q4uvxl 120 57 memory memory NN cord-328352-l1q4uvxl 120 58 in in IN cord-328352-l1q4uvxl 120 59 a a DT cord-328352-l1q4uvxl 120 60 model model NN cord-328352-l1q4uvxl 120 61 of of IN cord-328352-l1q4uvxl 120 62 middle middle NN cord-328352-l1q4uvxl 120 63 - - HYPH cord-328352-l1q4uvxl 120 64 aged aged JJ cord-328352-l1q4uvxl 120 65 rats rat NNS cord-328352-l1q4uvxl 120 66 Characteristics characteristic NNS cord-328352-l1q4uvxl 120 67 and and CC cord-328352-l1q4uvxl 120 68 outcomes outcome NNS cord-328352-l1q4uvxl 120 69 of of IN cord-328352-l1q4uvxl 120 70 coronavirus coronavirus NN cord-328352-l1q4uvxl 120 71 disease disease NN cord-328352-l1q4uvxl 120 72 patients patient NNS cord-328352-l1q4uvxl 120 73 under under IN cord-328352-l1q4uvxl 120 74 nonsurge nonsurge NNP cord-328352-l1q4uvxl 120 75 conditions condition NNS cord-328352-l1q4uvxl 120 76 Time Time NNP cord-328352-l1q4uvxl 120 77 - - HYPH cord-328352-l1q4uvxl 120 78 to to IN cord-328352-l1q4uvxl 120 79 - - HYPH cord-328352-l1q4uvxl 120 80 death death NN cord-328352-l1q4uvxl 120 81 approach approach NN cord-328352-l1q4uvxl 120 82 in in IN cord-328352-l1q4uvxl 120 83 revealing reveal VBG cord-328352-l1q4uvxl 120 84 chronicity chronicity NN cord-328352-l1q4uvxl 120 85 and and CC cord-328352-l1q4uvxl 120 86 severity severity NN cord-328352-l1q4uvxl 120 87 of of IN cord-328352-l1q4uvxl 120 88 covid-19 covid-19 NN cord-328352-l1q4uvxl 120 89 across across IN cord-328352-l1q4uvxl 120 90 the the DT cord-328352-l1q4uvxl 120 91 world world NN cord-328352-l1q4uvxl 121 1 A a DT cord-328352-l1q4uvxl 121 2 geroscience geroscience NN cord-328352-l1q4uvxl 121 3 perspective perspective NN cord-328352-l1q4uvxl 121 4 on on IN cord-328352-l1q4uvxl 121 5 COVID-19 COVID-19 NNP cord-328352-l1q4uvxl 121 6 mortality mortality NN cord-328352-l1q4uvxl 121 7 Neurologic neurologic JJ cord-328352-l1q4uvxl 121 8 complications complication NNS cord-328352-l1q4uvxl 121 9 of of IN cord-328352-l1q4uvxl 121 10 COVID-19 COVID-19 NNP cord-328352-l1q4uvxl 121 11 COVID-19 COVID-19 NNP cord-328352-l1q4uvxl 121 12 and and CC cord-328352-l1q4uvxl 121 13 the the DT cord-328352-l1q4uvxl 121 14 cerebro cerebro NNP cord-328352-l1q4uvxl 121 15 - - HYPH cord-328352-l1q4uvxl 121 16 cardiovascular cardiovascular JJ cord-328352-l1q4uvxl 121 17 systems system NNS cord-328352-l1q4uvxl 122 1 : : : cord-328352-l1q4uvxl 122 2 what what WP cord-328352-l1q4uvxl 122 3 do do VBP cord-328352-l1q4uvxl 122 4 we -PRON- PRP cord-328352-l1q4uvxl 122 5 know know VB cord-328352-l1q4uvxl 122 6 so so RB cord-328352-l1q4uvxl 122 7 far far RB cord-328352-l1q4uvxl 122 8 ? ? . cord-328352-l1q4uvxl 123 1 Potential potential JJ cord-328352-l1q4uvxl 123 2 effects effect NNS cord-328352-l1q4uvxl 123 3 of of IN cord-328352-l1q4uvxl 123 4 coronaviruses coronaviruse NNS cord-328352-l1q4uvxl 123 5 on on IN cord-328352-l1q4uvxl 123 6 the the DT cord-328352-l1q4uvxl 123 7 cardiovascular cardiovascular JJ cord-328352-l1q4uvxl 123 8 system system NN cord-328352-l1q4uvxl 123 9 : : : cord-328352-l1q4uvxl 123 10 a a DT cord-328352-l1q4uvxl 123 11 review review NN cord-328352-l1q4uvxl 123 12 Excess excess JJ cord-328352-l1q4uvxl 123 13 neurological neurological JJ cord-328352-l1q4uvxl 123 14 death death NN cord-328352-l1q4uvxl 123 15 in in IN cord-328352-l1q4uvxl 123 16 New New NNP cord-328352-l1q4uvxl 123 17 York York NNP cord-328352-l1q4uvxl 123 18 City City NNP cord-328352-l1q4uvxl 123 19 after after IN cord-328352-l1q4uvxl 123 20 the the DT cord-328352-l1q4uvxl 123 21 emergence emergence NN cord-328352-l1q4uvxl 123 22 of of IN cord-328352-l1q4uvxl 123 23 COVID-19 COVID-19 NNP cord-328352-l1q4uvxl 123 24 A a DT cord-328352-l1q4uvxl 123 25 systematic systematic JJ cord-328352-l1q4uvxl 123 26 review review NN cord-328352-l1q4uvxl 123 27 of of IN cord-328352-l1q4uvxl 123 28 neurological neurological JJ cord-328352-l1q4uvxl 123 29 symptoms symptom NNS cord-328352-l1q4uvxl 123 30 and and CC cord-328352-l1q4uvxl 123 31 complications complication NNS cord-328352-l1q4uvxl 123 32 of of IN cord-328352-l1q4uvxl 123 33 COVID-19 COVID-19 NNP