id sid tid token lemma pos cord-318457-k5kkd5qp 1 1 key key NN cord-318457-k5kkd5qp 1 2 : : : cord-318457-k5kkd5qp 1 3 cord-318457-k5kkd5qp cord-318457-k5kkd5qp NN cord-318457-k5kkd5qp 1 4 authors author NNS cord-318457-k5kkd5qp 1 5 : : : cord-318457-k5kkd5qp 1 6 Yoganathan Yoganathan NNP cord-318457-k5kkd5qp 1 7 , , , cord-318457-k5kkd5qp 1 8 Anusha Anusha NNP cord-318457-k5kkd5qp 1 9 ; ; : cord-318457-k5kkd5qp 1 10 Sajjad Sajjad NNP cord-318457-k5kkd5qp 1 11 , , , cord-318457-k5kkd5qp 1 12 Menahel Menahel NNP cord-318457-k5kkd5qp 1 13 S. S. NNP cord-318457-k5kkd5qp 1 14 ; ; : cord-318457-k5kkd5qp 1 15 Harky Harky NNP cord-318457-k5kkd5qp 1 16 , , , cord-318457-k5kkd5qp 1 17 Amer Amer NNP cord-318457-k5kkd5qp 1 18 title title NN cord-318457-k5kkd5qp 1 19 : : : cord-318457-k5kkd5qp 1 20 Cardiovascular cardiovascular JJ cord-318457-k5kkd5qp 1 21 disease disease NN cord-318457-k5kkd5qp 1 22 and and CC cord-318457-k5kkd5qp 1 23 the the DT cord-318457-k5kkd5qp 1 24 impact impact NN cord-318457-k5kkd5qp 1 25 of of IN cord-318457-k5kkd5qp 1 26 COVID‐19 COVID‐19 NNP cord-318457-k5kkd5qp 1 27 date date NN cord-318457-k5kkd5qp 1 28 : : : cord-318457-k5kkd5qp 1 29 2020 2020 CD cord-318457-k5kkd5qp 1 30 - - HYPH cord-318457-k5kkd5qp 1 31 06 06 CD cord-318457-k5kkd5qp 1 32 - - SYM cord-318457-k5kkd5qp 1 33 16 16 CD cord-318457-k5kkd5qp 1 34 journal journal NN cord-318457-k5kkd5qp 1 35 : : : cord-318457-k5kkd5qp 1 36 J J NNP cord-318457-k5kkd5qp 1 37 Card Card NNP cord-318457-k5kkd5qp 1 38 Surg Surg NNP cord-318457-k5kkd5qp 1 39 DOI doi NN cord-318457-k5kkd5qp 1 40 : : : cord-318457-k5kkd5qp 2 1 10.1111 10.1111 CD cord-318457-k5kkd5qp 2 2 / / SYM cord-318457-k5kkd5qp 2 3 jocs.14682 jocs.14682 NNP cord-318457-k5kkd5qp 2 4 sha sha NNP cord-318457-k5kkd5qp 2 5 : : : cord-318457-k5kkd5qp 3 1 6955c12361ab6c423d1362f4881a48f98163ca0a 6955c12361ab6c423d1362f4881a48f98163ca0a CD cord-318457-k5kkd5qp 3 2 doc_id doc_id CD cord-318457-k5kkd5qp 3 3 : : : cord-318457-k5kkd5qp 3 4 318457 318457 CD cord-318457-k5kkd5qp 3 5 cord_uid cord_uid NNS cord-318457-k5kkd5qp 3 6 : : : cord-318457-k5kkd5qp 4 1 k5kkd5qp k5kkd5qp NNP cord-318457-k5kkd5qp 4 2 nan nan NNP cord-318457-k5kkd5qp 5 1 It -PRON- PRP cord-318457-k5kkd5qp 5 2 is be VBZ cord-318457-k5kkd5qp 5 3 , , , cord-318457-k5kkd5qp 5 4 by by IN cord-318457-k5kkd5qp 5 5 now now RB cord-318457-k5kkd5qp 5 6 , , , cord-318457-k5kkd5qp 5 7 well well RB cord-318457-k5kkd5qp 5 8 established establish VBN cord-318457-k5kkd5qp 5 9 that that IN cord-318457-k5kkd5qp 5 10 patients patient NNS cord-318457-k5kkd5qp 5 11 with with IN cord-318457-k5kkd5qp 5 12 pre pre JJ cord-318457-k5kkd5qp 5 13 - - JJ cord-318457-k5kkd5qp 5 14 existing existing JJ cord-318457-k5kkd5qp 5 15 cardiovascular cardiovascular JJ cord-318457-k5kkd5qp 5 16 diseases disease NNS cord-318457-k5kkd5qp 5 17 , , , cord-318457-k5kkd5qp 5 18 such such JJ cord-318457-k5kkd5qp 5 19 as as IN cord-318457-k5kkd5qp 5 20 hypertension hypertension NN cord-318457-k5kkd5qp 5 21 or or CC cord-318457-k5kkd5qp 5 22 ischemic ischemic JJ cord-318457-k5kkd5qp 5 23 heart heart NN cord-318457-k5kkd5qp 5 24 disease disease NN cord-318457-k5kkd5qp 5 25 , , , cord-318457-k5kkd5qp 5 26 are be VBP cord-318457-k5kkd5qp 5 27 more more RBR cord-318457-k5kkd5qp 5 28 vulnerable vulnerable JJ cord-318457-k5kkd5qp 5 29 and and CC cord-318457-k5kkd5qp 5 30 at at IN cord-318457-k5kkd5qp 5 31 risk risk NN cord-318457-k5kkd5qp 5 32 from from IN cord-318457-k5kkd5qp 5 33 severe severe JJ cord-318457-k5kkd5qp 5 34 complications complication NNS cord-318457-k5kkd5qp 5 35 due due JJ cord-318457-k5kkd5qp 5 36 to to IN cord-318457-k5kkd5qp 5 37 COVID-19 COVID-19 NNP cord-318457-k5kkd5qp 5 38 . . . cord-318457-k5kkd5qp 6 1 One one CD cord-318457-k5kkd5qp 6 2 of of IN cord-318457-k5kkd5qp 6 3 the the DT cord-318457-k5kkd5qp 6 4 most most RBS cord-318457-k5kkd5qp 6 5 important important JJ cord-318457-k5kkd5qp 6 6 pathophysiology pathophysiology NN cord-318457-k5kkd5qp 6 7 of of IN cord-318457-k5kkd5qp 6 8 severe severe JJ cord-318457-k5kkd5qp 6 9 acute acute JJ cord-318457-k5kkd5qp 6 10 respiratory respiratory JJ cord-318457-k5kkd5qp 6 11 syndrome syndrome NN cord-318457-k5kkd5qp 6 12 coronavirus coronavirus NN cord-318457-k5kkd5qp 6 13 2 2 CD cord-318457-k5kkd5qp 7 1 ( ( -LRB- cord-318457-k5kkd5qp 7 2 SARS SARS NNP cord-318457-k5kkd5qp 7 3 - - HYPH cord-318457-k5kkd5qp 7 4 CoV-2 CoV-2 NNP cord-318457-k5kkd5qp 7 5 ) ) -RRB- cord-318457-k5kkd5qp 7 6 is be VBZ cord-318457-k5kkd5qp 7 7 lying lie VBG cord-318457-k5kkd5qp 7 8 in in IN cord-318457-k5kkd5qp 7 9 its -PRON- PRP$ cord-318457-k5kkd5qp 7 10 affinity affinity NN cord-318457-k5kkd5qp 7 11 to to IN cord-318457-k5kkd5qp 7 12 renin renin NN cord-318457-k5kkd5qp 7 13 - - HYPH cord-318457-k5kkd5qp 7 14 angiotensin angiotensin NN cord-318457-k5kkd5qp 7 15 - - HYPH cord-318457-k5kkd5qp 7 16 aldosterone aldosterone NN cord-318457-k5kkd5qp 7 17 system system NN cord-318457-k5kkd5qp 7 18 ( ( -LRB- cord-318457-k5kkd5qp 7 19 RAAS RAAS NNP cord-318457-k5kkd5qp 7 20 ) ) -RRB- cord-318457-k5kkd5qp 7 21 through through IN cord-318457-k5kkd5qp 7 22 angiotensin angiotensin NN cord-318457-k5kkd5qp 7 23 converting convert VBG cord-318457-k5kkd5qp 7 24 enzyme enzyme NN cord-318457-k5kkd5qp 7 25 inhibitor inhibitor NN cord-318457-k5kkd5qp 7 26 ( ( -LRB- cord-318457-k5kkd5qp 7 27 ACEi ACEi NNP cord-318457-k5kkd5qp 7 28 ) ) -RRB- cord-318457-k5kkd5qp 7 29 or or CC cord-318457-k5kkd5qp 7 30 utilization utilization NN cord-318457-k5kkd5qp 7 31 of of IN cord-318457-k5kkd5qp 7 32 angiotensin angiotensin NN cord-318457-k5kkd5qp 7 33 receptor receptor NN cord-318457-k5kkd5qp 7 34 blockers blocker NNS cord-318457-k5kkd5qp 7 35 ( ( -LRB- cord-318457-k5kkd5qp 7 36 ARBs arb NNS cord-318457-k5kkd5qp 7 37 ) ) -RRB- cord-318457-k5kkd5qp 7 38 . . . cord-318457-k5kkd5qp 8 1 Several several JJ cord-318457-k5kkd5qp 8 2 studies study NNS cord-318457-k5kkd5qp 8 3 have have VBP cord-318457-k5kkd5qp 8 4 reported report VBN cord-318457-k5kkd5qp 8 5 equivocal equivocal JJ cord-318457-k5kkd5qp 8 6 outcomes outcome NNS cord-318457-k5kkd5qp 8 7 in in IN cord-318457-k5kkd5qp 8 8 using use VBG cord-318457-k5kkd5qp 8 9 ACEi ACEi NNS cord-318457-k5kkd5qp 8 10 and and CC cord-318457-k5kkd5qp 8 11 ARBs arb NNS cord-318457-k5kkd5qp 8 12 in in IN cord-318457-k5kkd5qp 8 13 patients patient NNS cord-318457-k5kkd5qp 8 14 with with IN cord-318457-k5kkd5qp 8 15 COVID-19 COVID-19 NNP cord-318457-k5kkd5qp 8 16 , , , cord-318457-k5kkd5qp 8 17 whether whether IN cord-318457-k5kkd5qp 8 18 they -PRON- PRP cord-318457-k5kkd5qp 8 19 were be VBD cord-318457-k5kkd5qp 8 20 using use VBG cord-318457-k5kkd5qp 8 21 ACEi ACEi NNS cord-318457-k5kkd5qp 8 22 / / SYM cord-318457-k5kkd5qp 8 23 ARBs arb NNS cord-318457-k5kkd5qp 8 24 before before IN cord-318457-k5kkd5qp 8 25 contracting contract VBG cord-318457-k5kkd5qp 8 26 COVID-19 COVID-19 NNP cord-318457-k5kkd5qp 8 27 or or CC cord-318457-k5kkd5qp 8 28 they -PRON- PRP cord-318457-k5kkd5qp 8 29 were be VBD cord-318457-k5kkd5qp 8 30 initiated/ initiated/ . cord-318457-k5kkd5qp 9 1 suspended suspend VBN cord-318457-k5kkd5qp 9 2 during during IN cord-318457-k5kkd5qp 9 3 the the DT cord-318457-k5kkd5qp 9 4 course course NN cord-318457-k5kkd5qp 9 5 of of IN cord-318457-k5kkd5qp 9 6 the the DT cord-318457-k5kkd5qp 9 7 infection infection NN cord-318457-k5kkd5qp 9 8 ; ; : cord-318457-k5kkd5qp 9 9 yet yet CC cord-318457-k5kkd5qp 9 10 there there EX cord-318457-k5kkd5qp 9 11 is be VBZ cord-318457-k5kkd5qp 9 12 lack lack NN cord-318457-k5kkd5qp 9 13 of of IN cord-318457-k5kkd5qp 9 14 robust robust JJ cord-318457-k5kkd5qp 9 15 evidence evidence NN cord-318457-k5kkd5qp 9 16 supporting support VBG cord-318457-k5kkd5qp 9 17 the the DT cord-318457-k5kkd5qp 9 18 use use NN cord-318457-k5kkd5qp 9 19 or or CC cord-318457-k5kkd5qp 9 20 discontinuation discontinuation NN cord-318457-k5kkd5qp 9 21 of of IN cord-318457-k5kkd5qp 9 22 RAAS RAAS NNP cord-318457-k5kkd5qp 9 23 medications medication NNS cord-318457-k5kkd5qp 9 24 . . . cord-318457-k5kkd5qp 10 1 2 2 LS cord-318457-k5kkd5qp 10 2 , , , cord-318457-k5kkd5qp 10 3 3 3 CD cord-318457-k5kkd5qp 11 1 Although although IN cord-318457-k5kkd5qp 11 2 , , , cord-318457-k5kkd5qp 11 3 there there EX cord-318457-k5kkd5qp 11 4 is be VBZ cord-318457-k5kkd5qp 11 5 a a DT cord-318457-k5kkd5qp 11 6 theory theory NN cord-318457-k5kkd5qp 11 7 that that IN cord-318457-k5kkd5qp 11 8 ACEi acei NN cord-318457-k5kkd5qp 11 9 / / SYM cord-318457-k5kkd5qp 11 10 ARBs arb NNS cord-318457-k5kkd5qp 11 11 antagonise antagonise VBP cord-318457-k5kkd5qp 11 12 RAAS RAAS NNP cord-318457-k5kkd5qp 11 13 which which WDT cord-318457-k5kkd5qp 11 14 might may MD cord-318457-k5kkd5qp 11 15 reduce reduce VB cord-318457-k5kkd5qp 11 16 inflammation inflammation NN cord-318457-k5kkd5qp 11 17 in in IN cord-318457-k5kkd5qp 11 18 COVID-19 COVID-19 NNP cord-318457-k5kkd5qp 11 19 pneumonia pneumonia NN cord-318457-k5kkd5qp 11 20 , , , cord-318457-k5kkd5qp 11 21 thus thus RB cord-318457-k5kkd5qp 11 22 reducing reduce VBG cord-318457-k5kkd5qp 11 23 mortality mortality NN cord-318457-k5kkd5qp 11 24 . . . cord-318457-k5kkd5qp 12 1 2 2 CD cord-318457-k5kkd5qp 12 2 , , , cord-318457-k5kkd5qp 12 3 4 4 CD cord-318457-k5kkd5qp 13 1 The the DT cord-318457-k5kkd5qp 13 2 study study NN cord-318457-k5kkd5qp 13 3 by by IN cord-318457-k5kkd5qp 13 4 Zhang Zhang NNP cord-318457-k5kkd5qp 13 5 et et NNP cord-318457-k5kkd5qp 13 6 al al NNP cord-318457-k5kkd5qp 13 7 4 4 CD cord-318457-k5kkd5qp 13 8 _SP cord-318457-k5kkd5qp 14 1 At at IN cord-318457-k5kkd5qp 14 2 the the DT cord-318457-k5kkd5qp 14 3 heart heart NN cord-318457-k5kkd5qp 14 4 of of IN cord-318457-k5kkd5qp 14 5 COVID-19 COVID-19 NNP cord-318457-k5kkd5qp 14 6 Reninangiotensin Reninangiotensin NNP cord-318457-k5kkd5qp 14 7 - - HYPH cord-318457-k5kkd5qp 14 8 aldosterone aldosterone NN cord-318457-k5kkd5qp 14 9 system system NN cord-318457-k5kkd5qp 14 10 blockers blocker NNS cord-318457-k5kkd5qp 14 11 and and CC cord-318457-k5kkd5qp 14 12 the the DT cord-318457-k5kkd5qp 14 13 risk risk NN cord-318457-k5kkd5qp 14 14 of of IN cord-318457-k5kkd5qp 14 15 Covid-19 Covid-19 NNP cord-318457-k5kkd5qp 14 16 Continuing Continuing NNP cord-318457-k5kkd5qp 14 17 versus versus IN cord-318457-k5kkd5qp 14 18 suspending suspend VBG cord-318457-k5kkd5qp 14 19 angiotensin angiotensin NN cord-318457-k5kkd5qp 14 20 - - HYPH cord-318457-k5kkd5qp 14 21 converting convert VBG cord-318457-k5kkd5qp 14 22 enzyme enzyme NN cord-318457-k5kkd5qp 14 23 inhibitors inhibitor NNS cord-318457-k5kkd5qp 14 24 and and CC cord-318457-k5kkd5qp 14 25 angiotensin angiotensin NN cord-318457-k5kkd5qp 14 26 receptor receptor NN cord-318457-k5kkd5qp 14 27 blockers blocker NNS cord-318457-k5kkd5qp 14 28 : : : cord-318457-k5kkd5qp 14 29 impact impact NN cord-318457-k5kkd5qp 14 30 on on IN cord-318457-k5kkd5qp 14 31 adverse adverse JJ cord-318457-k5kkd5qp 14 32 outcomes outcome NNS cord-318457-k5kkd5qp 14 33 in in IN cord-318457-k5kkd5qp 14 34 hospitalized hospitalize VBN cord-318457-k5kkd5qp 14 35 patients patient NNS cord-318457-k5kkd5qp 14 36 with with IN cord-318457-k5kkd5qp 14 37 severe severe JJ cord-318457-k5kkd5qp 14 38 acute acute JJ cord-318457-k5kkd5qp 14 39 respiratory respiratory JJ cord-318457-k5kkd5qp 14 40 syndrome syndrome NN cord-318457-k5kkd5qp 14 41 coronavirus coronavirus NN cord-318457-k5kkd5qp 14 42 2 2 CD cord-318457-k5kkd5qp 15 1 ( ( -LRB- cord-318457-k5kkd5qp 15 2 SARS SARS NNP cord-318457-k5kkd5qp 15 3 - - HYPH cord-318457-k5kkd5qp 15 4 CoV-2 CoV-2 NNP cord-318457-k5kkd5qp 15 5 ) ) -RRB- cord-318457-k5kkd5qp 15 6 Association Association NNP cord-318457-k5kkd5qp 15 7 of of IN cord-318457-k5kkd5qp 15 8 inpatient inpatient JJ cord-318457-k5kkd5qp 15 9 use use NN cord-318457-k5kkd5qp 15 10 of of IN cord-318457-k5kkd5qp 15 11 angiotensin angiotensin NN cord-318457-k5kkd5qp 15 12 converting convert VBG cord-318457-k5kkd5qp 15 13 enzyme enzyme NN cord-318457-k5kkd5qp 15 14 inhibitors inhibitor NNS cord-318457-k5kkd5qp 15 15 and and CC cord-318457-k5kkd5qp 15 16 angiotensin angiotensin NN cord-318457-k5kkd5qp 15 17 II ii CD cord-318457-k5kkd5qp 15 18 receptor receptor NN cord-318457-k5kkd5qp 15 19 blockers blocker NNS cord-318457-k5kkd5qp 15 20 with with IN cord-318457-k5kkd5qp 15 21 mortality mortality NN cord-318457-k5kkd5qp 15 22 among among IN cord-318457-k5kkd5qp 15 23 patients patient NNS cord-318457-k5kkd5qp 15 24 with with IN cord-318457-k5kkd5qp 15 25 hypertension hypertension NN cord-318457-k5kkd5qp 15 26 hospitalized hospitalize VBN cord-318457-k5kkd5qp 15 27 with with IN cord-318457-k5kkd5qp 15 28 COVID-19 COVID-19 NNP