id sid tid token lemma pos cord-324859-0yuhb5dl 1 1 key key JJ cord-324859-0yuhb5dl 1 2 : : : cord-324859-0yuhb5dl 1 3 cord-324859 cord-324859 NNP cord-324859-0yuhb5dl 1 4 - - HYPH cord-324859-0yuhb5dl 1 5 0yuhb5dl 0yuhb5dl JJ cord-324859-0yuhb5dl 1 6 authors author NNS cord-324859-0yuhb5dl 1 7 : : : cord-324859-0yuhb5dl 1 8 Mulchandani Mulchandani NNP cord-324859-0yuhb5dl 1 9 , , , cord-324859-0yuhb5dl 1 10 Rubina Rubina NNP cord-324859-0yuhb5dl 1 11 ; ; : cord-324859-0yuhb5dl 1 12 Lyngdoh Lyngdoh NNP cord-324859-0yuhb5dl 1 13 , , , cord-324859-0yuhb5dl 1 14 Tanica Tanica NNP cord-324859-0yuhb5dl 1 15 ; ; : cord-324859-0yuhb5dl 1 16 Kakkar Kakkar NNP cord-324859-0yuhb5dl 1 17 , , , cord-324859-0yuhb5dl 1 18 Ashish Ashish NNP cord-324859-0yuhb5dl 1 19 Kumar Kumar NNP cord-324859-0yuhb5dl 1 20 title title NN cord-324859-0yuhb5dl 1 21 : : : cord-324859-0yuhb5dl 1 22 Deciphering decipher VBG cord-324859-0yuhb5dl 1 23 the the DT cord-324859-0yuhb5dl 1 24 COVID‐19 COVID‐19 NNP cord-324859-0yuhb5dl 1 25 cytokine cytokine NN cord-324859-0yuhb5dl 1 26 storm storm NN cord-324859-0yuhb5dl 1 27 : : : cord-324859-0yuhb5dl 1 28 Systematic systematic JJ cord-324859-0yuhb5dl 1 29 review review NN cord-324859-0yuhb5dl 1 30 and and CC cord-324859-0yuhb5dl 1 31 meta‐analysis meta‐analysis NN cord-324859-0yuhb5dl 1 32 date date NN cord-324859-0yuhb5dl 1 33 : : : cord-324859-0yuhb5dl 1 34 2020 2020 CD cord-324859-0yuhb5dl 1 35 - - HYPH cord-324859-0yuhb5dl 1 36 11 11 CD cord-324859-0yuhb5dl 1 37 - - HYPH cord-324859-0yuhb5dl 1 38 02 02 CD cord-324859-0yuhb5dl 1 39 journal journal NN cord-324859-0yuhb5dl 1 40 : : : cord-324859-0yuhb5dl 2 1 Eur Eur NNP cord-324859-0yuhb5dl 2 2 J J NNP cord-324859-0yuhb5dl 2 3 Clin Clin NNP cord-324859-0yuhb5dl 2 4 Invest Invest NNP cord-324859-0yuhb5dl 2 5 DOI doi NN cord-324859-0yuhb5dl 2 6 : : : cord-324859-0yuhb5dl 3 1 10.1111 10.1111 CD cord-324859-0yuhb5dl 3 2 / / SYM cord-324859-0yuhb5dl 3 3 eci.13429 eci.13429 NNP cord-324859-0yuhb5dl 3 4 sha sha NNP cord-324859-0yuhb5dl 3 5 : : : cord-324859-0yuhb5dl 4 1 3d1371dbad38cd36a1054f60a87360bb8e8eba46 3d1371dbad38cd36a1054f60a87360bb8e8eba46 CD cord-324859-0yuhb5dl 4 2 doc_id doc_id CD cord-324859-0yuhb5dl 4 3 : : : cord-324859-0yuhb5dl 4 4 324859 324859 CD cord-324859-0yuhb5dl 4 5 cord_uid cord_uid NNS cord-324859-0yuhb5dl 4 6 : : : cord-324859-0yuhb5dl 5 1 0yuhb5dl 0yuhb5dl CD cord-324859-0yuhb5dl 5 2 INTRODUCTION INTRODUCTION NNP cord-324859-0yuhb5dl 5 3 : : : cord-324859-0yuhb5dl 6 1 The the DT cord-324859-0yuhb5dl 6 2 coronavirus coronavirus NN cord-324859-0yuhb5dl 6 3 pandemic pandemic NN cord-324859-0yuhb5dl 6 4 has have VBZ cord-324859-0yuhb5dl 6 5 affected affect VBN cord-324859-0yuhb5dl 6 6 more more JJR cord-324859-0yuhb5dl 6 7 than than IN cord-324859-0yuhb5dl 6 8 20 20 CD cord-324859-0yuhb5dl 6 9 million million CD cord-324859-0yuhb5dl 6 10 people people NNS cord-324859-0yuhb5dl 6 11 so so RB cord-324859-0yuhb5dl 6 12 far far RB cord-324859-0yuhb5dl 6 13 . . . cord-324859-0yuhb5dl 7 1 Elevated elevated JJ cord-324859-0yuhb5dl 7 2 cytokines cytokine NNS cord-324859-0yuhb5dl 7 3 and and CC cord-324859-0yuhb5dl 7 4 suppressed suppress VBD cord-324859-0yuhb5dl 7 5 immune immune JJ cord-324859-0yuhb5dl 7 6 responses response NNS cord-324859-0yuhb5dl 7 7 have have VBP cord-324859-0yuhb5dl 7 8 been be VBN cord-324859-0yuhb5dl 7 9 hypothesized hypothesize VBN cord-324859-0yuhb5dl 7 10 to to TO cord-324859-0yuhb5dl 7 11 set set VB cord-324859-0yuhb5dl 7 12 off off RP cord-324859-0yuhb5dl 7 13 a a DT cord-324859-0yuhb5dl 7 14 cytokine cytokine NN cord-324859-0yuhb5dl 7 15 storm storm NN cord-324859-0yuhb5dl 7 16 , , , cord-324859-0yuhb5dl 7 17 contributing contribute VBG cord-324859-0yuhb5dl 7 18 to to IN cord-324859-0yuhb5dl 7 19 ARDS ARDS NNP cord-324859-0yuhb5dl 7 20 , , , cord-324859-0yuhb5dl 7 21 multiple‐organ multiple‐organ JJ cord-324859-0yuhb5dl 7 22 failure failure NN cord-324859-0yuhb5dl 7 23 and and CC cord-324859-0yuhb5dl 7 24 , , , cord-324859-0yuhb5dl 7 25 in in IN cord-324859-0yuhb5dl 7 26 the the DT cord-324859-0yuhb5dl 7 27 most most RBS cord-324859-0yuhb5dl 7 28 severe severe JJ cord-324859-0yuhb5dl 7 29 cases case NNS cord-324859-0yuhb5dl 7 30 , , , cord-324859-0yuhb5dl 7 31 death death NN cord-324859-0yuhb5dl 7 32 . . . cord-324859-0yuhb5dl 8 1 We -PRON- PRP cord-324859-0yuhb5dl 8 2 aimed aim VBD cord-324859-0yuhb5dl 8 3 to to TO cord-324859-0yuhb5dl 8 4 quantify quantify VB cord-324859-0yuhb5dl 8 5 the the DT cord-324859-0yuhb5dl 8 6 differences difference NNS cord-324859-0yuhb5dl 8 7 in in IN cord-324859-0yuhb5dl 8 8 the the DT cord-324859-0yuhb5dl 8 9 circulating circulate VBG cord-324859-0yuhb5dl 8 10 levels level NNS cord-324859-0yuhb5dl 8 11 of of IN cord-324859-0yuhb5dl 8 12 major major JJ cord-324859-0yuhb5dl 8 13 inflammatory inflammatory JJ cord-324859-0yuhb5dl 8 14 and and CC cord-324859-0yuhb5dl 8 15 immunological immunological JJ cord-324859-0yuhb5dl 8 16 markers marker NNS cord-324859-0yuhb5dl 8 17 between between IN cord-324859-0yuhb5dl 8 18 severe severe JJ cord-324859-0yuhb5dl 8 19 and and CC cord-324859-0yuhb5dl 8 20 nonsevere nonsevere JJ cord-324859-0yuhb5dl 8 21 COVID‐19 covid‐19 NN cord-324859-0yuhb5dl 8 22 patients patient NNS cord-324859-0yuhb5dl 8 23 . . . cord-324859-0yuhb5dl 9 1 METHODS methods NN cord-324859-0yuhb5dl 9 2 : : : cord-324859-0yuhb5dl 10 1 Relevant relevant JJ cord-324859-0yuhb5dl 10 2 studies study NNS cord-324859-0yuhb5dl 10 3 were be VBD cord-324859-0yuhb5dl 10 4 identified identify VBN cord-324859-0yuhb5dl 10 5 from from IN cord-324859-0yuhb5dl 10 6 PubMed PubMed NNP cord-324859-0yuhb5dl 10 7 , , , cord-324859-0yuhb5dl 10 8 EMBASE EMBASE NNP cord-324859-0yuhb5dl 10 9 , , , cord-324859-0yuhb5dl 10 10 Web web NN cord-324859-0yuhb5dl 10 11 of of IN cord-324859-0yuhb5dl 10 12 Science Science NNP cord-324859-0yuhb5dl 10 13 , , , cord-324859-0yuhb5dl 10 14 SCOPUS SCOPUS NNP cord-324859-0yuhb5dl 10 15 and and CC cord-324859-0yuhb5dl 10 16 preprint preprint NN cord-324859-0yuhb5dl 10 17 servers server NNS cord-324859-0yuhb5dl 10 18 . . . cord-324859-0yuhb5dl 11 1 Risk risk NN cord-324859-0yuhb5dl 11 2 of of IN cord-324859-0yuhb5dl 11 3 bias bias NN cord-324859-0yuhb5dl 11 4 was be VBD cord-324859-0yuhb5dl 11 5 assessed assess VBN cord-324859-0yuhb5dl 11 6 for for IN cord-324859-0yuhb5dl 11 7 each each DT cord-324859-0yuhb5dl 11 8 study study NN cord-324859-0yuhb5dl 11 9 , , , cord-324859-0yuhb5dl 11 10 using use VBG cord-324859-0yuhb5dl 11 11 appropriate appropriate JJ cord-324859-0yuhb5dl 11 12 checklists checklist NNS cord-324859-0yuhb5dl 11 13 . . . cord-324859-0yuhb5dl 12 1 All all DT cord-324859-0yuhb5dl 12 2 studies study NNS cord-324859-0yuhb5dl 12 3 were be VBD cord-324859-0yuhb5dl 12 4 described describe VBN cord-324859-0yuhb5dl 12 5 qualitatively qualitatively RB cord-324859-0yuhb5dl 12 6 and and CC cord-324859-0yuhb5dl 12 7 a a DT cord-324859-0yuhb5dl 12 8 subset subset NN cord-324859-0yuhb5dl 12 9 was be VBD cord-324859-0yuhb5dl 12 10 included include VBN cord-324859-0yuhb5dl 12 11 in in IN cord-324859-0yuhb5dl 12 12 the the DT cord-324859-0yuhb5dl 12 13 meta‐analysis meta‐analysis NNP cord-324859-0yuhb5dl 12 14 , , , cord-324859-0yuhb5dl 12 15 using use VBG cord-324859-0yuhb5dl 12 16 forest forest NN cord-324859-0yuhb5dl 12 17 plots plot NNS cord-324859-0yuhb5dl 12 18 . . . cord-324859-0yuhb5dl 13 1 RESULTS result NNS cord-324859-0yuhb5dl 13 2 : : : cord-324859-0yuhb5dl 14 1 Based base VBN cord-324859-0yuhb5dl 14 2 on on IN cord-324859-0yuhb5dl 14 3 23 23 CD cord-324859-0yuhb5dl 14 4 studies study NNS cord-324859-0yuhb5dl 14 5 , , , cord-324859-0yuhb5dl 14 6 mean mean VB cord-324859-0yuhb5dl 14 7 cytokine cytokine NN cord-324859-0yuhb5dl 14 8 levels level NNS cord-324859-0yuhb5dl 14 9 were be VBD cord-324859-0yuhb5dl 14 10 significantly significantly RB cord-324859-0yuhb5dl 14 11 higher high JJR cord-324859-0yuhb5dl 14 12 ( ( -LRB- cord-324859-0yuhb5dl 14 13 IL‐6 il‐6 NN cord-324859-0yuhb5dl 14 14 : : : cord-324859-0yuhb5dl 14 15 MD MD NNP cord-324859-0yuhb5dl 14 16 , , , cord-324859-0yuhb5dl 14 17 19.55 19.55 CD cord-324859-0yuhb5dl 14 18 pg pg NN cord-324859-0yuhb5dl 14 19 / / SYM cord-324859-0yuhb5dl 14 20 mL mL NNP cord-324859-0yuhb5dl 14 21 ; ; : cord-324859-0yuhb5dl 14 22 CI CI NNP cord-324859-0yuhb5dl 14 23 , , , cord-324859-0yuhb5dl 14 24 14.80 14.80 CD cord-324859-0yuhb5dl 14 25 , , , cord-324859-0yuhb5dl 14 26 24.30 24.30 CD cord-324859-0yuhb5dl 14 27 ; ; : cord-324859-0yuhb5dl 14 28 IL‐8 IL‐8 NNP cord-324859-0yuhb5dl 14 29 : : : cord-324859-0yuhb5dl 14 30 MD MD NNP cord-324859-0yuhb5dl 14 31 , , , cord-324859-0yuhb5dl 14 32 19.18 19.18 CD cord-324859-0yuhb5dl 14 33 pg pg NN cord-324859-0yuhb5dl 14 34 / / SYM cord-324859-0yuhb5dl 14 35 mL mL NNP cord-324859-0yuhb5dl 14 36 ; ; : cord-324859-0yuhb5dl 14 37 CI CI NNP cord-324859-0yuhb5dl 14 38 , , , cord-324859-0yuhb5dl 14 39 2.94 2.94 CD cord-324859-0yuhb5dl 14 40 , , , cord-324859-0yuhb5dl 14 41 35.43 35.43 CD cord-324859-0yuhb5dl 14 42 ; ; : cord-324859-0yuhb5dl 15 1 IL‐10 IL‐10 NNP cord-324859-0yuhb5dl 15 2 : : : cord-324859-0yuhb5dl 15 3 MD MD NNP cord-324859-0yuhb5dl 15 4 , , , cord-324859-0yuhb5dl 15 5 3.66 3.66 CD cord-324859-0yuhb5dl 15 6 pg pg NN cord-324859-0yuhb5dl 15 7 / / SYM cord-324859-0yuhb5dl 15 8 mL ml NN cord-324859-0yuhb5dl 15 9 ; ; : cord-324859-0yuhb5dl 15 10 CI CI NNP cord-324859-0yuhb5dl 15 11 , , , cord-324859-0yuhb5dl 15 12 2.41 2.41 CD cord-324859-0yuhb5dl 15 13 , , , cord-324859-0yuhb5dl 15 14 4.92 4.92 CD cord-324859-0yuhb5dl 15 15 ; ; : cord-324859-0yuhb5dl 15 16 IL‐2R il‐2r NN cord-324859-0yuhb5dl 15 17 : : : cord-324859-0yuhb5dl 15 18 MD MD NNP cord-324859-0yuhb5dl 15 19 , , , cord-324859-0yuhb5dl 15 20 521.36 521.36 CD cord-324859-0yuhb5dl 15 21 U u NN cord-324859-0yuhb5dl 15 22 / / SYM cord-324859-0yuhb5dl 15 23 mL ml NN cord-324859-0yuhb5dl 15 24 ; ; : cord-324859-0yuhb5dl 15 25 CI CI NNP cord-324859-0yuhb5dl 15 26 , , , cord-324859-0yuhb5dl 15 27 87.15 87.15 CD cord-324859-0yuhb5dl 15 28 , , , cord-324859-0yuhb5dl 15 29 955.57 955.57 CD cord-324859-0yuhb5dl 15 30 ; ; : cord-324859-0yuhb5dl 15 31 and and CC cord-324859-0yuhb5dl 16 1 TNF‐alpha tnf‐alpha NN cord-324859-0yuhb5dl 16 2 : : : cord-324859-0yuhb5dl 16 3 MD MD NNP cord-324859-0yuhb5dl 16 4 , , , cord-324859-0yuhb5dl 16 5 1.11 1.11 CD cord-324859-0yuhb5dl 16 6 pg pg NN cord-324859-0yuhb5dl 16 7 / / SYM cord-324859-0yuhb5dl 16 8 mL ml NN cord-324859-0yuhb5dl 16 9 ; ; : cord-324859-0yuhb5dl 16 10 CI CI NNP cord-324859-0yuhb5dl 16 11 , , , cord-324859-0yuhb5dl 16 12 0.07 0.07 CD cord-324859-0yuhb5dl 16 13 , , , cord-324859-0yuhb5dl 16 14 2.15 2.15 CD cord-324859-0yuhb5dl 16 15 ) ) -RRB- cord-324859-0yuhb5dl 16 16 and and CC cord-324859-0yuhb5dl 16 17 T‐lymphocyte T‐lymphocyte NNP cord-324859-0yuhb5dl 16 18 levels level NNS cord-324859-0yuhb5dl 16 19 were be VBD cord-324859-0yuhb5dl 16 20 significantly significantly RB cord-324859-0yuhb5dl 16 21 lower low JJR cord-324859-0yuhb5dl 16 22 ( ( -LRB- cord-324859-0yuhb5dl 16 23 CD4 CD4 NNP cord-324859-0yuhb5dl 16 24 + + CC cord-324859-0yuhb5dl 16 25 T T NNP cord-324859-0yuhb5dl 16 26 cells cell NNS cord-324859-0yuhb5dl 16 27 : : : cord-324859-0yuhb5dl 16 28 MD MD NNP cord-324859-0yuhb5dl 16 29 , , , cord-324859-0yuhb5dl 16 30 −165.28 −165.28 NNP cord-324859-0yuhb5dl 16 31 cells/µL cells/µL NNP cord-324859-0yuhb5dl 16 32 ; ; : cord-324859-0yuhb5dl 16 33 CI CI NNP cord-324859-0yuhb5dl 16 34 , , , cord-324859-0yuhb5dl 16 35 −207.58 −207.58 NNP cord-324859-0yuhb5dl 16 36 , , , cord-324859-0yuhb5dl 16 37 −122.97 −122.97 NNP cord-324859-0yuhb5dl 16 38 ; ; : cord-324859-0yuhb5dl 16 39 CD8 CD8 NNP cord-324859-0yuhb5dl 16 40 + + CC cord-324859-0yuhb5dl 16 41 T T NNP cord-324859-0yuhb5dl 16 42 cells cell NNS cord-324859-0yuhb5dl 16 43 : : : cord-324859-0yuhb5dl 16 44 MD MD NNP cord-324859-0yuhb5dl 16 45 , , , cord-324859-0yuhb5dl 16 46 −106.51 −106.51 NNP cord-324859-0yuhb5dl 16 47 cells/µL cells/µL NNP cord-324859-0yuhb5dl 16 48 ; ; : cord-324859-0yuhb5dl 16 49 CI CI NNP cord-324859-0yuhb5dl 16 50 , , , cord-324859-0yuhb5dl 16 51 −128.59 −128.59 NNP cord-324859-0yuhb5dl 16 52 , , , cord-324859-0yuhb5dl 16 53 −84.43 −84.43 XX cord-324859-0yuhb5dl 16 54 ) ) -RRB- cord-324859-0yuhb5dl 16 55 among among IN cord-324859-0yuhb5dl 16 56 severe severe JJ cord-324859-0yuhb5dl 16 57 cases case NNS cord-324859-0yuhb5dl 16 58 as as IN cord-324859-0yuhb5dl 16 59 compared compare VBN cord-324859-0yuhb5dl 16 60 to to IN cord-324859-0yuhb5dl 16 61 nonsevere nonsevere JJ cord-324859-0yuhb5dl 16 62 ones one NNS cord-324859-0yuhb5dl 16 63 . . . cord-324859-0yuhb5dl 17 1 There there EX cord-324859-0yuhb5dl 17 2 was be VBD cord-324859-0yuhb5dl 17 3 heterogeneity heterogeneity NN cord-324859-0yuhb5dl 17 4 across across IN cord-324859-0yuhb5dl 17 5 studies study NNS cord-324859-0yuhb5dl 17 6 due due JJ cord-324859-0yuhb5dl 17 7 to to IN cord-324859-0yuhb5dl 17 8 small small JJ cord-324859-0yuhb5dl 17 9 sample sample NN cord-324859-0yuhb5dl 17 10 sizes size NNS cord-324859-0yuhb5dl 17 11 and and CC cord-324859-0yuhb5dl 17 12 nonuniformity nonuniformity NN cord-324859-0yuhb5dl 17 13 in in IN cord-324859-0yuhb5dl 17 14 outcome outcome NN cord-324859-0yuhb5dl 17 15 assessment assessment NN cord-324859-0yuhb5dl 17 16 and and CC cord-324859-0yuhb5dl 17 17 varied varied JJ cord-324859-0yuhb5dl 17 18 definitions definition NNS cord-324859-0yuhb5dl 17 19 of of IN cord-324859-0yuhb5dl 17 20 disease disease NN cord-324859-0yuhb5dl 17 21 severity severity NN cord-324859-0yuhb5dl 17 22 . . . cord-324859-0yuhb5dl 18 1 The the DT cord-324859-0yuhb5dl 18 2 overall overall JJ cord-324859-0yuhb5dl 18 3 quality quality NN cord-324859-0yuhb5dl 18 4 of of IN cord-324859-0yuhb5dl 18 5 studies study NNS cord-324859-0yuhb5dl 18 6 was be VBD cord-324859-0yuhb5dl 18 7 sub‐optimal sub‐optimal VBN cord-324859-0yuhb5dl 18 8 . . . cord-324859-0yuhb5dl 19 1 CONCLUSION conclusion NN cord-324859-0yuhb5dl 19 2 : : : cord-324859-0yuhb5dl 20 1 Severe severe JJ cord-324859-0yuhb5dl 20 2 COVID‐19 covid‐19 NN cord-324859-0yuhb5dl 20 3 is be VBZ cord-324859-0yuhb5dl 20 4 characterized characterize VBN cord-324859-0yuhb5dl 20 5 by by IN cord-324859-0yuhb5dl 20 6 significantly significantly RB cord-324859-0yuhb5dl 20 7 increased increase VBN cord-324859-0yuhb5dl 20 8 levels level NNS cord-324859-0yuhb5dl 20 9 of of IN cord-324859-0yuhb5dl 20 10 pro‐inflammatory pro‐inflammatory NN cord-324859-0yuhb5dl 20 11 cytokines cytokine NNS cord-324859-0yuhb5dl 20 12 and and CC cord-324859-0yuhb5dl 20 13 reduced reduce VBN cord-324859-0yuhb5dl 20 14 T t NN cord-324859-0yuhb5dl 20 15 lymphocytes lymphocyte NNS cord-324859-0yuhb5dl 20 16 . . . cord-324859-0yuhb5dl 21 1 Well‐designed well‐designe VBN cord-324859-0yuhb5dl 21 2 and and CC cord-324859-0yuhb5dl 21 3 adequately adequately RB cord-324859-0yuhb5dl 21 4 powered power VBD cord-324859-0yuhb5dl 21 5 prospective prospective JJ cord-324859-0yuhb5dl 21 6 studies study NNS cord-324859-0yuhb5dl 21 7 are be VBP cord-324859-0yuhb5dl 21 8 needed need VBN cord-324859-0yuhb5dl 21 9 to to TO cord-324859-0yuhb5dl 21 10 amplify amplify VB cord-324859-0yuhb5dl 21 11 the the DT cord-324859-0yuhb5dl 21 12 current current JJ cord-324859-0yuhb5dl 21 13 evidence evidence NN cord-324859-0yuhb5dl 21 14 and and CC cord-324859-0yuhb5dl 21 15 provide provide VB cord-324859-0yuhb5dl 21 16 definitive definitive JJ cord-324859-0yuhb5dl 21 17 answers answer NNS cord-324859-0yuhb5dl 21 18 to to IN cord-324859-0yuhb5dl 21 19 dilemmas dilemma NNS cord-324859-0yuhb5dl 21 20 regarding regard VBG cord-324859-0yuhb5dl 21 21 timing timing NN cord-324859-0yuhb5dl 21 22 and and CC cord-324859-0yuhb5dl 21 23 type type NN cord-324859-0yuhb5dl 21 24 of of IN cord-324859-0yuhb5dl 21 25 anti‐COVID‐19 anti‐covid‐19 CD cord-324859-0yuhb5dl 21 26 therapy therapy NN cord-324859-0yuhb5dl 21 27 particularly particularly RB cord-324859-0yuhb5dl 21 28 in in IN cord-324859-0yuhb5dl 21 29 severe severe JJ cord-324859-0yuhb5dl 21 30 patients patient NNS cord-324859-0yuhb5dl 21 31 . . . cord-324859-0yuhb5dl 22 1 In in IN cord-324859-0yuhb5dl 22 2 December December NNP cord-324859-0yuhb5dl 22 3 of of IN cord-324859-0yuhb5dl 22 4 2019 2019 CD cord-324859-0yuhb5dl 22 5 , , , cord-324859-0yuhb5dl 22 6 an an DT cord-324859-0yuhb5dl 22 7 outbreak outbreak NN cord-324859-0yuhb5dl 22 8 of of IN cord-324859-0yuhb5dl 22 9 a a DT cord-324859-0yuhb5dl 22 10 novel novel JJ cord-324859-0yuhb5dl 22 11 strain strain NN cord-324859-0yuhb5dl 22 12 of of IN cord-324859-0yuhb5dl 22 13 coronavirus coronavirus NN cord-324859-0yuhb5dl 22 14 named name VBN cord-324859-0yuhb5dl 22 15 as as IN cord-324859-0yuhb5dl 22 16 severe severe JJ cord-324859-0yuhb5dl 22 17 acute acute JJ cord-324859-0yuhb5dl 22 18 respiratory respiratory JJ cord-324859-0yuhb5dl 22 19 syndrome syndrome NN cord-324859-0yuhb5dl 22 20 coronavirus-2 coronavirus-2 NNP cord-324859-0yuhb5dl 22 21 ( ( -LRB- cord-324859-0yuhb5dl 22 22 SARS SARS NNP cord-324859-0yuhb5dl 22 23 - - HYPH cord-324859-0yuhb5dl 22 24 CoV-2 CoV-2 NNP cord-324859-0yuhb5dl 22 25 ) ) -RRB- cord-324859-0yuhb5dl 22 26 originated originate VBD cord-324859-0yuhb5dl 22 27 in in IN cord-324859-0yuhb5dl 22 28 Wuhan Wuhan NNP cord-324859-0yuhb5dl 22 29 , , , cord-324859-0yuhb5dl 22 30 China China NNP cord-324859-0yuhb5dl 22 31 , , , cord-324859-0yuhb5dl 22 32 and and CC cord-324859-0yuhb5dl 22 33 rapidly rapidly RB cord-324859-0yuhb5dl 22 34 spread spread VBD cord-324859-0yuhb5dl 22 35 across across IN cord-324859-0yuhb5dl 22 36 the the DT cord-324859-0yuhb5dl 22 37 globe globe NN cord-324859-0yuhb5dl 22 38 . . . cord-324859-0yuhb5dl 23 1 The the DT cord-324859-0yuhb5dl 23 2 disease disease NN cord-324859-0yuhb5dl 23 3 caused cause VBN cord-324859-0yuhb5dl 23 4 by by IN cord-324859-0yuhb5dl 23 5 the the DT cord-324859-0yuhb5dl 23 6 virus virus NN cord-324859-0yuhb5dl 23 7 is be VBZ cord-324859-0yuhb5dl 23 8 officially officially RB cord-324859-0yuhb5dl 23 9 called call VBN cord-324859-0yuhb5dl 23 10 coronavirus coronavirus NN cord-324859-0yuhb5dl 23 11 disease disease NN cord-324859-0yuhb5dl 23 12 19 19 CD cord-324859-0yuhb5dl 23 13 . . . cord-324859-0yuhb5dl 24 1 The the DT cord-324859-0yuhb5dl 24 2 outbreak outbreak NN cord-324859-0yuhb5dl 24 3 was be VBD cord-324859-0yuhb5dl 24 4 declared declare VBN cord-324859-0yuhb5dl 24 5 a a DT cord-324859-0yuhb5dl 24 6 Public Public NNP cord-324859-0yuhb5dl 24 7 Health Health NNP cord-324859-0yuhb5dl 24 8 Emergency Emergency NNP cord-324859-0yuhb5dl 24 9 of of IN cord-324859-0yuhb5dl 24 10 International International NNP cord-324859-0yuhb5dl 24 11 Concern Concern NNP cord-324859-0yuhb5dl 24 12 and and CC cord-324859-0yuhb5dl 24 13 a a DT cord-324859-0yuhb5dl 24 14 pandemic pandemic NN cord-324859-0yuhb5dl 24 15 by by IN cord-324859-0yuhb5dl 24 16 the the DT cord-324859-0yuhb5dl 24 17 World World NNP cord-324859-0yuhb5dl 24 18 Health Health NNP cord-324859-0yuhb5dl 24 19 Organization Organization NNP cord-324859-0yuhb5dl 24 20 ( ( -LRB- cord-324859-0yuhb5dl 24 21 WHO who WP cord-324859-0yuhb5dl 24 22 ) ) -RRB- cord-324859-0yuhb5dl 24 23 in in IN cord-324859-0yuhb5dl 24 24 January January NNP cord-324859-0yuhb5dl 24 25 2020 2020 CD cord-324859-0yuhb5dl 24 26 and and CC cord-324859-0yuhb5dl 24 27 March March NNP cord-324859-0yuhb5dl 24 28 2020 2020 CD cord-324859-0yuhb5dl 24 29 , , , cord-324859-0yuhb5dl 24 30 respectively respectively RB cord-324859-0yuhb5dl 24 31 . . . cord-324859-0yuhb5dl 25 1 As as IN cord-324859-0yuhb5dl 25 2 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 25 3 is be VBZ cord-324859-0yuhb5dl 25 4 raging rage VBG cord-324859-0yuhb5dl 25 5 around around IN cord-324859-0yuhb5dl 25 6 the the DT cord-324859-0yuhb5dl 25 7 globe globe NN cord-324859-0yuhb5dl 25 8 having have VBG cord-324859-0yuhb5dl 25 9 affected affect VBN cord-324859-0yuhb5dl 25 10 over over IN cord-324859-0yuhb5dl 25 11 20 20 CD cord-324859-0yuhb5dl 25 12 million million CD cord-324859-0yuhb5dl 25 13 people people NNS cord-324859-0yuhb5dl 25 14 across across IN cord-324859-0yuhb5dl 25 15 more more JJR cord-324859-0yuhb5dl 25 16 than than IN cord-324859-0yuhb5dl 25 17 200 200 CD cord-324859-0yuhb5dl 25 18 countries country NNS cord-324859-0yuhb5dl 25 19 and and CC cord-324859-0yuhb5dl 25 20 causing cause VBG cord-324859-0yuhb5dl 25 21 more more JJR cord-324859-0yuhb5dl 25 22 than than IN cord-324859-0yuhb5dl 25 23 700 700 CD cord-324859-0yuhb5dl 25 24 000 000 CD cord-324859-0yuhb5dl 25 25 deaths death NNS cord-324859-0yuhb5dl 25 26 , , , cord-324859-0yuhb5dl 25 27 1 1 CD cord-324859-0yuhb5dl 25 28 deciphering decipher VBG cord-324859-0yuhb5dl 25 29 the the DT cord-324859-0yuhb5dl 25 30 unique unique JJ cord-324859-0yuhb5dl 25 31 infection infection NN cord-324859-0yuhb5dl 25 32 mode mode NN cord-324859-0yuhb5dl 25 33 of of IN cord-324859-0yuhb5dl 25 34 this this DT cord-324859-0yuhb5dl 25 35 novel novel JJ cord-324859-0yuhb5dl 25 36 virus virus NN cord-324859-0yuhb5dl 25 37 and and CC cord-324859-0yuhb5dl 25 38 its -PRON- PRP$ cord-324859-0yuhb5dl 25 39 pathophysiology pathophysiology NN cord-324859-0yuhb5dl 25 40 is be VBZ cord-324859-0yuhb5dl 25 41 a a DT cord-324859-0yuhb5dl 25 42 crucial crucial JJ cord-324859-0yuhb5dl 25 43 step step NN cord-324859-0yuhb5dl 25 44 towards towards IN cord-324859-0yuhb5dl 25 45 arresting arrest VBG cord-324859-0yuhb5dl 25 46 the the DT cord-324859-0yuhb5dl 25 47 pandemic pandemic NN cord-324859-0yuhb5dl 25 48 . . . cord-324859-0yuhb5dl 26 1 The the DT cord-324859-0yuhb5dl 26 2 current current JJ cord-324859-0yuhb5dl 26 3 pandemic pandemic NN cord-324859-0yuhb5dl 26 4 is be VBZ cord-324859-0yuhb5dl 26 5 distinctive distinctive JJ cord-324859-0yuhb5dl 26 6 in in IN cord-324859-0yuhb5dl 26 7 that that IN cord-324859-0yuhb5dl 26 8 the the DT cord-324859-0yuhb5dl 26 9 range range NN cord-324859-0yuhb5dl 26 10 of of IN cord-324859-0yuhb5dl 26 11 innate innate JJ cord-324859-0yuhb5dl 26 12 immune immune JJ cord-324859-0yuhb5dl 26 13 responses response NNS cord-324859-0yuhb5dl 26 14 is be VBZ cord-324859-0yuhb5dl 26 15 unpredictable unpredictable JJ cord-324859-0yuhb5dl 26 16 and and CC cord-324859-0yuhb5dl 26 17 varies vary VBZ cord-324859-0yuhb5dl 26 18 ; ; : cord-324859-0yuhb5dl 26 19 it -PRON- PRP cord-324859-0yuhb5dl 26 20 is be VBZ cord-324859-0yuhb5dl 26 21 strong strong JJ cord-324859-0yuhb5dl 26 22 enough enough RB cord-324859-0yuhb5dl 26 23 to to TO cord-324859-0yuhb5dl 26 24 kill kill VB cord-324859-0yuhb5dl 26 25 in in RP cord-324859-0yuhb5dl 26 26 some some DT cord-324859-0yuhb5dl 26 27 , , , cord-324859-0yuhb5dl 26 28 but but CC cord-324859-0yuhb5dl 26 29 others other NNS cord-324859-0yuhb5dl 26 30 escape escape VBP cord-324859-0yuhb5dl 26 31 with with IN cord-324859-0yuhb5dl 26 32 a a DT cord-324859-0yuhb5dl 26 33 relatively relatively RB cord-324859-0yuhb5dl 26 34 mild mild JJ cord-324859-0yuhb5dl 26 35 infection infection NN cord-324859-0yuhb5dl 26 36 . . . cord-324859-0yuhb5dl 27 1 Infections infection NNS cord-324859-0yuhb5dl 27 2 with with IN cord-324859-0yuhb5dl 27 3 other other JJ cord-324859-0yuhb5dl 27 4 subfamilies subfamily NNS cord-324859-0yuhb5dl 27 5 of of IN cord-324859-0yuhb5dl 27 6 the the DT cord-324859-0yuhb5dl 27 7 coronavirus coronavirus NN cord-324859-0yuhb5dl 27 8 are be VBP cord-324859-0yuhb5dl 27 9 generally generally RB cord-324859-0yuhb5dl 27 10 associated associate VBN cord-324859-0yuhb5dl 27 11 with with IN cord-324859-0yuhb5dl 27 12 upper upper JJ cord-324859-0yuhb5dl 27 13 respiratory respiratory JJ cord-324859-0yuhb5dl 27 14 tract tract NN cord-324859-0yuhb5dl 27 15 infections infection NNS cord-324859-0yuhb5dl 27 16 ( ( -LRB- cord-324859-0yuhb5dl 27 17 RTIs rti NNS cord-324859-0yuhb5dl 27 18 ) ) -RRB- cord-324859-0yuhb5dl 27 19 although although IN cord-324859-0yuhb5dl 27 20 some some DT cord-324859-0yuhb5dl 27 21 patients patient NNS cord-324859-0yuhb5dl 27 22 may may MD cord-324859-0yuhb5dl 27 23 present present VB cord-324859-0yuhb5dl 27 24 with with IN cord-324859-0yuhb5dl 27 25 lower low JJR cord-324859-0yuhb5dl 27 26 RTIs rti NNS cord-324859-0yuhb5dl 27 27 too too RB cord-324859-0yuhb5dl 27 28 . . . cord-324859-0yuhb5dl 28 1 In in IN cord-324859-0yuhb5dl 28 2 contrast contrast NN cord-324859-0yuhb5dl 28 3 , , , cord-324859-0yuhb5dl 28 4 the the DT cord-324859-0yuhb5dl 28 5 SARS SARS NNP cord-324859-0yuhb5dl 28 6 - - HYPH cord-324859-0yuhb5dl 28 7 CoV-2 CoV-2 NNP cord-324859-0yuhb5dl 28 8 infection infection NN cord-324859-0yuhb5dl 28 9 may may MD cord-324859-0yuhb5dl 28 10 remain remain VB cord-324859-0yuhb5dl 28 11 asymptomatic asymptomatic JJ cord-324859-0yuhb5dl 28 12 in in IN cord-324859-0yuhb5dl 28 13 the the DT cord-324859-0yuhb5dl 28 14 early early JJ cord-324859-0yuhb5dl 28 15 stages stage NNS cord-324859-0yuhb5dl 28 16 until until IN cord-324859-0yuhb5dl 28 17 the the DT cord-324859-0yuhb5dl 28 18 emergence emergence NN cord-324859-0yuhb5dl 28 19 of of IN cord-324859-0yuhb5dl 28 20 severe severe JJ cord-324859-0yuhb5dl 28 21 pneumonia pneumonia NN cord-324859-0yuhb5dl 28 22 , , , cord-324859-0yuhb5dl 28 23 dyspnea dyspnea NN cord-324859-0yuhb5dl 28 24 , , , cord-324859-0yuhb5dl 28 25 organ organ NN cord-324859-0yuhb5dl 28 26 dysfunction dysfunction NN cord-324859-0yuhb5dl 28 27 and and CC cord-324859-0yuhb5dl 28 28 even even RB cord-324859-0yuhb5dl 28 29 death death NN cord-324859-0yuhb5dl 28 30 . . . cord-324859-0yuhb5dl 29 1 2 2 CD cord-324859-0yuhb5dl 29 2 Pulmonary pulmonary JJ cord-324859-0yuhb5dl 29 3 lesions lesion NNS cord-324859-0yuhb5dl 29 4 in in IN cord-324859-0yuhb5dl 29 5 COVID-19 covid-19 JJ cord-324859-0yuhb5dl 29 6 show show NN cord-324859-0yuhb5dl 29 7 pathological pathological JJ cord-324859-0yuhb5dl 29 8 changes change NNS cord-324859-0yuhb5dl 29 9 , , , cord-324859-0yuhb5dl 29 10 degeneration degeneration NN cord-324859-0yuhb5dl 29 11 , , , cord-324859-0yuhb5dl 29 12 infiltration infiltration NN cord-324859-0yuhb5dl 29 13 and and CC cord-324859-0yuhb5dl 29 14 hyperplasia hyperplasia NN cord-324859-0yuhb5dl 29 15 consistent consistent JJ cord-324859-0yuhb5dl 29 16 with with IN cord-324859-0yuhb5dl 29 17 inflammatory inflammatory JJ cord-324859-0yuhb5dl 29 18 response response NN cord-324859-0yuhb5dl 29 19 throughout throughout IN cord-324859-0yuhb5dl 29 20 the the DT cord-324859-0yuhb5dl 29 21 course course NN cord-324859-0yuhb5dl 29 22 of of IN cord-324859-0yuhb5dl 29 23 the the DT cord-324859-0yuhb5dl 29 24 disease disease NN cord-324859-0yuhb5dl 29 25 . . . cord-324859-0yuhb5dl 30 1 2 2 LS cord-324859-0yuhb5dl 31 1 In in IN cord-324859-0yuhb5dl 31 2 certain certain JJ cord-324859-0yuhb5dl 31 3 cases case NNS cord-324859-0yuhb5dl 31 4 , , , cord-324859-0yuhb5dl 31 5 the the DT cord-324859-0yuhb5dl 31 6 disease disease NN cord-324859-0yuhb5dl 31 7 triggers trigger VBZ cord-324859-0yuhb5dl 31 8 a a DT cord-324859-0yuhb5dl 31 9 hyper hyper JJ cord-324859-0yuhb5dl 31 10 - - JJ cord-324859-0yuhb5dl 31 11 inflammatory inflammatory JJ cord-324859-0yuhb5dl 31 12 condition condition NN cord-324859-0yuhb5dl 31 13 3 3 CD cord-324859-0yuhb5dl 31 14 that that WDT cord-324859-0yuhb5dl 31 15 is be VBZ cord-324859-0yuhb5dl 31 16 potentially potentially RB cord-324859-0yuhb5dl 31 17 life life NN cord-324859-0yuhb5dl 31 18 - - HYPH cord-324859-0yuhb5dl 31 19 threatening threaten VBG cord-324859-0yuhb5dl 31 20 and and CC cord-324859-0yuhb5dl 31 21 is be VBZ cord-324859-0yuhb5dl 31 22 often often RB cord-324859-0yuhb5dl 31 23 responsible responsible JJ cord-324859-0yuhb5dl 31 24 for for IN cord-324859-0yuhb5dl 31 25 COVID-19 covid-19 JJ cord-324859-0yuhb5dl 31 26 fatality fatality NN cord-324859-0yuhb5dl 31 27 . . . cord-324859-0yuhb5dl 32 1 4 4 LS cord-324859-0yuhb5dl 33 1 The the DT cord-324859-0yuhb5dl 33 2 immune immune JJ cord-324859-0yuhb5dl 33 3 pathogenesis pathogenesis NN cord-324859-0yuhb5dl 33 4 associated associate VBN cord-324859-0yuhb5dl 33 5 with with IN cord-324859-0yuhb5dl 33 6 an an DT cord-324859-0yuhb5dl 33 7 aberrant aberrant JJ cord-324859-0yuhb5dl 33 8 immune immune JJ cord-324859-0yuhb5dl 33 9 response response NN cord-324859-0yuhb5dl 33 10 results result NNS cord-324859-0yuhb5dl 33 11 in in IN cord-324859-0yuhb5dl 33 12 lung lung NN cord-324859-0yuhb5dl 33 13 damage damage NN cord-324859-0yuhb5dl 33 14 , , , cord-324859-0yuhb5dl 33 15 functional functional JJ cord-324859-0yuhb5dl 33 16 impairment impairment NN cord-324859-0yuhb5dl 33 17 , , , cord-324859-0yuhb5dl 33 18 reduced reduce VBN cord-324859-0yuhb5dl 33 19 pulmonary pulmonary JJ cord-324859-0yuhb5dl 33 20 capacity capacity NN cord-324859-0yuhb5dl 33 21 and and CC cord-324859-0yuhb5dl 33 22 eventually eventually RB cord-324859-0yuhb5dl 33 23 death death NN cord-324859-0yuhb5dl 33 24 . . . cord-324859-0yuhb5dl 34 1 2 2 LS cord-324859-0yuhb5dl 35 1 Such such JJ cord-324859-0yuhb5dl 35 2 ' ' `` cord-324859-0yuhb5dl 35 3 cytokine cytokine NN cord-324859-0yuhb5dl 35 4 storm storm NN cord-324859-0yuhb5dl 35 5 ' ' '' cord-324859-0yuhb5dl 35 6 syndromes syndrome NNS cord-324859-0yuhb5dl 35 7 are be VBP cord-324859-0yuhb5dl 35 8 described describe VBN cord-324859-0yuhb5dl 35 9 by by IN cord-324859-0yuhb5dl 35 10 inappropriately inappropriately RB cord-324859-0yuhb5dl 35 11 elevated elevate VBN cord-324859-0yuhb5dl 35 12 pro pro JJ cord-324859-0yuhb5dl 35 13 - - JJ cord-324859-0yuhb5dl 35 14 inflammatory inflammatory JJ cord-324859-0yuhb5dl 35 15 cytokines cytokine NNS cord-324859-0yuhb5dl 35 16 and and CC cord-324859-0yuhb5dl 35 17 chemokines chemokine NNS cord-324859-0yuhb5dl 35 18 produced produce VBN cord-324859-0yuhb5dl 35 19 by by IN cord-324859-0yuhb5dl 35 20 a a DT cord-324859-0yuhb5dl 35 21 dysregulated dysregulate VBN cord-324859-0yuhb5dl 35 22 immune immune JJ cord-324859-0yuhb5dl 35 23 response response NN cord-324859-0yuhb5dl 35 24 with with IN cord-324859-0yuhb5dl 35 25 subsequent subsequent JJ cord-324859-0yuhb5dl 35 26 multi multi JJ cord-324859-0yuhb5dl 35 27 - - JJ cord-324859-0yuhb5dl 35 28 organ organ JJ cord-324859-0yuhb5dl 35 29 failure failure NN cord-324859-0yuhb5dl 35 30 . . . cord-324859-0yuhb5dl 36 1 Interestingly interestingly RB cord-324859-0yuhb5dl 36 2 , , , cord-324859-0yuhb5dl 36 3 the the DT cord-324859-0yuhb5dl 36 4 COVID-19-associated covid-19-associated JJ cord-324859-0yuhb5dl 36 5 cytokine cytokine NN cord-324859-0yuhb5dl 36 6 storm storm NN cord-324859-0yuhb5dl 36 7 is be VBZ cord-324859-0yuhb5dl 36 8 distinctive distinctive JJ cord-324859-0yuhb5dl 36 9 in in IN cord-324859-0yuhb5dl 36 10 being be VBG cord-324859-0yuhb5dl 36 11 associated associate VBN cord-324859-0yuhb5dl 36 12 with with IN cord-324859-0yuhb5dl 36 13 early early JJ cord-324859-0yuhb5dl 36 14 acute acute JJ cord-324859-0yuhb5dl 36 15 respiratory respiratory JJ cord-324859-0yuhb5dl 36 16 distress distress NN cord-324859-0yuhb5dl 36 17 syndrome syndrome NN cord-324859-0yuhb5dl 36 18 ( ( -LRB- cord-324859-0yuhb5dl 36 19 ARDS ARDS NNP cord-324859-0yuhb5dl 36 20 ) ) -RRB- cord-324859-0yuhb5dl 36 21 and and CC cord-324859-0yuhb5dl 36 22 coagulopathy coagulopathy NN cord-324859-0yuhb5dl 36 23 , , , cord-324859-0yuhb5dl 36 24 and and CC cord-324859-0yuhb5dl 36 25 biochemical biochemical JJ cord-324859-0yuhb5dl 36 26 parameters parameter NNS cord-324859-0yuhb5dl 36 27 include include VBP cord-324859-0yuhb5dl 36 28 elevated elevate VBN cord-324859-0yuhb5dl 36 29 but but CC cord-324859-0yuhb5dl 36 30 lower low JJR cord-324859-0yuhb5dl 36 31 serum serum NN cord-324859-0yuhb5dl 36 32 ferritin ferritin NNS cord-324859-0yuhb5dl 36 33 and and CC cord-324859-0yuhb5dl 36 34 lower low JJR cord-324859-0yuhb5dl 36 35 interleukin-6 interleukin-6 NNP cord-324859-0yuhb5dl 36 36 levels level NNS cord-324859-0yuhb5dl 36 37 as as IN cord-324859-0yuhb5dl 36 38 compared compare VBN cord-324859-0yuhb5dl 36 39 to to IN cord-324859-0yuhb5dl 36 40 those those DT cord-324859-0yuhb5dl 36 41 encountered encounter VBN cord-324859-0yuhb5dl 36 42 in in IN cord-324859-0yuhb5dl 36 43 other other JJ cord-324859-0yuhb5dl 36 44 cytokine cytokine NN cord-324859-0yuhb5dl 36 45 storm storm NN cord-324859-0yuhb5dl 36 46 syndromes syndrome NNS cord-324859-0yuhb5dl 36 47 . . . cord-324859-0yuhb5dl 37 1 5 5 CD cord-324859-0yuhb5dl 37 2 , , , cord-324859-0yuhb5dl 37 3 6 6 CD cord-324859-0yuhb5dl 38 1 Given give VBN cord-324859-0yuhb5dl 38 2 the the DT cord-324859-0yuhb5dl 38 3 novelty novelty NN cord-324859-0yuhb5dl 38 4 of of IN cord-324859-0yuhb5dl 38 5 the the DT cord-324859-0yuhb5dl 38 6 disease disease NN cord-324859-0yuhb5dl 38 7 , , , cord-324859-0yuhb5dl 38 8 definitive definitive JJ cord-324859-0yuhb5dl 38 9 insights insight NNS cord-324859-0yuhb5dl 38 10 into into IN cord-324859-0yuhb5dl 38 11 the the DT cord-324859-0yuhb5dl 38 12 dynamics dynamic NNS cord-324859-0yuhb5dl 38 13 of of IN cord-324859-0yuhb5dl 38 14 the the DT cord-324859-0yuhb5dl 38 15 dysfunctional dysfunctional JJ cord-324859-0yuhb5dl 38 16 inflammatory inflammatory JJ cord-324859-0yuhb5dl 38 17 reaction reaction NN cord-324859-0yuhb5dl 38 18 in in IN cord-324859-0yuhb5dl 38 19 the the DT cord-324859-0yuhb5dl 38 20 context context NN cord-324859-0yuhb5dl 38 21 of of IN cord-324859-0yuhb5dl 38 22 cellular cellular JJ cord-324859-0yuhb5dl 38 23 immune immune JJ cord-324859-0yuhb5dl 38 24 responses response NNS cord-324859-0yuhb5dl 38 25 in in IN cord-324859-0yuhb5dl 38 26 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 38 27 are be VBP cord-324859-0yuhb5dl 38 28 much much RB cord-324859-0yuhb5dl 38 29 awaited await VBN cord-324859-0yuhb5dl 38 30 and and CC cord-324859-0yuhb5dl 38 31 anticipated anticipate VBN cord-324859-0yuhb5dl 38 32 . . . cord-324859-0yuhb5dl 39 1 Understanding understand VBG cord-324859-0yuhb5dl 39 2 the the DT cord-324859-0yuhb5dl 39 3 biological biological JJ cord-324859-0yuhb5dl 39 4 and and CC cord-324859-0yuhb5dl 39 5 clinical clinical JJ cord-324859-0yuhb5dl 39 6 consequences consequence NNS cord-324859-0yuhb5dl 39 7 of of IN cord-324859-0yuhb5dl 39 8 the the DT cord-324859-0yuhb5dl 39 9 role role NN cord-324859-0yuhb5dl 39 10 of of IN cord-324859-0yuhb5dl 39 11 pro pro JJ cord-324859-0yuhb5dl 39 12 - - JJ cord-324859-0yuhb5dl 39 13 inflammatory inflammatory JJ cord-324859-0yuhb5dl 39 14 cytokines cytokine NNS cord-324859-0yuhb5dl 39 15 in in IN cord-324859-0yuhb5dl 39 16 the the DT cord-324859-0yuhb5dl 39 17 pathogenesis pathogenesis NN cord-324859-0yuhb5dl 39 18 of of IN cord-324859-0yuhb5dl 39 19 the the DT cord-324859-0yuhb5dl 39 20 disease disease NN cord-324859-0yuhb5dl 39 21 is be VBZ cord-324859-0yuhb5dl 39 22 important important JJ cord-324859-0yuhb5dl 39 23 for for IN cord-324859-0yuhb5dl 39 24 the the DT cord-324859-0yuhb5dl 39 25 scientific scientific JJ cord-324859-0yuhb5dl 39 26 community community NN cord-324859-0yuhb5dl 39 27 as as IN cord-324859-0yuhb5dl 39 28 they -PRON- PRP cord-324859-0yuhb5dl 39 29 are be VBP cord-324859-0yuhb5dl 39 30 racing race VBG cord-324859-0yuhb5dl 39 31 against against IN cord-324859-0yuhb5dl 39 32 time time NN cord-324859-0yuhb5dl 39 33 to to TO cord-324859-0yuhb5dl 39 34 develop develop VB cord-324859-0yuhb5dl 39 35 therapeutics therapeutic NNS cord-324859-0yuhb5dl 39 36 to to TO cord-324859-0yuhb5dl 39 37 treat treat VB cord-324859-0yuhb5dl 39 38 patients patient NNS cord-324859-0yuhb5dl 39 39 . . . cord-324859-0yuhb5dl 40 1 There there EX cord-324859-0yuhb5dl 40 2 has have VBZ cord-324859-0yuhb5dl 40 3 been be VBN cord-324859-0yuhb5dl 40 4 some some DT cord-324859-0yuhb5dl 40 5 sporadic sporadic JJ cord-324859-0yuhb5dl 40 6 evidence evidence NN cord-324859-0yuhb5dl 40 7 to to TO cord-324859-0yuhb5dl 40 8 suggest suggest VB cord-324859-0yuhb5dl 40 9 that that IN cord-324859-0yuhb5dl 40 10 the the DT cord-324859-0yuhb5dl 40 11 level level NN cord-324859-0yuhb5dl 40 12 of of IN cord-324859-0yuhb5dl 40 13 immune immune JJ cord-324859-0yuhb5dl 40 14 response response NN cord-324859-0yuhb5dl 40 15 hyperactivity hyperactivity NN cord-324859-0yuhb5dl 40 16 is be VBZ cord-324859-0yuhb5dl 40 17 significantly significantly RB cord-324859-0yuhb5dl 40 18 higher high JJR cord-324859-0yuhb5dl 40 19 in in IN cord-324859-0yuhb5dl 40 20 patients patient NNS cord-324859-0yuhb5dl 40 21 with with IN cord-324859-0yuhb5dl 40 22 severe severe JJ cord-324859-0yuhb5dl 40 23 disease disease NN cord-324859-0yuhb5dl 40 24 , , , cord-324859-0yuhb5dl 40 25 as as IN cord-324859-0yuhb5dl 40 26 compared compare VBN cord-324859-0yuhb5dl 40 27 to to IN cord-324859-0yuhb5dl 40 28 patients patient NNS cord-324859-0yuhb5dl 40 29 with with IN cord-324859-0yuhb5dl 40 30 a a DT cord-324859-0yuhb5dl 40 31 mild mild JJ cord-324859-0yuhb5dl 40 32 infection infection NN cord-324859-0yuhb5dl 40 33 . . . cord-324859-0yuhb5dl 41 1 [ [ -LRB- cord-324859-0yuhb5dl 41 2 7 7 CD cord-324859-0yuhb5dl 41 3 ] ] -RRB- cord-324859-0yuhb5dl 41 4 [ [ -LRB- cord-324859-0yuhb5dl 41 5 8 8 CD cord-324859-0yuhb5dl 41 6 ] ] -RRB- cord-324859-0yuhb5dl 41 7 [ [ -LRB- cord-324859-0yuhb5dl 41 8 9 9 CD cord-324859-0yuhb5dl 41 9 ] ] -RRB- cord-324859-0yuhb5dl 42 1 However however RB cord-324859-0yuhb5dl 42 2 , , , cord-324859-0yuhb5dl 42 3 it -PRON- PRP cord-324859-0yuhb5dl 42 4 is be VBZ cord-324859-0yuhb5dl 42 5 crucial crucial JJ cord-324859-0yuhb5dl 42 6 to to TO cord-324859-0yuhb5dl 42 7 generate generate VB cord-324859-0yuhb5dl 42 8 systematic systematic JJ cord-324859-0yuhb5dl 42 9 evidence evidence NN cord-324859-0yuhb5dl 42 10 from from IN cord-324859-0yuhb5dl 42 11 research research NN cord-324859-0yuhb5dl 42 12 that that WDT cord-324859-0yuhb5dl 42 13 is be VBZ cord-324859-0yuhb5dl 42 14 adequately adequately RB cord-324859-0yuhb5dl 42 15 powered power VBN cord-324859-0yuhb5dl 42 16 , , , cord-324859-0yuhb5dl 42 17 to to TO cord-324859-0yuhb5dl 42 18 statistically statistically RB cord-324859-0yuhb5dl 42 19 compare compare VB cord-324859-0yuhb5dl 42 20 the the DT cord-324859-0yuhb5dl 42 21 cytokine cytokine NN cord-324859-0yuhb5dl 42 22 levels level NNS cord-324859-0yuhb5dl 42 23 in in IN cord-324859-0yuhb5dl 42 24 patients patient NNS cord-324859-0yuhb5dl 42 25 at at IN cord-324859-0yuhb5dl 42 26 various various JJ cord-324859-0yuhb5dl 42 27 stages stage NNS cord-324859-0yuhb5dl 42 28 of of IN cord-324859-0yuhb5dl 42 29 the the DT cord-324859-0yuhb5dl 42 30 illness illness NN cord-324859-0yuhb5dl 42 31 . . . cord-324859-0yuhb5dl 43 1 In in IN cord-324859-0yuhb5dl 43 2 this this DT cord-324859-0yuhb5dl 43 3 context context NN cord-324859-0yuhb5dl 43 4 , , , cord-324859-0yuhb5dl 43 5 we -PRON- PRP cord-324859-0yuhb5dl 43 6 sought seek VBD cord-324859-0yuhb5dl 43 7 to to TO cord-324859-0yuhb5dl 43 8 undertake undertake VB cord-324859-0yuhb5dl 43 9 a a DT cord-324859-0yuhb5dl 43 10 systematic systematic JJ cord-324859-0yuhb5dl 43 11 review review NN cord-324859-0yuhb5dl 43 12 and and CC cord-324859-0yuhb5dl 43 13 meta meta NNP cord-324859-0yuhb5dl 43 14 - - HYPH cord-324859-0yuhb5dl 43 15 analysis analysis NN cord-324859-0yuhb5dl 43 16 of of IN cord-324859-0yuhb5dl 43 17 available available JJ cord-324859-0yuhb5dl 43 18 evidence evidence NN cord-324859-0yuhb5dl 43 19 to to TO cord-324859-0yuhb5dl 43 20 understand understand VB cord-324859-0yuhb5dl 43 21 the the DT cord-324859-0yuhb5dl 43 22 pattern pattern NN cord-324859-0yuhb5dl 43 23 of of IN cord-324859-0yuhb5dl 43 24 host host NN cord-324859-0yuhb5dl 43 25 immune immune JJ cord-324859-0yuhb5dl 43 26 response response NN cord-324859-0yuhb5dl 43 27 in in IN cord-324859-0yuhb5dl 43 28 patients patient NNS cord-324859-0yuhb5dl 43 29 diagnosed diagnose VBN cord-324859-0yuhb5dl 43 30 with with IN cord-324859-0yuhb5dl 43 31 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 43 32 and and CC cord-324859-0yuhb5dl 43 33 how how WRB cord-324859-0yuhb5dl 43 34 the the DT cord-324859-0yuhb5dl 43 35 levels level NNS cord-324859-0yuhb5dl 43 36 of of IN cord-324859-0yuhb5dl 43 37 inflammatory inflammatory JJ cord-324859-0yuhb5dl 43 38 and and CC cord-324859-0yuhb5dl 43 39 immunological immunological JJ cord-324859-0yuhb5dl 43 40 markers marker NNS cord-324859-0yuhb5dl 43 41 vary vary VBP cord-324859-0yuhb5dl 43 42 according accord VBG cord-324859-0yuhb5dl 43 43 to to IN cord-324859-0yuhb5dl 43 44 the the DT cord-324859-0yuhb5dl 43 45 severity severity NN cord-324859-0yuhb5dl 43 46 or or CC cord-324859-0yuhb5dl 43 47 stage stage NN cord-324859-0yuhb5dl 43 48 of of IN cord-324859-0yuhb5dl 43 49 the the DT cord-324859-0yuhb5dl 43 50 disease disease NN cord-324859-0yuhb5dl 43 51 . . . cord-324859-0yuhb5dl 44 1 Systematic systematic JJ cord-324859-0yuhb5dl 44 2 reviews review NNS cord-324859-0yuhb5dl 44 3 and and CC cord-324859-0yuhb5dl 44 4 meta meta NNP cord-324859-0yuhb5dl 44 5 - - HYPH cord-324859-0yuhb5dl 44 6 analyses analysis NNS cord-324859-0yuhb5dl 44 7 provide provide VBP cord-324859-0yuhb5dl 44 8 the the DT cord-324859-0yuhb5dl 44 9 highest high JJS cord-324859-0yuhb5dl 44 10 level level NN cord-324859-0yuhb5dl 44 11 of of IN cord-324859-0yuhb5dl 44 12 evidence evidence NN cord-324859-0yuhb5dl 44 13 that that WDT cord-324859-0yuhb5dl 44 14 is be VBZ cord-324859-0yuhb5dl 44 15 statistically statistically RB cord-324859-0yuhb5dl 44 16 meaningful meaningful JJ cord-324859-0yuhb5dl 44 17 and and CC cord-324859-0yuhb5dl 44 18 thus thus RB cord-324859-0yuhb5dl 44 19 considered consider VBN cord-324859-0yuhb5dl 44 20 a a DT cord-324859-0yuhb5dl 44 21 gold gold JJ cord-324859-0yuhb5dl 44 22 standard standard NN cord-324859-0yuhb5dl 44 23 . . . cord-324859-0yuhb5dl 45 1 A a DT cord-324859-0yuhb5dl 45 2 few few JJ cord-324859-0yuhb5dl 45 3 systematic systematic JJ cord-324859-0yuhb5dl 45 4 reviews review NNS cord-324859-0yuhb5dl 45 5 and and CC cord-324859-0yuhb5dl 45 6 meta meta NNP cord-324859-0yuhb5dl 45 7 - - HYPH cord-324859-0yuhb5dl 45 8 analyses analysis NNS cord-324859-0yuhb5dl 45 9 have have VBP cord-324859-0yuhb5dl 45 10 been be VBN cord-324859-0yuhb5dl 45 11 conducted conduct VBN cord-324859-0yuhb5dl 45 12 in in IN cord-324859-0yuhb5dl 45 13 the the DT cord-324859-0yuhb5dl 45 14 last last JJ cord-324859-0yuhb5dl 45 15 few few JJ cord-324859-0yuhb5dl 45 16 months month NNS cord-324859-0yuhb5dl 45 17 , , , cord-324859-0yuhb5dl 45 18 to to TO cord-324859-0yuhb5dl 45 19 understand understand VB cord-324859-0yuhb5dl 45 20 the the DT cord-324859-0yuhb5dl 45 21 relationship relationship NN cord-324859-0yuhb5dl 45 22 between between IN cord-324859-0yuhb5dl 45 23 cytokines cytokine NNS cord-324859-0yuhb5dl 45 24 and and CC cord-324859-0yuhb5dl 45 25 the the DT cord-324859-0yuhb5dl 45 26 novel novel JJ cord-324859-0yuhb5dl 45 27 coronavirus coronavirus NN cord-324859-0yuhb5dl 45 28 disease disease NN cord-324859-0yuhb5dl 45 29 2019 2019 CD cord-324859-0yuhb5dl 45 30 . . . cord-324859-0yuhb5dl 46 1 However however RB cord-324859-0yuhb5dl 46 2 , , , cord-324859-0yuhb5dl 46 3 they -PRON- PRP cord-324859-0yuhb5dl 46 4 have have VBP cord-324859-0yuhb5dl 46 5 been be VBN cord-324859-0yuhb5dl 46 6 majorly majorly RB cord-324859-0yuhb5dl 46 7 centred centre VBN cord-324859-0yuhb5dl 46 8 on on IN cord-324859-0yuhb5dl 46 9 exploring explore VBG cord-324859-0yuhb5dl 46 10 the the DT cord-324859-0yuhb5dl 46 11 correlation correlation NN cord-324859-0yuhb5dl 46 12 between between IN cord-324859-0yuhb5dl 46 13 varying vary VBG cord-324859-0yuhb5dl 46 14 levels level NNS cord-324859-0yuhb5dl 46 15 of of IN cord-324859-0yuhb5dl 46 16 interleukin-6 interleukin-6 NNP cord-324859-0yuhb5dl 46 17 ( ( -LRB- cord-324859-0yuhb5dl 46 18 IL-6 IL-6 NNP cord-324859-0yuhb5dl 46 19 ) ) -RRB- cord-324859-0yuhb5dl 46 20 and and CC cord-324859-0yuhb5dl 46 21 the the DT cord-324859-0yuhb5dl 46 22 degree degree NN cord-324859-0yuhb5dl 46 23 of of IN cord-324859-0yuhb5dl 46 24 severity severity NN cord-324859-0yuhb5dl 46 25 of of IN cord-324859-0yuhb5dl 46 26 the the DT cord-324859-0yuhb5dl 46 27 illness illness NN cord-324859-0yuhb5dl 46 28 . . . cord-324859-0yuhb5dl 47 1 [ [ -LRB- cord-324859-0yuhb5dl 47 2 10 10 CD cord-324859-0yuhb5dl 47 3 ] ] -RRB- cord-324859-0yuhb5dl 47 4 [ [ -LRB- cord-324859-0yuhb5dl 47 5 11 11 CD cord-324859-0yuhb5dl 47 6 ] ] -RRB- cord-324859-0yuhb5dl 47 7 [ [ -LRB- cord-324859-0yuhb5dl 47 8 12 12 CD cord-324859-0yuhb5dl 47 9 ] ] -RRB- cord-324859-0yuhb5dl 48 1 A a DT cord-324859-0yuhb5dl 48 2 few few JJ cord-324859-0yuhb5dl 48 3 others other NNS cord-324859-0yuhb5dl 48 4 have have VBP cord-324859-0yuhb5dl 48 5 provided provide VBN cord-324859-0yuhb5dl 48 6 a a DT cord-324859-0yuhb5dl 48 7 broader broad JJR cord-324859-0yuhb5dl 48 8 overview overview NN cord-324859-0yuhb5dl 48 9 , , , cord-324859-0yuhb5dl 48 10 albeit albeit IN cord-324859-0yuhb5dl 48 11 utilizing utilize VBG cord-324859-0yuhb5dl 48 12 data datum NNS cord-324859-0yuhb5dl 48 13 from from IN cord-324859-0yuhb5dl 48 14 a a DT cord-324859-0yuhb5dl 48 15 very very RB cord-324859-0yuhb5dl 48 16 small small JJ cord-324859-0yuhb5dl 48 17 number number NN cord-324859-0yuhb5dl 48 18 of of IN cord-324859-0yuhb5dl 48 19 studies study NNS cord-324859-0yuhb5dl 48 20 for for IN cord-324859-0yuhb5dl 48 21 each each DT cord-324859-0yuhb5dl 48 22 outcome outcome NN cord-324859-0yuhb5dl 48 23 . . . cord-324859-0yuhb5dl 49 1 13 13 CD cord-324859-0yuhb5dl 49 2 , , , cord-324859-0yuhb5dl 49 3 14 14 CD cord-324859-0yuhb5dl 49 4 Moreover moreover RB cord-324859-0yuhb5dl 49 5 , , , cord-324859-0yuhb5dl 49 6 individual individual JJ cord-324859-0yuhb5dl 49 7 studies study NNS cord-324859-0yuhb5dl 49 8 with with IN cord-324859-0yuhb5dl 49 9 inadequate inadequate JJ cord-324859-0yuhb5dl 49 10 sample sample NN cord-324859-0yuhb5dl 49 11 sizes size NNS cord-324859-0yuhb5dl 49 12 have have VBP cord-324859-0yuhb5dl 49 13 produced produce VBN cord-324859-0yuhb5dl 49 14 conflicting conflicting JJ cord-324859-0yuhb5dl 49 15 findings finding NNS cord-324859-0yuhb5dl 49 16 possibly possibly RB cord-324859-0yuhb5dl 49 17 due due JJ cord-324859-0yuhb5dl 49 18 to to IN cord-324859-0yuhb5dl 49 19 a a DT cord-324859-0yuhb5dl 49 20 lack lack NN cord-324859-0yuhb5dl 49 21 of of IN cord-324859-0yuhb5dl 49 22 statistical statistical JJ cord-324859-0yuhb5dl 49 23 power power NN cord-324859-0yuhb5dl 49 24 . . . cord-324859-0yuhb5dl 50 1 As as IN cord-324859-0yuhb5dl 50 2 we -PRON- PRP cord-324859-0yuhb5dl 50 3 grapple grapple VBP cord-324859-0yuhb5dl 50 4 with with IN cord-324859-0yuhb5dl 50 5 a a DT cord-324859-0yuhb5dl 50 6 pandemic pandemic NN cord-324859-0yuhb5dl 50 7 and and CC cord-324859-0yuhb5dl 50 8 continue continue VBP cord-324859-0yuhb5dl 50 9 to to TO cord-324859-0yuhb5dl 50 10 get get VB cord-324859-0yuhb5dl 50 11 inundated inundate VBN cord-324859-0yuhb5dl 50 12 with with IN cord-324859-0yuhb5dl 50 13 clinical clinical JJ cord-324859-0yuhb5dl 50 14 data datum NNS cord-324859-0yuhb5dl 50 15 from from IN cord-324859-0yuhb5dl 50 16 numerous numerous JJ cord-324859-0yuhb5dl 50 17 disease disease NN cord-324859-0yuhb5dl 50 18 cohorts cohort NNS cord-324859-0yuhb5dl 50 19 , , , cord-324859-0yuhb5dl 50 20 it -PRON- PRP cord-324859-0yuhb5dl 50 21 becomes become VBZ cord-324859-0yuhb5dl 50 22 imperative imperative JJ cord-324859-0yuhb5dl 50 23 to to TO cord-324859-0yuhb5dl 50 24 collate collate VB cord-324859-0yuhb5dl 50 25 existing exist VBG cord-324859-0yuhb5dl 50 26 data datum NNS cord-324859-0yuhb5dl 50 27 and and CC cord-324859-0yuhb5dl 50 28 provide provide VB cord-324859-0yuhb5dl 50 29 the the DT cord-324859-0yuhb5dl 50 30 latest late JJS cord-324859-0yuhb5dl 50 31 scientific scientific JJ cord-324859-0yuhb5dl 50 32 evidence evidence NN cord-324859-0yuhb5dl 50 33 , , , cord-324859-0yuhb5dl 50 34 which which WDT cord-324859-0yuhb5dl 50 35 could could MD cord-324859-0yuhb5dl 50 36 be be VB cord-324859-0yuhb5dl 50 37 instrumental instrumental JJ cord-324859-0yuhb5dl 50 38 in in IN cord-324859-0yuhb5dl 50 39 informing inform VBG cord-324859-0yuhb5dl 50 40 healthcare healthcare NN cord-324859-0yuhb5dl 50 41 professionals professional NNS cord-324859-0yuhb5dl 50 42 and and CC cord-324859-0yuhb5dl 50 43 devising devise VBG cord-324859-0yuhb5dl 50 44 appropriate appropriate JJ cord-324859-0yuhb5dl 50 45 treatment treatment NN cord-324859-0yuhb5dl 50 46 strategies strategy NNS cord-324859-0yuhb5dl 50 47 . . . cord-324859-0yuhb5dl 51 1 Therefore therefore RB cord-324859-0yuhb5dl 51 2 , , , cord-324859-0yuhb5dl 51 3 our -PRON- PRP$ cord-324859-0yuhb5dl 51 4 review review NN cord-324859-0yuhb5dl 51 5 was be VBD cord-324859-0yuhb5dl 51 6 aimed aim VBN cord-324859-0yuhb5dl 51 7 to to TO cord-324859-0yuhb5dl 51 8 summarize summarize VB cord-324859-0yuhb5dl 51 9 the the DT cord-324859-0yuhb5dl 51 10 relationship relationship NN cord-324859-0yuhb5dl 51 11 between between IN cord-324859-0yuhb5dl 51 12 circulating circulate VBG cord-324859-0yuhb5dl 51 13 cytokine cytokine NN cord-324859-0yuhb5dl 51 14 levels level NNS cord-324859-0yuhb5dl 51 15 and and CC cord-324859-0yuhb5dl 51 16 COVID-19 covid-19 NN cord-324859-0yuhb5dl 51 17 , , , cord-324859-0yuhb5dl 51 18 and and CC cord-324859-0yuhb5dl 51 19 more more RBR cord-324859-0yuhb5dl 51 20 specifically specifically RB cord-324859-0yuhb5dl 51 21 focusing focus VBG cord-324859-0yuhb5dl 51 22 on on IN cord-324859-0yuhb5dl 51 23 important important JJ cord-324859-0yuhb5dl 51 24 inflammatory inflammatory JJ cord-324859-0yuhb5dl 51 25 and and CC cord-324859-0yuhb5dl 51 26 immunological immunological JJ cord-324859-0yuhb5dl 51 27 markers marker NNS cord-324859-0yuhb5dl 51 28 that that WDT cord-324859-0yuhb5dl 51 29 are be VBP cord-324859-0yuhb5dl 51 30 shown show VBN cord-324859-0yuhb5dl 51 31 to to TO cord-324859-0yuhb5dl 51 32 be be VB cord-324859-0yuhb5dl 51 33 responsible responsible JJ cord-324859-0yuhb5dl 51 34 for for IN cord-324859-0yuhb5dl 51 35 an an DT cord-324859-0yuhb5dl 51 36 exaggerated exaggerated JJ cord-324859-0yuhb5dl 51 37 immune immune JJ cord-324859-0yuhb5dl 51 38 response response NN cord-324859-0yuhb5dl 51 39 that that WDT cord-324859-0yuhb5dl 51 40 triggers trigger VBZ cord-324859-0yuhb5dl 51 41 respiratory respiratory JJ cord-324859-0yuhb5dl 51 42 distress distress NN cord-324859-0yuhb5dl 51 43 , , , cord-324859-0yuhb5dl 51 44 multi multi JJ cord-324859-0yuhb5dl 51 45 - - JJ cord-324859-0yuhb5dl 51 46 organ organ JJ cord-324859-0yuhb5dl 51 47 failure failure NN cord-324859-0yuhb5dl 51 48 and and CC cord-324859-0yuhb5dl 51 49 , , , cord-324859-0yuhb5dl 51 50 in in IN cord-324859-0yuhb5dl 51 51 the the DT cord-324859-0yuhb5dl 51 52 worst bad JJS cord-324859-0yuhb5dl 51 53 cases case NNS cord-324859-0yuhb5dl 51 54 , , , cord-324859-0yuhb5dl 51 55 death death NN cord-324859-0yuhb5dl 51 56 . . . cord-324859-0yuhb5dl 52 1 We -PRON- PRP cord-324859-0yuhb5dl 52 2 undertook undertake VBD cord-324859-0yuhb5dl 52 3 a a DT cord-324859-0yuhb5dl 52 4 systematic systematic JJ cord-324859-0yuhb5dl 52 5 and and CC cord-324859-0yuhb5dl 52 6 comprehensive comprehensive JJ cord-324859-0yuhb5dl 52 7 synthesis synthesis NN cord-324859-0yuhb5dl 52 8 of of IN cord-324859-0yuhb5dl 52 9 the the DT cord-324859-0yuhb5dl 52 10 currently currently RB cord-324859-0yuhb5dl 52 11 available available JJ cord-324859-0yuhb5dl 52 12 literature literature NN cord-324859-0yuhb5dl 52 13 , , , cord-324859-0yuhb5dl 52 14 to to TO cord-324859-0yuhb5dl 52 15 obtain obtain VB cord-324859-0yuhb5dl 52 16 a a DT cord-324859-0yuhb5dl 52 17 detailed detailed JJ cord-324859-0yuhb5dl 52 18 and and CC cord-324859-0yuhb5dl 52 19 holistic holistic JJ cord-324859-0yuhb5dl 52 20 view view NN cord-324859-0yuhb5dl 52 21 of of IN cord-324859-0yuhb5dl 52 22 the the DT cord-324859-0yuhb5dl 52 23 dynamics dynamic NNS cord-324859-0yuhb5dl 52 24 between between IN cord-324859-0yuhb5dl 52 25 the the DT cord-324859-0yuhb5dl 52 26 host host NN cord-324859-0yuhb5dl 52 27 immune immune JJ cord-324859-0yuhb5dl 52 28 response response NN cord-324859-0yuhb5dl 52 29 and and CC cord-324859-0yuhb5dl 52 30 levels level NNS cord-324859-0yuhb5dl 52 31 of of IN cord-324859-0yuhb5dl 52 32 disease disease NN cord-324859-0yuhb5dl 52 33 severity severity NN cord-324859-0yuhb5dl 52 34 among among IN cord-324859-0yuhb5dl 52 35 clinically clinically RB cord-324859-0yuhb5dl 52 36 confirmed confirm VBN cord-324859-0yuhb5dl 52 37 patients patient NNS cord-324859-0yuhb5dl 52 38 of of IN cord-324859-0yuhb5dl 52 39 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 52 40 . . . cord-324859-0yuhb5dl 53 1 To to TO cord-324859-0yuhb5dl 53 2 understand understand VB cord-324859-0yuhb5dl 53 3 the the DT cord-324859-0yuhb5dl 53 4 pattern pattern NN cord-324859-0yuhb5dl 53 5 of of IN cord-324859-0yuhb5dl 53 6 host host NN cord-324859-0yuhb5dl 53 7 immune immune JJ cord-324859-0yuhb5dl 53 8 response response NN cord-324859-0yuhb5dl 53 9 and and CC cord-324859-0yuhb5dl 53 10 summarize summarize VB cord-324859-0yuhb5dl 53 11 evidence evidence NN cord-324859-0yuhb5dl 53 12 for for IN cord-324859-0yuhb5dl 53 13 the the DT cord-324859-0yuhb5dl 53 14 difference difference NN cord-324859-0yuhb5dl 53 15 in in IN cord-324859-0yuhb5dl 53 16 the the DT cord-324859-0yuhb5dl 53 17 levels level NNS cord-324859-0yuhb5dl 53 18 of of IN cord-324859-0yuhb5dl 53 19 immunological immunological JJ cord-324859-0yuhb5dl 53 20 and and CC cord-324859-0yuhb5dl 53 21 inflammatory inflammatory JJ cord-324859-0yuhb5dl 53 22 biomarkers biomarker NNS cord-324859-0yuhb5dl 53 23 associated associate VBN cord-324859-0yuhb5dl 53 24 with with IN cord-324859-0yuhb5dl 53 25 cytokine cytokine NN cord-324859-0yuhb5dl 53 26 storm storm NN cord-324859-0yuhb5dl 53 27 , , , cord-324859-0yuhb5dl 53 28 between between IN cord-324859-0yuhb5dl 53 29 COVID-19 covid-19 JJ cord-324859-0yuhb5dl 53 30 patient patient JJ cord-324859-0yuhb5dl 53 31 groups group NNS cord-324859-0yuhb5dl 53 32 of of IN cord-324859-0yuhb5dl 53 33 varying vary VBG cord-324859-0yuhb5dl 53 34 disease disease NN cord-324859-0yuhb5dl 53 35 severity severity NN cord-324859-0yuhb5dl 53 36 . . . cord-324859-0yuhb5dl 53 37 _SP cord-324859-0yuhb5dl 54 1 The the DT cord-324859-0yuhb5dl 54 2 systematic systematic JJ cord-324859-0yuhb5dl 54 3 review review NN cord-324859-0yuhb5dl 54 4 methodology methodology NN cord-324859-0yuhb5dl 54 5 has have VBZ cord-324859-0yuhb5dl 54 6 been be VBN cord-324859-0yuhb5dl 54 7 described describe VBN cord-324859-0yuhb5dl 54 8 in in IN cord-324859-0yuhb5dl 54 9 detail detail NN cord-324859-0yuhb5dl 54 10 , , , cord-324859-0yuhb5dl 54 11 in in IN cord-324859-0yuhb5dl 54 12 the the DT cord-324859-0yuhb5dl 54 13 protocol protocol NN cord-324859-0yuhb5dl 54 14 registered register VBN cord-324859-0yuhb5dl 54 15 with with IN cord-324859-0yuhb5dl 54 16 PROSPERO PROSPERO NNP cord-324859-0yuhb5dl 54 17 ( ( -LRB- cord-324859-0yuhb5dl 54 18 registration registration NN cord-324859-0yuhb5dl 54 19 number number NN cord-324859-0yuhb5dl 54 20 : : : cord-324859-0yuhb5dl 54 21 CRD42020183246 CRD42020183246 NNP cord-324859-0yuhb5dl 54 22 ) ) -RRB- cord-324859-0yuhb5dl 54 23 . . . cord-324859-0yuhb5dl 55 1 15 15 CD cord-324859-0yuhb5dl 56 1 The the DT cord-324859-0yuhb5dl 56 2 reporting reporting NN cord-324859-0yuhb5dl 56 3 of of IN cord-324859-0yuhb5dl 56 4 this this DT cord-324859-0yuhb5dl 56 5 review review NN cord-324859-0yuhb5dl 56 6 is be VBZ cord-324859-0yuhb5dl 56 7 consistent consistent JJ cord-324859-0yuhb5dl 56 8 with with IN cord-324859-0yuhb5dl 56 9 the the DT cord-324859-0yuhb5dl 56 10 Preferred Preferred NNP cord-324859-0yuhb5dl 56 11 Reporting Reporting NNP cord-324859-0yuhb5dl 56 12 of of IN cord-324859-0yuhb5dl 56 13 Items Items NNPS cord-324859-0yuhb5dl 56 14 for for IN cord-324859-0yuhb5dl 56 15 Systematic Systematic NNP cord-324859-0yuhb5dl 56 16 Reviews Reviews NNPS cord-324859-0yuhb5dl 56 17 and and CC cord-324859-0yuhb5dl 56 18 Meta Meta NNP cord-324859-0yuhb5dl 56 19 - - HYPH cord-324859-0yuhb5dl 56 20 Analyses Analyses NNP cord-324859-0yuhb5dl 56 21 ( ( -LRB- cord-324859-0yuhb5dl 56 22 PRISMA PRISMA NNP cord-324859-0yuhb5dl 56 23 ) ) -RRB- cord-324859-0yuhb5dl 56 24 guidelines guideline VBZ cord-324859-0yuhb5dl 56 25 16 16 CD cord-324859-0yuhb5dl 56 26 as as RB cord-324859-0yuhb5dl 56 27 well well RB cord-324859-0yuhb5dl 56 28 as as IN cord-324859-0yuhb5dl 56 29 the the DT cord-324859-0yuhb5dl 56 30 Meta Meta NNP cord-324859-0yuhb5dl 56 31 - - HYPH cord-324859-0yuhb5dl 56 32 Analysis Analysis NNP cord-324859-0yuhb5dl 56 33 of of IN cord-324859-0yuhb5dl 56 34 Observational Observational NNP cord-324859-0yuhb5dl 56 35 Studies Studies NNPS cord-324859-0yuhb5dl 56 36 in in IN cord-324859-0yuhb5dl 56 37 Epidemiology Epidemiology NNP cord-324859-0yuhb5dl 56 38 ( ( -LRB- cord-324859-0yuhb5dl 56 39 MOOSE MOOSE NNP cord-324859-0yuhb5dl 56 40 ) ) -RRB- cord-324859-0yuhb5dl 56 41 recommendations recommendation NNS cord-324859-0yuhb5dl 56 42 . . . cord-324859-0yuhb5dl 57 1 17 17 CD cord-324859-0yuhb5dl 57 2 _SP cord-324859-0yuhb5dl 58 1 We -PRON- PRP cord-324859-0yuhb5dl 58 2 searched search VBD cord-324859-0yuhb5dl 58 3 PubMed PubMed NNP cord-324859-0yuhb5dl 58 4 , , , cord-324859-0yuhb5dl 58 5 EMBASE EMBASE NNP cord-324859-0yuhb5dl 58 6 , , , cord-324859-0yuhb5dl 58 7 Web web NN cord-324859-0yuhb5dl 58 8 of of IN cord-324859-0yuhb5dl 58 9 Science Science NNP cord-324859-0yuhb5dl 58 10 , , , cord-324859-0yuhb5dl 58 11 SCOPUS SCOPUS NNP cord-324859-0yuhb5dl 58 12 , , , cord-324859-0yuhb5dl 58 13 Cochrane Cochrane NNP cord-324859-0yuhb5dl 58 14 Central Central NNP cord-324859-0yuhb5dl 58 15 , , , cord-324859-0yuhb5dl 58 16 clinicaltrials.gov clinicaltrials.gov NNP cord-324859-0yuhb5dl 58 17 and and CC cord-324859-0yuhb5dl 58 18 the the DT cord-324859-0yuhb5dl 58 19 preprint preprint NN cord-324859-0yuhb5dl 58 20 server server NN cord-324859-0yuhb5dl 58 21 medRxiv medRxiv NNS cord-324859-0yuhb5dl 58 22 , , , cord-324859-0yuhb5dl 58 23 to to TO cord-324859-0yuhb5dl 58 24 obtain obtain VB cord-324859-0yuhb5dl 58 25 relevant relevant JJ cord-324859-0yuhb5dl 58 26 articles article NNS cord-324859-0yuhb5dl 58 27 on on IN cord-324859-0yuhb5dl 58 28 COVID-19 covid-19 JJ cord-324859-0yuhb5dl 58 29 patient patient JJ cord-324859-0yuhb5dl 58 30 outcomes outcome NNS cord-324859-0yuhb5dl 58 31 , , , cord-324859-0yuhb5dl 58 32 published publish VBN cord-324859-0yuhb5dl 58 33 till till IN cord-324859-0yuhb5dl 58 34 April April NNP cord-324859-0yuhb5dl 58 35 2020 2020 CD cord-324859-0yuhb5dl 58 36 . . . cord-324859-0yuhb5dl 59 1 A a DT cord-324859-0yuhb5dl 59 2 sensitive sensitive JJ cord-324859-0yuhb5dl 59 3 search search NN cord-324859-0yuhb5dl 59 4 was be VBD cord-324859-0yuhb5dl 59 5 designed design VBN cord-324859-0yuhb5dl 59 6 using use VBG cord-324859-0yuhb5dl 59 7 synonyms synonyms NN cord-324859-0yuhb5dl 59 8 for for IN cord-324859-0yuhb5dl 59 9 the the DT cord-324859-0yuhb5dl 59 10 novel novel JJ cord-324859-0yuhb5dl 59 11 coronavirus coronavirus NN cord-324859-0yuhb5dl 59 12 2019 2019 CD cord-324859-0yuhb5dl 59 13 , , , cord-324859-0yuhb5dl 59 14 along along IN cord-324859-0yuhb5dl 59 15 with with IN cord-324859-0yuhb5dl 59 16 keywords keyword NNS cord-324859-0yuhb5dl 59 17 such such JJ cord-324859-0yuhb5dl 59 18 as as IN cord-324859-0yuhb5dl 59 19 ' ' `` cord-324859-0yuhb5dl 59 20 interleukins interleukin NNS cord-324859-0yuhb5dl 59 21 ' ' '' cord-324859-0yuhb5dl 59 22 , , , cord-324859-0yuhb5dl 59 23 ' ' `` cord-324859-0yuhb5dl 59 24 cytokines cytokine NNS cord-324859-0yuhb5dl 59 25 ' ' '' cord-324859-0yuhb5dl 59 26 , , , cord-324859-0yuhb5dl 59 27 ' ' '' cord-324859-0yuhb5dl 59 28 inflammation inflammation NN cord-324859-0yuhb5dl 59 29 markers marker NNS cord-324859-0yuhb5dl 59 30 ' ' '' cord-324859-0yuhb5dl 59 31 , , , cord-324859-0yuhb5dl 59 32 ' ' `` cord-324859-0yuhb5dl 59 33 IL-6 IL-6 NNP cord-324859-0yuhb5dl 59 34 ' ' '' cord-324859-0yuhb5dl 59 35 , , , cord-324859-0yuhb5dl 59 36 ' ' `` cord-324859-0yuhb5dl 59 37 immunomodulatory immunomodulatory NNP cord-324859-0yuhb5dl 59 38 ' ' '' cord-324859-0yuhb5dl 59 39 , , , cord-324859-0yuhb5dl 59 40 ' ' '' cord-324859-0yuhb5dl 59 41 clinical clinical JJ cord-324859-0yuhb5dl 59 42 features feature NNS cord-324859-0yuhb5dl 59 43 ' ' '' cord-324859-0yuhb5dl 59 44 , , , cord-324859-0yuhb5dl 59 45 ' ' `` cord-324859-0yuhb5dl 59 46 patient patient JJ cord-324859-0yuhb5dl 59 47 outcomes outcome NNS cord-324859-0yuhb5dl 59 48 ' ' '' cord-324859-0yuhb5dl 59 49 , , , cord-324859-0yuhb5dl 59 50 combined combine VBN cord-324859-0yuhb5dl 59 51 using use VBG cord-324859-0yuhb5dl 59 52 boolean boolean JJ cord-324859-0yuhb5dl 59 53 operators operator NNS cord-324859-0yuhb5dl 59 54 as as IN cord-324859-0yuhb5dl 59 55 appropriate appropriate JJ cord-324859-0yuhb5dl 59 56 . . . cord-324859-0yuhb5dl 60 1 The the DT cord-324859-0yuhb5dl 60 2 strategies strategy NNS cord-324859-0yuhb5dl 60 3 were be VBD cord-324859-0yuhb5dl 60 4 prepared prepare VBN cord-324859-0yuhb5dl 60 5 by by IN cord-324859-0yuhb5dl 60 6 one one CD cord-324859-0yuhb5dl 60 7 investigator investigator NN cord-324859-0yuhb5dl 60 8 ( ( -LRB- cord-324859-0yuhb5dl 60 9 RM RM NNP cord-324859-0yuhb5dl 60 10 ) ) -RRB- cord-324859-0yuhb5dl 60 11 and and CC cord-324859-0yuhb5dl 60 12 reviewed review VBN cord-324859-0yuhb5dl 60 13 by by IN cord-324859-0yuhb5dl 60 14 the the DT cord-324859-0yuhb5dl 60 15 other other JJ cord-324859-0yuhb5dl 60 16 two two CD cord-324859-0yuhb5dl 60 17 investigators investigator NNS cord-324859-0yuhb5dl 60 18 ( ( -LRB- cord-324859-0yuhb5dl 60 19 AK AK NNP cord-324859-0yuhb5dl 60 20 and and CC cord-324859-0yuhb5dl 60 21 TL TL NNP cord-324859-0yuhb5dl 60 22 ) ) -RRB- cord-324859-0yuhb5dl 60 23 to to TO cord-324859-0yuhb5dl 60 24 ensure ensure VB cord-324859-0yuhb5dl 60 25 comprehensiveness comprehensiveness NN cord-324859-0yuhb5dl 60 26 . . . cord-324859-0yuhb5dl 61 1 The the DT cord-324859-0yuhb5dl 61 2 complete complete JJ cord-324859-0yuhb5dl 61 3 search search NN cord-324859-0yuhb5dl 61 4 strategy strategy NN cord-324859-0yuhb5dl 61 5 prepared prepare VBN cord-324859-0yuhb5dl 61 6 for for IN cord-324859-0yuhb5dl 61 7 PubMed PubMed NNP cord-324859-0yuhb5dl 61 8 is be VBZ cord-324859-0yuhb5dl 61 9 given give VBN cord-324859-0yuhb5dl 61 10 in in IN cord-324859-0yuhb5dl 61 11 the the DT cord-324859-0yuhb5dl 61 12 File File NNP cord-324859-0yuhb5dl 61 13 S1 S1 NNP cord-324859-0yuhb5dl 61 14 . . . cord-324859-0yuhb5dl 62 1 It -PRON- PRP cord-324859-0yuhb5dl 62 2 was be VBD cord-324859-0yuhb5dl 62 3 modified modify VBN cord-324859-0yuhb5dl 62 4 for for IN cord-324859-0yuhb5dl 62 5 use use NN cord-324859-0yuhb5dl 62 6 according accord VBG cord-324859-0yuhb5dl 62 7 to to IN cord-324859-0yuhb5dl 62 8 the the DT cord-324859-0yuhb5dl 62 9 indexing indexing NN cord-324859-0yuhb5dl 62 10 style style NN cord-324859-0yuhb5dl 62 11 of of IN cord-324859-0yuhb5dl 62 12 the the DT cord-324859-0yuhb5dl 62 13 other other JJ cord-324859-0yuhb5dl 62 14 databases database NNS cord-324859-0yuhb5dl 62 15 . . . cord-324859-0yuhb5dl 63 1 The the DT cord-324859-0yuhb5dl 63 2 reference reference NN cord-324859-0yuhb5dl 63 3 list list NN cord-324859-0yuhb5dl 63 4 of of IN cord-324859-0yuhb5dl 63 5 the the DT cord-324859-0yuhb5dl 63 6 relevant relevant JJ cord-324859-0yuhb5dl 63 7 papers paper NNS cord-324859-0yuhb5dl 63 8 was be VBD cord-324859-0yuhb5dl 63 9 also also RB cord-324859-0yuhb5dl 63 10 hand hand NN cord-324859-0yuhb5dl 63 11 - - HYPH cord-324859-0yuhb5dl 63 12 searched search VBN cord-324859-0yuhb5dl 63 13 to to TO cord-324859-0yuhb5dl 63 14 obtain obtain VB cord-324859-0yuhb5dl 63 15 any any DT cord-324859-0yuhb5dl 63 16 additional additional JJ cord-324859-0yuhb5dl 63 17 articles article NNS cord-324859-0yuhb5dl 63 18 . . . cord-324859-0yuhb5dl 64 1 Articles article NNS cord-324859-0yuhb5dl 64 2 eligible eligible JJ cord-324859-0yuhb5dl 64 3 for for IN cord-324859-0yuhb5dl 64 4 inclusion inclusion NN cord-324859-0yuhb5dl 64 5 in in IN cord-324859-0yuhb5dl 64 6 our -PRON- PRP$ cord-324859-0yuhb5dl 64 7 review review NN cord-324859-0yuhb5dl 64 8 were be VBD cord-324859-0yuhb5dl 64 9 observational observational JJ cord-324859-0yuhb5dl 64 10 studies study NNS cord-324859-0yuhb5dl 64 11 ( ( -LRB- cord-324859-0yuhb5dl 64 12 retrospective retrospective JJ cord-324859-0yuhb5dl 64 13 cohorts cohort NNS cord-324859-0yuhb5dl 64 14 , , , cord-324859-0yuhb5dl 64 15 prospective prospective JJ cord-324859-0yuhb5dl 64 16 cohorts cohort NNS cord-324859-0yuhb5dl 64 17 , , , cord-324859-0yuhb5dl 64 18 case case NN cord-324859-0yuhb5dl 64 19 - - HYPH cord-324859-0yuhb5dl 64 20 control control NN cord-324859-0yuhb5dl 64 21 studies study NNS cord-324859-0yuhb5dl 64 22 , , , cord-324859-0yuhb5dl 64 23 and and CC cord-324859-0yuhb5dl 64 24 case case NN cord-324859-0yuhb5dl 64 25 series series NN cord-324859-0yuhb5dl 64 26 ) ) -RRB- cord-324859-0yuhb5dl 64 27 or or CC cord-324859-0yuhb5dl 64 28 randomized randomize VBN cord-324859-0yuhb5dl 64 29 controlled control VBN cord-324859-0yuhb5dl 64 30 trials trial NNS cord-324859-0yuhb5dl 64 31 , , , cord-324859-0yuhb5dl 64 32 characterizing characterize VBG cord-324859-0yuhb5dl 64 33 and and CC cord-324859-0yuhb5dl 64 34 comparing compare VBG cord-324859-0yuhb5dl 64 35 severe severe JJ cord-324859-0yuhb5dl 64 36 and and CC cord-324859-0yuhb5dl 64 37 nonsevere nonsevere JJ cord-324859-0yuhb5dl 64 38 groups group NNS cord-324859-0yuhb5dl 64 39 of of IN cord-324859-0yuhb5dl 64 40 COVID-19 covid-19 JJ cord-324859-0yuhb5dl 64 41 patients patient NNS cord-324859-0yuhb5dl 64 42 . . . cord-324859-0yuhb5dl 65 1 Studies study NNS cord-324859-0yuhb5dl 65 2 measuring measure VBG cord-324859-0yuhb5dl 65 3 the the DT cord-324859-0yuhb5dl 65 4 immunological immunological JJ cord-324859-0yuhb5dl 65 5 and and CC cord-324859-0yuhb5dl 65 6 inflammatory inflammatory JJ cord-324859-0yuhb5dl 65 7 indicators indicator NNS cord-324859-0yuhb5dl 65 8 of of IN cord-324859-0yuhb5dl 65 9 cytokine cytokine NN cord-324859-0yuhb5dl 65 10 storm storm NN cord-324859-0yuhb5dl 65 11 in in IN cord-324859-0yuhb5dl 65 12 adult adult NN cord-324859-0yuhb5dl 65 13 patients patient NNS cord-324859-0yuhb5dl 65 14 with with IN cord-324859-0yuhb5dl 65 15 a a DT cord-324859-0yuhb5dl 65 16 confirmed confirm VBN cord-324859-0yuhb5dl 65 17 diagnosis diagnosis NN cord-324859-0yuhb5dl 65 18 of of IN cord-324859-0yuhb5dl 65 19 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 65 20 , , , cord-324859-0yuhb5dl 65 21 and and CC cord-324859-0yuhb5dl 65 22 comparing compare VBG cord-324859-0yuhb5dl 65 23 them -PRON- PRP cord-324859-0yuhb5dl 65 24 between between IN cord-324859-0yuhb5dl 65 25 severe severe JJ cord-324859-0yuhb5dl 65 26 and and CC cord-324859-0yuhb5dl 65 27 non non JJ cord-324859-0yuhb5dl 65 28 - - JJ cord-324859-0yuhb5dl 65 29 severe severe JJ cord-324859-0yuhb5dl 65 30 ( ( -LRB- cord-324859-0yuhb5dl 65 31 mild mild JJ cord-324859-0yuhb5dl 65 32 - - HYPH cord-324859-0yuhb5dl 65 33 moderate moderate JJ cord-324859-0yuhb5dl 65 34 ) ) -RRB- cord-324859-0yuhb5dl 65 35 cases case NNS cord-324859-0yuhb5dl 65 36 , , , cord-324859-0yuhb5dl 65 37 were be VBD cord-324859-0yuhb5dl 65 38 eligible eligible JJ cord-324859-0yuhb5dl 65 39 to to TO cord-324859-0yuhb5dl 65 40 be be VB cord-324859-0yuhb5dl 65 41 included include VBN cord-324859-0yuhb5dl 65 42 in in IN cord-324859-0yuhb5dl 65 43 our -PRON- PRP$ cord-324859-0yuhb5dl 65 44 review review NN cord-324859-0yuhb5dl 65 45 . . . cord-324859-0yuhb5dl 66 1 Disease disease NN cord-324859-0yuhb5dl 66 2 assessment assessment NN cord-324859-0yuhb5dl 66 3 and and CC cord-324859-0yuhb5dl 66 4 clinical clinical JJ cord-324859-0yuhb5dl 66 5 classification classification NN cord-324859-0yuhb5dl 66 6 in in IN cord-324859-0yuhb5dl 66 7 each each DT cord-324859-0yuhb5dl 66 8 study study NN cord-324859-0yuhb5dl 66 9 were be VBD cord-324859-0yuhb5dl 66 10 based base VBN cord-324859-0yuhb5dl 66 11 on on IN cord-324859-0yuhb5dl 66 12 evaluation evaluation NN cord-324859-0yuhb5dl 66 13 of of IN cord-324859-0yuhb5dl 66 14 symptoms symptom NNS cord-324859-0yuhb5dl 66 15 by by IN cord-324859-0yuhb5dl 66 16 the the DT cord-324859-0yuhb5dl 66 17 study study NN cord-324859-0yuhb5dl 66 18 investigators investigator NNS cord-324859-0yuhb5dl 66 19 as as IN cord-324859-0yuhb5dl 66 20 per per IN cord-324859-0yuhb5dl 66 21 the the DT cord-324859-0yuhb5dl 66 22 standard standard JJ cord-324859-0yuhb5dl 66 23 protocols protocol NNS cord-324859-0yuhb5dl 66 24 for for IN cord-324859-0yuhb5dl 66 25 the the DT cord-324859-0yuhb5dl 66 26 diagnosis diagnosis NN cord-324859-0yuhb5dl 66 27 and and CC cord-324859-0yuhb5dl 66 28 clinical clinical JJ cord-324859-0yuhb5dl 66 29 management management NN cord-324859-0yuhb5dl 66 30 of of IN cord-324859-0yuhb5dl 66 31 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 66 32 . . . cord-324859-0yuhb5dl 66 33 18 18 CD cord-324859-0yuhb5dl 66 34 , , , cord-324859-0yuhb5dl 66 35 19 19 CD cord-324859-0yuhb5dl 66 36 Severe severe JJ cord-324859-0yuhb5dl 66 37 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 66 38 according accord VBG cord-324859-0yuhb5dl 66 39 to to IN cord-324859-0yuhb5dl 66 40 both both CC cord-324859-0yuhb5dl 66 41 the the DT cord-324859-0yuhb5dl 66 42 protocols protocol NNS cord-324859-0yuhb5dl 66 43 was be VBD cord-324859-0yuhb5dl 66 44 defined define VBN cord-324859-0yuhb5dl 66 45 as as IN cord-324859-0yuhb5dl 66 46 having have VBG cord-324859-0yuhb5dl 66 47 one one CD cord-324859-0yuhb5dl 66 48 of of IN cord-324859-0yuhb5dl 66 49 the the DT cord-324859-0yuhb5dl 66 50 following follow VBG cord-324859-0yuhb5dl 66 51 : : : cord-324859-0yuhb5dl 66 52 a a DT cord-324859-0yuhb5dl 66 53 respiratory respiratory JJ cord-324859-0yuhb5dl 66 54 frequency frequency NN cord-324859-0yuhb5dl 66 55 ≥30 ≥30 NNS cord-324859-0yuhb5dl 66 56 / / SYM cord-324859-0yuhb5dl 66 57 min min NN cord-324859-0yuhb5dl 66 58 ; ; : cord-324859-0yuhb5dl 66 59 oxygen oxygen NN cord-324859-0yuhb5dl 66 60 saturation saturation NN cord-324859-0yuhb5dl 66 61 ≤ ≤ NN cord-324859-0yuhb5dl 66 62 93 93 CD cord-324859-0yuhb5dl 66 63 % % NN cord-324859-0yuhb5dl 66 64 ; ; , cord-324859-0yuhb5dl 66 65 and and CC cord-324859-0yuhb5dl 66 66 oxygenation oxygenation NN cord-324859-0yuhb5dl 66 67 index index NN cord-324859-0yuhb5dl 66 68 ( ( -LRB- cord-324859-0yuhb5dl 66 69 PaO2 PaO2 NNS cord-324859-0yuhb5dl 66 70 / / SYM cord-324859-0yuhb5dl 66 71 FiO2 FiO2 NNS cord-324859-0yuhb5dl 66 72 ) ) -RRB- cord-324859-0yuhb5dl 67 1 ≤300 ≤300 NNP cord-324859-0yuhb5dl 67 2 mm mm NNP cord-324859-0yuhb5dl 67 3 Hg Hg NNP cord-324859-0yuhb5dl 67 4 . . . cord-324859-0yuhb5dl 68 1 The the DT cord-324859-0yuhb5dl 68 2 disease disease NN cord-324859-0yuhb5dl 68 3 severity severity NN cord-324859-0yuhb5dl 68 4 groups group NNS cord-324859-0yuhb5dl 68 5 created create VBN cord-324859-0yuhb5dl 68 6 in in IN cord-324859-0yuhb5dl 68 7 every every DT cord-324859-0yuhb5dl 68 8 individual individual JJ cord-324859-0yuhb5dl 68 9 study study NN cord-324859-0yuhb5dl 68 10 were be VBD cord-324859-0yuhb5dl 68 11 used use VBN cord-324859-0yuhb5dl 68 12 as as IN cord-324859-0yuhb5dl 68 13 is be VBZ cord-324859-0yuhb5dl 68 14 , , , cord-324859-0yuhb5dl 68 15 for for IN cord-324859-0yuhb5dl 68 16 our -PRON- PRP$ cord-324859-0yuhb5dl 68 17 review review NN cord-324859-0yuhb5dl 68 18 . . . cord-324859-0yuhb5dl 69 1 Additionally additionally RB cord-324859-0yuhb5dl 69 2 , , , cord-324859-0yuhb5dl 69 3 for for IN cord-324859-0yuhb5dl 69 4 studies study NNS cord-324859-0yuhb5dl 69 5 comparing compare VBG cord-324859-0yuhb5dl 69 6 outcomes outcome NNS cord-324859-0yuhb5dl 69 7 of of IN cord-324859-0yuhb5dl 69 8 patients patient NNS cord-324859-0yuhb5dl 69 9 who who WP cord-324859-0yuhb5dl 69 10 had have VBD cord-324859-0yuhb5dl 69 11 died die VBN cord-324859-0yuhb5dl 69 12 and and CC cord-324859-0yuhb5dl 69 13 those those DT cord-324859-0yuhb5dl 69 14 who who WP cord-324859-0yuhb5dl 69 15 were be VBD cord-324859-0yuhb5dl 69 16 alive alive JJ cord-324859-0yuhb5dl 69 17 , , , cord-324859-0yuhb5dl 69 18 we -PRON- PRP cord-324859-0yuhb5dl 69 19 considered consider VBD cord-324859-0yuhb5dl 69 20 dead dead JJ cord-324859-0yuhb5dl 69 21 as as IN cord-324859-0yuhb5dl 69 22 severe severe JJ cord-324859-0yuhb5dl 69 23 and and CC cord-324859-0yuhb5dl 69 24 alive alive JJ cord-324859-0yuhb5dl 69 25 as as IN cord-324859-0yuhb5dl 69 26 the the DT cord-324859-0yuhb5dl 69 27 non non JJ cord-324859-0yuhb5dl 69 28 - - JJ cord-324859-0yuhb5dl 69 29 severe severe JJ cord-324859-0yuhb5dl 69 30 category category NN cord-324859-0yuhb5dl 69 31 . . . cord-324859-0yuhb5dl 70 1 Outcomes outcome NNS cord-324859-0yuhb5dl 70 2 included include VBD cord-324859-0yuhb5dl 70 3 circulating circulate VBG cord-324859-0yuhb5dl 70 4 levels level NNS cord-324859-0yuhb5dl 70 5 of of IN cord-324859-0yuhb5dl 70 6 interleukins interleukin NNS cord-324859-0yuhb5dl 70 7 ( ( -LRB- cord-324859-0yuhb5dl 70 8 IL-6 IL-6 NNP cord-324859-0yuhb5dl 70 9 , , , cord-324859-0yuhb5dl 70 10 IL-8 IL-8 NNP cord-324859-0yuhb5dl 70 11 , , , cord-324859-0yuhb5dl 70 12 IL-10 IL-10 NNP cord-324859-0yuhb5dl 70 13 and and CC cord-324859-0yuhb5dl 70 14 others other NNS cord-324859-0yuhb5dl 70 15 depending depend VBG cord-324859-0yuhb5dl 70 16 on on IN cord-324859-0yuhb5dl 70 17 availability availability NN cord-324859-0yuhb5dl 70 18 of of IN cord-324859-0yuhb5dl 70 19 estimates estimate NNS cord-324859-0yuhb5dl 70 20 ) ) -RRB- cord-324859-0yuhb5dl 70 21 , , , cord-324859-0yuhb5dl 70 22 tumour tumour NN cord-324859-0yuhb5dl 70 23 necrosis necrosis NN cord-324859-0yuhb5dl 70 24 factor factor NN cord-324859-0yuhb5dl 70 25 - - HYPH cord-324859-0yuhb5dl 70 26 alpha alpha NN cord-324859-0yuhb5dl 70 27 and and CC cord-324859-0yuhb5dl 70 28 T t NN cord-324859-0yuhb5dl 70 29 - - HYPH cord-324859-0yuhb5dl 70 30 lymphocyte lymphocyte NN cord-324859-0yuhb5dl 70 31 counts count NNS cord-324859-0yuhb5dl 70 32 ( ( -LRB- cord-324859-0yuhb5dl 70 33 CD4 CD4 NNP cord-324859-0yuhb5dl 70 34 + + CC cord-324859-0yuhb5dl 70 35 T T NNP cord-324859-0yuhb5dl 70 36 cells cell NNS cord-324859-0yuhb5dl 70 37 and and CC cord-324859-0yuhb5dl 70 38 CD8 CD8 NNP cord-324859-0yuhb5dl 70 39 + + CC cord-324859-0yuhb5dl 70 40 T T NNP cord-324859-0yuhb5dl 70 41 cells cell NNS cord-324859-0yuhb5dl 70 42 ) ) -RRB- cord-324859-0yuhb5dl 70 43 that that WDT cord-324859-0yuhb5dl 70 44 have have VBP cord-324859-0yuhb5dl 70 45 been be VBN cord-324859-0yuhb5dl 70 46 widely widely RB cord-324859-0yuhb5dl 70 47 reported report VBN cord-324859-0yuhb5dl 70 48 in in IN cord-324859-0yuhb5dl 70 49 relation relation NN cord-324859-0yuhb5dl 70 50 to to IN cord-324859-0yuhb5dl 70 51 the the DT cord-324859-0yuhb5dl 70 52 cytokine cytokine NN cord-324859-0yuhb5dl 70 53 storm storm NN cord-324859-0yuhb5dl 70 54 in in IN cord-324859-0yuhb5dl 70 55 patients patient NNS cord-324859-0yuhb5dl 70 56 having have VBG cord-324859-0yuhb5dl 70 57 severe severe JJ cord-324859-0yuhb5dl 70 58 COVID-19 covid-19 NN cord-324859-0yuhb5dl 70 59 . . . cord-324859-0yuhb5dl 71 1 Studies study NNS cord-324859-0yuhb5dl 71 2 published publish VBN cord-324859-0yuhb5dl 71 3 in in IN cord-324859-0yuhb5dl 71 4 non non JJ cord-324859-0yuhb5dl 71 5 - - JJ cord-324859-0yuhb5dl 71 6 English english JJ cord-324859-0yuhb5dl 71 7 languages language NNS cord-324859-0yuhb5dl 71 8 , , , cord-324859-0yuhb5dl 71 9 those those DT cord-324859-0yuhb5dl 71 10 without without IN cord-324859-0yuhb5dl 71 11 a a DT cord-324859-0yuhb5dl 71 12 comparator comparator NN cord-324859-0yuhb5dl 71 13 group group NN cord-324859-0yuhb5dl 71 14 , , , cord-324859-0yuhb5dl 71 15 clinical clinical JJ cord-324859-0yuhb5dl 71 16 trials trial NNS cord-324859-0yuhb5dl 71 17 with with IN cord-324859-0yuhb5dl 71 18 a a DT cord-324859-0yuhb5dl 71 19 pre pre JJ cord-324859-0yuhb5dl 71 20 - - JJ cord-324859-0yuhb5dl 71 21 post post JJ cord-324859-0yuhb5dl 71 22 design design NN cord-324859-0yuhb5dl 71 23 , , , cord-324859-0yuhb5dl 71 24 case case NN cord-324859-0yuhb5dl 71 25 reports report NNS cord-324859-0yuhb5dl 71 26 and and CC cord-324859-0yuhb5dl 71 27 systematic systematic JJ cord-324859-0yuhb5dl 71 28 and and CC cord-324859-0yuhb5dl 71 29 narrative narrative NN cord-324859-0yuhb5dl 71 30 reviews review NNS cord-324859-0yuhb5dl 71 31 were be VBD cord-324859-0yuhb5dl 71 32 not not RB cord-324859-0yuhb5dl 71 33 eligible eligible JJ cord-324859-0yuhb5dl 71 34 for for IN cord-324859-0yuhb5dl 71 35 inclusion inclusion NN cord-324859-0yuhb5dl 71 36 . . . cord-324859-0yuhb5dl 72 1 Small small JJ cord-324859-0yuhb5dl 72 2 case case NN cord-324859-0yuhb5dl 72 3 series series NN cord-324859-0yuhb5dl 72 4 and and CC cord-324859-0yuhb5dl 72 5 case case NN cord-324859-0yuhb5dl 72 6 reports report NNS cord-324859-0yuhb5dl 72 7 involving involve VBG cord-324859-0yuhb5dl 72 8 less less JJR cord-324859-0yuhb5dl 72 9 than than IN cord-324859-0yuhb5dl 72 10 10 10 CD cord-324859-0yuhb5dl 72 11 patients patient NNS cord-324859-0yuhb5dl 72 12 were be VBD cord-324859-0yuhb5dl 72 13 excluded exclude VBN cord-324859-0yuhb5dl 72 14 to to TO cord-324859-0yuhb5dl 72 15 minimize minimize VB cord-324859-0yuhb5dl 72 16 bias bias NN cord-324859-0yuhb5dl 72 17 . . . cord-324859-0yuhb5dl 73 1 Eligible eligible JJ cord-324859-0yuhb5dl 73 2 studies study NNS cord-324859-0yuhb5dl 73 3 were be VBD cord-324859-0yuhb5dl 73 4 imported import VBN cord-324859-0yuhb5dl 73 5 into into IN cord-324859-0yuhb5dl 73 6 a a DT cord-324859-0yuhb5dl 73 7 reference reference NN cord-324859-0yuhb5dl 73 8 manager manager NN cord-324859-0yuhb5dl 73 9 ( ( -LRB- cord-324859-0yuhb5dl 73 10 Zotero Zotero NNP cord-324859-0yuhb5dl 73 11 version version NN cord-324859-0yuhb5dl 73 12 5.0 5.0 CD cord-324859-0yuhb5dl 73 13 ) ) -RRB- cord-324859-0yuhb5dl 73 14 for for IN cord-324859-0yuhb5dl 73 15 sorting sorting NN cord-324859-0yuhb5dl 73 16 and and CC cord-324859-0yuhb5dl 73 17 removal removal NN cord-324859-0yuhb5dl 73 18 of of IN cord-324859-0yuhb5dl 73 19 duplicates duplicate NNS cord-324859-0yuhb5dl 73 20 . . . cord-324859-0yuhb5dl 74 1 At at IN cord-324859-0yuhb5dl 74 2 level level NN cord-324859-0yuhb5dl 74 3 1 1 CD cord-324859-0yuhb5dl 74 4 , , , cord-324859-0yuhb5dl 74 5 titles title NNS cord-324859-0yuhb5dl 74 6 and and CC cord-324859-0yuhb5dl 74 7 abstracts abstract NNS cord-324859-0yuhb5dl 74 8 of of IN cord-324859-0yuhb5dl 74 9 all all PDT cord-324859-0yuhb5dl 74 10 the the DT cord-324859-0yuhb5dl 74 11 retrieved retrieve VBN cord-324859-0yuhb5dl 74 12 articles article NNS cord-324859-0yuhb5dl 74 13 were be VBD cord-324859-0yuhb5dl 74 14 individually individually RB cord-324859-0yuhb5dl 74 15 screened screen VBN cord-324859-0yuhb5dl 74 16 by by IN cord-324859-0yuhb5dl 74 17 two two CD cord-324859-0yuhb5dl 74 18 reviewers reviewer NNS cord-324859-0yuhb5dl 74 19 ( ( -LRB- cord-324859-0yuhb5dl 74 20 RM RM NNP cord-324859-0yuhb5dl 74 21 and and CC cord-324859-0yuhb5dl 74 22 AK AK NNP cord-324859-0yuhb5dl 74 23 ; ; : cord-324859-0yuhb5dl 74 24 RM RM NNP cord-324859-0yuhb5dl 74 25 and and CC cord-324859-0yuhb5dl 74 26 TL TL NNP cord-324859-0yuhb5dl 74 27 ) ) -RRB- cord-324859-0yuhb5dl 74 28 . . . cord-324859-0yuhb5dl 75 1 Full full JJ cord-324859-0yuhb5dl 75 2 texts text NNS cord-324859-0yuhb5dl 75 3 of of IN cord-324859-0yuhb5dl 75 4 studies study NNS cord-324859-0yuhb5dl 75 5 eligible eligible JJ cord-324859-0yuhb5dl 75 6 for for IN cord-324859-0yuhb5dl 75 7 inclusion inclusion NN cord-324859-0yuhb5dl 75 8 were be VBD cord-324859-0yuhb5dl 75 9 examined examine VBN cord-324859-0yuhb5dl 75 10 by by IN cord-324859-0yuhb5dl 75 11 two two CD cord-324859-0yuhb5dl 75 12 reviewers reviewer NNS cord-324859-0yuhb5dl 75 13 at at IN cord-324859-0yuhb5dl 75 14 level level NN cord-324859-0yuhb5dl 75 15 2 2 CD cord-324859-0yuhb5dl 75 16 , , , cord-324859-0yuhb5dl 75 17 and and CC cord-324859-0yuhb5dl 75 18 discrepancies discrepancy NNS cord-324859-0yuhb5dl 75 19 were be VBD cord-324859-0yuhb5dl 75 20 resolved resolve VBN cord-324859-0yuhb5dl 75 21 through through IN cord-324859-0yuhb5dl 75 22 mutual mutual JJ cord-324859-0yuhb5dl 75 23 consensus consensus NN cord-324859-0yuhb5dl 75 24 among among IN cord-324859-0yuhb5dl 75 25 the the DT cord-324859-0yuhb5dl 75 26 team team NN cord-324859-0yuhb5dl 75 27 members member NNS cord-324859-0yuhb5dl 75 28 . . . cord-324859-0yuhb5dl 76 1 In in IN cord-324859-0yuhb5dl 76 2 case case NN cord-324859-0yuhb5dl 76 3 of of IN cord-324859-0yuhb5dl 76 4 a a DT cord-324859-0yuhb5dl 76 5 suspected suspect VBN cord-324859-0yuhb5dl 76 6 patient patient NN cord-324859-0yuhb5dl 76 7 overlap overlap NN cord-324859-0yuhb5dl 76 8 across across IN cord-324859-0yuhb5dl 76 9 studies study NNS cord-324859-0yuhb5dl 76 10 , , , cord-324859-0yuhb5dl 76 11 the the DT cord-324859-0yuhb5dl 76 12 respective respective JJ cord-324859-0yuhb5dl 76 13 authors author NNS cord-324859-0yuhb5dl 76 14 were be VBD cord-324859-0yuhb5dl 76 15 contacted contact VBN cord-324859-0yuhb5dl 76 16 and and CC cord-324859-0yuhb5dl 76 17 requested request VBN cord-324859-0yuhb5dl 76 18 for for IN cord-324859-0yuhb5dl 76 19 clarification clarification NN cord-324859-0yuhb5dl 76 20 . . . cord-324859-0yuhb5dl 77 1 Two two CD cord-324859-0yuhb5dl 77 2 further further JJ cord-324859-0yuhb5dl 77 3 reminders reminder NNS cord-324859-0yuhb5dl 77 4 were be VBD cord-324859-0yuhb5dl 77 5 sent send VBN cord-324859-0yuhb5dl 77 6 in in IN cord-324859-0yuhb5dl 77 7 case case NN cord-324859-0yuhb5dl 77 8 no no DT cord-324859-0yuhb5dl 77 9 reply reply NN cord-324859-0yuhb5dl 77 10 was be VBD cord-324859-0yuhb5dl 77 11 received receive VBN cord-324859-0yuhb5dl 77 12 to to IN cord-324859-0yuhb5dl 77 13 the the DT cord-324859-0yuhb5dl 77 14 initial initial JJ cord-324859-0yuhb5dl 77 15 queries query NNS cord-324859-0yuhb5dl 77 16 . . . cord-324859-0yuhb5dl 78 1 Data data NN cord-324859-0yuhb5dl 78 2 extraction extraction NN cord-324859-0yuhb5dl 78 3 was be VBD cord-324859-0yuhb5dl 78 4 undertaken undertake VBN cord-324859-0yuhb5dl 78 5 independently independently RB cord-324859-0yuhb5dl 78 6 by by IN cord-324859-0yuhb5dl 78 7 RM RM NNP cord-324859-0yuhb5dl 78 8 and and CC cord-324859-0yuhb5dl 78 9 AK AK NNP cord-324859-0yuhb5dl 78 10 , , , cord-324859-0yuhb5dl 78 11 and and CC cord-324859-0yuhb5dl 78 12 a a DT cord-324859-0yuhb5dl 78 13 data data NN cord-324859-0yuhb5dl 78 14 extraction extraction NN cord-324859-0yuhb5dl 78 15 form form NN cord-324859-0yuhb5dl 78 16 was be VBD cord-324859-0yuhb5dl 78 17 prepared prepare VBN cord-324859-0yuhb5dl 78 18 in in IN cord-324859-0yuhb5dl 78 19 Microsoft Microsoft NNP cord-324859-0yuhb5dl 78 20 Excel Excel NNP cord-324859-0yuhb5dl 78 21 based base VBN cord-324859-0yuhb5dl 78 22 on on IN cord-324859-0yuhb5dl 78 23 the the DT cord-324859-0yuhb5dl 78 24 Cochrane Cochrane NNP cord-324859-0yuhb5dl 78 25 Handbook Handbook NNP cord-324859-0yuhb5dl 78 26 of of IN cord-324859-0yuhb5dl 78 27 Recommendations Recommendations NNPS cord-324859-0yuhb5dl 78 28 . . . cord-324859-0yuhb5dl 79 1 Information information NN cord-324859-0yuhb5dl 79 2 on on IN cord-324859-0yuhb5dl 79 3 author author NN cord-324859-0yuhb5dl 79 4 names name NNS cord-324859-0yuhb5dl 79 5 , , , cord-324859-0yuhb5dl 79 6 month month NN cord-324859-0yuhb5dl 79 7 of of IN cord-324859-0yuhb5dl 79 8 publication publication NN cord-324859-0yuhb5dl 79 9 , , , cord-324859-0yuhb5dl 79 10 country country NN cord-324859-0yuhb5dl 79 11 , , , cord-324859-0yuhb5dl 79 12 study study NN cord-324859-0yuhb5dl 79 13 site site NN cord-324859-0yuhb5dl 79 14 , , , cord-324859-0yuhb5dl 79 15 study study NN cord-324859-0yuhb5dl 79 16 design design NN cord-324859-0yuhb5dl 79 17 , , , cord-324859-0yuhb5dl 79 18 enrolment enrolment NN cord-324859-0yuhb5dl 79 19 duration duration NN cord-324859-0yuhb5dl 79 20 , , , cord-324859-0yuhb5dl 79 21 patient patient JJ cord-324859-0yuhb5dl 79 22 demographics demographic NNS cord-324859-0yuhb5dl 79 23 ( ( -LRB- cord-324859-0yuhb5dl 79 24 age age NN cord-324859-0yuhb5dl 79 25 and and CC cord-324859-0yuhb5dl 79 26 sex sex NN cord-324859-0yuhb5dl 79 27 ) ) -RRB- cord-324859-0yuhb5dl 79 28 , , , cord-324859-0yuhb5dl 79 29 comorbidities comorbiditie NNS cord-324859-0yuhb5dl 79 30 , , , cord-324859-0yuhb5dl 79 31 sample sample NN cord-324859-0yuhb5dl 79 32 size size NN cord-324859-0yuhb5dl 79 33 , , , cord-324859-0yuhb5dl 79 34 levels level NNS cord-324859-0yuhb5dl 79 35 of of IN cord-324859-0yuhb5dl 79 36 the the DT cord-324859-0yuhb5dl 79 37 requisite requisite JJ cord-324859-0yuhb5dl 79 38 inflammatory inflammatory JJ cord-324859-0yuhb5dl 79 39 and and CC cord-324859-0yuhb5dl 79 40 immunological immunological JJ cord-324859-0yuhb5dl 79 41 markers marker NNS cord-324859-0yuhb5dl 79 42 and and CC cord-324859-0yuhb5dl 79 43 major major JJ cord-324859-0yuhb5dl 79 44 study study NN cord-324859-0yuhb5dl 79 45 findings finding NNS cord-324859-0yuhb5dl 79 46 were be VBD cord-324859-0yuhb5dl 79 47 recorded record VBN cord-324859-0yuhb5dl 79 48 for for IN cord-324859-0yuhb5dl 79 49 each each DT cord-324859-0yuhb5dl 79 50 study study NN cord-324859-0yuhb5dl 79 51 . . . cord-324859-0yuhb5dl 80 1 All all PDT cord-324859-0yuhb5dl 80 2 the the DT cord-324859-0yuhb5dl 80 3 eligible eligible JJ cord-324859-0yuhb5dl 80 4 studies study NNS cord-324859-0yuhb5dl 80 5 were be VBD cord-324859-0yuhb5dl 80 6 included include VBN cord-324859-0yuhb5dl 80 7 in in IN cord-324859-0yuhb5dl 80 8 the the DT cord-324859-0yuhb5dl 80 9 narrative narrative NN cord-324859-0yuhb5dl 80 10 synthesis synthesis NN cord-324859-0yuhb5dl 80 11 ; ; : cord-324859-0yuhb5dl 80 12 and and CC cord-324859-0yuhb5dl 80 13 studies study NNS cord-324859-0yuhb5dl 80 14 reporting report VBG cord-324859-0yuhb5dl 80 15 appropriate appropriate JJ cord-324859-0yuhb5dl 80 16 numeric numeric JJ cord-324859-0yuhb5dl 80 17 estimates estimate NNS cord-324859-0yuhb5dl 80 18 of of IN cord-324859-0yuhb5dl 80 19 the the DT cord-324859-0yuhb5dl 80 20 required require VBN cord-324859-0yuhb5dl 80 21 markers marker NNS cord-324859-0yuhb5dl 80 22 were be VBD cord-324859-0yuhb5dl 80 23 included include VBN cord-324859-0yuhb5dl 80 24 in in IN cord-324859-0yuhb5dl 80 25 the the DT cord-324859-0yuhb5dl 80 26 quantitative quantitative JJ cord-324859-0yuhb5dl 80 27 synthesis synthesis NN cord-324859-0yuhb5dl 80 28 . . . cord-324859-0yuhb5dl 81 1 Review Review NNP cord-324859-0yuhb5dl 81 2 Manager Manager NNP cord-324859-0yuhb5dl 81 3 software software NN cord-324859-0yuhb5dl 81 4 ( ( -LRB- cord-324859-0yuhb5dl 81 5 RevMan RevMan NNP cord-324859-0yuhb5dl 81 6 version version NN cord-324859-0yuhb5dl 81 7 5.3 5.3 CD cord-324859-0yuhb5dl 81 8 ) ) -RRB- cord-324859-0yuhb5dl 81 9 was be VBD cord-324859-0yuhb5dl 81 10 used use VBN cord-324859-0yuhb5dl 81 11 for for IN cord-324859-0yuhb5dl 81 12 a a DT cord-324859-0yuhb5dl 81 13 statistical statistical JJ cord-324859-0yuhb5dl 81 14 pooling pooling NN cord-324859-0yuhb5dl 81 15 of of IN cord-324859-0yuhb5dl 81 16 estimates estimate NNS cord-324859-0yuhb5dl 81 17 through through IN cord-324859-0yuhb5dl 81 18 a a DT cord-324859-0yuhb5dl 81 19 meta meta JJ cord-324859-0yuhb5dl 81 20 - - HYPH cord-324859-0yuhb5dl 81 21 analysis analysis NN cord-324859-0yuhb5dl 81 22 . . . cord-324859-0yuhb5dl 82 1 Outcomes outcome NNS cord-324859-0yuhb5dl 82 2 reported report VBD cord-324859-0yuhb5dl 82 3 as as IN cord-324859-0yuhb5dl 82 4 medians median NNS cord-324859-0yuhb5dl 82 5 and and CC cord-324859-0yuhb5dl 82 6 interquartile interquartile JJ cord-324859-0yuhb5dl 82 7 ranges range NNS cord-324859-0yuhb5dl 82 8 ( ( -LRB- cord-324859-0yuhb5dl 82 9 IQRs iqr NNS cord-324859-0yuhb5dl 82 10 ) ) -RRB- cord-324859-0yuhb5dl 82 11 were be VBD cord-324859-0yuhb5dl 82 12 converted convert VBN cord-324859-0yuhb5dl 82 13 to to IN cord-324859-0yuhb5dl 82 14 means mean NNS cord-324859-0yuhb5dl 82 15 and and CC cord-324859-0yuhb5dl 82 16 standard standard JJ cord-324859-0yuhb5dl 82 17 deviations deviation NNS cord-324859-0yuhb5dl 82 18 using use VBG cord-324859-0yuhb5dl 82 19 standard standard JJ cord-324859-0yuhb5dl 82 20 methods method NNS cord-324859-0yuhb5dl 82 21 , , , cord-324859-0yuhb5dl 82 22 20 20 CD cord-324859-0yuhb5dl 82 23 for for IN cord-324859-0yuhb5dl 82 24 statistical statistical JJ cord-324859-0yuhb5dl 82 25 uniformity uniformity NN cord-324859-0yuhb5dl 82 26 across across IN cord-324859-0yuhb5dl 82 27 study study NN cord-324859-0yuhb5dl 82 28 data datum NNS cord-324859-0yuhb5dl 82 29 . . . cord-324859-0yuhb5dl 83 1 The the DT cord-324859-0yuhb5dl 83 2 overall overall JJ cord-324859-0yuhb5dl 83 3 difference difference NN cord-324859-0yuhb5dl 83 4 in in IN cord-324859-0yuhb5dl 83 5 the the DT cord-324859-0yuhb5dl 83 6 average average JJ cord-324859-0yuhb5dl 83 7 value value NN cord-324859-0yuhb5dl 83 8 of of IN cord-324859-0yuhb5dl 83 9 each each DT cord-324859-0yuhb5dl 83 10 outcome outcome NN cord-324859-0yuhb5dl 83 11 between between IN cord-324859-0yuhb5dl 83 12 severe severe JJ cord-324859-0yuhb5dl 83 13 and and CC cord-324859-0yuhb5dl 83 14 non non JJ cord-324859-0yuhb5dl 83 15 - - JJ cord-324859-0yuhb5dl 83 16 severe severe JJ cord-324859-0yuhb5dl 83 17 groups group NNS cord-324859-0yuhb5dl 83 18 was be VBD cord-324859-0yuhb5dl 83 19 reported report VBN cord-324859-0yuhb5dl 83 20 as as IN cord-324859-0yuhb5dl 83 21 mean mean JJ cord-324859-0yuhb5dl 83 22 difference difference NN cord-324859-0yuhb5dl 83 23 ( ( -LRB- cord-324859-0yuhb5dl 83 24 MD MD NNP cord-324859-0yuhb5dl 83 25 ) ) -RRB- cord-324859-0yuhb5dl 83 26 along along IN cord-324859-0yuhb5dl 83 27 with with IN cord-324859-0yuhb5dl 83 28 95 95 CD cord-324859-0yuhb5dl 83 29 % % NN cord-324859-0yuhb5dl 83 30 confidence confidence NN cord-324859-0yuhb5dl 83 31 intervals interval NNS cord-324859-0yuhb5dl 83 32 ( ( -LRB- cord-324859-0yuhb5dl 83 33 CIs CIs NNP cord-324859-0yuhb5dl 83 34 ) ) -RRB- cord-324859-0yuhb5dl 83 35 . . . cord-324859-0yuhb5dl 84 1 Confidence confidence NN cord-324859-0yuhb5dl 84 2 intervals interval NNS cord-324859-0yuhb5dl 84 3 excluding exclude VBG cord-324859-0yuhb5dl 84 4 the the DT cord-324859-0yuhb5dl 84 5 null null JJ cord-324859-0yuhb5dl 84 6 value value NN cord-324859-0yuhb5dl 84 7 of of IN cord-324859-0yuhb5dl 84 8 0 0 CD cord-324859-0yuhb5dl 84 9 were be VBD cord-324859-0yuhb5dl 84 10 considered consider VBN cord-324859-0yuhb5dl 84 11 to to TO cord-324859-0yuhb5dl 84 12 be be VB cord-324859-0yuhb5dl 84 13 significant significant JJ cord-324859-0yuhb5dl 84 14 . . . cord-324859-0yuhb5dl 85 1 The the DT cord-324859-0yuhb5dl 85 2 pooled pool VBN cord-324859-0yuhb5dl 85 3 values value NNS cord-324859-0yuhb5dl 85 4 were be VBD cord-324859-0yuhb5dl 85 5 computed compute VBN cord-324859-0yuhb5dl 85 6 through through IN cord-324859-0yuhb5dl 85 7 random random JJ cord-324859-0yuhb5dl 85 8 - - HYPH cord-324859-0yuhb5dl 85 9 effect effect NN cord-324859-0yuhb5dl 85 10 models model NNS cord-324859-0yuhb5dl 85 11 ( ( -LRB- cord-324859-0yuhb5dl 85 12 REMs REMs NNP cord-324859-0yuhb5dl 85 13 ) ) -RRB- cord-324859-0yuhb5dl 85 14 , , , cord-324859-0yuhb5dl 85 15 using use VBG cord-324859-0yuhb5dl 85 16 the the DT cord-324859-0yuhb5dl 85 17 inverse inverse JJ cord-324859-0yuhb5dl 85 18 variance variance NN cord-324859-0yuhb5dl 85 19 method method NN cord-324859-0yuhb5dl 85 20 by by IN cord-324859-0yuhb5dl 85 21 DerSimonian DerSimonian NNP cord-324859-0yuhb5dl 85 22 and and CC cord-324859-0yuhb5dl 85 23 Laird Laird NNP cord-324859-0yuhb5dl 85 24 . . . cord-324859-0yuhb5dl 86 1 21 21 CD cord-324859-0yuhb5dl 87 1 Forest forest NN cord-324859-0yuhb5dl 87 2 plots plot NNS cord-324859-0yuhb5dl 87 3 were be VBD cord-324859-0yuhb5dl 87 4 generated generate VBN cord-324859-0yuhb5dl 87 5 to to TO cord-324859-0yuhb5dl 87 6 compare compare VB cord-324859-0yuhb5dl 87 7 the the DT cord-324859-0yuhb5dl 87 8 levels level NNS cord-324859-0yuhb5dl 87 9 of of IN cord-324859-0yuhb5dl 87 10 and and CC cord-324859-0yuhb5dl 87 11 quantify quantify VB cord-324859-0yuhb5dl 87 12 the the DT cord-324859-0yuhb5dl 87 13 difference difference NN cord-324859-0yuhb5dl 87 14 in in IN cord-324859-0yuhb5dl 87 15 each each DT cord-324859-0yuhb5dl 87 16 outcome outcome NN cord-324859-0yuhb5dl 87 17 , , , cord-324859-0yuhb5dl 87 18 between between IN cord-324859-0yuhb5dl 87 19 the the DT cord-324859-0yuhb5dl 87 20 two two CD cord-324859-0yuhb5dl 87 21 patient patient JJ cord-324859-0yuhb5dl 87 22 groups group NNS cord-324859-0yuhb5dl 87 23 . . . cord-324859-0yuhb5dl 88 1 Articles article NNS cord-324859-0yuhb5dl 88 2 that that WDT cord-324859-0yuhb5dl 88 3 did do VBD cord-324859-0yuhb5dl 88 4 not not RB cord-324859-0yuhb5dl 88 5 provide provide VB cord-324859-0yuhb5dl 88 6 numeric numeric JJ cord-324859-0yuhb5dl 88 7 estimates estimate NNS cord-324859-0yuhb5dl 88 8 were be VBD cord-324859-0yuhb5dl 88 9 excluded exclude VBN cord-324859-0yuhb5dl 88 10 from from IN cord-324859-0yuhb5dl 88 11 this this DT cord-324859-0yuhb5dl 88 12 meta meta NN cord-324859-0yuhb5dl 88 13 - - HYPH cord-324859-0yuhb5dl 88 14 analysis analysis NN cord-324859-0yuhb5dl 88 15 . . . cord-324859-0yuhb5dl 89 1 The the DT cord-324859-0yuhb5dl 89 2 confidence confidence NN cord-324859-0yuhb5dl 89 3 intervals interval NNS cord-324859-0yuhb5dl 89 4 of of IN cord-324859-0yuhb5dl 89 5 each each DT cord-324859-0yuhb5dl 89 6 study study NN cord-324859-0yuhb5dl 89 7 of of IN cord-324859-0yuhb5dl 89 8 each each DT cord-324859-0yuhb5dl 89 9 outcome outcome NN cord-324859-0yuhb5dl 89 10 were be VBD cord-324859-0yuhb5dl 89 11 visually visually RB cord-324859-0yuhb5dl 89 12 observed observe VBN cord-324859-0yuhb5dl 89 13 for for IN cord-324859-0yuhb5dl 89 14 the the DT cord-324859-0yuhb5dl 89 15 presence presence NN cord-324859-0yuhb5dl 89 16 of of IN cord-324859-0yuhb5dl 89 17 heterogeneity heterogeneity NN cord-324859-0yuhb5dl 89 18 , , , cord-324859-0yuhb5dl 89 19 indicated indicate VBN cord-324859-0yuhb5dl 89 20 by by IN cord-324859-0yuhb5dl 89 21 an an DT cord-324859-0yuhb5dl 89 22 overlap overlap NN cord-324859-0yuhb5dl 89 23 . . . cord-324859-0yuhb5dl 90 1 The the DT cord-324859-0yuhb5dl 90 2 magnitude magnitude NN cord-324859-0yuhb5dl 90 3 of of IN cord-324859-0yuhb5dl 90 4 variation variation NN cord-324859-0yuhb5dl 90 5 beyond beyond IN cord-324859-0yuhb5dl 90 6 chance chance NN cord-324859-0yuhb5dl 90 7 was be VBD cord-324859-0yuhb5dl 90 8 also also RB cord-324859-0yuhb5dl 90 9 objectively objectively RB cord-324859-0yuhb5dl 90 10 assessed assess VBN cord-324859-0yuhb5dl 90 11 using use VBG cord-324859-0yuhb5dl 90 12 the the DT cord-324859-0yuhb5dl 90 13 Cochran Cochran NNP cord-324859-0yuhb5dl 90 14 's 's POS cord-324859-0yuhb5dl 90 15 Q Q NNP cord-324859-0yuhb5dl 90 16 test test NN cord-324859-0yuhb5dl 90 17 , , , cord-324859-0yuhb5dl 90 18 22 22 CD cord-324859-0yuhb5dl 90 19 to to TO cord-324859-0yuhb5dl 90 20 ascertain ascertain VB cord-324859-0yuhb5dl 90 21 the the DT cord-324859-0yuhb5dl 90 22 level level NN cord-324859-0yuhb5dl 90 23 of of IN cord-324859-0yuhb5dl 90 24 overlap overlap NN cord-324859-0yuhb5dl 90 25 among among IN cord-324859-0yuhb5dl 90 26 the the DT cord-324859-0yuhb5dl 90 27 CIs ci NNS cord-324859-0yuhb5dl 90 28 of of IN cord-324859-0yuhb5dl 90 29 different different JJ cord-324859-0yuhb5dl 90 30 studies study NNS cord-324859-0yuhb5dl 90 31 . . . cord-324859-0yuhb5dl 91 1 Variability variability NN cord-324859-0yuhb5dl 91 2 in in IN cord-324859-0yuhb5dl 91 3 estimates estimate NNS cord-324859-0yuhb5dl 91 4 was be VBD cord-324859-0yuhb5dl 91 5 estimated estimate VBN cord-324859-0yuhb5dl 91 6 by by IN cord-324859-0yuhb5dl 91 7 the the DT cord-324859-0yuhb5dl 91 8 Higgins Higgins NNP cord-324859-0yuhb5dl 91 9 I i CD cord-324859-0yuhb5dl 91 10 2 2 CD cord-324859-0yuhb5dl 91 11 statistic statistic NN cord-324859-0yuhb5dl 91 12 , , , cord-324859-0yuhb5dl 91 13 used use VBN cord-324859-0yuhb5dl 91 14 to to TO cord-324859-0yuhb5dl 91 15 determine determine VB cord-324859-0yuhb5dl 91 16 the the DT cord-324859-0yuhb5dl 91 17 magnitude magnitude NN cord-324859-0yuhb5dl 91 18 of of IN cord-324859-0yuhb5dl 91 19 heterogeneity heterogeneity NN cord-324859-0yuhb5dl 91 20 across across IN cord-324859-0yuhb5dl 91 21 studies study NNS cord-324859-0yuhb5dl 91 22 . . . cord-324859-0yuhb5dl 92 1 A a DT cord-324859-0yuhb5dl 92 2 chi chi JJ cord-324859-0yuhb5dl 92 3 - - HYPH cord-324859-0yuhb5dl 92 4 square square JJ cord-324859-0yuhb5dl 92 5 P p NN cord-324859-0yuhb5dl 92 6 - - HYPH cord-324859-0yuhb5dl 92 7 value value NN cord-324859-0yuhb5dl 92 8 smaller small JJR cord-324859-0yuhb5dl 92 9 than than IN cord-324859-0yuhb5dl 92 10 .05 .05 NNP cord-324859-0yuhb5dl 92 11 was be VBD cord-324859-0yuhb5dl 92 12 considered consider VBN cord-324859-0yuhb5dl 92 13 statistically statistically RB cord-324859-0yuhb5dl 92 14 significant significant JJ cord-324859-0yuhb5dl 92 15 . . . cord-324859-0yuhb5dl 93 1 The the DT cord-324859-0yuhb5dl 93 2 Cochrane Cochrane NNP cord-324859-0yuhb5dl 93 3 Handbook Handbook NNP cord-324859-0yuhb5dl 93 4 cut cut NN cord-324859-0yuhb5dl 93 5 - - HYPH cord-324859-0yuhb5dl 93 6 offs off NNS cord-324859-0yuhb5dl 93 7 were be VBD cord-324859-0yuhb5dl 93 8 used use VBN cord-324859-0yuhb5dl 93 9 to to TO cord-324859-0yuhb5dl 93 10 ascertain ascertain VB cord-324859-0yuhb5dl 93 11 the the DT cord-324859-0yuhb5dl 93 12 degree degree NN cord-324859-0yuhb5dl 93 13 of of IN cord-324859-0yuhb5dl 93 14 heterogeneity heterogeneity NN cord-324859-0yuhb5dl 93 15 . . . cord-324859-0yuhb5dl 94 1 A a DT cord-324859-0yuhb5dl 94 2 sensitivity sensitivity NN cord-324859-0yuhb5dl 94 3 analysis analysis NN cord-324859-0yuhb5dl 94 4 was be VBD cord-324859-0yuhb5dl 94 5 also also RB cord-324859-0yuhb5dl 94 6 undertaken undertake VBN cord-324859-0yuhb5dl 94 7 to to TO cord-324859-0yuhb5dl 94 8 obtain obtain VB cord-324859-0yuhb5dl 94 9 pooled pool VBN cord-324859-0yuhb5dl 94 10 estimates estimate NNS cord-324859-0yuhb5dl 94 11 where where WRB cord-324859-0yuhb5dl 94 12 preprints preprint NNS cord-324859-0yuhb5dl 94 13 were be VBD cord-324859-0yuhb5dl 94 14 excluded exclude VBN cord-324859-0yuhb5dl 94 15 , , , cord-324859-0yuhb5dl 94 16 and and CC cord-324859-0yuhb5dl 94 17 only only RB cord-324859-0yuhb5dl 94 18 published publish VBN cord-324859-0yuhb5dl 94 19 studies study NNS cord-324859-0yuhb5dl 94 20 were be VBD cord-324859-0yuhb5dl 94 21 considered consider VBN cord-324859-0yuhb5dl 94 22 . . . cord-324859-0yuhb5dl 95 1 The the DT cord-324859-0yuhb5dl 95 2 Newcastle Newcastle NNP cord-324859-0yuhb5dl 95 3 - - HYPH cord-324859-0yuhb5dl 95 4 Ottawa Ottawa NNP cord-324859-0yuhb5dl 95 5 Scale Scale NNP cord-324859-0yuhb5dl 95 6 ( ( -LRB- cord-324859-0yuhb5dl 95 7 NOS NOS NNP cord-324859-0yuhb5dl 95 8 ) ) -RRB- cord-324859-0yuhb5dl 95 9 for for IN cord-324859-0yuhb5dl 95 10 cohort cohort NN cord-324859-0yuhb5dl 95 11 studies study NNS cord-324859-0yuhb5dl 95 12 , , , cord-324859-0yuhb5dl 95 13 as as IN cord-324859-0yuhb5dl 95 14 recommended recommend VBN cord-324859-0yuhb5dl 95 15 by by IN cord-324859-0yuhb5dl 95 16 Cochrane Cochrane NNP cord-324859-0yuhb5dl 95 17 , , , cord-324859-0yuhb5dl 95 18 23 23 CD cord-324859-0yuhb5dl 95 19 and and CC cord-324859-0yuhb5dl 95 20 the the DT cord-324859-0yuhb5dl 95 21 Joanna Joanna NNP cord-324859-0yuhb5dl 95 22 Briggs Briggs NNP cord-324859-0yuhb5dl 95 23 Institute Institute NNP cord-324859-0yuhb5dl 95 24 ( ( -LRB- cord-324859-0yuhb5dl 95 25 JBI JBI NNP cord-324859-0yuhb5dl 95 26 ) ) -RRB- cord-324859-0yuhb5dl 95 27 checklist checklist NN cord-324859-0yuhb5dl 95 28 24 24 CD cord-324859-0yuhb5dl 95 29 were be VBD cord-324859-0yuhb5dl 95 30 used use VBN cord-324859-0yuhb5dl 95 31 to to TO cord-324859-0yuhb5dl 95 32 assess assess VB cord-324859-0yuhb5dl 95 33 the the DT cord-324859-0yuhb5dl 95 34 level level NN cord-324859-0yuhb5dl 95 35 of of IN cord-324859-0yuhb5dl 95 36 bias bias NN cord-324859-0yuhb5dl 95 37 in in IN cord-324859-0yuhb5dl 95 38 the the DT cord-324859-0yuhb5dl 95 39 included include VBN cord-324859-0yuhb5dl 95 40 observational observational JJ cord-324859-0yuhb5dl 95 41 studies study NNS cord-324859-0yuhb5dl 95 42 . . . cord-324859-0yuhb5dl 96 1 We -PRON- PRP cord-324859-0yuhb5dl 96 2 used use VBD cord-324859-0yuhb5dl 96 3 a a DT cord-324859-0yuhb5dl 96 4 modified modify VBN cord-324859-0yuhb5dl 96 5 version version NN cord-324859-0yuhb5dl 96 6 of of IN cord-324859-0yuhb5dl 96 7 the the DT cord-324859-0yuhb5dl 96 8 NOS NOS NNP cord-324859-0yuhb5dl 96 9 for for IN cord-324859-0yuhb5dl 96 10 cohort cohort NN cord-324859-0yuhb5dl 96 11 studies study NNS cord-324859-0yuhb5dl 96 12 and and CC cord-324859-0yuhb5dl 96 13 removed remove VBD cord-324859-0yuhb5dl 96 14 two two CD cord-324859-0yuhb5dl 96 15 questions question NNS cord-324859-0yuhb5dl 96 16 on on IN cord-324859-0yuhb5dl 96 17 comparability comparability NN cord-324859-0yuhb5dl 96 18 of of IN cord-324859-0yuhb5dl 96 19 groups group NNS cord-324859-0yuhb5dl 96 20 and and CC cord-324859-0yuhb5dl 96 21 selection selection NN cord-324859-0yuhb5dl 96 22 of of IN cord-324859-0yuhb5dl 96 23 the the DT cord-324859-0yuhb5dl 96 24 non non JJ cord-324859-0yuhb5dl 96 25 - - JJ cord-324859-0yuhb5dl 96 26 exposed exposed JJ cord-324859-0yuhb5dl 96 27 cohort cohort NN cord-324859-0yuhb5dl 96 28 based base VBN cord-324859-0yuhb5dl 96 29 on on IN cord-324859-0yuhb5dl 96 30 relevance relevance NN cord-324859-0yuhb5dl 96 31 and and CC cord-324859-0yuhb5dl 96 32 to to TO cord-324859-0yuhb5dl 96 33 meet meet VB cord-324859-0yuhb5dl 96 34 our -PRON- PRP$ cord-324859-0yuhb5dl 96 35 study study NN cord-324859-0yuhb5dl 96 36 requirements requirement NNS cord-324859-0yuhb5dl 96 37 . . . cord-324859-0yuhb5dl 97 1 Two two CD cord-324859-0yuhb5dl 97 2 reviewers reviewer NNS cord-324859-0yuhb5dl 97 3 ( ( -LRB- cord-324859-0yuhb5dl 97 4 RM RM NNP cord-324859-0yuhb5dl 97 5 and and CC cord-324859-0yuhb5dl 97 6 AK AK NNP cord-324859-0yuhb5dl 97 7 ) ) -RRB- cord-324859-0yuhb5dl 97 8 independently independently RB cord-324859-0yuhb5dl 97 9 graded grade VBD cord-324859-0yuhb5dl 97 10 each each DT cord-324859-0yuhb5dl 97 11 study study NN cord-324859-0yuhb5dl 97 12 , , , cord-324859-0yuhb5dl 97 13 and and CC cord-324859-0yuhb5dl 97 14 disagreements disagreement NNS cord-324859-0yuhb5dl 97 15 were be VBD cord-324859-0yuhb5dl 97 16 resolved resolve VBN cord-324859-0yuhb5dl 97 17 by by IN cord-324859-0yuhb5dl 97 18 consensus consensus NN cord-324859-0yuhb5dl 97 19 . . . cord-324859-0yuhb5dl 98 1 Further further RB cord-324859-0yuhb5dl 98 2 , , , cord-324859-0yuhb5dl 98 3 funnel funnel VB cord-324859-0yuhb5dl 98 4 plots plot NNS cord-324859-0yuhb5dl 98 5 were be VBD cord-324859-0yuhb5dl 98 6 generated generate VBN cord-324859-0yuhb5dl 98 7 to to TO cord-324859-0yuhb5dl 98 8 visually visually RB cord-324859-0yuhb5dl 98 9 assess assess VB cord-324859-0yuhb5dl 98 10 the the DT cord-324859-0yuhb5dl 98 11 presence presence NN cord-324859-0yuhb5dl 98 12 of of IN cord-324859-0yuhb5dl 98 13 a a DT cord-324859-0yuhb5dl 98 14 publication publication NN cord-324859-0yuhb5dl 98 15 bias bias NN cord-324859-0yuhb5dl 98 16 among among IN cord-324859-0yuhb5dl 98 17 studies study NNS cord-324859-0yuhb5dl 98 18 . . . cord-324859-0yuhb5dl 99 1 Bias Bias NNP cord-324859-0yuhb5dl 99 2 was be VBD cord-324859-0yuhb5dl 99 3 also also RB cord-324859-0yuhb5dl 99 4 detected detect VBN cord-324859-0yuhb5dl 99 5 statistically statistically RB cord-324859-0yuhb5dl 99 6 by by IN cord-324859-0yuhb5dl 99 7 Egger Egger NNP cord-324859-0yuhb5dl 99 8 's 's POS cord-324859-0yuhb5dl 99 9 test test NN cord-324859-0yuhb5dl 99 10 , , , cord-324859-0yuhb5dl 99 11 25 25 CD cord-324859-0yuhb5dl 99 12 using use VBG cord-324859-0yuhb5dl 99 13 Stata Stata NNP cord-324859-0yuhb5dl 99 14 version version NN cord-324859-0yuhb5dl 99 15 15.1 15.1 CD cord-324859-0yuhb5dl 99 16 . . . cord-324859-0yuhb5dl 100 1 Our -PRON- PRP$ cord-324859-0yuhb5dl 100 2 database database NN cord-324859-0yuhb5dl 100 3 search search NN cord-324859-0yuhb5dl 100 4 identified identify VBD cord-324859-0yuhb5dl 100 5 a a DT cord-324859-0yuhb5dl 100 6 total total NN cord-324859-0yuhb5dl 100 7 of of IN cord-324859-0yuhb5dl 100 8 893 893 CD cord-324859-0yuhb5dl 100 9 records record NNS cord-324859-0yuhb5dl 100 10 ( ( -LRB- cord-324859-0yuhb5dl 100 11 Figure figure NN cord-324859-0yuhb5dl 100 12 1 1 CD cord-324859-0yuhb5dl 100 13 ) ) -RRB- cord-324859-0yuhb5dl 100 14 . . . cord-324859-0yuhb5dl 101 1 After after IN cord-324859-0yuhb5dl 101 2 removal removal NN cord-324859-0yuhb5dl 101 3 of of IN cord-324859-0yuhb5dl 101 4 duplicates duplicate NNS cord-324859-0yuhb5dl 101 5 , , , cord-324859-0yuhb5dl 101 6 861 861 CD cord-324859-0yuhb5dl 101 7 articles article NNS cord-324859-0yuhb5dl 101 8 were be VBD cord-324859-0yuhb5dl 101 9 screened screen VBN cord-324859-0yuhb5dl 101 10 on on IN cord-324859-0yuhb5dl 101 11 the the DT cord-324859-0yuhb5dl 101 12 basis basis NN cord-324859-0yuhb5dl 101 13 of of IN cord-324859-0yuhb5dl 101 14 their -PRON- PRP$ cord-324859-0yuhb5dl 101 15 titles title NNS cord-324859-0yuhb5dl 101 16 and and CC cord-324859-0yuhb5dl 101 17 abstracts abstract NNS cord-324859-0yuhb5dl 101 18 , , , cord-324859-0yuhb5dl 101 19 following follow VBG cord-324859-0yuhb5dl 101 20 which which WDT cord-324859-0yuhb5dl 101 21 full full JJ cord-324859-0yuhb5dl 101 22 texts text NNS cord-324859-0yuhb5dl 101 23 of of IN cord-324859-0yuhb5dl 101 24 209 209 CD cord-324859-0yuhb5dl 101 25 studies study NNS cord-324859-0yuhb5dl 101 26 were be VBD cord-324859-0yuhb5dl 101 27 assessed assess VBN cord-324859-0yuhb5dl 101 28 for for IN cord-324859-0yuhb5dl 101 29 eligibility eligibility NN cord-324859-0yuhb5dl 101 30 in in IN cord-324859-0yuhb5dl 101 31 the the DT cord-324859-0yuhb5dl 101 32 review review NN cord-324859-0yuhb5dl 101 33 . . . cord-324859-0yuhb5dl 102 1 A a DT cord-324859-0yuhb5dl 102 2 total total NN cord-324859-0yuhb5dl 102 3 of of IN cord-324859-0yuhb5dl 102 4 40 40 CD cord-324859-0yuhb5dl 102 5 studies study NNS cord-324859-0yuhb5dl 102 6 were be VBD cord-324859-0yuhb5dl 102 7 included include VBN cord-324859-0yuhb5dl 102 8 in in IN cord-324859-0yuhb5dl 102 9 the the DT cord-324859-0yuhb5dl 102 10 narrative narrative NN cord-324859-0yuhb5dl 102 11 synthesis synthesis NN cord-324859-0yuhb5dl 102 12 , , , cord-324859-0yuhb5dl 102 13 and and CC cord-324859-0yuhb5dl 102 14 25 25 CD cord-324859-0yuhb5dl 102 15 of of IN cord-324859-0yuhb5dl 102 16 them -PRON- PRP cord-324859-0yuhb5dl 102 17 contributed contribute VBD cord-324859-0yuhb5dl 102 18 to to IN cord-324859-0yuhb5dl 102 19 the the DT cord-324859-0yuhb5dl 102 20 metaanalysis metaanalysis NN cord-324859-0yuhb5dl 102 21 . . . cord-324859-0yuhb5dl 103 1 A a DT cord-324859-0yuhb5dl 103 2 few few JJ cord-324859-0yuhb5dl 103 3 studies study NNS cord-324859-0yuhb5dl 103 4 with with IN cord-324859-0yuhb5dl 103 5 three three CD cord-324859-0yuhb5dl 103 6 different different JJ cord-324859-0yuhb5dl 103 7 severity severity NN cord-324859-0yuhb5dl 103 8 groups group NNS cord-324859-0yuhb5dl 103 9 instead instead RB cord-324859-0yuhb5dl 103 10 of of IN cord-324859-0yuhb5dl 103 11 two two CD cord-324859-0yuhb5dl 103 12 , , , cord-324859-0yuhb5dl 103 13 as as RB cord-324859-0yuhb5dl 103 14 well well RB cord-324859-0yuhb5dl 103 15 as as IN cord-324859-0yuhb5dl 103 16 those those DT cord-324859-0yuhb5dl 103 17 that that WDT cord-324859-0yuhb5dl 103 18 did do VBD cord-324859-0yuhb5dl 103 19 not not RB cord-324859-0yuhb5dl 103 20 provide provide VB cord-324859-0yuhb5dl 103 21 appropriate appropriate JJ cord-324859-0yuhb5dl 103 22 numeric numeric JJ cord-324859-0yuhb5dl 103 23 estimates estimate NNS cord-324859-0yuhb5dl 103 24 , , , cord-324859-0yuhb5dl 103 25 were be VBD cord-324859-0yuhb5dl 103 26 excluded exclude VBN cord-324859-0yuhb5dl 103 27 from from IN cord-324859-0yuhb5dl 103 28 the the DT cord-324859-0yuhb5dl 103 29 quantitative quantitative JJ cord-324859-0yuhb5dl 103 30 synthesis synthesis NN cord-324859-0yuhb5dl 103 31 . . . cord-324859-0yuhb5dl 104 1 The the DT cord-324859-0yuhb5dl 104 2 following follow VBG cord-324859-0yuhb5dl 104 3 PRISMA PRISMA NNP cord-324859-0yuhb5dl 104 4 diagram diagram NN cord-324859-0yuhb5dl 104 5 lists list VBZ cord-324859-0yuhb5dl 104 6 the the DT cord-324859-0yuhb5dl 104 7 common common JJ cord-324859-0yuhb5dl 104 8 reasons reason NNS cord-324859-0yuhb5dl 104 9 for for IN cord-324859-0yuhb5dl 104 10 excluding exclude VBG cord-324859-0yuhb5dl 104 11 studies study NNS cord-324859-0yuhb5dl 104 12 and and CC cord-324859-0yuhb5dl 104 13 demonstrates demonstrate VBZ cord-324859-0yuhb5dl 104 14 the the DT cord-324859-0yuhb5dl 104 15 study study NN cord-324859-0yuhb5dl 104 16 selection selection NN cord-324859-0yuhb5dl 104 17 process process NN cord-324859-0yuhb5dl 104 18 for for IN cord-324859-0yuhb5dl 104 19 this this DT cord-324859-0yuhb5dl 104 20 review review NN cord-324859-0yuhb5dl 104 21 . . . cord-324859-0yuhb5dl 105 1 The the DT cord-324859-0yuhb5dl 105 2 descriptive descriptive JJ cord-324859-0yuhb5dl 105 3 characteristics characteristic NNS cord-324859-0yuhb5dl 105 4 of of IN cord-324859-0yuhb5dl 105 5 the the DT cord-324859-0yuhb5dl 105 6 included include VBN cord-324859-0yuhb5dl 105 7 studies study NNS cord-324859-0yuhb5dl 105 8 are be VBP cord-324859-0yuhb5dl 105 9 presented present VBN cord-324859-0yuhb5dl 105 10 in in IN cord-324859-0yuhb5dl 105 11 Table Table NNP cord-324859-0yuhb5dl 105 12 1 1 CD cord-324859-0yuhb5dl 105 13 . . . cord-324859-0yuhb5dl 106 1 The the DT cord-324859-0yuhb5dl 106 2 sample sample NN cord-324859-0yuhb5dl 106 3 size size NN cord-324859-0yuhb5dl 106 4 across across IN cord-324859-0yuhb5dl 106 5 all all PDT cord-324859-0yuhb5dl 106 6 the the DT cord-324859-0yuhb5dl 106 7 studies study NNS cord-324859-0yuhb5dl 106 8 ranged range VBD cord-324859-0yuhb5dl 106 9 from from IN cord-324859-0yuhb5dl 106 10 10 10 CD cord-324859-0yuhb5dl 106 11 patients patient NNS cord-324859-0yuhb5dl 106 12 to to IN cord-324859-0yuhb5dl 106 13 548 548 CD cord-324859-0yuhb5dl 106 14 patients patient NNS cord-324859-0yuhb5dl 106 15 , , , cord-324859-0yuhb5dl 106 16 and and CC cord-324859-0yuhb5dl 106 17 a a DT cord-324859-0yuhb5dl 106 18 total total NN cord-324859-0yuhb5dl 106 19 of of IN cord-324859-0yuhb5dl 106 20 5209 5209 CD cord-324859-0yuhb5dl 106 21 males male NNS cord-324859-0yuhb5dl 106 22 and and CC cord-324859-0yuhb5dl 106 23 females female NNS cord-324859-0yuhb5dl 106 24 participated participate VBD cord-324859-0yuhb5dl 106 25 in in IN cord-324859-0yuhb5dl 106 26 the the DT cord-324859-0yuhb5dl 106 27 40 40 CD cord-324859-0yuhb5dl 106 28 studies study NNS cord-324859-0yuhb5dl 106 29 included include VBN cord-324859-0yuhb5dl 106 30 in in IN cord-324859-0yuhb5dl 106 31 our -PRON- PRP$ cord-324859-0yuhb5dl 106 32 review review NN cord-324859-0yuhb5dl 106 33 . . . cord-324859-0yuhb5dl 107 1 Of of IN cord-324859-0yuhb5dl 107 2 the the DT cord-324859-0yuhb5dl 107 3 total total JJ cord-324859-0yuhb5dl 107 4 studies study NNS cord-324859-0yuhb5dl 107 5 , , , cord-324859-0yuhb5dl 107 6 35 35 CD cord-324859-0yuhb5dl 107 7 were be VBD cord-324859-0yuhb5dl 107 8 case case NN cord-324859-0yuhb5dl 107 9 series series NNP cord-324859-0yuhb5dl 107 10 7,26 7,26 NNP cord-324859-0yuhb5dl 107 11 - - HYPH cord-324859-0yuhb5dl 107 12 59 59 CD cord-324859-0yuhb5dl 107 13 and and CC cord-324859-0yuhb5dl 107 14 five five CD cord-324859-0yuhb5dl 107 15 were be VBD cord-324859-0yuhb5dl 107 16 retrospective retrospective JJ cord-324859-0yuhb5dl 107 17 cohorts cohort NNS cord-324859-0yuhb5dl 107 18 , , , cord-324859-0yuhb5dl 107 19 60 60 CD cord-324859-0yuhb5dl 107 20 - - SYM cord-324859-0yuhb5dl 107 21 64 64 CD cord-324859-0yuhb5dl 107 22 based base VBN cord-324859-0yuhb5dl 107 23 in in IN cord-324859-0yuhb5dl 107 24 hospitals hospital NNS cord-324859-0yuhb5dl 107 25 in in IN cord-324859-0yuhb5dl 107 26 different different JJ cord-324859-0yuhb5dl 107 27 parts part NNS cord-324859-0yuhb5dl 107 28 of of IN cord-324859-0yuhb5dl 107 29 China China NNP cord-324859-0yuhb5dl 107 30 . . . cord-324859-0yuhb5dl 108 1 The the DT cord-324859-0yuhb5dl 108 2 participants participant NNS cord-324859-0yuhb5dl 108 3 were be VBD cord-324859-0yuhb5dl 108 4 patients patient NNS cord-324859-0yuhb5dl 108 5 with with IN cord-324859-0yuhb5dl 108 6 a a DT cord-324859-0yuhb5dl 108 7 reverse reverse JJ cord-324859-0yuhb5dl 108 8 transcription transcription NN cord-324859-0yuhb5dl 108 9 - - HYPH cord-324859-0yuhb5dl 108 10 polymerase polymerase NN cord-324859-0yuhb5dl 108 11 chain chain NN cord-324859-0yuhb5dl 108 12 reaction reaction NN cord-324859-0yuhb5dl 108 13 ( ( -LRB- cord-324859-0yuhb5dl 108 14 RT RT NNP cord-324859-0yuhb5dl 108 15 - - HYPH cord-324859-0yuhb5dl 108 16 PCR)-confirmed pcr)-confirmed JJ cord-324859-0yuhb5dl 108 17 diagnosis diagnosis NN cord-324859-0yuhb5dl 108 18 of of IN cord-324859-0yuhb5dl 108 19 the the DT cord-324859-0yuhb5dl 108 20 novel novel JJ cord-324859-0yuhb5dl 108 21 coronavirus coronavirus NN cord-324859-0yuhb5dl 108 22 2019 2019 CD cord-324859-0yuhb5dl 108 23 , , , cord-324859-0yuhb5dl 108 24 enrolled enrol VBN cord-324859-0yuhb5dl 108 25 in in IN cord-324859-0yuhb5dl 108 26 the the DT cord-324859-0yuhb5dl 108 27 hospital hospital NN cord-324859-0yuhb5dl 108 28 within within IN cord-324859-0yuhb5dl 108 29 the the DT cord-324859-0yuhb5dl 108 30 four four CD cord-324859-0yuhb5dl 108 31 - - HYPH cord-324859-0yuhb5dl 108 32 month month NN cord-324859-0yuhb5dl 108 33 duration duration NN cord-324859-0yuhb5dl 108 34 of of IN cord-324859-0yuhb5dl 108 35 December December NNP cord-324859-0yuhb5dl 108 36 2019 2019 CD cord-324859-0yuhb5dl 108 37 to to IN cord-324859-0yuhb5dl 108 38 March March NNP cord-324859-0yuhb5dl 108 39 2020 2020 CD cord-324859-0yuhb5dl 108 40 . . . cord-324859-0yuhb5dl 109 1 Laboratory laboratory NN cord-324859-0yuhb5dl 109 2 assessments assessment NNS cord-324859-0yuhb5dl 109 3 of of IN cord-324859-0yuhb5dl 109 4 all all DT cord-324859-0yuhb5dl 109 5 confirmed confirm VBN cord-324859-0yuhb5dl 109 6 COVID-19 covid-19 CD cord-324859-0yuhb5dl 109 7 cases case NNS cord-324859-0yuhb5dl 109 8 were be VBD cord-324859-0yuhb5dl 109 9 baseline baseline JJ cord-324859-0yuhb5dl 109 10 measurements measurement NNS cord-324859-0yuhb5dl 109 11 undertaken undertake VBN cord-324859-0yuhb5dl 109 12 at at IN cord-324859-0yuhb5dl 109 13 the the DT cord-324859-0yuhb5dl 109 14 time time NN cord-324859-0yuhb5dl 109 15 of of IN cord-324859-0yuhb5dl 109 16 their -PRON- PRP$ cord-324859-0yuhb5dl 109 17 hospitalization hospitalization NN cord-324859-0yuhb5dl 109 18 . . . cord-324859-0yuhb5dl 110 1 The the DT cord-324859-0yuhb5dl 110 2 average average JJ cord-324859-0yuhb5dl 110 3 age age NN cord-324859-0yuhb5dl 110 4 of of IN cord-324859-0yuhb5dl 110 5 the the DT cord-324859-0yuhb5dl 110 6 patients patient NNS cord-324859-0yuhb5dl 110 7 ranged range VBD cord-324859-0yuhb5dl 110 8 from from IN cord-324859-0yuhb5dl 110 9 about about RB cord-324859-0yuhb5dl 110 10 40 40 CD cord-324859-0yuhb5dl 110 11 - - SYM cord-324859-0yuhb5dl 110 12 55 55 CD cord-324859-0yuhb5dl 110 13 years year NNS cord-324859-0yuhb5dl 110 14 in in IN cord-324859-0yuhb5dl 110 15 nearly nearly RB cord-324859-0yuhb5dl 110 16 three three CD cord-324859-0yuhb5dl 110 17 - - HYPH cord-324859-0yuhb5dl 110 18 quarters quarter NNS cord-324859-0yuhb5dl 110 19 of of IN cord-324859-0yuhb5dl 110 20 the the DT cord-324859-0yuhb5dl 110 21 studies study NNS cord-324859-0yuhb5dl 110 22 , , , cord-324859-0yuhb5dl 110 23 to to IN cord-324859-0yuhb5dl 110 24 over over IN cord-324859-0yuhb5dl 110 25 60 60 CD cord-324859-0yuhb5dl 110 26 years year NNS cord-324859-0yuhb5dl 110 27 in in IN cord-324859-0yuhb5dl 110 28 the the DT cord-324859-0yuhb5dl 110 29 remaining remain VBG cord-324859-0yuhb5dl 110 30 . . . cord-324859-0yuhb5dl 111 1 Almost almost RB cord-324859-0yuhb5dl 111 2 one one CD cord-324859-0yuhb5dl 111 3 - - HYPH cord-324859-0yuhb5dl 111 4 third third NN cord-324859-0yuhb5dl 111 5 of of IN cord-324859-0yuhb5dl 111 6 the the DT cord-324859-0yuhb5dl 111 7 patients patient NNS cord-324859-0yuhb5dl 111 8 in in IN cord-324859-0yuhb5dl 111 9 each each DT cord-324859-0yuhb5dl 111 10 study study NN cord-324859-0yuhb5dl 111 11 had have VBD cord-324859-0yuhb5dl 111 12 a a DT cord-324859-0yuhb5dl 111 13 comorbid comorbid JJ cord-324859-0yuhb5dl 111 14 condition condition NN cord-324859-0yuhb5dl 111 15 with with IN cord-324859-0yuhb5dl 111 16 heart heart NN cord-324859-0yuhb5dl 111 17 disease disease NN cord-324859-0yuhb5dl 111 18 , , , cord-324859-0yuhb5dl 111 19 diabetes diabetes NN cord-324859-0yuhb5dl 111 20 , , , cord-324859-0yuhb5dl 111 21 hypertension hypertension NN cord-324859-0yuhb5dl 111 22 , , , cord-324859-0yuhb5dl 111 23 and and CC cord-324859-0yuhb5dl 111 24 kidney kidney NN cord-324859-0yuhb5dl 111 25 disease disease NN cord-324859-0yuhb5dl 111 26 being be VBG cord-324859-0yuhb5dl 111 27 the the DT cord-324859-0yuhb5dl 111 28 most most RBS cord-324859-0yuhb5dl 111 29 prevalent prevalent JJ cord-324859-0yuhb5dl 111 30 ones one NNS cord-324859-0yuhb5dl 111 31 . . . cord-324859-0yuhb5dl 112 1 The the DT cord-324859-0yuhb5dl 112 2 most most RBS cord-324859-0yuhb5dl 112 3 common common JJ cord-324859-0yuhb5dl 112 4 symptoms symptom NNS cord-324859-0yuhb5dl 112 5 across across IN cord-324859-0yuhb5dl 112 6 studies study NNS cord-324859-0yuhb5dl 112 7 were be VBD cord-324859-0yuhb5dl 112 8 fever fever NN cord-324859-0yuhb5dl 112 9 , , , cord-324859-0yuhb5dl 112 10 cough cough NN cord-324859-0yuhb5dl 112 11 , , , cord-324859-0yuhb5dl 112 12 fatigue fatigue NN cord-324859-0yuhb5dl 112 13 , , , cord-324859-0yuhb5dl 112 14 dyspnea dyspnea NN cord-324859-0yuhb5dl 112 15 , , , cord-324859-0yuhb5dl 112 16 myalgia myalgia NN cord-324859-0yuhb5dl 112 17 and and CC cord-324859-0yuhb5dl 112 18 headache headache NN cord-324859-0yuhb5dl 112 19 . . . cord-324859-0yuhb5dl 113 1 A a DT cord-324859-0yuhb5dl 113 2 summary summary NN cord-324859-0yuhb5dl 113 3 of of IN cord-324859-0yuhb5dl 113 4 major major JJ cord-324859-0yuhb5dl 113 5 findings finding NNS cord-324859-0yuhb5dl 113 6 of of IN cord-324859-0yuhb5dl 113 7 each each DT cord-324859-0yuhb5dl 113 8 of of IN cord-324859-0yuhb5dl 113 9 the the DT cord-324859-0yuhb5dl 113 10 included include VBN cord-324859-0yuhb5dl 113 11 studies study NNS cord-324859-0yuhb5dl 113 12 is be VBZ cord-324859-0yuhb5dl 113 13 presented present VBN cord-324859-0yuhb5dl 113 14 in in IN cord-324859-0yuhb5dl 113 15 Table Table NNP cord-324859-0yuhb5dl 113 16 1 1 CD cord-324859-0yuhb5dl 113 17 . . . cord-324859-0yuhb5dl 114 1 Older old JJR cord-324859-0yuhb5dl 114 2 age age NN cord-324859-0yuhb5dl 114 3 , , , cord-324859-0yuhb5dl 114 4 presence presence NN cord-324859-0yuhb5dl 114 5 of of IN cord-324859-0yuhb5dl 114 6 comorbidities comorbiditie NNS cord-324859-0yuhb5dl 114 7 such such JJ cord-324859-0yuhb5dl 114 8 as as IN cord-324859-0yuhb5dl 114 9 cardiovascular cardiovascular JJ cord-324859-0yuhb5dl 114 10 disease disease NN cord-324859-0yuhb5dl 114 11 , , , cord-324859-0yuhb5dl 114 12 hypertension hypertension NN cord-324859-0yuhb5dl 114 13 and and CC cord-324859-0yuhb5dl 114 14 chronic chronic JJ cord-324859-0yuhb5dl 114 15 obstructive obstructive JJ cord-324859-0yuhb5dl 114 16 pulmonary pulmonary JJ cord-324859-0yuhb5dl 114 17 disease disease NN cord-324859-0yuhb5dl 114 18 , , , cord-324859-0yuhb5dl 114 19 and and CC cord-324859-0yuhb5dl 114 20 being be VBG cord-324859-0yuhb5dl 114 21 male male JJ cord-324859-0yuhb5dl 114 22 were be VBD cord-324859-0yuhb5dl 114 23 found find VBN cord-324859-0yuhb5dl 114 24 to to TO cord-324859-0yuhb5dl 114 25 be be VB cord-324859-0yuhb5dl 114 26 major major JJ cord-324859-0yuhb5dl 114 27 risk risk NN cord-324859-0yuhb5dl 114 28 factors factor NNS cord-324859-0yuhb5dl 114 29 for for IN cord-324859-0yuhb5dl 114 30 disease disease NN cord-324859-0yuhb5dl 114 31 severity severity NN cord-324859-0yuhb5dl 114 32 , , , cord-324859-0yuhb5dl 114 33 higher high JJR cord-324859-0yuhb5dl 114 34 complications complication NNS cord-324859-0yuhb5dl 114 35 and and CC cord-324859-0yuhb5dl 114 36 a a DT cord-324859-0yuhb5dl 114 37 greater great JJR cord-324859-0yuhb5dl 114 38 likelihood likelihood NN cord-324859-0yuhb5dl 114 39 of of IN cord-324859-0yuhb5dl 114 40 death death NN cord-324859-0yuhb5dl 114 41 . . . cord-324859-0yuhb5dl 115 1 Additionally additionally RB cord-324859-0yuhb5dl 115 2 , , , cord-324859-0yuhb5dl 115 3 patients patient NNS cord-324859-0yuhb5dl 115 4 in in IN cord-324859-0yuhb5dl 115 5 the the DT cord-324859-0yuhb5dl 115 6 severe severe JJ cord-324859-0yuhb5dl 115 7 groups group NNS cord-324859-0yuhb5dl 115 8 were be VBD cord-324859-0yuhb5dl 115 9 characterized characterize VBN cord-324859-0yuhb5dl 115 10 by by IN cord-324859-0yuhb5dl 115 11 lymphocytopenia lymphocytopenia NNP cord-324859-0yuhb5dl 115 12 ( ( -LRB- cord-324859-0yuhb5dl 115 13 low low JJ cord-324859-0yuhb5dl 115 14 CD3 CD3 NNP cord-324859-0yuhb5dl 115 15 + + CC cord-324859-0yuhb5dl 115 16 , , , cord-324859-0yuhb5dl 115 17 CD4 CD4 NNP cord-324859-0yuhb5dl 115 18 + + CC cord-324859-0yuhb5dl 115 19 and and CC cord-324859-0yuhb5dl 115 20 CD8 CD8 NNP cord-324859-0yuhb5dl 115 21 + + CC cord-324859-0yuhb5dl 115 22 T t NN cord-324859-0yuhb5dl 115 23 - - HYPH cord-324859-0yuhb5dl 115 24 cell cell NN cord-324859-0yuhb5dl 115 25 counts count NNS cord-324859-0yuhb5dl 115 26 ) ) -RRB- cord-324859-0yuhb5dl 115 27 , , , cord-324859-0yuhb5dl 115 28 leucocytosis leucocytosis NNP cord-324859-0yuhb5dl 115 29 , , , cord-324859-0yuhb5dl 115 30 higher high JJR cord-324859-0yuhb5dl 115 31 plasma plasma NN cord-324859-0yuhb5dl 115 32 levels level NNS cord-324859-0yuhb5dl 115 33 of of IN cord-324859-0yuhb5dl 115 34 infection infection NN cord-324859-0yuhb5dl 115 35 - - HYPH cord-324859-0yuhb5dl 115 36 related relate VBN cord-324859-0yuhb5dl 115 37 biomarkers biomarker NNS cord-324859-0yuhb5dl 115 38 such such JJ cord-324859-0yuhb5dl 115 39 as as IN cord-324859-0yuhb5dl 115 40 erythrocyte erythrocyte NN cord-324859-0yuhb5dl 115 41 sedimentation sedimentation NN cord-324859-0yuhb5dl 115 42 rate rate NN cord-324859-0yuhb5dl 115 43 ( ( -LRB- cord-324859-0yuhb5dl 115 44 ESR ESR NNP cord-324859-0yuhb5dl 115 45 ) ) -RRB- cord-324859-0yuhb5dl 115 46 , , , cord-324859-0yuhb5dl 115 47 C C NNP cord-324859-0yuhb5dl 115 48 - - HYPH cord-324859-0yuhb5dl 115 49 reactive reactive JJ cord-324859-0yuhb5dl 115 50 protein protein NN cord-324859-0yuhb5dl 115 51 and and CC cord-324859-0yuhb5dl 115 52 procalcitonin procalcitonin NNS cord-324859-0yuhb5dl 115 53 , , , cord-324859-0yuhb5dl 115 54 and and CC cord-324859-0yuhb5dl 115 55 enzymes enzyme NNS cord-324859-0yuhb5dl 115 56 such such JJ cord-324859-0yuhb5dl 115 57 as as IN cord-324859-0yuhb5dl 115 58 lactate lactate NN cord-324859-0yuhb5dl 115 59 dehydrogenase dehydrogenase NN cord-324859-0yuhb5dl 115 60 ( ( -LRB- cord-324859-0yuhb5dl 115 61 LDH LDH NNP cord-324859-0yuhb5dl 115 62 ) ) -RRB- cord-324859-0yuhb5dl 115 63 and and CC cord-324859-0yuhb5dl 115 64 alanine alanine JJ cord-324859-0yuhb5dl 115 65 aminotransferase aminotransferase NN cord-324859-0yuhb5dl 115 66 ( ( -LRB- cord-324859-0yuhb5dl 115 67 ALT ALT NNP cord-324859-0yuhb5dl 115 68 ) ) -RRB- cord-324859-0yuhb5dl 115 69 . . . cord-324859-0yuhb5dl 116 1 The the DT cord-324859-0yuhb5dl 116 2 inflammatory inflammatory JJ cord-324859-0yuhb5dl 116 3 cytokines cytokine NNS cord-324859-0yuhb5dl 116 4 , , , cord-324859-0yuhb5dl 116 5 especially especially RB cord-324859-0yuhb5dl 116 6 circulating circulate VBG cord-324859-0yuhb5dl 116 7 interleukins interleukin NNS cord-324859-0yuhb5dl 116 8 6 6 CD cord-324859-0yuhb5dl 116 9 , , , cord-324859-0yuhb5dl 116 10 8 8 CD cord-324859-0yuhb5dl 116 11 , , , cord-324859-0yuhb5dl 116 12 10 10 CD cord-324859-0yuhb5dl 116 13 , , , cord-324859-0yuhb5dl 116 14 2R 2R NNP cord-324859-0yuhb5dl 116 15 and and CC cord-324859-0yuhb5dl 116 16 TNF tnf NN cord-324859-0yuhb5dl 116 17 - - HYPH cord-324859-0yuhb5dl 116 18 alpha alpha NN cord-324859-0yuhb5dl 116 19 levels level NNS cord-324859-0yuhb5dl 116 20 were be VBD cord-324859-0yuhb5dl 116 21 significantly significantly RB cord-324859-0yuhb5dl 116 22 elevated elevate VBN cord-324859-0yuhb5dl 116 23 among among IN cord-324859-0yuhb5dl 116 24 severe severe JJ cord-324859-0yuhb5dl 116 25 / / SYM cord-324859-0yuhb5dl 116 26 critical critical JJ cord-324859-0yuhb5dl 116 27 cases case NNS cord-324859-0yuhb5dl 116 28 , , , cord-324859-0yuhb5dl 116 29 as as IN cord-324859-0yuhb5dl 116 30 compared compare VBN cord-324859-0yuhb5dl 116 31 to to IN cord-324859-0yuhb5dl 116 32 the the DT cord-324859-0yuhb5dl 116 33 mild mild JJ cord-324859-0yuhb5dl 116 34 - - HYPH cord-324859-0yuhb5dl 116 35 to to IN cord-324859-0yuhb5dl 116 36 - - HYPH cord-324859-0yuhb5dl 116 37 moderate moderate JJ cord-324859-0yuhb5dl 116 38 patients patient NNS cord-324859-0yuhb5dl 116 39 . . . cord-324859-0yuhb5dl 117 1 Lymphocytopenia Lymphocytopenia NNP cord-324859-0yuhb5dl 117 2 and and CC cord-324859-0yuhb5dl 117 3 a a DT cord-324859-0yuhb5dl 117 4 pro pro JJ cord-324859-0yuhb5dl 117 5 - - JJ cord-324859-0yuhb5dl 117 6 inflammatory inflammatory JJ cord-324859-0yuhb5dl 117 7 cytokine cytokine NN cord-324859-0yuhb5dl 117 8 storm storm NN cord-324859-0yuhb5dl 117 9 were be VBD cord-324859-0yuhb5dl 117 10 therefore therefore RB cord-324859-0yuhb5dl 117 11 considered consider VBN cord-324859-0yuhb5dl 117 12 to to TO cord-324859-0yuhb5dl 117 13 be be VB cord-324859-0yuhb5dl 117 14 the the DT cord-324859-0yuhb5dl 117 15 most most RBS cord-324859-0yuhb5dl 117 16 critical critical JJ cord-324859-0yuhb5dl 117 17 contributors contributor NNS cord-324859-0yuhb5dl 117 18 to to IN cord-324859-0yuhb5dl 117 19 adverse adverse JJ cord-324859-0yuhb5dl 117 20 clinical clinical JJ cord-324859-0yuhb5dl 117 21 outcomes outcome NNS cord-324859-0yuhb5dl 117 22 in in IN cord-324859-0yuhb5dl 117 23 patients patient NNS cord-324859-0yuhb5dl 117 24 of of IN cord-324859-0yuhb5dl 117 25 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 117 26 . . . cord-324859-0yuhb5dl 118 1 The the DT cord-324859-0yuhb5dl 118 2 studies study NNS cord-324859-0yuhb5dl 118 3 included include VBD cord-324859-0yuhb5dl 118 4 in in IN cord-324859-0yuhb5dl 118 5 the the DT cord-324859-0yuhb5dl 118 6 meta meta NNP cord-324859-0yuhb5dl 118 7 - - HYPH cord-324859-0yuhb5dl 118 8 analysis analysis NN cord-324859-0yuhb5dl 118 9 reported report VBD cord-324859-0yuhb5dl 118 10 various various JJ cord-324859-0yuhb5dl 118 11 outcomes outcome NNS cord-324859-0yuhb5dl 118 12 : : : cord-324859-0yuhb5dl 118 13 IL-6 IL-6 NNP cord-324859-0yuhb5dl 118 14 ( ( -LRB- cord-324859-0yuhb5dl 118 15 n n NN cord-324859-0yuhb5dl 118 16 = = SYM cord-324859-0yuhb5dl 118 17 21 21 CD cord-324859-0yuhb5dl 118 18 ) ) -RRB- cord-324859-0yuhb5dl 118 19 , , , cord-324859-0yuhb5dl 118 20 7 7 CD cord-324859-0yuhb5dl 118 21 _SP cord-324859-0yuhb5dl 118 22 The the DT cord-324859-0yuhb5dl 118 23 methodological methodological JJ cord-324859-0yuhb5dl 118 24 quality quality NN cord-324859-0yuhb5dl 118 25 of of IN cord-324859-0yuhb5dl 118 26 and and CC cord-324859-0yuhb5dl 118 27 the the DT cord-324859-0yuhb5dl 118 28 presence presence NN cord-324859-0yuhb5dl 118 29 of of IN cord-324859-0yuhb5dl 118 30 bias bias NN cord-324859-0yuhb5dl 118 31 among among IN cord-324859-0yuhb5dl 118 32 the the DT cord-324859-0yuhb5dl 118 33 studies study NNS cord-324859-0yuhb5dl 118 34 was be VBD cord-324859-0yuhb5dl 118 35 assessed assess VBN cord-324859-0yuhb5dl 118 36 using use VBG cord-324859-0yuhb5dl 118 37 the the DT cord-324859-0yuhb5dl 118 38 JBI JBI NNP cord-324859-0yuhb5dl 118 39 checklist checklist NN cord-324859-0yuhb5dl 118 40 for for IN cord-324859-0yuhb5dl 118 41 case case NN cord-324859-0yuhb5dl 118 42 series series NNP cord-324859-0yuhb5dl 118 43 and and CC cord-324859-0yuhb5dl 118 44 the the DT cord-324859-0yuhb5dl 118 45 NOS NOS NNP cord-324859-0yuhb5dl 118 46 for for IN cord-324859-0yuhb5dl 118 47 cohort cohort NN cord-324859-0yuhb5dl 118 48 studies study NNS cord-324859-0yuhb5dl 118 49 in in IN cord-324859-0yuhb5dl 118 50 our -PRON- PRP$ cord-324859-0yuhb5dl 118 51 review review NN cord-324859-0yuhb5dl 118 52 . . . cord-324859-0yuhb5dl 119 1 Out out IN cord-324859-0yuhb5dl 119 2 of of IN cord-324859-0yuhb5dl 119 3 the the DT cord-324859-0yuhb5dl 119 4 35 35 CD cord-324859-0yuhb5dl 119 5 case case NN cord-324859-0yuhb5dl 119 6 series series NN cord-324859-0yuhb5dl 119 7 , , , cord-324859-0yuhb5dl 119 8 29 29 CD cord-324859-0yuhb5dl 119 9 studies study NNS cord-324859-0yuhb5dl 119 10 showed show VBD cord-324859-0yuhb5dl 119 11 a a DT cord-324859-0yuhb5dl 119 12 low low JJ cord-324859-0yuhb5dl 119 13 - - HYPH cord-324859-0yuhb5dl 119 14 moderate moderate JJ cord-324859-0yuhb5dl 119 15 bias bias NN cord-324859-0yuhb5dl 119 16 and and CC cord-324859-0yuhb5dl 119 17 six six CD cord-324859-0yuhb5dl 119 18 studies study NNS cord-324859-0yuhb5dl 119 19 had have VBD cord-324859-0yuhb5dl 119 20 a a DT cord-324859-0yuhb5dl 119 21 high high JJ cord-324859-0yuhb5dl 119 22 risk risk NN cord-324859-0yuhb5dl 119 23 of of IN cord-324859-0yuhb5dl 119 24 bias bias NN cord-324859-0yuhb5dl 119 25 . . . cord-324859-0yuhb5dl 120 1 Major major JJ cord-324859-0yuhb5dl 120 2 factors factor NNS cord-324859-0yuhb5dl 120 3 contributing contribute VBG cord-324859-0yuhb5dl 120 4 to to IN cord-324859-0yuhb5dl 120 5 the the DT cord-324859-0yuhb5dl 120 6 sub sub JJ cord-324859-0yuhb5dl 120 7 - - JJ cord-324859-0yuhb5dl 120 8 optimal optimal JJ cord-324859-0yuhb5dl 120 9 study study NN cord-324859-0yuhb5dl 120 10 quality quality NN cord-324859-0yuhb5dl 120 11 were be VBD cord-324859-0yuhb5dl 120 12 a a DT cord-324859-0yuhb5dl 120 13 lack lack NN cord-324859-0yuhb5dl 120 14 of of IN cord-324859-0yuhb5dl 120 15 consecutive consecutive JJ cord-324859-0yuhb5dl 120 16 and and CC cord-324859-0yuhb5dl 120 17 complete complete JJ cord-324859-0yuhb5dl 120 18 inclusion inclusion NN cord-324859-0yuhb5dl 120 19 of of IN cord-324859-0yuhb5dl 120 20 participants participant NNS cord-324859-0yuhb5dl 120 21 or or CC cord-324859-0yuhb5dl 120 22 unclear unclear JJ cord-324859-0yuhb5dl 120 23 reporting reporting NN cord-324859-0yuhb5dl 120 24 of of IN cord-324859-0yuhb5dl 120 25 the the DT cord-324859-0yuhb5dl 120 26 same same JJ cord-324859-0yuhb5dl 120 27 , , , cord-324859-0yuhb5dl 120 28 inadequate inadequate JJ cord-324859-0yuhb5dl 120 29 description description NN cord-324859-0yuhb5dl 120 30 of of IN cord-324859-0yuhb5dl 120 31 the the DT cord-324859-0yuhb5dl 120 32 socio socio JJ cord-324859-0yuhb5dl 120 33 - - HYPH cord-324859-0yuhb5dl 120 34 demographic demographic JJ cord-324859-0yuhb5dl 120 35 characteristics characteristic NNS cord-324859-0yuhb5dl 120 36 of of IN cord-324859-0yuhb5dl 120 37 patients patient NNS cord-324859-0yuhb5dl 120 38 and and CC cord-324859-0yuhb5dl 120 39 paucity paucity NN cord-324859-0yuhb5dl 120 40 of of IN cord-324859-0yuhb5dl 120 41 information information NN cord-324859-0yuhb5dl 120 42 about about IN cord-324859-0yuhb5dl 120 43 the the DT cord-324859-0yuhb5dl 120 44 study study NN cord-324859-0yuhb5dl 120 45 sites site NNS cord-324859-0yuhb5dl 120 46 / / SYM cord-324859-0yuhb5dl 120 47 hospitals hospital NNS cord-324859-0yuhb5dl 120 48 . . . cord-324859-0yuhb5dl 121 1 A a DT cord-324859-0yuhb5dl 121 2 high high JJ cord-324859-0yuhb5dl 121 3 risk risk NN cord-324859-0yuhb5dl 121 4 of of IN cord-324859-0yuhb5dl 121 5 bias bias NN cord-324859-0yuhb5dl 121 6 emanated emanate VBD cord-324859-0yuhb5dl 121 7 from from IN cord-324859-0yuhb5dl 121 8 the the DT cord-324859-0yuhb5dl 121 9 recruitment recruitment NN cord-324859-0yuhb5dl 121 10 and and CC cord-324859-0yuhb5dl 121 11 selection selection NN cord-324859-0yuhb5dl 121 12 process process NN cord-324859-0yuhb5dl 121 13 as as RB cord-324859-0yuhb5dl 121 14 well well RB cord-324859-0yuhb5dl 121 15 as as IN cord-324859-0yuhb5dl 121 16 ambiguity ambiguity NN cord-324859-0yuhb5dl 121 17 in in IN cord-324859-0yuhb5dl 121 18 reporting report VBG cord-324859-0yuhb5dl 121 19 the the DT cord-324859-0yuhb5dl 121 20 same same JJ cord-324859-0yuhb5dl 121 21 , , , cord-324859-0yuhb5dl 121 22 across across IN cord-324859-0yuhb5dl 121 23 various various JJ cord-324859-0yuhb5dl 121 24 studies study NNS cord-324859-0yuhb5dl 121 25 . . . cord-324859-0yuhb5dl 122 1 Since since IN cord-324859-0yuhb5dl 122 2 a a DT cord-324859-0yuhb5dl 122 3 majority majority NN cord-324859-0yuhb5dl 122 4 of of IN cord-324859-0yuhb5dl 122 5 the the DT cord-324859-0yuhb5dl 122 6 studies study NNS cord-324859-0yuhb5dl 122 7 included include VBN cord-324859-0yuhb5dl 122 8 in in IN cord-324859-0yuhb5dl 122 9 this this DT cord-324859-0yuhb5dl 122 10 review review NN cord-324859-0yuhb5dl 122 11 were be VBD cord-324859-0yuhb5dl 122 12 case case NN cord-324859-0yuhb5dl 122 13 series series NN cord-324859-0yuhb5dl 122 14 , , , cord-324859-0yuhb5dl 122 15 the the DT cord-324859-0yuhb5dl 122 16 overall overall JJ cord-324859-0yuhb5dl 122 17 quality quality NN cord-324859-0yuhb5dl 122 18 of of IN cord-324859-0yuhb5dl 122 19 evidence evidence NN cord-324859-0yuhb5dl 122 20 was be VBD cord-324859-0yuhb5dl 122 21 not not RB cord-324859-0yuhb5dl 122 22 satisfactory satisfactory JJ cord-324859-0yuhb5dl 122 23 . . . cord-324859-0yuhb5dl 123 1 Out out IN cord-324859-0yuhb5dl 123 2 of of IN cord-324859-0yuhb5dl 123 3 the the DT cord-324859-0yuhb5dl 123 4 five five CD cord-324859-0yuhb5dl 123 5 retrospective retrospective JJ cord-324859-0yuhb5dl 123 6 cohorts cohort NNS cord-324859-0yuhb5dl 123 7 , , , cord-324859-0yuhb5dl 123 8 three three CD cord-324859-0yuhb5dl 123 9 studies study NNS cord-324859-0yuhb5dl 123 10 had have VBD cord-324859-0yuhb5dl 123 11 a a DT cord-324859-0yuhb5dl 123 12 moderate moderate JJ cord-324859-0yuhb5dl 123 13 level level NN cord-324859-0yuhb5dl 123 14 of of IN cord-324859-0yuhb5dl 123 15 bias bias NN cord-324859-0yuhb5dl 123 16 , , , cord-324859-0yuhb5dl 123 17 one one PRP cord-324859-0yuhb5dl 123 18 had have VBD cord-324859-0yuhb5dl 123 19 a a DT cord-324859-0yuhb5dl 123 20 high high JJ cord-324859-0yuhb5dl 123 21 risk risk NN cord-324859-0yuhb5dl 123 22 of of IN cord-324859-0yuhb5dl 123 23 bias bias NN cord-324859-0yuhb5dl 123 24 , , , cord-324859-0yuhb5dl 123 25 and and CC cord-324859-0yuhb5dl 123 26 one one CD cord-324859-0yuhb5dl 123 27 study study NN cord-324859-0yuhb5dl 123 28 had have VBD cord-324859-0yuhb5dl 123 29 a a DT cord-324859-0yuhb5dl 123 30 low low JJ cord-324859-0yuhb5dl 123 31 risk risk NN cord-324859-0yuhb5dl 123 32 of of IN cord-324859-0yuhb5dl 123 33 bias bias NN cord-324859-0yuhb5dl 123 34 . . . cord-324859-0yuhb5dl 124 1 The the DT cord-324859-0yuhb5dl 124 2 major major JJ cord-324859-0yuhb5dl 124 3 risk risk NN cord-324859-0yuhb5dl 124 4 of of IN cord-324859-0yuhb5dl 124 5 bias bias NN cord-324859-0yuhb5dl 124 6 in in IN cord-324859-0yuhb5dl 124 7 these these DT cord-324859-0yuhb5dl 124 8 resulted result VBD cord-324859-0yuhb5dl 124 9 from from IN cord-324859-0yuhb5dl 124 10 the the DT cord-324859-0yuhb5dl 124 11 non non JJ cord-324859-0yuhb5dl 124 12 - - JJ cord-324859-0yuhb5dl 124 13 representativeness representativeness NN cord-324859-0yuhb5dl 124 14 of of IN cord-324859-0yuhb5dl 124 15 the the DT cord-324859-0yuhb5dl 124 16 study study NN cord-324859-0yuhb5dl 124 17 cohorts cohort NNS cord-324859-0yuhb5dl 124 18 and and CC cord-324859-0yuhb5dl 124 19 gaps gap NNS cord-324859-0yuhb5dl 124 20 in in IN cord-324859-0yuhb5dl 124 21 reporting reporting NN cord-324859-0yuhb5dl 124 22 of of IN cord-324859-0yuhb5dl 124 23 study study NN cord-324859-0yuhb5dl 124 24 outcomes outcome NNS cord-324859-0yuhb5dl 124 25 , , , cord-324859-0yuhb5dl 124 26 in in IN cord-324859-0yuhb5dl 124 27 terms term NNS cord-324859-0yuhb5dl 124 28 of of IN cord-324859-0yuhb5dl 124 29 timing timing NN cord-324859-0yuhb5dl 124 30 , , , cord-324859-0yuhb5dl 124 31 assessment assessment NN cord-324859-0yuhb5dl 124 32 and and CC cord-324859-0yuhb5dl 124 33 follow follow NN cord-324859-0yuhb5dl 124 34 - - HYPH cord-324859-0yuhb5dl 124 35 up up RP cord-324859-0yuhb5dl 124 36 duration duration NN cord-324859-0yuhb5dl 124 37 . . . cord-324859-0yuhb5dl 125 1 The the DT cord-324859-0yuhb5dl 125 2 detailed detailed JJ cord-324859-0yuhb5dl 125 3 assessment assessment NN cord-324859-0yuhb5dl 125 4 of of IN cord-324859-0yuhb5dl 125 5 bias bias NN cord-324859-0yuhb5dl 125 6 is be VBZ cord-324859-0yuhb5dl 125 7 provided provide VBN cord-324859-0yuhb5dl 125 8 in in IN cord-324859-0yuhb5dl 125 9 File File NNP cord-324859-0yuhb5dl 125 10 S2 S2 NNP cord-324859-0yuhb5dl 125 11 . . . cord-324859-0yuhb5dl 126 1 We -PRON- PRP cord-324859-0yuhb5dl 126 2 undertook undertake VBD cord-324859-0yuhb5dl 126 3 a a DT cord-324859-0yuhb5dl 126 4 statistical statistical JJ cord-324859-0yuhb5dl 126 5 pooling pooling NN cord-324859-0yuhb5dl 126 6 of of IN cord-324859-0yuhb5dl 126 7 estimates estimate NNS cord-324859-0yuhb5dl 126 8 across across IN cord-324859-0yuhb5dl 126 9 23 23 CD cord-324859-0yuhb5dl 126 10 studies study NNS cord-324859-0yuhb5dl 126 11 , , , cord-324859-0yuhb5dl 126 12 to to TO cord-324859-0yuhb5dl 126 13 quantify quantify VB cord-324859-0yuhb5dl 126 14 the the DT cord-324859-0yuhb5dl 126 15 difference difference NN cord-324859-0yuhb5dl 126 16 in in IN cord-324859-0yuhb5dl 126 17 the the DT cord-324859-0yuhb5dl 126 18 levels level NNS cord-324859-0yuhb5dl 126 19 of of IN cord-324859-0yuhb5dl 126 20 various various JJ cord-324859-0yuhb5dl 126 21 COVID-19-related covid-19-related JJ cord-324859-0yuhb5dl 126 22 inflammatory inflammatory NN cord-324859-0yuhb5dl 126 23 ( ( -LRB- cord-324859-0yuhb5dl 126 24 IL-6 IL-6 NNP cord-324859-0yuhb5dl 126 25 , , , cord-324859-0yuhb5dl 126 26 IL-8 IL-8 NNP cord-324859-0yuhb5dl 126 27 , , , cord-324859-0yuhb5dl 126 28 IL-10 IL-10 NNP cord-324859-0yuhb5dl 126 29 , , , cord-324859-0yuhb5dl 126 30 IL-2R IL-2R NNP cord-324859-0yuhb5dl 126 31 and and CC cord-324859-0yuhb5dl 126 32 TNF TNF NNP cord-324859-0yuhb5dl 126 33 - - HYPH cord-324859-0yuhb5dl 126 34 alpha alpha NN cord-324859-0yuhb5dl 126 35 ) ) -RRB- cord-324859-0yuhb5dl 126 36 and and CC cord-324859-0yuhb5dl 126 37 immunological immunological JJ cord-324859-0yuhb5dl 126 38 markers marker NNS cord-324859-0yuhb5dl 126 39 ( ( -LRB- cord-324859-0yuhb5dl 126 40 CD4 CD4 NNP cord-324859-0yuhb5dl 126 41 + + CC cord-324859-0yuhb5dl 126 42 T T NNP cord-324859-0yuhb5dl 126 43 and and CC cord-324859-0yuhb5dl 126 44 Deceased Deceased NNP cord-324859-0yuhb5dl 126 45 were be VBD cord-324859-0yuhb5dl 126 46 older old JJR cord-324859-0yuhb5dl 126 47 males male NNS cord-324859-0yuhb5dl 126 48 with with IN cord-324859-0yuhb5dl 126 49 comorbidities comorbiditie NNS cord-324859-0yuhb5dl 126 50 , , , cord-324859-0yuhb5dl 126 51 ARDS ARDS NNP cord-324859-0yuhb5dl 126 52 , , , cord-324859-0yuhb5dl 126 53 sepsis sepsis NN cord-324859-0yuhb5dl 126 54 , , , cord-324859-0yuhb5dl 126 55 cardiac cardiac JJ cord-324859-0yuhb5dl 126 56 injury injury NN cord-324859-0yuhb5dl 126 57 , , , cord-324859-0yuhb5dl 126 58 heart heart NN cord-324859-0yuhb5dl 126 59 failure failure NN cord-324859-0yuhb5dl 126 60 and and CC cord-324859-0yuhb5dl 126 61 kidney kidney NN cord-324859-0yuhb5dl 126 62 injury injury NN cord-324859-0yuhb5dl 126 63 . . . cord-324859-0yuhb5dl 127 1 30 30 CD cord-324859-0yuhb5dl 127 2 55.5 55.5 CD cord-324859-0yuhb5dl 127 3 M M NNP cord-324859-0yuhb5dl 127 4 10 10 CD cord-324859-0yuhb5dl 127 5 % % NN cord-324859-0yuhb5dl 127 6 diabetes diabetes NN cord-324859-0yuhb5dl 127 7 and and CC cord-324859-0yuhb5dl 127 8 CVD CVD NNP cord-324859-0yuhb5dl 127 9 , , , cord-324859-0yuhb5dl 127 10 and and CC cord-324859-0yuhb5dl 127 11 23 23 CD cord-324859-0yuhb5dl 127 12 % % NN cord-324859-0yuhb5dl 127 13 hypertension hypertension NN cord-324859-0yuhb5dl 128 1 85 85 CD cord-324859-0yuhb5dl 128 2 70 70 CD cord-324859-0yuhb5dl 128 3 Refractory refractory JJ cord-324859-0yuhb5dl 128 4 patients patient NNS cord-324859-0yuhb5dl 128 5 had have VBD cord-324859-0yuhb5dl 128 6 an an DT cord-324859-0yuhb5dl 128 7 older old JJR cord-324859-0yuhb5dl 128 8 age age NN cord-324859-0yuhb5dl 128 9 ; ; : cord-324859-0yuhb5dl 128 10 male male JJ cord-324859-0yuhb5dl 128 11 sex sex NN cord-324859-0yuhb5dl 128 12 ; ; , cord-324859-0yuhb5dl 128 13 more more JJR cord-324859-0yuhb5dl 128 14 underlying underlying JJ cord-324859-0yuhb5dl 128 15 comorbidities comorbiditie NNS cord-324859-0yuhb5dl 128 16 ; ; : cord-324859-0yuhb5dl 128 17 lower low JJR cord-324859-0yuhb5dl 128 18 fever fever NN cord-324859-0yuhb5dl 128 19 incidence incidence NN cord-324859-0yuhb5dl 128 20 ; ; : cord-324859-0yuhb5dl 128 21 higher high JJR cord-324859-0yuhb5dl 128 22 incidence incidence NN cord-324859-0yuhb5dl 128 23 of of IN cord-324859-0yuhb5dl 128 24 breath breath NN cord-324859-0yuhb5dl 128 25 shortness shortness NN cord-324859-0yuhb5dl 128 26 ; ; : cord-324859-0yuhb5dl 128 27 high high JJ cord-324859-0yuhb5dl 128 28 levels level NNS cord-324859-0yuhb5dl 128 29 of of IN cord-324859-0yuhb5dl 128 30 neutrophil neutrophil NN cord-324859-0yuhb5dl 128 31 ( ( -LRB- cord-324859-0yuhb5dl 128 32 AST AST NNP cord-324859-0yuhb5dl 128 33 ) ) -RRB- cord-324859-0yuhb5dl 128 34 , , , cord-324859-0yuhb5dl 128 35 LDH LDH NNP cord-324859-0yuhb5dl 128 36 and and CC cord-324859-0yuhb5dl 128 37 C C NNP cord-324859-0yuhb5dl 128 38 - - HYPH cord-324859-0yuhb5dl 128 39 reactive reactive JJ cord-324859-0yuhb5dl 128 40 protein protein NN cord-324859-0yuhb5dl 128 41 ; ; : cord-324859-0yuhb5dl 128 42 and and CC cord-324859-0yuhb5dl 128 43 higher high JJR cord-324859-0yuhb5dl 128 44 incidence incidence NN cord-324859-0yuhb5dl 128 45 of of IN cord-324859-0yuhb5dl 128 46 bilateral bilateral JJ cord-324859-0yuhb5dl 128 47 pneumonia pneumonia NN cord-324859-0yuhb5dl 128 48 and and CC cord-324859-0yuhb5dl 128 49 pleural pleural JJ cord-324859-0yuhb5dl 128 50 effusion effusion NN cord-324859-0yuhb5dl 128 51 . . . cord-324859-0yuhb5dl 129 1 31 31 CD cord-324859-0yuhb5dl 129 2 63.7 63.7 CD cord-324859-0yuhb5dl 129 3 % % NN cord-324859-0yuhb5dl 129 4 M M NNP cord-324859-0yuhb5dl 129 5 4 4 CD cord-324859-0yuhb5dl 129 6 % % NN cord-324859-0yuhb5dl 129 7 diabetes diabete NNS cord-324859-0yuhb5dl 129 8 , , , cord-324859-0yuhb5dl 129 9 10 10 CD cord-324859-0yuhb5dl 129 10 % % NN cord-324859-0yuhb5dl 129 11 CVD CVD NNP cord-324859-0yuhb5dl 129 12 and and CC cord-324859-0yuhb5dl 129 13 20 20 CD cord-324859-0yuhb5dl 129 14 % % NN cord-324859-0yuhb5dl 129 15 hypertension hypertension NN cord-324859-0yuhb5dl 129 16 84 84 CD cord-324859-0yuhb5dl 129 17 117 117 CD cord-324859-0yuhb5dl 129 18 Older old JJR cord-324859-0yuhb5dl 129 19 age age NN cord-324859-0yuhb5dl 129 20 was be VBD cord-324859-0yuhb5dl 129 21 associated associate VBN cord-324859-0yuhb5dl 129 22 with with IN cord-324859-0yuhb5dl 129 23 greater great JJR cord-324859-0yuhb5dl 129 24 risk risk NN cord-324859-0yuhb5dl 129 25 of of IN cord-324859-0yuhb5dl 129 26 ARDS ARDS NNP cord-324859-0yuhb5dl 129 27 and and CC cord-324859-0yuhb5dl 129 28 death death NN cord-324859-0yuhb5dl 129 29 . . . cord-324859-0yuhb5dl 130 1 High high JJ cord-324859-0yuhb5dl 130 2 fever fever NN cord-324859-0yuhb5dl 130 3 was be VBD cord-324859-0yuhb5dl 130 4 associated associate VBN cord-324859-0yuhb5dl 130 5 with with IN cord-324859-0yuhb5dl 130 6 better well JJR cord-324859-0yuhb5dl 130 7 outcomes outcome NNS cord-324859-0yuhb5dl 130 8 . . . cord-324859-0yuhb5dl 131 1 60 60 CD cord-324859-0yuhb5dl 131 2 65.9 65.9 CD cord-324859-0yuhb5dl 131 3 % % NN cord-324859-0yuhb5dl 131 4 M M NNP cord-324859-0yuhb5dl 131 5 76.20 76.20 CD cord-324859-0yuhb5dl 131 6 % % NN cord-324859-0yuhb5dl 131 7 13 13 CD cord-324859-0yuhb5dl 131 8 8 8 CD cord-324859-0yuhb5dl 132 1 The the DT cord-324859-0yuhb5dl 132 2 most most RBS cord-324859-0yuhb5dl 132 3 common common JJ cord-324859-0yuhb5dl 132 4 characteristics characteristic NNS cord-324859-0yuhb5dl 132 5 on on IN cord-324859-0yuhb5dl 132 6 chest chest NN cord-324859-0yuhb5dl 132 7 CT CT NNP cord-324859-0yuhb5dl 132 8 were be VBD cord-324859-0yuhb5dl 132 9 ground ground NN cord-324859-0yuhb5dl 132 10 - - HYPH cord-324859-0yuhb5dl 132 11 glass glass NN cord-324859-0yuhb5dl 132 12 opacity opacity NN cord-324859-0yuhb5dl 132 13 and and CC cord-324859-0yuhb5dl 132 14 bilateral bilateral JJ cord-324859-0yuhb5dl 132 15 patchy patchy JJ cord-324859-0yuhb5dl 132 16 shadowing shadowing NN cord-324859-0yuhb5dl 132 17 . . . cord-324859-0yuhb5dl 133 1 The the DT cord-324859-0yuhb5dl 133 2 most most RBS cord-324859-0yuhb5dl 133 3 common common JJ cord-324859-0yuhb5dl 133 4 findings finding NNS cord-324859-0yuhb5dl 133 5 on on IN cord-324859-0yuhb5dl 133 6 laboratory laboratory NN cord-324859-0yuhb5dl 133 7 measurements measurement NNS cord-324859-0yuhb5dl 133 8 were be VBD cord-324859-0yuhb5dl 133 9 lymphocytopenia lymphocytopenia NNP cord-324859-0yuhb5dl 133 10 , , , cord-324859-0yuhb5dl 133 11 elevated elevated JJ cord-324859-0yuhb5dl 133 12 levels level NNS cord-324859-0yuhb5dl 133 13 of of IN cord-324859-0yuhb5dl 133 14 C c NN cord-324859-0yuhb5dl 133 15 - - HYPH cord-324859-0yuhb5dl 133 16 reactive reactive JJ cord-324859-0yuhb5dl 133 17 protein protein NN cord-324859-0yuhb5dl 133 18 and and CC cord-324859-0yuhb5dl 133 19 interleukin-6 interleukin-6 NNP cord-324859-0yuhb5dl 133 20 . . . cord-324859-0yuhb5dl 134 1 32 32 CD cord-324859-0yuhb5dl 134 2 53.6 53.6 CD cord-324859-0yuhb5dl 134 3 % % NN cord-324859-0yuhb5dl 134 4 M M NNP cord-324859-0yuhb5dl 134 5 13 13 CD cord-324859-0yuhb5dl 134 6 % % NN cord-324859-0yuhb5dl 134 7 21 21 CD cord-324859-0yuhb5dl 134 8 102 102 CD cord-324859-0yuhb5dl 134 9 Significant significant JJ cord-324859-0yuhb5dl 134 10 positive positive JJ cord-324859-0yuhb5dl 134 11 correlations correlation NNS cord-324859-0yuhb5dl 134 12 between between IN cord-324859-0yuhb5dl 134 13 CD4 CD4 NNP cord-324859-0yuhb5dl 134 14 + + CC cord-324859-0yuhb5dl 134 15 T T NNP cord-324859-0yuhb5dl 134 16 and and CC cord-324859-0yuhb5dl 134 17 CD8 CD8 NNP cord-324859-0yuhb5dl 134 18 + + CC cord-324859-0yuhb5dl 134 19 T T NNP cord-324859-0yuhb5dl 134 20 , , , cord-324859-0yuhb5dl 134 21 IL-6 IL-6 NNP cord-324859-0yuhb5dl 134 22 and and CC cord-324859-0yuhb5dl 134 23 IL-10 IL-10 NNP cord-324859-0yuhb5dl 134 24 in in IN cord-324859-0yuhb5dl 134 25 the the DT cord-324859-0yuhb5dl 134 26 mild mild JJ cord-324859-0yuhb5dl 134 27 group group NN cord-324859-0yuhb5dl 134 28 . . . cord-324859-0yuhb5dl 135 1 33 33 CD cord-324859-0yuhb5dl 135 2 Older old JJR cord-324859-0yuhb5dl 135 3 age age NN cord-324859-0yuhb5dl 135 4 , , , cord-324859-0yuhb5dl 135 5 higher high JJR cord-324859-0yuhb5dl 135 6 neutrophils neutrophil NNS cord-324859-0yuhb5dl 135 7 , , , cord-324859-0yuhb5dl 135 8 high high JJ cord-324859-0yuhb5dl 135 9 CRP crp NN cord-324859-0yuhb5dl 135 10 and and CC cord-324859-0yuhb5dl 135 11 decreased decrease VBD cord-324859-0yuhb5dl 135 12 T T NNP cord-324859-0yuhb5dl 135 13 cell cell NN cord-324859-0yuhb5dl 135 14 found find VBN cord-324859-0yuhb5dl 135 15 in in IN cord-324859-0yuhb5dl 135 16 severe severe JJ cord-324859-0yuhb5dl 135 17 cases case NNS cord-324859-0yuhb5dl 135 18 ; ; : cord-324859-0yuhb5dl 135 19 IL-10 IL-10 NNP cord-324859-0yuhb5dl 135 20 level level NN cord-324859-0yuhb5dl 135 21 was be VBD cord-324859-0yuhb5dl 135 22 significantly significantly RB cord-324859-0yuhb5dl 135 23 varied varied JJ cord-324859-0yuhb5dl 135 24 with with IN cord-324859-0yuhb5dl 135 25 disease disease NN cord-324859-0yuhb5dl 135 26 progression progression NN cord-324859-0yuhb5dl 135 27 and and CC cord-324859-0yuhb5dl 135 28 treatment treatment NN cord-324859-0yuhb5dl 135 29 . . . cord-324859-0yuhb5dl 136 1 52 52 CD cord-324859-0yuhb5dl 136 2 37.5 37.5 CD cord-324859-0yuhb5dl 136 3 % % NN cord-324859-0yuhb5dl 136 4 M M NNP cord-324859-0yuhb5dl 136 5 35 35 CD cord-324859-0yuhb5dl 136 6 % % NN cord-324859-0yuhb5dl 136 7 13 13 CD cord-324859-0yuhb5dl 136 8 27 27 CD cord-324859-0yuhb5dl 136 9 Severe severe JJ cord-324859-0yuhb5dl 136 10 cases case NNS cord-324859-0yuhb5dl 136 11 showed show VBD cord-324859-0yuhb5dl 136 12 significant significant JJ cord-324859-0yuhb5dl 136 13 and and CC cord-324859-0yuhb5dl 136 14 sustained sustained JJ cord-324859-0yuhb5dl 136 15 decreases decrease NNS cord-324859-0yuhb5dl 136 16 in in IN cord-324859-0yuhb5dl 136 17 lymphocyte lymphocyte NN cord-324859-0yuhb5dl 136 18 counts count NNS cord-324859-0yuhb5dl 136 19 , , , cord-324859-0yuhb5dl 136 20 CD8 CD8 NNP cord-324859-0yuhb5dl 136 21 cells cell NNS cord-324859-0yuhb5dl 136 22 , , , cord-324859-0yuhb5dl 136 23 increase increase VBP cord-324859-0yuhb5dl 136 24 in in IN cord-324859-0yuhb5dl 136 25 IL-6 IL-6 NNP cord-324859-0yuhb5dl 136 26 , , , cord-324859-0yuhb5dl 136 27 IL-10 IL-10 NNP cord-324859-0yuhb5dl 136 28 , , , cord-324859-0yuhb5dl 136 29 IL-2 IL-2 NNP cord-324859-0yuhb5dl 136 30 and and CC cord-324859-0yuhb5dl 136 31 IFN IFN NNP cord-324859-0yuhb5dl 136 32 - - HYPH cord-324859-0yuhb5dl 136 33 γ γ NN cord-324859-0yuhb5dl 136 34 levels level NNS cord-324859-0yuhb5dl 136 35 compared compare VBN cord-324859-0yuhb5dl 136 36 to to IN cord-324859-0yuhb5dl 136 37 mild mild JJ cord-324859-0yuhb5dl 136 38 cases case NNS cord-324859-0yuhb5dl 136 39 . . . cord-324859-0yuhb5dl 137 1 The the DT cord-324859-0yuhb5dl 137 2 degree degree NN cord-324859-0yuhb5dl 137 3 of of IN cord-324859-0yuhb5dl 137 4 lymphopenia lymphopenia NNP cord-324859-0yuhb5dl 137 5 and and CC cord-324859-0yuhb5dl 137 6 a a DT cord-324859-0yuhb5dl 137 7 pro pro JJ cord-324859-0yuhb5dl 137 8 - - JJ cord-324859-0yuhb5dl 137 9 inflammatory inflammatory JJ cord-324859-0yuhb5dl 137 10 cytokine cytokine NN cord-324859-0yuhb5dl 137 11 storm storm NN cord-324859-0yuhb5dl 137 12 is be VBZ cord-324859-0yuhb5dl 137 13 higher high JJR cord-324859-0yuhb5dl 137 14 in in IN cord-324859-0yuhb5dl 137 15 severe severe JJ cord-324859-0yuhb5dl 137 16 COVID-19 covid-19 JJ cord-324859-0yuhb5dl 137 17 patients patient NNS cord-324859-0yuhb5dl 137 18 than than IN cord-324859-0yuhb5dl 137 19 in in IN cord-324859-0yuhb5dl 137 20 mild mild JJ cord-324859-0yuhb5dl 137 21 cases case NNS cord-324859-0yuhb5dl 137 22 and and CC cord-324859-0yuhb5dl 137 23 is be VBZ cord-324859-0yuhb5dl 137 24 associated associate VBN cord-324859-0yuhb5dl 137 25 with with IN cord-324859-0yuhb5dl 137 26 the the DT cord-324859-0yuhb5dl 137 27 disease disease NN cord-324859-0yuhb5dl 137 28 severity severity NN cord-324859-0yuhb5dl 137 29 . . . cord-324859-0yuhb5dl 138 1 53 53 CD cord-324859-0yuhb5dl 138 2 64.4 64.4 CD cord-324859-0yuhb5dl 138 3 % % NN cord-324859-0yuhb5dl 138 4 M M NNP cord-324859-0yuhb5dl 138 5 34.20 34.20 CD cord-324859-0yuhb5dl 138 6 % % NN cord-324859-0yuhb5dl 138 7 30 30 CD cord-324859-0yuhb5dl 138 8 46 46 CD cord-324859-0yuhb5dl 139 1 The the DT cord-324859-0yuhb5dl 139 2 CD4 CD4 NNP cord-324859-0yuhb5dl 139 3 + + CC cord-324859-0yuhb5dl 139 4 T T NNP cord-324859-0yuhb5dl 139 5 and and CC cord-324859-0yuhb5dl 139 6 CD8 CD8 NNP cord-324859-0yuhb5dl 139 7 + + CC cord-324859-0yuhb5dl 139 8 T t NN cord-324859-0yuhb5dl 139 9 - - HYPH cord-324859-0yuhb5dl 139 10 lymphocyte lymphocyte NN cord-324859-0yuhb5dl 139 11 counts count NNS cord-324859-0yuhb5dl 139 12 differed differ VBD cord-324859-0yuhb5dl 139 13 significantly significantly RB cord-324859-0yuhb5dl 139 14 between between IN cord-324859-0yuhb5dl 139 15 the the DT cord-324859-0yuhb5dl 139 16 two two CD cord-324859-0yuhb5dl 139 17 groups group NNS cord-324859-0yuhb5dl 139 18 , , , cord-324859-0yuhb5dl 139 19 as as IN cord-324859-0yuhb5dl 139 20 did do VBD cord-324859-0yuhb5dl 139 21 differences difference NNS cord-324859-0yuhb5dl 139 22 in in IN cord-324859-0yuhb5dl 139 23 interleukin interleukin NN cord-324859-0yuhb5dl 139 24 IL-2R IL-2R NNP cord-324859-0yuhb5dl 139 25 , , , cord-324859-0yuhb5dl 139 26 IL-6 IL-6 NNP cord-324859-0yuhb5dl 139 27 and and CC cord-324859-0yuhb5dl 139 28 IL-8 IL-8 NNP cord-324859-0yuhb5dl 139 29 levels level NNS cord-324859-0yuhb5dl 139 30 . . . cord-324859-0yuhb5dl 140 1 SARS SARS NNP cord-324859-0yuhb5dl 140 2 - - HYPH cord-324859-0yuhb5dl 140 3 CoV-2 CoV-2 NNP cord-324859-0yuhb5dl 140 4 RNA RNA NNP cord-324859-0yuhb5dl 140 5 load load NN cord-324859-0yuhb5dl 140 6 and and CC cord-324859-0yuhb5dl 140 7 lymphocyte lymphocyte NN cord-324859-0yuhb5dl 140 8 count count NN cord-324859-0yuhb5dl 140 9 , , , cord-324859-0yuhb5dl 140 10 CD4 CD4 NNP cord-324859-0yuhb5dl 140 11 + + CC cord-324859-0yuhb5dl 140 12 T t NN cord-324859-0yuhb5dl 140 13 - - HYPH cord-324859-0yuhb5dl 140 14 lymphocyte lymphocyte NN cord-324859-0yuhb5dl 140 15 count count NN cord-324859-0yuhb5dl 140 16 and and CC cord-324859-0yuhb5dl 140 17 CD8 CD8 NNP cord-324859-0yuhb5dl 140 18 + + CC cord-324859-0yuhb5dl 140 19 T t NN cord-324859-0yuhb5dl 140 20 - - HYPH cord-324859-0yuhb5dl 140 21 lymphocyte lymphocyte NN cord-324859-0yuhb5dl 140 22 count count NN cord-324859-0yuhb5dl 140 23 were be VBD cord-324859-0yuhb5dl 140 24 linearly linearly RB cord-324859-0yuhb5dl 140 25 negatively negatively RB cord-324859-0yuhb5dl 140 26 correlated correlate VBN cord-324859-0yuhb5dl 140 27 . . . cord-324859-0yuhb5dl 141 1 54 54 CD cord-324859-0yuhb5dl 141 2 35 35 CD cord-324859-0yuhb5dl 141 3 % % NN cord-324859-0yuhb5dl 141 4 M M NNP cord-324859-0yuhb5dl 141 5 24 24 CD cord-324859-0yuhb5dl 141 6 % % NN cord-324859-0yuhb5dl 141 7 diabetes diabete NNS cord-324859-0yuhb5dl 141 8 , , , cord-324859-0yuhb5dl 141 9 25 25 CD cord-324859-0yuhb5dl 141 10 % % NN cord-324859-0yuhb5dl 141 11 cardiopathy cardiopathy NN cord-324859-0yuhb5dl 141 12 and and CC cord-324859-0yuhb5dl 141 13 45 45 CD cord-324859-0yuhb5dl 141 14 % % NN cord-324859-0yuhb5dl 141 15 hypertension hypertension NN cord-324859-0yuhb5dl 141 16 33 33 CD cord-324859-0yuhb5dl 141 17 107 107 CD cord-324859-0yuhb5dl 142 1 The the DT cord-324859-0yuhb5dl 142 2 proportion proportion NN cord-324859-0yuhb5dl 142 3 of of IN cord-324859-0yuhb5dl 142 4 patients patient NNS cord-324859-0yuhb5dl 142 5 with with IN cord-324859-0yuhb5dl 142 6 increased increase VBN cord-324859-0yuhb5dl 142 7 IL-6 IL-6 NNP cord-324859-0yuhb5dl 142 8 and and CC cord-324859-0yuhb5dl 142 9 CRP CRP NNP cord-324859-0yuhb5dl 142 10 levels level NNS cord-324859-0yuhb5dl 142 11 was be VBD cord-324859-0yuhb5dl 142 12 significantly significantly RB cord-324859-0yuhb5dl 142 13 higher high JJR cord-324859-0yuhb5dl 142 14 in in IN cord-324859-0yuhb5dl 142 15 the the DT cord-324859-0yuhb5dl 142 16 severe severe JJ cord-324859-0yuhb5dl 142 17 group group NN cord-324859-0yuhb5dl 142 18 compared compare VBN cord-324859-0yuhb5dl 142 19 to to IN cord-324859-0yuhb5dl 142 20 mild mild JJ cord-324859-0yuhb5dl 142 21 group group NN cord-324859-0yuhb5dl 142 22 . . . cord-324859-0yuhb5dl 143 1 Cox Cox NNP cord-324859-0yuhb5dl 143 2 proportional proportional JJ cord-324859-0yuhb5dl 143 3 hazard hazard NN cord-324859-0yuhb5dl 143 4 model model NN cord-324859-0yuhb5dl 143 5 showed show VBD cord-324859-0yuhb5dl 143 6 that that IN cord-324859-0yuhb5dl 143 7 IL-6 IL-6 NNP cord-324859-0yuhb5dl 143 8 and and CC cord-324859-0yuhb5dl 143 9 CRP CRP NNP cord-324859-0yuhb5dl 143 10 could could MD cord-324859-0yuhb5dl 143 11 be be VB cord-324859-0yuhb5dl 143 12 used use VBN cord-324859-0yuhb5dl 143 13 as as IN cord-324859-0yuhb5dl 143 14 independent independent JJ cord-324859-0yuhb5dl 143 15 factors factor NNS cord-324859-0yuhb5dl 143 16 to to TO cord-324859-0yuhb5dl 143 17 predict predict VB cord-324859-0yuhb5dl 143 18 the the DT cord-324859-0yuhb5dl 143 19 severity severity NN cord-324859-0yuhb5dl 143 20 of of IN cord-324859-0yuhb5dl 143 21 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 143 22 . . . cord-324859-0yuhb5dl 143 23 64 64 CD cord-324859-0yuhb5dl 143 24 63 63 CD cord-324859-0yuhb5dl 143 25 % % NN cord-324859-0yuhb5dl 143 26 M M NNP cord-324859-0yuhb5dl 143 27 55.50 55.50 CD cord-324859-0yuhb5dl 143 28 % % NN cord-324859-0yuhb5dl 143 29 31 31 CD cord-324859-0yuhb5dl 143 30 23 23 CD cord-324859-0yuhb5dl 143 31 Lymphocytes lymphocyte NNS cord-324859-0yuhb5dl 143 32 lower low JJR cord-324859-0yuhb5dl 143 33 , , , cord-324859-0yuhb5dl 143 34 IL-2R IL-2R NNP cord-324859-0yuhb5dl 143 35 and and CC cord-324859-0yuhb5dl 143 36 IL-6 IL-6 NNP cord-324859-0yuhb5dl 143 37 higher high JJR cord-324859-0yuhb5dl 143 38 , , , cord-324859-0yuhb5dl 143 39 and and CC cord-324859-0yuhb5dl 143 40 prolonged prolong VBN cord-324859-0yuhb5dl 143 41 PT pt NN cord-324859-0yuhb5dl 143 42 in in IN cord-324859-0yuhb5dl 143 43 more more RBR cord-324859-0yuhb5dl 143 44 critical critical JJ cord-324859-0yuhb5dl 143 45 patients patient NNS cord-324859-0yuhb5dl 143 46 . . . cord-324859-0yuhb5dl 144 1 55 55 CD cord-324859-0yuhb5dl 144 2 55 55 CD cord-324859-0yuhb5dl 144 3 % % NN cord-324859-0yuhb5dl 144 4 M M NNP cord-324859-0yuhb5dl 144 5 50.80 50.80 CD cord-324859-0yuhb5dl 144 6 % % NN cord-324859-0yuhb5dl 144 7 28 28 CD cord-324859-0yuhb5dl 144 8 died die VBD cord-324859-0yuhb5dl 144 9 , , , cord-324859-0yuhb5dl 144 10 42 42 CD cord-324859-0yuhb5dl 144 11 in in IN cord-324859-0yuhb5dl 144 12 - - HYPH cord-324859-0yuhb5dl 144 13 hospital hospital NN cord-324859-0yuhb5dl 144 14 and and CC cord-324859-0yuhb5dl 144 15 117 117 CD cord-324859-0yuhb5dl 144 16 discharged discharge VBN cord-324859-0yuhb5dl 145 1 All all DT cord-324859-0yuhb5dl 145 2 patients patient NNS cord-324859-0yuhb5dl 145 3 exhibited exhibit VBD cord-324859-0yuhb5dl 145 4 a a DT cord-324859-0yuhb5dl 145 5 significant significant JJ cord-324859-0yuhb5dl 145 6 drop drop NN cord-324859-0yuhb5dl 145 7 of of IN cord-324859-0yuhb5dl 145 8 T t NN cord-324859-0yuhb5dl 145 9 - - HYPH cord-324859-0yuhb5dl 145 10 lymphocyte lymphocyte NN cord-324859-0yuhb5dl 145 11 subset subset NN cord-324859-0yuhb5dl 145 12 counts count VBZ cord-324859-0yuhb5dl 145 13 with with IN cord-324859-0yuhb5dl 145 14 remarkably remarkably RB cord-324859-0yuhb5dl 145 15 increasing increase VBG cord-324859-0yuhb5dl 145 16 concentrations concentration NNS cord-324859-0yuhb5dl 145 17 of of IN cord-324859-0yuhb5dl 145 18 CRP CRP NNP cord-324859-0yuhb5dl 145 19 , , , cord-324859-0yuhb5dl 145 20 IL-6 IL-6 NNP cord-324859-0yuhb5dl 145 21 and and CC cord-324859-0yuhb5dl 145 22 IL-10 IL-10 NNP cord-324859-0yuhb5dl 145 23 compared compare VBD cord-324859-0yuhb5dl 145 24 to to IN cord-324859-0yuhb5dl 145 25 normal normal JJ cord-324859-0yuhb5dl 145 26 values value NNS cord-324859-0yuhb5dl 145 27 . . . cord-324859-0yuhb5dl 146 1 The the DT cord-324859-0yuhb5dl 146 2 median median JJ cord-324859-0yuhb5dl 146 3 lymphocyte lymphocyte NN cord-324859-0yuhb5dl 146 4 , , , cord-324859-0yuhb5dl 146 5 CD3 CD3 NNP cord-324859-0yuhb5dl 146 6 + + CC cord-324859-0yuhb5dl 146 7 T T NNP cord-324859-0yuhb5dl 146 8 cell cell NN cord-324859-0yuhb5dl 146 9 , , , cord-324859-0yuhb5dl 146 10 CD4 CD4 NNP cord-324859-0yuhb5dl 146 11 + + CC cord-324859-0yuhb5dl 146 12 T T NNP cord-324859-0yuhb5dl 146 13 cell cell NN cord-324859-0yuhb5dl 146 14 , , , cord-324859-0yuhb5dl 146 15 CD8 CD8 NNP cord-324859-0yuhb5dl 146 16 + + CC cord-324859-0yuhb5dl 146 17 T T NNP cord-324859-0yuhb5dl 146 18 cell cell NN cord-324859-0yuhb5dl 146 19 and and CC cord-324859-0yuhb5dl 146 20 B b NN cord-324859-0yuhb5dl 146 21 cell cell NN cord-324859-0yuhb5dl 146 22 were be VBD cord-324859-0yuhb5dl 146 23 significantly significantly RB cord-324859-0yuhb5dl 146 24 lower low JJR cord-324859-0yuhb5dl 146 25 in in IN cord-324859-0yuhb5dl 146 26 patients patient NNS cord-324859-0yuhb5dl 146 27 who who WP cord-324859-0yuhb5dl 146 28 died die VBD cord-324859-0yuhb5dl 146 29 . . . cord-324859-0yuhb5dl 147 1 Lower low JJR cord-324859-0yuhb5dl 147 2 counts count NNS cord-324859-0yuhb5dl 147 3 ( ( -LRB- cord-324859-0yuhb5dl 147 4 /uL /uL NFP cord-324859-0yuhb5dl 147 5 ) ) -RRB- cord-324859-0yuhb5dl 147 6 of of IN cord-324859-0yuhb5dl 147 7 T t NN cord-324859-0yuhb5dl 147 8 - - HYPH cord-324859-0yuhb5dl 147 9 lymphocyte lymphocyte NN cord-324859-0yuhb5dl 147 10 subsets subset NNS cord-324859-0yuhb5dl 147 11 were be VBD cord-324859-0yuhb5dl 147 12 associated associate VBN cord-324859-0yuhb5dl 147 13 with with IN cord-324859-0yuhb5dl 147 14 higher high JJR cord-324859-0yuhb5dl 147 15 risks risk NNS cord-324859-0yuhb5dl 147 16 of of IN cord-324859-0yuhb5dl 147 17 in in IN cord-324859-0yuhb5dl 147 18 - - HYPH cord-324859-0yuhb5dl 147 19 hospital hospital NN cord-324859-0yuhb5dl 147 20 death death NN cord-324859-0yuhb5dl 147 21 . . . cord-324859-0yuhb5dl 148 1 54 54 CD cord-324859-0yuhb5dl 148 2 43.6 43.6 CD cord-324859-0yuhb5dl 148 3 % % NN cord-324859-0yuhb5dl 148 4 M M NNP cord-324859-0yuhb5dl 148 5 Not not RB cord-324859-0yuhb5dl 148 6 given give VBN cord-324859-0yuhb5dl 148 7 21 21 CD cord-324859-0yuhb5dl 148 8 34 34 CD cord-324859-0yuhb5dl 148 9 Patients patient NNS cord-324859-0yuhb5dl 148 10 in in IN cord-324859-0yuhb5dl 148 11 the the DT cord-324859-0yuhb5dl 148 12 severe severe JJ cord-324859-0yuhb5dl 148 13 group group NN cord-324859-0yuhb5dl 148 14 had have VBD cord-324859-0yuhb5dl 148 15 a a DT cord-324859-0yuhb5dl 148 16 lower low JJR cord-324859-0yuhb5dl 148 17 lymphocyte lymphocyte NN cord-324859-0yuhb5dl 148 18 count count NN cord-324859-0yuhb5dl 148 19 and and CC cord-324859-0yuhb5dl 148 20 CD3-T CD3-T NNP cord-324859-0yuhb5dl 148 21 cells cell NNS cord-324859-0yuhb5dl 148 22 percentage percentage NN cord-324859-0yuhb5dl 148 23 than than IN cord-324859-0yuhb5dl 148 24 the the DT cord-324859-0yuhb5dl 148 25 nonsevere nonsevere JJ cord-324859-0yuhb5dl 148 26 group group NN cord-324859-0yuhb5dl 148 27 . . . cord-324859-0yuhb5dl 149 1 The the DT cord-324859-0yuhb5dl 149 2 severe severe JJ cord-324859-0yuhb5dl 149 3 group group NN cord-324859-0yuhb5dl 149 4 also also RB cord-324859-0yuhb5dl 149 5 had have VBD cord-324859-0yuhb5dl 149 6 a a DT cord-324859-0yuhb5dl 149 7 higher high JJR cord-324859-0yuhb5dl 149 8 interleukin-6 interleukin-6 NNP cord-324859-0yuhb5dl 149 9 level level NN cord-324859-0yuhb5dl 149 10 than than IN cord-324859-0yuhb5dl 149 11 the the DT cord-324859-0yuhb5dl 149 12 nonsevere nonsevere JJ cord-324859-0yuhb5dl 149 13 group group NN cord-324859-0yuhb5dl 149 14 . . . cord-324859-0yuhb5dl 150 1 57 57 CD cord-324859-0yuhb5dl 150 2 Not not RB cord-324859-0yuhb5dl 150 3 given give VBN cord-324859-0yuhb5dl 150 4 37.50 37.50 CD cord-324859-0yuhb5dl 150 5 % % NN cord-324859-0yuhb5dl 150 6 6 6 CD cord-324859-0yuhb5dl 150 7 10 10 CD cord-324859-0yuhb5dl 150 8 Among among IN cord-324859-0yuhb5dl 150 9 the the DT cord-324859-0yuhb5dl 150 10 differentially differentially RB cord-324859-0yuhb5dl 150 11 expressed express VBN cord-324859-0yuhb5dl 150 12 functional functional JJ cord-324859-0yuhb5dl 150 13 molecules molecule NNS cord-324859-0yuhb5dl 150 14 , , , cord-324859-0yuhb5dl 150 15 the the DT cord-324859-0yuhb5dl 150 16 levels level NNS cord-324859-0yuhb5dl 150 17 of of IN cord-324859-0yuhb5dl 150 18 interferon interferon NN cord-324859-0yuhb5dl 150 19 - - HYPH cord-324859-0yuhb5dl 150 20 γ γ NN cord-324859-0yuhb5dl 150 21 and and CC cord-324859-0yuhb5dl 150 22 TNF TNF NNP cord-324859-0yuhb5dl 150 23 - - HYPH cord-324859-0yuhb5dl 150 24 α α NNP cord-324859-0yuhb5dl 150 25 in in IN cord-324859-0yuhb5dl 150 26 CD4 CD4 NNP cord-324859-0yuhb5dl 150 27 + + CC cord-324859-0yuhb5dl 150 28 T t NN cord-324859-0yuhb5dl 150 29 cells cell NNS cord-324859-0yuhb5dl 150 30 were be VBD cord-324859-0yuhb5dl 150 31 lower low JJR cord-324859-0yuhb5dl 150 32 in in IN cord-324859-0yuhb5dl 150 33 the the DT cord-324859-0yuhb5dl 150 34 severe severe JJ cord-324859-0yuhb5dl 150 35 group group NN cord-324859-0yuhb5dl 150 36 than than IN cord-324859-0yuhb5dl 150 37 in in IN cord-324859-0yuhb5dl 150 38 the the DT cord-324859-0yuhb5dl 150 39 mild mild JJ cord-324859-0yuhb5dl 150 40 group group NN cord-324859-0yuhb5dl 150 41 , , , cord-324859-0yuhb5dl 150 42 whereas whereas IN cord-324859-0yuhb5dl 150 43 the the DT cord-324859-0yuhb5dl 150 44 levels level NNS cord-324859-0yuhb5dl 150 45 of of IN cord-324859-0yuhb5dl 150 46 granzyme granzyme NNS cord-324859-0yuhb5dl 150 47 B b NN cord-324859-0yuhb5dl 150 48 and and CC cord-324859-0yuhb5dl 150 49 perforin perforin NNP cord-324859-0yuhb5dl 150 50 in in IN cord-324859-0yuhb5dl 150 51 CD8 CD8 NNP cord-324859-0yuhb5dl 150 52 + + CC cord-324859-0yuhb5dl 150 53 T T NNP cord-324859-0yuhb5dl 150 54 cells cell NNS cord-324859-0yuhb5dl 150 55 were be VBD cord-324859-0yuhb5dl 150 56 higher high JJR cord-324859-0yuhb5dl 150 57 in in IN cord-324859-0yuhb5dl 150 58 the the DT cord-324859-0yuhb5dl 150 59 severe severe JJ cord-324859-0yuhb5dl 150 60 group group NN cord-324859-0yuhb5dl 150 61 . . . cord-324859-0yuhb5dl 151 1 58 58 CD cord-324859-0yuhb5dl 151 2 53 53 CD cord-324859-0yuhb5dl 151 3 % % NN cord-324859-0yuhb5dl 151 4 M m NN cord-324859-0yuhb5dl 151 5 Not not RB cord-324859-0yuhb5dl 151 6 given give VBN cord-324859-0yuhb5dl 151 7 13 13 CD cord-324859-0yuhb5dl 151 8 55 55 CD cord-324859-0yuhb5dl 152 1 The the DT cord-324859-0yuhb5dl 152 2 number number NN cord-324859-0yuhb5dl 152 3 of of IN cord-324859-0yuhb5dl 152 4 T t NN cord-324859-0yuhb5dl 152 5 cells cell NNS cord-324859-0yuhb5dl 152 6 and and CC cord-324859-0yuhb5dl 152 7 CD8 CD8 NNP cord-324859-0yuhb5dl 152 8 + + CC cord-324859-0yuhb5dl 152 9 T T NNP cord-324859-0yuhb5dl 152 10 cells cell NNS cord-324859-0yuhb5dl 152 11 was be VBD cord-324859-0yuhb5dl 152 12 significantly significantly RB cord-324859-0yuhb5dl 152 13 lower low JJR cord-324859-0yuhb5dl 152 14 in in IN cord-324859-0yuhb5dl 152 15 severe severe JJ cord-324859-0yuhb5dl 152 16 patients patient NNS cord-324859-0yuhb5dl 152 17 than than IN cord-324859-0yuhb5dl 152 18 that that DT cord-324859-0yuhb5dl 152 19 in in IN cord-324859-0yuhb5dl 152 20 the the DT cord-324859-0yuhb5dl 152 21 mild mild JJ cord-324859-0yuhb5dl 152 22 cases case NNS cord-324859-0yuhb5dl 152 23 . . . cord-324859-0yuhb5dl 153 1 59 59 CD cord-324859-0yuhb5dl 153 2 CD8 CD8 NNS cord-324859-0yuhb5dl 153 3 + + CC cord-324859-0yuhb5dl 153 4 T T NNP cord-324859-0yuhb5dl 153 5 ) ) -RRB- cord-324859-0yuhb5dl 153 6 in in IN cord-324859-0yuhb5dl 153 7 severely severely RB cord-324859-0yuhb5dl 153 8 diseased diseased JJ cord-324859-0yuhb5dl 153 9 patients patient NNS cord-324859-0yuhb5dl 153 10 , , , cord-324859-0yuhb5dl 153 11 compared compare VBN cord-324859-0yuhb5dl 153 12 to to IN cord-324859-0yuhb5dl 153 13 the the DT cord-324859-0yuhb5dl 153 14 nonsevere nonsevere JJ cord-324859-0yuhb5dl 153 15 ones one NNS cord-324859-0yuhb5dl 153 16 , , , cord-324859-0yuhb5dl 153 17 through through IN cord-324859-0yuhb5dl 153 18 a a DT cord-324859-0yuhb5dl 153 19 meta meta JJ cord-324859-0yuhb5dl 153 20 - - HYPH cord-324859-0yuhb5dl 153 21 analysis analysis NN cord-324859-0yuhb5dl 153 22 . . . cord-324859-0yuhb5dl 154 1 Severity severity NN cord-324859-0yuhb5dl 154 2 was be VBD cord-324859-0yuhb5dl 154 3 defined define VBN cord-324859-0yuhb5dl 154 4 according accord VBG cord-324859-0yuhb5dl 154 5 to to IN cord-324859-0yuhb5dl 154 6 the the DT cord-324859-0yuhb5dl 154 7 WHO WHO NNP cord-324859-0yuhb5dl 154 8 interim interim JJ cord-324859-0yuhb5dl 154 9 guidance guidance NN cord-324859-0yuhb5dl 154 10 or or CC cord-324859-0yuhb5dl 154 11 the the DT cord-324859-0yuhb5dl 154 12 Chinese chinese JJ cord-324859-0yuhb5dl 154 13 protocol protocol NN cord-324859-0yuhb5dl 154 14 in in IN cord-324859-0yuhb5dl 154 15 a a DT cord-324859-0yuhb5dl 154 16 majority majority NN cord-324859-0yuhb5dl 154 17 ( ( -LRB- cord-324859-0yuhb5dl 154 18 78 78 CD cord-324859-0yuhb5dl 154 19 % % NN cord-324859-0yuhb5dl 154 20 ) ) -RRB- cord-324859-0yuhb5dl 154 21 of of IN cord-324859-0yuhb5dl 154 22 the the DT cord-324859-0yuhb5dl 154 23 meta meta NNP cord-324859-0yuhb5dl 154 24 - - HYPH cord-324859-0yuhb5dl 154 25 analysed analyse VBN cord-324859-0yuhb5dl 154 26 studies study NNS cord-324859-0yuhb5dl 154 27 . . . cord-324859-0yuhb5dl 155 1 One one CD cord-324859-0yuhb5dl 155 2 study study NN cord-324859-0yuhb5dl 155 3 defined define VBD cord-324859-0yuhb5dl 155 4 an an DT cord-324859-0yuhb5dl 155 5 oxygen oxygen NN cord-324859-0yuhb5dl 155 6 saturation saturation NN cord-324859-0yuhb5dl 155 7 of of IN cord-324859-0yuhb5dl 155 8 ≤90 ≤90 NNP cord-324859-0yuhb5dl 155 9 % % NN cord-324859-0yuhb5dl 155 10 as as IN cord-324859-0yuhb5dl 155 11 the the DT cord-324859-0yuhb5dl 155 12 severe severe JJ cord-324859-0yuhb5dl 155 13 group group NN cord-324859-0yuhb5dl 155 14 , , , cord-324859-0yuhb5dl 155 15 while while IN cord-324859-0yuhb5dl 155 16 another another DT cord-324859-0yuhb5dl 155 17 used use VBN cord-324859-0yuhb5dl 155 18 categories category NNS cord-324859-0yuhb5dl 155 19 of of IN cord-324859-0yuhb5dl 155 20 dead dead JJ cord-324859-0yuhb5dl 155 21 and and CC cord-324859-0yuhb5dl 155 22 discharged discharge VBN cord-324859-0yuhb5dl 155 23 . . . cord-324859-0yuhb5dl 156 1 For for IN cord-324859-0yuhb5dl 156 2 three three CD cord-324859-0yuhb5dl 156 3 studies study NNS cord-324859-0yuhb5dl 156 4 , , , cord-324859-0yuhb5dl 156 5 categorization categorization NN cord-324859-0yuhb5dl 156 6 into into IN cord-324859-0yuhb5dl 156 7 severe severe JJ cord-324859-0yuhb5dl 156 8 and and CC cord-324859-0yuhb5dl 156 9 non non JJ cord-324859-0yuhb5dl 156 10 - - JJ cord-324859-0yuhb5dl 156 11 severe severe JJ cord-324859-0yuhb5dl 156 12 groups group NNS cord-324859-0yuhb5dl 156 13 was be VBD cord-324859-0yuhb5dl 156 14 not not RB cord-324859-0yuhb5dl 156 15 described describe VBN cord-324859-0yuhb5dl 156 16 . . . cord-324859-0yuhb5dl 157 1 Forest forest NN cord-324859-0yuhb5dl 157 2 plots plot NNS cord-324859-0yuhb5dl 157 3 were be VBD cord-324859-0yuhb5dl 157 4 generated generate VBN cord-324859-0yuhb5dl 157 5 , , , cord-324859-0yuhb5dl 157 6 and and CC cord-324859-0yuhb5dl 157 7 mean mean VB cord-324859-0yuhb5dl 157 8 difference difference NN cord-324859-0yuhb5dl 157 9 was be VBD cord-324859-0yuhb5dl 157 10 calculated calculate VBN cord-324859-0yuhb5dl 157 11 using use VBG cord-324859-0yuhb5dl 157 12 the the DT cord-324859-0yuhb5dl 157 13 random random JJ cord-324859-0yuhb5dl 157 14 - - HYPH cord-324859-0yuhb5dl 157 15 effects effect NNS cord-324859-0yuhb5dl 157 16 model model NN cord-324859-0yuhb5dl 157 17 . . . cord-324859-0yuhb5dl 158 1 Results result NNS cord-324859-0yuhb5dl 158 2 from from IN cord-324859-0yuhb5dl 158 3 the the DT cord-324859-0yuhb5dl 158 4 meta meta NNP cord-324859-0yuhb5dl 158 5 - - HYPH cord-324859-0yuhb5dl 158 6 analysis analysis NN cord-324859-0yuhb5dl 158 7 showed show VBD cord-324859-0yuhb5dl 158 8 significantly significantly RB cord-324859-0yuhb5dl 158 9 higher high JJR cord-324859-0yuhb5dl 158 10 mean mean JJ cord-324859-0yuhb5dl 158 11 levels level NNS cord-324859-0yuhb5dl 158 12 of of IN cord-324859-0yuhb5dl 158 13 IL-6 IL-6 NNP cord-324859-0yuhb5dl 158 14 ( ( -LRB- cord-324859-0yuhb5dl 158 15 21 21 CD cord-324859-0yuhb5dl 158 16 studies study NNS cord-324859-0yuhb5dl 158 17 ( ( -LRB- cord-324859-0yuhb5dl 158 18 n n NN cord-324859-0yuhb5dl 158 19 = = SYM cord-324859-0yuhb5dl 158 20 2477 2477 CD cord-324859-0yuhb5dl 158 21 ) ) -RRB- cord-324859-0yuhb5dl 159 1 ; ; : cord-324859-0yuhb5dl 159 2 mean mean VB cord-324859-0yuhb5dl 159 3 difference difference NN cord-324859-0yuhb5dl 159 4 : : : cord-324859-0yuhb5dl 159 5 19.55 19.55 CD cord-324859-0yuhb5dl 159 6 pg pg NN cord-324859-0yuhb5dl 159 7 / / SYM cord-324859-0yuhb5dl 159 8 mL ml NN cord-324859-0yuhb5dl 159 9 ; ; : cord-324859-0yuhb5dl 159 10 CI CI NNP cord-324859-0yuhb5dl 159 11 : : : cord-324859-0yuhb5dl 159 12 14 14 CD cord-324859-0yuhb5dl 159 13 . . . cord-324859-0yuhb5dl 160 1 However however RB cord-324859-0yuhb5dl 160 2 , , , cord-324859-0yuhb5dl 160 3 there there EX cord-324859-0yuhb5dl 160 4 was be VBD cord-324859-0yuhb5dl 160 5 substantial substantial JJ cord-324859-0yuhb5dl 160 6 heterogeneity heterogeneity NN cord-324859-0yuhb5dl 160 7 across across IN cord-324859-0yuhb5dl 160 8 estimates estimate NNS cord-324859-0yuhb5dl 160 9 of of IN cord-324859-0yuhb5dl 160 10 all all PDT cord-324859-0yuhb5dl 160 11 the the DT cord-324859-0yuhb5dl 160 12 inflammatory inflammatory JJ cord-324859-0yuhb5dl 160 13 cytokine cytokine NN cord-324859-0yuhb5dl 160 14 markers marker NNS cord-324859-0yuhb5dl 160 15 ( ( -LRB- cord-324859-0yuhb5dl 160 16 I i NN cord-324859-0yuhb5dl 160 17 2 2 CD cord-324859-0yuhb5dl 160 18 values value NNS cord-324859-0yuhb5dl 160 19 ranging range VBG cord-324859-0yuhb5dl 160 20 from from IN cord-324859-0yuhb5dl 160 21 92 92 CD cord-324859-0yuhb5dl 160 22 % % NN cord-324859-0yuhb5dl 160 23 to to IN cord-324859-0yuhb5dl 160 24 97 97 CD cord-324859-0yuhb5dl 160 25 % % NN cord-324859-0yuhb5dl 160 26 ; ; : cord-324859-0yuhb5dl 160 27 P p NN cord-324859-0yuhb5dl 160 28 - - HYPH cord-324859-0yuhb5dl 160 29 value value NN cord-324859-0yuhb5dl 160 30 < < XX cord-324859-0yuhb5dl 160 31 .05 .05 XX cord-324859-0yuhb5dl 160 32 ; ; : cord-324859-0yuhb5dl 160 33 Table table NN cord-324859-0yuhb5dl 160 34 2 2 CD cord-324859-0yuhb5dl 160 35 ) ) -RRB- cord-324859-0yuhb5dl 160 36 . . . cord-324859-0yuhb5dl 161 1 A a DT cord-324859-0yuhb5dl 161 2 sensitivity sensitivity NN cord-324859-0yuhb5dl 161 3 analysis analysis NN cord-324859-0yuhb5dl 161 4 was be VBD cord-324859-0yuhb5dl 161 5 undertaken undertake VBN cord-324859-0yuhb5dl 161 6 to to TO cord-324859-0yuhb5dl 161 7 obtain obtain VB cord-324859-0yuhb5dl 161 8 pooled pool VBN cord-324859-0yuhb5dl 161 9 estimates estimate NNS cord-324859-0yuhb5dl 161 10 for for IN cord-324859-0yuhb5dl 161 11 each each DT cord-324859-0yuhb5dl 161 12 outcome outcome NN cord-324859-0yuhb5dl 161 13 after after IN cord-324859-0yuhb5dl 161 14 excluding exclude VBG cord-324859-0yuhb5dl 161 15 preprint preprint NN cord-324859-0yuhb5dl 161 16 articles article NNS cord-324859-0yuhb5dl 161 17 . . . cord-324859-0yuhb5dl 162 1 The the DT cord-324859-0yuhb5dl 162 2 results result NNS cord-324859-0yuhb5dl 162 3 from from IN cord-324859-0yuhb5dl 162 4 this this DT cord-324859-0yuhb5dl 162 5 group group NN cord-324859-0yuhb5dl 162 6 of of IN cord-324859-0yuhb5dl 162 7 peer peer NN cord-324859-0yuhb5dl 162 8 - - HYPH cord-324859-0yuhb5dl 162 9 reviewed review VBN cord-324859-0yuhb5dl 162 10 studies study NNS cord-324859-0yuhb5dl 162 11 were be VBD cord-324859-0yuhb5dl 162 12 consistent consistent JJ cord-324859-0yuhb5dl 162 13 with with IN cord-324859-0yuhb5dl 162 14 the the DT cord-324859-0yuhb5dl 162 15 overall overall JJ cord-324859-0yuhb5dl 162 16 analyses analysis NNS cord-324859-0yuhb5dl 162 17 . . . cord-324859-0yuhb5dl 163 1 The the DT cord-324859-0yuhb5dl 163 2 level level NN cord-324859-0yuhb5dl 163 3 of of IN cord-324859-0yuhb5dl 163 4 heterogeneity heterogeneity NN cord-324859-0yuhb5dl 163 5 in in IN cord-324859-0yuhb5dl 163 6 these these DT cord-324859-0yuhb5dl 163 7 two two CD cord-324859-0yuhb5dl 163 8 groups group NNS cord-324859-0yuhb5dl 163 9 was be VBD cord-324859-0yuhb5dl 163 10 also also RB cord-324859-0yuhb5dl 163 11 comparable comparable JJ cord-324859-0yuhb5dl 163 12 . . . cord-324859-0yuhb5dl 164 1 The the DT cord-324859-0yuhb5dl 164 2 forest forest NN cord-324859-0yuhb5dl 164 3 plots plot NNS cord-324859-0yuhb5dl 164 4 for for IN cord-324859-0yuhb5dl 164 5 each each DT cord-324859-0yuhb5dl 164 6 of of IN cord-324859-0yuhb5dl 164 7 the the DT cord-324859-0yuhb5dl 164 8 individual individual JJ cord-324859-0yuhb5dl 164 9 outcomes outcome NNS cord-324859-0yuhb5dl 164 10 included include VBN cord-324859-0yuhb5dl 164 11 in in IN cord-324859-0yuhb5dl 164 12 the the DT cord-324859-0yuhb5dl 164 13 meta meta NNP cord-324859-0yuhb5dl 164 14 - - HYPH cord-324859-0yuhb5dl 164 15 analysis analysis NN cord-324859-0yuhb5dl 164 16 are be VBP cord-324859-0yuhb5dl 164 17 depicted depict VBN cord-324859-0yuhb5dl 164 18 in in IN cord-324859-0yuhb5dl 164 19 Figures figure NNS cord-324859-0yuhb5dl 164 20 2 2 CD cord-324859-0yuhb5dl 164 21 - - SYM cord-324859-0yuhb5dl 164 22 8 8 CD cord-324859-0yuhb5dl 164 23 . . . cord-324859-0yuhb5dl 165 1 Every every DT cord-324859-0yuhb5dl 165 2 plot plot NN cord-324859-0yuhb5dl 165 3 depicts depict VBZ cord-324859-0yuhb5dl 165 4 the the DT cord-324859-0yuhb5dl 165 5 mean mean JJ cord-324859-0yuhb5dl 165 6 values value NNS cord-324859-0yuhb5dl 165 7 of of IN cord-324859-0yuhb5dl 165 8 the the DT cord-324859-0yuhb5dl 165 9 biomarker biomarker NN cord-324859-0yuhb5dl 165 10 in in IN cord-324859-0yuhb5dl 165 11 the the DT cord-324859-0yuhb5dl 165 12 severe severe JJ cord-324859-0yuhb5dl 165 13 and and CC cord-324859-0yuhb5dl 165 14 moderate moderate JJ cord-324859-0yuhb5dl 165 15 groups group NNS cord-324859-0yuhb5dl 165 16 as as RB cord-324859-0yuhb5dl 165 17 well well RB cord-324859-0yuhb5dl 165 18 as as IN cord-324859-0yuhb5dl 165 19 the the DT cord-324859-0yuhb5dl 165 20 mean mean JJ cord-324859-0yuhb5dl 165 21 difference difference NN cord-324859-0yuhb5dl 165 22 in in IN cord-324859-0yuhb5dl 165 23 each each DT cord-324859-0yuhb5dl 165 24 study study NN cord-324859-0yuhb5dl 165 25 , , , cord-324859-0yuhb5dl 165 26 along along IN cord-324859-0yuhb5dl 165 27 with with IN cord-324859-0yuhb5dl 165 28 the the DT cord-324859-0yuhb5dl 165 29 sample sample NN cord-324859-0yuhb5dl 165 30 sizes size NNS cord-324859-0yuhb5dl 165 31 ( ( -LRB- cord-324859-0yuhb5dl 165 32 study study NN cord-324859-0yuhb5dl 165 33 - - HYPH cord-324859-0yuhb5dl 165 34 wise wise JJ cord-324859-0yuhb5dl 165 35 and and CC cord-324859-0yuhb5dl 165 36 cumulative cumulative JJ cord-324859-0yuhb5dl 165 37 ) ) -RRB- cord-324859-0yuhb5dl 165 38 , , , cord-324859-0yuhb5dl 165 39 the the DT cord-324859-0yuhb5dl 165 40 pooled pool VBN cord-324859-0yuhb5dl 165 41 mean mean JJ cord-324859-0yuhb5dl 165 42 difference difference NN cord-324859-0yuhb5dl 165 43 and and CC cord-324859-0yuhb5dl 165 44 the the DT cord-324859-0yuhb5dl 165 45 corresponding correspond VBG cord-324859-0yuhb5dl 165 46 confidence confidence NN cord-324859-0yuhb5dl 165 47 intervals interval NNS cord-324859-0yuhb5dl 165 48 . . . cord-324859-0yuhb5dl 166 1 Funnel funnel NN cord-324859-0yuhb5dl 166 2 plots plot NNS cord-324859-0yuhb5dl 166 3 were be VBD cord-324859-0yuhb5dl 166 4 created create VBN cord-324859-0yuhb5dl 166 5 using use VBG cord-324859-0yuhb5dl 166 6 RevMan RevMan NNP cord-324859-0yuhb5dl 166 7 , , , cord-324859-0yuhb5dl 166 8 for for IN cord-324859-0yuhb5dl 166 9 a a DT cord-324859-0yuhb5dl 166 10 visual visual JJ cord-324859-0yuhb5dl 166 11 assessment assessment NN cord-324859-0yuhb5dl 166 12 of of IN cord-324859-0yuhb5dl 166 13 the the DT cord-324859-0yuhb5dl 166 14 presence presence NN cord-324859-0yuhb5dl 166 15 of of IN cord-324859-0yuhb5dl 166 16 a a DT cord-324859-0yuhb5dl 166 17 possible possible JJ cord-324859-0yuhb5dl 166 18 publication publication NN cord-324859-0yuhb5dl 166 19 bias bias NN cord-324859-0yuhb5dl 166 20 among among IN cord-324859-0yuhb5dl 166 21 studies study NNS cord-324859-0yuhb5dl 166 22 of of IN cord-324859-0yuhb5dl 166 23 each each DT cord-324859-0yuhb5dl 166 24 outcome outcome NN cord-324859-0yuhb5dl 166 25 ( ( -LRB- cord-324859-0yuhb5dl 166 26 File File NNP cord-324859-0yuhb5dl 166 27 S1 S1 NNP cord-324859-0yuhb5dl 166 28 ) ) -RRB- cord-324859-0yuhb5dl 166 29 . . . cord-324859-0yuhb5dl 167 1 A a DT cord-324859-0yuhb5dl 167 2 few few JJ cord-324859-0yuhb5dl 167 3 plots plot NNS cord-324859-0yuhb5dl 167 4 demonstrated demonstrate VBD cord-324859-0yuhb5dl 167 5 some some DT cord-324859-0yuhb5dl 167 6 asymmetry asymmetry NN cord-324859-0yuhb5dl 167 7 which which WDT cord-324859-0yuhb5dl 167 8 was be VBD cord-324859-0yuhb5dl 167 9 further further RB cord-324859-0yuhb5dl 167 10 statistically statistically RB cord-324859-0yuhb5dl 167 11 assessed assess VBN cord-324859-0yuhb5dl 167 12 using use VBG cord-324859-0yuhb5dl 167 13 Egger Egger NNP cord-324859-0yuhb5dl 167 14 's 's POS cord-324859-0yuhb5dl 167 15 test test NN cord-324859-0yuhb5dl 167 16 in in IN cord-324859-0yuhb5dl 167 17 Stata Stata NNP cord-324859-0yuhb5dl 167 18 . . . cord-324859-0yuhb5dl 168 1 There there EX cord-324859-0yuhb5dl 168 2 was be VBD cord-324859-0yuhb5dl 168 3 a a DT cord-324859-0yuhb5dl 168 4 strong strong JJ cord-324859-0yuhb5dl 168 5 evidence evidence NN cord-324859-0yuhb5dl 168 6 to to TO cord-324859-0yuhb5dl 168 7 suggest suggest VB cord-324859-0yuhb5dl 168 8 the the DT cord-324859-0yuhb5dl 168 9 possibility possibility NN cord-324859-0yuhb5dl 168 10 of of IN cord-324859-0yuhb5dl 168 11 a a DT cord-324859-0yuhb5dl 168 12 publication publication NN cord-324859-0yuhb5dl 168 13 bias bias NN cord-324859-0yuhb5dl 168 14 among among IN cord-324859-0yuhb5dl 168 15 studies study NNS cord-324859-0yuhb5dl 168 16 for for IN cord-324859-0yuhb5dl 168 17 the the DT cord-324859-0yuhb5dl 168 18 IL-6 IL-6 NNP cord-324859-0yuhb5dl 168 19 outcome outcome NN cord-324859-0yuhb5dl 168 20 ( ( -LRB- cord-324859-0yuhb5dl 168 21 P p NN cord-324859-0yuhb5dl 168 22 - - HYPH cord-324859-0yuhb5dl 168 23 value value NN cord-324859-0yuhb5dl 168 24 < < XX cord-324859-0yuhb5dl 168 25 .001 .001 CD cord-324859-0yuhb5dl 168 26 ) ) -RRB- cord-324859-0yuhb5dl 168 27 , , , cord-324859-0yuhb5dl 168 28 while while IN cord-324859-0yuhb5dl 168 29 the the DT cord-324859-0yuhb5dl 168 30 evidence evidence NN cord-324859-0yuhb5dl 168 31 for for IN cord-324859-0yuhb5dl 168 32 other other JJ cord-324859-0yuhb5dl 168 33 outcomes outcome NNS cord-324859-0yuhb5dl 168 34 was be VBD cord-324859-0yuhb5dl 168 35 not not RB cord-324859-0yuhb5dl 168 36 found find VBN cord-324859-0yuhb5dl 168 37 to to TO cord-324859-0yuhb5dl 168 38 be be VB cord-324859-0yuhb5dl 168 39 significant significant JJ cord-324859-0yuhb5dl 168 40 . . . cord-324859-0yuhb5dl 169 1 It -PRON- PRP cord-324859-0yuhb5dl 169 2 may may MD cord-324859-0yuhb5dl 169 3 be be VB cord-324859-0yuhb5dl 169 4 important important JJ cord-324859-0yuhb5dl 169 5 to to TO cord-324859-0yuhb5dl 169 6 note note VB cord-324859-0yuhb5dl 169 7 that that IN cord-324859-0yuhb5dl 169 8 given give VBN cord-324859-0yuhb5dl 169 9 the the DT cord-324859-0yuhb5dl 169 10 high high JJ cord-324859-0yuhb5dl 169 11 heterogeneity heterogeneity NN cord-324859-0yuhb5dl 169 12 among among IN cord-324859-0yuhb5dl 169 13 studies study NNS cord-324859-0yuhb5dl 169 14 for for IN cord-324859-0yuhb5dl 169 15 a a DT cord-324859-0yuhb5dl 169 16 majority majority NN cord-324859-0yuhb5dl 169 17 of of IN cord-324859-0yuhb5dl 169 18 the the DT cord-324859-0yuhb5dl 169 19 outcomes outcome NNS cord-324859-0yuhb5dl 169 20 , , , cord-324859-0yuhb5dl 169 21 as as RB cord-324859-0yuhb5dl 169 22 well well RB cord-324859-0yuhb5dl 169 23 as as IN cord-324859-0yuhb5dl 169 24 the the DT cord-324859-0yuhb5dl 169 25 fact fact NN cord-324859-0yuhb5dl 169 26 that that IN cord-324859-0yuhb5dl 169 27 such such JJ cord-324859-0yuhb5dl 169 28 bias bias NN cord-324859-0yuhb5dl 169 29 detection detection NN cord-324859-0yuhb5dl 169 30 tests test NNS cord-324859-0yuhb5dl 169 31 are be VBP cord-324859-0yuhb5dl 169 32 known know VBN cord-324859-0yuhb5dl 169 33 to to TO cord-324859-0yuhb5dl 169 34 be be VB cord-324859-0yuhb5dl 169 35 underpowered underpowere VBN cord-324859-0yuhb5dl 169 36 , , , cord-324859-0yuhb5dl 169 37 these these DT cord-324859-0yuhb5dl 169 38 observations observation NNS cord-324859-0yuhb5dl 169 39 need need VBP cord-324859-0yuhb5dl 169 40 to to TO cord-324859-0yuhb5dl 169 41 be be VB cord-324859-0yuhb5dl 169 42 interpreted interpret VBN cord-324859-0yuhb5dl 169 43 with with IN cord-324859-0yuhb5dl 169 44 caution caution NN cord-324859-0yuhb5dl 169 45 . . . cord-324859-0yuhb5dl 170 1 Based base VBN cord-324859-0yuhb5dl 170 2 on on IN cord-324859-0yuhb5dl 170 3 the the DT cord-324859-0yuhb5dl 170 4 reviewed review VBN cord-324859-0yuhb5dl 170 5 studies study NNS cord-324859-0yuhb5dl 170 6 , , , cord-324859-0yuhb5dl 170 7 we -PRON- PRP cord-324859-0yuhb5dl 170 8 found find VBD cord-324859-0yuhb5dl 170 9 that that IN cord-324859-0yuhb5dl 170 10 patients patient NNS cord-324859-0yuhb5dl 170 11 diagnosed diagnose VBN cord-324859-0yuhb5dl 170 12 with with IN cord-324859-0yuhb5dl 170 13 severe severe JJ cord-324859-0yuhb5dl 170 14 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 170 15 had have VBD cord-324859-0yuhb5dl 170 16 significantly significantly RB cord-324859-0yuhb5dl 170 17 higher high JJR cord-324859-0yuhb5dl 170 18 levels level NNS cord-324859-0yuhb5dl 170 19 of of IN cord-324859-0yuhb5dl 170 20 circulating circulate VBG cord-324859-0yuhb5dl 170 21 IL-6 IL-6 NNP cord-324859-0yuhb5dl 170 22 , , , cord-324859-0yuhb5dl 170 23 IL-8 IL-8 NNP cord-324859-0yuhb5dl 170 24 , , , cord-324859-0yuhb5dl 170 25 IL-10 IL-10 NNP cord-324859-0yuhb5dl 170 26 , , , cord-324859-0yuhb5dl 170 27 IL-2R IL-2R NNP cord-324859-0yuhb5dl 170 28 and and CC cord-324859-0yuhb5dl 170 29 TNF TNF NNP cord-324859-0yuhb5dl 170 30 - - HYPH cord-324859-0yuhb5dl 170 31 alpha alpha NN cord-324859-0yuhb5dl 170 32 , , , cord-324859-0yuhb5dl 170 33 as as IN cord-324859-0yuhb5dl 170 34 compared compare VBN cord-324859-0yuhb5dl 170 35 to to IN cord-324859-0yuhb5dl 170 36 the the DT cord-324859-0yuhb5dl 170 37 patients patient NNS cord-324859-0yuhb5dl 170 38 who who WP cord-324859-0yuhb5dl 170 39 had have VBD cord-324859-0yuhb5dl 170 40 a a DT cord-324859-0yuhb5dl 170 41 mild mild NN cord-324859-0yuhb5dl 170 42 - - HYPH cord-324859-0yuhb5dl 170 43 to to IN cord-324859-0yuhb5dl 170 44 - - HYPH cord-324859-0yuhb5dl 170 45 moderate moderate JJ cord-324859-0yuhb5dl 170 46 form form NN cord-324859-0yuhb5dl 170 47 of of IN cord-324859-0yuhb5dl 170 48 the the DT cord-324859-0yuhb5dl 170 49 disease disease NN cord-324859-0yuhb5dl 170 50 . . . cord-324859-0yuhb5dl 171 1 Similarly similarly RB cord-324859-0yuhb5dl 171 2 , , , cord-324859-0yuhb5dl 171 3 in in IN cord-324859-0yuhb5dl 171 4 the the DT cord-324859-0yuhb5dl 171 5 pooled pool VBN cord-324859-0yuhb5dl 171 6 analysis analysis NN cord-324859-0yuhb5dl 171 7 , , , cord-324859-0yuhb5dl 171 8 CD4 CD4 NNP cord-324859-0yuhb5dl 171 9 + + CC cord-324859-0yuhb5dl 171 10 T t NN cord-324859-0yuhb5dl 171 11 cells cell NNS cord-324859-0yuhb5dl 171 12 as as RB cord-324859-0yuhb5dl 171 13 well well RB cord-324859-0yuhb5dl 171 14 as as IN cord-324859-0yuhb5dl 171 15 CD8 CD8 NNP cord-324859-0yuhb5dl 171 16 + + CC cord-324859-0yuhb5dl 171 17 T T NNP cord-324859-0yuhb5dl 171 18 cells cell NNS cord-324859-0yuhb5dl 171 19 were be VBD cord-324859-0yuhb5dl 171 20 significantly significantly RB cord-324859-0yuhb5dl 171 21 reduced reduce VBN cord-324859-0yuhb5dl 171 22 in in IN cord-324859-0yuhb5dl 171 23 severely severely RB cord-324859-0yuhb5dl 171 24 ill ill JJ cord-324859-0yuhb5dl 171 25 patients patient NNS cord-324859-0yuhb5dl 171 26 as as IN cord-324859-0yuhb5dl 171 27 compared compare VBN cord-324859-0yuhb5dl 171 28 to to IN cord-324859-0yuhb5dl 171 29 those those DT cord-324859-0yuhb5dl 171 30 with with IN cord-324859-0yuhb5dl 171 31 mild mild JJ cord-324859-0yuhb5dl 171 32 - - HYPH cord-324859-0yuhb5dl 171 33 tomoderate tomoderate JJ cord-324859-0yuhb5dl 171 34 disease disease NN cord-324859-0yuhb5dl 171 35 . . . cord-324859-0yuhb5dl 172 1 Our -PRON- PRP$ cord-324859-0yuhb5dl 172 2 findings finding NNS cord-324859-0yuhb5dl 172 3 corroborate corroborate VBP cord-324859-0yuhb5dl 172 4 with with IN cord-324859-0yuhb5dl 172 5 the the DT cord-324859-0yuhb5dl 172 6 current current JJ cord-324859-0yuhb5dl 172 7 understanding understanding NN cord-324859-0yuhb5dl 172 8 of of IN cord-324859-0yuhb5dl 172 9 the the DT cord-324859-0yuhb5dl 172 10 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 172 11 immunopathogenesis immunopathogenesis NN cord-324859-0yuhb5dl 172 12 which which WDT cord-324859-0yuhb5dl 172 13 is be VBZ cord-324859-0yuhb5dl 172 14 largely largely RB cord-324859-0yuhb5dl 172 15 based base VBN cord-324859-0yuhb5dl 172 16 on on IN cord-324859-0yuhb5dl 172 17 findings finding NNS cord-324859-0yuhb5dl 172 18 from from IN cord-324859-0yuhb5dl 172 19 studies study NNS cord-324859-0yuhb5dl 172 20 on on IN cord-324859-0yuhb5dl 172 21 SARS SARS NNP cord-324859-0yuhb5dl 172 22 coronavirus coronavirus NN cord-324859-0yuhb5dl 172 23 ( ( -LRB- cord-324859-0yuhb5dl 172 24 SARS SARS NNP cord-324859-0yuhb5dl 172 25 - - HYPH cord-324859-0yuhb5dl 172 26 CoV CoV NNP cord-324859-0yuhb5dl 172 27 ) ) -RRB- cord-324859-0yuhb5dl 172 28 that that WDT cord-324859-0yuhb5dl 172 29 bears bear VBZ cord-324859-0yuhb5dl 172 30 nearly nearly RB cord-324859-0yuhb5dl 172 31 80 80 CD cord-324859-0yuhb5dl 172 32 % % NN cord-324859-0yuhb5dl 172 33 nucleic nucleic JJ cord-324859-0yuhb5dl 172 34 acid acid NN cord-324859-0yuhb5dl 172 35 homology homology NN cord-324859-0yuhb5dl 172 36 with with IN cord-324859-0yuhb5dl 172 37 SARS SARS NNP cord-324859-0yuhb5dl 172 38 - - HYPH cord-324859-0yuhb5dl 172 39 CoV-2 CoV-2 NNP cord-324859-0yuhb5dl 172 40 . . . cord-324859-0yuhb5dl 173 1 65 65 CD cord-324859-0yuhb5dl 174 1 , , , cord-324859-0yuhb5dl 174 2 66 66 CD cord-324859-0yuhb5dl 175 1 Following follow VBG cord-324859-0yuhb5dl 175 2 the the DT cord-324859-0yuhb5dl 175 3 virus virus NN cord-324859-0yuhb5dl 175 4 entry entry NN cord-324859-0yuhb5dl 175 5 into into IN cord-324859-0yuhb5dl 175 6 the the DT cord-324859-0yuhb5dl 175 7 lung lung NN cord-324859-0yuhb5dl 175 8 epithelial epithelial NN cord-324859-0yuhb5dl 175 9 cells cell NNS cord-324859-0yuhb5dl 175 10 , , , cord-324859-0yuhb5dl 175 11 the the DT cord-324859-0yuhb5dl 175 12 innate innate JJ cord-324859-0yuhb5dl 175 13 immune immune JJ cord-324859-0yuhb5dl 175 14 response response NN cord-324859-0yuhb5dl 175 15 is be VBZ cord-324859-0yuhb5dl 175 16 triggered trigger VBN cord-324859-0yuhb5dl 175 17 leading lead VBG cord-324859-0yuhb5dl 175 18 to to IN cord-324859-0yuhb5dl 175 19 the the DT cord-324859-0yuhb5dl 175 20 first first JJ cord-324859-0yuhb5dl 175 21 wave wave NN cord-324859-0yuhb5dl 175 22 of of IN cord-324859-0yuhb5dl 175 23 hypercytokinaemia hypercytokinaemia NNP cord-324859-0yuhb5dl 175 24 . . . cord-324859-0yuhb5dl 176 1 The the DT cord-324859-0yuhb5dl 176 2 delayed delay VBN cord-324859-0yuhb5dl 176 3 type type NN cord-324859-0yuhb5dl 177 1 I -PRON- PRP cord-324859-0yuhb5dl 177 2 interferon interferon RB cord-324859-0yuhb5dl 177 3 ( ( -LRB- cord-324859-0yuhb5dl 177 4 IFN IFN NNP cord-324859-0yuhb5dl 177 5 ) ) -RRB- cord-324859-0yuhb5dl 177 6 response response NN cord-324859-0yuhb5dl 177 7 in in IN cord-324859-0yuhb5dl 177 8 coronavirus coronavirus NN cord-324859-0yuhb5dl 177 9 infections infection NNS cord-324859-0yuhb5dl 177 10 is be VBZ cord-324859-0yuhb5dl 177 11 known know VBN cord-324859-0yuhb5dl 177 12 to to TO cord-324859-0yuhb5dl 177 13 be be VB cord-324859-0yuhb5dl 177 14 associated associate VBN cord-324859-0yuhb5dl 177 15 with with IN cord-324859-0yuhb5dl 177 16 more more JJR cord-324859-0yuhb5dl 177 17 severe severe JJ cord-324859-0yuhb5dl 177 18 forms form NNS cord-324859-0yuhb5dl 177 19 of of IN cord-324859-0yuhb5dl 177 20 the the DT cord-324859-0yuhb5dl 177 21 disease disease NN cord-324859-0yuhb5dl 177 22 resulting result VBG cord-324859-0yuhb5dl 177 23 in in IN cord-324859-0yuhb5dl 177 24 rapid rapid JJ cord-324859-0yuhb5dl 177 25 viral viral JJ cord-324859-0yuhb5dl 177 26 multiplication multiplication NN cord-324859-0yuhb5dl 177 27 and and CC cord-324859-0yuhb5dl 177 28 paradoxical paradoxical JJ cord-324859-0yuhb5dl 177 29 hyperinflammation hyperinflammation NN cord-324859-0yuhb5dl 177 30 induced induce VBN cord-324859-0yuhb5dl 177 31 by by IN cord-324859-0yuhb5dl 177 32 type type NN cord-324859-0yuhb5dl 177 33 I -PRON- PRP cord-324859-0yuhb5dl 177 34 interferons interferon NNS cord-324859-0yuhb5dl 177 35 . . . cord-324859-0yuhb5dl 178 1 67 67 CD cord-324859-0yuhb5dl 178 2 , , , cord-324859-0yuhb5dl 178 3 68 68 CD cord-324859-0yuhb5dl 178 4 Further further JJ cord-324859-0yuhb5dl 178 5 activation activation NN cord-324859-0yuhb5dl 178 6 of of IN cord-324859-0yuhb5dl 178 7 the the DT cord-324859-0yuhb5dl 178 8 type type NN cord-324859-0yuhb5dl 178 9 I -PRON- PRP cord-324859-0yuhb5dl 178 10 IFN IFN NNP cord-324859-0yuhb5dl 178 11 signalling signal VBG cord-324859-0yuhb5dl 178 12 pathways pathway NNS cord-324859-0yuhb5dl 178 13 leads lead VBZ cord-324859-0yuhb5dl 178 14 to to IN cord-324859-0yuhb5dl 178 15 a a DT cord-324859-0yuhb5dl 178 16 significant significant JJ cord-324859-0yuhb5dl 178 17 influx influx NN cord-324859-0yuhb5dl 178 18 of of IN cord-324859-0yuhb5dl 178 19 neutrophils neutrophil NNS cord-324859-0yuhb5dl 178 20 , , , cord-324859-0yuhb5dl 178 21 inflammatory inflammatory JJ cord-324859-0yuhb5dl 178 22 monocytes monocyte NNS cord-324859-0yuhb5dl 178 23 - - HYPH cord-324859-0yuhb5dl 178 24 macrophages macrophage NNS cord-324859-0yuhb5dl 178 25 , , , cord-324859-0yuhb5dl 178 26 dendritic dendritic JJ cord-324859-0yuhb5dl 178 27 cells cell NNS cord-324859-0yuhb5dl 178 28 and and CC cord-324859-0yuhb5dl 178 29 NK NK NNP cord-324859-0yuhb5dl 178 30 cells cell NNS cord-324859-0yuhb5dl 178 31 into into IN cord-324859-0yuhb5dl 178 32 the the DT cord-324859-0yuhb5dl 178 33 lungs lung NNS cord-324859-0yuhb5dl 178 34 . . . cord-324859-0yuhb5dl 179 1 These these DT cord-324859-0yuhb5dl 179 2 infiltrating infiltrate VBG cord-324859-0yuhb5dl 179 3 cells cell NNS cord-324859-0yuhb5dl 179 4 are be VBP cord-324859-0yuhb5dl 179 5 the the DT cord-324859-0yuhb5dl 179 6 major major JJ cord-324859-0yuhb5dl 179 7 source source NN cord-324859-0yuhb5dl 179 8 of of IN cord-324859-0yuhb5dl 179 9 inflammatory inflammatory JJ cord-324859-0yuhb5dl 179 10 cytokines cytokine NNS cord-324859-0yuhb5dl 179 11 that that WDT cord-324859-0yuhb5dl 179 12 set set VBD cord-324859-0yuhb5dl 179 13 off off RP cord-324859-0yuhb5dl 179 14 the the DT cord-324859-0yuhb5dl 179 15 second second JJ cord-324859-0yuhb5dl 179 16 wave wave NN cord-324859-0yuhb5dl 179 17 - - : cord-324859-0yuhb5dl 179 18 the the DT cord-324859-0yuhb5dl 179 19 dreaded dreaded JJ cord-324859-0yuhb5dl 179 20 cytokine cytokine NN cord-324859-0yuhb5dl 179 21 storm storm NN cord-324859-0yuhb5dl 179 22 . . . cord-324859-0yuhb5dl 180 1 69 69 CD cord-324859-0yuhb5dl 181 1 A a DT cord-324859-0yuhb5dl 181 2 characteristic characteristic JJ cord-324859-0yuhb5dl 181 3 feature feature NN cord-324859-0yuhb5dl 181 4 of of IN cord-324859-0yuhb5dl 181 5 severe severe JJ cord-324859-0yuhb5dl 181 6 COVID-19 covid-19 NN cord-324859-0yuhb5dl 181 7 is be VBZ cord-324859-0yuhb5dl 181 8 lymphopenia lymphopenia NNP cord-324859-0yuhb5dl 181 9 that that WDT cord-324859-0yuhb5dl 181 10 has have VBZ cord-324859-0yuhb5dl 181 11 been be VBN cord-324859-0yuhb5dl 181 12 ascribed ascribe VBN cord-324859-0yuhb5dl 181 13 to to IN cord-324859-0yuhb5dl 181 14 multiple multiple JJ cord-324859-0yuhb5dl 181 15 plausible plausible JJ cord-324859-0yuhb5dl 181 16 mechanisms mechanism NNS cord-324859-0yuhb5dl 181 17 including include VBG cord-324859-0yuhb5dl 181 18 direct direct JJ cord-324859-0yuhb5dl 181 19 viral viral JJ cord-324859-0yuhb5dl 181 20 cytopathic cytopathic JJ cord-324859-0yuhb5dl 181 21 effects effect NNS cord-324859-0yuhb5dl 181 22 , , , cord-324859-0yuhb5dl 181 23 inhibitory inhibitory JJ cord-324859-0yuhb5dl 181 24 effects effect NNS cord-324859-0yuhb5dl 181 25 of of IN cord-324859-0yuhb5dl 181 26 cytokines cytokine NNS cord-324859-0yuhb5dl 181 27 including include VBG cord-324859-0yuhb5dl 181 28 TNFalpha TNFalpha NNP cord-324859-0yuhb5dl 181 29 , , , cord-324859-0yuhb5dl 181 30 IL-6 IL-6 NNP cord-324859-0yuhb5dl 181 31 and and CC cord-324859-0yuhb5dl 181 32 IL-10 IL-10 NNP cord-324859-0yuhb5dl 181 33 , , , cord-324859-0yuhb5dl 181 34 and and CC cord-324859-0yuhb5dl 181 35 immune immune JJ cord-324859-0yuhb5dl 181 36 cell cell NN cord-324859-0yuhb5dl 181 37 redistribution redistribution NN cord-324859-0yuhb5dl 181 38 into into IN cord-324859-0yuhb5dl 181 39 the the DT cord-324859-0yuhb5dl 181 40 lungs lung NNS cord-324859-0yuhb5dl 181 41 and and CC cord-324859-0yuhb5dl 181 42 lymphoid lymphoid JJ cord-324859-0yuhb5dl 181 43 organs organ NNS cord-324859-0yuhb5dl 181 44 . . . cord-324859-0yuhb5dl 182 1 [ [ -LRB- cord-324859-0yuhb5dl 182 2 70 70 CD cord-324859-0yuhb5dl 182 3 ] ] -RRB- cord-324859-0yuhb5dl 182 4 [ [ -LRB- cord-324859-0yuhb5dl 182 5 71 71 CD cord-324859-0yuhb5dl 182 6 ] ] -RRB- cord-324859-0yuhb5dl 182 7 [ [ -LRB- cord-324859-0yuhb5dl 182 8 72 72 CD cord-324859-0yuhb5dl 182 9 ] ] -RRB- cord-324859-0yuhb5dl 183 1 Diminished Diminished NNP cord-324859-0yuhb5dl 183 2 T t NN cord-324859-0yuhb5dl 183 3 - - HYPH cord-324859-0yuhb5dl 183 4 cell cell NN cord-324859-0yuhb5dl 183 5 responses response NNS cord-324859-0yuhb5dl 183 6 are be VBP cord-324859-0yuhb5dl 183 7 known know VBN cord-324859-0yuhb5dl 183 8 to to TO cord-324859-0yuhb5dl 183 9 further far RBR cord-324859-0yuhb5dl 183 10 retard retard VB cord-324859-0yuhb5dl 183 11 viral viral JJ cord-324859-0yuhb5dl 183 12 clearance clearance NN cord-324859-0yuhb5dl 183 13 , , , cord-324859-0yuhb5dl 183 14 thus thus RB cord-324859-0yuhb5dl 183 15 leading lead VBG cord-324859-0yuhb5dl 183 16 to to IN cord-324859-0yuhb5dl 183 17 a a DT cord-324859-0yuhb5dl 183 18 cytokine cytokine NN cord-324859-0yuhb5dl 183 19 - - HYPH cord-324859-0yuhb5dl 183 20 driven drive VBN cord-324859-0yuhb5dl 183 21 vicious vicious JJ cord-324859-0yuhb5dl 183 22 cycle cycle NN cord-324859-0yuhb5dl 183 23 . . . cord-324859-0yuhb5dl 184 1 The the DT cord-324859-0yuhb5dl 184 2 hyperinflammatory hyperinflammatory JJ cord-324859-0yuhb5dl 184 3 state state NN cord-324859-0yuhb5dl 184 4 eventually eventually RB cord-324859-0yuhb5dl 184 5 leads lead VBZ cord-324859-0yuhb5dl 184 6 to to IN cord-324859-0yuhb5dl 184 7 significant significant JJ cord-324859-0yuhb5dl 184 8 damage damage NN cord-324859-0yuhb5dl 184 9 to to IN cord-324859-0yuhb5dl 184 10 the the DT cord-324859-0yuhb5dl 184 11 lung lung NN cord-324859-0yuhb5dl 184 12 microvasculature microvasculature NN cord-324859-0yuhb5dl 184 13 and and CC cord-324859-0yuhb5dl 184 14 alveolar alveolar NN cord-324859-0yuhb5dl 184 15 epithelium epithelium NN cord-324859-0yuhb5dl 184 16 causing cause VBG cord-324859-0yuhb5dl 184 17 vascular vascular JJ cord-324859-0yuhb5dl 184 18 leakage leakage NN cord-324859-0yuhb5dl 184 19 and and CC cord-324859-0yuhb5dl 184 20 alveolar alveolar NN cord-324859-0yuhb5dl 184 21 oedema oedema NN cord-324859-0yuhb5dl 184 22 resulting result VBG cord-324859-0yuhb5dl 184 23 in in IN cord-324859-0yuhb5dl 184 24 life life NN cord-324859-0yuhb5dl 184 25 - - HYPH cord-324859-0yuhb5dl 184 26 threatening threaten VBG cord-324859-0yuhb5dl 184 27 acute acute JJ cord-324859-0yuhb5dl 184 28 respiratory respiratory JJ cord-324859-0yuhb5dl 184 29 distress distress NN cord-324859-0yuhb5dl 184 30 syndrome syndrome NN cord-324859-0yuhb5dl 184 31 ( ( -LRB- cord-324859-0yuhb5dl 184 32 ARDS ARDS NNP cord-324859-0yuhb5dl 184 33 ) ) -RRB- cord-324859-0yuhb5dl 184 34 . . . cord-324859-0yuhb5dl 185 1 These these DT cord-324859-0yuhb5dl 185 2 cytokines cytokine NNS cord-324859-0yuhb5dl 185 3 and and CC cord-324859-0yuhb5dl 185 4 chemokines chemokine NNS cord-324859-0yuhb5dl 185 5 have have VBP cord-324859-0yuhb5dl 185 6 also also RB cord-324859-0yuhb5dl 185 7 been be VBN cord-324859-0yuhb5dl 185 8 linked link VBN cord-324859-0yuhb5dl 185 9 to to IN cord-324859-0yuhb5dl 185 10 extrapulmonary extrapulmonary JJ cord-324859-0yuhb5dl 185 11 complications complication NNS cord-324859-0yuhb5dl 185 12 of of IN cord-324859-0yuhb5dl 185 13 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 185 14 including include VBG cord-324859-0yuhb5dl 185 15 multiple multiple JJ cord-324859-0yuhb5dl 185 16 - - HYPH cord-324859-0yuhb5dl 185 17 organ organ NN cord-324859-0yuhb5dl 185 18 dysfunction dysfunction NN cord-324859-0yuhb5dl 185 19 syndrome syndrome NN cord-324859-0yuhb5dl 185 20 . . . cord-324859-0yuhb5dl 186 1 73 73 CD cord-324859-0yuhb5dl 187 1 these these DT cord-324859-0yuhb5dl 187 2 proposed propose VBN cord-324859-0yuhb5dl 187 3 mechanisms mechanism NNS cord-324859-0yuhb5dl 187 4 , , , cord-324859-0yuhb5dl 187 5 we -PRON- PRP cord-324859-0yuhb5dl 187 6 found find VBD cord-324859-0yuhb5dl 187 7 significantly significantly RB cord-324859-0yuhb5dl 187 8 higher high JJR cord-324859-0yuhb5dl 187 9 circulating circulate VBG cord-324859-0yuhb5dl 187 10 levels level NNS cord-324859-0yuhb5dl 187 11 of of IN cord-324859-0yuhb5dl 187 12 pro pro JJ cord-324859-0yuhb5dl 187 13 - - JJ cord-324859-0yuhb5dl 187 14 inflammatory inflammatory JJ cord-324859-0yuhb5dl 187 15 markers marker NNS cord-324859-0yuhb5dl 188 1 IL-6 IL-6 NNP cord-324859-0yuhb5dl 188 2 , , , cord-324859-0yuhb5dl 188 3 IL-2R IL-2R NNP cord-324859-0yuhb5dl 188 4 and and CC cord-324859-0yuhb5dl 188 5 TNF TNF NNP cord-324859-0yuhb5dl 188 6 - - HYPH cord-324859-0yuhb5dl 188 7 alpha alpha NN cord-324859-0yuhb5dl 188 8 among among IN cord-324859-0yuhb5dl 188 9 patients patient NNS cord-324859-0yuhb5dl 188 10 diagnosed diagnose VBN cord-324859-0yuhb5dl 188 11 with with IN cord-324859-0yuhb5dl 188 12 severe severe JJ cord-324859-0yuhb5dl 188 13 COVID-19 covid-19 NN cord-324859-0yuhb5dl 189 1 as as IN cord-324859-0yuhb5dl 189 2 compared compare VBN cord-324859-0yuhb5dl 189 3 to to IN cord-324859-0yuhb5dl 189 4 the the DT cord-324859-0yuhb5dl 189 5 non non JJ cord-324859-0yuhb5dl 189 6 - - JJ cord-324859-0yuhb5dl 189 7 severe severe JJ cord-324859-0yuhb5dl 189 8 cases case NNS cord-324859-0yuhb5dl 189 9 . . . cord-324859-0yuhb5dl 190 1 IL-8 IL-8 NNP cord-324859-0yuhb5dl 190 2 , , , cord-324859-0yuhb5dl 190 3 also also RB cord-324859-0yuhb5dl 190 4 known know VBN cord-324859-0yuhb5dl 190 5 as as IN cord-324859-0yuhb5dl 190 6 CXCL8 CXCL8 NNP cord-324859-0yuhb5dl 190 7 , , , cord-324859-0yuhb5dl 190 8 is be VBZ cord-324859-0yuhb5dl 190 9 a a DT cord-324859-0yuhb5dl 190 10 key key JJ cord-324859-0yuhb5dl 190 11 regulator regulator NN cord-324859-0yuhb5dl 190 12 of of IN cord-324859-0yuhb5dl 190 13 neutrophil neutrophil NN cord-324859-0yuhb5dl 190 14 and and CC cord-324859-0yuhb5dl 190 15 monocyte monocyte NN cord-324859-0yuhb5dl 190 16 chemotaxis chemotaxis NN cord-324859-0yuhb5dl 190 17 in in IN cord-324859-0yuhb5dl 190 18 the the DT cord-324859-0yuhb5dl 190 19 lungs lung NNS cord-324859-0yuhb5dl 190 20 and and CC cord-324859-0yuhb5dl 190 21 is be VBZ cord-324859-0yuhb5dl 190 22 considered consider VBN cord-324859-0yuhb5dl 190 23 to to TO cord-324859-0yuhb5dl 190 24 be be VB cord-324859-0yuhb5dl 190 25 a a DT cord-324859-0yuhb5dl 190 26 prognostic prognostic JJ cord-324859-0yuhb5dl 190 27 marker marker NN cord-324859-0yuhb5dl 190 28 for for IN cord-324859-0yuhb5dl 190 29 the the DT cord-324859-0yuhb5dl 190 30 clinical clinical JJ cord-324859-0yuhb5dl 190 31 course course NN cord-324859-0yuhb5dl 190 32 of of IN cord-324859-0yuhb5dl 190 33 ARDS ARDS NNP cord-324859-0yuhb5dl 190 34 . . . cord-324859-0yuhb5dl 191 1 75 75 CD cord-324859-0yuhb5dl 191 2 , , , cord-324859-0yuhb5dl 191 3 76 76 CD cord-324859-0yuhb5dl 192 1 In in IN cord-324859-0yuhb5dl 192 2 patients patient NNS cord-324859-0yuhb5dl 192 3 with with IN cord-324859-0yuhb5dl 192 4 acute acute JJ cord-324859-0yuhb5dl 192 5 lung lung NN cord-324859-0yuhb5dl 192 6 injury injury NN cord-324859-0yuhb5dl 192 7 , , , cord-324859-0yuhb5dl 192 8 elevated elevated JJ cord-324859-0yuhb5dl 192 9 plasma plasma NN cord-324859-0yuhb5dl 192 10 IL-8 il-8 NN cord-324859-0yuhb5dl 192 11 levels level NNS cord-324859-0yuhb5dl 192 12 have have VBP cord-324859-0yuhb5dl 192 13 been be VBN cord-324859-0yuhb5dl 192 14 associated associate VBN cord-324859-0yuhb5dl 192 15 with with IN cord-324859-0yuhb5dl 192 16 an an DT cord-324859-0yuhb5dl 192 17 increased increase VBN cord-324859-0yuhb5dl 192 18 risk risk NN cord-324859-0yuhb5dl 192 19 of of IN cord-324859-0yuhb5dl 192 20 mortality mortality NN cord-324859-0yuhb5dl 192 21 , , , cord-324859-0yuhb5dl 192 22 as as RB cord-324859-0yuhb5dl 192 23 well well RB cord-324859-0yuhb5dl 192 24 as as IN cord-324859-0yuhb5dl 192 25 reduced reduce VBN cord-324859-0yuhb5dl 192 26 ventilator ventilator NN cord-324859-0yuhb5dl 192 27 - - HYPH cord-324859-0yuhb5dl 192 28 free free JJ cord-324859-0yuhb5dl 192 29 and and CC cord-324859-0yuhb5dl 192 30 organ organ NN cord-324859-0yuhb5dl 192 31 failure failure NN cord-324859-0yuhb5dl 192 32 - - HYPH cord-324859-0yuhb5dl 192 33 free free JJ cord-324859-0yuhb5dl 192 34 days day NNS cord-324859-0yuhb5dl 192 35 . . . cord-324859-0yuhb5dl 193 1 77 77 CD cord-324859-0yuhb5dl 194 1 In in IN cord-324859-0yuhb5dl 194 2 contrast contrast NN cord-324859-0yuhb5dl 194 3 to to IN cord-324859-0yuhb5dl 194 4 SARS SARS NNP cord-324859-0yuhb5dl 194 5 , , , cord-324859-0yuhb5dl 194 6 we -PRON- PRP cord-324859-0yuhb5dl 194 7 found find VBD cord-324859-0yuhb5dl 194 8 elevated elevated JJ cord-324859-0yuhb5dl 194 9 levels level NNS cord-324859-0yuhb5dl 194 10 of of IN cord-324859-0yuhb5dl 194 11 IL-10 IL-10 NNP cord-324859-0yuhb5dl 194 12 , , , cord-324859-0yuhb5dl 194 13 a a DT cord-324859-0yuhb5dl 194 14 T t NN cord-324859-0yuhb5dl 194 15 helper helper NN cord-324859-0yuhb5dl 194 16 type type NN cord-324859-0yuhb5dl 194 17 2 2 CD cord-324859-0yuhb5dl 195 1 ( ( -LRB- cord-324859-0yuhb5dl 195 2 Th2 th2 CD cord-324859-0yuhb5dl 195 3 ) ) -RRB- cord-324859-0yuhb5dl 195 4 cellsecreted cellsecrete VBN cord-324859-0yuhb5dl 195 5 cytokine cytokine NN cord-324859-0yuhb5dl 195 6 and and CC cord-324859-0yuhb5dl 195 7 an an DT cord-324859-0yuhb5dl 195 8 inhibitor inhibitor NN cord-324859-0yuhb5dl 195 9 of of IN cord-324859-0yuhb5dl 195 10 inflammatory inflammatory JJ cord-324859-0yuhb5dl 195 11 response response NN cord-324859-0yuhb5dl 195 12 , , , cord-324859-0yuhb5dl 195 13 in in IN cord-324859-0yuhb5dl 195 14 severe severe JJ cord-324859-0yuhb5dl 195 15 COVID-19 covid-19 JJ cord-324859-0yuhb5dl 195 16 patients patient NNS cord-324859-0yuhb5dl 195 17 as as IN cord-324859-0yuhb5dl 195 18 compared compare VBN cord-324859-0yuhb5dl 195 19 to to IN cord-324859-0yuhb5dl 195 20 non non JJ cord-324859-0yuhb5dl 195 21 - - JJ cord-324859-0yuhb5dl 195 22 severe severe JJ cord-324859-0yuhb5dl 195 23 cases case NNS cord-324859-0yuhb5dl 195 24 . . . cord-324859-0yuhb5dl 196 1 Higher high JJR cord-324859-0yuhb5dl 196 2 levels level NNS cord-324859-0yuhb5dl 196 3 of of IN cord-324859-0yuhb5dl 196 4 IL-10 IL-10 NNP cord-324859-0yuhb5dl 196 5 have have VBP cord-324859-0yuhb5dl 196 6 also also RB cord-324859-0yuhb5dl 196 7 been be VBN cord-324859-0yuhb5dl 196 8 associated associate VBN cord-324859-0yuhb5dl 196 9 with with IN cord-324859-0yuhb5dl 196 10 increased increase VBN cord-324859-0yuhb5dl 196 11 expression expression NN cord-324859-0yuhb5dl 196 12 of of IN cord-324859-0yuhb5dl 196 13 T t NN cord-324859-0yuhb5dl 196 14 - - HYPH cord-324859-0yuhb5dl 196 15 cell cell NN cord-324859-0yuhb5dl 196 16 exhaustion exhaustion NN cord-324859-0yuhb5dl 196 17 markers marker NNS cord-324859-0yuhb5dl 196 18 , , , cord-324859-0yuhb5dl 196 19 PD-1 PD-1 NNP cord-324859-0yuhb5dl 196 20 and and CC cord-324859-0yuhb5dl 196 21 Tim-3 Tim-3 NNP cord-324859-0yuhb5dl 196 22 , , , cord-324859-0yuhb5dl 196 23 in in IN cord-324859-0yuhb5dl 196 24 COVID-19 covid-19 JJ cord-324859-0yuhb5dl 196 25 patients patient NNS cord-324859-0yuhb5dl 196 26 and and CC cord-324859-0yuhb5dl 196 27 their -PRON- PRP$ cord-324859-0yuhb5dl 196 28 consequently consequently RB cord-324859-0yuhb5dl 196 29 impaired impair VBN cord-324859-0yuhb5dl 196 30 ability ability NN cord-324859-0yuhb5dl 196 31 to to TO cord-324859-0yuhb5dl 196 32 clear clear VB cord-324859-0yuhb5dl 196 33 viral viral JJ cord-324859-0yuhb5dl 196 34 infections infection NNS cord-324859-0yuhb5dl 196 35 especially especially RB cord-324859-0yuhb5dl 196 36 in in IN cord-324859-0yuhb5dl 196 37 severely severely RB cord-324859-0yuhb5dl 196 38 affected affect VBN cord-324859-0yuhb5dl 196 39 individuals individual NNS cord-324859-0yuhb5dl 196 40 . . . cord-324859-0yuhb5dl 197 1 78 78 CD cord-324859-0yuhb5dl 198 1 The the DT cord-324859-0yuhb5dl 198 2 difference difference NN cord-324859-0yuhb5dl 198 3 in in IN cord-324859-0yuhb5dl 198 4 levels level NNS cord-324859-0yuhb5dl 198 5 of of IN cord-324859-0yuhb5dl 198 6 TNF tnf NN cord-324859-0yuhb5dl 198 7 - - HYPH cord-324859-0yuhb5dl 198 8 alpha alpha NN cord-324859-0yuhb5dl 198 9 though though IN cord-324859-0yuhb5dl 198 10 significant significant JJ cord-324859-0yuhb5dl 198 11 was be VBD cord-324859-0yuhb5dl 198 12 not not RB cord-324859-0yuhb5dl 198 13 pronounced pronounce VBN cord-324859-0yuhb5dl 198 14 , , , cord-324859-0yuhb5dl 198 15 which which WDT cord-324859-0yuhb5dl 198 16 could could MD cord-324859-0yuhb5dl 198 17 be be VB cord-324859-0yuhb5dl 198 18 a a DT cord-324859-0yuhb5dl 198 19 consequence consequence NN cord-324859-0yuhb5dl 198 20 of of IN cord-324859-0yuhb5dl 198 21 lesser less JJR cord-324859-0yuhb5dl 198 22 number number NN cord-324859-0yuhb5dl 198 23 of of IN cord-324859-0yuhb5dl 198 24 studies study NNS cord-324859-0yuhb5dl 198 25 reporting report VBG cord-324859-0yuhb5dl 198 26 the the DT cord-324859-0yuhb5dl 198 27 outcome outcome NN cord-324859-0yuhb5dl 198 28 as as RB cord-324859-0yuhb5dl 198 29 well well RB cord-324859-0yuhb5dl 198 30 as as IN cord-324859-0yuhb5dl 198 31 the the DT cord-324859-0yuhb5dl 198 32 rather rather RB cord-324859-0yuhb5dl 198 33 small small JJ cord-324859-0yuhb5dl 198 34 sample sample NN cord-324859-0yuhb5dl 198 35 sizes size NNS cord-324859-0yuhb5dl 198 36 of of IN cord-324859-0yuhb5dl 198 37 a a DT cord-324859-0yuhb5dl 198 38 majority majority NN cord-324859-0yuhb5dl 198 39 of of IN cord-324859-0yuhb5dl 198 40 the the DT cord-324859-0yuhb5dl 198 41 included include VBN cord-324859-0yuhb5dl 198 42 studies study NNS cord-324859-0yuhb5dl 198 43 . . . cord-324859-0yuhb5dl 199 1 We -PRON- PRP cord-324859-0yuhb5dl 199 2 found find VBD cord-324859-0yuhb5dl 199 3 a a DT cord-324859-0yuhb5dl 199 4 significant significant JJ cord-324859-0yuhb5dl 199 5 reduction reduction NN cord-324859-0yuhb5dl 199 6 in in IN cord-324859-0yuhb5dl 199 7 lymphocyte lymphocyte NN cord-324859-0yuhb5dl 199 8 counts count NNS cord-324859-0yuhb5dl 199 9 - - : cord-324859-0yuhb5dl 199 10 both both DT cord-324859-0yuhb5dl 199 11 CD4 CD4 NNP cord-324859-0yuhb5dl 199 12 + + CC cord-324859-0yuhb5dl 199 13 and and CC cord-324859-0yuhb5dl 199 14 CD8 CD8 NNP cord-324859-0yuhb5dl 199 15 + + CC cord-324859-0yuhb5dl 199 16 in in IN cord-324859-0yuhb5dl 199 17 patients patient NNS cord-324859-0yuhb5dl 199 18 diagnosed diagnose VBN cord-324859-0yuhb5dl 199 19 with with IN cord-324859-0yuhb5dl 199 20 severe severe JJ cord-324859-0yuhb5dl 199 21 COVID-19 covid-19 NN cord-324859-0yuhb5dl 199 22 . . . cord-324859-0yuhb5dl 200 1 Similar similar JJ cord-324859-0yuhb5dl 200 2 findings finding NNS cord-324859-0yuhb5dl 200 3 have have VBP cord-324859-0yuhb5dl 200 4 also also RB cord-324859-0yuhb5dl 200 5 been be VBN cord-324859-0yuhb5dl 200 6 reported report VBN cord-324859-0yuhb5dl 200 7 for for IN cord-324859-0yuhb5dl 200 8 SARS SARS NNP cord-324859-0yuhb5dl 200 9 as as RB cord-324859-0yuhb5dl 200 10 well well RB cord-324859-0yuhb5dl 200 11 as as IN cord-324859-0yuhb5dl 200 12 MERS MERS NNPS cord-324859-0yuhb5dl 200 13 and and CC cord-324859-0yuhb5dl 200 14 have have VBP cord-324859-0yuhb5dl 200 15 been be VBN cord-324859-0yuhb5dl 200 16 linked link VBN cord-324859-0yuhb5dl 200 17 to to IN cord-324859-0yuhb5dl 200 18 disease disease NN cord-324859-0yuhb5dl 200 19 severity severity NN cord-324859-0yuhb5dl 200 20 and and CC cord-324859-0yuhb5dl 200 21 adverse adverse JJ cord-324859-0yuhb5dl 200 22 outcomes outcome NNS cord-324859-0yuhb5dl 200 23 in in IN cord-324859-0yuhb5dl 200 24 these these DT cord-324859-0yuhb5dl 200 25 patients patient NNS cord-324859-0yuhb5dl 200 26 . . . cord-324859-0yuhb5dl 201 1 [ [ -LRB- cord-324859-0yuhb5dl 201 2 79 79 CD cord-324859-0yuhb5dl 201 3 ] ] -RRB- cord-324859-0yuhb5dl 201 4 [ [ -LRB- cord-324859-0yuhb5dl 201 5 80 80 CD cord-324859-0yuhb5dl 201 6 ] ] -RRB- cord-324859-0yuhb5dl 202 1 [ [ -LRB- cord-324859-0yuhb5dl 202 2 81 81 CD cord-324859-0yuhb5dl 202 3 ] ] -RRB- cord-324859-0yuhb5dl 203 1 [ [ -LRB- cord-324859-0yuhb5dl 203 2 82 82 CD cord-324859-0yuhb5dl 203 3 ] ] -RRB- cord-324859-0yuhb5dl 204 1 [ [ -LRB- cord-324859-0yuhb5dl 204 2 83 83 CD cord-324859-0yuhb5dl 204 3 ] ] -RRB- cord-324859-0yuhb5dl 205 1 In in IN cord-324859-0yuhb5dl 205 2 follow follow NN cord-324859-0yuhb5dl 205 3 - - HYPH cord-324859-0yuhb5dl 205 4 up up NN cord-324859-0yuhb5dl 205 5 studies study NNS cord-324859-0yuhb5dl 205 6 in in IN cord-324859-0yuhb5dl 205 7 patients patient NNS cord-324859-0yuhb5dl 205 8 with with IN cord-324859-0yuhb5dl 205 9 SARS SARS NNP cord-324859-0yuhb5dl 205 10 , , , cord-324859-0yuhb5dl 205 11 it -PRON- PRP cord-324859-0yuhb5dl 205 12 was be VBD cord-324859-0yuhb5dl 205 13 shown show VBN cord-324859-0yuhb5dl 205 14 that that IN cord-324859-0yuhb5dl 205 15 while while IN cord-324859-0yuhb5dl 205 16 CD8 CD8 NNP cord-324859-0yuhb5dl 205 17 + + CC cord-324859-0yuhb5dl 205 18 T T NNP cord-324859-0yuhb5dl 205 19 lymphocytes lymphocyte NNS cord-324859-0yuhb5dl 205 20 return return VBP cord-324859-0yuhb5dl 205 21 to to IN cord-324859-0yuhb5dl 205 22 normal normal JJ cord-324859-0yuhb5dl 205 23 levels level NNS cord-324859-0yuhb5dl 205 24 in in IN cord-324859-0yuhb5dl 205 25 2 2 CD cord-324859-0yuhb5dl 205 26 - - SYM cord-324859-0yuhb5dl 205 27 3 3 CD cord-324859-0yuhb5dl 205 28 months month NNS cord-324859-0yuhb5dl 205 29 , , , cord-324859-0yuhb5dl 205 30 memory memory NN cord-324859-0yuhb5dl 205 31 CD4 CD4 NNP cord-324859-0yuhb5dl 205 32 + + CC cord-324859-0yuhb5dl 205 33 T t NN cord-324859-0yuhb5dl 205 34 cells cell NNS cord-324859-0yuhb5dl 205 35 can can MD cord-324859-0yuhb5dl 205 36 take take VB cord-324859-0yuhb5dl 205 37 up up RP cord-324859-0yuhb5dl 205 38 to to IN cord-324859-0yuhb5dl 205 39 a a DT cord-324859-0yuhb5dl 205 40 year year NN cord-324859-0yuhb5dl 205 41 for for IN cord-324859-0yuhb5dl 205 42 full full JJ cord-324859-0yuhb5dl 205 43 recovery recovery NN cord-324859-0yuhb5dl 205 44 . . . cord-324859-0yuhb5dl 206 1 84 84 CD cord-324859-0yuhb5dl 207 1 Our -PRON- PRP$ cord-324859-0yuhb5dl 207 2 findings finding NNS cord-324859-0yuhb5dl 207 3 can can MD cord-324859-0yuhb5dl 207 4 have have VB cord-324859-0yuhb5dl 207 5 important important JJ cord-324859-0yuhb5dl 207 6 clinical clinical JJ cord-324859-0yuhb5dl 207 7 implications implication NNS cord-324859-0yuhb5dl 207 8 for for IN cord-324859-0yuhb5dl 207 9 diagnostic diagnostic JJ cord-324859-0yuhb5dl 207 10 as as RB cord-324859-0yuhb5dl 207 11 well well RB cord-324859-0yuhb5dl 207 12 as as IN cord-324859-0yuhb5dl 207 13 therapeutic therapeutic JJ cord-324859-0yuhb5dl 207 14 purposes purpose NNS cord-324859-0yuhb5dl 207 15 of of IN cord-324859-0yuhb5dl 207 16 COVID-19 covid-19 JJ cord-324859-0yuhb5dl 207 17 management management NN cord-324859-0yuhb5dl 207 18 . . . cord-324859-0yuhb5dl 208 1 Currently currently RB cord-324859-0yuhb5dl 208 2 , , , cord-324859-0yuhb5dl 208 3 there there EX cord-324859-0yuhb5dl 208 4 is be VBZ cord-324859-0yuhb5dl 208 5 no no DT cord-324859-0yuhb5dl 208 6 consensus consensus NN cord-324859-0yuhb5dl 208 7 on on IN cord-324859-0yuhb5dl 208 8 the the DT cord-324859-0yuhb5dl 208 9 utility utility NN cord-324859-0yuhb5dl 208 10 of of IN cord-324859-0yuhb5dl 208 11 serial serial JJ cord-324859-0yuhb5dl 208 12 immune immune JJ cord-324859-0yuhb5dl 208 13 monitoring monitoring NN cord-324859-0yuhb5dl 208 14 in in IN cord-324859-0yuhb5dl 208 15 patients patient NNS cord-324859-0yuhb5dl 208 16 with with IN cord-324859-0yuhb5dl 208 17 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 208 18 . . . cord-324859-0yuhb5dl 209 1 Based base VBN cord-324859-0yuhb5dl 209 2 on on IN cord-324859-0yuhb5dl 209 3 our -PRON- PRP$ cord-324859-0yuhb5dl 209 4 findings finding NNS cord-324859-0yuhb5dl 209 5 , , , cord-324859-0yuhb5dl 209 6 cytokine cytokine NN cord-324859-0yuhb5dl 209 7 - - : cord-324859-0yuhb5dl 209 8 IL-6 IL-6 NNP cord-324859-0yuhb5dl 209 9 , , , cord-324859-0yuhb5dl 209 10 IL-8 IL-8 NNP cord-324859-0yuhb5dl 209 11 , , , cord-324859-0yuhb5dl 209 12 IL-10 IL-10 NNP cord-324859-0yuhb5dl 209 13 , , , cord-324859-0yuhb5dl 209 14 IL-2R IL-2R NNP cord-324859-0yuhb5dl 209 15 and and CC cord-324859-0yuhb5dl 209 16 TNF TNF NNP cord-324859-0yuhb5dl 209 17 - - HYPH cord-324859-0yuhb5dl 209 18 alphalevels alphalevels NNP cord-324859-0yuhb5dl 209 19 can can MD cord-324859-0yuhb5dl 209 20 serve serve VB cord-324859-0yuhb5dl 209 21 as as IN cord-324859-0yuhb5dl 209 22 potential potential JJ cord-324859-0yuhb5dl 209 23 prognostic prognostic JJ cord-324859-0yuhb5dl 209 24 biomarkers biomarker NNS cord-324859-0yuhb5dl 209 25 for for IN cord-324859-0yuhb5dl 209 26 risk risk NN cord-324859-0yuhb5dl 209 27 stratification stratification NN cord-324859-0yuhb5dl 209 28 of of IN cord-324859-0yuhb5dl 209 29 COVID-19 covid-19 JJ cord-324859-0yuhb5dl 209 30 patients patient NNS cord-324859-0yuhb5dl 209 31 . . . cord-324859-0yuhb5dl 210 1 An an DT cord-324859-0yuhb5dl 210 2 important important JJ cord-324859-0yuhb5dl 210 3 question question NN cord-324859-0yuhb5dl 210 4 that that WDT cord-324859-0yuhb5dl 210 5 is be VBZ cord-324859-0yuhb5dl 210 6 yet yet RB cord-324859-0yuhb5dl 210 7 to to TO cord-324859-0yuhb5dl 210 8 be be VB cord-324859-0yuhb5dl 210 9 answered answer VBN cord-324859-0yuhb5dl 210 10 is be VBZ cord-324859-0yuhb5dl 210 11 whether whether IN cord-324859-0yuhb5dl 210 12 the the DT cord-324859-0yuhb5dl 210 13 therapeutic therapeutic JJ cord-324859-0yuhb5dl 210 14 blockade blockade NN cord-324859-0yuhb5dl 210 15 of of IN cord-324859-0yuhb5dl 210 16 IL-6 IL-6 NNP cord-324859-0yuhb5dl 210 17 is be VBZ cord-324859-0yuhb5dl 210 18 considered consider VBN cord-324859-0yuhb5dl 210 19 only only RB cord-324859-0yuhb5dl 210 20 in in IN cord-324859-0yuhb5dl 210 21 patients patient NNS cord-324859-0yuhb5dl 210 22 with with IN cord-324859-0yuhb5dl 210 23 elevated elevated JJ cord-324859-0yuhb5dl 210 24 IL-6 IL-6 NNP cord-324859-0yuhb5dl 210 25 levels level NNS cord-324859-0yuhb5dl 210 26 since since IN cord-324859-0yuhb5dl 210 27 variability variability NN cord-324859-0yuhb5dl 210 28 has have VBZ cord-324859-0yuhb5dl 210 29 been be VBN cord-324859-0yuhb5dl 210 30 noted note VBN cord-324859-0yuhb5dl 210 31 in in IN cord-324859-0yuhb5dl 210 32 individual individual JJ cord-324859-0yuhb5dl 210 33 studies study NNS cord-324859-0yuhb5dl 210 34 comparing compare VBG cord-324859-0yuhb5dl 210 35 severe severe JJ cord-324859-0yuhb5dl 210 36 and and CC cord-324859-0yuhb5dl 210 37 non non JJ cord-324859-0yuhb5dl 210 38 - - JJ cord-324859-0yuhb5dl 210 39 severe severe JJ cord-324859-0yuhb5dl 210 40 cases case NNS cord-324859-0yuhb5dl 210 41 . . . cord-324859-0yuhb5dl 211 1 For for IN cord-324859-0yuhb5dl 211 2 this this DT cord-324859-0yuhb5dl 211 3 , , , cord-324859-0yuhb5dl 211 4 the the DT cord-324859-0yuhb5dl 211 5 cut cut VB cord-324859-0yuhb5dl 211 6 - - HYPH cord-324859-0yuhb5dl 211 7 off off RP cord-324859-0yuhb5dl 211 8 values value NNS cord-324859-0yuhb5dl 211 9 for for IN cord-324859-0yuhb5dl 211 10 initiation initiation NN cord-324859-0yuhb5dl 211 11 of of IN cord-324859-0yuhb5dl 211 12 therapy therapy NN cord-324859-0yuhb5dl 211 13 will will MD cord-324859-0yuhb5dl 211 14 need need VB cord-324859-0yuhb5dl 211 15 to to TO cord-324859-0yuhb5dl 211 16 be be VB cord-324859-0yuhb5dl 211 17 defined define VBN cord-324859-0yuhb5dl 211 18 based base VBN cord-324859-0yuhb5dl 211 19 on on IN cord-324859-0yuhb5dl 211 20 well well RB cord-324859-0yuhb5dl 211 21 - - HYPH cord-324859-0yuhb5dl 211 22 designed design VBN cord-324859-0yuhb5dl 211 23 and and CC cord-324859-0yuhb5dl 211 24 adequately adequately RB cord-324859-0yuhb5dl 211 25 powered powered JJ cord-324859-0yuhb5dl 211 26 prospective prospective JJ cord-324859-0yuhb5dl 211 27 studies study NNS cord-324859-0yuhb5dl 211 28 . . . cord-324859-0yuhb5dl 212 1 Screening screening NN cord-324859-0yuhb5dl 212 2 of of IN cord-324859-0yuhb5dl 212 3 COVID-19 covid-19 JJ cord-324859-0yuhb5dl 212 4 patients patient NNS cord-324859-0yuhb5dl 212 5 for for IN cord-324859-0yuhb5dl 212 6 hyperinflammatory hyperinflammatory NNP cord-324859-0yuhb5dl 212 7 state state NN cord-324859-0yuhb5dl 212 8 using use VBG cord-324859-0yuhb5dl 212 9 laboratory laboratory NN cord-324859-0yuhb5dl 212 10 trends trend NNS cord-324859-0yuhb5dl 212 11 and and CC cord-324859-0yuhb5dl 212 12 severity severity NN cord-324859-0yuhb5dl 212 13 grading grading NN cord-324859-0yuhb5dl 212 14 systems system NNS cord-324859-0yuhb5dl 212 15 such such JJ cord-324859-0yuhb5dl 212 16 as as IN cord-324859-0yuhb5dl 212 17 HScore HScore NNP cord-324859-0yuhb5dl 212 18 , , , cord-324859-0yuhb5dl 212 19 devised devise VBN cord-324859-0yuhb5dl 212 20 originally originally RB cord-324859-0yuhb5dl 212 21 for for IN cord-324859-0yuhb5dl 212 22 secondary secondary JJ cord-324859-0yuhb5dl 212 23 haemophagocytic haemophagocytic JJ cord-324859-0yuhb5dl 212 24 lymphohistiocytosis lymphohistiocytosis NNP cord-324859-0yuhb5dl 212 25 ( ( -LRB- cord-324859-0yuhb5dl 212 26 sHLH sHLH NNP cord-324859-0yuhb5dl 212 27 ) ) -RRB- cord-324859-0yuhb5dl 212 28 , , , cord-324859-0yuhb5dl 212 29 can can MD cord-324859-0yuhb5dl 212 30 be be VB cord-324859-0yuhb5dl 212 31 useful useful JJ cord-324859-0yuhb5dl 212 32 in in IN cord-324859-0yuhb5dl 212 33 identifying identify VBG cord-324859-0yuhb5dl 212 34 ideal ideal JJ cord-324859-0yuhb5dl 212 35 candidates candidate NNS cord-324859-0yuhb5dl 212 36 for for IN cord-324859-0yuhb5dl 212 37 immunosuppressive immunosuppressive JJ cord-324859-0yuhb5dl 212 38 therapies therapy NNS cord-324859-0yuhb5dl 212 39 . . . cord-324859-0yuhb5dl 213 1 85 85 CD cord-324859-0yuhb5dl 213 2 Currently currently RB cord-324859-0yuhb5dl 213 3 , , , cord-324859-0yuhb5dl 213 4 there there EX cord-324859-0yuhb5dl 213 5 is be VBZ cord-324859-0yuhb5dl 213 6 significant significant JJ cord-324859-0yuhb5dl 213 7 interest interest NN cord-324859-0yuhb5dl 213 8 in in IN cord-324859-0yuhb5dl 213 9 evaluating evaluate VBG cord-324859-0yuhb5dl 213 10 the the DT cord-324859-0yuhb5dl 213 11 efficacy efficacy NN cord-324859-0yuhb5dl 213 12 and and CC cord-324859-0yuhb5dl 213 13 safety safety NN cord-324859-0yuhb5dl 213 14 of of IN cord-324859-0yuhb5dl 213 15 tocilizumab tocilizumab NNP cord-324859-0yuhb5dl 213 16 , , , cord-324859-0yuhb5dl 213 17 a a DT cord-324859-0yuhb5dl 213 18 humanized humanize VBN cord-324859-0yuhb5dl 213 19 monoclonal monoclonal JJ cord-324859-0yuhb5dl 213 20 antibody antibody NN cord-324859-0yuhb5dl 213 21 against against IN cord-324859-0yuhb5dl 213 22 IL-6 IL-6 NNP cord-324859-0yuhb5dl 213 23 , , , cord-324859-0yuhb5dl 213 24 in in IN cord-324859-0yuhb5dl 213 25 COVID-19 covid-19 JJ cord-324859-0yuhb5dl 213 26 patients patient NNS cord-324859-0yuhb5dl 213 27 as as IN cord-324859-0yuhb5dl 213 28 evidenced evidence VBN cord-324859-0yuhb5dl 213 29 by by IN cord-324859-0yuhb5dl 213 30 more more JJR cord-324859-0yuhb5dl 213 31 than than IN cord-324859-0yuhb5dl 213 32 50 50 CD cord-324859-0yuhb5dl 213 33 ongoing ongoing JJ cord-324859-0yuhb5dl 213 34 clinical clinical JJ cord-324859-0yuhb5dl 213 35 studies study NNS cord-324859-0yuhb5dl 213 36 across across IN cord-324859-0yuhb5dl 213 37 the the DT cord-324859-0yuhb5dl 213 38 globe globe NN cord-324859-0yuhb5dl 213 39 . . . cord-324859-0yuhb5dl 214 1 86 86 CD cord-324859-0yuhb5dl 215 1 The the DT cord-324859-0yuhb5dl 215 2 drug drug NN cord-324859-0yuhb5dl 215 3 is be VBZ cord-324859-0yuhb5dl 215 4 currently currently RB cord-324859-0yuhb5dl 215 5 approved approve VBN cord-324859-0yuhb5dl 215 6 for for IN cord-324859-0yuhb5dl 215 7 rheumatoid rheumatoid NN cord-324859-0yuhb5dl 215 8 arthritis arthritis NN cord-324859-0yuhb5dl 215 9 , , , cord-324859-0yuhb5dl 215 10 giant giant JJ cord-324859-0yuhb5dl 215 11 cell cell NN cord-324859-0yuhb5dl 215 12 arteritis arteritis NN cord-324859-0yuhb5dl 215 13 and and CC cord-324859-0yuhb5dl 215 14 cytokine cytokine NN cord-324859-0yuhb5dl 215 15 release release NN cord-324859-0yuhb5dl 215 16 syndrome syndrome NN cord-324859-0yuhb5dl 215 17 as as RB cord-324859-0yuhb5dl 215 18 well well RB cord-324859-0yuhb5dl 215 19 as as IN cord-324859-0yuhb5dl 215 20 used use VBN cord-324859-0yuhb5dl 215 21 off off IN cord-324859-0yuhb5dl 215 22 - - HYPH cord-324859-0yuhb5dl 215 23 label label NN cord-324859-0yuhb5dl 215 24 for for IN cord-324859-0yuhb5dl 215 25 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 215 26 as as IN cord-324859-0yuhb5dl 215 27 an an DT cord-324859-0yuhb5dl 215 28 investigational investigational JJ cord-324859-0yuhb5dl 215 29 agent agent NN cord-324859-0yuhb5dl 215 30 . . . cord-324859-0yuhb5dl 216 1 However however RB cord-324859-0yuhb5dl 216 2 , , , cord-324859-0yuhb5dl 216 3 the the DT cord-324859-0yuhb5dl 216 4 timing timing NN cord-324859-0yuhb5dl 216 5 of of IN cord-324859-0yuhb5dl 216 6 the the DT cord-324859-0yuhb5dl 216 7 IL-6 IL-6 NNP cord-324859-0yuhb5dl 216 8 blocking block VBG cord-324859-0yuhb5dl 216 9 therapy therapy NN cord-324859-0yuhb5dl 216 10 in in IN cord-324859-0yuhb5dl 216 11 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 216 12 patients patient NNS cord-324859-0yuhb5dl 216 13 appears appear VBZ cord-324859-0yuhb5dl 216 14 to to TO cord-324859-0yuhb5dl 216 15 be be VB cord-324859-0yuhb5dl 216 16 crucial crucial JJ cord-324859-0yuhb5dl 216 17 since since IN cord-324859-0yuhb5dl 216 18 preclinical preclinical JJ cord-324859-0yuhb5dl 216 19 studies study NNS cord-324859-0yuhb5dl 216 20 have have VBP cord-324859-0yuhb5dl 216 21 demonstrated demonstrate VBN cord-324859-0yuhb5dl 216 22 that that IN cord-324859-0yuhb5dl 216 23 IL-6 IL-6 NNP cord-324859-0yuhb5dl 216 24 is be VBZ cord-324859-0yuhb5dl 216 25 required require VBN cord-324859-0yuhb5dl 216 26 for for IN cord-324859-0yuhb5dl 216 27 viral viral JJ cord-324859-0yuhb5dl 216 28 clearance clearance NN cord-324859-0yuhb5dl 216 29 as as RB cord-324859-0yuhb5dl 216 30 well well RB cord-324859-0yuhb5dl 216 31 as as IN cord-324859-0yuhb5dl 216 32 control control NN cord-324859-0yuhb5dl 216 33 of of IN cord-324859-0yuhb5dl 216 34 lung lung NN cord-324859-0yuhb5dl 216 35 inflammation inflammation NN cord-324859-0yuhb5dl 216 36 . . . cord-324859-0yuhb5dl 217 1 87 87 CD cord-324859-0yuhb5dl 218 1 On on IN cord-324859-0yuhb5dl 218 2 the the DT cord-324859-0yuhb5dl 218 3 contrary contrary JJ cord-324859-0yuhb5dl 218 4 , , , cord-324859-0yuhb5dl 218 5 high high JJ cord-324859-0yuhb5dl 218 6 levels level NNS cord-324859-0yuhb5dl 218 7 of of IN cord-324859-0yuhb5dl 218 8 IL-6 IL-6 NNP cord-324859-0yuhb5dl 218 9 may may MD cord-324859-0yuhb5dl 218 10 also also RB cord-324859-0yuhb5dl 218 11 promote promote VB cord-324859-0yuhb5dl 218 12 viral viral JJ cord-324859-0yuhb5dl 218 13 persistence persistence NN cord-324859-0yuhb5dl 218 14 through through IN cord-324859-0yuhb5dl 218 15 suppression suppression NN cord-324859-0yuhb5dl 218 16 of of IN cord-324859-0yuhb5dl 218 17 T t NN cord-324859-0yuhb5dl 218 18 - - HYPH cord-324859-0yuhb5dl 218 19 cell cell NN cord-324859-0yuhb5dl 218 20 cytolytic cytolytic JJ cord-324859-0yuhb5dl 218 21 activity activity NN cord-324859-0yuhb5dl 218 22 . . . cord-324859-0yuhb5dl 219 1 88 88 CD cord-324859-0yuhb5dl 219 2 , , , cord-324859-0yuhb5dl 219 3 89 89 CD cord-324859-0yuhb5dl 220 1 This this DT cord-324859-0yuhb5dl 220 2 dilemma dilemma NN cord-324859-0yuhb5dl 220 3 needs need VBZ cord-324859-0yuhb5dl 220 4 to to TO cord-324859-0yuhb5dl 220 5 be be VB cord-324859-0yuhb5dl 220 6 resolved resolve VBN cord-324859-0yuhb5dl 220 7 through through IN cord-324859-0yuhb5dl 220 8 clinical clinical JJ cord-324859-0yuhb5dl 220 9 trials trial NNS cord-324859-0yuhb5dl 220 10 aimed aim VBN cord-324859-0yuhb5dl 220 11 to to TO cord-324859-0yuhb5dl 220 12 determine determine VB cord-324859-0yuhb5dl 220 13 whether whether IN cord-324859-0yuhb5dl 220 14 early early JJ cord-324859-0yuhb5dl 220 15 IL-6R IL-6R NNP cord-324859-0yuhb5dl 220 16 blockade blockade NN cord-324859-0yuhb5dl 220 17 hampers hamper NNS cord-324859-0yuhb5dl 220 18 viral viral JJ cord-324859-0yuhb5dl 220 19 clearance clearance NN cord-324859-0yuhb5dl 220 20 . . . cord-324859-0yuhb5dl 221 1 Based base VBN cord-324859-0yuhb5dl 221 2 on on IN cord-324859-0yuhb5dl 221 3 the the DT cord-324859-0yuhb5dl 221 4 available available JJ cord-324859-0yuhb5dl 221 5 evidence evidence NN cord-324859-0yuhb5dl 221 6 , , , cord-324859-0yuhb5dl 221 7 management management NN cord-324859-0yuhb5dl 221 8 of of IN cord-324859-0yuhb5dl 221 9 early early JJ cord-324859-0yuhb5dl 221 10 stages stage NNS cord-324859-0yuhb5dl 221 11 of of IN cord-324859-0yuhb5dl 221 12 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 221 13 should should MD cord-324859-0yuhb5dl 221 14 focus focus VB cord-324859-0yuhb5dl 221 15 on on IN cord-324859-0yuhb5dl 221 16 antiviral antiviral JJ cord-324859-0yuhb5dl 221 17 approaches approach NNS cord-324859-0yuhb5dl 221 18 and/or and/or CC cord-324859-0yuhb5dl 221 19 augmentation augmentation NN cord-324859-0yuhb5dl 221 20 of of IN cord-324859-0yuhb5dl 221 21 IFN IFN NNP cord-324859-0yuhb5dl 221 22 type type NN cord-324859-0yuhb5dl 221 23 I -PRON- PRP cord-324859-0yuhb5dl 221 24 response response NN cord-324859-0yuhb5dl 221 25 . . . cord-324859-0yuhb5dl 222 1 Remdesivir Remdesivir NNP cord-324859-0yuhb5dl 222 2 , , , cord-324859-0yuhb5dl 222 3 an an DT cord-324859-0yuhb5dl 222 4 antiviral antiviral JJ cord-324859-0yuhb5dl 222 5 prodrug prodrug NN cord-324859-0yuhb5dl 222 6 , , , cord-324859-0yuhb5dl 222 7 has have VBZ cord-324859-0yuhb5dl 222 8 recently recently RB cord-324859-0yuhb5dl 222 9 shown show VBN cord-324859-0yuhb5dl 222 10 some some DT cord-324859-0yuhb5dl 222 11 benefit benefit NN cord-324859-0yuhb5dl 222 12 in in IN cord-324859-0yuhb5dl 222 13 patients patient NNS cord-324859-0yuhb5dl 222 14 with with IN cord-324859-0yuhb5dl 222 15 moderate moderate JJ cord-324859-0yuhb5dl 222 16 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 222 17 , , , cord-324859-0yuhb5dl 222 18 indicating indicate VBG cord-324859-0yuhb5dl 222 19 that that IN cord-324859-0yuhb5dl 222 20 targeting target VBG cord-324859-0yuhb5dl 222 21 early early JJ cord-324859-0yuhb5dl 222 22 stages stage NNS cord-324859-0yuhb5dl 222 23 of of IN cord-324859-0yuhb5dl 222 24 the the DT cord-324859-0yuhb5dl 222 25 illness illness NN cord-324859-0yuhb5dl 222 26 and and CC cord-324859-0yuhb5dl 222 27 patients patient NNS cord-324859-0yuhb5dl 222 28 with with IN cord-324859-0yuhb5dl 222 29 moderate moderate JJ cord-324859-0yuhb5dl 222 30 disease disease NN cord-324859-0yuhb5dl 222 31 is be VBZ cord-324859-0yuhb5dl 222 32 perhaps perhaps RB cord-324859-0yuhb5dl 222 33 a a DT cord-324859-0yuhb5dl 222 34 more more RBR cord-324859-0yuhb5dl 222 35 rational rational JJ cord-324859-0yuhb5dl 222 36 approach approach NN cord-324859-0yuhb5dl 222 37 . . . cord-324859-0yuhb5dl 223 1 90 90 CD cord-324859-0yuhb5dl 223 2 Subsequently subsequently RB cord-324859-0yuhb5dl 223 3 , , , cord-324859-0yuhb5dl 223 4 in in IN cord-324859-0yuhb5dl 223 5 more more RBR cord-324859-0yuhb5dl 223 6 advanced advanced JJ cord-324859-0yuhb5dl 223 7 stages stage NNS cord-324859-0yuhb5dl 223 8 , , , cord-324859-0yuhb5dl 223 9 use use NN cord-324859-0yuhb5dl 223 10 of of IN cord-324859-0yuhb5dl 223 11 immunomodulation immunomodulation NN cord-324859-0yuhb5dl 223 12 strategies strategy NNS cord-324859-0yuhb5dl 223 13 to to TO cord-324859-0yuhb5dl 223 14 control control VB cord-324859-0yuhb5dl 223 15 the the DT cord-324859-0yuhb5dl 223 16 infection infection NN cord-324859-0yuhb5dl 223 17 - - HYPH cord-324859-0yuhb5dl 223 18 associated associate VBN cord-324859-0yuhb5dl 223 19 hyperinflammation hyperinflammation NN cord-324859-0yuhb5dl 223 20 could could MD cord-324859-0yuhb5dl 223 21 be be VB cord-324859-0yuhb5dl 223 22 critical critical JJ cord-324859-0yuhb5dl 223 23 in in IN cord-324859-0yuhb5dl 223 24 reducing reduce VBG cord-324859-0yuhb5dl 223 25 COVID-19-linked covid-19-linked JJ cord-324859-0yuhb5dl 223 26 mortality mortality NN cord-324859-0yuhb5dl 223 27 . . . cord-324859-0yuhb5dl 224 1 The the DT cord-324859-0yuhb5dl 224 2 latter latter JJ cord-324859-0yuhb5dl 224 3 is be VBZ cord-324859-0yuhb5dl 224 4 also also RB cord-324859-0yuhb5dl 224 5 supported support VBN cord-324859-0yuhb5dl 224 6 by by IN cord-324859-0yuhb5dl 224 7 the the DT cord-324859-0yuhb5dl 224 8 findings finding NNS cord-324859-0yuhb5dl 224 9 from from IN cord-324859-0yuhb5dl 224 10 SARS SARS NNP cord-324859-0yuhb5dl 224 11 patients patient NNS cord-324859-0yuhb5dl 224 12 , , , cord-324859-0yuhb5dl 224 13 where where WRB cord-324859-0yuhb5dl 224 14 ARDS ARDS NNP cord-324859-0yuhb5dl 224 15 occurs occur VBZ cord-324859-0yuhb5dl 224 16 despite despite IN cord-324859-0yuhb5dl 224 17 declining decline VBG cord-324859-0yuhb5dl 224 18 viral viral JJ cord-324859-0yuhb5dl 224 19 loads load NNS cord-324859-0yuhb5dl 224 20 , , , cord-324859-0yuhb5dl 224 21 suggesting suggest VBG cord-324859-0yuhb5dl 224 22 the the DT cord-324859-0yuhb5dl 224 23 role role NN cord-324859-0yuhb5dl 224 24 of of IN cord-324859-0yuhb5dl 224 25 hyperinflammation hyperinflammation NN cord-324859-0yuhb5dl 224 26 rather rather RB cord-324859-0yuhb5dl 224 27 than than IN cord-324859-0yuhb5dl 224 28 pathogen pathogen NN cord-324859-0yuhb5dl 224 29 virulence virulence NN cord-324859-0yuhb5dl 224 30 in in IN cord-324859-0yuhb5dl 224 31 determining determine VBG cord-324859-0yuhb5dl 224 32 adverse adverse JJ cord-324859-0yuhb5dl 224 33 patient patient JJ cord-324859-0yuhb5dl 224 34 outcomes outcome NNS cord-324859-0yuhb5dl 224 35 . . . cord-324859-0yuhb5dl 225 1 91 91 CD cord-324859-0yuhb5dl 226 1 The the DT cord-324859-0yuhb5dl 226 2 recent recent JJ cord-324859-0yuhb5dl 226 3 findings finding NNS cord-324859-0yuhb5dl 226 4 from from IN cord-324859-0yuhb5dl 226 5 the the DT cord-324859-0yuhb5dl 226 6 RECOVERY recovery NN cord-324859-0yuhb5dl 226 7 ( ( -LRB- cord-324859-0yuhb5dl 226 8 Randomised Randomised NNP cord-324859-0yuhb5dl 226 9 Evaluation Evaluation NNP cord-324859-0yuhb5dl 226 10 of of IN cord-324859-0yuhb5dl 226 11 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 226 12 thER thER NNP cord-324859-0yuhb5dl 226 13 - - HYPH cord-324859-0yuhb5dl 226 14 apY apY NNP cord-324859-0yuhb5dl 226 15 ) ) -RRB- cord-324859-0yuhb5dl 226 16 trial trial NN cord-324859-0yuhb5dl 226 17 , , , cord-324859-0yuhb5dl 226 18 where where WRB cord-324859-0yuhb5dl 226 19 low low JJ cord-324859-0yuhb5dl 226 20 - - HYPH cord-324859-0yuhb5dl 226 21 dose dose NN cord-324859-0yuhb5dl 226 22 dexamethasone dexamethasone NN cord-324859-0yuhb5dl 226 23 reduced reduce VBN cord-324859-0yuhb5dl 226 24 mortality mortality NN cord-324859-0yuhb5dl 226 25 by by IN cord-324859-0yuhb5dl 226 26 one one CD cord-324859-0yuhb5dl 226 27 - - HYPH cord-324859-0yuhb5dl 226 28 third third NN cord-324859-0yuhb5dl 226 29 in in IN cord-324859-0yuhb5dl 226 30 mechanically mechanically RB cord-324859-0yuhb5dl 226 31 ventilated ventilate VBN cord-324859-0yuhb5dl 226 32 and and CC cord-324859-0yuhb5dl 226 33 one one CD cord-324859-0yuhb5dl 226 34 - - HYPH cord-324859-0yuhb5dl 226 35 fifth fifth NN cord-324859-0yuhb5dl 226 36 in in IN cord-324859-0yuhb5dl 226 37 oxygen oxygen NN cord-324859-0yuhb5dl 226 38 - - HYPH cord-324859-0yuhb5dl 226 39 requiring require VBG cord-324859-0yuhb5dl 226 40 patients patient NNS cord-324859-0yuhb5dl 226 41 , , , cord-324859-0yuhb5dl 226 42 are be VBP cord-324859-0yuhb5dl 226 43 in in IN cord-324859-0yuhb5dl 226 44 consonance consonance NN cord-324859-0yuhb5dl 226 45 with with IN cord-324859-0yuhb5dl 226 46 this this DT cord-324859-0yuhb5dl 226 47 approach approach NN cord-324859-0yuhb5dl 226 48 . . . cord-324859-0yuhb5dl 227 1 The the DT cord-324859-0yuhb5dl 227 2 trial trial NN cord-324859-0yuhb5dl 227 3 enrolled enrol VBD cord-324859-0yuhb5dl 227 4 more more JJR cord-324859-0yuhb5dl 227 5 than than IN cord-324859-0yuhb5dl 227 6 6000 6000 CD cord-324859-0yuhb5dl 227 7 patients patient NNS cord-324859-0yuhb5dl 227 8 , , , cord-324859-0yuhb5dl 227 9 and and CC cord-324859-0yuhb5dl 227 10 evidently evidently RB cord-324859-0yuhb5dl 227 11 , , , cord-324859-0yuhb5dl 227 12 no no DT cord-324859-0yuhb5dl 227 13 mortality mortality NN cord-324859-0yuhb5dl 227 14 benefit benefit NN cord-324859-0yuhb5dl 227 15 was be VBD cord-324859-0yuhb5dl 227 16 observed observe VBN cord-324859-0yuhb5dl 227 17 in in IN cord-324859-0yuhb5dl 227 18 individuals individual NNS cord-324859-0yuhb5dl 227 19 not not RB cord-324859-0yuhb5dl 227 20 requiring require VBG cord-324859-0yuhb5dl 227 21 respiratory respiratory JJ cord-324859-0yuhb5dl 227 22 support support NN cord-324859-0yuhb5dl 227 23 at at IN cord-324859-0yuhb5dl 227 24 randomization randomization NN cord-324859-0yuhb5dl 227 25 . . . cord-324859-0yuhb5dl 228 1 92 92 CD cord-324859-0yuhb5dl 229 1 However however RB cord-324859-0yuhb5dl 229 2 , , , cord-324859-0yuhb5dl 229 3 our -PRON- PRP$ cord-324859-0yuhb5dl 229 4 review review NN cord-324859-0yuhb5dl 229 5 findings finding NNS cord-324859-0yuhb5dl 229 6 need need VBP cord-324859-0yuhb5dl 229 7 to to TO cord-324859-0yuhb5dl 229 8 be be VB cord-324859-0yuhb5dl 229 9 interpreted interpret VBN cord-324859-0yuhb5dl 229 10 with with IN cord-324859-0yuhb5dl 229 11 caution caution NN cord-324859-0yuhb5dl 229 12 , , , cord-324859-0yuhb5dl 229 13 owing owe VBG cord-324859-0yuhb5dl 229 14 to to IN cord-324859-0yuhb5dl 229 15 the the DT cord-324859-0yuhb5dl 229 16 high high JJ cord-324859-0yuhb5dl 229 17 heterogeneity heterogeneity NN cord-324859-0yuhb5dl 229 18 among among IN cord-324859-0yuhb5dl 229 19 studies study NNS cord-324859-0yuhb5dl 229 20 reporting report VBG cord-324859-0yuhb5dl 229 21 inflammatory inflammatory JJ cord-324859-0yuhb5dl 229 22 markers marker NNS cord-324859-0yuhb5dl 229 23 . . . cord-324859-0yuhb5dl 230 1 Several several JJ cord-324859-0yuhb5dl 230 2 factors factor NNS cord-324859-0yuhb5dl 230 3 could could MD cord-324859-0yuhb5dl 230 4 be be VB cord-324859-0yuhb5dl 230 5 responsible responsible JJ cord-324859-0yuhb5dl 230 6 for for IN cord-324859-0yuhb5dl 230 7 this this DT cord-324859-0yuhb5dl 230 8 variation variation NN cord-324859-0yuhb5dl 230 9 in in IN cord-324859-0yuhb5dl 230 10 effect effect NN cord-324859-0yuhb5dl 230 11 estimates estimate NNS cord-324859-0yuhb5dl 230 12 in in IN cord-324859-0yuhb5dl 230 13 some some DT cord-324859-0yuhb5dl 230 14 of of IN cord-324859-0yuhb5dl 230 15 the the DT cord-324859-0yuhb5dl 230 16 outcomes outcome NNS cord-324859-0yuhb5dl 230 17 , , , cord-324859-0yuhb5dl 230 18 like like IN cord-324859-0yuhb5dl 230 19 variability variability NN cord-324859-0yuhb5dl 230 20 in in IN cord-324859-0yuhb5dl 230 21 sample sample NN cord-324859-0yuhb5dl 230 22 sizes size NNS cord-324859-0yuhb5dl 230 23 and and CC cord-324859-0yuhb5dl 230 24 non non JJ cord-324859-0yuhb5dl 230 25 - - JJ cord-324859-0yuhb5dl 230 26 uniform uniform JJ cord-324859-0yuhb5dl 230 27 distribution distribution NN cord-324859-0yuhb5dl 230 28 of of IN cord-324859-0yuhb5dl 230 29 patients patient NNS cord-324859-0yuhb5dl 230 30 in in IN cord-324859-0yuhb5dl 230 31 the the DT cord-324859-0yuhb5dl 230 32 severe severe JJ cord-324859-0yuhb5dl 230 33 and and CC cord-324859-0yuhb5dl 230 34 non non JJ cord-324859-0yuhb5dl 230 35 - - JJ cord-324859-0yuhb5dl 230 36 severe severe JJ cord-324859-0yuhb5dl 230 37 groups group NNS cord-324859-0yuhb5dl 230 38 . . . cord-324859-0yuhb5dl 231 1 Heterogeneity heterogeneity NN cord-324859-0yuhb5dl 231 2 might may MD cord-324859-0yuhb5dl 231 3 also also RB cord-324859-0yuhb5dl 231 4 be be VB cord-324859-0yuhb5dl 231 5 a a DT cord-324859-0yuhb5dl 231 6 consequence consequence NN cord-324859-0yuhb5dl 231 7 of of IN cord-324859-0yuhb5dl 231 8 weak weak JJ cord-324859-0yuhb5dl 231 9 study study NN cord-324859-0yuhb5dl 231 10 designs design NNS cord-324859-0yuhb5dl 231 11 and and CC cord-324859-0yuhb5dl 231 12 other other JJ cord-324859-0yuhb5dl 231 13 methodological methodological JJ cord-324859-0yuhb5dl 231 14 shortcomings shortcoming NNS cord-324859-0yuhb5dl 231 15 , , , cord-324859-0yuhb5dl 231 16 studies study NNS cord-324859-0yuhb5dl 231 17 employing employ VBG cord-324859-0yuhb5dl 231 18 varied varied JJ cord-324859-0yuhb5dl 231 19 cut cut NN cord-324859-0yuhb5dl 231 20 - - HYPH cord-324859-0yuhb5dl 231 21 offs off NNS cord-324859-0yuhb5dl 231 22 to to TO cord-324859-0yuhb5dl 231 23 categorize categorize VB cord-324859-0yuhb5dl 231 24 patients patient NNS cord-324859-0yuhb5dl 231 25 into into IN cord-324859-0yuhb5dl 231 26 disease disease NN cord-324859-0yuhb5dl 231 27 severity severity NN cord-324859-0yuhb5dl 231 28 groups group NNS cord-324859-0yuhb5dl 231 29 and and CC cord-324859-0yuhb5dl 231 30 differences difference NNS cord-324859-0yuhb5dl 231 31 in in IN cord-324859-0yuhb5dl 231 32 the the DT cord-324859-0yuhb5dl 231 33 underlying underlie VBG cord-324859-0yuhb5dl 231 34 comorbid comorbid NN cord-324859-0yuhb5dl 231 35 conditions condition NNS cord-324859-0yuhb5dl 231 36 , , , cord-324859-0yuhb5dl 231 37 as as RB cord-324859-0yuhb5dl 231 38 well well RB cord-324859-0yuhb5dl 231 39 as as IN cord-324859-0yuhb5dl 231 40 variability variability NN cord-324859-0yuhb5dl 231 41 in in IN cord-324859-0yuhb5dl 231 42 the the DT cord-324859-0yuhb5dl 231 43 timing timing NN cord-324859-0yuhb5dl 231 44 of of IN cord-324859-0yuhb5dl 231 45 measurement measurement NN cord-324859-0yuhb5dl 231 46 of of IN cord-324859-0yuhb5dl 231 47 the the DT cord-324859-0yuhb5dl 231 48 biomarkers biomarker NNS cord-324859-0yuhb5dl 231 49 . . . cord-324859-0yuhb5dl 232 1 However however RB cord-324859-0yuhb5dl 232 2 , , , cord-324859-0yuhb5dl 232 3 the the DT cord-324859-0yuhb5dl 232 4 fact fact NN cord-324859-0yuhb5dl 232 5 that that IN cord-324859-0yuhb5dl 232 6 the the DT cord-324859-0yuhb5dl 232 7 statistical statistical JJ cord-324859-0yuhb5dl 232 8 test test NN cord-324859-0yuhb5dl 232 9 for for IN cord-324859-0yuhb5dl 232 10 assessment assessment NN cord-324859-0yuhb5dl 232 11 of of IN cord-324859-0yuhb5dl 232 12 heterogeneity heterogeneity NN cord-324859-0yuhb5dl 232 13 is be VBZ cord-324859-0yuhb5dl 232 14 largely largely RB cord-324859-0yuhb5dl 232 15 underpowered underpowered JJ cord-324859-0yuhb5dl 232 16 in in IN cord-324859-0yuhb5dl 232 17 a a DT cord-324859-0yuhb5dl 232 18 meta meta JJ cord-324859-0yuhb5dl 232 19 - - HYPH cord-324859-0yuhb5dl 232 20 analysis analysis NN cord-324859-0yuhb5dl 232 21 22 22 CD cord-324859-0yuhb5dl 232 22 wherein wherein WRB cord-324859-0yuhb5dl 232 23 studies study NNS cord-324859-0yuhb5dl 232 24 are be VBP cord-324859-0yuhb5dl 232 25 either either CC cord-324859-0yuhb5dl 232 26 very very RB cord-324859-0yuhb5dl 232 27 few few JJ cord-324859-0yuhb5dl 232 28 in in IN cord-324859-0yuhb5dl 232 29 number number NN cord-324859-0yuhb5dl 232 30 or or CC cord-324859-0yuhb5dl 232 31 have have VB cord-324859-0yuhb5dl 232 32 small small JJ cord-324859-0yuhb5dl 232 33 sample sample NN cord-324859-0yuhb5dl 232 34 sizes size NNS cord-324859-0yuhb5dl 232 35 should should MD cord-324859-0yuhb5dl 232 36 also also RB cord-324859-0yuhb5dl 232 37 be be VB cord-324859-0yuhb5dl 232 38 taken take VBN cord-324859-0yuhb5dl 232 39 into into IN cord-324859-0yuhb5dl 232 40 consideration consideration NN cord-324859-0yuhb5dl 232 41 . . . cord-324859-0yuhb5dl 233 1 We -PRON- PRP cord-324859-0yuhb5dl 233 2 undertook undertake VBD cord-324859-0yuhb5dl 233 3 a a DT cord-324859-0yuhb5dl 233 4 sensitivity sensitivity NN cord-324859-0yuhb5dl 233 5 analysis analysis NN cord-324859-0yuhb5dl 233 6 with with IN cord-324859-0yuhb5dl 233 7 only only JJ cord-324859-0yuhb5dl 233 8 studies study NNS cord-324859-0yuhb5dl 233 9 that that WDT cord-324859-0yuhb5dl 233 10 were be VBD cord-324859-0yuhb5dl 233 11 peer peer NN cord-324859-0yuhb5dl 233 12 - - HYPH cord-324859-0yuhb5dl 233 13 reviewed review VBN cord-324859-0yuhb5dl 233 14 and and CC cord-324859-0yuhb5dl 233 15 published publish VBN cord-324859-0yuhb5dl 233 16 , , , cord-324859-0yuhb5dl 233 17 excluding exclude VBG cord-324859-0yuhb5dl 233 18 the the DT cord-324859-0yuhb5dl 233 19 preprints preprint NNS cord-324859-0yuhb5dl 233 20 , , , cord-324859-0yuhb5dl 233 21 and and CC cord-324859-0yuhb5dl 233 22 found find VBD cord-324859-0yuhb5dl 233 23 that that IN cord-324859-0yuhb5dl 233 24 there there EX cord-324859-0yuhb5dl 233 25 was be VBD cord-324859-0yuhb5dl 233 26 no no DT cord-324859-0yuhb5dl 233 27 major major JJ cord-324859-0yuhb5dl 233 28 change change NN cord-324859-0yuhb5dl 233 29 in in IN cord-324859-0yuhb5dl 233 30 the the DT cord-324859-0yuhb5dl 233 31 direction direction NN cord-324859-0yuhb5dl 233 32 and and CC cord-324859-0yuhb5dl 233 33 magnitude magnitude NN cord-324859-0yuhb5dl 233 34 of of IN cord-324859-0yuhb5dl 233 35 the the DT cord-324859-0yuhb5dl 233 36 effects effect NNS cord-324859-0yuhb5dl 233 37 . . . cord-324859-0yuhb5dl 234 1 This this DT cord-324859-0yuhb5dl 234 2 underscores underscore VBZ cord-324859-0yuhb5dl 234 3 the the DT cord-324859-0yuhb5dl 234 4 robustness robustness NN cord-324859-0yuhb5dl 234 5 and and CC cord-324859-0yuhb5dl 234 6 validity validity NN cord-324859-0yuhb5dl 234 7 of of IN cord-324859-0yuhb5dl 234 8 our -PRON- PRP$ cord-324859-0yuhb5dl 234 9 findings finding NNS cord-324859-0yuhb5dl 234 10 . . . cord-324859-0yuhb5dl 235 1 Our -PRON- PRP$ cord-324859-0yuhb5dl 235 2 results result NNS cord-324859-0yuhb5dl 235 3 for for IN cord-324859-0yuhb5dl 235 4 IL-6 IL-6 NNP cord-324859-0yuhb5dl 235 5 are be VBP cord-324859-0yuhb5dl 235 6 consistent consistent JJ cord-324859-0yuhb5dl 235 7 with with IN cord-324859-0yuhb5dl 235 8 the the DT cord-324859-0yuhb5dl 235 9 other other JJ cord-324859-0yuhb5dl 235 10 recently recently RB cord-324859-0yuhb5dl 235 11 published publish VBN cord-324859-0yuhb5dl 235 12 reviews review NNS cord-324859-0yuhb5dl 235 13 comparing compare VBG cord-324859-0yuhb5dl 235 14 IL-6 IL-6 NNP cord-324859-0yuhb5dl 235 15 levels level NNS cord-324859-0yuhb5dl 235 16 between between IN cord-324859-0yuhb5dl 235 17 severe severe JJ cord-324859-0yuhb5dl 235 18 and and CC cord-324859-0yuhb5dl 235 19 moderate moderate JJ cord-324859-0yuhb5dl 235 20 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 235 21 patients patient NNS cord-324859-0yuhb5dl 235 22 . . . cord-324859-0yuhb5dl 236 1 [ [ -LRB- cord-324859-0yuhb5dl 236 2 10 10 CD cord-324859-0yuhb5dl 236 3 ] ] -RRB- cord-324859-0yuhb5dl 236 4 [ [ -LRB- cord-324859-0yuhb5dl 236 5 11 11 CD cord-324859-0yuhb5dl 236 6 ] ] -RRB- cord-324859-0yuhb5dl 236 7 [ [ -LRB- cord-324859-0yuhb5dl 236 8 12 12 CD cord-324859-0yuhb5dl 236 9 ] ] -RRB- cord-324859-0yuhb5dl 237 1 Nonetheless nonetheless RB cord-324859-0yuhb5dl 237 2 , , , cord-324859-0yuhb5dl 237 3 there there EX cord-324859-0yuhb5dl 237 4 is be VBZ cord-324859-0yuhb5dl 237 5 a a DT cord-324859-0yuhb5dl 237 6 need need NN cord-324859-0yuhb5dl 237 7 for for IN cord-324859-0yuhb5dl 237 8 further further JJ cord-324859-0yuhb5dl 237 9 high high JJ cord-324859-0yuhb5dl 237 10 - - HYPH cord-324859-0yuhb5dl 237 11 quality quality NN cord-324859-0yuhb5dl 237 12 prospective prospective JJ cord-324859-0yuhb5dl 237 13 studies study NNS cord-324859-0yuhb5dl 237 14 to to TO cord-324859-0yuhb5dl 237 15 contribute contribute VB cord-324859-0yuhb5dl 237 16 to to IN cord-324859-0yuhb5dl 237 17 the the DT cord-324859-0yuhb5dl 237 18 existing exist VBG cord-324859-0yuhb5dl 237 19 knowledge knowledge NN cord-324859-0yuhb5dl 237 20 , , , cord-324859-0yuhb5dl 237 21 enabling enable VBG cord-324859-0yuhb5dl 237 22 researchers researcher NNS cord-324859-0yuhb5dl 237 23 to to TO cord-324859-0yuhb5dl 237 24 better better RB cord-324859-0yuhb5dl 237 25 understand understand VB cord-324859-0yuhb5dl 237 26 the the DT cord-324859-0yuhb5dl 237 27 immunopathology immunopathology NN cord-324859-0yuhb5dl 237 28 of of IN cord-324859-0yuhb5dl 237 29 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 237 30 . . . cord-324859-0yuhb5dl 238 1 To to IN cord-324859-0yuhb5dl 238 2 the the DT cord-324859-0yuhb5dl 238 3 best good JJS cord-324859-0yuhb5dl 238 4 of of IN cord-324859-0yuhb5dl 238 5 our -PRON- PRP$ cord-324859-0yuhb5dl 238 6 knowledge knowledge NN cord-324859-0yuhb5dl 238 7 , , , cord-324859-0yuhb5dl 238 8 ours -PRON- PRP cord-324859-0yuhb5dl 238 9 is be VBZ cord-324859-0yuhb5dl 238 10 the the DT cord-324859-0yuhb5dl 238 11 first first JJ cord-324859-0yuhb5dl 238 12 systematic systematic JJ cord-324859-0yuhb5dl 238 13 review review NN cord-324859-0yuhb5dl 238 14 and and CC cord-324859-0yuhb5dl 238 15 meta meta NNP cord-324859-0yuhb5dl 238 16 - - HYPH cord-324859-0yuhb5dl 238 17 analysis analysis NN cord-324859-0yuhb5dl 238 18 to to TO cord-324859-0yuhb5dl 238 19 provide provide VB cord-324859-0yuhb5dl 238 20 a a DT cord-324859-0yuhb5dl 238 21 detailed detailed JJ cord-324859-0yuhb5dl 238 22 overview overview NN cord-324859-0yuhb5dl 238 23 of of IN cord-324859-0yuhb5dl 238 24 the the DT cord-324859-0yuhb5dl 238 25 immunological immunological JJ cord-324859-0yuhb5dl 238 26 and and CC cord-324859-0yuhb5dl 238 27 inflammatory inflammatory JJ cord-324859-0yuhb5dl 238 28 response response NN cord-324859-0yuhb5dl 238 29 in in IN cord-324859-0yuhb5dl 238 30 severe severe JJ cord-324859-0yuhb5dl 238 31 and and CC cord-324859-0yuhb5dl 238 32 non non JJ cord-324859-0yuhb5dl 238 33 - - JJ cord-324859-0yuhb5dl 238 34 severe severe JJ cord-324859-0yuhb5dl 238 35 patients patient NNS cord-324859-0yuhb5dl 238 36 of of IN cord-324859-0yuhb5dl 238 37 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 238 38 and and CC cord-324859-0yuhb5dl 238 39 quantify quantify VB cord-324859-0yuhb5dl 238 40 the the DT cord-324859-0yuhb5dl 238 41 difference difference NN cord-324859-0yuhb5dl 238 42 in in IN cord-324859-0yuhb5dl 238 43 various various JJ cord-324859-0yuhb5dl 238 44 outcomes outcome NNS cord-324859-0yuhb5dl 238 45 between between IN cord-324859-0yuhb5dl 238 46 the the DT cord-324859-0yuhb5dl 238 47 two two CD cord-324859-0yuhb5dl 238 48 groups group NNS cord-324859-0yuhb5dl 238 49 studied study VBD cord-324859-0yuhb5dl 238 50 . . . cord-324859-0yuhb5dl 239 1 Secondly secondly RB cord-324859-0yuhb5dl 239 2 , , , cord-324859-0yuhb5dl 239 3 a a DT cord-324859-0yuhb5dl 239 4 few few JJ cord-324859-0yuhb5dl 239 5 previous previous JJ cord-324859-0yuhb5dl 239 6 reviews review NNS cord-324859-0yuhb5dl 239 7 have have VBP cord-324859-0yuhb5dl 239 8 primarily primarily RB cord-324859-0yuhb5dl 239 9 focused focus VBN cord-324859-0yuhb5dl 239 10 on on IN cord-324859-0yuhb5dl 239 11 the the DT cord-324859-0yuhb5dl 239 12 comparison comparison NN cord-324859-0yuhb5dl 239 13 of of IN cord-324859-0yuhb5dl 239 14 IL-6 IL-6 NNP cord-324859-0yuhb5dl 239 15 levels level NNS cord-324859-0yuhb5dl 239 16 between between IN cord-324859-0yuhb5dl 239 17 COVID-19 covid-19 JJ cord-324859-0yuhb5dl 239 18 patients patient NNS cord-324859-0yuhb5dl 239 19 of of IN cord-324859-0yuhb5dl 239 20 varying vary VBG cord-324859-0yuhb5dl 239 21 disease disease NN cord-324859-0yuhb5dl 239 22 severity severity NN cord-324859-0yuhb5dl 239 23 , , , cord-324859-0yuhb5dl 239 24 and and CC cord-324859-0yuhb5dl 239 25 our -PRON- PRP$ cord-324859-0yuhb5dl 239 26 work work NN cord-324859-0yuhb5dl 239 27 provides provide VBZ cord-324859-0yuhb5dl 239 28 updated update VBN cord-324859-0yuhb5dl 239 29 evidence evidence NN cord-324859-0yuhb5dl 239 30 on on IN cord-324859-0yuhb5dl 239 31 the the DT cord-324859-0yuhb5dl 239 32 same same JJ cord-324859-0yuhb5dl 239 33 , , , cord-324859-0yuhb5dl 239 34 while while IN cord-324859-0yuhb5dl 239 35 exploring explore VBG cord-324859-0yuhb5dl 239 36 not not RB cord-324859-0yuhb5dl 239 37 just just RB cord-324859-0yuhb5dl 239 38 IL-6 IL-6 NNP cord-324859-0yuhb5dl 239 39 but but CC cord-324859-0yuhb5dl 239 40 other other JJ cord-324859-0yuhb5dl 239 41 markers marker NNS cord-324859-0yuhb5dl 239 42 as as RB cord-324859-0yuhb5dl 239 43 well well RB cord-324859-0yuhb5dl 239 44 . . . cord-324859-0yuhb5dl 240 1 Thirdly thirdly RB cord-324859-0yuhb5dl 240 2 , , , cord-324859-0yuhb5dl 240 3 considering consider VBG cord-324859-0yuhb5dl 240 4 that that IN cord-324859-0yuhb5dl 240 5 we -PRON- PRP cord-324859-0yuhb5dl 240 6 have have VBP cord-324859-0yuhb5dl 240 7 enormous enormous JJ cord-324859-0yuhb5dl 240 8 literature literature NN cord-324859-0yuhb5dl 240 9 being be VBG cord-324859-0yuhb5dl 240 10 rapidly rapidly RB cord-324859-0yuhb5dl 240 11 published publish VBN cord-324859-0yuhb5dl 240 12 , , , cord-324859-0yuhb5dl 240 13 we -PRON- PRP cord-324859-0yuhb5dl 240 14 covered cover VBD cord-324859-0yuhb5dl 240 15 7 7 CD cord-324859-0yuhb5dl 240 16 distinct distinct JJ cord-324859-0yuhb5dl 240 17 databases database NNS cord-324859-0yuhb5dl 240 18 and and CC cord-324859-0yuhb5dl 240 19 used use VBD cord-324859-0yuhb5dl 240 20 a a DT cord-324859-0yuhb5dl 240 21 sensitive sensitive JJ cord-324859-0yuhb5dl 240 22 search search NN cord-324859-0yuhb5dl 240 23 strategy strategy NN cord-324859-0yuhb5dl 240 24 to to TO cord-324859-0yuhb5dl 240 25 obtain obtain VB cord-324859-0yuhb5dl 240 26 as as RB cord-324859-0yuhb5dl 240 27 many many JJ cord-324859-0yuhb5dl 240 28 relevant relevant JJ cord-324859-0yuhb5dl 240 29 studies study NNS cord-324859-0yuhb5dl 240 30 as as IN cord-324859-0yuhb5dl 240 31 possible possible JJ cord-324859-0yuhb5dl 240 32 . . . cord-324859-0yuhb5dl 241 1 Our -PRON- PRP$ cord-324859-0yuhb5dl 241 2 review review NN cord-324859-0yuhb5dl 241 3 has have VBZ cord-324859-0yuhb5dl 241 4 a a DT cord-324859-0yuhb5dl 241 5 few few JJ cord-324859-0yuhb5dl 241 6 limitations limitation NNS cord-324859-0yuhb5dl 241 7 . . . cord-324859-0yuhb5dl 242 1 Some some DT cord-324859-0yuhb5dl 242 2 studies study NNS cord-324859-0yuhb5dl 242 3 had have VBD cord-324859-0yuhb5dl 242 4 not not RB cord-324859-0yuhb5dl 242 5 provided provide VBN cord-324859-0yuhb5dl 242 6 the the DT cord-324859-0yuhb5dl 242 7 necessary necessary JJ cord-324859-0yuhb5dl 242 8 information information NN cord-324859-0yuhb5dl 242 9 on on IN cord-324859-0yuhb5dl 242 10 their -PRON- PRP$ cord-324859-0yuhb5dl 242 11 methodological methodological JJ cord-324859-0yuhb5dl 242 12 aspects aspect NNS cord-324859-0yuhb5dl 242 13 which which WDT cord-324859-0yuhb5dl 242 14 may may MD cord-324859-0yuhb5dl 242 15 have have VB cord-324859-0yuhb5dl 242 16 led lead VBN cord-324859-0yuhb5dl 242 17 to to IN cord-324859-0yuhb5dl 242 18 a a DT cord-324859-0yuhb5dl 242 19 possible possible JJ cord-324859-0yuhb5dl 242 20 underestimation underestimation NN cord-324859-0yuhb5dl 242 21 of of IN cord-324859-0yuhb5dl 242 22 their -PRON- PRP$ cord-324859-0yuhb5dl 242 23 quality quality NN cord-324859-0yuhb5dl 242 24 . . . cord-324859-0yuhb5dl 243 1 Also also RB cord-324859-0yuhb5dl 243 2 , , , cord-324859-0yuhb5dl 243 3 authors author NNS cord-324859-0yuhb5dl 243 4 were be VBD cord-324859-0yuhb5dl 243 5 contacted contact VBN cord-324859-0yuhb5dl 243 6 regarding regard VBG cord-324859-0yuhb5dl 243 7 a a DT cord-324859-0yuhb5dl 243 8 possible possible JJ cord-324859-0yuhb5dl 243 9 overlap overlap NN cord-324859-0yuhb5dl 243 10 of of IN cord-324859-0yuhb5dl 243 11 participants participant NNS cord-324859-0yuhb5dl 243 12 in in IN cord-324859-0yuhb5dl 243 13 some some DT cord-324859-0yuhb5dl 243 14 studies study NNS cord-324859-0yuhb5dl 243 15 conducted conduct VBN cord-324859-0yuhb5dl 243 16 at at IN cord-324859-0yuhb5dl 243 17 a a DT cord-324859-0yuhb5dl 243 18 common common JJ cord-324859-0yuhb5dl 243 19 hospital hospital NN cord-324859-0yuhb5dl 243 20 , , , cord-324859-0yuhb5dl 243 21 but but CC cord-324859-0yuhb5dl 243 22 a a DT cord-324859-0yuhb5dl 243 23 majority majority NN cord-324859-0yuhb5dl 243 24 ( ( -LRB- cord-324859-0yuhb5dl 243 25 95 95 CD cord-324859-0yuhb5dl 243 26 % % NN cord-324859-0yuhb5dl 243 27 ) ) -RRB- cord-324859-0yuhb5dl 243 28 of of IN cord-324859-0yuhb5dl 243 29 them -PRON- PRP cord-324859-0yuhb5dl 243 30 did do VBD cord-324859-0yuhb5dl 243 31 not not RB cord-324859-0yuhb5dl 243 32 respond respond VB cord-324859-0yuhb5dl 243 33 to to IN cord-324859-0yuhb5dl 243 34 our -PRON- PRP$ cord-324859-0yuhb5dl 243 35 queries query NNS cord-324859-0yuhb5dl 243 36 . . . cord-324859-0yuhb5dl 244 1 In in IN cord-324859-0yuhb5dl 244 2 addition addition NN cord-324859-0yuhb5dl 244 3 , , , cord-324859-0yuhb5dl 244 4 our -PRON- PRP$ cord-324859-0yuhb5dl 244 5 analyses analysis NNS cord-324859-0yuhb5dl 244 6 of of IN cord-324859-0yuhb5dl 244 7 immune immune JJ cord-324859-0yuhb5dl 244 8 responses response NNS cord-324859-0yuhb5dl 244 9 in in IN cord-324859-0yuhb5dl 244 10 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 244 11 were be VBD cord-324859-0yuhb5dl 244 12 limited limit VBN cord-324859-0yuhb5dl 244 13 by by IN cord-324859-0yuhb5dl 244 14 findings finding NNS cord-324859-0yuhb5dl 244 15 reported report VBN cord-324859-0yuhb5dl 244 16 by by IN cord-324859-0yuhb5dl 244 17 individual individual JJ cord-324859-0yuhb5dl 244 18 studies study NNS cord-324859-0yuhb5dl 244 19 and and CC cord-324859-0yuhb5dl 244 20 we -PRON- PRP cord-324859-0yuhb5dl 244 21 could could MD cord-324859-0yuhb5dl 244 22 not not RB cord-324859-0yuhb5dl 244 23 evaluate evaluate VB cord-324859-0yuhb5dl 244 24 the the DT cord-324859-0yuhb5dl 244 25 entire entire JJ cord-324859-0yuhb5dl 244 26 spectrum spectrum NN cord-324859-0yuhb5dl 244 27 of of IN cord-324859-0yuhb5dl 244 28 immune immune JJ cord-324859-0yuhb5dl 244 29 - - HYPH cord-324859-0yuhb5dl 244 30 active active JJ cord-324859-0yuhb5dl 244 31 molecules molecule NNS cord-324859-0yuhb5dl 244 32 involved involve VBN cord-324859-0yuhb5dl 244 33 in in IN cord-324859-0yuhb5dl 244 34 the the DT cord-324859-0yuhb5dl 244 35 SARS SARS NNP cord-324859-0yuhb5dl 244 36 - - HYPH cord-324859-0yuhb5dl 244 37 CoV-2-driven CoV-2-driven VBN cord-324859-0yuhb5dl 244 38 cytokine cytokine NN cord-324859-0yuhb5dl 244 39 storm storm NN cord-324859-0yuhb5dl 244 40 . . . cord-324859-0yuhb5dl 245 1 Moreover moreover RB cord-324859-0yuhb5dl 245 2 , , , cord-324859-0yuhb5dl 245 3 all all PDT cord-324859-0yuhb5dl 245 4 the the DT cord-324859-0yuhb5dl 245 5 studies study NNS cord-324859-0yuhb5dl 245 6 included include VBN cord-324859-0yuhb5dl 245 7 in in IN cord-324859-0yuhb5dl 245 8 the the DT cord-324859-0yuhb5dl 245 9 meta meta NNP cord-324859-0yuhb5dl 245 10 - - HYPH cord-324859-0yuhb5dl 245 11 analysis analysis NN cord-324859-0yuhb5dl 245 12 are be VBP cord-324859-0yuhb5dl 245 13 from from IN cord-324859-0yuhb5dl 245 14 China China NNP cord-324859-0yuhb5dl 245 15 . . . cord-324859-0yuhb5dl 246 1 Our -PRON- PRP$ cord-324859-0yuhb5dl 246 2 literature literature NN cord-324859-0yuhb5dl 246 3 search search NN cord-324859-0yuhb5dl 246 4 was be VBD cord-324859-0yuhb5dl 246 5 conducted conduct VBN cord-324859-0yuhb5dl 246 6 during during IN cord-324859-0yuhb5dl 246 7 the the DT cord-324859-0yuhb5dl 246 8 initial initial JJ cord-324859-0yuhb5dl 246 9 months month NNS cord-324859-0yuhb5dl 246 10 of of IN cord-324859-0yuhb5dl 246 11 the the DT cord-324859-0yuhb5dl 246 12 pandemic pandemic NN cord-324859-0yuhb5dl 246 13 , , , cord-324859-0yuhb5dl 246 14 wherein wherein WRB cord-324859-0yuhb5dl 246 15 most most JJS cord-324859-0yuhb5dl 246 16 of of IN cord-324859-0yuhb5dl 246 17 the the DT cord-324859-0yuhb5dl 246 18 available available JJ cord-324859-0yuhb5dl 246 19 data datum NNS cord-324859-0yuhb5dl 246 20 was be VBD cord-324859-0yuhb5dl 246 21 from from IN cord-324859-0yuhb5dl 246 22 Chinese chinese JJ cord-324859-0yuhb5dl 246 23 patients patient NNS cord-324859-0yuhb5dl 246 24 . . . cord-324859-0yuhb5dl 247 1 This this DT cord-324859-0yuhb5dl 247 2 could could MD cord-324859-0yuhb5dl 247 3 limit limit VB cord-324859-0yuhb5dl 247 4 the the DT cord-324859-0yuhb5dl 247 5 generalizability generalizability NN cord-324859-0yuhb5dl 247 6 of of IN cord-324859-0yuhb5dl 247 7 our -PRON- PRP$ cord-324859-0yuhb5dl 247 8 findings finding NNS cord-324859-0yuhb5dl 247 9 to to IN cord-324859-0yuhb5dl 247 10 some some DT cord-324859-0yuhb5dl 247 11 extent extent NN cord-324859-0yuhb5dl 247 12 . . . cord-324859-0yuhb5dl 248 1 Since since IN cord-324859-0yuhb5dl 248 2 levels level NNS cord-324859-0yuhb5dl 248 3 of of IN cord-324859-0yuhb5dl 248 4 inflammatory inflammatory JJ cord-324859-0yuhb5dl 248 5 markers marker NNS cord-324859-0yuhb5dl 248 6 can can MD cord-324859-0yuhb5dl 248 7 vary vary VB cord-324859-0yuhb5dl 248 8 over over IN cord-324859-0yuhb5dl 248 9 the the DT cord-324859-0yuhb5dl 248 10 course course NN cord-324859-0yuhb5dl 248 11 of of IN cord-324859-0yuhb5dl 248 12 the the DT cord-324859-0yuhb5dl 248 13 infection infection NN cord-324859-0yuhb5dl 248 14 , , , cord-324859-0yuhb5dl 248 15 the the DT cord-324859-0yuhb5dl 248 16 timing timing NN cord-324859-0yuhb5dl 248 17 of of IN cord-324859-0yuhb5dl 248 18 laboratory laboratory NN cord-324859-0yuhb5dl 248 19 assessments assessment NNS cord-324859-0yuhb5dl 248 20 can can MD cord-324859-0yuhb5dl 248 21 also also RB cord-324859-0yuhb5dl 248 22 impact impact VB cord-324859-0yuhb5dl 248 23 the the DT cord-324859-0yuhb5dl 248 24 findings finding NNS cord-324859-0yuhb5dl 248 25 . . . cord-324859-0yuhb5dl 249 1 However however RB cord-324859-0yuhb5dl 249 2 , , , cord-324859-0yuhb5dl 249 3 the the DT cord-324859-0yuhb5dl 249 4 median median JJ cord-324859-0yuhb5dl 249 5 time time NN cord-324859-0yuhb5dl 249 6 from from IN cord-324859-0yuhb5dl 249 7 symptom symptom NN cord-324859-0yuhb5dl 249 8 onset onset NN cord-324859-0yuhb5dl 249 9 to to IN cord-324859-0yuhb5dl 249 10 hospitalization hospitalization NN cord-324859-0yuhb5dl 249 11 was be VBD cord-324859-0yuhb5dl 249 12 reported report VBN cord-324859-0yuhb5dl 249 13 by by IN cord-324859-0yuhb5dl 249 14 nearly nearly RB cord-324859-0yuhb5dl 249 15 one one CD cord-324859-0yuhb5dl 249 16 - - HYPH cord-324859-0yuhb5dl 249 17 third third NN cord-324859-0yuhb5dl 249 18 of of IN cord-324859-0yuhb5dl 249 19 the the DT cord-324859-0yuhb5dl 249 20 studies study NNS cord-324859-0yuhb5dl 249 21 and and CC cord-324859-0yuhb5dl 249 22 it -PRON- PRP cord-324859-0yuhb5dl 249 23 ranged range VBD cord-324859-0yuhb5dl 249 24 from from IN cord-324859-0yuhb5dl 249 25 7 7 CD cord-324859-0yuhb5dl 249 26 - - SYM cord-324859-0yuhb5dl 249 27 11 11 CD cord-324859-0yuhb5dl 249 28 days day NNS cord-324859-0yuhb5dl 249 29 . . . cord-324859-0yuhb5dl 250 1 Lastly lastly RB cord-324859-0yuhb5dl 250 2 , , , cord-324859-0yuhb5dl 250 3 we -PRON- PRP cord-324859-0yuhb5dl 250 4 could could MD cord-324859-0yuhb5dl 250 5 not not RB cord-324859-0yuhb5dl 250 6 include include VB cord-324859-0yuhb5dl 250 7 non non JJ cord-324859-0yuhb5dl 250 8 - - JJ cord-324859-0yuhb5dl 250 9 English english JJ cord-324859-0yuhb5dl 250 10 articles article NNS cord-324859-0yuhb5dl 250 11 due due JJ cord-324859-0yuhb5dl 250 12 to to IN cord-324859-0yuhb5dl 250 13 unavailability unavailability NN cord-324859-0yuhb5dl 250 14 of of IN cord-324859-0yuhb5dl 250 15 appropriate appropriate JJ cord-324859-0yuhb5dl 250 16 translators translator NNS cord-324859-0yuhb5dl 250 17 . . . cord-324859-0yuhb5dl 251 1 Our -PRON- PRP$ cord-324859-0yuhb5dl 251 2 findings finding NNS cord-324859-0yuhb5dl 251 3 showed show VBD cord-324859-0yuhb5dl 251 4 that that IN cord-324859-0yuhb5dl 251 5 severe severe JJ cord-324859-0yuhb5dl 251 6 COVID-19 covid-19 NN cord-324859-0yuhb5dl 251 7 was be VBD cord-324859-0yuhb5dl 251 8 characterized characterize VBN cord-324859-0yuhb5dl 251 9 by by IN cord-324859-0yuhb5dl 251 10 elevated elevated JJ cord-324859-0yuhb5dl 251 11 circulating circulating JJ cord-324859-0yuhb5dl 251 12 levels level NNS cord-324859-0yuhb5dl 251 13 of of IN cord-324859-0yuhb5dl 251 14 pro pro JJ cord-324859-0yuhb5dl 251 15 - - JJ cord-324859-0yuhb5dl 251 16 inflammatory inflammatory JJ cord-324859-0yuhb5dl 251 17 cytokines cytokine NNS cord-324859-0yuhb5dl 251 18 and and CC cord-324859-0yuhb5dl 251 19 lower low JJR cord-324859-0yuhb5dl 251 20 levels level NNS cord-324859-0yuhb5dl 251 21 of of IN cord-324859-0yuhb5dl 251 22 T t NN cord-324859-0yuhb5dl 251 23 lymphocytes lymphocyte NNS cord-324859-0yuhb5dl 251 24 , , , cord-324859-0yuhb5dl 251 25 when when WRB cord-324859-0yuhb5dl 251 26 compared compare VBN cord-324859-0yuhb5dl 251 27 to to IN cord-324859-0yuhb5dl 251 28 patients patient NNS cord-324859-0yuhb5dl 251 29 with with IN cord-324859-0yuhb5dl 251 30 mild mild JJ cord-324859-0yuhb5dl 251 31 - - HYPH cord-324859-0yuhb5dl 251 32 to to IN cord-324859-0yuhb5dl 251 33 - - HYPH cord-324859-0yuhb5dl 251 34 moderate moderate JJ cord-324859-0yuhb5dl 251 35 disease disease NN cord-324859-0yuhb5dl 251 36 . . . cord-324859-0yuhb5dl 252 1 However however RB cord-324859-0yuhb5dl 252 2 , , , cord-324859-0yuhb5dl 252 3 welldesigned welldesigne VBN cord-324859-0yuhb5dl 252 4 and and CC cord-324859-0yuhb5dl 252 5 adequately adequately RB cord-324859-0yuhb5dl 252 6 powered power VBD cord-324859-0yuhb5dl 252 7 prospective prospective JJ cord-324859-0yuhb5dl 252 8 studies study NNS cord-324859-0yuhb5dl 252 9 are be VBP cord-324859-0yuhb5dl 252 10 warranted warrant VBN cord-324859-0yuhb5dl 252 11 to to TO cord-324859-0yuhb5dl 252 12 further further RB cord-324859-0yuhb5dl 252 13 strengthen strengthen VB cord-324859-0yuhb5dl 252 14 the the DT cord-324859-0yuhb5dl 252 15 current current JJ cord-324859-0yuhb5dl 252 16 evidence evidence NN cord-324859-0yuhb5dl 252 17 base base NN cord-324859-0yuhb5dl 252 18 . . . cord-324859-0yuhb5dl 253 1 Prospective prospective JJ cord-324859-0yuhb5dl 253 2 studies study NNS cord-324859-0yuhb5dl 253 3 that that WDT cord-324859-0yuhb5dl 253 4 follow follow VBP cord-324859-0yuhb5dl 253 5 a a DT cord-324859-0yuhb5dl 253 6 structured structured JJ cord-324859-0yuhb5dl 253 7 approach approach NN cord-324859-0yuhb5dl 253 8 towards towards IN cord-324859-0yuhb5dl 253 9 intensive intensive JJ cord-324859-0yuhb5dl 253 10 immune immune JJ cord-324859-0yuhb5dl 253 11 monitoring monitoring NN cord-324859-0yuhb5dl 253 12 along along IN cord-324859-0yuhb5dl 253 13 with with IN cord-324859-0yuhb5dl 253 14 daily daily JJ cord-324859-0yuhb5dl 253 15 clinical clinical JJ cord-324859-0yuhb5dl 253 16 evaluations evaluation NNS cord-324859-0yuhb5dl 253 17 can can MD cord-324859-0yuhb5dl 253 18 further further RB cord-324859-0yuhb5dl 253 19 elucidate elucidate VB cord-324859-0yuhb5dl 253 20 the the DT cord-324859-0yuhb5dl 253 21 mechanisms mechanism NNS cord-324859-0yuhb5dl 253 22 underlying underlie VBG cord-324859-0yuhb5dl 253 23 COVID-19 covid-19 CD cord-324859-0yuhb5dl 253 24 immunopathology immunopathology NN cord-324859-0yuhb5dl 253 25 . . . cord-324859-0yuhb5dl 254 1 Such such JJ cord-324859-0yuhb5dl 254 2 data datum NNS cord-324859-0yuhb5dl 254 3 will will MD cord-324859-0yuhb5dl 254 4 be be VB cord-324859-0yuhb5dl 254 5 crucial crucial JJ cord-324859-0yuhb5dl 254 6 in in IN cord-324859-0yuhb5dl 254 7 resolving resolve VBG cord-324859-0yuhb5dl 254 8 the the DT cord-324859-0yuhb5dl 254 9 clinical clinical JJ cord-324859-0yuhb5dl 254 10 dilemmas dilemma NNS cord-324859-0yuhb5dl 254 11 related relate VBN cord-324859-0yuhb5dl 254 12 to to IN cord-324859-0yuhb5dl 254 13 the the DT cord-324859-0yuhb5dl 254 14 timing timing NN cord-324859-0yuhb5dl 254 15 and and CC cord-324859-0yuhb5dl 254 16 type type NN cord-324859-0yuhb5dl 254 17 of of IN cord-324859-0yuhb5dl 254 18 anti anti JJ cord-324859-0yuhb5dl 254 19 - - JJ cord-324859-0yuhb5dl 254 20 COVID-19 covid-19 JJ cord-324859-0yuhb5dl 254 21 therapy therapy NN cord-324859-0yuhb5dl 254 22 . . . cord-324859-0yuhb5dl 255 1 Given give VBN cord-324859-0yuhb5dl 255 2 the the DT cord-324859-0yuhb5dl 255 3 urgency urgency NN cord-324859-0yuhb5dl 255 4 of of IN cord-324859-0yuhb5dl 255 5 generating generate VBG cord-324859-0yuhb5dl 255 6 scientific scientific JJ cord-324859-0yuhb5dl 255 7 data datum NNS cord-324859-0yuhb5dl 255 8 to to TO cord-324859-0yuhb5dl 255 9 help help VB cord-324859-0yuhb5dl 255 10 understand understand VB cord-324859-0yuhb5dl 255 11 the the DT cord-324859-0yuhb5dl 255 12 disease disease NN cord-324859-0yuhb5dl 255 13 and and CC cord-324859-0yuhb5dl 255 14 its -PRON- PRP$ cord-324859-0yuhb5dl 255 15 shortterm shortterm JJ cord-324859-0yuhb5dl 255 16 and and CC cord-324859-0yuhb5dl 255 17 long long JJ cord-324859-0yuhb5dl 255 18 - - HYPH cord-324859-0yuhb5dl 255 19 term term NN cord-324859-0yuhb5dl 255 20 implications implication NNS cord-324859-0yuhb5dl 255 21 , , , cord-324859-0yuhb5dl 255 22 it -PRON- PRP cord-324859-0yuhb5dl 255 23 is be VBZ cord-324859-0yuhb5dl 255 24 understandable understandable JJ cord-324859-0yuhb5dl 255 25 that that IN cord-324859-0yuhb5dl 255 26 efforts effort NNS cord-324859-0yuhb5dl 255 27 are be VBP cord-324859-0yuhb5dl 255 28 underway underway JJ cord-324859-0yuhb5dl 255 29 to to TO cord-324859-0yuhb5dl 255 30 make make VB cord-324859-0yuhb5dl 255 31 research research NN cord-324859-0yuhb5dl 255 32 publicly publicly RB cord-324859-0yuhb5dl 255 33 available available JJ cord-324859-0yuhb5dl 255 34 as as RB cord-324859-0yuhb5dl 255 35 soon soon RB cord-324859-0yuhb5dl 255 36 as as IN cord-324859-0yuhb5dl 255 37 possible possible JJ cord-324859-0yuhb5dl 255 38 . . . cord-324859-0yuhb5dl 256 1 But but CC cord-324859-0yuhb5dl 256 2 studies study NNS cord-324859-0yuhb5dl 256 3 that that WDT cord-324859-0yuhb5dl 256 4 are be VBP cord-324859-0yuhb5dl 256 5 methodologically methodologically RB cord-324859-0yuhb5dl 256 6 sound sound JJ cord-324859-0yuhb5dl 256 7 and and CC cord-324859-0yuhb5dl 256 8 involve involve VBP cord-324859-0yuhb5dl 256 9 thorough thorough JJ cord-324859-0yuhb5dl 256 10 reporting reporting NN cord-324859-0yuhb5dl 256 11 of of IN cord-324859-0yuhb5dl 256 12 essential essential JJ cord-324859-0yuhb5dl 256 13 aspects aspect NNS cord-324859-0yuhb5dl 256 14 are be VBP cord-324859-0yuhb5dl 256 15 lacking lack VBG cord-324859-0yuhb5dl 256 16 . . . cord-324859-0yuhb5dl 257 1 We -PRON- PRP cord-324859-0yuhb5dl 257 2 believe believe VBP cord-324859-0yuhb5dl 257 3 the the DT cord-324859-0yuhb5dl 257 4 several several JJ cord-324859-0yuhb5dl 257 5 ongoing ongoing JJ cord-324859-0yuhb5dl 257 6 studies study NNS cord-324859-0yuhb5dl 257 7 evaluating evaluate VBG cord-324859-0yuhb5dl 257 8 the the DT cord-324859-0yuhb5dl 257 9 role role NN cord-324859-0yuhb5dl 257 10 of of IN cord-324859-0yuhb5dl 257 11 immunomodulation immunomodulation NN cord-324859-0yuhb5dl 257 12 in in IN cord-324859-0yuhb5dl 257 13 severe severe JJ cord-324859-0yuhb5dl 257 14 COVID-19 covid-19 JJ cord-324859-0yuhb5dl 257 15 patients patient NNS cord-324859-0yuhb5dl 257 16 can can MD cord-324859-0yuhb5dl 257 17 hopefully hopefully RB cord-324859-0yuhb5dl 257 18 provide provide VB cord-324859-0yuhb5dl 257 19 further further JJ cord-324859-0yuhb5dl 257 20 clarity clarity NN cord-324859-0yuhb5dl 257 21 , , , cord-324859-0yuhb5dl 257 22 and and CC cord-324859-0yuhb5dl 257 23 these these DT cord-324859-0yuhb5dl 257 24 therapies therapy NNS cord-324859-0yuhb5dl 257 25 may may MD cord-324859-0yuhb5dl 257 26 prove prove VB cord-324859-0yuhb5dl 257 27 instrumental instrumental JJ cord-324859-0yuhb5dl 257 28 in in IN cord-324859-0yuhb5dl 257 29 tackling tackle VBG cord-324859-0yuhb5dl 257 30 hyperinflammation hyperinflammation NN cord-324859-0yuhb5dl 257 31 to to TO cord-324859-0yuhb5dl 257 32 improve improve VB cord-324859-0yuhb5dl 257 33 patient patient JJ cord-324859-0yuhb5dl 257 34 management management NN cord-324859-0yuhb5dl 257 35 and and CC cord-324859-0yuhb5dl 257 36 clinical clinical JJ cord-324859-0yuhb5dl 257 37 outcomes outcome NNS cord-324859-0yuhb5dl 257 38 . . . cord-324859-0yuhb5dl 258 1 Coronavirus Coronavirus NNP cord-324859-0yuhb5dl 258 2 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 259 1 ( ( -LRB- cord-324859-0yuhb5dl 259 2 2019-nCoV 2019-ncov LS cord-324859-0yuhb5dl 259 3 ) ) -RRB- cord-324859-0yuhb5dl 259 4 Dashboard dashboard NN cord-324859-0yuhb5dl 259 5 by by IN cord-324859-0yuhb5dl 259 6 the the DT cord-324859-0yuhb5dl 259 7 CCSE CCSE NNP cord-324859-0yuhb5dl 259 8 at at IN cord-324859-0yuhb5dl 259 9 Johns Johns NNP cord-324859-0yuhb5dl 259 10 Hopkins Hopkins NNP cord-324859-0yuhb5dl 259 11 University University NNP cord-324859-0yuhb5dl 259 12 Coronavirus Coronavirus NNP cord-324859-0yuhb5dl 259 13 infections infection NNS cord-324859-0yuhb5dl 259 14 and and CC cord-324859-0yuhb5dl 259 15 immune immune JJ cord-324859-0yuhb5dl 259 16 responses response NNS cord-324859-0yuhb5dl 259 17 Coronavirus Coronavirus NNP cord-324859-0yuhb5dl 259 18 is be VBZ cord-324859-0yuhb5dl 259 19 the the DT cord-324859-0yuhb5dl 259 20 trigger trigger NN cord-324859-0yuhb5dl 259 21 , , , cord-324859-0yuhb5dl 259 22 but but CC cord-324859-0yuhb5dl 259 23 the the DT cord-324859-0yuhb5dl 259 24 immune immune JJ cord-324859-0yuhb5dl 259 25 response response NN cord-324859-0yuhb5dl 259 26 is be VBZ cord-324859-0yuhb5dl 259 27 deadly deadly JJ cord-324859-0yuhb5dl 259 28 The the DT cord-324859-0yuhb5dl 259 29 cytokine cytokine NN cord-324859-0yuhb5dl 259 30 storm storm NN cord-324859-0yuhb5dl 259 31 in in IN cord-324859-0yuhb5dl 259 32 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 259 33 : : : cord-324859-0yuhb5dl 259 34 an an DT cord-324859-0yuhb5dl 259 35 overview overview NN cord-324859-0yuhb5dl 259 36 of of IN cord-324859-0yuhb5dl 259 37 the the DT cord-324859-0yuhb5dl 259 38 involvement involvement NN cord-324859-0yuhb5dl 259 39 of of IN cord-324859-0yuhb5dl 259 40 the the DT cord-324859-0yuhb5dl 259 41 chemokine chemokine NN cord-324859-0yuhb5dl 259 42 / / SYM cord-324859-0yuhb5dl 259 43 chemokine chemokine NN cord-324859-0yuhb5dl 259 44 - - HYPH cord-324859-0yuhb5dl 259 45 receptor receptor NN cord-324859-0yuhb5dl 259 46 system system NN cord-324859-0yuhb5dl 259 47 On on IN cord-324859-0yuhb5dl 259 48 the the DT cord-324859-0yuhb5dl 259 49 Alert Alert NNP cord-324859-0yuhb5dl 259 50 for for IN cord-324859-0yuhb5dl 259 51 Cytokine Cytokine NNP cord-324859-0yuhb5dl 259 52 Storm Storm NNP cord-324859-0yuhb5dl 259 53 : : : cord-324859-0yuhb5dl 259 54 Immunopathology immunopathology NN cord-324859-0yuhb5dl 259 55 in in IN cord-324859-0yuhb5dl 259 56 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 259 57 . . . cord-324859-0yuhb5dl 260 1 Arthritis Arthritis NNP cord-324859-0yuhb5dl 260 2 Rheumatol Rheumatol NNP cord-324859-0yuhb5dl 261 1 The the DT cord-324859-0yuhb5dl 261 2 rheumatologist rheumatologist NN cord-324859-0yuhb5dl 261 3 's 's POS cord-324859-0yuhb5dl 261 4 role role NN cord-324859-0yuhb5dl 261 5 in in IN cord-324859-0yuhb5dl 261 6 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 261 7 Clinical clinical JJ cord-324859-0yuhb5dl 261 8 and and CC cord-324859-0yuhb5dl 261 9 immunological immunological JJ cord-324859-0yuhb5dl 261 10 features feature NNS cord-324859-0yuhb5dl 261 11 of of IN cord-324859-0yuhb5dl 261 12 severe severe JJ cord-324859-0yuhb5dl 261 13 and and CC cord-324859-0yuhb5dl 261 14 moderate moderate JJ cord-324859-0yuhb5dl 261 15 coronavirus coronavirus NN cord-324859-0yuhb5dl 261 16 disease disease NN cord-324859-0yuhb5dl 261 17 2019 2019 CD cord-324859-0yuhb5dl 262 1 The the DT cord-324859-0yuhb5dl 262 2 potential potential JJ cord-324859-0yuhb5dl 262 3 role role NN cord-324859-0yuhb5dl 262 4 of of IN cord-324859-0yuhb5dl 262 5 IL-6 IL-6 NNP cord-324859-0yuhb5dl 262 6 in in IN cord-324859-0yuhb5dl 262 7 monitoring monitor VBG cord-324859-0yuhb5dl 262 8 severe severe JJ cord-324859-0yuhb5dl 262 9 case case NN cord-324859-0yuhb5dl 262 10 of of IN cord-324859-0yuhb5dl 262 11 coronavirus coronavirus NN cord-324859-0yuhb5dl 262 12 disease disease NN cord-324859-0yuhb5dl 262 13 2019 2019 CD cord-324859-0yuhb5dl 262 14 A a DT cord-324859-0yuhb5dl 262 15 glimpse glimpse NN cord-324859-0yuhb5dl 262 16 into into IN cord-324859-0yuhb5dl 262 17 the the DT cord-324859-0yuhb5dl 262 18 eye eye NN cord-324859-0yuhb5dl 262 19 of of IN cord-324859-0yuhb5dl 262 20 the the DT cord-324859-0yuhb5dl 262 21 COVID-19 covid-19 JJ cord-324859-0yuhb5dl 262 22 cytokine cytokine NN cord-324859-0yuhb5dl 262 23 storm storm NN cord-324859-0yuhb5dl 262 24 Interleukin-6 Interleukin-6 NNP cord-324859-0yuhb5dl 262 25 in in IN cord-324859-0yuhb5dl 262 26 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 262 27 : : : cord-324859-0yuhb5dl 262 28 a a DT cord-324859-0yuhb5dl 262 29 systematic systematic JJ cord-324859-0yuhb5dl 262 30 review review NN cord-324859-0yuhb5dl 262 31 and and CC cord-324859-0yuhb5dl 262 32 meta meta NNP cord-324859-0yuhb5dl 262 33 - - HYPH cord-324859-0yuhb5dl 262 34 analysis analysis NN cord-324859-0yuhb5dl 262 35 . . . cord-324859-0yuhb5dl 263 1 medRxiv medRxiv NNP cord-324859-0yuhb5dl 263 2 Elevated Elevated NNP cord-324859-0yuhb5dl 263 3 interleukin-6 interleukin-6 NNP cord-324859-0yuhb5dl 263 4 and and CC cord-324859-0yuhb5dl 263 5 severe severe JJ cord-324859-0yuhb5dl 263 6 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 263 7 : : : cord-324859-0yuhb5dl 263 8 a a DT cord-324859-0yuhb5dl 263 9 meta meta JJ cord-324859-0yuhb5dl 263 10 - - HYPH cord-324859-0yuhb5dl 263 11 analysis analysis NN cord-324859-0yuhb5dl 263 12 Interleukin-6 Interleukin-6 NNP cord-324859-0yuhb5dl 263 13 as as IN cord-324859-0yuhb5dl 263 14 a a DT cord-324859-0yuhb5dl 263 15 potential potential JJ cord-324859-0yuhb5dl 263 16 biomarker biomarker NN cord-324859-0yuhb5dl 263 17 of of IN cord-324859-0yuhb5dl 263 18 COVID-19 covid-19 JJ cord-324859-0yuhb5dl 263 19 progression progression NN cord-324859-0yuhb5dl 263 20 Hematologic Hematologic NNP cord-324859-0yuhb5dl 263 21 , , , cord-324859-0yuhb5dl 263 22 biochemical biochemical JJ cord-324859-0yuhb5dl 263 23 and and CC cord-324859-0yuhb5dl 263 24 immune immune JJ cord-324859-0yuhb5dl 263 25 biomarker biomarker NN cord-324859-0yuhb5dl 263 26 abnormalities abnormality NNS cord-324859-0yuhb5dl 263 27 associated associate VBN cord-324859-0yuhb5dl 263 28 with with IN cord-324859-0yuhb5dl 263 29 severe severe JJ cord-324859-0yuhb5dl 263 30 illness illness NN cord-324859-0yuhb5dl 263 31 and and CC cord-324859-0yuhb5dl 263 32 mortality mortality NN cord-324859-0yuhb5dl 263 33 in in IN cord-324859-0yuhb5dl 263 34 coronavirus coronavirus NN cord-324859-0yuhb5dl 263 35 disease disease NN cord-324859-0yuhb5dl 263 36 2019 2019 CD cord-324859-0yuhb5dl 263 37 ( ( -LRB- cord-324859-0yuhb5dl 263 38 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 263 39 ) ) -RRB- cord-324859-0yuhb5dl 263 40 : : : cord-324859-0yuhb5dl 263 41 a a DT cord-324859-0yuhb5dl 263 42 meta meta JJ cord-324859-0yuhb5dl 263 43 - - HYPH cord-324859-0yuhb5dl 263 44 analysis analysis NN cord-324859-0yuhb5dl 263 45 Novel Novel NNP cord-324859-0yuhb5dl 263 46 coronavirus coronavirus NN cord-324859-0yuhb5dl 263 47 infection infection NN cord-324859-0yuhb5dl 263 48 ( ( -LRB- cord-324859-0yuhb5dl 263 49 COVID-19 covid-19 VB cord-324859-0yuhb5dl 263 50 ) ) -RRB- cord-324859-0yuhb5dl 263 51 in in IN cord-324859-0yuhb5dl 263 52 humans human NNS cord-324859-0yuhb5dl 263 53 : : : cord-324859-0yuhb5dl 263 54 a a DT cord-324859-0yuhb5dl 263 55 scoping scoping NN cord-324859-0yuhb5dl 263 56 review review NN cord-324859-0yuhb5dl 263 57 and and CC cord-324859-0yuhb5dl 263 58 meta meta NNP cord-324859-0yuhb5dl 263 59 - - HYPH cord-324859-0yuhb5dl 263 60 analysis analysis NN cord-324859-0yuhb5dl 263 61 Recor Recor NNP cord-324859-0yuhb5dl 263 62 dID=183246 did=183246 JJ cord-324859-0yuhb5dl 263 63 . . . cord-324859-0yuhb5dl 264 1 Accessed access VBN cord-324859-0yuhb5dl 264 2 The the DT cord-324859-0yuhb5dl 264 3 PRISMA PRISMA NNP cord-324859-0yuhb5dl 264 4 Group Group NNP cord-324859-0yuhb5dl 264 5 . . . cord-324859-0yuhb5dl 265 1 Preferred preferred JJ cord-324859-0yuhb5dl 265 2 reporting reporting NN cord-324859-0yuhb5dl 265 3 items item NNS cord-324859-0yuhb5dl 265 4 for for IN cord-324859-0yuhb5dl 265 5 systematic systematic JJ cord-324859-0yuhb5dl 265 6 reviews review NNS cord-324859-0yuhb5dl 265 7 and and CC cord-324859-0yuhb5dl 265 8 meta meta NNP cord-324859-0yuhb5dl 265 9 - - HYPH cord-324859-0yuhb5dl 265 10 analyses analysis NNS cord-324859-0yuhb5dl 265 11 : : : cord-324859-0yuhb5dl 265 12 the the DT cord-324859-0yuhb5dl 265 13 PRISMA PRISMA NNP cord-324859-0yuhb5dl 265 14 Statement Statement NNP cord-324859-0yuhb5dl 265 15 repor repor NNP cord-324859-0yuhb5dl 265 16 ting ting NNP cord-324859-0yuhb5dl 265 17 - - HYPH cord-324859-0yuhb5dl 265 18 guide guide VB cord-324859-0yuhb5dl 265 19 lines/ lines/ ADD cord-324859-0yuhb5dl 265 20 meta meta NNP cord-324859-0yuhb5dl 265 21 - - HYPH cord-324859-0yuhb5dl 265 22 analy analy NNP cord-324859-0yuhb5dl 265 23 sis sis NNP cord-324859-0yuhb5dl 265 24 - - HYPH cord-324859-0yuhb5dl 265 25 of of IN cord-324859-0yuhb5dl 265 26 - - HYPH cord-324859-0yuhb5dl 265 27 obser obser FW cord-324859-0yuhb5dl 265 28 vatio vatio FW cord-324859-0yuhb5dl 265 29 nal nal NNP cord-324859-0yuhb5dl 265 30 - - HYPH cord-324859-0yuhb5dl 265 31 studi studi NNP cord-324859-0yuhb5dl 265 32 es es NNP cord-324859-0yuhb5dl 265 33 - - HYPH cord-324859-0yuhb5dl 265 34 in in IN cord-324859-0yuhb5dl 265 35 - - HYPH cord-324859-0yuhb5dl 265 36 epide epide NN cord-324859-0yuhb5dl 265 37 miolo miolo NNP cord-324859-0yuhb5dl 265 38 gy gy NNP cord-324859-0yuhb5dl 265 39 - - HYPH cord-324859-0yuhb5dl 265 40 a a DT cord-324859-0yuhb5dl 265 41 - - HYPH cord-324859-0yuhb5dl 265 42 propo propo NN cord-324859-0yuhb5dl 265 43 sal sal NN cord-324859-0yuhb5dl 265 44 - - HYPH cord-324859-0yuhb5dl 265 45 for for IN cord-324859-0yuhb5dl 265 46 - - HYPH cord-324859-0yuhb5dl 265 47 repor repor NN cord-324859-0yuhb5dl 265 48 ting ting NNP cord-324859-0yuhb5dl 265 49 - - HYPH cord-324859-0yuhb5dl 265 50 meta meta NNP cord-324859-0yuhb5dl 265 51 - - HYPH cord-324859-0yuhb5dl 265 52 analy analy NNP cord-324859-0yuhb5dl 266 1 sis sis NN cord-324859-0yuhb5dl 266 2 - - HYPH cord-324859-0yuhb5dl 266 3 of of IN cord-324859-0yuhb5dl 266 4 - - HYPH cord-324859-0yuhb5dl 266 5 obser obser FW cord-324859-0yuhb5dl 266 6 vatio vatio FW cord-324859-0yuhb5dl 266 7 nal nal NNP cord-324859-0yuhb5dl 266 8 - - HYPH cord-324859-0yuhb5dl 266 9 studi studi NNP cord-324859-0yuhb5dl 267 1 es es JJ cord-324859-0yuhb5dl 267 2 - - HYPH cord-324859-0yuhb5dl 267 3 in in IN cord-324859-0yuhb5dl 267 4 - - HYPH cord-324859-0yuhb5dl 267 5 epide epide NN cord-324859-0yuhb5dl 267 6 miolo miolo NNP cord-324859-0yuhb5dl 267 7 gy gy NNP cord-324859-0yuhb5dl 267 8 - - HYPH cord-324859-0yuhb5dl 267 9 moose moose NNP cord-324859-0yuhb5dl 267 10 -group/ -group/ NNP cord-324859-0yuhb5dl 268 1 Accessed access VBN cord-324859-0yuhb5dl 268 2 Estimating estimate VBG cord-324859-0yuhb5dl 268 3 the the DT cord-324859-0yuhb5dl 268 4 sample sample NN cord-324859-0yuhb5dl 268 5 mean mean NN cord-324859-0yuhb5dl 268 6 and and CC cord-324859-0yuhb5dl 268 7 standard standard JJ cord-324859-0yuhb5dl 268 8 deviation deviation NN cord-324859-0yuhb5dl 268 9 from from IN cord-324859-0yuhb5dl 268 10 the the DT cord-324859-0yuhb5dl 268 11 sample sample NN cord-324859-0yuhb5dl 268 12 size size NN cord-324859-0yuhb5dl 268 13 , , , cord-324859-0yuhb5dl 268 14 median median NN cord-324859-0yuhb5dl 268 15 , , , cord-324859-0yuhb5dl 268 16 range range NN cord-324859-0yuhb5dl 269 1 and/or and/or CC cord-324859-0yuhb5dl 270 1 interquartile interquartile JJ cord-324859-0yuhb5dl 270 2 range range VBP cord-324859-0yuhb5dl 270 3 Meta Meta NNP cord-324859-0yuhb5dl 270 4 - - HYPH cord-324859-0yuhb5dl 270 5 analysis analysis NN cord-324859-0yuhb5dl 270 6 in in IN cord-324859-0yuhb5dl 270 7 clinical clinical JJ cord-324859-0yuhb5dl 270 8 trials trial NNS cord-324859-0yuhb5dl 271 1 Identifying identify VBG cord-324859-0yuhb5dl 271 2 and and CC cord-324859-0yuhb5dl 271 3 measuring measure VBG cord-324859-0yuhb5dl 271 4 heterogeneity heterogeneity NN cord-324859-0yuhb5dl 272 1 The the DT cord-324859-0yuhb5dl 272 2 Newcastle Newcastle NNP cord-324859-0yuhb5dl 272 3 - - HYPH cord-324859-0yuhb5dl 272 4 Ottawa Ottawa NNP cord-324859-0yuhb5dl 272 5 Scale Scale NNP cord-324859-0yuhb5dl 272 6 for for IN cord-324859-0yuhb5dl 272 7 assessing assess VBG cord-324859-0yuhb5dl 272 8 the the DT cord-324859-0yuhb5dl 272 9 quality quality NN cord-324859-0yuhb5dl 272 10 of of IN cord-324859-0yuhb5dl 272 11 non non JJ cord-324859-0yuhb5dl 272 12 - - JJ cord-324859-0yuhb5dl 272 13 randomized randomized JJ cord-324859-0yuhb5dl 272 14 studies study NNS cord-324859-0yuhb5dl 272 15 in in IN cord-324859-0yuhb5dl 272 16 meta meta NNP cord-324859-0yuhb5dl 272 17 - - HYPH cord-324859-0yuhb5dl 272 18 analyses analysis NNS cord-324859-0yuhb5dl 272 19 Bias Bias NNP cord-324859-0yuhb5dl 272 20 in in IN cord-324859-0yuhb5dl 272 21 meta meta NNP cord-324859-0yuhb5dl 272 22 - - HYPH cord-324859-0yuhb5dl 272 23 analysis analysis NN cord-324859-0yuhb5dl 272 24 detected detect VBN cord-324859-0yuhb5dl 272 25 by by IN cord-324859-0yuhb5dl 272 26 a a DT cord-324859-0yuhb5dl 272 27 simple simple JJ cord-324859-0yuhb5dl 272 28 , , , cord-324859-0yuhb5dl 272 29 graphical graphical JJ cord-324859-0yuhb5dl 272 30 test test NN cord-324859-0yuhb5dl 272 31 Epidemiological epidemiological JJ cord-324859-0yuhb5dl 272 32 characteristics characteristic NNS cord-324859-0yuhb5dl 272 33 and and CC cord-324859-0yuhb5dl 272 34 clinical clinical JJ cord-324859-0yuhb5dl 272 35 features feature NNS cord-324859-0yuhb5dl 272 36 of of IN cord-324859-0yuhb5dl 272 37 32 32 CD cord-324859-0yuhb5dl 272 38 critical critical JJ cord-324859-0yuhb5dl 272 39 and and CC cord-324859-0yuhb5dl 272 40 67 67 CD cord-324859-0yuhb5dl 272 41 noncritical noncritical JJ cord-324859-0yuhb5dl 272 42 cases case NNS cord-324859-0yuhb5dl 272 43 of of IN cord-324859-0yuhb5dl 272 44 COVID-19 covid-19 CD cord-324859-0yuhb5dl 272 45 in in IN cord-324859-0yuhb5dl 272 46 Chengdu Chengdu NNP cord-324859-0yuhb5dl 272 47 Clinical clinical JJ cord-324859-0yuhb5dl 272 48 characteristics characteristic NNS cord-324859-0yuhb5dl 272 49 and and CC cord-324859-0yuhb5dl 272 50 prognosis prognosis NN cord-324859-0yuhb5dl 272 51 in in IN cord-324859-0yuhb5dl 272 52 cancer cancer NN cord-324859-0yuhb5dl 272 53 patients patient NNS cord-324859-0yuhb5dl 272 54 with with IN cord-324859-0yuhb5dl 272 55 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 272 56 : : : cord-324859-0yuhb5dl 272 57 a a DT cord-324859-0yuhb5dl 272 58 single single JJ cord-324859-0yuhb5dl 272 59 center center NN cord-324859-0yuhb5dl 272 60 's 's POS cord-324859-0yuhb5dl 272 61 retrospective retrospective JJ cord-324859-0yuhb5dl 272 62 study study NN cord-324859-0yuhb5dl 272 63 Epidemiological epidemiological JJ cord-324859-0yuhb5dl 272 64 and and CC cord-324859-0yuhb5dl 272 65 clinical clinical JJ cord-324859-0yuhb5dl 272 66 features feature NNS cord-324859-0yuhb5dl 272 67 of of IN cord-324859-0yuhb5dl 272 68 125 125 CD cord-324859-0yuhb5dl 272 69 hospitalized hospitalize VBN cord-324859-0yuhb5dl 272 70 patients patient NNS cord-324859-0yuhb5dl 272 71 with with IN cord-324859-0yuhb5dl 272 72 COVID-19 covid-19 CD cord-324859-0yuhb5dl 272 73 in in IN cord-324859-0yuhb5dl 272 74 Clinical clinical JJ cord-324859-0yuhb5dl 272 75 characteristics characteristic NNS cord-324859-0yuhb5dl 272 76 and and CC cord-324859-0yuhb5dl 272 77 outcomes outcome NNS cord-324859-0yuhb5dl 272 78 of of IN cord-324859-0yuhb5dl 272 79 older old JJR cord-324859-0yuhb5dl 272 80 patients patient NNS cord-324859-0yuhb5dl 272 81 with with IN cord-324859-0yuhb5dl 272 82 coronavirus coronavirus NN cord-324859-0yuhb5dl 272 83 disease disease NN cord-324859-0yuhb5dl 273 1 ): ): NNP cord-324859-0yuhb5dl 274 1 a a DT cord-324859-0yuhb5dl 274 2 single single RB cord-324859-0yuhb5dl 274 3 - - HYPH cord-324859-0yuhb5dl 274 4 centered centered JJ cord-324859-0yuhb5dl 274 5 , , , cord-324859-0yuhb5dl 274 6 retrospective retrospective JJ cord-324859-0yuhb5dl 274 7 study study NN cord-324859-0yuhb5dl 274 8 Clinical clinical JJ cord-324859-0yuhb5dl 274 9 characteristics characteristic NNS cord-324859-0yuhb5dl 274 10 of of IN cord-324859-0yuhb5dl 274 11 113 113 CD cord-324859-0yuhb5dl 274 12 deceased deceased JJ cord-324859-0yuhb5dl 274 13 patients patient NNS cord-324859-0yuhb5dl 274 14 with with IN cord-324859-0yuhb5dl 274 15 coronavirus coronavirus NN cord-324859-0yuhb5dl 274 16 disease disease NN cord-324859-0yuhb5dl 274 17 2019 2019 CD cord-324859-0yuhb5dl 274 18 : : : cord-324859-0yuhb5dl 274 19 retrospective retrospective JJ cord-324859-0yuhb5dl 274 20 study study NN cord-324859-0yuhb5dl 274 21 Clinical clinical JJ cord-324859-0yuhb5dl 274 22 characteristics characteristic NNS cord-324859-0yuhb5dl 274 23 of of IN cord-324859-0yuhb5dl 274 24 refractory refractory JJ cord-324859-0yuhb5dl 274 25 COVID-19 covid-19 JJ cord-324859-0yuhb5dl 274 26 pneumonia pneumonia NN cord-324859-0yuhb5dl 274 27 in in IN cord-324859-0yuhb5dl 274 28 Wuhan Wuhan NNP cord-324859-0yuhb5dl 274 29 , , , cord-324859-0yuhb5dl 274 30 China China NNP cord-324859-0yuhb5dl 274 31 Clinical Clinical NNP cord-324859-0yuhb5dl 274 32 and and CC cord-324859-0yuhb5dl 274 33 autoimmune autoimmune JJ cord-324859-0yuhb5dl 274 34 characteristics characteristic NNS cord-324859-0yuhb5dl 274 35 of of IN cord-324859-0yuhb5dl 274 36 severe severe JJ cord-324859-0yuhb5dl 274 37 and and CC cord-324859-0yuhb5dl 274 38 critical critical JJ cord-324859-0yuhb5dl 274 39 cases case NNS cord-324859-0yuhb5dl 274 40 of of IN cord-324859-0yuhb5dl 274 41 COVID-19 covid-19 JJ cord-324859-0yuhb5dl 274 42 Relationships Relationships NNPS cord-324859-0yuhb5dl 274 43 among among IN cord-324859-0yuhb5dl 274 44 lymphocyte lymphocyte NN cord-324859-0yuhb5dl 274 45 subsets subset NNS cord-324859-0yuhb5dl 274 46 , , , cord-324859-0yuhb5dl 274 47 cytokines cytokine NNS cord-324859-0yuhb5dl 274 48 , , , cord-324859-0yuhb5dl 274 49 and and CC cord-324859-0yuhb5dl 274 50 the the DT cord-324859-0yuhb5dl 274 51 pulmonary pulmonary JJ cord-324859-0yuhb5dl 274 52 inflammation inflammation NN cord-324859-0yuhb5dl 274 53 index index NN cord-324859-0yuhb5dl 274 54 in in IN cord-324859-0yuhb5dl 274 55 coronavirus coronavirus NN cord-324859-0yuhb5dl 274 56 ( ( -LRB- cord-324859-0yuhb5dl 274 57 COVID-19 covid-19 VB cord-324859-0yuhb5dl 274 58 ) ) -RRB- cord-324859-0yuhb5dl 274 59 infected infect VBN cord-324859-0yuhb5dl 274 60 patients patient NNS cord-324859-0yuhb5dl 274 61 Detectable detectable JJ cord-324859-0yuhb5dl 274 62 serum serum NN cord-324859-0yuhb5dl 274 63 severe severe JJ cord-324859-0yuhb5dl 274 64 acute acute JJ cord-324859-0yuhb5dl 274 65 respiratory respiratory JJ cord-324859-0yuhb5dl 274 66 syndrome syndrome NN cord-324859-0yuhb5dl 274 67 coronavirus coronavirus NN cord-324859-0yuhb5dl 274 68 2 2 CD cord-324859-0yuhb5dl 274 69 viral viral JJ cord-324859-0yuhb5dl 274 70 load load NN cord-324859-0yuhb5dl 274 71 ( ( -LRB- cord-324859-0yuhb5dl 274 72 RNAemia RNAemia NNP cord-324859-0yuhb5dl 274 73 ) ) -RRB- cord-324859-0yuhb5dl 274 74 is be VBZ cord-324859-0yuhb5dl 274 75 closely closely RB cord-324859-0yuhb5dl 274 76 correlated correlate VBN cord-324859-0yuhb5dl 274 77 with with IN cord-324859-0yuhb5dl 274 78 drastically drastically RB cord-324859-0yuhb5dl 274 79 elevated elevate VBN cord-324859-0yuhb5dl 274 80 interleukin interleukin NN cord-324859-0yuhb5dl 274 81 6 6 CD cord-324859-0yuhb5dl 274 82 level level NN cord-324859-0yuhb5dl 274 83 in in IN cord-324859-0yuhb5dl 274 84 critically critically RB cord-324859-0yuhb5dl 274 85 ill ill JJ cord-324859-0yuhb5dl 274 86 patients patient NNS cord-324859-0yuhb5dl 274 87 with with IN cord-324859-0yuhb5dl 274 88 coronavirus coronavirus NN cord-324859-0yuhb5dl 274 89 disease disease NN cord-324859-0yuhb5dl 274 90 2019 2019 CD cord-324859-0yuhb5dl 274 91 Diagnostic diagnostic JJ cord-324859-0yuhb5dl 274 92 utility utility NN cord-324859-0yuhb5dl 274 93 of of IN cord-324859-0yuhb5dl 274 94 clinical clinical JJ cord-324859-0yuhb5dl 274 95 laboratory laboratory NN cord-324859-0yuhb5dl 274 96 data datum NNS cord-324859-0yuhb5dl 274 97 determinations determination NNS cord-324859-0yuhb5dl 274 98 for for IN cord-324859-0yuhb5dl 274 99 patients patient NNS cord-324859-0yuhb5dl 274 100 with with IN cord-324859-0yuhb5dl 274 101 the the DT cord-324859-0yuhb5dl 274 102 severe severe JJ cord-324859-0yuhb5dl 274 103 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 274 104 Clinical clinical JJ cord-324859-0yuhb5dl 274 105 features feature NNS cord-324859-0yuhb5dl 274 106 of of IN cord-324859-0yuhb5dl 274 107 69 69 CD cord-324859-0yuhb5dl 274 108 cases case NNS cord-324859-0yuhb5dl 274 109 with with IN cord-324859-0yuhb5dl 274 110 coronavirus coronavirus NN cord-324859-0yuhb5dl 274 111 disease disease NN cord-324859-0yuhb5dl 274 112 2019 2019 CD cord-324859-0yuhb5dl 274 113 in in IN cord-324859-0yuhb5dl 274 114 Wuhan Wuhan NNP cord-324859-0yuhb5dl 274 115 , , , cord-324859-0yuhb5dl 274 116 China China NNP cord-324859-0yuhb5dl 274 117 Dysregulation Dysregulation NNP cord-324859-0yuhb5dl 274 118 of of IN cord-324859-0yuhb5dl 274 119 immune immune JJ cord-324859-0yuhb5dl 274 120 response response NN cord-324859-0yuhb5dl 274 121 in in IN cord-324859-0yuhb5dl 274 122 patients patient NNS cord-324859-0yuhb5dl 274 123 with with IN cord-324859-0yuhb5dl 274 124 coronavirus coronavirus NN cord-324859-0yuhb5dl 274 125 2019 2019 CD cord-324859-0yuhb5dl 274 126 ( ( -LRB- cord-324859-0yuhb5dl 274 127 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 274 128 ) ) -RRB- cord-324859-0yuhb5dl 274 129 in in IN cord-324859-0yuhb5dl 274 130 Wuhan Wuhan NNP cord-324859-0yuhb5dl 274 131 , , , cord-324859-0yuhb5dl 274 132 China China NNP cord-324859-0yuhb5dl 274 133 Tocilizumab Tocilizumab NNP cord-324859-0yuhb5dl 274 134 treatment treatment NN cord-324859-0yuhb5dl 274 135 in in IN cord-324859-0yuhb5dl 274 136 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 274 137 : : : cord-324859-0yuhb5dl 274 138 a a DT cord-324859-0yuhb5dl 274 139 single single JJ cord-324859-0yuhb5dl 274 140 center center NN cord-324859-0yuhb5dl 274 141 experience experience NN cord-324859-0yuhb5dl 274 142 Coronavirus Coronavirus NNP cord-324859-0yuhb5dl 274 143 disease disease NN cord-324859-0yuhb5dl 274 144 2019 2019 CD cord-324859-0yuhb5dl 274 145 in in IN cord-324859-0yuhb5dl 274 146 elderly elderly JJ cord-324859-0yuhb5dl 274 147 patients patient NNS cord-324859-0yuhb5dl 274 148 : : : cord-324859-0yuhb5dl 274 149 Characteristics characteristic NNS cord-324859-0yuhb5dl 274 150 and and CC cord-324859-0yuhb5dl 274 151 prognostic prognostic JJ cord-324859-0yuhb5dl 274 152 factors factor NNS cord-324859-0yuhb5dl 274 153 based base VBN cord-324859-0yuhb5dl 274 154 on on IN cord-324859-0yuhb5dl 274 155 4-week 4-week CD cord-324859-0yuhb5dl 274 156 follow follow NN cord-324859-0yuhb5dl 274 157 - - HYPH cord-324859-0yuhb5dl 274 158 up up RP cord-324859-0yuhb5dl 274 159 Clinical clinical JJ cord-324859-0yuhb5dl 274 160 predictors predictor NNS cord-324859-0yuhb5dl 274 161 of of IN cord-324859-0yuhb5dl 274 162 mortality mortality NN cord-324859-0yuhb5dl 274 163 due due IN cord-324859-0yuhb5dl 274 164 to to IN cord-324859-0yuhb5dl 274 165 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 274 166 based base VBN cord-324859-0yuhb5dl 274 167 on on IN cord-324859-0yuhb5dl 274 168 an an DT cord-324859-0yuhb5dl 274 169 analysis analysis NN cord-324859-0yuhb5dl 274 170 of of IN cord-324859-0yuhb5dl 274 171 data datum NNS cord-324859-0yuhb5dl 274 172 of of IN cord-324859-0yuhb5dl 274 173 150 150 CD cord-324859-0yuhb5dl 274 174 patients patient NNS cord-324859-0yuhb5dl 274 175 from from IN cord-324859-0yuhb5dl 274 176 Wuhan Wuhan NNP cord-324859-0yuhb5dl 274 177 , , , cord-324859-0yuhb5dl 274 178 China China NNP cord-324859-0yuhb5dl 274 179 COVID-19 covid-19 VBP cord-324859-0yuhb5dl 274 180 with with IN cord-324859-0yuhb5dl 274 181 different different JJ cord-324859-0yuhb5dl 274 182 severities severity NNS cord-324859-0yuhb5dl 274 183 : : : cord-324859-0yuhb5dl 274 184 a a DT cord-324859-0yuhb5dl 274 185 multicenter multicenter JJ cord-324859-0yuhb5dl 274 186 study study NN cord-324859-0yuhb5dl 274 187 of of IN cord-324859-0yuhb5dl 274 188 clinical clinical JJ cord-324859-0yuhb5dl 274 189 features feature VBZ cord-324859-0yuhb5dl 274 190 Risk risk NN cord-324859-0yuhb5dl 274 191 factors factor NNS cord-324859-0yuhb5dl 274 192 associated associate VBN cord-324859-0yuhb5dl 274 193 with with IN cord-324859-0yuhb5dl 274 194 disease disease NN cord-324859-0yuhb5dl 274 195 progression progression NN cord-324859-0yuhb5dl 274 196 in in IN cord-324859-0yuhb5dl 274 197 a a DT cord-324859-0yuhb5dl 274 198 cohort cohort NN cord-324859-0yuhb5dl 274 199 of of IN cord-324859-0yuhb5dl 274 200 patients patient NNS cord-324859-0yuhb5dl 274 201 infected infect VBN cord-324859-0yuhb5dl 274 202 with with IN cord-324859-0yuhb5dl 274 203 the the DT cord-324859-0yuhb5dl 274 204 2019 2019 CD cord-324859-0yuhb5dl 274 205 novel novel NN cord-324859-0yuhb5dl 274 206 coronavirus coronavirus NN cord-324859-0yuhb5dl 275 1 The the DT cord-324859-0yuhb5dl 275 2 correlation correlation NN cord-324859-0yuhb5dl 275 3 between between IN cord-324859-0yuhb5dl 275 4 viral viral JJ cord-324859-0yuhb5dl 275 5 clearance clearance NN cord-324859-0yuhb5dl 275 6 and and CC cord-324859-0yuhb5dl 275 7 biochemical biochemical JJ cord-324859-0yuhb5dl 275 8 outcomes outcome NNS cord-324859-0yuhb5dl 275 9 of of IN cord-324859-0yuhb5dl 275 10 94 94 CD cord-324859-0yuhb5dl 275 11 COVID-19 covid-19 CD cord-324859-0yuhb5dl 275 12 infected infected JJ cord-324859-0yuhb5dl 275 13 discharged discharge VBN cord-324859-0yuhb5dl 275 14 patients patient NNS cord-324859-0yuhb5dl 275 15 Clinical clinical JJ cord-324859-0yuhb5dl 275 16 characteristics characteristic NNS cord-324859-0yuhb5dl 275 17 of of IN cord-324859-0yuhb5dl 275 18 SARS SARS NNP cord-324859-0yuhb5dl 275 19 - - HYPH cord-324859-0yuhb5dl 275 20 CoV-2 CoV-2 NNP cord-324859-0yuhb5dl 275 21 pneumonia pneumonia NN cord-324859-0yuhb5dl 275 22 compared compare VBN cord-324859-0yuhb5dl 275 23 to to IN cord-324859-0yuhb5dl 275 24 controls control NNS cord-324859-0yuhb5dl 275 25 in in IN cord-324859-0yuhb5dl 275 26 Chinese chinese JJ cord-324859-0yuhb5dl 275 27 Han Han NNP cord-324859-0yuhb5dl 275 28 Population Population NNP cord-324859-0yuhb5dl 275 29 . . . cord-324859-0yuhb5dl 276 1 medRxiv medRxiv NFP cord-324859-0yuhb5dl 276 2 Metabolic metabolic JJ cord-324859-0yuhb5dl 276 3 disturbances disturbance NNS cord-324859-0yuhb5dl 276 4 and and CC cord-324859-0yuhb5dl 276 5 inflammatory inflammatory JJ cord-324859-0yuhb5dl 276 6 dysfunction dysfunction NN cord-324859-0yuhb5dl 276 7 predict predict VBP cord-324859-0yuhb5dl 276 8 severity severity NN cord-324859-0yuhb5dl 276 9 of of IN cord-324859-0yuhb5dl 276 10 coronavirus coronavirus NN cord-324859-0yuhb5dl 276 11 disease disease NN cord-324859-0yuhb5dl 276 12 2019 2019 CD cord-324859-0yuhb5dl 276 13 ( ( -LRB- cord-324859-0yuhb5dl 276 14 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 276 15 ) ) -RRB- cord-324859-0yuhb5dl 276 16 : : : cord-324859-0yuhb5dl 276 17 a a DT cord-324859-0yuhb5dl 276 18 retrospective retrospective JJ cord-324859-0yuhb5dl 276 19 study study NN cord-324859-0yuhb5dl 276 20 Potential potential JJ cord-324859-0yuhb5dl 276 21 factors factor NNS cord-324859-0yuhb5dl 276 22 for for IN cord-324859-0yuhb5dl 276 23 prediction prediction NN cord-324859-0yuhb5dl 276 24 of of IN cord-324859-0yuhb5dl 276 25 disease disease NN cord-324859-0yuhb5dl 276 26 severity severity NN cord-324859-0yuhb5dl 276 27 of of IN cord-324859-0yuhb5dl 276 28 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 276 29 patients patient NNS cord-324859-0yuhb5dl 276 30 Epidemiological epidemiological JJ cord-324859-0yuhb5dl 276 31 and and CC cord-324859-0yuhb5dl 276 32 clinical clinical JJ cord-324859-0yuhb5dl 276 33 features feature NNS cord-324859-0yuhb5dl 276 34 of of IN cord-324859-0yuhb5dl 276 35 COVID-19 covid-19 JJ cord-324859-0yuhb5dl 276 36 patients patient NNS cord-324859-0yuhb5dl 276 37 with with IN cord-324859-0yuhb5dl 276 38 and and CC cord-324859-0yuhb5dl 276 39 without without IN cord-324859-0yuhb5dl 276 40 pneumonia pneumonia NN cord-324859-0yuhb5dl 276 41 in in IN cord-324859-0yuhb5dl 276 42 Beijing Beijing NNP cord-324859-0yuhb5dl 276 43 , , , cord-324859-0yuhb5dl 276 44 China China NNP cord-324859-0yuhb5dl 276 45 . . . cord-324859-0yuhb5dl 277 1 medRxiv medRxiv NNS cord-324859-0yuhb5dl 277 2 Dynamic dynamic JJ cord-324859-0yuhb5dl 277 3 profile profile NN cord-324859-0yuhb5dl 277 4 of of IN cord-324859-0yuhb5dl 277 5 severe severe JJ cord-324859-0yuhb5dl 277 6 or or CC cord-324859-0yuhb5dl 277 7 critical critical JJ cord-324859-0yuhb5dl 277 8 COVID-19 covid-19 JJ cord-324859-0yuhb5dl 277 9 cases case NNS cord-324859-0yuhb5dl 277 10 . . . cord-324859-0yuhb5dl 278 1 medRxiv medRxiv NNS cord-324859-0yuhb5dl 278 2 Clinical clinical JJ cord-324859-0yuhb5dl 278 3 characteristics characteristic NNS cord-324859-0yuhb5dl 278 4 of of IN cord-324859-0yuhb5dl 278 5 51 51 CD cord-324859-0yuhb5dl 278 6 patients patient NNS cord-324859-0yuhb5dl 278 7 discharged discharge VBN cord-324859-0yuhb5dl 278 8 from from IN cord-324859-0yuhb5dl 278 9 hospital hospital NN cord-324859-0yuhb5dl 278 10 with with IN cord-324859-0yuhb5dl 278 11 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 278 12 in in IN cord-324859-0yuhb5dl 278 13 Chongqing Chongqing NNP cord-324859-0yuhb5dl 278 14 , , , cord-324859-0yuhb5dl 278 15 China China NNP cord-324859-0yuhb5dl 278 16 . . . cord-324859-0yuhb5dl 279 1 medRxiv medRxiv NNS cord-324859-0yuhb5dl 279 2 COVID-19 covid-19 VBP cord-324859-0yuhb5dl 279 3 in in IN cord-324859-0yuhb5dl 279 4 a a DT cord-324859-0yuhb5dl 279 5 designated designate VBN cord-324859-0yuhb5dl 279 6 infectious infectious JJ cord-324859-0yuhb5dl 279 7 diseases disease NNS cord-324859-0yuhb5dl 279 8 hospital hospital NN cord-324859-0yuhb5dl 279 9 outside outside IN cord-324859-0yuhb5dl 279 10 Hubei Hubei NNP cord-324859-0yuhb5dl 279 11 Province Province NNP cord-324859-0yuhb5dl 279 12 , , , cord-324859-0yuhb5dl 279 13 China China NNP cord-324859-0yuhb5dl 279 14 . . . cord-324859-0yuhb5dl 280 1 medRxiv medRxiv NNS cord-324859-0yuhb5dl 280 2 Virologic Virologic NNP cord-324859-0yuhb5dl 280 3 and and CC cord-324859-0yuhb5dl 280 4 clinical clinical JJ cord-324859-0yuhb5dl 280 5 characteristics characteristic NNS cord-324859-0yuhb5dl 280 6 for for IN cord-324859-0yuhb5dl 280 7 prognosis prognosis NN cord-324859-0yuhb5dl 280 8 of of IN cord-324859-0yuhb5dl 280 9 severe severe JJ cord-324859-0yuhb5dl 280 10 COVID-19 covid-19 NN cord-324859-0yuhb5dl 280 11 : : : cord-324859-0yuhb5dl 280 12 a a DT cord-324859-0yuhb5dl 280 13 retrospective retrospective JJ cord-324859-0yuhb5dl 280 14 observational observational JJ cord-324859-0yuhb5dl 280 15 study study NN cord-324859-0yuhb5dl 280 16 in in IN cord-324859-0yuhb5dl 280 17 Wuhan Wuhan NNP cord-324859-0yuhb5dl 280 18 , , , cord-324859-0yuhb5dl 280 19 China China NNP cord-324859-0yuhb5dl 280 20 . . . cord-324859-0yuhb5dl 281 1 medRxiv medRxiv NNS cord-324859-0yuhb5dl 281 2 Down down RB cord-324859-0yuhb5dl 281 3 - - HYPH cord-324859-0yuhb5dl 281 4 regulated regulate VBN cord-324859-0yuhb5dl 281 5 gene gene NN cord-324859-0yuhb5dl 281 6 expression expression NN cord-324859-0yuhb5dl 281 7 spectrum spectrum NN cord-324859-0yuhb5dl 281 8 and and CC cord-324859-0yuhb5dl 281 9 immune immune JJ cord-324859-0yuhb5dl 281 10 responses response NNS cord-324859-0yuhb5dl 281 11 changed change VBD cord-324859-0yuhb5dl 281 12 during during IN cord-324859-0yuhb5dl 281 13 the the DT cord-324859-0yuhb5dl 281 14 disease disease NN cord-324859-0yuhb5dl 281 15 COVID-19 covid-19 CD cord-324859-0yuhb5dl 281 16 patients patient NNS cord-324859-0yuhb5dl 281 17 Longitudinal longitudinal JJ cord-324859-0yuhb5dl 281 18 characteristics characteristic NNS cord-324859-0yuhb5dl 281 19 of of IN cord-324859-0yuhb5dl 281 20 lymphocyte lymphocyte NN cord-324859-0yuhb5dl 281 21 responses response NNS cord-324859-0yuhb5dl 281 22 and and CC cord-324859-0yuhb5dl 281 23 cytokine cytokine NN cord-324859-0yuhb5dl 281 24 profiles profile NNS cord-324859-0yuhb5dl 281 25 in in IN cord-324859-0yuhb5dl 281 26 the the DT cord-324859-0yuhb5dl 281 27 peripheral peripheral JJ cord-324859-0yuhb5dl 281 28 blood blood NN cord-324859-0yuhb5dl 281 29 of of IN cord-324859-0yuhb5dl 281 30 SARS SARS NNP cord-324859-0yuhb5dl 281 31 - - HYPH cord-324859-0yuhb5dl 281 32 CoV-2 CoV-2 NNP cord-324859-0yuhb5dl 281 33 infected infect VBD cord-324859-0yuhb5dl 281 34 patients patient NNS cord-324859-0yuhb5dl 281 35 Correlation correlation NN cord-324859-0yuhb5dl 281 36 between between IN cord-324859-0yuhb5dl 281 37 relative relative JJ cord-324859-0yuhb5dl 281 38 nasopharyngeal nasopharyngeal JJ cord-324859-0yuhb5dl 281 39 virus virus NN cord-324859-0yuhb5dl 281 40 RNA RNA NNP cord-324859-0yuhb5dl 281 41 load load NN cord-324859-0yuhb5dl 281 42 and and CC cord-324859-0yuhb5dl 281 43 lymphocyte lymphocyte NN cord-324859-0yuhb5dl 281 44 count count NN cord-324859-0yuhb5dl 281 45 disease disease NN cord-324859-0yuhb5dl 281 46 severity severity NN cord-324859-0yuhb5dl 281 47 in in IN cord-324859-0yuhb5dl 281 48 patients patient NNS cord-324859-0yuhb5dl 281 49 with with IN cord-324859-0yuhb5dl 281 50 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 281 51 Retrospective Retrospective NNP cord-324859-0yuhb5dl 281 52 analysis analysis NN cord-324859-0yuhb5dl 281 53 of of IN cord-324859-0yuhb5dl 281 54 laboratory laboratory NN cord-324859-0yuhb5dl 281 55 testing testing NN cord-324859-0yuhb5dl 281 56 in in IN cord-324859-0yuhb5dl 281 57 54 54 CD cord-324859-0yuhb5dl 281 58 patients patient NNS cord-324859-0yuhb5dl 281 59 with with IN cord-324859-0yuhb5dl 281 60 severe severe JJ cord-324859-0yuhb5dl 281 61 - - HYPH cord-324859-0yuhb5dl 281 62 or or CC cord-324859-0yuhb5dl 281 63 critical critical JJ cord-324859-0yuhb5dl 281 64 - - HYPH cord-324859-0yuhb5dl 281 65 type type NN cord-324859-0yuhb5dl 281 66 2019 2019 CD cord-324859-0yuhb5dl 281 67 novel novel NN cord-324859-0yuhb5dl 281 68 coronavirus coronavirus NN cord-324859-0yuhb5dl 281 69 pneumonia pneumonia NN cord-324859-0yuhb5dl 281 70 Suppressed suppress VBD cord-324859-0yuhb5dl 281 71 T T NNP cord-324859-0yuhb5dl 281 72 cell cell NN cord-324859-0yuhb5dl 281 73 - - HYPH cord-324859-0yuhb5dl 281 74 mediated mediate VBN cord-324859-0yuhb5dl 281 75 immunity immunity NN cord-324859-0yuhb5dl 281 76 in in IN cord-324859-0yuhb5dl 281 77 patients patient NNS cord-324859-0yuhb5dl 281 78 with with IN cord-324859-0yuhb5dl 281 79 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 281 80 : : : cord-324859-0yuhb5dl 281 81 a a DT cord-324859-0yuhb5dl 281 82 clinical clinical JJ cord-324859-0yuhb5dl 281 83 retrospective retrospective JJ cord-324859-0yuhb5dl 281 84 study study NN cord-324859-0yuhb5dl 281 85 in in IN cord-324859-0yuhb5dl 281 86 Wuhan Wuhan NNP cord-324859-0yuhb5dl 281 87 Risk Risk NNP cord-324859-0yuhb5dl 281 88 - - HYPH cord-324859-0yuhb5dl 281 89 adapted adapt VBN cord-324859-0yuhb5dl 281 90 treatment treatment NN cord-324859-0yuhb5dl 281 91 strategy strategy NN cord-324859-0yuhb5dl 281 92 for for IN cord-324859-0yuhb5dl 281 93 COVID-19 covid-19 JJ cord-324859-0yuhb5dl 281 94 patients patient NNS cord-324859-0yuhb5dl 281 95 Elevated elevated JJ cord-324859-0yuhb5dl 281 96 exhaustion exhaustion NN cord-324859-0yuhb5dl 281 97 levels level NNS cord-324859-0yuhb5dl 281 98 and and CC cord-324859-0yuhb5dl 281 99 reduced reduce VBN cord-324859-0yuhb5dl 281 100 functional functional JJ cord-324859-0yuhb5dl 281 101 diversity diversity NN cord-324859-0yuhb5dl 281 102 of of IN cord-324859-0yuhb5dl 281 103 T t NN cord-324859-0yuhb5dl 281 104 cells cell NNS cord-324859-0yuhb5dl 281 105 in in IN cord-324859-0yuhb5dl 281 106 peripheral peripheral JJ cord-324859-0yuhb5dl 281 107 blood blood NN cord-324859-0yuhb5dl 281 108 may may MD cord-324859-0yuhb5dl 281 109 predict predict VB cord-324859-0yuhb5dl 281 110 severe severe JJ cord-324859-0yuhb5dl 281 111 progression progression NN cord-324859-0yuhb5dl 281 112 in in IN cord-324859-0yuhb5dl 281 113 COVID-19 covid-19 JJ cord-324859-0yuhb5dl 281 114 patients patient NNS cord-324859-0yuhb5dl 281 115 Functional functional JJ cord-324859-0yuhb5dl 281 116 exhaustion exhaustion NN cord-324859-0yuhb5dl 281 117 of of IN cord-324859-0yuhb5dl 281 118 antiviral antiviral JJ cord-324859-0yuhb5dl 281 119 lymphocytes lymphocyte NNS cord-324859-0yuhb5dl 281 120 in in IN cord-324859-0yuhb5dl 281 121 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 281 122 patients patient NNS cord-324859-0yuhb5dl 281 123 Risk Risk NNP cord-324859-0yuhb5dl 281 124 factors factor NNS cord-324859-0yuhb5dl 281 125 associated associate VBN cord-324859-0yuhb5dl 281 126 with with IN cord-324859-0yuhb5dl 281 127 acute acute JJ cord-324859-0yuhb5dl 281 128 respiratory respiratory JJ cord-324859-0yuhb5dl 281 129 distress distress NN cord-324859-0yuhb5dl 281 130 syndrome syndrome NN cord-324859-0yuhb5dl 281 131 and and CC cord-324859-0yuhb5dl 281 132 death death NN cord-324859-0yuhb5dl 281 133 in in IN cord-324859-0yuhb5dl 281 134 patients patient NNS cord-324859-0yuhb5dl 281 135 with with IN cord-324859-0yuhb5dl 281 136 coronavirus coronavirus NN cord-324859-0yuhb5dl 281 137 disease disease NN cord-324859-0yuhb5dl 281 138 2019 2019 CD cord-324859-0yuhb5dl 281 139 pneumonia pneumonia NN cord-324859-0yuhb5dl 281 140 in in IN cord-324859-0yuhb5dl 281 141 Wuhan Wuhan NNP cord-324859-0yuhb5dl 281 142 , , , cord-324859-0yuhb5dl 281 143 China China NNP cord-324859-0yuhb5dl 281 144 Risk risk NN cord-324859-0yuhb5dl 281 145 factors factor NNS cord-324859-0yuhb5dl 281 146 for for IN cord-324859-0yuhb5dl 281 147 severity severity NN cord-324859-0yuhb5dl 281 148 and and CC cord-324859-0yuhb5dl 281 149 mortality mortality NN cord-324859-0yuhb5dl 281 150 in in IN cord-324859-0yuhb5dl 281 151 adult adult NN cord-324859-0yuhb5dl 281 152 COVID-19 covid-19 JJ cord-324859-0yuhb5dl 281 153 inpatients inpatient NNS cord-324859-0yuhb5dl 281 154 in in IN cord-324859-0yuhb5dl 281 155 Wuhan Wuhan NNP cord-324859-0yuhb5dl 281 156 Clinical Clinical NNP cord-324859-0yuhb5dl 281 157 course course NN cord-324859-0yuhb5dl 281 158 and and CC cord-324859-0yuhb5dl 281 159 risk risk NN cord-324859-0yuhb5dl 281 160 factors factor NNS cord-324859-0yuhb5dl 281 161 for for IN cord-324859-0yuhb5dl 281 162 mortality mortality NN cord-324859-0yuhb5dl 281 163 of of IN cord-324859-0yuhb5dl 281 164 adult adult NN cord-324859-0yuhb5dl 281 165 inpatients inpatient NNS cord-324859-0yuhb5dl 281 166 with with IN cord-324859-0yuhb5dl 281 167 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 281 168 in in IN cord-324859-0yuhb5dl 281 169 Wuhan Wuhan NNP cord-324859-0yuhb5dl 281 170 , , , cord-324859-0yuhb5dl 281 171 China China NNP cord-324859-0yuhb5dl 281 172 : : : cord-324859-0yuhb5dl 281 173 a a DT cord-324859-0yuhb5dl 281 174 retrospective retrospective JJ cord-324859-0yuhb5dl 281 175 cohort cohort NN cord-324859-0yuhb5dl 281 176 study study NN cord-324859-0yuhb5dl 282 1 Heart heart NN cord-324859-0yuhb5dl 282 2 injury injury NN cord-324859-0yuhb5dl 282 3 signs sign NNS cord-324859-0yuhb5dl 282 4 are be VBP cord-324859-0yuhb5dl 282 5 associated associate VBN cord-324859-0yuhb5dl 282 6 with with IN cord-324859-0yuhb5dl 282 7 higher high JJR cord-324859-0yuhb5dl 282 8 and and CC cord-324859-0yuhb5dl 282 9 earlier early JJR cord-324859-0yuhb5dl 282 10 mortality mortality NN cord-324859-0yuhb5dl 282 11 in in IN cord-324859-0yuhb5dl 282 12 coronavirus coronavirus NN cord-324859-0yuhb5dl 282 13 disease disease NN cord-324859-0yuhb5dl 282 14 Prognostic prognostic JJ cord-324859-0yuhb5dl 282 15 value value NN cord-324859-0yuhb5dl 282 16 of of IN cord-324859-0yuhb5dl 282 17 interleukin-6 interleukin-6 NNP cord-324859-0yuhb5dl 282 18 , , , cord-324859-0yuhb5dl 282 19 C C NNP cord-324859-0yuhb5dl 282 20 - - HYPH cord-324859-0yuhb5dl 282 21 reactive reactive JJ cord-324859-0yuhb5dl 282 22 protein protein NN cord-324859-0yuhb5dl 282 23 , , , cord-324859-0yuhb5dl 282 24 and and CC cord-324859-0yuhb5dl 282 25 procalcitonin procalcitonin NNS cord-324859-0yuhb5dl 282 26 in in IN cord-324859-0yuhb5dl 282 27 patients patient NNS cord-324859-0yuhb5dl 282 28 with with IN cord-324859-0yuhb5dl 282 29 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 283 1 Can Can MD cord-324859-0yuhb5dl 283 2 we -PRON- PRP cord-324859-0yuhb5dl 283 3 use use VB cord-324859-0yuhb5dl 283 4 interleukin-6 interleukin-6 NNP cord-324859-0yuhb5dl 283 5 ( ( -LRB- cord-324859-0yuhb5dl 283 6 IL-6 IL-6 NNP cord-324859-0yuhb5dl 283 7 ) ) -RRB- cord-324859-0yuhb5dl 283 8 blockade blockade NN cord-324859-0yuhb5dl 283 9 for for IN cord-324859-0yuhb5dl 283 10 coronavirus coronavirus NN cord-324859-0yuhb5dl 283 11 disease disease NN cord-324859-0yuhb5dl 283 12 2019 2019 CD cord-324859-0yuhb5dl 283 13 ( ( -LRB- cord-324859-0yuhb5dl 283 14 COVID-19)-induced covid-19)-induce VBN cord-324859-0yuhb5dl 283 15 cytokine cytokine NN cord-324859-0yuhb5dl 283 16 release release NN cord-324859-0yuhb5dl 283 17 syndrome syndrome NN cord-324859-0yuhb5dl 283 18 ( ( -LRB- cord-324859-0yuhb5dl 283 19 CRS CRS NNP cord-324859-0yuhb5dl 283 20 ) ) -RRB- cord-324859-0yuhb5dl 283 21 ? ? . cord-324859-0yuhb5dl 284 1 Genomic genomic JJ cord-324859-0yuhb5dl 284 2 characterisation characterisation NN cord-324859-0yuhb5dl 284 3 and and CC cord-324859-0yuhb5dl 284 4 epidemiology epidemiology NN cord-324859-0yuhb5dl 284 5 of of IN cord-324859-0yuhb5dl 284 6 2019 2019 CD cord-324859-0yuhb5dl 284 7 novel novel JJ cord-324859-0yuhb5dl 284 8 coronavirus coronavirus NN cord-324859-0yuhb5dl 284 9 : : : cord-324859-0yuhb5dl 284 10 implications implication NNS cord-324859-0yuhb5dl 284 11 for for IN cord-324859-0yuhb5dl 284 12 virus virus NN cord-324859-0yuhb5dl 284 13 origins origin NNS cord-324859-0yuhb5dl 284 14 and and CC cord-324859-0yuhb5dl 284 15 receptor receptor NN cord-324859-0yuhb5dl 285 1 binding bind VBG cord-324859-0yuhb5dl 285 2 Dysregulated Dysregulated NNP cord-324859-0yuhb5dl 285 3 type type NN cord-324859-0yuhb5dl 286 1 I -PRON- PRP cord-324859-0yuhb5dl 286 2 interferon interferon VBD cord-324859-0yuhb5dl 286 3 and and CC cord-324859-0yuhb5dl 286 4 inflammatory inflammatory JJ cord-324859-0yuhb5dl 286 5 monocyte monocyte JJ cord-324859-0yuhb5dl 286 6 - - HYPH cord-324859-0yuhb5dl 286 7 macrophage macrophage NN cord-324859-0yuhb5dl 286 8 responses response NNS cord-324859-0yuhb5dl 286 9 cause cause VBP cord-324859-0yuhb5dl 286 10 lethal lethal JJ cord-324859-0yuhb5dl 286 11 pneumonia pneumonia NN cord-324859-0yuhb5dl 286 12 in in IN cord-324859-0yuhb5dl 286 13 SARS SARS NNP cord-324859-0yuhb5dl 286 14 - - HYPH cord-324859-0yuhb5dl 286 15 CoV CoV NNP cord-324859-0yuhb5dl 286 16 - - HYPH cord-324859-0yuhb5dl 286 17 infected infect VBN cord-324859-0yuhb5dl 286 18 mice mouse NNS cord-324859-0yuhb5dl 286 19 Imbalanced imbalanced JJ cord-324859-0yuhb5dl 286 20 host host NN cord-324859-0yuhb5dl 286 21 response response NN cord-324859-0yuhb5dl 286 22 to to IN cord-324859-0yuhb5dl 286 23 SARS SARS NNP cord-324859-0yuhb5dl 286 24 - - HYPH cord-324859-0yuhb5dl 286 25 CoV-2 CoV-2 NNP cord-324859-0yuhb5dl 286 26 drives drive VBZ cord-324859-0yuhb5dl 286 27 development development NN cord-324859-0yuhb5dl 286 28 of of IN cord-324859-0yuhb5dl 286 29 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 287 1 Should Should MD cord-324859-0yuhb5dl 287 2 we -PRON- PRP cord-324859-0yuhb5dl 287 3 stimulate stimulate VB cord-324859-0yuhb5dl 287 4 or or CC cord-324859-0yuhb5dl 287 5 suppress suppress VB cord-324859-0yuhb5dl 287 6 immune immune JJ cord-324859-0yuhb5dl 287 7 responses response NNS cord-324859-0yuhb5dl 287 8 in in IN cord-324859-0yuhb5dl 287 9 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 287 10 ? ? . cord-324859-0yuhb5dl 288 1 Cytokine cytokine NN cord-324859-0yuhb5dl 288 2 and and CC cord-324859-0yuhb5dl 288 3 anti anti JJ cord-324859-0yuhb5dl 288 4 - - JJ cord-324859-0yuhb5dl 288 5 cytokine cytokine JJ cord-324859-0yuhb5dl 288 6 interventions intervention NNS cord-324859-0yuhb5dl 288 7 Induction Induction NNP cord-324859-0yuhb5dl 288 8 of of IN cord-324859-0yuhb5dl 288 9 apoptosis apoptosis NN cord-324859-0yuhb5dl 288 10 by by IN cord-324859-0yuhb5dl 288 11 the the DT cord-324859-0yuhb5dl 288 12 severe severe JJ cord-324859-0yuhb5dl 288 13 acute acute JJ cord-324859-0yuhb5dl 288 14 respiratory respiratory JJ cord-324859-0yuhb5dl 288 15 syndrome syndrome NN cord-324859-0yuhb5dl 288 16 coronavirus coronavirus NN cord-324859-0yuhb5dl 288 17 7a 7a NN cord-324859-0yuhb5dl 288 18 protein protein NN cord-324859-0yuhb5dl 288 19 is be VBZ cord-324859-0yuhb5dl 288 20 dependent dependent JJ cord-324859-0yuhb5dl 288 21 on on IN cord-324859-0yuhb5dl 288 22 its -PRON- PRP$ cord-324859-0yuhb5dl 288 23 interaction interaction NN cord-324859-0yuhb5dl 288 24 with with IN cord-324859-0yuhb5dl 288 25 the the DT cord-324859-0yuhb5dl 288 26 Bcl Bcl NNP cord-324859-0yuhb5dl 288 27 - - HYPH cord-324859-0yuhb5dl 288 28 XL XL NNP cord-324859-0yuhb5dl 288 29 protein protein NN cord-324859-0yuhb5dl 288 30 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 288 31 , , , cord-324859-0yuhb5dl 288 32 cytokines cytokine NNS cord-324859-0yuhb5dl 288 33 and and CC cord-324859-0yuhb5dl 288 34 immunosuppression immunosuppression NN cord-324859-0yuhb5dl 288 35 : : : cord-324859-0yuhb5dl 289 1 what what WP cord-324859-0yuhb5dl 289 2 can can MD cord-324859-0yuhb5dl 289 3 we -PRON- PRP cord-324859-0yuhb5dl 289 4 learn learn VB cord-324859-0yuhb5dl 289 5 from from IN cord-324859-0yuhb5dl 289 6 severe severe JJ cord-324859-0yuhb5dl 289 7 acute acute JJ cord-324859-0yuhb5dl 289 8 respiratory respiratory JJ cord-324859-0yuhb5dl 289 9 syndrome syndrome NN cord-324859-0yuhb5dl 289 10 ? ? . cord-324859-0yuhb5dl 290 1 Pathogenic pathogenic JJ cord-324859-0yuhb5dl 290 2 human human JJ cord-324859-0yuhb5dl 290 3 coronavirus coronavirus NN cord-324859-0yuhb5dl 290 4 infections infection NNS cord-324859-0yuhb5dl 290 5 : : : cord-324859-0yuhb5dl 290 6 causes cause NNS cord-324859-0yuhb5dl 290 7 and and CC cord-324859-0yuhb5dl 290 8 consequences consequence NNS cord-324859-0yuhb5dl 290 9 of of IN cord-324859-0yuhb5dl 290 10 cytokine cytokine NN cord-324859-0yuhb5dl 290 11 storm storm NN cord-324859-0yuhb5dl 290 12 and and CC cord-324859-0yuhb5dl 290 13 immunopathology immunopathology NN cord-324859-0yuhb5dl 291 1 The the DT cord-324859-0yuhb5dl 291 2 immunology immunology NN cord-324859-0yuhb5dl 291 3 of of IN cord-324859-0yuhb5dl 291 4 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 291 5 : : : cord-324859-0yuhb5dl 291 6 is be VBZ cord-324859-0yuhb5dl 291 7 immune immune JJ cord-324859-0yuhb5dl 291 8 modulation modulation NN cord-324859-0yuhb5dl 291 9 an an DT cord-324859-0yuhb5dl 291 10 option option NN cord-324859-0yuhb5dl 291 11 for for IN cord-324859-0yuhb5dl 291 12 treatment treatment NN cord-324859-0yuhb5dl 291 13 ? ? . cord-324859-0yuhb5dl 292 1 Pathophysiological pathophysiological JJ cord-324859-0yuhb5dl 292 2 roles role NNS cord-324859-0yuhb5dl 292 3 of of IN cord-324859-0yuhb5dl 292 4 interleukin-8 interleukin-8 NNP cord-324859-0yuhb5dl 292 5 / / SYM cord-324859-0yuhb5dl 292 6 CXCL8 cxcl8 NN cord-324859-0yuhb5dl 292 7 in in IN cord-324859-0yuhb5dl 292 8 pulmonary pulmonary JJ cord-324859-0yuhb5dl 292 9 diseases disease NNS cord-324859-0yuhb5dl 292 10 Biomarkers Biomarkers NNPS cord-324859-0yuhb5dl 292 11 for for IN cord-324859-0yuhb5dl 292 12 the the DT cord-324859-0yuhb5dl 292 13 acute acute JJ cord-324859-0yuhb5dl 292 14 respiratory respiratory JJ cord-324859-0yuhb5dl 292 15 distress distress NN cord-324859-0yuhb5dl 292 16 syndrome syndrome NN cord-324859-0yuhb5dl 292 17 : : : cord-324859-0yuhb5dl 292 18 how how WRB cord-324859-0yuhb5dl 292 19 to to TO cord-324859-0yuhb5dl 292 20 make make VB cord-324859-0yuhb5dl 292 21 the the DT cord-324859-0yuhb5dl 292 22 diagnosis diagnosis NN cord-324859-0yuhb5dl 292 23 more more RBR cord-324859-0yuhb5dl 292 24 precise precise JJ cord-324859-0yuhb5dl 292 25 Lower lower RBR cord-324859-0yuhb5dl 292 26 tidal tidal JJ cord-324859-0yuhb5dl 292 27 volume volume NN cord-324859-0yuhb5dl 292 28 ventilation ventilation NN cord-324859-0yuhb5dl 292 29 and and CC cord-324859-0yuhb5dl 292 30 plasma plasma NN cord-324859-0yuhb5dl 292 31 cytokine cytokine NN cord-324859-0yuhb5dl 292 32 markers marker NNS cord-324859-0yuhb5dl 292 33 of of IN cord-324859-0yuhb5dl 292 34 inflammation inflammation NN cord-324859-0yuhb5dl 292 35 in in IN cord-324859-0yuhb5dl 292 36 patients patient NNS cord-324859-0yuhb5dl 292 37 with with IN cord-324859-0yuhb5dl 292 38 acute acute JJ cord-324859-0yuhb5dl 292 39 lung lung NN cord-324859-0yuhb5dl 292 40 injury injury NN cord-324859-0yuhb5dl 292 41 Reduction reduction NN cord-324859-0yuhb5dl 292 42 and and CC cord-324859-0yuhb5dl 292 43 functional functional JJ cord-324859-0yuhb5dl 292 44 exhaustion exhaustion NN cord-324859-0yuhb5dl 292 45 of of IN cord-324859-0yuhb5dl 292 46 T t NN cord-324859-0yuhb5dl 292 47 cells cell NNS cord-324859-0yuhb5dl 292 48 in in IN cord-324859-0yuhb5dl 292 49 patients patient NNS cord-324859-0yuhb5dl 292 50 T T NNP cord-324859-0yuhb5dl 292 51 cell cell NN cord-324859-0yuhb5dl 292 52 - - HYPH cord-324859-0yuhb5dl 292 53 mediated mediate VBN cord-324859-0yuhb5dl 292 54 immune immune JJ cord-324859-0yuhb5dl 292 55 response response NN cord-324859-0yuhb5dl 292 56 to to IN cord-324859-0yuhb5dl 292 57 respiratory respiratory JJ cord-324859-0yuhb5dl 292 58 coronaviruses coronaviruse NNS cord-324859-0yuhb5dl 293 1 Haematological Haematological NNP cord-324859-0yuhb5dl 293 2 manifestations manifestation NNS cord-324859-0yuhb5dl 293 3 in in IN cord-324859-0yuhb5dl 293 4 patients patient NNS cord-324859-0yuhb5dl 293 5 with with IN cord-324859-0yuhb5dl 293 6 severe severe JJ cord-324859-0yuhb5dl 293 7 acute acute JJ cord-324859-0yuhb5dl 293 8 respiratory respiratory JJ cord-324859-0yuhb5dl 293 9 syndrome syndrome NN cord-324859-0yuhb5dl 293 10 : : : cord-324859-0yuhb5dl 294 1 retrospective retrospective JJ cord-324859-0yuhb5dl 294 2 analysis analysis NNP cord-324859-0yuhb5dl 295 1 Rapid rapid JJ cord-324859-0yuhb5dl 295 2 loss loss NN cord-324859-0yuhb5dl 295 3 of of IN cord-324859-0yuhb5dl 295 4 both both DT cord-324859-0yuhb5dl 295 5 CD4 CD4 NNP cord-324859-0yuhb5dl 295 6 + + CC cord-324859-0yuhb5dl 295 7 and and CC cord-324859-0yuhb5dl 295 8 CD8 CD8 NNP cord-324859-0yuhb5dl 295 9 + + CC cord-324859-0yuhb5dl 295 10 T T NNP cord-324859-0yuhb5dl 295 11 lymphocyte lymphocyte NN cord-324859-0yuhb5dl 295 12 subsets subset NNS cord-324859-0yuhb5dl 295 13 during during IN cord-324859-0yuhb5dl 295 14 the the DT cord-324859-0yuhb5dl 295 15 acute acute JJ cord-324859-0yuhb5dl 295 16 phase phase NN cord-324859-0yuhb5dl 295 17 of of IN cord-324859-0yuhb5dl 295 18 severe severe JJ cord-324859-0yuhb5dl 295 19 acute acute JJ cord-324859-0yuhb5dl 295 20 respiratory respiratory JJ cord-324859-0yuhb5dl 295 21 syndrome syndrome NN cord-324859-0yuhb5dl 296 1 Significant significant JJ cord-324859-0yuhb5dl 296 2 changes change NNS cord-324859-0yuhb5dl 296 3 of of IN cord-324859-0yuhb5dl 296 4 peripheral peripheral JJ cord-324859-0yuhb5dl 296 5 T t NN cord-324859-0yuhb5dl 296 6 lymphocyte lymphocyte NN cord-324859-0yuhb5dl 296 7 subsets subset NNS cord-324859-0yuhb5dl 296 8 in in IN cord-324859-0yuhb5dl 296 9 patients patient NNS cord-324859-0yuhb5dl 296 10 with with IN cord-324859-0yuhb5dl 296 11 severe severe JJ cord-324859-0yuhb5dl 296 12 acute acute JJ cord-324859-0yuhb5dl 296 13 respiratory respiratory JJ cord-324859-0yuhb5dl 296 14 syndrome syndrome NN cord-324859-0yuhb5dl 296 15 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 296 16 , , , cord-324859-0yuhb5dl 296 17 SARS SARS NNP cord-324859-0yuhb5dl 296 18 and and CC cord-324859-0yuhb5dl 296 19 MERS MERS NNP cord-324859-0yuhb5dl 296 20 : : : cord-324859-0yuhb5dl 296 21 are be VBP cord-324859-0yuhb5dl 296 22 they -PRON- PRP cord-324859-0yuhb5dl 296 23 closely closely RB cord-324859-0yuhb5dl 296 24 related relate VBN cord-324859-0yuhb5dl 296 25 ? ? . cord-324859-0yuhb5dl 297 1 Dynamic dynamic JJ cord-324859-0yuhb5dl 297 2 changes change NNS cord-324859-0yuhb5dl 297 3 of of IN cord-324859-0yuhb5dl 297 4 T t NN cord-324859-0yuhb5dl 297 5 lymphocyte lymphocyte NN cord-324859-0yuhb5dl 297 6 subsets subset NNS cord-324859-0yuhb5dl 297 7 in in IN cord-324859-0yuhb5dl 297 8 the the DT cord-324859-0yuhb5dl 297 9 long long JJ cord-324859-0yuhb5dl 297 10 - - HYPH cord-324859-0yuhb5dl 297 11 term term NN cord-324859-0yuhb5dl 297 12 follow follow NN cord-324859-0yuhb5dl 297 13 - - HYPH cord-324859-0yuhb5dl 297 14 up up NN cord-324859-0yuhb5dl 297 15 of of IN cord-324859-0yuhb5dl 297 16 severe severe JJ cord-324859-0yuhb5dl 297 17 acute acute JJ cord-324859-0yuhb5dl 297 18 respiratory respiratory JJ cord-324859-0yuhb5dl 297 19 syndrome syndrome NN cord-324859-0yuhb5dl 297 20 patients patient NNS cord-324859-0yuhb5dl 297 21 COVID-19 covid-19 VBP cord-324859-0yuhb5dl 297 22 : : : cord-324859-0yuhb5dl 297 23 consider consider VB cord-324859-0yuhb5dl 297 24 cytokine cytokine JJ cord-324859-0yuhb5dl 297 25 storm storm NN cord-324859-0yuhb5dl 297 26 syndromes syndrome NNS cord-324859-0yuhb5dl 297 27 and and CC cord-324859-0yuhb5dl 297 28 immunosuppression immunosuppression NN cord-324859-0yuhb5dl 297 29 IL-6 IL-6 NNP cord-324859-0yuhb5dl 297 30 in in IN cord-324859-0yuhb5dl 297 31 Inflammation inflammation NN cord-324859-0yuhb5dl 297 32 , , , cord-324859-0yuhb5dl 297 33 Immunity Immunity NNP cord-324859-0yuhb5dl 297 34 , , , cord-324859-0yuhb5dl 297 35 and and CC cord-324859-0yuhb5dl 297 36 Disease Disease NNP cord-324859-0yuhb5dl 298 1 The the DT cord-324859-0yuhb5dl 298 2 role role NN cord-324859-0yuhb5dl 298 3 of of IN cord-324859-0yuhb5dl 298 4 cytokines cytokine NNS cord-324859-0yuhb5dl 298 5 including include VBG cord-324859-0yuhb5dl 298 6 interleukin-6 interleukin-6 NNP cord-324859-0yuhb5dl 298 7 in in IN cord-324859-0yuhb5dl 298 8 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 298 9 induced induce VBN cord-324859-0yuhb5dl 298 10 pneumonia pneumonia NN cord-324859-0yuhb5dl 298 11 and and CC cord-324859-0yuhb5dl 298 12 macrophage macrophage NN cord-324859-0yuhb5dl 298 13 activation activation NN cord-324859-0yuhb5dl 298 14 syndrome syndrome NN cord-324859-0yuhb5dl 298 15 - - HYPH cord-324859-0yuhb5dl 298 16 like like JJ cord-324859-0yuhb5dl 298 17 disease disease NN cord-324859-0yuhb5dl 299 1 The the DT cord-324859-0yuhb5dl 299 2 role role NN cord-324859-0yuhb5dl 299 3 of of IN cord-324859-0yuhb5dl 299 4 interleukin interleukin NN cord-324859-0yuhb5dl 299 5 6 6 CD cord-324859-0yuhb5dl 299 6 during during IN cord-324859-0yuhb5dl 299 7 viral viral JJ cord-324859-0yuhb5dl 299 8 infections infection NNS cord-324859-0yuhb5dl 299 9 Effect Effect NNP cord-324859-0yuhb5dl 299 10 of of IN cord-324859-0yuhb5dl 299 11 remdesivir remdesivir NNP cord-324859-0yuhb5dl 299 12 vs vs IN cord-324859-0yuhb5dl 299 13 standard standard JJ cord-324859-0yuhb5dl 299 14 care care NN cord-324859-0yuhb5dl 299 15 on on IN cord-324859-0yuhb5dl 299 16 clinical clinical JJ cord-324859-0yuhb5dl 299 17 status status NN cord-324859-0yuhb5dl 299 18 at at IN cord-324859-0yuhb5dl 299 19 11 11 CD cord-324859-0yuhb5dl 299 20 days day NNS cord-324859-0yuhb5dl 299 21 in in IN cord-324859-0yuhb5dl 299 22 patients patient NNS cord-324859-0yuhb5dl 299 23 with with IN cord-324859-0yuhb5dl 299 24 moderate moderate JJ cord-324859-0yuhb5dl 299 25 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 299 26 : : : cord-324859-0yuhb5dl 299 27 a a DT cord-324859-0yuhb5dl 299 28 randomized randomized JJ cord-324859-0yuhb5dl 299 29 clinical clinical JJ cord-324859-0yuhb5dl 299 30 trial trial NN cord-324859-0yuhb5dl 299 31 Clinical clinical JJ cord-324859-0yuhb5dl 299 32 progression progression NN cord-324859-0yuhb5dl 299 33 and and CC cord-324859-0yuhb5dl 299 34 viral viral JJ cord-324859-0yuhb5dl 299 35 load load NN cord-324859-0yuhb5dl 299 36 in in IN cord-324859-0yuhb5dl 299 37 a a DT cord-324859-0yuhb5dl 299 38 community community NN cord-324859-0yuhb5dl 299 39 outbreak outbreak NN cord-324859-0yuhb5dl 299 40 of of IN cord-324859-0yuhb5dl 299 41 coronavirus coronavirus NN cord-324859-0yuhb5dl 299 42 - - HYPH cord-324859-0yuhb5dl 299 43 associated associate VBN cord-324859-0yuhb5dl 299 44 SARS SARS NNP cord-324859-0yuhb5dl 299 45 pneumonia pneumonia NN cord-324859-0yuhb5dl 299 46 : : : cord-324859-0yuhb5dl 299 47 a a DT cord-324859-0yuhb5dl 299 48 prospective prospective JJ cord-324859-0yuhb5dl 299 49 study study NN cord-324859-0yuhb5dl 299 50 Effect effect NN cord-324859-0yuhb5dl 299 51 of of IN cord-324859-0yuhb5dl 299 52 dexamethasone dexamethasone NN cord-324859-0yuhb5dl 299 53 in in IN cord-324859-0yuhb5dl 299 54 hospitalized hospitalize VBN cord-324859-0yuhb5dl 299 55 patients patient NNS cord-324859-0yuhb5dl 299 56 with with IN cord-324859-0yuhb5dl 299 57 COVID-19 COVID-19 NNP cord-324859-0yuhb5dl 299 58 : : : cord-324859-0yuhb5dl 299 59 preliminary preliminary JJ cord-324859-0yuhb5dl 299 60 report report NN cord-324859-0yuhb5dl 299 61 . . . cord-324859-0yuhb5dl 300 1 medRxiv medRxiv NNS cord-324859-0yuhb5dl 300 2 The the DT cord-324859-0yuhb5dl 300 3 authors author NNS cord-324859-0yuhb5dl 300 4 declare declare VBP cord-324859-0yuhb5dl 300 5 that that IN cord-324859-0yuhb5dl 300 6 they -PRON- PRP cord-324859-0yuhb5dl 300 7 have have VBP cord-324859-0yuhb5dl 300 8 no no DT cord-324859-0yuhb5dl 300 9 competing compete VBG cord-324859-0yuhb5dl 300 10 interests interest NNS cord-324859-0yuhb5dl 300 11 . . . cord-324859-0yuhb5dl 300 12 _SP