id sid tid token lemma pos cord-325324-kh2aal5n 1 1 key key NNP cord-325324-kh2aal5n 1 2 : : : cord-325324-kh2aal5n 1 3 cord-325324-kh2aal5n cord-325324-kh2aal5n NNP cord-325324-kh2aal5n 1 4 authors author NNS cord-325324-kh2aal5n 1 5 : : : cord-325324-kh2aal5n 1 6 Teng Teng NNP cord-325324-kh2aal5n 1 7 , , , cord-325324-kh2aal5n 1 8 Shaolei Shaolei NNP cord-325324-kh2aal5n 1 9 ; ; : cord-325324-kh2aal5n 1 10 Tang Tang NNP cord-325324-kh2aal5n 1 11 , , , cord-325324-kh2aal5n 1 12 Qiyi Qiyi NNP cord-325324-kh2aal5n 1 13 title title NN cord-325324-kh2aal5n 1 14 : : : cord-325324-kh2aal5n 2 1 ACE2 ACE2 NNP cord-325324-kh2aal5n 2 2 Enhance enhance NN cord-325324-kh2aal5n 3 1 Viral Viral NNP cord-325324-kh2aal5n 3 2 Infection Infection NNP cord-325324-kh2aal5n 3 3 or or CC cord-325324-kh2aal5n 3 4 Viral Viral NNP cord-325324-kh2aal5n 3 5 Infection infection NN cord-325324-kh2aal5n 3 6 Aggravate aggravate VBP cord-325324-kh2aal5n 3 7 the the DT cord-325324-kh2aal5n 3 8 Underlying underlie VBG cord-325324-kh2aal5n 3 9 Diseases Diseases NNPS cord-325324-kh2aal5n 3 10 date date NN cord-325324-kh2aal5n 3 11 : : : cord-325324-kh2aal5n 3 12 2020 2020 CD cord-325324-kh2aal5n 3 13 - - HYPH cord-325324-kh2aal5n 3 14 08 08 CD cord-325324-kh2aal5n 3 15 - - HYPH cord-325324-kh2aal5n 3 16 06 06 CD cord-325324-kh2aal5n 3 17 journal journal NN cord-325324-kh2aal5n 3 18 : : : cord-325324-kh2aal5n 4 1 Comput Comput NNP cord-325324-kh2aal5n 4 2 Struct Struct NNP cord-325324-kh2aal5n 4 3 Biotechnol Biotechnol NNP cord-325324-kh2aal5n 5 1 J J NNP cord-325324-kh2aal5n 5 2 DOI DOI NNP cord-325324-kh2aal5n 5 3 : : : cord-325324-kh2aal5n 5 4 10.1016/ 10.1016/ CD cord-325324-kh2aal5n 6 1 j.csbj.2020.08.002 j.csbj.2020.08.002 NNP cord-325324-kh2aal5n 7 1 sha sha NNP cord-325324-kh2aal5n 7 2 : : : cord-325324-kh2aal5n 7 3 5e2fbae1a0c680f3b7ded64706cb701ee80291a4 5e2fbae1a0c680f3b7ded64706cb701ee80291a4 NNP cord-325324-kh2aal5n 7 4 doc_id doc_id CD cord-325324-kh2aal5n 8 1 : : : cord-325324-kh2aal5n 8 2 325324 325324 CD cord-325324-kh2aal5n 8 3 cord_uid cord_uid NNS cord-325324-kh2aal5n 8 4 : : : cord-325324-kh2aal5n 9 1 kh2aal5n kh2aal5n NNP cord-325324-kh2aal5n 9 2 ACE2 ACE2 NNP cord-325324-kh2aal5n 9 3 plays play VBZ cord-325324-kh2aal5n 9 4 a a DT cord-325324-kh2aal5n 9 5 critical critical JJ cord-325324-kh2aal5n 9 6 role role NN cord-325324-kh2aal5n 9 7 in in IN cord-325324-kh2aal5n 9 8 SARS SARS NNP cord-325324-kh2aal5n 9 9 - - HYPH cord-325324-kh2aal5n 9 10 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 9 11 infection infection NN cord-325324-kh2aal5n 9 12 to to TO cord-325324-kh2aal5n 9 13 cause cause VB cord-325324-kh2aal5n 9 14 COVID-19 COVID-19 NNP cord-325324-kh2aal5n 9 15 and and CC cord-325324-kh2aal5n 9 16 SARS SARS NNP cord-325324-kh2aal5n 9 17 - - HYPH cord-325324-kh2aal5n 9 18 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 9 19 spike spike NN cord-325324-kh2aal5n 9 20 protein protein NN cord-325324-kh2aal5n 9 21 binds bind VBZ cord-325324-kh2aal5n 9 22 to to IN cord-325324-kh2aal5n 9 23 ACE2 ACE2 NNP cord-325324-kh2aal5n 9 24 and and CC cord-325324-kh2aal5n 9 25 probably probably RB cord-325324-kh2aal5n 9 26 functionally functionally RB cord-325324-kh2aal5n 9 27 inhibits inhibit VBZ cord-325324-kh2aal5n 9 28 ACE2 ACE2 NNP cord-325324-kh2aal5n 9 29 to to TO cord-325324-kh2aal5n 9 30 aggravate aggravate VB cord-325324-kh2aal5n 9 31 the the DT cord-325324-kh2aal5n 9 32 underlying underlie VBG cord-325324-kh2aal5n 9 33 diseases disease NNS cord-325324-kh2aal5n 9 34 of of IN cord-325324-kh2aal5n 9 35 COVID-19 covid-19 NN cord-325324-kh2aal5n 9 36 . . . cord-325324-kh2aal5n 10 1 The the DT cord-325324-kh2aal5n 10 2 important important JJ cord-325324-kh2aal5n 10 3 factors factor NNS cord-325324-kh2aal5n 10 4 that that WDT cord-325324-kh2aal5n 10 5 affect affect VBP cord-325324-kh2aal5n 10 6 the the DT cord-325324-kh2aal5n 10 7 severity severity NN cord-325324-kh2aal5n 10 8 and and CC cord-325324-kh2aal5n 10 9 fatality fatality NN cord-325324-kh2aal5n 10 10 of of IN cord-325324-kh2aal5n 10 11 COVID-19 COVID-19 NNP cord-325324-kh2aal5n 10 12 include include VBP cord-325324-kh2aal5n 10 13 patients patient NNS cord-325324-kh2aal5n 10 14 ' ' POS cord-325324-kh2aal5n 10 15 underlying underlie VBG cord-325324-kh2aal5n 10 16 diseases disease NNS cord-325324-kh2aal5n 10 17 and and CC cord-325324-kh2aal5n 10 18 ages age NNS cord-325324-kh2aal5n 10 19 . . . cord-325324-kh2aal5n 11 1 Therefore therefore RB cord-325324-kh2aal5n 11 2 , , , cord-325324-kh2aal5n 11 3 particular particular JJ cord-325324-kh2aal5n 11 4 care care NN cord-325324-kh2aal5n 11 5 to to IN cord-325324-kh2aal5n 11 6 the the DT cord-325324-kh2aal5n 11 7 patients patient NNS cord-325324-kh2aal5n 11 8 with with IN cord-325324-kh2aal5n 11 9 underlying underlie VBG cord-325324-kh2aal5n 11 10 diseases disease NNS cord-325324-kh2aal5n 11 11 is be VBZ cord-325324-kh2aal5n 11 12 needed need VBN cord-325324-kh2aal5n 11 13 during during IN cord-325324-kh2aal5n 11 14 the the DT cord-325324-kh2aal5n 11 15 treatment treatment NN cord-325324-kh2aal5n 11 16 of of IN cord-325324-kh2aal5n 11 17 COVID-19 covid-19 JJ cord-325324-kh2aal5n 11 18 patients patient NNS cord-325324-kh2aal5n 11 19 . . . cord-325324-kh2aal5n 12 1 severe severe JJ cord-325324-kh2aal5n 12 2 acute acute JJ cord-325324-kh2aal5n 12 3 respiratory respiratory JJ cord-325324-kh2aal5n 12 4 syndrome syndrome NN cord-325324-kh2aal5n 12 5 ( ( -LRB- cord-325324-kh2aal5n 12 6 SARS SARS NNP cord-325324-kh2aal5n 12 7 ) ) -RRB- cord-325324-kh2aal5n 12 8 . . . cord-325324-kh2aal5n 13 1 This this DT cord-325324-kh2aal5n 13 2 was be VBD cord-325324-kh2aal5n 13 3 also also RB cord-325324-kh2aal5n 13 4 called call VBN cord-325324-kh2aal5n 13 5 SARS-1 SARS-1 NNP cord-325324-kh2aal5n 13 6 and and CC cord-325324-kh2aal5n 13 7 the the DT cord-325324-kh2aal5n 13 8 virus virus NN cord-325324-kh2aal5n 13 9 was be VBD cord-325324-kh2aal5n 13 10 named name VBN cord-325324-kh2aal5n 13 11 SARS SARS NNP cord-325324-kh2aal5n 13 12 - - HYPH cord-325324-kh2aal5n 13 13 CoV-1 CoV-1 NNP cord-325324-kh2aal5n 13 14 . . . cord-325324-kh2aal5n 14 1 The the DT cord-325324-kh2aal5n 14 2 second second JJ cord-325324-kh2aal5n 14 3 beta beta NN cord-325324-kh2aal5n 14 4 - - HYPH cord-325324-kh2aal5n 14 5 coronavirus coronavirus NN cord-325324-kh2aal5n 14 6 pandemic pandemic NN cord-325324-kh2aal5n 14 7 occurred occur VBD cord-325324-kh2aal5n 14 8 in in IN cord-325324-kh2aal5n 14 9 Middle middle JJ cord-325324-kh2aal5n 14 10 Eastern eastern JJ cord-325324-kh2aal5n 14 11 countries country NNS cord-325324-kh2aal5n 14 12 in in IN cord-325324-kh2aal5n 14 13 2012 2012 CD cord-325324-kh2aal5n 14 14 and and CC cord-325324-kh2aal5n 14 15 was be VBD cord-325324-kh2aal5n 14 16 hence hence RB cord-325324-kh2aal5n 14 17 named name VBN cord-325324-kh2aal5n 14 18 Middle Middle NNP cord-325324-kh2aal5n 14 19 East East NNP cord-325324-kh2aal5n 14 20 respiratory respiratory JJ cord-325324-kh2aal5n 14 21 syndrome syndrome NN cord-325324-kh2aal5n 14 22 coronavirus coronavirus NN cord-325324-kh2aal5n 14 23 ( ( -LRB- cord-325324-kh2aal5n 14 24 MERS MERS NNP cord-325324-kh2aal5n 14 25 - - HYPH cord-325324-kh2aal5n 14 26 CoV CoV NNP cord-325324-kh2aal5n 14 27 ) ) -RRB- cord-325324-kh2aal5n 14 28 ( ( -LRB- cord-325324-kh2aal5n 14 29 10 10 CD cord-325324-kh2aal5n 14 30 ) ) -RRB- cord-325324-kh2aal5n 14 31 . . . cord-325324-kh2aal5n 15 1 The the DT cord-325324-kh2aal5n 15 2 infection infection NN cord-325324-kh2aal5n 15 3 was be VBD cord-325324-kh2aal5n 15 4 transmitted transmit VBN cord-325324-kh2aal5n 15 5 to to IN cord-325324-kh2aal5n 15 6 25 25 CD cord-325324-kh2aal5n 15 7 countries country NNS cord-325324-kh2aal5n 15 8 and and CC cord-325324-kh2aal5n 15 9 resulted result VBD cord-325324-kh2aal5n 15 10 in in IN cord-325324-kh2aal5n 15 11 1360 1360 CD cord-325324-kh2aal5n 15 12 cases case NNS cord-325324-kh2aal5n 15 13 and and CC cord-325324-kh2aal5n 15 14 527 527 CD cord-325324-kh2aal5n 15 15 deaths death NNS cord-325324-kh2aal5n 15 16 ( ( -LRB- cord-325324-kh2aal5n 15 17 http://www.emro.who.int/pandemic-epidemic-diseases/mers-cov/mers-situation-update-january-2020.html http://www.emro.who.int/pandemic-epidemic-diseases/mers-cov/mers-situation-update-january-2020.html ADD cord-325324-kh2aal5n 15 18 ) ) -RRB- cord-325324-kh2aal5n 15 19 . . . cord-325324-kh2aal5n 16 1 The the DT cord-325324-kh2aal5n 16 2 current current JJ cord-325324-kh2aal5n 16 3 ( ( -LRB- cord-325324-kh2aal5n 16 4 third third JJ cord-325324-kh2aal5n 16 5 ) ) -RRB- cord-325324-kh2aal5n 16 6 pandemic pandemic NN cord-325324-kh2aal5n 16 7 of of IN cord-325324-kh2aal5n 16 8 beta beta NN cord-325324-kh2aal5n 16 9 - - HYPH cord-325324-kh2aal5n 16 10 coronavirus coronavirus NN cord-325324-kh2aal5n 16 11 ( ( -LRB- cord-325324-kh2aal5n 16 12 SARS SARS NNP cord-325324-kh2aal5n 16 13 - - HYPH cord-325324-kh2aal5n 16 14 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 16 15 ) ) -RRB- cord-325324-kh2aal5n 16 16 has have VBZ cord-325324-kh2aal5n 16 17 affected affect VBN cord-325324-kh2aal5n 16 18 almost almost RB cord-325324-kh2aal5n 16 19 all all DT cord-325324-kh2aal5n 16 20 countries country NNS cord-325324-kh2aal5n 16 21 , , , cord-325324-kh2aal5n 16 22 resulting result VBG cord-325324-kh2aal5n 16 23 in in IN cord-325324-kh2aal5n 16 24 the the DT cord-325324-kh2aal5n 16 25 disease disease NN cord-325324-kh2aal5n 16 26 named name VBN cord-325324-kh2aal5n 16 27 COVID-19 COVID-19 NNP cord-325324-kh2aal5n 16 28 . . . cord-325324-kh2aal5n 17 1 Here here RB cord-325324-kh2aal5n 17 2 , , , cord-325324-kh2aal5n 17 3 we -PRON- PRP cord-325324-kh2aal5n 17 4 attempt attempt VBP cord-325324-kh2aal5n 17 5 to to TO cord-325324-kh2aal5n 17 6 analyze analyze VB cord-325324-kh2aal5n 17 7 the the DT cord-325324-kh2aal5n 17 8 available available JJ cord-325324-kh2aal5n 17 9 data datum NNS cord-325324-kh2aal5n 17 10 from from IN cord-325324-kh2aal5n 17 11 publications publication NNS cord-325324-kh2aal5n 17 12 or or CC cord-325324-kh2aal5n 17 13 from from IN cord-325324-kh2aal5n 17 14 official official JJ cord-325324-kh2aal5n 17 15 WHO WHO NNP cord-325324-kh2aal5n 17 16 and and CC cord-325324-kh2aal5n 17 17 USA USA NNP cord-325324-kh2aal5n 17 18 CDC CDC NNP cord-325324-kh2aal5n 17 19 resources resource NNS cord-325324-kh2aal5n 17 20 and and CC cord-325324-kh2aal5n 17 21 underscore underscore VBP cord-325324-kh2aal5n 17 22 the the DT cord-325324-kh2aal5n 17 23 associations association NNS cord-325324-kh2aal5n 17 24 between between IN cord-325324-kh2aal5n 17 25 COVID-19 COVID-19 NNP cord-325324-kh2aal5n 17 26 and and CC cord-325324-kh2aal5n 17 27 its -PRON- PRP$ cord-325324-kh2aal5n 17 28 comorbidities comorbiditie NNS cord-325324-kh2aal5n 17 29 . . . cord-325324-kh2aal5n 18 1 Like like IN cord-325324-kh2aal5n 18 2 other other JJ cord-325324-kh2aal5n 18 3 coronaviruses coronaviruse NNS cord-325324-kh2aal5n 18 4 , , , cord-325324-kh2aal5n 18 5 SARS SARS NNP cord-325324-kh2aal5n 18 6 - - HYPH cord-325324-kh2aal5n 18 7 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 18 8 is be VBZ cord-325324-kh2aal5n 18 9 a a DT cord-325324-kh2aal5n 18 10 single single JJ cord-325324-kh2aal5n 18 11 strand strand NN cord-325324-kh2aal5n 18 12 positive positive JJ cord-325324-kh2aal5n 18 13 RNA RNA NNP cord-325324-kh2aal5n 18 14 virus virus NN cord-325324-kh2aal5n 18 15 with with IN cord-325324-kh2aal5n 18 16 29 29 CD cord-325324-kh2aal5n 18 17 , , , cord-325324-kh2aal5n 18 18 811 811 CD cord-325324-kh2aal5n 18 19 nucleotides nucleotide NNS cord-325324-kh2aal5n 18 20 that that WDT cord-325324-kh2aal5n 18 21 encodes encode VBZ cord-325324-kh2aal5n 18 22 12 12 CD cord-325324-kh2aal5n 18 23 putative putative JJ cord-325324-kh2aal5n 18 24 open open JJ cord-325324-kh2aal5n 18 25 reading reading NN cord-325324-kh2aal5n 18 26 frames frame NNS cord-325324-kh2aal5n 18 27 responsible responsible JJ cord-325324-kh2aal5n 18 28 for for IN cord-325324-kh2aal5n 18 29 more more JJR cord-325324-kh2aal5n 18 30 than than IN cord-325324-kh2aal5n 18 31 26 26 CD cord-325324-kh2aal5n 18 32 proteins protein NNS cord-325324-kh2aal5n 18 33 through through IN cord-325324-kh2aal5n 18 34 ribosomal ribosomal JJ cord-325324-kh2aal5n 18 35 frameshifting frameshifting NN cord-325324-kh2aal5n 18 36 and and CC cord-325324-kh2aal5n 18 37 host host NN cord-325324-kh2aal5n 18 38 proteasomal proteasomal JJ cord-325324-kh2aal5n 18 39 processing processing NN cord-325324-kh2aal5n 18 40 ( ( -LRB- cord-325324-kh2aal5n 18 41 11 11 CD cord-325324-kh2aal5n 18 42 , , , cord-325324-kh2aal5n 18 43 12 12 CD cord-325324-kh2aal5n 18 44 ) ) -RRB- cord-325324-kh2aal5n 18 45 . . . cord-325324-kh2aal5n 19 1 The the DT cord-325324-kh2aal5n 19 2 first first JJ cord-325324-kh2aal5n 19 3 step step NN cord-325324-kh2aal5n 19 4 of of IN cord-325324-kh2aal5n 19 5 viral viral JJ cord-325324-kh2aal5n 19 6 infection infection NN cord-325324-kh2aal5n 19 7 is be VBZ cord-325324-kh2aal5n 19 8 attachment attachment NN cord-325324-kh2aal5n 19 9 , , , cord-325324-kh2aal5n 19 10 which which WDT cord-325324-kh2aal5n 19 11 depends depend VBZ cord-325324-kh2aal5n 19 12 on on IN cord-325324-kh2aal5n 19 13 the the DT cord-325324-kh2aal5n 19 14 interaction interaction NN cord-325324-kh2aal5n 19 15 of of IN cord-325324-kh2aal5n 19 16 the the DT cord-325324-kh2aal5n 19 17 viral viral JJ cord-325324-kh2aal5n 19 18 surface surface NN cord-325324-kh2aal5n 19 19 with with IN cord-325324-kh2aal5n 19 20 cellular cellular JJ cord-325324-kh2aal5n 19 21 receptors receptor NNS cord-325324-kh2aal5n 19 22 . . . cord-325324-kh2aal5n 20 1 The the DT cord-325324-kh2aal5n 20 2 SARS SARS NNP cord-325324-kh2aal5n 20 3 - - HYPH cord-325324-kh2aal5n 20 4 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 20 5 spike spike NN cord-325324-kh2aal5n 20 6 protein protein NN cord-325324-kh2aal5n 20 7 ( ( -LRB- cord-325324-kh2aal5n 20 8 S s NN cord-325324-kh2aal5n 20 9 ) ) -RRB- cord-325324-kh2aal5n 20 10 is be VBZ cord-325324-kh2aal5n 20 11 cleaved cleave VBN cord-325324-kh2aal5n 20 12 by by IN cord-325324-kh2aal5n 20 13 the the DT cord-325324-kh2aal5n 20 14 human human JJ cord-325324-kh2aal5n 20 15 furin furin NN cord-325324-kh2aal5n 20 16 enzyme enzyme NN cord-325324-kh2aal5n 20 17 to to TO cord-325324-kh2aal5n 20 18 generate generate VB cord-325324-kh2aal5n 20 19 two two CD cord-325324-kh2aal5n 20 20 subunits subunit NNS cord-325324-kh2aal5n 20 21 , , , cord-325324-kh2aal5n 20 22 S1 S1 NNP cord-325324-kh2aal5n 20 23 and and CC cord-325324-kh2aal5n 20 24 S2 S2 NNP cord-325324-kh2aal5n 20 25 , , , cord-325324-kh2aal5n 20 26 that that WDT cord-325324-kh2aal5n 20 27 are be VBP cord-325324-kh2aal5n 20 28 arranged arrange VBN cord-325324-kh2aal5n 20 29 to to TO cord-325324-kh2aal5n 20 30 extrude extrude VB cord-325324-kh2aal5n 20 31 outward outward RB cord-325324-kh2aal5n 20 32 from from IN cord-325324-kh2aal5n 20 33 the the DT cord-325324-kh2aal5n 20 34 viral viral JJ cord-325324-kh2aal5n 20 35 particle particle NN cord-325324-kh2aal5n 20 36 . . . cord-325324-kh2aal5n 21 1 Both both DT cord-325324-kh2aal5n 21 2 S1 S1 NNP cord-325324-kh2aal5n 21 3 and and CC cord-325324-kh2aal5n 21 4 S2 S2 NNP cord-325324-kh2aal5n 21 5 play play VBP cord-325324-kh2aal5n 21 6 crucial crucial JJ cord-325324-kh2aal5n 21 7 roles role NNS cord-325324-kh2aal5n 21 8 for for IN cord-325324-kh2aal5n 21 9 viral viral JJ cord-325324-kh2aal5n 21 10 entry entry NN cord-325324-kh2aal5n 21 11 ( ( -LRB- cord-325324-kh2aal5n 21 12 3 3 CD cord-325324-kh2aal5n 21 13 ) ) -RRB- cord-325324-kh2aal5n 21 14 . . . cord-325324-kh2aal5n 22 1 The the DT cord-325324-kh2aal5n 22 2 S1 s1 NN cord-325324-kh2aal5n 22 3 subunit subunit NN cord-325324-kh2aal5n 22 4 binds bind VBZ cord-325324-kh2aal5n 22 5 to to IN cord-325324-kh2aal5n 22 6 the the DT cord-325324-kh2aal5n 22 7 host host NN cord-325324-kh2aal5n 22 8 receptor receptor NN cord-325324-kh2aal5n 22 9 angiotensin angiotensin NN cord-325324-kh2aal5n 22 10 converting convert VBG cord-325324-kh2aal5n 22 11 enzyme enzyme NN cord-325324-kh2aal5n 22 12 2 2 CD cord-325324-kh2aal5n 22 13 ( ( -LRB- cord-325324-kh2aal5n 22 14 ACE2 ACE2 NNP cord-325324-kh2aal5n 22 15 ) ) -RRB- cord-325324-kh2aal5n 23 1 ( ( -LRB- cord-325324-kh2aal5n 23 2 Table table NN cord-325324-kh2aal5n 23 3 1 1 CD cord-325324-kh2aal5n 23 4 ) ) -RRB- cord-325324-kh2aal5n 23 5 . . . cord-325324-kh2aal5n 24 1 While while IN cord-325324-kh2aal5n 24 2 its -PRON- PRP$ cord-325324-kh2aal5n 24 3 binding binding NN cord-325324-kh2aal5n 24 4 to to IN cord-325324-kh2aal5n 24 5 the the DT cord-325324-kh2aal5n 24 6 membrane membrane NN cord-325324-kh2aal5n 24 7 - - HYPH cord-325324-kh2aal5n 24 8 bound bind VBN cord-325324-kh2aal5n 24 9 ACE2 ACE2 NNP cord-325324-kh2aal5n 24 10 promotes promote VBZ cord-325324-kh2aal5n 24 11 viral viral JJ cord-325324-kh2aal5n 24 12 attachment attachment NN cord-325324-kh2aal5n 24 13 to to IN cord-325324-kh2aal5n 24 14 infected infected JJ cord-325324-kh2aal5n 24 15 cells cell NNS cord-325324-kh2aal5n 24 16 , , , cord-325324-kh2aal5n 24 17 the the DT cord-325324-kh2aal5n 24 18 soluble soluble JJ cord-325324-kh2aal5n 24 19 ACE2 ACE2 NNP cord-325324-kh2aal5n 24 20 might may MD cord-325324-kh2aal5n 24 21 prevent prevent VB cord-325324-kh2aal5n 24 22 viral viral JJ cord-325324-kh2aal5n 24 23 infection infection NN cord-325324-kh2aal5n 24 24 by by IN cord-325324-kh2aal5n 24 25 binding bind VBG cord-325324-kh2aal5n 24 26 to to IN cord-325324-kh2aal5n 24 27 S1 S1 NNP cord-325324-kh2aal5n 24 28 ( ( -LRB- cord-325324-kh2aal5n 24 29 13 13 CD cord-325324-kh2aal5n 24 30 ) ) -RRB- cord-325324-kh2aal5n 24 31 . . . cord-325324-kh2aal5n 25 1 The the DT cord-325324-kh2aal5n 25 2 S2 s2 NN cord-325324-kh2aal5n 25 3 subunit subunit NN cord-325324-kh2aal5n 25 4 , , , cord-325324-kh2aal5n 25 5 after after IN cord-325324-kh2aal5n 25 6 S1 S1 NNP cord-325324-kh2aal5n 25 7 's 's POS cord-325324-kh2aal5n 25 8 interaction interaction NN cord-325324-kh2aal5n 25 9 with with IN cord-325324-kh2aal5n 25 10 ACE2 ACE2 NNP cord-325324-kh2aal5n 25 11 , , , cord-325324-kh2aal5n 25 12 promotes promote VBZ cord-325324-kh2aal5n 25 13 viral viral JJ cord-325324-kh2aal5n 25 14 fusion fusion NN cord-325324-kh2aal5n 25 15 with with IN cord-325324-kh2aal5n 25 16 the the DT cord-325324-kh2aal5n 25 17 host host NN cord-325324-kh2aal5n 25 18 cell cell NN cord-325324-kh2aal5n 25 19 membrane membrane NN cord-325324-kh2aal5n 25 20 via via IN cord-325324-kh2aal5n 25 21 interaction interaction NN cord-325324-kh2aal5n 25 22 with with IN cord-325324-kh2aal5n 25 23 transmembrane transmembrane NN cord-325324-kh2aal5n 25 24 protease protease NN cord-325324-kh2aal5n 25 25 , , , cord-325324-kh2aal5n 25 26 serine serine NNP cord-325324-kh2aal5n 25 27 2 2 CD cord-325324-kh2aal5n 25 28 ( ( -LRB- cord-325324-kh2aal5n 25 29 TMPRSS2 TMPRSS2 NNP cord-325324-kh2aal5n 25 30 ) ) -RRB- cord-325324-kh2aal5n 25 31 and and CC cord-325324-kh2aal5n 25 32 enables enable VBZ cord-325324-kh2aal5n 25 33 viral viral JJ cord-325324-kh2aal5n 25 34 entry entry NN cord-325324-kh2aal5n 25 35 ( ( -LRB- cord-325324-kh2aal5n 25 36 3 3 CD cord-325324-kh2aal5n 25 37 ) ) -RRB- cord-325324-kh2aal5n 25 38 . . . cord-325324-kh2aal5n 26 1 Interestingly interestingly RB cord-325324-kh2aal5n 26 2 , , , cord-325324-kh2aal5n 26 3 TMPRSS2 TMPRSS2 NNP cord-325324-kh2aal5n 26 4 has have VBZ cord-325324-kh2aal5n 26 5 the the DT cord-325324-kh2aal5n 26 6 proteolysis proteolysis NN cord-325324-kh2aal5n 26 7 effect effect NN cord-325324-kh2aal5n 26 8 on on IN cord-325324-kh2aal5n 26 9 ACE2 ACE2 NNP cord-325324-kh2aal5n 26 10 , , , cord-325324-kh2aal5n 26 11 which which WDT cord-325324-kh2aal5n 26 12 augments augment VBZ cord-325324-kh2aal5n 26 13 the the DT cord-325324-kh2aal5n 26 14 entry entry NN cord-325324-kh2aal5n 26 15 of of IN cord-325324-kh2aal5n 26 16 SARS SARS NNP cord-325324-kh2aal5n 26 17 - - HYPH cord-325324-kh2aal5n 26 18 CoV-1 CoV-1 NNP cord-325324-kh2aal5n 26 19 and and CC cord-325324-kh2aal5n 26 20 probably probably RB cord-325324-kh2aal5n 26 21 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 26 22 ( ( -LRB- cord-325324-kh2aal5n 26 23 14 14 CD cord-325324-kh2aal5n 26 24 ) ) -RRB- cord-325324-kh2aal5n 27 1 ( ( -LRB- cord-325324-kh2aal5n 27 2 15 15 CD cord-325324-kh2aal5n 27 3 ) ) -RRB- cord-325324-kh2aal5n 27 4 ( ( -LRB- cord-325324-kh2aal5n 27 5 16 16 CD cord-325324-kh2aal5n 27 6 ) ) -RRB- cord-325324-kh2aal5n 27 7 . . . cord-325324-kh2aal5n 28 1 After after IN cord-325324-kh2aal5n 28 2 entry entry NN cord-325324-kh2aal5n 28 3 , , , cord-325324-kh2aal5n 28 4 viral viral JJ cord-325324-kh2aal5n 28 5 particle particle NN cord-325324-kh2aal5n 28 6 is be VBZ cord-325324-kh2aal5n 28 7 endocytosed endocytose VBN cord-325324-kh2aal5n 28 8 to to IN cord-325324-kh2aal5n 28 9 the the DT cord-325324-kh2aal5n 28 10 endosome endosome NN cord-325324-kh2aal5n 28 11 and and CC cord-325324-kh2aal5n 28 12 uncoated uncoate VBN cord-325324-kh2aal5n 28 13 in in IN cord-325324-kh2aal5n 28 14 a a DT cord-325324-kh2aal5n 28 15 pH ph NN cord-325324-kh2aal5n 28 16 - - HYPH cord-325324-kh2aal5n 28 17 related relate VBN cord-325324-kh2aal5n 28 18 manner manner NN cord-325324-kh2aal5n 28 19 . . . cord-325324-kh2aal5n 29 1 Viral Viral NNP cord-325324-kh2aal5n 29 2 RNA RNA NNP cord-325324-kh2aal5n 29 3 is be VBZ cord-325324-kh2aal5n 29 4 released release VBN cord-325324-kh2aal5n 29 5 to to IN cord-325324-kh2aal5n 29 6 the the DT cord-325324-kh2aal5n 29 7 host host NN cord-325324-kh2aal5n 29 8 endoplasmic endoplasmic NN cord-325324-kh2aal5n 29 9 reticulum reticulum NN cord-325324-kh2aal5n 29 10 ( ( -LRB- cord-325324-kh2aal5n 29 11 ER ER NNP cord-325324-kh2aal5n 29 12 ) ) -RRB- cord-325324-kh2aal5n 29 13 . . . cord-325324-kh2aal5n 30 1 Not not RB cord-325324-kh2aal5n 30 2 only only RB cord-325324-kh2aal5n 30 3 do do VBP cord-325324-kh2aal5n 30 4 viral viral JJ cord-325324-kh2aal5n 30 5 protein protein NN cord-325324-kh2aal5n 30 6 translation translation NN cord-325324-kh2aal5n 30 7 and and CC cord-325324-kh2aal5n 30 8 RNA RNA NNP cord-325324-kh2aal5n 30 9 transcription transcription NN cord-325324-kh2aal5n 30 10 happen happen VBP cord-325324-kh2aal5n 30 11 in in IN cord-325324-kh2aal5n 30 12 the the DT cord-325324-kh2aal5n 30 13 ER er NN cord-325324-kh2aal5n 30 14 , , , cord-325324-kh2aal5n 30 15 but but CC cord-325324-kh2aal5n 30 16 also also RB cord-325324-kh2aal5n 30 17 viral viral JJ cord-325324-kh2aal5n 30 18 polyprotein polyprotein JJ cord-325324-kh2aal5n 30 19 processing processing NN cord-325324-kh2aal5n 30 20 : : : cord-325324-kh2aal5n 31 1 viral viral JJ cord-325324-kh2aal5n 31 2 subgenomic subgenomic NNP cord-325324-kh2aal5n 31 3 RNAs RNAs NNPS cord-325324-kh2aal5n 31 4 and and CC cord-325324-kh2aal5n 31 5 stem stem VB cord-325324-kh2aal5n 31 6 looped looped JJ cord-325324-kh2aal5n 31 7 RNAs rna NNS cord-325324-kh2aal5n 31 8 are be VBP cord-325324-kh2aal5n 31 9 formed form VBN cord-325324-kh2aal5n 31 10 in in IN cord-325324-kh2aal5n 31 11 the the DT cord-325324-kh2aal5n 31 12 ER ER NNP cord-325324-kh2aal5n 31 13 . . . cord-325324-kh2aal5n 32 1 Newly newly RB cord-325324-kh2aal5n 32 2 generated generate VBN cord-325324-kh2aal5n 32 3 viral viral JJ cord-325324-kh2aal5n 32 4 particles particle NNS cord-325324-kh2aal5n 32 5 are be VBP cord-325324-kh2aal5n 32 6 assembled assemble VBN cord-325324-kh2aal5n 32 7 in in IN cord-325324-kh2aal5n 32 8 the the DT cord-325324-kh2aal5n 32 9 Golgi Golgi NNP cord-325324-kh2aal5n 32 10 body body NN cord-325324-kh2aal5n 32 11 for for IN cord-325324-kh2aal5n 32 12 exit exit NN cord-325324-kh2aal5n 32 13 out out IN cord-325324-kh2aal5n 32 14 of of IN cord-325324-kh2aal5n 32 15 cells cell NNS cord-325324-kh2aal5n 32 16 . . . cord-325324-kh2aal5n 33 1 The the DT cord-325324-kh2aal5n 33 2 viral viral JJ cord-325324-kh2aal5n 33 3 membrane membrane NN cord-325324-kh2aal5n 33 4 protein protein NN cord-325324-kh2aal5n 33 5 ( ( -LRB- cord-325324-kh2aal5n 33 6 M M NNP cord-325324-kh2aal5n 33 7 ) ) -RRB- cord-325324-kh2aal5n 33 8 , , , cord-325324-kh2aal5n 33 9 important important JJ cord-325324-kh2aal5n 33 10 for for IN cord-325324-kh2aal5n 33 11 maintaining maintain VBG cord-325324-kh2aal5n 33 12 viral viral JJ cord-325324-kh2aal5n 33 13 structure structure NN cord-325324-kh2aal5n 33 14 and and CC cord-325324-kh2aal5n 33 15 the the DT cord-325324-kh2aal5n 33 16 viral viral JJ cord-325324-kh2aal5n 33 17 envelop envelop NN cord-325324-kh2aal5n 33 18 protein protein NN cord-325324-kh2aal5n 33 19 ( ( -LRB- cord-325324-kh2aal5n 33 20 E e NN cord-325324-kh2aal5n 33 21 ) ) -RRB- cord-325324-kh2aal5n 33 22 together together RB cord-325324-kh2aal5n 33 23 play play VB cord-325324-kh2aal5n 33 24 roles role NNS cord-325324-kh2aal5n 33 25 in in IN cord-325324-kh2aal5n 33 26 viral viral JJ cord-325324-kh2aal5n 33 27 assembly assembly NN cord-325324-kh2aal5n 33 28 and and CC cord-325324-kh2aal5n 33 29 release release NN cord-325324-kh2aal5n 33 30 . . . cord-325324-kh2aal5n 34 1 Although although IN cord-325324-kh2aal5n 34 2 the the DT cord-325324-kh2aal5n 34 3 basis basis NN cord-325324-kh2aal5n 34 4 of of IN cord-325324-kh2aal5n 34 5 viral viral JJ cord-325324-kh2aal5n 34 6 replication replication NN cord-325324-kh2aal5n 34 7 is be VBZ cord-325324-kh2aal5n 34 8 outlined outline VBN cord-325324-kh2aal5n 34 9 as as IN cord-325324-kh2aal5n 34 10 above above RB cord-325324-kh2aal5n 34 11 , , , cord-325324-kh2aal5n 34 12 many many JJ cord-325324-kh2aal5n 34 13 aspects aspect NNS cord-325324-kh2aal5n 34 14 are be VBP cord-325324-kh2aal5n 34 15 still still RB cord-325324-kh2aal5n 34 16 not not RB cord-325324-kh2aal5n 34 17 understood understand VBN cord-325324-kh2aal5n 34 18 , , , cord-325324-kh2aal5n 34 19 especially especially RB cord-325324-kh2aal5n 34 20 for for IN cord-325324-kh2aal5n 34 21 the the DT cord-325324-kh2aal5n 34 22 polyprotein polyprotein JJ cord-325324-kh2aal5n 34 23 processing processing NN cord-325324-kh2aal5n 34 24 , , , cord-325324-kh2aal5n 34 25 ribosomal ribosomal JJ cord-325324-kh2aal5n 34 26 frameshifting frameshifting NN cord-325324-kh2aal5n 34 27 and and CC cord-325324-kh2aal5n 34 28 formation formation NN cord-325324-kh2aal5n 34 29 of of IN cord-325324-kh2aal5n 34 30 subgenomic subgenomic NNP cord-325324-kh2aal5n 34 31 RNAs RNAs NNPS cord-325324-kh2aal5n 34 32 . . . cord-325324-kh2aal5n 35 1 We -PRON- PRP cord-325324-kh2aal5n 35 2 will will MD cord-325324-kh2aal5n 35 3 specifically specifically RB cord-325324-kh2aal5n 35 4 discuss discuss VB cord-325324-kh2aal5n 35 5 the the DT cord-325324-kh2aal5n 35 6 interaction interaction NN cord-325324-kh2aal5n 35 7 of of IN cord-325324-kh2aal5n 35 8 SARS SARS NNP cord-325324-kh2aal5n 35 9 - - HYPH cord-325324-kh2aal5n 35 10 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 35 11 with with IN cord-325324-kh2aal5n 35 12 ACE2 ACE2 NNP cord-325324-kh2aal5n 35 13 in in IN cord-325324-kh2aal5n 35 14 this this DT cord-325324-kh2aal5n 35 15 minireview minireview NN cord-325324-kh2aal5n 35 16 . . . cord-325324-kh2aal5n 36 1 Viral viral JJ cord-325324-kh2aal5n 36 2 origin origin NN cord-325324-kh2aal5n 36 3 has have VBZ cord-325324-kh2aal5n 36 4 been be VBN cord-325324-kh2aal5n 36 5 a a DT cord-325324-kh2aal5n 36 6 standing stand VBG cord-325324-kh2aal5n 36 7 hot hot JJ cord-325324-kh2aal5n 36 8 topic topic NN cord-325324-kh2aal5n 36 9 of of IN cord-325324-kh2aal5n 36 10 SARS SARS NNP cord-325324-kh2aal5n 36 11 - - HYPH cord-325324-kh2aal5n 36 12 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 36 13 for for IN cord-325324-kh2aal5n 36 14 a a DT cord-325324-kh2aal5n 36 15 variety variety NN cord-325324-kh2aal5n 36 16 of of IN cord-325324-kh2aal5n 36 17 reasons reason NNS cord-325324-kh2aal5n 36 18 . . . cord-325324-kh2aal5n 37 1 Here here RB cord-325324-kh2aal5n 37 2 we -PRON- PRP cord-325324-kh2aal5n 37 3 trace trace VBP cord-325324-kh2aal5n 37 4 the the DT cord-325324-kh2aal5n 37 5 early early JJ cord-325324-kh2aal5n 37 6 published publish VBN cord-325324-kh2aal5n 37 7 information information NN cord-325324-kh2aal5n 37 8 that that WDT cord-325324-kh2aal5n 37 9 are be VBP cord-325324-kh2aal5n 37 10 more more RBR cord-325324-kh2aal5n 37 11 reliable reliable JJ cord-325324-kh2aal5n 37 12 than than IN cord-325324-kh2aal5n 37 13 those those DT cord-325324-kh2aal5n 37 14 from from IN cord-325324-kh2aal5n 37 15 the the DT cord-325324-kh2aal5n 37 16 mass mass NN cord-325324-kh2aal5n 37 17 media medium NNS cord-325324-kh2aal5n 37 18 . . . cord-325324-kh2aal5n 38 1 The the DT cord-325324-kh2aal5n 38 2 first first JJ cord-325324-kh2aal5n 38 3 two two CD cord-325324-kh2aal5n 38 4 confirmed confirm VBD cord-325324-kh2aal5n 38 5 COVID-19 covid-19 CD cord-325324-kh2aal5n 38 6 cases case NNS cord-325324-kh2aal5n 38 7 occurred occur VBD cord-325324-kh2aal5n 38 8 in in IN cord-325324-kh2aal5n 38 9 Wuhan Wuhan NNP cord-325324-kh2aal5n 38 10 , , , cord-325324-kh2aal5n 38 11 China China NNP cord-325324-kh2aal5n 38 12 on on IN cord-325324-kh2aal5n 38 13 December December NNP cord-325324-kh2aal5n 38 14 8 8 CD cord-325324-kh2aal5n 38 15 th th XX cord-325324-kh2aal5n 38 16 and and CC cord-325324-kh2aal5n 38 17 10 10 CD cord-325324-kh2aal5n 38 18 th th CD cord-325324-kh2aal5n 38 19 of of IN cord-325324-kh2aal5n 38 20 2019 2019 CD cord-325324-kh2aal5n 38 21 . . . cord-325324-kh2aal5n 39 1 The the DT cord-325324-kh2aal5n 39 2 patients patient NNS cord-325324-kh2aal5n 39 3 never never RB cord-325324-kh2aal5n 39 4 went go VBD cord-325324-kh2aal5n 39 5 to to IN cord-325324-kh2aal5n 39 6 the the DT cord-325324-kh2aal5n 39 7 Huanan Huanan NNP cord-325324-kh2aal5n 39 8 seafood seafood NN cord-325324-kh2aal5n 39 9 market market NN cord-325324-kh2aal5n 39 10 that that WDT cord-325324-kh2aal5n 39 11 was be VBD cord-325324-kh2aal5n 39 12 disputed dispute VBN cord-325324-kh2aal5n 39 13 to to TO cord-325324-kh2aal5n 39 14 be be VB cord-325324-kh2aal5n 39 15 a a DT cord-325324-kh2aal5n 39 16 potential potential JJ cord-325324-kh2aal5n 39 17 origin origin NN cord-325324-kh2aal5n 39 18 of of IN cord-325324-kh2aal5n 39 19 SARS SARS NNP cord-325324-kh2aal5n 39 20 - - HYPH cord-325324-kh2aal5n 39 21 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 39 22 . . . cord-325324-kh2aal5n 40 1 In in IN cord-325324-kh2aal5n 40 2 the the DT cord-325324-kh2aal5n 40 3 next next JJ cord-325324-kh2aal5n 40 4 10 10 CD cord-325324-kh2aal5n 40 5 days day NNS cord-325324-kh2aal5n 40 6 ( ( -LRB- cord-325324-kh2aal5n 40 7 December December NNP cord-325324-kh2aal5n 40 8 13 13 CD cord-325324-kh2aal5n 40 9 to to IN cord-325324-kh2aal5n 40 10 23 23 CD cord-325324-kh2aal5n 40 11 ) ) -RRB- cord-325324-kh2aal5n 40 12 , , , cord-325324-kh2aal5n 40 13 more more JJR cord-325324-kh2aal5n 40 14 cases case NNS cord-325324-kh2aal5n 40 15 were be VBD cord-325324-kh2aal5n 40 16 found find VBN cord-325324-kh2aal5n 40 17 . . . cord-325324-kh2aal5n 41 1 Among among IN cord-325324-kh2aal5n 41 2 the the DT cord-325324-kh2aal5n 41 3 total total JJ cord-325324-kh2aal5n 41 4 25 25 CD cord-325324-kh2aal5n 41 5 cases case NNS cord-325324-kh2aal5n 41 6 found find VBN cord-325324-kh2aal5n 41 7 during during IN cord-325324-kh2aal5n 41 8 these these DT cord-325324-kh2aal5n 41 9 10 10 CD cord-325324-kh2aal5n 41 10 days day NNS cord-325324-kh2aal5n 41 11 , , , cord-325324-kh2aal5n 41 12 15 15 CD cord-325324-kh2aal5n 41 13 patients patient NNS cord-325324-kh2aal5n 41 14 went go VBD cord-325324-kh2aal5n 41 15 to to IN cord-325324-kh2aal5n 41 16 the the DT cord-325324-kh2aal5n 41 17 seafood seafood NN cord-325324-kh2aal5n 41 18 market market NN cord-325324-kh2aal5n 41 19 ; ; : cord-325324-kh2aal5n 41 20 therefore therefore RB cord-325324-kh2aal5n 41 21 , , , cord-325324-kh2aal5n 41 22 the the DT cord-325324-kh2aal5n 41 23 seafood seafood NN cord-325324-kh2aal5n 41 24 market market NN cord-325324-kh2aal5n 41 25 was be VBD cord-325324-kh2aal5n 41 26 argued argue VBN cord-325324-kh2aal5n 41 27 to to TO cord-325324-kh2aal5n 41 28 be be VB cord-325324-kh2aal5n 41 29 the the DT cord-325324-kh2aal5n 41 30 origin origin NN cord-325324-kh2aal5n 41 31 of of IN cord-325324-kh2aal5n 41 32 SARS SARS NNP cord-325324-kh2aal5n 41 33 - - HYPH cord-325324-kh2aal5n 41 34 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 41 35 . . . cord-325324-kh2aal5n 42 1 An an DT cord-325324-kh2aal5n 42 2 epidemiological epidemiological JJ cord-325324-kh2aal5n 42 3 analysis analysis NN cord-325324-kh2aal5n 42 4 of of IN cord-325324-kh2aal5n 42 5 the the DT cord-325324-kh2aal5n 42 6 first first JJ cord-325324-kh2aal5n 42 7 425 425 CD cord-325324-kh2aal5n 42 8 cases case NNS cord-325324-kh2aal5n 42 9 in in IN cord-325324-kh2aal5n 42 10 Wuhan Wuhan NNP cord-325324-kh2aal5n 42 11 found find VBD cord-325324-kh2aal5n 42 12 that that IN cord-325324-kh2aal5n 42 13 most most RBS cord-325324-kh2aal5n 42 14 subsequently subsequently RB cord-325324-kh2aal5n 42 15 obtained obtain VBN cord-325324-kh2aal5n 42 16 infections infection NNS cord-325324-kh2aal5n 42 17 were be VBD cord-325324-kh2aal5n 42 18 not not RB cord-325324-kh2aal5n 42 19 originated originate VBN cord-325324-kh2aal5n 42 20 from from IN cord-325324-kh2aal5n 42 21 the the DT cord-325324-kh2aal5n 42 22 Huanan Huanan NNP cord-325324-kh2aal5n 42 23 seafood seafood NN cord-325324-kh2aal5n 42 24 market market NN cord-325324-kh2aal5n 42 25 ( ( -LRB- cord-325324-kh2aal5n 42 26 17 17 CD cord-325324-kh2aal5n 42 27 ) ) -RRB- cord-325324-kh2aal5n 42 28 . . . cord-325324-kh2aal5n 43 1 It -PRON- PRP cord-325324-kh2aal5n 43 2 is be VBZ cord-325324-kh2aal5n 43 3 now now RB cord-325324-kh2aal5n 43 4 more more RBR cord-325324-kh2aal5n 43 5 or or CC cord-325324-kh2aal5n 43 6 less less RBR cord-325324-kh2aal5n 43 7 denied deny VBN cord-325324-kh2aal5n 43 8 by by IN cord-325324-kh2aal5n 43 9 epidemiologists epidemiologist NNS cord-325324-kh2aal5n 43 10 that that IN cord-325324-kh2aal5n 43 11 the the DT cord-325324-kh2aal5n 43 12 Huanan Huanan NNP cord-325324-kh2aal5n 43 13 seafood seafood NN cord-325324-kh2aal5n 43 14 market market NN cord-325324-kh2aal5n 43 15 could could MD cord-325324-kh2aal5n 43 16 have have VB cord-325324-kh2aal5n 43 17 any any DT cord-325324-kh2aal5n 43 18 link link NN cord-325324-kh2aal5n 43 19 with with IN cord-325324-kh2aal5n 43 20 the the DT cord-325324-kh2aal5n 43 21 virus virus NN cord-325324-kh2aal5n 43 22 ( ( -LRB- cord-325324-kh2aal5n 43 23 18 18 CD cord-325324-kh2aal5n 43 24 , , , cord-325324-kh2aal5n 43 25 19 19 CD cord-325324-kh2aal5n 43 26 ) ) -RRB- cord-325324-kh2aal5n 43 27 . . . cord-325324-kh2aal5n 44 1 However however RB cord-325324-kh2aal5n 44 2 , , , cord-325324-kh2aal5n 44 3 the the DT cord-325324-kh2aal5n 44 4 seafood seafood NN cord-325324-kh2aal5n 44 5 market market NN cord-325324-kh2aal5n 44 6 origin origin NN cord-325324-kh2aal5n 44 7 of of IN cord-325324-kh2aal5n 44 8 SARS SARS NNP cord-325324-kh2aal5n 44 9 - - HYPH cord-325324-kh2aal5n 44 10 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 44 11 became become VBD cord-325324-kh2aal5n 44 12 mythologized mythologized JJ cord-325324-kh2aal5n 44 13 . . . cord-325324-kh2aal5n 45 1 The the DT cord-325324-kh2aal5n 45 2 outbreak outbreak NN cord-325324-kh2aal5n 45 3 in in IN cord-325324-kh2aal5n 45 4 Wuhan Wuhan NNP cord-325324-kh2aal5n 45 5 caused cause VBD cord-325324-kh2aal5n 45 6 the the DT cord-325324-kh2aal5n 45 7 viral viral JJ cord-325324-kh2aal5n 45 8 spreading spreading NN cord-325324-kh2aal5n 45 9 to to IN cord-325324-kh2aal5n 45 10 other other JJ cord-325324-kh2aal5n 45 11 provinces province NNS cord-325324-kh2aal5n 45 12 in in IN cord-325324-kh2aal5n 45 13 China China NNP cord-325324-kh2aal5n 45 14 by by IN cord-325324-kh2aal5n 45 15 late late JJ cord-325324-kh2aal5n 45 16 January January NNP cord-325324-kh2aal5n 45 17 while while IN cord-325324-kh2aal5n 45 18 it -PRON- PRP cord-325324-kh2aal5n 45 19 was be VBD cord-325324-kh2aal5n 45 20 later later RB cord-325324-kh2aal5n 45 21 transmitted transmit VBN cord-325324-kh2aal5n 45 22 to to IN cord-325324-kh2aal5n 45 23 other other JJ cord-325324-kh2aal5n 45 24 countries country NNS cord-325324-kh2aal5n 45 25 : : : cord-325324-kh2aal5n 45 26 first first RB cord-325324-kh2aal5n 45 27 to to IN cord-325324-kh2aal5n 45 28 Thailand Thailand NNP cord-325324-kh2aal5n 45 29 , , , cord-325324-kh2aal5n 45 30 then then RB cord-325324-kh2aal5n 45 31 USA USA NNP cord-325324-kh2aal5n 45 32 , , , cord-325324-kh2aal5n 45 33 France France NNP cord-325324-kh2aal5n 45 34 , , , cord-325324-kh2aal5n 45 35 Germany Germany NNP cord-325324-kh2aal5n 45 36 and and CC cord-325324-kh2aal5n 45 37 Italy Italy NNP cord-325324-kh2aal5n 45 38 . . . cord-325324-kh2aal5n 46 1 Sothern Sothern NNP cord-325324-kh2aal5n 46 2 Korea Korea NNP cord-325324-kh2aal5n 46 3 and and CC cord-325324-kh2aal5n 46 4 Italy Italy NNP cord-325324-kh2aal5n 46 5 are be VBP cord-325324-kh2aal5n 46 6 among among IN cord-325324-kh2aal5n 46 7 the the DT cord-325324-kh2aal5n 46 8 first first JJ cord-325324-kh2aal5n 46 9 countries country NNS cord-325324-kh2aal5n 46 10 with with IN cord-325324-kh2aal5n 46 11 outbreaks outbreak NNS cord-325324-kh2aal5n 46 12 in in IN cord-325324-kh2aal5n 46 13 February February NNP cord-325324-kh2aal5n 46 14 ( ( -LRB- cord-325324-kh2aal5n 46 15 17 17 CD cord-325324-kh2aal5n 46 16 , , , cord-325324-kh2aal5n 46 17 20 20 CD cord-325324-kh2aal5n 46 18 ) ) -RRB- cord-325324-kh2aal5n 46 19 . . . cord-325324-kh2aal5n 47 1 It -PRON- PRP cord-325324-kh2aal5n 47 2 quickly quickly RB cord-325324-kh2aal5n 47 3 became become VBD cord-325324-kh2aal5n 47 4 a a DT cord-325324-kh2aal5n 47 5 pandemic pandemic NN cord-325324-kh2aal5n 47 6 and and CC cord-325324-kh2aal5n 47 7 affects affect VBZ cord-325324-kh2aal5n 47 8 more more JJR cord-325324-kh2aal5n 47 9 than than IN cord-325324-kh2aal5n 47 10 200 200 CD cord-325324-kh2aal5n 47 11 countries country NNS cord-325324-kh2aal5n 47 12 now now RB cord-325324-kh2aal5n 47 13 with with IN cord-325324-kh2aal5n 47 14 more more JJR cord-325324-kh2aal5n 47 15 than than IN cord-325324-kh2aal5n 47 16 3 3 CD cord-325324-kh2aal5n 47 17 million million CD cord-325324-kh2aal5n 47 18 cases case NNS cord-325324-kh2aal5n 47 19 and and CC cord-325324-kh2aal5n 47 20 over over IN cord-325324-kh2aal5n 47 21 200,000 200,000 CD cord-325324-kh2aal5n 47 22 deaths death NNS cord-325324-kh2aal5n 47 23 globally globally RB cord-325324-kh2aal5n 47 24 . . . cord-325324-kh2aal5n 48 1 A a DT cord-325324-kh2aal5n 48 2 previously previously RB cord-325324-kh2aal5n 48 3 isolated isolate VBN cord-325324-kh2aal5n 48 4 bat bat NN cord-325324-kh2aal5n 48 5 coronavirus coronavirus NN cord-325324-kh2aal5n 48 6 ( ( -LRB- cord-325324-kh2aal5n 48 7 BatCoV BatCoV NNP cord-325324-kh2aal5n 48 8 RaTG13 RaTG13 NNP cord-325324-kh2aal5n 48 9 ) ) -RRB- cord-325324-kh2aal5n 48 10 has have VBZ cord-325324-kh2aal5n 48 11 been be VBN cord-325324-kh2aal5n 48 12 identified identify VBN cord-325324-kh2aal5n 48 13 that that IN cord-325324-kh2aal5n 48 14 shares share NNS cord-325324-kh2aal5n 48 15 more more JJR cord-325324-kh2aal5n 48 16 than than IN cord-325324-kh2aal5n 48 17 96 96 CD cord-325324-kh2aal5n 48 18 % % NN cord-325324-kh2aal5n 48 19 homology homology NN cord-325324-kh2aal5n 48 20 in in IN cord-325324-kh2aal5n 48 21 nucleotide nucleotide JJ cord-325324-kh2aal5n 48 22 sequences sequence NNS cord-325324-kh2aal5n 48 23 and and CC cord-325324-kh2aal5n 48 24 more more JJR cord-325324-kh2aal5n 48 25 than than IN cord-325324-kh2aal5n 48 26 97 97 CD cord-325324-kh2aal5n 48 27 % % NN cord-325324-kh2aal5n 48 28 homology homology NN cord-325324-kh2aal5n 48 29 in in IN cord-325324-kh2aal5n 48 30 amino amino NN cord-325324-kh2aal5n 48 31 acid acid NN cord-325324-kh2aal5n 48 32 sequences sequence NNS cord-325324-kh2aal5n 48 33 with with IN cord-325324-kh2aal5n 48 34 SARS SARS NNP cord-325324-kh2aal5n 48 35 - - HYPH cord-325324-kh2aal5n 48 36 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 48 37 ( ( -LRB- cord-325324-kh2aal5n 48 38 21 21 CD cord-325324-kh2aal5n 48 39 ) ) -RRB- cord-325324-kh2aal5n 48 40 . . . cord-325324-kh2aal5n 49 1 This this DT cord-325324-kh2aal5n 49 2 study study NN cord-325324-kh2aal5n 49 3 implied imply VBD cord-325324-kh2aal5n 49 4 that that IN cord-325324-kh2aal5n 49 5 the the DT cord-325324-kh2aal5n 49 6 SARS SARS NNP cord-325324-kh2aal5n 49 7 - - HYPH cord-325324-kh2aal5n 49 8 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 49 9 might may MD cord-325324-kh2aal5n 49 10 have have VB cord-325324-kh2aal5n 49 11 originated originate VBN cord-325324-kh2aal5n 49 12 from from IN cord-325324-kh2aal5n 49 13 bats bat NNS cord-325324-kh2aal5n 49 14 . . . cord-325324-kh2aal5n 50 1 However however RB cord-325324-kh2aal5n 50 2 , , , cord-325324-kh2aal5n 50 3 bats bat NNS cord-325324-kh2aal5n 50 4 are be VBP cord-325324-kh2aal5n 50 5 not not RB cord-325324-kh2aal5n 50 6 a a DT cord-325324-kh2aal5n 50 7 common common JJ cord-325324-kh2aal5n 50 8 resident resident JJ cord-325324-kh2aal5n 50 9 animal animal NN cord-325324-kh2aal5n 50 10 in in IN cord-325324-kh2aal5n 50 11 the the DT cord-325324-kh2aal5n 50 12 city city NN cord-325324-kh2aal5n 50 13 of of IN cord-325324-kh2aal5n 50 14 Wuhan Wuhan NNP cord-325324-kh2aal5n 50 15 . . . cord-325324-kh2aal5n 51 1 Therefore therefore RB cord-325324-kh2aal5n 51 2 , , , cord-325324-kh2aal5n 51 3 an an DT cord-325324-kh2aal5n 51 4 intermediate intermediate JJ cord-325324-kh2aal5n 51 5 host host NN cord-325324-kh2aal5n 51 6 for for IN cord-325324-kh2aal5n 51 7 SARS SARS NNP cord-325324-kh2aal5n 51 8 - - HYPH cord-325324-kh2aal5n 51 9 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 51 10 is be VBZ cord-325324-kh2aal5n 51 11 believed believe VBN cord-325324-kh2aal5n 51 12 to to TO cord-325324-kh2aal5n 51 13 exist exist VB cord-325324-kh2aal5n 51 14 assuming assume VBG cord-325324-kh2aal5n 51 15 it -PRON- PRP cord-325324-kh2aal5n 51 16 is be VBZ cord-325324-kh2aal5n 51 17 a a DT cord-325324-kh2aal5n 51 18 zoonotic zoonotic JJ cord-325324-kh2aal5n 51 19 virus virus NN cord-325324-kh2aal5n 51 20 . . . cord-325324-kh2aal5n 52 1 One one CD cord-325324-kh2aal5n 52 2 study study NN cord-325324-kh2aal5n 52 3 found find VBD cord-325324-kh2aal5n 52 4 that that IN cord-325324-kh2aal5n 52 5 a a DT cord-325324-kh2aal5n 52 6 coronavirus coronavirus NN cord-325324-kh2aal5n 52 7 isolated isolate VBN cord-325324-kh2aal5n 52 8 from from IN cord-325324-kh2aal5n 52 9 the the DT cord-325324-kh2aal5n 52 10 pangolin pangolin NN cord-325324-kh2aal5n 52 11 is be VBZ cord-325324-kh2aal5n 52 12 91.02 91.02 CD cord-325324-kh2aal5n 52 13 % % NN cord-325324-kh2aal5n 52 14 and and CC cord-325324-kh2aal5n 52 15 90.55 90.55 CD cord-325324-kh2aal5n 52 16 % % NN cord-325324-kh2aal5n 52 17 identical identical JJ cord-325324-kh2aal5n 52 18 in in IN cord-325324-kh2aal5n 52 19 nucleotide nucleotide JJ cord-325324-kh2aal5n 52 20 sequences sequence NNS cord-325324-kh2aal5n 52 21 to to IN cord-325324-kh2aal5n 52 22 SARS SARS NNP cord-325324-kh2aal5n 52 23 - - HYPH cord-325324-kh2aal5n 52 24 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 52 25 and and CC cord-325324-kh2aal5n 52 26 BatCoV BatCoV NNP cord-325324-kh2aal5n 52 27 RaTG13 RaTG13 NNP cord-325324-kh2aal5n 52 28 , , , cord-325324-kh2aal5n 52 29 respectively respectively RB cord-325324-kh2aal5n 52 30 ( ( -LRB- cord-325324-kh2aal5n 52 31 22 22 CD cord-325324-kh2aal5n 52 32 ) ) -RRB- cord-325324-kh2aal5n 52 33 . . . cord-325324-kh2aal5n 53 1 Another another DT cord-325324-kh2aal5n 53 2 study study NN cord-325324-kh2aal5n 53 3 showed show VBD cord-325324-kh2aal5n 53 4 that that IN cord-325324-kh2aal5n 53 5 SARS SARS NNP cord-325324-kh2aal5n 53 6 - - HYPH cord-325324-kh2aal5n 53 7 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 53 8 is be VBZ cord-325324-kh2aal5n 53 9 possibly possibly RB cord-325324-kh2aal5n 53 10 associated associate VBN cord-325324-kh2aal5n 53 11 with with IN cord-325324-kh2aal5n 53 12 coronaviruses coronaviruse NNS cord-325324-kh2aal5n 53 13 derived derive VBN cord-325324-kh2aal5n 53 14 from from IN cord-325324-kh2aal5n 53 15 some some DT cord-325324-kh2aal5n 53 16 wild wild JJ cord-325324-kh2aal5n 53 17 animals animal NNS cord-325324-kh2aal5n 53 18 , , , cord-325324-kh2aal5n 53 19 including include VBG cord-325324-kh2aal5n 53 20 Paguma Paguma NNP cord-325324-kh2aal5n 53 21 larvata larvata NNP cord-325324-kh2aal5n 53 22 , , , cord-325324-kh2aal5n 53 23 Paradoxurus Paradoxurus NNP cord-325324-kh2aal5n 53 24 hermaphroditus hermaphroditus NNP cord-325324-kh2aal5n 53 25 , , , cord-325324-kh2aal5n 53 26 in in IN cord-325324-kh2aal5n 53 27 the the DT cord-325324-kh2aal5n 53 28 same same JJ cord-325324-kh2aal5n 53 29 branch branch NN cord-325324-kh2aal5n 53 30 of of IN cord-325324-kh2aal5n 53 31 the the DT cord-325324-kh2aal5n 53 32 phylogenetic phylogenetic JJ cord-325324-kh2aal5n 53 33 tree tree NN cord-325324-kh2aal5n 53 34 ( ( -LRB- cord-325324-kh2aal5n 53 35 23 23 CD cord-325324-kh2aal5n 53 36 ) ) -RRB- cord-325324-kh2aal5n 53 37 . . . cord-325324-kh2aal5n 54 1 However however RB cord-325324-kh2aal5n 54 2 , , , cord-325324-kh2aal5n 54 3 they -PRON- PRP cord-325324-kh2aal5n 54 4 all all DT cord-325324-kh2aal5n 54 5 are be VBP cord-325324-kh2aal5n 54 6 unlikely unlikely JJ cord-325324-kh2aal5n 54 7 the the DT cord-325324-kh2aal5n 54 8 intermediate intermediate JJ cord-325324-kh2aal5n 54 9 host host NN cord-325324-kh2aal5n 54 10 because because IN cord-325324-kh2aal5n 54 11 the the DT cord-325324-kh2aal5n 54 12 genome genome NN cord-325324-kh2aal5n 54 13 and and CC cord-325324-kh2aal5n 54 14 ORF1a ORF1a NNP cord-325324-kh2aal5n 54 15 homology homology NNS cord-325324-kh2aal5n 54 16 show show VBP cord-325324-kh2aal5n 54 17 that that IN cord-325324-kh2aal5n 54 18 the the DT cord-325324-kh2aal5n 54 19 virus virus NN cord-325324-kh2aal5n 54 20 is be VBZ cord-325324-kh2aal5n 54 21 not not RB cord-325324-kh2aal5n 54 22 even even RB cord-325324-kh2aal5n 54 23 close close JJ cord-325324-kh2aal5n 54 24 to to IN cord-325324-kh2aal5n 54 25 SARS SARS NNP cord-325324-kh2aal5n 54 26 - - HYPH cord-325324-kh2aal5n 54 27 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 54 28 . . . cord-325324-kh2aal5n 55 1 Given give VBN cord-325324-kh2aal5n 55 2 SARS SARS NNP cord-325324-kh2aal5n 55 3 - - HYPH cord-325324-kh2aal5n 55 4 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 55 5 is be VBZ cord-325324-kh2aal5n 55 6 originated originate VBN cord-325324-kh2aal5n 55 7 from from IN cord-325324-kh2aal5n 55 8 bat bat NN cord-325324-kh2aal5n 55 9 RaTG13 RaTG13 NNP cord-325324-kh2aal5n 55 10 , , , cord-325324-kh2aal5n 56 1 the the DT cord-325324-kh2aal5n 56 2 virus virus NN cord-325324-kh2aal5n 56 3 from from IN cord-325324-kh2aal5n 56 4 the the DT cord-325324-kh2aal5n 56 5 intermediate intermediate JJ cord-325324-kh2aal5n 56 6 host host NN cord-325324-kh2aal5n 56 7 should should MD cord-325324-kh2aal5n 56 8 be be VB cord-325324-kh2aal5n 56 9 closer close JJR cord-325324-kh2aal5n 56 10 to to IN cord-325324-kh2aal5n 56 11 SARS SARS NNP cord-325324-kh2aal5n 56 12 - - HYPH cord-325324-kh2aal5n 56 13 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 56 14 than than IN cord-325324-kh2aal5n 56 15 to to IN cord-325324-kh2aal5n 56 16 the the DT cord-325324-kh2aal5n 56 17 RaTG13 ratg13 NN cord-325324-kh2aal5n 56 18 . . . cord-325324-kh2aal5n 57 1 Although although IN cord-325324-kh2aal5n 57 2 it -PRON- PRP cord-325324-kh2aal5n 57 3 is be VBZ cord-325324-kh2aal5n 57 4 difficult difficult JJ cord-325324-kh2aal5n 57 5 to to TO cord-325324-kh2aal5n 57 6 find find VB cord-325324-kh2aal5n 57 7 it -PRON- PRP cord-325324-kh2aal5n 57 8 , , , cord-325324-kh2aal5n 57 9 the the DT cord-325324-kh2aal5n 57 10 intermediate intermediate JJ cord-325324-kh2aal5n 57 11 host host NN cord-325324-kh2aal5n 57 12 is be VBZ cord-325324-kh2aal5n 57 13 still still RB cord-325324-kh2aal5n 57 14 the the DT cord-325324-kh2aal5n 57 15 interest interest NN cord-325324-kh2aal5n 57 16 of of IN cord-325324-kh2aal5n 57 17 virologists virologist NNS cord-325324-kh2aal5n 57 18 ( ( -LRB- cord-325324-kh2aal5n 57 19 24 24 CD cord-325324-kh2aal5n 57 20 , , , cord-325324-kh2aal5n 57 21 25 25 CD cord-325324-kh2aal5n 57 22 ) ) -RRB- cord-325324-kh2aal5n 57 23 . . . cord-325324-kh2aal5n 58 1 Surprisingly surprisingly RB cord-325324-kh2aal5n 58 2 , , , cord-325324-kh2aal5n 58 3 a a DT cord-325324-kh2aal5n 58 4 research research NN cord-325324-kh2aal5n 58 5 group group NN cord-325324-kh2aal5n 58 6 screened screen VBD cord-325324-kh2aal5n 58 7 the the DT cord-325324-kh2aal5n 58 8 susceptibilities susceptibility NNS cord-325324-kh2aal5n 58 9 of of IN cord-325324-kh2aal5n 58 10 different different JJ cord-325324-kh2aal5n 58 11 companion companion NN cord-325324-kh2aal5n 58 12 animals animal NNS cord-325324-kh2aal5n 58 13 to to IN cord-325324-kh2aal5n 58 14 SARS SARS NNP cord-325324-kh2aal5n 58 15 - - HYPH cord-325324-kh2aal5n 58 16 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 58 17 infection infection NN cord-325324-kh2aal5n 58 18 and and CC cord-325324-kh2aal5n 58 19 found find VBD cord-325324-kh2aal5n 58 20 that that IN cord-325324-kh2aal5n 58 21 cats cat NNS cord-325324-kh2aal5n 58 22 and and CC cord-325324-kh2aal5n 58 23 ferrets ferret NNS cord-325324-kh2aal5n 58 24 are be VBP cord-325324-kh2aal5n 58 25 very very RB cord-325324-kh2aal5n 58 26 susceptible susceptible JJ cord-325324-kh2aal5n 58 27 to to IN cord-325324-kh2aal5n 58 28 SARS SARS NNP cord-325324-kh2aal5n 58 29 - - HYPH cord-325324-kh2aal5n 58 30 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 58 31 . . . cord-325324-kh2aal5n 59 1 On on IN cord-325324-kh2aal5n 59 2 the the DT cord-325324-kh2aal5n 59 3 contrary contrary NN cord-325324-kh2aal5n 59 4 , , , cord-325324-kh2aal5n 59 5 SARS SARS NNP cord-325324-kh2aal5n 59 6 - - HYPH cord-325324-kh2aal5n 59 7 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 59 8 poorly poorly RB cord-325324-kh2aal5n 59 9 infects infect VBZ cord-325324-kh2aal5n 59 10 and and CC cord-325324-kh2aal5n 59 11 replicates replicate VBZ cord-325324-kh2aal5n 59 12 in in IN cord-325324-kh2aal5n 59 13 dogs dog NNS cord-325324-kh2aal5n 59 14 , , , cord-325324-kh2aal5n 59 15 pigs pig NNS cord-325324-kh2aal5n 59 16 , , , cord-325324-kh2aal5n 59 17 chickens chicken NNS cord-325324-kh2aal5n 59 18 , , , cord-325324-kh2aal5n 59 19 and and CC cord-325324-kh2aal5n 59 20 ducks duck NNS cord-325324-kh2aal5n 59 21 ( ( -LRB- cord-325324-kh2aal5n 59 22 26 26 CD cord-325324-kh2aal5n 59 23 ) ) -RRB- cord-325324-kh2aal5n 59 24 . . . cord-325324-kh2aal5n 60 1 The the DT cord-325324-kh2aal5n 60 2 first first JJ cord-325324-kh2aal5n 60 3 recorded record VBN cord-325324-kh2aal5n 60 4 COVID-19 COVID-19 NNP cord-325324-kh2aal5n 60 5 case case NN cord-325324-kh2aal5n 60 6 in in IN cord-325324-kh2aal5n 60 7 the the DT cord-325324-kh2aal5n 60 8 USA USA NNP cord-325324-kh2aal5n 60 9 was be VBD cord-325324-kh2aal5n 60 10 in in IN cord-325324-kh2aal5n 60 11 Seattle Seattle NNP cord-325324-kh2aal5n 60 12 , , , cord-325324-kh2aal5n 60 13 Washington Washington NNP cord-325324-kh2aal5n 60 14 on on IN cord-325324-kh2aal5n 60 15 January January NNP cord-325324-kh2aal5n 60 16 19 19 CD cord-325324-kh2aal5n 60 17 th th XX cord-325324-kh2aal5n 60 18 , , , cord-325324-kh2aal5n 60 19 2020 2020 CD cord-325324-kh2aal5n 60 20 in in IN cord-325324-kh2aal5n 60 21 a a DT cord-325324-kh2aal5n 60 22 patient patient NN cord-325324-kh2aal5n 60 23 who who WP cord-325324-kh2aal5n 60 24 traveled travel VBD cord-325324-kh2aal5n 60 25 back back RB cord-325324-kh2aal5n 60 26 from from IN cord-325324-kh2aal5n 60 27 Wuhan Wuhan NNP cord-325324-kh2aal5n 60 28 , , , cord-325324-kh2aal5n 60 29 China China NNP cord-325324-kh2aal5n 60 30 . . . cord-325324-kh2aal5n 61 1 Two two CD cord-325324-kh2aal5n 61 2 days day NNS cord-325324-kh2aal5n 61 3 later later RB cord-325324-kh2aal5n 61 4 , , , cord-325324-kh2aal5n 61 5 cases case NNS cord-325324-kh2aal5n 61 6 were be VBD cord-325324-kh2aal5n 61 7 reported report VBN cord-325324-kh2aal5n 61 8 in in IN cord-325324-kh2aal5n 61 9 Chicago Chicago NNP cord-325324-kh2aal5n 61 10 on on IN cord-325324-kh2aal5n 61 11 January January NNP cord-325324-kh2aal5n 61 12 21 21 CD cord-325324-kh2aal5n 61 13 st st NNP cord-325324-kh2aal5n 61 14 , , , cord-325324-kh2aal5n 61 15 2020 2020 CD cord-325324-kh2aal5n 61 16 . . . cord-325324-kh2aal5n 62 1 Another another DT cord-325324-kh2aal5n 62 2 two two CD cord-325324-kh2aal5n 62 3 days day NNS cord-325324-kh2aal5n 62 4 later later RB cord-325324-kh2aal5n 62 5 , , , cord-325324-kh2aal5n 62 6 COVID-19 covid-19 JJ cord-325324-kh2aal5n 62 7 cases case NNS cord-325324-kh2aal5n 62 8 were be VBD cord-325324-kh2aal5n 62 9 confirmed confirm VBN cord-325324-kh2aal5n 62 10 in in IN cord-325324-kh2aal5n 62 11 California California NNP cord-325324-kh2aal5n 62 12 and and CC cord-325324-kh2aal5n 62 13 Arizona Arizona NNP cord-325324-kh2aal5n 62 14 . . . cord-325324-kh2aal5n 63 1 These these DT cord-325324-kh2aal5n 63 2 early early JJ cord-325324-kh2aal5n 63 3 cases case NNS cord-325324-kh2aal5n 63 4 all all DT cord-325324-kh2aal5n 63 5 occurred occur VBD cord-325324-kh2aal5n 63 6 in in IN cord-325324-kh2aal5n 63 7 patients patient NNS cord-325324-kh2aal5n 63 8 who who WP cord-325324-kh2aal5n 63 9 traveled travel VBD cord-325324-kh2aal5n 63 10 from from IN cord-325324-kh2aal5n 63 11 China China NNP cord-325324-kh2aal5n 63 12 . . . cord-325324-kh2aal5n 64 1 Due due IN cord-325324-kh2aal5n 64 2 to to IN cord-325324-kh2aal5n 64 3 its -PRON- PRP$ cord-325324-kh2aal5n 64 4 highly highly RB cord-325324-kh2aal5n 64 5 contagious contagious JJ cord-325324-kh2aal5n 64 6 nature nature NN cord-325324-kh2aal5n 64 7 , , , cord-325324-kh2aal5n 64 8 SARS SARS NNP cord-325324-kh2aal5n 64 9 - - HYPH cord-325324-kh2aal5n 64 10 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 64 11 has have VBZ cord-325324-kh2aal5n 64 12 proven prove VBN cord-325324-kh2aal5n 64 13 catastrophic catastrophic JJ cord-325324-kh2aal5n 64 14 in in IN cord-325324-kh2aal5n 64 15 both both DT cord-325324-kh2aal5n 64 16 prevalence prevalence NN cord-325324-kh2aal5n 64 17 and and CC cord-325324-kh2aal5n 64 18 fatality fatality NN cord-325324-kh2aal5n 64 19 in in IN cord-325324-kh2aal5n 64 20 the the DT cord-325324-kh2aal5n 64 21 United United NNP cord-325324-kh2aal5n 64 22 States States NNP cord-325324-kh2aal5n 64 23 . . . cord-325324-kh2aal5n 65 1 The the DT cord-325324-kh2aal5n 65 2 most most RBS cord-325324-kh2aal5n 65 3 important important JJ cord-325324-kh2aal5n 65 4 difference difference NN cord-325324-kh2aal5n 65 5 between between IN cord-325324-kh2aal5n 65 6 SARS SARS NNP cord-325324-kh2aal5n 65 7 - - HYPH cord-325324-kh2aal5n 65 8 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 65 9 , , , cord-325324-kh2aal5n 65 10 SARS SARS NNP cord-325324-kh2aal5n 65 11 - - HYPH cord-325324-kh2aal5n 65 12 CoV-1 CoV-1 NNP cord-325324-kh2aal5n 65 13 ( ( -LRB- cord-325324-kh2aal5n 65 14 2002 2002 CD cord-325324-kh2aal5n 65 15 ) ) -RRB- cord-325324-kh2aal5n 65 16 and and CC cord-325324-kh2aal5n 65 17 ( ( -LRB- cord-325324-kh2aal5n 65 18 2009 2009 CD cord-325324-kh2aal5n 65 19 ) ) -RRB- cord-325324-kh2aal5n 65 20 is be VBZ cord-325324-kh2aal5n 65 21 that that IN cord-325324-kh2aal5n 65 22 SARS SARS NNP cord-325324-kh2aal5n 65 23 - - HYPH cord-325324-kh2aal5n 65 24 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 65 25 is be VBZ cord-325324-kh2aal5n 65 26 highly highly RB cord-325324-kh2aal5n 65 27 contagious contagious JJ cord-325324-kh2aal5n 65 28 with with IN cord-325324-kh2aal5n 65 29 a a DT cord-325324-kh2aal5n 65 30 much much RB cord-325324-kh2aal5n 65 31 higher high JJR cord-325324-kh2aal5n 65 32 reproductive reproductive JJ cord-325324-kh2aal5n 65 33 number number NN cord-325324-kh2aal5n 65 34 ( ( -LRB- cord-325324-kh2aal5n 65 35 R0 R0 NNP cord-325324-kh2aal5n 65 36 ) ) -RRB- cord-325324-kh2aal5n 65 37 of of IN cord-325324-kh2aal5n 65 38 5.7 5.7 CD cord-325324-kh2aal5n 65 39 ( ( -LRB- cord-325324-kh2aal5n 65 40 27 27 CD cord-325324-kh2aal5n 65 41 ) ) -RRB- cord-325324-kh2aal5n 65 42 or or CC cord-325324-kh2aal5n 65 43 3.57 3.57 CD cord-325324-kh2aal5n 65 44 ( ( -LRB- cord-325324-kh2aal5n 65 45 28 28 CD cord-325324-kh2aal5n 65 46 ) ) -RRB- cord-325324-kh2aal5n 65 47 is be VBZ cord-325324-kh2aal5n 65 48 rapidly rapidly RB cord-325324-kh2aal5n 65 49 spreading spread VBG cord-325324-kh2aal5n 65 50 to to IN cord-325324-kh2aal5n 65 51 other other JJ cord-325324-kh2aal5n 65 52 countries country NNS cord-325324-kh2aal5n 65 53 and and CC cord-325324-kh2aal5n 65 54 territories territory NNS cord-325324-kh2aal5n 65 55 to to TO cord-325324-kh2aal5n 65 56 cause cause VB cord-325324-kh2aal5n 65 57 COVID-19 COVID-19 NNP cord-325324-kh2aal5n 65 58 . . . cord-325324-kh2aal5n 66 1 More more RBR cord-325324-kh2aal5n 66 2 importantly importantly RB cord-325324-kh2aal5n 66 3 , , , cord-325324-kh2aal5n 66 4 epidemic epidemic NN cord-325324-kh2aal5n 66 5 data data NN cord-325324-kh2aal5n 66 6 suggests suggest VBZ cord-325324-kh2aal5n 66 7 that that IN cord-325324-kh2aal5n 66 8 the the DT cord-325324-kh2aal5n 66 9 COVID-19 COVID-19 NNP cord-325324-kh2aal5n 66 10 might may MD cord-325324-kh2aal5n 66 11 become become VB cord-325324-kh2aal5n 66 12 a a DT cord-325324-kh2aal5n 66 13 seasonal seasonal JJ cord-325324-kh2aal5n 66 14 pandemic pandemic NN cord-325324-kh2aal5n 66 15 at at IN cord-325324-kh2aal5n 66 16 a a DT cord-325324-kh2aal5n 66 17 similar similar JJ cord-325324-kh2aal5n 66 18 or or CC cord-325324-kh2aal5n 66 19 even even RB cord-325324-kh2aal5n 66 20 a a DT cord-325324-kh2aal5n 66 21 larger large JJR cord-325324-kh2aal5n 66 22 scale scale NN cord-325324-kh2aal5n 66 23 ( ( -LRB- cord-325324-kh2aal5n 66 24 29 29 CD cord-325324-kh2aal5n 66 25 ) ) -RRB- cord-325324-kh2aal5n 66 26 . . . cord-325324-kh2aal5n 67 1 Although although IN cord-325324-kh2aal5n 67 2 the the DT cord-325324-kh2aal5n 67 3 final final JJ cord-325324-kh2aal5n 67 4 fatality fatality NN cord-325324-kh2aal5n 67 5 rate rate NN cord-325324-kh2aal5n 67 6 is be VBZ cord-325324-kh2aal5n 67 7 the the DT cord-325324-kh2aal5n 67 8 most most RBS cord-325324-kh2aal5n 67 9 accurate accurate JJ cord-325324-kh2aal5n 67 10 and and CC cord-325324-kh2aal5n 67 11 can can MD cord-325324-kh2aal5n 67 12 only only RB cord-325324-kh2aal5n 67 13 be be VB cord-325324-kh2aal5n 67 14 obtained obtain VBN cord-325324-kh2aal5n 67 15 when when WRB cord-325324-kh2aal5n 67 16 the the DT cord-325324-kh2aal5n 67 17 pandemic pandemic NN cord-325324-kh2aal5n 67 18 is be VBZ cord-325324-kh2aal5n 67 19 over over RB cord-325324-kh2aal5n 67 20 , , , cord-325324-kh2aal5n 67 21 the the DT cord-325324-kh2aal5n 67 22 current current JJ cord-325324-kh2aal5n 67 23 data data NN cord-325324-kh2aal5n 67 24 shows show VBZ cord-325324-kh2aal5n 67 25 that that IN cord-325324-kh2aal5n 67 26 it -PRON- PRP cord-325324-kh2aal5n 67 27 could could MD cord-325324-kh2aal5n 67 28 be be VB cord-325324-kh2aal5n 67 29 very very RB cord-325324-kh2aal5n 67 30 high high JJ cord-325324-kh2aal5n 67 31 in in IN cord-325324-kh2aal5n 67 32 some some DT cord-325324-kh2aal5n 67 33 countries country NNS cord-325324-kh2aal5n 67 34 . . . cord-325324-kh2aal5n 68 1 Interestingly interestingly RB cord-325324-kh2aal5n 68 2 , , , cord-325324-kh2aal5n 68 3 the the DT cord-325324-kh2aal5n 68 4 fatality fatality NN cord-325324-kh2aal5n 68 5 by by IN cord-325324-kh2aal5n 68 6 COVID-19 COVID-19 NNP cord-325324-kh2aal5n 68 7 clearly clearly RB cord-325324-kh2aal5n 68 8 correlates correlate VBZ cord-325324-kh2aal5n 68 9 with with IN cord-325324-kh2aal5n 68 10 whether whether IN cord-325324-kh2aal5n 68 11 the the DT cord-325324-kh2aal5n 68 12 patients patient NNS cord-325324-kh2aal5n 68 13 have have VBP cord-325324-kh2aal5n 68 14 one one CD cord-325324-kh2aal5n 68 15 or or CC cord-325324-kh2aal5n 68 16 more more JJR cord-325324-kh2aal5n 68 17 underlying underlying JJ cord-325324-kh2aal5n 68 18 diseases disease NNS cord-325324-kh2aal5n 68 19 . . . cord-325324-kh2aal5n 69 1 The the DT cord-325324-kh2aal5n 69 2 CDC CDC NNP cord-325324-kh2aal5n 69 3 webpage webpage NN cord-325324-kh2aal5n 69 4 have have VBP cord-325324-kh2aal5n 69 5 listed list VBN cord-325324-kh2aal5n 69 6 10 10 CD cord-325324-kh2aal5n 69 7 high high JJ cord-325324-kh2aal5n 69 8 - - HYPH cord-325324-kh2aal5n 69 9 risk risk NN cord-325324-kh2aal5n 69 10 underlying underlie VBG cord-325324-kh2aal5n 69 11 diseases disease NNS cord-325324-kh2aal5n 69 12 ; ; : cord-325324-kh2aal5n 69 13 the the DT cord-325324-kh2aal5n 69 14 top top JJ cord-325324-kh2aal5n 69 15 comorbidities comorbiditie NNS cord-325324-kh2aal5n 69 16 include include VBP cord-325324-kh2aal5n 69 17 hypertension hypertension NN cord-325324-kh2aal5n 69 18 and and CC cord-325324-kh2aal5n 69 19 cardiovascular cardiovascular JJ cord-325324-kh2aal5n 69 20 diseases disease NNS cord-325324-kh2aal5n 69 21 ( ( -LRB- cord-325324-kh2aal5n 69 22 CVDs CVDs NNP cord-325324-kh2aal5n 69 23 ) ) -RRB- cord-325324-kh2aal5n 69 24 ( ( -LRB- cord-325324-kh2aal5n 69 25 30 30 CD cord-325324-kh2aal5n 69 26 ) ) -RRB- cord-325324-kh2aal5n 69 27 ( ( -LRB- cord-325324-kh2aal5n 69 28 31 31 CD cord-325324-kh2aal5n 69 29 ) ) -RRB- cord-325324-kh2aal5n 69 30 ( ( -LRB- cord-325324-kh2aal5n 69 31 32 32 CD cord-325324-kh2aal5n 69 32 ) ) -RRB- cord-325324-kh2aal5n 69 33 ( ( -LRB- cord-325324-kh2aal5n 69 34 33 33 CD cord-325324-kh2aal5n 69 35 ) ) -RRB- cord-325324-kh2aal5n 69 36 and and CC cord-325324-kh2aal5n 69 37 occur occur VBP cord-325324-kh2aal5n 69 38 at at IN cord-325324-kh2aal5n 69 39 significantly significantly RB cord-325324-kh2aal5n 69 40 higher high JJR cord-325324-kh2aal5n 69 41 rates rate NNS cord-325324-kh2aal5n 69 42 in in IN cord-325324-kh2aal5n 69 43 the the DT cord-325324-kh2aal5n 69 44 African african JJ cord-325324-kh2aal5n 69 45 American american JJ cord-325324-kh2aal5n 69 46 and and CC cord-325324-kh2aal5n 69 47 nonwhite nonwhite JJ cord-325324-kh2aal5n 69 48 Hispanic hispanic JJ cord-325324-kh2aal5n 69 49 groups group NNS cord-325324-kh2aal5n 69 50 in in IN cord-325324-kh2aal5n 69 51 the the DT cord-325324-kh2aal5n 69 52 USA USA NNP cord-325324-kh2aal5n 69 53 ( ( -LRB- cord-325324-kh2aal5n 69 54 34 34 CD cord-325324-kh2aal5n 69 55 ) ) -RRB- cord-325324-kh2aal5n 69 56 . . . cord-325324-kh2aal5n 70 1 The the DT cord-325324-kh2aal5n 70 2 abovementioned abovementioned JJ cord-325324-kh2aal5n 70 3 comorbidities comorbiditie NNS cord-325324-kh2aal5n 70 4 of of IN cord-325324-kh2aal5n 70 5 COVID-19 COVID-19 NNP cord-325324-kh2aal5n 70 6 , , , cord-325324-kh2aal5n 70 7 hypertension hypertension NN cord-325324-kh2aal5n 70 8 , , , cord-325324-kh2aal5n 70 9 DM DM NNP cord-325324-kh2aal5n 70 10 and and CC cord-325324-kh2aal5n 70 11 CVDs cvd NNS cord-325324-kh2aal5n 70 12 , , , cord-325324-kh2aal5n 70 13 are be VBP cord-325324-kh2aal5n 70 14 closely closely RB cord-325324-kh2aal5n 70 15 associated associate VBN cord-325324-kh2aal5n 70 16 with with IN cord-325324-kh2aal5n 70 17 RAS RAS NNP cord-325324-kh2aal5n 70 18 signaling signaling NN cord-325324-kh2aal5n 70 19 . . . cord-325324-kh2aal5n 71 1 Angiotensin angiotensin NN cord-325324-kh2aal5n 71 2 I -PRON- PRP cord-325324-kh2aal5n 71 3 is be VBZ cord-325324-kh2aal5n 71 4 generated generate VBN cord-325324-kh2aal5n 71 5 from from IN cord-325324-kh2aal5n 71 6 angiotensinogen angiotensinogen NNP cord-325324-kh2aal5n 71 7 by by IN cord-325324-kh2aal5n 71 8 renin renin NN cord-325324-kh2aal5n 71 9 after after IN cord-325324-kh2aal5n 71 10 being be VBG cord-325324-kh2aal5n 71 11 stimulated stimulate VBN cord-325324-kh2aal5n 71 12 by by IN cord-325324-kh2aal5n 71 13 several several JJ cord-325324-kh2aal5n 71 14 conditions condition NNS cord-325324-kh2aal5n 71 15 such such JJ cord-325324-kh2aal5n 71 16 as as IN cord-325324-kh2aal5n 71 17 low low JJ cord-325324-kh2aal5n 71 18 blood blood NN cord-325324-kh2aal5n 71 19 pressure pressure NN cord-325324-kh2aal5n 71 20 , , , cord-325324-kh2aal5n 71 21 bleeding bleeding NN cord-325324-kh2aal5n 71 22 and and CC cord-325324-kh2aal5n 71 23 dehydration dehydration NN cord-325324-kh2aal5n 71 24 ( ( -LRB- cord-325324-kh2aal5n 71 25 35 35 CD cord-325324-kh2aal5n 71 26 ) ) -RRB- cord-325324-kh2aal5n 71 27 ( ( -LRB- cord-325324-kh2aal5n 71 28 36 36 CD cord-325324-kh2aal5n 71 29 ) ) -RRB- cord-325324-kh2aal5n 71 30 ( ( -LRB- cord-325324-kh2aal5n 71 31 37 37 CD cord-325324-kh2aal5n 71 32 ) ) -RRB- cord-325324-kh2aal5n 71 33 ( ( -LRB- cord-325324-kh2aal5n 71 34 38 38 CD cord-325324-kh2aal5n 71 35 ) ) -RRB- cord-325324-kh2aal5n 71 36 . . . cord-325324-kh2aal5n 72 1 Angiotensin angiotensin NN cord-325324-kh2aal5n 72 2 I -PRON- PRP cord-325324-kh2aal5n 72 3 is be VBZ cord-325324-kh2aal5n 72 4 then then RB cord-325324-kh2aal5n 72 5 converted convert VBN cord-325324-kh2aal5n 72 6 to to IN cord-325324-kh2aal5n 72 7 angiotensin angiotensin NN cord-325324-kh2aal5n 72 8 II II NNP cord-325324-kh2aal5n 72 9 by by IN cord-325324-kh2aal5n 72 10 angiotensin angiotensin NN cord-325324-kh2aal5n 72 11 converting convert VBG cord-325324-kh2aal5n 72 12 enzyme enzyme NN cord-325324-kh2aal5n 72 13 ( ( -LRB- cord-325324-kh2aal5n 72 14 ACE ace NN cord-325324-kh2aal5n 72 15 ) ) -RRB- cord-325324-kh2aal5n 72 16 ( ( -LRB- cord-325324-kh2aal5n 72 17 39 39 CD cord-325324-kh2aal5n 72 18 , , , cord-325324-kh2aal5n 72 19 40 40 CD cord-325324-kh2aal5n 72 20 ) ) -RRB- cord-325324-kh2aal5n 72 21 . . . cord-325324-kh2aal5n 73 1 Angiotensin angiotensin NN cord-325324-kh2aal5n 73 2 II II NNP cord-325324-kh2aal5n 73 3 constricts constrict VBZ cord-325324-kh2aal5n 73 4 vasculature vasculature NN cord-325324-kh2aal5n 73 5 to to TO cord-325324-kh2aal5n 73 6 elevate elevate VB cord-325324-kh2aal5n 73 7 the the DT cord-325324-kh2aal5n 73 8 blood blood NN cord-325324-kh2aal5n 73 9 pressure pressure NN cord-325324-kh2aal5n 73 10 . . . cord-325324-kh2aal5n 74 1 Therefore therefore RB cord-325324-kh2aal5n 74 2 , , , cord-325324-kh2aal5n 74 3 abnormally abnormally RB cord-325324-kh2aal5n 74 4 high high JJ cord-325324-kh2aal5n 74 5 levels level NNS cord-325324-kh2aal5n 74 6 of of IN cord-325324-kh2aal5n 74 7 angiotensin angiotensin NN cord-325324-kh2aal5n 74 8 II ii CD cord-325324-kh2aal5n 74 9 cause cause NN cord-325324-kh2aal5n 74 10 hypertension hypertension NN cord-325324-kh2aal5n 74 11 and and CC cord-325324-kh2aal5n 74 12 also also RB cord-325324-kh2aal5n 74 13 aggravate aggravate VB cord-325324-kh2aal5n 74 14 DM dm NN cord-325324-kh2aal5n 74 15 sequelae sequela NNS cord-325324-kh2aal5n 74 16 and and CC cord-325324-kh2aal5n 74 17 induce induce VB cord-325324-kh2aal5n 74 18 CVDs cvd NNS cord-325324-kh2aal5n 74 19 as as IN cord-325324-kh2aal5n 74 20 shown show VBN cord-325324-kh2aal5n 74 21 in in IN cord-325324-kh2aal5n 74 22 Fig Fig NNP cord-325324-kh2aal5n 74 23 . . . cord-325324-kh2aal5n 75 1 1 1 CD cord-325324-kh2aal5n 75 2 _SP cord-325324-kh2aal5n 75 3 have have VBP cord-325324-kh2aal5n 75 4 been be VBN cord-325324-kh2aal5n 75 5 clinically clinically RB cord-325324-kh2aal5n 75 6 used use VBN cord-325324-kh2aal5n 75 7 to to TO cord-325324-kh2aal5n 75 8 treat treat VB cord-325324-kh2aal5n 75 9 the the DT cord-325324-kh2aal5n 75 10 relevant relevant JJ cord-325324-kh2aal5n 75 11 diseases disease NNS cord-325324-kh2aal5n 75 12 . . . cord-325324-kh2aal5n 76 1 Angiotensin angiotensin NN cord-325324-kh2aal5n 76 2 II II NNP cord-325324-kh2aal5n 76 3 can can MD cord-325324-kh2aal5n 76 4 be be VB cord-325324-kh2aal5n 76 5 subsequently subsequently RB cord-325324-kh2aal5n 76 6 hydrolyzed hydrolyze VBN cord-325324-kh2aal5n 76 7 by by IN cord-325324-kh2aal5n 76 8 ACE2 ACE2 NNP cord-325324-kh2aal5n 76 9 to to TO cord-325324-kh2aal5n 76 10 generate generate VB cord-325324-kh2aal5n 76 11 angiotensin angiotensin NN cord-325324-kh2aal5n 76 12 peptides peptide NNS cord-325324-kh2aal5n 76 13 , , , cord-325324-kh2aal5n 76 14 mainly mainly RB cord-325324-kh2aal5n 76 15 Angiotensin-(1 Angiotensin-(1 NNP cord-325324-kh2aal5n 76 16 - - HYPH cord-325324-kh2aal5n 76 17 7 7 CD cord-325324-kh2aal5n 76 18 ) ) -RRB- cord-325324-kh2aal5n 76 19 , , , cord-325324-kh2aal5n 76 20 also also RB cord-325324-kh2aal5n 76 21 called call VBN cord-325324-kh2aal5n 76 22 Ang- Ang- NNP cord-325324-kh2aal5n 76 23 is be VBZ cord-325324-kh2aal5n 76 24 a a DT cord-325324-kh2aal5n 76 25 vascular vascular JJ cord-325324-kh2aal5n 76 26 dilator dilator NN cord-325324-kh2aal5n 76 27 and and CC cord-325324-kh2aal5n 76 28 hence hence RB cord-325324-kh2aal5n 76 29 reduces reduce VBZ cord-325324-kh2aal5n 76 30 blood blood NN cord-325324-kh2aal5n 76 31 pressure pressure NN cord-325324-kh2aal5n 76 32 ( ( -LRB- cord-325324-kh2aal5n 76 33 See see VB cord-325324-kh2aal5n 76 34 Fig Fig NNP cord-325324-kh2aal5n 76 35 . . NNP cord-325324-kh2aal5n 76 36 1 1 CD cord-325324-kh2aal5n 76 37 ) ) -RRB- cord-325324-kh2aal5n 76 38 . . . cord-325324-kh2aal5n 77 1 ACE ACE NNP cord-325324-kh2aal5n 77 2 II II NNP cord-325324-kh2aal5n 77 3 also also RB cord-325324-kh2aal5n 77 4 hydrolyzes hydrolyze VBZ cord-325324-kh2aal5n 77 5 the the DT cord-325324-kh2aal5n 77 6 angiotensin angiotensin NN cord-325324-kh2aal5n 77 7 I -PRON- PRP cord-325324-kh2aal5n 77 8 to to IN cord-325324-kh2aal5n 77 9 other other JJ cord-325324-kh2aal5n 77 10 peptide peptide NN cord-325324-kh2aal5n 77 11 angiotensin angiotensin NN cord-325324-kh2aal5n 77 12 such such JJ cord-325324-kh2aal5n 77 13 as as IN cord-325324-kh2aal5n 77 14 Angiotensin-(1 Angiotensin-(1 NNP cord-325324-kh2aal5n 77 15 - - HYPH cord-325324-kh2aal5n 77 16 9 9 CD cord-325324-kh2aal5n 77 17 ) ) -RRB- cord-325324-kh2aal5n 77 18 that that WDT cord-325324-kh2aal5n 77 19 is be VBZ cord-325324-kh2aal5n 77 20 another another DT cord-325324-kh2aal5n 77 21 vascular vascular JJ cord-325324-kh2aal5n 77 22 dilator dilator NN cord-325324-kh2aal5n 77 23 ( ( -LRB- cord-325324-kh2aal5n 77 24 42 42 CD cord-325324-kh2aal5n 77 25 ) ) -RRB- cord-325324-kh2aal5n 77 26 ( ( -LRB- cord-325324-kh2aal5n 77 27 43 43 CD cord-325324-kh2aal5n 77 28 ) ) -RRB- cord-325324-kh2aal5n 77 29 ( ( -LRB- cord-325324-kh2aal5n 77 30 44 44 CD cord-325324-kh2aal5n 77 31 ) ) -RRB- cord-325324-kh2aal5n 77 32 . . . cord-325324-kh2aal5n 78 1 Therefore therefore RB cord-325324-kh2aal5n 78 2 , , , cord-325324-kh2aal5n 78 3 the the DT cord-325324-kh2aal5n 78 4 RAS RAS NNP cord-325324-kh2aal5n 78 5 signaling signaling NN cord-325324-kh2aal5n 78 6 is be VBZ cord-325324-kh2aal5n 78 7 a a DT cord-325324-kh2aal5n 78 8 balanced balanced JJ cord-325324-kh2aal5n 78 9 system system NN cord-325324-kh2aal5n 78 10 that that WDT cord-325324-kh2aal5n 78 11 must must MD cord-325324-kh2aal5n 78 12 be be VB cord-325324-kh2aal5n 78 13 maintained maintain VBN cord-325324-kh2aal5n 78 14 for for IN cord-325324-kh2aal5n 78 15 the the DT cord-325324-kh2aal5n 78 16 healthy healthy JJ cord-325324-kh2aal5n 78 17 cardiovascular cardiovascular JJ cord-325324-kh2aal5n 78 18 system system NN cord-325324-kh2aal5n 78 19 with with IN cord-325324-kh2aal5n 78 20 normal normal JJ cord-325324-kh2aal5n 78 21 blood blood NN cord-325324-kh2aal5n 78 22 pressure pressure NN cord-325324-kh2aal5n 78 23 and and CC cord-325324-kh2aal5n 78 24 normal normal JJ cord-325324-kh2aal5n 78 25 cardiovascular cardiovascular JJ cord-325324-kh2aal5n 78 26 function function NN cord-325324-kh2aal5n 78 27 . . . cord-325324-kh2aal5n 79 1 A a DT cord-325324-kh2aal5n 79 2 theory theory NN cord-325324-kh2aal5n 79 3 for for IN cord-325324-kh2aal5n 79 4 explaining explain VBG cord-325324-kh2aal5n 79 5 how how WRB cord-325324-kh2aal5n 79 6 the the DT cord-325324-kh2aal5n 79 7 aforementioned aforementioned JJ cord-325324-kh2aal5n 79 8 comorbidities comorbiditie NNS cord-325324-kh2aal5n 79 9 significantly significantly RB cord-325324-kh2aal5n 79 10 increase increase VBP cord-325324-kh2aal5n 79 11 the the DT cord-325324-kh2aal5n 79 12 fatality fatality NN cord-325324-kh2aal5n 79 13 of of IN cord-325324-kh2aal5n 79 14 COVID-19 COVID-19 NNP cord-325324-kh2aal5n 79 15 was be VBD cord-325324-kh2aal5n 79 16 based base VBN cord-325324-kh2aal5n 79 17 on on IN cord-325324-kh2aal5n 79 18 the the DT cord-325324-kh2aal5n 79 19 fact fact NN cord-325324-kh2aal5n 79 20 that that IN cord-325324-kh2aal5n 79 21 these these DT cord-325324-kh2aal5n 79 22 patients patient NNS cord-325324-kh2aal5n 79 23 have have VBP cord-325324-kh2aal5n 79 24 a a DT cord-325324-kh2aal5n 79 25 history history NN cord-325324-kh2aal5n 79 26 of of IN cord-325324-kh2aal5n 79 27 taking take VBG cord-325324-kh2aal5n 79 28 drugs drug NNS cord-325324-kh2aal5n 79 29 such such JJ cord-325324-kh2aal5n 79 30 as as IN cord-325324-kh2aal5n 79 31 ACEIs acei NNS cord-325324-kh2aal5n 79 32 , , , cord-325324-kh2aal5n 79 33 ARBs arb NNS cord-325324-kh2aal5n 79 34 and and CC cord-325324-kh2aal5n 79 35 ibuprofen ibuprofen NN cord-325324-kh2aal5n 79 36 ( ( -LRB- cord-325324-kh2aal5n 79 37 45 45 CD cord-325324-kh2aal5n 79 38 , , , cord-325324-kh2aal5n 79 39 46 46 CD cord-325324-kh2aal5n 79 40 ) ) -RRB- cord-325324-kh2aal5n 79 41 . . . cord-325324-kh2aal5n 80 1 These these DT cord-325324-kh2aal5n 80 2 drugs drug NNS cord-325324-kh2aal5n 80 3 not not RB cord-325324-kh2aal5n 80 4 only only RB cord-325324-kh2aal5n 80 5 inhibit inhibit VB cord-325324-kh2aal5n 80 6 ACE ace NN cord-325324-kh2aal5n 80 7 but but CC cord-325324-kh2aal5n 80 8 increase increase VB cord-325324-kh2aal5n 80 9 the the DT cord-325324-kh2aal5n 80 10 level level NN cord-325324-kh2aal5n 80 11 of of IN cord-325324-kh2aal5n 80 12 ACE2 ACE2 NNP cord-325324-kh2aal5n 80 13 as as RB cord-325324-kh2aal5n 80 14 well well RB cord-325324-kh2aal5n 80 15 . . . cord-325324-kh2aal5n 81 1 The the DT cord-325324-kh2aal5n 81 2 increase increase NN cord-325324-kh2aal5n 81 3 of of IN cord-325324-kh2aal5n 81 4 ACE2 ACE2 NNP cord-325324-kh2aal5n 81 5 might may MD cord-325324-kh2aal5n 81 6 elevate elevate VB cord-325324-kh2aal5n 81 7 the the DT cord-325324-kh2aal5n 81 8 chances chance NNS cord-325324-kh2aal5n 81 9 of of IN cord-325324-kh2aal5n 81 10 infection infection NN cord-325324-kh2aal5n 81 11 of of IN cord-325324-kh2aal5n 81 12 SARS SARS NNP cord-325324-kh2aal5n 81 13 - - HYPH cord-325324-kh2aal5n 81 14 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 81 15 , , , cord-325324-kh2aal5n 81 16 which which WDT cord-325324-kh2aal5n 81 17 directly directly RB cord-325324-kh2aal5n 81 18 relates relate VBZ cord-325324-kh2aal5n 81 19 to to IN cord-325324-kh2aal5n 81 20 the the DT cord-325324-kh2aal5n 81 21 viral viral JJ cord-325324-kh2aal5n 81 22 infection infection NN cord-325324-kh2aal5n 81 23 and and CC cord-325324-kh2aal5n 81 24 fatality fatality NN cord-325324-kh2aal5n 81 25 . . . cord-325324-kh2aal5n 82 1 This this DT cord-325324-kh2aal5n 82 2 theory theory NN cord-325324-kh2aal5n 82 3 is be VBZ cord-325324-kh2aal5n 82 4 shown show VBN cord-325324-kh2aal5n 82 5 in in IN cord-325324-kh2aal5n 82 6 the the DT cord-325324-kh2aal5n 82 7 left left JJ cord-325324-kh2aal5n 82 8 side side NN cord-325324-kh2aal5n 82 9 of of IN cord-325324-kh2aal5n 82 10 Fig Fig NNP cord-325324-kh2aal5n 82 11 . . . cord-325324-kh2aal5n 83 1 1 1 CD cord-325324-kh2aal5n 83 2 as as IN cord-325324-kh2aal5n 83 3 " " `` cord-325324-kh2aal5n 83 4 ACE2 ACE2 NNP cord-325324-kh2aal5n 83 5 enhancing enhance VBG cord-325324-kh2aal5n 83 6 viral viral JJ cord-325324-kh2aal5n 83 7 infection infection NN cord-325324-kh2aal5n 83 8 " " '' cord-325324-kh2aal5n 83 9 ( ( -LRB- cord-325324-kh2aal5n 83 10 45 45 CD cord-325324-kh2aal5n 83 11 , , , cord-325324-kh2aal5n 83 12 46 46 CD cord-325324-kh2aal5n 83 13 ) ) -RRB- cord-325324-kh2aal5n 83 14 . . . cord-325324-kh2aal5n 84 1 However however RB cord-325324-kh2aal5n 84 2 , , , cord-325324-kh2aal5n 84 3 this this DT cord-325324-kh2aal5n 84 4 theory theory NN cord-325324-kh2aal5n 84 5 does do VBZ cord-325324-kh2aal5n 84 6 not not RB cord-325324-kh2aal5n 84 7 explain explain VB cord-325324-kh2aal5n 84 8 why why WRB cord-325324-kh2aal5n 84 9 the the DT cord-325324-kh2aal5n 84 10 onset onset NN cord-325324-kh2aal5n 84 11 of of IN cord-325324-kh2aal5n 84 12 COVID-19 covid-19 NN cord-325324-kh2aal5n 84 13 in in IN cord-325324-kh2aal5n 84 14 these these DT cord-325324-kh2aal5n 84 15 patients patient NNS cord-325324-kh2aal5n 84 16 is be VBZ cord-325324-kh2aal5n 84 17 so so RB cord-325324-kh2aal5n 84 18 rapid rapid JJ cord-325324-kh2aal5n 84 19 that that IN cord-325324-kh2aal5n 84 20 an an DT cord-325324-kh2aal5n 84 21 emergent emergent JJ cord-325324-kh2aal5n 84 22 rescue rescue NN cord-325324-kh2aal5n 84 23 is be VBZ cord-325324-kh2aal5n 84 24 needed need VBN cord-325324-kh2aal5n 84 25 and and CC cord-325324-kh2aal5n 84 26 many many JJ cord-325324-kh2aal5n 84 27 of of IN cord-325324-kh2aal5n 84 28 them -PRON- PRP cord-325324-kh2aal5n 84 29 still still RB cord-325324-kh2aal5n 84 30 die die VBP cord-325324-kh2aal5n 84 31 . . . cord-325324-kh2aal5n 85 1 Furthermore furthermore RB cord-325324-kh2aal5n 85 2 , , , cord-325324-kh2aal5n 85 3 it -PRON- PRP cord-325324-kh2aal5n 85 4 contradicts contradict VBZ cord-325324-kh2aal5n 85 5 the the DT cord-325324-kh2aal5n 85 6 recently recently RB cord-325324-kh2aal5n 85 7 published publish VBN cord-325324-kh2aal5n 85 8 reports report NNS cord-325324-kh2aal5n 85 9 that that IN cord-325324-kh2aal5n 85 10 using use VBG cord-325324-kh2aal5n 85 11 ARBs arb NNS cord-325324-kh2aal5n 85 12 and and CC cord-325324-kh2aal5n 85 13 ACEIs acei NNS cord-325324-kh2aal5n 85 14 improved improve VBN cord-325324-kh2aal5n 85 15 COVID-19 COVID-19 NNP cord-325324-kh2aal5n 85 16 ( ( -LRB- cord-325324-kh2aal5n 85 17 47 47 CD cord-325324-kh2aal5n 85 18 ) ) -RRB- cord-325324-kh2aal5n 85 19 ( ( -LRB- cord-325324-kh2aal5n 85 20 48 48 CD cord-325324-kh2aal5n 85 21 ) ) -RRB- cord-325324-kh2aal5n 85 22 ( ( -LRB- cord-325324-kh2aal5n 85 23 49 49 CD cord-325324-kh2aal5n 85 24 ) ) -RRB- cord-325324-kh2aal5n 85 25 . . . cord-325324-kh2aal5n 86 1 Some some DT cord-325324-kh2aal5n 86 2 critical critical JJ cord-325324-kh2aal5n 86 3 reviews review NNS cord-325324-kh2aal5n 86 4 analyzed analyze VBD cord-325324-kh2aal5n 86 5 the the DT cord-325324-kh2aal5n 86 6 available available JJ cord-325324-kh2aal5n 86 7 evidence evidence NN cord-325324-kh2aal5n 86 8 and and CC cord-325324-kh2aal5n 86 9 found find VBD cord-325324-kh2aal5n 86 10 that that IN cord-325324-kh2aal5n 86 11 it -PRON- PRP cord-325324-kh2aal5n 86 12 does do VBZ cord-325324-kh2aal5n 86 13 not not RB cord-325324-kh2aal5n 86 14 support support VB cord-325324-kh2aal5n 86 15 a a DT cord-325324-kh2aal5n 86 16 deleterious deleterious JJ cord-325324-kh2aal5n 86 17 effect effect NN cord-325324-kh2aal5n 86 18 of of IN cord-325324-kh2aal5n 86 19 RAS RAS NNP cord-325324-kh2aal5n 86 20 blockers blocker NNS cord-325324-kh2aal5n 86 21 in in IN cord-325324-kh2aal5n 86 22 COVID-19 COVID-19 NNP cord-325324-kh2aal5n 86 23 ( ( -LRB- cord-325324-kh2aal5n 86 24 50 50 CD cord-325324-kh2aal5n 86 25 ) ) -RRB- cord-325324-kh2aal5n 86 26 ( ( -LRB- cord-325324-kh2aal5n 86 27 51 51 CD cord-325324-kh2aal5n 86 28 ) ) -RRB- cord-325324-kh2aal5n 86 29 ( ( -LRB- cord-325324-kh2aal5n 86 30 52 52 CD cord-325324-kh2aal5n 86 31 ) ) -RRB- cord-325324-kh2aal5n 86 32 . . . cord-325324-kh2aal5n 87 1 Therefore therefore RB cord-325324-kh2aal5n 87 2 , , , cord-325324-kh2aal5n 87 3 it -PRON- PRP cord-325324-kh2aal5n 87 4 is be VBZ cord-325324-kh2aal5n 87 5 suggested suggest VBN cord-325324-kh2aal5n 87 6 that that IN cord-325324-kh2aal5n 87 7 there there EX cord-325324-kh2aal5n 87 8 is be VBZ cord-325324-kh2aal5n 87 9 currently currently RB cord-325324-kh2aal5n 87 10 no no DT cord-325324-kh2aal5n 87 11 reason reason NN cord-325324-kh2aal5n 87 12 to to TO cord-325324-kh2aal5n 87 13 discontinue discontinue VB cord-325324-kh2aal5n 87 14 RAS RAS NNP cord-325324-kh2aal5n 87 15 blocking blocking NN cord-325324-kh2aal5n 87 16 ACEIs acei NNS cord-325324-kh2aal5n 87 17 in in IN cord-325324-kh2aal5n 87 18 stable stable JJ cord-325324-kh2aal5n 87 19 patients patient NNS cord-325324-kh2aal5n 87 20 who who WP cord-325324-kh2aal5n 87 21 suffer suffer VBP cord-325324-kh2aal5n 87 22 from from IN cord-325324-kh2aal5n 87 23 the the DT cord-325324-kh2aal5n 87 24 COVID-19 COVID-19 NNP cord-325324-kh2aal5n 87 25 ( ( -LRB- cord-325324-kh2aal5n 87 26 50 50 CD cord-325324-kh2aal5n 87 27 ) ) -RRB- cord-325324-kh2aal5n 87 28 . . . cord-325324-kh2aal5n 88 1 ACE2 ACE2 NNP cord-325324-kh2aal5n 88 2 is be VBZ cord-325324-kh2aal5n 88 3 a a DT cord-325324-kh2aal5n 88 4 cell cell NN cord-325324-kh2aal5n 88 5 membrane membrane NN cord-325324-kh2aal5n 88 6 protein protein NN cord-325324-kh2aal5n 88 7 in in IN cord-325324-kh2aal5n 88 8 lungs lung NNS cord-325324-kh2aal5n 88 9 , , , cord-325324-kh2aal5n 88 10 arteries artery NNS cord-325324-kh2aal5n 88 11 , , , cord-325324-kh2aal5n 88 12 heart heart NN cord-325324-kh2aal5n 88 13 , , , cord-325324-kh2aal5n 88 14 kidney kidney NN cord-325324-kh2aal5n 88 15 and and CC cord-325324-kh2aal5n 88 16 intestines intestine NNS cord-325324-kh2aal5n 88 17 ( ( -LRB- cord-325324-kh2aal5n 88 18 53 53 CD cord-325324-kh2aal5n 88 19 ) ) -RRB- cord-325324-kh2aal5n 89 1 ( ( -LRB- cord-325324-kh2aal5n 89 2 54 54 CD cord-325324-kh2aal5n 89 3 ) ) -RRB- cord-325324-kh2aal5n 90 1 ( ( -LRB- cord-325324-kh2aal5n 90 2 55 55 CD cord-325324-kh2aal5n 90 3 ) ) -RRB- cord-325324-kh2aal5n 90 4 . . . cord-325324-kh2aal5n 91 1 ACE2 ACE2 NNP cord-325324-kh2aal5n 91 2 converts convert VBZ cord-325324-kh2aal5n 91 3 angiotensin angiotensin NN cord-325324-kh2aal5n 91 4 II II NNP cord-325324-kh2aal5n 91 5 to to TO cord-325324-kh2aal5n 91 6 peptide peptide NN cord-325324-kh2aal5n 91 7 Ang-(1 Ang-(1 NNP cord-325324-kh2aal5n 91 8 - - HYPH cord-325324-kh2aal5n 91 9 7 7 CD cord-325324-kh2aal5n 91 10 ) ) -RRB- cord-325324-kh2aal5n 92 1 or or CC cord-325324-kh2aal5n 92 2 angiotensin angiotensin NN cord-325324-kh2aal5n 92 3 I -PRON- PRP cord-325324-kh2aal5n 92 4 to to TO cord-325324-kh2aal5n 92 5 peptide peptide VB cord-325324-kh2aal5n 92 6 Ang-(1 Ang-(1 NNP cord-325324-kh2aal5n 92 7 - - HYPH cord-325324-kh2aal5n 92 8 9 9 CD cord-325324-kh2aal5n 92 9 ) ) -RRB- cord-325324-kh2aal5n 92 10 ; ; : cord-325324-kh2aal5n 92 11 both both DT cord-325324-kh2aal5n 92 12 peptides peptide NNS cord-325324-kh2aal5n 92 13 are be VBP cord-325324-kh2aal5n 92 14 vasodilators vasodilator NNS cord-325324-kh2aal5n 92 15 ( ( -LRB- cord-325324-kh2aal5n 92 16 35 35 CD cord-325324-kh2aal5n 92 17 , , , cord-325324-kh2aal5n 92 18 41 41 CD cord-325324-kh2aal5n 92 19 , , , cord-325324-kh2aal5n 92 20 ( ( -LRB- cord-325324-kh2aal5n 92 21 56 56 CD cord-325324-kh2aal5n 92 22 ) ) -RRB- cord-325324-kh2aal5n 92 23 ( ( -LRB- cord-325324-kh2aal5n 92 24 57 57 CD cord-325324-kh2aal5n 92 25 ) ) -RRB- cord-325324-kh2aal5n 92 26 ( ( -LRB- cord-325324-kh2aal5n 92 27 58 58 CD cord-325324-kh2aal5n 92 28 ) ) -RRB- cord-325324-kh2aal5n 92 29 . . . cord-325324-kh2aal5n 93 1 Therefore therefore RB cord-325324-kh2aal5n 93 2 , , , cord-325324-kh2aal5n 93 3 ACE2 ACE2 NNP cord-325324-kh2aal5n 93 4 physiologically physiologically RB cord-325324-kh2aal5n 93 5 reduces reduce VBZ cord-325324-kh2aal5n 93 6 blood blood NN cord-325324-kh2aal5n 93 7 pressure pressure NN cord-325324-kh2aal5n 93 8 and and CC cord-325324-kh2aal5n 93 9 is be VBZ cord-325324-kh2aal5n 93 10 anti anti JJ cord-325324-kh2aal5n 93 11 - - JJ cord-325324-kh2aal5n 93 12 hypertensive hypertensive JJ cord-325324-kh2aal5n 93 13 when when WRB cord-325324-kh2aal5n 93 14 the the DT cord-325324-kh2aal5n 93 15 angiotensin angiotensin NN cord-325324-kh2aal5n 93 16 II II NNP cord-325324-kh2aal5n 93 17 is be VBZ cord-325324-kh2aal5n 93 18 elevated elevate VBN cord-325324-kh2aal5n 93 19 . . . cord-325324-kh2aal5n 94 1 SARS SARS NNP cord-325324-kh2aal5n 94 2 - - HYPH cord-325324-kh2aal5n 94 3 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 94 4 spike spike NN cord-325324-kh2aal5n 94 5 protein protein NN cord-325324-kh2aal5n 94 6 ( ( -LRB- cord-325324-kh2aal5n 94 7 S s NN cord-325324-kh2aal5n 94 8 ) ) -RRB- cord-325324-kh2aal5n 94 9 is be VBZ cord-325324-kh2aal5n 94 10 cleaved cleave VBN cord-325324-kh2aal5n 94 11 by by IN cord-325324-kh2aal5n 94 12 the the DT cord-325324-kh2aal5n 94 13 human human JJ cord-325324-kh2aal5n 94 14 furin furin NN cord-325324-kh2aal5n 94 15 enzyme enzyme NN cord-325324-kh2aal5n 94 16 to to TO cord-325324-kh2aal5n 94 17 generate generate VB cord-325324-kh2aal5n 94 18 S1 S1 NNP cord-325324-kh2aal5n 94 19 , , , cord-325324-kh2aal5n 94 20 which which WDT cord-325324-kh2aal5n 94 21 binds bind VBZ cord-325324-kh2aal5n 94 22 to to IN cord-325324-kh2aal5n 94 23 the the DT cord-325324-kh2aal5n 94 24 host host NN cord-325324-kh2aal5n 94 25 receptor receptor NN cord-325324-kh2aal5n 94 26 , , , cord-325324-kh2aal5n 94 27 ACE-2 ACE-2 NNP cord-325324-kh2aal5n 94 28 . . . cord-325324-kh2aal5n 95 1 It -PRON- PRP cord-325324-kh2aal5n 95 2 is be VBZ cord-325324-kh2aal5n 95 3 possible possible JJ cord-325324-kh2aal5n 95 4 that that IN cord-325324-kh2aal5n 95 5 the the DT cord-325324-kh2aal5n 95 6 released release VBN cord-325324-kh2aal5n 95 7 free free JJ cord-325324-kh2aal5n 95 8 spike spike NN cord-325324-kh2aal5n 95 9 or or CC cord-325324-kh2aal5n 95 10 the the DT cord-325324-kh2aal5n 95 11 cleaved cleaved JJ cord-325324-kh2aal5n 95 12 S1 S1 NNP cord-325324-kh2aal5n 95 13 protein protein NN cord-325324-kh2aal5n 95 14 in in IN cord-325324-kh2aal5n 95 15 the the DT cord-325324-kh2aal5n 95 16 blood blood NN cord-325324-kh2aal5n 95 17 might may MD cord-325324-kh2aal5n 95 18 bind bind VB cord-325324-kh2aal5n 95 19 to to IN cord-325324-kh2aal5n 95 20 cellular cellular JJ cord-325324-kh2aal5n 95 21 membrane membrane NN cord-325324-kh2aal5n 95 22 ACE2 ACE2 NNP cord-325324-kh2aal5n 95 23 of of IN cord-325324-kh2aal5n 95 24 heart heart NN cord-325324-kh2aal5n 95 25 , , , cord-325324-kh2aal5n 95 26 artery artery NN cord-325324-kh2aal5n 95 27 and and CC cord-325324-kh2aal5n 95 28 alveolar alveolar NN cord-325324-kh2aal5n 95 29 lung lung NN cord-325324-kh2aal5n 95 30 cells cell NNS cord-325324-kh2aal5n 95 31 to to TO cord-325324-kh2aal5n 95 32 block block VB cord-325324-kh2aal5n 95 33 the the DT cord-325324-kh2aal5n 95 34 conversion conversion NN cord-325324-kh2aal5n 95 35 of of IN cord-325324-kh2aal5n 95 36 Angiotensin Angiotensin NNP cord-325324-kh2aal5n 95 37 II II NNP cord-325324-kh2aal5n 95 38 to to IN cord-325324-kh2aal5n 95 39 Ang-(1 Ang-(1 NNP cord-325324-kh2aal5n 95 40 - - HYPH cord-325324-kh2aal5n 95 41 7 7 CD cord-325324-kh2aal5n 95 42 ) ) -RRB- cord-325324-kh2aal5n 96 1 and/or and/or CC cord-325324-kh2aal5n 97 1 Angiotensin angiotensin NN cord-325324-kh2aal5n 97 2 I -PRON- PRP cord-325324-kh2aal5n 97 3 to to IN cord-325324-kh2aal5n 97 4 Ang-(1 Ang-(1 NNP cord-325324-kh2aal5n 97 5 - - HYPH cord-325324-kh2aal5n 97 6 9 9 CD cord-325324-kh2aal5n 97 7 ) ) -RRB- cord-325324-kh2aal5n 97 8 , , , cord-325324-kh2aal5n 97 9 which which WDT cord-325324-kh2aal5n 97 10 is be VBZ cord-325324-kh2aal5n 97 11 consistent consistent JJ cord-325324-kh2aal5n 97 12 with with IN cord-325324-kh2aal5n 97 13 a a DT cord-325324-kh2aal5n 97 14 previous previous JJ cord-325324-kh2aal5n 97 15 experimental experimental JJ cord-325324-kh2aal5n 97 16 result result NN cord-325324-kh2aal5n 97 17 on on IN cord-325324-kh2aal5n 97 18 SARS SARS NNP cord-325324-kh2aal5n 97 19 - - HYPH cord-325324-kh2aal5n 97 20 CoV-1 CoV-1 NNP cord-325324-kh2aal5n 97 21 ( ( -LRB- cord-325324-kh2aal5n 97 22 59 59 CD cord-325324-kh2aal5n 97 23 ) ) -RRB- cord-325324-kh2aal5n 97 24 . . . cord-325324-kh2aal5n 98 1 The the DT cord-325324-kh2aal5n 98 2 interaction interaction NN cord-325324-kh2aal5n 98 3 with with IN cord-325324-kh2aal5n 98 4 SARS SARS NNP cord-325324-kh2aal5n 98 5 - - HYPH cord-325324-kh2aal5n 98 6 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 98 7 S S NNP cord-325324-kh2aal5n 98 8 protein protein NN cord-325324-kh2aal5n 98 9 might may MD cord-325324-kh2aal5n 98 10 exhaust exhaust VB cord-325324-kh2aal5n 98 11 ACE-2 ACE-2 NNP cord-325324-kh2aal5n 98 12 or or CC cord-325324-kh2aal5n 98 13 damage damage NN cord-325324-kh2aal5n 98 14 ACE-2 ACE-2 NNP cord-325324-kh2aal5n 98 15 function function NN cord-325324-kh2aal5n 98 16 . . . cord-325324-kh2aal5n 99 1 Therefore therefore RB cord-325324-kh2aal5n 99 2 , , , cord-325324-kh2aal5n 99 3 our -PRON- PRP$ cord-325324-kh2aal5n 99 4 hypothesis hypothesis NN cord-325324-kh2aal5n 99 5 , , , cord-325324-kh2aal5n 99 6 as as IN cord-325324-kh2aal5n 99 7 shown show VBN cord-325324-kh2aal5n 99 8 in in IN cord-325324-kh2aal5n 99 9 the the DT cord-325324-kh2aal5n 99 10 right right JJ cord-325324-kh2aal5n 99 11 side side NN cord-325324-kh2aal5n 99 12 of of IN cord-325324-kh2aal5n 99 13 Fig Fig NNP cord-325324-kh2aal5n 99 14 . . . cord-325324-kh2aal5n 99 15 1 1 CD cord-325324-kh2aal5n 99 16 as as IN cord-325324-kh2aal5n 99 17 " " `` cord-325324-kh2aal5n 99 18 Viral viral JJ cord-325324-kh2aal5n 99 19 aggravating aggravate VBG cord-325324-kh2aal5n 99 20 existing exist VBG cord-325324-kh2aal5n 99 21 diseases disease NNS cord-325324-kh2aal5n 99 22 " " '' cord-325324-kh2aal5n 99 23 , , , cord-325324-kh2aal5n 99 24 is be VBZ cord-325324-kh2aal5n 99 25 that that IN cord-325324-kh2aal5n 99 26 comorbidities comorbiditie NNS cord-325324-kh2aal5n 99 27 in in IN cord-325324-kh2aal5n 99 28 COVID-19 covid-19 JJ cord-325324-kh2aal5n 99 29 patients patient NNS cord-325324-kh2aal5n 99 30 are be VBP cord-325324-kh2aal5n 99 31 aggravated aggravate VBN cord-325324-kh2aal5n 99 32 by by IN cord-325324-kh2aal5n 99 33 the the DT cord-325324-kh2aal5n 99 34 infection infection NN cord-325324-kh2aal5n 99 35 of of IN cord-325324-kh2aal5n 99 36 SARS SARS NNP cord-325324-kh2aal5n 99 37 - - HYPH cord-325324-kh2aal5n 99 38 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 99 39 to to TO cord-325324-kh2aal5n 99 40 causes cause VBZ cord-325324-kh2aal5n 99 41 higher high JJR cord-325324-kh2aal5n 99 42 fatalities fatality NNS cord-325324-kh2aal5n 99 43 because because IN cord-325324-kh2aal5n 99 44 the the DT cord-325324-kh2aal5n 99 45 viral viral JJ cord-325324-kh2aal5n 99 46 S S NNP cord-325324-kh2aal5n 99 47 protein protein NN cord-325324-kh2aal5n 99 48 interacts interact VBZ cord-325324-kh2aal5n 99 49 with with IN cord-325324-kh2aal5n 99 50 ACE2 ACE2 NNP cord-325324-kh2aal5n 99 51 to to TO cord-325324-kh2aal5n 99 52 inhibit inhibit VB cord-325324-kh2aal5n 99 53 ACE2 ACE2 NNP cord-325324-kh2aal5n 99 54 function function NN cord-325324-kh2aal5n 99 55 . . . cord-325324-kh2aal5n 100 1 This this DT cord-325324-kh2aal5n 100 2 hypothesis hypothesis NN cord-325324-kh2aal5n 100 3 is be VBZ cord-325324-kh2aal5n 100 4 also also RB cord-325324-kh2aal5n 100 5 supported support VBN cord-325324-kh2aal5n 100 6 by by IN cord-325324-kh2aal5n 100 7 a a DT cord-325324-kh2aal5n 100 8 clinical clinical JJ cord-325324-kh2aal5n 100 9 finding finding NN cord-325324-kh2aal5n 100 10 that that IN cord-325324-kh2aal5n 100 11 an an DT cord-325324-kh2aal5n 100 12 imbalance imbalance NN cord-325324-kh2aal5n 100 13 of of IN cord-325324-kh2aal5n 100 14 the the DT cord-325324-kh2aal5n 100 15 AngII AngII NNP cord-325324-kh2aal5n 100 16 - - HYPH cord-325324-kh2aal5n 100 17 ACE2-Ang-(1 ACE2-Ang-(1 NNP cord-325324-kh2aal5n 100 18 - - HYPH cord-325324-kh2aal5n 100 19 7 7 CD cord-325324-kh2aal5n 100 20 ) ) -RRB- cord-325324-kh2aal5n 100 21 axis axis NN cord-325324-kh2aal5n 100 22 occurs occur VBZ cord-325324-kh2aal5n 100 23 in in IN cord-325324-kh2aal5n 100 24 human human JJ cord-325324-kh2aal5n 100 25 pulmonary pulmonary JJ cord-325324-kh2aal5n 100 26 artery artery NN cord-325324-kh2aal5n 100 27 hypertension hypertension NN cord-325324-kh2aal5n 100 28 ( ( -LRB- cord-325324-kh2aal5n 100 29 PAH PAH NNP cord-325324-kh2aal5n 100 30 ) ) -RRB- cord-325324-kh2aal5n 100 31 , , , cord-325324-kh2aal5n 100 32 with with IN cord-325324-kh2aal5n 100 33 reduced reduce VBN cord-325324-kh2aal5n 100 34 ACE2 ACE2 NNP cord-325324-kh2aal5n 100 35 levels level NNS cord-325324-kh2aal5n 100 36 implicated implicate VBN cord-325324-kh2aal5n 100 37 in in IN cord-325324-kh2aal5n 100 38 the the DT cord-325324-kh2aal5n 100 39 pathogenesis pathogenesis NN cord-325324-kh2aal5n 100 40 of of IN cord-325324-kh2aal5n 100 41 severe severe JJ cord-325324-kh2aal5n 100 42 PAH PAH NNP cord-325324-kh2aal5n 100 43 ( ( -LRB- cord-325324-kh2aal5n 100 44 60 60 CD cord-325324-kh2aal5n 100 45 ) ) -RRB- cord-325324-kh2aal5n 100 46 . . . cord-325324-kh2aal5n 101 1 However however RB cord-325324-kh2aal5n 101 2 , , , cord-325324-kh2aal5n 101 3 an an DT cord-325324-kh2aal5n 101 4 animal animal NN cord-325324-kh2aal5n 101 5 study study NN cord-325324-kh2aal5n 101 6 demonstrated demonstrate VBD cord-325324-kh2aal5n 101 7 that that IN cord-325324-kh2aal5n 101 8 ACE2 ACE2 NNP cord-325324-kh2aal5n 101 9 level level NN cord-325324-kh2aal5n 101 10 in in IN cord-325324-kh2aal5n 101 11 lung lung NN cord-325324-kh2aal5n 101 12 is be VBZ cord-325324-kh2aal5n 101 13 low low JJ cord-325324-kh2aal5n 101 14 and and CC cord-325324-kh2aal5n 101 15 that that IN cord-325324-kh2aal5n 101 16 Prolyloligopeptidase Prolyloligopeptidase NNP cord-325324-kh2aal5n 101 17 ( ( -LRB- cord-325324-kh2aal5n 101 18 POP pop NN cord-325324-kh2aal5n 101 19 ) ) -RRB- cord-325324-kh2aal5n 101 20 is be VBZ cord-325324-kh2aal5n 101 21 the the DT cord-325324-kh2aal5n 101 22 main main JJ cord-325324-kh2aal5n 101 23 enzyme enzyme NN cord-325324-kh2aal5n 101 24 responsible responsible JJ cord-325324-kh2aal5n 101 25 for for IN cord-325324-kh2aal5n 101 26 Ang Ang NNP cord-325324-kh2aal5n 101 27 II II NNP cord-325324-kh2aal5n 101 28 conversion conversion NN cord-325324-kh2aal5n 101 29 to to IN cord-325324-kh2aal5n 101 30 Ang-(1 Ang-(1 NNP cord-325324-kh2aal5n 101 31 - - HYPH cord-325324-kh2aal5n 101 32 7 7 CD cord-325324-kh2aal5n 101 33 ) ) -RRB- cord-325324-kh2aal5n 101 34 in in IN cord-325324-kh2aal5n 101 35 the the DT cord-325324-kh2aal5n 101 36 lungs lung NNS cord-325324-kh2aal5n 101 37 ( ( -LRB- cord-325324-kh2aal5n 101 38 61 61 CD cord-325324-kh2aal5n 101 39 ) ) -RRB- cord-325324-kh2aal5n 101 40 . . . cord-325324-kh2aal5n 102 1 Therefore therefore RB cord-325324-kh2aal5n 102 2 , , , cord-325324-kh2aal5n 102 3 an an DT cord-325324-kh2aal5n 102 4 alternative alternative JJ cord-325324-kh2aal5n 102 5 mechanism mechanism NN cord-325324-kh2aal5n 102 6 might may MD cord-325324-kh2aal5n 102 7 exist exist VB cord-325324-kh2aal5n 102 8 when when WRB cord-325324-kh2aal5n 102 9 ACE2 ACE2 NNP cord-325324-kh2aal5n 102 10 is be VBZ cord-325324-kh2aal5n 102 11 exhausted exhaust VBN cord-325324-kh2aal5n 102 12 in in IN cord-325324-kh2aal5n 102 13 COVID-19 covid-19 JJ cord-325324-kh2aal5n 102 14 patients patient NNS cord-325324-kh2aal5n 102 15 . . . cord-325324-kh2aal5n 103 1 and and CC cord-325324-kh2aal5n 103 2 50 50 CD cord-325324-kh2aal5n 103 3 % % NN cord-325324-kh2aal5n 103 4 , , , cord-325324-kh2aal5n 103 5 respectively respectively RB cord-325324-kh2aal5n 103 6 ( ( -LRB- cord-325324-kh2aal5n 103 7 66 66 CD cord-325324-kh2aal5n 103 8 ) ) -RRB- cord-325324-kh2aal5n 103 9 . . . cord-325324-kh2aal5n 104 1 A a DT cord-325324-kh2aal5n 104 2 novel novel JJ cord-325324-kh2aal5n 104 3 furin furin NN cord-325324-kh2aal5n 104 4 cleavage cleavage NN cord-325324-kh2aal5n 104 5 site site NN cord-325324-kh2aal5n 104 6 was be VBD cord-325324-kh2aal5n 104 7 identified identify VBN cord-325324-kh2aal5n 104 8 at at IN cord-325324-kh2aal5n 104 9 the the DT cord-325324-kh2aal5n 104 10 boundary boundary NN cord-325324-kh2aal5n 104 11 between between IN cord-325324-kh2aal5n 104 12 the the DT cord-325324-kh2aal5n 104 13 S1 S1 NNP cord-325324-kh2aal5n 104 14 / / SYM cord-325324-kh2aal5n 104 15 S2 S2 NNP cord-325324-kh2aal5n 104 16 subunits subunit NNS cord-325324-kh2aal5n 104 17 of of IN cord-325324-kh2aal5n 104 18 SARS SARS NNP cord-325324-kh2aal5n 104 19 - - HYPH cord-325324-kh2aal5n 104 20 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 104 21 but but CC cord-325324-kh2aal5n 104 22 not not RB cord-325324-kh2aal5n 104 23 in in IN cord-325324-kh2aal5n 104 24 SARS SARS NNP cord-325324-kh2aal5n 104 25 - - HYPH cord-325324-kh2aal5n 104 26 CoV-1 CoV-1 NNP cord-325324-kh2aal5n 104 27 and and CC cord-325324-kh2aal5n 104 28 other other JJ cord-325324-kh2aal5n 104 29 closely closely RB cord-325324-kh2aal5n 104 30 SARS SARS NNP cord-325324-kh2aal5n 104 31 - - HYPH cord-325324-kh2aal5n 104 32 related relate VBN cord-325324-kh2aal5n 104 33 CoVs CoVs NNP cord-325324-kh2aal5n 104 34 ( ( -LRB- cord-325324-kh2aal5n 104 35 67 67 CD cord-325324-kh2aal5n 104 36 ) ) -RRB- cord-325324-kh2aal5n 104 37 . . . cord-325324-kh2aal5n 105 1 Recent recent JJ cord-325324-kh2aal5n 105 2 studies study NNS cord-325324-kh2aal5n 105 3 revealed reveal VBD cord-325324-kh2aal5n 105 4 that that IN cord-325324-kh2aal5n 105 5 SARS SARS NNP cord-325324-kh2aal5n 105 6 - - HYPH cord-325324-kh2aal5n 105 7 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 105 8 uses use VBZ cord-325324-kh2aal5n 105 9 ACE2 ACE2 NNP cord-325324-kh2aal5n 105 10 as as IN cord-325324-kh2aal5n 105 11 a a DT cord-325324-kh2aal5n 105 12 receptor receptor NN cord-325324-kh2aal5n 105 13 for for IN cord-325324-kh2aal5n 105 14 cellular cellular JJ cord-325324-kh2aal5n 105 15 entry entry NN cord-325324-kh2aal5n 105 16 ( ( -LRB- cord-325324-kh2aal5n 105 17 67 67 CD cord-325324-kh2aal5n 105 18 , , , cord-325324-kh2aal5n 105 19 68 68 CD cord-325324-kh2aal5n 105 20 ) ) -RRB- cord-325324-kh2aal5n 105 21 . . . cord-325324-kh2aal5n 106 1 SARS SARS NNP cord-325324-kh2aal5n 106 2 - - HYPH cord-325324-kh2aal5n 106 3 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 106 4 first first RB cord-325324-kh2aal5n 106 5 binds bind VBZ cord-325324-kh2aal5n 106 6 to to IN cord-325324-kh2aal5n 106 7 ACE2 ACE2 NNP cord-325324-kh2aal5n 106 8 via via IN cord-325324-kh2aal5n 106 9 RBD RBD NNP cord-325324-kh2aal5n 106 10 of of IN cord-325324-kh2aal5n 106 11 its -PRON- PRP$ cord-325324-kh2aal5n 106 12 spike spike NN cord-325324-kh2aal5n 106 13 protein protein NN cord-325324-kh2aal5n 106 14 and and CC cord-325324-kh2aal5n 106 15 then then RB cord-325324-kh2aal5n 106 16 fuses fuse VBZ cord-325324-kh2aal5n 106 17 viral viral JJ cord-325324-kh2aal5n 106 18 and and CC cord-325324-kh2aal5n 106 19 host host NN cord-325324-kh2aal5n 106 20 membranes membrane NNS cord-325324-kh2aal5n 106 21 ( ( -LRB- cord-325324-kh2aal5n 106 22 67 67 CD cord-325324-kh2aal5n 106 23 ) ) -RRB- cord-325324-kh2aal5n 106 24 . . . cord-325324-kh2aal5n 107 1 The the DT cord-325324-kh2aal5n 107 2 study study NN cord-325324-kh2aal5n 107 3 also also RB cord-325324-kh2aal5n 107 4 showed show VBD cord-325324-kh2aal5n 107 5 that that IN cord-325324-kh2aal5n 107 6 SARS SARS NNP cord-325324-kh2aal5n 107 7 - - HYPH cord-325324-kh2aal5n 107 8 CoV-1 CoV-1 NNP cord-325324-kh2aal5n 107 9 spike spike VBP cord-325324-kh2aal5n 107 10 polyclonal polyclonal JJ cord-325324-kh2aal5n 107 11 antibodies antibody NNS cord-325324-kh2aal5n 107 12 block block VBP cord-325324-kh2aal5n 107 13 SARS SARS NNP cord-325324-kh2aal5n 107 14 - - HYPH cord-325324-kh2aal5n 107 15 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 107 16 mediated mediate VBN cord-325324-kh2aal5n 107 17 entry entry NN cord-325324-kh2aal5n 107 18 into into IN cord-325324-kh2aal5n 107 19 host host NN cord-325324-kh2aal5n 107 20 cells cell NNS cord-325324-kh2aal5n 107 21 and and CC cord-325324-kh2aal5n 107 22 cross cross NN cord-325324-kh2aal5n 107 23 - - JJ cord-325324-kh2aal5n 107 24 neutralizing neutralize VBG cord-325324-kh2aal5n 107 25 antibodies antibody NNS cord-325324-kh2aal5n 107 26 may may MD cord-325324-kh2aal5n 107 27 provide provide VB cord-325324-kh2aal5n 107 28 protection protection NN cord-325324-kh2aal5n 107 29 against against IN cord-325324-kh2aal5n 107 30 SARS SARS NNP cord-325324-kh2aal5n 107 31 - - HYPH cord-325324-kh2aal5n 107 32 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 107 33 ( ( -LRB- cord-325324-kh2aal5n 107 34 67 67 CD cord-325324-kh2aal5n 107 35 ) ) -RRB- cord-325324-kh2aal5n 107 36 . . . cord-325324-kh2aal5n 108 1 ( ( -LRB- cord-325324-kh2aal5n 108 2 Table table NN cord-325324-kh2aal5n 108 3 2 2 CD cord-325324-kh2aal5n 108 4 ) ) -RRB- cord-325324-kh2aal5n 108 5 . . . cord-325324-kh2aal5n 109 1 For for IN cord-325324-kh2aal5n 109 2 example example NN cord-325324-kh2aal5n 109 3 , , , cord-325324-kh2aal5n 109 4 ACE2 ACE2 NNP cord-325324-kh2aal5n 109 5 residue residue NN cord-325324-kh2aal5n 109 6 S19 S19 NNP cord-325324-kh2aal5n 109 7 can can MD cord-325324-kh2aal5n 109 8 form form VB cord-325324-kh2aal5n 109 9 a a DT cord-325324-kh2aal5n 109 10 strong strong JJ cord-325324-kh2aal5n 109 11 polar polar JJ cord-325324-kh2aal5n 109 12 contact contact NN cord-325324-kh2aal5n 109 13 with with IN cord-325324-kh2aal5n 109 14 SARS SARS NNP cord-325324-kh2aal5n 109 15 - - HYPH cord-325324-kh2aal5n 109 16 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 109 17 residue residue NN cord-325324-kh2aal5n 109 18 A475 A475 NNP cord-325324-kh2aal5n 109 19 , , , cord-325324-kh2aal5n 109 20 where where WRB cord-325324-kh2aal5n 109 21 some some DT cord-325324-kh2aal5n 109 22 monoclonal monoclonal JJ cord-325324-kh2aal5n 109 23 antibodies antibody NNS cord-325324-kh2aal5n 109 24 could could MD cord-325324-kh2aal5n 109 25 not not RB cord-325324-kh2aal5n 109 26 effectively effectively RB cord-325324-kh2aal5n 109 27 neutralize neutralize VB cord-325324-kh2aal5n 109 28 the the DT cord-325324-kh2aal5n 109 29 viral viral JJ cord-325324-kh2aal5n 109 30 mutation mutation NN cord-325324-kh2aal5n 109 31 A475V A475V NNP cord-325324-kh2aal5n 109 32 in in IN cord-325324-kh2aal5n 109 33 this this DT cord-325324-kh2aal5n 109 34 site site NN cord-325324-kh2aal5n 109 35 ( ( -LRB- cord-325324-kh2aal5n 109 36 71 71 CD cord-325324-kh2aal5n 109 37 ) ) -RRB- cord-325324-kh2aal5n 109 38 . . . cord-325324-kh2aal5n 110 1 D355 D355 NNP cord-325324-kh2aal5n 110 2 in in IN cord-325324-kh2aal5n 110 3 ACE2 ACE2 NNP cord-325324-kh2aal5n 110 4 can can MD cord-325324-kh2aal5n 110 5 form form VB cord-325324-kh2aal5n 110 6 hydrogen hydrogen NN cord-325324-kh2aal5n 110 7 - - HYPH cord-325324-kh2aal5n 110 8 bonds bond NNS cord-325324-kh2aal5n 110 9 with with IN cord-325324-kh2aal5n 110 10 T500 T500 NNP cord-325324-kh2aal5n 110 11 and and CC cord-325324-kh2aal5n 110 12 G502 G502 NNP cord-325324-kh2aal5n 110 13 in in IN cord-325324-kh2aal5n 110 14 SARS SARS NNP cord-325324-kh2aal5n 110 15 - - HYPH cord-325324-kh2aal5n 110 16 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 110 17 . . . cord-325324-kh2aal5n 111 1 Molecular molecular JJ cord-325324-kh2aal5n 111 2 dynamics dynamic NNS cord-325324-kh2aal5n 111 3 study study NN cord-325324-kh2aal5n 111 4 suggested suggest VBD cord-325324-kh2aal5n 111 5 that that IN cord-325324-kh2aal5n 111 6 D355 D355 NNP cord-325324-kh2aal5n 111 7 is be VBZ cord-325324-kh2aal5n 111 8 involved involve VBN cord-325324-kh2aal5n 111 9 in in IN cord-325324-kh2aal5n 111 10 a a DT cord-325324-kh2aal5n 111 11 critical critical JJ cord-325324-kh2aal5n 111 12 hydrogen hydrogen NN cord-325324-kh2aal5n 111 13 - - HYPH cord-325324-kh2aal5n 111 14 bonding bonding NN cord-325324-kh2aal5n 111 15 network network NN cord-325324-kh2aal5n 111 16 of of IN cord-325324-kh2aal5n 111 17 RBD RBD NNP cord-325324-kh2aal5n 111 18 - - HYPH cord-325324-kh2aal5n 111 19 ACE2 ACE2 NNP cord-325324-kh2aal5n 111 20 interaction interaction NN cord-325324-kh2aal5n 111 21 ( ( -LRB- cord-325324-kh2aal5n 111 22 72 72 CD cord-325324-kh2aal5n 111 23 ) ) -RRB- cord-325324-kh2aal5n 111 24 . . . cord-325324-kh2aal5n 112 1 ACE2 ACE2 NNP cord-325324-kh2aal5n 112 2 residue residue NN cord-325324-kh2aal5n 112 3 M82 M82 NNP cord-325324-kh2aal5n 112 4 and and CC cord-325324-kh2aal5n 112 5 SARS SARS NNP cord-325324-kh2aal5n 112 6 - - HYPH cord-325324-kh2aal5n 112 7 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 112 8 residue residue NN cord-325324-kh2aal5n 112 9 F486 F486 NNS cord-325324-kh2aal5n 112 10 are be VBP cord-325324-kh2aal5n 112 11 involved involve VBN cord-325324-kh2aal5n 112 12 in in IN cord-325324-kh2aal5n 112 13 hydrophobic hydrophobic JJ cord-325324-kh2aal5n 112 14 interactions interaction NNS cord-325324-kh2aal5n 112 15 at at IN cord-325324-kh2aal5n 112 16 the the DT cord-325324-kh2aal5n 112 17 interface interface NN cord-325324-kh2aal5n 112 18 . . . cord-325324-kh2aal5n 113 1 F486 F486 NNP cord-325324-kh2aal5n 113 2 has have VBZ cord-325324-kh2aal5n 113 3 been be VBN cord-325324-kh2aal5n 113 4 identified identify VBN cord-325324-kh2aal5n 113 5 as as IN cord-325324-kh2aal5n 113 6 a a DT cord-325324-kh2aal5n 113 7 binding binding NN cord-325324-kh2aal5n 113 8 site site NN cord-325324-kh2aal5n 113 9 for for IN cord-325324-kh2aal5n 113 10 neutralizing neutralize VBG cord-325324-kh2aal5n 113 11 antibodies antibody NNS cord-325324-kh2aal5n 113 12 ( ( -LRB- cord-325324-kh2aal5n 113 13 73 73 CD cord-325324-kh2aal5n 113 14 ) ) -RRB- cord-325324-kh2aal5n 113 15 . . . cord-325324-kh2aal5n 114 1 These these DT cord-325324-kh2aal5n 114 2 results result NNS cord-325324-kh2aal5n 114 3 explain explain VBP cord-325324-kh2aal5n 114 4 the the DT cord-325324-kh2aal5n 114 5 efficient efficient JJ cord-325324-kh2aal5n 114 6 transmission transmission NN cord-325324-kh2aal5n 114 7 of of IN cord-325324-kh2aal5n 114 8 SARS SARS NNP cord-325324-kh2aal5n 114 9 - - HYPH cord-325324-kh2aal5n 114 10 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 114 11 in in IN cord-325324-kh2aal5n 114 12 humans human NNS cord-325324-kh2aal5n 114 13 . . . cord-325324-kh2aal5n 115 1 The the DT cord-325324-kh2aal5n 115 2 sequence sequence NN cord-325324-kh2aal5n 115 3 variants variant VBZ cord-325324-kh2aal5n 115 4 in in IN cord-325324-kh2aal5n 115 5 ACE2 ACE2 NNP cord-325324-kh2aal5n 115 6 have have VBP cord-325324-kh2aal5n 115 7 been be VBN cord-325324-kh2aal5n 115 8 found find VBN cord-325324-kh2aal5n 115 9 to to TO cord-325324-kh2aal5n 115 10 be be VB cord-325324-kh2aal5n 115 11 related relate VBN cord-325324-kh2aal5n 115 12 to to IN cord-325324-kh2aal5n 115 13 human human JJ cord-325324-kh2aal5n 115 14 complex complex JJ cord-325324-kh2aal5n 115 15 disorders disorder NNS cord-325324-kh2aal5n 115 16 . . . cord-325324-kh2aal5n 116 1 Several several JJ cord-325324-kh2aal5n 116 2 case case NN cord-325324-kh2aal5n 116 3 - - HYPH cord-325324-kh2aal5n 116 4 control control NN cord-325324-kh2aal5n 116 5 association association NNP cord-325324-kh2aal5n 116 6 studies study NNS cord-325324-kh2aal5n 116 7 identified identify VBD cord-325324-kh2aal5n 116 8 the the DT cord-325324-kh2aal5n 116 9 ACE2 ACE2 NNP cord-325324-kh2aal5n 116 10 genetic genetic JJ cord-325324-kh2aal5n 116 11 single single JJ cord-325324-kh2aal5n 116 12 nucleotide nucleotide JJ cord-325324-kh2aal5n 116 13 polymorphisms polymorphism NNS cord-325324-kh2aal5n 116 14 associated associate VBN cord-325324-kh2aal5n 116 15 with with IN cord-325324-kh2aal5n 116 16 hypertension hypertension NN cord-325324-kh2aal5n 116 17 ( ( -LRB- cord-325324-kh2aal5n 116 18 74 74 CD cord-325324-kh2aal5n 116 19 , , , cord-325324-kh2aal5n 116 20 75 75 CD cord-325324-kh2aal5n 116 21 ) ) -RRB- cord-325324-kh2aal5n 116 22 . . . cord-325324-kh2aal5n 117 1 The the DT cord-325324-kh2aal5n 117 2 coding coding NN cord-325324-kh2aal5n 117 3 mutations mutation NNS cord-325324-kh2aal5n 117 4 in in IN cord-325324-kh2aal5n 117 5 key key JJ cord-325324-kh2aal5n 117 6 residues residue NNS cord-325324-kh2aal5n 117 7 of of IN cord-325324-kh2aal5n 117 8 ACE2 ACE2 NNP cord-325324-kh2aal5n 117 9 may may MD cord-325324-kh2aal5n 117 10 alter alter VB cord-325324-kh2aal5n 117 11 the the DT cord-325324-kh2aal5n 117 12 binding bind VBG cord-325324-kh2aal5n 117 13 affinity affinity NN cord-325324-kh2aal5n 117 14 of of IN cord-325324-kh2aal5n 117 15 SARS SARS NNP cord-325324-kh2aal5n 117 16 - - HYPH cord-325324-kh2aal5n 117 17 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 117 18 / / SYM cord-325324-kh2aal5n 117 19 ACE2 ACE2 NNP cord-325324-kh2aal5n 117 20 complex complex NN cord-325324-kh2aal5n 117 21 and and CC cord-325324-kh2aal5n 117 22 change change VBP cord-325324-kh2aal5n 117 23 pathogenicity pathogenicity NN cord-325324-kh2aal5n 117 24 of of IN cord-325324-kh2aal5n 117 25 ACE2 ACE2 NNP cord-325324-kh2aal5n 117 26 . . . cord-325324-kh2aal5n 118 1 Highthroughput highthroughput NN cord-325324-kh2aal5n 118 2 sequencing sequencing NN cord-325324-kh2aal5n 118 3 technologies technology NNS cord-325324-kh2aal5n 118 4 have have VBP cord-325324-kh2aal5n 118 5 been be VBN cord-325324-kh2aal5n 118 6 used use VBN cord-325324-kh2aal5n 118 7 to to TO cord-325324-kh2aal5n 118 8 identify identify VB cord-325324-kh2aal5n 118 9 the the DT cord-325324-kh2aal5n 118 10 rare rare JJ cord-325324-kh2aal5n 118 11 single single JJ cord-325324-kh2aal5n 118 12 nucleotide nucleotide JJ cord-325324-kh2aal5n 118 13 variants variant NNS cord-325324-kh2aal5n 118 14 ( ( -LRB- cord-325324-kh2aal5n 118 15 SNVs snv NNS cord-325324-kh2aal5n 118 16 ) ) -RRB- cord-325324-kh2aal5n 118 17 in in IN cord-325324-kh2aal5n 118 18 different different JJ cord-325324-kh2aal5n 118 19 populations population NNS cord-325324-kh2aal5n 118 20 . . . cord-325324-kh2aal5n 119 1 We -PRON- PRP cord-325324-kh2aal5n 119 2 collected collect VBD cord-325324-kh2aal5n 119 3 227 227 CD cord-325324-kh2aal5n 119 4 missense missense NN cord-325324-kh2aal5n 119 5 variants variant NNS cord-325324-kh2aal5n 119 6 from from IN cord-325324-kh2aal5n 119 7 the the DT cord-325324-kh2aal5n 119 8 Genome Genome NNP cord-325324-kh2aal5n 119 9 Aggregation Aggregation NNP cord-325324-kh2aal5n 119 10 Database Database NNP cord-325324-kh2aal5n 119 11 ( ( -LRB- cord-325324-kh2aal5n 119 12 gnomAD gnomAD NNP cord-325324-kh2aal5n 119 13 : : : cord-325324-kh2aal5n 119 14 https://gnomad.broadinstitute.org/ https://gnomad.broadinstitute.org/ ADD cord-325324-kh2aal5n 119 15 ) ) -RRB- cord-325324-kh2aal5n 119 16 . . . cord-325324-kh2aal5n 120 1 Of of IN cord-325324-kh2aal5n 120 2 227 227 CD cord-325324-kh2aal5n 120 3 missense missense NN cord-325324-kh2aal5n 120 4 SNVs snv NNS cord-325324-kh2aal5n 120 5 , , , cord-325324-kh2aal5n 120 6 6 6 CD cord-325324-kh2aal5n 120 7 rare rare JJ cord-325324-kh2aal5n 120 8 mutations mutation NNS cord-325324-kh2aal5n 120 9 can can MD cord-325324-kh2aal5n 120 10 be be VB cord-325324-kh2aal5n 120 11 mapped map VBN cord-325324-kh2aal5n 120 12 onto onto IN cord-325324-kh2aal5n 120 13 the the DT cord-325324-kh2aal5n 120 14 contact contact NN cord-325324-kh2aal5n 120 15 residues residue NNS cord-325324-kh2aal5n 120 16 at at IN cord-325324-kh2aal5n 120 17 the the DT cord-325324-kh2aal5n 120 18 SARS SARS NNP cord-325324-kh2aal5n 120 19 - - HYPH cord-325324-kh2aal5n 120 20 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 120 21 RBD RBD NNP cord-325324-kh2aal5n 120 22 / / SYM cord-325324-kh2aal5n 120 23 ACE2 ACE2 NNP cord-325324-kh2aal5n 120 24 interface interface NN cord-325324-kh2aal5n 120 25 ( ( -LRB- cord-325324-kh2aal5n 120 26 Table table NN cord-325324-kh2aal5n 120 27 2 2 CD cord-325324-kh2aal5n 120 28 and and CC cord-325324-kh2aal5n 120 29 Figure figure NN cord-325324-kh2aal5n 120 30 2 2 CD cord-325324-kh2aal5n 120 31 ) ) -RRB- cord-325324-kh2aal5n 120 32 . . . cord-325324-kh2aal5n 121 1 S19P S19P NNP cord-325324-kh2aal5n 121 2 ( ( -LRB- cord-325324-kh2aal5n 121 3 rs73635825 rs73635825 NNP cord-325324-kh2aal5n 121 4 ) ) -RRB- cord-325324-kh2aal5n 121 5 and and CC cord-325324-kh2aal5n 121 6 T27A T27A NNS cord-325324-kh2aal5n 121 7 ( ( -LRB- cord-325324-kh2aal5n 121 8 rs781255386 rs781255386 RB cord-325324-kh2aal5n 121 9 ) ) -RRB- cord-325324-kh2aal5n 121 10 have have VBP cord-325324-kh2aal5n 121 11 positive positive JJ cord-325324-kh2aal5n 121 12 binding bind VBG cord-325324-kh2aal5n 121 13 energy energy NN cord-325324-kh2aal5n 121 14 changes change NNS cord-325324-kh2aal5n 121 15 , , , cord-325324-kh2aal5n 121 16 indicating indicate VBG cord-325324-kh2aal5n 121 17 that that IN cord-325324-kh2aal5n 121 18 these these DT cord-325324-kh2aal5n 121 19 two two CD cord-325324-kh2aal5n 121 20 SNVs snv NNS cord-325324-kh2aal5n 121 21 can can MD cord-325324-kh2aal5n 121 22 increase increase VB cord-325324-kh2aal5n 121 23 the the DT cord-325324-kh2aal5n 121 24 ACE2-RBD ACE2-RBD NNP cord-325324-kh2aal5n 121 25 binding binding NN cord-325324-kh2aal5n 121 26 affinity affinity NN cord-325324-kh2aal5n 121 27 . . . cord-325324-kh2aal5n 122 1 S19P S19P NNP cord-325324-kh2aal5n 122 2 has have VBZ cord-325324-kh2aal5n 122 3 63 63 CD cord-325324-kh2aal5n 122 4 alleles allele NNS cord-325324-kh2aal5n 122 5 ( ( -LRB- cord-325324-kh2aal5n 122 6 0.3 0.3 CD cord-325324-kh2aal5n 122 7 % % NN cord-325324-kh2aal5n 122 8 allele allele NN cord-325324-kh2aal5n 122 9 frequency frequency NN cord-325324-kh2aal5n 122 10 ) ) -RRB- cord-325324-kh2aal5n 122 11 in in IN cord-325324-kh2aal5n 122 12 the the DT cord-325324-kh2aal5n 122 13 African african JJ cord-325324-kh2aal5n 122 14 population population NN cord-325324-kh2aal5n 122 15 . . . cord-325324-kh2aal5n 123 1 S19 S19 NNP cord-325324-kh2aal5n 123 2 is be VBZ cord-325324-kh2aal5n 123 3 interacting interact VBG cord-325324-kh2aal5n 123 4 partner partner NN cord-325324-kh2aal5n 123 5 of of IN cord-325324-kh2aal5n 123 6 SARS SARS NNP cord-325324-kh2aal5n 123 7 - - HYPH cord-325324-kh2aal5n 123 8 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 123 9 residue residue NN cord-325324-kh2aal5n 123 10 A475 a475 NN cord-325324-kh2aal5n 123 11 ( ( -LRB- cord-325324-kh2aal5n 123 12 69 69 CD cord-325324-kh2aal5n 123 13 ) ) -RRB- cord-325324-kh2aal5n 123 14 . . . cord-325324-kh2aal5n 124 1 It -PRON- PRP cord-325324-kh2aal5n 124 2 's be VBZ cord-325324-kh2aal5n 124 3 observed observe VBN cord-325324-kh2aal5n 124 4 the the DT cord-325324-kh2aal5n 124 5 SARS SARS NNP cord-325324-kh2aal5n 124 6 - - HYPH cord-325324-kh2aal5n 124 7 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 124 8 mutation mutation NN cord-325324-kh2aal5n 125 1 A475V A475V NNP cord-325324-kh2aal5n 125 2 can can MD cord-325324-kh2aal5n 125 3 reduce reduce VB cord-325324-kh2aal5n 125 4 the the DT cord-325324-kh2aal5n 125 5 sensitivity sensitivity NN cord-325324-kh2aal5n 125 6 to to IN cord-325324-kh2aal5n 125 7 some some DT cord-325324-kh2aal5n 125 8 monoclonal monoclonal JJ cord-325324-kh2aal5n 125 9 antibodies antibody NNS cord-325324-kh2aal5n 125 10 ( ( -LRB- cord-325324-kh2aal5n 125 11 71 71 CD cord-325324-kh2aal5n 125 12 ) ) -RRB- cord-325324-kh2aal5n 125 13 . . . cord-325324-kh2aal5n 126 1 The the DT cord-325324-kh2aal5n 126 2 increased increase VBN cord-325324-kh2aal5n 126 3 binding bind VBG cord-325324-kh2aal5n 126 4 affinity affinity NN cord-325324-kh2aal5n 126 5 may may MD cord-325324-kh2aal5n 126 6 result result VB cord-325324-kh2aal5n 126 7 the the DT cord-325324-kh2aal5n 126 8 SARS SARS NNP cord-325324-kh2aal5n 126 9 - - HYPH cord-325324-kh2aal5n 126 10 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 126 11 mutant mutant NN cord-325324-kh2aal5n 126 12 became become VBD cord-325324-kh2aal5n 126 13 resistant resistant JJ cord-325324-kh2aal5n 126 14 to to IN cord-325324-kh2aal5n 126 15 neutralizing neutralize VBG cord-325324-kh2aal5n 126 16 antibodies antibody NNS cord-325324-kh2aal5n 126 17 . . . cord-325324-kh2aal5n 127 1 In in IN cord-325324-kh2aal5n 127 2 addition addition NN cord-325324-kh2aal5n 127 3 , , , cord-325324-kh2aal5n 127 4 S19P S19P NNP cord-325324-kh2aal5n 127 5 in in IN cord-325324-kh2aal5n 127 6 African african JJ cord-325324-kh2aal5n 127 7 population population NN cord-325324-kh2aal5n 127 8 is be VBZ cord-325324-kh2aal5n 127 9 predicted predict VBN cord-325324-kh2aal5n 127 10 as as IN cord-325324-kh2aal5n 127 11 a a DT cord-325324-kh2aal5n 127 12 possibly possibly RB cord-325324-kh2aal5n 127 13 damaging damaging JJ cord-325324-kh2aal5n 127 14 variant variant NN cord-325324-kh2aal5n 127 15 . . . cord-325324-kh2aal5n 128 1 In in IN cord-325324-kh2aal5n 128 2 contrast contrast NN cord-325324-kh2aal5n 128 3 , , , cord-325324-kh2aal5n 128 4 T27A T27A NNS cord-325324-kh2aal5n 128 5 present present JJ cord-325324-kh2aal5n 128 6 in in IN cord-325324-kh2aal5n 128 7 Latino latino JJ cord-325324-kh2aal5n 128 8 population population NN cord-325324-kh2aal5n 128 9 are be VBP cord-325324-kh2aal5n 128 10 predicted predict VBN cord-325324-kh2aal5n 128 11 to to TO cord-325324-kh2aal5n 128 12 be be VB cord-325324-kh2aal5n 128 13 a a DT cord-325324-kh2aal5n 128 14 benign benign JJ cord-325324-kh2aal5n 128 15 variant variant NN cord-325324-kh2aal5n 128 16 . . . cord-325324-kh2aal5n 129 1 The the DT cord-325324-kh2aal5n 129 2 other other JJ cord-325324-kh2aal5n 129 3 four four CD cord-325324-kh2aal5n 129 4 mutations mutation NNS cord-325324-kh2aal5n 129 5 ( ( -LRB- cord-325324-kh2aal5n 130 1 E35 E35 NNP cord-325324-kh2aal5n 130 2 K K NNP cord-325324-kh2aal5n 130 3 , , , cord-325324-kh2aal5n 130 4 E37 E37 NNP cord-325324-kh2aal5n 130 5 K K NNP cord-325324-kh2aal5n 130 6 , , , cord-325324-kh2aal5n 130 7 M82I M82I NNP cord-325324-kh2aal5n 130 8 and and CC cord-325324-kh2aal5n 130 9 D355N D355N NNP cord-325324-kh2aal5n 130 10 ) ) -RRB- cord-325324-kh2aal5n 130 11 have have VBP cord-325324-kh2aal5n 130 12 negative negative JJ cord-325324-kh2aal5n 130 13 binding bind VBG cord-325324-kh2aal5n 130 14 energy energy NN cord-325324-kh2aal5n 130 15 changes change NNS cord-325324-kh2aal5n 130 16 and and CC cord-325324-kh2aal5n 130 17 can can MD cord-325324-kh2aal5n 130 18 weaken weaken VB cord-325324-kh2aal5n 130 19 the the DT cord-325324-kh2aal5n 130 20 binding bind VBG cord-325324-kh2aal5n 130 21 affinity affinity NN cord-325324-kh2aal5n 130 22 of of IN cord-325324-kh2aal5n 130 23 SARS SARS NNP cord-325324-kh2aal5n 130 24 - - HYPH cord-325324-kh2aal5n 130 25 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 130 26 / / SYM cord-325324-kh2aal5n 130 27 ACE2 ACE2 NNP cord-325324-kh2aal5n 130 28 complex complex NN cord-325324-kh2aal5n 130 29 . . . cord-325324-kh2aal5n 131 1 One one CD cord-325324-kh2aal5n 131 2 possible possible JJ cord-325324-kh2aal5n 131 3 explanation explanation NN cord-325324-kh2aal5n 131 4 is be VBZ cord-325324-kh2aal5n 131 5 that that IN cord-325324-kh2aal5n 131 6 these these DT cord-325324-kh2aal5n 131 7 mutations mutation NNS cord-325324-kh2aal5n 131 8 can can MD cord-325324-kh2aal5n 131 9 disrupt disrupt VB cord-325324-kh2aal5n 131 10 the the DT cord-325324-kh2aal5n 131 11 interaction interaction NN cord-325324-kh2aal5n 131 12 network network NN cord-325324-kh2aal5n 131 13 of of IN cord-325324-kh2aal5n 131 14 protein protein NN cord-325324-kh2aal5n 131 15 complex complex NN cord-325324-kh2aal5n 131 16 . . . cord-325324-kh2aal5n 132 1 For for IN cord-325324-kh2aal5n 132 2 example example NN cord-325324-kh2aal5n 132 3 , , , cord-325324-kh2aal5n 132 4 D355 d355 CD cord-325324-kh2aal5n 132 5 forms form NNS cord-325324-kh2aal5n 132 6 a a DT cord-325324-kh2aal5n 132 7 hydrogen hydrogen NN cord-325324-kh2aal5n 132 8 bond bond NN cord-325324-kh2aal5n 132 9 with with IN cord-325324-kh2aal5n 132 10 SARS SARS NNP cord-325324-kh2aal5n 132 11 - - HYPH cord-325324-kh2aal5n 132 12 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 132 13 residues residue NNS cord-325324-kh2aal5n 132 14 T500 T500 NNP cord-325324-kh2aal5n 132 15 ( ( -LRB- cord-325324-kh2aal5n 132 16 72 72 CD cord-325324-kh2aal5n 132 17 ) ) -RRB- cord-325324-kh2aal5n 132 18 , , , cord-325324-kh2aal5n 132 19 D355N D355N NNP cord-325324-kh2aal5n 132 20 ( ( -LRB- cord-325324-kh2aal5n 132 21 rs961360700 rs961360700 NNP cord-325324-kh2aal5n 132 22 ) ) -RRB- cord-325324-kh2aal5n 132 23 in in IN cord-325324-kh2aal5n 132 24 European european JJ cord-325324-kh2aal5n 132 25 population population NN cord-325324-kh2aal5n 132 26 ( ( -LRB- cord-325324-kh2aal5n 132 27 non non JJ cord-325324-kh2aal5n 132 28 - - JJ cord-325324-kh2aal5n 132 29 Finnish finnish JJ cord-325324-kh2aal5n 132 30 ) ) -RRB- cord-325324-kh2aal5n 132 31 can can MD cord-325324-kh2aal5n 132 32 break break VB cord-325324-kh2aal5n 132 33 this this DT cord-325324-kh2aal5n 132 34 hydrogen hydrogen NN cord-325324-kh2aal5n 132 35 - - HYPH cord-325324-kh2aal5n 132 36 bonding bonding NN cord-325324-kh2aal5n 132 37 network network NN cord-325324-kh2aal5n 132 38 and and CC cord-325324-kh2aal5n 132 39 reduce reduce VB cord-325324-kh2aal5n 132 40 the the DT cord-325324-kh2aal5n 132 41 protein protein NN cord-325324-kh2aal5n 132 42 - - HYPH cord-325324-kh2aal5n 132 43 protein protein NN cord-325324-kh2aal5n 132 44 interaction interaction NN cord-325324-kh2aal5n 132 45 between between IN cord-325324-kh2aal5n 132 46 SARS SARS NNP cord-325324-kh2aal5n 132 47 - - HYPH cord-325324-kh2aal5n 132 48 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 132 49 spike spike NN cord-325324-kh2aal5n 132 50 RBD RBD NNP cord-325324-kh2aal5n 132 51 and and CC cord-325324-kh2aal5n 132 52 ACE2 ACE2 NNP cord-325324-kh2aal5n 132 53 . . . cord-325324-kh2aal5n 133 1 These these DT cord-325324-kh2aal5n 133 2 findings finding NNS cord-325324-kh2aal5n 133 3 indicate indicate VBP cord-325324-kh2aal5n 133 4 that that IN cord-325324-kh2aal5n 133 5 the the DT cord-325324-kh2aal5n 133 6 sequence sequence NN cord-325324-kh2aal5n 133 7 variants variant NNS cord-325324-kh2aal5n 133 8 in in IN cord-325324-kh2aal5n 133 9 different different JJ cord-325324-kh2aal5n 133 10 populations population NNS cord-325324-kh2aal5n 133 11 can can MD cord-325324-kh2aal5n 133 12 have have VB cord-325324-kh2aal5n 133 13 different different JJ cord-325324-kh2aal5n 133 14 effects effect NNS cord-325324-kh2aal5n 133 15 on on IN cord-325324-kh2aal5n 133 16 protein protein NN cord-325324-kh2aal5n 133 17 function function NN cord-325324-kh2aal5n 133 18 of of IN cord-325324-kh2aal5n 133 19 ACE2 ACE2 NNP cord-325324-kh2aal5n 133 20 and and CC cord-325324-kh2aal5n 133 21 the the DT cord-325324-kh2aal5n 133 22 protein protein NN cord-325324-kh2aal5n 133 23 - - HYPH cord-325324-kh2aal5n 133 24 protein protein NN cord-325324-kh2aal5n 133 25 interaction interaction NN cord-325324-kh2aal5n 133 26 between between IN cord-325324-kh2aal5n 133 27 ACE2 ACE2 NNP cord-325324-kh2aal5n 133 28 and and CC cord-325324-kh2aal5n 133 29 SARS SARS NNP cord-325324-kh2aal5n 133 30 - - HYPH cord-325324-kh2aal5n 133 31 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 133 32 spike spike NN cord-325324-kh2aal5n 133 33 protein protein NN cord-325324-kh2aal5n 133 34 , , , cord-325324-kh2aal5n 133 35 which which WDT cord-325324-kh2aal5n 133 36 may may MD cord-325324-kh2aal5n 133 37 result result VB cord-325324-kh2aal5n 133 38 in in IN cord-325324-kh2aal5n 133 39 the the DT cord-325324-kh2aal5n 133 40 different different JJ cord-325324-kh2aal5n 133 41 health health NN cord-325324-kh2aal5n 133 42 disparities disparity NNS cord-325324-kh2aal5n 133 43 of of IN cord-325324-kh2aal5n 133 44 COVID-19 COVID-19 NNP cord-325324-kh2aal5n 133 45 . . . cord-325324-kh2aal5n 134 1 Different different JJ cord-325324-kh2aal5n 134 2 disparities disparity NNS cord-325324-kh2aal5n 134 3 have have VBP cord-325324-kh2aal5n 134 4 been be VBN cord-325324-kh2aal5n 134 5 reported report VBN cord-325324-kh2aal5n 134 6 in in IN cord-325324-kh2aal5n 134 7 populations population NNS cord-325324-kh2aal5n 134 8 with with IN cord-325324-kh2aal5n 134 9 COVID-19 covid-19 JJ cord-325324-kh2aal5n 134 10 whose whose WP$ cord-325324-kh2aal5n 134 11 deaths death NNS cord-325324-kh2aal5n 134 12 are be VBP cord-325324-kh2aal5n 134 13 related relate VBN cord-325324-kh2aal5n 134 14 to to IN cord-325324-kh2aal5n 134 15 older old JJR cord-325324-kh2aal5n 134 16 age age NN cord-325324-kh2aal5n 134 17 , , , cord-325324-kh2aal5n 134 18 male male JJ cord-325324-kh2aal5n 134 19 sex sex NN cord-325324-kh2aal5n 134 20 , , , cord-325324-kh2aal5n 134 21 and and CC cord-325324-kh2aal5n 134 22 concomitant concomitant JJ cord-325324-kh2aal5n 134 23 diseases disease NNS cord-325324-kh2aal5n 134 24 ( ( -LRB- cord-325324-kh2aal5n 134 25 34 34 CD cord-325324-kh2aal5n 134 26 ) ) -RRB- cord-325324-kh2aal5n 134 27 . . . cord-325324-kh2aal5n 135 1 First first RB cord-325324-kh2aal5n 135 2 , , , cord-325324-kh2aal5n 135 3 it -PRON- PRP cord-325324-kh2aal5n 135 4 was be VBD cord-325324-kh2aal5n 135 5 noted note VBN cord-325324-kh2aal5n 135 6 that that IN cord-325324-kh2aal5n 135 7 the the DT cord-325324-kh2aal5n 135 8 deaths death NNS cord-325324-kh2aal5n 135 9 caused cause VBN cord-325324-kh2aal5n 135 10 by by IN cord-325324-kh2aal5n 135 11 COVID-19 COVID-19 NNP cord-325324-kh2aal5n 135 12 clearly clearly RB cord-325324-kh2aal5n 135 13 associate associate JJ cord-325324-kh2aal5n 135 14 with with IN cord-325324-kh2aal5n 135 15 age age NN cord-325324-kh2aal5n 135 16 of of IN cord-325324-kh2aal5n 135 17 the the DT cord-325324-kh2aal5n 135 18 patients patient NNS cord-325324-kh2aal5n 135 19 . . . cord-325324-kh2aal5n 136 1 This this DT cord-325324-kh2aal5n 136 2 was be VBD cord-325324-kh2aal5n 136 3 first first RB cord-325324-kh2aal5n 136 4 reported report VBN cord-325324-kh2aal5n 136 5 for for IN cord-325324-kh2aal5n 136 6 the the DT cord-325324-kh2aal5n 136 7 COVID-19 covid-19 JJ cord-325324-kh2aal5n 136 8 populations population NNS cord-325324-kh2aal5n 136 9 in in IN cord-325324-kh2aal5n 136 10 Wuhan Wuhan NNP cord-325324-kh2aal5n 136 11 , , , cord-325324-kh2aal5n 136 12 China China NNP cord-325324-kh2aal5n 136 13 ( ( -LRB- cord-325324-kh2aal5n 136 14 76 76 CD cord-325324-kh2aal5n 136 15 ) ) -RRB- cord-325324-kh2aal5n 136 16 where where WRB cord-325324-kh2aal5n 136 17 the the DT cord-325324-kh2aal5n 136 18 median median JJ cord-325324-kh2aal5n 136 19 age age NN cord-325324-kh2aal5n 136 20 of of IN cord-325324-kh2aal5n 136 21 patients patient NNS cord-325324-kh2aal5n 136 22 who who WP cord-325324-kh2aal5n 136 23 died die VBD cord-325324-kh2aal5n 136 24 was be VBD cord-325324-kh2aal5n 136 25 75 75 CD cord-325324-kh2aal5n 136 26 ( ( -LRB- cord-325324-kh2aal5n 136 27 range range NN cord-325324-kh2aal5n 136 28 48 48 CD cord-325324-kh2aal5n 136 29 to to TO cord-325324-kh2aal5n 136 30 89 89 CD cord-325324-kh2aal5n 136 31 ) ) -RRB- cord-325324-kh2aal5n 136 32 . . . cord-325324-kh2aal5n 137 1 Another another DT cord-325324-kh2aal5n 137 2 study study NN cord-325324-kh2aal5n 137 3 estimated estimate VBD cord-325324-kh2aal5n 137 4 the the DT cord-325324-kh2aal5n 137 5 death death NN cord-325324-kh2aal5n 137 6 rate rate NN cord-325324-kh2aal5n 137 7 in in IN cord-325324-kh2aal5n 137 8 China China NNP cord-325324-kh2aal5n 137 9 was be VBD cord-325324-kh2aal5n 137 10 0.66 0.66 CD cord-325324-kh2aal5n 137 11 % % NN cord-325324-kh2aal5n 137 12 and and CC cord-325324-kh2aal5n 137 13 was be VBD cord-325324-kh2aal5n 137 14 increasing increase VBG cord-325324-kh2aal5n 137 15 by by IN cord-325324-kh2aal5n 137 16 age age NN cord-325324-kh2aal5n 137 17 to to IN cord-325324-kh2aal5n 137 18 6.4 6.4 CD cord-325324-kh2aal5n 137 19 % % NN cord-325324-kh2aal5n 137 20 for for IN cord-325324-kh2aal5n 137 21 age age NN cord-325324-kh2aal5n 137 22 60 60 CD cord-325324-kh2aal5n 137 23 and and CC cord-325324-kh2aal5n 137 24 older old JJR cord-325324-kh2aal5n 137 25 , , , cord-325324-kh2aal5n 137 26 and and CC cord-325324-kh2aal5n 137 27 to to IN cord-325324-kh2aal5n 137 28 13.8 13.8 CD cord-325324-kh2aal5n 137 29 % % NN cord-325324-kh2aal5n 137 30 for for IN cord-325324-kh2aal5n 137 31 age age NN cord-325324-kh2aal5n 137 32 of of IN cord-325324-kh2aal5n 137 33 80 80 CD cord-325324-kh2aal5n 137 34 or or CC cord-325324-kh2aal5n 137 35 older old JJR cord-325324-kh2aal5n 137 36 ( ( -LRB- cord-325324-kh2aal5n 137 37 77 77 CD cord-325324-kh2aal5n 137 38 , , , cord-325324-kh2aal5n 137 39 78 78 CD cord-325324-kh2aal5n 137 40 ) ) -RRB- cord-325324-kh2aal5n 137 41 . . . cord-325324-kh2aal5n 138 1 A a DT cord-325324-kh2aal5n 138 2 similar similar JJ cord-325324-kh2aal5n 138 3 situation situation NN cord-325324-kh2aal5n 138 4 was be VBD cord-325324-kh2aal5n 138 5 confirmed confirm VBN cord-325324-kh2aal5n 138 6 in in IN cord-325324-kh2aal5n 138 7 UK UK NNP cord-325324-kh2aal5n 138 8 with with IN cord-325324-kh2aal5n 138 9 80 80 CD cord-325324-kh2aal5n 138 10 % % NN cord-325324-kh2aal5n 138 11 of of IN cord-325324-kh2aal5n 138 12 COVID-19-related covid-19-related JJ cord-325324-kh2aal5n 138 13 deaths death NNS cord-325324-kh2aal5n 138 14 in in IN cord-325324-kh2aal5n 138 15 those those DT cord-325324-kh2aal5n 138 16 aged age VBN cord-325324-kh2aal5n 138 17 65 65 CD cord-325324-kh2aal5n 138 18 years year NNS cord-325324-kh2aal5n 138 19 and and CC cord-325324-kh2aal5n 138 20 over over RB cord-325324-kh2aal5n 138 21 and and CC cord-325324-kh2aal5n 138 22 in in IN cord-325324-kh2aal5n 138 23 the the DT cord-325324-kh2aal5n 138 24 USA USA NNP cord-325324-kh2aal5n 138 25 with with IN cord-325324-kh2aal5n 138 26 those those DT cord-325324-kh2aal5n 138 27 in in IN cord-325324-kh2aal5n 138 28 the the DT cord-325324-kh2aal5n 138 29 65 65 CD cord-325324-kh2aal5n 138 30 - - SYM cord-325324-kh2aal5n 138 31 84 84 CD cord-325324-kh2aal5n 138 32 years year NNS cord-325324-kh2aal5n 138 33 age age NN cord-325324-kh2aal5n 138 34 group group NN cord-325324-kh2aal5n 138 35 accounting account VBG cord-325324-kh2aal5n 138 36 for for IN cord-325324-kh2aal5n 138 37 25 25 CD cord-325324-kh2aal5n 138 38 % % NN cord-325324-kh2aal5n 138 39 of of IN cord-325324-kh2aal5n 138 40 cases case NNS cord-325324-kh2aal5n 138 41 , , , cord-325324-kh2aal5n 138 42 46 46 CD cord-325324-kh2aal5n 138 43 % % NN cord-325324-kh2aal5n 138 44 of of IN cord-325324-kh2aal5n 138 45 intensive intensive JJ cord-325324-kh2aal5n 138 46 care care NN cord-325324-kh2aal5n 138 47 unit unit NN cord-325324-kh2aal5n 138 48 admissions admission NNS cord-325324-kh2aal5n 138 49 and and CC cord-325324-kh2aal5n 138 50 46 46 CD cord-325324-kh2aal5n 138 51 % % NN cord-325324-kh2aal5n 138 52 of of IN cord-325324-kh2aal5n 138 53 deaths death NNS cord-325324-kh2aal5n 138 54 ( ( -LRB- cord-325324-kh2aal5n 138 55 79 79 CD cord-325324-kh2aal5n 138 56 , , , cord-325324-kh2aal5n 138 57 80 80 CD cord-325324-kh2aal5n 138 58 ) ) -RRB- cord-325324-kh2aal5n 138 59 . . . cord-325324-kh2aal5n 139 1 The the DT cord-325324-kh2aal5n 139 2 link link NN cord-325324-kh2aal5n 139 3 between between IN cord-325324-kh2aal5n 139 4 death death NN cord-325324-kh2aal5n 139 5 rate rate NN cord-325324-kh2aal5n 139 6 and and CC cord-325324-kh2aal5n 139 7 age age NN cord-325324-kh2aal5n 139 8 has have VBZ cord-325324-kh2aal5n 139 9 been be VBN cord-325324-kh2aal5n 139 10 observed observe VBN cord-325324-kh2aal5n 139 11 in in IN cord-325324-kh2aal5n 139 12 many many JJ cord-325324-kh2aal5n 139 13 countries country NNS cord-325324-kh2aal5n 139 14 ( ( -LRB- cord-325324-kh2aal5n 139 15 81 81 CD cord-325324-kh2aal5n 139 16 ) ) -RRB- cord-325324-kh2aal5n 139 17 . . . cord-325324-kh2aal5n 140 1 Many many JJ cord-325324-kh2aal5n 140 2 factors factor NNS cord-325324-kh2aal5n 140 3 could could MD cord-325324-kh2aal5n 140 4 connect connect VB cord-325324-kh2aal5n 140 5 age age NN cord-325324-kh2aal5n 140 6 to to IN cord-325324-kh2aal5n 140 7 COVID-19-caused covid-19-caused JJ cord-325324-kh2aal5n 140 8 fatalities fatality NNS cord-325324-kh2aal5n 140 9 . . . cord-325324-kh2aal5n 141 1 One one CD cord-325324-kh2aal5n 141 2 of of IN cord-325324-kh2aal5n 141 3 the the DT cord-325324-kh2aal5n 141 4 important important JJ cord-325324-kh2aal5n 141 5 facts fact NNS cord-325324-kh2aal5n 141 6 is be VBZ cord-325324-kh2aal5n 141 7 that that IN cord-325324-kh2aal5n 141 8 the the DT cord-325324-kh2aal5n 141 9 aforementioned aforementioned JJ cord-325324-kh2aal5n 141 10 comorbidities comorbiditie NNS cord-325324-kh2aal5n 141 11 of of IN cord-325324-kh2aal5n 141 12 hypertension hypertension NN cord-325324-kh2aal5n 141 13 , , , cord-325324-kh2aal5n 141 14 DM DM NNP cord-325324-kh2aal5n 141 15 and and CC cord-325324-kh2aal5n 141 16 CVDs cvd NNS cord-325324-kh2aal5n 141 17 are be VBP cord-325324-kh2aal5n 141 18 less less RBR cord-325324-kh2aal5n 141 19 common common JJ cord-325324-kh2aal5n 141 20 in in IN cord-325324-kh2aal5n 141 21 younger young JJR cord-325324-kh2aal5n 141 22 people people NNS cord-325324-kh2aal5n 141 23 than than IN cord-325324-kh2aal5n 141 24 that that DT cord-325324-kh2aal5n 141 25 in in IN cord-325324-kh2aal5n 141 26 older old JJR cord-325324-kh2aal5n 141 27 people people NNS cord-325324-kh2aal5n 141 28 . . . cord-325324-kh2aal5n 142 1 The the DT cord-325324-kh2aal5n 142 2 underlying underlie VBG cord-325324-kh2aal5n 142 3 diseases disease NNS cord-325324-kh2aal5n 142 4 links link NNS cord-325324-kh2aal5n 142 5 to to IN cord-325324-kh2aal5n 142 6 both both CC cord-325324-kh2aal5n 142 7 the the DT cord-325324-kh2aal5n 142 8 case case NN cord-325324-kh2aal5n 142 9 fatality fatality NN cord-325324-kh2aal5n 142 10 of of IN cord-325324-kh2aal5n 142 11 COVID-19 COVID-19 NNP cord-325324-kh2aal5n 142 12 and and CC cord-325324-kh2aal5n 142 13 the the DT cord-325324-kh2aal5n 142 14 economically economically RB cord-325324-kh2aal5n 142 15 disadvantaged disadvantaged JJ cord-325324-kh2aal5n 142 16 groups group NNS cord-325324-kh2aal5n 142 17 and/or and/or CC cord-325324-kh2aal5n 142 18 socially socially RB cord-325324-kh2aal5n 142 19 isolated isolate VBN cord-325324-kh2aal5n 142 20 communities community NNS cord-325324-kh2aal5n 142 21 . . . cord-325324-kh2aal5n 143 1 For for IN cord-325324-kh2aal5n 143 2 example example NN cord-325324-kh2aal5n 143 3 , , , cord-325324-kh2aal5n 143 4 as as IN cord-325324-kh2aal5n 143 5 Dr. Dr. NNP cord-325324-kh2aal5n 143 6 Yancy Yancy NNP cord-325324-kh2aal5n 143 7 summarized summarize VBD cord-325324-kh2aal5n 143 8 ( ( -LRB- cord-325324-kh2aal5n 143 9 34 34 CD cord-325324-kh2aal5n 143 10 ) ) -RRB- cord-325324-kh2aal5n 143 11 , , , cord-325324-kh2aal5n 143 12 1 1 CD cord-325324-kh2aal5n 143 13 ) ) -RRB- cord-325324-kh2aal5n 143 14 more more JJR cord-325324-kh2aal5n 143 15 than than IN cord-325324-kh2aal5n 143 16 50 50 CD cord-325324-kh2aal5n 143 17 % % NN cord-325324-kh2aal5n 143 18 of of IN cord-325324-kh2aal5n 143 19 COVID-19 covid-19 JJ cord-325324-kh2aal5n 143 20 cases case NNS cord-325324-kh2aal5n 143 21 and and CC cord-325324-kh2aal5n 143 22 nearly nearly RB cord-325324-kh2aal5n 143 23 70 70 CD cord-325324-kh2aal5n 143 24 % % NN cord-325324-kh2aal5n 143 25 of of IN cord-325324-kh2aal5n 143 26 COVID covid NN cord-325324-kh2aal5n 143 27 - - HYPH cord-325324-kh2aal5n 143 28 population population NN cord-325324-kh2aal5n 143 29 in in IN cord-325324-kh2aal5n 143 30 Chicago Chicago NNP cord-325324-kh2aal5n 143 31 ; ; : cord-325324-kh2aal5n 143 32 2 2 CD cord-325324-kh2aal5n 143 33 ) ) -RRB- cord-325324-kh2aal5n 144 1 70.5 70.5 CD cord-325324-kh2aal5n 144 2 % % NN cord-325324-kh2aal5n 144 3 of of IN cord-325324-kh2aal5n 144 4 deaths death NNS cord-325324-kh2aal5n 144 5 have have VBP cord-325324-kh2aal5n 144 6 occurred occur VBN cord-325324-kh2aal5n 144 7 among among IN cord-325324-kh2aal5n 144 8 African african JJ cord-325324-kh2aal5n 144 9 American american JJ cord-325324-kh2aal5n 144 10 persons person NNS cord-325324-kh2aal5n 144 11 , , , cord-325324-kh2aal5n 144 12 who who WP cord-325324-kh2aal5n 144 13 represent represent VBP cord-325324-kh2aal5n 144 14 32.2 32.2 CD cord-325324-kh2aal5n 144 15 % % NN cord-325324-kh2aal5n 144 16 of of IN cord-325324-kh2aal5n 144 17 the the DT cord-325324-kh2aal5n 144 18 state state NN cord-325324-kh2aal5n 144 19 's 's POS cord-325324-kh2aal5n 144 20 population population NN cord-325324-kh2aal5n 144 21 in in IN cord-325324-kh2aal5n 144 22 Louisiana Louisiana NNP cord-325324-kh2aal5n 144 23 ; ; : cord-325324-kh2aal5n 144 24 3 3 CD cord-325324-kh2aal5n 144 25 ) ) -RRB- cord-325324-kh2aal5n 144 26 33 33 CD cord-325324-kh2aal5n 144 27 % % NN cord-325324-kh2aal5n 144 28 of of IN cord-325324-kh2aal5n 144 29 COVID-19 covid-19 JJ cord-325324-kh2aal5n 144 30 cases case NNS cord-325324-kh2aal5n 144 31 and and CC cord-325324-kh2aal5n 144 32 40 40 CD cord-325324-kh2aal5n 144 33 % % NN cord-325324-kh2aal5n 144 34 of of IN cord-325324-kh2aal5n 144 35 deaths death NNS cord-325324-kh2aal5n 144 36 have have VBP cord-325324-kh2aal5n 144 37 occurred occur VBN cord-325324-kh2aal5n 144 38 among among IN cord-325324-kh2aal5n 144 39 African african JJ cord-325324-kh2aal5n 144 40 American american JJ cord-325324-kh2aal5n 144 41 individuals individual NNS cord-325324-kh2aal5n 144 42 , , , cord-325324-kh2aal5n 144 43 who who WP cord-325324-kh2aal5n 144 44 represent represent VBP cord-325324-kh2aal5n 144 45 14 14 CD cord-325324-kh2aal5n 144 46 % % NN cord-325324-kh2aal5n 144 47 of of IN cord-325324-kh2aal5n 144 48 the the DT cord-325324-kh2aal5n 144 49 population population NN cord-325324-kh2aal5n 144 50 in in IN cord-325324-kh2aal5n 144 51 Michigan Michigan NNP cord-325324-kh2aal5n 144 52 ; ; : cord-325324-kh2aal5n 144 53 and and CC cord-325324-kh2aal5n 144 54 4 4 LS cord-325324-kh2aal5n 144 55 ) ) -RRB- cord-325324-kh2aal5n 145 1 New New NNP cord-325324-kh2aal5n 145 2 York York NNP cord-325324-kh2aal5n 145 3 City City NNP cord-325324-kh2aal5n 145 4 is be VBZ cord-325324-kh2aal5n 145 5 the the DT cord-325324-kh2aal5n 145 6 epicenter epicenter NN cord-325324-kh2aal5n 145 7 of of IN cord-325324-kh2aal5n 145 8 COVID-19 COVID-19 NNP cord-325324-kh2aal5n 145 9 in in IN cord-325324-kh2aal5n 145 10 the the DT cord-325324-kh2aal5n 145 11 USA USA NNP cord-325324-kh2aal5n 145 12 , , , cord-325324-kh2aal5n 145 13 African African NNPS cord-325324-kh2aal5n 145 14 Americans Americans NNPS cord-325324-kh2aal5n 145 15 and and CC cord-325324-kh2aal5n 145 16 Hispanics Hispanics NNPS cord-325324-kh2aal5n 145 17 have have VBP cord-325324-kh2aal5n 145 18 accounted account VBN cord-325324-kh2aal5n 145 19 for for IN cord-325324-kh2aal5n 145 20 28 28 CD cord-325324-kh2aal5n 145 21 % % NN cord-325324-kh2aal5n 145 22 and and CC cord-325324-kh2aal5n 145 23 34 34 CD cord-325324-kh2aal5n 145 24 % % NN cord-325324-kh2aal5n 145 25 of of IN cord-325324-kh2aal5n 145 26 deaths death NNS cord-325324-kh2aal5n 145 27 , , , cord-325324-kh2aal5n 145 28 respectively respectively RB cord-325324-kh2aal5n 145 29 ( ( -LRB- cord-325324-kh2aal5n 145 30 population population NN cord-325324-kh2aal5n 145 31 representation representation NN cord-325324-kh2aal5n 145 32 : : : cord-325324-kh2aal5n 145 33 22 22 CD cord-325324-kh2aal5n 145 34 % % NN cord-325324-kh2aal5n 145 35 and and CC cord-325324-kh2aal5n 145 36 29 29 CD cord-325324-kh2aal5n 145 37 % % NN cord-325324-kh2aal5n 145 38 , , , cord-325324-kh2aal5n 145 39 respectively respectively RB cord-325324-kh2aal5n 145 40 ) ) -RRB- cord-325324-kh2aal5n 145 41 . . . cord-325324-kh2aal5n 146 1 Dr. Dr. NNP cord-325324-kh2aal5n 146 2 Yancy Yancy NNP cord-325324-kh2aal5n 146 3 also also RB cord-325324-kh2aal5n 146 4 noted note VBD cord-325324-kh2aal5n 146 5 that that IN cord-325324-kh2aal5n 146 6 it -PRON- PRP cord-325324-kh2aal5n 146 7 is be VBZ cord-325324-kh2aal5n 146 8 likely likely JJ cord-325324-kh2aal5n 146 9 that that IN cord-325324-kh2aal5n 146 10 some some DT cord-325324-kh2aal5n 146 11 , , , cord-325324-kh2aal5n 146 12 if if IN cord-325324-kh2aal5n 146 13 not not RB cord-325324-kh2aal5n 146 14 most most JJS cord-325324-kh2aal5n 146 15 , , , cord-325324-kh2aal5n 146 16 of of IN cord-325324-kh2aal5n 146 17 these these DT cord-325324-kh2aal5n 146 18 differences difference NNS cord-325324-kh2aal5n 146 19 in in IN cord-325324-kh2aal5n 146 20 disease disease NN cord-325324-kh2aal5n 146 21 rates rate NNS cord-325324-kh2aal5n 146 22 and and CC cord-325324-kh2aal5n 146 23 outcomes outcome NNS cord-325324-kh2aal5n 146 24 will will MD cord-325324-kh2aal5n 146 25 be be VB cord-325324-kh2aal5n 146 26 explained explain VBN cord-325324-kh2aal5n 146 27 by by IN cord-325324-kh2aal5n 146 28 concomitant concomitant JJ cord-325324-kh2aal5n 146 29 comorbidities comorbiditie NNS cord-325324-kh2aal5n 146 30 . . . cord-325324-kh2aal5n 147 1 However however RB cord-325324-kh2aal5n 147 2 , , , cord-325324-kh2aal5n 147 3 it -PRON- PRP cord-325324-kh2aal5n 147 4 is be VBZ cord-325324-kh2aal5n 147 5 possible possible JJ cord-325324-kh2aal5n 147 6 that that IN cord-325324-kh2aal5n 147 7 the the DT cord-325324-kh2aal5n 147 8 majority majority NN cord-325324-kh2aal5n 147 9 of of IN cord-325324-kh2aal5n 147 10 the the DT cord-325324-kh2aal5n 147 11 disparity disparity NN cord-325324-kh2aal5n 147 12 has have VBZ cord-325324-kh2aal5n 147 13 to to TO cord-325324-kh2aal5n 147 14 do do VB cord-325324-kh2aal5n 147 15 with with IN cord-325324-kh2aal5n 147 16 access access NN cord-325324-kh2aal5n 147 17 to to IN cord-325324-kh2aal5n 147 18 healthcare healthcare NN cord-325324-kh2aal5n 147 19 , , , cord-325324-kh2aal5n 147 20 education education NN cord-325324-kh2aal5n 147 21 about about IN cord-325324-kh2aal5n 147 22 the the DT cord-325324-kh2aal5n 147 23 virus virus NN cord-325324-kh2aal5n 147 24 and and CC cord-325324-kh2aal5n 147 25 its -PRON- PRP$ cord-325324-kh2aal5n 147 26 symptoms symptom NNS cord-325324-kh2aal5n 147 27 , , , cord-325324-kh2aal5n 147 28 or or CC cord-325324-kh2aal5n 147 29 other other JJ cord-325324-kh2aal5n 147 30 well well RB cord-325324-kh2aal5n 147 31 - - HYPH cord-325324-kh2aal5n 147 32 documented document VBN cord-325324-kh2aal5n 147 33 socioeconomic socioeconomic JJ cord-325324-kh2aal5n 147 34 disparities disparity NNS cord-325324-kh2aal5n 147 35 in in IN cord-325324-kh2aal5n 147 36 US US NNP cord-325324-kh2aal5n 147 37 healthcare healthcare NN cord-325324-kh2aal5n 147 38 . . . cord-325324-kh2aal5n 148 1 The the DT cord-325324-kh2aal5n 148 2 claims claim NNS cord-325324-kh2aal5n 148 3 that that WDT cord-325324-kh2aal5n 148 4 COVID-19 covid-19 VBP cord-325324-kh2aal5n 148 5 disproportionately disproportionately RB cord-325324-kh2aal5n 148 6 affects affect VBZ cord-325324-kh2aal5n 148 7 the the DT cord-325324-kh2aal5n 148 8 individuals individual NNS cord-325324-kh2aal5n 148 9 of of IN cord-325324-kh2aal5n 148 10 minority minority NN cord-325324-kh2aal5n 148 11 groups group NNS cord-325324-kh2aal5n 148 12 and and CC cord-325324-kh2aal5n 148 13 aged aged JJ cord-325324-kh2aal5n 148 14 people people NNS cord-325324-kh2aal5n 148 15 are be VBP cord-325324-kh2aal5n 148 16 not not RB cord-325324-kh2aal5n 148 17 only only RB cord-325324-kh2aal5n 148 18 supported support VBN cord-325324-kh2aal5n 148 19 by by IN cord-325324-kh2aal5n 148 20 reported report VBN cord-325324-kh2aal5n 148 21 data datum NNS cord-325324-kh2aal5n 148 22 but but CC cord-325324-kh2aal5n 148 23 also also RB cord-325324-kh2aal5n 148 24 by by IN cord-325324-kh2aal5n 148 25 our -PRON- PRP$ cord-325324-kh2aal5n 148 26 hypothesis hypothesis NN cord-325324-kh2aal5n 148 27 that that IN cord-325324-kh2aal5n 148 28 SARS SARS NNP cord-325324-kh2aal5n 148 29 - - HYPH cord-325324-kh2aal5n 148 30 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 148 31 infection infection NN cord-325324-kh2aal5n 148 32 generates generate VBZ cord-325324-kh2aal5n 148 33 spike spike NN cord-325324-kh2aal5n 148 34 protein protein NN cord-325324-kh2aal5n 148 35 that that WDT cord-325324-kh2aal5n 148 36 interacts interact VBZ cord-325324-kh2aal5n 148 37 with with IN cord-325324-kh2aal5n 148 38 ACE2 ACE2 NNP cord-325324-kh2aal5n 148 39 to to IN cord-325324-kh2aal5n 148 40 either either CC cord-325324-kh2aal5n 148 41 exhaust exhaust VB cord-325324-kh2aal5n 148 42 ACE2 ACE2 NNP cord-325324-kh2aal5n 148 43 or or CC cord-325324-kh2aal5n 148 44 inhibit inhibit VB cord-325324-kh2aal5n 148 45 ACE2 ACE2 NNP cord-325324-kh2aal5n 148 46 function function NN cord-325324-kh2aal5n 148 47 or or CC cord-325324-kh2aal5n 148 48 both both DT cord-325324-kh2aal5n 148 49 so so IN cord-325324-kh2aal5n 148 50 that that IN cord-325324-kh2aal5n 148 51 the the DT cord-325324-kh2aal5n 148 52 comorbidities comorbiditie NNS cord-325324-kh2aal5n 148 53 are be VBP cord-325324-kh2aal5n 148 54 aggravated aggravate VBN cord-325324-kh2aal5n 149 1 ( ( -LRB- cord-325324-kh2aal5n 149 2 Figure figure NN cord-325324-kh2aal5n 149 3 1 1 CD cord-325324-kh2aal5n 149 4 ) ) -RRB- cord-325324-kh2aal5n 149 5 . . . cord-325324-kh2aal5n 150 1 The the DT cord-325324-kh2aal5n 150 2 top top JJ cord-325324-kh2aal5n 150 3 comorbidities comorbiditie NNS cord-325324-kh2aal5n 150 4 in in IN cord-325324-kh2aal5n 150 5 COVID-19 covid-19 JJ cord-325324-kh2aal5n 150 6 patients patient NNS cord-325324-kh2aal5n 150 7 are be VBP cord-325324-kh2aal5n 150 8 hypertension hypertension NN cord-325324-kh2aal5n 150 9 , , , cord-325324-kh2aal5n 150 10 and and CC cord-325324-kh2aal5n 150 11 cardiovascular cardiovascular JJ cord-325324-kh2aal5n 150 12 disease disease NN cord-325324-kh2aal5n 150 13 , , , cord-325324-kh2aal5n 150 14 all all DT cord-325324-kh2aal5n 150 15 of of IN cord-325324-kh2aal5n 150 16 which which WDT cord-325324-kh2aal5n 150 17 are be VBP cord-325324-kh2aal5n 150 18 directly directly RB cord-325324-kh2aal5n 150 19 related relate VBN cord-325324-kh2aal5n 150 20 to to IN cord-325324-kh2aal5n 150 21 ACE2 ACE2 NNP cord-325324-kh2aal5n 150 22 . . . cord-325324-kh2aal5n 151 1 Therefore therefore RB cord-325324-kh2aal5n 151 2 , , , cord-325324-kh2aal5n 151 3 we -PRON- PRP cord-325324-kh2aal5n 151 4 suggest suggest VBP cord-325324-kh2aal5n 151 5 that that IN cord-325324-kh2aal5n 151 6 ACE2-SARS ace2-sars CD cord-325324-kh2aal5n 151 7 - - : cord-325324-kh2aal5n 151 8 CoV-2 cov-2 NN cord-325324-kh2aal5n 151 9 spike spike NN cord-325324-kh2aal5n 151 10 interaction interaction NN cord-325324-kh2aal5n 151 11 is be VBZ cord-325324-kh2aal5n 151 12 a a DT cord-325324-kh2aal5n 151 13 specific specific JJ cord-325324-kh2aal5n 151 14 target target NN cord-325324-kh2aal5n 151 15 not not RB cord-325324-kh2aal5n 151 16 only only RB cord-325324-kh2aal5n 151 17 for for IN cord-325324-kh2aal5n 151 18 treatment treatment NN cord-325324-kh2aal5n 151 19 of of IN cord-325324-kh2aal5n 151 20 the the DT cord-325324-kh2aal5n 151 21 severe severe JJ cord-325324-kh2aal5n 151 22 diseases disease NNS cord-325324-kh2aal5n 151 23 but but CC cord-325324-kh2aal5n 151 24 also also RB cord-325324-kh2aal5n 151 25 for for IN cord-325324-kh2aal5n 151 26 prophylactic prophylactic JJ cord-325324-kh2aal5n 151 27 control control NN cord-325324-kh2aal5n 151 28 of of IN cord-325324-kh2aal5n 151 29 the the DT cord-325324-kh2aal5n 151 30 infection infection NN cord-325324-kh2aal5n 151 31 of of IN cord-325324-kh2aal5n 151 32 SARS SARS NNP cord-325324-kh2aal5n 151 33 - - HYPH cord-325324-kh2aal5n 151 34 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 151 35 . . . cord-325324-kh2aal5n 152 1 The the DT cord-325324-kh2aal5n 152 2 strategies strategy NNS cord-325324-kh2aal5n 152 3 of of IN cord-325324-kh2aal5n 152 4 using use VBG cord-325324-kh2aal5n 152 5 the the DT cord-325324-kh2aal5n 152 6 target target NN cord-325324-kh2aal5n 152 7 might may MD cord-325324-kh2aal5n 152 8 be be VB cord-325324-kh2aal5n 152 9 better well JJR cord-325324-kh2aal5n 152 10 against against IN cord-325324-kh2aal5n 152 11 the the DT cord-325324-kh2aal5n 152 12 spike spike NN cord-325324-kh2aal5n 152 13 protein protein NN cord-325324-kh2aal5n 152 14 of of IN cord-325324-kh2aal5n 152 15 SARS SARS NNP cord-325324-kh2aal5n 152 16 - - HYPH cord-325324-kh2aal5n 152 17 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 152 18 than than IN cord-325324-kh2aal5n 152 19 ACE2 ACE2 NNP cord-325324-kh2aal5n 152 20 because because IN cord-325324-kh2aal5n 152 21 targeting target VBG cord-325324-kh2aal5n 152 22 ACE2 ACE2 NNP cord-325324-kh2aal5n 152 23 per per FW cord-325324-kh2aal5n 152 24 se se FW cord-325324-kh2aal5n 152 25 might may MD cord-325324-kh2aal5n 152 26 impose impose VB cord-325324-kh2aal5n 152 27 a a DT cord-325324-kh2aal5n 152 28 detrimental detrimental JJ cord-325324-kh2aal5n 152 29 effect effect NN cord-325324-kh2aal5n 152 30 on on IN cord-325324-kh2aal5n 152 31 the the DT cord-325324-kh2aal5n 152 32 patient patient NN cord-325324-kh2aal5n 152 33 who who WP cord-325324-kh2aal5n 152 34 has have VBZ cord-325324-kh2aal5n 152 35 the the DT cord-325324-kh2aal5n 152 36 underlying underlie VBG cord-325324-kh2aal5n 152 37 diseases disease NNS cord-325324-kh2aal5n 152 38 . . . cord-325324-kh2aal5n 153 1 Here here RB cord-325324-kh2aal5n 153 2 we -PRON- PRP cord-325324-kh2aal5n 153 3 reviewed review VBD cord-325324-kh2aal5n 153 4 recently recently RB cord-325324-kh2aal5n 153 5 published publish VBN cord-325324-kh2aal5n 153 6 information information NN cord-325324-kh2aal5n 153 7 with with IN cord-325324-kh2aal5n 153 8 regard regard NN cord-325324-kh2aal5n 153 9 to to IN cord-325324-kh2aal5n 153 10 COVID-19 COVID-19 NNP cord-325324-kh2aal5n 153 11 , , , cord-325324-kh2aal5n 153 12 especially especially RB cord-325324-kh2aal5n 153 13 the the DT cord-325324-kh2aal5n 153 14 biological biological JJ cord-325324-kh2aal5n 153 15 role role NN cord-325324-kh2aal5n 153 16 of of IN cord-325324-kh2aal5n 153 17 ACE2 ACE2 NNP cord-325324-kh2aal5n 153 18 in in IN cord-325324-kh2aal5n 153 19 the the DT cord-325324-kh2aal5n 153 20 pathogenesis pathogenesis NN cord-325324-kh2aal5n 153 21 of of IN cord-325324-kh2aal5n 153 22 COVID-19 covid-19 JJ cord-325324-kh2aal5n 153 23 and and CC cord-325324-kh2aal5n 153 24 certain certain JJ cord-325324-kh2aal5n 153 25 comorbid comorbid NN cord-325324-kh2aal5n 153 26 diseases disease NNS cord-325324-kh2aal5n 153 27 . . . cord-325324-kh2aal5n 154 1 We -PRON- PRP cord-325324-kh2aal5n 154 2 hypothesized hypothesize VBD cord-325324-kh2aal5n 154 3 that that IN cord-325324-kh2aal5n 154 4 ACE2 ACE2 NNP cord-325324-kh2aal5n 154 5 plays play VBZ cord-325324-kh2aal5n 154 6 a a DT cord-325324-kh2aal5n 154 7 key key JJ cord-325324-kh2aal5n 154 8 role role NN cord-325324-kh2aal5n 154 9 in in IN cord-325324-kh2aal5n 154 10 the the DT cord-325324-kh2aal5n 154 11 severity severity NN cord-325324-kh2aal5n 154 12 and and CC cord-325324-kh2aal5n 154 13 fatality fatality NN cord-325324-kh2aal5n 154 14 of of IN cord-325324-kh2aal5n 154 15 COVID-19 covid-19 JJ cord-325324-kh2aal5n 154 16 and and CC cord-325324-kh2aal5n 154 17 viral viral JJ cord-325324-kh2aal5n 154 18 infection infection NN cord-325324-kh2aal5n 154 19 exhausts exhaust VBZ cord-325324-kh2aal5n 154 20 ACE2 ACE2 NNP cord-325324-kh2aal5n 154 21 or or CC cord-325324-kh2aal5n 154 22 functionally functionally RB cord-325324-kh2aal5n 154 23 inhibits inhibit VBZ cord-325324-kh2aal5n 154 24 ACE2 ACE2 NNP cord-325324-kh2aal5n 154 25 to to TO cord-325324-kh2aal5n 154 26 aggravate aggravate VB cord-325324-kh2aal5n 154 27 the the DT cord-325324-kh2aal5n 154 28 comorbidities comorbiditie NNS cord-325324-kh2aal5n 154 29 of of IN cord-325324-kh2aal5n 154 30 COVID-19 covid-19 JJ cord-325324-kh2aal5n 154 31 patients patient NNS cord-325324-kh2aal5n 154 32 . . . cord-325324-kh2aal5n 155 1 Our -PRON- PRP$ cord-325324-kh2aal5n 155 2 hypothesis hypothesis NN cord-325324-kh2aal5n 155 3 emphasizes emphasize VBZ cord-325324-kh2aal5n 155 4 the the DT cord-325324-kh2aal5n 155 5 relationship relationship NN cord-325324-kh2aal5n 155 6 between between IN cord-325324-kh2aal5n 155 7 COVID-19 COVID-19 NNP cord-325324-kh2aal5n 155 8 and and CC cord-325324-kh2aal5n 155 9 the the DT cord-325324-kh2aal5n 155 10 comorbid comorbid NN cord-325324-kh2aal5n 155 11 diseases disease NNS cord-325324-kh2aal5n 155 12 which which WDT cord-325324-kh2aal5n 155 13 not not RB cord-325324-kh2aal5n 155 14 only only RB cord-325324-kh2aal5n 155 15 interpret interpret VBP cord-325324-kh2aal5n 155 16 high high JJ cord-325324-kh2aal5n 155 17 fatalities fatality NNS cord-325324-kh2aal5n 155 18 of of IN cord-325324-kh2aal5n 155 19 COVID-19 covid-19 CD cord-325324-kh2aal5n 155 20 in in IN cord-325324-kh2aal5n 155 21 aged aged JJ cord-325324-kh2aal5n 155 22 people people NNS cord-325324-kh2aal5n 155 23 but but CC cord-325324-kh2aal5n 155 24 may may MD cord-325324-kh2aal5n 155 25 also also RB cord-325324-kh2aal5n 155 26 contribute contribute VB cord-325324-kh2aal5n 155 27 to to IN cord-325324-kh2aal5n 155 28 socioeconomic socioeconomic JJ cord-325324-kh2aal5n 155 29 disparities disparity NNS cord-325324-kh2aal5n 155 30 of of IN cord-325324-kh2aal5n 155 31 COVID-19 COVID-19 NNP cord-325324-kh2aal5n 155 32 . . . cord-325324-kh2aal5n 156 1 The the DT cord-325324-kh2aal5n 156 2 medical medical JJ cord-325324-kh2aal5n 156 3 intervention intervention NN cord-325324-kh2aal5n 156 4 strategies strategy NNS cord-325324-kh2aal5n 156 5 of of IN cord-325324-kh2aal5n 156 6 using use VBG cord-325324-kh2aal5n 156 7 the the DT cord-325324-kh2aal5n 156 8 target target NN cord-325324-kh2aal5n 156 9 might may MD cord-325324-kh2aal5n 156 10 be be VB cord-325324-kh2aal5n 156 11 better well JJR cord-325324-kh2aal5n 156 12 against against IN cord-325324-kh2aal5n 156 13 the the DT cord-325324-kh2aal5n 156 14 spike spike NN cord-325324-kh2aal5n 156 15 protein protein NN cord-325324-kh2aal5n 156 16 of of IN cord-325324-kh2aal5n 156 17 SARS SARS NNP cord-325324-kh2aal5n 156 18 - - HYPH cord-325324-kh2aal5n 156 19 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 156 20 than than IN cord-325324-kh2aal5n 156 21 ACE2 ACE2 NNP cord-325324-kh2aal5n 156 22 because because IN cord-325324-kh2aal5n 156 23 targeting target VBG cord-325324-kh2aal5n 156 24 ACE2 ACE2 NNP cord-325324-kh2aal5n 156 25 per per FW cord-325324-kh2aal5n 156 26 se se FW cord-325324-kh2aal5n 156 27 might may MD cord-325324-kh2aal5n 156 28 impose impose VB cord-325324-kh2aal5n 156 29 a a DT cord-325324-kh2aal5n 156 30 detrimental detrimental JJ cord-325324-kh2aal5n 156 31 effect effect NN cord-325324-kh2aal5n 156 32 on on IN cord-325324-kh2aal5n 156 33 the the DT cord-325324-kh2aal5n 156 34 patient patient NN cord-325324-kh2aal5n 156 35 who who WP cord-325324-kh2aal5n 156 36 has have VBZ cord-325324-kh2aal5n 156 37 the the DT cord-325324-kh2aal5n 156 38 underlying underlie VBG cord-325324-kh2aal5n 156 39 diseases disease NNS cord-325324-kh2aal5n 156 40 . . . cord-325324-kh2aal5n 157 1 The the DT cord-325324-kh2aal5n 157 2 effects effect NNS cord-325324-kh2aal5n 157 3 of of IN cord-325324-kh2aal5n 157 4 variants variant NNS cord-325324-kh2aal5n 157 5 on on IN cord-325324-kh2aal5n 157 6 binding bind VBG cord-325324-kh2aal5n 157 7 affinity affinity NN cord-325324-kh2aal5n 157 8 were be VBD cord-325324-kh2aal5n 157 9 predicted predict VBN cord-325324-kh2aal5n 157 10 using use VBG cord-325324-kh2aal5n 157 11 mcsm mcsm NN cord-325324-kh2aal5n 157 12 - - HYPH cord-325324-kh2aal5n 157 13 ppi2 ppi2 NNP cord-325324-kh2aal5n 157 14 ( ( -LRB- cord-325324-kh2aal5n 157 15 http://biosig.unimelb.edu.au/mcsm_ppi2/ http://biosig.unimelb.edu.au/mcsm_ppi2/ NNP cord-325324-kh2aal5n 157 16 ) ) -RRB- cord-325324-kh2aal5n 157 17 . . . cord-325324-kh2aal5n 158 1 Mutation mutation NN cord-325324-kh2aal5n 158 2 pathogenicity pathogenicity NN cord-325324-kh2aal5n 158 3 predictions prediction NNS cord-325324-kh2aal5n 158 4 were be VBD cord-325324-kh2aal5n 158 5 extracted extract VBN cord-325324-kh2aal5n 158 6 from from IN cord-325324-kh2aal5n 158 7 dbNSFP dbNSFP NNP cord-325324-kh2aal5n 158 8 ( ( -LRB- cord-325324-kh2aal5n 158 9 https://sites.google.com/site/jpopgen/dbNSFP https://sites.google.com/site/jpopgen/dbNSFP NNP cord-325324-kh2aal5n 158 10 ) ) -RRB- cord-325324-kh2aal5n 158 11 . . . cord-325324-kh2aal5n 159 1 Allele allele NN cord-325324-kh2aal5n 159 2 counts count VBZ cord-325324-kh2aal5n 159 3 in in IN cord-325324-kh2aal5n 159 4 different different JJ cord-325324-kh2aal5n 159 5 populations population NNS cord-325324-kh2aal5n 159 6 were be VBD cord-325324-kh2aal5n 159 7 downloaded download VBN cord-325324-kh2aal5n 159 8 from from IN cord-325324-kh2aal5n 159 9 gnomAD gnomAD NNP cord-325324-kh2aal5n 159 10 ( ( -LRB- cord-325324-kh2aal5n 159 11 https://gnomad.broadinstitute.org/ https://gnomad.broadinstitute.org/ ADD cord-325324-kh2aal5n 159 12 ) ) -RRB- cord-325324-kh2aal5n 159 13 Figure figure NN cord-325324-kh2aal5n 159 14 1 1 CD cord-325324-kh2aal5n 159 15 . . . cord-325324-kh2aal5n 160 1 Two two CD cord-325324-kh2aal5n 160 2 theories theory NNS cord-325324-kh2aal5n 160 3 to to TO cord-325324-kh2aal5n 160 4 explain explain VB cord-325324-kh2aal5n 160 5 the the DT cord-325324-kh2aal5n 160 6 severity severity NN cord-325324-kh2aal5n 160 7 of of IN cord-325324-kh2aal5n 160 8 COVID-19 COVID-19 NNP cord-325324-kh2aal5n 160 9 : : SYM cord-325324-kh2aal5n 160 10 1 1 CD cord-325324-kh2aal5n 160 11 . . . cord-325324-kh2aal5n 161 1 ACE2 ACE2 NNP cord-325324-kh2aal5n 161 2 enhancing enhance VBG cord-325324-kh2aal5n 161 3 viral viral JJ cord-325324-kh2aal5n 161 4 infection infection NN cord-325324-kh2aal5n 161 5 , , , cord-325324-kh2aal5n 161 6 and and CC cord-325324-kh2aal5n 161 7 2 2 CD cord-325324-kh2aal5n 161 8 . . . cord-325324-kh2aal5n 162 1 Viral viral JJ cord-325324-kh2aal5n 162 2 aggravating aggravate VBG cord-325324-kh2aal5n 162 3 existing exist VBG cord-325324-kh2aal5n 162 4 diseases disease NNS cord-325324-kh2aal5n 162 5 . . . cord-325324-kh2aal5n 163 1 ACE ace NN cord-325324-kh2aal5n 163 2 catalyzes catalyze VBZ cord-325324-kh2aal5n 163 3 the the DT cord-325324-kh2aal5n 163 4 conversion conversion NN cord-325324-kh2aal5n 163 5 of of IN cord-325324-kh2aal5n 163 6 angiotensin angiotensin NN cord-325324-kh2aal5n 163 7 I -PRON- PRP cord-325324-kh2aal5n 163 8 to to IN cord-325324-kh2aal5n 163 9 angiotensin angiotensin NN cord-325324-kh2aal5n 163 10 II II NNP cord-325324-kh2aal5n 163 11 , , , cord-325324-kh2aal5n 163 12 a a DT cord-325324-kh2aal5n 163 13 vasoconstrictor vasoconstrictor NN cord-325324-kh2aal5n 163 14 . . . cord-325324-kh2aal5n 164 1 Angiotensin Angiotensin NNP cord-325324-kh2aal5n 164 2 II II NNP cord-325324-kh2aal5n 164 3 is be VBZ cord-325324-kh2aal5n 164 4 converted convert VBN cord-325324-kh2aal5n 164 5 by by IN cord-325324-kh2aal5n 164 6 ACE2 ACE2 NNP cord-325324-kh2aal5n 164 7 to to IN cord-325324-kh2aal5n 164 8 Angiotensin-(1 Angiotensin-(1 NNP cord-325324-kh2aal5n 164 9 - - HYPH cord-325324-kh2aal5n 164 10 7 7 CD cord-325324-kh2aal5n 164 11 ) ) -RRB- cord-325324-kh2aal5n 164 12 , , , cord-325324-kh2aal5n 164 13 a a DT cord-325324-kh2aal5n 164 14 vasodilator vasodilator NN cord-325324-kh2aal5n 164 15 . . . cord-325324-kh2aal5n 165 1 Theory theory NN cord-325324-kh2aal5n 165 2 1 1 CD cord-325324-kh2aal5n 165 3 suggests suggest VBZ cord-325324-kh2aal5n 165 4 that that IN cord-325324-kh2aal5n 165 5 using use VBG cord-325324-kh2aal5n 165 6 ACEI ACEI NNP cord-325324-kh2aal5n 165 7 / / SYM cord-325324-kh2aal5n 165 8 ARB ARB NNP cord-325324-kh2aal5n 165 9 increases increase VBZ cord-325324-kh2aal5n 165 10 ACE2 ACE2 NNP cord-325324-kh2aal5n 165 11 , , , cord-325324-kh2aal5n 165 12 which which WDT cord-325324-kh2aal5n 165 13 further further RB cord-325324-kh2aal5n 165 14 enhances enhance VBZ cord-325324-kh2aal5n 165 15 viral viral JJ cord-325324-kh2aal5n 165 16 infection infection NN cord-325324-kh2aal5n 165 17 . . . cord-325324-kh2aal5n 166 1 Theory theory NN cord-325324-kh2aal5n 166 2 2 2 CD cord-325324-kh2aal5n 166 3 suggests suggest VBZ cord-325324-kh2aal5n 166 4 that that IN cord-325324-kh2aal5n 166 5 ACE2 ACE2 NNP cord-325324-kh2aal5n 166 6 can can MD cord-325324-kh2aal5n 166 7 be be VB cord-325324-kh2aal5n 166 8 either either CC cord-325324-kh2aal5n 166 9 exhausted exhausted JJ cord-325324-kh2aal5n 166 10 or or CC cord-325324-kh2aal5n 166 11 functionally functionally RB cord-325324-kh2aal5n 166 12 inhibited inhibit VBN cord-325324-kh2aal5n 166 13 by by IN cord-325324-kh2aal5n 166 14 S1 S1 NNP cord-325324-kh2aal5n 166 15 so so IN cord-325324-kh2aal5n 166 16 that that IN cord-325324-kh2aal5n 166 17 more more JJR cord-325324-kh2aal5n 166 18 angiotensin angiotensin NN cord-325324-kh2aal5n 166 19 II II NNP cord-325324-kh2aal5n 166 20 and and CC cord-325324-kh2aal5n 166 21 less less JJR cord-325324-kh2aal5n 166 22 Angiotensin-(1 Angiotensin-(1 NNP cord-325324-kh2aal5n 166 23 - - HYPH cord-325324-kh2aal5n 166 24 7 7 CD cord-325324-kh2aal5n 166 25 ) ) -RRB- cord-325324-kh2aal5n 166 26 are be VBP cord-325324-kh2aal5n 166 27 produced produce VBN cord-325324-kh2aal5n 166 28 , , , cord-325324-kh2aal5n 166 29 which which WDT cord-325324-kh2aal5n 166 30 would would MD cord-325324-kh2aal5n 166 31 aggravate aggravate VB cord-325324-kh2aal5n 166 32 underlying underlie VBG cord-325324-kh2aal5n 166 33 diseases disease NNS cord-325324-kh2aal5n 166 34 . . . cord-325324-kh2aal5n 167 1 ( ( -LRB- cord-325324-kh2aal5n 167 2 green green NNP cord-325324-kh2aal5n 167 3 ) ) -RRB- cord-325324-kh2aal5n 167 4 , , , cord-325324-kh2aal5n 167 5 SARS SARS NNP cord-325324-kh2aal5n 167 6 - - HYPH cord-325324-kh2aal5n 167 7 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 167 8 spike spike NN cord-325324-kh2aal5n 167 9 receptor receptor NN cord-325324-kh2aal5n 167 10 - - HYPH cord-325324-kh2aal5n 167 11 binding bind VBG cord-325324-kh2aal5n 167 12 domain domain NN cord-325324-kh2aal5n 167 13 ( ( -LRB- cord-325324-kh2aal5n 167 14 RBD RBD NNP cord-325324-kh2aal5n 167 15 , , , cord-325324-kh2aal5n 167 16 yellow yellow JJ cord-325324-kh2aal5n 167 17 orange orange NN cord-325324-kh2aal5n 167 18 ) ) -RRB- cord-325324-kh2aal5n 167 19 and and CC cord-325324-kh2aal5n 167 20 receptor receptor NN cord-325324-kh2aal5n 167 21 - - HYPH cord-325324-kh2aal5n 167 22 binding bind VBG cord-325324-kh2aal5n 167 23 motif motif NN cord-325324-kh2aal5n 167 24 ( ( -LRB- cord-325324-kh2aal5n 167 25 RBM RBM NNP cord-325324-kh2aal5n 167 26 : : : cord-325324-kh2aal5n 167 27 brown brown NNP cord-325324-kh2aal5n 167 28 ) ) -RRB- cord-325324-kh2aal5n 167 29 were be VBD cord-325324-kh2aal5n 167 30 shown show VBN cord-325324-kh2aal5n 167 31 as as IN cord-325324-kh2aal5n 167 32 cartoons cartoon NNS cord-325324-kh2aal5n 167 33 . . . cord-325324-kh2aal5n 168 1 ACE2 ACE2 NNP cord-325324-kh2aal5n 168 2 contacted contact VBD cord-325324-kh2aal5n 168 3 residues residue NNS cord-325324-kh2aal5n 168 4 , , , cord-325324-kh2aal5n 168 5 including include VBG cord-325324-kh2aal5n 168 6 S19 S19 NNP cord-325324-kh2aal5n 168 7 ( ( -LRB- cord-325324-kh2aal5n 168 8 purple purple NN cord-325324-kh2aal5n 168 9 ) ) -RRB- cord-325324-kh2aal5n 168 10 , , , cord-325324-kh2aal5n 168 11 T27 T27 NNP cord-325324-kh2aal5n 168 12 ( ( -LRB- cord-325324-kh2aal5n 168 13 red red NNP cord-325324-kh2aal5n 168 14 ) ) -RRB- cord-325324-kh2aal5n 168 15 , , , cord-325324-kh2aal5n 168 16 E35 E35 NNP cord-325324-kh2aal5n 168 17 and and CC cord-325324-kh2aal5n 168 18 E27 E27 NNP cord-325324-kh2aal5n 168 19 ( ( -LRB- cord-325324-kh2aal5n 168 20 magenta magenta NN cord-325324-kh2aal5n 168 21 ) ) -RRB- cord-325324-kh2aal5n 168 22 , , , cord-325324-kh2aal5n 168 23 M82 M82 NNP cord-325324-kh2aal5n 168 24 ( ( -LRB- cord-325324-kh2aal5n 168 25 orange orange NNP cord-325324-kh2aal5n 168 26 ) ) -RRB- cord-325324-kh2aal5n 168 27 and and CC cord-325324-kh2aal5n 168 28 D355 D355 NNP cord-325324-kh2aal5n 168 29 ( ( -LRB- cord-325324-kh2aal5n 168 30 hot hot JJ cord-325324-kh2aal5n 168 31 pink pink NN cord-325324-kh2aal5n 168 32 ) ) -RRB- cord-325324-kh2aal5n 168 33 , , , cord-325324-kh2aal5n 168 34 were be VBD cord-325324-kh2aal5n 168 35 displayed display VBN cord-325324-kh2aal5n 168 36 as as IN cord-325324-kh2aal5n 168 37 sticks stick NNS cord-325324-kh2aal5n 168 38 . . . cord-325324-kh2aal5n 169 1 The the DT cord-325324-kh2aal5n 169 2 image image NN cord-325324-kh2aal5n 169 3 was be VBD cord-325324-kh2aal5n 169 4 generated generate VBN cord-325324-kh2aal5n 169 5 using use VBG cord-325324-kh2aal5n 169 6 PyMOL PyMOL NNP cord-325324-kh2aal5n 169 7 ( ( -LRB- cord-325324-kh2aal5n 169 8 http://www.pymol.org/ http://www.pymol.org/ NN cord-325324-kh2aal5n 169 9 ) ) -RRB- cord-325324-kh2aal5n 169 10 based base VBN cord-325324-kh2aal5n 169 11 on on IN cord-325324-kh2aal5n 169 12 PDB PDB NNP cord-325324-kh2aal5n 169 13 ID ID NNP cord-325324-kh2aal5n 169 14 : : : cord-325324-kh2aal5n 170 1 6LZG 6lzg UH cord-325324-kh2aal5n 170 2 . . . cord-325324-kh2aal5n 170 3 _SP cord-325324-kh2aal5n 171 1 Genomic genomic JJ cord-325324-kh2aal5n 171 2 characterization characterization NN cord-325324-kh2aal5n 171 3 of of IN cord-325324-kh2aal5n 171 4 severe severe JJ cord-325324-kh2aal5n 171 5 acute acute JJ cord-325324-kh2aal5n 171 6 respiratory respiratory JJ cord-325324-kh2aal5n 171 7 syndrome syndrome NN cord-325324-kh2aal5n 171 8 - - HYPH cord-325324-kh2aal5n 171 9 related relate VBN cord-325324-kh2aal5n 171 10 coronavirus coronavirus NN cord-325324-kh2aal5n 171 11 in in IN cord-325324-kh2aal5n 171 12 European european JJ cord-325324-kh2aal5n 171 13 bats bat NNS cord-325324-kh2aal5n 171 14 and and CC cord-325324-kh2aal5n 171 15 classification classification NN cord-325324-kh2aal5n 171 16 of of IN cord-325324-kh2aal5n 171 17 coronaviruses coronaviruse NNS cord-325324-kh2aal5n 171 18 based base VBN cord-325324-kh2aal5n 171 19 on on IN cord-325324-kh2aal5n 171 20 partial partial JJ cord-325324-kh2aal5n 171 21 RNA RNA NNP cord-325324-kh2aal5n 171 22 - - HYPH cord-325324-kh2aal5n 171 23 dependent dependent JJ cord-325324-kh2aal5n 171 24 RNA RNA NNP cord-325324-kh2aal5n 171 25 polymerase polymerase NN cord-325324-kh2aal5n 171 26 gene gene NN cord-325324-kh2aal5n 171 27 sequences sequence NNS cord-325324-kh2aal5n 171 28 Genomic genomic JJ cord-325324-kh2aal5n 171 29 classification classification NN cord-325324-kh2aal5n 171 30 using use VBG cord-325324-kh2aal5n 171 31 an an DT cord-325324-kh2aal5n 171 32 informationbased informationbase VBN cord-325324-kh2aal5n 171 33 similarity similarity NN cord-325324-kh2aal5n 171 34 index index NN cord-325324-kh2aal5n 171 35 : : : cord-325324-kh2aal5n 171 36 application application NN cord-325324-kh2aal5n 171 37 to to IN cord-325324-kh2aal5n 171 38 the the DT cord-325324-kh2aal5n 171 39 SARS SARS NNP cord-325324-kh2aal5n 171 40 coronavirus coronavirus NN cord-325324-kh2aal5n 171 41 Coronaviruses Coronaviruses NNPS cord-325324-kh2aal5n 171 42 : : : cord-325324-kh2aal5n 171 43 an an DT cord-325324-kh2aal5n 171 44 overview overview NN cord-325324-kh2aal5n 171 45 of of IN cord-325324-kh2aal5n 171 46 their -PRON- PRP$ cord-325324-kh2aal5n 171 47 replication replication NN cord-325324-kh2aal5n 171 48 and and CC cord-325324-kh2aal5n 171 49 pathogenesis pathogenesis NN cord-325324-kh2aal5n 172 1 The the DT cord-325324-kh2aal5n 172 2 " " `` cord-325324-kh2aal5n 172 3 common common JJ cord-325324-kh2aal5n 172 4 cold cold NN cord-325324-kh2aal5n 172 5 " " '' cord-325324-kh2aal5n 172 6 in in IN cord-325324-kh2aal5n 172 7 frail frail JJ cord-325324-kh2aal5n 172 8 older old JJR cord-325324-kh2aal5n 172 9 persons person NNS cord-325324-kh2aal5n 172 10 : : : cord-325324-kh2aal5n 172 11 impact impact NN cord-325324-kh2aal5n 172 12 of of IN cord-325324-kh2aal5n 172 13 rhinovirus rhinovirus NN cord-325324-kh2aal5n 172 14 and and CC cord-325324-kh2aal5n 172 15 coronavirus coronavirus NN cord-325324-kh2aal5n 172 16 in in IN cord-325324-kh2aal5n 172 17 a a DT cord-325324-kh2aal5n 172 18 senior senior JJ cord-325324-kh2aal5n 172 19 daycare daycare NN cord-325324-kh2aal5n 172 20 center center NN cord-325324-kh2aal5n 172 21 A a DT cord-325324-kh2aal5n 172 22 human human JJ cord-325324-kh2aal5n 172 23 coronavirus coronavirus NN cord-325324-kh2aal5n 172 24 responsible responsible JJ cord-325324-kh2aal5n 172 25 for for IN cord-325324-kh2aal5n 172 26 the the DT cord-325324-kh2aal5n 172 27 common common JJ cord-325324-kh2aal5n 172 28 cold cold NN cord-325324-kh2aal5n 172 29 massively massively RB cord-325324-kh2aal5n 172 30 kills kill VBZ cord-325324-kh2aal5n 172 31 dendritic dendritic JJ cord-325324-kh2aal5n 172 32 cells cell NNS cord-325324-kh2aal5n 172 33 but but CC cord-325324-kh2aal5n 172 34 not not RB cord-325324-kh2aal5n 172 35 monocytes monocyte VBZ cord-325324-kh2aal5n 173 1 Coronavirus Coronavirus NNP cord-325324-kh2aal5n 173 2 Infections Infections NNPS cord-325324-kh2aal5n 173 3 - - : cord-325324-kh2aal5n 173 4 More More JJR cord-325324-kh2aal5n 173 5 Than than IN cord-325324-kh2aal5n 173 6 Just just RB cord-325324-kh2aal5n 173 7 the the DT cord-325324-kh2aal5n 173 8 Common Common NNP cord-325324-kh2aal5n 173 9 Cold Cold NNP cord-325324-kh2aal5n 173 10 Novel Novel NNP cord-325324-kh2aal5n 173 11 coronavirus coronavirus NN cord-325324-kh2aal5n 174 1 COVID-19 covid-19 VB cord-325324-kh2aal5n 174 2 : : : cord-325324-kh2aal5n 174 3 an an DT cord-325324-kh2aal5n 174 4 overview overview NN cord-325324-kh2aal5n 174 5 for for IN cord-325324-kh2aal5n 174 6 emergency emergency NN cord-325324-kh2aal5n 174 7 clinicians clinician NNS cord-325324-kh2aal5n 175 1 Novel novel JJ cord-325324-kh2aal5n 175 2 2019 2019 CD cord-325324-kh2aal5n 175 3 coronavirus coronavirus NN cord-325324-kh2aal5n 175 4 SARS SARS NNP cord-325324-kh2aal5n 175 5 - - HYPH cord-325324-kh2aal5n 175 6 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 175 7 ( ( -LRB- cord-325324-kh2aal5n 175 8 COVID-19 COVID-19 NNP cord-325324-kh2aal5n 175 9 ) ) -RRB- cord-325324-kh2aal5n 175 10 : : : cord-325324-kh2aal5n 176 1 An an DT cord-325324-kh2aal5n 176 2 updated update VBN cord-325324-kh2aal5n 176 3 overview overview NN cord-325324-kh2aal5n 176 4 for for IN cord-325324-kh2aal5n 176 5 emergency emergency NN cord-325324-kh2aal5n 176 6 clinicians clinician NNS cord-325324-kh2aal5n 177 1 The the DT cord-325324-kh2aal5n 177 2 outbreak outbreak NN cord-325324-kh2aal5n 177 3 of of IN cord-325324-kh2aal5n 177 4 COVID-19 COVID-19 NNP cord-325324-kh2aal5n 177 5 : : : cord-325324-kh2aal5n 177 6 An an DT cord-325324-kh2aal5n 177 7 overview overview NN cord-325324-kh2aal5n 177 8 Structure Structure NNP cord-325324-kh2aal5n 177 9 , , , cord-325324-kh2aal5n 177 10 Function Function NNP cord-325324-kh2aal5n 177 11 , , , cord-325324-kh2aal5n 177 12 and and CC cord-325324-kh2aal5n 177 13 Evolution evolution NN cord-325324-kh2aal5n 177 14 of of IN cord-325324-kh2aal5n 177 15 Coronavirus Coronavirus NNP cord-325324-kh2aal5n 177 16 Spike Spike NNP cord-325324-kh2aal5n 177 17 Proteins protein NNS cord-325324-kh2aal5n 177 18 Programmed program VBD cord-325324-kh2aal5n 177 19 ribosomal ribosomal NN cord-325324-kh2aal5n 177 20 frameshifting frameshifte VBG cord-325324-kh2aal5n 177 21 in in IN cord-325324-kh2aal5n 177 22 decoding decode VBG cord-325324-kh2aal5n 177 23 the the DT cord-325324-kh2aal5n 177 24 SARS SARS NNP cord-325324-kh2aal5n 177 25 - - HYPH cord-325324-kh2aal5n 177 26 CoV CoV NNP cord-325324-kh2aal5n 177 27 genome genome NN cord-325324-kh2aal5n 178 1 The the DT cord-325324-kh2aal5n 178 2 structure structure NN cord-325324-kh2aal5n 178 3 of of IN cord-325324-kh2aal5n 178 4 a a DT cord-325324-kh2aal5n 178 5 rigorously rigorously RB cord-325324-kh2aal5n 178 6 conserved conserve VBN cord-325324-kh2aal5n 178 7 RNA RNA NNP cord-325324-kh2aal5n 178 8 element element NN cord-325324-kh2aal5n 178 9 within within IN cord-325324-kh2aal5n 178 10 the the DT cord-325324-kh2aal5n 178 11 SARS SARS NNP cord-325324-kh2aal5n 178 12 virus virus NN cord-325324-kh2aal5n 178 13 genome genome NN cord-325324-kh2aal5n 178 14 Soluble Soluble NNP cord-325324-kh2aal5n 178 15 angiotensin angiotensin NN cord-325324-kh2aal5n 178 16 - - HYPH cord-325324-kh2aal5n 178 17 converting convert VBG cord-325324-kh2aal5n 178 18 enzyme enzyme NN cord-325324-kh2aal5n 178 19 2 2 CD cord-325324-kh2aal5n 178 20 : : : cord-325324-kh2aal5n 178 21 a a DT cord-325324-kh2aal5n 178 22 potential potential JJ cord-325324-kh2aal5n 178 23 approach approach NN cord-325324-kh2aal5n 178 24 for for IN cord-325324-kh2aal5n 178 25 coronavirus coronavirus NN cord-325324-kh2aal5n 178 26 infection infection NN cord-325324-kh2aal5n 178 27 therapy therapy NN cord-325324-kh2aal5n 178 28 Cleavage cleavage NN cord-325324-kh2aal5n 178 29 and and CC cord-325324-kh2aal5n 178 30 activation activation NN cord-325324-kh2aal5n 178 31 of of IN cord-325324-kh2aal5n 178 32 the the DT cord-325324-kh2aal5n 178 33 severe severe JJ cord-325324-kh2aal5n 178 34 acute acute JJ cord-325324-kh2aal5n 178 35 respiratory respiratory JJ cord-325324-kh2aal5n 178 36 syndrome syndrome NN cord-325324-kh2aal5n 178 37 coronavirus coronavirus NN cord-325324-kh2aal5n 178 38 spike spike NN cord-325324-kh2aal5n 178 39 protein protein NN cord-325324-kh2aal5n 178 40 by by IN cord-325324-kh2aal5n 178 41 human human JJ cord-325324-kh2aal5n 178 42 airway airway NN cord-325324-kh2aal5n 178 43 trypsin trypsin NN cord-325324-kh2aal5n 178 44 - - HYPH cord-325324-kh2aal5n 178 45 like like JJ cord-325324-kh2aal5n 178 46 protease protease NN cord-325324-kh2aal5n 178 47 TMPRSS2 tmprss2 NN cord-325324-kh2aal5n 178 48 and and CC cord-325324-kh2aal5n 178 49 ADAM17 ADAM17 NNP cord-325324-kh2aal5n 178 50 cleave cleave VB cord-325324-kh2aal5n 178 51 ACE2 ACE2 NNP cord-325324-kh2aal5n 178 52 differentially differentially RB cord-325324-kh2aal5n 178 53 and and CC cord-325324-kh2aal5n 178 54 only only JJ cord-325324-kh2aal5n 178 55 proteolysis proteolysis NN cord-325324-kh2aal5n 178 56 by by IN cord-325324-kh2aal5n 178 57 TMPRSS2 TMPRSS2 NNP cord-325324-kh2aal5n 178 58 augments augment VBZ cord-325324-kh2aal5n 178 59 entry entry NN cord-325324-kh2aal5n 178 60 driven drive VBN cord-325324-kh2aal5n 178 61 by by IN cord-325324-kh2aal5n 178 62 the the DT cord-325324-kh2aal5n 178 63 severe severe JJ cord-325324-kh2aal5n 178 64 acute acute JJ cord-325324-kh2aal5n 178 65 respiratory respiratory JJ cord-325324-kh2aal5n 178 66 syndrome syndrome NN cord-325324-kh2aal5n 178 67 coronavirus coronavirus NN cord-325324-kh2aal5n 178 68 spike spike NN cord-325324-kh2aal5n 178 69 protein protein NN cord-325324-kh2aal5n 178 70 ACE2 ACE2 NNP cord-325324-kh2aal5n 178 71 : : : cord-325324-kh2aal5n 179 1 The the DT cord-325324-kh2aal5n 179 2 key key JJ cord-325324-kh2aal5n 179 3 Molecule Molecule NNP cord-325324-kh2aal5n 179 4 for for IN cord-325324-kh2aal5n 179 5 Understanding understand VBG cord-325324-kh2aal5n 179 6 the the DT cord-325324-kh2aal5n 179 7 Pathophysiology Pathophysiology NNP cord-325324-kh2aal5n 179 8 of of IN cord-325324-kh2aal5n 179 9 Severe severe JJ cord-325324-kh2aal5n 179 10 and and CC cord-325324-kh2aal5n 179 11 Critical Critical NNP cord-325324-kh2aal5n 179 12 Conditions Conditions NNPS cord-325324-kh2aal5n 179 13 of of IN cord-325324-kh2aal5n 179 14 COVID-19 COVID-19 NNP cord-325324-kh2aal5n 179 15 : : : cord-325324-kh2aal5n 179 16 Demon Demon NNP cord-325324-kh2aal5n 179 17 or or CC cord-325324-kh2aal5n 179 18 Angel Angel NNP cord-325324-kh2aal5n 179 19 ? ? . cord-325324-kh2aal5n 180 1 Viruses virus NNS cord-325324-kh2aal5n 180 2 12 12 CD cord-325324-kh2aal5n 180 3 Feng Feng NNP cord-325324-kh2aal5n 180 4 Z. Z. NNP cord-325324-kh2aal5n 180 5 2020 2020 CD cord-325324-kh2aal5n 180 6 . . . cord-325324-kh2aal5n 181 1 Early early JJ cord-325324-kh2aal5n 181 2 Transmission Transmission NNP cord-325324-kh2aal5n 181 3 Dynamics Dynamics NNPS cord-325324-kh2aal5n 181 4 in in IN cord-325324-kh2aal5n 181 5 Wuhan Wuhan NNP cord-325324-kh2aal5n 181 6 , , , cord-325324-kh2aal5n 181 7 China China NNP cord-325324-kh2aal5n 181 8 , , , cord-325324-kh2aal5n 181 9 of of IN cord-325324-kh2aal5n 181 10 Novel Novel NNP cord-325324-kh2aal5n 181 11 Coronavirus Coronavirus NNP cord-325324-kh2aal5n 181 12 - - HYPH cord-325324-kh2aal5n 181 13 Infected Infected NNP cord-325324-kh2aal5n 181 14 Pneumonia Pneumonia NNP cord-325324-kh2aal5n 181 15 Clinical clinical JJ cord-325324-kh2aal5n 181 16 characteristics characteristic NNS cord-325324-kh2aal5n 181 17 of of IN cord-325324-kh2aal5n 181 18 225 225 CD cord-325324-kh2aal5n 181 19 patients patient NNS cord-325324-kh2aal5n 181 20 with with IN cord-325324-kh2aal5n 181 21 COVID-19 covid-19 CD cord-325324-kh2aal5n 181 22 in in IN cord-325324-kh2aal5n 181 23 a a DT cord-325324-kh2aal5n 181 24 tertiary tertiary JJ cord-325324-kh2aal5n 181 25 Hospital Hospital NNP cord-325324-kh2aal5n 181 26 near near IN cord-325324-kh2aal5n 181 27 Wuhan Wuhan NNP cord-325324-kh2aal5n 181 28 Clinical Clinical NNP cord-325324-kh2aal5n 181 29 features feature NNS cord-325324-kh2aal5n 181 30 and and CC cord-325324-kh2aal5n 181 31 short short JJ cord-325324-kh2aal5n 181 32 - - HYPH cord-325324-kh2aal5n 181 33 term term NN cord-325324-kh2aal5n 181 34 outcomes outcome NNS cord-325324-kh2aal5n 181 35 of of IN cord-325324-kh2aal5n 181 36 221 221 CD cord-325324-kh2aal5n 181 37 patients patient NNS cord-325324-kh2aal5n 181 38 with with IN cord-325324-kh2aal5n 181 39 COVID-19 COVID-19 NNP cord-325324-kh2aal5n 181 40 in in IN cord-325324-kh2aal5n 181 41 Wuhan Wuhan NNP cord-325324-kh2aal5n 182 1 The the DT cord-325324-kh2aal5n 182 2 first first JJ cord-325324-kh2aal5n 182 3 two two CD cord-325324-kh2aal5n 182 4 cases case NNS cord-325324-kh2aal5n 182 5 of of IN cord-325324-kh2aal5n 182 6 2019-nCoV 2019-ncov CD cord-325324-kh2aal5n 182 7 in in IN cord-325324-kh2aal5n 182 8 Italy Italy NNP cord-325324-kh2aal5n 182 9 : : : cord-325324-kh2aal5n 182 10 Where where WRB cord-325324-kh2aal5n 182 11 they -PRON- PRP cord-325324-kh2aal5n 182 12 come come VBP cord-325324-kh2aal5n 182 13 from from IN cord-325324-kh2aal5n 182 14 A a DT cord-325324-kh2aal5n 182 15 pneumonia pneumonia NN cord-325324-kh2aal5n 182 16 outbreak outbreak NN cord-325324-kh2aal5n 182 17 associated associate VBN cord-325324-kh2aal5n 182 18 with with IN cord-325324-kh2aal5n 182 19 a a DT cord-325324-kh2aal5n 182 20 new new JJ cord-325324-kh2aal5n 182 21 coronavirus coronavirus NN cord-325324-kh2aal5n 182 22 of of IN cord-325324-kh2aal5n 182 23 probable probable JJ cord-325324-kh2aal5n 182 24 bat bat NN cord-325324-kh2aal5n 182 25 origin origin NN cord-325324-kh2aal5n 182 26 Probable probable JJ cord-325324-kh2aal5n 182 27 Pangolin Pangolin NNP cord-325324-kh2aal5n 182 28 Origin Origin NNP cord-325324-kh2aal5n 182 29 of of IN cord-325324-kh2aal5n 182 30 SARS SARS NNP cord-325324-kh2aal5n 182 31 - - HYPH cord-325324-kh2aal5n 182 32 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 183 1 Associated associate VBN cord-325324-kh2aal5n 183 2 with with IN cord-325324-kh2aal5n 183 3 the the DT cord-325324-kh2aal5n 183 4 COVID-19 COVID-19 NNP cord-325324-kh2aal5n 183 5 Outbreak Outbreak NNP cord-325324-kh2aal5n 183 6 Genetic Genetic NNP cord-325324-kh2aal5n 183 7 evolution evolution NN cord-325324-kh2aal5n 183 8 analysis analysis NN cord-325324-kh2aal5n 183 9 of of IN cord-325324-kh2aal5n 183 10 2019 2019 CD cord-325324-kh2aal5n 183 11 novel novel JJ cord-325324-kh2aal5n 183 12 coronavirus coronavirus NN cord-325324-kh2aal5n 183 13 and and CC cord-325324-kh2aal5n 183 14 coronavirus coronavirus NN cord-325324-kh2aal5n 183 15 from from IN cord-325324-kh2aal5n 183 16 other other JJ cord-325324-kh2aal5n 183 17 species specie NNS cord-325324-kh2aal5n 184 1 Evolutionary evolutionary JJ cord-325324-kh2aal5n 184 2 history history NN cord-325324-kh2aal5n 184 3 , , , cord-325324-kh2aal5n 184 4 potential potential JJ cord-325324-kh2aal5n 184 5 intermediate intermediate JJ cord-325324-kh2aal5n 184 6 animal animal NN cord-325324-kh2aal5n 184 7 host host NN cord-325324-kh2aal5n 184 8 , , , cord-325324-kh2aal5n 184 9 and and CC cord-325324-kh2aal5n 184 10 cross cross JJ cord-325324-kh2aal5n 184 11 - - JJ cord-325324-kh2aal5n 184 12 species species JJ cord-325324-kh2aal5n 184 13 analyses analysis NNS cord-325324-kh2aal5n 184 14 of of IN cord-325324-kh2aal5n 184 15 SARS SARS NNP cord-325324-kh2aal5n 184 16 - - HYPH cord-325324-kh2aal5n 184 17 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 184 18 Systematic systematic JJ cord-325324-kh2aal5n 184 19 Comparison comparison NN cord-325324-kh2aal5n 184 20 of of IN cord-325324-kh2aal5n 184 21 Two Two NNP cord-325324-kh2aal5n 184 22 Animal Animal NNP cord-325324-kh2aal5n 184 23 - - HYPH cord-325324-kh2aal5n 184 24 to to IN cord-325324-kh2aal5n 184 25 - - HYPH cord-325324-kh2aal5n 184 26 Human Human NNP cord-325324-kh2aal5n 184 27 Transmitted Transmitted NNP cord-325324-kh2aal5n 184 28 Human Human NNP cord-325324-kh2aal5n 184 29 Coronaviruses Coronaviruses NNPS cord-325324-kh2aal5n 184 30 : : : cord-325324-kh2aal5n 185 1 SARS SARS NNP cord-325324-kh2aal5n 185 2 - - HYPH cord-325324-kh2aal5n 185 3 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 185 4 and and CC cord-325324-kh2aal5n 185 5 SARS SARS NNP cord-325324-kh2aal5n 185 6 - - HYPH cord-325324-kh2aal5n 185 7 CoV CoV NNP cord-325324-kh2aal5n 185 8 Susceptibility Susceptibility NNP cord-325324-kh2aal5n 185 9 of of IN cord-325324-kh2aal5n 185 10 ferrets ferret NNS cord-325324-kh2aal5n 185 11 , , , cord-325324-kh2aal5n 185 12 cats cat NNS cord-325324-kh2aal5n 185 13 , , , cord-325324-kh2aal5n 185 14 dogs dog NNS cord-325324-kh2aal5n 185 15 , , , cord-325324-kh2aal5n 185 16 and and CC cord-325324-kh2aal5n 185 17 other other JJ cord-325324-kh2aal5n 185 18 domesticated domesticated JJ cord-325324-kh2aal5n 185 19 animals animal NNS cord-325324-kh2aal5n 185 20 to to IN cord-325324-kh2aal5n 185 21 SARScoronavirus SARScoronavirus NNP cord-325324-kh2aal5n 185 22 2 2 CD cord-325324-kh2aal5n 185 23 High High NNP cord-325324-kh2aal5n 185 24 Contagiousness Contagiousness NNP cord-325324-kh2aal5n 185 25 and and CC cord-325324-kh2aal5n 185 26 Rapid Rapid NNP cord-325324-kh2aal5n 185 27 Spread Spread NNP cord-325324-kh2aal5n 185 28 of of IN cord-325324-kh2aal5n 185 29 Severe severe JJ cord-325324-kh2aal5n 185 30 Acute acute JJ cord-325324-kh2aal5n 185 31 Respiratory Respiratory NNP cord-325324-kh2aal5n 185 32 Syndrome Syndrome NNP cord-325324-kh2aal5n 185 33 Coronavirus Coronavirus NNP cord-325324-kh2aal5n 185 34 2 2 CD cord-325324-kh2aal5n 185 35 Reconstruction Reconstruction NNP cord-325324-kh2aal5n 185 36 of of IN cord-325324-kh2aal5n 185 37 the the DT cord-325324-kh2aal5n 185 38 full full JJ cord-325324-kh2aal5n 185 39 transmission transmission NN cord-325324-kh2aal5n 185 40 dynamics dynamic NNS cord-325324-kh2aal5n 185 41 of of IN cord-325324-kh2aal5n 185 42 COVID-19 COVID-19 NNP cord-325324-kh2aal5n 185 43 in in IN cord-325324-kh2aal5n 185 44 Wuhan Wuhan NNP cord-325324-kh2aal5n 185 45 Weathering Weathering NNP cord-325324-kh2aal5n 185 46 the the DT cord-325324-kh2aal5n 185 47 pandemic pandemic NN cord-325324-kh2aal5n 185 48 : : : cord-325324-kh2aal5n 186 1 How how WRB cord-325324-kh2aal5n 186 2 the the DT cord-325324-kh2aal5n 186 3 Caribbean Caribbean NNP cord-325324-kh2aal5n 186 4 Basin Basin NNP cord-325324-kh2aal5n 186 5 can can MD cord-325324-kh2aal5n 186 6 use use VB cord-325324-kh2aal5n 186 7 viral viral JJ cord-325324-kh2aal5n 186 8 and and CC cord-325324-kh2aal5n 186 9 environmental environmental JJ cord-325324-kh2aal5n 186 10 patterns pattern NNS cord-325324-kh2aal5n 186 11 to to TO cord-325324-kh2aal5n 186 12 predict predict VB cord-325324-kh2aal5n 186 13 , , , cord-325324-kh2aal5n 186 14 prepare prepare VB cord-325324-kh2aal5n 186 15 and and CC cord-325324-kh2aal5n 186 16 respond respond VB cord-325324-kh2aal5n 186 17 to to TO cord-325324-kh2aal5n 186 18 COVID-19 covid-19 VB cord-325324-kh2aal5n 186 19 MPH1,3 MPH1,3 NNP cord-325324-kh2aal5n 186 20 ; ; : cord-325324-kh2aal5n 186 21 Rachel Rachel NNP cord-325324-kh2aal5n 186 22 Holstein Holstein NNP cord-325324-kh2aal5n 186 23 , , , cord-325324-kh2aal5n 186 24 MPH1,4 MPH1,4 NNP cord-325324-kh2aal5n 186 25 ; ; : cord-325324-kh2aal5n 186 26 Mila Mila NNP cord-325324-kh2aal5n 186 27 Prill Prill NNP cord-325324-kh2aal5n 186 28 , , , cord-325324-kh2aal5n 186 29 MSPH1 msph1 NN cord-325324-kh2aal5n 186 30 Hospitalization hospitalization NN cord-325324-kh2aal5n 186 31 Rates Rates NNPS cord-325324-kh2aal5n 186 32 and and CC cord-325324-kh2aal5n 186 33 Characteristics characteristic NNS cord-325324-kh2aal5n 186 34 of of IN cord-325324-kh2aal5n 186 35 Patients patient NNS cord-325324-kh2aal5n 186 36 Hospitalized hospitalize VBN cord-325324-kh2aal5n 186 37 with with IN cord-325324-kh2aal5n 186 38 Laboratory Laboratory NNP cord-325324-kh2aal5n 186 39 - - HYPH cord-325324-kh2aal5n 186 40 Confirmed confirm VBN cord-325324-kh2aal5n 186 41 Coronavirus Coronavirus NNP cord-325324-kh2aal5n 186 42 Disease Disease NNP cord-325324-kh2aal5n 186 43 2019 2019 CD cord-325324-kh2aal5n 186 44 -COVID -covid NN cord-325324-kh2aal5n 186 45 - - HYPH cord-325324-kh2aal5n 186 46 NET net NN cord-325324-kh2aal5n 186 47 , , , cord-325324-kh2aal5n 186 48 14 14 CD cord-325324-kh2aal5n 186 49 States States NNP cord-325324-kh2aal5n 186 50 Familial familial JJ cord-325324-kh2aal5n 186 51 hypercholesterolemia hypercholesterolemia NN cord-325324-kh2aal5n 186 52 and and CC cord-325324-kh2aal5n 186 53 COVID-19 covid-19 NN cord-325324-kh2aal5n 186 54 : : : cord-325324-kh2aal5n 186 55 triggering trigger VBG cord-325324-kh2aal5n 186 56 of of IN cord-325324-kh2aal5n 186 57 increased increased JJ cord-325324-kh2aal5n 186 58 sustained sustained JJ cord-325324-kh2aal5n 186 59 cardiovascular cardiovascular JJ cord-325324-kh2aal5n 186 60 risk risk NN cord-325324-kh2aal5n 186 61 Clinical clinical JJ cord-325324-kh2aal5n 186 62 characteristics characteristic NNS cord-325324-kh2aal5n 186 63 of of IN cord-325324-kh2aal5n 186 64 25 25 CD cord-325324-kh2aal5n 186 65 death death NN cord-325324-kh2aal5n 186 66 cases case NNS cord-325324-kh2aal5n 186 67 with with IN cord-325324-kh2aal5n 186 68 COVID-19 COVID-19 NNP cord-325324-kh2aal5n 186 69 : : : cord-325324-kh2aal5n 186 70 a a DT cord-325324-kh2aal5n 186 71 retrospective retrospective JJ cord-325324-kh2aal5n 186 72 review review NN cord-325324-kh2aal5n 186 73 of of IN cord-325324-kh2aal5n 186 74 medical medical JJ cord-325324-kh2aal5n 186 75 records record NNS cord-325324-kh2aal5n 186 76 in in IN cord-325324-kh2aal5n 186 77 a a DT cord-325324-kh2aal5n 186 78 single single JJ cord-325324-kh2aal5n 186 79 medical medical JJ cord-325324-kh2aal5n 186 80 center center NN cord-325324-kh2aal5n 187 1 The the DT cord-325324-kh2aal5n 187 2 Science Science NNP cord-325324-kh2aal5n 187 3 Underlying underlying NN cord-325324-kh2aal5n 188 1 COVID-19 covid-19 VB cord-325324-kh2aal5n 188 2 : : : cord-325324-kh2aal5n 188 3 Implications implication NNS cord-325324-kh2aal5n 188 4 for for IN cord-325324-kh2aal5n 188 5 the the DT cord-325324-kh2aal5n 188 6 Cardiovascular Cardiovascular NNP cord-325324-kh2aal5n 188 7 System System NNP cord-325324-kh2aal5n 188 8 COVID-19 COVID-19 NNP cord-325324-kh2aal5n 188 9 and and CC cord-325324-kh2aal5n 188 10 African African NNP cord-325324-kh2aal5n 188 11 Americans Americans NNPS cord-325324-kh2aal5n 188 12 Role role NN cord-325324-kh2aal5n 188 13 of of IN cord-325324-kh2aal5n 188 14 the the DT cord-325324-kh2aal5n 188 15 ACE2 ACE2 NNP cord-325324-kh2aal5n 189 1 / / NFP cord-325324-kh2aal5n 190 1 Angiotensin angiotensin NN cord-325324-kh2aal5n 190 2 1 1 CD cord-325324-kh2aal5n 190 3 - - SYM cord-325324-kh2aal5n 190 4 7 7 CD cord-325324-kh2aal5n 190 5 Axis Axis NNP cord-325324-kh2aal5n 190 6 of of IN cord-325324-kh2aal5n 190 7 the the DT cord-325324-kh2aal5n 190 8 Renin Renin NNP cord-325324-kh2aal5n 190 9 - - HYPH cord-325324-kh2aal5n 190 10 Angiotensin Angiotensin NNP cord-325324-kh2aal5n 190 11 System System NNP cord-325324-kh2aal5n 190 12 in in IN cord-325324-kh2aal5n 190 13 Heart Heart NNP cord-325324-kh2aal5n 190 14 Failure failure NN cord-325324-kh2aal5n 191 1 The the DT cord-325324-kh2aal5n 191 2 Renin Renin NNP cord-325324-kh2aal5n 191 3 Angiotensin Angiotensin NNP cord-325324-kh2aal5n 191 4 System System NNP cord-325324-kh2aal5n 191 5 and and CC cord-325324-kh2aal5n 191 6 Bipolar Bipolar NNP cord-325324-kh2aal5n 191 7 Disorder Disorder NNP cord-325324-kh2aal5n 191 8 : : : cord-325324-kh2aal5n 191 9 A a DT cord-325324-kh2aal5n 191 10 Systematic Systematic NNP cord-325324-kh2aal5n 191 11 Review Review NNP cord-325324-kh2aal5n 191 12 Renin renin NN cord-325324-kh2aal5n 191 13 - - HYPH cord-325324-kh2aal5n 191 14 angiotensinaldosterone angiotensinaldosterone NN cord-325324-kh2aal5n 191 15 system system NN cord-325324-kh2aal5n 191 16 and and CC cord-325324-kh2aal5n 191 17 migraine migraine NN cord-325324-kh2aal5n 191 18 : : : cord-325324-kh2aal5n 191 19 a a DT cord-325324-kh2aal5n 191 20 systematic systematic JJ cord-325324-kh2aal5n 191 21 review review NN cord-325324-kh2aal5n 191 22 of of IN cord-325324-kh2aal5n 191 23 human human JJ cord-325324-kh2aal5n 191 24 studies study NNS cord-325324-kh2aal5n 191 25 The the DT cord-325324-kh2aal5n 191 26 renin renin NN cord-325324-kh2aal5n 191 27 - - HYPH cord-325324-kh2aal5n 191 28 angiotensin angiotensin NN cord-325324-kh2aal5n 191 29 system system NN cord-325324-kh2aal5n 191 30 blockers blocker NNS cord-325324-kh2aal5n 191 31 and and CC cord-325324-kh2aal5n 191 32 survival survival NN cord-325324-kh2aal5n 191 33 in in IN cord-325324-kh2aal5n 191 34 digestive digestive JJ cord-325324-kh2aal5n 191 35 system system NN cord-325324-kh2aal5n 191 36 malignancies malignancy NNS cord-325324-kh2aal5n 191 37 : : : cord-325324-kh2aal5n 191 38 A a DT cord-325324-kh2aal5n 191 39 systematic systematic JJ cord-325324-kh2aal5n 191 40 review review NN cord-325324-kh2aal5n 191 41 and and CC cord-325324-kh2aal5n 191 42 meta meta NN cord-325324-kh2aal5n 191 43 - - HYPH cord-325324-kh2aal5n 191 44 analysis analysis NN cord-325324-kh2aal5n 191 45 Effects effect NNS cord-325324-kh2aal5n 191 46 of of IN cord-325324-kh2aal5n 191 47 Angiotensin Angiotensin NNP cord-325324-kh2aal5n 191 48 - - HYPH cord-325324-kh2aal5n 191 49 Converting convert VBG cord-325324-kh2aal5n 191 50 Enzyme Enzyme NNP cord-325324-kh2aal5n 191 51 Inhibitors Inhibitors NNP cord-325324-kh2aal5n 191 52 on on IN cord-325324-kh2aal5n 191 53 Arterial Arterial NNP cord-325324-kh2aal5n 191 54 Stiffness Stiffness NNP cord-325324-kh2aal5n 191 55 : : : cord-325324-kh2aal5n 191 56 A a DT cord-325324-kh2aal5n 191 57 Systematic Systematic NNP cord-325324-kh2aal5n 191 58 Review Review NNP cord-325324-kh2aal5n 191 59 and and CC cord-325324-kh2aal5n 191 60 Meta Meta NNP cord-325324-kh2aal5n 191 61 - - HYPH cord-325324-kh2aal5n 191 62 Analysis Analysis NNP cord-325324-kh2aal5n 191 63 of of IN cord-325324-kh2aal5n 191 64 Randomized Randomized NNP cord-325324-kh2aal5n 191 65 Controlled Controlled NNP cord-325324-kh2aal5n 191 66 Trials Trials NNPS cord-325324-kh2aal5n 191 67 Angiotensin Angiotensin NNP cord-325324-kh2aal5n 191 68 - - HYPH cord-325324-kh2aal5n 191 69 converting convert VBG cord-325324-kh2aal5n 191 70 enzyme enzyme NN cord-325324-kh2aal5n 191 71 gene gene NN cord-325324-kh2aal5n 191 72 insertion insertion NN cord-325324-kh2aal5n 191 73 / / SYM cord-325324-kh2aal5n 191 74 deletion deletion NN cord-325324-kh2aal5n 191 75 polymorphism polymorphism NN cord-325324-kh2aal5n 191 76 and and CC cord-325324-kh2aal5n 191 77 susceptibility susceptibility NN cord-325324-kh2aal5n 191 78 to to IN cord-325324-kh2aal5n 191 79 psoriasis psoriasis NN cord-325324-kh2aal5n 191 80 : : : cord-325324-kh2aal5n 191 81 a a DT cord-325324-kh2aal5n 191 82 systematic systematic JJ cord-325324-kh2aal5n 191 83 review review NN cord-325324-kh2aal5n 191 84 and and CC cord-325324-kh2aal5n 191 85 meta meta NNP cord-325324-kh2aal5n 191 86 - - HYPH cord-325324-kh2aal5n 191 87 analysis analysis NN cord-325324-kh2aal5n 191 88 ACE2 ACE2 NNP cord-325324-kh2aal5n 191 89 of of IN cord-325324-kh2aal5n 191 90 the the DT cord-325324-kh2aal5n 191 91 heart heart NN cord-325324-kh2aal5n 191 92 : : : cord-325324-kh2aal5n 192 1 From from IN cord-325324-kh2aal5n 192 2 angiotensin angiotensin NN cord-325324-kh2aal5n 192 3 I -PRON- PRP cord-325324-kh2aal5n 192 4 to to IN cord-325324-kh2aal5n 192 5 angiotensin angiotensin NN cord-325324-kh2aal5n 192 6 ( ( -LRB- cord-325324-kh2aal5n 192 7 1 1 CD cord-325324-kh2aal5n 192 8 - - SYM cord-325324-kh2aal5n 192 9 7 7 CD cord-325324-kh2aal5n 192 10 ) ) -RRB- cord-325324-kh2aal5n 192 11 Angiotensin-(1 angiotensin-(1 NN cord-325324-kh2aal5n 192 12 - - HYPH cord-325324-kh2aal5n 192 13 9 9 CD cord-325324-kh2aal5n 192 14 ) ) -RRB- cord-325324-kh2aal5n 193 1 : : : cord-325324-kh2aal5n 193 2 New new JJ cord-325324-kh2aal5n 193 3 Promise promise NN cord-325324-kh2aal5n 193 4 for for IN cord-325324-kh2aal5n 193 5 Post Post NNP cord-325324-kh2aal5n 193 6 - - NNP cord-325324-kh2aal5n 193 7 Infarct Infarct NNP cord-325324-kh2aal5n 193 8 Functional Functional NNP cord-325324-kh2aal5n 193 9 Therapy Therapy NNP cord-325324-kh2aal5n 193 10 -9 -9 ADD cord-325324-kh2aal5n 193 11 ) ) -RRB- cord-325324-kh2aal5n 194 1 Preserves preserve NNS cord-325324-kh2aal5n 194 2 Left leave VBN cord-325324-kh2aal5n 194 3 Ventricular Ventricular NNP cord-325324-kh2aal5n 194 4 Systolic Systolic NNP cord-325324-kh2aal5n 194 5 Function Function NNP cord-325324-kh2aal5n 195 1 After after IN cord-325324-kh2aal5n 195 2 Myocardial Myocardial NNP cord-325324-kh2aal5n 195 3 Infarction Infarction NNP cord-325324-kh2aal5n 195 4 Angiotensin-(1 Angiotensin-(1 NNP cord-325324-kh2aal5n 195 5 - - HYPH cord-325324-kh2aal5n 195 6 9 9 CD cord-325324-kh2aal5n 195 7 ) ) -RRB- cord-325324-kh2aal5n 195 8 prevents prevent VBZ cord-325324-kh2aal5n 195 9 cardiomyocyte cardiomyocyte JJ cord-325324-kh2aal5n 195 10 hypertrophy hypertrophy NN cord-325324-kh2aal5n 195 11 by by IN cord-325324-kh2aal5n 195 12 controlling control VBG cord-325324-kh2aal5n 195 13 mitochondrial mitochondrial JJ cord-325324-kh2aal5n 195 14 dynamics dynamic NNS cord-325324-kh2aal5n 195 15 via via IN cord-325324-kh2aal5n 195 16 miR-129 miR-129 NNS cord-325324-kh2aal5n 195 17 - - HYPH cord-325324-kh2aal5n 195 18 3p 3p CD cord-325324-kh2aal5n 195 19 / / SYM cord-325324-kh2aal5n 195 20 PKIA PKIA NNP cord-325324-kh2aal5n 195 21 pathway pathway NN cord-325324-kh2aal5n 195 22 Antihypertensive antihypertensive JJ cord-325324-kh2aal5n 195 23 drugs drug NNS cord-325324-kh2aal5n 195 24 and and CC cord-325324-kh2aal5n 195 25 risk risk NN cord-325324-kh2aal5n 195 26 of of IN cord-325324-kh2aal5n 195 27 COVID-19 COVID-19 NNP cord-325324-kh2aal5n 195 28 ? ? . cord-325324-kh2aal5n 196 1 -Authors -author NNS cord-325324-kh2aal5n 196 2 ' ' POS cord-325324-kh2aal5n 196 3 reply reply NN cord-325324-kh2aal5n 196 4 Are be VBP cord-325324-kh2aal5n 196 5 patients patient NNS cord-325324-kh2aal5n 196 6 with with IN cord-325324-kh2aal5n 196 7 hypertension hypertension NN cord-325324-kh2aal5n 196 8 and and CC cord-325324-kh2aal5n 196 9 diabetes diabetes NN cord-325324-kh2aal5n 196 10 mellitus mellitus NN cord-325324-kh2aal5n 196 11 at at IN cord-325324-kh2aal5n 196 12 increased increase VBN cord-325324-kh2aal5n 196 13 risk risk NN cord-325324-kh2aal5n 196 14 for for IN cord-325324-kh2aal5n 196 15 COVID-19 covid-19 JJ cord-325324-kh2aal5n 196 16 infection infection NN cord-325324-kh2aal5n 196 17 ? ? . cord-325324-kh2aal5n 197 1 Renin renin NN cord-325324-kh2aal5n 197 2 - - HYPH cord-325324-kh2aal5n 197 3 angiotensin angiotensin NN cord-325324-kh2aal5n 197 4 system system NN cord-325324-kh2aal5n 197 5 inhibitors inhibitor NNS cord-325324-kh2aal5n 197 6 improve improve VBP cord-325324-kh2aal5n 197 7 the the DT cord-325324-kh2aal5n 197 8 clinical clinical JJ cord-325324-kh2aal5n 197 9 outcomes outcome NNS cord-325324-kh2aal5n 197 10 of of IN cord-325324-kh2aal5n 197 11 COVID-19 covid-19 JJ cord-325324-kh2aal5n 197 12 patients patient NNS cord-325324-kh2aal5n 197 13 with with IN cord-325324-kh2aal5n 197 14 hypertension hypertension NN cord-325324-kh2aal5n 197 15 Neprilysin Neprilysin NNP cord-325324-kh2aal5n 197 16 inhibitor inhibitor NN cord-325324-kh2aal5n 197 17 - - HYPH cord-325324-kh2aal5n 197 18 angiotensin angiotensin NN cord-325324-kh2aal5n 197 19 II II NNP cord-325324-kh2aal5n 197 20 receptor receptor NN cord-325324-kh2aal5n 197 21 blocker blocker NN cord-325324-kh2aal5n 197 22 combination combination NN cord-325324-kh2aal5n 197 23 ( ( -LRB- cord-325324-kh2aal5n 197 24 sacubitril sacubitril NNP cord-325324-kh2aal5n 197 25 / / SYM cord-325324-kh2aal5n 197 26 valsartan valsartan NNP cord-325324-kh2aal5n 197 27 ) ) -RRB- cord-325324-kh2aal5n 197 28 : : : cord-325324-kh2aal5n 197 29 rationale rationale NN cord-325324-kh2aal5n 197 30 for for IN cord-325324-kh2aal5n 197 31 adoption adoption NN cord-325324-kh2aal5n 197 32 in in IN cord-325324-kh2aal5n 197 33 SARS SARS NNP cord-325324-kh2aal5n 197 34 - - HYPH cord-325324-kh2aal5n 197 35 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 197 36 patients patient NNS cord-325324-kh2aal5n 197 37 Angiotensin Angiotensin NNP cord-325324-kh2aal5n 197 38 receptor receptor NN cord-325324-kh2aal5n 197 39 blockers blocker NNS cord-325324-kh2aal5n 197 40 as as IN cord-325324-kh2aal5n 197 41 tentative tentative JJ cord-325324-kh2aal5n 197 42 SARS SARS NNP cord-325324-kh2aal5n 197 43 - - HYPH cord-325324-kh2aal5n 197 44 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 197 45 therapeutics therapeutic NNS cord-325324-kh2aal5n 197 46 Hypertension hypertension NN cord-325324-kh2aal5n 197 47 , , , cord-325324-kh2aal5n 197 48 the the DT cord-325324-kh2aal5n 197 49 renin renin NN cord-325324-kh2aal5n 197 50 - - HYPH cord-325324-kh2aal5n 197 51 angiotensin angiotensin NN cord-325324-kh2aal5n 197 52 system system NN cord-325324-kh2aal5n 197 53 , , , cord-325324-kh2aal5n 197 54 and and CC cord-325324-kh2aal5n 197 55 the the DT cord-325324-kh2aal5n 197 56 risk risk NN cord-325324-kh2aal5n 197 57 of of IN cord-325324-kh2aal5n 197 58 lower low JJR cord-325324-kh2aal5n 197 59 respiratory respiratory JJ cord-325324-kh2aal5n 197 60 tract tract NN cord-325324-kh2aal5n 197 61 infections infection NNS cord-325324-kh2aal5n 197 62 and and CC cord-325324-kh2aal5n 197 63 lung lung NN cord-325324-kh2aal5n 197 64 injury injury NN cord-325324-kh2aal5n 197 65 : : : cord-325324-kh2aal5n 197 66 implications implication NNS cord-325324-kh2aal5n 197 67 for for IN cord-325324-kh2aal5n 197 68 COVID-19 COVID-19 NNP cord-325324-kh2aal5n 197 69 Sound Sound NNP cord-325324-kh2aal5n 197 70 Science Science NNP cord-325324-kh2aal5n 197 71 before before IN cord-325324-kh2aal5n 197 72 Quick Quick NNP cord-325324-kh2aal5n 197 73 Judgement Judgement NNP cord-325324-kh2aal5n 197 74 Regarding regard VBG cord-325324-kh2aal5n 197 75 RAS RAS NNP cord-325324-kh2aal5n 197 76 Blockade Blockade NNP cord-325324-kh2aal5n 197 77 in in IN cord-325324-kh2aal5n 197 78 COVID-19 COVID-19 NNP cord-325324-kh2aal5n 197 79 Renin Renin NNP cord-325324-kh2aal5n 197 80 - - HYPH cord-325324-kh2aal5n 197 81 Angiotensin Angiotensin NNP cord-325324-kh2aal5n 197 82 System System NNP cord-325324-kh2aal5n 197 83 Blockers Blockers NNP cord-325324-kh2aal5n 197 84 and and CC cord-325324-kh2aal5n 197 85 the the DT cord-325324-kh2aal5n 197 86 COVID-19 COVID-19 NNP cord-325324-kh2aal5n 197 87 Pandemic Pandemic NNP cord-325324-kh2aal5n 197 88 : : : cord-325324-kh2aal5n 197 89 At at IN cord-325324-kh2aal5n 197 90 Present Present NNP cord-325324-kh2aal5n 197 91 There there EX cord-325324-kh2aal5n 197 92 Is be VBZ cord-325324-kh2aal5n 197 93 No no DT cord-325324-kh2aal5n 197 94 Evidence evidence NN cord-325324-kh2aal5n 197 95 to to TO cord-325324-kh2aal5n 197 96 Abandon abandon VB cord-325324-kh2aal5n 197 97 Renin Renin NNP cord-325324-kh2aal5n 197 98 - - HYPH cord-325324-kh2aal5n 197 99 Angiotensin Angiotensin NNP cord-325324-kh2aal5n 197 100 System system NN cord-325324-kh2aal5n 197 101 Blockers Blockers NNP cord-325324-kh2aal5n 197 102 Tissue tissue NN cord-325324-kh2aal5n 197 103 distribution distribution NN cord-325324-kh2aal5n 197 104 of of IN cord-325324-kh2aal5n 197 105 ACE2 ACE2 NNP cord-325324-kh2aal5n 197 106 protein protein NN cord-325324-kh2aal5n 197 107 , , , cord-325324-kh2aal5n 197 108 the the DT cord-325324-kh2aal5n 197 109 functional functional JJ cord-325324-kh2aal5n 197 110 receptor receptor NN cord-325324-kh2aal5n 197 111 for for IN cord-325324-kh2aal5n 197 112 SARS SARS NNP cord-325324-kh2aal5n 197 113 coronavirus coronavirus NN cord-325324-kh2aal5n 197 114 . . . cord-325324-kh2aal5n 198 1 A a DT cord-325324-kh2aal5n 198 2 first first JJ cord-325324-kh2aal5n 198 3 step step NN cord-325324-kh2aal5n 198 4 in in IN cord-325324-kh2aal5n 198 5 understanding understand VBG cord-325324-kh2aal5n 198 6 SARS SARS NNP cord-325324-kh2aal5n 198 7 pathogenesis pathogenesis NN cord-325324-kh2aal5n 198 8 Renal Renal NNP cord-325324-kh2aal5n 198 9 ACE2 ACE2 NNP cord-325324-kh2aal5n 198 10 expression expression NN cord-325324-kh2aal5n 198 11 in in IN cord-325324-kh2aal5n 198 12 human human JJ cord-325324-kh2aal5n 198 13 kidney kidney NN cord-325324-kh2aal5n 198 14 disease disease NN cord-325324-kh2aal5n 199 1 A a DT cord-325324-kh2aal5n 200 1 novel novel JJ cord-325324-kh2aal5n 200 2 angiotensinconverting angiotensinconverting NN cord-325324-kh2aal5n 200 3 enzyme enzyme NN cord-325324-kh2aal5n 200 4 - - HYPH cord-325324-kh2aal5n 200 5 related relate VBN cord-325324-kh2aal5n 200 6 carboxypeptidase carboxypeptidase NN cord-325324-kh2aal5n 200 7 ( ( -LRB- cord-325324-kh2aal5n 200 8 ACE2 ACE2 NNP cord-325324-kh2aal5n 200 9 ) ) -RRB- cord-325324-kh2aal5n 200 10 converts convert VBZ cord-325324-kh2aal5n 200 11 angiotensin angiotensin NN cord-325324-kh2aal5n 200 12 I -PRON- PRP cord-325324-kh2aal5n 200 13 to to IN cord-325324-kh2aal5n 200 14 angiotensin angiotensin NN cord-325324-kh2aal5n 200 15 1 1 CD cord-325324-kh2aal5n 200 16 - - SYM cord-325324-kh2aal5n 200 17 9 9 CD cord-325324-kh2aal5n 200 18 Recombinant Recombinant NNP cord-325324-kh2aal5n 200 19 Human Human NNP cord-325324-kh2aal5n 200 20 ACE2 ACE2 NNP cord-325324-kh2aal5n 200 21 and and CC cord-325324-kh2aal5n 200 22 the the DT cord-325324-kh2aal5n 200 23 Angiotensin Angiotensin NNP cord-325324-kh2aal5n 200 24 1 1 CD cord-325324-kh2aal5n 200 25 - - SYM cord-325324-kh2aal5n 200 26 7 7 CD cord-325324-kh2aal5n 200 27 Axis Axis NNP cord-325324-kh2aal5n 200 28 as as IN cord-325324-kh2aal5n 200 29 Potential potential JJ cord-325324-kh2aal5n 200 30 New New NNP cord-325324-kh2aal5n 200 31 Therapies Therapies NNPS cord-325324-kh2aal5n 200 32 for for IN cord-325324-kh2aal5n 200 33 Heart Heart NNP cord-325324-kh2aal5n 200 34 Failure failure NN cord-325324-kh2aal5n 201 1 Angiotensin angiotensin NN cord-325324-kh2aal5n 201 2 - - HYPH cord-325324-kh2aal5n 201 3 Converting convert VBG cord-325324-kh2aal5n 201 4 Enzyme Enzyme NNP cord-325324-kh2aal5n 201 5 2 2 CD cord-325324-kh2aal5n 201 6 Metabolizes Metabolizes NNPS cord-325324-kh2aal5n 201 7 and and CC cord-325324-kh2aal5n 201 8 Partially partially RB cord-325324-kh2aal5n 201 9 Inactivates Inactivates NNPS cord-325324-kh2aal5n 201 10 Pyr Pyr NNP cord-325324-kh2aal5n 201 11 - - HYPH cord-325324-kh2aal5n 201 12 Apelin-13 Apelin-13 NNS cord-325324-kh2aal5n 201 13 and and CC cord-325324-kh2aal5n 201 14 Apelin-17 apelin-17 NN cord-325324-kh2aal5n 202 1 : : : cord-325324-kh2aal5n 202 2 Physiological physiological JJ cord-325324-kh2aal5n 202 3 Effects effect NNS cord-325324-kh2aal5n 202 4 in in IN cord-325324-kh2aal5n 202 5 the the DT cord-325324-kh2aal5n 202 6 Cardiovascular Cardiovascular NNP cord-325324-kh2aal5n 202 7 System System NNP cord-325324-kh2aal5n 202 8 Increased increase VBN cord-325324-kh2aal5n 202 9 angiotensin-(1 angiotensin-(1 NN cord-325324-kh2aal5n 202 10 - - : cord-325324-kh2aal5n 202 11 7)-forming 7)-forming CD cord-325324-kh2aal5n 202 12 activity activity NN cord-325324-kh2aal5n 202 13 in in IN cord-325324-kh2aal5n 202 14 failing fail VBG cord-325324-kh2aal5n 202 15 human human JJ cord-325324-kh2aal5n 202 16 heart heart NN cord-325324-kh2aal5n 202 17 ventricles ventricle NNS cord-325324-kh2aal5n 202 18 : : : cord-325324-kh2aal5n 202 19 evidence evidence NN cord-325324-kh2aal5n 202 20 for for IN cord-325324-kh2aal5n 202 21 upregulation upregulation NN cord-325324-kh2aal5n 202 22 of of IN cord-325324-kh2aal5n 202 23 the the DT cord-325324-kh2aal5n 202 24 angiotensin angiotensin NN cord-325324-kh2aal5n 202 25 - - HYPH cord-325324-kh2aal5n 202 26 converting convert VBG cord-325324-kh2aal5n 202 27 enzyme enzyme NN cord-325324-kh2aal5n 202 28 Homologue Homologue NNP cord-325324-kh2aal5n 203 1 ACE2 ACE2 NNP cord-325324-kh2aal5n 203 2 A a DT cord-325324-kh2aal5n 203 3 crucial crucial JJ cord-325324-kh2aal5n 203 4 role role NN cord-325324-kh2aal5n 203 5 of of IN cord-325324-kh2aal5n 203 6 angiotensin angiotensin NN cord-325324-kh2aal5n 203 7 converting convert VBG cord-325324-kh2aal5n 203 8 enzyme enzyme NN cord-325324-kh2aal5n 203 9 2 2 CD cord-325324-kh2aal5n 203 10 ( ( -LRB- cord-325324-kh2aal5n 203 11 ACE2 ACE2 NNP cord-325324-kh2aal5n 203 12 ) ) -RRB- cord-325324-kh2aal5n 203 13 in in IN cord-325324-kh2aal5n 203 14 SARS SARS NNP cord-325324-kh2aal5n 203 15 coronavirus coronavirus NN cord-325324-kh2aal5n 203 16 - - HYPH cord-325324-kh2aal5n 203 17 induced induce VBN cord-325324-kh2aal5n 203 18 lung lung NN cord-325324-kh2aal5n 203 19 injury injury NN cord-325324-kh2aal5n 203 20 Angiotensin Angiotensin NNP cord-325324-kh2aal5n 203 21 Converting Converting NNP cord-325324-kh2aal5n 203 22 Enzyme Enzyme NNP cord-325324-kh2aal5n 203 23 2 2 CD cord-325324-kh2aal5n 203 24 and and CC cord-325324-kh2aal5n 203 25 Angiotensin Angiotensin NNP cord-325324-kh2aal5n 203 26 ( ( -LRB- cord-325324-kh2aal5n 203 27 1 1 CD cord-325324-kh2aal5n 203 28 - - SYM cord-325324-kh2aal5n 203 29 7 7 CD cord-325324-kh2aal5n 203 30 ) ) -RRB- cord-325324-kh2aal5n 203 31 axis axis NN cord-325324-kh2aal5n 203 32 in in IN cord-325324-kh2aal5n 203 33 Pulmonary Pulmonary NNP cord-325324-kh2aal5n 203 34 Arterial Arterial NNP cord-325324-kh2aal5n 203 35 Hypertension Hypertension NNP cord-325324-kh2aal5n 203 36 Ang Ang NNP cord-325324-kh2aal5n 203 37 II II NNP cord-325324-kh2aal5n 203 38 ( ( -LRB- cord-325324-kh2aal5n 203 39 Angiotensin Angiotensin NNP cord-325324-kh2aal5n 203 40 II II NNP cord-325324-kh2aal5n 203 41 ) ) -RRB- cord-325324-kh2aal5n 203 42 Conversion conversion NN cord-325324-kh2aal5n 203 43 to to IN cord-325324-kh2aal5n 203 44 Angiotensin-(1 Angiotensin-(1 NNP cord-325324-kh2aal5n 203 45 - - HYPH cord-325324-kh2aal5n 203 46 7 7 CD cord-325324-kh2aal5n 203 47 ) ) -RRB- cord-325324-kh2aal5n 203 48 in in IN cord-325324-kh2aal5n 203 49 the the DT cord-325324-kh2aal5n 203 50 Circulation Circulation NNP cord-325324-kh2aal5n 203 51 Is be VBZ cord-325324-kh2aal5n 203 52 POP pop NN cord-325324-kh2aal5n 203 53 ( ( -LRB- cord-325324-kh2aal5n 203 54 Prolyloligopeptidase)-Dependent Prolyloligopeptidase)-Dependent NNP cord-325324-kh2aal5n 203 55 and and CC cord-325324-kh2aal5n 203 56 ACE2 ACE2 NNP cord-325324-kh2aal5n 204 1 ( ( -LRB- cord-325324-kh2aal5n 204 2 Angiotensin Angiotensin NNP cord-325324-kh2aal5n 204 3 - - HYPH cord-325324-kh2aal5n 204 4 Converting convert VBG cord-325324-kh2aal5n 204 5 Enzyme Enzyme NNP cord-325324-kh2aal5n 204 6 2)-Independent 2)-independent CD cord-325324-kh2aal5n 204 7 Angiotensin Angiotensin NNP cord-325324-kh2aal5n 204 8 - - HYPH cord-325324-kh2aal5n 204 9 converting convert VBG cord-325324-kh2aal5n 204 10 enzyme enzyme NN cord-325324-kh2aal5n 204 11 2 2 CD cord-325324-kh2aal5n 204 12 is be VBZ cord-325324-kh2aal5n 204 13 a a DT cord-325324-kh2aal5n 204 14 functional functional JJ cord-325324-kh2aal5n 204 15 receptor receptor NN cord-325324-kh2aal5n 204 16 for for IN cord-325324-kh2aal5n 204 17 the the DT cord-325324-kh2aal5n 204 18 SARS SARS NNP cord-325324-kh2aal5n 204 19 coronavirus coronavirus NN cord-325324-kh2aal5n 204 20 Structure Structure NNP cord-325324-kh2aal5n 204 21 of of IN cord-325324-kh2aal5n 204 22 SARS SARS NNP cord-325324-kh2aal5n 204 23 coronavirus coronavirus NN cord-325324-kh2aal5n 204 24 spike spike NN cord-325324-kh2aal5n 204 25 receptorbinding receptorbinde VBG cord-325324-kh2aal5n 204 26 domain domain NN cord-325324-kh2aal5n 204 27 complexed complexe VBN cord-325324-kh2aal5n 204 28 with with IN cord-325324-kh2aal5n 204 29 receptor receptor NN cord-325324-kh2aal5n 204 30 Human human JJ cord-325324-kh2aal5n 204 31 coronavirus coronavirus NN cord-325324-kh2aal5n 204 32 NL63 NL63 NNP cord-325324-kh2aal5n 204 33 employs employ VBZ cord-325324-kh2aal5n 204 34 the the DT cord-325324-kh2aal5n 204 35 severe severe JJ cord-325324-kh2aal5n 204 36 acute acute JJ cord-325324-kh2aal5n 204 37 respiratory respiratory JJ cord-325324-kh2aal5n 204 38 syndrome syndrome NN cord-325324-kh2aal5n 204 39 coronavirus coronavirus NN cord-325324-kh2aal5n 204 40 receptor receptor NN cord-325324-kh2aal5n 204 41 for for IN cord-325324-kh2aal5n 204 42 cellular cellular JJ cord-325324-kh2aal5n 204 43 entry entry NN cord-325324-kh2aal5n 205 1 Understanding understand VBG cord-325324-kh2aal5n 205 2 Human Human NNP cord-325324-kh2aal5n 205 3 Coronavirus Coronavirus NNP cord-325324-kh2aal5n 205 4 HCoV HCoV NNP cord-325324-kh2aal5n 205 5 - - : cord-325324-kh2aal5n 205 6 NL63 NL63 NNP cord-325324-kh2aal5n 205 7 Receptor Receptor NNP cord-325324-kh2aal5n 205 8 Recognition Recognition NNP cord-325324-kh2aal5n 205 9 by by IN cord-325324-kh2aal5n 205 10 the the DT cord-325324-kh2aal5n 205 11 Novel Novel NNP cord-325324-kh2aal5n 205 12 Coronavirus Coronavirus NNP cord-325324-kh2aal5n 205 13 from from IN cord-325324-kh2aal5n 205 14 Wuhan Wuhan NNP cord-325324-kh2aal5n 205 15 : : : cord-325324-kh2aal5n 205 16 an an DT cord-325324-kh2aal5n 205 17 Analysis Analysis NNP cord-325324-kh2aal5n 205 18 Based base VBN cord-325324-kh2aal5n 205 19 on on IN cord-325324-kh2aal5n 205 20 Decade decade NN cord-325324-kh2aal5n 205 21 - - HYPH cord-325324-kh2aal5n 205 22 Long Long NNP cord-325324-kh2aal5n 205 23 Structural Structural NNP cord-325324-kh2aal5n 205 24 Studies Studies NNPS cord-325324-kh2aal5n 205 25 of of IN cord-325324-kh2aal5n 205 26 SARS SARS NNP cord-325324-kh2aal5n 205 27 Coronavirus Coronavirus NNP cord-325324-kh2aal5n 205 28 Structure Structure NNP cord-325324-kh2aal5n 205 29 , , , cord-325324-kh2aal5n 205 30 Function Function NNP cord-325324-kh2aal5n 205 31 , , , cord-325324-kh2aal5n 205 32 and and CC cord-325324-kh2aal5n 205 33 Antigenicity Antigenicity NNP cord-325324-kh2aal5n 205 34 of of IN cord-325324-kh2aal5n 205 35 the the DT cord-325324-kh2aal5n 205 36 SARS SARS NNP cord-325324-kh2aal5n 205 37 - - HYPH cord-325324-kh2aal5n 205 38 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 205 39 Spike Spike NNP cord-325324-kh2aal5n 205 40 Glycoprotein Glycoprotein NNP cord-325324-kh2aal5n 205 41 SARS SARS NNP cord-325324-kh2aal5n 205 42 - - HYPH cord-325324-kh2aal5n 205 43 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 205 44 Cell Cell NNP cord-325324-kh2aal5n 205 45 Entry entry NN cord-325324-kh2aal5n 205 46 Depends depend VBZ cord-325324-kh2aal5n 205 47 on on IN cord-325324-kh2aal5n 205 48 ACE2 ACE2 NNP cord-325324-kh2aal5n 205 49 and and CC cord-325324-kh2aal5n 205 50 TMPRSS2 TMPRSS2 NNP cord-325324-kh2aal5n 205 51 and and CC cord-325324-kh2aal5n 206 1 Is be VBZ cord-325324-kh2aal5n 206 2 Blocked block VBN cord-325324-kh2aal5n 206 3 by by IN cord-325324-kh2aal5n 206 4 a a DT cord-325324-kh2aal5n 206 5 Clinically clinically RB cord-325324-kh2aal5n 206 6 Proven prove VBN cord-325324-kh2aal5n 206 7 Protease protease NN cord-325324-kh2aal5n 206 8 Inhibitor Inhibitor NNP cord-325324-kh2aal5n 206 9 Structural Structural NNP cord-325324-kh2aal5n 206 10 and and CC cord-325324-kh2aal5n 206 11 Functional Functional NNP cord-325324-kh2aal5n 206 12 Basis Basis NNP cord-325324-kh2aal5n 206 13 of of IN cord-325324-kh2aal5n 206 14 SARS SARS NNP cord-325324-kh2aal5n 206 15 - - HYPH cord-325324-kh2aal5n 206 16 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 206 17 Entry Entry NNP cord-325324-kh2aal5n 206 18 by by IN cord-325324-kh2aal5n 206 19 Using use VBG cord-325324-kh2aal5n 206 20 Human Human NNP cord-325324-kh2aal5n 206 21 ACE2 ACE2 NNP cord-325324-kh2aal5n 206 22 Structural structural JJ cord-325324-kh2aal5n 206 23 basis basis NN cord-325324-kh2aal5n 206 24 for for IN cord-325324-kh2aal5n 206 25 the the DT cord-325324-kh2aal5n 206 26 recognition recognition NN cord-325324-kh2aal5n 206 27 of of IN cord-325324-kh2aal5n 206 28 SARS SARS NNP cord-325324-kh2aal5n 206 29 - - HYPH cord-325324-kh2aal5n 206 30 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 206 31 by by IN cord-325324-kh2aal5n 206 32 full full JJ cord-325324-kh2aal5n 206 33 - - HYPH cord-325324-kh2aal5n 206 34 length length NN cord-325324-kh2aal5n 206 35 human human JJ cord-325324-kh2aal5n 206 36 ACE2 ace2 NN cord-325324-kh2aal5n 207 1 The the DT cord-325324-kh2aal5n 207 2 impact impact NN cord-325324-kh2aal5n 207 3 of of IN cord-325324-kh2aal5n 207 4 mutations mutation NNS cord-325324-kh2aal5n 207 5 in in IN cord-325324-kh2aal5n 207 6 SARS SARS NNP cord-325324-kh2aal5n 207 7 - - HYPH cord-325324-kh2aal5n 207 8 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 207 9 spike spike NN cord-325324-kh2aal5n 207 10 on on IN cord-325324-kh2aal5n 207 11 viral viral JJ cord-325324-kh2aal5n 207 12 infectivity infectivity NN cord-325324-kh2aal5n 207 13 and and CC cord-325324-kh2aal5n 207 14 antigenicity antigenicity NN cord-325324-kh2aal5n 207 15 Enhanced enhanced JJ cord-325324-kh2aal5n 207 16 receptor receptor NN cord-325324-kh2aal5n 207 17 binding binding NN cord-325324-kh2aal5n 207 18 of of IN cord-325324-kh2aal5n 207 19 SARS SARS NNP cord-325324-kh2aal5n 207 20 - - HYPH cord-325324-kh2aal5n 207 21 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 207 22 through through IN cord-325324-kh2aal5n 207 23 networks network NNS cord-325324-kh2aal5n 207 24 of of IN cord-325324-kh2aal5n 207 25 hydrogen hydrogen NN cord-325324-kh2aal5n 207 26 - - HYPH cord-325324-kh2aal5n 207 27 bonding bonding NN cord-325324-kh2aal5n 207 28 and and CC cord-325324-kh2aal5n 207 29 hydrophobic hydrophobic JJ cord-325324-kh2aal5n 207 30 interactions interaction NNS cord-325324-kh2aal5n 208 1 Key key JJ cord-325324-kh2aal5n 208 2 residues residue NNS cord-325324-kh2aal5n 208 3 of of IN cord-325324-kh2aal5n 208 4 the the DT cord-325324-kh2aal5n 208 5 receptor receptor NN cord-325324-kh2aal5n 208 6 binding bind VBG cord-325324-kh2aal5n 208 7 motif motif NN cord-325324-kh2aal5n 208 8 in in IN cord-325324-kh2aal5n 208 9 the the DT cord-325324-kh2aal5n 208 10 spike spike NN cord-325324-kh2aal5n 208 11 protein protein NN cord-325324-kh2aal5n 208 12 of of IN cord-325324-kh2aal5n 208 13 SARS SARS NNP cord-325324-kh2aal5n 208 14 - - : cord-325324-kh2aal5n 208 15 CoV-2 CoV-2 NNP cord-325324-kh2aal5n 208 16 that that WDT cord-325324-kh2aal5n 208 17 interact interact VBP cord-325324-kh2aal5n 208 18 with with IN cord-325324-kh2aal5n 208 19 ACE2 ACE2 NNP cord-325324-kh2aal5n 208 20 and and CC cord-325324-kh2aal5n 209 1 neutralizing neutralize VBG cord-325324-kh2aal5n 209 2 antibodies antibodies NNPS cord-325324-kh2aal5n 209 3 Association Association NNP cord-325324-kh2aal5n 209 4 of of IN cord-325324-kh2aal5n 209 5 ACE2 ACE2 NNP cord-325324-kh2aal5n 209 6 genetic genetic JJ cord-325324-kh2aal5n 209 7 polymorphisms polymorphism NNS cord-325324-kh2aal5n 209 8 with with IN cord-325324-kh2aal5n 209 9 hypertension hypertension NN cord-325324-kh2aal5n 209 10 - - HYPH cord-325324-kh2aal5n 209 11 related relate VBN cord-325324-kh2aal5n 209 12 target target NN cord-325324-kh2aal5n 209 13 organ organ NN cord-325324-kh2aal5n 209 14 damages damage NNS cord-325324-kh2aal5n 209 15 in in IN cord-325324-kh2aal5n 209 16 south south JJ cord-325324-kh2aal5n 209 17 Xinjiang Xinjiang NNP cord-325324-kh2aal5n 209 18 ACE2 ACE2 NNP cord-325324-kh2aal5n 209 19 gene gene NN cord-325324-kh2aal5n 209 20 polymorphism polymorphism NN cord-325324-kh2aal5n 209 21 and and CC cord-325324-kh2aal5n 209 22 essential essential JJ cord-325324-kh2aal5n 209 23 hypertension hypertension NN cord-325324-kh2aal5n 209 24 : : : cord-325324-kh2aal5n 210 1 an an DT cord-325324-kh2aal5n 210 2 updated update VBN cord-325324-kh2aal5n 210 3 meta meta NNP cord-325324-kh2aal5n 210 4 - - HYPH cord-325324-kh2aal5n 210 5 analysis analysis NN cord-325324-kh2aal5n 210 6 involving involve VBG cord-325324-kh2aal5n 210 7 11,051 11,051 CD cord-325324-kh2aal5n 210 8 subjects subject NNS cord-325324-kh2aal5n 210 9 Updated update VBN cord-325324-kh2aal5n 210 10 understanding understanding NN cord-325324-kh2aal5n 210 11 of of IN cord-325324-kh2aal5n 210 12 the the DT cord-325324-kh2aal5n 210 13 outbreak outbreak NN cord-325324-kh2aal5n 210 14 of of IN cord-325324-kh2aal5n 210 15 2019 2019 CD cord-325324-kh2aal5n 210 16 novel novel JJ cord-325324-kh2aal5n 210 17 coronavirus coronavirus NN cord-325324-kh2aal5n 210 18 ( ( -LRB- cord-325324-kh2aal5n 210 19 2019-nCoV 2019-ncov CD cord-325324-kh2aal5n 210 20 ) ) -RRB- cord-325324-kh2aal5n 210 21 in in IN cord-325324-kh2aal5n 210 22 Wuhan Wuhan NNP cord-325324-kh2aal5n 210 23 Covid-19 Covid-19 NNP cord-325324-kh2aal5n 210 24 : : : cord-325324-kh2aal5n 210 25 death death NN cord-325324-kh2aal5n 210 26 rate rate NN cord-325324-kh2aal5n 210 27 is be VBZ cord-325324-kh2aal5n 210 28 0.66 0.66 CD cord-325324-kh2aal5n 210 29 % % NN cord-325324-kh2aal5n 210 30 and and CC cord-325324-kh2aal5n 210 31 increases increase NNS cord-325324-kh2aal5n 210 32 with with IN cord-325324-kh2aal5n 210 33 age age NN cord-325324-kh2aal5n 210 34 , , , cord-325324-kh2aal5n 210 35 study study NN cord-325324-kh2aal5n 210 36 estimates estimate VBZ cord-325324-kh2aal5n 210 37 Estimates estimate NNS cord-325324-kh2aal5n 210 38 of of IN cord-325324-kh2aal5n 210 39 the the DT cord-325324-kh2aal5n 210 40 severity severity NN cord-325324-kh2aal5n 210 41 of of IN cord-325324-kh2aal5n 210 42 coronavirus coronavirus NN cord-325324-kh2aal5n 210 43 disease disease NN cord-325324-kh2aal5n 210 44 2019 2019 CD cord-325324-kh2aal5n 210 45 : : : cord-325324-kh2aal5n 210 46 a a DT cord-325324-kh2aal5n 210 47 model model NN cord-325324-kh2aal5n 210 48 - - HYPH cord-325324-kh2aal5n 210 49 based base VBN cord-325324-kh2aal5n 210 50 analysis analysis NN cord-325324-kh2aal5n 210 51 Protecting protect VBG cord-325324-kh2aal5n 210 52 older old JJR cord-325324-kh2aal5n 210 53 people people NNS cord-325324-kh2aal5n 210 54 from from IN cord-325324-kh2aal5n 210 55 COVID-19 covid-19 NN cord-325324-kh2aal5n 210 56 : : : cord-325324-kh2aal5n 210 57 should should MD cord-325324-kh2aal5n 210 58 the the DT cord-325324-kh2aal5n 210 59 United United NNP cord-325324-kh2aal5n 210 60 Kingdom Kingdom NNP cord-325324-kh2aal5n 210 61 start start VB cord-325324-kh2aal5n 210 62 at at IN cord-325324-kh2aal5n 210 63 age age NN cord-325324-kh2aal5n 210 64 60 60 CD cord-325324-kh2aal5n 210 65 ? ? . cord-325324-kh2aal5n 211 1 Estimating estimate VBG cord-325324-kh2aal5n 211 2 the the DT cord-325324-kh2aal5n 211 3 infection infection NN cord-325324-kh2aal5n 211 4 and and CC cord-325324-kh2aal5n 211 5 case case NN cord-325324-kh2aal5n 211 6 fatality fatality NN cord-325324-kh2aal5n 211 7 ratio ratio NN cord-325324-kh2aal5n 211 8 for for IN cord-325324-kh2aal5n 211 9 coronavirus coronavirus NN cord-325324-kh2aal5n 211 10 disease disease NN cord-325324-kh2aal5n 211 11 ( ( -LRB- cord-325324-kh2aal5n 211 12 COVID-19 covid-19 VB cord-325324-kh2aal5n 211 13 ) ) -RRB- cord-325324-kh2aal5n 211 14 using use VBG cord-325324-kh2aal5n 211 15 ageadjusted ageadjuste VBN cord-325324-kh2aal5n 211 16 data datum NNS cord-325324-kh2aal5n 211 17 from from IN cord-325324-kh2aal5n 211 18 the the DT cord-325324-kh2aal5n 211 19 outbreak outbreak NN cord-325324-kh2aal5n 211 20 on on IN cord-325324-kh2aal5n 211 21 the the DT cord-325324-kh2aal5n 211 22 Diamond Diamond NNP cord-325324-kh2aal5n 211 23 Princess Princess NNP cord-325324-kh2aal5n 211 24 cruise cruise NN cord-325324-kh2aal5n 211 25 ship ship NN cord-325324-kh2aal5n 211 26 Biomarkers Biomarkers NNPS cord-325324-kh2aal5n 211 27 of of IN cord-325324-kh2aal5n 211 28 biological biological JJ cord-325324-kh2aal5n 211 29 age age NN cord-325324-kh2aal5n 211 30 as as IN cord-325324-kh2aal5n 211 31 predictors predictor NNS cord-325324-kh2aal5n 211 32 of of IN cord-325324-kh2aal5n 211 33 COVID-19 covid-19 JJ cord-325324-kh2aal5n 211 34 disease disease NN cord-325324-kh2aal5n 211 35 severity severity NN cord-325324-kh2aal5n 211 36 Human Human NNP cord-325324-kh2aal5n 211 37 aminopeptidase aminopeptidase NN cord-325324-kh2aal5n 211 38 N N NNP cord-325324-kh2aal5n 211 39 is be VBZ cord-325324-kh2aal5n 211 40 a a DT cord-325324-kh2aal5n 211 41 receptor receptor NN cord-325324-kh2aal5n 211 42 for for IN cord-325324-kh2aal5n 211 43 human human JJ cord-325324-kh2aal5n 211 44 coronavirus coronavirus NN cord-325324-kh2aal5n 211 45 229E 229e CD cord-325324-kh2aal5n 211 46 Structural structural JJ cord-325324-kh2aal5n 211 47 and and CC cord-325324-kh2aal5n 211 48 functional functional JJ cord-325324-kh2aal5n 211 49 analysis analysis NN cord-325324-kh2aal5n 211 50 of of IN cord-325324-kh2aal5n 211 51 the the DT cord-325324-kh2aal5n 211 52 surface surface NN cord-325324-kh2aal5n 211 53 protein protein NN cord-325324-kh2aal5n 211 54 of of IN cord-325324-kh2aal5n 211 55 human human JJ cord-325324-kh2aal5n 211 56 coronavirus coronavirus NN cord-325324-kh2aal5n 211 57 OC43 OC43 NNP cord-325324-kh2aal5n 211 58 Receptor Receptor NNP cord-325324-kh2aal5n 211 59 and and CC cord-325324-kh2aal5n 211 60 viral viral JJ cord-325324-kh2aal5n 211 61 determinants determinant NNS cord-325324-kh2aal5n 211 62 of of IN cord-325324-kh2aal5n 211 63 SARS SARS NNP cord-325324-kh2aal5n 211 64 - - HYPH cord-325324-kh2aal5n 211 65 coronavirus coronavirus NN cord-325324-kh2aal5n 211 66 adaptation adaptation NN cord-325324-kh2aal5n 211 67 to to IN cord-325324-kh2aal5n 211 68 human human JJ cord-325324-kh2aal5n 211 69 ACE2 ACE2 NNP cord-325324-kh2aal5n 211 70 Receptor Receptor NNP cord-325324-kh2aal5n 211 71 usage usage NN cord-325324-kh2aal5n 211 72 and and CC cord-325324-kh2aal5n 211 73 cell cell NN cord-325324-kh2aal5n 211 74 entry entry NN cord-325324-kh2aal5n 211 75 of of IN cord-325324-kh2aal5n 211 76 bat bat NN cord-325324-kh2aal5n 211 77 coronavirus coronavirus NN cord-325324-kh2aal5n 211 78 HKU4 HKU4 NNPS cord-325324-kh2aal5n 211 79 provide provide VBP cord-325324-kh2aal5n 211 80 insight insight NN cord-325324-kh2aal5n 211 81 into into IN cord-325324-kh2aal5n 211 82 bat bat NN cord-325324-kh2aal5n 211 83 - - HYPH cord-325324-kh2aal5n 211 84 to to IN cord-325324-kh2aal5n 211 85 - - HYPH cord-325324-kh2aal5n 211 86 human human JJ cord-325324-kh2aal5n 211 87 transmission transmission NN cord-325324-kh2aal5n 211 88 of of IN cord-325324-kh2aal5n 211 89 MERS MERS NNP cord-325324-kh2aal5n 211 90 coronavirus coronavirus NN cord-325324-kh2aal5n 211 91 Dipeptidyl Dipeptidyl NNP cord-325324-kh2aal5n 211 92 peptidase peptidase NN cord-325324-kh2aal5n 211 93 4 4 CD cord-325324-kh2aal5n 211 94 is be VBZ cord-325324-kh2aal5n 211 95 a a DT cord-325324-kh2aal5n 211 96 functional functional JJ cord-325324-kh2aal5n 211 97 receptor receptor NN cord-325324-kh2aal5n 211 98 for for IN cord-325324-kh2aal5n 211 99 the the DT cord-325324-kh2aal5n 211 100 emerging emerge VBG cord-325324-kh2aal5n 211 101 human human JJ cord-325324-kh2aal5n 211 102 coronavirus coronavirus NN cord-325324-kh2aal5n 211 103 - - HYPH cord-325324-kh2aal5n 211 104 EMC EMC NNP