id sid tid token lemma pos cord-317820-od9l7p1r 1 1 key key JJ cord-317820-od9l7p1r 1 2 : : : cord-317820-od9l7p1r 1 3 cord-317820-od9l7p1r cord-317820-od9l7p1r NNP cord-317820-od9l7p1r 1 4 authors author NNS cord-317820-od9l7p1r 1 5 : : : cord-317820-od9l7p1r 1 6 Goker Goker NNP cord-317820-od9l7p1r 1 7 Bagca Bagca NNP cord-317820-od9l7p1r 1 8 , , , cord-317820-od9l7p1r 1 9 Bakiye Bakiye NNP cord-317820-od9l7p1r 1 10 ; ; : cord-317820-od9l7p1r 2 1 Biray Biray NNP cord-317820-od9l7p1r 2 2 Avci Avci NNP cord-317820-od9l7p1r 2 3 , , , cord-317820-od9l7p1r 2 4 Cigir Cigir NNP cord-317820-od9l7p1r 2 5 title title NN cord-317820-od9l7p1r 2 6 : : : cord-317820-od9l7p1r 2 7 Overview Overview NNP cord-317820-od9l7p1r 2 8 of of IN cord-317820-od9l7p1r 2 9 the the DT cord-317820-od9l7p1r 2 10 COVID-19 COVID-19 NNP cord-317820-od9l7p1r 2 11 and and CC cord-317820-od9l7p1r 2 12 JAK JAK NNP cord-317820-od9l7p1r 2 13 / / SYM cord-317820-od9l7p1r 2 14 STAT STAT NNP cord-317820-od9l7p1r 2 15 Pathway Pathway NNP cord-317820-od9l7p1r 2 16 Inhibition Inhibition NNP cord-317820-od9l7p1r 2 17 : : : cord-317820-od9l7p1r 3 1 Ruxolitinib Ruxolitinib NNP cord-317820-od9l7p1r 3 2 Perspective Perspective NNP cord-317820-od9l7p1r 3 3 date date NN cord-317820-od9l7p1r 3 4 : : : cord-317820-od9l7p1r 3 5 2020 2020 CD cord-317820-od9l7p1r 3 6 - - HYPH cord-317820-od9l7p1r 3 7 06 06 CD cord-317820-od9l7p1r 3 8 - - SYM cord-317820-od9l7p1r 3 9 20 20 CD cord-317820-od9l7p1r 3 10 journal journal NN cord-317820-od9l7p1r 3 11 : : : cord-317820-od9l7p1r 3 12 Cytokine Cytokine NNP cord-317820-od9l7p1r 3 13 Growth Growth NNP cord-317820-od9l7p1r 3 14 Factor Factor NNP cord-317820-od9l7p1r 3 15 Rev Rev NNP cord-317820-od9l7p1r 3 16 DOI DOI NNP cord-317820-od9l7p1r 3 17 : : : cord-317820-od9l7p1r 3 18 10.1016 10.1016 CD cord-317820-od9l7p1r 4 1 /j.cytogfr.2020.06.013 /j.cytogfr.2020.06.013 NNP cord-317820-od9l7p1r 4 2 sha sha NNP cord-317820-od9l7p1r 4 3 : : : cord-317820-od9l7p1r 5 1 3365ff721887db064235b8e123b824ee0dd7a13e 3365ff721887db064235b8e123b824ee0dd7a13e IN cord-317820-od9l7p1r 5 2 doc_id doc_id CD cord-317820-od9l7p1r 5 3 : : : cord-317820-od9l7p1r 6 1 317820 317820 CD cord-317820-od9l7p1r 6 2 cord_uid cord_uid NN cord-317820-od9l7p1r 6 3 : : : cord-317820-od9l7p1r 7 1 od9l7p1r od9l7p1r NNP cord-317820-od9l7p1r 7 2 Ruxolitinib Ruxolitinib NNP cord-317820-od9l7p1r 7 3 is be VBZ cord-317820-od9l7p1r 7 4 the the DT cord-317820-od9l7p1r 7 5 first first JJ cord-317820-od9l7p1r 7 6 approved approve VBN cord-317820-od9l7p1r 7 7 JAK1 JAK1 NNP cord-317820-od9l7p1r 7 8 and and CC cord-317820-od9l7p1r 7 9 JAK2 JAK2 NNP cord-317820-od9l7p1r 7 10 inhibitor inhibitor NN cord-317820-od9l7p1r 7 11 . . . cord-317820-od9l7p1r 8 1 It -PRON- PRP cord-317820-od9l7p1r 8 2 inhibits inhibit VBZ cord-317820-od9l7p1r 8 3 the the DT cord-317820-od9l7p1r 8 4 JAK JAK NNP cord-317820-od9l7p1r 8 5 / / SYM cord-317820-od9l7p1r 8 6 STAT stat NN cord-317820-od9l7p1r 8 7 pathway pathway NN cord-317820-od9l7p1r 8 8 which which WDT cord-317820-od9l7p1r 8 9 is be VBZ cord-317820-od9l7p1r 8 10 one one CD cord-317820-od9l7p1r 8 11 of of IN cord-317820-od9l7p1r 8 12 the the DT cord-317820-od9l7p1r 8 13 main main JJ cord-317820-od9l7p1r 8 14 cellular cellular JJ cord-317820-od9l7p1r 8 15 signaling signal VBG cord-317820-od9l7p1r 8 16 pathways pathway NNS cord-317820-od9l7p1r 8 17 especially especially RB cord-317820-od9l7p1r 8 18 regulates regulate VBZ cord-317820-od9l7p1r 8 19 inflammatory inflammatory JJ cord-317820-od9l7p1r 8 20 response response NN cord-317820-od9l7p1r 8 21 . . . cord-317820-od9l7p1r 9 1 COVID-19 COVID-19 NNP cord-317820-od9l7p1r 9 2 is be VBZ cord-317820-od9l7p1r 9 3 an an DT cord-317820-od9l7p1r 9 4 urgent urgent JJ cord-317820-od9l7p1r 9 5 pandemic pandemic NN cord-317820-od9l7p1r 9 6 situation situation NN cord-317820-od9l7p1r 9 7 caused cause VBN cord-317820-od9l7p1r 9 8 by by IN cord-317820-od9l7p1r 9 9 SARS SARS NNP cord-317820-od9l7p1r 9 10 - - HYPH cord-317820-od9l7p1r 9 11 CoV-2 CoV-2 NNP cord-317820-od9l7p1r 9 12 infection infection NN cord-317820-od9l7p1r 9 13 . . . cord-317820-od9l7p1r 10 1 This this DT cord-317820-od9l7p1r 10 2 review review NN cord-317820-od9l7p1r 10 3 firstly firstly RB cord-317820-od9l7p1r 10 4 presents present VBZ cord-317820-od9l7p1r 10 5 an an DT cord-317820-od9l7p1r 10 6 overview overview NN cord-317820-od9l7p1r 10 7 of of IN cord-317820-od9l7p1r 10 8 SARS SARS NNP cord-317820-od9l7p1r 10 9 - - HYPH cord-317820-od9l7p1r 10 10 CoV-2 CoV-2 NNP cord-317820-od9l7p1r 10 11 and and CC cord-317820-od9l7p1r 10 12 COVID-19 COVID-19 NNP cord-317820-od9l7p1r 10 13 , , , cord-317820-od9l7p1r 10 14 and and CC cord-317820-od9l7p1r 10 15 then then RB cord-317820-od9l7p1r 10 16 it -PRON- PRP cord-317820-od9l7p1r 10 17 focuses focus VBZ cord-317820-od9l7p1r 10 18 on on IN cord-317820-od9l7p1r 10 19 the the DT cord-317820-od9l7p1r 10 20 potential potential JJ cord-317820-od9l7p1r 10 21 efficacy efficacy NN cord-317820-od9l7p1r 10 22 of of IN cord-317820-od9l7p1r 10 23 ruxolitinib ruxolitinib NN cord-317820-od9l7p1r 10 24 in in IN cord-317820-od9l7p1r 10 25 this this DT cord-317820-od9l7p1r 10 26 infection infection NN cord-317820-od9l7p1r 10 27 . . . cord-317820-od9l7p1r 11 1 The the DT cord-317820-od9l7p1r 11 2 possible possible JJ cord-317820-od9l7p1r 11 3 targets target NNS cord-317820-od9l7p1r 11 4 of of IN cord-317820-od9l7p1r 11 5 ruxolitinib ruxolitinib NNP cord-317820-od9l7p1r 11 6 are be VBP cord-317820-od9l7p1r 11 7 determined determine VBN cord-317820-od9l7p1r 11 8 by by IN cord-317820-od9l7p1r 11 9 using use VBG cord-317820-od9l7p1r 11 10 genetic genetic JJ cord-317820-od9l7p1r 11 11 alterations alteration NNS cord-317820-od9l7p1r 11 12 that that WDT cord-317820-od9l7p1r 11 13 have have VBP cord-317820-od9l7p1r 11 14 been be VBN cord-317820-od9l7p1r 11 15 reported report VBN cord-317820-od9l7p1r 11 16 in in IN cord-317820-od9l7p1r 11 17 COVID-19 COVID-19 NNP cord-317820-od9l7p1r 11 18 patients patient NNS cord-317820-od9l7p1r 11 19 . . . cord-317820-od9l7p1r 12 1 The the DT cord-317820-od9l7p1r 12 2 potential potential JJ cord-317820-od9l7p1r 12 3 effectiveness effectiveness NN cord-317820-od9l7p1r 12 4 of of IN cord-317820-od9l7p1r 12 5 ruxolitinib ruxolitinib NNP cord-317820-od9l7p1r 12 6 is be VBZ cord-317820-od9l7p1r 12 7 suggested suggest VBN cord-317820-od9l7p1r 12 8 by by IN cord-317820-od9l7p1r 12 9 evaluating evaluate VBG cord-317820-od9l7p1r 12 10 the the DT cord-317820-od9l7p1r 12 11 interactions interaction NNS cord-317820-od9l7p1r 12 12 of of IN cord-317820-od9l7p1r 12 13 these these DT cord-317820-od9l7p1r 12 14 potential potential JJ cord-317820-od9l7p1r 12 15 targets target NNS cord-317820-od9l7p1r 12 16 which which WDT cord-317820-od9l7p1r 12 17 are be VBP cord-317820-od9l7p1r 12 18 directly directly RB cord-317820-od9l7p1r 12 19 affected affect VBN cord-317820-od9l7p1r 12 20 by by IN cord-317820-od9l7p1r 12 21 the the DT cord-317820-od9l7p1r 12 22 ruxolitinib ruxolitinib NN cord-317820-od9l7p1r 12 23 or or CC cord-317820-od9l7p1r 12 24 JAK JAK NNP cord-317820-od9l7p1r 12 25 / / SYM cord-317820-od9l7p1r 12 26 STAT stat NN cord-317820-od9l7p1r 12 27 pathway pathway NN cord-317820-od9l7p1r 12 28 . . . cord-317820-od9l7p1r 13 1 The the DT cord-317820-od9l7p1r 13 2 virus virus NN cord-317820-od9l7p1r 13 3 , , , cord-317820-od9l7p1r 13 4 which which WDT cord-317820-od9l7p1r 13 5 is be VBZ cord-317820-od9l7p1r 13 6 the the DT cord-317820-od9l7p1r 13 7 cause cause NN cord-317820-od9l7p1r 13 8 of of IN cord-317820-od9l7p1r 13 9 the the DT cord-317820-od9l7p1r 13 10 COVID-19 covid-19 NN cord-317820-od9l7p1r 13 11 was be VBD cord-317820-od9l7p1r 13 12 named name VBN cord-317820-od9l7p1r 13 13 as as IN cord-317820-od9l7p1r 13 14 Severe severe JJ cord-317820-od9l7p1r 13 15 Acute acute JJ cord-317820-od9l7p1r 13 16 Respiratory respiratory JJ cord-317820-od9l7p1r 13 17 Syndromerelated Syndromerelated NNP cord-317820-od9l7p1r 13 18 Coronavirus Coronavirus NNP cord-317820-od9l7p1r 13 19 ( ( -LRB- cord-317820-od9l7p1r 13 20 SARS SARS NNP cord-317820-od9l7p1r 13 21 - - HYPH cord-317820-od9l7p1r 13 22 CoV-2 CoV-2 NNP cord-317820-od9l7p1r 13 23 ) ) -RRB- cord-317820-od9l7p1r 13 24 by by IN cord-317820-od9l7p1r 13 25 Coronaviridae Coronaviridae NNP cord-317820-od9l7p1r 13 26 Study Study NNP cord-317820-od9l7p1r 13 27 Group Group NNP cord-317820-od9l7p1r 13 28 of of IN cord-317820-od9l7p1r 13 29 the the DT cord-317820-od9l7p1r 13 30 International International NNP cord-317820-od9l7p1r 13 31 Committee Committee NNP cord-317820-od9l7p1r 13 32 on on IN cord-317820-od9l7p1r 13 33 Taxonomy Taxonomy NNP cord-317820-od9l7p1r 13 34 of of IN cord-317820-od9l7p1r 13 35 Viruses Viruses NNPS cord-317820-od9l7p1r 13 36 ( ( -LRB- cord-317820-od9l7p1r 13 37 Figure figure NN cord-317820-od9l7p1r 13 38 1a 1a CD cord-317820-od9l7p1r 13 39 ) ) -RRB- cord-317820-od9l7p1r 13 40 . . . cord-317820-od9l7p1r 14 1 SARS SARS NNP cord-317820-od9l7p1r 14 2 - - HYPH cord-317820-od9l7p1r 14 3 CoV-2 CoV-2 NNP cord-317820-od9l7p1r 14 4 is be VBZ cord-317820-od9l7p1r 14 5 a a DT cord-317820-od9l7p1r 14 6 betacoronavirus betacoronavirus NN cord-317820-od9l7p1r 14 7 and and CC cord-317820-od9l7p1r 14 8 it -PRON- PRP cord-317820-od9l7p1r 14 9 is be VBZ cord-317820-od9l7p1r 14 10 in in IN cord-317820-od9l7p1r 14 11 the the DT cord-317820-od9l7p1r 14 12 Coronaviridae Coronaviridae NNP cord-317820-od9l7p1r 14 13 family family NN cord-317820-od9l7p1r 14 14 along along IN cord-317820-od9l7p1r 14 15 with with IN cord-317820-od9l7p1r 14 16 two two CD cord-317820-od9l7p1r 14 17 other other JJ cord-317820-od9l7p1r 14 18 species specie NNS cord-317820-od9l7p1r 14 19 that that WDT cord-317820-od9l7p1r 14 20 infect infect VBP cord-317820-od9l7p1r 14 21 humans human NNS cord-317820-od9l7p1r 14 22 , , , cord-317820-od9l7p1r 14 23 SARS SARS NNP cord-317820-od9l7p1r 14 24 - - HYPH cord-317820-od9l7p1r 14 25 CoV CoV NNP cord-317820-od9l7p1r 14 26 , , , cord-317820-od9l7p1r 14 27 and and CC cord-317820-od9l7p1r 14 28 MERS MERS NNP cord-317820-od9l7p1r 14 29 - - HYPH cord-317820-od9l7p1r 14 30 CoV CoV NNP cord-317820-od9l7p1r 14 31 [ [ -LRB- cord-317820-od9l7p1r 14 32 3 3 CD cord-317820-od9l7p1r 14 33 ] ] -RRB- cord-317820-od9l7p1r 14 34 . . . cord-317820-od9l7p1r 15 1 The the DT cord-317820-od9l7p1r 15 2 genomic genomic JJ cord-317820-od9l7p1r 15 3 structure structure NN cord-317820-od9l7p1r 15 4 of of IN cord-317820-od9l7p1r 15 5 the the DT cord-317820-od9l7p1r 15 6 virus virus NN cord-317820-od9l7p1r 15 7 is be VBZ cord-317820-od9l7p1r 15 8 a a DT cord-317820-od9l7p1r 15 9 positive positive JJ cord-317820-od9l7p1r 15 10 - - HYPH cord-317820-od9l7p1r 15 11 sense sense NN cord-317820-od9l7p1r 15 12 , , , cord-317820-od9l7p1r 15 13 single single RB cord-317820-od9l7p1r 15 14 - - HYPH cord-317820-od9l7p1r 15 15 stranded strand VBN cord-317820-od9l7p1r 15 16 RNA rna NN cord-317820-od9l7p1r 15 17 which which WDT cord-317820-od9l7p1r 15 18 is be VBZ cord-317820-od9l7p1r 15 19 approximately approximately RB cord-317820-od9l7p1r 15 20 30 30 CD cord-317820-od9l7p1r 15 21 kb kb NNP cord-317820-od9l7p1r 15 22 ( ( -LRB- cord-317820-od9l7p1r 15 23 29903 29903 CD cord-317820-od9l7p1r 15 24 nucleotides nucleotide NNS cord-317820-od9l7p1r 15 25 ) ) -RRB- cord-317820-od9l7p1r 15 26 . . . cord-317820-od9l7p1r 16 1 The the DT cord-317820-od9l7p1r 16 2 viral viral JJ cord-317820-od9l7p1r 16 3 RNA RNA NNP cord-317820-od9l7p1r 16 4 is be VBZ cord-317820-od9l7p1r 16 5 packaged package VBN cord-317820-od9l7p1r 16 6 by by IN cord-317820-od9l7p1r 16 7 nucleocapsid nucleocapsid NN cord-317820-od9l7p1r 16 8 proteins protein NNS cord-317820-od9l7p1r 16 9 and and CC cord-317820-od9l7p1r 16 10 this this DT cord-317820-od9l7p1r 16 11 structure structure NN cord-317820-od9l7p1r 16 12 is be VBZ cord-317820-od9l7p1r 16 13 surrounded surround VBN cord-317820-od9l7p1r 16 14 by by IN cord-317820-od9l7p1r 16 15 a a DT cord-317820-od9l7p1r 16 16 bilayer bilayer JJ cord-317820-od9l7p1r 16 17 lipid lipid NN cord-317820-od9l7p1r 16 18 corona corona NN cord-317820-od9l7p1r 16 19 structure structure NN cord-317820-od9l7p1r 16 20 which which WDT cord-317820-od9l7p1r 16 21 includes include VBZ cord-317820-od9l7p1r 16 22 membrane membrane NN cord-317820-od9l7p1r 16 23 , , , cord-317820-od9l7p1r 16 24 envelope envelope NN cord-317820-od9l7p1r 16 25 , , , cord-317820-od9l7p1r 16 26 and and CC cord-317820-od9l7p1r 16 27 spike spike NN cord-317820-od9l7p1r 16 28 proteins protein NNS cord-317820-od9l7p1r 16 29 ( ( -LRB- cord-317820-od9l7p1r 16 30 Figure figure NN cord-317820-od9l7p1r 16 31 1b 1b CD cord-317820-od9l7p1r 16 32 ) ) -RRB- cord-317820-od9l7p1r 17 1 The the DT cord-317820-od9l7p1r 17 2 S S NNP cord-317820-od9l7p1r 17 3 protein protein NN cord-317820-od9l7p1r 17 4 of of IN cord-317820-od9l7p1r 17 5 virion virion NN cord-317820-od9l7p1r 17 6 binds bind VBZ cord-317820-od9l7p1r 17 7 to to IN cord-317820-od9l7p1r 17 8 the the DT cord-317820-od9l7p1r 17 9 ACE2 ACE2 NNP cord-317820-od9l7p1r 17 10 receptor receptor NN cord-317820-od9l7p1r 17 11 of of IN cord-317820-od9l7p1r 17 12 the the DT cord-317820-od9l7p1r 17 13 cell cell NN cord-317820-od9l7p1r 17 14 that that WDT cord-317820-od9l7p1r 17 15 will will MD cord-317820-od9l7p1r 17 16 be be VB cord-317820-od9l7p1r 17 17 infected infect VBN cord-317820-od9l7p1r 17 18 by by IN cord-317820-od9l7p1r 17 19 the the DT cord-317820-od9l7p1r 17 20 virus virus NN cord-317820-od9l7p1r 17 21 ( ( -LRB- cord-317820-od9l7p1r 17 22 Figure figure NN cord-317820-od9l7p1r 17 23 1c 1c CD cord-317820-od9l7p1r 17 24 ) ) -RRB- cord-317820-od9l7p1r 17 25 . . . cord-317820-od9l7p1r 18 1 In in IN cord-317820-od9l7p1r 18 2 the the DT cord-317820-od9l7p1r 18 3 process process NN cord-317820-od9l7p1r 18 4 following follow VBG cord-317820-od9l7p1r 18 5 the the DT cord-317820-od9l7p1r 18 6 binding binding NN cord-317820-od9l7p1r 18 7 , , , cord-317820-od9l7p1r 18 8 it -PRON- PRP cord-317820-od9l7p1r 18 9 is be VBZ cord-317820-od9l7p1r 18 10 suggested suggest VBN cord-317820-od9l7p1r 18 11 that that IN cord-317820-od9l7p1r 18 12 proteases protease NNS cord-317820-od9l7p1r 18 13 especially especially RB cord-317820-od9l7p1r 18 14 TMPRSS2 TMPRSS2 NNP cord-317820-od9l7p1r 18 15 , , , cord-317820-od9l7p1r 18 16 on on IN cord-317820-od9l7p1r 18 17 the the DT cord-317820-od9l7p1r 18 18 surface surface NN cord-317820-od9l7p1r 18 19 of of IN cord-317820-od9l7p1r 18 20 the the DT cord-317820-od9l7p1r 18 21 host host NN cord-317820-od9l7p1r 18 22 cell cell NN cord-317820-od9l7p1r 18 23 can can MD cord-317820-od9l7p1r 18 24 strengthen strengthen VB cord-317820-od9l7p1r 18 25 binding binding NN cord-317820-od9l7p1r 18 26 and and CC cord-317820-od9l7p1r 18 27 trigger trigger VB cord-317820-od9l7p1r 18 28 receptor receptor NN cord-317820-od9l7p1r 18 29 - - HYPH cord-317820-od9l7p1r 18 30 mediated mediate VBN cord-317820-od9l7p1r 18 31 endocytosis endocytosis NN cord-317820-od9l7p1r 18 32 by by IN cord-317820-od9l7p1r 18 33 causing cause VBG cord-317820-od9l7p1r 18 34 conformational conformational JJ cord-317820-od9l7p1r 18 35 changes change NNS cord-317820-od9l7p1r 18 36 in in IN cord-317820-od9l7p1r 18 37 the the DT cord-317820-od9l7p1r 18 38 S S NNP cord-317820-od9l7p1r 18 39 glycoprotein glycoprotein NN cord-317820-od9l7p1r 18 40 [ [ -LRB- cord-317820-od9l7p1r 18 41 5 5 CD cord-317820-od9l7p1r 18 42 ] ] -RRB- cord-317820-od9l7p1r 18 43 . . . cord-317820-od9l7p1r 19 1 The the DT cord-317820-od9l7p1r 19 2 early early JJ cord-317820-od9l7p1r 19 3 endosome endosome NN cord-317820-od9l7p1r 19 4 carrying carry VBG cord-317820-od9l7p1r 19 5 the the DT cord-317820-od9l7p1r 19 6 virion virion NN cord-317820-od9l7p1r 19 7 matures mature VBZ cord-317820-od9l7p1r 19 8 towards towards IN cord-317820-od9l7p1r 19 9 the the DT cord-317820-od9l7p1r 19 10 late late JJ cord-317820-od9l7p1r 19 11 endosome endosome NN cord-317820-od9l7p1r 19 12 during during IN cord-317820-od9l7p1r 19 13 vesicular vesicular JJ cord-317820-od9l7p1r 19 14 traffic traffic NN cord-317820-od9l7p1r 19 15 process process NN cord-317820-od9l7p1r 19 16 and and CC cord-317820-od9l7p1r 19 17 the the DT cord-317820-od9l7p1r 19 18 gradual gradual JJ cord-317820-od9l7p1r 19 19 increase increase NN cord-317820-od9l7p1r 19 20 in in IN cord-317820-od9l7p1r 19 21 the the DT cord-317820-od9l7p1r 19 22 endosomal endosomal NNP cord-317820-od9l7p1r 20 1 lumen lumen JJ cord-317820-od9l7p1r 20 2 acidity acidity NN cord-317820-od9l7p1r 20 3 causes cause VBZ cord-317820-od9l7p1r 20 4 the the DT cord-317820-od9l7p1r 20 5 release release NN cord-317820-od9l7p1r 20 6 of of IN cord-317820-od9l7p1r 20 7 the the DT cord-317820-od9l7p1r 20 8 viral viral JJ cord-317820-od9l7p1r 20 9 genome genome NN cord-317820-od9l7p1r 20 10 to to IN cord-317820-od9l7p1r 20 11 the the DT cord-317820-od9l7p1r 20 12 cytoplasm cytoplasm NN cord-317820-od9l7p1r 20 13 [ [ -LRB- cord-317820-od9l7p1r 20 14 7 7 CD cord-317820-od9l7p1r 20 15 ] ] -RRB- cord-317820-od9l7p1r 20 16 . . . cord-317820-od9l7p1r 21 1 Firstly firstly RB cord-317820-od9l7p1r 21 2 , , , cord-317820-od9l7p1r 21 3 ORF1ab ORF1ab NNP cord-317820-od9l7p1r 21 4 is be VBZ cord-317820-od9l7p1r 21 5 translated translate VBN cord-317820-od9l7p1r 21 6 using use VBG cord-317820-od9l7p1r 21 7 the the DT cord-317820-od9l7p1r 21 8 viral viral JJ cord-317820-od9l7p1r 21 9 RNA RNA NNP cord-317820-od9l7p1r 21 10 , , , cord-317820-od9l7p1r 21 11 and and CC cord-317820-od9l7p1r 21 12 its -PRON- PRP$ cord-317820-od9l7p1r 21 13 cleavage cleavage NN cord-317820-od9l7p1r 21 14 forms form NNS cord-317820-od9l7p1r 21 15 RNA rna NN cord-317820-od9l7p1r 21 16 - - HYPH cord-317820-od9l7p1r 21 17 dependent dependent JJ cord-317820-od9l7p1r 21 18 RNA RNA NNP cord-317820-od9l7p1r 21 19 polymerase polymerase NN cord-317820-od9l7p1r 21 20 which which WDT cord-317820-od9l7p1r 21 21 involved involve VBN cord-317820-od9l7p1r 21 22 in in IN cord-317820-od9l7p1r 21 23 both both DT cord-317820-od9l7p1r 21 24 replication replication NN cord-317820-od9l7p1r 21 25 and and CC cord-317820-od9l7p1r 21 26 transcription transcription NN cord-317820-od9l7p1r 21 27 of of IN cord-317820-od9l7p1r 21 28 structural structural JJ cord-317820-od9l7p1r 21 29 proteins protein NNS cord-317820-od9l7p1r 21 30 . . . cord-317820-od9l7p1r 22 1 Using use VBG cord-317820-od9l7p1r 22 2 these these DT cord-317820-od9l7p1r 22 3 transcripts transcript NNS cord-317820-od9l7p1r 22 4 , , , cord-317820-od9l7p1r 22 5 cytoplasmic cytoplasmic JJ cord-317820-od9l7p1r 22 6 ribosomes ribosome NNS cord-317820-od9l7p1r 22 7 translate translate VBP cord-317820-od9l7p1r 22 8 the the DT cord-317820-od9l7p1r 22 9 nucleocapsid nucleocapsid NNP cord-317820-od9l7p1r 22 10 protein protein NN cord-317820-od9l7p1r 22 11 , , , cord-317820-od9l7p1r 22 12 and and CC cord-317820-od9l7p1r 22 13 ER er NN cord-317820-od9l7p1r 22 14 - - HYPH cord-317820-od9l7p1r 22 15 bound bind VBN cord-317820-od9l7p1r 22 16 ribosomes ribosome NNS cord-317820-od9l7p1r 22 17 translate translate VBP cord-317820-od9l7p1r 22 18 the the DT cord-317820-od9l7p1r 22 19 spike spike NN cord-317820-od9l7p1r 22 20 , , , cord-317820-od9l7p1r 22 21 envelope envelope NN cord-317820-od9l7p1r 22 22 , , , cord-317820-od9l7p1r 22 23 and and CC cord-317820-od9l7p1r 22 24 membrane membrane NN cord-317820-od9l7p1r 22 25 proteins protein NNS cord-317820-od9l7p1r 22 26 into into IN cord-317820-od9l7p1r 22 27 the the DT cord-317820-od9l7p1r 22 28 ER ER NNP cord-317820-od9l7p1r 22 29 lumen lumen NN cord-317820-od9l7p1r 22 30 . . . cord-317820-od9l7p1r 23 1 Nucleocapsid nucleocapsid NN cord-317820-od9l7p1r 23 2 packed pack VBD cord-317820-od9l7p1r 23 3 viral viral JJ cord-317820-od9l7p1r 23 4 RNA RNA NNP cord-317820-od9l7p1r 23 5 is be VBZ cord-317820-od9l7p1r 23 6 encapsulated encapsulate VBN cord-317820-od9l7p1r 23 7 the the DT cord-317820-od9l7p1r 23 8 vesicle vesicle NN cord-317820-od9l7p1r 23 9 which which WDT cord-317820-od9l7p1r 23 10 carries carry VBZ cord-317820-od9l7p1r 23 11 spike spike NN cord-317820-od9l7p1r 23 12 , , , cord-317820-od9l7p1r 23 13 envelope envelope NN cord-317820-od9l7p1r 23 14 , , , cord-317820-od9l7p1r 23 15 and and CC cord-317820-od9l7p1r 23 16 membrane membrane NN cord-317820-od9l7p1r 23 17 proteins protein NNS cord-317820-od9l7p1r 23 18 on on IN cord-317820-od9l7p1r 23 19 its -PRON- PRP$ cord-317820-od9l7p1r 23 20 membrane membrane NN cord-317820-od9l7p1r 23 21 in in IN cord-317820-od9l7p1r 23 22 Endoplasmic Endoplasmic NNP cord-317820-od9l7p1r 23 23 Reticulum Reticulum NNP cord-317820-od9l7p1r 23 24 Golgi Golgi NNP cord-317820-od9l7p1r 23 25 Intermediate Intermediate NNP cord-317820-od9l7p1r 23 26 Compartment Compartment NNP cord-317820-od9l7p1r 23 27 ( ( -LRB- cord-317820-od9l7p1r 23 28 ERGIC ERGIC NNP cord-317820-od9l7p1r 23 29 ) ) -RRB- cord-317820-od9l7p1r 23 30 . . . cord-317820-od9l7p1r 24 1 Finally finally RB cord-317820-od9l7p1r 24 2 , , , cord-317820-od9l7p1r 24 3 a a DT cord-317820-od9l7p1r 24 4 complete complete JJ cord-317820-od9l7p1r 24 5 virion virion NN cord-317820-od9l7p1r 24 6 is be VBZ cord-317820-od9l7p1r 24 7 released release VBN cord-317820-od9l7p1r 24 8 to to IN cord-317820-od9l7p1r 24 9 the the DT cord-317820-od9l7p1r 24 10 extracellular extracellular JJ cord-317820-od9l7p1r 24 11 region region NN cord-317820-od9l7p1r 24 12 by by IN cord-317820-od9l7p1r 24 13 exocytosis exocytosis NN cord-317820-od9l7p1r 24 14 [ [ -LRB- cord-317820-od9l7p1r 24 15 8 8 CD cord-317820-od9l7p1r 24 16 ] ] -RRB- cord-317820-od9l7p1r 24 17 . . . cord-317820-od9l7p1r 25 1 Symptoms Symptoms NNP cord-317820-od9l7p1r 25 2 J J NNP cord-317820-od9l7p1r 25 3 o o NN cord-317820-od9l7p1r 25 4 u u NN cord-317820-od9l7p1r 25 5 r r NN cord-317820-od9l7p1r 25 6 n n NN cord-317820-od9l7p1r 25 7 a a DT cord-317820-od9l7p1r 25 8 l l NN cord-317820-od9l7p1r 25 9 P p NN cord-317820-od9l7p1r 25 10 r r NN cord-317820-od9l7p1r 25 11 e e NN cord-317820-od9l7p1r 25 12 -p -p NN cord-317820-od9l7p1r 25 13 r r NN cord-317820-od9l7p1r 25 14 o o NN cord-317820-od9l7p1r 26 1 o o UH cord-317820-od9l7p1r 26 2 f f NNP cord-317820-od9l7p1r 26 3 SARS SARS NNP cord-317820-od9l7p1r 26 4 - - HYPH cord-317820-od9l7p1r 26 5 CoV-2 CoV-2 NNP cord-317820-od9l7p1r 26 6 is be VBZ cord-317820-od9l7p1r 26 7 transmitted transmit VBN cord-317820-od9l7p1r 26 8 from from IN cord-317820-od9l7p1r 26 9 human human JJ cord-317820-od9l7p1r 26 10 to to IN cord-317820-od9l7p1r 26 11 human human NN cord-317820-od9l7p1r 26 12 with with IN cord-317820-od9l7p1r 26 13 droplets droplet NNS cord-317820-od9l7p1r 26 14 and and CC cord-317820-od9l7p1r 26 15 from from IN cord-317820-od9l7p1r 26 16 the the DT cord-317820-od9l7p1r 26 17 mucosal mucosal JJ cord-317820-od9l7p1r 26 18 surfaces surface NNS cord-317820-od9l7p1r 26 19 of of IN cord-317820-od9l7p1r 26 20 the the DT cord-317820-od9l7p1r 26 21 nose nose NN cord-317820-od9l7p1r 26 22 , , , cord-317820-od9l7p1r 26 23 mouth mouth NN cord-317820-od9l7p1r 26 24 , , , cord-317820-od9l7p1r 26 25 and and CC cord-317820-od9l7p1r 26 26 eyes eye NNS cord-317820-od9l7p1r 26 27 [ [ -LRB- cord-317820-od9l7p1r 26 28 9 9 CD cord-317820-od9l7p1r 26 29 ] ] -RRB- cord-317820-od9l7p1r 26 30 . . . cord-317820-od9l7p1r 27 1 It -PRON- PRP cord-317820-od9l7p1r 27 2 is be VBZ cord-317820-od9l7p1r 27 3 thought think VBN cord-317820-od9l7p1r 27 4 that that IN cord-317820-od9l7p1r 27 5 the the DT cord-317820-od9l7p1r 27 6 majority majority NN cord-317820-od9l7p1r 27 7 of of IN cord-317820-od9l7p1r 27 8 the the DT cord-317820-od9l7p1r 27 9 SARS SARS NNP cord-317820-od9l7p1r 27 10 - - HYPH cord-317820-od9l7p1r 27 11 CoV-2 CoV-2 NNP cord-317820-od9l7p1r 27 12 infected infect VBN cord-317820-od9l7p1r 27 13 individuals individual NNS cord-317820-od9l7p1r 27 14 are be VBP cord-317820-od9l7p1r 27 15 asymptomatic asymptomatic JJ cord-317820-od9l7p1r 27 16 depending depend VBG cord-317820-od9l7p1r 27 17 on on IN cord-317820-od9l7p1r 27 18 their -PRON- PRP$ cord-317820-od9l7p1r 27 19 general general JJ cord-317820-od9l7p1r 27 20 health health NN cord-317820-od9l7p1r 27 21 conditions condition NNS cord-317820-od9l7p1r 27 22 and and CC cord-317820-od9l7p1r 27 23 ages age NNS cord-317820-od9l7p1r 27 24 . . . cord-317820-od9l7p1r 28 1 Fever fever NN cord-317820-od9l7p1r 28 2 , , , cord-317820-od9l7p1r 28 3 dry dry JJ cord-317820-od9l7p1r 28 4 cough cough NN cord-317820-od9l7p1r 28 5 , , , cord-317820-od9l7p1r 28 6 fatigue fatigue NN cord-317820-od9l7p1r 28 7 or or CC cord-317820-od9l7p1r 28 8 weakness weakness NN cord-317820-od9l7p1r 28 9 , , , cord-317820-od9l7p1r 28 10 and and CC cord-317820-od9l7p1r 28 11 dyspnea dyspnea NN cord-317820-od9l7p1r 28 12 are be VBP cord-317820-od9l7p1r 28 13 the the DT cord-317820-od9l7p1r 28 14 most most RBS cord-317820-od9l7p1r 28 15 common common JJ cord-317820-od9l7p1r 28 16 ( ( -LRB- cord-317820-od9l7p1r 28 17 > > NFP cord-317820-od9l7p1r 28 18 50 50 CD cord-317820-od9l7p1r 28 19 % % NN cord-317820-od9l7p1r 28 20 ) ) -RRB- cord-317820-od9l7p1r 28 21 ; ; : cord-317820-od9l7p1r 28 22 myalgia myalgia NNP cord-317820-od9l7p1r 28 23 , , , cord-317820-od9l7p1r 28 24 chest chest NN cord-317820-od9l7p1r 28 25 oppression oppression NN cord-317820-od9l7p1r 28 26 or or CC cord-317820-od9l7p1r 28 27 pain pain NN cord-317820-od9l7p1r 28 28 , , , cord-317820-od9l7p1r 28 29 diarrhea diarrhea NN cord-317820-od9l7p1r 28 30 , , , cord-317820-od9l7p1r 28 31 loss loss NN cord-317820-od9l7p1r 28 32 of of IN cord-317820-od9l7p1r 28 33 or or CC cord-317820-od9l7p1r 28 34 poor poor JJ cord-317820-od9l7p1r 28 35 appetite appetite NN cord-317820-od9l7p1r 28 36 , , , cord-317820-od9l7p1r 28 37 shortness shortness NN cord-317820-od9l7p1r 28 38 of of IN cord-317820-od9l7p1r 28 39 breath breath NN cord-317820-od9l7p1r 28 40 , , , cord-317820-od9l7p1r 28 41 expectoration expectoration NN cord-317820-od9l7p1r 28 42 , , , cord-317820-od9l7p1r 28 43 anorexia anorexia NN cord-317820-od9l7p1r 28 44 are be VBP cord-317820-od9l7p1r 28 45 common common JJ cord-317820-od9l7p1r 28 46 ( ( -LRB- cord-317820-od9l7p1r 28 47 < < XX cord-317820-od9l7p1r 28 48 50 50 CD cord-317820-od9l7p1r 28 49 % % NN cord-317820-od9l7p1r 28 50 and and CC cord-317820-od9l7p1r 28 51 > > XX cord-317820-od9l7p1r 28 52 10 10 CD cord-317820-od9l7p1r 28 53 % % NN cord-317820-od9l7p1r 28 54 ) ) -RRB- cord-317820-od9l7p1r 28 55 ; ; : cord-317820-od9l7p1r 28 56 headache headache NN cord-317820-od9l7p1r 28 57 , , , cord-317820-od9l7p1r 28 58 chest chest NN cord-317820-od9l7p1r 28 59 pain pain NN cord-317820-od9l7p1r 28 60 , , , cord-317820-od9l7p1r 28 61 sore sore JJ cord-317820-od9l7p1r 28 62 throat throat NN cord-317820-od9l7p1r 28 63 , , , cord-317820-od9l7p1r 28 64 vomiting vomiting NN cord-317820-od9l7p1r 28 65 , , , cord-317820-od9l7p1r 28 66 loss loss NN cord-317820-od9l7p1r 28 67 of of IN cord-317820-od9l7p1r 28 68 smell smell NN cord-317820-od9l7p1r 28 69 and and CC cord-317820-od9l7p1r 28 70 taste taste NN cord-317820-od9l7p1r 28 71 are be VBP cord-317820-od9l7p1r 28 72 the the DT cord-317820-od9l7p1r 28 73 less less RBR cord-317820-od9l7p1r 28 74 common common JJ cord-317820-od9l7p1r 28 75 ( ( -LRB- cord-317820-od9l7p1r 28 76 < < NNP cord-317820-od9l7p1r 28 77 10 10 CD cord-317820-od9l7p1r 28 78 % % NN cord-317820-od9l7p1r 28 79 ) ) -RRB- cord-317820-od9l7p1r 28 80 symptoms symptom NNS cord-317820-od9l7p1r 28 81 of of IN cord-317820-od9l7p1r 28 82 the the DT cord-317820-od9l7p1r 28 83 diagnosed diagnose VBN cord-317820-od9l7p1r 28 84 cases case NNS cord-317820-od9l7p1r 28 85 [ [ -LRB- cord-317820-od9l7p1r 28 86 10 10 CD cord-317820-od9l7p1r 28 87 ] ] -RRB- cord-317820-od9l7p1r 28 88 [ [ -LRB- cord-317820-od9l7p1r 28 89 11 11 CD cord-317820-od9l7p1r 28 90 ] ] -RRB- cord-317820-od9l7p1r 28 91 [ [ -LRB- cord-317820-od9l7p1r 28 92 12 12 CD cord-317820-od9l7p1r 28 93 ] ] -RRB- cord-317820-od9l7p1r 28 94 [ [ -LRB- cord-317820-od9l7p1r 28 95 13 13 CD cord-317820-od9l7p1r 28 96 ] ] -RRB- cord-317820-od9l7p1r 28 97 [ [ -LRB- cord-317820-od9l7p1r 28 98 14 14 CD cord-317820-od9l7p1r 28 99 ] ] -RRB- cord-317820-od9l7p1r 28 100 [ [ -LRB- cord-317820-od9l7p1r 28 101 15 15 CD cord-317820-od9l7p1r 28 102 ] ] -RRB- cord-317820-od9l7p1r 28 103 [ [ -LRB- cord-317820-od9l7p1r 28 104 16 16 CD cord-317820-od9l7p1r 28 105 ] ] -RRB- cord-317820-od9l7p1r 28 106 [ [ -LRB- cord-317820-od9l7p1r 28 107 17 17 CD cord-317820-od9l7p1r 28 108 ] ] -RRB- cord-317820-od9l7p1r 28 109 [ [ -LRB- cord-317820-od9l7p1r 28 110 18 18 CD cord-317820-od9l7p1r 28 111 ] ] -RRB- cord-317820-od9l7p1r 28 112 [ [ -LRB- cord-317820-od9l7p1r 28 113 19 19 CD cord-317820-od9l7p1r 28 114 ] ] -RRB- cord-317820-od9l7p1r 28 115 [ [ -LRB- cord-317820-od9l7p1r 28 116 20 20 CD cord-317820-od9l7p1r 28 117 ] ] -RRB- cord-317820-od9l7p1r 28 118 . . . cord-317820-od9l7p1r 29 1 In in IN cord-317820-od9l7p1r 29 2 addition addition NN cord-317820-od9l7p1r 29 3 to to IN cord-317820-od9l7p1r 29 4 general general JJ cord-317820-od9l7p1r 29 5 symptoms symptom NNS cord-317820-od9l7p1r 29 6 and and CC cord-317820-od9l7p1r 29 7 laboratory laboratory NN cord-317820-od9l7p1r 29 8 findings finding NNS cord-317820-od9l7p1r 29 9 , , , cord-317820-od9l7p1r 29 10 chest chest NN cord-317820-od9l7p1r 29 11 computed compute VBN cord-317820-od9l7p1r 29 12 tomography tomography NN cord-317820-od9l7p1r 29 13 ( ( -LRB- cord-317820-od9l7p1r 29 14 CT CT NNP cord-317820-od9l7p1r 29 15 ) ) -RRB- cord-317820-od9l7p1r 29 16 , , , cord-317820-od9l7p1r 29 17 rapid rapid JJ cord-317820-od9l7p1r 29 18 antibody antibody NN cord-317820-od9l7p1r 29 19 - - HYPH cord-317820-od9l7p1r 29 20 based base VBN cord-317820-od9l7p1r 29 21 methods method NNS cord-317820-od9l7p1r 29 22 , , , cord-317820-od9l7p1r 29 23 and and CC cord-317820-od9l7p1r 29 24 molecular molecular JJ cord-317820-od9l7p1r 29 25 tests test NNS cord-317820-od9l7p1r 29 26 including include VBG cord-317820-od9l7p1r 29 27 Real Real NNP cord-317820-od9l7p1r 29 28 - - HYPH cord-317820-od9l7p1r 29 29 Time time NN cord-317820-od9l7p1r 29 30 Reverse Reverse NNP cord-317820-od9l7p1r 29 31 Transcriptase Transcriptase NNP cord-317820-od9l7p1r 29 32 - - HYPH cord-317820-od9l7p1r 29 33 PCR PCR NNP cord-317820-od9l7p1r 29 34 are be VBP cord-317820-od9l7p1r 29 35 utilized utilize VBN cord-317820-od9l7p1r 29 36 for for IN cord-317820-od9l7p1r 29 37 diagnosis diagnosis NN cord-317820-od9l7p1r 29 38 of of IN cord-317820-od9l7p1r 29 39 COVID-19 COVID-19 NNP cord-317820-od9l7p1r 29 40 [ [ -LRB- cord-317820-od9l7p1r 29 41 10 10 CD cord-317820-od9l7p1r 29 42 ] ] -RRB- cord-317820-od9l7p1r 29 43 . . . cord-317820-od9l7p1r 30 1 SARS SARS NNP cord-317820-od9l7p1r 30 2 - - HYPH cord-317820-od9l7p1r 30 3 CoV-2 CoV-2 NNP cord-317820-od9l7p1r 30 4 was be VBD cord-317820-od9l7p1r 30 5 isolated isolate VBN cord-317820-od9l7p1r 30 6 from from IN cord-317820-od9l7p1r 30 7 different different JJ cord-317820-od9l7p1r 30 8 clinical clinical JJ cord-317820-od9l7p1r 30 9 samples sample NNS cord-317820-od9l7p1r 30 10 including include VBG cord-317820-od9l7p1r 30 11 upper upper JJ cord-317820-od9l7p1r 30 12 and and CC cord-317820-od9l7p1r 30 13 lower low JJR cord-317820-od9l7p1r 30 14 respiratory respiratory JJ cord-317820-od9l7p1r 30 15 tract tract NN cord-317820-od9l7p1r 30 16 passages passage NNS cord-317820-od9l7p1r 30 17 , , , cord-317820-od9l7p1r 30 18 blood blood NN cord-317820-od9l7p1r 30 19 , , , cord-317820-od9l7p1r 30 20 and and CC cord-317820-od9l7p1r 30 21 stool stool NN cord-317820-od9l7p1r 30 22 . . . cord-317820-od9l7p1r 31 1 However however RB cord-317820-od9l7p1r 31 2 infectious infectious JJ cord-317820-od9l7p1r 31 3 property property NN cord-317820-od9l7p1r 31 4 of of IN cord-317820-od9l7p1r 31 5 the the DT cord-317820-od9l7p1r 31 6 live live JJ cord-317820-od9l7p1r 31 7 virus virus NN cord-317820-od9l7p1r 31 8 is be VBZ cord-317820-od9l7p1r 31 9 not not RB cord-317820-od9l7p1r 31 10 exactly exactly RB cord-317820-od9l7p1r 31 11 defined define VBN cord-317820-od9l7p1r 31 12 , , , cord-317820-od9l7p1r 31 13 exclude exclude VBP cord-317820-od9l7p1r 31 14 obtained obtain VBN cord-317820-od9l7p1r 31 15 from from IN cord-317820-od9l7p1r 31 16 the the DT cord-317820-od9l7p1r 31 17 respiratory respiratory JJ cord-317820-od9l7p1r 31 18 tract tract NN cord-317820-od9l7p1r 31 19 samples sample NNS cord-317820-od9l7p1r 31 20 [ [ -LRB- cord-317820-od9l7p1r 31 21 21 21 CD cord-317820-od9l7p1r 31 22 ] ] -RRB- cord-317820-od9l7p1r 31 23 . . . cord-317820-od9l7p1r 32 1 According accord VBG cord-317820-od9l7p1r 32 2 to to IN cord-317820-od9l7p1r 32 3 Real real JJ cord-317820-od9l7p1r 32 4 - - HYPH cord-317820-od9l7p1r 32 5 Time time NN cord-317820-od9l7p1r 32 6 Reverse Reverse NNP cord-317820-od9l7p1r 32 7 Transcriptase Transcriptase NNP cord-317820-od9l7p1r 32 8 - - HYPH cord-317820-od9l7p1r 32 9 PCR pcr NN cord-317820-od9l7p1r 32 10 test test NN cord-317820-od9l7p1r 32 11 results result NNS cord-317820-od9l7p1r 32 12 , , , cord-317820-od9l7p1r 32 13 the the DT cord-317820-od9l7p1r 32 14 positivity positivity NN cord-317820-od9l7p1r 32 15 rate rate NN cord-317820-od9l7p1r 32 16 decreases decrease NNS cord-317820-od9l7p1r 32 17 in in IN cord-317820-od9l7p1r 32 18 the the DT cord-317820-od9l7p1r 32 19 form form NN cord-317820-od9l7p1r 32 20 of of IN cord-317820-od9l7p1r 32 21 bronchoalveolar bronchoalveolar NNP cord-317820-od9l7p1r 32 22 lavage lavage NN cord-317820-od9l7p1r 32 23 , , , cord-317820-od9l7p1r 32 24 sputum sputum NN cord-317820-od9l7p1r 32 25 , , , cord-317820-od9l7p1r 32 26 throat throat NN cord-317820-od9l7p1r 32 27 , , , cord-317820-od9l7p1r 32 28 nasal nasal NN cord-317820-od9l7p1r 32 29 and and CC cord-317820-od9l7p1r 32 30 pharyngeal pharyngeal JJ cord-317820-od9l7p1r 32 31 swabs swab NNS cord-317820-od9l7p1r 32 32 , , , cord-317820-od9l7p1r 32 33 respectively respectively RB cord-317820-od9l7p1r 32 34 [ [ -LRB- cord-317820-od9l7p1r 32 35 22 22 CD cord-317820-od9l7p1r 32 36 ] ] -RRB- cord-317820-od9l7p1r 32 37 . . . cord-317820-od9l7p1r 33 1 Similarly similarly RB cord-317820-od9l7p1r 33 2 , , , cord-317820-od9l7p1r 33 3 the the DT cord-317820-od9l7p1r 33 4 rate rate NN cord-317820-od9l7p1r 33 5 is be VBZ cord-317820-od9l7p1r 33 6 higher high JJR cord-317820-od9l7p1r 33 7 in in IN cord-317820-od9l7p1r 33 8 the the DT cord-317820-od9l7p1r 33 9 early early JJ cord-317820-od9l7p1r 33 10 and and CC cord-317820-od9l7p1r 33 11 progressive progressive JJ cord-317820-od9l7p1r 33 12 stages stage NNS cord-317820-od9l7p1r 33 13 of of IN cord-317820-od9l7p1r 33 14 the the DT cord-317820-od9l7p1r 33 15 disease disease NN cord-317820-od9l7p1r 33 16 than than IN cord-317820-od9l7p1r 33 17 the the DT cord-317820-od9l7p1r 33 18 recovery recovery NN cord-317820-od9l7p1r 33 19 stage stage NN cord-317820-od9l7p1r 33 20 . . . cord-317820-od9l7p1r 34 1 The the DT cord-317820-od9l7p1r 34 2 high high JJ cord-317820-od9l7p1r 34 3 viral viral JJ cord-317820-od9l7p1r 34 4 load load NN cord-317820-od9l7p1r 34 5 and and CC cord-317820-od9l7p1r 34 6 infectious infectious JJ cord-317820-od9l7p1r 34 7 property property NN cord-317820-od9l7p1r 34 8 of of IN cord-317820-od9l7p1r 34 9 the the DT cord-317820-od9l7p1r 34 10 respiratory respiratory JJ cord-317820-od9l7p1r 34 11 samples sample NNS cord-317820-od9l7p1r 34 12 are be VBP cord-317820-od9l7p1r 34 13 suggested suggest VBN cord-317820-od9l7p1r 34 14 as as IN cord-317820-od9l7p1r 34 15 proof proof NN cord-317820-od9l7p1r 34 16 of of IN cord-317820-od9l7p1r 34 17 respiratory respiratory JJ cord-317820-od9l7p1r 34 18 transmission transmission NN cord-317820-od9l7p1r 34 19 [ [ -LRB- cord-317820-od9l7p1r 34 20 23 23 CD cord-317820-od9l7p1r 34 21 ] ] -RRB- cord-317820-od9l7p1r 34 22 . . . cord-317820-od9l7p1r 35 1 Elderly elderly JJ cord-317820-od9l7p1r 35 2 age age NN cord-317820-od9l7p1r 35 3 ( ( -LRB- cord-317820-od9l7p1r 35 4 ≥ ≥ CD cord-317820-od9l7p1r 35 5 65 65 CD cord-317820-od9l7p1r 35 6 years year NNS cord-317820-od9l7p1r 35 7 ) ) -RRB- cord-317820-od9l7p1r 35 8 is be VBZ cord-317820-od9l7p1r 35 9 defined define VBN cord-317820-od9l7p1r 35 10 as as IN cord-317820-od9l7p1r 35 11 the the DT cord-317820-od9l7p1r 35 12 most most RBS cord-317820-od9l7p1r 35 13 common common JJ cord-317820-od9l7p1r 35 14 risk risk NN cord-317820-od9l7p1r 35 15 factor factor NN cord-317820-od9l7p1r 35 16 . . . cord-317820-od9l7p1r 36 1 Comorbidities comorbiditie NNS cord-317820-od9l7p1r 36 2 that that WDT cord-317820-od9l7p1r 36 3 are be VBP cord-317820-od9l7p1r 36 4 hypertension hypertension NN cord-317820-od9l7p1r 36 5 , , , cord-317820-od9l7p1r 36 6 cardiovascular cardiovascular JJ cord-317820-od9l7p1r 36 7 diseases disease NNS cord-317820-od9l7p1r 36 8 , , , cord-317820-od9l7p1r 36 9 diabetes diabetes NN cord-317820-od9l7p1r 36 10 , , , cord-317820-od9l7p1r 36 11 chronic chronic JJ cord-317820-od9l7p1r 36 12 obstructive obstructive JJ cord-317820-od9l7p1r 36 13 pulmonary pulmonary JJ cord-317820-od9l7p1r 36 14 diseases disease NNS cord-317820-od9l7p1r 36 15 , , , cord-317820-od9l7p1r 36 16 malignancies malignancy NNS cord-317820-od9l7p1r 36 17 , , , cord-317820-od9l7p1r 36 18 chronic chronic JJ cord-317820-od9l7p1r 36 19 kidney kidney NN cord-317820-od9l7p1r 36 20 or or CC cord-317820-od9l7p1r 36 21 hepatic hepatic JJ cord-317820-od9l7p1r 36 22 diseases disease NNS cord-317820-od9l7p1r 36 23 , , , cord-317820-od9l7p1r 36 24 asthma asthma NN cord-317820-od9l7p1r 36 25 , , , cord-317820-od9l7p1r 36 26 or or CC cord-317820-od9l7p1r 36 27 infectious infectious JJ cord-317820-od9l7p1r 36 28 diseases disease NNS cord-317820-od9l7p1r 36 29 like like IN cord-317820-od9l7p1r 36 30 as as IN cord-317820-od9l7p1r 36 31 tuberculosis tuberculosis NN cord-317820-od9l7p1r 36 32 , , , cord-317820-od9l7p1r 36 33 and and CC cord-317820-od9l7p1r 36 34 hepatitis hepatitis NN cord-317820-od9l7p1r 36 35 are be VBP cord-317820-od9l7p1r 36 36 identified identify VBN cord-317820-od9l7p1r 36 37 as as IN cord-317820-od9l7p1r 36 38 the the DT cord-317820-od9l7p1r 36 39 other other JJ cord-317820-od9l7p1r 36 40 following follow VBG cord-317820-od9l7p1r 36 41 risk risk NN cord-317820-od9l7p1r 36 42 groups group NNS cord-317820-od9l7p1r 36 43 [ [ -LRB- cord-317820-od9l7p1r 36 44 10 10 CD cord-317820-od9l7p1r 36 45 , , , cord-317820-od9l7p1r 36 46 11 11 CD cord-317820-od9l7p1r 36 47 , , , cord-317820-od9l7p1r 36 48 13 13 CD cord-317820-od9l7p1r 36 49 , , , cord-317820-od9l7p1r 36 50 17 17 CD cord-317820-od9l7p1r 36 51 , , , cord-317820-od9l7p1r 36 52 19 19 CD cord-317820-od9l7p1r 36 53 , , , cord-317820-od9l7p1r 36 54 24 24 CD cord-317820-od9l7p1r 36 55 ] ] -RRB- cord-317820-od9l7p1r 36 56 . . . cord-317820-od9l7p1r 37 1 Although although IN cord-317820-od9l7p1r 37 2 smoking smoking NN cord-317820-od9l7p1r 37 3 is be VBZ cord-317820-od9l7p1r 37 4 the the DT cord-317820-od9l7p1r 37 5 main main JJ cord-317820-od9l7p1r 37 6 risk risk NN cord-317820-od9l7p1r 37 7 factor factor NN cord-317820-od9l7p1r 37 8 of of IN cord-317820-od9l7p1r 37 9 various various JJ cord-317820-od9l7p1r 37 10 diseases disease NNS cord-317820-od9l7p1r 37 11 especially especially RB cord-317820-od9l7p1r 37 12 lung lung NN cord-317820-od9l7p1r 37 13 cancers cancer NNS cord-317820-od9l7p1r 37 14 , , , cord-317820-od9l7p1r 37 15 it -PRON- PRP cord-317820-od9l7p1r 37 16 is be VBZ cord-317820-od9l7p1r 37 17 not not RB cord-317820-od9l7p1r 37 18 certainly certainly RB cord-317820-od9l7p1r 37 19 classified classify VBN cord-317820-od9l7p1r 37 20 as as IN cord-317820-od9l7p1r 37 21 the the DT cord-317820-od9l7p1r 37 22 risk risk NN cord-317820-od9l7p1r 37 23 factor factor NN cord-317820-od9l7p1r 37 24 of of IN cord-317820-od9l7p1r 37 25 COVID-19 COVID-19 NNP cord-317820-od9l7p1r 37 26 , , , cord-317820-od9l7p1r 37 27 yet yet CC cord-317820-od9l7p1r 37 28 [ [ -LRB- cord-317820-od9l7p1r 37 29 25 25 CD cord-317820-od9l7p1r 37 30 ] ] -RRB- cord-317820-od9l7p1r 37 31 . . . cord-317820-od9l7p1r 38 1 It -PRON- PRP cord-317820-od9l7p1r 38 2 has have VBZ cord-317820-od9l7p1r 38 3 also also RB cord-317820-od9l7p1r 38 4 been be VBN cord-317820-od9l7p1r 38 5 noted note VBN cord-317820-od9l7p1r 38 6 that that IN cord-317820-od9l7p1r 38 7 various various JJ cord-317820-od9l7p1r 38 8 genetic genetic JJ cord-317820-od9l7p1r 38 9 factors factor NNS cord-317820-od9l7p1r 38 10 may may MD cord-317820-od9l7p1r 38 11 affect affect VB cord-317820-od9l7p1r 38 12 the the DT cord-317820-od9l7p1r 38 13 prognosis prognosis NN cord-317820-od9l7p1r 38 14 of of IN cord-317820-od9l7p1r 38 15 COVID-19 COVID-19 NNP cord-317820-od9l7p1r 38 16 . . . cord-317820-od9l7p1r 39 1 For for IN cord-317820-od9l7p1r 39 2 example example NN cord-317820-od9l7p1r 39 3 , , , cord-317820-od9l7p1r 39 4 it -PRON- PRP cord-317820-od9l7p1r 39 5 has have VBZ cord-317820-od9l7p1r 39 6 been be VBN cord-317820-od9l7p1r 39 7 stated state VBN cord-317820-od9l7p1r 39 8 that that IN cord-317820-od9l7p1r 39 9 the the DT cord-317820-od9l7p1r 39 10 phenotypes phenotype NNS cord-317820-od9l7p1r 39 11 of of IN cord-317820-od9l7p1r 39 12 HLA HLA NNP cord-317820-od9l7p1r 39 13 - - HYPH cord-317820-od9l7p1r 39 14 B B NNP cord-317820-od9l7p1r 39 15 * * NFP cord-317820-od9l7p1r 39 16 46:01 46:01 CD cord-317820-od9l7p1r 39 17 and and CC cord-317820-od9l7p1r 39 18 HLA HLA NNP cord-317820-od9l7p1r 39 19 - - HYPH cord-317820-od9l7p1r 39 20 B*15:03 B*15:03 NNP cord-317820-od9l7p1r 39 21 can can MD cord-317820-od9l7p1r 39 22 affect affect VB cord-317820-od9l7p1r 39 23 the the DT cord-317820-od9l7p1r 39 24 severity severity NN cord-317820-od9l7p1r 39 25 of of IN cord-317820-od9l7p1r 39 26 infection infection NN cord-317820-od9l7p1r 39 27 by by IN cord-317820-od9l7p1r 39 28 causing cause VBG cord-317820-od9l7p1r 39 29 low low JJ cord-317820-od9l7p1r 39 30 and and CC cord-317820-od9l7p1r 39 31 high high JJ cord-317820-od9l7p1r 39 32 binding bind VBG cord-317820-od9l7p1r 39 33 affinity affinity NN cord-317820-od9l7p1r 39 34 of of IN cord-317820-od9l7p1r 39 35 SARS SARS NNP cord-317820-od9l7p1r 39 36 - - HYPH cord-317820-od9l7p1r 39 37 CoV-2 CoV-2 NNP cord-317820-od9l7p1r 39 38 to to TO cord-317820-od9l7p1r 39 39 cells cell NNS cord-317820-od9l7p1r 39 40 , , , cord-317820-od9l7p1r 39 41 respectively respectively RB cord-317820-od9l7p1r 39 42 [ [ -LRB- cord-317820-od9l7p1r 39 43 26 26 CD cord-317820-od9l7p1r 39 44 ] ] -RRB- cord-317820-od9l7p1r 39 45 . . . cord-317820-od9l7p1r 40 1 Complications complication NNS cord-317820-od9l7p1r 40 2 triggered trigger VBN cord-317820-od9l7p1r 40 3 by by IN cord-317820-od9l7p1r 40 4 COVID-19 COVID-19 NNP cord-317820-od9l7p1r 40 5 are be VBP cord-317820-od9l7p1r 40 6 the the DT cord-317820-od9l7p1r 40 7 main main JJ cord-317820-od9l7p1r 40 8 factors factor NNS cord-317820-od9l7p1r 40 9 affecting affect VBG cord-317820-od9l7p1r 40 10 disease disease NN cord-317820-od9l7p1r 40 11 severity severity NN cord-317820-od9l7p1r 40 12 and and CC cord-317820-od9l7p1r 40 13 death death NN cord-317820-od9l7p1r 40 14 ratios ratio NNS cord-317820-od9l7p1r 40 15 . . . cord-317820-od9l7p1r 41 1 The the DT cord-317820-od9l7p1r 41 2 most most RBS cord-317820-od9l7p1r 41 3 common common JJ cord-317820-od9l7p1r 41 4 complication complication NN cord-317820-od9l7p1r 41 5 of of IN cord-317820-od9l7p1r 41 6 the the DT cord-317820-od9l7p1r 41 7 COVID-19 covid-19 NN cord-317820-od9l7p1r 41 8 is be VBZ cord-317820-od9l7p1r 41 9 acute acute JJ cord-317820-od9l7p1r 41 10 respiratory respiratory JJ cord-317820-od9l7p1r 41 11 distress distress NN cord-317820-od9l7p1r 41 12 syndrome syndrome NN cord-317820-od9l7p1r 41 13 ( ( -LRB- cord-317820-od9l7p1r 41 14 ARDS ARDS NNP cord-317820-od9l7p1r 41 15 ) ) -RRB- cord-317820-od9l7p1r 41 16 . . . cord-317820-od9l7p1r 42 1 It -PRON- PRP cord-317820-od9l7p1r 42 2 is be VBZ cord-317820-od9l7p1r 42 3 characterized characterize VBN cord-317820-od9l7p1r 42 4 by by IN cord-317820-od9l7p1r 42 5 ground ground NN cord-317820-od9l7p1r 42 6 - - HYPH cord-317820-od9l7p1r 42 7 glass glass NN cord-317820-od9l7p1r 42 8 opacities opacity NNS cord-317820-od9l7p1r 42 9 appearance appearance NN cord-317820-od9l7p1r 42 10 in in IN cord-317820-od9l7p1r 42 11 the the DT cord-317820-od9l7p1r 42 12 lungs lung NNS cord-317820-od9l7p1r 42 13 and and CC cord-317820-od9l7p1r 42 14 it -PRON- PRP cord-317820-od9l7p1r 42 15 results result VBZ cord-317820-od9l7p1r 42 16 in in IN cord-317820-od9l7p1r 42 17 serious serious JJ cord-317820-od9l7p1r 42 18 respiratory respiratory JJ cord-317820-od9l7p1r 42 19 failure failure NN cord-317820-od9l7p1r 42 20 and and CC cord-317820-od9l7p1r 42 21 secondary secondary JJ cord-317820-od9l7p1r 42 22 complications complication NNS cord-317820-od9l7p1r 42 23 including include VBG cord-317820-od9l7p1r 42 24 multiple multiple JJ cord-317820-od9l7p1r 42 25 organ organ NN cord-317820-od9l7p1r 42 26 failures failure NNS cord-317820-od9l7p1r 42 27 related relate VBN cord-317820-od9l7p1r 42 28 to to IN cord-317820-od9l7p1r 42 29 insufficient insufficient JJ cord-317820-od9l7p1r 42 30 oxygenation oxygenation NN cord-317820-od9l7p1r 42 31 levels level NNS cord-317820-od9l7p1r 42 32 [ [ -LRB- cord-317820-od9l7p1r 42 33 20 20 CD cord-317820-od9l7p1r 42 34 , , , cord-317820-od9l7p1r 42 35 24 24 CD cord-317820-od9l7p1r 42 36 , , , cord-317820-od9l7p1r 42 37 27 27 CD cord-317820-od9l7p1r 42 38 ] ] -RRB- cord-317820-od9l7p1r 42 39 . . . cord-317820-od9l7p1r 43 1 Cytokine cytokine NN cord-317820-od9l7p1r 43 2 release release NN cord-317820-od9l7p1r 43 3 syndrome syndrome NN cord-317820-od9l7p1r 43 4 or or CC cord-317820-od9l7p1r 43 5 cytokine cytokine NN cord-317820-od9l7p1r 43 6 storm storm NN cord-317820-od9l7p1r 43 7 ( ( -LRB- cord-317820-od9l7p1r 43 8 See see VB cord-317820-od9l7p1r 43 9 " " `` cord-317820-od9l7p1r 43 10 4-Cytokine 4-cytokine CD cord-317820-od9l7p1r 43 11 storm storm NN cord-317820-od9l7p1r 43 12 and and CC cord-317820-od9l7p1r 43 13 COVID-19 COVID-19 NNP cord-317820-od9l7p1r 43 14 " " '' cord-317820-od9l7p1r 43 15 section section NN cord-317820-od9l7p1r 43 16 ) ) -RRB- cord-317820-od9l7p1r 43 17 , , , cord-317820-od9l7p1r 43 18 hemophagocytic hemophagocytic JJ cord-317820-od9l7p1r 43 19 lymphohistiocytosis lymphohistiocytosis NN cord-317820-od9l7p1r 43 20 , , , cord-317820-od9l7p1r 43 21 and and CC cord-317820-od9l7p1r 43 22 septic septic JJ cord-317820-od9l7p1r 43 23 shock shock NN cord-317820-od9l7p1r 43 24 are be VBP cord-317820-od9l7p1r 43 25 frequently frequently RB cord-317820-od9l7p1r 43 26 seen see VBN cord-317820-od9l7p1r 43 27 as as IN cord-317820-od9l7p1r 43 28 complications complication NNS cord-317820-od9l7p1r 43 29 from from IN cord-317820-od9l7p1r 43 30 hyperactivation hyperactivation NN cord-317820-od9l7p1r 43 31 of of IN cord-317820-od9l7p1r 43 32 the the DT cord-317820-od9l7p1r 43 33 immune immune JJ cord-317820-od9l7p1r 43 34 system system NN cord-317820-od9l7p1r 43 35 [ [ -LRB- cord-317820-od9l7p1r 43 36 28 28 CD cord-317820-od9l7p1r 43 37 ] ] -RRB- cord-317820-od9l7p1r 43 38 [ [ -LRB- cord-317820-od9l7p1r 43 39 29 29 CD cord-317820-od9l7p1r 43 40 ] ] -RRB- cord-317820-od9l7p1r 43 41 [ [ -LRB- cord-317820-od9l7p1r 43 42 30 30 CD cord-317820-od9l7p1r 43 43 ] ] -RRB- cord-317820-od9l7p1r 43 44 [ [ -LRB- cord-317820-od9l7p1r 43 45 31 31 CD cord-317820-od9l7p1r 43 46 ] ] -RRB- cord-317820-od9l7p1r 43 47 [ [ -LRB- cord-317820-od9l7p1r 43 48 32 32 CD cord-317820-od9l7p1r 43 49 ] ] -RRB- cord-317820-od9l7p1r 43 50 . . . cord-317820-od9l7p1r 44 1 Guillain Guillain NNP cord-317820-od9l7p1r 44 2 Barre Barre NNP cord-317820-od9l7p1r 44 3 Syndrome Syndrome NNP cord-317820-od9l7p1r 44 4 , , , cord-317820-od9l7p1r 44 5 hematologic hematologic JJ cord-317820-od9l7p1r 44 6 disorders disorder NNS cord-317820-od9l7p1r 44 7 like like IN cord-317820-od9l7p1r 44 8 autoimmune autoimmune JJ cord-317820-od9l7p1r 44 9 hemolytic hemolytic JJ cord-317820-od9l7p1r 44 10 anemia anemia NN cord-317820-od9l7p1r 44 11 is be VBZ cord-317820-od9l7p1r 44 12 reported report VBN cord-317820-od9l7p1r 44 13 during during IN cord-317820-od9l7p1r 44 14 COVID-19 covid-19 JJ cord-317820-od9l7p1r 44 15 treatment treatment NN cord-317820-od9l7p1r 44 16 [ [ -LRB- cord-317820-od9l7p1r 44 17 33 33 CD cord-317820-od9l7p1r 44 18 , , , cord-317820-od9l7p1r 44 19 34 34 CD cord-317820-od9l7p1r 44 20 ] ] -RRB- cord-317820-od9l7p1r 44 21 . . . cord-317820-od9l7p1r 45 1 Acute acute JJ cord-317820-od9l7p1r 45 2 cardiac cardiac NN cord-317820-od9l7p1r 45 3 , , , cord-317820-od9l7p1r 45 4 kidney kidney NN cord-317820-od9l7p1r 45 5 , , , cord-317820-od9l7p1r 45 6 and and CC cord-317820-od9l7p1r 45 7 liver liver NN cord-317820-od9l7p1r 45 8 injury injury NN cord-317820-od9l7p1r 45 9 are be VBP cord-317820-od9l7p1r 45 10 reported report VBN cord-317820-od9l7p1r 45 11 as as IN cord-317820-od9l7p1r 45 12 common common JJ cord-317820-od9l7p1r 45 13 complications complication NNS cord-317820-od9l7p1r 45 14 [ [ -LRB- cord-317820-od9l7p1r 45 15 20 20 CD cord-317820-od9l7p1r 45 16 , , , cord-317820-od9l7p1r 45 17 24 24 CD cord-317820-od9l7p1r 45 18 , , , cord-317820-od9l7p1r 45 19 27 27 CD cord-317820-od9l7p1r 45 20 ] ] -RRB- cord-317820-od9l7p1r 45 21 . . . cord-317820-od9l7p1r 46 1 Although although IN cord-317820-od9l7p1r 46 2 meningitis meningitis NN cord-317820-od9l7p1r 46 3 and and CC cord-317820-od9l7p1r 46 4 encephalitis encephalitis NN cord-317820-od9l7p1r 46 5 are be VBP cord-317820-od9l7p1r 46 6 also also RB cord-317820-od9l7p1r 46 7 reported report VBN cord-317820-od9l7p1r 46 8 as as IN cord-317820-od9l7p1r 46 9 less less JJR cord-317820-od9l7p1r 46 10 common common JJ cord-317820-od9l7p1r 46 11 complications complication NNS cord-317820-od9l7p1r 46 12 of of IN cord-317820-od9l7p1r 46 13 COVID-19 covid-19 CD cord-317820-od9l7p1r 46 14 , , , cord-317820-od9l7p1r 46 15 other other JJ cord-317820-od9l7p1r 46 16 bacterial bacterial JJ cord-317820-od9l7p1r 46 17 or or CC cord-317820-od9l7p1r 46 18 viral viral JJ cord-317820-od9l7p1r 46 19 co co NNS cord-317820-od9l7p1r 46 20 - - NNS cord-317820-od9l7p1r 46 21 infections infection NNS cord-317820-od9l7p1r 46 22 are be VBP cord-317820-od9l7p1r 46 23 quite quite RB cord-317820-od9l7p1r 46 24 often often RB cord-317820-od9l7p1r 46 25 and and CC cord-317820-od9l7p1r 46 26 they -PRON- PRP cord-317820-od9l7p1r 46 27 may may MD cord-317820-od9l7p1r 46 28 result result VB cord-317820-od9l7p1r 46 29 in in IN cord-317820-od9l7p1r 46 30 deaths death NNS cord-317820-od9l7p1r 46 31 [ [ -LRB- cord-317820-od9l7p1r 46 32 18 18 CD cord-317820-od9l7p1r 46 33 , , , cord-317820-od9l7p1r 46 34 35 35 CD cord-317820-od9l7p1r 46 35 ] ] -RRB- cord-317820-od9l7p1r 46 36 . . . cord-317820-od9l7p1r 47 1 Although although IN cord-317820-od9l7p1r 47 2 no no DT cord-317820-od9l7p1r 47 3 treatment treatment NN cord-317820-od9l7p1r 47 4 method method NN cord-317820-od9l7p1r 47 5 or or CC cord-317820-od9l7p1r 47 6 drug drug NN cord-317820-od9l7p1r 47 7 has have VBZ cord-317820-od9l7p1r 47 8 been be VBN cord-317820-od9l7p1r 47 9 approved approve VBN cord-317820-od9l7p1r 47 10 yet yet RB cord-317820-od9l7p1r 47 11 , , , cord-317820-od9l7p1r 47 12 different different JJ cord-317820-od9l7p1r 47 13 therapy therapy NN cord-317820-od9l7p1r 47 14 approaches approach NNS cord-317820-od9l7p1r 47 15 are be VBP cord-317820-od9l7p1r 47 16 using use VBG cord-317820-od9l7p1r 47 17 against against IN cord-317820-od9l7p1r 47 18 different different JJ cord-317820-od9l7p1r 47 19 symptoms symptom NNS cord-317820-od9l7p1r 47 20 of of IN cord-317820-od9l7p1r 47 21 COVID-19 covid-19 JJ cord-317820-od9l7p1r 47 22 indication indication NN cord-317820-od9l7p1r 47 23 . . . cord-317820-od9l7p1r 48 1 Current current JJ cord-317820-od9l7p1r 48 2 treatment treatment NN cord-317820-od9l7p1r 48 3 applications application NNS cord-317820-od9l7p1r 48 4 are be VBP cord-317820-od9l7p1r 48 5 separated separate VBN cord-317820-od9l7p1r 48 6 into into IN cord-317820-od9l7p1r 48 7 two two CD cord-317820-od9l7p1r 48 8 subgroups subgroup NNS cord-317820-od9l7p1r 48 9 , , , cord-317820-od9l7p1r 48 10 the the DT cord-317820-od9l7p1r 48 11 first first JJ cord-317820-od9l7p1r 48 12 group group NN cord-317820-od9l7p1r 48 13 of of IN cord-317820-od9l7p1r 48 14 the the DT cord-317820-od9l7p1r 48 15 treatment treatment NN cord-317820-od9l7p1r 48 16 strategies strategy NNS cord-317820-od9l7p1r 48 17 includes include VBZ cord-317820-od9l7p1r 48 18 antiviral antiviral JJ cord-317820-od9l7p1r 48 19 drugs drug NNS cord-317820-od9l7p1r 48 20 and and CC cord-317820-od9l7p1r 48 21 immune immune NN cord-317820-od9l7p1r 48 22 - - HYPH cord-317820-od9l7p1r 48 23 based base VBN cord-317820-od9l7p1r 48 24 therapy therapy NN cord-317820-od9l7p1r 48 25 to to TO cord-317820-od9l7p1r 48 26 overcome overcome VB cord-317820-od9l7p1r 48 27 viral viral JJ cord-317820-od9l7p1r 48 28 infection infection NN cord-317820-od9l7p1r 48 29 and and CC cord-317820-od9l7p1r 48 30 the the DT cord-317820-od9l7p1r 48 31 second second JJ cord-317820-od9l7p1r 48 32 one one NN cord-317820-od9l7p1r 48 33 comprises comprise VBZ cord-317820-od9l7p1r 48 34 antithrombotics antithrombotic NNS cord-317820-od9l7p1r 48 35 , , , cord-317820-od9l7p1r 48 36 ventilation ventilation NN cord-317820-od9l7p1r 48 37 or or CC cord-317820-od9l7p1r 48 38 oxygen oxygen NN cord-317820-od9l7p1r 48 39 therapies therapy NNS cord-317820-od9l7p1r 48 40 are be VBP cord-317820-od9l7p1r 48 41 used use VBN cord-317820-od9l7p1r 48 42 for for IN cord-317820-od9l7p1r 48 43 secondary secondary JJ cord-317820-od9l7p1r 48 44 complications complication NNS cord-317820-od9l7p1r 48 45 . . . cord-317820-od9l7p1r 49 1 It -PRON- PRP cord-317820-od9l7p1r 49 2 is be VBZ cord-317820-od9l7p1r 49 3 expected expect VBN cord-317820-od9l7p1r 49 4 that that IN cord-317820-od9l7p1r 49 5 antiviral antiviral JJ cord-317820-od9l7p1r 49 6 drugs drug NNS cord-317820-od9l7p1r 49 7 will will MD cord-317820-od9l7p1r 49 8 be be VB cord-317820-od9l7p1r 49 9 effective effective JJ cord-317820-od9l7p1r 49 10 in in IN cord-317820-od9l7p1r 49 11 COVID-19 COVID-19 NNP cord-317820-od9l7p1r 49 12 by by IN cord-317820-od9l7p1r 49 13 utilizing utilize VBG cord-317820-od9l7p1r 49 14 proven prove VBN cord-317820-od9l7p1r 49 15 and and CC cord-317820-od9l7p1r 49 16 approved approve VBN cord-317820-od9l7p1r 49 17 mechanisms mechanism NNS cord-317820-od9l7p1r 49 18 of of IN cord-317820-od9l7p1r 49 19 action action NN cord-317820-od9l7p1r 49 20 for for IN cord-317820-od9l7p1r 49 21 other other JJ cord-317820-od9l7p1r 49 22 viruses virus NNS cord-317820-od9l7p1r 49 23 . . . cord-317820-od9l7p1r 50 1 Remdesivir Remdesivir NNP cord-317820-od9l7p1r 50 2 ( ( -LRB- cord-317820-od9l7p1r 50 3 GS-5734 GS-5734 NNS cord-317820-od9l7p1r 50 4 , , , cord-317820-od9l7p1r 50 5 Gilead Gilead NNP cord-317820-od9l7p1r 50 6 Sciences Sciences NNPS cord-317820-od9l7p1r 50 7 ) ) -RRB- cord-317820-od9l7p1r 50 8 is be VBZ cord-317820-od9l7p1r 50 9 an an DT cord-317820-od9l7p1r 50 10 RNAdependent RNAdependent NNP cord-317820-od9l7p1r 50 11 RNA rna NN cord-317820-od9l7p1r 50 12 polymerase polymerase NN cord-317820-od9l7p1r 50 13 inhibitor inhibitor NN cord-317820-od9l7p1r 50 14 and and CC cord-317820-od9l7p1r 50 15 used use VBD cord-317820-od9l7p1r 50 16 against against IN cord-317820-od9l7p1r 50 17 RNA RNA NNP cord-317820-od9l7p1r 50 18 viruses virus NNS cord-317820-od9l7p1r 50 19 like like IN cord-317820-od9l7p1r 50 20 Ebolaviruses Ebolaviruses NNP cord-317820-od9l7p1r 50 21 despite despite IN cord-317820-od9l7p1r 50 22 it -PRON- PRP cord-317820-od9l7p1r 50 23 has have VBZ cord-317820-od9l7p1r 50 24 not not RB cord-317820-od9l7p1r 50 25 yet yet RB cord-317820-od9l7p1r 50 26 been be VBN cord-317820-od9l7p1r 50 27 approved approve VBN cord-317820-od9l7p1r 50 28 for for IN cord-317820-od9l7p1r 50 29 any any DT cord-317820-od9l7p1r 50 30 indication indication NN cord-317820-od9l7p1r 50 31 [ [ -LRB- cord-317820-od9l7p1r 50 32 36 36 CD cord-317820-od9l7p1r 50 33 , , , cord-317820-od9l7p1r 50 34 37 37 CD cord-317820-od9l7p1r 50 35 ] ] -RRB- cord-317820-od9l7p1r 50 36 . . . cord-317820-od9l7p1r 51 1 Chloroquine Chloroquine NNP cord-317820-od9l7p1r 51 2 ( ( -LRB- cord-317820-od9l7p1r 51 3 or or CC cord-317820-od9l7p1r 51 4 hydroxychloroquine hydroxychloroquine NNP cord-317820-od9l7p1r 51 5 ) ) -RRB- cord-317820-od9l7p1r 51 6 is be VBZ cord-317820-od9l7p1r 51 7 an an DT cord-317820-od9l7p1r 51 8 approved approve VBN cord-317820-od9l7p1r 51 9 antimalarial antimalarial JJ cord-317820-od9l7p1r 51 10 drug drug NN cord-317820-od9l7p1r 51 11 that that WDT cord-317820-od9l7p1r 51 12 increases increase VBZ cord-317820-od9l7p1r 51 13 the the DT cord-317820-od9l7p1r 51 14 pH ph NN cord-317820-od9l7p1r 51 15 of of IN cord-317820-od9l7p1r 51 16 lysosomes lysosome NNS cord-317820-od9l7p1r 51 17 thusly thusly RB cord-317820-od9l7p1r 51 18 inhibits inhibit VBZ cord-317820-od9l7p1r 51 19 autophagy autophagy NN cord-317820-od9l7p1r 51 20 by by IN cord-317820-od9l7p1r 51 21 suppressing suppress VBG cord-317820-od9l7p1r 51 22 lysosome lysosome NN cord-317820-od9l7p1r 51 23 - - HYPH cord-317820-od9l7p1r 51 24 autophagosome autophagosome JJ cord-317820-od9l7p1r 51 25 fusion fusion NN cord-317820-od9l7p1r 51 26 [ [ -LRB- cord-317820-od9l7p1r 51 27 38 38 CD cord-317820-od9l7p1r 51 28 ] ] -RRB- cord-317820-od9l7p1r 51 29 . . . cord-317820-od9l7p1r 52 1 This this DT cord-317820-od9l7p1r 52 2 autophagy autophagy NN cord-317820-od9l7p1r 52 3 inhibitor inhibitor NN cord-317820-od9l7p1r 52 4 is be VBZ cord-317820-od9l7p1r 52 5 a a DT cord-317820-od9l7p1r 52 6 part part NN cord-317820-od9l7p1r 52 7 of of IN cord-317820-od9l7p1r 52 8 the the DT cord-317820-od9l7p1r 52 9 current current JJ cord-317820-od9l7p1r 52 10 COVID-19 COVID-19 NNP cord-317820-od9l7p1r 52 11 treatment treatment NN cord-317820-od9l7p1r 52 12 protocol protocol NN cord-317820-od9l7p1r 52 13 because because IN cord-317820-od9l7p1r 52 14 it -PRON- PRP cord-317820-od9l7p1r 52 15 inhibits inhibit VBZ cord-317820-od9l7p1r 52 16 the the DT cord-317820-od9l7p1r 52 17 endocytic endocytic JJ cord-317820-od9l7p1r 52 18 pathway pathway NN cord-317820-od9l7p1r 52 19 which which WDT cord-317820-od9l7p1r 52 20 allows allow VBZ cord-317820-od9l7p1r 52 21 the the DT cord-317820-od9l7p1r 52 22 virus virus NN cord-317820-od9l7p1r 52 23 entry entry NN cord-317820-od9l7p1r 52 24 into into IN cord-317820-od9l7p1r 52 25 the the DT cord-317820-od9l7p1r 52 26 cell cell NN cord-317820-od9l7p1r 52 27 and and CC cord-317820-od9l7p1r 52 28 activation activation NN cord-317820-od9l7p1r 52 29 after after IN cord-317820-od9l7p1r 52 30 binding bind VBG cord-317820-od9l7p1r 52 31 to to IN cord-317820-od9l7p1r 52 32 the the DT cord-317820-od9l7p1r 52 33 ACE2 ACE2 NNP cord-317820-od9l7p1r 52 34 receptor receptor NN cord-317820-od9l7p1r 52 35 [ [ -LRB- cord-317820-od9l7p1r 52 36 39 39 CD cord-317820-od9l7p1r 52 37 ] ] -RRB- cord-317820-od9l7p1r 52 38 . . . cord-317820-od9l7p1r 53 1 HIV HIV NNP cord-317820-od9l7p1r 53 2 protease protease NN cord-317820-od9l7p1r 53 3 inhibitors inhibitor NNS cord-317820-od9l7p1r 53 4 are be VBP cord-317820-od9l7p1r 53 5 agents agent NNS cord-317820-od9l7p1r 53 6 that that WDT cord-317820-od9l7p1r 53 7 have have VBP cord-317820-od9l7p1r 53 8 been be VBN cord-317820-od9l7p1r 53 9 approved approve VBN cord-317820-od9l7p1r 53 10 for for IN cord-317820-od9l7p1r 53 11 use use NN cord-317820-od9l7p1r 53 12 in in IN cord-317820-od9l7p1r 53 13 the the DT cord-317820-od9l7p1r 53 14 treatment treatment NN cord-317820-od9l7p1r 53 15 of of IN cord-317820-od9l7p1r 53 16 HIV HIV NNP cord-317820-od9l7p1r 53 17 with with IN cord-317820-od9l7p1r 53 18 the the DT cord-317820-od9l7p1r 53 19 mechanism mechanism NN cord-317820-od9l7p1r 53 20 to to TO cord-317820-od9l7p1r 53 21 inhibit inhibit VB cord-317820-od9l7p1r 53 22 proteins protein NNS cord-317820-od9l7p1r 53 23 necessary necessary JJ cord-317820-od9l7p1r 53 24 to to TO cord-317820-od9l7p1r 53 25 complete complete VB cord-317820-od9l7p1r 53 26 the the DT cord-317820-od9l7p1r 53 27 life life NN cord-317820-od9l7p1r 53 28 cycle cycle NN cord-317820-od9l7p1r 53 29 of of IN cord-317820-od9l7p1r 53 30 HIV HIV NNP cord-317820-od9l7p1r 53 31 [ [ -LRB- cord-317820-od9l7p1r 53 32 40 40 CD cord-317820-od9l7p1r 53 33 ] ] -RRB- cord-317820-od9l7p1r 53 34 . . . cord-317820-od9l7p1r 54 1 It -PRON- PRP cord-317820-od9l7p1r 54 2 is be VBZ cord-317820-od9l7p1r 54 3 predicted predict VBN cord-317820-od9l7p1r 54 4 that that IN cord-317820-od9l7p1r 54 5 protease protease NN cord-317820-od9l7p1r 54 6 inhibition inhibition NN cord-317820-od9l7p1r 54 7 performed perform VBN cord-317820-od9l7p1r 54 8 with with IN cord-317820-od9l7p1r 54 9 agents agent NNS cord-317820-od9l7p1r 54 10 such such JJ cord-317820-od9l7p1r 54 11 as as IN cord-317820-od9l7p1r 54 12 Lopinavir Lopinavir NNP cord-317820-od9l7p1r 54 13 / / SYM cord-317820-od9l7p1r 54 14 Ritonavir Ritonavir NNP cord-317820-od9l7p1r 54 15 ( ( -LRB- cord-317820-od9l7p1r 54 16 Kaletra Kaletra NNP cord-317820-od9l7p1r 54 17 , , , cord-317820-od9l7p1r 54 18 Abbott Abbott NNP cord-317820-od9l7p1r 54 19 Laboratories Laboratories NNP cord-317820-od9l7p1r 54 20 ) ) -RRB- cord-317820-od9l7p1r 54 21 may may MD cord-317820-od9l7p1r 54 22 also also RB cord-317820-od9l7p1r 54 23 be be VB cord-317820-od9l7p1r 54 24 effective effective JJ cord-317820-od9l7p1r 54 25 against against IN cord-317820-od9l7p1r 54 26 SARS SARS NNP cord-317820-od9l7p1r 54 27 - - HYPH cord-317820-od9l7p1r 54 28 CoV-2 CoV-2 NNP cord-317820-od9l7p1r 54 29 [ [ -LRB- cord-317820-od9l7p1r 54 30 41 41 CD cord-317820-od9l7p1r 54 31 ] ] -RRB- cord-317820-od9l7p1r 54 32 . . . cord-317820-od9l7p1r 55 1 The the DT cord-317820-od9l7p1r 55 2 use use NN cord-317820-od9l7p1r 55 3 of of IN cord-317820-od9l7p1r 55 4 plasma plasma NN cord-317820-od9l7p1r 55 5 ( ( -LRB- cord-317820-od9l7p1r 55 6 known know VBN cord-317820-od9l7p1r 55 7 as as IN cord-317820-od9l7p1r 55 8 convalescent convalescent JJ cord-317820-od9l7p1r 55 9 plasma plasma NN cord-317820-od9l7p1r 55 10 therapy therapy NN cord-317820-od9l7p1r 55 11 ) ) -RRB- cord-317820-od9l7p1r 55 12 or or CC cord-317820-od9l7p1r 55 13 immune immune JJ cord-317820-od9l7p1r 55 14 globulins globulin NNS cord-317820-od9l7p1r 55 15 from from IN cord-317820-od9l7p1r 55 16 recovered recover VBN cord-317820-od9l7p1r 55 17 individuals individual NNS cord-317820-od9l7p1r 55 18 is be VBZ cord-317820-od9l7p1r 55 19 being be VBG cord-317820-od9l7p1r 55 20 tested test VBN cord-317820-od9l7p1r 55 21 in in IN cord-317820-od9l7p1r 55 22 clinical clinical JJ cord-317820-od9l7p1r 55 23 trials trial NNS cord-317820-od9l7p1r 55 24 to to TO cord-317820-od9l7p1r 55 25 help help VB cord-317820-od9l7p1r 55 26 activate activate VB cord-317820-od9l7p1r 55 27 the the DT cord-317820-od9l7p1r 55 28 immune immune JJ cord-317820-od9l7p1r 55 29 system system NN cord-317820-od9l7p1r 55 30 against against IN cord-317820-od9l7p1r 55 31 SARS SARS NNP cord-317820-od9l7p1r 55 32 - - HYPH cord-317820-od9l7p1r 55 33 CoV-2 CoV-2 NNP cord-317820-od9l7p1r 55 34 in in IN cord-317820-od9l7p1r 55 35 patients patient NNS cord-317820-od9l7p1r 55 36 . . . cord-317820-od9l7p1r 56 1 Also also RB cord-317820-od9l7p1r 56 2 , , , cord-317820-od9l7p1r 56 3 interferons interferon NNS cord-317820-od9l7p1r 56 4 ( ( -LRB- cord-317820-od9l7p1r 56 5 interferon interferon NNP cord-317820-od9l7p1r 56 6 alfa alfa NNP cord-317820-od9l7p1r 56 7 and and CC cord-317820-od9l7p1r 56 8 interferon interferon NNP cord-317820-od9l7p1r 56 9 beta beta NN cord-317820-od9l7p1r 56 10 ) ) -RRB- cord-317820-od9l7p1r 56 11 are be VBP cord-317820-od9l7p1r 56 12 being be VBG cord-317820-od9l7p1r 56 13 tested test VBN cord-317820-od9l7p1r 56 14 at at IN cord-317820-od9l7p1r 56 15 the the DT cord-317820-od9l7p1r 56 16 same same JJ cord-317820-od9l7p1r 56 17 purpose purpose NN cord-317820-od9l7p1r 56 18 to to TO cord-317820-od9l7p1r 56 19 activate activate VB cord-317820-od9l7p1r 56 20 the the DT cord-317820-od9l7p1r 56 21 immune immune JJ cord-317820-od9l7p1r 56 22 system system NN cord-317820-od9l7p1r 56 23 [ [ -LRB- cord-317820-od9l7p1r 56 24 42 42 CD cord-317820-od9l7p1r 56 25 ] ] -RRB- cord-317820-od9l7p1r 56 26 . . . cord-317820-od9l7p1r 57 1 The the DT cord-317820-od9l7p1r 57 2 numerous numerous JJ cord-317820-od9l7p1r 57 3 clinical clinical JJ cord-317820-od9l7p1r 57 4 studies study NNS cord-317820-od9l7p1r 57 5 that that WDT cord-317820-od9l7p1r 57 6 aim aim VBP cord-317820-od9l7p1r 57 7 to to TO cord-317820-od9l7p1r 57 8 induce induce VB cord-317820-od9l7p1r 57 9 adaptive adaptive JJ cord-317820-od9l7p1r 57 10 immunity immunity NN cord-317820-od9l7p1r 57 11 are be VBP cord-317820-od9l7p1r 57 12 maintained maintain VBN cord-317820-od9l7p1r 57 13 by by IN cord-317820-od9l7p1r 57 14 different different JJ cord-317820-od9l7p1r 57 15 research research NN cord-317820-od9l7p1r 57 16 teams team NNS cord-317820-od9l7p1r 57 17 [ [ -LRB- cord-317820-od9l7p1r 57 18 43 43 CD cord-317820-od9l7p1r 57 19 , , , cord-317820-od9l7p1r 57 20 44 44 CD cord-317820-od9l7p1r 57 21 ] ] -RRB- cord-317820-od9l7p1r 57 22 . . . cord-317820-od9l7p1r 58 1 It -PRON- PRP cord-317820-od9l7p1r 58 2 has have VBZ cord-317820-od9l7p1r 58 3 been be VBN cord-317820-od9l7p1r 58 4 reported report VBN cord-317820-od9l7p1r 58 5 that that IN cord-317820-od9l7p1r 58 6 the the DT cord-317820-od9l7p1r 58 7 infection infection NN cord-317820-od9l7p1r 58 8 - - HYPH cord-317820-od9l7p1r 58 9 related relate VBN cord-317820-od9l7p1r 58 10 increase increase NN cord-317820-od9l7p1r 58 11 of of IN cord-317820-od9l7p1r 58 12 coagulation coagulation NN cord-317820-od9l7p1r 58 13 parameters parameter NNS cord-317820-od9l7p1r 58 14 especially especially RB cord-317820-od9l7p1r 58 15 the the DT cord-317820-od9l7p1r 58 16 D d NN cord-317820-od9l7p1r 58 17 - - HYPH cord-317820-od9l7p1r 58 18 dimer dimer NN cord-317820-od9l7p1r 58 19 ( ( -LRB- cord-317820-od9l7p1r 59 1 normal normal JJ cord-317820-od9l7p1r 59 2 range range NN cord-317820-od9l7p1r 59 3 < < XX cord-317820-od9l7p1r 59 4 0.5μg 0.5μg CD cord-317820-od9l7p1r 59 5 / / SYM cord-317820-od9l7p1r 59 6 ml ml NN cord-317820-od9l7p1r 59 7 ) ) -RRB- cord-317820-od9l7p1r 59 8 is be VBZ cord-317820-od9l7p1r 59 9 directly directly RB cord-317820-od9l7p1r 59 10 proportional proportional JJ cord-317820-od9l7p1r 59 11 to to IN cord-317820-od9l7p1r 59 12 the the DT cord-317820-od9l7p1r 59 13 severity severity NN cord-317820-od9l7p1r 59 14 of of IN cord-317820-od9l7p1r 59 15 the the DT cord-317820-od9l7p1r 59 16 disease disease NN cord-317820-od9l7p1r 59 17 . . . cord-317820-od9l7p1r 60 1 Coagulation coagulation NN cord-317820-od9l7p1r 60 2 abnormalities abnormality NNS cord-317820-od9l7p1r 60 3 cause cause VBP cord-317820-od9l7p1r 60 4 disseminated disseminate VBN cord-317820-od9l7p1r 60 5 intravascular intravascular JJ cord-317820-od9l7p1r 60 6 coagulation coagulation NN cord-317820-od9l7p1r 60 7 and and CC cord-317820-od9l7p1r 60 8 it -PRON- PRP cord-317820-od9l7p1r 60 9 triggers trigger VBZ cord-317820-od9l7p1r 60 10 venous venous JJ cord-317820-od9l7p1r 60 11 thromboembolism thromboembolism NN cord-317820-od9l7p1r 60 12 and and CC cord-317820-od9l7p1r 60 13 pulmonary pulmonary JJ cord-317820-od9l7p1r 60 14 embolism embolism NN cord-317820-od9l7p1r 60 15 which which WDT cord-317820-od9l7p1r 60 16 are be VBP cord-317820-od9l7p1r 60 17 among among IN cord-317820-od9l7p1r 60 18 the the DT cord-317820-od9l7p1r 60 19 main main JJ cord-317820-od9l7p1r 60 20 COVID-19 COVID-19 NNP cord-317820-od9l7p1r 60 21 related related JJ cord-317820-od9l7p1r 60 22 death death NN cord-317820-od9l7p1r 60 23 reasons reason NNS cord-317820-od9l7p1r 60 24 . . . cord-317820-od9l7p1r 61 1 Antithrombotic antithrombotic JJ cord-317820-od9l7p1r 61 2 and and CC cord-317820-od9l7p1r 61 3 anticoagulant anticoagulant JJ cord-317820-od9l7p1r 61 4 drugs drug NNS cord-317820-od9l7p1r 61 5 including include VBG cord-317820-od9l7p1r 61 6 heparin heparin VBN cord-317820-od9l7p1r 61 7 , , , cord-317820-od9l7p1r 61 8 warfarin warfarin NN cord-317820-od9l7p1r 61 9 , , , cord-317820-od9l7p1r 61 10 direct direct JJ cord-317820-od9l7p1r 61 11 - - HYPH cord-317820-od9l7p1r 61 12 acting act VBG cord-317820-od9l7p1r 61 13 oral oral JJ cord-317820-od9l7p1r 61 14 anticoagulants anticoagulant NNS cord-317820-od9l7p1r 61 15 are be VBP cord-317820-od9l7p1r 61 16 used use VBN cord-317820-od9l7p1r 61 17 against against IN cord-317820-od9l7p1r 61 18 the the DT cord-317820-od9l7p1r 61 19 development development NN cord-317820-od9l7p1r 61 20 of of IN cord-317820-od9l7p1r 61 21 coagulation coagulation NN cord-317820-od9l7p1r 61 22 and and CC cord-317820-od9l7p1r 61 23 thromboembolism thromboembolism NN cord-317820-od9l7p1r 61 24 during during IN cord-317820-od9l7p1r 61 25 the the DT cord-317820-od9l7p1r 61 26 treatment treatment NN cord-317820-od9l7p1r 61 27 process process NN cord-317820-od9l7p1r 61 28 [ [ -LRB- cord-317820-od9l7p1r 61 29 45 45 CD cord-317820-od9l7p1r 61 30 ] ] -RRB- cord-317820-od9l7p1r 61 31 . . . cord-317820-od9l7p1r 62 1 Various various JJ cord-317820-od9l7p1r 62 2 genetic genetic JJ cord-317820-od9l7p1r 62 3 alterations alteration NNS cord-317820-od9l7p1r 62 4 which which WDT cord-317820-od9l7p1r 62 5 will will MD cord-317820-od9l7p1r 62 6 be be VB cord-317820-od9l7p1r 62 7 used use VBN cord-317820-od9l7p1r 62 8 as as IN cord-317820-od9l7p1r 62 9 therapeutic therapeutic JJ cord-317820-od9l7p1r 62 10 targets target NNS cord-317820-od9l7p1r 62 11 are be VBP cord-317820-od9l7p1r 62 12 reported report VBN cord-317820-od9l7p1r 62 13 during during IN cord-317820-od9l7p1r 62 14 COVID-19 covid-19 CD cord-317820-od9l7p1r 62 15 infection infection NN cord-317820-od9l7p1r 62 16 ( ( -LRB- cord-317820-od9l7p1r 62 17 Figure figure NN cord-317820-od9l7p1r 62 18 2 2 CD cord-317820-od9l7p1r 62 19 ) ) -RRB- cord-317820-od9l7p1r 62 20 . . . cord-317820-od9l7p1r 63 1 The the DT cord-317820-od9l7p1r 63 2 variations variation NNS cord-317820-od9l7p1r 63 3 especially especially RB cord-317820-od9l7p1r 63 4 include include VBP cord-317820-od9l7p1r 63 5 inflammation inflammation NN cord-317820-od9l7p1r 63 6 and and CC cord-317820-od9l7p1r 63 7 immune immune JJ cord-317820-od9l7p1r 63 8 response response NN cord-317820-od9l7p1r 63 9 regulation regulation NN cord-317820-od9l7p1r 63 10 [ [ -LRB- cord-317820-od9l7p1r 63 11 10 10 CD cord-317820-od9l7p1r 63 12 , , , cord-317820-od9l7p1r 63 13 11 11 CD cord-317820-od9l7p1r 63 14 , , , cord-317820-od9l7p1r 63 15 [ [ -LRB- cord-317820-od9l7p1r 63 16 13 13 CD cord-317820-od9l7p1r 63 17 ] ] -RRB- cord-317820-od9l7p1r 63 18 [ [ -LRB- cord-317820-od9l7p1r 63 19 14 14 CD cord-317820-od9l7p1r 63 20 ] ] -RRB- cord-317820-od9l7p1r 63 21 [ [ -LRB- cord-317820-od9l7p1r 63 22 15 15 CD cord-317820-od9l7p1r 63 23 ] ] -RRB- cord-317820-od9l7p1r 63 24 [ [ -LRB- cord-317820-od9l7p1r 63 25 16 16 CD cord-317820-od9l7p1r 63 26 ] ] -RRB- cord-317820-od9l7p1r 63 27 [ [ -LRB- cord-317820-od9l7p1r 63 28 17 17 CD cord-317820-od9l7p1r 63 29 ] ] -RRB- cord-317820-od9l7p1r 63 30 19 19 CD cord-317820-od9l7p1r 63 31 , , , cord-317820-od9l7p1r 63 32 24 24 CD cord-317820-od9l7p1r 63 33 , , , cord-317820-od9l7p1r 63 34 27 27 CD cord-317820-od9l7p1r 63 35 , , , cord-317820-od9l7p1r 63 36 29 29 CD cord-317820-od9l7p1r 63 37 , , , cord-317820-od9l7p1r 63 38 31 31 CD cord-317820-od9l7p1r 63 39 , , , cord-317820-od9l7p1r 63 40 32 32 CD cord-317820-od9l7p1r 63 41 , , , cord-317820-od9l7p1r 63 42 [ [ -LRB- cord-317820-od9l7p1r 63 43 46 46 CD cord-317820-od9l7p1r 63 44 ] ] -RRB- cord-317820-od9l7p1r 63 45 [ [ -LRB- cord-317820-od9l7p1r 63 46 47 47 CD cord-317820-od9l7p1r 63 47 ] ] -RRB- cord-317820-od9l7p1r 63 48 [ [ -LRB- cord-317820-od9l7p1r 63 49 48 48 CD cord-317820-od9l7p1r 63 50 ] ] -RRB- cord-317820-od9l7p1r 63 51 [ [ -LRB- cord-317820-od9l7p1r 63 52 49 49 CD cord-317820-od9l7p1r 63 53 ] ] -RRB- cord-317820-od9l7p1r 63 54 [ [ -LRB- cord-317820-od9l7p1r 63 55 50 50 CD cord-317820-od9l7p1r 63 56 ] ] -RRB- cord-317820-od9l7p1r 63 57 [ [ -LRB- cord-317820-od9l7p1r 63 58 51 51 CD cord-317820-od9l7p1r 63 59 ] ] -RRB- cord-317820-od9l7p1r 63 60 [ [ -LRB- cord-317820-od9l7p1r 63 61 52 52 CD cord-317820-od9l7p1r 63 62 ] ] -RRB- cord-317820-od9l7p1r 63 63 [ [ -LRB- cord-317820-od9l7p1r 63 64 53 53 CD cord-317820-od9l7p1r 63 65 ] ] -RRB- cord-317820-od9l7p1r 63 66 . . . cord-317820-od9l7p1r 64 1 Upregulation upregulation NN cord-317820-od9l7p1r 64 2 and and CC cord-317820-od9l7p1r 64 3 overexpression overexpression NN cord-317820-od9l7p1r 64 4 of of IN cord-317820-od9l7p1r 64 5 ACE2 ACE2 NNP cord-317820-od9l7p1r 64 6 and and CC cord-317820-od9l7p1r 64 7 TMPRSS2 TMPRSS2 NNP cord-317820-od9l7p1r 64 8 may may MD cord-317820-od9l7p1r 64 9 be be VB cord-317820-od9l7p1r 64 10 potential potential JJ cord-317820-od9l7p1r 64 11 reasons reason NNS cord-317820-od9l7p1r 64 12 for for IN cord-317820-od9l7p1r 64 13 virus virus NN cord-317820-od9l7p1r 64 14 absorption absorption NN cord-317820-od9l7p1r 64 15 and and CC cord-317820-od9l7p1r 64 16 complications complication NNS cord-317820-od9l7p1r 64 17 in in IN cord-317820-od9l7p1r 64 18 the the DT cord-317820-od9l7p1r 64 19 heart heart NN cord-317820-od9l7p1r 64 20 , , , cord-317820-od9l7p1r 64 21 lungs lung NNS cord-317820-od9l7p1r 64 22 , , , cord-317820-od9l7p1r 64 23 and and CC cord-317820-od9l7p1r 64 24 different different JJ cord-317820-od9l7p1r 64 25 organs organ NNS cord-317820-od9l7p1r 64 26 related relate VBN cord-317820-od9l7p1r 64 27 to to IN cord-317820-od9l7p1r 64 28 the the DT cord-317820-od9l7p1r 64 29 nervous nervous JJ cord-317820-od9l7p1r 64 30 system system NN cord-317820-od9l7p1r 64 31 [ [ -LRB- cord-317820-od9l7p1r 64 32 47 47 CD cord-317820-od9l7p1r 64 33 , , , cord-317820-od9l7p1r 64 34 54 54 CD cord-317820-od9l7p1r 64 35 ] ] -RRB- cord-317820-od9l7p1r 64 36 . . . cord-317820-od9l7p1r 65 1 As as IN cord-317820-od9l7p1r 65 2 an an DT cord-317820-od9l7p1r 65 3 expected expected JJ cord-317820-od9l7p1r 65 4 result result NN cord-317820-od9l7p1r 65 5 of of IN cord-317820-od9l7p1r 65 6 SARS SARS NNP cord-317820-od9l7p1r 65 7 - - HYPH cord-317820-od9l7p1r 65 8 CoV-2 CoV-2 NNP cord-317820-od9l7p1r 65 9 infection infection NN cord-317820-od9l7p1r 65 10 , , , cord-317820-od9l7p1r 65 11 it -PRON- PRP cord-317820-od9l7p1r 65 12 was be VBD cord-317820-od9l7p1r 65 13 reported report VBN cord-317820-od9l7p1r 65 14 cytokine cytokine NN cord-317820-od9l7p1r 65 15 storm storm NN cord-317820-od9l7p1r 65 16 syndrome syndrome NN cord-317820-od9l7p1r 65 17 triggered trigger VBN cord-317820-od9l7p1r 65 18 by by IN cord-317820-od9l7p1r 65 19 the the DT cord-317820-od9l7p1r 65 20 dysregulated dysregulate VBN cord-317820-od9l7p1r 65 21 immunity immunity NN cord-317820-od9l7p1r 65 22 in in IN cord-317820-od9l7p1r 65 23 numerous numerous JJ cord-317820-od9l7p1r 65 24 patients patient NNS cord-317820-od9l7p1r 65 25 . . . cord-317820-od9l7p1r 66 1 Cytokine cytokine NN cord-317820-od9l7p1r 66 2 storm storm NN cord-317820-od9l7p1r 66 3 is be VBZ cord-317820-od9l7p1r 66 4 characterized characterize VBN cord-317820-od9l7p1r 66 5 by by IN cord-317820-od9l7p1r 66 6 high high JJ cord-317820-od9l7p1r 66 7 inflammatory inflammatory JJ cord-317820-od9l7p1r 66 8 response response NN cord-317820-od9l7p1r 66 9 including include VBG cord-317820-od9l7p1r 66 10 elevated elevated JJ cord-317820-od9l7p1r 66 11 levels level NNS cord-317820-od9l7p1r 66 12 of of IN cord-317820-od9l7p1r 66 13 cytokines cytokine NNS cord-317820-od9l7p1r 66 14 and and CC cord-317820-od9l7p1r 66 15 immune immune JJ cord-317820-od9l7p1r 66 16 cells cell NNS cord-317820-od9l7p1r 66 17 which which WDT cord-317820-od9l7p1r 66 18 infiltrates infiltrate VBZ cord-317820-od9l7p1r 66 19 and and CC cord-317820-od9l7p1r 66 20 destroys destroy VBZ cord-317820-od9l7p1r 66 21 the the DT cord-317820-od9l7p1r 66 22 organs organ NNS cord-317820-od9l7p1r 66 23 and and CC cord-317820-od9l7p1r 66 24 causes cause VBZ cord-317820-od9l7p1r 66 25 lung lung NN cord-317820-od9l7p1r 66 26 lesions lesion NNS cord-317820-od9l7p1r 66 27 , , , cord-317820-od9l7p1r 66 28 respiratory respiratory JJ cord-317820-od9l7p1r 66 29 dysfunction dysfunction NN cord-317820-od9l7p1r 66 30 , , , cord-317820-od9l7p1r 66 31 multiple multiple JJ cord-317820-od9l7p1r 66 32 organ organ NN cord-317820-od9l7p1r 66 33 damage damage NN cord-317820-od9l7p1r 66 34 , , , cord-317820-od9l7p1r 66 35 and and CC cord-317820-od9l7p1r 66 36 death death NN cord-317820-od9l7p1r 66 37 [ [ -LRB- cord-317820-od9l7p1r 66 38 28 28 CD cord-317820-od9l7p1r 66 39 ] ] -RRB- cord-317820-od9l7p1r 66 40 . . . cord-317820-od9l7p1r 67 1 Cytokines cytokine NNS cord-317820-od9l7p1r 67 2 are be VBP cord-317820-od9l7p1r 67 3 a a DT cord-317820-od9l7p1r 67 4 group group NN cord-317820-od9l7p1r 67 5 of of IN cord-317820-od9l7p1r 67 6 immunoregulatory immunoregulatory JJ cord-317820-od9l7p1r 67 7 cell cell NN cord-317820-od9l7p1r 67 8 - - HYPH cord-317820-od9l7p1r 67 9 cell cell NN cord-317820-od9l7p1r 67 10 communication communication NN cord-317820-od9l7p1r 67 11 molecules molecule NNS cord-317820-od9l7p1r 67 12 including include VBG cord-317820-od9l7p1r 67 13 different different JJ cord-317820-od9l7p1r 67 14 subtypes subtype NNS cord-317820-od9l7p1r 67 15 named name VBN cord-317820-od9l7p1r 67 16 chemokine chemokine NN cord-317820-od9l7p1r 67 17 ( ( -LRB- cord-317820-od9l7p1r 67 18 chemotaxis chemotaxis NN cord-317820-od9l7p1r 67 19 cytokine cytokine NN cord-317820-od9l7p1r 67 20 ) ) -RRB- cord-317820-od9l7p1r 67 21 , , , cord-317820-od9l7p1r 67 22 interleukin interleukin FW cord-317820-od9l7p1r 67 23 ( ( -LRB- cord-317820-od9l7p1r 67 24 leukocyte leukocyte NN cord-317820-od9l7p1r 67 25 related relate VBN cord-317820-od9l7p1r 67 26 cytokine cytokine NN cord-317820-od9l7p1r 67 27 ) ) -RRB- cord-317820-od9l7p1r 67 28 , , , cord-317820-od9l7p1r 67 29 lymphokine lymphokine NN cord-317820-od9l7p1r 67 30 ( ( -LRB- cord-317820-od9l7p1r 67 31 lymphocytes lymphocytes NN cord-317820-od9l7p1r 67 32 - - HYPH cord-317820-od9l7p1r 67 33 related relate VBN cord-317820-od9l7p1r 67 34 cytokine cytokine NN cord-317820-od9l7p1r 67 35 ) ) -RRB- cord-317820-od9l7p1r 67 36 , , , cord-317820-od9l7p1r 67 37 monokine monokine NNP cord-317820-od9l7p1r 67 38 ( ( -LRB- cord-317820-od9l7p1r 67 39 monocytes monocyte VBZ cord-317820-od9l7p1r 67 40 - - HYPH cord-317820-od9l7p1r 67 41 related relate VBN cord-317820-od9l7p1r 67 42 cytokine cytokine NN cord-317820-od9l7p1r 67 43 ) ) -RRB- cord-317820-od9l7p1r 67 44 and and CC cord-317820-od9l7p1r 67 45 interferons interferon NNS cord-317820-od9l7p1r 67 46 . . . cord-317820-od9l7p1r 68 1 Initially initially RB cord-317820-od9l7p1r 68 2 , , , cord-317820-od9l7p1r 68 3 although although IN cord-317820-od9l7p1r 68 4 it -PRON- PRP cord-317820-od9l7p1r 68 5 was be VBD cord-317820-od9l7p1r 68 6 thought think VBN cord-317820-od9l7p1r 68 7 that that IN cord-317820-od9l7p1r 68 8 they -PRON- PRP cord-317820-od9l7p1r 68 9 were be VBD cord-317820-od9l7p1r 68 10 secreted secrete VBN cord-317820-od9l7p1r 68 11 by by IN cord-317820-od9l7p1r 68 12 only only JJ cord-317820-od9l7p1r 68 13 specific specific JJ cord-317820-od9l7p1r 68 14 immune immune JJ cord-317820-od9l7p1r 68 15 cells cell NNS cord-317820-od9l7p1r 68 16 and and CC cord-317820-od9l7p1r 68 17 effected effect VBN cord-317820-od9l7p1r 68 18 only only RB cord-317820-od9l7p1r 68 19 limited limited JJ cord-317820-od9l7p1r 68 20 cell cell NN cord-317820-od9l7p1r 68 21 types type NNS cord-317820-od9l7p1r 68 22 , , , cord-317820-od9l7p1r 68 23 it -PRON- PRP cord-317820-od9l7p1r 68 24 is be VBZ cord-317820-od9l7p1r 68 25 known know VBN cord-317820-od9l7p1r 68 26 that that IN cord-317820-od9l7p1r 68 27 they -PRON- PRP cord-317820-od9l7p1r 68 28 are be VBP cord-317820-od9l7p1r 68 29 secreted secrete VBN cord-317820-od9l7p1r 68 30 by by IN cord-317820-od9l7p1r 68 31 nonimmune nonimmune JJ cord-317820-od9l7p1r 68 32 cells cell NNS cord-317820-od9l7p1r 68 33 fibroblasts fibroblast NNS cord-317820-od9l7p1r 68 34 or or CC cord-317820-od9l7p1r 68 35 endothelial endothelial JJ cord-317820-od9l7p1r 68 36 cells cell NNS cord-317820-od9l7p1r 68 37 to to TO cord-317820-od9l7p1r 68 38 respond respond VB cord-317820-od9l7p1r 68 39 inflammation inflammation NN cord-317820-od9l7p1r 68 40 or or CC cord-317820-od9l7p1r 68 41 injury injury NN cord-317820-od9l7p1r 68 42 in in IN cord-317820-od9l7p1r 68 43 addition addition NN cord-317820-od9l7p1r 68 44 to to IN cord-317820-od9l7p1r 68 45 immune immune JJ cord-317820-od9l7p1r 68 46 cells cell NNS cord-317820-od9l7p1r 68 47 like like IN cord-317820-od9l7p1r 68 48 monocytes monocyte NNS cord-317820-od9l7p1r 68 49 , , , cord-317820-od9l7p1r 68 50 macrophages macrophage NNS cord-317820-od9l7p1r 68 51 , , , cord-317820-od9l7p1r 68 52 B b NN cord-317820-od9l7p1r 68 53 - - : cord-317820-od9l7p1r 68 54 and and CC cord-317820-od9l7p1r 68 55 T t NN cord-317820-od9l7p1r 68 56 - - HYPH cord-317820-od9l7p1r 68 57 lymphocytes lymphocyte NNS cord-317820-od9l7p1r 68 58 . . . cord-317820-od9l7p1r 69 1 The the DT cord-317820-od9l7p1r 69 2 cytokines cytokine NNS cord-317820-od9l7p1r 69 3 are be VBP cord-317820-od9l7p1r 69 4 both both DT cord-317820-od9l7p1r 69 5 cause cause VBP cord-317820-od9l7p1r 69 6 and and CC cord-317820-od9l7p1r 69 7 result result NN cord-317820-od9l7p1r 69 8 of of IN cord-317820-od9l7p1r 69 9 the the DT cord-317820-od9l7p1r 69 10 immune immune JJ cord-317820-od9l7p1r 69 11 response response NN cord-317820-od9l7p1r 70 1 and and CC cord-317820-od9l7p1r 70 2 they -PRON- PRP cord-317820-od9l7p1r 70 3 include include VBP cord-317820-od9l7p1r 70 4 both both DT cord-317820-od9l7p1r 70 5 pro pro JJ cord-317820-od9l7p1r 70 6 - - JJ cord-317820-od9l7p1r 70 7 and and CC cord-317820-od9l7p1r 70 8 anti anti JJ cord-317820-od9l7p1r 70 9 - - JJ cord-317820-od9l7p1r 70 10 inflammatory inflammatory JJ cord-317820-od9l7p1r 70 11 molecules molecule NNS cord-317820-od9l7p1r 70 12 [ [ -LRB- cord-317820-od9l7p1r 70 13 55 55 CD cord-317820-od9l7p1r 70 14 ] ] -RRB- cord-317820-od9l7p1r 70 15 . . . cord-317820-od9l7p1r 71 1 Cytokines Cytokines NNPS cord-317820-od9l7p1r 71 2 both both DT cord-317820-od9l7p1r 71 3 regulate regulate VBP cord-317820-od9l7p1r 71 4 different different JJ cord-317820-od9l7p1r 71 5 cellular cellular JJ cord-317820-od9l7p1r 71 6 responses response NNS cord-317820-od9l7p1r 71 7 and and CC cord-317820-od9l7p1r 71 8 their -PRON- PRP$ cord-317820-od9l7p1r 71 9 activation activation NN cord-317820-od9l7p1r 71 10 is be VBZ cord-317820-od9l7p1r 71 11 controlled control VBN cord-317820-od9l7p1r 71 12 by by IN cord-317820-od9l7p1r 71 13 molecular molecular JJ cord-317820-od9l7p1r 71 14 signaling signal VBG cord-317820-od9l7p1r 71 15 pathways pathway NNS cord-317820-od9l7p1r 71 16 . . . cord-317820-od9l7p1r 72 1 JAK/ JAK/ NNP cord-317820-od9l7p1r 72 2 STAT stat NN cord-317820-od9l7p1r 72 3 pathway pathway NN cord-317820-od9l7p1r 72 4 is be VBZ cord-317820-od9l7p1r 72 5 primarily primarily RB cord-317820-od9l7p1r 72 6 responsible responsible JJ cord-317820-od9l7p1r 72 7 for for IN cord-317820-od9l7p1r 72 8 main main JJ cord-317820-od9l7p1r 72 9 cytokine cytokine NN cord-317820-od9l7p1r 72 10 production production NN cord-317820-od9l7p1r 72 11 and and CC cord-317820-od9l7p1r 72 12 immune immune JJ cord-317820-od9l7p1r 72 13 response response NN cord-317820-od9l7p1r 72 14 regulation regulation NN cord-317820-od9l7p1r 72 15 [ [ -LRB- cord-317820-od9l7p1r 72 16 56 56 CD cord-317820-od9l7p1r 72 17 ] ] -RRB- cord-317820-od9l7p1r 72 18 . . . cord-317820-od9l7p1r 73 1 The the DT cord-317820-od9l7p1r 73 2 Janus Janus NNP cord-317820-od9l7p1r 73 3 kinases kinase NNS cord-317820-od9l7p1r 73 4 ( ( -LRB- cord-317820-od9l7p1r 73 5 JAKs JAKs NNP cord-317820-od9l7p1r 73 6 ) ) -RRB- cord-317820-od9l7p1r 73 7 and and CC cord-317820-od9l7p1r 73 8 the the DT cord-317820-od9l7p1r 73 9 signal signal NN cord-317820-od9l7p1r 73 10 transducers transducer NNS cord-317820-od9l7p1r 73 11 and and CC cord-317820-od9l7p1r 73 12 activators activator NNS cord-317820-od9l7p1r 73 13 of of IN cord-317820-od9l7p1r 73 14 transcriptions transcription NNS cord-317820-od9l7p1r 73 15 ( ( -LRB- cord-317820-od9l7p1r 73 16 STATs stat NNS cord-317820-od9l7p1r 73 17 ) ) -RRB- cord-317820-od9l7p1r 73 18 form form VB cord-317820-od9l7p1r 73 19 one one CD cord-317820-od9l7p1r 73 20 of of IN cord-317820-od9l7p1r 73 21 the the DT cord-317820-od9l7p1r 73 22 main main JJ cord-317820-od9l7p1r 73 23 regulator regulator NN cord-317820-od9l7p1r 73 24 cell cell NN cord-317820-od9l7p1r 73 25 signaling signal VBG cord-317820-od9l7p1r 73 26 pathway pathway NN cord-317820-od9l7p1r 73 27 named name VBN cord-317820-od9l7p1r 73 28 as as IN cord-317820-od9l7p1r 73 29 JAK JAK NNP cord-317820-od9l7p1r 73 30 / / SYM cord-317820-od9l7p1r 73 31 STAT stat NN cord-317820-od9l7p1r 73 32 pathway pathway NN cord-317820-od9l7p1r 73 33 ( ( -LRB- cord-317820-od9l7p1r 73 34 Figure figure NN cord-317820-od9l7p1r 73 35 4 4 CD cord-317820-od9l7p1r 73 36 ) ) -RRB- cord-317820-od9l7p1r 73 37 . . . cord-317820-od9l7p1r 74 1 JAK JAK NNP cord-317820-od9l7p1r 74 2 nonreceptor nonreceptor NNP cord-317820-od9l7p1r 74 3 tyrosine tyrosine NNP cord-317820-od9l7p1r 74 4 kinase kinase NN cord-317820-od9l7p1r 74 5 family family NN cord-317820-od9l7p1r 74 6 includes include VBZ cord-317820-od9l7p1r 74 7 Jak1 Jak1 NNP cord-317820-od9l7p1r 74 8 , , , cord-317820-od9l7p1r 74 9 Jak2 Jak2 NNP cord-317820-od9l7p1r 74 10 , , , cord-317820-od9l7p1r 74 11 Jak3 Jak3 NNP cord-317820-od9l7p1r 74 12 , , , cord-317820-od9l7p1r 74 13 and and CC cord-317820-od9l7p1r 74 14 Tyrosine Tyrosine NNP cord-317820-od9l7p1r 74 15 kinase kinase NN cord-317820-od9l7p1r 74 16 2 2 CD cord-317820-od9l7p1r 74 17 ( ( -LRB- cord-317820-od9l7p1r 74 18 Tyk2 Tyk2 NNP cord-317820-od9l7p1r 74 19 ) ) -RRB- cord-317820-od9l7p1r 74 20 proteins protein NNS cord-317820-od9l7p1r 74 21 . . . cord-317820-od9l7p1r 75 1 Their -PRON- PRP$ cord-317820-od9l7p1r 75 2 ( ( -LRB- cord-317820-od9l7p1r 75 3 TAD tad NN cord-317820-od9l7p1r 75 4 ) ) -RRB- cord-317820-od9l7p1r 75 5 ( ( -LRB- cord-317820-od9l7p1r 75 6 carries carry VBZ cord-317820-od9l7p1r 75 7 conserved conserved JJ cord-317820-od9l7p1r 75 8 tyrosine tyrosine NN cord-317820-od9l7p1r 75 9 residues residue NNS cord-317820-od9l7p1r 75 10 which which WDT cord-317820-od9l7p1r 75 11 is be VBZ cord-317820-od9l7p1r 75 12 phosphorylation phosphorylation NN cord-317820-od9l7p1r 75 13 sites site NNS cord-317820-od9l7p1r 75 14 ) ) -RRB- cord-317820-od9l7p1r 75 15 domains domain NNS cord-317820-od9l7p1r 75 16 [ [ -LRB- cord-317820-od9l7p1r 75 17 58 58 CD cord-317820-od9l7p1r 75 18 ] ] -RRB- cord-317820-od9l7p1r 75 19 . . . cord-317820-od9l7p1r 76 1 According accord VBG cord-317820-od9l7p1r 76 2 to to IN cord-317820-od9l7p1r 76 3 the the DT cord-317820-od9l7p1r 76 4 message message NN cord-317820-od9l7p1r 76 5 the the DT cord-317820-od9l7p1r 76 6 cell cell NN cord-317820-od9l7p1r 76 7 regulates regulate VBZ cord-317820-od9l7p1r 76 8 critical critical JJ cord-317820-od9l7p1r 76 9 processes process NNS cord-317820-od9l7p1r 76 10 as as IN cord-317820-od9l7p1r 76 11 proliferation proliferation NN cord-317820-od9l7p1r 76 12 , , , cord-317820-od9l7p1r 76 13 differentiation differentiation NN cord-317820-od9l7p1r 76 14 , , , cord-317820-od9l7p1r 76 15 migration migration NN cord-317820-od9l7p1r 76 16 , , , cord-317820-od9l7p1r 76 17 apoptosis apoptosis NN cord-317820-od9l7p1r 76 18 and and CC cord-317820-od9l7p1r 76 19 these these DT cord-317820-od9l7p1r 76 20 responses response NNS cord-317820-od9l7p1r 76 21 underlie underlie VBP cord-317820-od9l7p1r 76 22 critical critical JJ cord-317820-od9l7p1r 76 23 components component NNS cord-317820-od9l7p1r 76 24 of of IN cord-317820-od9l7p1r 76 25 cellular cellular JJ cord-317820-od9l7p1r 76 26 homeostasis homeostasis NN cord-317820-od9l7p1r 76 27 [ [ -LRB- cord-317820-od9l7p1r 76 28 59 59 CD cord-317820-od9l7p1r 76 29 ] ] -RRB- cord-317820-od9l7p1r 76 30 . . . cord-317820-od9l7p1r 77 1 The the DT cord-317820-od9l7p1r 77 2 IL6 IL6 NNP cord-317820-od9l7p1r 77 3 / / SYM cord-317820-od9l7p1r 77 4 JAK JAK NNP cord-317820-od9l7p1r 77 5 / / SYM cord-317820-od9l7p1r 77 6 STAT3 STAT3 NNP cord-317820-od9l7p1r 77 7 signaling signal VBG cord-317820-od9l7p1r 77 8 pathway pathway NN cord-317820-od9l7p1r 77 9 is be VBZ cord-317820-od9l7p1r 77 10 a a DT cord-317820-od9l7p1r 77 11 specific specific JJ cord-317820-od9l7p1r 77 12 subtype subtype NN cord-317820-od9l7p1r 77 13 of of IN cord-317820-od9l7p1r 77 14 the the DT cord-317820-od9l7p1r 77 15 JAK JAK NNP cord-317820-od9l7p1r 77 16 / / SYM cord-317820-od9l7p1r 77 17 STAT stat NN cord-317820-od9l7p1r 77 18 pathway pathway NN cord-317820-od9l7p1r 77 19 that that WDT cord-317820-od9l7p1r 77 20 includes include VBZ cord-317820-od9l7p1r 77 21 IL6 il6 NN cord-317820-od9l7p1r 77 22 which which WDT cord-317820-od9l7p1r 77 23 is be VBZ cord-317820-od9l7p1r 77 24 an an DT cord-317820-od9l7p1r 77 25 essential essential JJ cord-317820-od9l7p1r 77 26 pleiotropic pleiotropic JJ cord-317820-od9l7p1r 77 27 cytokine cytokine NN cord-317820-od9l7p1r 77 28 produced produce VBN cord-317820-od9l7p1r 77 29 by by IN cord-317820-od9l7p1r 77 30 immune immune JJ cord-317820-od9l7p1r 77 31 cells cell NNS cord-317820-od9l7p1r 77 32 like like IN cord-317820-od9l7p1r 77 33 B b NN cord-317820-od9l7p1r 77 34 cells cell NNS cord-317820-od9l7p1r 77 35 T t NN cord-317820-od9l7p1r 77 36 cells cell NNS cord-317820-od9l7p1r 77 37 , , , cord-317820-od9l7p1r 77 38 dendritic dendritic JJ cord-317820-od9l7p1r 77 39 cells cell NNS cord-317820-od9l7p1r 77 40 , , , cord-317820-od9l7p1r 77 41 macrophages macrophage NNS cord-317820-od9l7p1r 77 42 to to TO cord-317820-od9l7p1r 77 43 create create VB cord-317820-od9l7p1r 77 44 an an DT cord-317820-od9l7p1r 77 45 immune immune NN cord-317820-od9l7p1r 77 46 response/ response/ HYPH cord-317820-od9l7p1r 77 47 inflammation inflammation NN cord-317820-od9l7p1r 77 48 . . . cord-317820-od9l7p1r 78 1 Binding bind VBG cord-317820-od9l7p1r 78 2 of of IN cord-317820-od9l7p1r 78 3 IL6 il6 NN cord-317820-od9l7p1r 78 4 to to IN cord-317820-od9l7p1r 78 5 its -PRON- PRP$ cord-317820-od9l7p1r 78 6 specific specific JJ cord-317820-od9l7p1r 78 7 receptor receptor NN cord-317820-od9l7p1r 78 8 ( ( -LRB- cord-317820-od9l7p1r 78 9 IL6 il6 NN cord-317820-od9l7p1r 78 10 receptor receptor NN cord-317820-od9l7p1r 78 11 - - HYPH cord-317820-od9l7p1r 78 12 subunit subunit NN cord-317820-od9l7p1r 78 13 alpha alpha NN cord-317820-od9l7p1r 78 14 IL6R IL6R NNP cord-317820-od9l7p1r 78 15 ) ) -RRB- cord-317820-od9l7p1r 78 16 triggers trigger VBZ cord-317820-od9l7p1r 78 17 a a DT cord-317820-od9l7p1r 78 18 form form NN cord-317820-od9l7p1r 78 19 of of IN cord-317820-od9l7p1r 78 20 a a DT cord-317820-od9l7p1r 78 21 heterohexameric heterohexameric JJ cord-317820-od9l7p1r 78 22 complex complex NN cord-317820-od9l7p1r 78 23 with with IN cord-317820-od9l7p1r 78 24 IL6 il6 NN cord-317820-od9l7p1r 78 25 receptor receptor NN cord-317820-od9l7p1r 78 26 subunit subunit NN cord-317820-od9l7p1r 78 27 - - HYPH cord-317820-od9l7p1r 78 28 β β NN cord-317820-od9l7p1r 78 29 ( ( -LRB- cord-317820-od9l7p1r 78 30 gp130 gp130 NNS cord-317820-od9l7p1r 78 31 , , , cord-317820-od9l7p1r 78 32 IL6ST IL6ST NNP cord-317820-od9l7p1r 78 33 ) ) -RRB- cord-317820-od9l7p1r 79 1 and and CC cord-317820-od9l7p1r 79 2 it -PRON- PRP cord-317820-od9l7p1r 79 3 activates activate VBZ cord-317820-od9l7p1r 79 4 the the DT cord-317820-od9l7p1r 79 5 special special JJ cord-317820-od9l7p1r 79 6 signal signal NN cord-317820-od9l7p1r 79 7 pathway pathway NN cord-317820-od9l7p1r 79 8 named name VBN cord-317820-od9l7p1r 79 9 as as IN cord-317820-od9l7p1r 79 10 IL6 IL6 NNP cord-317820-od9l7p1r 79 11 / / SYM cord-317820-od9l7p1r 79 12 JAK JAK NNP cord-317820-od9l7p1r 79 13 / / SYM cord-317820-od9l7p1r 79 14 STAT3 STAT3 NNP cord-317820-od9l7p1r 79 15 . . . cord-317820-od9l7p1r 80 1 Thusly thusly RB cord-317820-od9l7p1r 80 2 , , , cord-317820-od9l7p1r 80 3 increased increase VBN cord-317820-od9l7p1r 80 4 levels level NNS cord-317820-od9l7p1r 80 5 of of IN cord-317820-od9l7p1r 80 6 IL6 il6 NN cord-317820-od9l7p1r 80 7 trigger trigger NN cord-317820-od9l7p1r 80 8 activation activation NN cord-317820-od9l7p1r 80 9 of of IN cord-317820-od9l7p1r 80 10 inflammation inflammation NN cord-317820-od9l7p1r 80 11 - - HYPH cord-317820-od9l7p1r 80 12 related relate VBN cord-317820-od9l7p1r 80 13 downstream downstream JJ cord-317820-od9l7p1r 80 14 targets target NNS cord-317820-od9l7p1r 80 15 [ [ -LRB- cord-317820-od9l7p1r 80 16 58 58 CD cord-317820-od9l7p1r 80 17 ] ] -RRB- cord-317820-od9l7p1r 80 18 . . . cord-317820-od9l7p1r 81 1 Upregulated upregulated JJ cord-317820-od9l7p1r 81 2 gene gene NN cord-317820-od9l7p1r 81 3 expression expression NN cord-317820-od9l7p1r 81 4 level level NN cord-317820-od9l7p1r 81 5 or or CC cord-317820-od9l7p1r 81 6 elevated elevated JJ cord-317820-od9l7p1r 81 7 serum serum NN cord-317820-od9l7p1r 81 8 concentration concentration NN cord-317820-od9l7p1r 81 9 of of IN cord-317820-od9l7p1r 81 10 cytokines cytokine NNS cord-317820-od9l7p1r 82 1 , , , cord-317820-od9l7p1r 82 2 especially especially RB cord-317820-od9l7p1r 82 3 IL6 IL6 NNP cord-317820-od9l7p1r 82 4 is be VBZ cord-317820-od9l7p1r 82 5 showed show VBN cord-317820-od9l7p1r 82 6 that that IN cord-317820-od9l7p1r 82 7 it -PRON- PRP cord-317820-od9l7p1r 82 8 is be VBZ cord-317820-od9l7p1r 82 9 one one CD cord-317820-od9l7p1r 82 10 of of IN cord-317820-od9l7p1r 82 11 the the DT cord-317820-od9l7p1r 82 12 pivotal pivotal JJ cord-317820-od9l7p1r 82 13 cytokines cytokine NNS cord-317820-od9l7p1r 82 14 in in IN cord-317820-od9l7p1r 82 15 influenza influenza NN cord-317820-od9l7p1r 82 16 , , , cord-317820-od9l7p1r 82 17 vaccinia vaccinia NN cord-317820-od9l7p1r 82 18 , , , cord-317820-od9l7p1r 82 19 hepatitis hepatitis NN cord-317820-od9l7p1r 82 20 B B NNP cord-317820-od9l7p1r 82 21 and and CC cord-317820-od9l7p1r 82 22 C C NNP cord-317820-od9l7p1r 82 23 , , , cord-317820-od9l7p1r 82 24 Crimean Crimean NNP cord-317820-od9l7p1r 82 25 - - HYPH cord-317820-od9l7p1r 82 26 Congo Congo NNP cord-317820-od9l7p1r 82 27 hemorrhagic hemorrhagic JJ cord-317820-od9l7p1r 82 28 fever fever NN cord-317820-od9l7p1r 82 29 , , , cord-317820-od9l7p1r 82 30 and and CC cord-317820-od9l7p1r 82 31 human human JJ cord-317820-od9l7p1r 82 32 immunodeficiency immunodeficiency NN cord-317820-od9l7p1r 82 33 virus virus NN cord-317820-od9l7p1r 82 34 infections infection NNS cord-317820-od9l7p1r 82 35 in in IN cord-317820-od9l7p1r 82 36 humans human NNS cord-317820-od9l7p1r 82 37 and and CC cord-317820-od9l7p1r 82 38 rabies rabie NNS cord-317820-od9l7p1r 82 39 , , , cord-317820-od9l7p1r 82 40 swine swine NN cord-317820-od9l7p1r 82 41 fever fever NN cord-317820-od9l7p1r 82 42 virus virus NN cord-317820-od9l7p1r 82 43 infections infection NNS cord-317820-od9l7p1r 82 44 in in IN cord-317820-od9l7p1r 82 45 different different JJ cord-317820-od9l7p1r 82 46 mammalian mammalian JJ cord-317820-od9l7p1r 82 47 species specie NNS cord-317820-od9l7p1r 82 48 [ [ -LRB- cord-317820-od9l7p1r 82 49 60 60 CD cord-317820-od9l7p1r 82 50 ] ] -RRB- cord-317820-od9l7p1r 82 51 . . . cord-317820-od9l7p1r 83 1 Similarly similarly RB cord-317820-od9l7p1r 83 2 , , , cord-317820-od9l7p1r 83 3 IL6 IL6 NNP cord-317820-od9l7p1r 83 4 is be VBZ cord-317820-od9l7p1r 83 5 the the DT cord-317820-od9l7p1r 83 6 most most RBS cord-317820-od9l7p1r 83 7 remarkable remarkable JJ cord-317820-od9l7p1r 83 8 cytokine cytokine NN cord-317820-od9l7p1r 83 9 in in IN cord-317820-od9l7p1r 83 10 COVID-19-induced covid-19-induced JJ cord-317820-od9l7p1r 83 11 cytokine cytokine NN cord-317820-od9l7p1r 83 12 storm storm NN cord-317820-od9l7p1r 83 13 syndrome syndrome NN cord-317820-od9l7p1r 83 14 . . . cord-317820-od9l7p1r 84 1 Elevated elevated JJ cord-317820-od9l7p1r 84 2 serum serum NN cord-317820-od9l7p1r 84 3 levels level NNS cord-317820-od9l7p1r 84 4 of of IN cord-317820-od9l7p1r 84 5 IL6 IL6 NNS cord-317820-od9l7p1r 84 6 are be VBP cord-317820-od9l7p1r 84 7 emphasized emphasize VBN cord-317820-od9l7p1r 84 8 as as IN cord-317820-od9l7p1r 84 9 the the DT cord-317820-od9l7p1r 84 10 main main JJ cord-317820-od9l7p1r 84 11 indicator indicator NN cord-317820-od9l7p1r 84 12 of of IN cord-317820-od9l7p1r 84 13 cytokine cytokine NN cord-317820-od9l7p1r 84 14 storm storm NN cord-317820-od9l7p1r 84 15 and and CC cord-317820-od9l7p1r 84 16 poor poor JJ cord-317820-od9l7p1r 84 17 prognosis prognosis NN cord-317820-od9l7p1r 84 18 in in IN cord-317820-od9l7p1r 84 19 SARS SARS NNP cord-317820-od9l7p1r 84 20 - - HYPH cord-317820-od9l7p1r 84 21 CoV-2 CoV-2 NNP cord-317820-od9l7p1r 84 22 infection infection NN cord-317820-od9l7p1r 84 23 . . . cord-317820-od9l7p1r 85 1 The the DT cord-317820-od9l7p1r 85 2 local local JJ cord-317820-od9l7p1r 85 3 inflammatory inflammatory JJ cord-317820-od9l7p1r 85 4 response response NN cord-317820-od9l7p1r 85 5 also also RB cord-317820-od9l7p1r 85 6 spreads spread VBZ cord-317820-od9l7p1r 85 7 to to IN cord-317820-od9l7p1r 85 8 the the DT cord-317820-od9l7p1r 85 9 body body NN cord-317820-od9l7p1r 85 10 and and CC cord-317820-od9l7p1r 85 11 causes cause VBZ cord-317820-od9l7p1r 85 12 cytokine cytokine NN cord-317820-od9l7p1r 85 13 release release NN cord-317820-od9l7p1r 85 14 syndrome syndrome NN cord-317820-od9l7p1r 85 15 or or CC cord-317820-od9l7p1r 85 16 cytokine cytokine NN cord-317820-od9l7p1r 85 17 storm storm NN cord-317820-od9l7p1r 85 18 that that WDT cord-317820-od9l7p1r 85 19 causes cause VBZ cord-317820-od9l7p1r 85 20 acute acute JJ cord-317820-od9l7p1r 85 21 respiratory respiratory JJ cord-317820-od9l7p1r 85 22 distress distress NN cord-317820-od9l7p1r 85 23 syndrome syndrome NN cord-317820-od9l7p1r 85 24 and and CC cord-317820-od9l7p1r 85 25 organ organ NN cord-317820-od9l7p1r 85 26 damages damage NNS cord-317820-od9l7p1r 85 27 . . . cord-317820-od9l7p1r 86 1 Different different JJ cord-317820-od9l7p1r 86 2 approaches approach NNS cord-317820-od9l7p1r 86 3 which which WDT cord-317820-od9l7p1r 86 4 include include VBP cord-317820-od9l7p1r 86 5 inhibition inhibition NN cord-317820-od9l7p1r 86 6 of of IN cord-317820-od9l7p1r 86 7 the the DT cord-317820-od9l7p1r 86 8 elevated elevated JJ cord-317820-od9l7p1r 86 9 molecules molecule NNS cord-317820-od9l7p1r 86 10 or or CC cord-317820-od9l7p1r 86 11 hyper hyper RB cord-317820-od9l7p1r 86 12 - - JJ cord-317820-od9l7p1r 86 13 activated activate VBN cord-317820-od9l7p1r 86 14 pathways pathway NNS cord-317820-od9l7p1r 86 15 and and CC cord-317820-od9l7p1r 86 16 purification purification NN cord-317820-od9l7p1r 86 17 of of IN cord-317820-od9l7p1r 86 18 the the DT cord-317820-od9l7p1r 86 19 blood blood NN cord-317820-od9l7p1r 86 20 are be VBP cord-317820-od9l7p1r 86 21 suggested suggest VBN cord-317820-od9l7p1r 86 22 to to TO cord-317820-od9l7p1r 86 23 overcome overcome VB cord-317820-od9l7p1r 86 24 this this DT cord-317820-od9l7p1r 86 25 hyper hyper JJ cord-317820-od9l7p1r 86 26 - - JJ cord-317820-od9l7p1r 86 27 inflammation inflammation JJ cord-317820-od9l7p1r 86 28 situation situation NN cord-317820-od9l7p1r 86 29 during during IN cord-317820-od9l7p1r 86 30 COVID-19 covid-19 JJ cord-317820-od9l7p1r 86 31 treatment treatment NN cord-317820-od9l7p1r 86 32 [ [ -LRB- cord-317820-od9l7p1r 86 33 28 28 CD cord-317820-od9l7p1r 86 34 ] ] -RRB- cord-317820-od9l7p1r 86 35 . . . cord-317820-od9l7p1r 87 1 The the DT cord-317820-od9l7p1r 87 2 usage usage NN cord-317820-od9l7p1r 87 3 of of IN cord-317820-od9l7p1r 87 4 the the DT cord-317820-od9l7p1r 87 5 JAK JAK NNP cord-317820-od9l7p1r 87 6 / / SYM cord-317820-od9l7p1r 87 7 STAT STAT NNP cord-317820-od9l7p1r 87 8 pathway pathway NN cord-317820-od9l7p1r 87 9 inhibitors inhibitor NNS cord-317820-od9l7p1r 87 10 and and CC cord-317820-od9l7p1r 87 11 specific specific JJ cord-317820-od9l7p1r 87 12 anti anti JJ cord-317820-od9l7p1r 87 13 - - JJ cord-317820-od9l7p1r 87 14 cytokine cytokine JJ cord-317820-od9l7p1r 87 15 molecules molecule NNS cord-317820-od9l7p1r 87 16 , , , cord-317820-od9l7p1r 87 17 especially especially RB cord-317820-od9l7p1r 87 18 anti anti JJ cord-317820-od9l7p1r 87 19 - - NNP cord-317820-od9l7p1r 87 20 IL6 IL6 NNP cord-317820-od9l7p1r 87 21 , , , cord-317820-od9l7p1r 87 22 are be VBP cord-317820-od9l7p1r 87 23 the the DT cord-317820-od9l7p1r 87 24 most most RBS cord-317820-od9l7p1r 87 25 remarkable remarkable JJ cord-317820-od9l7p1r 87 26 approaches approach NNS cord-317820-od9l7p1r 87 27 to to TO cord-317820-od9l7p1r 87 28 fight fight VB cord-317820-od9l7p1r 87 29 this this DT cord-317820-od9l7p1r 87 30 situation situation NN cord-317820-od9l7p1r 87 31 . . . cord-317820-od9l7p1r 88 1 The the DT cord-317820-od9l7p1r 88 2 first first JJ cord-317820-od9l7p1r 88 3 approved approve VBN cord-317820-od9l7p1r 88 4 JAK JAK NNP cord-317820-od9l7p1r 88 5 inhibitor inhibitor NN cord-317820-od9l7p1r 88 6 is be VBZ cord-317820-od9l7p1r 88 7 ruxolitinib ruxolitinib JJ cord-317820-od9l7p1r 88 8 , , , cord-317820-od9l7p1r 88 9 and and CC cord-317820-od9l7p1r 88 10 it -PRON- PRP cord-317820-od9l7p1r 88 11 followed follow VBD cord-317820-od9l7p1r 88 12 by by IN cord-317820-od9l7p1r 88 13 the the DT cord-317820-od9l7p1r 88 14 other other JJ cord-317820-od9l7p1r 88 15 JAK JAK NNP cord-317820-od9l7p1r 88 16 inhibitors inhibitor NNS cord-317820-od9l7p1r 88 17 that that WDT cord-317820-od9l7p1r 88 18 are be VBP cord-317820-od9l7p1r 88 19 baricitinib baricitinib NNP cord-317820-od9l7p1r 88 20 , , , cord-317820-od9l7p1r 88 21 upadacitinib upadacitinib NNP cord-317820-od9l7p1r 88 22 , , , cord-317820-od9l7p1r 88 23 tofacitinib tofacitinib NNP cord-317820-od9l7p1r 88 24 , , , cord-317820-od9l7p1r 88 25 peficitinib peficitinib NNP cord-317820-od9l7p1r 88 26 , , , cord-317820-od9l7p1r 88 27 and and CC cord-317820-od9l7p1r 88 28 fedratinib fedratinib NN cord-317820-od9l7p1r 88 29 [ [ -LRB- cord-317820-od9l7p1r 88 30 61 61 CD cord-317820-od9l7p1r 88 31 ] ] -RRB- cord-317820-od9l7p1r 88 32 [ [ -LRB- cord-317820-od9l7p1r 88 33 62 62 CD cord-317820-od9l7p1r 88 34 ] ] -RRB- cord-317820-od9l7p1r 88 35 [ [ -LRB- cord-317820-od9l7p1r 88 36 63 63 CD cord-317820-od9l7p1r 88 37 ] ] -RRB- cord-317820-od9l7p1r 88 38 . . . cord-317820-od9l7p1r 89 1 There there EX cord-317820-od9l7p1r 89 2 are be VBP cord-317820-od9l7p1r 89 3 clinical clinical JJ cord-317820-od9l7p1r 89 4 studies study NNS cord-317820-od9l7p1r 89 5 including include VBG cord-317820-od9l7p1r 89 6 baricitinib baricitinib NNP cord-317820-od9l7p1r 89 7 , , , cord-317820-od9l7p1r 89 8 tofacitinib tofacitinib NNP cord-317820-od9l7p1r 89 9 , , , cord-317820-od9l7p1r 89 10 and and CC cord-317820-od9l7p1r 89 11 ruxolitinib ruxolitinib JJ cord-317820-od9l7p1r 89 12 JAK JAK NNP cord-317820-od9l7p1r 89 13 inhibitors inhibitor NNS cord-317820-od9l7p1r 89 14 against against IN cord-317820-od9l7p1r 89 15 cytokine cytokine NN cord-317820-od9l7p1r 89 16 storm storm NN cord-317820-od9l7p1r 89 17 caused cause VBN cord-317820-od9l7p1r 89 18 by by IN cord-317820-od9l7p1r 89 19 COVID-19 COVID-19 NNP cord-317820-od9l7p1r 89 20 . . . cord-317820-od9l7p1r 90 1 Among among IN cord-317820-od9l7p1r 90 2 these these DT cord-317820-od9l7p1r 90 3 , , , cord-317820-od9l7p1r 90 4 baricitinib baricitinib NNP cord-317820-od9l7p1r 90 5 ( ( -LRB- cord-317820-od9l7p1r 90 6 LY3009104 ly3009104 NN cord-317820-od9l7p1r 90 7 , , , cord-317820-od9l7p1r 90 8 INCB028050 INCB028050 NNP cord-317820-od9l7p1r 90 9 , , , cord-317820-od9l7p1r 90 10 Olumiant Olumiant NNP cord-317820-od9l7p1r 90 11 , , , cord-317820-od9l7p1r 90 12 Eli Eli NNP cord-317820-od9l7p1r 90 13 Lilly Lilly NNP cord-317820-od9l7p1r 90 14 ) ) -RRB- cord-317820-od9l7p1r 90 15 is be VBZ cord-317820-od9l7p1r 90 16 a a DT cord-317820-od9l7p1r 90 17 second second JJ cord-317820-od9l7p1r 90 18 JAK1 JAK1 NNP cord-317820-od9l7p1r 90 19 and and CC cord-317820-od9l7p1r 90 20 JAK2 JAK2 NNP cord-317820-od9l7p1r 90 21 inhibitor inhibitor NN cord-317820-od9l7p1r 90 22 is be VBZ cord-317820-od9l7p1r 90 23 approved approve VBN cord-317820-od9l7p1r 90 24 in in IN cord-317820-od9l7p1r 90 25 2018 2018 CD cord-317820-od9l7p1r 90 26 for for IN cord-317820-od9l7p1r 90 27 treatment treatment NN cord-317820-od9l7p1r 90 28 of of IN cord-317820-od9l7p1r 90 29 rheumatoid rheumatoid JJ cord-317820-od9l7p1r 90 30 arthritis arthritis NN cord-317820-od9l7p1r 90 31 . . . cord-317820-od9l7p1r 91 1 Besides besides IN cord-317820-od9l7p1r 91 2 the the DT cord-317820-od9l7p1r 91 3 antiinflammatory antiinflammatory JJ cord-317820-od9l7p1r 91 4 effects effect NNS cord-317820-od9l7p1r 91 5 , , , cord-317820-od9l7p1r 91 6 it -PRON- PRP cord-317820-od9l7p1r 91 7 also also RB cord-317820-od9l7p1r 91 8 inhibits inhibit VBZ cord-317820-od9l7p1r 91 9 endocytosis endocytosis NN cord-317820-od9l7p1r 91 10 of of IN cord-317820-od9l7p1r 91 11 the the DT cord-317820-od9l7p1r 91 12 virus virus NN cord-317820-od9l7p1r 91 13 , , , cord-317820-od9l7p1r 91 14 it -PRON- PRP cord-317820-od9l7p1r 91 15 is be VBZ cord-317820-od9l7p1r 91 16 suggested suggest VBN cord-317820-od9l7p1r 91 17 for for IN cord-317820-od9l7p1r 91 18 COVID-19 covid-19 JJ cord-317820-od9l7p1r 91 19 treatments treatment NNS cord-317820-od9l7p1r 91 20 [ [ -LRB- cord-317820-od9l7p1r 91 21 64 64 CD cord-317820-od9l7p1r 91 22 ] ] -RRB- cord-317820-od9l7p1r 91 23 . . . cord-317820-od9l7p1r 92 1 Although although IN cord-317820-od9l7p1r 92 2 clinical clinical JJ cord-317820-od9l7p1r 92 3 studies study NNS cord-317820-od9l7p1r 92 4 have have VBP cord-317820-od9l7p1r 92 5 started start VBN cord-317820-od9l7p1r 92 6 , , , cord-317820-od9l7p1r 92 7 it -PRON- PRP cord-317820-od9l7p1r 92 8 has have VBZ cord-317820-od9l7p1r 92 9 also also RB cord-317820-od9l7p1r 92 10 been be VBN cord-317820-od9l7p1r 92 11 suggested suggest VBN cord-317820-od9l7p1r 92 12 that that IN cord-317820-od9l7p1r 92 13 this this DT cord-317820-od9l7p1r 92 14 molecule molecule NN cord-317820-od9l7p1r 92 15 may may MD cord-317820-od9l7p1r 92 16 make make VB cord-317820-od9l7p1r 92 17 patients patient NNS cord-317820-od9l7p1r 92 18 vulnerable vulnerable JJ cord-317820-od9l7p1r 92 19 to to IN cord-317820-od9l7p1r 92 20 co co NN cord-317820-od9l7p1r 92 21 - - NN cord-317820-od9l7p1r 92 22 infection infection NN cord-317820-od9l7p1r 92 23 , , , cord-317820-od9l7p1r 92 24 virus virus NN cord-317820-od9l7p1r 92 25 reactivation reactivation NN cord-317820-od9l7p1r 92 26 , , , cord-317820-od9l7p1r 92 27 lymphocytopenia lymphocytopenia NNP cord-317820-od9l7p1r 92 28 , , , cord-317820-od9l7p1r 92 29 and and CC cord-317820-od9l7p1r 92 30 neutropenia neutropenia NN cord-317820-od9l7p1r 92 31 , , , cord-317820-od9l7p1r 92 32 thusly thusly RB cord-317820-od9l7p1r 92 33 it -PRON- PRP cord-317820-od9l7p1r 92 34 is be VBZ cord-317820-od9l7p1r 92 35 suggested suggest VBN cord-317820-od9l7p1r 92 36 that that IN cord-317820-od9l7p1r 92 37 it -PRON- PRP cord-317820-od9l7p1r 92 38 may may MD cord-317820-od9l7p1r 92 39 not not RB cord-317820-od9l7p1r 92 40 be be VB cord-317820-od9l7p1r 92 41 an an DT cord-317820-od9l7p1r 92 42 ideal ideal JJ cord-317820-od9l7p1r 92 43 choice choice NN cord-317820-od9l7p1r 92 44 [ [ -LRB- cord-317820-od9l7p1r 92 45 65 65 CD cord-317820-od9l7p1r 92 46 ] ] -RRB- cord-317820-od9l7p1r 92 47 . . . cord-317820-od9l7p1r 93 1 A a DT cord-317820-od9l7p1r 93 2 similar similar JJ cord-317820-od9l7p1r 93 3 situation situation NN cord-317820-od9l7p1r 93 4 is be VBZ cord-317820-od9l7p1r 93 5 encountered encounter VBN cord-317820-od9l7p1r 93 6 about about IN cord-317820-od9l7p1r 93 7 interleukin interleukin NN cord-317820-od9l7p1r 93 8 inhibitors inhibitor NNS cord-317820-od9l7p1r 93 9 also also RB cord-317820-od9l7p1r 93 10 . . . cord-317820-od9l7p1r 94 1 It -PRON- PRP cord-317820-od9l7p1r 94 2 is be VBZ cord-317820-od9l7p1r 94 3 reported report VBN cord-317820-od9l7p1r 94 4 that that IN cord-317820-od9l7p1r 94 5 tocilizumab tocilizumab NN cord-317820-od9l7p1r 94 6 which which WDT cord-317820-od9l7p1r 94 7 is be VBZ cord-317820-od9l7p1r 94 8 an an DT cord-317820-od9l7p1r 94 9 approved approve VBN cord-317820-od9l7p1r 94 10 IL6 IL6 NNP cord-317820-od9l7p1r 94 11 receptor receptor NN cord-317820-od9l7p1r 94 12 antagonist antagonist NN cord-317820-od9l7p1r 94 13 , , , cord-317820-od9l7p1r 94 14 treatment treatment NN cord-317820-od9l7p1r 94 15 reduced reduce VBN cord-317820-od9l7p1r 94 16 cytokine cytokine NN cord-317820-od9l7p1r 94 17 release release NN cord-317820-od9l7p1r 94 18 syndrome syndrome NN cord-317820-od9l7p1r 94 19 symptoms symptom NNS cord-317820-od9l7p1r 94 20 in in IN cord-317820-od9l7p1r 94 21 severe severe JJ cord-317820-od9l7p1r 94 22 patients patient NNS cord-317820-od9l7p1r 94 23 COVID-19 covid-19 VBP cord-317820-od9l7p1r 94 24 [ [ -LRB- cord-317820-od9l7p1r 94 25 66 66 CD cord-317820-od9l7p1r 94 26 ] ] -RRB- cord-317820-od9l7p1r 94 27 . . . cord-317820-od9l7p1r 95 1 On on IN cord-317820-od9l7p1r 95 2 the the DT cord-317820-od9l7p1r 95 3 other other JJ cord-317820-od9l7p1r 95 4 hand hand NN cord-317820-od9l7p1r 95 5 , , , cord-317820-od9l7p1r 95 6 it -PRON- PRP cord-317820-od9l7p1r 95 7 is be VBZ cord-317820-od9l7p1r 95 8 also also RB cord-317820-od9l7p1r 95 9 suggested suggest VBN cord-317820-od9l7p1r 95 10 that that IN cord-317820-od9l7p1r 95 11 J J NNP cord-317820-od9l7p1r 95 12 o o NN cord-317820-od9l7p1r 95 13 u u NN cord-317820-od9l7p1r 95 14 r r NN cord-317820-od9l7p1r 95 15 n n NN cord-317820-od9l7p1r 95 16 a a DT cord-317820-od9l7p1r 95 17 l l NN cord-317820-od9l7p1r 95 18 P p NN cord-317820-od9l7p1r 95 19 r r NN cord-317820-od9l7p1r 95 20 e e NN cord-317820-od9l7p1r 95 21 -p -p NN cord-317820-od9l7p1r 96 1 r r NN cord-317820-od9l7p1r 96 2 o o NN cord-317820-od9l7p1r 96 3 o o NN cord-317820-od9l7p1r 96 4 f f NN cord-317820-od9l7p1r 96 5 the the DT cord-317820-od9l7p1r 96 6 tocilizumab tocilizumab NNP cord-317820-od9l7p1r 96 7 application application NN cord-317820-od9l7p1r 96 8 may may MD cord-317820-od9l7p1r 96 9 cause cause VB cord-317820-od9l7p1r 96 10 poor poor JJ cord-317820-od9l7p1r 96 11 prognosis prognosis NN cord-317820-od9l7p1r 96 12 and and CC cord-317820-od9l7p1r 96 13 death death NN cord-317820-od9l7p1r 96 14 by by IN cord-317820-od9l7p1r 96 15 adding add VBG cord-317820-od9l7p1r 96 16 immunosuppression immunosuppression NN cord-317820-od9l7p1r 96 17 to to IN cord-317820-od9l7p1r 96 18 bad bad JJ cord-317820-od9l7p1r 96 19 clinical clinical JJ cord-317820-od9l7p1r 96 20 profiles profile NNS cord-317820-od9l7p1r 96 21 [ [ -LRB- cord-317820-od9l7p1r 96 22 30 30 CD cord-317820-od9l7p1r 96 23 ] ] -RRB- cord-317820-od9l7p1r 96 24 . . . cord-317820-od9l7p1r 97 1 effective effective JJ cord-317820-od9l7p1r 97 2 treatment treatment NN cord-317820-od9l7p1r 97 3 by by IN cord-317820-od9l7p1r 97 4 overcoming overcome VBG cord-317820-od9l7p1r 97 5 the the DT cord-317820-od9l7p1r 97 6 increase increase NN cord-317820-od9l7p1r 97 7 in in IN cord-317820-od9l7p1r 97 8 cytokine cytokine NN cord-317820-od9l7p1r 97 9 levels level NNS cord-317820-od9l7p1r 97 10 , , , cord-317820-od9l7p1r 97 11 which which WDT cord-317820-od9l7p1r 97 12 is be VBZ cord-317820-od9l7p1r 97 13 the the DT cord-317820-od9l7p1r 97 14 main main JJ cord-317820-od9l7p1r 97 15 factor factor NN cord-317820-od9l7p1r 97 16 in in IN cord-317820-od9l7p1r 97 17 these these DT cord-317820-od9l7p1r 97 18 diseases disease NNS cord-317820-od9l7p1r 97 19 . . . cord-317820-od9l7p1r 98 1 Therefore therefore RB cord-317820-od9l7p1r 98 2 , , , cord-317820-od9l7p1r 98 3 ruxolitinib ruxolitinib NNP cord-317820-od9l7p1r 98 4 has have VBZ cord-317820-od9l7p1r 98 5 started start VBN cord-317820-od9l7p1r 98 6 to to TO cord-317820-od9l7p1r 98 7 take take VB cord-317820-od9l7p1r 98 8 its -PRON- PRP$ cord-317820-od9l7p1r 98 9 place place NN cord-317820-od9l7p1r 98 10 as as IN cord-317820-od9l7p1r 98 11 a a DT cord-317820-od9l7p1r 98 12 current current JJ cord-317820-od9l7p1r 98 13 subject subject NN cord-317820-od9l7p1r 98 14 in in IN cord-317820-od9l7p1r 98 15 the the DT cord-317820-od9l7p1r 98 16 treatment treatment NN cord-317820-od9l7p1r 98 17 of of IN cord-317820-od9l7p1r 98 18 autoimmune autoimmune JJ cord-317820-od9l7p1r 98 19 diseases disease NNS cord-317820-od9l7p1r 98 20 such such JJ cord-317820-od9l7p1r 98 21 as as IN cord-317820-od9l7p1r 98 22 rheumatoid rheumatoid JJ cord-317820-od9l7p1r 98 23 arthritis arthritis NN cord-317820-od9l7p1r 98 24 , , , cord-317820-od9l7p1r 98 25 psoriasis psoriasis NN cord-317820-od9l7p1r 98 26 , , , cord-317820-od9l7p1r 98 27 and and CC cord-317820-od9l7p1r 98 28 lupus lupus NN cord-317820-od9l7p1r 98 29 erythematosus erythematosus NN cord-317820-od9l7p1r 98 30 and and CC cord-317820-od9l7p1r 98 31 other other JJ cord-317820-od9l7p1r 98 32 inflammatory inflammatory JJ cord-317820-od9l7p1r 98 33 diseases disease NNS cord-317820-od9l7p1r 98 34 such such JJ cord-317820-od9l7p1r 98 35 as as IN cord-317820-od9l7p1r 98 36 allergy allergy NN cord-317820-od9l7p1r 98 37 and and CC cord-317820-od9l7p1r 98 38 asthma asthma NN cord-317820-od9l7p1r 98 39 [ [ -LRB- cord-317820-od9l7p1r 98 40 67 67 CD cord-317820-od9l7p1r 98 41 ] ] -RRB- cord-317820-od9l7p1r 98 42 . . . cord-317820-od9l7p1r 99 1 Ruxolitinib Ruxolitinib NNP cord-317820-od9l7p1r 99 2 also also RB cord-317820-od9l7p1r 99 3 inhibits inhibit VBZ cord-317820-od9l7p1r 99 4 IL6 il6 NN cord-317820-od9l7p1r 99 5 / / SYM cord-317820-od9l7p1r 99 6 JAK JAK NNP cord-317820-od9l7p1r 99 7 / / SYM cord-317820-od9l7p1r 99 8 STAT3 STAT3 NNP cord-317820-od9l7p1r 99 9 pathway pathway NN cord-317820-od9l7p1r 99 10 , , , cord-317820-od9l7p1r 99 11 reduces reduce VBZ cord-317820-od9l7p1r 99 12 expression expression NN cord-317820-od9l7p1r 99 13 levels level NNS cord-317820-od9l7p1r 99 14 , , , cord-317820-od9l7p1r 99 15 and and CC cord-317820-od9l7p1r 99 16 circulating circulate VBG cord-317820-od9l7p1r 99 17 IL6 il6 NN cord-317820-od9l7p1r 99 18 levels level NNS cord-317820-od9l7p1r 99 19 [ [ -LRB- cord-317820-od9l7p1r 99 20 68 68 CD cord-317820-od9l7p1r 99 21 , , , cord-317820-od9l7p1r 99 22 69 69 CD cord-317820-od9l7p1r 99 23 ] ] -RRB- cord-317820-od9l7p1r 99 24 . . . cord-317820-od9l7p1r 100 1 There there EX cord-317820-od9l7p1r 100 2 are be VBP cord-317820-od9l7p1r 100 3 studies study NNS cord-317820-od9l7p1r 100 4 involving involve VBG cord-317820-od9l7p1r 100 5 the the DT cord-317820-od9l7p1r 100 6 potential potential NN cord-317820-od9l7p1r 100 7 of of IN cord-317820-od9l7p1r 100 8 using use VBG cord-317820-od9l7p1r 100 9 ruxolitinib ruxolitinib NNP cord-317820-od9l7p1r 100 10 in in IN cord-317820-od9l7p1r 100 11 different different JJ cord-317820-od9l7p1r 100 12 viral viral JJ cord-317820-od9l7p1r 100 13 infections infection NNS cord-317820-od9l7p1r 100 14 due due JJ cord-317820-od9l7p1r 100 15 to to IN cord-317820-od9l7p1r 100 16 its -PRON- PRP$ cord-317820-od9l7p1r 100 17 immune immune JJ cord-317820-od9l7p1r 100 18 suppressor suppressor NN cord-317820-od9l7p1r 100 19 and and CC cord-317820-od9l7p1r 100 20 anti anti JJ cord-317820-od9l7p1r 100 21 - - JJ cord-317820-od9l7p1r 100 22 viral viral JJ cord-317820-od9l7p1r 100 23 properties property NNS cord-317820-od9l7p1r 100 24 . . . cord-317820-od9l7p1r 101 1 Ruxolitinib Ruxolitinib NNP cord-317820-od9l7p1r 101 2 is be VBZ cord-317820-od9l7p1r 101 3 used use VBN cord-317820-od9l7p1r 101 4 against against IN cord-317820-od9l7p1r 101 5 both both DT cord-317820-od9l7p1r 101 6 acute acute JJ cord-317820-od9l7p1r 101 7 and and CC cord-317820-od9l7p1r 101 8 chronic chronic JJ cord-317820-od9l7p1r 101 9 graft graft NN cord-317820-od9l7p1r 101 10 versus versus IN cord-317820-od9l7p1r 101 11 host host NN cord-317820-od9l7p1r 101 12 disease disease NN cord-317820-od9l7p1r 101 13 which which WDT cord-317820-od9l7p1r 101 14 is be VBZ cord-317820-od9l7p1r 101 15 originated originate VBN cord-317820-od9l7p1r 101 16 from from IN cord-317820-od9l7p1r 101 17 allogeneic allogeneic IN cord-317820-od9l7p1r 101 18 hematopoietic hematopoietic JJ cord-317820-od9l7p1r 101 19 stem stem NN cord-317820-od9l7p1r 101 20 cell cell NN cord-317820-od9l7p1r 101 21 transplantation transplantation NN cord-317820-od9l7p1r 101 22 with with IN cord-317820-od9l7p1r 101 23 its -PRON- PRP$ cord-317820-od9l7p1r 101 24 immunosuppression immunosuppression NN cord-317820-od9l7p1r 101 25 features feature VBZ cord-317820-od9l7p1r 101 26 including include VBG cord-317820-od9l7p1r 101 27 both both DT cord-317820-od9l7p1r 101 28 JAK2 JAK2 NNP cord-317820-od9l7p1r 101 29 and and CC cord-317820-od9l7p1r 101 30 IL6 il6 NN cord-317820-od9l7p1r 101 31 inhibitions inhibition NNS cord-317820-od9l7p1r 101 32 [ [ -LRB- cord-317820-od9l7p1r 101 33 70 70 CD cord-317820-od9l7p1r 101 34 ] ] -RRB- cord-317820-od9l7p1r 101 35 . . . cord-317820-od9l7p1r 102 1 Hemophagocytic hemophagocytic JJ cord-317820-od9l7p1r 102 2 lymphohistiocytosis lymphohistiocytosis NN cord-317820-od9l7p1r 102 3 is be VBZ cord-317820-od9l7p1r 102 4 a a DT cord-317820-od9l7p1r 102 5 rare rare JJ cord-317820-od9l7p1r 102 6 secondary secondary JJ cord-317820-od9l7p1r 102 7 disease disease NN cord-317820-od9l7p1r 102 8 triggered trigger VBN cord-317820-od9l7p1r 102 9 by by IN cord-317820-od9l7p1r 102 10 viral viral JJ cord-317820-od9l7p1r 102 11 infections infection NNS cord-317820-od9l7p1r 102 12 or or CC cord-317820-od9l7p1r 102 13 autoimmune autoimmune JJ cord-317820-od9l7p1r 102 14 diseases disease NNS cord-317820-od9l7p1r 102 15 in in IN cord-317820-od9l7p1r 102 16 which which WDT cord-317820-od9l7p1r 102 17 elevated elevated JJ cord-317820-od9l7p1r 102 18 activation activation NN cord-317820-od9l7p1r 102 19 of of IN cord-317820-od9l7p1r 102 20 the the DT cord-317820-od9l7p1r 102 21 immune immune JJ cord-317820-od9l7p1r 102 22 response response NN cord-317820-od9l7p1r 102 23 may may MD cord-317820-od9l7p1r 102 24 cause cause VB cord-317820-od9l7p1r 102 25 mortal mortal JJ cord-317820-od9l7p1r 102 26 complications complication NNS cord-317820-od9l7p1r 102 27 . . . cord-317820-od9l7p1r 103 1 It -PRON- PRP cord-317820-od9l7p1r 103 2 is be VBZ cord-317820-od9l7p1r 103 3 reported report VBN cord-317820-od9l7p1r 103 4 that that IN cord-317820-od9l7p1r 103 5 the the DT cord-317820-od9l7p1r 103 6 usage usage NN cord-317820-od9l7p1r 103 7 of of IN cord-317820-od9l7p1r 103 8 ruxolitinib ruxolitinib NNP cord-317820-od9l7p1r 103 9 suppresses suppress VBZ cord-317820-od9l7p1r 103 10 cytokine cytokine NN cord-317820-od9l7p1r 103 11 levels level NNS cord-317820-od9l7p1r 103 12 and and CC cord-317820-od9l7p1r 103 13 JAK JAK NNP cord-317820-od9l7p1r 103 14 / / SYM cord-317820-od9l7p1r 103 15 STAT stat NN cord-317820-od9l7p1r 103 16 pathway pathway NN cord-317820-od9l7p1r 103 17 in in IN cord-317820-od9l7p1r 103 18 Epstein Epstein NNP cord-317820-od9l7p1r 103 19 - - HYPH cord-317820-od9l7p1r 103 20 Barr Barr NNP cord-317820-od9l7p1r 103 21 Virus Virus NNP cord-317820-od9l7p1r 103 22 ( ( -LRB- cord-317820-od9l7p1r 103 23 EBV EBV NNP cord-317820-od9l7p1r 103 24 ) ) -RRB- cord-317820-od9l7p1r 104 1 -associated -associate VBN cord-317820-od9l7p1r 105 1 hemophagocytic hemophagocytic NNP cord-317820-od9l7p1r 105 2 lymphohistiocytosis lymphohistiocytosis NNP cord-317820-od9l7p1r 105 3 [ [ -LRB- cord-317820-od9l7p1r 105 4 71 71 CD cord-317820-od9l7p1r 105 5 ] ] -RRB- cord-317820-od9l7p1r 105 6 . . . cord-317820-od9l7p1r 106 1 Anti anti JJ cord-317820-od9l7p1r 106 2 - - JJ cord-317820-od9l7p1r 106 3 viral viral JJ cord-317820-od9l7p1r 106 4 property property NN cord-317820-od9l7p1r 106 5 of of IN cord-317820-od9l7p1r 106 6 ruxolitinib ruxolitinib NNP cord-317820-od9l7p1r 106 7 is be VBZ cord-317820-od9l7p1r 106 8 associated associate VBN cord-317820-od9l7p1r 106 9 with with IN cord-317820-od9l7p1r 106 10 Human Human NNP cord-317820-od9l7p1r 106 11 Immunodeficiency Immunodeficiency NNP cord-317820-od9l7p1r 106 12 Virus Virus NNP cord-317820-od9l7p1r 106 13 ( ( -LRB- cord-317820-od9l7p1r 106 14 HIV HIV NNP cord-317820-od9l7p1r 106 15 ) ) -RRB- cord-317820-od9l7p1r 106 16 and and CC cord-317820-od9l7p1r 106 17 EBV EBV NNP cord-317820-od9l7p1r 106 18 infections infection NNS cord-317820-od9l7p1r 106 19 which which WDT cord-317820-od9l7p1r 106 20 influence influence VBP cord-317820-od9l7p1r 106 21 primarily primarily RB cord-317820-od9l7p1r 106 22 immune immune JJ cord-317820-od9l7p1r 106 23 cells cell NNS cord-317820-od9l7p1r 106 24 . . . cord-317820-od9l7p1r 107 1 inflammation inflammation NN cord-317820-od9l7p1r 108 1 that that IN cord-317820-od9l7p1r 108 2 making make VBG cord-317820-od9l7p1r 108 3 conditions condition NNS cord-317820-od9l7p1r 108 4 more more RBR cord-317820-od9l7p1r 108 5 favorable favorable JJ cord-317820-od9l7p1r 108 6 for for IN cord-317820-od9l7p1r 108 7 systemic systemic JJ cord-317820-od9l7p1r 108 8 infection infection NN cord-317820-od9l7p1r 108 9 . . . cord-317820-od9l7p1r 109 1 It -PRON- PRP cord-317820-od9l7p1r 109 2 is be VBZ cord-317820-od9l7p1r 109 3 showed show VBN cord-317820-od9l7p1r 109 4 that that IN cord-317820-od9l7p1r 109 5 ruxolitinib ruxolitinib NNP cord-317820-od9l7p1r 109 6 has have VBZ cord-317820-od9l7p1r 109 7 toxicity toxicity NN cord-317820-od9l7p1r 109 8 on on IN cord-317820-od9l7p1r 109 9 HIV-1 HIV-1 NNP cord-317820-od9l7p1r 109 10 , , , cord-317820-od9l7p1r 109 11 and and CC cord-317820-od9l7p1r 109 12 HIV-2 HIV-2 NNP cord-317820-od9l7p1r 109 13 infected infect VBD cord-317820-od9l7p1r 109 14 human human JJ cord-317820-od9l7p1r 109 15 peripheral peripheral JJ cord-317820-od9l7p1r 109 16 blood blood NN cord-317820-od9l7p1r 109 17 mononuclear mononuclear NN cord-317820-od9l7p1r 109 18 cells cell NNS cord-317820-od9l7p1r 109 19 , , , cord-317820-od9l7p1r 109 20 J J NNP cord-317820-od9l7p1r 109 21 o o NNP cord-317820-od9l7p1r 110 1 u u NNP cord-317820-od9l7p1r 110 2 r r NNP cord-317820-od9l7p1r 110 3 n n NN cord-317820-od9l7p1r 110 4 a a DT cord-317820-od9l7p1r 110 5 l l NN cord-317820-od9l7p1r 110 6 P p NN cord-317820-od9l7p1r 110 7 r r NN cord-317820-od9l7p1r 110 8 e e NN cord-317820-od9l7p1r 110 9 -p -p NN cord-317820-od9l7p1r 111 1 r r NNP cord-317820-od9l7p1r 111 2 o o NN cord-317820-od9l7p1r 111 3 o o NN cord-317820-od9l7p1r 111 4 f f NN cord-317820-od9l7p1r 111 5 inhibits inhibit VBZ cord-317820-od9l7p1r 111 6 HIV-1 HIV-1 NNP cord-317820-od9l7p1r 111 7 replication replication NN cord-317820-od9l7p1r 111 8 in in IN cord-317820-od9l7p1r 111 9 lymphocytes lymphocyte NNS cord-317820-od9l7p1r 111 10 and and CC cord-317820-od9l7p1r 111 11 macrophages macrophage NNS cord-317820-od9l7p1r 111 12 and and CC cord-317820-od9l7p1r 111 13 suppresses suppress VBZ cord-317820-od9l7p1r 111 14 reactivation reactivation NN cord-317820-od9l7p1r 111 15 of of IN cord-317820-od9l7p1r 111 16 the the DT cord-317820-od9l7p1r 111 17 viruses virus NNS cord-317820-od9l7p1r 111 18 [ [ -LRB- cord-317820-od9l7p1r 111 19 72 72 CD cord-317820-od9l7p1r 111 20 ] ] -RRB- cord-317820-od9l7p1r 111 21 . . . cord-317820-od9l7p1r 112 1 It -PRON- PRP cord-317820-od9l7p1r 112 2 is be VBZ cord-317820-od9l7p1r 112 3 suggested suggest VBN cord-317820-od9l7p1r 112 4 that that IN cord-317820-od9l7p1r 112 5 these these DT cord-317820-od9l7p1r 112 6 effects effect NNS cord-317820-od9l7p1r 112 7 of of IN cord-317820-od9l7p1r 112 8 ruxolitinib ruxolitinib NNP cord-317820-od9l7p1r 112 9 originate originate VBP cord-317820-od9l7p1r 112 10 from from IN cord-317820-od9l7p1r 112 11 JAK JAK NNP cord-317820-od9l7p1r 112 12 / / SYM cord-317820-od9l7p1r 112 13 STAT stat NN cord-317820-od9l7p1r 112 14 pathway pathway NN cord-317820-od9l7p1r 112 15 inhibition inhibition NN cord-317820-od9l7p1r 112 16 which which WDT cord-317820-od9l7p1r 112 17 involved involve VBN cord-317820-od9l7p1r 112 18 in in IN cord-317820-od9l7p1r 112 19 both both DT cord-317820-od9l7p1r 112 20 viral viral JJ cord-317820-od9l7p1r 112 21 proliferation proliferation NN cord-317820-od9l7p1r 112 22 and and CC cord-317820-od9l7p1r 112 23 reduction reduction NN cord-317820-od9l7p1r 112 24 of of IN cord-317820-od9l7p1r 112 25 inflammatory inflammatory JJ cord-317820-od9l7p1r 112 26 downstream downstream JJ cord-317820-od9l7p1r 112 27 molecules molecule NNS cord-317820-od9l7p1r 112 28 like like IN cord-317820-od9l7p1r 112 29 _SP cord-317820-od9l7p1r 112 30 IL1β IL1β NNP cord-317820-od9l7p1r 112 31 , , , cord-317820-od9l7p1r 112 32 IL2 IL2 NNP cord-317820-od9l7p1r 112 33 , , , cord-317820-od9l7p1r 112 34 IL5 IL5 NNP cord-317820-od9l7p1r 112 35 , , , cord-317820-od9l7p1r 112 36 IL6 IL6 NNP cord-317820-od9l7p1r 112 37 , , , cord-317820-od9l7p1r 112 38 IL7 IL7 NNS cord-317820-od9l7p1r 112 39 , , , cord-317820-od9l7p1r 112 40 IL13 IL13 NNP cord-317820-od9l7p1r 112 41 , , , cord-317820-od9l7p1r 112 42 IL15 IL15 NNP cord-317820-od9l7p1r 112 43 , , , cord-317820-od9l7p1r 112 44 and and CC cord-317820-od9l7p1r 112 45 IFNG IFNG NNP cord-317820-od9l7p1r 112 46 [ [ -LRB- cord-317820-od9l7p1r 112 47 73 73 CD cord-317820-od9l7p1r 112 48 ] ] -RRB- cord-317820-od9l7p1r 112 49 [ [ -LRB- cord-317820-od9l7p1r 112 50 74 74 CD cord-317820-od9l7p1r 112 51 ] ] -RRB- cord-317820-od9l7p1r 113 1 [ [ -LRB- cord-317820-od9l7p1r 113 2 75 75 CD cord-317820-od9l7p1r 113 3 ] ] -RRB- cord-317820-od9l7p1r 113 4 . . . cord-317820-od9l7p1r 114 1 In in IN cord-317820-od9l7p1r 114 2 the the DT cord-317820-od9l7p1r 114 3 same same JJ cord-317820-od9l7p1r 114 4 manner manner NN cord-317820-od9l7p1r 114 5 , , , cord-317820-od9l7p1r 114 6 the the DT cord-317820-od9l7p1r 114 7 anti anti JJ cord-317820-od9l7p1r 114 8 - - JJ cord-317820-od9l7p1r 114 9 viral viral JJ cord-317820-od9l7p1r 114 10 potential potential NN cord-317820-od9l7p1r 114 11 of of IN cord-317820-od9l7p1r 114 12 ruxolitinib ruxolitinib NNP cord-317820-od9l7p1r 114 13 is be VBZ cord-317820-od9l7p1r 114 14 also also RB cord-317820-od9l7p1r 114 15 indicated indicate VBN cord-317820-od9l7p1r 114 16 in in IN cord-317820-od9l7p1r 114 17 EBV EBV NNP cord-317820-od9l7p1r 114 18 infection infection NN cord-317820-od9l7p1r 114 19 . . . cord-317820-od9l7p1r 115 1 Ruxolitinib Ruxolitinib NNP cord-317820-od9l7p1r 115 2 inhibits inhibit VBZ cord-317820-od9l7p1r 115 3 EBV EBV NNP cord-317820-od9l7p1r 115 4 - - HYPH cord-317820-od9l7p1r 115 5 infected infect VBN cord-317820-od9l7p1r 115 6 PBMC PBMC NNP cord-317820-od9l7p1r 115 7 proliferation proliferation NN cord-317820-od9l7p1r 115 8 and and CC cord-317820-od9l7p1r 115 9 reduces reduce VBZ cord-317820-od9l7p1r 115 10 elevated elevate VBN cord-317820-od9l7p1r 115 11 inflammatory inflammatory JJ cord-317820-od9l7p1r 115 12 cytokines cytokine NNS cord-317820-od9l7p1r 115 13 by by IN cord-317820-od9l7p1r 115 14 inhibiting inhibit VBG cord-317820-od9l7p1r 115 15 activation activation NN cord-317820-od9l7p1r 115 16 of of IN cord-317820-od9l7p1r 115 17 especially especially RB cord-317820-od9l7p1r 115 18 STAT3 STAT3 NNP cord-317820-od9l7p1r 115 19 [ [ -LRB- cord-317820-od9l7p1r 115 20 76 76 CD cord-317820-od9l7p1r 115 21 , , , cord-317820-od9l7p1r 115 22 77 77 CD cord-317820-od9l7p1r 115 23 ] ] -RRB- cord-317820-od9l7p1r 115 24 . . . cord-317820-od9l7p1r 116 1 Since since IN cord-317820-od9l7p1r 116 2 the the DT cord-317820-od9l7p1r 116 3 JAK JAK NNP cord-317820-od9l7p1r 116 4 / / SYM cord-317820-od9l7p1r 116 5 STAT stat NN cord-317820-od9l7p1r 116 6 pathway pathway NN cord-317820-od9l7p1r 116 7 is be VBZ cord-317820-od9l7p1r 116 8 the the DT cord-317820-od9l7p1r 116 9 primary primary JJ cord-317820-od9l7p1r 116 10 signal signal NN cord-317820-od9l7p1r 116 11 pathway pathway NN cord-317820-od9l7p1r 116 12 that that WDT cord-317820-od9l7p1r 116 13 controls control VBZ cord-317820-od9l7p1r 116 14 the the DT cord-317820-od9l7p1r 116 15 proliferation proliferation NN cord-317820-od9l7p1r 116 16 of of IN cord-317820-od9l7p1r 116 17 immune immune JJ cord-317820-od9l7p1r 116 18 cells cell NNS cord-317820-od9l7p1r 116 19 , , , cord-317820-od9l7p1r 116 20 suppression suppression NN cord-317820-od9l7p1r 116 21 of of IN cord-317820-od9l7p1r 116 22 this this DT cord-317820-od9l7p1r 116 23 pathway pathway NN cord-317820-od9l7p1r 116 24 which which WDT cord-317820-od9l7p1r 116 25 causes cause VBZ cord-317820-od9l7p1r 116 26 a a DT cord-317820-od9l7p1r 116 27 reduction reduction NN cord-317820-od9l7p1r 116 28 in in IN cord-317820-od9l7p1r 116 29 the the DT cord-317820-od9l7p1r 116 30 immune immune JJ cord-317820-od9l7p1r 116 31 response response NN cord-317820-od9l7p1r 116 32 can can MD cord-317820-od9l7p1r 116 33 also also RB cord-317820-od9l7p1r 116 34 result result VB cord-317820-od9l7p1r 116 35 in in IN cord-317820-od9l7p1r 116 36 the the DT cord-317820-od9l7p1r 116 37 emergence emergence NN cord-317820-od9l7p1r 116 38 of of IN cord-317820-od9l7p1r 116 39 opportunistic opportunistic JJ cord-317820-od9l7p1r 116 40 infections infection NNS cord-317820-od9l7p1r 116 41 . . . cord-317820-od9l7p1r 117 1 The the DT cord-317820-od9l7p1r 117 2 development development NN cord-317820-od9l7p1r 117 3 of of IN cord-317820-od9l7p1r 117 4 Polyomavirus Polyomavirus NNP cord-317820-od9l7p1r 117 5 ( ( -LRB- cord-317820-od9l7p1r 117 6 JC JC NNP cord-317820-od9l7p1r 117 7 - - HYPH cord-317820-od9l7p1r 117 8 Virus Virus NNP cord-317820-od9l7p1r 117 9 and and CC cord-317820-od9l7p1r 117 10 BK BK NNP cord-317820-od9l7p1r 117 11 - - HYPH cord-317820-od9l7p1r 117 12 Virus Virus NNP cord-317820-od9l7p1r 117 13 ) ) -RRB- cord-317820-od9l7p1r 117 14 related relate VBN cord-317820-od9l7p1r 117 15 fatal fatal JJ cord-317820-od9l7p1r 117 16 encephalopathy encephalopathy NN cord-317820-od9l7p1r 117 17 and and CC cord-317820-od9l7p1r 117 18 meningitis meningitis NN cord-317820-od9l7p1r 117 19 has have VBZ cord-317820-od9l7p1r 117 20 been be VBN cord-317820-od9l7p1r 117 21 reported report VBN cord-317820-od9l7p1r 117 22 during during IN cord-317820-od9l7p1r 117 23 ruxolitinib ruxolitinib JJ cord-317820-od9l7p1r 117 24 treatment treatment NN cord-317820-od9l7p1r 117 25 [ [ -LRB- cord-317820-od9l7p1r 117 26 78 78 CD cord-317820-od9l7p1r 117 27 , , , cord-317820-od9l7p1r 117 28 79 79 CD cord-317820-od9l7p1r 117 29 ] ] -RRB- cord-317820-od9l7p1r 117 30 . . . cord-317820-od9l7p1r 118 1 Because because IN cord-317820-od9l7p1r 118 2 the the DT cord-317820-od9l7p1r 118 3 JAK JAK NNP cord-317820-od9l7p1r 118 4 / / SYM cord-317820-od9l7p1r 118 5 STAT stat NN cord-317820-od9l7p1r 118 6 pathway pathway NN cord-317820-od9l7p1r 118 7 inhibits inhibit VBZ cord-317820-od9l7p1r 118 8 Zika Zika NNP cord-317820-od9l7p1r 118 9 Virus Virus NNP cord-317820-od9l7p1r 118 10 ( ( -LRB- cord-317820-od9l7p1r 118 11 ZIKV ZIKV NNP cord-317820-od9l7p1r 118 12 ) ) -RRB- cord-317820-od9l7p1r 118 13 and and CC cord-317820-od9l7p1r 118 14 Hepatitis Hepatitis NNP cord-317820-od9l7p1r 118 15 C C NNP cord-317820-od9l7p1r 118 16 Virus Virus NNP cord-317820-od9l7p1r 118 17 ( ( -LRB- cord-317820-od9l7p1r 118 18 HCV HCV NNP cord-317820-od9l7p1r 118 19 ) ) -RRB- cord-317820-od9l7p1r 118 20 , , , cord-317820-od9l7p1r 118 21 are be VBP cord-317820-od9l7p1r 118 22 members member NNS cord-317820-od9l7p1r 118 23 of of IN cord-317820-od9l7p1r 118 24 the the DT cord-317820-od9l7p1r 118 25 Flaviviridae Flaviviridae NNP cord-317820-od9l7p1r 118 26 family family NN cord-317820-od9l7p1r 118 27 , , , cord-317820-od9l7p1r 118 28 it -PRON- PRP cord-317820-od9l7p1r 118 29 is be VBZ cord-317820-od9l7p1r 118 30 suggested suggest VBN cord-317820-od9l7p1r 118 31 that that IN cord-317820-od9l7p1r 118 32 ruxolitinib ruxolitinib NNP cord-317820-od9l7p1r 118 33 may may MD cord-317820-od9l7p1r 118 34 increase increase VB cord-317820-od9l7p1r 118 35 viral viral JJ cord-317820-od9l7p1r 118 36 replication replication NN cord-317820-od9l7p1r 118 37 [ [ -LRB- cord-317820-od9l7p1r 118 38 80 80 CD cord-317820-od9l7p1r 118 39 , , , cord-317820-od9l7p1r 118 40 81 81 CD cord-317820-od9l7p1r 118 41 ] ] -RRB- cord-317820-od9l7p1r 118 42 . . . cord-317820-od9l7p1r 119 1 It -PRON- PRP cord-317820-od9l7p1r 119 2 is be VBZ cord-317820-od9l7p1r 119 3 also also RB cord-317820-od9l7p1r 119 4 reported report VBN cord-317820-od9l7p1r 119 5 that that IN cord-317820-od9l7p1r 119 6 Hepadnaviridae Hepadnaviridae NNP cord-317820-od9l7p1r 119 7 family family NN cord-317820-od9l7p1r 119 8 member member NN cord-317820-od9l7p1r 119 9 Hepatitis Hepatitis NNP cord-317820-od9l7p1r 119 10 B B NNP cord-317820-od9l7p1r 119 11 Virus Virus NNP cord-317820-od9l7p1r 119 12 ( ( -LRB- cord-317820-od9l7p1r 119 13 HBV HBV NNP cord-317820-od9l7p1r 119 14 ) ) -RRB- cord-317820-od9l7p1r 119 15 is be VBZ cord-317820-od9l7p1r 119 16 reactivated reactivate VBN cord-317820-od9l7p1r 119 17 due due IN cord-317820-od9l7p1r 119 18 to to IN cord-317820-od9l7p1r 119 19 ruxolitinib ruxolitinib JJ cord-317820-od9l7p1r 119 20 treatment treatment NN cord-317820-od9l7p1r 119 21 [ [ -LRB- cord-317820-od9l7p1r 119 22 82 82 CD cord-317820-od9l7p1r 119 23 ] ] -RRB- cord-317820-od9l7p1r 119 24 . . . cord-317820-od9l7p1r 120 1 Infections infection NNS cord-317820-od9l7p1r 120 2 of of IN cord-317820-od9l7p1r 120 3 different different JJ cord-317820-od9l7p1r 120 4 Herpesvirus Herpesvirus NNP cord-317820-od9l7p1r 120 5 family family NN cord-317820-od9l7p1r 120 6 members member NNS cord-317820-od9l7p1r 120 7 which which WDT cord-317820-od9l7p1r 120 8 include include VBP cord-317820-od9l7p1r 120 9 Varicella varicella NN cord-317820-od9l7p1r 120 10 - - HYPH cord-317820-od9l7p1r 120 11 Zoster Zoster NNP cord-317820-od9l7p1r 120 12 Virus virus NN cord-317820-od9l7p1r 120 13 ( ( -LRB- cord-317820-od9l7p1r 120 14 VZV VZV NNP cord-317820-od9l7p1r 120 15 ) ) -RRB- cord-317820-od9l7p1r 120 16 , , , cord-317820-od9l7p1r 120 17 EBV EBV NNP cord-317820-od9l7p1r 120 18 , , , cord-317820-od9l7p1r 120 19 and and CC cord-317820-od9l7p1r 120 20 Cytomegalovirus Cytomegalovirus NNP cord-317820-od9l7p1r 120 21 ( ( -LRB- cord-317820-od9l7p1r 120 22 CMV CMV NNP cord-317820-od9l7p1r 120 23 ) ) -RRB- cord-317820-od9l7p1r 120 24 , , , cord-317820-od9l7p1r 120 25 have have VBP cord-317820-od9l7p1r 120 26 also also RB cord-317820-od9l7p1r 120 27 been be VBN cord-317820-od9l7p1r 120 28 reported report VBN cord-317820-od9l7p1r 120 29 . . . cord-317820-od9l7p1r 121 1 Development development NN cord-317820-od9l7p1r 121 2 of of IN cord-317820-od9l7p1r 121 3 gastric gastric JJ cord-317820-od9l7p1r 121 4 ulcer ulcer NN cord-317820-od9l7p1r 121 5 and and CC cord-317820-od9l7p1r 121 6 meningoencephalitis meningoencephalitis NN cord-317820-od9l7p1r 121 7 due due IN cord-317820-od9l7p1r 121 8 to to IN cord-317820-od9l7p1r 121 9 EBV EBV NNP cord-317820-od9l7p1r 121 10 and and CC cord-317820-od9l7p1r 121 11 VZV VZV NNP cord-317820-od9l7p1r 121 12 infections infection NNS cord-317820-od9l7p1r 121 13 has have VBZ cord-317820-od9l7p1r 121 14 been be VBN cord-317820-od9l7p1r 121 15 reported report VBN cord-317820-od9l7p1r 121 16 in in IN cord-317820-od9l7p1r 121 17 patients patient NNS cord-317820-od9l7p1r 121 18 with with IN cord-317820-od9l7p1r 121 19 myelofibrosis myelofibrosis NNP cord-317820-od9l7p1r 121 20 and and CC cord-317820-od9l7p1r 121 21 polycythemia polycythemia NN cord-317820-od9l7p1r 121 22 vera vera NNP cord-317820-od9l7p1r 121 23 treated treat VBN cord-317820-od9l7p1r 121 24 with with IN cord-317820-od9l7p1r 121 25 ruxolitinib ruxolitinib NNP cord-317820-od9l7p1r 121 26 , , , cord-317820-od9l7p1r 121 27 respectively respectively RB cord-317820-od9l7p1r 121 28 [ [ -LRB- cord-317820-od9l7p1r 121 29 83 83 CD cord-317820-od9l7p1r 121 30 , , , cord-317820-od9l7p1r 121 31 84 84 CD cord-317820-od9l7p1r 121 32 ] ] -RRB- cord-317820-od9l7p1r 121 33 . . . cord-317820-od9l7p1r 122 1 Ruxolitinib Ruxolitinib NNP cord-317820-od9l7p1r 122 2 has have VBZ cord-317820-od9l7p1r 122 3 also also RB cord-317820-od9l7p1r 122 4 been be VBN cord-317820-od9l7p1r 122 5 associated associate VBN cord-317820-od9l7p1r 122 6 with with IN cord-317820-od9l7p1r 122 7 reactivation reactivation NN cord-317820-od9l7p1r 122 8 of of IN cord-317820-od9l7p1r 122 9 CMV CMV NNP cord-317820-od9l7p1r 122 10 , , , cord-317820-od9l7p1r 122 11 VZV VZV NNP cord-317820-od9l7p1r 122 12 , , , cord-317820-od9l7p1r 122 13 and and CC cord-317820-od9l7p1r 122 14 EBV EBV NNP cord-317820-od9l7p1r 122 15 during during IN cord-317820-od9l7p1r 122 16 myelofibrosis myelofibrosis NNP cord-317820-od9l7p1r 122 17 , , , cord-317820-od9l7p1r 122 18 graft graft NN cord-317820-od9l7p1r 122 19 versus versus IN cord-317820-od9l7p1r 122 20 host host NN cord-317820-od9l7p1r 122 21 disease disease NN cord-317820-od9l7p1r 122 22 , , , cord-317820-od9l7p1r 122 23 and and CC cord-317820-od9l7p1r 122 24 myelodysplastic myelodysplastic JJ cord-317820-od9l7p1r 122 25 syndrome syndrome NN cord-317820-od9l7p1r 122 26 treatments treatment NNS cord-317820-od9l7p1r 122 27 [ [ -LRB- cord-317820-od9l7p1r 122 28 85 85 CD cord-317820-od9l7p1r 122 29 ] ] -RRB- cord-317820-od9l7p1r 122 30 [ [ -LRB- cord-317820-od9l7p1r 122 31 86 86 CD cord-317820-od9l7p1r 122 32 ] ] -RRB- cord-317820-od9l7p1r 122 33 [ [ -LRB- cord-317820-od9l7p1r 122 34 87 87 CD cord-317820-od9l7p1r 122 35 ] ] -RRB- cord-317820-od9l7p1r 122 36 [ [ -LRB- cord-317820-od9l7p1r 122 37 88 88 CD cord-317820-od9l7p1r 122 38 ] ] -RRB- cord-317820-od9l7p1r 122 39 . . . cord-317820-od9l7p1r 123 1 Reactivation reactivation NN cord-317820-od9l7p1r 123 2 causes cause VBZ cord-317820-od9l7p1r 123 3 secondary secondary JJ cord-317820-od9l7p1r 123 4 diseases disease NNS cord-317820-od9l7p1r 123 5 that that WDT cord-317820-od9l7p1r 123 6 include include VBP cord-317820-od9l7p1r 123 7 lymphoproliferative lymphoproliferative JJ cord-317820-od9l7p1r 123 8 disorders disorder NNS cord-317820-od9l7p1r 123 9 [ [ -LRB- cord-317820-od9l7p1r 123 10 89 89 CD cord-317820-od9l7p1r 123 11 ] ] -RRB- cord-317820-od9l7p1r 123 12 . . . cord-317820-od9l7p1r 124 1 While while IN cord-317820-od9l7p1r 124 2 determining determine VBG cord-317820-od9l7p1r 124 3 ruxolitinib ruxolitinib NNP cord-317820-od9l7p1r 124 4 's 's POS cord-317820-od9l7p1r 124 5 potential potential JJ cord-317820-od9l7p1r 124 6 efficacy efficacy NN cord-317820-od9l7p1r 124 7 against against IN cord-317820-od9l7p1r 124 8 SARS SARS NNP cord-317820-od9l7p1r 124 9 - - HYPH cord-317820-od9l7p1r 124 10 CoV-2 CoV-2 NNP cord-317820-od9l7p1r 124 11 , , , cord-317820-od9l7p1r 124 12 positive positive JJ cord-317820-od9l7p1r 124 13 and and CC cord-317820-od9l7p1r 124 14 negative negative JJ cord-317820-od9l7p1r 124 15 properties property NNS cord-317820-od9l7p1r 124 16 in in IN cord-317820-od9l7p1r 124 17 other other JJ cord-317820-od9l7p1r 124 18 viral viral JJ cord-317820-od9l7p1r 124 19 infections infection NNS cord-317820-od9l7p1r 124 20 constitute constitute VBP cord-317820-od9l7p1r 124 21 an an DT cord-317820-od9l7p1r 124 22 important important JJ cord-317820-od9l7p1r 124 23 parameter parameter NN cord-317820-od9l7p1r 124 24 , , , cord-317820-od9l7p1r 124 25 but but CC cord-317820-od9l7p1r 124 26 it -PRON- PRP cord-317820-od9l7p1r 124 27 can can MD cord-317820-od9l7p1r 124 28 not not RB cord-317820-od9l7p1r 124 29 be be VB cord-317820-od9l7p1r 124 30 expected expect VBN cord-317820-od9l7p1r 124 31 to to TO cord-317820-od9l7p1r 124 32 be be VB cord-317820-od9l7p1r 124 33 determinant determinant JJ cord-317820-od9l7p1r 124 34 alone alone RB cord-317820-od9l7p1r 124 35 . . . cord-317820-od9l7p1r 125 1 Since since IN cord-317820-od9l7p1r 125 2 ruxolitinib ruxolitinib NNP cord-317820-od9l7p1r 125 3 is be VBZ cord-317820-od9l7p1r 125 4 a a DT cord-317820-od9l7p1r 125 5 well well RB cord-317820-od9l7p1r 125 6 - - HYPH cord-317820-od9l7p1r 125 7 tolerated tolerate VBN cord-317820-od9l7p1r 125 8 drug drug NN cord-317820-od9l7p1r 125 9 and and CC cord-317820-od9l7p1r 125 10 used use VBN cord-317820-od9l7p1r 125 11 for for IN cord-317820-od9l7p1r 125 12 the the DT cord-317820-od9l7p1r 125 13 treatment treatment NN cord-317820-od9l7p1r 125 14 for for IN cord-317820-od9l7p1r 125 15 the the DT cord-317820-od9l7p1r 125 16 elderly elderly JJ cord-317820-od9l7p1r 125 17 population population NN cord-317820-od9l7p1r 125 18 at at IN cord-317820-od9l7p1r 125 19 present present NN cord-317820-od9l7p1r 125 20 , , , cord-317820-od9l7p1r 125 21 it -PRON- PRP cord-317820-od9l7p1r 125 22 is be VBZ cord-317820-od9l7p1r 125 23 suggested suggest VBN cord-317820-od9l7p1r 125 24 as as IN cord-317820-od9l7p1r 125 25 a a DT cord-317820-od9l7p1r 125 26 powerful powerful JJ cord-317820-od9l7p1r 125 27 candidate candidate NN cord-317820-od9l7p1r 125 28 to to TO cord-317820-od9l7p1r 125 29 overcome overcome VB cord-317820-od9l7p1r 125 30 the the DT cord-317820-od9l7p1r 125 31 hyperimmune hyperimmune NNP cord-317820-od9l7p1r 125 32 syndrome syndrome NN cord-317820-od9l7p1r 125 33 that that WDT cord-317820-od9l7p1r 125 34 raises raise VBZ cord-317820-od9l7p1r 125 35 the the DT cord-317820-od9l7p1r 125 36 mortality mortality NN cord-317820-od9l7p1r 125 37 numbers number NNS cord-317820-od9l7p1r 125 38 in in IN cord-317820-od9l7p1r 125 39 the the DT cord-317820-od9l7p1r 125 40 COVID-19 COVID-19 NNP cord-317820-od9l7p1r 125 41 [ [ -LRB- cord-317820-od9l7p1r 125 42 68 68 CD cord-317820-od9l7p1r 125 43 ] ] -RRB- cord-317820-od9l7p1r 125 44 . . . cord-317820-od9l7p1r 126 1 There there EX cord-317820-od9l7p1r 126 2 are be VBP cord-317820-od9l7p1r 126 3 currently currently RB cord-317820-od9l7p1r 126 4 ongoing ongoing JJ cord-317820-od9l7p1r 126 5 clinical clinical JJ cord-317820-od9l7p1r 126 6 trials trial NNS cord-317820-od9l7p1r 126 7 about about IN cord-317820-od9l7p1r 126 8 the the DT cord-317820-od9l7p1r 126 9 potential potential JJ cord-317820-od9l7p1r 126 10 efficacy efficacy NN cord-317820-od9l7p1r 126 11 of of IN cord-317820-od9l7p1r 126 12 ruxolitinib ruxolitinib NNP cord-317820-od9l7p1r 126 13 in in IN cord-317820-od9l7p1r 126 14 COVID-19 covid-19 JJ cord-317820-od9l7p1r 126 15 related related JJ cord-317820-od9l7p1r 126 16 symptoms symptom NNS cord-317820-od9l7p1r 126 17 ( ( -LRB- cord-317820-od9l7p1r 126 18 Table table NN cord-317820-od9l7p1r 126 19 1 1 CD cord-317820-od9l7p1r 126 20 ) ) -RRB- cord-317820-od9l7p1r 126 21 . . . cord-317820-od9l7p1r 127 1 To to TO cord-317820-od9l7p1r 127 2 determine determine VB cord-317820-od9l7p1r 127 3 the the DT cord-317820-od9l7p1r 127 4 potential potential JJ cord-317820-od9l7p1r 127 5 molecular molecular JJ cord-317820-od9l7p1r 127 6 efficacy efficacy NN cord-317820-od9l7p1r 127 7 of of IN cord-317820-od9l7p1r 127 8 ruxolitinib ruxolitinib NNP cord-317820-od9l7p1r 127 9 on on IN cord-317820-od9l7p1r 127 10 genetic genetic JJ cord-317820-od9l7p1r 127 11 alterations alteration NNS cord-317820-od9l7p1r 127 12 determined determine VBN cord-317820-od9l7p1r 127 13 in in IN cord-317820-od9l7p1r 127 14 various various JJ cord-317820-od9l7p1r 127 15 tissues tissue NNS cord-317820-od9l7p1r 127 16 and and CC cord-317820-od9l7p1r 127 17 blood blood NN cord-317820-od9l7p1r 127 18 levels level NNS cord-317820-od9l7p1r 127 19 of of IN cord-317820-od9l7p1r 127 20 COVID-19 covid-19 JJ cord-317820-od9l7p1r 127 21 patients patient NNS cord-317820-od9l7p1r 127 22 , , , cord-317820-od9l7p1r 127 23 JAK1 JAK1 NNP cord-317820-od9l7p1r 127 24 and and CC cord-317820-od9l7p1r 127 25 JAK2 JAK2 NNP cord-317820-od9l7p1r 127 26 by by IN cord-317820-od9l7p1r 127 27 using use VBG cord-317820-od9l7p1r 127 28 The the DT cord-317820-od9l7p1r 127 29 STRING string NN cord-317820-od9l7p1r 127 30 Database Database NNP cord-317820-od9l7p1r 127 31 Version Version NNP cord-317820-od9l7p1r 127 32 11 11 CD cord-317820-od9l7p1r 127 33 . . . cord-317820-od9l7p1r 128 1 Molecular molecular JJ cord-317820-od9l7p1r 128 2 pathways pathway NNS cord-317820-od9l7p1r 128 3 that that WDT cord-317820-od9l7p1r 128 4 include include VBP cord-317820-od9l7p1r 128 5 altered alter VBN cord-317820-od9l7p1r 128 6 genes gene NNS cord-317820-od9l7p1r 128 7 were be VBD cord-317820-od9l7p1r 128 8 determined determine VBN cord-317820-od9l7p1r 128 9 by by IN cord-317820-od9l7p1r 128 10 the the DT cord-317820-od9l7p1r 128 11 KEGG KEGG NNP cord-317820-od9l7p1r 128 12 Pathway Pathway NNP cord-317820-od9l7p1r 128 13 Database Database NNP cord-317820-od9l7p1r 128 14 ( ( -LRB- cord-317820-od9l7p1r 128 15 Figure Figure NNP cord-317820-od9l7p1r 128 16 4 4 CD cord-317820-od9l7p1r 128 17 ) ) -RRB- cord-317820-od9l7p1r 128 18 . . . cord-317820-od9l7p1r 129 1 Ruxolitinib Ruxolitinib NNP cord-317820-od9l7p1r 129 2 reduces reduce VBZ cord-317820-od9l7p1r 129 3 the the DT cord-317820-od9l7p1r 129 4 expression expression NN cord-317820-od9l7p1r 129 5 of of IN cord-317820-od9l7p1r 129 6 inflammatory inflammatory JJ cord-317820-od9l7p1r 129 7 biomarkers biomarker NNS cord-317820-od9l7p1r 129 8 , , , cord-317820-od9l7p1r 129 9 particularly particularly RB cord-317820-od9l7p1r 129 10 cytokine cytokine JJ cord-317820-od9l7p1r 129 11 storm storm NN cord-317820-od9l7p1r 129 12 syndrome syndrome NN cord-317820-od9l7p1r 129 13 , , , cord-317820-od9l7p1r 129 14 at at IN cord-317820-od9l7p1r 129 15 both both CC cord-317820-od9l7p1r 129 16 the the DT cord-317820-od9l7p1r 129 17 gene gene NN cord-317820-od9l7p1r 129 18 and and CC cord-317820-od9l7p1r 129 19 protein protein NN cord-317820-od9l7p1r 129 20 levels level NNS cord-317820-od9l7p1r 129 21 in in IN cord-317820-od9l7p1r 129 22 different different JJ cord-317820-od9l7p1r 129 23 cells cell NNS cord-317820-od9l7p1r 129 24 and and CC cord-317820-od9l7p1r 129 25 the the DT cord-317820-od9l7p1r 129 26 blood blood NN cord-317820-od9l7p1r 129 27 circulation circulation NN cord-317820-od9l7p1r 129 28 by by IN cord-317820-od9l7p1r 129 29 inhibiting inhibit VBG cord-317820-od9l7p1r 129 30 both both DT cord-317820-od9l7p1r 129 31 JAK1 JAK1 NNP cord-317820-od9l7p1r 129 32 and and CC cord-317820-od9l7p1r 129 33 JAK2 JAK2 NNP cord-317820-od9l7p1r 129 34 ( ( -LRB- cord-317820-od9l7p1r 129 35 Table table NN cord-317820-od9l7p1r 129 36 2 2 CD cord-317820-od9l7p1r 129 37 ) ) -RRB- cord-317820-od9l7p1r 129 38 . . . cord-317820-od9l7p1r 130 1 In in IN cord-317820-od9l7p1r 130 2 this this DT cord-317820-od9l7p1r 130 3 context context NN cord-317820-od9l7p1r 130 4 , , , cord-317820-od9l7p1r 130 5 it -PRON- PRP cord-317820-od9l7p1r 130 6 is be VBZ cord-317820-od9l7p1r 130 7 clear clear JJ cord-317820-od9l7p1r 130 8 that that IN cord-317820-od9l7p1r 130 9 ruxolitinib ruxolitinib NNP cord-317820-od9l7p1r 130 10 , , , cord-317820-od9l7p1r 130 11 which which WDT cord-317820-od9l7p1r 130 12 is be VBZ cord-317820-od9l7p1r 130 13 used use VBN cord-317820-od9l7p1r 130 14 especially especially RB cord-317820-od9l7p1r 130 15 in in IN cord-317820-od9l7p1r 130 16 older old JJR cord-317820-od9l7p1r 130 17 age age NN cord-317820-od9l7p1r 130 18 patients patient NNS cord-317820-od9l7p1r 130 19 , , , cord-317820-od9l7p1r 130 20 has have VBZ cord-317820-od9l7p1r 130 21 an an DT cord-317820-od9l7p1r 130 22 important important JJ cord-317820-od9l7p1r 130 23 potential potential NN cord-317820-od9l7p1r 130 24 in in IN cord-317820-od9l7p1r 130 25 overcoming overcome VBG cord-317820-od9l7p1r 130 26 complications complication NNS cord-317820-od9l7p1r 130 27 that that WDT cord-317820-od9l7p1r 130 28 are be VBP cord-317820-od9l7p1r 130 29 caused cause VBN cord-317820-od9l7p1r 130 30 by by IN cord-317820-od9l7p1r 130 31 over over IN cord-317820-od9l7p1r 130 32 activation activation NN cord-317820-od9l7p1r 130 33 of of IN cord-317820-od9l7p1r 130 34 the the DT cord-317820-od9l7p1r 130 35 immune immune JJ cord-317820-od9l7p1r 130 36 system system NN cord-317820-od9l7p1r 130 37 which which WDT cord-317820-od9l7p1r 130 38 is be VBZ cord-317820-od9l7p1r 130 39 triggered trigger VBN cord-317820-od9l7p1r 130 40 through through IN cord-317820-od9l7p1r 130 41 JAK JAK NNP cord-317820-od9l7p1r 130 42 / / SYM cord-317820-od9l7p1r 130 43 STAT stat NN cord-317820-od9l7p1r 130 44 signaling signal VBG cord-317820-od9l7p1r 130 45 pathway pathway NN cord-317820-od9l7p1r 130 46 . . . cord-317820-od9l7p1r 131 1 Since since IN cord-317820-od9l7p1r 131 2 the the DT cord-317820-od9l7p1r 131 3 JAK JAK NNP cord-317820-od9l7p1r 131 4 / / SYM cord-317820-od9l7p1r 131 5 STAT stat NN cord-317820-od9l7p1r 131 6 pathway pathway NN cord-317820-od9l7p1r 131 7 is be VBZ cord-317820-od9l7p1r 131 8 associated associate VBN cord-317820-od9l7p1r 131 9 with with IN cord-317820-od9l7p1r 131 10 the the DT cord-317820-od9l7p1r 131 11 regulation regulation NN cord-317820-od9l7p1r 131 12 of of IN cord-317820-od9l7p1r 131 13 multiple multiple JJ cord-317820-od9l7p1r 131 14 molecular molecular JJ cord-317820-od9l7p1r 131 15 pathways pathway NNS cord-317820-od9l7p1r 131 16 as as RB cord-317820-od9l7p1r 131 17 well well RB cord-317820-od9l7p1r 131 18 as as IN cord-317820-od9l7p1r 131 19 the the DT cord-317820-od9l7p1r 131 20 immune immune JJ cord-317820-od9l7p1r 131 21 system system NN cord-317820-od9l7p1r 131 22 , , , cord-317820-od9l7p1r 131 23 inhibition inhibition NN cord-317820-od9l7p1r 131 24 of of IN cord-317820-od9l7p1r 131 25 this this DT cord-317820-od9l7p1r 131 26 pathway pathway NN cord-317820-od9l7p1r 131 27 will will MD cord-317820-od9l7p1r 131 28 result result VB cord-317820-od9l7p1r 131 29 in in IN cord-317820-od9l7p1r 131 30 many many JJ cord-317820-od9l7p1r 131 31 cellular cellular JJ cord-317820-od9l7p1r 131 32 responses response NNS cord-317820-od9l7p1r 131 33 via via IN cord-317820-od9l7p1r 131 34 different different JJ cord-317820-od9l7p1r 131 35 cross cross NN cord-317820-od9l7p1r 131 36 talks talk NNS cord-317820-od9l7p1r 131 37 . . . cord-317820-od9l7p1r 132 1 Also also RB cord-317820-od9l7p1r 132 2 , , , cord-317820-od9l7p1r 132 3 both both CC cord-317820-od9l7p1r 132 4 JAK1 JAK1 NNP cord-317820-od9l7p1r 132 5 and and CC cord-317820-od9l7p1r 132 6 JAK2 JAK2 NNP cord-317820-od9l7p1r 132 7 interact interact VBP cord-317820-od9l7p1r 132 8 directly directly RB cord-317820-od9l7p1r 132 9 or or CC cord-317820-od9l7p1r 132 10 indirectly indirectly RB cord-317820-od9l7p1r 132 11 with with IN cord-317820-od9l7p1r 132 12 numerous numerous JJ cord-317820-od9l7p1r 132 13 proteins protein NNS cord-317820-od9l7p1r 132 14 . . . cord-317820-od9l7p1r 133 1 When when WRB cord-317820-od9l7p1r 133 2 all all DT cord-317820-od9l7p1r 133 3 of of IN cord-317820-od9l7p1r 133 4 the the DT cord-317820-od9l7p1r 133 5 findings finding NNS cord-317820-od9l7p1r 133 6 are be VBP cord-317820-od9l7p1r 133 7 considered consider VBN cord-317820-od9l7p1r 133 8 , , , cord-317820-od9l7p1r 133 9 ruxolitinib ruxolitinib NNP cord-317820-od9l7p1r 133 10 has have VBZ cord-317820-od9l7p1r 133 11 an an DT cord-317820-od9l7p1r 133 12 important important JJ cord-317820-od9l7p1r 133 13 potential potential NN cord-317820-od9l7p1r 133 14 in in IN cord-317820-od9l7p1r 133 15 COVID-19 covid-19 JJ cord-317820-od9l7p1r 133 16 infection infection NN cord-317820-od9l7p1r 133 17 . . . cord-317820-od9l7p1r 134 1 However however RB cord-317820-od9l7p1r 134 2 , , , cord-317820-od9l7p1r 134 3 adverse adverse JJ cord-317820-od9l7p1r 134 4 effects effect NNS cord-317820-od9l7p1r 134 5 such such JJ cord-317820-od9l7p1r 134 6 as as IN cord-317820-od9l7p1r 134 7 opportunistic opportunistic JJ cord-317820-od9l7p1r 134 8 infections infection NNS cord-317820-od9l7p1r 134 9 that that WDT cord-317820-od9l7p1r 134 10 may may MD cord-317820-od9l7p1r 134 11 occur occur VB cord-317820-od9l7p1r 134 12 as as IN cord-317820-od9l7p1r 134 13 a a DT cord-317820-od9l7p1r 134 14 result result NN cord-317820-od9l7p1r 134 15 of of IN cord-317820-od9l7p1r 134 16 suppression suppression NN cord-317820-od9l7p1r 134 17 of of IN cord-317820-od9l7p1r 134 18 the the DT cord-317820-od9l7p1r 134 19 immune immune JJ cord-317820-od9l7p1r 134 20 system system NN cord-317820-od9l7p1r 134 21 due due JJ cord-317820-od9l7p1r 134 22 to to IN cord-317820-od9l7p1r 134 23 JAK JAK NNP cord-317820-od9l7p1r 134 24 / / SYM cord-317820-od9l7p1r 134 25 STAT stat NN cord-317820-od9l7p1r 134 26 inhibition inhibition NN cord-317820-od9l7p1r 134 27 should should MD cord-317820-od9l7p1r 134 28 also also RB cord-317820-od9l7p1r 134 29 be be VB cord-317820-od9l7p1r 134 30 considered consider VBN cord-317820-od9l7p1r 134 31 in in IN cord-317820-od9l7p1r 134 32 this this DT cord-317820-od9l7p1r 134 33 process process NN cord-317820-od9l7p1r 134 34 . . . cord-317820-od9l7p1r 134 35 _SP cord-317820-od9l7p1r 135 1 Novel Novel NNP cord-317820-od9l7p1r 135 2 Coronavirus Coronavirus NNP cord-317820-od9l7p1r 135 3 ( ( -LRB- cord-317820-od9l7p1r 135 4 2019-nCoV 2019-ncov CD cord-317820-od9l7p1r 135 5 ) ) -RRB- cord-317820-od9l7p1r 135 6 Situation situation NN cord-317820-od9l7p1r 135 7 Report Report NNP cord-317820-od9l7p1r 135 8 -1 -1 . cord-317820-od9l7p1r 136 1 World World NNP cord-317820-od9l7p1r 136 2 Health Health NNP cord-317820-od9l7p1r 136 3 Organization Organization NNP cord-317820-od9l7p1r 136 4 ( ( -LRB- cord-317820-od9l7p1r 136 5 WHO who WP cord-317820-od9l7p1r 136 6 ) ) -RRB- cord-317820-od9l7p1r 136 7 , , , cord-317820-od9l7p1r 136 8 COVID-19 COVID-19 NNP cord-317820-od9l7p1r 136 9 situation situation NN cord-317820-od9l7p1r 136 10 report report NN cord-317820-od9l7p1r 136 11 148 148 CD cord-317820-od9l7p1r 137 1 The the DT cord-317820-od9l7p1r 137 2 human human JJ cord-317820-od9l7p1r 137 3 coronavirus coronavirus NN cord-317820-od9l7p1r 137 4 disease disease NN cord-317820-od9l7p1r 137 5 covid-19 covid-19 NNP cord-317820-od9l7p1r 137 6 : : : cord-317820-od9l7p1r 137 7 Its -PRON- PRP$ cord-317820-od9l7p1r 137 8 origin origin NN cord-317820-od9l7p1r 137 9 , , , cord-317820-od9l7p1r 137 10 characteristics characteristic NNS cord-317820-od9l7p1r 137 11 , , , cord-317820-od9l7p1r 137 12 and and CC cord-317820-od9l7p1r 137 13 insights insight NNS cord-317820-od9l7p1r 137 14 into into IN cord-317820-od9l7p1r 137 15 potential potential JJ cord-317820-od9l7p1r 137 16 drugs drug NNS cord-317820-od9l7p1r 137 17 and and CC cord-317820-od9l7p1r 137 18 its -PRON- PRP$ cord-317820-od9l7p1r 137 19 mechanisms mechanism NNS cord-317820-od9l7p1r 137 20 , , , cord-317820-od9l7p1r 137 21 Pathogens Pathogens NNPS cord-317820-od9l7p1r 137 22 SARS SARS NNP cord-317820-od9l7p1r 137 23 - - HYPH cord-317820-od9l7p1r 137 24 coV-2 coV-2 NNP cord-317820-od9l7p1r 137 25 : : : cord-317820-od9l7p1r 138 1 An an DT cord-317820-od9l7p1r 138 2 emerging emerge VBG cord-317820-od9l7p1r 138 3 coronavirus coronavirus NN cord-317820-od9l7p1r 138 4 that that WDT cord-317820-od9l7p1r 138 5 causes cause VBZ cord-317820-od9l7p1r 138 6 a a DT cord-317820-od9l7p1r 138 7 global global JJ cord-317820-od9l7p1r 138 8 threat threat NN cord-317820-od9l7p1r 138 9 Clinical Clinical NNP cord-317820-od9l7p1r 138 10 Infectious Infectious NNP cord-317820-od9l7p1r 138 11 Diseases Diseases NNPS cord-317820-od9l7p1r 138 12 : : : cord-317820-od9l7p1r 139 1 An an DT cord-317820-od9l7p1r 139 2 Official Official NNP cord-317820-od9l7p1r 139 3 Publication Publication NNP cord-317820-od9l7p1r 139 4 of of IN cord-317820-od9l7p1r 139 5 the the DT cord-317820-od9l7p1r 139 6 Infectious Infectious NNP cord-317820-od9l7p1r 139 7 Diseases Diseases NNPS cord-317820-od9l7p1r 139 8 Society Society NNP cord-317820-od9l7p1r 139 9 of of IN cord-317820-od9l7p1r 139 10 America America NNP cord-317820-od9l7p1r 139 11 Risk Risk NNP cord-317820-od9l7p1r 139 12 factors factor NNS cord-317820-od9l7p1r 139 13 for for IN cord-317820-od9l7p1r 139 14 severity severity NN cord-317820-od9l7p1r 139 15 and and CC cord-317820-od9l7p1r 139 16 mortality mortality NN cord-317820-od9l7p1r 139 17 in in IN cord-317820-od9l7p1r 139 18 adult adult NN cord-317820-od9l7p1r 139 19 COVID-19 covid-19 JJ cord-317820-od9l7p1r 139 20 inpatients inpatient NNS cord-317820-od9l7p1r 139 21 in in IN cord-317820-od9l7p1r 139 22 Wuhan Wuhan NNP cord-317820-od9l7p1r 139 23 A a DT cord-317820-od9l7p1r 139 24 New new JJ cord-317820-od9l7p1r 139 25 Symptom symptom NN cord-317820-od9l7p1r 139 26 of of IN cord-317820-od9l7p1r 139 27 COVID-19 covid-19 NN cord-317820-od9l7p1r 139 28 : : : cord-317820-od9l7p1r 139 29 Loss loss NN cord-317820-od9l7p1r 139 30 of of IN cord-317820-od9l7p1r 139 31 Taste Taste NNP cord-317820-od9l7p1r 139 32 and and CC cord-317820-od9l7p1r 139 33 Smell Smell NNP cord-317820-od9l7p1r 139 34 Prognostic prognostic JJ cord-317820-od9l7p1r 139 35 value value NN cord-317820-od9l7p1r 139 36 of of IN cord-317820-od9l7p1r 139 37 interleukin-6 interleukin-6 NNP cord-317820-od9l7p1r 139 38 , , , cord-317820-od9l7p1r 139 39 C C NNP cord-317820-od9l7p1r 139 40 - - HYPH cord-317820-od9l7p1r 139 41 reactive reactive JJ cord-317820-od9l7p1r 139 42 protein protein NN cord-317820-od9l7p1r 139 43 , , , cord-317820-od9l7p1r 139 44 and and CC cord-317820-od9l7p1r 139 45 procalcitonin procalcitonin NNS cord-317820-od9l7p1r 139 46 in in IN cord-317820-od9l7p1r 139 47 patients patient NNS cord-317820-od9l7p1r 139 48 with with IN cord-317820-od9l7p1r 139 49 COVID-19 COVID-19 NNP cord-317820-od9l7p1r 139 50 The the DT cord-317820-od9l7p1r 139 51 correlation correlation NN cord-317820-od9l7p1r 139 52 between between IN cord-317820-od9l7p1r 139 53 viral viral JJ cord-317820-od9l7p1r 139 54 clearance clearance NN cord-317820-od9l7p1r 139 55 and and CC cord-317820-od9l7p1r 139 56 biochemical biochemical JJ cord-317820-od9l7p1r 139 57 outcomes outcome NNS cord-317820-od9l7p1r 139 58 of of IN cord-317820-od9l7p1r 139 59 94 94 CD cord-317820-od9l7p1r 140 1 COVID-19 COVID-19 NNP cord-317820-od9l7p1r 140 2 infected infected JJ cord-317820-od9l7p1r 140 3 discharged discharge VBN cord-317820-od9l7p1r 140 4 patients patient NNS cord-317820-od9l7p1r 140 5 Down down RB cord-317820-od9l7p1r 140 6 - - HYPH cord-317820-od9l7p1r 140 7 regulated regulate VBN cord-317820-od9l7p1r 140 8 gene gene NN cord-317820-od9l7p1r 140 9 expression expression NN cord-317820-od9l7p1r 140 10 spectrum spectrum NN cord-317820-od9l7p1r 140 11 and and CC cord-317820-od9l7p1r 140 12 immune immune JJ cord-317820-od9l7p1r 140 13 responses response NNS cord-317820-od9l7p1r 140 14 changed change VBD cord-317820-od9l7p1r 140 15 during during IN cord-317820-od9l7p1r 140 16 the the DT cord-317820-od9l7p1r 140 17 disease disease NN cord-317820-od9l7p1r 140 18 progression progression NN cord-317820-od9l7p1r 140 19 in in IN cord-317820-od9l7p1r 140 20 COVID-19 COVID-19 NNP cord-317820-od9l7p1r 140 21 patients patient NNS cord-317820-od9l7p1r 140 22 Clinical clinical JJ cord-317820-od9l7p1r 140 23 and and CC cord-317820-od9l7p1r 140 24 immunologic immunologic JJ cord-317820-od9l7p1r 140 25 features feature NNS cord-317820-od9l7p1r 140 26 in in IN cord-317820-od9l7p1r 140 27 severe severe JJ cord-317820-od9l7p1r 140 28 and and CC cord-317820-od9l7p1r 140 29 moderate moderate JJ cord-317820-od9l7p1r 140 30 Coronavirus Coronavirus NNP cord-317820-od9l7p1r 140 31 Disease Disease NNP cord-317820-od9l7p1r 140 32 Dysregulation Dysregulation NNP cord-317820-od9l7p1r 140 33 of of IN cord-317820-od9l7p1r 140 34 immune immune JJ cord-317820-od9l7p1r 140 35 response response NN cord-317820-od9l7p1r 140 36 in in IN cord-317820-od9l7p1r 140 37 patients patient NNS cord-317820-od9l7p1r 140 38 with with IN cord-317820-od9l7p1r 140 39 COVID-19 COVID-19 NNP cord-317820-od9l7p1r 140 40 in in IN cord-317820-od9l7p1r 140 41 Wuhan Wuhan NNP cord-317820-od9l7p1r 140 42 , , , cord-317820-od9l7p1r 140 43 China China NNP cord-317820-od9l7p1r 140 44 , , , cord-317820-od9l7p1r 140 45 Clinical Clinical NNP cord-317820-od9l7p1r 140 46 Infectious Infectious NNP cord-317820-od9l7p1r 140 47 Diseases Diseases NNPS cord-317820-od9l7p1r 140 48 : : : cord-317820-od9l7p1r 141 1 An an DT cord-317820-od9l7p1r 141 2 Official Official NNP cord-317820-od9l7p1r 141 3 Publication Publication NNP cord-317820-od9l7p1r 141 4 of of IN cord-317820-od9l7p1r 141 5 the the DT cord-317820-od9l7p1r 141 6 Infectious Infectious NNP cord-317820-od9l7p1r 141 7 Diseases Diseases NNPS cord-317820-od9l7p1r 141 8 Society Society NNP cord-317820-od9l7p1r 141 9 of of IN cord-317820-od9l7p1r 141 10 America America NNP cord-317820-od9l7p1r 142 1 Zhonghua Zhonghua NNP cord-317820-od9l7p1r 142 2 Jie Jie NNP cord-317820-od9l7p1r 143 1 He -PRON- PRP cord-317820-od9l7p1r 144 1 He -PRON- PRP cord-317820-od9l7p1r 144 2 Hu Hu NNP cord-317820-od9l7p1r 145 1 Xi Xi NNP cord-317820-od9l7p1r 145 2 Za Za NNP cord-317820-od9l7p1r 145 3 Zhi Zhi NNP cord-317820-od9l7p1r 145 4 = = : cord-317820-od9l7p1r 146 1 Zhonghua Zhonghua NNP cord-317820-od9l7p1r 146 2 Jiehe Jiehe NNP cord-317820-od9l7p1r 147 1 He -PRON- PRP cord-317820-od9l7p1r 147 2 Huxi Huxi NNP cord-317820-od9l7p1r 147 3 Zazhi Zazhi NNP cord-317820-od9l7p1r 147 4 = = NFP cord-317820-od9l7p1r 148 1 Chinese Chinese NNP cord-317820-od9l7p1r 148 2 Journal Journal NNP cord-317820-od9l7p1r 148 3 of of IN cord-317820-od9l7p1r 148 4 Tuberculosis Tuberculosis NNP cord-317820-od9l7p1r 148 5 and and CC cord-317820-od9l7p1r 148 6 Respiratory Respiratory NNP cord-317820-od9l7p1r 148 7 Diseases Diseases NNPS cord-317820-od9l7p1r 148 8 Suppressed suppress VBD cord-317820-od9l7p1r 148 9 T T NNP cord-317820-od9l7p1r 148 10 cell cell NN cord-317820-od9l7p1r 148 11 - - HYPH cord-317820-od9l7p1r 148 12 mediated mediate VBN cord-317820-od9l7p1r 148 13 immunity immunity NN cord-317820-od9l7p1r 148 14 in in IN cord-317820-od9l7p1r 148 15 patients patient NNS cord-317820-od9l7p1r 148 16 with with IN cord-317820-od9l7p1r 148 17 COVID-19 covid-19 NN cord-317820-od9l7p1r 148 18 : : : cord-317820-od9l7p1r 149 1 A a DT cord-317820-od9l7p1r 149 2 clinical clinical JJ cord-317820-od9l7p1r 149 3 retrospective retrospective JJ cord-317820-od9l7p1r 149 4 study study NN cord-317820-od9l7p1r 149 5 in in IN cord-317820-od9l7p1r 149 6 Wuhan Wuhan NNP cord-317820-od9l7p1r 149 7 Cytokine Cytokine NNP cord-317820-od9l7p1r 149 8 Levels Levels NNP cord-317820-od9l7p1r 149 9 in in IN cord-317820-od9l7p1r 149 10 the the DT cord-317820-od9l7p1r 149 11 Body Body NNP cord-317820-od9l7p1r 149 12 Fluids fluid NNS cord-317820-od9l7p1r 149 13 of of IN cord-317820-od9l7p1r 149 14 a a DT cord-317820-od9l7p1r 149 15 Patient Patient NNP cord-317820-od9l7p1r 149 16 With with IN cord-317820-od9l7p1r 149 17 COVID-19 COVID-19 NNP cord-317820-od9l7p1r 149 18 and and CC cord-317820-od9l7p1r 149 19 Acute acute JJ cord-317820-od9l7p1r 149 20 Respiratory Respiratory NNP cord-317820-od9l7p1r 149 21 Distress Distress NNP cord-317820-od9l7p1r 149 22 Syndrome Syndrome NNP cord-317820-od9l7p1r 149 23 : : : cord-317820-od9l7p1r 150 1 A a DT cord-317820-od9l7p1r 150 2 Case Case NNP cord-317820-od9l7p1r 150 3 Report Report NNP cord-317820-od9l7p1r 150 4 Virological virological JJ cord-317820-od9l7p1r 150 5 assessment assessment NN cord-317820-od9l7p1r 150 6 of of IN cord-317820-od9l7p1r 150 7 hospitalized hospitalize VBN cord-317820-od9l7p1r 150 8 patients patient NNS cord-317820-od9l7p1r 150 9 with with IN cord-317820-od9l7p1r 150 10 COVID-2019 COVID-2019 NNP cord-317820-od9l7p1r 150 11 Detection Detection NNP cord-317820-od9l7p1r 150 12 of of IN cord-317820-od9l7p1r 150 13 SARS SARS NNP cord-317820-od9l7p1r 150 14 - - HYPH cord-317820-od9l7p1r 150 15 CoV-2 CoV-2 NNP cord-317820-od9l7p1r 150 16 in in IN cord-317820-od9l7p1r 150 17 Different different JJ cord-317820-od9l7p1r 150 18 Types type NNS cord-317820-od9l7p1r 150 19 of of IN cord-317820-od9l7p1r 150 20 Clinical Clinical NNP cord-317820-od9l7p1r 150 21 Specimens Specimens NNP cord-317820-od9l7p1r 150 22 Quantitative Quantitative NNP cord-317820-od9l7p1r 150 23 Detection Detection NNP cord-317820-od9l7p1r 150 24 and and CC cord-317820-od9l7p1r 150 25 Viral Viral NNP cord-317820-od9l7p1r 150 26 Load Load NNP cord-317820-od9l7p1r 150 27 Analysis Analysis NNP cord-317820-od9l7p1r 150 28 of of IN cord-317820-od9l7p1r 150 29 SARS SARS NNP cord-317820-od9l7p1r 150 30 - - HYPH cord-317820-od9l7p1r 150 31 CoV-2 CoV-2 NNP cord-317820-od9l7p1r 150 32 in in IN cord-317820-od9l7p1r 150 33 Infected Infected NNP cord-317820-od9l7p1r 150 34 Patients Patients NNP cord-317820-od9l7p1r 150 35 Clinical clinical JJ cord-317820-od9l7p1r 150 36 characteristics characteristic NNS cord-317820-od9l7p1r 150 37 of of IN cord-317820-od9l7p1r 150 38 34 34 CD cord-317820-od9l7p1r 150 39 COVID-19 COVID-19 NNP cord-317820-od9l7p1r 150 40 patients patient NNS cord-317820-od9l7p1r 150 41 admitted admit VBN cord-317820-od9l7p1r 150 42 to to IN cord-317820-od9l7p1r 150 43 intensive intensive JJ cord-317820-od9l7p1r 150 44 care care NN cord-317820-od9l7p1r 150 45 unit unit NN cord-317820-od9l7p1r 150 46 in in IN cord-317820-od9l7p1r 150 47 Hangzhou Hangzhou NNP cord-317820-od9l7p1r 150 48 Clinical Clinical NNP cord-317820-od9l7p1r 150 49 Characteristics Characteristics NNPS cord-317820-od9l7p1r 150 50 of of IN cord-317820-od9l7p1r 150 51 Coronavirus Coronavirus NNP cord-317820-od9l7p1r 150 52 Disease Disease NNP cord-317820-od9l7p1r 150 53 2019 2019 CD cord-317820-od9l7p1r 150 54 in in IN cord-317820-od9l7p1r 150 55 China China NNP cord-317820-od9l7p1r 150 56 Human Human NNP cord-317820-od9l7p1r 150 57 leukocyte leukocyte NN cord-317820-od9l7p1r 150 58 antigen antigen NN cord-317820-od9l7p1r 150 59 susceptibility susceptibility NN cord-317820-od9l7p1r 150 60 map map NN cord-317820-od9l7p1r 150 61 for for IN cord-317820-od9l7p1r 150 62 SARS SARS NNP cord-317820-od9l7p1r 150 63 - - HYPH cord-317820-od9l7p1r 150 64 CoV-2 CoV-2 NNP cord-317820-od9l7p1r 150 65 Clinical Clinical NNP cord-317820-od9l7p1r 150 66 Features Features NNPS cord-317820-od9l7p1r 150 67 and and CC cord-317820-od9l7p1r 150 68 Outcomes Outcomes NNPS cord-317820-od9l7p1r 150 69 of of IN cord-317820-od9l7p1r 150 70 98 98 CD cord-317820-od9l7p1r 150 71 Patients patient NNS cord-317820-od9l7p1r 150 72 Hospitalized hospitalize VBN cord-317820-od9l7p1r 150 73 with with IN cord-317820-od9l7p1r 150 74 SARS SARS NNP cord-317820-od9l7p1r 150 75 - - HYPH cord-317820-od9l7p1r 150 76 CoV-2 CoV-2 NNP cord-317820-od9l7p1r 150 77 Infection Infection NNP cord-317820-od9l7p1r 150 78 in in IN cord-317820-od9l7p1r 150 79 Daegu Daegu NNP cord-317820-od9l7p1r 150 80 , , , cord-317820-od9l7p1r 150 81 South South NNP cord-317820-od9l7p1r 150 82 Korea Korea NNP cord-317820-od9l7p1r 150 83 : : : cord-317820-od9l7p1r 151 1 A a DT cord-317820-od9l7p1r 151 2 Brief brief JJ cord-317820-od9l7p1r 151 3 Descriptive Descriptive NNP cord-317820-od9l7p1r 151 4 Study study NN cord-317820-od9l7p1r 151 5 COVID-19 covid-19 NN cord-317820-od9l7p1r 151 6 : : : cord-317820-od9l7p1r 151 7 consider consider VB cord-317820-od9l7p1r 151 8 cytokine cytokine JJ cord-317820-od9l7p1r 151 9 storm storm NN cord-317820-od9l7p1r 151 10 syndromes syndrome NNS cord-317820-od9l7p1r 151 11 and and CC cord-317820-od9l7p1r 151 12 immunosuppression immunosuppression NN cord-317820-od9l7p1r 151 13 , , , cord-317820-od9l7p1r 151 14 The the DT cord-317820-od9l7p1r 151 15 Lancet Lancet NNP cord-317820-od9l7p1r 151 16 Tocilizumab Tocilizumab NNP cord-317820-od9l7p1r 151 17 in in IN cord-317820-od9l7p1r 151 18 Severe severe JJ cord-317820-od9l7p1r 151 19 COVID-19 COVID-19 NNP cord-317820-od9l7p1r 151 20 Pneumonia Pneumonia NNP cord-317820-od9l7p1r 151 21 and and CC cord-317820-od9l7p1r 151 22 Concomitant concomitant JJ cord-317820-od9l7p1r 151 23 Cytokine cytokine NN cord-317820-od9l7p1r 151 24 Release Release NNP cord-317820-od9l7p1r 151 25 Syndrome syndrome NN cord-317820-od9l7p1r 151 26 Use Use NNP cord-317820-od9l7p1r 151 27 of of IN cord-317820-od9l7p1r 151 28 Tocilizumab Tocilizumab NNP cord-317820-od9l7p1r 151 29 for for IN cord-317820-od9l7p1r 151 30 COVID-19-Induced COVID-19-Induced NNP cord-317820-od9l7p1r 151 31 Cytokine Cytokine NNP cord-317820-od9l7p1r 151 32 Release Release NNP cord-317820-od9l7p1r 151 33 Syndrome syndrome NN cord-317820-od9l7p1r 151 34 : : : cord-317820-od9l7p1r 152 1 A a DT cord-317820-od9l7p1r 152 2 Cautionary Cautionary NNP cord-317820-od9l7p1r 152 3 Case Case NNP cord-317820-od9l7p1r 152 4 Report report NN cord-317820-od9l7p1r 152 5 Longitudinal longitudinal JJ cord-317820-od9l7p1r 152 6 characteristics characteristic NNS cord-317820-od9l7p1r 152 7 of of IN cord-317820-od9l7p1r 152 8 lymphocyte lymphocyte NN cord-317820-od9l7p1r 152 9 responses response NNS cord-317820-od9l7p1r 152 10 and and CC cord-317820-od9l7p1r 152 11 cytokine cytokine NN cord-317820-od9l7p1r 152 12 profiles profile NNS cord-317820-od9l7p1r 152 13 in in IN cord-317820-od9l7p1r 152 14 the the DT cord-317820-od9l7p1r 152 15 peripheral peripheral JJ cord-317820-od9l7p1r 152 16 blood blood NN cord-317820-od9l7p1r 152 17 of of IN cord-317820-od9l7p1r 152 18 SARS SARS NNP cord-317820-od9l7p1r 152 19 - - HYPH cord-317820-od9l7p1r 152 20 CoV-2 CoV-2 NNP cord-317820-od9l7p1r 152 21 infected infect VBN cord-317820-od9l7p1r 152 22 patients patient NNS cord-317820-od9l7p1r 152 23 Clinical clinical JJ cord-317820-od9l7p1r 152 24 and and CC cord-317820-od9l7p1r 152 25 pathological pathological JJ cord-317820-od9l7p1r 152 26 investigation investigation NN cord-317820-od9l7p1r 152 27 of of IN cord-317820-od9l7p1r 152 28 severe severe JJ cord-317820-od9l7p1r 152 29 COVID-19 COVID-19 NNP cord-317820-od9l7p1r 152 30 patients patient NNS cord-317820-od9l7p1r 152 31 Guillain Guillain NNP cord-317820-od9l7p1r 152 32 Barre Barre NNP cord-317820-od9l7p1r 152 33 syndrome syndrome NN cord-317820-od9l7p1r 152 34 associated associate VBN cord-317820-od9l7p1r 152 35 with with IN cord-317820-od9l7p1r 152 36 COVID-19 covid-19 JJ cord-317820-od9l7p1r 152 37 infection infection NN cord-317820-od9l7p1r 152 38 : : : cord-317820-od9l7p1r 153 1 A a DT cord-317820-od9l7p1r 153 2 case case NN cord-317820-od9l7p1r 153 3 report report NN cord-317820-od9l7p1r 153 4 Autoimmune autoimmune JJ cord-317820-od9l7p1r 153 5 hemolytic hemolytic JJ cord-317820-od9l7p1r 153 6 anemia anemia NN cord-317820-od9l7p1r 153 7 associated associate VBN cord-317820-od9l7p1r 153 8 with with IN cord-317820-od9l7p1r 153 9 Covid-19 covid-19 JJ cord-317820-od9l7p1r 153 10 infection infection NN cord-317820-od9l7p1r 153 11 A a DT cord-317820-od9l7p1r 153 12 first first JJ cord-317820-od9l7p1r 153 13 case case NN cord-317820-od9l7p1r 153 14 of of IN cord-317820-od9l7p1r 153 15 meningitis meningitis NN cord-317820-od9l7p1r 153 16 / / SYM cord-317820-od9l7p1r 153 17 encephalitis encephalitis NN cord-317820-od9l7p1r 153 18 associated associate VBN cord-317820-od9l7p1r 153 19 with with IN cord-317820-od9l7p1r 153 20 SARS SARS NNP cord-317820-od9l7p1r 153 21 - - HYPH cord-317820-od9l7p1r 153 22 Coronavirus-2 Coronavirus-2 NNP cord-317820-od9l7p1r 153 23 Mechanism Mechanism NNP cord-317820-od9l7p1r 153 24 of of IN cord-317820-od9l7p1r 153 25 inhibition inhibition NN cord-317820-od9l7p1r 153 26 of of IN cord-317820-od9l7p1r 153 27 ebola ebola NNP cord-317820-od9l7p1r 153 28 virus virus NN cord-317820-od9l7p1r 154 1 RNAdependent RNAdependent NNP cord-317820-od9l7p1r 154 2 RNA RNA NNP cord-317820-od9l7p1r 154 3 polymerase polymerase NN cord-317820-od9l7p1r 154 4 by by IN cord-317820-od9l7p1r 154 5 remdesivir remdesivir NNP cord-317820-od9l7p1r 154 6 Compassionate compassionate JJ cord-317820-od9l7p1r 154 7 Use Use NNP cord-317820-od9l7p1r 154 8 of of IN cord-317820-od9l7p1r 154 9 Remdesivir Remdesivir NNP cord-317820-od9l7p1r 154 10 for for IN cord-317820-od9l7p1r 154 11 Patients patient NNS cord-317820-od9l7p1r 154 12 with with IN cord-317820-od9l7p1r 154 13 Severe severe JJ cord-317820-od9l7p1r 154 14 Covid-19 covid-19 NN cord-317820-od9l7p1r 154 15 Chloroquine Chloroquine NNP cord-317820-od9l7p1r 154 16 inhibits inhibit VBZ cord-317820-od9l7p1r 154 17 autophagic autophagic NN cord-317820-od9l7p1r 154 18 flux flux NN cord-317820-od9l7p1r 154 19 by by IN cord-317820-od9l7p1r 154 20 decreasing decrease VBG cord-317820-od9l7p1r 154 21 autophagosomelysosome autophagosomelysosome NNP cord-317820-od9l7p1r 154 22 fusion fusion NN cord-317820-od9l7p1r 154 23 Update update NN cord-317820-od9l7p1r 154 24 on on IN cord-317820-od9l7p1r 154 25 use use NN cord-317820-od9l7p1r 154 26 of of IN cord-317820-od9l7p1r 154 27 chloroquine chloroquine NN cord-317820-od9l7p1r 154 28 / / SYM cord-317820-od9l7p1r 154 29 hydroxychloroquine hydroxychloroquine NN cord-317820-od9l7p1r 154 30 to to TO cord-317820-od9l7p1r 154 31 treat treat VB cord-317820-od9l7p1r 154 32 coronavirus coronavirus NN cord-317820-od9l7p1r 154 33 disease disease NN cord-317820-od9l7p1r 154 34 2019 2019 CD cord-317820-od9l7p1r 154 35 ( ( -LRB- cord-317820-od9l7p1r 154 36 COVID-19 covid-19 VB cord-317820-od9l7p1r 154 37 ) ) -RRB- cord-317820-od9l7p1r 154 38 Protease Protease NNP cord-317820-od9l7p1r 154 39 Inhibitors Inhibitors NNP cord-317820-od9l7p1r 154 40 for for IN cord-317820-od9l7p1r 154 41 the the DT cord-317820-od9l7p1r 154 42 Treatment Treatment NNP cord-317820-od9l7p1r 154 43 of of IN cord-317820-od9l7p1r 154 44 HIV HIV NNP cord-317820-od9l7p1r 154 45 / / SYM cord-317820-od9l7p1r 154 46 AIDS AIDS NNP cord-317820-od9l7p1r 154 47 : : : cord-317820-od9l7p1r 155 1 Recent recent JJ cord-317820-od9l7p1r 155 2 Advances Advances NNPS cord-317820-od9l7p1r 155 3 and and CC cord-317820-od9l7p1r 155 4 Future Future NNP cord-317820-od9l7p1r 155 5 Challenges Challenges NNP cord-317820-od9l7p1r 155 6 Effectiveness Effectiveness NNP cord-317820-od9l7p1r 155 7 of of IN cord-317820-od9l7p1r 155 8 convalescent convalescent JJ cord-317820-od9l7p1r 155 9 plasma plasma NN cord-317820-od9l7p1r 155 10 therapy therapy NN cord-317820-od9l7p1r 155 11 in in IN cord-317820-od9l7p1r 155 12 severe severe JJ cord-317820-od9l7p1r 155 13 COVID-19 COVID-19 NNP cord-317820-od9l7p1r 155 14 patients patient NNS cord-317820-od9l7p1r 155 15 Safety Safety NNP cord-317820-od9l7p1r 155 16 in in IN cord-317820-od9l7p1r 155 17 Convalescent Convalescent NNP cord-317820-od9l7p1r 155 18 Plasma Plasma NNP cord-317820-od9l7p1r 155 19 Transfusion Transfusion NNP cord-317820-od9l7p1r 155 20 to to TO cord-317820-od9l7p1r 155 21 COVID-19 covid-19 VB cord-317820-od9l7p1r 155 22 NCT04345523 NCT04345523 NNP cord-317820-od9l7p1r 155 23 , , , cord-317820-od9l7p1r 155 24 Convalescent Convalescent NNP cord-317820-od9l7p1r 155 25 Plasma Plasma NNP cord-317820-od9l7p1r 155 26 Therapy Therapy NNP cord-317820-od9l7p1r 155 27 vs. vs. FW cord-317820-od9l7p1r 155 28 SOC SOC NNP cord-317820-od9l7p1r 155 29 for for IN cord-317820-od9l7p1r 155 30 the the DT cord-317820-od9l7p1r 155 31 Treatment Treatment NNP cord-317820-od9l7p1r 155 32 of of IN cord-317820-od9l7p1r 155 33 COVID19 COVID19 NNP cord-317820-od9l7p1r 155 34 in in IN cord-317820-od9l7p1r 156 1 Hospitalized hospitalized JJ cord-317820-od9l7p1r 156 2 Patients Patients NNP cord-317820-od9l7p1r 156 3 Anticoagulant anticoagulant JJ cord-317820-od9l7p1r 156 4 treatment treatment NN cord-317820-od9l7p1r 156 5 is be VBZ cord-317820-od9l7p1r 156 6 associated associate VBN cord-317820-od9l7p1r 156 7 with with IN cord-317820-od9l7p1r 156 8 decreased decrease VBN cord-317820-od9l7p1r 156 9 mortality mortality NN cord-317820-od9l7p1r 156 10 in in IN cord-317820-od9l7p1r 156 11 severe severe JJ cord-317820-od9l7p1r 156 12 coronavirus coronavirus NN cord-317820-od9l7p1r 156 13 disease disease NN cord-317820-od9l7p1r 156 14 2019 2019 CD cord-317820-od9l7p1r 156 15 patients patient NNS cord-317820-od9l7p1r 156 16 with with IN cord-317820-od9l7p1r 156 17 coagulopathy coagulopathy NN cord-317820-od9l7p1r 156 18 Assessing assess VBG cord-317820-od9l7p1r 156 19 ACE2 ACE2 NNP cord-317820-od9l7p1r 156 20 expression expression NN cord-317820-od9l7p1r 156 21 patterns pattern NNS cord-317820-od9l7p1r 156 22 in in IN cord-317820-od9l7p1r 156 23 lung lung NN cord-317820-od9l7p1r 156 24 tissues tissue NNS cord-317820-od9l7p1r 156 25 in in IN cord-317820-od9l7p1r 156 26 the the DT cord-317820-od9l7p1r 156 27 pathogenesis pathogenesis NN cord-317820-od9l7p1r 156 28 of of IN cord-317820-od9l7p1r 156 29 COVID-19 COVID-19 NNP cord-317820-od9l7p1r 156 30 TMPRSS2 TMPRSS2 NNP cord-317820-od9l7p1r 156 31 and and CC cord-317820-od9l7p1r 156 32 J J NNP cord-317820-od9l7p1r 156 33 o o NN cord-317820-od9l7p1r 156 34 u u NN cord-317820-od9l7p1r 156 35 r r NN cord-317820-od9l7p1r 156 36 n n NN cord-317820-od9l7p1r 156 37 a a DT cord-317820-od9l7p1r 156 38 l l NN cord-317820-od9l7p1r 156 39 P p NN cord-317820-od9l7p1r 156 40 r r NN cord-317820-od9l7p1r 156 41 e e NN cord-317820-od9l7p1r 156 42 -p -p NN cord-317820-od9l7p1r 157 1 r r LS cord-317820-od9l7p1r 158 1 o o UH cord-317820-od9l7p1r 159 1 o o UH cord-317820-od9l7p1r 159 2 f f NNP cord-317820-od9l7p1r 160 1 TMPRSS4 TMPRSS4 NNP cord-317820-od9l7p1r 160 2 mediate mediate VB cord-317820-od9l7p1r 160 3 SARS SARS NNP cord-317820-od9l7p1r 160 4 - - HYPH cord-317820-od9l7p1r 160 5 CoV-2 CoV-2 NNP cord-317820-od9l7p1r 160 6 infection infection NN cord-317820-od9l7p1r 160 7 of of IN cord-317820-od9l7p1r 160 8 human human JJ cord-317820-od9l7p1r 160 9 small small JJ cord-317820-od9l7p1r 160 10 intestinal intestinal JJ cord-317820-od9l7p1r 160 11 enterocytes enterocyte NNS cord-317820-od9l7p1r 160 12 Increased increase VBN cord-317820-od9l7p1r 160 13 expression expression NN cord-317820-od9l7p1r 160 14 of of IN cord-317820-od9l7p1r 160 15 CD8 CD8 NNP cord-317820-od9l7p1r 160 16 marker marker NN cord-317820-od9l7p1r 160 17 on on IN cord-317820-od9l7p1r 160 18 T T NNP cord-317820-od9l7p1r 160 19 - - HYPH cord-317820-od9l7p1r 160 20 cells cell NNS cord-317820-od9l7p1r 160 21 in in IN cord-317820-od9l7p1r 160 22 COVID-19 covid-19 CD cord-317820-od9l7p1r 160 23 patients patient NNS cord-317820-od9l7p1r 160 24 Transcriptomic Transcriptomic NNP cord-317820-od9l7p1r 160 25 characteristics characteristic NNS cord-317820-od9l7p1r 160 26 of of IN cord-317820-od9l7p1r 160 27 bronchoalveolar bronchoalveolar NNP cord-317820-od9l7p1r 160 28 lavage lavage NN cord-317820-od9l7p1r 160 29 fluid fluid NN cord-317820-od9l7p1r 160 30 and and CC cord-317820-od9l7p1r 160 31 peripheral peripheral JJ cord-317820-od9l7p1r 160 32 blood blood NN cord-317820-od9l7p1r 160 33 mononuclear mononuclear NN cord-317820-od9l7p1r 160 34 cells cell NNS cord-317820-od9l7p1r 160 35 in in IN cord-317820-od9l7p1r 160 36 COVID-19 covid-19 JJ cord-317820-od9l7p1r 160 37 patients patient NNS cord-317820-od9l7p1r 160 38 , , , cord-317820-od9l7p1r 160 39 Emerging emerge VBG cord-317820-od9l7p1r 160 40 Microbes Microbes NNPS cord-317820-od9l7p1r 160 41 and and CC cord-317820-od9l7p1r 160 42 Infections Infections NNPS cord-317820-od9l7p1r 160 43 Reduction Reduction NNP cord-317820-od9l7p1r 160 44 and and CC cord-317820-od9l7p1r 160 45 Functional functional JJ cord-317820-od9l7p1r 160 46 Exhaustion exhaustion NN cord-317820-od9l7p1r 160 47 of of IN cord-317820-od9l7p1r 160 48 T T NNP cord-317820-od9l7p1r 160 49 Cells cell NNS cord-317820-od9l7p1r 160 50 in in IN cord-317820-od9l7p1r 160 51 Patients patient NNS cord-317820-od9l7p1r 160 52 with with IN cord-317820-od9l7p1r 160 53 Coronavirus Coronavirus NNP cord-317820-od9l7p1r 160 54 Disease Disease NNP cord-317820-od9l7p1r 160 55 Functional functional JJ cord-317820-od9l7p1r 160 56 exhaustion exhaustion NN cord-317820-od9l7p1r 160 57 of of IN cord-317820-od9l7p1r 160 58 antiviral antiviral JJ cord-317820-od9l7p1r 160 59 lymphocytes lymphocyte NNS cord-317820-od9l7p1r 160 60 in in IN cord-317820-od9l7p1r 160 61 COVID-19 covid-19 JJ cord-317820-od9l7p1r 160 62 patients patient NNS cord-317820-od9l7p1r 160 63 , , , cord-317820-od9l7p1r 160 64 Cellular Cellular NNP cord-317820-od9l7p1r 160 65 and and CC cord-317820-od9l7p1r 160 66 Molecular Molecular NNP cord-317820-od9l7p1r 160 67 Immunology Immunology NNP cord-317820-od9l7p1r 160 68 Plasma Plasma NNP cord-317820-od9l7p1r 160 69 IP-10 IP-10 NNP cord-317820-od9l7p1r 160 70 and and CC cord-317820-od9l7p1r 160 71 MCP-3 MCP-3 NNP cord-317820-od9l7p1r 160 72 levels level NNS cord-317820-od9l7p1r 160 73 are be VBP cord-317820-od9l7p1r 160 74 highly highly RB cord-317820-od9l7p1r 160 75 associated associate VBN cord-317820-od9l7p1r 160 76 with with IN cord-317820-od9l7p1r 160 77 disease disease NN cord-317820-od9l7p1r 160 78 severity severity NN cord-317820-od9l7p1r 160 79 and and CC cord-317820-od9l7p1r 160 80 predict predict VB cord-317820-od9l7p1r 160 81 the the DT cord-317820-od9l7p1r 160 82 progression progression NN cord-317820-od9l7p1r 160 83 of of IN cord-317820-od9l7p1r 160 84 COVID-19 COVID-19 NNP cord-317820-od9l7p1r 160 85 Relationships Relationships NNPS cord-317820-od9l7p1r 160 86 among among IN cord-317820-od9l7p1r 160 87 lymphocyte lymphocyte NN cord-317820-od9l7p1r 160 88 subsets subset NNS cord-317820-od9l7p1r 160 89 , , , cord-317820-od9l7p1r 160 90 cytokines cytokine NNS cord-317820-od9l7p1r 160 91 , , , cord-317820-od9l7p1r 160 92 and and CC cord-317820-od9l7p1r 160 93 the the DT cord-317820-od9l7p1r 160 94 pulmonary pulmonary JJ cord-317820-od9l7p1r 160 95 inflammation inflammation NN cord-317820-od9l7p1r 160 96 index index NN cord-317820-od9l7p1r 160 97 in in IN cord-317820-od9l7p1r 160 98 coronavirus coronavirus NN cord-317820-od9l7p1r 160 99 ( ( -LRB- cord-317820-od9l7p1r 160 100 COVID-19 covid-19 VB cord-317820-od9l7p1r 160 101 ) ) -RRB- cord-317820-od9l7p1r 160 102 infected infect VBN cord-317820-od9l7p1r 160 103 patients patient NNS cord-317820-od9l7p1r 160 104 ACE-2 ACE-2 NNP cord-317820-od9l7p1r 160 105 Expression expression NN cord-317820-od9l7p1r 160 106 in in IN cord-317820-od9l7p1r 160 107 the the DT cord-317820-od9l7p1r 160 108 Small Small NNP cord-317820-od9l7p1r 160 109 Airway Airway NNP cord-317820-od9l7p1r 160 110 Epithelia Epithelia NNP cord-317820-od9l7p1r 160 111 of of IN cord-317820-od9l7p1r 160 112 Smokers Smokers NNPS cord-317820-od9l7p1r 160 113 and and CC cord-317820-od9l7p1r 160 114 COPD COPD NNP cord-317820-od9l7p1r 160 115 Patients patient NNS cord-317820-od9l7p1r 160 116 : : : cord-317820-od9l7p1r 160 117 Implications implication NNS cord-317820-od9l7p1r 160 118 for for IN cord-317820-od9l7p1r 160 119 COVID-19 COVID-19 NNP cord-317820-od9l7p1r 160 120 Cytokines Cytokines NNPS cord-317820-od9l7p1r 160 121 , , , cord-317820-od9l7p1r 160 122 inflammation inflammation NN cord-317820-od9l7p1r 160 123 , , , cord-317820-od9l7p1r 160 124 and and CC cord-317820-od9l7p1r 160 125 pain pain NN cord-317820-od9l7p1r 160 126 Mechanisms Mechanisms NNPS cord-317820-od9l7p1r 160 127 of of IN cord-317820-od9l7p1r 160 128 Jak Jak NNP cord-317820-od9l7p1r 160 129 / / SYM cord-317820-od9l7p1r 160 130 STAT STAT NNP cord-317820-od9l7p1r 160 131 Signaling signal VBG cord-317820-od9l7p1r 160 132 in in IN cord-317820-od9l7p1r 160 133 Immunity Immunity NNP cord-317820-od9l7p1r 160 134 and and CC cord-317820-od9l7p1r 160 135 Disease Disease NNP cord-317820-od9l7p1r 160 136 Molecular Molecular NNP cord-317820-od9l7p1r 160 137 structure structure NN cord-317820-od9l7p1r 160 138 and and CC cord-317820-od9l7p1r 160 139 function function NN cord-317820-od9l7p1r 160 140 of of IN cord-317820-od9l7p1r 160 141 Janus Janus NNP cord-317820-od9l7p1r 160 142 kinases kinase NNS cord-317820-od9l7p1r 160 143 : : : cord-317820-od9l7p1r 160 144 implications implication NNS cord-317820-od9l7p1r 160 145 for for IN cord-317820-od9l7p1r 160 146 the the DT cord-317820-od9l7p1r 160 147 development development NN cord-317820-od9l7p1r 160 148 of of IN cord-317820-od9l7p1r 160 149 inhibitors inhibitor NNS cord-317820-od9l7p1r 161 1 The the DT cord-317820-od9l7p1r 161 2 role role NN cord-317820-od9l7p1r 161 3 of of IN cord-317820-od9l7p1r 161 4 JAK JAK NNP cord-317820-od9l7p1r 161 5 - - HYPH cord-317820-od9l7p1r 161 6 STAT STAT NNP cord-317820-od9l7p1r 161 7 signaling signal VBG cord-317820-od9l7p1r 161 8 pathway pathway NN cord-317820-od9l7p1r 161 9 and and CC cord-317820-od9l7p1r 161 10 its -PRON- PRP$ cord-317820-od9l7p1r 161 11 regulators regulator NNS cord-317820-od9l7p1r 161 12 in in IN cord-317820-od9l7p1r 161 13 the the DT cord-317820-od9l7p1r 161 14 fate fate NN cord-317820-od9l7p1r 161 15 of of IN cord-317820-od9l7p1r 161 16 T T NNP cord-317820-od9l7p1r 161 17 helper helper NN cord-317820-od9l7p1r 161 18 cells cell NNS cord-317820-od9l7p1r 161 19 Cytokine cytokine NN cord-317820-od9l7p1r 161 20 signaling signal VBG cord-317820-od9l7p1r 161 21 in in IN cord-317820-od9l7p1r 161 22 tumor tumor NN cord-317820-od9l7p1r 161 23 progression progression NN cord-317820-od9l7p1r 162 1 The the DT cord-317820-od9l7p1r 162 2 role role NN cord-317820-od9l7p1r 162 3 of of IN cord-317820-od9l7p1r 162 4 interleukin interleukin NN cord-317820-od9l7p1r 162 5 6 6 CD cord-317820-od9l7p1r 162 6 during during IN cord-317820-od9l7p1r 162 7 viral viral JJ cord-317820-od9l7p1r 162 8 infections infection NNS cord-317820-od9l7p1r 162 9 Comparison comparison NN cord-317820-od9l7p1r 162 10 of of IN cord-317820-od9l7p1r 162 11 baricitinib baricitinib NNP cord-317820-od9l7p1r 162 12 , , , cord-317820-od9l7p1r 162 13 upadacitinib upadacitinib NN cord-317820-od9l7p1r 162 14 , , , cord-317820-od9l7p1r 162 15 and and CC cord-317820-od9l7p1r 162 16 tofacitinib tofacitinib NNP cord-317820-od9l7p1r 162 17 mediated mediate VBD cord-317820-od9l7p1r 162 18 regulation regulation NN cord-317820-od9l7p1r 162 19 of of IN cord-317820-od9l7p1r 162 20 cytokine cytokine NN cord-317820-od9l7p1r 162 21 signaling signal VBG cord-317820-od9l7p1r 162 22 in in IN cord-317820-od9l7p1r 162 23 human human JJ cord-317820-od9l7p1r 162 24 leukocyte leukocyte NN cord-317820-od9l7p1r 162 25 subpopulations subpopulation NNS cord-317820-od9l7p1r 162 26 Peficitinib Peficitinib NNP cord-317820-od9l7p1r 162 27 : : : cord-317820-od9l7p1r 162 28 First First NNP cord-317820-od9l7p1r 162 29 Global Global NNP cord-317820-od9l7p1r 162 30 Approval Approval NNP cord-317820-od9l7p1r 162 31 Baricitinib Baricitinib NNP cord-317820-od9l7p1r 162 32 as as IN cord-317820-od9l7p1r 162 33 potential potential JJ cord-317820-od9l7p1r 162 34 treatment treatment NN cord-317820-od9l7p1r 162 35 for for IN cord-317820-od9l7p1r 162 36 2019-nCoV 2019-ncov CD cord-317820-od9l7p1r 162 37 acute acute JJ cord-317820-od9l7p1r 162 38 respiratory respiratory JJ cord-317820-od9l7p1r 162 39 disease disease NN cord-317820-od9l7p1r 162 40 Tocilizumab tocilizumab JJ cord-317820-od9l7p1r 162 41 treatment treatment NN cord-317820-od9l7p1r 162 42 in in IN cord-317820-od9l7p1r 162 43 COVID-19 COVID-19 NNP cord-317820-od9l7p1r 162 44 : : : cord-317820-od9l7p1r 162 45 A a DT cord-317820-od9l7p1r 162 46 single single JJ cord-317820-od9l7p1r 162 47 center center NN cord-317820-od9l7p1r 162 48 experience experience NN cord-317820-od9l7p1r 162 49 Ruxolitinib Ruxolitinib NNP cord-317820-od9l7p1r 162 50 and and CC cord-317820-od9l7p1r 162 51 effect effect NN cord-317820-od9l7p1r 162 52 mechanisms mechanism NNS cord-317820-od9l7p1r 163 1 Could Could MD cord-317820-od9l7p1r 163 2 ruxolitinib ruxolitinib NNP cord-317820-od9l7p1r 163 3 be be VB cord-317820-od9l7p1r 163 4 effective effective JJ cord-317820-od9l7p1r 163 5 in in IN cord-317820-od9l7p1r 163 6 patients patient NNS cord-317820-od9l7p1r 163 7 with with IN cord-317820-od9l7p1r 163 8 COVID-19 covid-19 JJ cord-317820-od9l7p1r 163 9 infection infection NN cord-317820-od9l7p1r 163 10 at at IN cord-317820-od9l7p1r 163 11 risk risk NN cord-317820-od9l7p1r 163 12 of of IN cord-317820-od9l7p1r 163 13 acute acute JJ cord-317820-od9l7p1r 163 14 respiratory respiratory JJ cord-317820-od9l7p1r 163 15 distress distress NN cord-317820-od9l7p1r 163 16 syndrome syndrome NN cord-317820-od9l7p1r 163 17 ( ( -LRB- cord-317820-od9l7p1r 163 18 ARDS ARDS NNP cord-317820-od9l7p1r 163 19 ) ) -RRB- cord-317820-od9l7p1r 163 20 ? ? . cord-317820-od9l7p1r 164 1 Ruxolitinib Ruxolitinib NNP cord-317820-od9l7p1r 164 2 Regulates regulate VBZ cord-317820-od9l7p1r 164 3 the the DT cord-317820-od9l7p1r 164 4 Autophagy Autophagy NNP cord-317820-od9l7p1r 164 5 Machinery Machinery NNP cord-317820-od9l7p1r 164 6 in in IN cord-317820-od9l7p1r 164 7 Multiple Multiple NNP cord-317820-od9l7p1r 164 8 Myeloma Myeloma NNP cord-317820-od9l7p1r 164 9 Cells Cells NNPS cord-317820-od9l7p1r 164 10 , , , cord-317820-od9l7p1r 164 11 Anti Anti NNP cord-317820-od9l7p1r 164 12 - - NNP cord-317820-od9l7p1r 164 13 Cancer Cancer NNP cord-317820-od9l7p1r 164 14 Agents Agents NNPS cord-317820-od9l7p1r 164 15 in in IN cord-317820-od9l7p1r 164 16 Medicinal Medicinal NNP cord-317820-od9l7p1r 164 17 Chemistry Chemistry NNP cord-317820-od9l7p1r 164 18 Ruxolitinib Ruxolitinib NNP cord-317820-od9l7p1r 164 19 treatment treatment NN cord-317820-od9l7p1r 164 20 for for IN cord-317820-od9l7p1r 164 21 steroid steroid NN cord-317820-od9l7p1r 164 22 refractory refractory JJ cord-317820-od9l7p1r 164 23 acute acute JJ cord-317820-od9l7p1r 164 24 and and CC cord-317820-od9l7p1r 164 25 chronic chronic JJ cord-317820-od9l7p1r 164 26 graft graft NN cord-317820-od9l7p1r 164 27 vs vs IN cord-317820-od9l7p1r 164 28 host host NN cord-317820-od9l7p1r 164 29 disease disease NN cord-317820-od9l7p1r 164 30 in in IN cord-317820-od9l7p1r 164 31 children child NNS cord-317820-od9l7p1r 164 32 : : : cord-317820-od9l7p1r 164 33 Clinical clinical JJ cord-317820-od9l7p1r 164 34 and and CC cord-317820-od9l7p1r 164 35 immunological immunological JJ cord-317820-od9l7p1r 164 36 results result NNS cord-317820-od9l7p1r 164 37 Ruxolitinib ruxolitinib JJ cord-317820-od9l7p1r 164 38 treatment treatment NN cord-317820-od9l7p1r 164 39 for for IN cord-317820-od9l7p1r 164 40 SR SR NNP cord-317820-od9l7p1r 164 41 - - HYPH cord-317820-od9l7p1r 164 42 aGVHD aGVHD NNP cord-317820-od9l7p1r 165 1 in in IN cord-317820-od9l7p1r 165 2 patients patient NNS cord-317820-od9l7p1r 165 3 with with IN cord-317820-od9l7p1r 165 4 EBV EBV NNP cord-317820-od9l7p1r 165 5 - - HYPH cord-317820-od9l7p1r 165 6 HLH HLH NNP cord-317820-od9l7p1r 165 7 undergoing undergo VBG cord-317820-od9l7p1r 165 8 allo allo NN cord-317820-od9l7p1r 165 9 - - HYPH cord-317820-od9l7p1r 165 10 HSCT HSCT NNP cord-317820-od9l7p1r 165 11 Ruxolitinib Ruxolitinib NNP cord-317820-od9l7p1r 165 12 and and CC cord-317820-od9l7p1r 165 13 tofacitinib tofacitinib NNP cord-317820-od9l7p1r 165 14 are be VBP cord-317820-od9l7p1r 165 15 potent potent JJ cord-317820-od9l7p1r 165 16 and and CC cord-317820-od9l7p1r 165 17 selective selective JJ cord-317820-od9l7p1r 165 18 inhibitors inhibitor NNS cord-317820-od9l7p1r 165 19 of of IN cord-317820-od9l7p1r 165 20 HIV-1 HIV-1 NNP cord-317820-od9l7p1r 165 21 replication replication NN cord-317820-od9l7p1r 165 22 and and CC cord-317820-od9l7p1r 165 23 virus virus NN cord-317820-od9l7p1r 165 24 reactivation reactivation NN cord-317820-od9l7p1r 165 25 in in IN cord-317820-od9l7p1r 165 26 vitro vitro FW cord-317820-od9l7p1r 165 27 Novel novel NN cord-317820-od9l7p1r 165 28 mechanisms mechanism NNS cord-317820-od9l7p1r 165 29 to to TO cord-317820-od9l7p1r 165 30 inhibit inhibit VB cord-317820-od9l7p1r 165 31 HIV HIV NNP cord-317820-od9l7p1r 165 32 reservoir reservoir NN cord-317820-od9l7p1r 165 33 seeding seeding NN cord-317820-od9l7p1r 165 34 using use VBG cord-317820-od9l7p1r 165 35 Jak Jak NNP cord-317820-od9l7p1r 165 36 inhibitors inhibitor NNS cord-317820-od9l7p1r 165 37 IL-15 IL-15 NNP cord-317820-od9l7p1r 165 38 regulates regulate VBZ cord-317820-od9l7p1r 165 39 susceptibility susceptibility NN cord-317820-od9l7p1r 165 40 of of IN cord-317820-od9l7p1r 165 41 CD4 CD4 NNP cord-317820-od9l7p1r 165 42 + + CC cord-317820-od9l7p1r 165 43 T T NNP cord-317820-od9l7p1r 165 44 cells cell NNS cord-317820-od9l7p1r 165 45 to to IN cord-317820-od9l7p1r 165 46 HIV HIV NNP cord-317820-od9l7p1r 165 47 infection infection NN cord-317820-od9l7p1r 166 1 Janus Janus NNP cord-317820-od9l7p1r 166 2 kinase kinase VBZ cord-317820-od9l7p1r 166 3 inhibition inhibition NN cord-317820-od9l7p1r 166 4 suppresses suppress VBZ cord-317820-od9l7p1r 166 5 PKC PKC NNP cord-317820-od9l7p1r 166 6 - - HYPH cord-317820-od9l7p1r 166 7 induced induce VBN cord-317820-od9l7p1r 166 8 cytokine cytokine NN cord-317820-od9l7p1r 166 9 release release NN cord-317820-od9l7p1r 166 10 without without IN cord-317820-od9l7p1r 166 11 affecting affect VBG cord-317820-od9l7p1r 166 12 HIV-1 HIV-1 NNP cord-317820-od9l7p1r 166 13 latency latency NN cord-317820-od9l7p1r 166 14 reversal reversal NN cord-317820-od9l7p1r 166 15 ex ex FW cord-317820-od9l7p1r 166 16 vivo vivo NN cord-317820-od9l7p1r 166 17 STAT3 STAT3 NNP cord-317820-od9l7p1r 166 18 is be VBZ cord-317820-od9l7p1r 166 19 constitutively constitutively RB cord-317820-od9l7p1r 166 20 activated activate VBN cord-317820-od9l7p1r 166 21 in in IN cord-317820-od9l7p1r 166 22 chronic chronic JJ cord-317820-od9l7p1r 166 23 active active JJ cord-317820-od9l7p1r 166 24 Epstein Epstein NNP cord-317820-od9l7p1r 166 25 - - HYPH cord-317820-od9l7p1r 166 26 Barr Barr NNP cord-317820-od9l7p1r 166 27 virus virus NN cord-317820-od9l7p1r 166 28 infection infection NN cord-317820-od9l7p1r 166 29 and and CC cord-317820-od9l7p1r 166 30 can can MD cord-317820-od9l7p1r 166 31 be be VB cord-317820-od9l7p1r 166 32 a a DT cord-317820-od9l7p1r 166 33 therapeutic therapeutic JJ cord-317820-od9l7p1r 166 34 target target NN cord-317820-od9l7p1r 166 35 Long long JJ cord-317820-od9l7p1r 166 36 - - HYPH cord-317820-od9l7p1r 166 37 term term NN cord-317820-od9l7p1r 166 38 survival survival NN cord-317820-od9l7p1r 166 39 benefit benefit NN cord-317820-od9l7p1r 166 40 of of IN cord-317820-od9l7p1r 166 41 ruxolitinib ruxolitinib NN cord-317820-od9l7p1r 166 42 in in IN cord-317820-od9l7p1r 166 43 a a DT cord-317820-od9l7p1r 166 44 patient patient NN cord-317820-od9l7p1r 166 45 with with IN cord-317820-od9l7p1r 166 46 relapsed relapse VBN cord-317820-od9l7p1r 166 47 refractory refractory JJ cord-317820-od9l7p1r 166 48 chronic chronic NN cord-317820-od9l7p1r 166 49 active active JJ cord-317820-od9l7p1r 166 50 Epstein Epstein NNP cord-317820-od9l7p1r 166 51 - - HYPH cord-317820-od9l7p1r 166 52 Barr Barr NNP cord-317820-od9l7p1r 166 53 virus virus NN cord-317820-od9l7p1r 166 54 Fatal fatal JJ cord-317820-od9l7p1r 166 55 encephalopathy encephalopathy NN cord-317820-od9l7p1r 166 56 with with IN cord-317820-od9l7p1r 166 57 wild wild JJ cord-317820-od9l7p1r 166 58 - - HYPH cord-317820-od9l7p1r 166 59 type type NN cord-317820-od9l7p1r 166 60 JC JC NNP cord-317820-od9l7p1r 166 61 virus virus NN cord-317820-od9l7p1r 166 62 and and CC cord-317820-od9l7p1r 166 63 ruxolitinib ruxolitinib JJ cord-317820-od9l7p1r 166 64 therapy therapy NN cord-317820-od9l7p1r 167 1 Fatal fatal JJ cord-317820-od9l7p1r 168 1 ruxolitinib ruxolitinib JJ cord-317820-od9l7p1r 168 2 - - HYPH cord-317820-od9l7p1r 168 3 related relate VBN cord-317820-od9l7p1r 168 4 JC JC NNP cord-317820-od9l7p1r 168 5 virus virus NN cord-317820-od9l7p1r 168 6 meningitis meningitis NN cord-317820-od9l7p1r 168 7 Jak Jak NNP cord-317820-od9l7p1r 168 8 Inhibitors Inhibitors NNP cord-317820-od9l7p1r 168 9 Modulate modulate VBP cord-317820-od9l7p1r 169 1 Production production NN cord-317820-od9l7p1r 169 2 of of IN cord-317820-od9l7p1r 169 3 Replication Replication NNP cord-317820-od9l7p1r 169 4 Competent Competent NNP cord-317820-od9l7p1r 169 5 Zika Zika NNP cord-317820-od9l7p1r 169 6 Virus Virus NNP cord-317820-od9l7p1r 169 7 in in IN cord-317820-od9l7p1r 169 8 Human Human NNP cord-317820-od9l7p1r 169 9 Hofbauer Hofbauer NNP cord-317820-od9l7p1r 169 10 , , , cord-317820-od9l7p1r 169 11 Trophoblasts Trophoblasts NNPS cord-317820-od9l7p1r 169 12 , , , cord-317820-od9l7p1r 169 13 and and CC cord-317820-od9l7p1r 169 14 Neuroblastoma neuroblastoma NN cord-317820-od9l7p1r 169 15 cells cell NNS cord-317820-od9l7p1r 169 16 , , , cord-317820-od9l7p1r 169 17 Pathogens Pathogens NNPS cord-317820-od9l7p1r 169 18 and and CC cord-317820-od9l7p1r 169 19 Immunity Immunity NNP cord-317820-od9l7p1r 169 20 Myxovirus Myxovirus NNP cord-317820-od9l7p1r 169 21 resistance resistance NN cord-317820-od9l7p1r 169 22 protein protein NN cord-317820-od9l7p1r 169 23 A A NNP cord-317820-od9l7p1r 169 24 inhibits inhibit VBZ cord-317820-od9l7p1r 169 25 hepatitis hepatitis NN cord-317820-od9l7p1r 169 26 C c NN cord-317820-od9l7p1r 169 27 virus virus NN cord-317820-od9l7p1r 169 28 replication replication NN cord-317820-od9l7p1r 169 29 through through IN cord-317820-od9l7p1r 169 30 JAK JAK NNP cord-317820-od9l7p1r 169 31 - - HYPH cord-317820-od9l7p1r 169 32 STAT STAT NNP cord-317820-od9l7p1r 169 33 pathway pathway NN cord-317820-od9l7p1r 169 34 activation activation NN cord-317820-od9l7p1r 169 35 Occult Occult NNP cord-317820-od9l7p1r 169 36 hepatitis hepatitis NN cord-317820-od9l7p1r 169 37 B B NNP cord-317820-od9l7p1r 169 38 infection infection NN cord-317820-od9l7p1r 169 39 reactivation reactivation NN cord-317820-od9l7p1r 169 40 after after IN cord-317820-od9l7p1r 169 41 ruxolitinib ruxolitinib JJ cord-317820-od9l7p1r 169 42 therapy therapy NN cord-317820-od9l7p1r 169 43 Epstein Epstein NNP cord-317820-od9l7p1r 169 44 - - HYPH cord-317820-od9l7p1r 169 45 Barr Barr NNP cord-317820-od9l7p1r 169 46 virus virus NN cord-317820-od9l7p1r 169 47 gastric gastric JJ cord-317820-od9l7p1r 169 48 ulcer ulcer NN cord-317820-od9l7p1r 169 49 associated associate VBN cord-317820-od9l7p1r 169 50 with with IN cord-317820-od9l7p1r 169 51 ruxolitinib ruxolitinib JJ cord-317820-od9l7p1r 169 52 Varicella Varicella NNP cord-317820-od9l7p1r 169 53 - - HYPH cord-317820-od9l7p1r 169 54 zoster zoster NNP cord-317820-od9l7p1r 169 55 virus virus NN cord-317820-od9l7p1r 169 56 meningoencephalitis meningoencephalitis NNP cord-317820-od9l7p1r 169 57 in in IN cord-317820-od9l7p1r 169 58 a a DT cord-317820-od9l7p1r 169 59 patient patient NN cord-317820-od9l7p1r 169 60 treated treat VBN cord-317820-od9l7p1r 169 61 with with IN cord-317820-od9l7p1r 169 62 ruxolitinib ruxolitinib JJ cord-317820-od9l7p1r 169 63 Cytomegalovirus Cytomegalovirus NNP cord-317820-od9l7p1r 169 64 Retinitis Retinitis NNP cord-317820-od9l7p1r 169 65 in in IN cord-317820-od9l7p1r 169 66 a a DT cord-317820-od9l7p1r 169 67 Patient patient NN cord-317820-od9l7p1r 169 68 Who who WP cord-317820-od9l7p1r 169 69 Received receive VBD cord-317820-od9l7p1r 169 70 Ruxolitinib Ruxolitinib NNP cord-317820-od9l7p1r 169 71 Calcineurin Calcineurin NNP cord-317820-od9l7p1r 169 72 Inhibitors Inhibitors NNP cord-317820-od9l7p1r 169 73 Replacement Replacement NNP cord-317820-od9l7p1r 169 74 by by IN cord-317820-od9l7p1r 169 75 Ruxolitinib Ruxolitinib NNP cord-317820-od9l7p1r 169 76 as as IN cord-317820-od9l7p1r 169 77 Graft graft NN cord-317820-od9l7p1r 169 78 - - HYPH cord-317820-od9l7p1r 169 79 versus versus IN cord-317820-od9l7p1r 169 80 - - HYPH cord-317820-od9l7p1r 169 81 Host host NN cord-317820-od9l7p1r 169 82 Disease Disease NNP cord-317820-od9l7p1r 169 83 Prophylaxis Prophylaxis NNP cord-317820-od9l7p1r 169 84 for for IN cord-317820-od9l7p1r 169 85 Patients patient NNS cord-317820-od9l7p1r 169 86 after after IN cord-317820-od9l7p1r 169 87 The the DT cord-317820-od9l7p1r 169 88 authors author NNS cord-317820-od9l7p1r 169 89 declare declare VBP cord-317820-od9l7p1r 169 90 that that IN cord-317820-od9l7p1r 169 91 they -PRON- PRP cord-317820-od9l7p1r 169 92 have have VBP cord-317820-od9l7p1r 169 93 no no DT cord-317820-od9l7p1r 169 94 known know VBN cord-317820-od9l7p1r 169 95 competing compete VBG cord-317820-od9l7p1r 169 96 financial financial JJ cord-317820-od9l7p1r 169 97 interests interest NNS cord-317820-od9l7p1r 169 98 or or CC cord-317820-od9l7p1r 169 99 personal personal JJ cord-317820-od9l7p1r 169 100 relationships relationship NNS cord-317820-od9l7p1r 169 101 that that WDT cord-317820-od9l7p1r 169 102 could could MD cord-317820-od9l7p1r 169 103 have have VB cord-317820-od9l7p1r 169 104 appeared appear VBN cord-317820-od9l7p1r 169 105 to to TO cord-317820-od9l7p1r 169 106 influence influence VB cord-317820-od9l7p1r 169 107 the the DT cord-317820-od9l7p1r 169 108 work work NN cord-317820-od9l7p1r 169 109 reported report VBN cord-317820-od9l7p1r 169 110 in in IN cord-317820-od9l7p1r 169 111 this this DT cord-317820-od9l7p1r 169 112 paper paper NN cord-317820-od9l7p1r 170 1 None none NN cord-317820-od9l7p1r 170 2 . . . cord-317820-od9l7p1r 171 1 TNF TNF NNP cord-317820-od9l7p1r 171 2 Elevated elevated JJ cord-317820-od9l7p1r 171 3 blood blood NN cord-317820-od9l7p1r 171 4 level level NN cord-317820-od9l7p1r 171 5 in in IN cord-317820-od9l7p1r 171 6 severe severe JJ cord-317820-od9l7p1r 171 7 patients patient NNS cord-317820-od9l7p1r 171 8 [ [ -LRB- cord-317820-od9l7p1r 171 9 11 11 CD cord-317820-od9l7p1r 171 10 , , , cord-317820-od9l7p1r 171 11 15 15 CD cord-317820-od9l7p1r 171 12 , , , cord-317820-od9l7p1r 171 13 32 32 CD cord-317820-od9l7p1r 171 14 ] ] -RRB- cord-317820-od9l7p1r 171 15 Reduces reduce VBZ cord-317820-od9l7p1r 171 16 the the DT cord-317820-od9l7p1r 171 17 expression expression NN cord-317820-od9l7p1r 171 18 in in IN cord-317820-od9l7p1r 171 19 mast mast NN cord-317820-od9l7p1r 171 20 cells[101 cells[101 NNP cord-317820-od9l7p1r 171 21 ] ] -RRB-