id sid tid token lemma pos cord-315656-asvf4roo 1 1 key key JJ cord-315656-asvf4roo 2 1 : : : cord-315656-asvf4roo 2 2 cord-315656-asvf4roo cord-315656-asvf4roo JJ cord-315656-asvf4roo 2 3 authors author NNS cord-315656-asvf4roo 2 4 : : : cord-315656-asvf4roo 2 5 Wu Wu NNP cord-315656-asvf4roo 2 6 , , , cord-315656-asvf4roo 2 7 Junjiao Junjiao NNP cord-315656-asvf4roo 2 8 ; ; : cord-315656-asvf4roo 2 9 Tang Tang NNP cord-315656-asvf4roo 2 10 , , , cord-315656-asvf4roo 3 1 Yu Yu NNP cord-315656-asvf4roo 3 2 title title NN cord-315656-asvf4roo 3 3 : : : cord-315656-asvf4roo 3 4 Revisiting revisit VBG cord-315656-asvf4roo 3 5 the the DT cord-315656-asvf4roo 3 6 Immune Immune NNP cord-315656-asvf4roo 3 7 Balance Balance NNP cord-315656-asvf4roo 3 8 Theory theory NN cord-315656-asvf4roo 3 9 : : : cord-315656-asvf4roo 4 1 A a DT cord-315656-asvf4roo 4 2 Neurological Neurological NNP cord-315656-asvf4roo 4 3 Insight insight NN cord-315656-asvf4roo 4 4 Into into IN cord-315656-asvf4roo 4 5 the the DT cord-315656-asvf4roo 4 6 Epidemic epidemic NN cord-315656-asvf4roo 4 7 of of IN cord-315656-asvf4roo 4 8 COVID-19 COVID-19 NNP cord-315656-asvf4roo 4 9 and and CC cord-315656-asvf4roo 4 10 Its -PRON- PRP$ cord-315656-asvf4roo 4 11 Alike Alike NNP cord-315656-asvf4roo 4 12 date date NN cord-315656-asvf4roo 4 13 : : : cord-315656-asvf4roo 5 1 2020 2020 CD cord-315656-asvf4roo 5 2 - - SYM cord-315656-asvf4roo 5 3 10 10 CD cord-315656-asvf4roo 5 4 - - SYM cord-315656-asvf4roo 5 5 15 15 CD cord-315656-asvf4roo 5 6 journal journal NN cord-315656-asvf4roo 5 7 : : : cord-315656-asvf4roo 6 1 Front front JJ cord-315656-asvf4roo 6 2 Neurol neurol NN cord-315656-asvf4roo 6 3 DOI doi NN cord-315656-asvf4roo 6 4 : : : cord-315656-asvf4roo 6 5 10.3389 10.3389 CD cord-315656-asvf4roo 7 1 /fneur.2020.566680 /fneur.2020.566680 NFP cord-315656-asvf4roo 7 2 sha sha NNP cord-315656-asvf4roo 7 3 : : : cord-315656-asvf4roo 8 1 999e4561218448e067a4979a16aff014264f0219 999e4561218448e067a4979a16aff014264f0219 NNS cord-315656-asvf4roo 8 2 doc_id doc_id CD cord-315656-asvf4roo 8 3 : : : cord-315656-asvf4roo 8 4 315656 315656 CD cord-315656-asvf4roo 8 5 cord_uid cord_uid NNS cord-315656-asvf4roo 8 6 : : : cord-315656-asvf4roo 8 7 asvf4roo asvf4roo NNP cord-315656-asvf4roo 9 1 As as IN cord-315656-asvf4roo 9 2 the the DT cord-315656-asvf4roo 9 3 pandemic pandemic NN cord-315656-asvf4roo 9 4 of of IN cord-315656-asvf4roo 9 5 COVID-19 COVID-19 NNP cord-315656-asvf4roo 9 6 is be VBZ cord-315656-asvf4roo 9 7 raging rage VBG cord-315656-asvf4roo 9 8 around around IN cord-315656-asvf4roo 9 9 the the DT cord-315656-asvf4roo 9 10 world world NN cord-315656-asvf4roo 9 11 , , , cord-315656-asvf4roo 9 12 the the DT cord-315656-asvf4roo 9 13 mysteriousness mysteriousness NN cord-315656-asvf4roo 9 14 of of IN cord-315656-asvf4roo 9 15 severe severe JJ cord-315656-asvf4roo 9 16 acute acute JJ cord-315656-asvf4roo 9 17 respiratory respiratory JJ cord-315656-asvf4roo 9 18 syndrome syndrome NN cord-315656-asvf4roo 9 19 - - HYPH cord-315656-asvf4roo 9 20 coronavirus coronavirus NN cord-315656-asvf4roo 9 21 2 2 CD cord-315656-asvf4roo 10 1 ( ( -LRB- cord-315656-asvf4roo 10 2 SARS SARS NNP cord-315656-asvf4roo 10 3 - - HYPH cord-315656-asvf4roo 10 4 CoV-2 CoV-2 NNP cord-315656-asvf4roo 10 5 ) ) -RRB- cord-315656-asvf4roo 10 6 coronavirus coronavirus NN cord-315656-asvf4roo 10 7 is be VBZ cord-315656-asvf4roo 10 8 being be VBG cord-315656-asvf4roo 10 9 revealed reveal VBN cord-315656-asvf4roo 10 10 by by IN cord-315656-asvf4roo 10 11 the the DT cord-315656-asvf4roo 10 12 concerted concerted JJ cord-315656-asvf4roo 10 13 endeavors endeavor NNS cord-315656-asvf4roo 10 14 of of IN cord-315656-asvf4roo 10 15 scientists scientist NNS cord-315656-asvf4roo 10 16 . . . cord-315656-asvf4roo 11 1 Although although IN cord-315656-asvf4roo 11 2 fever fever NN cord-315656-asvf4roo 11 3 and and CC cord-315656-asvf4roo 11 4 pneumonia pneumonia NN cord-315656-asvf4roo 11 5 are be VBP cord-315656-asvf4roo 11 6 typical typical JJ cord-315656-asvf4roo 11 7 symptoms symptom NNS cord-315656-asvf4roo 11 8 , , , cord-315656-asvf4roo 11 9 COVID-19 COVID-19 NNP cord-315656-asvf4roo 11 10 patients patient NNS cord-315656-asvf4roo 11 11 exhibit exhibit VBP cord-315656-asvf4roo 11 12 multiple multiple JJ cord-315656-asvf4roo 11 13 neurological neurological JJ cord-315656-asvf4roo 11 14 complications complication NNS cord-315656-asvf4roo 11 15 . . . cord-315656-asvf4roo 12 1 In in IN cord-315656-asvf4roo 12 2 this this DT cord-315656-asvf4roo 12 3 interim interim JJ cord-315656-asvf4roo 12 4 review review NN cord-315656-asvf4roo 12 5 , , , cord-315656-asvf4roo 12 6 we -PRON- PRP cord-315656-asvf4roo 12 7 will will MD cord-315656-asvf4roo 12 8 summarize summarize VB cord-315656-asvf4roo 12 9 the the DT cord-315656-asvf4roo 12 10 neurological neurological JJ cord-315656-asvf4roo 12 11 manifestations manifestation NNS cord-315656-asvf4roo 12 12 and and CC cord-315656-asvf4roo 12 13 their -PRON- PRP$ cord-315656-asvf4roo 12 14 potential potential JJ cord-315656-asvf4roo 12 15 causes cause NNS cord-315656-asvf4roo 12 16 in in IN cord-315656-asvf4roo 12 17 COVID-19 COVID-19 NNP cord-315656-asvf4roo 12 18 . . . cord-315656-asvf4roo 13 1 Similar similar JJ cord-315656-asvf4roo 13 2 to to IN cord-315656-asvf4roo 13 3 the the DT cord-315656-asvf4roo 13 4 other other JJ cord-315656-asvf4roo 13 5 two two CD cord-315656-asvf4roo 13 6 fatal fatal JJ cord-315656-asvf4roo 13 7 respiratory respiratory JJ cord-315656-asvf4roo 13 8 coronaviruses coronaviruse NNS cord-315656-asvf4roo 13 9 , , , cord-315656-asvf4roo 13 10 SARS SARS NNP cord-315656-asvf4roo 13 11 - - HYPH cord-315656-asvf4roo 13 12 CoV CoV NNP cord-315656-asvf4roo 13 13 and and CC cord-315656-asvf4roo 13 14 Middle Middle NNP cord-315656-asvf4roo 13 15 East East NNP cord-315656-asvf4roo 13 16 respiratory respiratory JJ cord-315656-asvf4roo 13 17 syndrome syndrome NN cord-315656-asvf4roo 13 18 coronavirus coronavirus NN cord-315656-asvf4roo 13 19 ( ( -LRB- cord-315656-asvf4roo 13 20 MERS MERS NNP cord-315656-asvf4roo 13 21 - - HYPH cord-315656-asvf4roo 13 22 CoV CoV NNP cord-315656-asvf4roo 13 23 ) ) -RRB- cord-315656-asvf4roo 13 24 , , , cord-315656-asvf4roo 13 25 SARS SARS NNP cord-315656-asvf4roo 13 26 - - HYPH cord-315656-asvf4roo 13 27 CoV-2 CoV-2 NNP cord-315656-asvf4roo 13 28 also also RB cord-315656-asvf4roo 13 29 shows show VBZ cord-315656-asvf4roo 13 30 to to TO cord-315656-asvf4roo 13 31 be be VB cord-315656-asvf4roo 13 32 neuroinvasive neuroinvasive JJ cord-315656-asvf4roo 13 33 that that WDT cord-315656-asvf4roo 13 34 may may MD cord-315656-asvf4roo 13 35 spread spread VB cord-315656-asvf4roo 13 36 from from IN cord-315656-asvf4roo 13 37 the the DT cord-315656-asvf4roo 13 38 periphery periphery NN cord-315656-asvf4roo 13 39 to to IN cord-315656-asvf4roo 13 40 brain brain NN cord-315656-asvf4roo 13 41 , , , cord-315656-asvf4roo 13 42 probably probably RB cord-315656-asvf4roo 13 43 by by IN cord-315656-asvf4roo 13 44 the the DT cord-315656-asvf4roo 13 45 retrograde retrograde JJ cord-315656-asvf4roo 13 46 axonal axonal JJ cord-315656-asvf4roo 13 47 transport transport NN cord-315656-asvf4roo 13 48 . . . cord-315656-asvf4roo 14 1 The the DT cord-315656-asvf4roo 14 2 invaded invade VBN cord-315656-asvf4roo 14 3 viruses virus NNS cord-315656-asvf4roo 14 4 may may MD cord-315656-asvf4roo 14 5 directly directly RB cord-315656-asvf4roo 14 6 disrupt disrupt VB cord-315656-asvf4roo 14 7 the the DT cord-315656-asvf4roo 14 8 complex complex JJ cord-315656-asvf4roo 14 9 neural neural JJ cord-315656-asvf4roo 14 10 circuits circuit NNS cord-315656-asvf4roo 14 11 , , , cord-315656-asvf4roo 14 12 and and CC cord-315656-asvf4roo 14 13 raise raise VB cord-315656-asvf4roo 14 14 a a DT cord-315656-asvf4roo 14 15 chronic chronic JJ cord-315656-asvf4roo 14 16 activation activation NN cord-315656-asvf4roo 14 17 of of IN cord-315656-asvf4roo 14 18 immune immune JJ cord-315656-asvf4roo 14 19 responses response NNS cord-315656-asvf4roo 14 20 . . . cord-315656-asvf4roo 15 1 In in IN cord-315656-asvf4roo 15 2 another another DT cord-315656-asvf4roo 15 3 hand hand NN cord-315656-asvf4roo 15 4 , , , cord-315656-asvf4roo 15 5 multiple multiple JJ cord-315656-asvf4roo 15 6 organ organ NN cord-315656-asvf4roo 15 7 failure failure NN cord-315656-asvf4roo 15 8 in in IN cord-315656-asvf4roo 15 9 severe severe JJ cord-315656-asvf4roo 15 10 COVID-19 covid-19 NN cord-315656-asvf4roo 15 11 is be VBZ cord-315656-asvf4roo 15 12 caused cause VBN cord-315656-asvf4roo 15 13 by by IN cord-315656-asvf4roo 15 14 the the DT cord-315656-asvf4roo 15 15 systemic systemic JJ cord-315656-asvf4roo 15 16 acute acute JJ cord-315656-asvf4roo 15 17 immune immune JJ cord-315656-asvf4roo 15 18 responses response NNS cord-315656-asvf4roo 15 19 , , , cord-315656-asvf4roo 15 20 and and CC cord-315656-asvf4roo 15 21 unsurprisingly unsurprisingly RB cord-315656-asvf4roo 15 22 caused cause VBD cord-315656-asvf4roo 15 23 the the DT cord-315656-asvf4roo 15 24 brain brain NN cord-315656-asvf4roo 15 25 inflammation inflammation NN cord-315656-asvf4roo 15 26 and and CC cord-315656-asvf4roo 15 27 led lead VBD cord-315656-asvf4roo 15 28 to to IN cord-315656-asvf4roo 15 29 encephalitis encephalitis NN cord-315656-asvf4roo 15 30 . . . cord-315656-asvf4roo 16 1 However however RB cord-315656-asvf4roo 16 2 , , , cord-315656-asvf4roo 16 3 in in IN cord-315656-asvf4roo 16 4 the the DT cord-315656-asvf4roo 16 5 central central JJ cord-315656-asvf4roo 16 6 nervous nervous JJ cord-315656-asvf4roo 16 7 system system NN cord-315656-asvf4roo 16 8 ( ( -LRB- cord-315656-asvf4roo 16 9 CNS CNS NNP cord-315656-asvf4roo 16 10 ) ) -RRB- cord-315656-asvf4roo 16 11 , , , cord-315656-asvf4roo 16 12 the the DT cord-315656-asvf4roo 16 13 activation activation NN cord-315656-asvf4roo 16 14 of of IN cord-315656-asvf4roo 16 15 resident resident JJ cord-315656-asvf4roo 16 16 immune immune JJ cord-315656-asvf4roo 16 17 cells cell NNS cord-315656-asvf4roo 16 18 including include VBG cord-315656-asvf4roo 16 19 microglia microglia NNS cord-315656-asvf4roo 16 20 and and CC cord-315656-asvf4roo 16 21 astrocytes astrocyte NNS cord-315656-asvf4roo 16 22 may may MD cord-315656-asvf4roo 16 23 lead lead VB cord-315656-asvf4roo 16 24 to to IN cord-315656-asvf4roo 16 25 chronic chronic JJ cord-315656-asvf4roo 16 26 immune immune JJ cord-315656-asvf4roo 16 27 imbalance imbalance NN cord-315656-asvf4roo 16 28 , , , cord-315656-asvf4roo 16 29 which which WDT cord-315656-asvf4roo 16 30 underlies underlie VBZ cord-315656-asvf4roo 16 31 the the DT cord-315656-asvf4roo 16 32 potential potential JJ cord-315656-asvf4roo 16 33 long long JJ cord-315656-asvf4roo 16 34 - - HYPH cord-315656-asvf4roo 16 35 term term NN cord-315656-asvf4roo 16 36 effects effect NNS cord-315656-asvf4roo 16 37 in in IN cord-315656-asvf4roo 16 38 synaptic synaptic JJ cord-315656-asvf4roo 16 39 changes change NNS cord-315656-asvf4roo 16 40 and and CC cord-315656-asvf4roo 16 41 neuropsychiatric neuropsychiatric JJ cord-315656-asvf4roo 16 42 impairments impairment NNS cord-315656-asvf4roo 16 43 . . . cord-315656-asvf4roo 17 1 The the DT cord-315656-asvf4roo 17 2 neuroinvasive neuroinvasive JJ cord-315656-asvf4roo 17 3 biology biology NN cord-315656-asvf4roo 17 4 also also RB cord-315656-asvf4roo 17 5 provides provide VBZ cord-315656-asvf4roo 17 6 a a DT cord-315656-asvf4roo 17 7 possible possible JJ cord-315656-asvf4roo 17 8 link link NN cord-315656-asvf4roo 17 9 with with IN cord-315656-asvf4roo 17 10 the the DT cord-315656-asvf4roo 17 11 Braak Braak NNP cord-315656-asvf4roo 17 12 staging staging NN cord-315656-asvf4roo 17 13 of of IN cord-315656-asvf4roo 17 14 neurodegenerative neurodegenerative JJ cord-315656-asvf4roo 17 15 diseases disease NNS cord-315656-asvf4roo 17 16 such such JJ cord-315656-asvf4roo 17 17 as as IN cord-315656-asvf4roo 17 18 Parkinson Parkinson NNP cord-315656-asvf4roo 17 19 's 's POS cord-315656-asvf4roo 17 20 disease disease NN cord-315656-asvf4roo 17 21 ( ( -LRB- cord-315656-asvf4roo 17 22 PD PD NNP cord-315656-asvf4roo 17 23 ) ) -RRB- cord-315656-asvf4roo 17 24 . . . cord-315656-asvf4roo 18 1 Although although IN cord-315656-asvf4roo 18 2 with with IN cord-315656-asvf4roo 18 3 considerable considerable JJ cord-315656-asvf4roo 18 4 advances advance NNS cord-315656-asvf4roo 18 5 , , , cord-315656-asvf4roo 18 6 the the DT cord-315656-asvf4roo 18 7 neurotropic neurotropic NNP cord-315656-asvf4roo 18 8 potential potential NN cord-315656-asvf4roo 18 9 and and CC cord-315656-asvf4roo 18 10 chronic chronic JJ cord-315656-asvf4roo 18 11 neurological neurological JJ cord-315656-asvf4roo 18 12 effects effect NNS cord-315656-asvf4roo 18 13 caused cause VBN cord-315656-asvf4roo 18 14 by by IN cord-315656-asvf4roo 18 15 SARS SARS NNP cord-315656-asvf4roo 18 16 - - HYPH cord-315656-asvf4roo 18 17 CoV-2 CoV-2 NNP cord-315656-asvf4roo 18 18 infections infection NNS cord-315656-asvf4roo 18 19 merit merit VBP cord-315656-asvf4roo 18 20 further further JJ cord-315656-asvf4roo 18 21 investigations investigation NNS cord-315656-asvf4roo 18 22 . . . cord-315656-asvf4roo 19 1 The the DT cord-315656-asvf4roo 19 2 ongoing ongoing JJ cord-315656-asvf4roo 19 3 spread spread NN cord-315656-asvf4roo 19 4 of of IN cord-315656-asvf4roo 19 5 COVID-19 COVID-19 NNP cord-315656-asvf4roo 19 6 disease disease NN cord-315656-asvf4roo 19 7 , , , cord-315656-asvf4roo 19 8 is be VBZ cord-315656-asvf4roo 19 9 the the DT cord-315656-asvf4roo 19 10 first first JJ cord-315656-asvf4roo 19 11 pandemic pandemic NN cord-315656-asvf4roo 19 12 ever ever RB cord-315656-asvf4roo 19 13 caused cause VBN cord-315656-asvf4roo 19 14 by by IN cord-315656-asvf4roo 19 15 coronaviruses coronaviruse NNS cord-315656-asvf4roo 19 16 in in IN cord-315656-asvf4roo 19 17 the the DT cord-315656-asvf4roo 19 18 human human JJ cord-315656-asvf4roo 19 19 history history NN cord-315656-asvf4roo 19 20 , , , cord-315656-asvf4roo 19 21 as as IN cord-315656-asvf4roo 19 22 announced announce VBN cord-315656-asvf4roo 19 23 by by IN cord-315656-asvf4roo 19 24 the the DT cord-315656-asvf4roo 19 25 World World NNP cord-315656-asvf4roo 19 26 Health Health NNP cord-315656-asvf4roo 19 27 Organization Organization NNP cord-315656-asvf4roo 19 28 ( ( -LRB- cord-315656-asvf4roo 19 29 WHO who WP cord-315656-asvf4roo 19 30 ) ) -RRB- cord-315656-asvf4roo 19 31 in in IN cord-315656-asvf4roo 19 32 March March NNP cord-315656-asvf4roo 19 33 2020 2020 CD cord-315656-asvf4roo 19 34 . . . cord-315656-asvf4roo 20 1 The the DT cord-315656-asvf4roo 20 2 ferocious ferocious JJ cord-315656-asvf4roo 20 3 virus virus NN cord-315656-asvf4roo 20 4 , , , cord-315656-asvf4roo 20 5 isolated isolate VBN cord-315656-asvf4roo 20 6 as as IN cord-315656-asvf4roo 20 7 a a DT cord-315656-asvf4roo 20 8 new new JJ cord-315656-asvf4roo 20 9 strain strain NN cord-315656-asvf4roo 20 10 of of IN cord-315656-asvf4roo 20 11 zoonotic zoonotic JJ cord-315656-asvf4roo 20 12 coronavirus coronavirus NN cord-315656-asvf4roo 20 13 named name VBN cord-315656-asvf4roo 20 14 as as IN cord-315656-asvf4roo 20 15 severe severe JJ cord-315656-asvf4roo 20 16 acute acute JJ cord-315656-asvf4roo 20 17 respiratory respiratory JJ cord-315656-asvf4roo 20 18 syndrome syndrome NN cord-315656-asvf4roo 20 19 - - HYPH cord-315656-asvf4roo 20 20 coronavirus coronavirus NN cord-315656-asvf4roo 20 21 2 2 CD cord-315656-asvf4roo 20 22 ( ( -LRB- cord-315656-asvf4roo 20 23 SARS SARS NNP cord-315656-asvf4roo 20 24 - - HYPH cord-315656-asvf4roo 20 25 CoV-2 CoV-2 NNP cord-315656-asvf4roo 20 26 ) ) -RRB- cord-315656-asvf4roo 20 27 , , , cord-315656-asvf4roo 20 28 has have VBZ cord-315656-asvf4roo 20 29 rapidly rapidly RB cord-315656-asvf4roo 20 30 spread spread VBN cord-315656-asvf4roo 20 31 with with IN cord-315656-asvf4roo 20 32 over over IN cord-315656-asvf4roo 20 33 23.2 23.2 CD cord-315656-asvf4roo 20 34 million million CD cord-315656-asvf4roo 20 35 confirmed confirm VBN cord-315656-asvf4roo 20 36 cases case NNS cord-315656-asvf4roo 20 37 and and CC cord-315656-asvf4roo 20 38 0.8 0.8 CD cord-315656-asvf4roo 20 39 million million CD cord-315656-asvf4roo 20 40 deaths death NNS cord-315656-asvf4roo 20 41 globally globally RB cord-315656-asvf4roo 20 42 as as IN cord-315656-asvf4roo 20 43 of of IN cord-315656-asvf4roo 20 44 Aug Aug NNP cord-315656-asvf4roo 20 45 23 23 CD cord-315656-asvf4roo 20 46 2020 2020 CD cord-315656-asvf4roo 21 1 ( ( -LRB- cord-315656-asvf4roo 21 2 Johns Johns NNP cord-315656-asvf4roo 21 3 Hopkins Hopkins NNP cord-315656-asvf4roo 21 4 University University NNP cord-315656-asvf4roo 21 5 ) ) -RRB- cord-315656-asvf4roo 21 6 . . . cord-315656-asvf4roo 22 1 The the DT cord-315656-asvf4roo 22 2 pandemic pandemic NN cord-315656-asvf4roo 22 3 has have VBZ cord-315656-asvf4roo 22 4 exhausted exhaust VBN cord-315656-asvf4roo 22 5 the the DT cord-315656-asvf4roo 22 6 entire entire JJ cord-315656-asvf4roo 22 7 worlds world NNS cord-315656-asvf4roo 22 8 ' ' POS cord-315656-asvf4roo 22 9 personal personal JJ cord-315656-asvf4roo 22 10 protective protective JJ cord-315656-asvf4roo 22 11 equipment equipment NN cord-315656-asvf4roo 22 12 and and CC cord-315656-asvf4roo 22 13 medical medical JJ cord-315656-asvf4roo 22 14 ventilators ventilator NNS cord-315656-asvf4roo 22 15 , , , cord-315656-asvf4roo 22 16 and and CC cord-315656-asvf4roo 22 17 is be VBZ cord-315656-asvf4roo 22 18 also also RB cord-315656-asvf4roo 22 19 strenuously strenuously RB cord-315656-asvf4roo 22 20 hurting hurt VBG cord-315656-asvf4roo 22 21 the the DT cord-315656-asvf4roo 22 22 global global JJ cord-315656-asvf4roo 22 23 economy economy NN cord-315656-asvf4roo 22 24 and and CC cord-315656-asvf4roo 22 25 raising raise VBG cord-315656-asvf4roo 22 26 considerable considerable JJ cord-315656-asvf4roo 22 27 social social JJ cord-315656-asvf4roo 22 28 issues issue NNS cord-315656-asvf4roo 22 29 . . . cord-315656-asvf4roo 23 1 As as IN cord-315656-asvf4roo 23 2 we -PRON- PRP cord-315656-asvf4roo 23 3 are be VBP cord-315656-asvf4roo 23 4 in in IN cord-315656-asvf4roo 23 5 the the DT cord-315656-asvf4roo 23 6 midst midst NN cord-315656-asvf4roo 23 7 of of IN cord-315656-asvf4roo 23 8 this this DT cord-315656-asvf4roo 23 9 ongoing ongoing JJ cord-315656-asvf4roo 23 10 pandemic pandemic NN cord-315656-asvf4roo 23 11 , , , cord-315656-asvf4roo 23 12 it -PRON- PRP cord-315656-asvf4roo 23 13 has have VBZ cord-315656-asvf4roo 23 14 gathered gather VBN cord-315656-asvf4roo 23 15 the the DT cord-315656-asvf4roo 23 16 concerted concerted JJ cord-315656-asvf4roo 23 17 efforts effort NNS cord-315656-asvf4roo 23 18 of of IN cord-315656-asvf4roo 23 19 clinicians clinician NNS cord-315656-asvf4roo 23 20 , , , cord-315656-asvf4roo 23 21 public public JJ cord-315656-asvf4roo 23 22 health health NN cord-315656-asvf4roo 23 23 experts expert NNS cord-315656-asvf4roo 23 24 , , , cord-315656-asvf4roo 23 25 virologists virologist NNS cord-315656-asvf4roo 23 26 , , , cord-315656-asvf4roo 23 27 immunologists immunologist NNS cord-315656-asvf4roo 23 28 , , , cord-315656-asvf4roo 23 29 and and CC cord-315656-asvf4roo 23 30 other other JJ cord-315656-asvf4roo 23 31 scientists scientist NNS cord-315656-asvf4roo 23 32 to to TO cord-315656-asvf4roo 23 33 understand understand VB cord-315656-asvf4roo 23 34 the the DT cord-315656-asvf4roo 23 35 virus virus NN cord-315656-asvf4roo 23 36 's 's POS cord-315656-asvf4roo 23 37 biology biology NN cord-315656-asvf4roo 23 38 and and CC cord-315656-asvf4roo 23 39 blocking block VBG cord-315656-asvf4roo 23 40 agents agent NNS cord-315656-asvf4roo 23 41 . . . cord-315656-asvf4roo 24 1 So so RB cord-315656-asvf4roo 24 2 far far RB cord-315656-asvf4roo 24 3 , , , cord-315656-asvf4roo 24 4 a a DT cord-315656-asvf4roo 24 5 myriad myriad NN cord-315656-asvf4roo 24 6 of of IN cord-315656-asvf4roo 24 7 urgent urgent JJ cord-315656-asvf4roo 24 8 endeavors endeavor NNS cord-315656-asvf4roo 24 9 has have VBZ cord-315656-asvf4roo 24 10 been be VBN cord-315656-asvf4roo 24 11 maneuvered maneuver VBN cord-315656-asvf4roo 24 12 , , , cord-315656-asvf4roo 24 13 aiming aim VBG cord-315656-asvf4roo 24 14 to to TO cord-315656-asvf4roo 24 15 reveal reveal VB cord-315656-asvf4roo 24 16 the the DT cord-315656-asvf4roo 24 17 multiple multiple JJ cord-315656-asvf4roo 24 18 aspects aspect NNS cord-315656-asvf4roo 24 19 of of IN cord-315656-asvf4roo 24 20 this this DT cord-315656-asvf4roo 24 21 wily wily JJ cord-315656-asvf4roo 24 22 virus virus NN cord-315656-asvf4roo 24 23 , , , cord-315656-asvf4roo 24 24 ranging range VBG cord-315656-asvf4roo 24 25 from from IN cord-315656-asvf4roo 24 26 the the DT cord-315656-asvf4roo 24 27 genomic genomic JJ cord-315656-asvf4roo 24 28 structures structure NNS cord-315656-asvf4roo 24 29 , , , cord-315656-asvf4roo 24 30 sensing sense VBG cord-315656-asvf4roo 24 31 receptors receptor NNS cord-315656-asvf4roo 24 32 to to IN cord-315656-asvf4roo 24 33 the the DT cord-315656-asvf4roo 24 34 development development NN cord-315656-asvf4roo 24 35 of of IN cord-315656-asvf4roo 24 36 specific specific JJ cord-315656-asvf4roo 24 37 medicines medicine NNS cord-315656-asvf4roo 24 38 and and CC cord-315656-asvf4roo 24 39 vaccines vaccine NNS cord-315656-asvf4roo 24 40 . . . cord-315656-asvf4roo 25 1 Structurally structurally RB cord-315656-asvf4roo 25 2 , , , cord-315656-asvf4roo 25 3 SARS SARS NNP cord-315656-asvf4roo 25 4 - - HYPH cord-315656-asvf4roo 25 5 CoV-2 CoV-2 NNP cord-315656-asvf4roo 25 6 is be VBZ cord-315656-asvf4roo 25 7 a a DT cord-315656-asvf4roo 25 8 single single JJ cord-315656-asvf4roo 25 9 - - HYPH cord-315656-asvf4roo 25 10 stranded strand VBN cord-315656-asvf4roo 25 11 RNA RNA NNP cord-315656-asvf4roo 25 12 virus virus NN cord-315656-asvf4roo 25 13 , , , cord-315656-asvf4roo 25 14 whose whose WP$ cord-315656-asvf4roo 25 15 genome genome NN cord-315656-asvf4roo 25 16 contains contain VBZ cord-315656-asvf4roo 25 17 29,891 29,891 CD cord-315656-asvf4roo 25 18 nucleotides nucleotide NNS cord-315656-asvf4roo 25 19 in in IN cord-315656-asvf4roo 25 20 size size NN cord-315656-asvf4roo 25 21 and and CC cord-315656-asvf4roo 25 22 12 12 CD cord-315656-asvf4roo 25 23 putative putative JJ cord-315656-asvf4roo 25 24 functional functional JJ cord-315656-asvf4roo 25 25 open open JJ cord-315656-asvf4roo 25 26 reading reading NN cord-315656-asvf4roo 25 27 frames frame NNS cord-315656-asvf4roo 25 28 ( ( -LRB- cord-315656-asvf4roo 25 29 ORFs ORFs NNP cord-315656-asvf4roo 25 30 ) ) -RRB- cord-315656-asvf4roo 25 31 ( ( -LRB- cord-315656-asvf4roo 25 32 1 1 CD cord-315656-asvf4roo 25 33 ) ) -RRB- cord-315656-asvf4roo 25 34 . . . cord-315656-asvf4roo 26 1 Of of IN cord-315656-asvf4roo 26 2 those those DT cord-315656-asvf4roo 26 3 translated translate VBN cord-315656-asvf4roo 26 4 proteins protein NNS cord-315656-asvf4roo 26 5 , , , cord-315656-asvf4roo 26 6 the the DT cord-315656-asvf4roo 26 7 spike spike NN cord-315656-asvf4roo 26 8 proteins protein NNS cord-315656-asvf4roo 26 9 located locate VBN cord-315656-asvf4roo 26 10 on on IN cord-315656-asvf4roo 26 11 the the DT cord-315656-asvf4roo 26 12 virus virus NN cord-315656-asvf4roo 26 13 surface surface NN cord-315656-asvf4roo 26 14 mediate mediate VB cord-315656-asvf4roo 26 15 the the DT cord-315656-asvf4roo 26 16 virus virus NN cord-315656-asvf4roo 26 17 entry entry NN cord-315656-asvf4roo 26 18 into into IN cord-315656-asvf4roo 26 19 host host NN cord-315656-asvf4roo 26 20 cells cell NNS cord-315656-asvf4roo 26 21 ( ( -LRB- cord-315656-asvf4roo 26 22 2 2 CD cord-315656-asvf4roo 26 23 , , , cord-315656-asvf4roo 26 24 3 3 CD cord-315656-asvf4roo 26 25 ) ) -RRB- cord-315656-asvf4roo 26 26 . . . cord-315656-asvf4roo 27 1 Mechanistically Mechanistically NNP cord-315656-asvf4roo 27 2 , , , cord-315656-asvf4roo 27 3 the the DT cord-315656-asvf4roo 27 4 spike spike NN cord-315656-asvf4roo 27 5 of of IN cord-315656-asvf4roo 27 6 SARS SARS NNP cord-315656-asvf4roo 27 7 - - HYPH cord-315656-asvf4roo 27 8 CoV-2 CoV-2 NNP cord-315656-asvf4roo 27 9 senses sense VBZ cord-315656-asvf4roo 27 10 the the DT cord-315656-asvf4roo 27 11 angiotensin angiotensin NN cord-315656-asvf4roo 27 12 converting convert VBG cord-315656-asvf4roo 27 13 enzyme enzyme NN cord-315656-asvf4roo 27 14 2 2 CD cord-315656-asvf4roo 27 15 ( ( -LRB- cord-315656-asvf4roo 27 16 ACE2 ACE2 NNP cord-315656-asvf4roo 27 17 ) ) -RRB- cord-315656-asvf4roo 27 18 receptor receptor NN cord-315656-asvf4roo 27 19 ( ( -LRB- cord-315656-asvf4roo 27 20 2 2 CD cord-315656-asvf4roo 27 21 ) ) -RRB- cord-315656-asvf4roo 27 22 ( ( -LRB- cord-315656-asvf4roo 27 23 3 3 LS cord-315656-asvf4roo 27 24 ) ) -RRB- cord-315656-asvf4roo 27 25 ( ( -LRB- cord-315656-asvf4roo 27 26 4 4 LS cord-315656-asvf4roo 27 27 ) ) -RRB- cord-315656-asvf4roo 28 1 ( ( -LRB- cord-315656-asvf4roo 28 2 5 5 LS cord-315656-asvf4roo 28 3 ) ) -RRB- cord-315656-asvf4roo 28 4 , , , cord-315656-asvf4roo 28 5 the the DT cord-315656-asvf4roo 28 6 same same JJ cord-315656-asvf4roo 28 7 as as IN cord-315656-asvf4roo 28 8 SARS SARS NNP cord-315656-asvf4roo 28 9 - - HYPH cord-315656-asvf4roo 28 10 CoV CoV NNP cord-315656-asvf4roo 28 11 , , , cord-315656-asvf4roo 28 12 which which WDT cord-315656-asvf4roo 28 13 normally normally RB cord-315656-asvf4roo 28 14 helps help VBZ cord-315656-asvf4roo 28 15 regulate regulate VB cord-315656-asvf4roo 28 16 blood blood NN cord-315656-asvf4roo 28 17 pressure pressure NN cord-315656-asvf4roo 28 18 and and CC cord-315656-asvf4roo 28 19 anti anti JJ cord-315656-asvf4roo 28 20 - - JJ cord-315656-asvf4roo 28 21 atherosclerosis atherosclerosis JJ cord-315656-asvf4roo 28 22 ( ( -LRB- cord-315656-asvf4roo 28 23 6 6 CD cord-315656-asvf4roo 28 24 ) ) -RRB- cord-315656-asvf4roo 28 25 . . . cord-315656-asvf4roo 29 1 This this DT cord-315656-asvf4roo 29 2 binding binding NN cord-315656-asvf4roo 29 3 , , , cord-315656-asvf4roo 29 4 in in IN cord-315656-asvf4roo 29 5 concert concert NN cord-315656-asvf4roo 29 6 with with IN cord-315656-asvf4roo 29 7 host host NN cord-315656-asvf4roo 29 8 proteases protease NNS cord-315656-asvf4roo 29 9 , , , cord-315656-asvf4roo 29 10 principally principally RB cord-315656-asvf4roo 29 11 TMPRSS2 TMPRSS2 NNP cord-315656-asvf4roo 29 12 , , , cord-315656-asvf4roo 29 13 facilitates facilitate VBZ cord-315656-asvf4roo 29 14 the the DT cord-315656-asvf4roo 29 15 virus virus NN cord-315656-asvf4roo 29 16 getting get VBG cord-315656-asvf4roo 29 17 through through IN cord-315656-asvf4roo 29 18 the the DT cord-315656-asvf4roo 29 19 cell cell NN cord-315656-asvf4roo 29 20 membrane membrane NN cord-315656-asvf4roo 29 21 by by IN cord-315656-asvf4roo 29 22 endocytosis endocytosis NN cord-315656-asvf4roo 29 23 ( ( -LRB- cord-315656-asvf4roo 29 24 4 4 CD cord-315656-asvf4roo 29 25 ) ) -RRB- cord-315656-asvf4roo 29 26 , , , cord-315656-asvf4roo 29 27 followed follow VBN cord-315656-asvf4roo 29 28 by by IN cord-315656-asvf4roo 29 29 hijacking hijack VBG cord-315656-asvf4roo 29 30 the the DT cord-315656-asvf4roo 29 31 host host NN cord-315656-asvf4roo 29 32 cell cell NN cord-315656-asvf4roo 29 33 's 's POS cord-315656-asvf4roo 29 34 translation translation NN cord-315656-asvf4roo 29 35 machinery machinery NN cord-315656-asvf4roo 29 36 and and CC cord-315656-asvf4roo 29 37 producing produce VBG cord-315656-asvf4roo 29 38 massive massive JJ cord-315656-asvf4roo 29 39 virus virus NN cord-315656-asvf4roo 29 40 copies copy NNS cord-315656-asvf4roo 29 41 and and CC cord-315656-asvf4roo 29 42 further further RB cord-315656-asvf4roo 29 43 invading invade VBG cord-315656-asvf4roo 29 44 new new JJ cord-315656-asvf4roo 29 45 cells cell NNS cord-315656-asvf4roo 29 46 . . . cord-315656-asvf4roo 30 1 As as IN cord-315656-asvf4roo 30 2 ACE2 ACE2 NNP cord-315656-asvf4roo 30 3 is be VBZ cord-315656-asvf4roo 30 4 typically typically RB cord-315656-asvf4roo 30 5 enriched enrich VBN cord-315656-asvf4roo 30 6 in in IN cord-315656-asvf4roo 30 7 type type NN cord-315656-asvf4roo 30 8 II ii CD cord-315656-asvf4roo 30 9 alveoli alveolus NNS cord-315656-asvf4roo 30 10 cells cell NNS cord-315656-asvf4roo 30 11 , , , cord-315656-asvf4roo 30 12 the the DT cord-315656-asvf4roo 30 13 lung lung NN cord-315656-asvf4roo 30 14 tissue tissue NN cord-315656-asvf4roo 30 15 becomes become VBZ cord-315656-asvf4roo 30 16 the the DT cord-315656-asvf4roo 30 17 major major JJ cord-315656-asvf4roo 30 18 organ organ NN cord-315656-asvf4roo 30 19 affected affect VBN cord-315656-asvf4roo 30 20 by by IN cord-315656-asvf4roo 30 21 the the DT cord-315656-asvf4roo 30 22 virus virus NN cord-315656-asvf4roo 30 23 ( ( -LRB- cord-315656-asvf4roo 30 24 7 7 CD cord-315656-asvf4roo 30 25 ) ) -RRB- cord-315656-asvf4roo 30 26 . . . cord-315656-asvf4roo 31 1 The the DT cord-315656-asvf4roo 31 2 typical typical JJ cord-315656-asvf4roo 31 3 symptoms symptom NNS cord-315656-asvf4roo 31 4 of of IN cord-315656-asvf4roo 31 5 COVID-19 COVID-19 NNP cord-315656-asvf4roo 31 6 , , , cord-315656-asvf4roo 31 7 unsurprisingly unsurprisingly RB cord-315656-asvf4roo 31 8 , , , cord-315656-asvf4roo 31 9 are be VBP cord-315656-asvf4roo 31 10 fever fever NN cord-315656-asvf4roo 31 11 , , , cord-315656-asvf4roo 31 12 cough cough NN cord-315656-asvf4roo 31 13 , , , cord-315656-asvf4roo 31 14 and and CC cord-315656-asvf4roo 31 15 pneumonia pneumonia NN cord-315656-asvf4roo 31 16 , , , cord-315656-asvf4roo 31 17 which which WDT cord-315656-asvf4roo 31 18 probably probably RB cord-315656-asvf4roo 31 19 lead lead VBP cord-315656-asvf4roo 31 20 to to IN cord-315656-asvf4roo 31 21 acute acute JJ cord-315656-asvf4roo 31 22 respiratory respiratory JJ cord-315656-asvf4roo 31 23 distress distress NN cord-315656-asvf4roo 31 24 syndrome syndrome NN cord-315656-asvf4roo 31 25 ( ( -LRB- cord-315656-asvf4roo 31 26 ARDS ARDS NNP cord-315656-asvf4roo 31 27 ) ) -RRB- cord-315656-asvf4roo 31 28 and and CC cord-315656-asvf4roo 31 29 acute acute JJ cord-315656-asvf4roo 31 30 lung lung NN cord-315656-asvf4roo 31 31 injury injury NN cord-315656-asvf4roo 31 32 , , , cord-315656-asvf4roo 31 33 as as IN cord-315656-asvf4roo 31 34 described describe VBN cord-315656-asvf4roo 31 35 in in IN cord-315656-asvf4roo 31 36 around around RB cord-315656-asvf4roo 31 37 20 20 CD cord-315656-asvf4roo 31 38 % % NN cord-315656-asvf4roo 31 39 of of IN cord-315656-asvf4roo 31 40 COVID-19 covid-19 JJ cord-315656-asvf4roo 31 41 patients patient NNS cord-315656-asvf4roo 31 42 ( ( -LRB- cord-315656-asvf4roo 31 43 8) 8) NNP cord-315656-asvf4roo 31 44 . . . cord-315656-asvf4roo 32 1 Along along IN cord-315656-asvf4roo 32 2 with with IN cord-315656-asvf4roo 32 3 SARS SARS NNP cord-315656-asvf4roo 32 4 - - HYPH cord-315656-asvf4roo 32 5 CoV CoV NNP cord-315656-asvf4roo 32 6 broke break VBD cord-315656-asvf4roo 32 7 out out RP cord-315656-asvf4roo 32 8 in in IN cord-315656-asvf4roo 32 9 2003 2003 CD cord-315656-asvf4roo 32 10 and and CC cord-315656-asvf4roo 32 11 Middle Middle NNP cord-315656-asvf4roo 32 12 East East NNP cord-315656-asvf4roo 32 13 respiratory respiratory JJ cord-315656-asvf4roo 32 14 syndrome syndrome NN cord-315656-asvf4roo 32 15 coronavirus coronavirus NN cord-315656-asvf4roo 32 16 ( ( -LRB- cord-315656-asvf4roo 32 17 MERS MERS NNP cord-315656-asvf4roo 32 18 - - HYPH cord-315656-asvf4roo 32 19 CoV CoV NNP cord-315656-asvf4roo 32 20 ) ) -RRB- cord-315656-asvf4roo 32 21 since since IN cord-315656-asvf4roo 32 22 2012 2012 CD cord-315656-asvf4roo 32 23 , , , cord-315656-asvf4roo 32 24 SARS SARS NNP cord-315656-asvf4roo 32 25 - - HYPH cord-315656-asvf4roo 32 26 CoV-2 CoV-2 NNP cord-315656-asvf4roo 32 27 is be VBZ cord-315656-asvf4roo 32 28 the the DT cord-315656-asvf4roo 32 29 third third JJ cord-315656-asvf4roo 32 30 coronavirus coronavirus NN cord-315656-asvf4roo 32 31 that that WDT cord-315656-asvf4roo 32 32 can can MD cord-315656-asvf4roo 32 33 cause cause VB cord-315656-asvf4roo 32 34 severe severe JJ cord-315656-asvf4roo 32 35 respiratory respiratory JJ cord-315656-asvf4roo 32 36 diseases disease NNS cord-315656-asvf4roo 32 37 . . . cord-315656-asvf4roo 33 1 Genomic genomic JJ cord-315656-asvf4roo 33 2 analysis analysis NN cord-315656-asvf4roo 33 3 shows show VBZ cord-315656-asvf4roo 33 4 that that IN cord-315656-asvf4roo 33 5 SARS SARS NNP cord-315656-asvf4roo 33 6 - - HYPH cord-315656-asvf4roo 33 7 CoV-2 CoV-2 NNP cord-315656-asvf4roo 33 8 is be VBZ cord-315656-asvf4roo 33 9 in in IN cord-315656-asvf4roo 33 10 the the DT cord-315656-asvf4roo 33 11 same same JJ cord-315656-asvf4roo 33 12 β β NN cord-315656-asvf4roo 33 13 - - HYPH cord-315656-asvf4roo 33 14 coronavirus coronavirus NN cord-315656-asvf4roo 33 15 clade clade NN cord-315656-asvf4roo 33 16 as as IN cord-315656-asvf4roo 33 17 SARS SARS NNP cord-315656-asvf4roo 33 18 - - HYPH cord-315656-asvf4roo 33 19 CoV CoV NNP cord-315656-asvf4roo 33 20 and and CC cord-315656-asvf4roo 33 21 MERS MERS NNP cord-315656-asvf4roo 33 22 - - HYPH cord-315656-asvf4roo 33 23 CoV CoV NNP cord-315656-asvf4roo 33 24 , , , cord-315656-asvf4roo 33 25 and and CC cord-315656-asvf4roo 33 26 shares share VBZ cord-315656-asvf4roo 33 27 a a DT cord-315656-asvf4roo 33 28 highly highly RB cord-315656-asvf4roo 33 29 homologous homologous JJ cord-315656-asvf4roo 33 30 sequence sequence NN cord-315656-asvf4roo 33 31 with with IN cord-315656-asvf4roo 33 32 SARS SARS NNP cord-315656-asvf4roo 33 33 - - HYPH cord-315656-asvf4roo 33 34 CoV CoV NNP cord-315656-asvf4roo 33 35 ( ( -LRB- cord-315656-asvf4roo 33 36 9 9 CD cord-315656-asvf4roo 33 37 ) ) -RRB- cord-315656-asvf4roo 33 38 . . . cord-315656-asvf4roo 34 1 Scientists scientist NNS cord-315656-asvf4roo 34 2 thus thus RB cord-315656-asvf4roo 34 3 have have VBP cord-315656-asvf4roo 34 4 put put VBN cord-315656-asvf4roo 34 5 great great JJ cord-315656-asvf4roo 34 6 efforts effort NNS cord-315656-asvf4roo 34 7 in in IN cord-315656-asvf4roo 34 8 clarifying clarify VBG cord-315656-asvf4roo 34 9 how how WRB cord-315656-asvf4roo 34 10 it -PRON- PRP cord-315656-asvf4roo 34 11 resembles resemble VBZ cord-315656-asvf4roo 34 12 and and CC cord-315656-asvf4roo 34 13 differs differ VBZ cord-315656-asvf4roo 34 14 from from IN cord-315656-asvf4roo 34 15 SARS SARS NNP cord-315656-asvf4roo 34 16 - - HYPH cord-315656-asvf4roo 34 17 CoV CoV NNP cord-315656-asvf4roo 34 18 and and CC cord-315656-asvf4roo 34 19 MERS MERS NNP cord-315656-asvf4roo 34 20 - - HYPH cord-315656-asvf4roo 34 21 CoV CoV NNP cord-315656-asvf4roo 34 22 at at IN cord-315656-asvf4roo 34 23 multiple multiple JJ cord-315656-asvf4roo 34 24 levels level NNS cord-315656-asvf4roo 34 25 that that WDT cord-315656-asvf4roo 34 26 may may MD cord-315656-asvf4roo 34 27 shed shed VB cord-315656-asvf4roo 34 28 light light NN cord-315656-asvf4roo 34 29 on on IN cord-315656-asvf4roo 34 30 the the DT cord-315656-asvf4roo 34 31 COVID-19 COVID-19 NNP cord-315656-asvf4roo 34 32 therapeutics therapeutic NNS cord-315656-asvf4roo 34 33 and and CC cord-315656-asvf4roo 34 34 drug drug NN cord-315656-asvf4roo 34 35 repurposing repurposing NN cord-315656-asvf4roo 34 36 . . . cord-315656-asvf4roo 35 1 Specifically specifically RB cord-315656-asvf4roo 35 2 , , , cord-315656-asvf4roo 35 3 the the DT cord-315656-asvf4roo 35 4 similarity similarity NN cord-315656-asvf4roo 35 5 goes go VBZ cord-315656-asvf4roo 35 6 to to IN cord-315656-asvf4roo 35 7 the the DT cord-315656-asvf4roo 35 8 systemic systemic JJ cord-315656-asvf4roo 35 9 organ organ NN cord-315656-asvf4roo 35 10 injury injury NN cord-315656-asvf4roo 35 11 and and CC cord-315656-asvf4roo 35 12 cytokine cytokine NN cord-315656-asvf4roo 35 13 storm storm NN cord-315656-asvf4roo 35 14 in in IN cord-315656-asvf4roo 35 15 severe severe JJ cord-315656-asvf4roo 35 16 situations situation NNS cord-315656-asvf4roo 35 17 . . . cord-315656-asvf4roo 36 1 Although although IN cord-315656-asvf4roo 36 2 the the DT cord-315656-asvf4roo 36 3 symptoms symptom NNS cord-315656-asvf4roo 36 4 in in IN cord-315656-asvf4roo 36 5 lungs lung NNS cord-315656-asvf4roo 36 6 are be VBP cord-315656-asvf4roo 36 7 manifested manifest VBN cord-315656-asvf4roo 36 8 at at IN cord-315656-asvf4roo 36 9 an an DT cord-315656-asvf4roo 36 10 early early JJ cord-315656-asvf4roo 36 11 stage stage NN cord-315656-asvf4roo 36 12 , , , cord-315656-asvf4roo 36 13 they -PRON- PRP cord-315656-asvf4roo 36 14 can can MD cord-315656-asvf4roo 36 15 be be VB cord-315656-asvf4roo 36 16 extended extend VBN cord-315656-asvf4roo 36 17 to to IN cord-315656-asvf4roo 36 18 multiple multiple JJ cord-315656-asvf4roo 36 19 organs organ NNS cord-315656-asvf4roo 36 20 including include VBG cord-315656-asvf4roo 36 21 the the DT cord-315656-asvf4roo 36 22 blood blood NN cord-315656-asvf4roo 36 23 vessels vessel NNS cord-315656-asvf4roo 36 24 , , , cord-315656-asvf4roo 36 25 heart heart NN cord-315656-asvf4roo 36 26 , , , cord-315656-asvf4roo 36 27 gut gut NN cord-315656-asvf4roo 36 28 , , , cord-315656-asvf4roo 36 29 kidneys kidney NNS cord-315656-asvf4roo 36 30 , , , cord-315656-asvf4roo 36 31 testicles testicle NNS cord-315656-asvf4roo 36 32 , , , cord-315656-asvf4roo 36 33 and and CC cord-315656-asvf4roo 36 34 brain brain NN cord-315656-asvf4roo 36 35 , , , cord-315656-asvf4roo 36 36 which which WDT cord-315656-asvf4roo 36 37 are be VBP cord-315656-asvf4roo 36 38 well well RB cord-315656-asvf4roo 36 39 - - HYPH cord-315656-asvf4roo 36 40 known know VBN cord-315656-asvf4roo 36 41 to to TO cord-315656-asvf4roo 36 42 express express VB cord-315656-asvf4roo 36 43 ACE2 ACE2 NNP cord-315656-asvf4roo 36 44 and and CC cord-315656-asvf4roo 36 45 are be VBP cord-315656-asvf4roo 36 46 potential potential JJ cord-315656-asvf4roo 36 47 targets target NNS cord-315656-asvf4roo 36 48 of of IN cord-315656-asvf4roo 36 49 COVID-19 COVID-19 NNP cord-315656-asvf4roo 36 50 ( ( -LRB- cord-315656-asvf4roo 36 51 10 10 CD cord-315656-asvf4roo 36 52 ) ) -RRB- cord-315656-asvf4roo 36 53 . . . cord-315656-asvf4roo 37 1 Unlike unlike IN cord-315656-asvf4roo 37 2 the the DT cord-315656-asvf4roo 37 3 outbreak outbreak NN cord-315656-asvf4roo 37 4 of of IN cord-315656-asvf4roo 37 5 SARS SARS NNP cord-315656-asvf4roo 37 6 and and CC cord-315656-asvf4roo 37 7 MERS MERS NNP cord-315656-asvf4roo 37 8 , , , cord-315656-asvf4roo 37 9 the the DT cord-315656-asvf4roo 37 10 emerging emerge VBG cord-315656-asvf4roo 37 11 single single JJ cord-315656-asvf4roo 37 12 - - HYPH cord-315656-asvf4roo 37 13 cell cell NN cord-315656-asvf4roo 37 14 RNA rna NN cord-315656-asvf4roo 37 15 - - HYPH cord-315656-asvf4roo 37 16 sequencing sequence VBG cord-315656-asvf4roo 37 17 ( ( -LRB- cord-315656-asvf4roo 37 18 scRNA scrna NN cord-315656-asvf4roo 37 19 - - HYPH cord-315656-asvf4roo 37 20 seq seq NN cord-315656-asvf4roo 37 21 ) ) -RRB- cord-315656-asvf4roo 37 22 during during IN cord-315656-asvf4roo 37 23 recent recent JJ cord-315656-asvf4roo 37 24 years year NNS cord-315656-asvf4roo 37 25 is be VBZ cord-315656-asvf4roo 37 26 rapidly rapidly RB cord-315656-asvf4roo 37 27 advancing advance VBG cord-315656-asvf4roo 37 28 our -PRON- PRP$ cord-315656-asvf4roo 37 29 ability ability NN cord-315656-asvf4roo 37 30 to to TO cord-315656-asvf4roo 37 31 comprehensively comprehensively RB cord-315656-asvf4roo 37 32 map map VB cord-315656-asvf4roo 37 33 the the DT cord-315656-asvf4roo 37 34 cell cell NN cord-315656-asvf4roo 37 35 types type NNS cord-315656-asvf4roo 37 36 with with IN cord-315656-asvf4roo 37 37 ACE2 ACE2 NNP cord-315656-asvf4roo 37 38 / / SYM cord-315656-asvf4roo 37 39 TMPRSS2 TMPRSS2 NNP cord-315656-asvf4roo 37 40 expression expression NN cord-315656-asvf4roo 37 41 ( ( -LRB- cord-315656-asvf4roo 37 42 11 11 CD cord-315656-asvf4roo 37 43 ) ) -RRB- cord-315656-asvf4roo 37 44 ( ( -LRB- cord-315656-asvf4roo 37 45 12 12 CD cord-315656-asvf4roo 37 46 ) ) -RRB- cord-315656-asvf4roo 37 47 ( ( -LRB- cord-315656-asvf4roo 37 48 13 13 CD cord-315656-asvf4roo 37 49 ) ) -RRB- cord-315656-asvf4roo 38 1 ( ( -LRB- cord-315656-asvf4roo 38 2 14 14 CD cord-315656-asvf4roo 38 3 ) ) -RRB- cord-315656-asvf4roo 38 4 ( ( -LRB- cord-315656-asvf4roo 38 5 15 15 CD cord-315656-asvf4roo 38 6 ) ) -RRB- cord-315656-asvf4roo 38 7 . . . cord-315656-asvf4roo 39 1 It -PRON- PRP cord-315656-asvf4roo 39 2 is be VBZ cord-315656-asvf4roo 39 3 shown show VBN cord-315656-asvf4roo 39 4 that that IN cord-315656-asvf4roo 39 5 , , , cord-315656-asvf4roo 39 6 besides besides IN cord-315656-asvf4roo 39 7 pneumocytes pneumocyte NNS cord-315656-asvf4roo 39 8 , , , cord-315656-asvf4roo 39 9 ACE2 ACE2 NNP cord-315656-asvf4roo 39 10 receptors receptor NNS cord-315656-asvf4roo 39 11 are be VBP cord-315656-asvf4roo 39 12 present present JJ cord-315656-asvf4roo 39 13 in in IN cord-315656-asvf4roo 39 14 various various JJ cord-315656-asvf4roo 39 15 cell cell NN cord-315656-asvf4roo 39 16 types type NNS cord-315656-asvf4roo 39 17 including include VBG cord-315656-asvf4roo 39 18 the the DT cord-315656-asvf4roo 39 19 nasal nasal JJ cord-315656-asvf4roo 39 20 epithelial epithelial JJ cord-315656-asvf4roo 39 21 cells cell NNS cord-315656-asvf4roo 39 22 , , , cord-315656-asvf4roo 39 23 oral oral JJ cord-315656-asvf4roo 39 24 mucosa mucosa JJ cord-315656-asvf4roo 39 25 epithelial epithelial JJ cord-315656-asvf4roo 39 26 cells cell NNS cord-315656-asvf4roo 39 27 , , , cord-315656-asvf4roo 39 28 cholangiocytes cholangiocyte NNS cord-315656-asvf4roo 39 29 , , , cord-315656-asvf4roo 39 30 intestine intestine NN cord-315656-asvf4roo 39 31 enterocytes enterocyte NNS cord-315656-asvf4roo 39 32 and and CC cord-315656-asvf4roo 39 33 , , , cord-315656-asvf4roo 39 34 importantly importantly RB cord-315656-asvf4roo 39 35 , , , cord-315656-asvf4roo 39 36 immune immune JJ cord-315656-asvf4roo 39 37 cells cell NNS cord-315656-asvf4roo 39 38 such such JJ cord-315656-asvf4roo 39 39 as as IN cord-315656-asvf4roo 39 40 B b NN cord-315656-asvf4roo 39 41 cells cell NNS cord-315656-asvf4roo 39 42 , , , cord-315656-asvf4roo 39 43 Natural natural JJ cord-315656-asvf4roo 39 44 killer killer NN cord-315656-asvf4roo 39 45 T t NN cord-315656-asvf4roo 39 46 cells cell NNS cord-315656-asvf4roo 39 47 , , , cord-315656-asvf4roo 39 48 monocytes monocyte NNS cord-315656-asvf4roo 39 49 , , , cord-315656-asvf4roo 39 50 and and CC cord-315656-asvf4roo 39 51 macrophages macrophage NNS cord-315656-asvf4roo 39 52 ( ( -LRB- cord-315656-asvf4roo 39 53 11 11 CD cord-315656-asvf4roo 39 54 , , , cord-315656-asvf4roo 39 55 13 13 CD cord-315656-asvf4roo 39 56 , , , cord-315656-asvf4roo 39 57 ( ( -LRB- cord-315656-asvf4roo 39 58 16 16 CD cord-315656-asvf4roo 39 59 ) ) -RRB- cord-315656-asvf4roo 39 60 ( ( -LRB- cord-315656-asvf4roo 39 61 17 17 CD cord-315656-asvf4roo 39 62 ) ) -RRB- cord-315656-asvf4roo 39 63 ( ( -LRB- cord-315656-asvf4roo 39 64 18 18 CD cord-315656-asvf4roo 39 65 ) ) -RRB- cord-315656-asvf4roo 39 66 ( ( -LRB- cord-315656-asvf4roo 39 67 19 19 CD cord-315656-asvf4roo 39 68 ) ) -RRB- cord-315656-asvf4roo 39 69 . . . cord-315656-asvf4roo 40 1 Notably notably RB cord-315656-asvf4roo 40 2 , , , cord-315656-asvf4roo 40 3 ACE2 ACE2 NNP cord-315656-asvf4roo 40 4 is be VBZ cord-315656-asvf4roo 40 5 also also RB cord-315656-asvf4roo 40 6 expressing express VBG cord-315656-asvf4roo 40 7 in in IN cord-315656-asvf4roo 40 8 the the DT cord-315656-asvf4roo 40 9 brain brain NN cord-315656-asvf4roo 40 10 , , , cord-315656-asvf4roo 40 11 in in IN cord-315656-asvf4roo 40 12 which which WDT cord-315656-asvf4roo 40 13 eight eight CD cord-315656-asvf4roo 40 14 cell cell NN cord-315656-asvf4roo 40 15 types type NNS cord-315656-asvf4roo 40 16 were be VBD cord-315656-asvf4roo 40 17 identified identify VBN cord-315656-asvf4roo 40 18 including include VBG cord-315656-asvf4roo 40 19 excitatory excitatory JJ cord-315656-asvf4roo 40 20 neurons neuron NNS cord-315656-asvf4roo 40 21 , , , cord-315656-asvf4roo 40 22 inhibitory inhibitory JJ cord-315656-asvf4roo 40 23 neurons neuron NNS cord-315656-asvf4roo 40 24 , , , cord-315656-asvf4roo 40 25 oligodendrocyte oligodendrocyte VBN cord-315656-asvf4roo 40 26 progenitors progenitor NNS cord-315656-asvf4roo 40 27 , , , cord-315656-asvf4roo 40 28 oligodendrocytes oligodendrocyte NNS cord-315656-asvf4roo 40 29 , , , cord-315656-asvf4roo 40 30 microglia microglia NNS cord-315656-asvf4roo 40 31 , , , cord-315656-asvf4roo 40 32 astrocytes astrocyte NNS cord-315656-asvf4roo 40 33 , , , cord-315656-asvf4roo 40 34 pericytes pericyte NNS cord-315656-asvf4roo 40 35 , , , cord-315656-asvf4roo 40 36 and and CC cord-315656-asvf4roo 40 37 endothelial endothelial JJ cord-315656-asvf4roo 40 38 cells cell NNS cord-315656-asvf4roo 40 39 ( ( -LRB- cord-315656-asvf4roo 40 40 13 13 CD cord-315656-asvf4roo 40 41 ) ) -RRB- cord-315656-asvf4roo 40 42 . . . cord-315656-asvf4roo 41 1 However however RB cord-315656-asvf4roo 41 2 , , , cord-315656-asvf4roo 41 3 other other JJ cord-315656-asvf4roo 41 4 studies study NNS cord-315656-asvf4roo 41 5 showed show VBD cord-315656-asvf4roo 41 6 contradictory contradictory JJ cord-315656-asvf4roo 41 7 results result NNS cord-315656-asvf4roo 41 8 that that IN cord-315656-asvf4roo 41 9 glial glial JJ cord-315656-asvf4roo 41 10 cells cell NNS cord-315656-asvf4roo 41 11 may may MD cord-315656-asvf4roo 41 12 not not RB cord-315656-asvf4roo 41 13 express express VB cord-315656-asvf4roo 41 14 ACE2 ACE2 NNP cord-315656-asvf4roo 41 15 , , , cord-315656-asvf4roo 41 16 but but CC cord-315656-asvf4roo 41 17 instead instead RB cord-315656-asvf4roo 41 18 might may MD cord-315656-asvf4roo 41 19 express express VB cord-315656-asvf4roo 41 20 non non JJ cord-315656-asvf4roo 41 21 - - JJ cord-315656-asvf4roo 41 22 canonical canonical JJ cord-315656-asvf4roo 41 23 docking docking NN cord-315656-asvf4roo 41 24 receptors receptor NNS cord-315656-asvf4roo 41 25 such such JJ cord-315656-asvf4roo 41 26 as as IN cord-315656-asvf4roo 41 27 Basigin Basigin NNP cord-315656-asvf4roo 41 28 ( ( -LRB- cord-315656-asvf4roo 41 29 BSG BSG NNP cord-315656-asvf4roo 41 30 ) ) -RRB- cord-315656-asvf4roo 41 31 or or CC cord-315656-asvf4roo 41 32 Neuropilin-1 Neuropilin-1 NNP cord-315656-asvf4roo 41 33 ( ( -LRB- cord-315656-asvf4roo 41 34 NRP1 NRP1 NNP cord-315656-asvf4roo 41 35 ) ) -RRB- cord-315656-asvf4roo 41 36 to to TO cord-315656-asvf4roo 41 37 facilitate facilitate VB cord-315656-asvf4roo 41 38 viral viral JJ cord-315656-asvf4roo 41 39 cell cell NN cord-315656-asvf4roo 41 40 entry entry NN cord-315656-asvf4roo 41 41 and and CC cord-315656-asvf4roo 41 42 replication replication NN cord-315656-asvf4roo 41 43 ( ( -LRB- cord-315656-asvf4roo 41 44 20 20 CD cord-315656-asvf4roo 41 45 , , , cord-315656-asvf4roo 41 46 21 21 CD cord-315656-asvf4roo 41 47 ) ) -RRB- cord-315656-asvf4roo 41 48 . . . cord-315656-asvf4roo 42 1 Nevertheless nevertheless RB cord-315656-asvf4roo 42 2 , , , cord-315656-asvf4roo 42 3 the the DT cord-315656-asvf4roo 42 4 present present NN cord-315656-asvf4roo 42 5 of of IN cord-315656-asvf4roo 42 6 ACE2 ACE2 NNP cord-315656-asvf4roo 42 7 receptors receptor NNS cord-315656-asvf4roo 42 8 in in IN cord-315656-asvf4roo 42 9 multiple multiple JJ cord-315656-asvf4roo 42 10 organs organ NNS cord-315656-asvf4roo 42 11 underlies underlie VBZ cord-315656-asvf4roo 42 12 the the DT cord-315656-asvf4roo 42 13 systemic systemic JJ cord-315656-asvf4roo 42 14 impairment impairment NN cord-315656-asvf4roo 42 15 by by IN cord-315656-asvf4roo 42 16 SARS SARS NNP cord-315656-asvf4roo 42 17 - - HYPH cord-315656-asvf4roo 42 18 CoV-2 CoV-2 NNP cord-315656-asvf4roo 42 19 infection infection NN cord-315656-asvf4roo 42 20 . . . cord-315656-asvf4roo 43 1 Coronavirus Coronavirus NNP cord-315656-asvf4roo 43 2 infection infection NN cord-315656-asvf4roo 43 3 has have VBZ cord-315656-asvf4roo 43 4 been be VBN cord-315656-asvf4roo 43 5 associated associate VBN cord-315656-asvf4roo 43 6 with with IN cord-315656-asvf4roo 43 7 neurological neurological JJ cord-315656-asvf4roo 43 8 manifestations manifestation NNS cord-315656-asvf4roo 43 9 such such JJ cord-315656-asvf4roo 43 10 as as IN cord-315656-asvf4roo 43 11 stroke stroke NN cord-315656-asvf4roo 43 12 , , , cord-315656-asvf4roo 43 13 seizure seizure NN cord-315656-asvf4roo 43 14 , , , cord-315656-asvf4roo 43 15 convulsions convulsion NNS cord-315656-asvf4roo 43 16 , , , cord-315656-asvf4roo 43 17 mental mental JJ cord-315656-asvf4roo 43 18 confusion confusion NN cord-315656-asvf4roo 43 19 , , , cord-315656-asvf4roo 43 20 and and CC cord-315656-asvf4roo 43 21 encephalitis encephalitis JJ cord-315656-asvf4roo 43 22 ( ( -LRB- cord-315656-asvf4roo 43 23 22 22 CD cord-315656-asvf4roo 43 24 , , , cord-315656-asvf4roo 43 25 23 23 CD cord-315656-asvf4roo 43 26 ) ) -RRB- cord-315656-asvf4roo 43 27 . . . cord-315656-asvf4roo 44 1 During during IN cord-315656-asvf4roo 44 2 the the DT cord-315656-asvf4roo 44 3 outbreak outbreak NN cord-315656-asvf4roo 44 4 in in IN cord-315656-asvf4roo 44 5 2003 2003 CD cord-315656-asvf4roo 44 6 , , , cord-315656-asvf4roo 44 7 SARS SARS NNP cord-315656-asvf4roo 44 8 - - HYPH cord-315656-asvf4roo 44 9 CoV CoV NNP cord-315656-asvf4roo 44 10 could could MD cord-315656-asvf4roo 44 11 induce induce VB cord-315656-asvf4roo 44 12 neurological neurological JJ cord-315656-asvf4roo 44 13 diseases disease NNS cord-315656-asvf4roo 44 14 such such JJ cord-315656-asvf4roo 44 15 as as IN cord-315656-asvf4roo 44 16 polyneuropathy polyneuropathy NN cord-315656-asvf4roo 44 17 , , , cord-315656-asvf4roo 44 18 encephalitis encephalitis RB cord-315656-asvf4roo 44 19 , , , cord-315656-asvf4roo 44 20 and and CC cord-315656-asvf4roo 44 21 aortic aortic JJ cord-315656-asvf4roo 44 22 ischemic ischemic JJ cord-315656-asvf4roo 44 23 stroke stroke NN cord-315656-asvf4roo 44 24 ( ( -LRB- cord-315656-asvf4roo 44 25 24 24 CD cord-315656-asvf4roo 44 26 ) ) -RRB- cord-315656-asvf4roo 44 27 . . . cord-315656-asvf4roo 45 1 The the DT cord-315656-asvf4roo 45 2 virus virus NN cord-315656-asvf4roo 45 3 itself -PRON- PRP cord-315656-asvf4roo 45 4 has have VBZ cord-315656-asvf4roo 45 5 been be VBN cord-315656-asvf4roo 45 6 detected detect VBN cord-315656-asvf4roo 45 7 in in IN cord-315656-asvf4roo 45 8 the the DT cord-315656-asvf4roo 45 9 cerebrospinal cerebrospinal JJ cord-315656-asvf4roo 45 10 fluid fluid NN cord-315656-asvf4roo 45 11 ( ( -LRB- cord-315656-asvf4roo 45 12 CSF CSF NNP cord-315656-asvf4roo 45 13 ) ) -RRB- cord-315656-asvf4roo 45 14 samples sample NNS cord-315656-asvf4roo 45 15 , , , cord-315656-asvf4roo 45 16 and and CC cord-315656-asvf4roo 45 17 even even RB cord-315656-asvf4roo 45 18 the the DT cord-315656-asvf4roo 45 19 brain brain NN cord-315656-asvf4roo 45 20 of of IN cord-315656-asvf4roo 45 21 deceased deceased JJ cord-315656-asvf4roo 45 22 patients patient NNS cord-315656-asvf4roo 45 23 ( ( -LRB- cord-315656-asvf4roo 45 24 25 25 CD cord-315656-asvf4roo 45 25 , , , cord-315656-asvf4roo 45 26 26 26 CD cord-315656-asvf4roo 45 27 ) ) -RRB- cord-315656-asvf4roo 45 28 . . . cord-315656-asvf4roo 46 1 In in IN cord-315656-asvf4roo 46 2 2012 2012 CD cord-315656-asvf4roo 46 3 , , , cord-315656-asvf4roo 46 4 nearly nearly RB cord-315656-asvf4roo 46 5 20 20 CD cord-315656-asvf4roo 46 6 % % NN cord-315656-asvf4roo 46 7 of of IN cord-315656-asvf4roo 46 8 patients patient NNS cord-315656-asvf4roo 46 9 with with IN cord-315656-asvf4roo 46 10 MERS MERS NNP cord-315656-asvf4roo 46 11 - - HYPH cord-315656-asvf4roo 46 12 CoV CoV NNP cord-315656-asvf4roo 46 13 infection infection NN cord-315656-asvf4roo 46 14 developed develop VBD cord-315656-asvf4roo 46 15 neurological neurological JJ cord-315656-asvf4roo 46 16 symptoms symptom NNS cord-315656-asvf4roo 46 17 , , , cord-315656-asvf4roo 46 18 including include VBG cord-315656-asvf4roo 46 19 ischemic ischemic JJ cord-315656-asvf4roo 46 20 stroke stroke NN cord-315656-asvf4roo 46 21 , , , cord-315656-asvf4roo 46 22 paralysis paralysis NN cord-315656-asvf4roo 46 23 , , , cord-315656-asvf4roo 46 24 unconsciousness unconsciousness NN cord-315656-asvf4roo 46 25 , , , cord-315656-asvf4roo 46 26 Guillain Guillain NNP cord-315656-asvf4roo 46 27 - - HYPH cord-315656-asvf4roo 46 28 Barre Barre NNP cord-315656-asvf4roo 46 29 syndrome syndrome NN cord-315656-asvf4roo 46 30 , , , cord-315656-asvf4roo 46 31 and and CC cord-315656-asvf4roo 46 32 other other JJ cord-315656-asvf4roo 46 33 infectious infectious JJ cord-315656-asvf4roo 46 34 neuropathy neuropathy NN cord-315656-asvf4roo 46 35 ( ( -LRB- cord-315656-asvf4roo 46 36 27 27 CD cord-315656-asvf4roo 46 37 ) ) -RRB- cord-315656-asvf4roo 46 38 . . . cord-315656-asvf4roo 47 1 It -PRON- PRP cord-315656-asvf4roo 47 2 is be VBZ cord-315656-asvf4roo 47 3 thus thus RB cord-315656-asvf4roo 47 4 not not RB cord-315656-asvf4roo 47 5 surprising surprising JJ cord-315656-asvf4roo 47 6 to to TO cord-315656-asvf4roo 47 7 see see VB cord-315656-asvf4roo 47 8 neurological neurological JJ cord-315656-asvf4roo 47 9 manifestations manifestation NNS cord-315656-asvf4roo 47 10 in in IN cord-315656-asvf4roo 47 11 COVID-19 covid-19 JJ cord-315656-asvf4roo 47 12 patients patient NNS cord-315656-asvf4roo 47 13 as as RB cord-315656-asvf4roo 47 14 well well RB cord-315656-asvf4roo 47 15 ( ( -LRB- cord-315656-asvf4roo 47 16 28 28 CD cord-315656-asvf4roo 47 17 ) ) -RRB- cord-315656-asvf4roo 47 18 ( ( -LRB- cord-315656-asvf4roo 47 19 29 29 CD cord-315656-asvf4roo 47 20 ) ) -RRB- cord-315656-asvf4roo 47 21 ( ( -LRB- cord-315656-asvf4roo 47 22 30 30 CD cord-315656-asvf4roo 47 23 ) ) -RRB- cord-315656-asvf4roo 47 24 . . . cord-315656-asvf4roo 48 1 In in IN cord-315656-asvf4roo 48 2 general general JJ cord-315656-asvf4roo 48 3 , , , cord-315656-asvf4roo 48 4 COVID-19 covid-19 JJ cord-315656-asvf4roo 48 5 neurological neurological JJ cord-315656-asvf4roo 48 6 manifestations manifestation NNS cord-315656-asvf4roo 48 7 could could MD cord-315656-asvf4roo 48 8 be be VB cord-315656-asvf4roo 48 9 classified classify VBN cord-315656-asvf4roo 48 10 into into IN cord-315656-asvf4roo 48 11 two two CD cord-315656-asvf4roo 48 12 categories category NNS cord-315656-asvf4roo 48 13 : : : cord-315656-asvf4roo 48 14 central central JJ cord-315656-asvf4roo 48 15 nervous nervous JJ cord-315656-asvf4roo 48 16 system system NN cord-315656-asvf4roo 48 17 ( ( -LRB- cord-315656-asvf4roo 48 18 CNS CNS NNP cord-315656-asvf4roo 48 19 ) ) -RRB- cord-315656-asvf4roo 48 20 symptoms symptom NNS cord-315656-asvf4roo 48 21 and and CC cord-315656-asvf4roo 48 22 peripheral peripheral JJ cord-315656-asvf4roo 48 23 nervous nervous JJ cord-315656-asvf4roo 48 24 system system NN cord-315656-asvf4roo 48 25 ( ( -LRB- cord-315656-asvf4roo 48 26 PNS PNS NNP cord-315656-asvf4roo 48 27 ) ) -RRB- cord-315656-asvf4roo 48 28 symptoms symptom NNS cord-315656-asvf4roo 48 29 . . . cord-315656-asvf4roo 49 1 CNS CNS NNP cord-315656-asvf4roo 49 2 symptoms symptom NNS cord-315656-asvf4roo 49 3 included include VBD cord-315656-asvf4roo 49 4 headache headache NN cord-315656-asvf4roo 49 5 , , , cord-315656-asvf4roo 49 6 dizziness dizziness NN cord-315656-asvf4roo 49 7 , , , cord-315656-asvf4roo 49 8 acute acute JJ cord-315656-asvf4roo 49 9 cerebrovascular cerebrovascular JJ cord-315656-asvf4roo 49 10 disease disease NN cord-315656-asvf4roo 49 11 , , , cord-315656-asvf4roo 49 12 ataxia ataxia NN cord-315656-asvf4roo 49 13 , , , cord-315656-asvf4roo 49 14 disturbance disturbance NN cord-315656-asvf4roo 49 15 of of IN cord-315656-asvf4roo 49 16 consciousness consciousness NN cord-315656-asvf4roo 49 17 , , , cord-315656-asvf4roo 49 18 and and CC cord-315656-asvf4roo 49 19 epilepsy epilepsy NN cord-315656-asvf4roo 49 20 . . . cord-315656-asvf4roo 50 1 However however RB cord-315656-asvf4roo 50 2 , , , cord-315656-asvf4roo 50 3 PNS PNS NNP cord-315656-asvf4roo 50 4 symptoms symptom NNS cord-315656-asvf4roo 50 5 are be VBP cord-315656-asvf4roo 50 6 less less RBR cord-315656-asvf4roo 50 7 severe severe JJ cord-315656-asvf4roo 50 8 and and CC cord-315656-asvf4roo 50 9 manifested manifest VBN cord-315656-asvf4roo 50 10 as as IN cord-315656-asvf4roo 50 11 neuralgia neuralgia NN cord-315656-asvf4roo 50 12 , , , cord-315656-asvf4roo 50 13 hypoplasia hypoplasia NN cord-315656-asvf4roo 50 14 , , , cord-315656-asvf4roo 50 15 hyposmia hyposmia NN cord-315656-asvf4roo 50 16 , , , cord-315656-asvf4roo 50 17 and and CC cord-315656-asvf4roo 50 18 hypogeusia hypogeusia NNP cord-315656-asvf4roo 50 19 . . . cord-315656-asvf4roo 51 1 Notably notably RB cord-315656-asvf4roo 51 2 , , , cord-315656-asvf4roo 51 3 respiratory respiratory JJ cord-315656-asvf4roo 51 4 illness illness NN cord-315656-asvf4roo 51 5 in in IN cord-315656-asvf4roo 52 1 COVID-19 covid-19 JJ cord-315656-asvf4roo 52 2 patients patient NNS cord-315656-asvf4roo 52 3 may may MD cord-315656-asvf4roo 52 4 also also RB cord-315656-asvf4roo 52 5 result result VB cord-315656-asvf4roo 52 6 from from IN cord-315656-asvf4roo 52 7 the the DT cord-315656-asvf4roo 52 8 direct direct JJ cord-315656-asvf4roo 52 9 role role NN cord-315656-asvf4roo 52 10 of of IN cord-315656-asvf4roo 52 11 SARS SARS NNP cord-315656-asvf4roo 52 12 - - HYPH cord-315656-asvf4roo 52 13 CoV-2 CoV-2 NNP cord-315656-asvf4roo 52 14 in in IN cord-315656-asvf4roo 52 15 respiratory respiratory JJ cord-315656-asvf4roo 52 16 control control NN cord-315656-asvf4roo 52 17 nuclei nucleus NNS cord-315656-asvf4roo 52 18 in in IN cord-315656-asvf4roo 52 19 the the DT cord-315656-asvf4roo 52 20 brain brain NN cord-315656-asvf4roo 52 21 ( ( -LRB- cord-315656-asvf4roo 52 22 31 31 CD cord-315656-asvf4roo 52 23 ) ) -RRB- cord-315656-asvf4roo 52 24 . . . cord-315656-asvf4roo 53 1 Interestingly interestingly RB cord-315656-asvf4roo 53 2 , , , cord-315656-asvf4roo 53 3 still still RB cord-315656-asvf4roo 53 4 many many JJ cord-315656-asvf4roo 53 5 patients patient NNS cord-315656-asvf4roo 53 6 who who WP cord-315656-asvf4roo 53 7 present present VBP cord-315656-asvf4roo 53 8 with with IN cord-315656-asvf4roo 53 9 severe severe JJ cord-315656-asvf4roo 53 10 neurological neurological JJ cord-315656-asvf4roo 53 11 complications complication NNS cord-315656-asvf4roo 53 12 have have VBP cord-315656-asvf4roo 53 13 hardly hardly RB cord-315656-asvf4roo 53 14 any any DT cord-315656-asvf4roo 53 15 respiratory respiratory JJ cord-315656-asvf4roo 53 16 symptoms symptom NNS cord-315656-asvf4roo 53 17 , , , cord-315656-asvf4roo 53 18 suggesting suggest VBG cord-315656-asvf4roo 53 19 a a DT cord-315656-asvf4roo 53 20 rather rather RB cord-315656-asvf4roo 53 21 heterogenous heterogenous JJ cord-315656-asvf4roo 53 22 neurological neurological JJ cord-315656-asvf4roo 53 23 responds respond NNS cord-315656-asvf4roo 53 24 among among IN cord-315656-asvf4roo 53 25 individuals individual NNS cord-315656-asvf4roo 53 26 , , , cord-315656-asvf4roo 53 27 and and CC cord-315656-asvf4roo 53 28 that that IN cord-315656-asvf4roo 53 29 neurological neurological JJ cord-315656-asvf4roo 53 30 manifestations manifestation NNS cord-315656-asvf4roo 53 31 did do VBD cord-315656-asvf4roo 53 32 not not RB cord-315656-asvf4roo 53 33 appear appear VB cord-315656-asvf4roo 53 34 concomitantly concomitantly RB cord-315656-asvf4roo 53 35 with with IN cord-315656-asvf4roo 53 36 respiratory respiratory JJ cord-315656-asvf4roo 53 37 symptoms symptom NNS cord-315656-asvf4roo 53 38 . . . cord-315656-asvf4roo 54 1 In in IN cord-315656-asvf4roo 54 2 a a DT cord-315656-asvf4roo 54 3 retrospective retrospective JJ cord-315656-asvf4roo 54 4 series series NN cord-315656-asvf4roo 54 5 of of IN cord-315656-asvf4roo 54 6 214 214 CD cord-315656-asvf4roo 55 1 COVID-19 covid-19 JJ cord-315656-asvf4roo 55 2 patients patient NNS cord-315656-asvf4roo 55 3 at at IN cord-315656-asvf4roo 55 4 a a DT cord-315656-asvf4roo 55 5 hospital hospital NN cord-315656-asvf4roo 55 6 located locate VBN cord-315656-asvf4roo 55 7 in in IN cord-315656-asvf4roo 55 8 the the DT cord-315656-asvf4roo 55 9 epicenter epicenter NN cord-315656-asvf4roo 55 10 of of IN cord-315656-asvf4roo 55 11 Wuhan Wuhan NNP cord-315656-asvf4roo 55 12 , , , cord-315656-asvf4roo 55 13 China China NNP cord-315656-asvf4roo 55 14 , , , cord-315656-asvf4roo 55 15 neurologic neurologic JJ cord-315656-asvf4roo 55 16 symptoms symptom NNS cord-315656-asvf4roo 55 17 were be VBD cord-315656-asvf4roo 55 18 recorded record VBN cord-315656-asvf4roo 55 19 in in IN cord-315656-asvf4roo 55 20 78 78 CD cord-315656-asvf4roo 55 21 patients patient NNS cord-315656-asvf4roo 55 22 ( ( -LRB- cord-315656-asvf4roo 55 23 36.4 36.4 CD cord-315656-asvf4roo 55 24 % % NN cord-315656-asvf4roo 55 25 ) ) -RRB- cord-315656-asvf4roo 55 26 included include VBD cord-315656-asvf4roo 55 27 headache headache NN cord-315656-asvf4roo 55 28 and and CC cord-315656-asvf4roo 55 29 disturbed disturbed JJ cord-315656-asvf4roo 55 30 consciousness consciousness NN cord-315656-asvf4roo 55 31 , , , cord-315656-asvf4roo 55 32 and and CC cord-315656-asvf4roo 55 33 6 6 CD cord-315656-asvf4roo 55 34 patients patient NNS cord-315656-asvf4roo 55 35 had have VBD cord-315656-asvf4roo 55 36 strokes stroke NNS cord-315656-asvf4roo 55 37 ( ( -LRB- cord-315656-asvf4roo 55 38 32 32 CD cord-315656-asvf4roo 55 39 ) ) -RRB- cord-315656-asvf4roo 55 40 . . . cord-315656-asvf4roo 56 1 Half half NN cord-315656-asvf4roo 56 2 of of IN cord-315656-asvf4roo 56 3 the the DT cord-315656-asvf4roo 56 4 patients patient NNS cord-315656-asvf4roo 56 5 in in IN cord-315656-asvf4roo 56 6 Strasbourg Strasbourg NNP cord-315656-asvf4roo 56 7 , , , cord-315656-asvf4roo 56 8 France France NNP cord-315656-asvf4roo 56 9 by by IN cord-315656-asvf4roo 56 10 severe severe JJ cord-315656-asvf4roo 56 11 SARS SARS NNP cord-315656-asvf4roo 56 12 - - HYPH cord-315656-asvf4roo 56 13 CoV-2 CoV-2 NNP cord-315656-asvf4roo 56 14 infection infection NN cord-315656-asvf4roo 56 15 was be VBD cord-315656-asvf4roo 56 16 associated associate VBN cord-315656-asvf4roo 56 17 with with IN cord-315656-asvf4roo 56 18 encephalopathy encephalopathy NN cord-315656-asvf4roo 56 19 , , , cord-315656-asvf4roo 56 20 prominent prominent JJ cord-315656-asvf4roo 56 21 agitation agitation NN cord-315656-asvf4roo 56 22 and and CC cord-315656-asvf4roo 56 23 confusion confusion NN cord-315656-asvf4roo 56 24 , , , cord-315656-asvf4roo 56 25 and and CC cord-315656-asvf4roo 56 26 some some DT cord-315656-asvf4roo 56 27 of of IN cord-315656-asvf4roo 56 28 them -PRON- PRP cord-315656-asvf4roo 56 29 had have VBD cord-315656-asvf4roo 56 30 single single JJ cord-315656-asvf4roo 56 31 acute acute JJ cord-315656-asvf4roo 56 32 ischemic ischemic JJ cord-315656-asvf4roo 56 33 strokes stroke NNS cord-315656-asvf4roo 56 34 after after IN cord-315656-asvf4roo 56 35 brain brain NN cord-315656-asvf4roo 56 36 imaging imaging NN cord-315656-asvf4roo 56 37 ( ( -LRB- cord-315656-asvf4roo 56 38 33 33 CD cord-315656-asvf4roo 56 39 ) ) -RRB- cord-315656-asvf4roo 56 40 . . . cord-315656-asvf4roo 57 1 In in IN cord-315656-asvf4roo 57 2 Japan Japan NNP cord-315656-asvf4roo 57 3 , , , cord-315656-asvf4roo 57 4 a a DT cord-315656-asvf4roo 57 5 COVID-19 covid-19 JJ cord-315656-asvf4roo 57 6 patient patient NN cord-315656-asvf4roo 57 7 was be VBD cord-315656-asvf4roo 57 8 brought bring VBN cord-315656-asvf4roo 57 9 in in RP cord-315656-asvf4roo 57 10 by by IN cord-315656-asvf4roo 57 11 the the DT cord-315656-asvf4roo 57 12 ambulance ambulance NN cord-315656-asvf4roo 57 13 due due IN cord-315656-asvf4roo 57 14 to to IN cord-315656-asvf4roo 57 15 a a DT cord-315656-asvf4roo 57 16 convulsion convulsion NN cord-315656-asvf4roo 57 17 accompanied accompany VBN cord-315656-asvf4roo 57 18 by by IN cord-315656-asvf4roo 57 19 unconsciousness unconsciousness NN cord-315656-asvf4roo 57 20 , , , cord-315656-asvf4roo 57 21 which which WDT cord-315656-asvf4roo 57 22 was be VBD cord-315656-asvf4roo 57 23 diagnosed diagnose VBN cord-315656-asvf4roo 57 24 with with IN cord-315656-asvf4roo 57 25 aseptic aseptic JJ cord-315656-asvf4roo 57 26 meningitis meningitis NN cord-315656-asvf4roo 57 27 / / , cord-315656-asvf4roo 57 28 encephalitis encephalitis NN cord-315656-asvf4roo 57 29 ( ( -LRB- cord-315656-asvf4roo 57 30 34 34 CD cord-315656-asvf4roo 57 31 ) ) -RRB- cord-315656-asvf4roo 57 32 . . . cord-315656-asvf4roo 58 1 Notably notably RB cord-315656-asvf4roo 58 2 for for IN cord-315656-asvf4roo 58 3 this this DT cord-315656-asvf4roo 58 4 case case NN cord-315656-asvf4roo 58 5 , , , cord-315656-asvf4roo 58 6 the the DT cord-315656-asvf4roo 58 7 specific specific JJ cord-315656-asvf4roo 58 8 SARS SARS NNP cord-315656-asvf4roo 58 9 - - HYPH cord-315656-asvf4roo 58 10 CoV-2 CoV-2 NNP cord-315656-asvf4roo 58 11 RNA RNA NNP cord-315656-asvf4roo 58 12 was be VBD cord-315656-asvf4roo 58 13 detected detect VBN cord-315656-asvf4roo 58 14 from from IN cord-315656-asvf4roo 58 15 the the DT cord-315656-asvf4roo 58 16 CSF CSF NNP cord-315656-asvf4roo 58 17 sample sample NN cord-315656-asvf4roo 58 18 . . . cord-315656-asvf4roo 59 1 Similarly similarly RB cord-315656-asvf4roo 59 2 , , , cord-315656-asvf4roo 59 3 a a DT cord-315656-asvf4roo 59 4 medical medical JJ cord-315656-asvf4roo 59 5 team team NN cord-315656-asvf4roo 59 6 at at IN cord-315656-asvf4roo 59 7 a a DT cord-315656-asvf4roo 59 8 hospital hospital NN cord-315656-asvf4roo 59 9 in in IN cord-315656-asvf4roo 59 10 Beijing Beijing NNP cord-315656-asvf4roo 59 11 , , , cord-315656-asvf4roo 59 12 China China NNP cord-315656-asvf4roo 59 13 confirmed confirm VBD cord-315656-asvf4roo 59 14 the the DT cord-315656-asvf4roo 59 15 presence presence NN cord-315656-asvf4roo 59 16 of of IN cord-315656-asvf4roo 59 17 SARS SARS NNP cord-315656-asvf4roo 59 18 - - HYPH cord-315656-asvf4roo 59 19 CoV-2 CoV-2 NNP cord-315656-asvf4roo 59 20 in in IN cord-315656-asvf4roo 59 21 the the DT cord-315656-asvf4roo 59 22 CSF CSF NNP cord-315656-asvf4roo 59 23 of of IN cord-315656-asvf4roo 59 24 a a DT cord-315656-asvf4roo 59 25 56-year 56-year JJ cord-315656-asvf4roo 59 26 - - HYPH cord-315656-asvf4roo 59 27 old old JJ cord-315656-asvf4roo 59 28 patient patient NN cord-315656-asvf4roo 59 29 with with IN cord-315656-asvf4roo 59 30 COVID-19 COVID-19 NNP cord-315656-asvf4roo 59 31 by by IN cord-315656-asvf4roo 59 32 genome genome NN cord-315656-asvf4roo 59 33 sequencing sequencing NN cord-315656-asvf4roo 59 34 , , , cord-315656-asvf4roo 59 35 thereby thereby RB cord-315656-asvf4roo 59 36 clinically clinically RB cord-315656-asvf4roo 59 37 verifying verify VBG cord-315656-asvf4roo 59 38 viral viral JJ cord-315656-asvf4roo 59 39 encephalitis encephalitis RB cord-315656-asvf4roo 59 40 ( ( -LRB- cord-315656-asvf4roo 59 41 35 35 CD cord-315656-asvf4roo 59 42 ) ) -RRB- cord-315656-asvf4roo 59 43 . . . cord-315656-asvf4roo 60 1 Notably notably RB cord-315656-asvf4roo 60 2 , , , cord-315656-asvf4roo 60 3 unlike unlike IN cord-315656-asvf4roo 60 4 encephalopathy encephalopathy NN cord-315656-asvf4roo 60 5 , , , cord-315656-asvf4roo 60 6 the the DT cord-315656-asvf4roo 60 7 acute acute JJ cord-315656-asvf4roo 60 8 stroke stroke NN cord-315656-asvf4roo 60 9 is be VBZ cord-315656-asvf4roo 60 10 most most RBS cord-315656-asvf4roo 60 11 likely likely RB cord-315656-asvf4roo 60 12 caused cause VBN cord-315656-asvf4roo 60 13 by by IN cord-315656-asvf4roo 60 14 endothelial endothelial JJ cord-315656-asvf4roo 60 15 injury injury NN cord-315656-asvf4roo 60 16 due due IN cord-315656-asvf4roo 60 17 to to IN cord-315656-asvf4roo 60 18 a a DT cord-315656-asvf4roo 60 19 pro pro JJ cord-315656-asvf4roo 60 20 - - JJ cord-315656-asvf4roo 60 21 inflammatory inflammatory JJ cord-315656-asvf4roo 60 22 hypercoagulable hypercoagulable JJ cord-315656-asvf4roo 60 23 state state NN cord-315656-asvf4roo 60 24 post post NN cord-315656-asvf4roo 61 1 SARS SARS NNP cord-315656-asvf4roo 61 2 - - HYPH cord-315656-asvf4roo 61 3 CoV-2 CoV-2 NNP cord-315656-asvf4roo 61 4 infection infection NN cord-315656-asvf4roo 61 5 ( ( -LRB- cord-315656-asvf4roo 61 6 36 36 CD cord-315656-asvf4roo 61 7 , , , cord-315656-asvf4roo 61 8 37 37 CD cord-315656-asvf4roo 61 9 ) ) -RRB- cord-315656-asvf4roo 61 10 . . . cord-315656-asvf4roo 62 1 Hence hence RB cord-315656-asvf4roo 62 2 in in IN cord-315656-asvf4roo 62 3 China China NNP cord-315656-asvf4roo 62 4 , , , cord-315656-asvf4roo 62 5 the the DT cord-315656-asvf4roo 62 6 neurological neurological JJ cord-315656-asvf4roo 62 7 symptoms symptom NNS cord-315656-asvf4roo 62 8 have have VBP cord-315656-asvf4roo 62 9 been be VBN cord-315656-asvf4roo 62 10 added add VBN cord-315656-asvf4roo 62 11 into into IN cord-315656-asvf4roo 62 12 the the DT cord-315656-asvf4roo 62 13 Diagnosis Diagnosis NNP cord-315656-asvf4roo 62 14 and and CC cord-315656-asvf4roo 62 15 FIGURE FIGURE NNP cord-315656-asvf4roo 62 16 1 1 CD cord-315656-asvf4roo 62 17 | | NNP cord-315656-asvf4roo 62 18 Proposed propose VBN cord-315656-asvf4roo 62 19 neuroinvasion neuroinvasion NN cord-315656-asvf4roo 62 20 routes route NNS cord-315656-asvf4roo 62 21 and and CC cord-315656-asvf4roo 62 22 immune immune JJ cord-315656-asvf4roo 62 23 responses response NNS cord-315656-asvf4roo 62 24 in in IN cord-315656-asvf4roo 62 25 COVID-19 COVID-19 NNP cord-315656-asvf4roo 62 26 . . . cord-315656-asvf4roo 63 1 Upon upon IN cord-315656-asvf4roo 63 2 infections infection NNS cord-315656-asvf4roo 63 3 by by IN cord-315656-asvf4roo 63 4 SARS SARS NNP cord-315656-asvf4roo 63 5 - - HYPH cord-315656-asvf4roo 63 6 CoV-2 CoV-2 NNP cord-315656-asvf4roo 63 7 coronaviruses coronaviruse NNS cord-315656-asvf4roo 63 8 , , , cord-315656-asvf4roo 63 9 COVID-19 COVID-19 NNP cord-315656-asvf4roo 63 10 patients patient NNS cord-315656-asvf4roo 63 11 exhibit exhibit VBP cord-315656-asvf4roo 63 12 multiple multiple JJ cord-315656-asvf4roo 63 13 neurological neurological JJ cord-315656-asvf4roo 63 14 complications complication NNS cord-315656-asvf4roo 63 15 , , , cord-315656-asvf4roo 63 16 which which WDT cord-315656-asvf4roo 63 17 might may MD cord-315656-asvf4roo 63 18 be be VB cord-315656-asvf4roo 63 19 due due JJ cord-315656-asvf4roo 63 20 to to IN cord-315656-asvf4roo 63 21 the the DT cord-315656-asvf4roo 63 22 effects effect NNS cord-315656-asvf4roo 63 23 through through IN cord-315656-asvf4roo 63 24 the the DT cord-315656-asvf4roo 63 25 direct direct JJ cord-315656-asvf4roo 63 26 pathway pathway NN cord-315656-asvf4roo 63 27 and and CC cord-315656-asvf4roo 63 28 the the DT cord-315656-asvf4roo 63 29 indirect indirect JJ cord-315656-asvf4roo 63 30 pathway pathway NN cord-315656-asvf4roo 63 31 . . . cord-315656-asvf4roo 64 1 ( ( -LRB- cord-315656-asvf4roo 64 2 I i NN cord-315656-asvf4roo 64 3 ) ) -RRB- cord-315656-asvf4roo 65 1 The the DT cord-315656-asvf4roo 65 2 neuroinvasive neuroinvasive JJ cord-315656-asvf4roo 65 3 properties property NNS cord-315656-asvf4roo 65 4 of of IN cord-315656-asvf4roo 65 5 SARS SARS NNP cord-315656-asvf4roo 65 6 - - HYPH cord-315656-asvf4roo 65 7 CoV-2 CoV-2 NNP cord-315656-asvf4roo 65 8 underlies underlie VBZ cord-315656-asvf4roo 65 9 the the DT cord-315656-asvf4roo 65 10 retrograde retrograde JJ cord-315656-asvf4roo 65 11 axonal axonal JJ cord-315656-asvf4roo 65 12 transport transport NN cord-315656-asvf4roo 65 13 in in IN cord-315656-asvf4roo 65 14 the the DT cord-315656-asvf4roo 65 15 direct direct JJ cord-315656-asvf4roo 65 16 pathway pathway NN cord-315656-asvf4roo 65 17 . . . cord-315656-asvf4roo 66 1 Specifically specifically RB cord-315656-asvf4roo 66 2 , , , cord-315656-asvf4roo 66 3 SARS SARS NNP cord-315656-asvf4roo 66 4 - - HYPH cord-315656-asvf4roo 66 5 CoV-2 CoV-2 NNP cord-315656-asvf4roo 66 6 viruses virus NNS cord-315656-asvf4roo 66 7 may may MD cord-315656-asvf4roo 66 8 go go VB cord-315656-asvf4roo 66 9 upward upward RB cord-315656-asvf4roo 66 10 through through IN cord-315656-asvf4roo 66 11 the the DT cord-315656-asvf4roo 66 12 olfactory olfactory JJ cord-315656-asvf4roo 66 13 nerve nerve NN cord-315656-asvf4roo 66 14 across across IN cord-315656-asvf4roo 66 15 the the DT cord-315656-asvf4roo 66 16 cribiform cribiform NN cord-315656-asvf4roo 66 17 plate plate NN cord-315656-asvf4roo 66 18 and and CC cord-315656-asvf4roo 66 19 to to IN cord-315656-asvf4roo 66 20 the the DT cord-315656-asvf4roo 66 21 brain brain NN cord-315656-asvf4roo 66 22 , , , cord-315656-asvf4roo 66 23 or or CC cord-315656-asvf4roo 66 24 alternatively alternatively RB cord-315656-asvf4roo 66 25 , , , cord-315656-asvf4roo 66 26 start start VB cord-315656-asvf4roo 66 27 from from IN cord-315656-asvf4roo 66 28 the the DT cord-315656-asvf4roo 66 29 gastrointestinal gastrointestinal JJ cord-315656-asvf4roo 66 30 system system NN cord-315656-asvf4roo 66 31 to to TO cord-315656-asvf4roo 66 32 invade invade VB cord-315656-asvf4roo 66 33 the the DT cord-315656-asvf4roo 66 34 enteric enteric JJ cord-315656-asvf4roo 66 35 nervous nervous JJ cord-315656-asvf4roo 66 36 system system NN cord-315656-asvf4roo 66 37 and and CC cord-315656-asvf4roo 66 38 finally finally RB cord-315656-asvf4roo 66 39 the the DT cord-315656-asvf4roo 66 40 brain brain NN cord-315656-asvf4roo 66 41 . . . cord-315656-asvf4roo 67 1 Several several JJ cord-315656-asvf4roo 67 2 other other JJ cord-315656-asvf4roo 67 3 invasion invasion NN cord-315656-asvf4roo 67 4 routes route NNS cord-315656-asvf4roo 67 5 for for IN cord-315656-asvf4roo 67 6 SARS SARS NNP cord-315656-asvf4roo 67 7 - - HYPH cord-315656-asvf4roo 67 8 CoV-2 CoV-2 NNP cord-315656-asvf4roo 67 9 may may MD cord-315656-asvf4roo 67 10 include include VB cord-315656-asvf4roo 67 11 blood blood NN cord-315656-asvf4roo 67 12 - - HYPH cord-315656-asvf4roo 67 13 borne bear VBN cord-315656-asvf4roo 67 14 diffusion diffusion NN cord-315656-asvf4roo 67 15 through through IN cord-315656-asvf4roo 67 16 the the DT cord-315656-asvf4roo 67 17 blood blood NN cord-315656-asvf4roo 67 18 - - HYPH cord-315656-asvf4roo 67 19 brain brain NN cord-315656-asvf4roo 67 20 barrier barrier NN cord-315656-asvf4roo 67 21 , , , cord-315656-asvf4roo 67 22 blood blood NN cord-315656-asvf4roo 67 23 - - HYPH cord-315656-asvf4roo 67 24 cerebrospinal cerebrospinal VBG cord-315656-asvf4roo 67 25 fluid fluid JJ cord-315656-asvf4roo 67 26 barrier barrier NN cord-315656-asvf4roo 67 27 and and CC cord-315656-asvf4roo 67 28 meningeal meningeal JJ cord-315656-asvf4roo 67 29 cerebrospinal cerebrospinal JJ cord-315656-asvf4roo 67 30 fluid fluid JJ cord-315656-asvf4roo 67 31 barrier barrier NN cord-315656-asvf4roo 67 32 . . . cord-315656-asvf4roo 68 1 Those those DT cord-315656-asvf4roo 68 2 invaded invade VBN cord-315656-asvf4roo 68 3 viruses virus NNS cord-315656-asvf4roo 68 4 may may MD cord-315656-asvf4roo 68 5 directly directly RB cord-315656-asvf4roo 68 6 disrupt disrupt VB cord-315656-asvf4roo 68 7 the the DT cord-315656-asvf4roo 68 8 complex complex JJ cord-315656-asvf4roo 68 9 neural neural JJ cord-315656-asvf4roo 68 10 circuits circuit NNS cord-315656-asvf4roo 68 11 , , , cord-315656-asvf4roo 68 12 and and CC cord-315656-asvf4roo 68 13 raise raise VB cord-315656-asvf4roo 68 14 a a DT cord-315656-asvf4roo 68 15 chronic chronic JJ cord-315656-asvf4roo 68 16 activation activation NN cord-315656-asvf4roo 68 17 of of IN cord-315656-asvf4roo 68 18 immune immune JJ cord-315656-asvf4roo 68 19 responses response NNS cord-315656-asvf4roo 68 20 . . . cord-315656-asvf4roo 69 1 ( ( -LRB- cord-315656-asvf4roo 69 2 II II NNP cord-315656-asvf4roo 69 3 ) ) -RRB- cord-315656-asvf4roo 70 1 Multiple multiple JJ cord-315656-asvf4roo 70 2 organ organ NN cord-315656-asvf4roo 70 3 failure failure NN cord-315656-asvf4roo 70 4 in in IN cord-315656-asvf4roo 70 5 severe severe JJ cord-315656-asvf4roo 70 6 COVID-19 covid-19 NN cord-315656-asvf4roo 70 7 is be VBZ cord-315656-asvf4roo 70 8 caused cause VBN cord-315656-asvf4roo 70 9 by by IN cord-315656-asvf4roo 70 10 the the DT cord-315656-asvf4roo 70 11 systemic systemic JJ cord-315656-asvf4roo 70 12 acute acute JJ cord-315656-asvf4roo 70 13 immune immune JJ cord-315656-asvf4roo 70 14 responses response NNS cord-315656-asvf4roo 70 15 , , , cord-315656-asvf4roo 70 16 the the DT cord-315656-asvf4roo 70 17 cytokine cytokine NN cord-315656-asvf4roo 70 18 storm storm NN cord-315656-asvf4roo 70 19 , , , cord-315656-asvf4roo 70 20 and and CC cord-315656-asvf4roo 70 21 unsurprisingly unsurprisingly RB cord-315656-asvf4roo 70 22 caused cause VBD cord-315656-asvf4roo 70 23 the the DT cord-315656-asvf4roo 70 24 brain brain NN cord-315656-asvf4roo 70 25 inflammation inflammation NN cord-315656-asvf4roo 70 26 and and CC cord-315656-asvf4roo 70 27 led lead VBD cord-315656-asvf4roo 70 28 to to IN cord-315656-asvf4roo 70 29 encephalitis encephalitis NN cord-315656-asvf4roo 70 30 . . . cord-315656-asvf4roo 71 1 However however RB cord-315656-asvf4roo 71 2 , , , cord-315656-asvf4roo 71 3 the the DT cord-315656-asvf4roo 71 4 potential potential JJ cord-315656-asvf4roo 71 5 long long JJ cord-315656-asvf4roo 71 6 - - HYPH cord-315656-asvf4roo 71 7 term term NN cord-315656-asvf4roo 71 8 effects effect NNS cord-315656-asvf4roo 71 9 in in IN cord-315656-asvf4roo 71 10 synaptic synaptic JJ cord-315656-asvf4roo 71 11 changes change NNS cord-315656-asvf4roo 71 12 and and CC cord-315656-asvf4roo 71 13 neuropsychiatric neuropsychiatric JJ cord-315656-asvf4roo 71 14 impairments impairment NNS cord-315656-asvf4roo 71 15 in in IN cord-315656-asvf4roo 71 16 key key JJ cord-315656-asvf4roo 71 17 brain brain NN cord-315656-asvf4roo 71 18 regions region NNS cord-315656-asvf4roo 71 19 should should MD cord-315656-asvf4roo 71 20 not not RB cord-315656-asvf4roo 71 21 be be VB cord-315656-asvf4roo 71 22 neglected neglect VBN cord-315656-asvf4roo 71 23 . . . cord-315656-asvf4roo 72 1 This this DT cord-315656-asvf4roo 72 2 is be VBZ cord-315656-asvf4roo 72 3 probably probably RB cord-315656-asvf4roo 72 4 caused cause VBN cord-315656-asvf4roo 72 5 by by IN cord-315656-asvf4roo 72 6 the the DT cord-315656-asvf4roo 72 7 activation activation NN cord-315656-asvf4roo 72 8 of of IN cord-315656-asvf4roo 72 9 CNS CNS NNP cord-315656-asvf4roo 72 10 immune immune JJ cord-315656-asvf4roo 72 11 cells cell NNS cord-315656-asvf4roo 72 12 that that WDT cord-315656-asvf4roo 72 13 renders render VBZ cord-315656-asvf4roo 72 14 chronic chronic JJ cord-315656-asvf4roo 72 15 immune immune JJ cord-315656-asvf4roo 72 16 imbalance imbalance NN cord-315656-asvf4roo 72 17 . . . cord-315656-asvf4roo 73 1 Treatment Treatment NNP cord-315656-asvf4roo 73 2 Protocol Protocol NNP cord-315656-asvf4roo 73 3 for for IN cord-315656-asvf4roo 73 4 2019 2019 CD cord-315656-asvf4roo 73 5 Novel Novel NNP cord-315656-asvf4roo 73 6 Coronavirus Coronavirus NNP cord-315656-asvf4roo 73 7 Pneumonia Pneumonia NNP cord-315656-asvf4roo 73 8 ( ( -LRB- cord-315656-asvf4roo 73 9 The the DT cord-315656-asvf4roo 73 10 7th 7th JJ cord-315656-asvf4roo 73 11 Trial Trial NNP cord-315656-asvf4roo 73 12 Edition Edition NNP cord-315656-asvf4roo 73 13 ) ) -RRB- cord-315656-asvf4roo 73 14 , , , cord-315656-asvf4roo 73 15 released release VBN cord-315656-asvf4roo 73 16 by by IN cord-315656-asvf4roo 73 17 National National NNP cord-315656-asvf4roo 73 18 Health Health NNP cord-315656-asvf4roo 73 19 Commission Commission NNP cord-315656-asvf4roo 73 20 & & CC cord-315656-asvf4roo 73 21 State State NNP cord-315656-asvf4roo 73 22 Administration Administration NNP cord-315656-asvf4roo 73 23 on on IN cord-315656-asvf4roo 73 24 March March NNP cord-315656-asvf4roo 73 25 3 3 CD cord-315656-asvf4roo 73 26 , , , cord-315656-asvf4roo 73 27 2020 2020 CD cord-315656-asvf4roo 73 28 , , , cord-315656-asvf4roo 73 29 which which WDT cord-315656-asvf4roo 73 30 reminds remind VBZ cord-315656-asvf4roo 73 31 us -PRON- PRP cord-315656-asvf4roo 73 32 of of IN cord-315656-asvf4roo 73 33 taking take VBG cord-315656-asvf4roo 73 34 nucleic nucleic JJ cord-315656-asvf4roo 73 35 or or CC cord-315656-asvf4roo 73 36 genomic genomic JJ cord-315656-asvf4roo 73 37 tests test NNS cord-315656-asvf4roo 73 38 with with IN cord-315656-asvf4roo 73 39 CSF CSF NNP cord-315656-asvf4roo 73 40 samples sample NNS cord-315656-asvf4roo 73 41 and and CC cord-315656-asvf4roo 73 42 carefully carefully RB cord-315656-asvf4roo 73 43 handling handle VBG cord-315656-asvf4roo 73 44 with with IN cord-315656-asvf4roo 73 45 neurological neurological JJ cord-315656-asvf4roo 73 46 complications complication NNS cord-315656-asvf4roo 73 47 to to TO cord-315656-asvf4roo 73 48 reduce reduce VB cord-315656-asvf4roo 73 49 the the DT cord-315656-asvf4roo 73 50 fatality fatality NN cord-315656-asvf4roo 73 51 of of IN cord-315656-asvf4roo 73 52 critical critical JJ cord-315656-asvf4roo 73 53 care care NN cord-315656-asvf4roo 73 54 patients patient NNS cord-315656-asvf4roo 73 55 . . . cord-315656-asvf4roo 74 1 Those those DT cord-315656-asvf4roo 74 2 neurological neurological JJ cord-315656-asvf4roo 74 3 manifestations manifestation NNS cord-315656-asvf4roo 74 4 observed observe VBN cord-315656-asvf4roo 74 5 in in IN cord-315656-asvf4roo 74 6 COVID-19 covid-19 JJ cord-315656-asvf4roo 74 7 patients patient NNS cord-315656-asvf4roo 74 8 are be VBP cord-315656-asvf4roo 74 9 reminiscent reminiscent JJ cord-315656-asvf4roo 74 10 of of IN cord-315656-asvf4roo 74 11 neuroinvasive neuroinvasive JJ cord-315656-asvf4roo 74 12 potential potential NN cord-315656-asvf4roo 74 13 of of IN cord-315656-asvf4roo 74 14 SARS SARS NNP cord-315656-asvf4roo 74 15 - - HYPH cord-315656-asvf4roo 74 16 CoV-2 CoV-2 NNP cord-315656-asvf4roo 74 17 virus virus NN cord-315656-asvf4roo 74 18 , , , cord-315656-asvf4roo 74 19 like like IN cord-315656-asvf4roo 74 20 the the DT cord-315656-asvf4roo 74 21 other other JJ cord-315656-asvf4roo 74 22 zoonotic zoonotic JJ cord-315656-asvf4roo 74 23 coronaviruses coronaviruse NNS cord-315656-asvf4roo 74 24 SARS SARS NNP cord-315656-asvf4roo 74 25 - - HYPH cord-315656-asvf4roo 74 26 CoV CoV NNP cord-315656-asvf4roo 74 27 and and CC cord-315656-asvf4roo 74 28 MERS MERS NNP cord-315656-asvf4roo 74 29 - - HYPH cord-315656-asvf4roo 74 30 CoV CoV NNP cord-315656-asvf4roo 74 31 ( ( -LRB- cord-315656-asvf4roo 74 32 31 31 CD cord-315656-asvf4roo 74 33 ) ) -RRB- cord-315656-asvf4roo 74 34 . . . cord-315656-asvf4roo 75 1 An an DT cord-315656-asvf4roo 75 2 increasing increase VBG cord-315656-asvf4roo 75 3 number number NN cord-315656-asvf4roo 75 4 of of IN cord-315656-asvf4roo 75 5 patients patient NNS cord-315656-asvf4roo 75 6 with with IN cord-315656-asvf4roo 75 7 COVID-19 COVID-19 NNP cord-315656-asvf4roo 75 8 reported report VBD cord-315656-asvf4roo 75 9 a a DT cord-315656-asvf4roo 75 10 sudden sudden JJ cord-315656-asvf4roo 75 11 loss loss NN cord-315656-asvf4roo 75 12 of of IN cord-315656-asvf4roo 75 13 smell smell NN cord-315656-asvf4roo 75 14 ( ( -LRB- cord-315656-asvf4roo 75 15 anosmia anosmia NN cord-315656-asvf4roo 75 16 ) ) -RRB- cord-315656-asvf4roo 75 17 or or CC cord-315656-asvf4roo 75 18 taste taste NN cord-315656-asvf4roo 75 19 ( ( -LRB- cord-315656-asvf4roo 75 20 dysgeusia dysgeusia NN cord-315656-asvf4roo 75 21 ) ) -RRB- cord-315656-asvf4roo 75 22 ( ( -LRB- cord-315656-asvf4roo 75 23 38 38 CD cord-315656-asvf4roo 75 24 , , , cord-315656-asvf4roo 75 25 39 39 CD cord-315656-asvf4roo 75 26 ) ) -RRB- cord-315656-asvf4roo 75 27 that that WDT cord-315656-asvf4roo 75 28 may may MD cord-315656-asvf4roo 75 29 serve serve VB cord-315656-asvf4roo 75 30 as as IN cord-315656-asvf4roo 75 31 initial initial JJ cord-315656-asvf4roo 75 32 manifestations manifestation NNS cord-315656-asvf4roo 75 33 and and CC cord-315656-asvf4roo 75 34 warning warn VBG cord-315656-asvf4roo 75 35 signs sign NNS cord-315656-asvf4roo 75 36 for for IN cord-315656-asvf4roo 75 37 possible possible JJ cord-315656-asvf4roo 75 38 subsequent subsequent JJ cord-315656-asvf4roo 75 39 CNS CNS NNP cord-315656-asvf4roo 75 40 involvement involvement NN cord-315656-asvf4roo 75 41 . . . cord-315656-asvf4roo 76 1 Given give VBN cord-315656-asvf4roo 76 2 that that IN cord-315656-asvf4roo 76 3 ACE2 ACE2 NNP cord-315656-asvf4roo 76 4 is be VBZ cord-315656-asvf4roo 76 5 highly highly RB cord-315656-asvf4roo 76 6 expressed express VBN cord-315656-asvf4roo 76 7 in in IN cord-315656-asvf4roo 76 8 nasal nasal JJ cord-315656-asvf4roo 76 9 epithelial epithelial JJ cord-315656-asvf4roo 76 10 cells cell NNS cord-315656-asvf4roo 76 11 ( ( -LRB- cord-315656-asvf4roo 76 12 11 11 CD cord-315656-asvf4roo 76 13 ) ) -RRB- cord-315656-asvf4roo 76 14 , , , cord-315656-asvf4roo 76 15 people people NNS cord-315656-asvf4roo 76 16 speculate speculate VBP cord-315656-asvf4roo 76 17 that that IN cord-315656-asvf4roo 76 18 nose nose NN cord-315656-asvf4roo 76 19 might may MD cord-315656-asvf4roo 76 20 be be VB cord-315656-asvf4roo 76 21 the the DT cord-315656-asvf4roo 76 22 first first JJ cord-315656-asvf4roo 76 23 stop stop NN cord-315656-asvf4roo 76 24 during during IN cord-315656-asvf4roo 76 25 the the DT cord-315656-asvf4roo 76 26 invasion invasion NN cord-315656-asvf4roo 76 27 of of IN cord-315656-asvf4roo 76 28 viruses virus NNS cord-315656-asvf4roo 76 29 , , , cord-315656-asvf4roo 76 30 which which WDT cord-315656-asvf4roo 76 31 then then RB cord-315656-asvf4roo 76 32 go go VBP cord-315656-asvf4roo 76 33 upward upward RB cord-315656-asvf4roo 76 34 through through IN cord-315656-asvf4roo 76 35 the the DT cord-315656-asvf4roo 76 36 olfactory olfactory JJ cord-315656-asvf4roo 76 37 nerve nerve NN cord-315656-asvf4roo 76 38 across across IN cord-315656-asvf4roo 76 39 the the DT cord-315656-asvf4roo 76 40 cribiform cribiform NN cord-315656-asvf4roo 76 41 plate plate NN cord-315656-asvf4roo 76 42 , , , cord-315656-asvf4roo 76 43 and and CC cord-315656-asvf4roo 76 44 to to IN cord-315656-asvf4roo 76 45 the the DT cord-315656-asvf4roo 76 46 brain brain NN cord-315656-asvf4roo 76 47 ( ( -LRB- cord-315656-asvf4roo 76 48 29 29 CD cord-315656-asvf4roo 76 49 ) ) -RRB- cord-315656-asvf4roo 77 1 ( ( -LRB- cord-315656-asvf4roo 77 2 Figure figure NN cord-315656-asvf4roo 77 3 1 1 CD cord-315656-asvf4roo 77 4 ) ) -RRB- cord-315656-asvf4roo 77 5 . . . cord-315656-asvf4roo 78 1 One one CD cord-315656-asvf4roo 78 2 recent recent JJ cord-315656-asvf4roo 78 3 study study NN cord-315656-asvf4roo 78 4 showed show VBD cord-315656-asvf4roo 78 5 that that IN cord-315656-asvf4roo 78 6 , , , cord-315656-asvf4roo 78 7 based base VBN cord-315656-asvf4roo 78 8 on on IN cord-315656-asvf4roo 78 9 bulk bulk JJ cord-315656-asvf4roo 78 10 and and CC cord-315656-asvf4roo 78 11 single single JJ cord-315656-asvf4roo 78 12 - - HYPH cord-315656-asvf4roo 78 13 cell cell NN cord-315656-asvf4roo 78 14 RNA rna NN cord-315656-asvf4roo 78 15 sequencing sequencing NN cord-315656-asvf4roo 78 16 , , , cord-315656-asvf4roo 78 17 ACE2 ACE2 NNP cord-315656-asvf4roo 78 18 expressed express VBD cord-315656-asvf4roo 78 19 in in IN cord-315656-asvf4roo 78 20 supporting support VBG cord-315656-asvf4roo 78 21 and and CC cord-315656-asvf4roo 78 22 stem stem NN cord-315656-asvf4roo 78 23 cells cell NNS cord-315656-asvf4roo 78 24 in in IN cord-315656-asvf4roo 78 25 the the DT cord-315656-asvf4roo 78 26 human human JJ cord-315656-asvf4roo 78 27 / / SYM cord-315656-asvf4roo 78 28 mouse mouse NN cord-315656-asvf4roo 78 29 olfactory olfactory JJ cord-315656-asvf4roo 78 30 epithelium epithelium NN cord-315656-asvf4roo 78 31 , , , cord-315656-asvf4roo 78 32 as as RB cord-315656-asvf4roo 78 33 well well RB cord-315656-asvf4roo 78 34 as as IN cord-315656-asvf4roo 78 35 vascular vascular JJ cord-315656-asvf4roo 78 36 pericytes pericyte NNS cord-315656-asvf4roo 78 37 in in IN cord-315656-asvf4roo 78 38 the the DT cord-315656-asvf4roo 78 39 mouse mouse NN cord-315656-asvf4roo 78 40 olfactory olfactory JJ cord-315656-asvf4roo 78 41 bulb bulb NN cord-315656-asvf4roo 78 42 , , , cord-315656-asvf4roo 78 43 however however RB cord-315656-asvf4roo 78 44 , , , cord-315656-asvf4roo 78 45 was be VBD cord-315656-asvf4roo 78 46 not not RB cord-315656-asvf4roo 78 47 detected detect VBN cord-315656-asvf4roo 78 48 in in IN cord-315656-asvf4roo 78 49 olfactory olfactory JJ cord-315656-asvf4roo 78 50 sensory sensory NN cord-315656-asvf4roo 78 51 or or CC cord-315656-asvf4roo 78 52 bulb bulb NN cord-315656-asvf4roo 78 53 neurons neuron NNS cord-315656-asvf4roo 78 54 ( ( -LRB- cord-315656-asvf4roo 78 55 40 40 CD cord-315656-asvf4roo 78 56 ) ) -RRB- cord-315656-asvf4roo 78 57 . . . cord-315656-asvf4roo 79 1 Furthermore furthermore RB cord-315656-asvf4roo 79 2 , , , cord-315656-asvf4roo 79 3 autopsy autopsy JJ cord-315656-asvf4roo 79 4 studies study NNS cord-315656-asvf4roo 79 5 of of IN cord-315656-asvf4roo 79 6 COVID-19 COVID-19 NNP cord-315656-asvf4roo 79 7 patients patient NNS cord-315656-asvf4roo 79 8 found find VBD cord-315656-asvf4roo 79 9 that that IN cord-315656-asvf4roo 79 10 olfactory olfactory JJ cord-315656-asvf4roo 79 11 epithelium epithelium NN cord-315656-asvf4roo 79 12 showed show VBD cord-315656-asvf4roo 79 13 prominent prominent JJ cord-315656-asvf4roo 79 14 leukocytic leukocytic JJ cord-315656-asvf4roo 79 15 infiltrates infiltrate VBZ cord-315656-asvf4roo 79 16 in in IN cord-315656-asvf4roo 79 17 the the DT cord-315656-asvf4roo 79 18 lamina lamina JJ cord-315656-asvf4roo 79 19 propria propria NN cord-315656-asvf4roo 79 20 and and CC cord-315656-asvf4roo 79 21 focal focal JJ cord-315656-asvf4roo 79 22 atrophy atrophy NN cord-315656-asvf4roo 79 23 of of IN cord-315656-asvf4roo 79 24 the the DT cord-315656-asvf4roo 79 25 mucosa mucosa NN cord-315656-asvf4roo 79 26 , , , cord-315656-asvf4roo 79 27 and and CC cord-315656-asvf4roo 79 28 olfactory olfactory JJ cord-315656-asvf4roo 79 29 nerve nerve NN cord-315656-asvf4roo 79 30 fibers fiber NNS cord-315656-asvf4roo 79 31 in in IN cord-315656-asvf4roo 79 32 the the DT cord-315656-asvf4roo 79 33 lamina lamina JJ cord-315656-asvf4roo 79 34 propria propria FW cord-315656-asvf4roo 79 35 were be VBD cord-315656-asvf4roo 79 36 lack lack NN cord-315656-asvf4roo 79 37 of of IN cord-315656-asvf4roo 79 38 myelin myelin NN cord-315656-asvf4roo 79 39 , , , cord-315656-asvf4roo 79 40 suggestive suggestive JJ cord-315656-asvf4roo 79 41 of of IN cord-315656-asvf4roo 79 42 axonal axonal JJ cord-315656-asvf4roo 79 43 damage damage NN cord-315656-asvf4roo 79 44 ( ( -LRB- cord-315656-asvf4roo 79 45 41 41 CD cord-315656-asvf4roo 79 46 ) ) -RRB- cord-315656-asvf4roo 79 47 . . . cord-315656-asvf4roo 80 1 However however RB cord-315656-asvf4roo 80 2 , , , cord-315656-asvf4roo 80 3 the the DT cord-315656-asvf4roo 80 4 clear clear JJ cord-315656-asvf4roo 80 5 evidence evidence NN cord-315656-asvf4roo 80 6 is be VBZ cord-315656-asvf4roo 80 7 still still RB cord-315656-asvf4roo 80 8 lacking lack VBG cord-315656-asvf4roo 80 9 to to TO cord-315656-asvf4roo 80 10 confirm confirm VB cord-315656-asvf4roo 80 11 whether whether IN cord-315656-asvf4roo 80 12 the the DT cord-315656-asvf4roo 80 13 olfactory olfactory JJ cord-315656-asvf4roo 80 14 neuropathy neuropathy NN cord-315656-asvf4roo 80 15 is be VBZ cord-315656-asvf4roo 80 16 due due JJ cord-315656-asvf4roo 80 17 to to IN cord-315656-asvf4roo 80 18 direct direct JJ cord-315656-asvf4roo 80 19 viral viral JJ cord-315656-asvf4roo 80 20 infection infection NN cord-315656-asvf4roo 80 21 or or CC cord-315656-asvf4roo 80 22 mediated mediate VBN cord-315656-asvf4roo 80 23 by by IN cord-315656-asvf4roo 80 24 perturbing perturb VBG cord-315656-asvf4roo 80 25 supporting support VBG cord-315656-asvf4roo 80 26 non non JJ cord-315656-asvf4roo 80 27 - - JJ cord-315656-asvf4roo 80 28 neural neural JJ cord-315656-asvf4roo 80 29 cells cell NNS cord-315656-asvf4roo 80 30 . . . cord-315656-asvf4roo 81 1 The the DT cord-315656-asvf4roo 81 2 occurrence occurrence NN cord-315656-asvf4roo 81 3 of of IN cord-315656-asvf4roo 81 4 diarrhea diarrhea NN cord-315656-asvf4roo 81 5 , , , cord-315656-asvf4roo 81 6 as as IN cord-315656-asvf4roo 81 7 another another DT cord-315656-asvf4roo 81 8 COVID-19 COVID-19 NNP cord-315656-asvf4roo 81 9 symptom symptom NN cord-315656-asvf4roo 81 10 , , , cord-315656-asvf4roo 81 11 suggests suggest VBZ cord-315656-asvf4roo 81 12 that that IN cord-315656-asvf4roo 81 13 the the DT cord-315656-asvf4roo 81 14 gastrointestinal gastrointestinal JJ cord-315656-asvf4roo 81 15 system system NN cord-315656-asvf4roo 81 16 is be VBZ cord-315656-asvf4roo 81 17 a a DT cord-315656-asvf4roo 81 18 possible possible JJ cord-315656-asvf4roo 81 19 alternative alternative JJ cord-315656-asvf4roo 81 20 pathway pathway NN cord-315656-asvf4roo 81 21 to to TO cord-315656-asvf4roo 81 22 invade invade VB cord-315656-asvf4roo 81 23 the the DT cord-315656-asvf4roo 81 24 enteric enteric JJ cord-315656-asvf4roo 81 25 nervous nervous JJ cord-315656-asvf4roo 81 26 system system NN cord-315656-asvf4roo 81 27 and and CC cord-315656-asvf4roo 81 28 finally finally RB cord-315656-asvf4roo 81 29 the the DT cord-315656-asvf4roo 81 30 brain brain NN cord-315656-asvf4roo 81 31 ( ( -LRB- cord-315656-asvf4roo 81 32 42 42 CD cord-315656-asvf4roo 81 33 ) ) -RRB- cord-315656-asvf4roo 82 1 ( ( -LRB- cord-315656-asvf4roo 82 2 Figure figure NN cord-315656-asvf4roo 82 3 1 1 CD cord-315656-asvf4roo 82 4 ) ) -RRB- cord-315656-asvf4roo 82 5 . . . cord-315656-asvf4roo 83 1 Several several JJ cord-315656-asvf4roo 83 2 invasion invasion NN cord-315656-asvf4roo 83 3 routes route NNS cord-315656-asvf4roo 83 4 for for IN cord-315656-asvf4roo 83 5 coronaviruses coronaviruse NNS cord-315656-asvf4roo 83 6 have have VBP cord-315656-asvf4roo 83 7 been be VBN cord-315656-asvf4roo 83 8 postulated postulate VBN cord-315656-asvf4roo 83 9 ( ( -LRB- cord-315656-asvf4roo 83 10 28 28 CD cord-315656-asvf4roo 83 11 , , , cord-315656-asvf4roo 83 12 43 43 CD cord-315656-asvf4roo 83 13 ) ) -RRB- cord-315656-asvf4roo 83 14 , , , cord-315656-asvf4roo 83 15 including include VBG cord-315656-asvf4roo 83 16 retrograde retrograde JJ cord-315656-asvf4roo 83 17 axonal axonal JJ cord-315656-asvf4roo 83 18 transport transport NN cord-315656-asvf4roo 83 19 , , , cord-315656-asvf4roo 83 20 blood blood NN cord-315656-asvf4roo 83 21 - - HYPH cord-315656-asvf4roo 83 22 borne bear VBN cord-315656-asvf4roo 83 23 diffusion diffusion NN cord-315656-asvf4roo 83 24 through through IN cord-315656-asvf4roo 83 25 the the DT cord-315656-asvf4roo 83 26 blood blood NN cord-315656-asvf4roo 83 27 - - HYPH cord-315656-asvf4roo 83 28 brain brain NN cord-315656-asvf4roo 83 29 barrier barrier NN cord-315656-asvf4roo 83 30 ( ( -LRB- cord-315656-asvf4roo 83 31 BBB BBB NNP cord-315656-asvf4roo 83 32 ) ) -RRB- cord-315656-asvf4roo 83 33 , , , cord-315656-asvf4roo 83 34 blood blood NN cord-315656-asvf4roo 83 35 - - HYPH cord-315656-asvf4roo 83 36 cerebrospinal cerebrospinal VBG cord-315656-asvf4roo 83 37 fluid fluid JJ cord-315656-asvf4roo 83 38 barrier barrier NN cord-315656-asvf4roo 83 39 , , , cord-315656-asvf4roo 83 40 and and CC cord-315656-asvf4roo 83 41 meningeal meningeal JJ cord-315656-asvf4roo 83 42 cerebrospinal cerebrospinal JJ cord-315656-asvf4roo 83 43 fluid fluid NN cord-315656-asvf4roo 83 44 barrier barrier NN cord-315656-asvf4roo 83 45 ( ( -LRB- cord-315656-asvf4roo 83 46 44 44 CD cord-315656-asvf4roo 83 47 ) ) -RRB- cord-315656-asvf4roo 83 48 . . . cord-315656-asvf4roo 84 1 Once once RB cord-315656-asvf4roo 84 2 in in IN cord-315656-asvf4roo 84 3 the the DT cord-315656-asvf4roo 84 4 brain brain NN cord-315656-asvf4roo 84 5 , , , cord-315656-asvf4roo 84 6 those those DT cord-315656-asvf4roo 84 7 viruses virus NNS cord-315656-asvf4roo 84 8 may may MD cord-315656-asvf4roo 84 9 directly directly RB cord-315656-asvf4roo 84 10 destroy destroy VB cord-315656-asvf4roo 84 11 the the DT cord-315656-asvf4roo 84 12 complex complex JJ cord-315656-asvf4roo 84 13 organization organization NN cord-315656-asvf4roo 84 14 of of IN cord-315656-asvf4roo 84 15 neural neural JJ cord-315656-asvf4roo 84 16 circuits circuit NNS cord-315656-asvf4roo 84 17 through through IN cord-315656-asvf4roo 84 18 neuronal neuronal JJ cord-315656-asvf4roo 84 19 damage damage NN cord-315656-asvf4roo 84 20 , , , cord-315656-asvf4roo 84 21 and and CC cord-315656-asvf4roo 84 22 raise raise VB cord-315656-asvf4roo 84 23 a a DT cord-315656-asvf4roo 84 24 chronic chronic JJ cord-315656-asvf4roo 84 25 activation activation NN cord-315656-asvf4roo 84 26 of of IN cord-315656-asvf4roo 84 27 the the DT cord-315656-asvf4roo 84 28 inflammatory inflammatory JJ cord-315656-asvf4roo 84 29 responses response NNS cord-315656-asvf4roo 84 30 . . . cord-315656-asvf4roo 85 1 Apart apart RB cord-315656-asvf4roo 85 2 from from IN cord-315656-asvf4roo 85 3 the the DT cord-315656-asvf4roo 85 4 direct direct JJ cord-315656-asvf4roo 85 5 infection infection NN cord-315656-asvf4roo 85 6 of of IN cord-315656-asvf4roo 85 7 the the DT cord-315656-asvf4roo 85 8 brain brain NN cord-315656-asvf4roo 85 9 , , , cord-315656-asvf4roo 85 10 SARS SARS NNP cord-315656-asvf4roo 85 11 - - HYPH cord-315656-asvf4roo 85 12 CoV-2 CoV-2 NNP cord-315656-asvf4roo 85 13 may may MD cord-315656-asvf4roo 85 14 cause cause VB cord-315656-asvf4roo 85 15 neurological neurological JJ cord-315656-asvf4roo 85 16 disorders disorder NNS cord-315656-asvf4roo 85 17 indirectly indirectly RB cord-315656-asvf4roo 85 18 by by IN cord-315656-asvf4roo 85 19 triggering trigger VBG cord-315656-asvf4roo 85 20 an an DT cord-315656-asvf4roo 85 21 over over RB cord-315656-asvf4roo 85 22 - - HYPH cord-315656-asvf4roo 85 23 activated activate VBN cord-315656-asvf4roo 85 24 immune immune JJ cord-315656-asvf4roo 85 25 responses response NNS cord-315656-asvf4roo 85 26 , , , cord-315656-asvf4roo 85 27 characterized characterize VBN cord-315656-asvf4roo 85 28 as as IN cord-315656-asvf4roo 85 29 cytokine cytokine NN cord-315656-asvf4roo 85 30 storm storm NN cord-315656-asvf4roo 85 31 . . . cord-315656-asvf4roo 86 1 Cytokines cytokine NNS cord-315656-asvf4roo 86 2 are be VBP cord-315656-asvf4roo 86 3 chemical chemical NN cord-315656-asvf4roo 86 4 signaling signal VBG cord-315656-asvf4roo 86 5 molecules molecule NNS cord-315656-asvf4roo 86 6 that that WDT cord-315656-asvf4roo 86 7 summon summon VBP cord-315656-asvf4roo 86 8 immune immune JJ cord-315656-asvf4roo 86 9 cells cell NNS cord-315656-asvf4roo 86 10 and and CC cord-315656-asvf4roo 86 11 mediate mediate VB cord-315656-asvf4roo 86 12 a a DT cord-315656-asvf4roo 86 13 balanced balanced JJ cord-315656-asvf4roo 86 14 immune immune JJ cord-315656-asvf4roo 86 15 response response NN cord-315656-asvf4roo 86 16 , , , cord-315656-asvf4roo 86 17 however however RB cord-315656-asvf4roo 86 18 , , , cord-315656-asvf4roo 86 19 in in IN cord-315656-asvf4roo 86 20 the the DT cord-315656-asvf4roo 86 21 cytokine cytokine NN cord-315656-asvf4roo 86 22 storm storm NN cord-315656-asvf4roo 86 23 , , , cord-315656-asvf4roo 86 24 levels level NNS cord-315656-asvf4roo 86 25 of of IN cord-315656-asvf4roo 86 26 certain certain JJ cord-315656-asvf4roo 86 27 cytokines cytokine NNS cord-315656-asvf4roo 86 28 soared soar VBD cord-315656-asvf4roo 86 29 far far RB cord-315656-asvf4roo 86 30 beyond beyond IN cord-315656-asvf4roo 86 31 the the DT cord-315656-asvf4roo 86 32 required require VBN cord-315656-asvf4roo 86 33 levels level NNS cord-315656-asvf4roo 86 34 so so IN cord-315656-asvf4roo 86 35 that that IN cord-315656-asvf4roo 86 36 the the DT cord-315656-asvf4roo 86 37 recruited recruit VBN cord-315656-asvf4roo 86 38 immune immune JJ cord-315656-asvf4roo 86 39 cells cell NNS cord-315656-asvf4roo 86 40 began begin VBD cord-315656-asvf4roo 86 41 to to TO cord-315656-asvf4roo 86 42 attack attack VB cord-315656-asvf4roo 86 43 healthy healthy JJ cord-315656-asvf4roo 86 44 tissues tissue NNS cord-315656-asvf4roo 86 45 and and CC cord-315656-asvf4roo 86 46 caused cause VBD cord-315656-asvf4roo 86 47 catastrophic catastrophic JJ cord-315656-asvf4roo 86 48 organ organ NN cord-315656-asvf4roo 86 49 failures failure NNS cord-315656-asvf4roo 86 50 . . . cord-315656-asvf4roo 87 1 Vital vital JJ cord-315656-asvf4roo 87 2 research research NN cord-315656-asvf4roo 87 3 suggests suggest VBZ cord-315656-asvf4roo 87 4 that that IN cord-315656-asvf4roo 87 5 for for IN cord-315656-asvf4roo 87 6 many many JJ cord-315656-asvf4roo 87 7 patients patient NNS cord-315656-asvf4roo 87 8 who who WP cord-315656-asvf4roo 87 9 died die VBD cord-315656-asvf4roo 87 10 from from IN cord-315656-asvf4roo 87 11 COVID-19 COVID-19 NNP cord-315656-asvf4roo 87 12 , , , cord-315656-asvf4roo 87 13 the the DT cord-315656-asvf4roo 87 14 fatal fatal JJ cord-315656-asvf4roo 87 15 blow blow NN cord-315656-asvf4roo 87 16 may may MD cord-315656-asvf4roo 87 17 be be VB cord-315656-asvf4roo 87 18 their -PRON- PRP$ cord-315656-asvf4roo 87 19 own own JJ cord-315656-asvf4roo 87 20 immune immune JJ cord-315656-asvf4roo 87 21 system system NN cord-315656-asvf4roo 87 22 rather rather RB cord-315656-asvf4roo 87 23 than than IN cord-315656-asvf4roo 87 24 the the DT cord-315656-asvf4roo 87 25 virus virus NN cord-315656-asvf4roo 87 26 itself -PRON- PRP cord-315656-asvf4roo 87 27 . . . cord-315656-asvf4roo 88 1 The the DT cord-315656-asvf4roo 88 2 initiation initiation NN cord-315656-asvf4roo 88 3 of of IN cord-315656-asvf4roo 88 4 cytokine cytokine NN cord-315656-asvf4roo 88 5 storm storm NN cord-315656-asvf4roo 88 6 is be VBZ cord-315656-asvf4roo 88 7 a a DT cord-315656-asvf4roo 88 8 common common JJ cord-315656-asvf4roo 88 9 complication complication NN cord-315656-asvf4roo 88 10 caused cause VBN cord-315656-asvf4roo 88 11 by by IN cord-315656-asvf4roo 88 12 fatal fatal JJ cord-315656-asvf4roo 88 13 respiratory respiratory JJ cord-315656-asvf4roo 88 14 coronaviruses coronaviruse NNS cord-315656-asvf4roo 88 15 , , , cord-315656-asvf4roo 88 16 like like IN cord-315656-asvf4roo 88 17 SARS SARS NNP cord-315656-asvf4roo 88 18 - - HYPH cord-315656-asvf4roo 88 19 CoV CoV NNP cord-315656-asvf4roo 88 20 and and CC cord-315656-asvf4roo 88 21 MERS MERS NNP cord-315656-asvf4roo 88 22 - - HYPH cord-315656-asvf4roo 88 23 CoV CoV NNP cord-315656-asvf4roo 88 24 , , , cord-315656-asvf4roo 88 25 and and CC cord-315656-asvf4roo 88 26 is be VBZ cord-315656-asvf4roo 88 27 the the DT cord-315656-asvf4roo 88 28 major major JJ cord-315656-asvf4roo 88 29 cause cause NN cord-315656-asvf4roo 88 30 of of IN cord-315656-asvf4roo 88 31 morbidity morbidity NN cord-315656-asvf4roo 88 32 ( ( -LRB- cord-315656-asvf4roo 88 33 45 45 CD cord-315656-asvf4roo 88 34 ) ) -RRB- cord-315656-asvf4roo 88 35 . . . cord-315656-asvf4roo 89 1 Studies study NNS cord-315656-asvf4roo 89 2 have have VBP cord-315656-asvf4roo 89 3 shown show VBN cord-315656-asvf4roo 89 4 that that IN cord-315656-asvf4roo 89 5 increased increase VBN cord-315656-asvf4roo 89 6 numbers number NNS cord-315656-asvf4roo 89 7 of of IN cord-315656-asvf4roo 89 8 pro pro JJ cord-315656-asvf4roo 89 9 - - JJ cord-315656-asvf4roo 89 10 inflammatory inflammatory JJ cord-315656-asvf4roo 89 11 cytokines cytokine NNS cord-315656-asvf4roo 89 12 ( ( -LRB- cord-315656-asvf4roo 89 13 such such JJ cord-315656-asvf4roo 89 14 as as IN cord-315656-asvf4roo 89 15 IL-1β IL-1β NNP cord-315656-asvf4roo 89 16 , , , cord-315656-asvf4roo 89 17 IL-6 IL-6 NNP cord-315656-asvf4roo 89 18 , , , cord-315656-asvf4roo 89 19 IL-12 IL-12 NNP cord-315656-asvf4roo 89 20 , , , cord-315656-asvf4roo 89 21 IFN IFN NNP cord-315656-asvf4roo 89 22 - - HYPH cord-315656-asvf4roo 89 23 γ γ NNP cord-315656-asvf4roo 89 24 , , , cord-315656-asvf4roo 89 25 IP10 IP10 NNP cord-315656-asvf4roo 89 26 , , , cord-315656-asvf4roo 89 27 and and CC cord-315656-asvf4roo 89 28 MCP1 MCP1 NNP cord-315656-asvf4roo 89 29 ) ) -RRB- cord-315656-asvf4roo 89 30 in in IN cord-315656-asvf4roo 89 31 the the DT cord-315656-asvf4roo 89 32 serum serum NN cord-315656-asvf4roo 89 33 of of IN cord-315656-asvf4roo 89 34 severe severe JJ cord-315656-asvf4roo 89 35 SARS SARS NNP cord-315656-asvf4roo 89 36 patients patient NNS cord-315656-asvf4roo 89 37 are be VBP cord-315656-asvf4roo 89 38 associated associate VBN cord-315656-asvf4roo 89 39 with with IN cord-315656-asvf4roo 89 40 lung lung NN cord-315656-asvf4roo 89 41 inflammation inflammation NN cord-315656-asvf4roo 89 42 and and CC cord-315656-asvf4roo 89 43 extensive extensive JJ cord-315656-asvf4roo 89 44 lung lung NN cord-315656-asvf4roo 89 45 injury injury NN cord-315656-asvf4roo 89 46 ( ( -LRB- cord-315656-asvf4roo 89 47 46 46 CD cord-315656-asvf4roo 89 48 ) ) -RRB- cord-315656-asvf4roo 89 49 . . . cord-315656-asvf4roo 90 1 Similarly similarly RB cord-315656-asvf4roo 90 2 in in IN cord-315656-asvf4roo 90 3 2012 2012 CD cord-315656-asvf4roo 90 4 , , , cord-315656-asvf4roo 90 5 it -PRON- PRP cord-315656-asvf4roo 90 6 was be VBD cord-315656-asvf4roo 90 7 reported report VBN cord-315656-asvf4roo 90 8 that that IN cord-315656-asvf4roo 90 9 MERS MERS NNP cord-315656-asvf4roo 90 10 - - HYPH cord-315656-asvf4roo 90 11 CoV cov NN cord-315656-asvf4roo 90 12 infection infection NN cord-315656-asvf4roo 90 13 can can MD cord-315656-asvf4roo 90 14 induce induce VB cord-315656-asvf4roo 90 15 substantially substantially RB cord-315656-asvf4roo 90 16 elevated elevate VBN cord-315656-asvf4roo 90 17 concentrations concentration NNS cord-315656-asvf4roo 90 18 of of IN cord-315656-asvf4roo 90 19 pro pro JJ cord-315656-asvf4roo 90 20 - - JJ cord-315656-asvf4roo 90 21 inflammatory inflammatory JJ cord-315656-asvf4roo 90 22 cytokines cytokine NNS cord-315656-asvf4roo 90 23 such such JJ cord-315656-asvf4roo 90 24 as as IN cord-315656-asvf4roo 90 25 IL-6 IL-6 NNP cord-315656-asvf4roo 90 26 , , , cord-315656-asvf4roo 90 27 IFN IFN NNP cord-315656-asvf4roo 90 28 - - HYPH cord-315656-asvf4roo 90 29 γ γ NNP cord-315656-asvf4roo 90 30 , , , cord-315656-asvf4roo 90 31 TNF TNF NNP cord-315656-asvf4roo 90 32 - - HYPH cord-315656-asvf4roo 90 33 α α NNP cord-315656-asvf4roo 90 34 , , , cord-315656-asvf4roo 90 35 IL-15 IL-15 NNP cord-315656-asvf4roo 90 36 , , , cord-315656-asvf4roo 90 37 and and CC cord-315656-asvf4roo 90 38 IL-17 IL-17 NNP cord-315656-asvf4roo 90 39 ( ( -LRB- cord-315656-asvf4roo 90 40 47 47 CD cord-315656-asvf4roo 90 41 , , , cord-315656-asvf4roo 90 42 48 48 CD cord-315656-asvf4roo 90 43 ) ) -RRB- cord-315656-asvf4roo 90 44 . . . cord-315656-asvf4roo 91 1 Ongoing ongoing JJ cord-315656-asvf4roo 91 2 studies study NNS cord-315656-asvf4roo 91 3 have have VBP cord-315656-asvf4roo 91 4 also also RB cord-315656-asvf4roo 91 5 been be VBN cord-315656-asvf4roo 91 6 revealing reveal VBG cord-315656-asvf4roo 91 7 the the DT cord-315656-asvf4roo 91 8 features feature NNS cord-315656-asvf4roo 91 9 of of IN cord-315656-asvf4roo 91 10 cytokine cytokine NN cord-315656-asvf4roo 91 11 storms storm NNS cord-315656-asvf4roo 91 12 in in IN cord-315656-asvf4roo 91 13 COVID-19 COVID-19 NNP cord-315656-asvf4roo 91 14 patients patient NNS cord-315656-asvf4roo 91 15 . . . cord-315656-asvf4roo 92 1 For for IN cord-315656-asvf4roo 92 2 most most JJS cord-315656-asvf4roo 92 3 severe severe JJ cord-315656-asvf4roo 92 4 patients patient NNS cord-315656-asvf4roo 92 5 with with IN cord-315656-asvf4roo 92 6 COVID-19 COVID-19 NNP cord-315656-asvf4roo 92 7 , , , cord-315656-asvf4roo 92 8 the the DT cord-315656-asvf4roo 92 9 levels level NNS cord-315656-asvf4roo 92 10 of of IN cord-315656-asvf4roo 92 11 pro pro JJ cord-315656-asvf4roo 92 12 - - JJ cord-315656-asvf4roo 92 13 inflammatory inflammatory JJ cord-315656-asvf4roo 92 14 cytokines cytokine NNS cord-315656-asvf4roo 92 15 soared soar VBD cord-315656-asvf4roo 92 16 in in IN cord-315656-asvf4roo 92 17 the the DT cord-315656-asvf4roo 92 18 serum serum NN cord-315656-asvf4roo 92 19 , , , cord-315656-asvf4roo 92 20 similar similar JJ cord-315656-asvf4roo 92 21 to to IN cord-315656-asvf4roo 92 22 that that DT cord-315656-asvf4roo 92 23 in in IN cord-315656-asvf4roo 92 24 SARS SARS NNP cord-315656-asvf4roo 92 25 and and CC cord-315656-asvf4roo 92 26 MERS MERS NNP cord-315656-asvf4roo 92 27 , , , cord-315656-asvf4roo 92 28 including include VBG cord-315656-asvf4roo 92 29 IL-6 IL-6 NNP cord-315656-asvf4roo 92 30 , , , cord-315656-asvf4roo 92 31 IL-1β IL-1β NNP cord-315656-asvf4roo 92 32 , , , cord-315656-asvf4roo 92 33 IL-2 IL-2 NNP cord-315656-asvf4roo 92 34 , , , cord-315656-asvf4roo 92 35 IL-8 IL-8 NNP cord-315656-asvf4roo 92 36 , , , cord-315656-asvf4roo 92 37 IL-17 IL-17 NNP cord-315656-asvf4roo 92 38 , , , cord-315656-asvf4roo 92 39 G G NNP cord-315656-asvf4roo 92 40 - - HYPH cord-315656-asvf4roo 92 41 CSF CSF NNP cord-315656-asvf4roo 92 42 , , , cord-315656-asvf4roo 92 43 GM GM NNP cord-315656-asvf4roo 92 44 - - HYPH cord-315656-asvf4roo 92 45 CSF CSF NNP cord-315656-asvf4roo 92 46 , , , cord-315656-asvf4roo 92 47 IP10 IP10 NNP cord-315656-asvf4roo 92 48 , , , cord-315656-asvf4roo 92 49 MCP1 MCP1 NNP cord-315656-asvf4roo 92 50 , , , cord-315656-asvf4roo 92 51 MIP1α MIP1α NNP cord-315656-asvf4roo 92 52 , , , cord-315656-asvf4roo 92 53 and and CC cord-315656-asvf4roo 92 54 TNF TNF NNP cord-315656-asvf4roo 92 55 - - HYPH cord-315656-asvf4roo 92 56 α α NNP cord-315656-asvf4roo 92 57 ( ( -LRB- cord-315656-asvf4roo 92 58 8 8 CD cord-315656-asvf4roo 92 59 , , , cord-315656-asvf4roo 92 60 ( ( -LRB- cord-315656-asvf4roo 92 61 49 49 CD cord-315656-asvf4roo 92 62 ) ) -RRB- cord-315656-asvf4roo 92 63 ( ( -LRB- cord-315656-asvf4roo 92 64 50 50 CD cord-315656-asvf4roo 92 65 ) ) -RRB- cord-315656-asvf4roo 92 66 ( ( -LRB- cord-315656-asvf4roo 92 67 51 51 CD cord-315656-asvf4roo 92 68 ) ) -RRB- cord-315656-asvf4roo 92 69 ( ( -LRB- cord-315656-asvf4roo 92 70 52 52 CD cord-315656-asvf4roo 92 71 ) ) -RRB- cord-315656-asvf4roo 92 72 ( ( -LRB- cord-315656-asvf4roo 92 73 53 53 CD cord-315656-asvf4roo 92 74 ) ) -RRB- cord-315656-asvf4roo 92 75 . . . cord-315656-asvf4roo 93 1 In in IN cord-315656-asvf4roo 93 2 addition addition NN cord-315656-asvf4roo 93 3 , , , cord-315656-asvf4roo 93 4 patients patient NNS cord-315656-asvf4roo 93 5 admitted admit VBN cord-315656-asvf4roo 93 6 to to IN cord-315656-asvf4roo 93 7 the the DT cord-315656-asvf4roo 93 8 intensive intensive JJ cord-315656-asvf4roo 93 9 care care NN cord-315656-asvf4roo 93 10 unit unit NN cord-315656-asvf4roo 93 11 ( ( -LRB- cord-315656-asvf4roo 93 12 ICU ICU NNP cord-315656-asvf4roo 93 13 ) ) -RRB- cord-315656-asvf4roo 93 14 had have VBD cord-315656-asvf4roo 93 15 higher high JJR cord-315656-asvf4roo 93 16 G G NNP cord-315656-asvf4roo 93 17 - - HYPH cord-315656-asvf4roo 93 18 CSF CSF NNP cord-315656-asvf4roo 93 19 , , , cord-315656-asvf4roo 93 20 IP10 IP10 NNP cord-315656-asvf4roo 93 21 , , , cord-315656-asvf4roo 93 22 MCP1 MCP1 NNP cord-315656-asvf4roo 93 23 , , , cord-315656-asvf4roo 93 24 MIP1A mip1a CD cord-315656-asvf4roo 93 25 , , , cord-315656-asvf4roo 93 26 and and CC cord-315656-asvf4roo 93 27 TNF TNF NNP cord-315656-asvf4roo 93 28 - - HYPH cord-315656-asvf4roo 93 29 α α NNP cord-315656-asvf4roo 93 30 concentrations concentration NNS cord-315656-asvf4roo 93 31 than than IN cord-315656-asvf4roo 93 32 patients patient NNS cord-315656-asvf4roo 93 33 not not RB cord-315656-asvf4roo 93 34 admitted admit VBN cord-315656-asvf4roo 93 35 to to IN cord-315656-asvf4roo 93 36 the the DT cord-315656-asvf4roo 93 37 ICU ICU NNP cord-315656-asvf4roo 93 38 , , , cord-315656-asvf4roo 93 39 suggesting suggest VBG cord-315656-asvf4roo 93 40 that that IN cord-315656-asvf4roo 93 41 cytokine cytokine NN cord-315656-asvf4roo 93 42 storm storm NN cord-315656-asvf4roo 93 43 is be VBZ cord-315656-asvf4roo 93 44 associated associate VBN cord-315656-asvf4roo 93 45 with with IN cord-315656-asvf4roo 93 46 disease disease NN cord-315656-asvf4roo 93 47 severity severity NN cord-315656-asvf4roo 93 48 ( ( -LRB- cord-315656-asvf4roo 93 49 8) 8) NN cord-315656-asvf4roo 93 50 . . . cord-315656-asvf4roo 94 1 High high JJ cord-315656-asvf4roo 94 2 levels level NNS cord-315656-asvf4roo 94 3 of of IN cord-315656-asvf4roo 94 4 pro pro JJ cord-315656-asvf4roo 94 5 - - JJ cord-315656-asvf4roo 94 6 inflammatory inflammatory JJ cord-315656-asvf4roo 94 7 cytokines cytokine NNS cord-315656-asvf4roo 94 8 could could MD cord-315656-asvf4roo 94 9 cause cause VB cord-315656-asvf4roo 94 10 shock shock NN cord-315656-asvf4roo 94 11 and and CC cord-315656-asvf4roo 94 12 tissue tissue NN cord-315656-asvf4roo 94 13 damage damage NN cord-315656-asvf4roo 94 14 , , , cord-315656-asvf4roo 94 15 leading lead VBG cord-315656-asvf4roo 94 16 to to IN cord-315656-asvf4roo 94 17 respiratory respiratory JJ cord-315656-asvf4roo 94 18 failure failure NN cord-315656-asvf4roo 94 19 , , , cord-315656-asvf4roo 94 20 or or CC cord-315656-asvf4roo 94 21 multiple multiple JJ cord-315656-asvf4roo 94 22 organ organ NN cord-315656-asvf4roo 94 23 failure failure NN cord-315656-asvf4roo 94 24 . . . cord-315656-asvf4roo 95 1 They -PRON- PRP cord-315656-asvf4roo 95 2 mediate mediate VBP cord-315656-asvf4roo 95 3 extensive extensive JJ cord-315656-asvf4roo 95 4 lung lung NN cord-315656-asvf4roo 95 5 pathology pathology NN cord-315656-asvf4roo 95 6 , , , cord-315656-asvf4roo 95 7 resulting result VBG cord-315656-asvf4roo 95 8 in in IN cord-315656-asvf4roo 95 9 massive massive JJ cord-315656-asvf4roo 95 10 infiltration infiltration NN cord-315656-asvf4roo 95 11 of of IN cord-315656-asvf4roo 95 12 neutrophils neutrophil NNS cord-315656-asvf4roo 95 13 and and CC cord-315656-asvf4roo 95 14 macrophages macrophage NNS cord-315656-asvf4roo 95 15 , , , cord-315656-asvf4roo 95 16 diffuse diffuse VB cord-315656-asvf4roo 95 17 alveolar alveolar JJ cord-315656-asvf4roo 95 18 injury injury NN cord-315656-asvf4roo 95 19 and and CC cord-315656-asvf4roo 95 20 the the DT cord-315656-asvf4roo 95 21 formation formation NN cord-315656-asvf4roo 95 22 of of IN cord-315656-asvf4roo 95 23 clear clear JJ cord-315656-asvf4roo 95 24 membranes membrane NNS cord-315656-asvf4roo 95 25 and and CC cord-315656-asvf4roo 95 26 diffuse diffuse VB cord-315656-asvf4roo 95 27 thickening thickening NN cord-315656-asvf4roo 95 28 of of IN cord-315656-asvf4roo 95 29 the the DT cord-315656-asvf4roo 95 30 alveolar alveolar JJ cord-315656-asvf4roo 95 31 wall wall NN cord-315656-asvf4roo 95 32 ( ( -LRB- cord-315656-asvf4roo 95 33 54 54 CD cord-315656-asvf4roo 95 34 ) ) -RRB- cord-315656-asvf4roo 95 35 . . . cord-315656-asvf4roo 96 1 Thus thus RB cord-315656-asvf4roo 96 2 , , , cord-315656-asvf4roo 96 3 it -PRON- PRP cord-315656-asvf4roo 96 4 is be VBZ cord-315656-asvf4roo 96 5 urgently urgently RB cord-315656-asvf4roo 96 6 needed need VBN cord-315656-asvf4roo 96 7 therapeutics therapeutic NNS cord-315656-asvf4roo 96 8 based base VBN cord-315656-asvf4roo 96 9 on on IN cord-315656-asvf4roo 96 10 suppressing suppress VBG cord-315656-asvf4roo 96 11 cytokine cytokine NN cord-315656-asvf4roo 96 12 storms storm NNS cord-315656-asvf4roo 96 13 . . . cord-315656-asvf4roo 97 1 In in IN cord-315656-asvf4roo 97 2 the the DT cord-315656-asvf4roo 97 3 clinical clinical JJ cord-315656-asvf4roo 97 4 practice practice NN cord-315656-asvf4roo 97 5 , , , cord-315656-asvf4roo 97 6 anti anti JJ cord-315656-asvf4roo 97 7 - - JJ cord-315656-asvf4roo 97 8 inflammatory inflammatory JJ cord-315656-asvf4roo 97 9 agents agent NNS cord-315656-asvf4roo 97 10 have have VBP cord-315656-asvf4roo 97 11 been be VBN cord-315656-asvf4roo 97 12 frequently frequently RB cord-315656-asvf4roo 97 13 used use VBN cord-315656-asvf4roo 97 14 for for IN cord-315656-asvf4roo 97 15 the the DT cord-315656-asvf4roo 97 16 treatment treatment NN cord-315656-asvf4roo 97 17 of of IN cord-315656-asvf4roo 97 18 patients patient NNS cord-315656-asvf4roo 97 19 with with IN cord-315656-asvf4roo 97 20 severe severe JJ cord-315656-asvf4roo 97 21 illness illness NN cord-315656-asvf4roo 97 22 by by IN cord-315656-asvf4roo 97 23 virus virus NN cord-315656-asvf4roo 97 24 infections infection NNS cord-315656-asvf4roo 97 25 . . . cord-315656-asvf4roo 98 1 For for IN cord-315656-asvf4roo 98 2 instance instance NN cord-315656-asvf4roo 98 3 , , , cord-315656-asvf4roo 98 4 corticosteroids corticosteroid NNS cord-315656-asvf4roo 98 5 were be VBD cord-315656-asvf4roo 98 6 ever ever RB cord-315656-asvf4roo 98 7 used use VBN cord-315656-asvf4roo 98 8 in in IN cord-315656-asvf4roo 98 9 treating treat VBG cord-315656-asvf4roo 98 10 patients patient NNS cord-315656-asvf4roo 98 11 with with IN cord-315656-asvf4roo 98 12 SARS SARS NNP cord-315656-asvf4roo 98 13 , , , cord-315656-asvf4roo 98 14 which which WDT cord-315656-asvf4roo 98 15 have have VBP cord-315656-asvf4roo 98 16 actually actually RB cord-315656-asvf4roo 98 17 saved save VBN cord-315656-asvf4roo 98 18 many many JJ cord-315656-asvf4roo 98 19 lives life NNS cord-315656-asvf4roo 98 20 and and CC cord-315656-asvf4roo 98 21 families family NNS cord-315656-asvf4roo 98 22 . . . cord-315656-asvf4roo 99 1 However however RB cord-315656-asvf4roo 99 2 , , , cord-315656-asvf4roo 99 3 long long JJ cord-315656-asvf4roo 99 4 - - HYPH cord-315656-asvf4roo 99 5 term term NN cord-315656-asvf4roo 99 6 use use NN cord-315656-asvf4roo 99 7 of of IN cord-315656-asvf4roo 99 8 this this DT cord-315656-asvf4roo 99 9 powerful powerful JJ cord-315656-asvf4roo 99 10 broad broad JJ cord-315656-asvf4roo 99 11 immunosuppressant immunosuppressant NN cord-315656-asvf4roo 99 12 can can MD cord-315656-asvf4roo 99 13 cause cause VB cord-315656-asvf4roo 99 14 various various JJ cord-315656-asvf4roo 99 15 complications complication NNS cord-315656-asvf4roo 99 16 such such JJ cord-315656-asvf4roo 99 17 as as IN cord-315656-asvf4roo 99 18 increased increase VBN cord-315656-asvf4roo 99 19 cholesterol cholesterol NN cord-315656-asvf4roo 99 20 , , , cord-315656-asvf4roo 99 21 brittle brittle JJ cord-315656-asvf4roo 99 22 bones bone NNS cord-315656-asvf4roo 99 23 , , , cord-315656-asvf4roo 99 24 cataracts cataract NNS cord-315656-asvf4roo 99 25 , , , cord-315656-asvf4roo 99 26 as as RB cord-315656-asvf4roo 99 27 well well RB cord-315656-asvf4roo 99 28 as as IN cord-315656-asvf4roo 99 29 depression depression NN cord-315656-asvf4roo 99 30 that that WDT cord-315656-asvf4roo 99 31 may may MD cord-315656-asvf4roo 99 32 greatly greatly RB cord-315656-asvf4roo 99 33 reduce reduce VB cord-315656-asvf4roo 99 34 the the DT cord-315656-asvf4roo 99 35 quality quality NN cord-315656-asvf4roo 99 36 of of IN cord-315656-asvf4roo 99 37 life life NN cord-315656-asvf4roo 99 38 . . . cord-315656-asvf4roo 100 1 More more RBR cord-315656-asvf4roo 100 2 unfortunately unfortunately RB cord-315656-asvf4roo 100 3 , , , cord-315656-asvf4roo 100 4 the the DT cord-315656-asvf4roo 100 5 latest late JJS cord-315656-asvf4roo 100 6 evidence evidence NN cord-315656-asvf4roo 100 7 from from IN cord-315656-asvf4roo 100 8 SARS SARS NNP cord-315656-asvf4roo 100 9 and and CC cord-315656-asvf4roo 100 10 MERS MERS NNP cord-315656-asvf4roo 100 11 patients patient NNS cord-315656-asvf4roo 100 12 shows show VBZ cord-315656-asvf4roo 100 13 that that IN cord-315656-asvf4roo 100 14 receiving receive VBG cord-315656-asvf4roo 100 15 corticosteroids corticosteroid NNS cord-315656-asvf4roo 100 16 has have VBZ cord-315656-asvf4roo 100 17 no no DT cord-315656-asvf4roo 100 18 effect effect NN cord-315656-asvf4roo 100 19 on on IN cord-315656-asvf4roo 100 20 mortality mortality NN cord-315656-asvf4roo 100 21 , , , cord-315656-asvf4roo 100 22 but but CC cord-315656-asvf4roo 100 23 delays delay VBZ cord-315656-asvf4roo 100 24 viral viral JJ cord-315656-asvf4roo 100 25 clearance clearance NN cord-315656-asvf4roo 100 26 ( ( -LRB- cord-315656-asvf4roo 100 27 8 8 CD cord-315656-asvf4roo 100 28 , , , cord-315656-asvf4roo 100 29 55 55 CD cord-315656-asvf4roo 100 30 , , , cord-315656-asvf4roo 100 31 56 56 CD cord-315656-asvf4roo 100 32 ) ) -RRB- cord-315656-asvf4roo 100 33 . . . cord-315656-asvf4roo 101 1 Therefore therefore RB cord-315656-asvf4roo 101 2 , , , cord-315656-asvf4roo 101 3 according accord VBG cord-315656-asvf4roo 101 4 to to IN cord-315656-asvf4roo 101 5 the the DT cord-315656-asvf4roo 101 6 WHO who WP cord-315656-asvf4roo 101 7 's 's POS cord-315656-asvf4roo 101 8 interim interim JJ cord-315656-asvf4roo 101 9 guidelines guideline NNS cord-315656-asvf4roo 101 10 , , , cord-315656-asvf4roo 101 11 corticosteroids corticosteroid NNS cord-315656-asvf4roo 101 12 should should MD cord-315656-asvf4roo 101 13 not not RB cord-315656-asvf4roo 101 14 be be VB cord-315656-asvf4roo 101 15 routinely routinely RB cord-315656-asvf4roo 101 16 given give VBN cord-315656-asvf4roo 101 17 systemically systemically RB cord-315656-asvf4roo 101 18 . . . cord-315656-asvf4roo 102 1 It -PRON- PRP cord-315656-asvf4roo 102 2 is be VBZ cord-315656-asvf4roo 102 3 noteworthy noteworthy JJ cord-315656-asvf4roo 102 4 that that IN cord-315656-asvf4roo 102 5 , , , cord-315656-asvf4roo 102 6 IL-6 IL-6 NNP cord-315656-asvf4roo 102 7 , , , cord-315656-asvf4roo 102 8 one one CD cord-315656-asvf4roo 102 9 of of IN cord-315656-asvf4roo 102 10 the the DT cord-315656-asvf4roo 102 11 cytokines cytokine NNS cord-315656-asvf4roo 102 12 elevated elevate VBN cord-315656-asvf4roo 102 13 in in IN cord-315656-asvf4roo 102 14 response response NN cord-315656-asvf4roo 102 15 to to IN cord-315656-asvf4roo 102 16 SARS SARS NNP cord-315656-asvf4roo 102 17 - - HYPH cord-315656-asvf4roo 102 18 CoV-2 CoV-2 NNP cord-315656-asvf4roo 102 19 was be VBD cord-315656-asvf4roo 102 20 the the DT cord-315656-asvf4roo 102 21 most most RBS cord-315656-asvf4roo 102 22 reported report VBN cord-315656-asvf4roo 102 23 in in IN cord-315656-asvf4roo 102 24 multiple multiple JJ cord-315656-asvf4roo 102 25 clinical clinical JJ cord-315656-asvf4roo 102 26 groups group NNS cord-315656-asvf4roo 102 27 . . . cord-315656-asvf4roo 103 1 For for IN cord-315656-asvf4roo 103 2 instance instance NN cord-315656-asvf4roo 103 3 , , , cord-315656-asvf4roo 103 4 in in IN cord-315656-asvf4roo 103 5 a a DT cord-315656-asvf4roo 103 6 series series NN cord-315656-asvf4roo 103 7 of of IN cord-315656-asvf4roo 103 8 99 99 CD cord-315656-asvf4roo 103 9 COVID-19 covid-19 CD cord-315656-asvf4roo 103 10 cases case NNS cord-315656-asvf4roo 103 11 from from IN cord-315656-asvf4roo 103 12 hospitals hospital NNS cord-315656-asvf4roo 103 13 in in IN cord-315656-asvf4roo 103 14 Wuhan Wuhan NNP cord-315656-asvf4roo 103 15 and and CC cord-315656-asvf4roo 103 16 Shanghai Shanghai NNP cord-315656-asvf4roo 103 17 , , , cord-315656-asvf4roo 103 18 China China NNP cord-315656-asvf4roo 103 19 , , , cord-315656-asvf4roo 103 20 half half NN cord-315656-asvf4roo 103 21 of of IN cord-315656-asvf4roo 103 22 the the DT cord-315656-asvf4roo 103 23 patients patient NNS cord-315656-asvf4roo 103 24 show show VBP cord-315656-asvf4roo 103 25 elevated elevate VBN cord-315656-asvf4roo 103 26 IL-6 IL-6 NNP cord-315656-asvf4roo 103 27 levels level NNS cord-315656-asvf4roo 103 28 ( ( -LRB- cord-315656-asvf4roo 103 29 57 57 CD cord-315656-asvf4roo 103 30 ) ) -RRB- cord-315656-asvf4roo 103 31 . . . cord-315656-asvf4roo 104 1 Another another DT cord-315656-asvf4roo 104 2 group group NN cord-315656-asvf4roo 104 3 investigated investigate VBD cord-315656-asvf4roo 104 4 the the DT cord-315656-asvf4roo 104 5 immune immune JJ cord-315656-asvf4roo 104 6 responses response NNS cord-315656-asvf4roo 104 7 and and CC cord-315656-asvf4roo 104 8 cytokine cytokine NN cord-315656-asvf4roo 104 9 release release NN cord-315656-asvf4roo 104 10 from from IN cord-315656-asvf4roo 104 11 patients patient NNS cord-315656-asvf4roo 104 12 in in IN cord-315656-asvf4roo 104 13 Chongqing Chongqing NNP cord-315656-asvf4roo 104 14 , , , cord-315656-asvf4roo 104 15 China China NNP cord-315656-asvf4roo 104 16 . . . cord-315656-asvf4roo 105 1 They -PRON- PRP cord-315656-asvf4roo 105 2 found find VBD cord-315656-asvf4roo 105 3 that that IN cord-315656-asvf4roo 105 4 IL-6 IL-6 NNP cord-315656-asvf4roo 105 5 was be VBD cord-315656-asvf4roo 105 6 higher high JJR cord-315656-asvf4roo 105 7 in in IN cord-315656-asvf4roo 105 8 76.19 76.19 CD cord-315656-asvf4roo 105 9 % % NN cord-315656-asvf4roo 105 10 of of IN cord-315656-asvf4roo 105 11 severe severe JJ cord-315656-asvf4roo 105 12 patients patient NNS cord-315656-asvf4roo 105 13 , , , cord-315656-asvf4roo 105 14 whereas whereas IN cord-315656-asvf4roo 105 15 that that DT cord-315656-asvf4roo 105 16 was be VBD cord-315656-asvf4roo 105 17 seen see VBN cord-315656-asvf4roo 105 18 in in IN cord-315656-asvf4roo 105 19 only only RB cord-315656-asvf4roo 105 20 30.39 30.39 CD cord-315656-asvf4roo 105 21 % % NN cord-315656-asvf4roo 105 22 of of IN cord-315656-asvf4roo 105 23 mild mild JJ cord-315656-asvf4roo 105 24 patients patient NNS cord-315656-asvf4roo 105 25 ( ( -LRB- cord-315656-asvf4roo 105 26 58 58 CD cord-315656-asvf4roo 105 27 ) ) -RRB- cord-315656-asvf4roo 105 28 . . . cord-315656-asvf4roo 106 1 It -PRON- PRP cord-315656-asvf4roo 106 2 echoes echo VBZ cord-315656-asvf4roo 106 3 that that IN cord-315656-asvf4roo 106 4 the the DT cord-315656-asvf4roo 106 5 elevated elevated JJ cord-315656-asvf4roo 106 6 serum serum NN cord-315656-asvf4roo 106 7 IL-6 IL-6 NNP cord-315656-asvf4roo 106 8 correlates correlate VBZ cord-315656-asvf4roo 106 9 with with IN cord-315656-asvf4roo 106 10 pneumonia pneumonia NN cord-315656-asvf4roo 106 11 , , , cord-315656-asvf4roo 106 12 ARDS ARDS NNP cord-315656-asvf4roo 106 13 , , , cord-315656-asvf4roo 106 14 and and CC cord-315656-asvf4roo 106 15 adverse adverse JJ cord-315656-asvf4roo 106 16 clinical clinical JJ cord-315656-asvf4roo 106 17 outcomes outcome NNS cord-315656-asvf4roo 106 18 ( ( -LRB- cord-315656-asvf4roo 106 19 59 59 CD cord-315656-asvf4roo 106 20 ) ) -RRB- cord-315656-asvf4roo 106 21 ( ( -LRB- cord-315656-asvf4roo 106 22 60 60 CD cord-315656-asvf4roo 106 23 ) ) -RRB- cord-315656-asvf4roo 106 24 ( ( -LRB- cord-315656-asvf4roo 106 25 61 61 CD cord-315656-asvf4roo 106 26 ) ) -RRB- cord-315656-asvf4roo 106 27 . . . cord-315656-asvf4roo 107 1 Elevated elevated JJ cord-315656-asvf4roo 107 2 serum serum NN cord-315656-asvf4roo 107 3 C c NN cord-315656-asvf4roo 107 4 - - HYPH cord-315656-asvf4roo 107 5 reactive reactive JJ cord-315656-asvf4roo 107 6 protein protein NN cord-315656-asvf4roo 107 7 , , , cord-315656-asvf4roo 107 8 which which WDT cord-315656-asvf4roo 107 9 is be VBZ cord-315656-asvf4roo 107 10 regulated regulate VBN cord-315656-asvf4roo 107 11 by by IN cord-315656-asvf4roo 107 12 IL-6 IL-6 NNP cord-315656-asvf4roo 107 13 , , , cord-315656-asvf4roo 107 14 also also RB cord-315656-asvf4roo 107 15 serves serve VBZ cord-315656-asvf4roo 107 16 as as IN cord-315656-asvf4roo 107 17 a a DT cord-315656-asvf4roo 107 18 biomarker biomarker NN cord-315656-asvf4roo 107 19 of of IN cord-315656-asvf4roo 107 20 severe severe JJ cord-315656-asvf4roo 107 21 coronavirus coronavirus NN cord-315656-asvf4roo 107 22 infection infection NN cord-315656-asvf4roo 107 23 ( ( -LRB- cord-315656-asvf4roo 107 24 62 62 CD cord-315656-asvf4roo 107 25 ) ) -RRB- cord-315656-asvf4roo 107 26 . . . cord-315656-asvf4roo 108 1 Based base VBN cord-315656-asvf4roo 108 2 on on IN cord-315656-asvf4roo 108 3 this this DT cord-315656-asvf4roo 108 4 fact fact NN cord-315656-asvf4roo 108 5 , , , cord-315656-asvf4roo 108 6 drugs drug NNS cord-315656-asvf4roo 108 7 such such JJ cord-315656-asvf4roo 108 8 as as IN cord-315656-asvf4roo 108 9 Tocilizumab Tocilizumab NNP cord-315656-asvf4roo 108 10 , , , cord-315656-asvf4roo 108 11 Satralizumab Satralizumab NNP cord-315656-asvf4roo 108 12 , , , cord-315656-asvf4roo 108 13 and and CC cord-315656-asvf4roo 108 14 Sarilumab Sarilumab NNP cord-315656-asvf4roo 108 15 , , , cord-315656-asvf4roo 108 16 as as IN cord-315656-asvf4roo 108 17 IL-6 IL-6 NNP cord-315656-asvf4roo 108 18 receptor receptor NN cord-315656-asvf4roo 108 19 ( ( -LRB- cord-315656-asvf4roo 108 20 IL-6R)-targeted il-6r)-targeted JJ cord-315656-asvf4roo 108 21 monoclonal monoclonal JJ cord-315656-asvf4roo 108 22 antibodies antibody NNS cord-315656-asvf4roo 108 23 ( ( -LRB- cord-315656-asvf4roo 108 24 mAbs mAbs NNP cord-315656-asvf4roo 108 25 ) ) -RRB- cord-315656-asvf4roo 108 26 , , , cord-315656-asvf4roo 108 27 might may MD cord-315656-asvf4roo 108 28 prove prove VB cord-315656-asvf4roo 108 29 beneficial beneficial JJ cord-315656-asvf4roo 108 30 for for IN cord-315656-asvf4roo 108 31 the the DT cord-315656-asvf4roo 108 32 treatment treatment NN cord-315656-asvf4roo 108 33 of of IN cord-315656-asvf4roo 108 34 COVID-19 COVID-19 NNP cord-315656-asvf4roo 108 35 ( ( -LRB- cord-315656-asvf4roo 108 36 63 63 CD cord-315656-asvf4roo 108 37 ) ) -RRB- cord-315656-asvf4roo 108 38 . . . cord-315656-asvf4roo 109 1 Indeed indeed RB cord-315656-asvf4roo 109 2 , , , cord-315656-asvf4roo 109 3 controlled control VBN cord-315656-asvf4roo 109 4 clinical clinical JJ cord-315656-asvf4roo 109 5 trials trial NNS cord-315656-asvf4roo 109 6 are be VBP cord-315656-asvf4roo 109 7 underway underway JJ cord-315656-asvf4roo 109 8 around around IN cord-315656-asvf4roo 109 9 the the DT cord-315656-asvf4roo 109 10 world world NN cord-315656-asvf4roo 109 11 to to TO cord-315656-asvf4roo 109 12 test test VB cord-315656-asvf4roo 109 13 the the DT cord-315656-asvf4roo 109 14 treatment treatment NN cord-315656-asvf4roo 109 15 of of IN cord-315656-asvf4roo 109 16 IL-6 IL-6 NNP cord-315656-asvf4roo 109 17 and and CC cord-315656-asvf4roo 109 18 IL-6R IL-6R NNP cord-315656-asvf4roo 109 19 antagonists antagonist NNS cord-315656-asvf4roo 109 20 for for IN cord-315656-asvf4roo 109 21 COVID-19 covid-19 JJ cord-315656-asvf4roo 109 22 patients patient NNS cord-315656-asvf4roo 109 23 with with IN cord-315656-asvf4roo 109 24 severe severe JJ cord-315656-asvf4roo 109 25 respiratory respiratory JJ cord-315656-asvf4roo 109 26 complications complication NNS cord-315656-asvf4roo 109 27 . . . cord-315656-asvf4roo 110 1 Preliminary preliminary JJ cord-315656-asvf4roo 110 2 results result NNS cord-315656-asvf4roo 110 3 from from IN cord-315656-asvf4roo 110 4 the the DT cord-315656-asvf4roo 110 5 study study NN cord-315656-asvf4roo 110 6 of of IN cord-315656-asvf4roo 110 7 21 21 CD cord-315656-asvf4roo 110 8 severe severe JJ cord-315656-asvf4roo 110 9 COVID-19 covid-19 JJ cord-315656-asvf4roo 110 10 patients patient NNS cord-315656-asvf4roo 110 11 receiving receive VBG cord-315656-asvf4roo 110 12 Tocilizumab Tocilizumab NNP cord-315656-asvf4roo 110 13 in in IN cord-315656-asvf4roo 110 14 Anhui Anhui NNP cord-315656-asvf4roo 110 15 province province NN cord-315656-asvf4roo 110 16 , , , cord-315656-asvf4roo 110 17 China China NNP cord-315656-asvf4roo 110 18 are be VBP cord-315656-asvf4roo 110 19 encouraging encourage VBG cord-315656-asvf4roo 110 20 ( ( -LRB- cord-315656-asvf4roo 110 21 64 64 CD cord-315656-asvf4roo 110 22 ) ) -RRB- cord-315656-asvf4roo 110 23 . . . cord-315656-asvf4roo 111 1 All all DT cord-315656-asvf4roo 111 2 patients patient NNS cord-315656-asvf4roo 111 3 have have VBP cord-315656-asvf4roo 111 4 recovered recover VBN cord-315656-asvf4roo 111 5 from from IN cord-315656-asvf4roo 111 6 fever fever NN cord-315656-asvf4roo 111 7 within within IN cord-315656-asvf4roo 111 8 the the DT cord-315656-asvf4roo 111 9 first first JJ cord-315656-asvf4roo 111 10 day day NN cord-315656-asvf4roo 111 11 of of IN cord-315656-asvf4roo 111 12 Tocilizumab tocilizumab JJ cord-315656-asvf4roo 111 13 treatment treatment NN cord-315656-asvf4roo 111 14 ( ( -LRB- cord-315656-asvf4roo 111 15 64 64 CD cord-315656-asvf4roo 111 16 ) ) -RRB- cord-315656-asvf4roo 111 17 . . . cord-315656-asvf4roo 112 1 Other other JJ cord-315656-asvf4roo 112 2 clinical clinical JJ cord-315656-asvf4roo 112 3 trials trial NNS cord-315656-asvf4roo 112 4 are be VBP cord-315656-asvf4roo 112 5 also also RB cord-315656-asvf4roo 112 6 underway underway JJ cord-315656-asvf4roo 112 7 in in IN cord-315656-asvf4roo 112 8 different different JJ cord-315656-asvf4roo 112 9 countries country NNS cord-315656-asvf4roo 112 10 . . . cord-315656-asvf4roo 113 1 Although although IN cord-315656-asvf4roo 113 2 the the DT cord-315656-asvf4roo 113 3 efficacy efficacy NN cord-315656-asvf4roo 113 4 of of IN cord-315656-asvf4roo 113 5 Tocilizumab Tocilizumab NNP cord-315656-asvf4roo 113 6 in in IN cord-315656-asvf4roo 113 7 COVID-19 covid-19 JJ cord-315656-asvf4roo 113 8 patients patient NNS cord-315656-asvf4roo 113 9 with with IN cord-315656-asvf4roo 113 10 ARDS ARDS NNP cord-315656-asvf4roo 113 11 requires require VBZ cord-315656-asvf4roo 113 12 further further JJ cord-315656-asvf4roo 113 13 evaluation evaluation NN cord-315656-asvf4roo 113 14 in in IN cord-315656-asvf4roo 113 15 a a DT cord-315656-asvf4roo 113 16 larger large JJR cord-315656-asvf4roo 113 17 randomized randomize VBN cord-315656-asvf4roo 113 18 controlled control VBN cord-315656-asvf4roo 113 19 trial trial NN cord-315656-asvf4roo 113 20 , , , cord-315656-asvf4roo 113 21 this this DT cord-315656-asvf4roo 113 22 encouraging encourage VBG cord-315656-asvf4roo 113 23 clinical clinical JJ cord-315656-asvf4roo 113 24 trial trial NN cord-315656-asvf4roo 113 25 suggests suggest VBZ cord-315656-asvf4roo 113 26 that that IN cord-315656-asvf4roo 113 27 neutralizing neutralize VBG cord-315656-asvf4roo 113 28 mAbs mAbs NNP cord-315656-asvf4roo 113 29 against against IN cord-315656-asvf4roo 113 30 other other JJ cord-315656-asvf4roo 113 31 pro pro JJ cord-315656-asvf4roo 113 32 - - JJ cord-315656-asvf4roo 113 33 inflammatory inflammatory JJ cord-315656-asvf4roo 113 34 cytokines cytokine NNS cord-315656-asvf4roo 113 35 such such JJ cord-315656-asvf4roo 113 36 as as IN cord-315656-asvf4roo 113 37 IL-1 IL-1 NNP cord-315656-asvf4roo 113 38 and and CC cord-315656-asvf4roo 113 39 IL-17 IL-17 NNP cord-315656-asvf4roo 113 40 might may MD cord-315656-asvf4roo 113 41 also also RB cord-315656-asvf4roo 113 42 be be VB cord-315656-asvf4roo 113 43 useful useful JJ cord-315656-asvf4roo 113 44 ( ( -LRB- cord-315656-asvf4roo 113 45 54 54 CD cord-315656-asvf4roo 113 46 ) ) -RRB- cord-315656-asvf4roo 113 47 . . . cord-315656-asvf4roo 114 1 For for IN cord-315656-asvf4roo 114 2 urgently urgently RB cord-315656-asvf4roo 114 3 treating treat VBG cord-315656-asvf4roo 114 4 the the DT cord-315656-asvf4roo 114 5 soaring soar VBG cord-315656-asvf4roo 114 6 number number NN cord-315656-asvf4roo 114 7 of of IN cord-315656-asvf4roo 114 8 severe severe JJ cord-315656-asvf4roo 114 9 patients patient NNS cord-315656-asvf4roo 114 10 , , , cord-315656-asvf4roo 114 11 the the DT cord-315656-asvf4roo 114 12 Chinese Chinese NNP cord-315656-asvf4roo 114 13 Diagnosis Diagnosis NNP cord-315656-asvf4roo 114 14 and and CC cord-315656-asvf4roo 114 15 Treatment Treatment NNP cord-315656-asvf4roo 114 16 Protocol Protocol NNP cord-315656-asvf4roo 114 17 for for IN cord-315656-asvf4roo 114 18 2019 2019 CD cord-315656-asvf4roo 114 19 Novel Novel NNP cord-315656-asvf4roo 114 20 Coronavirus Coronavirus NNP cord-315656-asvf4roo 114 21 Pneumonia Pneumonia NNP cord-315656-asvf4roo 114 22 ( ( -LRB- cord-315656-asvf4roo 114 23 The the DT cord-315656-asvf4roo 114 24 7th 7th JJ cord-315656-asvf4roo 114 25 Trial Trial NNP cord-315656-asvf4roo 114 26 Edition Edition NNP cord-315656-asvf4roo 114 27 ) ) -RRB- cord-315656-asvf4roo 114 28 has have VBZ cord-315656-asvf4roo 114 29 updated update VBN cord-315656-asvf4roo 114 30 a a DT cord-315656-asvf4roo 114 31 guideline guideline NN cord-315656-asvf4roo 114 32 for for IN cord-315656-asvf4roo 114 33 taking take VBG cord-315656-asvf4roo 114 34 immunotherapy immunotherapy NN cord-315656-asvf4roo 114 35 : : : cord-315656-asvf4roo 114 36 for for IN cord-315656-asvf4roo 114 37 patients patient NNS cord-315656-asvf4roo 114 38 with with IN cord-315656-asvf4roo 114 39 extensive extensive JJ cord-315656-asvf4roo 114 40 lung lung NN cord-315656-asvf4roo 114 41 lesions lesion NNS cord-315656-asvf4roo 114 42 and and CC cord-315656-asvf4roo 114 43 severe severe JJ cord-315656-asvf4roo 114 44 cases case NNS cord-315656-asvf4roo 114 45 who who WP cord-315656-asvf4roo 114 46 also also RB cord-315656-asvf4roo 114 47 show show VBP cord-315656-asvf4roo 114 48 an an DT cord-315656-asvf4roo 114 49 increased increase VBN cord-315656-asvf4roo 114 50 level level NN cord-315656-asvf4roo 114 51 of of IN cord-315656-asvf4roo 114 52 IL-6 IL-6 NNP cord-315656-asvf4roo 114 53 in in IN cord-315656-asvf4roo 114 54 laboratory laboratory NN cord-315656-asvf4roo 114 55 testing testing NN cord-315656-asvf4roo 114 56 , , , cord-315656-asvf4roo 114 57 Tocilizumab Tocilizumab NNP cord-315656-asvf4roo 114 58 can can MD cord-315656-asvf4roo 114 59 be be VB cord-315656-asvf4roo 114 60 used use VBN cord-315656-asvf4roo 114 61 for for IN cord-315656-asvf4roo 114 62 treatment treatment NN cord-315656-asvf4roo 114 63 . . . cord-315656-asvf4roo 115 1 Although although IN cord-315656-asvf4roo 115 2 with with IN cord-315656-asvf4roo 115 3 exciting exciting JJ cord-315656-asvf4roo 115 4 benefits benefit NNS cord-315656-asvf4roo 115 5 , , , cord-315656-asvf4roo 115 6 the the DT cord-315656-asvf4roo 115 7 inhibition inhibition NN cord-315656-asvf4roo 115 8 of of IN cord-315656-asvf4roo 115 9 IL-6 IL-6 NNP cord-315656-asvf4roo 115 10 pathway pathway NN cord-315656-asvf4roo 115 11 works work VBZ cord-315656-asvf4roo 115 12 mostly mostly RB cord-315656-asvf4roo 115 13 for for IN cord-315656-asvf4roo 115 14 severe severe JJ cord-315656-asvf4roo 115 15 cases case NNS cord-315656-asvf4roo 115 16 , , , cord-315656-asvf4roo 115 17 the the DT cord-315656-asvf4roo 115 18 long long JJ cord-315656-asvf4roo 115 19 - - HYPH cord-315656-asvf4roo 115 20 term term NN cord-315656-asvf4roo 115 21 treatment treatment NN cord-315656-asvf4roo 115 22 strategy strategy NN cord-315656-asvf4roo 115 23 against against IN cord-315656-asvf4roo 115 24 the the DT cord-315656-asvf4roo 115 25 SARS SARS NNP cord-315656-asvf4roo 115 26 - - HYPH cord-315656-asvf4roo 115 27 CoV-2 CoV-2 NNP cord-315656-asvf4roo 115 28 infection infection NN cord-315656-asvf4roo 115 29 requires require VBZ cord-315656-asvf4roo 115 30 the the DT cord-315656-asvf4roo 115 31 rapid rapid JJ cord-315656-asvf4roo 115 32 development development NN cord-315656-asvf4roo 115 33 of of IN cord-315656-asvf4roo 115 34 effective effective JJ cord-315656-asvf4roo 115 35 anti anti JJ cord-315656-asvf4roo 115 36 - - JJ cord-315656-asvf4roo 115 37 viral viral JJ cord-315656-asvf4roo 115 38 drugs drug NNS cord-315656-asvf4roo 115 39 and and CC cord-315656-asvf4roo 115 40 , , , cord-315656-asvf4roo 115 41 more more RBR cord-315656-asvf4roo 115 42 importantly importantly RB cord-315656-asvf4roo 115 43 , , , cord-315656-asvf4roo 115 44 vaccines vaccine NNS cord-315656-asvf4roo 115 45 . . . cord-315656-asvf4roo 116 1 The the DT cord-315656-asvf4roo 116 2 systemic systemic JJ cord-315656-asvf4roo 116 3 cytokine cytokine NN cord-315656-asvf4roo 116 4 storm storm NN cord-315656-asvf4roo 116 5 caused cause VBD cord-315656-asvf4roo 116 6 the the DT cord-315656-asvf4roo 116 7 multiple multiple JJ cord-315656-asvf4roo 116 8 organ organ NN cord-315656-asvf4roo 116 9 failure failure NN cord-315656-asvf4roo 116 10 , , , cord-315656-asvf4roo 116 11 and and CC cord-315656-asvf4roo 116 12 unsurprisingly unsurprisingly RB cord-315656-asvf4roo 116 13 triggered trigger VBD cord-315656-asvf4roo 116 14 the the DT cord-315656-asvf4roo 116 15 hyperinflammatory hyperinflammatory NNP cord-315656-asvf4roo 116 16 responses response NNS cord-315656-asvf4roo 116 17 Frontiers Frontiers NNPS cord-315656-asvf4roo 116 18 in in IN cord-315656-asvf4roo 116 19 Neurology Neurology NNP cord-315656-asvf4roo 116 20 | | NNP cord-315656-asvf4roo 116 21 www.frontiersin.org www.frontiersin.org NN cord-315656-asvf4roo 116 22 inside inside IN cord-315656-asvf4roo 116 23 the the DT cord-315656-asvf4roo 116 24 CNS CNS NNP cord-315656-asvf4roo 116 25 that that WDT cord-315656-asvf4roo 116 26 further further RB cord-315656-asvf4roo 116 27 exacerbated exacerbate VBD cord-315656-asvf4roo 116 28 the the DT cord-315656-asvf4roo 116 29 neurological neurological JJ cord-315656-asvf4roo 116 30 pathology pathology NN cord-315656-asvf4roo 116 31 . . . cord-315656-asvf4roo 117 1 The the DT cord-315656-asvf4roo 117 2 spreading spreading NN cord-315656-asvf4roo 117 3 of of IN cord-315656-asvf4roo 117 4 infected infected JJ cord-315656-asvf4roo 117 5 leukocytes leukocyte NNS cord-315656-asvf4roo 117 6 might may MD cord-315656-asvf4roo 117 7 across across IN cord-315656-asvf4roo 117 8 the the DT cord-315656-asvf4roo 117 9 compromised compromise VBN cord-315656-asvf4roo 117 10 BBB BBB NNP cord-315656-asvf4roo 117 11 , , , cord-315656-asvf4roo 117 12 caused cause VBN cord-315656-asvf4roo 117 13 by by IN cord-315656-asvf4roo 117 14 increased increase VBN cord-315656-asvf4roo 117 15 pro pro JJ cord-315656-asvf4roo 117 16 - - JJ cord-315656-asvf4roo 117 17 inflammatory inflammatory JJ cord-315656-asvf4roo 117 18 cytokines cytokine NNS cord-315656-asvf4roo 117 19 , , , cord-315656-asvf4roo 117 20 from from IN cord-315656-asvf4roo 117 21 the the DT cord-315656-asvf4roo 117 22 periphery periphery NN cord-315656-asvf4roo 117 23 to to IN cord-315656-asvf4roo 117 24 the the DT cord-315656-asvf4roo 117 25 brain brain NN cord-315656-asvf4roo 117 26 . . . cord-315656-asvf4roo 118 1 Previously previously RB cord-315656-asvf4roo 118 2 , , , cord-315656-asvf4roo 118 3 for for IN cord-315656-asvf4roo 118 4 most most JJS cord-315656-asvf4roo 118 5 cases case NNS cord-315656-asvf4roo 118 6 of of IN cord-315656-asvf4roo 118 7 SARS SARS NNP cord-315656-asvf4roo 118 8 , , , cord-315656-asvf4roo 118 9 autopsy autopsy JJ cord-315656-asvf4roo 118 10 detections detection NNS cord-315656-asvf4roo 118 11 of of IN cord-315656-asvf4roo 118 12 affected affected JJ cord-315656-asvf4roo 118 13 brain brain NN cord-315656-asvf4roo 118 14 tissue tissue NN cord-315656-asvf4roo 118 15 samples sample NNS cord-315656-asvf4roo 118 16 have have VBP cord-315656-asvf4roo 118 17 shown show VBN cord-315656-asvf4roo 118 18 signs sign NNS cord-315656-asvf4roo 118 19 of of IN cord-315656-asvf4roo 118 20 extensive extensive JJ cord-315656-asvf4roo 118 21 edema edema NN cord-315656-asvf4roo 118 22 , , , cord-315656-asvf4roo 118 23 microglial microglial JJ cord-315656-asvf4roo 118 24 hyperplasia hyperplasia NN cord-315656-asvf4roo 118 25 , , , cord-315656-asvf4roo 118 26 neuron neuron NN cord-315656-asvf4roo 118 27 necrosis necrosis NN cord-315656-asvf4roo 118 28 , , , cord-315656-asvf4roo 118 29 nerve nerve NN cord-315656-asvf4roo 118 30 demyelination demyelination NN cord-315656-asvf4roo 118 31 , , , cord-315656-asvf4roo 118 32 as as RB cord-315656-asvf4roo 118 33 well well RB cord-315656-asvf4roo 118 34 as as IN cord-315656-asvf4roo 118 35 massive massive JJ cord-315656-asvf4roo 118 36 infiltration infiltration NN cord-315656-asvf4roo 118 37 of of IN cord-315656-asvf4roo 118 38 monocytes monocyte NNS cord-315656-asvf4roo 118 39 and and CC cord-315656-asvf4roo 118 40 lymphocytes lymphocyte NNS cord-315656-asvf4roo 118 41 ( ( -LRB- cord-315656-asvf4roo 118 42 65 65 CD cord-315656-asvf4roo 118 43 ) ) -RRB- cord-315656-asvf4roo 118 44 . . . cord-315656-asvf4roo 119 1 Based base VBN cord-315656-asvf4roo 119 2 on on IN cord-315656-asvf4roo 119 3 recent recent JJ cord-315656-asvf4roo 119 4 autopsy autopsy JJ cord-315656-asvf4roo 119 5 results result NNS cord-315656-asvf4roo 119 6 , , , cord-315656-asvf4roo 119 7 brain brain NN cord-315656-asvf4roo 119 8 hyperemia hyperemia NN cord-315656-asvf4roo 119 9 and and CC cord-315656-asvf4roo 119 10 edema edema NN cord-315656-asvf4roo 119 11 , , , cord-315656-asvf4roo 119 12 partial partial JJ cord-315656-asvf4roo 119 13 neuron neuron NN cord-315656-asvf4roo 119 14 degeneration degeneration NN cord-315656-asvf4roo 119 15 , , , cord-315656-asvf4roo 119 16 as as RB cord-315656-asvf4roo 119 17 well well RB cord-315656-asvf4roo 119 18 as as IN cord-315656-asvf4roo 119 19 inflammatory inflammatory JJ cord-315656-asvf4roo 119 20 cell cell NN cord-315656-asvf4roo 119 21 infiltration infiltration NN cord-315656-asvf4roo 119 22 in in IN cord-315656-asvf4roo 119 23 perivascular perivascular JJ cord-315656-asvf4roo 119 24 regions region NNS cord-315656-asvf4roo 119 25 were be VBD cord-315656-asvf4roo 119 26 also also RB cord-315656-asvf4roo 119 27 detected detect VBN cord-315656-asvf4roo 119 28 in in IN cord-315656-asvf4roo 119 29 COVID-19 covid-19 JJ cord-315656-asvf4roo 119 30 patients patient NNS cord-315656-asvf4roo 119 31 from from IN cord-315656-asvf4roo 119 32 China China NNP cord-315656-asvf4roo 119 33 ( ( -LRB- cord-315656-asvf4roo 119 34 66 66 CD cord-315656-asvf4roo 119 35 ) ) -RRB- cord-315656-asvf4roo 119 36 . . . cord-315656-asvf4roo 120 1 The the DT cord-315656-asvf4roo 120 2 persistence persistence NN cord-315656-asvf4roo 120 3 of of IN cord-315656-asvf4roo 120 4 coronavirus coronavirus NN cord-315656-asvf4roo 120 5 infection infection NN cord-315656-asvf4roo 120 6 and and CC cord-315656-asvf4roo 120 7 its -PRON- PRP$ cord-315656-asvf4roo 120 8 ability ability NN cord-315656-asvf4roo 120 9 to to TO cord-315656-asvf4roo 120 10 infect infect VB cord-315656-asvf4roo 120 11 macrophages macrophage NNS cord-315656-asvf4roo 120 12 , , , cord-315656-asvf4roo 120 13 microglia microglia NN cord-315656-asvf4roo 120 14 , , , cord-315656-asvf4roo 120 15 and and CC cord-315656-asvf4roo 120 16 astrocytes astrocyte NNS cord-315656-asvf4roo 120 17 in in IN cord-315656-asvf4roo 120 18 the the DT cord-315656-asvf4roo 120 19 CNS CNS NNP cord-315656-asvf4roo 120 20 are be VBP cord-315656-asvf4roo 120 21 particularly particularly RB cord-315656-asvf4roo 120 22 critical critical JJ cord-315656-asvf4roo 120 23 in in IN cord-315656-asvf4roo 120 24 the the DT cord-315656-asvf4roo 120 25 pathogenesis pathogenesis NN cord-315656-asvf4roo 120 26 of of IN cord-315656-asvf4roo 120 27 encephalitis encephalitis NN cord-315656-asvf4roo 120 28 ( ( -LRB- cord-315656-asvf4roo 120 29 30 30 CD cord-315656-asvf4roo 120 30 ) ) -RRB- cord-315656-asvf4roo 120 31 . . . cord-315656-asvf4roo 121 1 Notably notably RB cord-315656-asvf4roo 121 2 , , , cord-315656-asvf4roo 121 3 a a DT cord-315656-asvf4roo 121 4 neurotropic neurotropic NNP cord-315656-asvf4roo 121 5 virus virus NN cord-315656-asvf4roo 121 6 could could MD cord-315656-asvf4roo 121 7 directly directly RB cord-315656-asvf4roo 121 8 activate activate VB cord-315656-asvf4roo 121 9 glial glial JJ cord-315656-asvf4roo 121 10 cells cell NNS cord-315656-asvf4roo 121 11 and and CC cord-315656-asvf4roo 121 12 induce induce VB cord-315656-asvf4roo 121 13 a a DT cord-315656-asvf4roo 121 14 pro pro JJ cord-315656-asvf4roo 121 15 - - JJ cord-315656-asvf4roo 121 16 inflammatory inflammatory JJ cord-315656-asvf4roo 121 17 phenotype phenotype NN cord-315656-asvf4roo 121 18 ( ( -LRB- cord-315656-asvf4roo 121 19 67 67 CD cord-315656-asvf4roo 121 20 ) ) -RRB- cord-315656-asvf4roo 121 21 . . . cord-315656-asvf4roo 122 1 Studies study NNS cord-315656-asvf4roo 122 2 have have VBP cord-315656-asvf4roo 122 3 confirmed confirm VBN cord-315656-asvf4roo 122 4 that that IN cord-315656-asvf4roo 122 5 primary primary JJ cord-315656-asvf4roo 122 6 glial glial NN cord-315656-asvf4roo 122 7 cells cell NNS cord-315656-asvf4roo 122 8 cultured culture VBN cord-315656-asvf4roo 122 9 in in IN cord-315656-asvf4roo 122 10 vitro vitro FW cord-315656-asvf4roo 122 11 released release VBD cord-315656-asvf4roo 122 12 a a DT cord-315656-asvf4roo 122 13 large large JJ cord-315656-asvf4roo 122 14 number number NN cord-315656-asvf4roo 122 15 of of IN cord-315656-asvf4roo 122 16 pro pro JJ cord-315656-asvf4roo 122 17 - - JJ cord-315656-asvf4roo 122 18 inflammatory inflammatory JJ cord-315656-asvf4roo 122 19 factors factor NNS cord-315656-asvf4roo 122 20 , , , cord-315656-asvf4roo 122 21 such such JJ cord-315656-asvf4roo 122 22 as as IN cord-315656-asvf4roo 122 23 IL-6 IL-6 NNP cord-315656-asvf4roo 122 24 , , , cord-315656-asvf4roo 122 25 IL-12 IL-12 NNP cord-315656-asvf4roo 122 26 , , , cord-315656-asvf4roo 122 27 IL-15 IL-15 NNP cord-315656-asvf4roo 122 28 , , , cord-315656-asvf4roo 122 29 and and CC cord-315656-asvf4roo 122 30 TNF TNF NNP cord-315656-asvf4roo 122 31 - - HYPH cord-315656-asvf4roo 122 32 α α NNP cord-315656-asvf4roo 122 33 , , , cord-315656-asvf4roo 122 34 upon upon IN cord-315656-asvf4roo 122 35 coronavirus coronavirus NN cord-315656-asvf4roo 122 36 infection infection NN cord-315656-asvf4roo 122 37 ( ( -LRB- cord-315656-asvf4roo 122 38 22 22 CD cord-315656-asvf4roo 122 39 ) ) -RRB- cord-315656-asvf4roo 122 40 . . . cord-315656-asvf4roo 123 1 Glial glial JJ cord-315656-asvf4roo 123 2 cells cell NNS cord-315656-asvf4roo 123 3 , , , cord-315656-asvf4roo 123 4 as as IN cord-315656-asvf4roo 123 5 resident resident JJ cord-315656-asvf4roo 123 6 immune immune JJ cord-315656-asvf4roo 123 7 cells cell NNS cord-315656-asvf4roo 123 8 of of IN cord-315656-asvf4roo 123 9 the the DT cord-315656-asvf4roo 123 10 CNS CNS NNP cord-315656-asvf4roo 123 11 , , , cord-315656-asvf4roo 123 12 normally normally RB cord-315656-asvf4roo 123 13 take take VB cord-315656-asvf4roo 123 14 a a DT cord-315656-asvf4roo 123 15 role role NN cord-315656-asvf4roo 123 16 in in IN cord-315656-asvf4roo 123 17 maintaining maintain VBG cord-315656-asvf4roo 123 18 the the DT cord-315656-asvf4roo 123 19 homeostasis homeostasis NN cord-315656-asvf4roo 123 20 , , , cord-315656-asvf4roo 123 21 responding respond VBG cord-315656-asvf4roo 123 22 promptly promptly RB cord-315656-asvf4roo 123 23 to to IN cord-315656-asvf4roo 123 24 CNS CNS NNP cord-315656-asvf4roo 123 25 injuries injury NNS cord-315656-asvf4roo 123 26 such such JJ cord-315656-asvf4roo 123 27 as as IN cord-315656-asvf4roo 123 28 trauma trauma NN cord-315656-asvf4roo 123 29 , , , cord-315656-asvf4roo 123 30 ischemia ischemia NN cord-315656-asvf4roo 123 31 , , , cord-315656-asvf4roo 123 32 and and CC cord-315656-asvf4roo 123 33 infection infection NN cord-315656-asvf4roo 123 34 , , , cord-315656-asvf4roo 123 35 and and CC cord-315656-asvf4roo 123 36 also also RB cord-315656-asvf4roo 123 37 providing provide VBG cord-315656-asvf4roo 123 38 support support NN cord-315656-asvf4roo 123 39 and and CC cord-315656-asvf4roo 123 40 protection protection NN cord-315656-asvf4roo 123 41 for for IN cord-315656-asvf4roo 123 42 neurons neuron NNS cord-315656-asvf4roo 123 43 . . . cord-315656-asvf4roo 124 1 Particularly particularly RB cord-315656-asvf4roo 124 2 , , , cord-315656-asvf4roo 124 3 microglia microglia NNS cord-315656-asvf4roo 124 4 are be VBP cord-315656-asvf4roo 124 5 initially initially RB cord-315656-asvf4roo 124 6 activated activate VBN cord-315656-asvf4roo 124 7 to to TO cord-315656-asvf4roo 124 8 clear clear VB cord-315656-asvf4roo 124 9 the the DT cord-315656-asvf4roo 124 10 invaded invade VBN cord-315656-asvf4roo 124 11 pathogens pathogen NNS cord-315656-asvf4roo 124 12 by by IN cord-315656-asvf4roo 124 13 secreting secrete VBG cord-315656-asvf4roo 124 14 pro pro JJ cord-315656-asvf4roo 124 15 - - JJ cord-315656-asvf4roo 124 16 inflammatory inflammatory JJ cord-315656-asvf4roo 124 17 mediators mediator NNS cord-315656-asvf4roo 124 18 , , , cord-315656-asvf4roo 124 19 followed follow VBN cord-315656-asvf4roo 124 20 by by IN cord-315656-asvf4roo 124 21 promoting promote VBG cord-315656-asvf4roo 124 22 tissue tissue NN cord-315656-asvf4roo 124 23 reconstitution reconstitution NN cord-315656-asvf4roo 124 24 and and CC cord-315656-asvf4roo 124 25 inflammation inflammation NN cord-315656-asvf4roo 124 26 resolution resolution NN cord-315656-asvf4roo 124 27 . . . cord-315656-asvf4roo 125 1 Microglia Microglia NNP cord-315656-asvf4roo 125 2 have have VBP cord-315656-asvf4roo 125 3 been be VBN cord-315656-asvf4roo 125 4 demonstrated demonstrate VBN cord-315656-asvf4roo 125 5 to to TO cord-315656-asvf4roo 125 6 protect protect VB cord-315656-asvf4roo 125 7 against against IN cord-315656-asvf4roo 125 8 lethal lethal JJ cord-315656-asvf4roo 125 9 coronavirus coronavirus NN cord-315656-asvf4roo 125 10 encephalitis encephalitis RB cord-315656-asvf4roo 125 11 in in IN cord-315656-asvf4roo 125 12 mice mouse NNS cord-315656-asvf4roo 125 13 ( ( -LRB- cord-315656-asvf4roo 125 14 68 68 CD cord-315656-asvf4roo 125 15 ) ) -RRB- cord-315656-asvf4roo 125 16 . . . cord-315656-asvf4roo 126 1 During during IN cord-315656-asvf4roo 126 2 the the DT cord-315656-asvf4roo 126 3 early early JJ cord-315656-asvf4roo 126 4 days day NNS cord-315656-asvf4roo 126 5 after after IN cord-315656-asvf4roo 126 6 infection infection NN cord-315656-asvf4roo 126 7 , , , cord-315656-asvf4roo 126 8 microglia microglia NNS cord-315656-asvf4roo 126 9 were be VBD cord-315656-asvf4roo 126 10 required require VBN cord-315656-asvf4roo 126 11 to to TO cord-315656-asvf4roo 126 12 limit limit VB cord-315656-asvf4roo 126 13 mouse mouse NN cord-315656-asvf4roo 126 14 hepatitis hepatitis NN cord-315656-asvf4roo 126 15 virus virus NN cord-315656-asvf4roo 126 16 ( ( -LRB- cord-315656-asvf4roo 126 17 MHV mhv NN cord-315656-asvf4roo 126 18 ) ) -RRB- cord-315656-asvf4roo 126 19 replication replication NN cord-315656-asvf4roo 126 20 and and CC cord-315656-asvf4roo 126 21 subsequent subsequent JJ cord-315656-asvf4roo 126 22 morbidity morbidity NN cord-315656-asvf4roo 126 23 and and CC cord-315656-asvf4roo 126 24 lethality lethality NN cord-315656-asvf4roo 126 25 . . . cord-315656-asvf4roo 127 1 The the DT cord-315656-asvf4roo 127 2 chemical chemical NN cord-315656-asvf4roo 127 3 depletion depletion NN cord-315656-asvf4roo 127 4 of of IN cord-315656-asvf4roo 127 5 microglia microglia NN cord-315656-asvf4roo 127 6 led lead VBD cord-315656-asvf4roo 127 7 to to IN cord-315656-asvf4roo 127 8 increased increase VBN cord-315656-asvf4roo 127 9 viral viral JJ cord-315656-asvf4roo 127 10 replication replication NN cord-315656-asvf4roo 127 11 in in IN cord-315656-asvf4roo 127 12 the the DT cord-315656-asvf4roo 127 13 brain brain NN cord-315656-asvf4roo 127 14 and and CC cord-315656-asvf4roo 127 15 caused cause VBD cord-315656-asvf4roo 127 16 ineffective ineffective JJ cord-315656-asvf4roo 127 17 T t NN cord-315656-asvf4roo 127 18 cell cell NN cord-315656-asvf4roo 127 19 responses response NNS cord-315656-asvf4roo 127 20 , , , cord-315656-asvf4roo 127 21 reminiscent reminiscent JJ cord-315656-asvf4roo 127 22 of of IN cord-315656-asvf4roo 127 23 the the DT cord-315656-asvf4roo 127 24 critical critical JJ cord-315656-asvf4roo 127 25 role role NN cord-315656-asvf4roo 127 26 of of IN cord-315656-asvf4roo 127 27 microglia microglia NNS cord-315656-asvf4roo 127 28 in in IN cord-315656-asvf4roo 127 29 the the DT cord-315656-asvf4roo 127 30 early early JJ cord-315656-asvf4roo 127 31 innate innate JJ cord-315656-asvf4roo 127 32 responses response NNS cord-315656-asvf4roo 127 33 to to IN cord-315656-asvf4roo 127 34 virus virus NN cord-315656-asvf4roo 127 35 infections infection NNS cord-315656-asvf4roo 127 36 ( ( -LRB- cord-315656-asvf4roo 127 37 68 68 CD cord-315656-asvf4roo 127 38 ) ) -RRB- cord-315656-asvf4roo 127 39 . . . cord-315656-asvf4roo 128 1 However however RB cord-315656-asvf4roo 128 2 , , , cord-315656-asvf4roo 128 3 in in IN cord-315656-asvf4roo 128 4 addition addition NN cord-315656-asvf4roo 128 5 to to IN cord-315656-asvf4roo 128 6 protective protective JJ cord-315656-asvf4roo 128 7 effects effect NNS cord-315656-asvf4roo 128 8 , , , cord-315656-asvf4roo 128 9 microglia microglia NNS cord-315656-asvf4roo 128 10 may may MD cord-315656-asvf4roo 128 11 also also RB cord-315656-asvf4roo 128 12 mediate mediate VB cord-315656-asvf4roo 128 13 hippocampal hippocampal JJ cord-315656-asvf4roo 128 14 presynaptic presynaptic JJ cord-315656-asvf4roo 128 15 membrane membrane NN cord-315656-asvf4roo 128 16 damage damage NN cord-315656-asvf4roo 128 17 through through IN cord-315656-asvf4roo 128 18 complement complement NN cord-315656-asvf4roo 128 19 system system NN cord-315656-asvf4roo 128 20 , , , cord-315656-asvf4roo 128 21 resulting result VBG cord-315656-asvf4roo 128 22 in in IN cord-315656-asvf4roo 128 23 long long JJ cord-315656-asvf4roo 128 24 - - HYPH cord-315656-asvf4roo 128 25 term term NN cord-315656-asvf4roo 128 26 memory memory NN cord-315656-asvf4roo 128 27 impairment impairment NN cord-315656-asvf4roo 128 28 and and CC cord-315656-asvf4roo 128 29 cognitive cognitive JJ cord-315656-asvf4roo 128 30 decline decline NN cord-315656-asvf4roo 128 31 in in IN cord-315656-asvf4roo 128 32 patients patient NNS cord-315656-asvf4roo 128 33 with with IN cord-315656-asvf4roo 128 34 encephalitis encephalitis NN cord-315656-asvf4roo 128 35 , , , cord-315656-asvf4roo 128 36 caused cause VBN cord-315656-asvf4roo 128 37 by by IN cord-315656-asvf4roo 128 38 coronavirus coronavirus NN cord-315656-asvf4roo 128 39 or or CC cord-315656-asvf4roo 128 40 human human JJ cord-315656-asvf4roo 128 41 immunodeficiency immunodeficiency NN cord-315656-asvf4roo 128 42 virus virus NN cord-315656-asvf4roo 128 43 ( ( -LRB- cord-315656-asvf4roo 128 44 HIV HIV NNP cord-315656-asvf4roo 128 45 ) ) -RRB- cord-315656-asvf4roo 128 46 infection infection NN cord-315656-asvf4roo 128 47 ( ( -LRB- cord-315656-asvf4roo 128 48 69 69 CD cord-315656-asvf4roo 128 49 ) ) -RRB- cord-315656-asvf4roo 128 50 . . . cord-315656-asvf4roo 129 1 Thus thus RB cord-315656-asvf4roo 129 2 , , , cord-315656-asvf4roo 129 3 beyond beyond IN cord-315656-asvf4roo 129 4 the the DT cord-315656-asvf4roo 129 5 acute acute JJ cord-315656-asvf4roo 129 6 cytokine cytokine NN cord-315656-asvf4roo 129 7 storm storm NN cord-315656-asvf4roo 129 8 , , , cord-315656-asvf4roo 129 9 the the DT cord-315656-asvf4roo 129 10 activation activation NN cord-315656-asvf4roo 129 11 of of IN cord-315656-asvf4roo 129 12 immune immune JJ cord-315656-asvf4roo 129 13 cells cell NNS cord-315656-asvf4roo 129 14 in in IN cord-315656-asvf4roo 129 15 the the DT cord-315656-asvf4roo 129 16 brain brain NN cord-315656-asvf4roo 129 17 might may MD cord-315656-asvf4roo 129 18 cause cause VB cord-315656-asvf4roo 129 19 chronic chronic JJ cord-315656-asvf4roo 129 20 inflammation inflammation NN cord-315656-asvf4roo 129 21 and and CC cord-315656-asvf4roo 129 22 brain brain NN cord-315656-asvf4roo 129 23 damages damage NNS cord-315656-asvf4roo 129 24 in in IN cord-315656-asvf4roo 129 25 COVID-19 covid-19 JJ cord-315656-asvf4roo 129 26 patients patient NNS cord-315656-asvf4roo 129 27 . . . cord-315656-asvf4roo 130 1 Taken take VBN cord-315656-asvf4roo 130 2 together together RB cord-315656-asvf4roo 130 3 , , , cord-315656-asvf4roo 130 4 in in IN cord-315656-asvf4roo 130 5 the the DT cord-315656-asvf4roo 130 6 short short JJ cord-315656-asvf4roo 130 7 - - HYPH cord-315656-asvf4roo 130 8 term term NN cord-315656-asvf4roo 130 9 , , , cord-315656-asvf4roo 130 10 SARS SARS NNP cord-315656-asvf4roo 130 11 - - HYPH cord-315656-asvf4roo 130 12 CoV-2 CoV-2 NNP cord-315656-asvf4roo 130 13 infections infection NNS cord-315656-asvf4roo 130 14 may may MD cord-315656-asvf4roo 130 15 cause cause VB cord-315656-asvf4roo 130 16 the the DT cord-315656-asvf4roo 130 17 CNS CNS NNP cord-315656-asvf4roo 130 18 inflammation inflammation NN cord-315656-asvf4roo 130 19 and and CC cord-315656-asvf4roo 130 20 lead lead VB cord-315656-asvf4roo 130 21 to to IN cord-315656-asvf4roo 130 22 encephalitis encephalitis NN cord-315656-asvf4roo 130 23 . . . cord-315656-asvf4roo 131 1 Potential potential JJ cord-315656-asvf4roo 131 2 long long JJ cord-315656-asvf4roo 131 3 - - HYPH cord-315656-asvf4roo 131 4 term term NN cord-315656-asvf4roo 131 5 effects effect NNS cord-315656-asvf4roo 131 6 , , , cord-315656-asvf4roo 131 7 such such JJ cord-315656-asvf4roo 131 8 as as IN cord-315656-asvf4roo 131 9 changes change NNS cord-315656-asvf4roo 131 10 in in IN cord-315656-asvf4roo 131 11 mood mood NN cord-315656-asvf4roo 131 12 and and CC cord-315656-asvf4roo 131 13 cognitive cognitive JJ cord-315656-asvf4roo 131 14 behavior behavior NN cord-315656-asvf4roo 131 15 , , , cord-315656-asvf4roo 131 16 and and CC cord-315656-asvf4roo 131 17 continuous continuous JJ cord-315656-asvf4roo 131 18 changes change NNS cord-315656-asvf4roo 131 19 in in IN cord-315656-asvf4roo 131 20 the the DT cord-315656-asvf4roo 131 21 expression expression NN cord-315656-asvf4roo 131 22 of of IN cord-315656-asvf4roo 131 23 genes gene NNS cord-315656-asvf4roo 131 24 that that WDT cord-315656-asvf4roo 131 25 regulate regulate VBP cord-315656-asvf4roo 131 26 synaptic synaptic JJ cord-315656-asvf4roo 131 27 activity activity NN cord-315656-asvf4roo 131 28 in in IN cord-315656-asvf4roo 131 29 key key JJ cord-315656-asvf4roo 131 30 brain brain NN cord-315656-asvf4roo 131 31 regions region NNS cord-315656-asvf4roo 131 32 should should MD cord-315656-asvf4roo 131 33 not not RB cord-315656-asvf4roo 131 34 be be VB cord-315656-asvf4roo 131 35 neglected neglect VBN cord-315656-asvf4roo 131 36 . . . cord-315656-asvf4roo 132 1 Moreover moreover RB cord-315656-asvf4roo 132 2 , , , cord-315656-asvf4roo 132 3 this this DT cord-315656-asvf4roo 132 4 speculation speculation NN cord-315656-asvf4roo 132 5 has have VBZ cord-315656-asvf4roo 132 6 drawing draw VBG cord-315656-asvf4roo 132 7 increasing increase VBG cord-315656-asvf4roo 132 8 attentions attention NNS cord-315656-asvf4roo 132 9 of of IN cord-315656-asvf4roo 132 10 clinicians clinician NNS cord-315656-asvf4roo 132 11 and and CC cord-315656-asvf4roo 132 12 neuroscientists neuroscientist NNS cord-315656-asvf4roo 132 13 ( ( -LRB- cord-315656-asvf4roo 132 14 21 21 CD cord-315656-asvf4roo 132 15 , , , cord-315656-asvf4roo 132 16 ( ( -LRB- cord-315656-asvf4roo 132 17 70 70 CD cord-315656-asvf4roo 132 18 ) ) -RRB- cord-315656-asvf4roo 132 19 ( ( -LRB- cord-315656-asvf4roo 132 20 71 71 CD cord-315656-asvf4roo 132 21 ) ) -RRB- cord-315656-asvf4roo 132 22 ( ( -LRB- cord-315656-asvf4roo 132 23 72 72 CD cord-315656-asvf4roo 132 24 ) ) -RRB- cord-315656-asvf4roo 132 25 ( ( -LRB- cord-315656-asvf4roo 132 26 73 73 CD cord-315656-asvf4roo 132 27 ) ) -RRB- cord-315656-asvf4roo 132 28 . . . cord-315656-asvf4roo 133 1 Hence hence RB cord-315656-asvf4roo 133 2 , , , cord-315656-asvf4roo 133 3 prognostic prognostic JJ cord-315656-asvf4roo 133 4 research research NN cord-315656-asvf4roo 133 5 on on IN cord-315656-asvf4roo 133 6 potential potential JJ cord-315656-asvf4roo 133 7 and and CC cord-315656-asvf4roo 133 8 longitudinal longitudinal JJ cord-315656-asvf4roo 133 9 potential potential JJ cord-315656-asvf4roo 133 10 COVID-19-related covid-19-related JJ cord-315656-asvf4roo 133 11 neuropsychiatric neuropsychiatric JJ cord-315656-asvf4roo 133 12 diseases disease NNS cord-315656-asvf4roo 133 13 is be VBZ cord-315656-asvf4roo 133 14 crucial crucial JJ cord-315656-asvf4roo 133 15 in in IN cord-315656-asvf4roo 133 16 disease disease NN cord-315656-asvf4roo 133 17 surveillance surveillance NN cord-315656-asvf4roo 133 18 and and CC cord-315656-asvf4roo 133 19 evidence evidence NN cord-315656-asvf4roo 133 20 - - HYPH cord-315656-asvf4roo 133 21 based base VBN cord-315656-asvf4roo 133 22 treatment treatment NN cord-315656-asvf4roo 133 23 strategies strategy NNS cord-315656-asvf4roo 133 24 ( ( -LRB- cord-315656-asvf4roo 133 25 74 74 CD cord-315656-asvf4roo 133 26 ) ) -RRB- cord-315656-asvf4roo 133 27 . . . cord-315656-asvf4roo 134 1 The the DT cord-315656-asvf4roo 134 2 multiple multiple JJ cord-315656-asvf4roo 134 3 organ organ NN cord-315656-asvf4roo 134 4 failure failure NN cord-315656-asvf4roo 134 5 in in IN cord-315656-asvf4roo 134 6 COVID-19 COVID-19 NNP cord-315656-asvf4roo 134 7 is be VBZ cord-315656-asvf4roo 134 8 associated associate VBN cord-315656-asvf4roo 134 9 with with IN cord-315656-asvf4roo 134 10 the the DT cord-315656-asvf4roo 134 11 acute acute JJ cord-315656-asvf4roo 134 12 immune immune JJ cord-315656-asvf4roo 134 13 imbalance imbalance NN cord-315656-asvf4roo 134 14 , , , cord-315656-asvf4roo 134 15 whereas whereas IN cord-315656-asvf4roo 134 16 the the DT cord-315656-asvf4roo 134 17 chronic chronic JJ cord-315656-asvf4roo 134 18 immune immune JJ cord-315656-asvf4roo 134 19 imbalance imbalance NN cord-315656-asvf4roo 134 20 in in IN cord-315656-asvf4roo 134 21 the the DT cord-315656-asvf4roo 134 22 CNS CNS NNP cord-315656-asvf4roo 134 23 , , , cord-315656-asvf4roo 134 24 either either CC cord-315656-asvf4roo 134 25 by by IN cord-315656-asvf4roo 134 26 invaded invade VBN cord-315656-asvf4roo 134 27 virus virus NN cord-315656-asvf4roo 134 28 or or CC cord-315656-asvf4roo 134 29 by by IN cord-315656-asvf4roo 134 30 infiltrated infiltrate VBN cord-315656-asvf4roo 134 31 immune immune JJ cord-315656-asvf4roo 134 32 mediators mediator NNS cord-315656-asvf4roo 134 33 , , , cord-315656-asvf4roo 134 34 might may MD cord-315656-asvf4roo 134 35 be be VB cord-315656-asvf4roo 134 36 happening happen VBG cord-315656-asvf4roo 135 1 ( ( -LRB- cord-315656-asvf4roo 135 2 Figure figure NN cord-315656-asvf4roo 135 3 1 1 CD cord-315656-asvf4roo 135 4 ) ) -RRB- cord-315656-asvf4roo 135 5 . . . cord-315656-asvf4roo 136 1 An an DT cord-315656-asvf4roo 136 2 emerging emerge VBG cord-315656-asvf4roo 136 3 hypothesis hypothesis NN cord-315656-asvf4roo 136 4 states state VBZ cord-315656-asvf4roo 136 5 that that IN cord-315656-asvf4roo 136 6 the the DT cord-315656-asvf4roo 136 7 inflammation inflammation NN cord-315656-asvf4roo 136 8 caused cause VBN cord-315656-asvf4roo 136 9 by by IN cord-315656-asvf4roo 136 10 viral viral JJ cord-315656-asvf4roo 136 11 infection infection NN cord-315656-asvf4roo 136 12 may may MD cord-315656-asvf4roo 136 13 trigger trigger VB cord-315656-asvf4roo 136 14 and and CC cord-315656-asvf4roo 136 15 propagate propagate VB cord-315656-asvf4roo 136 16 chronic chronic JJ cord-315656-asvf4roo 136 17 neuronal neuronal JJ cord-315656-asvf4roo 136 18 dysfunction dysfunction NN cord-315656-asvf4roo 136 19 , , , cord-315656-asvf4roo 136 20 which which WDT cord-315656-asvf4roo 136 21 is be VBZ cord-315656-asvf4roo 136 22 an an DT cord-315656-asvf4roo 136 23 event event NN cord-315656-asvf4roo 136 24 before before IN cord-315656-asvf4roo 136 25 the the DT cord-315656-asvf4roo 136 26 clinical clinical JJ cord-315656-asvf4roo 136 27 onset onset NN cord-315656-asvf4roo 136 28 of of IN cord-315656-asvf4roo 136 29 multiple multiple JJ cord-315656-asvf4roo 136 30 neurodegenerative neurodegenerative JJ cord-315656-asvf4roo 136 31 diseases disease NNS cord-315656-asvf4roo 136 32 such such JJ cord-315656-asvf4roo 136 33 as as IN cord-315656-asvf4roo 136 34 Parkinson Parkinson NNP cord-315656-asvf4roo 136 35 's 's POS cord-315656-asvf4roo 136 36 disease disease NN cord-315656-asvf4roo 136 37 ( ( -LRB- cord-315656-asvf4roo 136 38 PD PD NNP cord-315656-asvf4roo 136 39 ) ) -RRB- cord-315656-asvf4roo 136 40 and and CC cord-315656-asvf4roo 136 41 Alzheimer Alzheimer NNP cord-315656-asvf4roo 136 42 's 's POS cord-315656-asvf4roo 136 43 disease disease NN cord-315656-asvf4roo 136 44 ( ( -LRB- cord-315656-asvf4roo 136 45 AD ad NN cord-315656-asvf4roo 136 46 ) ) -RRB- cord-315656-asvf4roo 137 1 ( ( -LRB- cord-315656-asvf4roo 137 2 75 75 CD cord-315656-asvf4roo 137 3 ) ) -RRB- cord-315656-asvf4roo 137 4 . . . cord-315656-asvf4roo 138 1 Notably notably RB cord-315656-asvf4roo 138 2 , , , cord-315656-asvf4roo 138 3 the the DT cord-315656-asvf4roo 138 4 chronic chronic JJ cord-315656-asvf4roo 138 5 immune immune JJ cord-315656-asvf4roo 138 6 imbalance imbalance NN cord-315656-asvf4roo 138 7 is be VBZ cord-315656-asvf4roo 138 8 the the DT cord-315656-asvf4roo 138 9 shared share VBN cord-315656-asvf4roo 138 10 hallmark hallmark NN cord-315656-asvf4roo 138 11 for for IN cord-315656-asvf4roo 138 12 neuropsychiatric neuropsychiatric JJ cord-315656-asvf4roo 138 13 and and CC cord-315656-asvf4roo 138 14 neurodegenerative neurodegenerative JJ cord-315656-asvf4roo 138 15 diseases disease NNS cord-315656-asvf4roo 138 16 , , , cord-315656-asvf4roo 138 17 due due IN cord-315656-asvf4roo 138 18 to to IN cord-315656-asvf4roo 138 19 the the DT cord-315656-asvf4roo 138 20 uncontrolled uncontrolled JJ cord-315656-asvf4roo 138 21 skewing skewing NN cord-315656-asvf4roo 138 22 of of IN cord-315656-asvf4roo 138 23 glial glial JJ cord-315656-asvf4roo 138 24 phenotypes phenotype NNS cord-315656-asvf4roo 138 25 into into IN cord-315656-asvf4roo 138 26 detrimental detrimental JJ cord-315656-asvf4roo 138 27 states state NNS cord-315656-asvf4roo 138 28 ( ( -LRB- cord-315656-asvf4roo 138 29 76 76 CD cord-315656-asvf4roo 138 30 ) ) -RRB- cord-315656-asvf4roo 138 31 . . . cord-315656-asvf4roo 139 1 Experimental experimental JJ cord-315656-asvf4roo 139 2 vaccination vaccination NN cord-315656-asvf4roo 139 3 of of IN cord-315656-asvf4roo 139 4 mice mouse NNS cord-315656-asvf4roo 139 5 with with IN cord-315656-asvf4roo 139 6 H5N1 H5N1 NNP cord-315656-asvf4roo 139 7 influenza influenza NN cord-315656-asvf4roo 139 8 virus virus NN cord-315656-asvf4roo 139 9 can can MD cord-315656-asvf4roo 139 10 mimic mimic VB cord-315656-asvf4roo 139 11 many many JJ cord-315656-asvf4roo 139 12 aspects aspect NNS cord-315656-asvf4roo 139 13 of of IN cord-315656-asvf4roo 139 14 PD PD NNP cord-315656-asvf4roo 139 15 - - HYPH cord-315656-asvf4roo 139 16 like like JJ cord-315656-asvf4roo 139 17 initiation initiation NN cord-315656-asvf4roo 139 18 and and CC cord-315656-asvf4roo 139 19 pathogenesis pathogenesis NN cord-315656-asvf4roo 139 20 ( ( -LRB- cord-315656-asvf4roo 139 21 77 77 CD cord-315656-asvf4roo 139 22 , , , cord-315656-asvf4roo 139 23 78 78 CD cord-315656-asvf4roo 139 24 ) ) -RRB- cord-315656-asvf4roo 139 25 . . . cord-315656-asvf4roo 140 1 The the DT cord-315656-asvf4roo 140 2 continued continued JJ cord-315656-asvf4roo 140 3 inflammation inflammation NN cord-315656-asvf4roo 140 4 that that WDT cord-315656-asvf4roo 140 5 follows follow VBZ cord-315656-asvf4roo 140 6 in in IN cord-315656-asvf4roo 140 7 the the DT cord-315656-asvf4roo 140 8 viral viral JJ cord-315656-asvf4roo 140 9 trajectory trajectory NN cord-315656-asvf4roo 140 10 leads lead VBZ cord-315656-asvf4roo 140 11 to to IN cord-315656-asvf4roo 140 12 dysfunction dysfunction NN cord-315656-asvf4roo 140 13 or or CC cord-315656-asvf4roo 140 14 degeneration degeneration NN cord-315656-asvf4roo 140 15 of of IN cord-315656-asvf4roo 140 16 dopaminergic dopaminergic JJ cord-315656-asvf4roo 140 17 neurons neuron NNS cord-315656-asvf4roo 140 18 in in IN cord-315656-asvf4roo 140 19 the the DT cord-315656-asvf4roo 140 20 midbrain midbrain NN cord-315656-asvf4roo 140 21 , , , cord-315656-asvf4roo 140 22 just just RB cord-315656-asvf4roo 140 23 as as IN cord-315656-asvf4roo 140 24 seen see VBN cord-315656-asvf4roo 140 25 in in IN cord-315656-asvf4roo 140 26 PD PD NNP cord-315656-asvf4roo 140 27 patients patient NNS cord-315656-asvf4roo 140 28 ( ( -LRB- cord-315656-asvf4roo 140 29 77 77 CD cord-315656-asvf4roo 140 30 , , , cord-315656-asvf4roo 140 31 78 78 CD cord-315656-asvf4roo 140 32 ) ) -RRB- cord-315656-asvf4roo 140 33 . . . cord-315656-asvf4roo 141 1 Therefore therefore RB cord-315656-asvf4roo 141 2 , , , cord-315656-asvf4roo 141 3 it -PRON- PRP cord-315656-asvf4roo 141 4 would would MD cord-315656-asvf4roo 141 5 be be VB cord-315656-asvf4roo 141 6 interesting interesting JJ cord-315656-asvf4roo 141 7 to to TO cord-315656-asvf4roo 141 8 probe probe VB cord-315656-asvf4roo 141 9 the the DT cord-315656-asvf4roo 141 10 relationship relationship NN cord-315656-asvf4roo 141 11 between between IN cord-315656-asvf4roo 141 12 the the DT cord-315656-asvf4roo 141 13 immune immune JJ cord-315656-asvf4roo 141 14 responses response NNS cord-315656-asvf4roo 141 15 upon upon IN cord-315656-asvf4roo 141 16 coronavirus coronavirus NN cord-315656-asvf4roo 141 17 infections infection NNS cord-315656-asvf4roo 141 18 and and CC cord-315656-asvf4roo 141 19 neurodegeneration/ neurodegeneration/ CD cord-315656-asvf4roo 141 20 neuropsychiatric neuropsychiatric JJ cord-315656-asvf4roo 141 21 impairments impairment NNS cord-315656-asvf4roo 141 22 . . . cord-315656-asvf4roo 142 1 The the DT cord-315656-asvf4roo 142 2 similar similar JJ cord-315656-asvf4roo 142 3 set set NN cord-315656-asvf4roo 142 4 of of IN cord-315656-asvf4roo 142 5 sustained sustained JJ cord-315656-asvf4roo 142 6 elevated elevated JJ cord-315656-asvf4roo 142 7 pro pro JJ cord-315656-asvf4roo 142 8 - - JJ cord-315656-asvf4roo 142 9 inflammatory inflammatory JJ cord-315656-asvf4roo 142 10 cytokines cytokine NNS cord-315656-asvf4roo 142 11 or or CC cord-315656-asvf4roo 142 12 chemokines chemokine NNS cord-315656-asvf4roo 142 13 , , , cord-315656-asvf4roo 142 14 typically typically RB cord-315656-asvf4roo 142 15 ILs ILs NNP cord-315656-asvf4roo 142 16 , , , cord-315656-asvf4roo 142 17 CXCLs CXCLs NNP cord-315656-asvf4roo 142 18 , , , cord-315656-asvf4roo 142 19 and and CC cord-315656-asvf4roo 142 20 TNF TNF NNP cord-315656-asvf4roo 142 21 , , , cord-315656-asvf4roo 142 22 that that DT cord-315656-asvf4roo 142 23 trigger trigger VBP cord-315656-asvf4roo 142 24 the the DT cord-315656-asvf4roo 142 25 cytokine cytokine NN cord-315656-asvf4roo 142 26 storm storm NN cord-315656-asvf4roo 142 27 of of IN cord-315656-asvf4roo 142 28 COVID-19 COVID-19 NNP cord-315656-asvf4roo 142 29 are be VBP cord-315656-asvf4roo 142 30 also also RB cord-315656-asvf4roo 142 31 frequently frequently RB cord-315656-asvf4roo 142 32 detected detect VBN cord-315656-asvf4roo 142 33 in in IN cord-315656-asvf4roo 142 34 the the DT cord-315656-asvf4roo 142 35 CSF csf NN cord-315656-asvf4roo 142 36 and and CC cord-315656-asvf4roo 142 37 autopsy autopsy JJ cord-315656-asvf4roo 142 38 brain brain NN cord-315656-asvf4roo 142 39 samples sample NNS cord-315656-asvf4roo 142 40 ( ( -LRB- cord-315656-asvf4roo 142 41 79 79 CD cord-315656-asvf4roo 142 42 ) ) -RRB- cord-315656-asvf4roo 142 43 ( ( -LRB- cord-315656-asvf4roo 142 44 80 80 CD cord-315656-asvf4roo 142 45 ) ) -RRB- cord-315656-asvf4roo 142 46 ( ( -LRB- cord-315656-asvf4roo 142 47 81 81 CD cord-315656-asvf4roo 142 48 ) ) -RRB- cord-315656-asvf4roo 142 49 , , , cord-315656-asvf4roo 142 50 which which WDT cord-315656-asvf4roo 142 51 is be VBZ cord-315656-asvf4roo 142 52 critical critical JJ cord-315656-asvf4roo 142 53 in in IN cord-315656-asvf4roo 142 54 the the DT cord-315656-asvf4roo 142 55 development development NN cord-315656-asvf4roo 142 56 and and CC cord-315656-asvf4roo 142 57 progression progression NN cord-315656-asvf4roo 142 58 of of IN cord-315656-asvf4roo 142 59 numerous numerous JJ cord-315656-asvf4roo 142 60 neurodegenerative neurodegenerative JJ cord-315656-asvf4roo 142 61 disorders disorder NNS cord-315656-asvf4roo 142 62 . . . cord-315656-asvf4roo 143 1 Since since IN cord-315656-asvf4roo 143 2 the the DT cord-315656-asvf4roo 143 3 role role NN cord-315656-asvf4roo 143 4 of of IN cord-315656-asvf4roo 143 5 neuroinflammation neuroinflammation NN cord-315656-asvf4roo 143 6 and and CC cord-315656-asvf4roo 143 7 specific specific JJ cord-315656-asvf4roo 143 8 inflammatory inflammatory JJ cord-315656-asvf4roo 143 9 mediators mediator NNS cord-315656-asvf4roo 143 10 have have VBP cord-315656-asvf4roo 143 11 been be VBN cord-315656-asvf4roo 143 12 recently recently RB cord-315656-asvf4roo 143 13 extensively extensively RB cord-315656-asvf4roo 143 14 reviewed review VBN cord-315656-asvf4roo 143 15 in in IN cord-315656-asvf4roo 143 16 respective respective JJ cord-315656-asvf4roo 143 17 diseases disease NNS cord-315656-asvf4roo 143 18 including include VBG cord-315656-asvf4roo 143 19 PD PD NNP cord-315656-asvf4roo 143 20 , , , cord-315656-asvf4roo 143 21 AD ad NN cord-315656-asvf4roo 143 22 , , , cord-315656-asvf4roo 143 23 amyotrophic amyotrophic JJ cord-315656-asvf4roo 143 24 lateral lateral JJ cord-315656-asvf4roo 143 25 sclerosis sclerosis NN cord-315656-asvf4roo 143 26 ( ( -LRB- cord-315656-asvf4roo 143 27 ALS ALS NNP cord-315656-asvf4roo 143 28 ) ) -RRB- cord-315656-asvf4roo 143 29 , , , cord-315656-asvf4roo 143 30 Huntington Huntington NNP cord-315656-asvf4roo 143 31 's 's POS cord-315656-asvf4roo 143 32 disease disease NN cord-315656-asvf4roo 143 33 ( ( -LRB- cord-315656-asvf4roo 143 34 HD HD NNP cord-315656-asvf4roo 143 35 ) ) -RRB- cord-315656-asvf4roo 143 36 , , , cord-315656-asvf4roo 143 37 and and CC cord-315656-asvf4roo 143 38 multiple multiple JJ cord-315656-asvf4roo 143 39 sclerosis sclerosis NN cord-315656-asvf4roo 143 40 ( ( -LRB- cord-315656-asvf4roo 143 41 MS MS NNP cord-315656-asvf4roo 143 42 ) ) -RRB- cord-315656-asvf4roo 143 43 ( ( -LRB- cord-315656-asvf4roo 143 44 82 82 CD cord-315656-asvf4roo 143 45 - - SYM cord-315656-asvf4roo 143 46 86 86 CD cord-315656-asvf4roo 143 47 ) ) -RRB- cord-315656-asvf4roo 143 48 , , , cord-315656-asvf4roo 143 49 we -PRON- PRP cord-315656-asvf4roo 143 50 will will MD cord-315656-asvf4roo 143 51 not not RB cord-315656-asvf4roo 143 52 discuss discuss VB cord-315656-asvf4roo 143 53 in in IN cord-315656-asvf4roo 143 54 much much JJ cord-315656-asvf4roo 143 55 details detail NNS cord-315656-asvf4roo 143 56 but but CC cord-315656-asvf4roo 143 57 give give VB cord-315656-asvf4roo 143 58 some some DT cord-315656-asvf4roo 143 59 examples example NNS cord-315656-asvf4roo 143 60 . . . cord-315656-asvf4roo 144 1 For for IN cord-315656-asvf4roo 144 2 AD ad NN cord-315656-asvf4roo 144 3 , , , cord-315656-asvf4roo 144 4 pro pro JJ cord-315656-asvf4roo 144 5 - - JJ cord-315656-asvf4roo 144 6 inflammatory inflammatory JJ cord-315656-asvf4roo 144 7 factors factor NNS cord-315656-asvf4roo 144 8 are be VBP cord-315656-asvf4roo 144 9 responsible responsible JJ cord-315656-asvf4roo 144 10 for for IN cord-315656-asvf4roo 144 11 the the DT cord-315656-asvf4roo 144 12 increased increase VBN cord-315656-asvf4roo 144 13 amyloid amyloid NN cord-315656-asvf4roo 144 14 precursor precursor NN cord-315656-asvf4roo 144 15 protein protein NN cord-315656-asvf4roo 144 16 ( ( -LRB- cord-315656-asvf4roo 144 17 APP app NN cord-315656-asvf4roo 144 18 ) ) -RRB- cord-315656-asvf4roo 144 19 production production NN cord-315656-asvf4roo 144 20 and and CC cord-315656-asvf4roo 144 21 amyloid amyloid NN cord-315656-asvf4roo 144 22 - - HYPH cord-315656-asvf4roo 144 23 β β NN cord-315656-asvf4roo 144 24 ( ( -LRB- cord-315656-asvf4roo 144 25 Aβ Aβ NNP cord-315656-asvf4roo 144 26 ) ) -RRB- cord-315656-asvf4roo 144 27 load load NN cord-315656-asvf4roo 144 28 , , , cord-315656-asvf4roo 144 29 as as RB cord-315656-asvf4roo 144 30 well well RB cord-315656-asvf4roo 144 31 as as IN cord-315656-asvf4roo 144 32 tau tau NNP cord-315656-asvf4roo 144 33 hyperphosphorylation hyperphosphorylation NNP cord-315656-asvf4roo 144 34 , , , cord-315656-asvf4roo 144 35 the the DT cord-315656-asvf4roo 144 36 hallmarks hallmark NNS cord-315656-asvf4roo 144 37 of of IN cord-315656-asvf4roo 144 38 AD ad NN cord-315656-asvf4roo 144 39 . . . cord-315656-asvf4roo 145 1 Specifically specifically RB cord-315656-asvf4roo 145 2 , , , cord-315656-asvf4roo 145 3 TNF TNF NNP cord-315656-asvf4roo 145 4 - - HYPH cord-315656-asvf4roo 145 5 α α NNP cord-315656-asvf4roo 145 6 can can MD cord-315656-asvf4roo 145 7 increase increase VB cord-315656-asvf4roo 145 8 Aβ Aβ NNP cord-315656-asvf4roo 145 9 burden burden NN cord-315656-asvf4roo 145 10 by by IN cord-315656-asvf4roo 145 11 promoting promote VBG cord-315656-asvf4roo 145 12 β β NNP cord-315656-asvf4roo 145 13 - - HYPH cord-315656-asvf4roo 145 14 secretase secretase JJ cord-315656-asvf4roo 145 15 production production NN cord-315656-asvf4roo 145 16 and and CC cord-315656-asvf4roo 145 17 increased increase VBD cord-315656-asvf4roo 145 18 γ γ NN cord-315656-asvf4roo 145 19 - - HYPH cord-315656-asvf4roo 145 20 secretase secretase NNP cord-315656-asvf4roo 145 21 activity activity NN cord-315656-asvf4roo 145 22 ( ( -LRB- cord-315656-asvf4roo 145 23 87 87 CD cord-315656-asvf4roo 145 24 ) ) -RRB- cord-315656-asvf4roo 145 25 . . . cord-315656-asvf4roo 146 1 Elevated Elevated NNP cord-315656-asvf4roo 146 2 IL-6 IL-6 NNP cord-315656-asvf4roo 146 3 levels level NNS cord-315656-asvf4roo 146 4 have have VBP cord-315656-asvf4roo 146 5 been be VBN cord-315656-asvf4roo 146 6 shown show VBN cord-315656-asvf4roo 146 7 to to TO cord-315656-asvf4roo 146 8 activate activate VB cord-315656-asvf4roo 146 9 CDK5 CDK5 NNP cord-315656-asvf4roo 146 10 , , , cord-315656-asvf4roo 146 11 a a DT cord-315656-asvf4roo 146 12 kinase kinase NN cord-315656-asvf4roo 146 13 that that WDT cord-315656-asvf4roo 146 14 phosphorylate phosphorylate VBP cord-315656-asvf4roo 146 15 tau tau NN cord-315656-asvf4roo 146 16 proteins protein NNS cord-315656-asvf4roo 146 17 ( ( -LRB- cord-315656-asvf4roo 146 18 88 88 CD cord-315656-asvf4roo 146 19 ) ) -RRB- cord-315656-asvf4roo 146 20 . . . cord-315656-asvf4roo 147 1 Such such JJ cord-315656-asvf4roo 147 2 extensive extensive JJ cord-315656-asvf4roo 147 3 neuroinflammation neuroinflammation NN cord-315656-asvf4roo 147 4 thus thus RB cord-315656-asvf4roo 147 5 would would MD cord-315656-asvf4roo 147 6 cause cause VB cord-315656-asvf4roo 147 7 neuronal neuronal JJ cord-315656-asvf4roo 147 8 death death NN cord-315656-asvf4roo 147 9 that that WDT cord-315656-asvf4roo 147 10 leads lead VBZ cord-315656-asvf4roo 147 11 to to IN cord-315656-asvf4roo 147 12 cognitive cognitive JJ cord-315656-asvf4roo 147 13 impairment impairment NN cord-315656-asvf4roo 147 14 and and CC cord-315656-asvf4roo 147 15 dementia dementia NN cord-315656-asvf4roo 147 16 . . . cord-315656-asvf4roo 148 1 Alpha Alpha NNP cord-315656-asvf4roo 148 2 - - HYPH cord-315656-asvf4roo 148 3 synuclein synuclein NNP cord-315656-asvf4roo 148 4 ( ( -LRB- cord-315656-asvf4roo 148 5 α α NNP cord-315656-asvf4roo 148 6 - - HYPH cord-315656-asvf4roo 148 7 synuclein synuclein NNP cord-315656-asvf4roo 148 8 ) ) -RRB- cord-315656-asvf4roo 148 9 , , , cord-315656-asvf4roo 148 10 a a DT cord-315656-asvf4roo 148 11 major major JJ cord-315656-asvf4roo 148 12 component component NN cord-315656-asvf4roo 148 13 of of IN cord-315656-asvf4roo 148 14 Lewy Lewy NNP cord-315656-asvf4roo 148 15 bodies body NNS cord-315656-asvf4roo 148 16 in in IN cord-315656-asvf4roo 148 17 the the DT cord-315656-asvf4roo 148 18 pathogenesis pathogenesis NN cord-315656-asvf4roo 148 19 of of IN cord-315656-asvf4roo 148 20 PD PD NNP cord-315656-asvf4roo 148 21 , , , cord-315656-asvf4roo 148 22 plays play VBZ cord-315656-asvf4roo 148 23 an an DT cord-315656-asvf4roo 148 24 important important JJ cord-315656-asvf4roo 148 25 role role NN cord-315656-asvf4roo 148 26 in in IN cord-315656-asvf4roo 148 27 mediating mediate VBG cord-315656-asvf4roo 148 28 innate innate JJ cord-315656-asvf4roo 148 29 and and CC cord-315656-asvf4roo 148 30 adaptive adaptive JJ cord-315656-asvf4roo 148 31 immunity immunity NN cord-315656-asvf4roo 148 32 ( ( -LRB- cord-315656-asvf4roo 148 33 89 89 CD cord-315656-asvf4roo 148 34 ) ) -RRB- cord-315656-asvf4roo 148 35 . . . cord-315656-asvf4roo 149 1 Particularly particularly RB cord-315656-asvf4roo 149 2 , , , cord-315656-asvf4roo 149 3 the the DT cord-315656-asvf4roo 149 4 mutant mutant JJ cord-315656-asvf4roo 149 5 forms form NNS cord-315656-asvf4roo 149 6 of of IN cord-315656-asvf4roo 149 7 α α NN cord-315656-asvf4roo 149 8 - - HYPH cord-315656-asvf4roo 149 9 synuclein synuclein NNP cord-315656-asvf4roo 149 10 in in IN cord-315656-asvf4roo 149 11 PD PD NNP cord-315656-asvf4roo 149 12 could could MD cord-315656-asvf4roo 149 13 induce induce VB cord-315656-asvf4roo 149 14 microglial microglial JJ cord-315656-asvf4roo 149 15 activation activation NN cord-315656-asvf4roo 149 16 , , , cord-315656-asvf4roo 149 17 releasing release VBG cord-315656-asvf4roo 149 18 various various JJ cord-315656-asvf4roo 149 19 pro pro JJ cord-315656-asvf4roo 149 20 - - JJ cord-315656-asvf4roo 149 21 inflammatory inflammatory JJ cord-315656-asvf4roo 149 22 cytokines cytokine NNS cord-315656-asvf4roo 149 23 ( ( -LRB- cord-315656-asvf4roo 149 24 IL-6 IL-6 NNP cord-315656-asvf4roo 149 25 , , , cord-315656-asvf4roo 149 26 IL-1β IL-1β NNP cord-315656-asvf4roo 149 27 , , , cord-315656-asvf4roo 149 28 and and CC cord-315656-asvf4roo 149 29 TNF TNF NNP cord-315656-asvf4roo 149 30 - - HYPH cord-315656-asvf4roo 149 31 α α NNP cord-315656-asvf4roo 149 32 etc etc FW cord-315656-asvf4roo 149 33 . . . cord-315656-asvf4roo 149 34 ) ) -RRB- cord-315656-asvf4roo 150 1 and and CC cord-315656-asvf4roo 150 2 CXCL12 CXCL12 NNP cord-315656-asvf4roo 150 3 , , , cord-315656-asvf4roo 150 4 by by IN cord-315656-asvf4roo 150 5 recognizing recognize VBG cord-315656-asvf4roo 150 6 toll toll NN cord-315656-asvf4roo 150 7 - - HYPH cord-315656-asvf4roo 150 8 like like JJ cord-315656-asvf4roo 150 9 receptors receptor NNS cord-315656-asvf4roo 150 10 ( ( -LRB- cord-315656-asvf4roo 150 11 TLRs TLRs NNP cord-315656-asvf4roo 150 12 ) ) -RRB- cord-315656-asvf4roo 150 13 ( ( -LRB- cord-315656-asvf4roo 150 14 90 90 CD cord-315656-asvf4roo 150 15 , , , cord-315656-asvf4roo 150 16 91 91 CD cord-315656-asvf4roo 150 17 ) ) -RRB- cord-315656-asvf4roo 150 18 . . . cord-315656-asvf4roo 151 1 Similarly similarly RB cord-315656-asvf4roo 151 2 , , , cord-315656-asvf4roo 151 3 for for IN cord-315656-asvf4roo 151 4 ALS ALS NNP cord-315656-asvf4roo 151 5 , , , cord-315656-asvf4roo 151 6 the the DT cord-315656-asvf4roo 151 7 aggregated aggregate VBN cord-315656-asvf4roo 151 8 proteins protein NNS cord-315656-asvf4roo 151 9 as as IN cord-315656-asvf4roo 151 10 mutated mutated JJ cord-315656-asvf4roo 151 11 superoxide superoxide NN cord-315656-asvf4roo 151 12 dismutase dismutase NN cord-315656-asvf4roo 151 13 ( ( -LRB- cord-315656-asvf4roo 151 14 mSOD1 msod1 NN cord-315656-asvf4roo 151 15 ) ) -RRB- cord-315656-asvf4roo 151 16 , , , cord-315656-asvf4roo 151 17 caused cause VBD cord-315656-asvf4roo 151 18 motoneuron motoneuron NNP cord-315656-asvf4roo 151 19 injury injury NN cord-315656-asvf4roo 151 20 and and CC cord-315656-asvf4roo 151 21 triggered trigger VBD cord-315656-asvf4roo 151 22 microgliosis microgliosis NN cord-315656-asvf4roo 151 23 in in IN cord-315656-asvf4roo 151 24 spinal spinal JJ cord-315656-asvf4roo 151 25 cord cord NN cord-315656-asvf4roo 151 26 cultures culture NNS cord-315656-asvf4roo 151 27 by by IN cord-315656-asvf4roo 151 28 releasing release VBG cord-315656-asvf4roo 151 29 pro pro JJ cord-315656-asvf4roo 151 30 - - JJ cord-315656-asvf4roo 151 31 inflammatory inflammatory JJ cord-315656-asvf4roo 151 32 cytokines cytokine NNS cord-315656-asvf4roo 151 33 and and CC cord-315656-asvf4roo 151 34 free free JJ cord-315656-asvf4roo 151 35 radicals radical NNS cord-315656-asvf4roo 151 36 ( ( -LRB- cord-315656-asvf4roo 151 37 92 92 CD cord-315656-asvf4roo 151 38 ) ) -RRB- cord-315656-asvf4roo 151 39 . . . cord-315656-asvf4roo 152 1 Overall overall RB cord-315656-asvf4roo 152 2 , , , cord-315656-asvf4roo 152 3 the the DT cord-315656-asvf4roo 152 4 aggregated aggregate VBN cord-315656-asvf4roo 152 5 proteins protein NNS cord-315656-asvf4roo 152 6 among among IN cord-315656-asvf4roo 152 7 multiple multiple JJ cord-315656-asvf4roo 152 8 neurodegenerative neurodegenerative JJ cord-315656-asvf4roo 152 9 diseases disease NNS cord-315656-asvf4roo 152 10 including include VBG cord-315656-asvf4roo 152 11 α α NN cord-315656-asvf4roo 152 12 - - HYPH cord-315656-asvf4roo 152 13 synuclein synuclein NN cord-315656-asvf4roo 152 14 , , , cord-315656-asvf4roo 152 15 Aβ Aβ NNP cord-315656-asvf4roo 152 16 , , , cord-315656-asvf4roo 152 17 and and CC cord-315656-asvf4roo 152 18 mSOD1 msod1 NN cord-315656-asvf4roo 152 19 , , , cord-315656-asvf4roo 152 20 can can MD cord-315656-asvf4roo 152 21 initiate initiate VB cord-315656-asvf4roo 152 22 a a DT cord-315656-asvf4roo 152 23 pro pro JJ cord-315656-asvf4roo 152 24 - - JJ cord-315656-asvf4roo 152 25 inflammatory inflammatory JJ cord-315656-asvf4roo 152 26 responses response NNS cord-315656-asvf4roo 152 27 that that WDT cord-315656-asvf4roo 152 28 lead lead VBP cord-315656-asvf4roo 152 29 to to IN cord-315656-asvf4roo 152 30 a a DT cord-315656-asvf4roo 152 31 sustained sustained JJ cord-315656-asvf4roo 152 32 imbalance imbalance NN cord-315656-asvf4roo 152 33 of of IN cord-315656-asvf4roo 152 34 neuroinflammation neuroinflammation NN cord-315656-asvf4roo 152 35 and and CC cord-315656-asvf4roo 152 36 neuronal neuronal JJ cord-315656-asvf4roo 152 37 loss loss NN cord-315656-asvf4roo 152 38 due due IN cord-315656-asvf4roo 152 39 to to IN cord-315656-asvf4roo 152 40 the the DT cord-315656-asvf4roo 152 41 persistent persistent JJ cord-315656-asvf4roo 152 42 protein protein NN cord-315656-asvf4roo 152 43 aggregations aggregation NNS cord-315656-asvf4roo 152 44 ( ( -LRB- cord-315656-asvf4roo 152 45 76 76 CD cord-315656-asvf4roo 152 46 ) ) -RRB- cord-315656-asvf4roo 152 47 . . . cord-315656-asvf4roo 153 1 In in IN cord-315656-asvf4roo 153 2 addition addition NN cord-315656-asvf4roo 153 3 , , , cord-315656-asvf4roo 153 4 the the DT cord-315656-asvf4roo 153 5 nerve nerve NN cord-315656-asvf4roo 153 6 demyelination demyelination NN cord-315656-asvf4roo 153 7 was be VBD cord-315656-asvf4roo 153 8 also also RB cord-315656-asvf4roo 153 9 observed observe VBN cord-315656-asvf4roo 153 10 in in IN cord-315656-asvf4roo 153 11 both both DT cord-315656-asvf4roo 153 12 SARS SARS NNP cord-315656-asvf4roo 153 13 - - HYPH cord-315656-asvf4roo 153 14 CoV CoV NNP cord-315656-asvf4roo 153 15 and and CC cord-315656-asvf4roo 153 16 SARS SARS NNP cord-315656-asvf4roo 153 17 - - HYPH cord-315656-asvf4roo 153 18 CoV-2 CoV-2 NNP cord-315656-asvf4roo 153 19 infected infect VBN cord-315656-asvf4roo 153 20 patients patient NNS cord-315656-asvf4roo 153 21 , , , cord-315656-asvf4roo 153 22 resembling resemble VBG cord-315656-asvf4roo 153 23 the the DT cord-315656-asvf4roo 153 24 pathology pathology NN cord-315656-asvf4roo 153 25 of of IN cord-315656-asvf4roo 153 26 MS MS NNP cord-315656-asvf4roo 153 27 , , , cord-315656-asvf4roo 153 28 which which WDT cord-315656-asvf4roo 153 29 is be VBZ cord-315656-asvf4roo 153 30 also also RB cord-315656-asvf4roo 153 31 tightly tightly RB cord-315656-asvf4roo 153 32 associated associate VBN cord-315656-asvf4roo 153 33 with with IN cord-315656-asvf4roo 153 34 neuroinflammation neuroinflammation NN cord-315656-asvf4roo 153 35 ( ( -LRB- cord-315656-asvf4roo 153 36 85 85 CD cord-315656-asvf4roo 153 37 ) ) -RRB- cord-315656-asvf4roo 153 38 . . . cord-315656-asvf4roo 154 1 A a DT cord-315656-asvf4roo 154 2 similar similar JJ cord-315656-asvf4roo 154 3 pattern pattern NN cord-315656-asvf4roo 154 4 of of IN cord-315656-asvf4roo 154 5 elevated elevated JJ cord-315656-asvf4roo 154 6 proinflammatory proinflammatory JJ cord-315656-asvf4roo 154 7 factors factor NNS cord-315656-asvf4roo 154 8 ( ( -LRB- cord-315656-asvf4roo 154 9 IL-6 IL-6 NNP cord-315656-asvf4roo 154 10 , , , cord-315656-asvf4roo 154 11 IL-8 IL-8 NNP cord-315656-asvf4roo 154 12 , , , cord-315656-asvf4roo 154 13 TNF TNF NNP cord-315656-asvf4roo 154 14 etc etc NN cord-315656-asvf4roo 154 15 . . . cord-315656-asvf4roo 154 16 ) ) -RRB- cord-315656-asvf4roo 154 17 was be VBD cord-315656-asvf4roo 154 18 recorded record VBN cord-315656-asvf4roo 154 19 in in IN cord-315656-asvf4roo 154 20 the the DT cord-315656-asvf4roo 154 21 CSF CSF NNP cord-315656-asvf4roo 154 22 samples sample NNS cord-315656-asvf4roo 154 23 of of IN cord-315656-asvf4roo 154 24 MS MS NNP cord-315656-asvf4roo 154 25 patients patient NNS cord-315656-asvf4roo 154 26 with with IN cord-315656-asvf4roo 154 27 severe severe JJ cord-315656-asvf4roo 154 28 gray gray JJ cord-315656-asvf4roo 154 29 matter matter NN cord-315656-asvf4roo 154 30 damage damage NN cord-315656-asvf4roo 154 31 ( ( -LRB- cord-315656-asvf4roo 154 32 93 93 CD cord-315656-asvf4roo 154 33 ) ) -RRB- cord-315656-asvf4roo 154 34 . . . cord-315656-asvf4roo 155 1 Interestingly interestingly RB cord-315656-asvf4roo 155 2 , , , cord-315656-asvf4roo 155 3 other other JJ cord-315656-asvf4roo 155 4 neuropsychiatric neuropsychiatric JJ cord-315656-asvf4roo 155 5 diseases disease NNS cord-315656-asvf4roo 155 6 such such JJ cord-315656-asvf4roo 155 7 as as IN cord-315656-asvf4roo 155 8 schizophrenia schizophrenia NN cord-315656-asvf4roo 155 9 , , , cord-315656-asvf4roo 155 10 bipolar bipolar JJ cord-315656-asvf4roo 155 11 disorders disorder NNS cord-315656-asvf4roo 155 12 , , , cord-315656-asvf4roo 155 13 depression depression NN cord-315656-asvf4roo 155 14 , , , cord-315656-asvf4roo 155 15 and and CC cord-315656-asvf4roo 155 16 among among IN cord-315656-asvf4roo 155 17 others other NNS cord-315656-asvf4roo 155 18 , , , cord-315656-asvf4roo 155 19 are be VBP cord-315656-asvf4roo 155 20 also also RB cord-315656-asvf4roo 155 21 tightly tightly RB cord-315656-asvf4roo 155 22 linked link VBN cord-315656-asvf4roo 155 23 with with IN cord-315656-asvf4roo 155 24 the the DT cord-315656-asvf4roo 155 25 neuroinflammatory neuroinflammatory NNP cord-315656-asvf4roo 155 26 responses response NNS cord-315656-asvf4roo 155 27 ( ( -LRB- cord-315656-asvf4roo 155 28 94 94 CD cord-315656-asvf4roo 155 29 ) ) -RRB- cord-315656-asvf4roo 155 30 . . . cord-315656-asvf4roo 156 1 For for IN cord-315656-asvf4roo 156 2 instance instance NN cord-315656-asvf4roo 156 3 , , , cord-315656-asvf4roo 156 4 the the DT cord-315656-asvf4roo 156 5 levels level NNS cord-315656-asvf4roo 156 6 of of IN cord-315656-asvf4roo 156 7 pro pro JJ cord-315656-asvf4roo 156 8 - - JJ cord-315656-asvf4roo 156 9 inflammatory inflammatory JJ cord-315656-asvf4roo 156 10 mediators mediator NNS cord-315656-asvf4roo 156 11 including include VBG cord-315656-asvf4roo 156 12 IL-6 IL-6 NNP cord-315656-asvf4roo 156 13 , , , cord-315656-asvf4roo 156 14 IL-8 IL-8 NNP cord-315656-asvf4roo 156 15 , , , cord-315656-asvf4roo 156 16 IL-1β IL-1β NNP cord-315656-asvf4roo 156 17 , , , cord-315656-asvf4roo 156 18 and and CC cord-315656-asvf4roo 156 19 TNF TNF NNP cord-315656-asvf4roo 156 20 - - HYPH cord-315656-asvf4roo 156 21 α α NNP cord-315656-asvf4roo 156 22 in in IN cord-315656-asvf4roo 156 23 the the DT cord-315656-asvf4roo 156 24 CSF CSF NNP cord-315656-asvf4roo 156 25 or or CC cord-315656-asvf4roo 156 26 peripheral peripheral JJ cord-315656-asvf4roo 156 27 blood blood NN cord-315656-asvf4roo 156 28 are be VBP cord-315656-asvf4roo 156 29 obviously obviously RB cord-315656-asvf4roo 156 30 higher high JJR cord-315656-asvf4roo 156 31 in in IN cord-315656-asvf4roo 156 32 schizophrenia schizophrenia NN cord-315656-asvf4roo 156 33 patients patient NNS cord-315656-asvf4roo 156 34 ( ( -LRB- cord-315656-asvf4roo 156 35 95 95 CD cord-315656-asvf4roo 156 36 , , , cord-315656-asvf4roo 156 37 96 96 CD cord-315656-asvf4roo 156 38 ) ) -RRB- cord-315656-asvf4roo 156 39 . . . cord-315656-asvf4roo 157 1 Microglia Microglia NNP cord-315656-asvf4roo 157 2 that that WDT cord-315656-asvf4roo 157 3 release release VBP cord-315656-asvf4roo 157 4 pro pro JJ cord-315656-asvf4roo 157 5 - - JJ cord-315656-asvf4roo 157 6 inflammatory inflammatory JJ cord-315656-asvf4roo 157 7 factors factor NNS cord-315656-asvf4roo 157 8 such such JJ cord-315656-asvf4roo 157 9 as as IN cord-315656-asvf4roo 157 10 TNF TNF NNP cord-315656-asvf4roo 157 11 - - HYPH cord-315656-asvf4roo 157 12 α α NNP cord-315656-asvf4roo 157 13 can can MD cord-315656-asvf4roo 157 14 promote promote VB cord-315656-asvf4roo 157 15 the the DT cord-315656-asvf4roo 157 16 release release NN cord-315656-asvf4roo 157 17 of of IN cord-315656-asvf4roo 157 18 glutamate glutamate NN cord-315656-asvf4roo 157 19 to to TO cord-315656-asvf4roo 157 20 induce induce VB cord-315656-asvf4roo 157 21 oligodendrocyte oligodendrocyte NNP cord-315656-asvf4roo 157 22 dysfunction dysfunction NN cord-315656-asvf4roo 157 23 , , , cord-315656-asvf4roo 157 24 resulting result VBG cord-315656-asvf4roo 157 25 in in IN cord-315656-asvf4roo 157 26 abnormal abnormal JJ cord-315656-asvf4roo 157 27 neural neural JJ cord-315656-asvf4roo 157 28 networks network NNS cord-315656-asvf4roo 157 29 in in IN cord-315656-asvf4roo 157 30 the the DT cord-315656-asvf4roo 157 31 brain brain NN cord-315656-asvf4roo 157 32 of of IN cord-315656-asvf4roo 157 33 schizophrenic schizophrenic JJ cord-315656-asvf4roo 157 34 patients patient NNS cord-315656-asvf4roo 157 35 ( ( -LRB- cord-315656-asvf4roo 157 36 97 97 CD cord-315656-asvf4roo 157 37 ) ) -RRB- cord-315656-asvf4roo 157 38 . . . cord-315656-asvf4roo 158 1 Notably notably RB cord-315656-asvf4roo 158 2 , , , cord-315656-asvf4roo 158 3 the the DT cord-315656-asvf4roo 158 4 altered altered JJ cord-315656-asvf4roo 158 5 mental mental JJ cord-315656-asvf4roo 158 6 status status NN cord-315656-asvf4roo 158 7 and and CC cord-315656-asvf4roo 158 8 neuropsychiatric neuropsychiatric JJ cord-315656-asvf4roo 158 9 presentations presentation NNS cord-315656-asvf4roo 158 10 were be VBD cord-315656-asvf4roo 158 11 recorded record VBN cord-315656-asvf4roo 158 12 in in IN cord-315656-asvf4roo 158 13 COVID-19 COVID-19 NNP cord-315656-asvf4roo 158 14 patients patient NNS cord-315656-asvf4roo 158 15 and and CC cord-315656-asvf4roo 158 16 other other JJ cord-315656-asvf4roo 158 17 coronavirus coronavirus NN cord-315656-asvf4roo 158 18 infected infect VBN cord-315656-asvf4roo 158 19 diseases disease NNS cord-315656-asvf4roo 158 20 ( ( -LRB- cord-315656-asvf4roo 158 21 98 98 CD cord-315656-asvf4roo 158 22 , , , cord-315656-asvf4roo 158 23 99 99 CD cord-315656-asvf4roo 158 24 ) ) -RRB- cord-315656-asvf4roo 158 25 . . . cord-315656-asvf4roo 159 1 Above above IN cord-315656-asvf4roo 159 2 all all DT cord-315656-asvf4roo 159 3 , , , cord-315656-asvf4roo 159 4 the the DT cord-315656-asvf4roo 159 5 neuroinflammation neuroinflammation NN cord-315656-asvf4roo 159 6 imbalance imbalance NN cord-315656-asvf4roo 159 7 toward toward IN cord-315656-asvf4roo 159 8 proinflammatory proinflammatory JJ cord-315656-asvf4roo 159 9 states state NNS cord-315656-asvf4roo 159 10 shows show VBZ cord-315656-asvf4roo 159 11 to to TO cord-315656-asvf4roo 159 12 be be VB cord-315656-asvf4roo 159 13 a a DT cord-315656-asvf4roo 159 14 shared share VBN cord-315656-asvf4roo 159 15 hallmark hallmark NN cord-315656-asvf4roo 159 16 of of IN cord-315656-asvf4roo 159 17 various various JJ cord-315656-asvf4roo 159 18 neurological neurological JJ cord-315656-asvf4roo 159 19 diseases disease NNS cord-315656-asvf4roo 159 20 , , , cord-315656-asvf4roo 159 21 hence hence RB cord-315656-asvf4roo 159 22 , , , cord-315656-asvf4roo 159 23 the the DT cord-315656-asvf4roo 159 24 CNS CNS NNP cord-315656-asvf4roo 159 25 infiltrated infiltrate VBD cord-315656-asvf4roo 159 26 immune immune JJ cord-315656-asvf4roo 159 27 mediators mediator NNS cord-315656-asvf4roo 159 28 in in IN cord-315656-asvf4roo 160 1 COVID-19 covid-19 JJ cord-315656-asvf4roo 160 2 patients patient NNS cord-315656-asvf4roo 160 3 would would MD cord-315656-asvf4roo 160 4 probably probably RB cord-315656-asvf4roo 160 5 take take VB cord-315656-asvf4roo 160 6 part part NN cord-315656-asvf4roo 160 7 in in IN cord-315656-asvf4roo 160 8 the the DT cord-315656-asvf4roo 160 9 chronic chronic JJ cord-315656-asvf4roo 160 10 pathogenesis pathogenesis NN cord-315656-asvf4roo 160 11 process process NN cord-315656-asvf4roo 160 12 and and CC cord-315656-asvf4roo 160 13 bring bring VB cord-315656-asvf4roo 160 14 about about RP cord-315656-asvf4roo 160 15 certain certain JJ cord-315656-asvf4roo 160 16 irreversible irreversible JJ cord-315656-asvf4roo 160 17 neuronal neuronal JJ cord-315656-asvf4roo 160 18 impairments impairment NNS cord-315656-asvf4roo 160 19 . . . cord-315656-asvf4roo 161 1 In in IN cord-315656-asvf4roo 161 2 another another DT cord-315656-asvf4roo 161 3 hand hand NN cord-315656-asvf4roo 161 4 , , , cord-315656-asvf4roo 161 5 given give VBN cord-315656-asvf4roo 161 6 that that IN cord-315656-asvf4roo 161 7 SARS SARS NNP cord-315656-asvf4roo 161 8 - - HYPH cord-315656-asvf4roo 161 9 CoV-2 CoV-2 NNP cord-315656-asvf4roo 161 10 viruses virus NNS cord-315656-asvf4roo 161 11 have have VBP cord-315656-asvf4roo 161 12 invaded invade VBN cord-315656-asvf4roo 161 13 the the DT cord-315656-asvf4roo 161 14 CNS CNS NNP cord-315656-asvf4roo 161 15 and and CC cord-315656-asvf4roo 161 16 can can MD cord-315656-asvf4roo 161 17 be be VB cord-315656-asvf4roo 161 18 detected detect VBN cord-315656-asvf4roo 161 19 in in IN cord-315656-asvf4roo 161 20 the the DT cord-315656-asvf4roo 161 21 CSF CSF NNP cord-315656-asvf4roo 161 22 , , , cord-315656-asvf4roo 161 23 their -PRON- PRP$ cord-315656-asvf4roo 161 24 direct direct JJ cord-315656-asvf4roo 161 25 effects effect NNS cord-315656-asvf4roo 161 26 in in IN cord-315656-asvf4roo 161 27 the the DT cord-315656-asvf4roo 161 28 chronic chronic JJ cord-315656-asvf4roo 161 29 modifications modification NNS cord-315656-asvf4roo 161 30 of of IN cord-315656-asvf4roo 161 31 neural neural JJ cord-315656-asvf4roo 161 32 circuits circuit NNS cord-315656-asvf4roo 161 33 worth worth JJ cord-315656-asvf4roo 161 34 further further JJ cord-315656-asvf4roo 161 35 investigations investigation NNS cord-315656-asvf4roo 161 36 . . . cord-315656-asvf4roo 162 1 Also also RB cord-315656-asvf4roo 162 2 , , , cord-315656-asvf4roo 162 3 it -PRON- PRP cord-315656-asvf4roo 162 4 is be VBZ cord-315656-asvf4roo 162 5 intriguing intriguing JJ cord-315656-asvf4roo 162 6 to to TO cord-315656-asvf4roo 162 7 address address VB cord-315656-asvf4roo 162 8 whether whether IN cord-315656-asvf4roo 162 9 the the DT cord-315656-asvf4roo 162 10 infection infection NN cord-315656-asvf4roo 162 11 increases increase VBZ cord-315656-asvf4roo 162 12 the the DT cord-315656-asvf4roo 162 13 risk risk NN cord-315656-asvf4roo 162 14 of of IN cord-315656-asvf4roo 162 15 developing develop VBG cord-315656-asvf4roo 162 16 chronic chronic JJ cord-315656-asvf4roo 162 17 neurodegenerative neurodegenerative JJ cord-315656-asvf4roo 162 18 diseases disease NNS cord-315656-asvf4roo 162 19 . . . cord-315656-asvf4roo 163 1 The the DT cord-315656-asvf4roo 163 2 Braak Braak NNP cord-315656-asvf4roo 163 3 hypothesis hypothesis NN cord-315656-asvf4roo 163 4 regarding regard VBG cord-315656-asvf4roo 163 5 the the DT cord-315656-asvf4roo 163 6 etiology etiology NN cord-315656-asvf4roo 163 7 of of IN cord-315656-asvf4roo 163 8 sporadic sporadic JJ cord-315656-asvf4roo 163 9 PD PD NNP cord-315656-asvf4roo 163 10 proposes propose VBZ cord-315656-asvf4roo 163 11 that that IN cord-315656-asvf4roo 163 12 neurotropic neurotropic NNP cord-315656-asvf4roo 163 13 viruses virus NNS cord-315656-asvf4roo 163 14 entering enter VBG cord-315656-asvf4roo 163 15 the the DT cord-315656-asvf4roo 163 16 nasal nasal NN cord-315656-asvf4roo 163 17 cavity cavity NN cord-315656-asvf4roo 163 18 and and CC cord-315656-asvf4roo 163 19 gastrointestinal gastrointestinal JJ cord-315656-asvf4roo 163 20 tract tract NN cord-315656-asvf4roo 163 21 may may MD cord-315656-asvf4roo 163 22 trigger trigger VB cord-315656-asvf4roo 163 23 Lewy Lewy NNP cord-315656-asvf4roo 163 24 pathology pathology NN cord-315656-asvf4roo 163 25 , , , cord-315656-asvf4roo 163 26 which which WDT cord-315656-asvf4roo 163 27 then then RB cord-315656-asvf4roo 163 28 spreads spread VBZ cord-315656-asvf4roo 163 29 to to IN cord-315656-asvf4roo 163 30 the the DT cord-315656-asvf4roo 163 31 CNS CNS NNP cord-315656-asvf4roo 163 32 through through IN cord-315656-asvf4roo 163 33 transneuronal transneuronal JJ cord-315656-asvf4roo 163 34 transport transport NN cord-315656-asvf4roo 163 35 , , , cord-315656-asvf4roo 163 36 resulting result VBG cord-315656-asvf4roo 163 37 in in IN cord-315656-asvf4roo 163 38 neurodegeneration neurodegeneration NN cord-315656-asvf4roo 163 39 in in IN cord-315656-asvf4roo 163 40 critical critical JJ cord-315656-asvf4roo 163 41 brain brain NN cord-315656-asvf4roo 163 42 nuclei nucleus NNS cord-315656-asvf4roo 163 43 ( ( -LRB- cord-315656-asvf4roo 163 44 100 100 CD cord-315656-asvf4roo 163 45 ) ) -RRB- cord-315656-asvf4roo 163 46 . . . cord-315656-asvf4roo 164 1 Recent recent JJ cord-315656-asvf4roo 164 2 studies study NNS cord-315656-asvf4roo 164 3 have have VBP cord-315656-asvf4roo 164 4 confirmed confirm VBN cord-315656-asvf4roo 164 5 the the DT cord-315656-asvf4roo 164 6 nasal nasal NN cord-315656-asvf4roo 164 7 - - HYPH cord-315656-asvf4roo 164 8 brain brain NN cord-315656-asvf4roo 164 9 and and CC cord-315656-asvf4roo 164 10 gut gut NN cord-315656-asvf4roo 164 11 - - HYPH cord-315656-asvf4roo 164 12 brain brain NN cord-315656-asvf4roo 164 13 deliveries delivery NNS cord-315656-asvf4roo 164 14 in in IN cord-315656-asvf4roo 164 15 the the DT cord-315656-asvf4roo 164 16 pathogenesis pathogenesis NN cord-315656-asvf4roo 164 17 of of IN cord-315656-asvf4roo 164 18 PD PD NNP cord-315656-asvf4roo 164 19 ( ( -LRB- cord-315656-asvf4roo 164 20 101 101 CD cord-315656-asvf4roo 164 21 , , , cord-315656-asvf4roo 164 22 102 102 CD cord-315656-asvf4roo 164 23 ) ) -RRB- cord-315656-asvf4roo 164 24 . . . cord-315656-asvf4roo 165 1 Interestingly interestingly RB cord-315656-asvf4roo 165 2 , , , cord-315656-asvf4roo 165 3 the the DT cord-315656-asvf4roo 165 4 symptoms symptom NNS cord-315656-asvf4roo 165 5 of of IN cord-315656-asvf4roo 165 6 anosmia anosmia NN cord-315656-asvf4roo 165 7 and and CC cord-315656-asvf4roo 165 8 diarrhea diarrhea NN cord-315656-asvf4roo 165 9 of of IN cord-315656-asvf4roo 165 10 COVID-19 covid-19 JJ cord-315656-asvf4roo 165 11 patients patient NNS cord-315656-asvf4roo 165 12 indicate indicate VBP cord-315656-asvf4roo 165 13 the the DT cord-315656-asvf4roo 165 14 nasal nasal NN cord-315656-asvf4roo 165 15 and and CC cord-315656-asvf4roo 165 16 digestive digestive JJ cord-315656-asvf4roo 165 17 system system NN cord-315656-asvf4roo 165 18 as as IN cord-315656-asvf4roo 165 19 the the DT cord-315656-asvf4roo 165 20 routes route NNS cord-315656-asvf4roo 165 21 of of IN cord-315656-asvf4roo 165 22 viral viral JJ cord-315656-asvf4roo 165 23 infection infection NN cord-315656-asvf4roo 165 24 , , , cord-315656-asvf4roo 165 25 which which WDT cord-315656-asvf4roo 165 26 may may MD cord-315656-asvf4roo 165 27 echo echo VB cord-315656-asvf4roo 165 28 the the DT cord-315656-asvf4roo 165 29 Braak Braak NNP cord-315656-asvf4roo 165 30 staging stage VBG cord-315656-asvf4roo 165 31 evidence evidence NN cord-315656-asvf4roo 165 32 that that IN cord-315656-asvf4roo 165 33 the the DT cord-315656-asvf4roo 165 34 prodromal prodromal JJ cord-315656-asvf4roo 165 35 or or CC cord-315656-asvf4roo 165 36 preclinical preclinical JJ cord-315656-asvf4roo 165 37 stage stage NN cord-315656-asvf4roo 165 38 of of IN cord-315656-asvf4roo 165 39 PD PD NNP cord-315656-asvf4roo 165 40 is be VBZ cord-315656-asvf4roo 165 41 characterized characterize VBN cord-315656-asvf4roo 165 42 by by IN cord-315656-asvf4roo 165 43 olfactory olfactory JJ cord-315656-asvf4roo 165 44 and and CC cord-315656-asvf4roo 165 45 gastrointestinal gastrointestinal JJ cord-315656-asvf4roo 165 46 symptoms symptom NNS cord-315656-asvf4roo 165 47 ( ( -LRB- cord-315656-asvf4roo 165 48 103 103 CD cord-315656-asvf4roo 165 49 ) ) -RRB- cord-315656-asvf4roo 165 50 . . . cord-315656-asvf4roo 166 1 Even even RB cord-315656-asvf4roo 166 2 though though IN cord-315656-asvf4roo 166 3 COVID-19 covid-19 JJ cord-315656-asvf4roo 166 4 respiratory respiratory JJ cord-315656-asvf4roo 166 5 tract tract NN cord-315656-asvf4roo 166 6 infections infection NNS cord-315656-asvf4roo 166 7 and and CC cord-315656-asvf4roo 166 8 cardiovascular cardiovascular JJ cord-315656-asvf4roo 166 9 events event NNS cord-315656-asvf4roo 166 10 are be VBP cord-315656-asvf4roo 166 11 the the DT cord-315656-asvf4roo 166 12 main main JJ cord-315656-asvf4roo 166 13 causes cause NNS cord-315656-asvf4roo 166 14 of of IN cord-315656-asvf4roo 166 15 death death NN cord-315656-asvf4roo 166 16 , , , cord-315656-asvf4roo 166 17 the the DT cord-315656-asvf4roo 166 18 clinical clinical JJ cord-315656-asvf4roo 166 19 awareness awareness NN cord-315656-asvf4roo 166 20 of of IN cord-315656-asvf4roo 166 21 neurological neurological JJ cord-315656-asvf4roo 166 22 impairments impairment NNS cord-315656-asvf4roo 166 23 can can MD cord-315656-asvf4roo 166 24 reduce reduce VB cord-315656-asvf4roo 166 25 the the DT cord-315656-asvf4roo 166 26 mortality mortality NN cord-315656-asvf4roo 166 27 of of IN cord-315656-asvf4roo 166 28 infected infected JJ cord-315656-asvf4roo 166 29 patients patient NNS cord-315656-asvf4roo 166 30 . . . cord-315656-asvf4roo 167 1 To to TO cord-315656-asvf4roo 167 2 reduce reduce VB cord-315656-asvf4roo 167 3 the the DT cord-315656-asvf4roo 167 4 risk risk NN cord-315656-asvf4roo 167 5 of of IN cord-315656-asvf4roo 167 6 those those DT cord-315656-asvf4roo 167 7 neurological neurological JJ cord-315656-asvf4roo 167 8 complications complication NNS cord-315656-asvf4roo 167 9 , , , cord-315656-asvf4roo 167 10 further further JJ cord-315656-asvf4roo 167 11 investigations investigation NNS cord-315656-asvf4roo 167 12 are be VBP cord-315656-asvf4roo 167 13 needed need VBN cord-315656-asvf4roo 167 14 to to TO cord-315656-asvf4roo 167 15 determine determine VB cord-315656-asvf4roo 167 16 specific specific JJ cord-315656-asvf4roo 167 17 risk risk NN cord-315656-asvf4roo 167 18 factors factor NNS cord-315656-asvf4roo 167 19 or or CC cord-315656-asvf4roo 167 20 protective protective JJ cord-315656-asvf4roo 167 21 determinants determinant NNS cord-315656-asvf4roo 167 22 of of IN cord-315656-asvf4roo 167 23 neurological neurological JJ cord-315656-asvf4roo 167 24 events event NNS cord-315656-asvf4roo 167 25 . . . cord-315656-asvf4roo 168 1 Although although IN cord-315656-asvf4roo 168 2 recovery recovery NN cord-315656-asvf4roo 168 3 from from IN cord-315656-asvf4roo 168 4 the the DT cord-315656-asvf4roo 168 5 acute acute JJ cord-315656-asvf4roo 168 6 phase phase NN cord-315656-asvf4roo 168 7 of of IN cord-315656-asvf4roo 168 8 infection infection NN cord-315656-asvf4roo 168 9 can can MD cord-315656-asvf4roo 168 10 of of IN cord-315656-asvf4roo 168 11 course course NN cord-315656-asvf4roo 168 12 be be VB cord-315656-asvf4roo 168 13 relieved relieve VBN cord-315656-asvf4roo 168 14 from from IN cord-315656-asvf4roo 168 15 a a DT cord-315656-asvf4roo 168 16 public public JJ cord-315656-asvf4roo 168 17 health health NN cord-315656-asvf4roo 168 18 perspective perspective NN cord-315656-asvf4roo 168 19 and and CC cord-315656-asvf4roo 168 20 help help VB cord-315656-asvf4roo 168 21 stop stop VB cord-315656-asvf4roo 168 22 the the DT cord-315656-asvf4roo 168 23 spread spread NN cord-315656-asvf4roo 168 24 of of IN cord-315656-asvf4roo 168 25 infection infection NN cord-315656-asvf4roo 168 26 , , , cord-315656-asvf4roo 168 27 the the DT cord-315656-asvf4roo 168 28 long long JJ cord-315656-asvf4roo 168 29 - - HYPH cord-315656-asvf4roo 168 30 term term NN cord-315656-asvf4roo 168 31 neurological neurological JJ cord-315656-asvf4roo 168 32 effects effect NNS cord-315656-asvf4roo 168 33 of of IN cord-315656-asvf4roo 168 34 the the DT cord-315656-asvf4roo 168 35 disease disease NN cord-315656-asvf4roo 168 36 must must MD cord-315656-asvf4roo 168 37 also also RB cord-315656-asvf4roo 168 38 be be VB cord-315656-asvf4roo 168 39 considered consider VBN cord-315656-asvf4roo 168 40 . . . cord-315656-asvf4roo 169 1 So so RB cord-315656-asvf4roo 169 2 far far RB cord-315656-asvf4roo 169 3 , , , cord-315656-asvf4roo 169 4 mounting mount VBG cord-315656-asvf4roo 169 5 studies study NNS cord-315656-asvf4roo 169 6 have have VBP cord-315656-asvf4roo 169 7 reported report VBN cord-315656-asvf4roo 169 8 various various JJ cord-315656-asvf4roo 169 9 neurological neurological JJ cord-315656-asvf4roo 169 10 manifestations manifestation NNS cord-315656-asvf4roo 169 11 , , , cord-315656-asvf4roo 169 12 however however RB cord-315656-asvf4roo 169 13 , , , cord-315656-asvf4roo 169 14 the the DT cord-315656-asvf4roo 169 15 neurotropic neurotropic NNP cord-315656-asvf4roo 169 16 potential potential NN cord-315656-asvf4roo 169 17 and and CC cord-315656-asvf4roo 169 18 chronic chronic JJ cord-315656-asvf4roo 169 19 neurological neurological JJ cord-315656-asvf4roo 169 20 effects effect NNS cord-315656-asvf4roo 169 21 of of IN cord-315656-asvf4roo 169 22 the the DT cord-315656-asvf4roo 169 23 SARS SARS NNP cord-315656-asvf4roo 169 24 - - HYPH cord-315656-asvf4roo 169 25 CoV-2 CoV-2 NNP cord-315656-asvf4roo 169 26 virus virus NN cord-315656-asvf4roo 169 27 remains remain VBZ cord-315656-asvf4roo 169 28 to to TO cord-315656-asvf4roo 169 29 be be VB cord-315656-asvf4roo 169 30 fully fully RB cord-315656-asvf4roo 169 31 addressed address VBN cord-315656-asvf4roo 169 32 . . . cord-315656-asvf4roo 170 1 Currently currently RB cord-315656-asvf4roo 170 2 , , , cord-315656-asvf4roo 170 3 the the DT cord-315656-asvf4roo 170 4 urgent urgent JJ cord-315656-asvf4roo 170 5 need need NN cord-315656-asvf4roo 170 6 for for IN cord-315656-asvf4roo 170 7 treating treat VBG cord-315656-asvf4roo 170 8 COVID-19 covid-19 JJ cord-315656-asvf4roo 170 9 severe severe JJ cord-315656-asvf4roo 170 10 patients patient NNS cord-315656-asvf4roo 170 11 is be VBZ cord-315656-asvf4roo 170 12 still still RB cord-315656-asvf4roo 170 13 suppressing suppress VBG cord-315656-asvf4roo 170 14 cytokine cytokine JJ cord-315656-asvf4roo 170 15 storms storm NNS cord-315656-asvf4roo 170 16 and and CC cord-315656-asvf4roo 170 17 balancing balance VBG cord-315656-asvf4roo 170 18 the the DT cord-315656-asvf4roo 170 19 immune immune JJ cord-315656-asvf4roo 170 20 system system NN cord-315656-asvf4roo 170 21 , , , cord-315656-asvf4roo 170 22 particularly particularly RB cord-315656-asvf4roo 170 23 also also RB cord-315656-asvf4roo 170 24 in in IN cord-315656-asvf4roo 170 25 the the DT cord-315656-asvf4roo 170 26 CNS CNS NNP cord-315656-asvf4roo 170 27 . . . cord-315656-asvf4roo 171 1 Unfortunately unfortunately RB cord-315656-asvf4roo 171 2 , , , cord-315656-asvf4roo 171 3 no no DT cord-315656-asvf4roo 171 4 specific specific JJ cord-315656-asvf4roo 171 5 medicine medicine NN cord-315656-asvf4roo 171 6 against against IN cord-315656-asvf4roo 171 7 COVID-19 COVID-19 NNP cord-315656-asvf4roo 171 8 has have VBZ cord-315656-asvf4roo 171 9 been be VBN cord-315656-asvf4roo 171 10 developed develop VBN cord-315656-asvf4roo 171 11 till till IN cord-315656-asvf4roo 171 12 now now RB cord-315656-asvf4roo 171 13 . . . cord-315656-asvf4roo 172 1 Apart apart RB cord-315656-asvf4roo 172 2 from from IN cord-315656-asvf4roo 172 3 using use VBG cord-315656-asvf4roo 172 4 mAbs mabs NN cord-315656-asvf4roo 172 5 such such JJ cord-315656-asvf4roo 172 6 as as IN cord-315656-asvf4roo 172 7 Tocilizumab Tocilizumab NNP cord-315656-asvf4roo 172 8 , , , cord-315656-asvf4roo 172 9 Satralizumab Satralizumab NNP cord-315656-asvf4roo 172 10 , , , cord-315656-asvf4roo 172 11 and and CC cord-315656-asvf4roo 172 12 Sarilumab Sarilumab NNP cord-315656-asvf4roo 172 13 , , , cord-315656-asvf4roo 172 14 a a DT cord-315656-asvf4roo 172 15 recent recent JJ cord-315656-asvf4roo 172 16 study study NN cord-315656-asvf4roo 172 17 reported report VBD cord-315656-asvf4roo 172 18 that that IN cord-315656-asvf4roo 172 19 dexamethasone dexamethasone NN cord-315656-asvf4roo 172 20 , , , cord-315656-asvf4roo 172 21 a a DT cord-315656-asvf4roo 172 22 corticosteroid corticosteroid NN cord-315656-asvf4roo 172 23 used use VBN cord-315656-asvf4roo 172 24 widely widely RB cord-315656-asvf4roo 172 25 for for IN cord-315656-asvf4roo 172 26 its -PRON- PRP$ cord-315656-asvf4roo 172 27 anti anti JJ cord-315656-asvf4roo 172 28 - - JJ cord-315656-asvf4roo 172 29 inflammatory inflammatory JJ cord-315656-asvf4roo 172 30 and and CC cord-315656-asvf4roo 172 31 immunosuppressant immunosuppressant JJ cord-315656-asvf4roo 172 32 effects effect NNS cord-315656-asvf4roo 172 33 , , , cord-315656-asvf4roo 172 34 showed show VBD cord-315656-asvf4roo 172 35 to to TO cord-315656-asvf4roo 172 36 reduce reduce VB cord-315656-asvf4roo 172 37 the the DT cord-315656-asvf4roo 172 38 mortality mortality NN cord-315656-asvf4roo 172 39 by by IN cord-315656-asvf4roo 172 40 1/3 1/3 CD cord-315656-asvf4roo 172 41 among among IN cord-315656-asvf4roo 172 42 patients patient NNS cord-315656-asvf4roo 172 43 receiving receive VBG cord-315656-asvf4roo 172 44 invasive invasive JJ cord-315656-asvf4roo 172 45 mechanical mechanical JJ cord-315656-asvf4roo 172 46 ventilation ventilation NN cord-315656-asvf4roo 172 47 and and CC cord-315656-asvf4roo 172 48 by by IN cord-315656-asvf4roo 172 49 1/5 1/5 CD cord-315656-asvf4roo 172 50 among among IN cord-315656-asvf4roo 172 51 patients patient NNS cord-315656-asvf4roo 172 52 receiving receive VBG cord-315656-asvf4roo 172 53 oxygen oxygen NN cord-315656-asvf4roo 172 54 by by IN cord-315656-asvf4roo 172 55 other other JJ cord-315656-asvf4roo 172 56 means mean NNS cord-315656-asvf4roo 172 57 , , , cord-315656-asvf4roo 172 58 but but CC cord-315656-asvf4roo 172 59 had have VBD cord-315656-asvf4roo 172 60 no no DT cord-315656-asvf4roo 172 61 effects effect NNS cord-315656-asvf4roo 172 62 for for IN cord-315656-asvf4roo 172 63 patients patient NNS cord-315656-asvf4roo 172 64 without without IN cord-315656-asvf4roo 172 65 receiving receive VBG cord-315656-asvf4roo 172 66 respiratory respiratory JJ cord-315656-asvf4roo 172 67 support support NN cord-315656-asvf4roo 172 68 ( ( -LRB- cord-315656-asvf4roo 172 69 104 104 CD cord-315656-asvf4roo 172 70 ) ) -RRB- cord-315656-asvf4roo 172 71 . . . cord-315656-asvf4roo 173 1 However however RB cord-315656-asvf4roo 173 2 , , , cord-315656-asvf4roo 173 3 this this DT cord-315656-asvf4roo 173 4 drug drug NN cord-315656-asvf4roo 173 5 , , , cord-315656-asvf4roo 173 6 as as IN cord-315656-asvf4roo 173 7 mentioned mention VBN cord-315656-asvf4roo 173 8 earlier early RBR cord-315656-asvf4roo 173 9 as as IN cord-315656-asvf4roo 173 10 other other JJ cord-315656-asvf4roo 173 11 corticosteroid corticosteroid NN cord-315656-asvf4roo 173 12 drugs drug NNS cord-315656-asvf4roo 173 13 , , , cord-315656-asvf4roo 173 14 was be VBD cord-315656-asvf4roo 173 15 also also RB cord-315656-asvf4roo 173 16 under under IN cord-315656-asvf4roo 173 17 critical critical JJ cord-315656-asvf4roo 173 18 concerns concern NNS cord-315656-asvf4roo 173 19 of of IN cord-315656-asvf4roo 173 20 side side NN cord-315656-asvf4roo 173 21 effects effect NNS cord-315656-asvf4roo 173 22 . . . cord-315656-asvf4roo 174 1 Different different JJ cord-315656-asvf4roo 174 2 drugs drug NNS cord-315656-asvf4roo 174 3 work work VBP cord-315656-asvf4roo 174 4 depending depend VBG cord-315656-asvf4roo 174 5 on on IN cord-315656-asvf4roo 174 6 the the DT cord-315656-asvf4roo 174 7 severity severity NN cord-315656-asvf4roo 174 8 of of IN cord-315656-asvf4roo 174 9 disease disease NN cord-315656-asvf4roo 174 10 and and CC cord-315656-asvf4roo 174 11 the the DT cord-315656-asvf4roo 174 12 timepoint timepoint NN cord-315656-asvf4roo 174 13 for for IN cord-315656-asvf4roo 174 14 delivery delivery NN cord-315656-asvf4roo 174 15 . . . cord-315656-asvf4roo 175 1 Adding add VBG cord-315656-asvf4roo 175 2 the the DT cord-315656-asvf4roo 175 3 need need NN cord-315656-asvf4roo 175 4 of of IN cord-315656-asvf4roo 175 5 treating treat VBG cord-315656-asvf4roo 175 6 neurological neurological JJ cord-315656-asvf4roo 175 7 complications complication NNS cord-315656-asvf4roo 175 8 , , , cord-315656-asvf4roo 175 9 the the DT cord-315656-asvf4roo 175 10 therapeutic therapeutic JJ cord-315656-asvf4roo 175 11 strategy strategy NN cord-315656-asvf4roo 175 12 becomes become VBZ cord-315656-asvf4roo 175 13 more more RBR cord-315656-asvf4roo 175 14 complicated complicated JJ cord-315656-asvf4roo 175 15 . . . cord-315656-asvf4roo 176 1 It -PRON- PRP cord-315656-asvf4roo 176 2 is be VBZ cord-315656-asvf4roo 176 3 possible possible JJ cord-315656-asvf4roo 176 4 that that IN cord-315656-asvf4roo 176 5 the the DT cord-315656-asvf4roo 176 6 anti anti JJ cord-315656-asvf4roo 176 7 - - JJ cord-315656-asvf4roo 176 8 neuroinflammatory neuroinflammatory JJ cord-315656-asvf4roo 176 9 drugs drug NNS cord-315656-asvf4roo 176 10 that that WDT cord-315656-asvf4roo 176 11 used use VBD cord-315656-asvf4roo 176 12 for for IN cord-315656-asvf4roo 176 13 treating treat VBG cord-315656-asvf4roo 176 14 neurodegenerative neurodegenerative JJ cord-315656-asvf4roo 176 15 diseases disease NNS cord-315656-asvf4roo 176 16 might may MD cord-315656-asvf4roo 176 17 be be VB cord-315656-asvf4roo 176 18 repurposed repurpose VBN cord-315656-asvf4roo 176 19 , , , cord-315656-asvf4roo 176 20 due due IN cord-315656-asvf4roo 176 21 to to IN cord-315656-asvf4roo 176 22 their -PRON- PRP$ cord-315656-asvf4roo 176 23 capability capability NN cord-315656-asvf4roo 176 24 of of IN cord-315656-asvf4roo 176 25 crossing cross VBG cord-315656-asvf4roo 176 26 the the DT cord-315656-asvf4roo 176 27 BBB BBB NNP cord-315656-asvf4roo 176 28 . . . cord-315656-asvf4roo 177 1 However however RB cord-315656-asvf4roo 177 2 , , , cord-315656-asvf4roo 177 3 the the DT cord-315656-asvf4roo 177 4 candidate candidate NN cord-315656-asvf4roo 177 5 drugs drug NNS cord-315656-asvf4roo 177 6 and and CC cord-315656-asvf4roo 177 7 doses dose NNS cord-315656-asvf4roo 177 8 would would MD cord-315656-asvf4roo 177 9 be be VB cord-315656-asvf4roo 177 10 really really RB cord-315656-asvf4roo 177 11 dependent dependent JJ cord-315656-asvf4roo 177 12 on on IN cord-315656-asvf4roo 177 13 each each DT cord-315656-asvf4roo 177 14 individual individual NN cord-315656-asvf4roo 177 15 , , , cord-315656-asvf4roo 177 16 since since IN cord-315656-asvf4roo 177 17 neurological neurological JJ cord-315656-asvf4roo 177 18 complications complication NNS cord-315656-asvf4roo 177 19 were be VBD cord-315656-asvf4roo 177 20 heterogenous heterogenous JJ cord-315656-asvf4roo 177 21 among among IN cord-315656-asvf4roo 177 22 populations population NNS cord-315656-asvf4roo 177 23 , , , cord-315656-asvf4roo 177 24 and and CC cord-315656-asvf4roo 177 25 importantly importantly RB cord-315656-asvf4roo 177 26 , , , cord-315656-asvf4roo 177 27 their -PRON- PRP$ cord-315656-asvf4roo 177 28 safety safety NN cord-315656-asvf4roo 177 29 for for IN cord-315656-asvf4roo 177 30 normal normal JJ cord-315656-asvf4roo 177 31 people people NNS cord-315656-asvf4roo 177 32 infected infect VBN cord-315656-asvf4roo 177 33 with with IN cord-315656-asvf4roo 177 34 SARS SARS NNP cord-315656-asvf4roo 177 35 - - HYPH cord-315656-asvf4roo 177 36 CoV-2 CoV-2 NNP cord-315656-asvf4roo 177 37 will will MD cord-315656-asvf4roo 177 38 also also RB cord-315656-asvf4roo 177 39 await await VB cord-315656-asvf4roo 177 40 clinical clinical JJ cord-315656-asvf4roo 177 41 trials trial NNS cord-315656-asvf4roo 177 42 to to TO cord-315656-asvf4roo 177 43 be be VB cord-315656-asvf4roo 177 44 proven prove VBN cord-315656-asvf4roo 177 45 . . . cord-315656-asvf4roo 178 1 Additionally additionally RB cord-315656-asvf4roo 178 2 , , , cord-315656-asvf4roo 178 3 another another DT cord-315656-asvf4roo 178 4 method method NN cord-315656-asvf4roo 178 5 to to TO cord-315656-asvf4roo 178 6 alleviate alleviate VB cord-315656-asvf4roo 178 7 the the DT cord-315656-asvf4roo 178 8 fierce fierce JJ cord-315656-asvf4roo 178 9 immune immune JJ cord-315656-asvf4roo 178 10 responses response NNS cord-315656-asvf4roo 178 11 is be VBZ cord-315656-asvf4roo 178 12 employing employ VBG cord-315656-asvf4roo 178 13 the the DT cord-315656-asvf4roo 178 14 anti anti JJ cord-315656-asvf4roo 178 15 - - JJ cord-315656-asvf4roo 178 16 inflammatory inflammatory JJ cord-315656-asvf4roo 178 17 and and CC cord-315656-asvf4roo 178 18 antiapoptotic antiapoptotic JJ cord-315656-asvf4roo 178 19 effects effect NNS cord-315656-asvf4roo 178 20 of of IN cord-315656-asvf4roo 178 21 mesenchymal mesenchymal JJ cord-315656-asvf4roo 178 22 stem stem NN cord-315656-asvf4roo 178 23 cells cell NNS cord-315656-asvf4roo 178 24 ( ( -LRB- cord-315656-asvf4roo 178 25 MSCs msc NNS cord-315656-asvf4roo 178 26 ) ) -RRB- cord-315656-asvf4roo 178 27 , , , cord-315656-asvf4roo 178 28 which which WDT cord-315656-asvf4roo 178 29 can can MD cord-315656-asvf4roo 178 30 repair repair VB cord-315656-asvf4roo 178 31 lung lung NN cord-315656-asvf4roo 178 32 epithelial epithelial JJ cord-315656-asvf4roo 178 33 cell cell NN cord-315656-asvf4roo 178 34 damage damage NN cord-315656-asvf4roo 178 35 and and CC cord-315656-asvf4roo 178 36 facilitate facilitate VB cord-315656-asvf4roo 178 37 alveolar alveolar JJ cord-315656-asvf4roo 178 38 fluid fluid JJ cord-315656-asvf4roo 178 39 clearance clearance NN cord-315656-asvf4roo 178 40 ( ( -LRB- cord-315656-asvf4roo 178 41 54 54 CD cord-315656-asvf4roo 178 42 ) ) -RRB- cord-315656-asvf4roo 178 43 . . . cord-315656-asvf4roo 179 1 So so RB cord-315656-asvf4roo 179 2 far far RB cord-315656-asvf4roo 179 3 , , , cord-315656-asvf4roo 179 4 they -PRON- PRP cord-315656-asvf4roo 179 5 are be VBP cord-315656-asvf4roo 179 6 still still RB cord-315656-asvf4roo 179 7 in in IN cord-315656-asvf4roo 179 8 clinical clinical JJ cord-315656-asvf4roo 179 9 trials trial NNS cord-315656-asvf4roo 179 10 and and CC cord-315656-asvf4roo 179 11 are be VBP cord-315656-asvf4roo 179 12 waiting wait VBG cord-315656-asvf4roo 179 13 for for IN cord-315656-asvf4roo 179 14 evaluation evaluation NN cord-315656-asvf4roo 179 15 . . . cord-315656-asvf4roo 180 1 In in IN cord-315656-asvf4roo 180 2 the the DT cord-315656-asvf4roo 180 3 other other JJ cord-315656-asvf4roo 180 4 way way NN cord-315656-asvf4roo 180 5 , , , cord-315656-asvf4roo 180 6 fortunately fortunately RB cord-315656-asvf4roo 180 7 , , , cord-315656-asvf4roo 180 8 the the DT cord-315656-asvf4roo 180 9 development development NN cord-315656-asvf4roo 180 10 of of IN cord-315656-asvf4roo 180 11 vaccines vaccine NNS cord-315656-asvf4roo 180 12 for for IN cord-315656-asvf4roo 180 13 the the DT cord-315656-asvf4roo 180 14 public public NN cord-315656-asvf4roo 180 15 has have VBZ cord-315656-asvf4roo 180 16 been be VBN cord-315656-asvf4roo 180 17 right right JJ cord-315656-asvf4roo 180 18 on on IN cord-315656-asvf4roo 180 19 the the DT cord-315656-asvf4roo 180 20 track track NN cord-315656-asvf4roo 180 21 ( ( -LRB- cord-315656-asvf4roo 180 22 105 105 CD cord-315656-asvf4roo 180 23 - - SYM cord-315656-asvf4roo 180 24 108 108 CD cord-315656-asvf4roo 180 25 ) ) -RRB- cord-315656-asvf4roo 180 26 , , , cord-315656-asvf4roo 180 27 some some DT cord-315656-asvf4roo 180 28 of of IN cord-315656-asvf4roo 180 29 which which WDT cord-315656-asvf4roo 180 30 have have VBP cord-315656-asvf4roo 180 31 been be VBN cord-315656-asvf4roo 180 32 under under IN cord-315656-asvf4roo 180 33 Phase Phase NNP cord-315656-asvf4roo 180 34 III iii CD cord-315656-asvf4roo 180 35 Clinical clinical JJ cord-315656-asvf4roo 180 36 Trials trial NNS cord-315656-asvf4roo 180 37 . . . cord-315656-asvf4roo 181 1 Lastly lastly RB cord-315656-asvf4roo 181 2 , , , cord-315656-asvf4roo 181 3 while while IN cord-315656-asvf4roo 181 4 we -PRON- PRP cord-315656-asvf4roo 181 5 are be VBP cord-315656-asvf4roo 181 6 talking talk VBG cord-315656-asvf4roo 181 7 about about IN cord-315656-asvf4roo 181 8 the the DT cord-315656-asvf4roo 181 9 acute acute JJ cord-315656-asvf4roo 181 10 or or CC cord-315656-asvf4roo 181 11 chronic chronic JJ cord-315656-asvf4roo 181 12 immune immune JJ cord-315656-asvf4roo 181 13 imbalance imbalance NN cord-315656-asvf4roo 181 14 , , , cord-315656-asvf4roo 181 15 it -PRON- PRP cord-315656-asvf4roo 181 16 is be VBZ cord-315656-asvf4roo 181 17 better well JJR cord-315656-asvf4roo 181 18 to to TO cord-315656-asvf4roo 181 19 appreciate appreciate VB cord-315656-asvf4roo 181 20 that that IN cord-315656-asvf4roo 181 21 keeping keep VBG cord-315656-asvf4roo 181 22 the the DT cord-315656-asvf4roo 181 23 immune immune JJ cord-315656-asvf4roo 181 24 system system NN cord-315656-asvf4roo 181 25 in in IN cord-315656-asvf4roo 181 26 balance balance NN cord-315656-asvf4roo 181 27 is be VBZ cord-315656-asvf4roo 181 28 pivotal pivotal JJ cord-315656-asvf4roo 181 29 for for IN cord-315656-asvf4roo 181 30 maintaining maintain VBG cord-315656-asvf4roo 181 31 health health NN cord-315656-asvf4roo 181 32 from from IN cord-315656-asvf4roo 181 33 infections infection NNS cord-315656-asvf4roo 181 34 and and CC cord-315656-asvf4roo 181 35 other other JJ cord-315656-asvf4roo 181 36 pathogenic pathogenic JJ cord-315656-asvf4roo 181 37 agents agent NNS cord-315656-asvf4roo 181 38 . . . cord-315656-asvf4roo 182 1 To to TO cord-315656-asvf4roo 182 2 achieve achieve VB cord-315656-asvf4roo 182 3 this this DT cord-315656-asvf4roo 182 4 goal goal NN cord-315656-asvf4roo 182 5 , , , cord-315656-asvf4roo 182 6 people people NNS cord-315656-asvf4roo 182 7 should should MD cord-315656-asvf4roo 182 8 lead lead VB cord-315656-asvf4roo 182 9 a a DT cord-315656-asvf4roo 182 10 healthy healthy JJ cord-315656-asvf4roo 182 11 lifestyle lifestyle NN cord-315656-asvf4roo 182 12 , , , cord-315656-asvf4roo 182 13 with with IN cord-315656-asvf4roo 182 14 diets diet NNS cord-315656-asvf4roo 182 15 rich rich JJ cord-315656-asvf4roo 182 16 in in IN cord-315656-asvf4roo 182 17 whole whole JJ cord-315656-asvf4roo 182 18 grains grain NNS cord-315656-asvf4roo 182 19 , , , cord-315656-asvf4roo 182 20 vegetables vegetable NNS cord-315656-asvf4roo 182 21 , , , cord-315656-asvf4roo 182 22 and and CC cord-315656-asvf4roo 182 23 fruits fruit NNS cord-315656-asvf4roo 182 24 , , , cord-315656-asvf4roo 182 25 but but CC cord-315656-asvf4roo 182 26 low low JJ cord-315656-asvf4roo 182 27 in in IN cord-315656-asvf4roo 182 28 red red JJ cord-315656-asvf4roo 182 29 meat meat NN cord-315656-asvf4roo 182 30 and and CC cord-315656-asvf4roo 182 31 high high JJ cord-315656-asvf4roo 182 32 - - HYPH cord-315656-asvf4roo 182 33 fat fat NN cord-315656-asvf4roo 182 34 foods food NNS cord-315656-asvf4roo 182 35 . . . cord-315656-asvf4roo 183 1 Regular regular JJ cord-315656-asvf4roo 183 2 exercise exercise NN cord-315656-asvf4roo 183 3 and and CC cord-315656-asvf4roo 183 4 stress stress NN cord-315656-asvf4roo 183 5 relief relief NN cord-315656-asvf4roo 183 6 are be VBP cord-315656-asvf4roo 183 7 also also RB cord-315656-asvf4roo 183 8 incorporated incorporate VBN cord-315656-asvf4roo 183 9 , , , cord-315656-asvf4roo 183 10 so so IN cord-315656-asvf4roo 183 11 as as IN cord-315656-asvf4roo 183 12 to to TO cord-315656-asvf4roo 183 13 strengthen strengthen VB cord-315656-asvf4roo 183 14 our -PRON- PRP$ cord-315656-asvf4roo 183 15 immunity immunity NN cord-315656-asvf4roo 183 16 against against IN cord-315656-asvf4roo 183 17 viral viral JJ cord-315656-asvf4roo 183 18 infections infection NNS cord-315656-asvf4roo 183 19 . . . cord-315656-asvf4roo 184 1 YT YT NNP cord-315656-asvf4roo 184 2 conceived conceive VBD cord-315656-asvf4roo 184 3 the the DT cord-315656-asvf4roo 184 4 manuscript manuscript NN cord-315656-asvf4roo 184 5 . . . cord-315656-asvf4roo 185 1 JW JW NNP cord-315656-asvf4roo 185 2 and and CC cord-315656-asvf4roo 185 3 YT YT NNP cord-315656-asvf4roo 185 4 wrote write VBD cord-315656-asvf4roo 185 5 and and CC cord-315656-asvf4roo 185 6 revised revise VBD cord-315656-asvf4roo 185 7 the the DT cord-315656-asvf4roo 185 8 draft draft NN cord-315656-asvf4roo 185 9 . . . cord-315656-asvf4roo 186 1 All all DT cord-315656-asvf4roo 186 2 authors author NNS cord-315656-asvf4roo 186 3 approved approve VBD cord-315656-asvf4roo 186 4 the the DT cord-315656-asvf4roo 186 5 submission submission NN cord-315656-asvf4roo 186 6 . . . cord-315656-asvf4roo 186 7 _SP cord-315656-asvf4roo 187 1 Genomic genomic JJ cord-315656-asvf4roo 187 2 characterization characterization NN cord-315656-asvf4roo 187 3 of of IN cord-315656-asvf4roo 187 4 the the DT cord-315656-asvf4roo 187 5 2019 2019 CD cord-315656-asvf4roo 187 6 novel novel NN cord-315656-asvf4roo 187 7 human human NN cord-315656-asvf4roo 187 8 - - HYPH cord-315656-asvf4roo 187 9 pathogenic pathogenic JJ cord-315656-asvf4roo 187 10 coronavirus coronavirus NN cord-315656-asvf4roo 187 11 isolated isolate VBN cord-315656-asvf4roo 187 12 from from IN cord-315656-asvf4roo 187 13 a a DT cord-315656-asvf4roo 187 14 patient patient NN cord-315656-asvf4roo 187 15 with with IN cord-315656-asvf4roo 187 16 atypical atypical JJ cord-315656-asvf4roo 187 17 pneumonia pneumonia NN cord-315656-asvf4roo 187 18 after after IN cord-315656-asvf4roo 187 19 visiting visit VBG cord-315656-asvf4roo 187 20 Wuhan Wuhan NNP cord-315656-asvf4roo 187 21 Structure Structure NNP cord-315656-asvf4roo 187 22 , , , cord-315656-asvf4roo 187 23 function function NN cord-315656-asvf4roo 187 24 , , , cord-315656-asvf4roo 187 25 and and CC cord-315656-asvf4roo 187 26 evolution evolution NN cord-315656-asvf4roo 187 27 of of IN cord-315656-asvf4roo 187 28 coronavirus coronavirus NN cord-315656-asvf4roo 187 29 spike spike NN cord-315656-asvf4roo 187 30 proteins protein NNS cord-315656-asvf4roo 187 31 Cryo Cryo NNP cord-315656-asvf4roo 187 32 - - HYPH cord-315656-asvf4roo 187 33 EM EM NNP cord-315656-asvf4roo 187 34 structure structure NN cord-315656-asvf4roo 187 35 of of IN cord-315656-asvf4roo 187 36 the the DT cord-315656-asvf4roo 187 37 2019-nCoV 2019-ncov CD cord-315656-asvf4roo 187 38 spike spike NN cord-315656-asvf4roo 187 39 in in IN cord-315656-asvf4roo 187 40 the the DT cord-315656-asvf4roo 187 41 prefusion prefusion NN cord-315656-asvf4roo 187 42 conformation conformation NN cord-315656-asvf4roo 187 43 Characterization characterization NN cord-315656-asvf4roo 187 44 of of IN cord-315656-asvf4roo 187 45 spike spike NN cord-315656-asvf4roo 187 46 glycoprotein glycoprotein NN cord-315656-asvf4roo 187 47 of of IN cord-315656-asvf4roo 187 48 SARS SARS NNP cord-315656-asvf4roo 187 49 - - HYPH cord-315656-asvf4roo 187 50 CoV-2 CoV-2 NNP cord-315656-asvf4roo 187 51 on on IN cord-315656-asvf4roo 187 52 virus virus NN cord-315656-asvf4roo 187 53 entry entry NN cord-315656-asvf4roo 187 54 and and CC cord-315656-asvf4roo 187 55 its -PRON- PRP$ cord-315656-asvf4roo 187 56 immune immune JJ cord-315656-asvf4roo 187 57 cross cross NN cord-315656-asvf4roo 187 58 - - NN cord-315656-asvf4roo 187 59 reactivity reactivity NN cord-315656-asvf4roo 187 60 with with IN cord-315656-asvf4roo 187 61 SARS SARS NNP cord-315656-asvf4roo 187 62 - - HYPH cord-315656-asvf4roo 187 63 CoV CoV NNP cord-315656-asvf4roo 187 64 Structural structural JJ cord-315656-asvf4roo 187 65 basis basis NN cord-315656-asvf4roo 187 66 for for IN cord-315656-asvf4roo 187 67 the the DT cord-315656-asvf4roo 187 68 recognition recognition NN cord-315656-asvf4roo 187 69 of of IN cord-315656-asvf4roo 187 70 SARS SARS NNP cord-315656-asvf4roo 187 71 - - HYPH cord-315656-asvf4roo 187 72 CoV-2 CoV-2 NNP cord-315656-asvf4roo 187 73 by by IN cord-315656-asvf4roo 187 74 full full JJ cord-315656-asvf4roo 187 75 - - HYPH cord-315656-asvf4roo 187 76 length length NN cord-315656-asvf4roo 187 77 human human JJ cord-315656-asvf4roo 187 78 ACE2 ace2 NN cord-315656-asvf4roo 188 1 The the DT cord-315656-asvf4roo 188 2 renin renin NN cord-315656-asvf4roo 188 3 - - HYPH cord-315656-asvf4roo 188 4 angiotensin angiotensin NN cord-315656-asvf4roo 188 5 system system NN cord-315656-asvf4roo 188 6 in in IN cord-315656-asvf4roo 188 7 cardiovascular cardiovascular JJ cord-315656-asvf4roo 188 8 autonomic autonomic JJ cord-315656-asvf4roo 188 9 control control NN cord-315656-asvf4roo 188 10 : : : cord-315656-asvf4roo 188 11 recent recent JJ cord-315656-asvf4roo 188 12 developments development NNS cord-315656-asvf4roo 188 13 and and CC cord-315656-asvf4roo 188 14 clinical clinical JJ cord-315656-asvf4roo 188 15 implications implication NNS cord-315656-asvf4roo 189 1 Angiotensinconverting angiotensinconverting NN cord-315656-asvf4roo 189 2 enzyme enzyme NN cord-315656-asvf4roo 189 3 2 2 CD cord-315656-asvf4roo 189 4 is be VBZ cord-315656-asvf4roo 189 5 a a DT cord-315656-asvf4roo 189 6 functional functional JJ cord-315656-asvf4roo 189 7 receptor receptor NN cord-315656-asvf4roo 189 8 for for IN cord-315656-asvf4roo 189 9 the the DT cord-315656-asvf4roo 189 10 SARS SARS NNP cord-315656-asvf4roo 189 11 coronavirus coronavirus NN cord-315656-asvf4roo 189 12 Clinical clinical JJ cord-315656-asvf4roo 189 13 features feature NNS cord-315656-asvf4roo 189 14 of of IN cord-315656-asvf4roo 189 15 patients patient NNS cord-315656-asvf4roo 189 16 infected infect VBN cord-315656-asvf4roo 189 17 with with IN cord-315656-asvf4roo 189 18 2019 2019 CD cord-315656-asvf4roo 189 19 novel novel JJ cord-315656-asvf4roo 189 20 coronavirus coronavirus NN cord-315656-asvf4roo 189 21 in in IN cord-315656-asvf4roo 189 22 Wuhan Wuhan NNP cord-315656-asvf4roo 189 23 Genomic Genomic NNP cord-315656-asvf4roo 189 24 characterisation characterisation NN cord-315656-asvf4roo 189 25 and and CC cord-315656-asvf4roo 189 26 epidemiology epidemiology NN cord-315656-asvf4roo 189 27 of of IN cord-315656-asvf4roo 189 28 2019 2019 CD cord-315656-asvf4roo 189 29 novel novel JJ cord-315656-asvf4roo 189 30 coronavirus coronavirus NN cord-315656-asvf4roo 189 31 : : : cord-315656-asvf4roo 189 32 implications implication NNS cord-315656-asvf4roo 189 33 for for IN cord-315656-asvf4roo 189 34 virus virus NN cord-315656-asvf4roo 189 35 origins origin NNS cord-315656-asvf4roo 189 36 and and CC cord-315656-asvf4roo 189 37 receptor receptor NN cord-315656-asvf4roo 189 38 binding bind VBG cord-315656-asvf4roo 189 39 Tissue tissue NN cord-315656-asvf4roo 189 40 distribution distribution NN cord-315656-asvf4roo 189 41 of of IN cord-315656-asvf4roo 189 42 ACE2 ACE2 NNP cord-315656-asvf4roo 189 43 protein protein NN cord-315656-asvf4roo 189 44 , , , cord-315656-asvf4roo 189 45 the the DT cord-315656-asvf4roo 189 46 functional functional JJ cord-315656-asvf4roo 189 47 receptor receptor NN cord-315656-asvf4roo 189 48 for for IN cord-315656-asvf4roo 189 49 SARS SARS NNP cord-315656-asvf4roo 189 50 coronavirus coronavirus NN cord-315656-asvf4roo 189 51 . . . cord-315656-asvf4roo 190 1 A a DT cord-315656-asvf4roo 190 2 first first JJ cord-315656-asvf4roo 190 3 step step NN cord-315656-asvf4roo 190 4 in in IN cord-315656-asvf4roo 190 5 understanding understand VBG cord-315656-asvf4roo 190 6 SARS SARS NNP cord-315656-asvf4roo 190 7 pathogenesis pathogenesis NN cord-315656-asvf4roo 191 1 SARS SARS NNP cord-315656-asvf4roo 191 2 - - HYPH cord-315656-asvf4roo 191 3 CoV-2 CoV-2 NNP cord-315656-asvf4roo 191 4 entry entry NN cord-315656-asvf4roo 191 5 factors factor NNS cord-315656-asvf4roo 191 6 are be VBP cord-315656-asvf4roo 191 7 highly highly RB cord-315656-asvf4roo 191 8 expressed express VBN cord-315656-asvf4roo 191 9 in in IN cord-315656-asvf4roo 191 10 nasal nasal JJ cord-315656-asvf4roo 191 11 epithelial epithelial JJ cord-315656-asvf4roo 191 12 cells cell NNS cord-315656-asvf4roo 191 13 together together RB cord-315656-asvf4roo 191 14 with with IN cord-315656-asvf4roo 191 15 innate innate JJ cord-315656-asvf4roo 191 16 immune immune JJ cord-315656-asvf4roo 191 17 genes gene NNS cord-315656-asvf4roo 191 18 Single single JJ cord-315656-asvf4roo 191 19 - - HYPH cord-315656-asvf4roo 191 20 cell cell NN cord-315656-asvf4roo 191 21 RNA rna NN cord-315656-asvf4roo 191 22 expression expression NN cord-315656-asvf4roo 191 23 profiling profiling NN cord-315656-asvf4roo 191 24 of of IN cord-315656-asvf4roo 191 25 ACE2 ACE2 NNP cord-315656-asvf4roo 191 26 , , , cord-315656-asvf4roo 192 1 the the DT cord-315656-asvf4roo 192 2 receptor receptor NN cord-315656-asvf4roo 192 3 of of IN cord-315656-asvf4roo 192 4 SARS SARS NNP cord-315656-asvf4roo 192 5 - - HYPH cord-315656-asvf4roo 192 6 CoV-2 CoV-2 NNP cord-315656-asvf4roo 192 7 Single single JJ cord-315656-asvf4roo 192 8 cell cell NN cord-315656-asvf4roo 192 9 analysis analysis NN cord-315656-asvf4roo 192 10 of of IN cord-315656-asvf4roo 192 11 ACE2 ACE2 NNP cord-315656-asvf4roo 192 12 expression expression NN cord-315656-asvf4roo 192 13 reveals reveal VBZ cord-315656-asvf4roo 192 14 the the DT cord-315656-asvf4roo 192 15 potential potential JJ cord-315656-asvf4roo 192 16 targets target NNS cord-315656-asvf4roo 192 17 for for IN cord-315656-asvf4roo 192 18 2019-nCoV 2019-ncov CD cord-315656-asvf4roo 192 19 SARS SARS NNP cord-315656-asvf4roo 192 20 - - HYPH cord-315656-asvf4roo 192 21 CoV-2 CoV-2 NNP cord-315656-asvf4roo 192 22 receptor receptor NN cord-315656-asvf4roo 192 23 ACE2 ACE2 NNP cord-315656-asvf4roo 192 24 is be VBZ cord-315656-asvf4roo 192 25 an an DT cord-315656-asvf4roo 192 26 interferon interferon NN cord-315656-asvf4roo 192 27 - - HYPH cord-315656-asvf4roo 192 28 stimulated stimulate VBN cord-315656-asvf4roo 192 29 gene gene NN cord-315656-asvf4roo 192 30 in in IN cord-315656-asvf4roo 192 31 human human JJ cord-315656-asvf4roo 192 32 airway airway NN cord-315656-asvf4roo 192 33 epithelial epithelial JJ cord-315656-asvf4roo 192 34 cells cell NNS cord-315656-asvf4roo 192 35 and and CC cord-315656-asvf4roo 192 36 is be VBZ cord-315656-asvf4roo 192 37 detected detect VBN cord-315656-asvf4roo 192 38 in in IN cord-315656-asvf4roo 192 39 specific specific JJ cord-315656-asvf4roo 192 40 cell cell NN cord-315656-asvf4roo 192 41 subsets subset NNS cord-315656-asvf4roo 192 42 across across IN cord-315656-asvf4roo 192 43 tissues tissue NNS cord-315656-asvf4roo 192 44 Single single JJ cord-315656-asvf4roo 192 45 - - HYPH cord-315656-asvf4roo 192 46 cell cell NN cord-315656-asvf4roo 192 47 RNA RNA NNP cord-315656-asvf4roo 192 48 - - HYPH cord-315656-asvf4roo 192 49 seq seq NNP cord-315656-asvf4roo 192 50 data data NN cord-315656-asvf4roo 192 51 analysis analysis NN cord-315656-asvf4roo 192 52 on on IN cord-315656-asvf4roo 192 53 the the DT cord-315656-asvf4roo 192 54 receptor receptor NN cord-315656-asvf4roo 192 55 ACE2 ACE2 NNP cord-315656-asvf4roo 192 56 expression expression NN cord-315656-asvf4roo 192 57 reveals reveal VBZ cord-315656-asvf4roo 192 58 the the DT cord-315656-asvf4roo 192 59 potential potential JJ cord-315656-asvf4roo 192 60 risk risk NN cord-315656-asvf4roo 192 61 of of IN cord-315656-asvf4roo 192 62 different different JJ cord-315656-asvf4roo 192 63 human human JJ cord-315656-asvf4roo 192 64 organs organ NNS cord-315656-asvf4roo 192 65 vulnerable vulnerable JJ cord-315656-asvf4roo 192 66 to to IN cord-315656-asvf4roo 192 67 2019-nCoV 2019-ncov CD cord-315656-asvf4roo 192 68 infection infection NN cord-315656-asvf4roo 193 1 Specific specific JJ cord-315656-asvf4roo 193 2 ACE2 ACE2 NNP cord-315656-asvf4roo 193 3 expression expression NN cord-315656-asvf4roo 193 4 in in IN cord-315656-asvf4roo 193 5 cholangiocytes cholangiocyte NNS cord-315656-asvf4roo 193 6 may may MD cord-315656-asvf4roo 193 7 cause cause VB cord-315656-asvf4roo 193 8 liver liver NN cord-315656-asvf4roo 193 9 damage damage NN cord-315656-asvf4roo 193 10 after after IN cord-315656-asvf4roo 193 11 2019-nCoV 2019-ncov CD cord-315656-asvf4roo 193 12 infection infection NN cord-315656-asvf4roo 194 1 The the DT cord-315656-asvf4roo 194 2 novel novel JJ cord-315656-asvf4roo 194 3 severe severe JJ cord-315656-asvf4roo 194 4 acute acute JJ cord-315656-asvf4roo 194 5 respiratory respiratory JJ cord-315656-asvf4roo 194 6 syndrome syndrome NN cord-315656-asvf4roo 194 7 coronavirus coronavirus NN cord-315656-asvf4roo 194 8 2 2 CD cord-315656-asvf4roo 195 1 ( ( -LRB- cord-315656-asvf4roo 195 2 SARS SARS NNP cord-315656-asvf4roo 195 3 - - HYPH cord-315656-asvf4roo 195 4 CoV-2 CoV-2 NNP cord-315656-asvf4roo 195 5 ) ) -RRB- cord-315656-asvf4roo 195 6 directly directly RB cord-315656-asvf4roo 195 7 decimates decimate VBZ cord-315656-asvf4roo 195 8 human human JJ cord-315656-asvf4roo 195 9 spleens spleen NNS cord-315656-asvf4roo 195 10 and and CC cord-315656-asvf4roo 195 11 lymph lymph NN cord-315656-asvf4roo 195 12 nodes node NNS cord-315656-asvf4roo 195 13 . . . cord-315656-asvf4roo 196 1 medRxiv medRxiv NNS cord-315656-asvf4roo 196 2 High high JJ cord-315656-asvf4roo 196 3 expression expression NN cord-315656-asvf4roo 196 4 of of IN cord-315656-asvf4roo 196 5 ACE2 ACE2 NNP cord-315656-asvf4roo 196 6 receptor receptor NN cord-315656-asvf4roo 196 7 of of IN cord-315656-asvf4roo 196 8 2019-nCoV 2019-ncov CD cord-315656-asvf4roo 196 9 on on IN cord-315656-asvf4roo 196 10 the the DT cord-315656-asvf4roo 196 11 epithelial epithelial JJ cord-315656-asvf4roo 196 12 cells cell NNS cord-315656-asvf4roo 196 13 of of IN cord-315656-asvf4roo 196 14 oral oral JJ cord-315656-asvf4roo 196 15 mucosa mucosa JJ cord-315656-asvf4roo 196 16 Infection infection NN cord-315656-asvf4roo 196 17 of of IN cord-315656-asvf4roo 196 18 bat bat NN cord-315656-asvf4roo 196 19 and and CC cord-315656-asvf4roo 196 20 human human JJ cord-315656-asvf4roo 196 21 intestinal intestinal JJ cord-315656-asvf4roo 196 22 organoids organoid NNS cord-315656-asvf4roo 196 23 by by IN cord-315656-asvf4roo 196 24 SARS SARS NNP cord-315656-asvf4roo 196 25 - - HYPH cord-315656-asvf4roo 196 26 CoV-2 CoV-2 NNP cord-315656-asvf4roo 197 1 The the DT cord-315656-asvf4roo 197 2 spatial spatial JJ cord-315656-asvf4roo 197 3 and and CC cord-315656-asvf4roo 197 4 cell cell NN cord-315656-asvf4roo 197 5 - - HYPH cord-315656-asvf4roo 197 6 type type NN cord-315656-asvf4roo 197 7 distribution distribution NN cord-315656-asvf4roo 197 8 of of IN cord-315656-asvf4roo 197 9 SARS SARS NNP cord-315656-asvf4roo 197 10 - - HYPH cord-315656-asvf4roo 197 11 CoV-2 CoV-2 NNP cord-315656-asvf4roo 197 12 receptor receptor NN cord-315656-asvf4roo 197 13 ACE2 ACE2 NNP cord-315656-asvf4roo 197 14 in in IN cord-315656-asvf4roo 197 15 human human NN cord-315656-asvf4roo 197 16 and and CC cord-315656-asvf4roo 197 17 mouse mouse NN cord-315656-asvf4roo 197 18 brain brain NN cord-315656-asvf4roo 198 1 bioRxiv biorxiv DT cord-315656-asvf4roo 198 2 Effects effect NNS cord-315656-asvf4roo 198 3 of of IN cord-315656-asvf4roo 198 4 COVID-19 COVID-19 NNP cord-315656-asvf4roo 198 5 on on IN cord-315656-asvf4roo 198 6 the the DT cord-315656-asvf4roo 198 7 nervous nervous JJ cord-315656-asvf4roo 198 8 system system NN cord-315656-asvf4roo 198 9 Neurologic Neurologic NNP cord-315656-asvf4roo 198 10 Alterations alteration NNS cord-315656-asvf4roo 198 11 Due due IN cord-315656-asvf4roo 198 12 to to IN cord-315656-asvf4roo 198 13 Respiratory respiratory JJ cord-315656-asvf4roo 198 14 Virus Virus NNP cord-315656-asvf4roo 198 15 Infections Infections NNPS cord-315656-asvf4roo 198 16 Human Human NNP cord-315656-asvf4roo 198 17 coronaviruses coronaviruse NNS cord-315656-asvf4roo 198 18 and and CC cord-315656-asvf4roo 198 19 other other JJ cord-315656-asvf4roo 198 20 respiratory respiratory JJ cord-315656-asvf4roo 198 21 viruses virus NNS cord-315656-asvf4roo 198 22 : : : cord-315656-asvf4roo 198 23 underestimated underestimate VBN cord-315656-asvf4roo 198 24 opportunistic opportunistic JJ cord-315656-asvf4roo 198 25 pathogens pathogen NNS cord-315656-asvf4roo 198 26 of of IN cord-315656-asvf4roo 198 27 the the DT cord-315656-asvf4roo 198 28 central central JJ cord-315656-asvf4roo 198 29 nervous nervous JJ cord-315656-asvf4roo 198 30 system system NN cord-315656-asvf4roo 198 31 ? ? . cord-315656-asvf4roo 199 1 Viruses virus NNS cord-315656-asvf4roo 200 1 Neurological neurological JJ cord-315656-asvf4roo 200 2 manifestations manifestation NNS cord-315656-asvf4roo 200 3 in in IN cord-315656-asvf4roo 200 4 severe severe JJ cord-315656-asvf4roo 200 5 acute acute JJ cord-315656-asvf4roo 200 6 respiratory respiratory JJ cord-315656-asvf4roo 200 7 syndrome syndrome NN cord-315656-asvf4roo 201 1 The the DT cord-315656-asvf4roo 201 2 clinical clinical JJ cord-315656-asvf4roo 201 3 pathology pathology NN cord-315656-asvf4roo 201 4 of of IN cord-315656-asvf4roo 201 5 severe severe JJ cord-315656-asvf4roo 201 6 acute acute JJ cord-315656-asvf4roo 201 7 respiratory respiratory JJ cord-315656-asvf4roo 201 8 syndrome syndrome NN cord-315656-asvf4roo 201 9 . . . cord-315656-asvf4roo 202 1 ( ( -LRB- cord-315656-asvf4roo 202 2 SARS SARS NNP cord-315656-asvf4roo 202 3 ) ) -RRB- cord-315656-asvf4roo 202 4 : : : cord-315656-asvf4roo 202 5 a a DT cord-315656-asvf4roo 202 6 report report NN cord-315656-asvf4roo 202 7 from from IN cord-315656-asvf4roo 202 8 China China NNP cord-315656-asvf4roo 203 1 Possible possible JJ cord-315656-asvf4roo 203 2 central central JJ cord-315656-asvf4roo 203 3 nervous nervous JJ cord-315656-asvf4roo 203 4 system system NN cord-315656-asvf4roo 203 5 infection infection NN cord-315656-asvf4roo 203 6 by by IN cord-315656-asvf4roo 203 7 SARS SARS NNP cord-315656-asvf4roo 203 8 coronavirus coronavirus NN cord-315656-asvf4roo 203 9 Neurological neurological JJ cord-315656-asvf4roo 203 10 complications complication NNS cord-315656-asvf4roo 203 11 during during IN cord-315656-asvf4roo 203 12 treatment treatment NN cord-315656-asvf4roo 203 13 of of IN cord-315656-asvf4roo 203 14 middle middle NNP cord-315656-asvf4roo 203 15 east east NNP cord-315656-asvf4roo 203 16 respiratory respiratory JJ cord-315656-asvf4roo 203 17 syndrome syndrome NN cord-315656-asvf4roo 203 18 Neurological neurological JJ cord-315656-asvf4roo 203 19 manifestations manifestation NNS cord-315656-asvf4roo 203 20 in in IN cord-315656-asvf4roo 203 21 COVID-19 covid-19 NN cord-315656-asvf4roo 203 22 caused cause VBN cord-315656-asvf4roo 203 23 by by IN cord-315656-asvf4roo 203 24 SARS SARS NNP cord-315656-asvf4roo 203 25 - - HYPH cord-315656-asvf4roo 203 26 CoV-2 CoV-2 NNP cord-315656-asvf4roo 203 27 Evidence evidence NN cord-315656-asvf4roo 203 28 of of IN cord-315656-asvf4roo 203 29 the the DT cord-315656-asvf4roo 203 30 COVID-19 COVID-19 NNP cord-315656-asvf4roo 203 31 virus virus NN cord-315656-asvf4roo 203 32 targeting target VBG cord-315656-asvf4roo 203 33 the the DT cord-315656-asvf4roo 203 34 CNS CNS NNP cord-315656-asvf4roo 203 35 : : : cord-315656-asvf4roo 203 36 tissue tissue NN cord-315656-asvf4roo 203 37 distribution distribution NN cord-315656-asvf4roo 203 38 , , , cord-315656-asvf4roo 203 39 host host NN cord-315656-asvf4roo 203 40 - - HYPH cord-315656-asvf4roo 203 41 virus virus NN cord-315656-asvf4roo 203 42 interaction interaction NN cord-315656-asvf4roo 203 43 , , , cord-315656-asvf4roo 203 44 and and CC cord-315656-asvf4roo 203 45 proposed propose VBD cord-315656-asvf4roo 203 46 neurotropic neurotropic NNP cord-315656-asvf4roo 203 47 mechanisms mechanism NNS cord-315656-asvf4roo 203 48 Nervous nervous JJ cord-315656-asvf4roo 203 49 system system NN cord-315656-asvf4roo 203 50 involvement involvement NN cord-315656-asvf4roo 203 51 after after IN cord-315656-asvf4roo 203 52 infection infection NN cord-315656-asvf4roo 203 53 with with IN cord-315656-asvf4roo 203 54 COVID-19 COVID-19 NNP cord-315656-asvf4roo 203 55 and and CC cord-315656-asvf4roo 203 56 other other JJ cord-315656-asvf4roo 203 57 coronaviruses coronaviruse NNS cord-315656-asvf4roo 204 1 The the DT cord-315656-asvf4roo 204 2 neuroinvasive neuroinvasive JJ cord-315656-asvf4roo 204 3 potential potential NN cord-315656-asvf4roo 204 4 of of IN cord-315656-asvf4roo 204 5 SARS SARS NNP cord-315656-asvf4roo 204 6 - - HYPH cord-315656-asvf4roo 204 7 CoV2 CoV2 NNP cord-315656-asvf4roo 204 8 may may MD cord-315656-asvf4roo 204 9 play play VB cord-315656-asvf4roo 204 10 a a DT cord-315656-asvf4roo 204 11 role role NN cord-315656-asvf4roo 204 12 in in IN cord-315656-asvf4roo 204 13 the the DT cord-315656-asvf4roo 204 14 respiratory respiratory JJ cord-315656-asvf4roo 204 15 failure failure NN cord-315656-asvf4roo 204 16 of of IN cord-315656-asvf4roo 204 17 COVID-19 covid-19 JJ cord-315656-asvf4roo 204 18 patients patient NNS cord-315656-asvf4roo 204 19 Neurologic neurologic JJ cord-315656-asvf4roo 204 20 manifestations manifestation NNS cord-315656-asvf4roo 204 21 of of IN cord-315656-asvf4roo 204 22 hospitalized hospitalize VBN cord-315656-asvf4roo 204 23 patients patient NNS cord-315656-asvf4roo 204 24 with with IN cord-315656-asvf4roo 204 25 coronavirus coronavirus NN cord-315656-asvf4roo 204 26 disease disease NN cord-315656-asvf4roo 204 27 2019 2019 CD cord-315656-asvf4roo 204 28 in in IN cord-315656-asvf4roo 204 29 Wuhan Wuhan NNP cord-315656-asvf4roo 204 30 , , , cord-315656-asvf4roo 204 31 China China NNP cord-315656-asvf4roo 204 32 Neurologic Neurologic NNP cord-315656-asvf4roo 204 33 features feature VBZ cord-315656-asvf4roo 204 34 in in IN cord-315656-asvf4roo 204 35 severe severe JJ cord-315656-asvf4roo 204 36 SARS SARS NNP cord-315656-asvf4roo 204 37 - - HYPH cord-315656-asvf4roo 204 38 CoV-2 CoV-2 NNP cord-315656-asvf4roo 204 39 infection infection NN cord-315656-asvf4roo 205 1 A a DT cord-315656-asvf4roo 205 2 first first JJ cord-315656-asvf4roo 205 3 case case NN cord-315656-asvf4roo 205 4 of of IN cord-315656-asvf4roo 205 5 meningitis meningitis NN cord-315656-asvf4roo 205 6 / / SYM cord-315656-asvf4roo 205 7 encephalitis encephalitis NN cord-315656-asvf4roo 205 8 associated associate VBN cord-315656-asvf4roo 205 9 with with IN cord-315656-asvf4roo 205 10 SARS SARS NNP cord-315656-asvf4roo 205 11 - - HYPH cord-315656-asvf4roo 205 12 Coronavirus-2 Coronavirus-2 NNP cord-315656-asvf4roo 205 13 First First NNP cord-315656-asvf4roo 205 14 case case NN cord-315656-asvf4roo 205 15 of of IN cord-315656-asvf4roo 205 16 2019 2019 CD cord-315656-asvf4roo 205 17 novel novel JJ cord-315656-asvf4roo 205 18 coronavirus coronavirus NN cord-315656-asvf4roo 205 19 disease disease NN cord-315656-asvf4roo 205 20 with with IN cord-315656-asvf4roo 205 21 Encephalitis Encephalitis NNP cord-315656-asvf4roo 205 22 High high JJ cord-315656-asvf4roo 205 23 risk risk NN cord-315656-asvf4roo 205 24 of of IN cord-315656-asvf4roo 205 25 thrombosis thrombosis NN cord-315656-asvf4roo 205 26 in in IN cord-315656-asvf4roo 205 27 patients patient NNS cord-315656-asvf4roo 205 28 with with IN cord-315656-asvf4roo 205 29 severe severe JJ cord-315656-asvf4roo 205 30 SARS SARS NNP cord-315656-asvf4roo 205 31 - - HYPH cord-315656-asvf4roo 205 32 CoV-2 CoV-2 NNP cord-315656-asvf4roo 205 33 infection infection NN cord-315656-asvf4roo 205 34 : : : cord-315656-asvf4roo 206 1 a a DT cord-315656-asvf4roo 206 2 multicenter multicenter JJ cord-315656-asvf4roo 206 3 prospective prospective JJ cord-315656-asvf4roo 206 4 cohort cohort NN cord-315656-asvf4roo 206 5 study study NN cord-315656-asvf4roo 206 6 Endothelial endothelial JJ cord-315656-asvf4roo 206 7 cell cell NN cord-315656-asvf4roo 206 8 infection infection NN cord-315656-asvf4roo 206 9 and and CC cord-315656-asvf4roo 206 10 endotheliitis endotheliitis NN cord-315656-asvf4roo 206 11 in in IN cord-315656-asvf4roo 206 12 COVID-19 COVID-19 NNP cord-315656-asvf4roo 206 13 Self Self NNP cord-315656-asvf4roo 206 14 - - HYPH cord-315656-asvf4roo 206 15 reported report VBN cord-315656-asvf4roo 206 16 olfactory olfactory NN cord-315656-asvf4roo 206 17 and and CC cord-315656-asvf4roo 206 18 taste taste NN cord-315656-asvf4roo 206 19 disorders disorder NNS cord-315656-asvf4roo 206 20 in in IN cord-315656-asvf4roo 206 21 SARS SARS NNP cord-315656-asvf4roo 206 22 - - HYPH cord-315656-asvf4roo 206 23 CoV-2 CoV-2 NNP cord-315656-asvf4roo 206 24 patients patient NNS cord-315656-asvf4roo 206 25 : : : cord-315656-asvf4roo 207 1 a a DT cord-315656-asvf4roo 207 2 crosssectional crosssectional JJ cord-315656-asvf4roo 207 3 study study NN cord-315656-asvf4roo 207 4 Early early JJ cord-315656-asvf4roo 207 5 recovery recovery NN cord-315656-asvf4roo 207 6 following follow VBG cord-315656-asvf4roo 207 7 new new JJ cord-315656-asvf4roo 207 8 onset onset NN cord-315656-asvf4roo 207 9 anosmia anosmia NN cord-315656-asvf4roo 207 10 during during IN cord-315656-asvf4roo 207 11 the the DT cord-315656-asvf4roo 207 12 COVID-19 COVID-19 NNP cord-315656-asvf4roo 207 13 pandemic pandemic NN cord-315656-asvf4roo 208 1 -an -an : cord-315656-asvf4roo 208 2 observational observational JJ cord-315656-asvf4roo 208 3 cohort cohort NN cord-315656-asvf4roo 208 4 study study NN cord-315656-asvf4roo 208 5 Non non JJ cord-315656-asvf4roo 208 6 - - JJ cord-315656-asvf4roo 208 7 neuronal neuronal JJ cord-315656-asvf4roo 208 8 expression expression NN cord-315656-asvf4roo 208 9 of of IN cord-315656-asvf4roo 208 10 SARS SARS NNP cord-315656-asvf4roo 208 11 - - HYPH cord-315656-asvf4roo 208 12 CoV-2 CoV-2 NNP cord-315656-asvf4roo 208 13 entry entry NN cord-315656-asvf4roo 208 14 genes gene NNS cord-315656-asvf4roo 208 15 in in IN cord-315656-asvf4roo 208 16 the the DT cord-315656-asvf4roo 208 17 olfactory olfactory JJ cord-315656-asvf4roo 208 18 system system NN cord-315656-asvf4roo 209 1 suggests suggest VBZ cord-315656-asvf4roo 209 2 mechanisms mechanism NNS cord-315656-asvf4roo 209 3 underlying underlie VBG cord-315656-asvf4roo 209 4 COVID-19-associated covid-19-associate VBN cord-315656-asvf4roo 209 5 anosmia anosmia NN cord-315656-asvf4roo 209 6 Inflammatory inflammatory JJ cord-315656-asvf4roo 209 7 olfactory olfactory JJ cord-315656-asvf4roo 209 8 neuropathy neuropathy NN cord-315656-asvf4roo 209 9 in in IN cord-315656-asvf4roo 209 10 two two CD cord-315656-asvf4roo 209 11 patients patient NNS cord-315656-asvf4roo 209 12 with with IN cord-315656-asvf4roo 209 13 COVID-19 COVID-19 NNP cord-315656-asvf4roo 209 14 COVID-19 COVID-19 NNP cord-315656-asvf4roo 209 15 : : : cord-315656-asvf4roo 209 16 gastrointestinal gastrointestinal JJ cord-315656-asvf4roo 209 17 manifestations manifestation NNS cord-315656-asvf4roo 209 18 and and CC cord-315656-asvf4roo 209 19 potential potential JJ cord-315656-asvf4roo 209 20 fecal fecal JJ cord-315656-asvf4roo 209 21 - - HYPH cord-315656-asvf4roo 209 22 oral oral JJ cord-315656-asvf4roo 209 23 transmission transmission NN cord-315656-asvf4roo 209 24 Neurological neurological JJ cord-315656-asvf4roo 209 25 manifestations manifestation NNS cord-315656-asvf4roo 209 26 of of IN cord-315656-asvf4roo 209 27 patients patient NNS cord-315656-asvf4roo 209 28 with with IN cord-315656-asvf4roo 209 29 COVID-19 covid-19 JJ cord-315656-asvf4roo 209 30 : : : cord-315656-asvf4roo 209 31 potential potential JJ cord-315656-asvf4roo 209 32 routes route NNS cord-315656-asvf4roo 209 33 of of IN cord-315656-asvf4roo 209 34 SARS SARS NNP cord-315656-asvf4roo 209 35 - - HYPH cord-315656-asvf4roo 209 36 CoV-2 CoV-2 NNP cord-315656-asvf4roo 209 37 neuroinvasion neuroinvasion NN cord-315656-asvf4roo 209 38 from from IN cord-315656-asvf4roo 209 39 the the DT cord-315656-asvf4roo 209 40 periphery periphery NN cord-315656-asvf4roo 209 41 to to IN cord-315656-asvf4roo 209 42 the the DT cord-315656-asvf4roo 209 43 brain brain NN cord-315656-asvf4roo 209 44 Neurotropic Neurotropic NNP cord-315656-asvf4roo 209 45 virus virus NN cord-315656-asvf4roo 209 46 infections infection NNS cord-315656-asvf4roo 209 47 as as IN cord-315656-asvf4roo 209 48 the the DT cord-315656-asvf4roo 209 49 cause cause NN cord-315656-asvf4roo 209 50 of of IN cord-315656-asvf4roo 209 51 immediate immediate JJ cord-315656-asvf4roo 209 52 and and CC cord-315656-asvf4roo 209 53 delayed delayed JJ cord-315656-asvf4roo 209 54 neuropathology neuropathology NN cord-315656-asvf4roo 209 55 Pathogenic pathogenic JJ cord-315656-asvf4roo 209 56 human human JJ cord-315656-asvf4roo 209 57 coronavirus coronavirus NN cord-315656-asvf4roo 209 58 infections infection NNS cord-315656-asvf4roo 209 59 : : : cord-315656-asvf4roo 210 1 causes cause NNS cord-315656-asvf4roo 210 2 and and CC cord-315656-asvf4roo 210 3 consequences consequence NNS cord-315656-asvf4roo 210 4 of of IN cord-315656-asvf4roo 210 5 cytokine cytokine NN cord-315656-asvf4roo 210 6 storm storm NN cord-315656-asvf4roo 210 7 and and CC cord-315656-asvf4roo 210 8 immunopathology immunopathology NN cord-315656-asvf4roo 210 9 Plasma plasma NN cord-315656-asvf4roo 210 10 inflammatory inflammatory JJ cord-315656-asvf4roo 210 11 cytokines cytokine NNS cord-315656-asvf4roo 210 12 and and CC cord-315656-asvf4roo 210 13 chemokines chemokine NNS cord-315656-asvf4roo 210 14 in in IN cord-315656-asvf4roo 210 15 severe severe JJ cord-315656-asvf4roo 210 16 acute acute JJ cord-315656-asvf4roo 210 17 respiratory respiratory JJ cord-315656-asvf4roo 210 18 syndrome syndrome NN cord-315656-asvf4roo 210 19 Middle Middle NNP cord-315656-asvf4roo 210 20 east east NNP cord-315656-asvf4roo 210 21 respiratory respiratory JJ cord-315656-asvf4roo 210 22 syndrome syndrome NN cord-315656-asvf4roo 210 23 : : : cord-315656-asvf4roo 211 1 emergence emergence NN cord-315656-asvf4roo 211 2 of of IN cord-315656-asvf4roo 211 3 a a DT cord-315656-asvf4roo 211 4 pathogenic pathogenic JJ cord-315656-asvf4roo 211 5 human human JJ cord-315656-asvf4roo 211 6 coronavirus coronavirus NN cord-315656-asvf4roo 211 7 MERS MERS NNP cord-315656-asvf4roo 211 8 - - HYPH cord-315656-asvf4roo 211 9 CoV cov NN cord-315656-asvf4roo 211 10 infection infection NN cord-315656-asvf4roo 211 11 in in IN cord-315656-asvf4roo 211 12 humans human NNS cord-315656-asvf4roo 211 13 is be VBZ cord-315656-asvf4roo 211 14 associated associate VBN cord-315656-asvf4roo 211 15 with with IN cord-315656-asvf4roo 211 16 a a DT cord-315656-asvf4roo 211 17 proinflammatory proinflammatory JJ cord-315656-asvf4roo 211 18 Th1 th1 NN cord-315656-asvf4roo 211 19 and and CC cord-315656-asvf4roo 211 20 Th17 Th17 NNP cord-315656-asvf4roo 211 21 cytokine cytokine NN cord-315656-asvf4roo 211 22 profile profile NN cord-315656-asvf4roo 211 23 Imbalanced imbalanced JJ cord-315656-asvf4roo 211 24 host host NN cord-315656-asvf4roo 211 25 response response NN cord-315656-asvf4roo 211 26 to to IN cord-315656-asvf4roo 211 27 SARS SARS NNP cord-315656-asvf4roo 211 28 - - HYPH cord-315656-asvf4roo 211 29 CoV-2 CoV-2 NNP cord-315656-asvf4roo 211 30 drives drive VBZ cord-315656-asvf4roo 211 31 development development NN cord-315656-asvf4roo 211 32 of of IN cord-315656-asvf4roo 211 33 COVID-19 COVID-19 NNP cord-315656-asvf4roo 211 34 Dysregulation Dysregulation NNP cord-315656-asvf4roo 211 35 of of IN cord-315656-asvf4roo 211 36 immune immune JJ cord-315656-asvf4roo 211 37 response response NN cord-315656-asvf4roo 211 38 in in IN cord-315656-asvf4roo 211 39 patients patient NNS cord-315656-asvf4roo 211 40 with with IN cord-315656-asvf4roo 211 41 COVID-19 COVID-19 NNP cord-315656-asvf4roo 211 42 in in IN cord-315656-asvf4roo 211 43 Wuhan Wuhan NNP cord-315656-asvf4roo 211 44 , , , cord-315656-asvf4roo 212 1 China China NNP cord-315656-asvf4roo 212 2 Immunopathological Immunopathological NNP cord-315656-asvf4roo 212 3 characteristics characteristic NNS cord-315656-asvf4roo 212 4 of of IN cord-315656-asvf4roo 212 5 coronavirus coronavirus NN cord-315656-asvf4roo 212 6 disease disease NN cord-315656-asvf4roo 212 7 2019 2019 CD cord-315656-asvf4roo 212 8 cases case NNS cord-315656-asvf4roo 212 9 in in IN cord-315656-asvf4roo 212 10 Guangzhou Guangzhou NNP cord-315656-asvf4roo 212 11 Pathological Pathological NNP cord-315656-asvf4roo 212 12 findings finding NNS cord-315656-asvf4roo 212 13 of of IN cord-315656-asvf4roo 212 14 COVID-19 COVID-19 NNP cord-315656-asvf4roo 212 15 associated associate VBN cord-315656-asvf4roo 212 16 with with IN cord-315656-asvf4roo 212 17 acute acute JJ cord-315656-asvf4roo 212 18 respiratory respiratory JJ cord-315656-asvf4roo 212 19 distress distress NN cord-315656-asvf4roo 212 20 syndrome syndrome NN cord-315656-asvf4roo 212 21 Aberrant aberrant JJ cord-315656-asvf4roo 212 22 pathogenic pathogenic JJ cord-315656-asvf4roo 212 23 GM GM NNP cord-315656-asvf4roo 212 24 - - HYPH cord-315656-asvf4roo 212 25 CSF+ CSF+ NNP cord-315656-asvf4roo 212 26 T T NNP cord-315656-asvf4roo 212 27 cells cell NNS cord-315656-asvf4roo 212 28 and and CC cord-315656-asvf4roo 212 29 inflammatory inflammatory JJ cord-315656-asvf4roo 212 30 CD14+CD16 CD14+CD16 NNP cord-315656-asvf4roo 212 31 + + CC cord-315656-asvf4roo 212 32 monocytes monocyte NNS cord-315656-asvf4roo 212 33 in in IN cord-315656-asvf4roo 212 34 severe severe JJ cord-315656-asvf4roo 212 35 pulmonary pulmonary JJ cord-315656-asvf4roo 212 36 syndrome syndrome NN cord-315656-asvf4roo 212 37 patients patient NNS cord-315656-asvf4roo 212 38 of of IN cord-315656-asvf4roo 212 39 a a DT cord-315656-asvf4roo 212 40 new new JJ cord-315656-asvf4roo 212 41 coronavirus coronavirus NN cord-315656-asvf4roo 212 42 COVID-19 covid-19 CD cord-315656-asvf4roo 212 43 : : : cord-315656-asvf4roo 212 44 immunopathology immunopathology NN cord-315656-asvf4roo 212 45 and and CC cord-315656-asvf4roo 212 46 its -PRON- PRP$ cord-315656-asvf4roo 212 47 implications implication NNS cord-315656-asvf4roo 212 48 for for IN cord-315656-asvf4roo 212 49 therapy therapy NN cord-315656-asvf4roo 212 50 SARS SARS NNP cord-315656-asvf4roo 212 51 : : : cord-315656-asvf4roo 212 52 systematic systematic JJ cord-315656-asvf4roo 212 53 review review NN cord-315656-asvf4roo 212 54 of of IN cord-315656-asvf4roo 212 55 treatment treatment NN cord-315656-asvf4roo 212 56 effects effect NNS cord-315656-asvf4roo 212 57 Corticosteroid Corticosteroid NNP cord-315656-asvf4roo 212 58 therapy therapy NN cord-315656-asvf4roo 212 59 for for IN cord-315656-asvf4roo 212 60 critically critically RB cord-315656-asvf4roo 212 61 ill ill JJ cord-315656-asvf4roo 212 62 patients patient NNS cord-315656-asvf4roo 212 63 with with IN cord-315656-asvf4roo 212 64 middle middle NNP cord-315656-asvf4roo 212 65 east east NNP cord-315656-asvf4roo 212 66 respiratory respiratory JJ cord-315656-asvf4roo 212 67 syndrome syndrome NN cord-315656-asvf4roo 212 68 Epidemiological epidemiological JJ cord-315656-asvf4roo 212 69 and and CC cord-315656-asvf4roo 212 70 clinical clinical JJ cord-315656-asvf4roo 212 71 characteristics characteristic NNS cord-315656-asvf4roo 212 72 of of IN cord-315656-asvf4roo 212 73 99 99 CD cord-315656-asvf4roo 212 74 cases case NNS cord-315656-asvf4roo 212 75 of of IN cord-315656-asvf4roo 212 76 2019 2019 CD cord-315656-asvf4roo 212 77 novel novel JJ cord-315656-asvf4roo 212 78 coronavirus coronavirus NN cord-315656-asvf4roo 212 79 pneumonia pneumonia NN cord-315656-asvf4roo 212 80 in in IN cord-315656-asvf4roo 212 81 Wuhan Wuhan NNP cord-315656-asvf4roo 212 82 , , , cord-315656-asvf4roo 212 83 China China NNP cord-315656-asvf4roo 212 84 : : : cord-315656-asvf4roo 212 85 a a DT cord-315656-asvf4roo 212 86 descriptive descriptive JJ cord-315656-asvf4roo 212 87 study study NN cord-315656-asvf4roo 212 88 Characteristics characteristic NNS cord-315656-asvf4roo 212 89 of of IN cord-315656-asvf4roo 212 90 lymphocyte lymphocyte NN cord-315656-asvf4roo 212 91 subsets subset NNS cord-315656-asvf4roo 212 92 and and CC cord-315656-asvf4roo 212 93 cytokines cytokine NNS cord-315656-asvf4roo 212 94 in in IN cord-315656-asvf4roo 212 95 peripheral peripheral JJ cord-315656-asvf4roo 212 96 blood blood NN cord-315656-asvf4roo 212 97 of of IN cord-315656-asvf4roo 212 98 123 123 CD cord-315656-asvf4roo 212 99 hospitalized hospitalize VBN cord-315656-asvf4roo 212 100 patients patient NNS cord-315656-asvf4roo 212 101 with with IN cord-315656-asvf4roo 212 102 2019 2019 CD cord-315656-asvf4roo 212 103 novel novel JJ cord-315656-asvf4roo 212 104 coronavirus coronavirus NN cord-315656-asvf4roo 212 105 pneumonia pneumonia NN cord-315656-asvf4roo 212 106 . . . cord-315656-asvf4roo 213 1 ( ( -LRB- cord-315656-asvf4roo 213 2 NCP NCP NNP cord-315656-asvf4roo 213 3 ) ) -RRB- cord-315656-asvf4roo 213 4 . . . cord-315656-asvf4roo 214 1 medRxiv medRxiv NNS cord-315656-asvf4roo 214 2 Clinical clinical JJ cord-315656-asvf4roo 214 3 and and CC cord-315656-asvf4roo 214 4 immunological immunological JJ cord-315656-asvf4roo 214 5 features feature NNS cord-315656-asvf4roo 214 6 of of IN cord-315656-asvf4roo 214 7 severe severe JJ cord-315656-asvf4roo 214 8 and and CC cord-315656-asvf4roo 214 9 moderate moderate JJ cord-315656-asvf4roo 214 10 coronavirus coronavirus NN cord-315656-asvf4roo 214 11 disease disease NN cord-315656-asvf4roo 214 12 2019 2019 CD cord-315656-asvf4roo 214 13 Elevated elevated JJ cord-315656-asvf4roo 214 14 levels level NNS cord-315656-asvf4roo 214 15 of of IN cord-315656-asvf4roo 214 16 IL-6 IL-6 NNP cord-315656-asvf4roo 214 17 and and CC cord-315656-asvf4roo 214 18 CRP CRP NNP cord-315656-asvf4roo 214 19 predict predict VBP cord-315656-asvf4roo 214 20 the the DT cord-315656-asvf4roo 214 21 need need NN cord-315656-asvf4roo 214 22 for for IN cord-315656-asvf4roo 214 23 mechanical mechanical JJ cord-315656-asvf4roo 214 24 ventilation ventilation NN cord-315656-asvf4roo 214 25 in in IN cord-315656-asvf4roo 214 26 COVID-19 COVID-19 NNP cord-315656-asvf4roo 214 27 Clinical clinical JJ cord-315656-asvf4roo 214 28 predictors predictor NNS cord-315656-asvf4roo 214 29 of of IN cord-315656-asvf4roo 214 30 mortality mortality NN cord-315656-asvf4roo 214 31 due due IN cord-315656-asvf4roo 214 32 to to IN cord-315656-asvf4roo 214 33 COVID-19 COVID-19 NNP cord-315656-asvf4roo 214 34 based base VBN cord-315656-asvf4roo 214 35 on on IN cord-315656-asvf4roo 214 36 an an DT cord-315656-asvf4roo 214 37 analysis analysis NN cord-315656-asvf4roo 214 38 of of IN cord-315656-asvf4roo 214 39 data datum NNS cord-315656-asvf4roo 214 40 of of IN cord-315656-asvf4roo 214 41 150 150 CD cord-315656-asvf4roo 214 42 patients patient NNS cord-315656-asvf4roo 214 43 from from IN cord-315656-asvf4roo 214 44 Wuhan Wuhan NNP cord-315656-asvf4roo 214 45 , , , cord-315656-asvf4roo 214 46 China China NNP cord-315656-asvf4roo 214 47 Cytokine Cytokine NNP cord-315656-asvf4roo 214 48 release release NN cord-315656-asvf4roo 214 49 syndrome syndrome NN cord-315656-asvf4roo 214 50 in in IN cord-315656-asvf4roo 214 51 severe severe JJ cord-315656-asvf4roo 214 52 COVID-19 COVID-19 NNP cord-315656-asvf4roo 214 53 Focus Focus NNP cord-315656-asvf4roo 214 54 shifts shift VBZ cord-315656-asvf4roo 214 55 to to IN cord-315656-asvf4roo 214 56 antibody antibody NN cord-315656-asvf4roo 214 57 cocktails cocktail NNS cord-315656-asvf4roo 214 58 for for IN cord-315656-asvf4roo 214 59 COVID-19 covid-19 JJ cord-315656-asvf4roo 214 60 cytokine cytokine NN cord-315656-asvf4roo 214 61 storm storm NN cord-315656-asvf4roo 214 62 Effective effective JJ cord-315656-asvf4roo 214 63 treatment treatment NN cord-315656-asvf4roo 214 64 of of IN cord-315656-asvf4roo 214 65 severe severe JJ cord-315656-asvf4roo 214 66 COVID-19 covid-19 JJ cord-315656-asvf4roo 214 67 patients patient NNS cord-315656-asvf4roo 214 68 with with IN cord-315656-asvf4roo 214 69 tocilizumab tocilizumab JJ cord-315656-asvf4roo 214 70 Multiple multiple JJ cord-315656-asvf4roo 214 71 organ organ NN cord-315656-asvf4roo 214 72 infection infection NN cord-315656-asvf4roo 214 73 and and CC cord-315656-asvf4roo 214 74 the the DT cord-315656-asvf4roo 214 75 pathogenesis pathogenesis NN cord-315656-asvf4roo 214 76 of of IN cord-315656-asvf4roo 214 77 SARS SARS NNP cord-315656-asvf4roo 214 78 Autopsy Autopsy NNP cord-315656-asvf4roo 214 79 of of IN cord-315656-asvf4roo 214 80 COVID-19 covid-19 JJ cord-315656-asvf4roo 214 81 victims victim NNS cord-315656-asvf4roo 214 82 in in IN cord-315656-asvf4roo 214 83 China China NNP cord-315656-asvf4roo 214 84 Coronavirus Coronavirus NNP cord-315656-asvf4roo 214 85 neurovirulence neurovirulence NN cord-315656-asvf4roo 214 86 correlates correlate VBZ cord-315656-asvf4roo 214 87 with with IN cord-315656-asvf4roo 214 88 the the DT cord-315656-asvf4roo 214 89 ability ability NN cord-315656-asvf4roo 214 90 of of IN cord-315656-asvf4roo 214 91 the the DT cord-315656-asvf4roo 214 92 virus virus NN cord-315656-asvf4roo 214 93 to to TO cord-315656-asvf4roo 214 94 induce induce VB cord-315656-asvf4roo 214 95 pro pro JJ cord-315656-asvf4roo 214 96 - - JJ cord-315656-asvf4roo 214 97 inflammatory inflammatory JJ cord-315656-asvf4roo 214 98 cytokine cytokine NN cord-315656-asvf4roo 214 99 signals signal NNS cord-315656-asvf4roo 214 100 from from IN cord-315656-asvf4roo 214 101 astrocytes astrocyte NNS cord-315656-asvf4roo 214 102 and and CC cord-315656-asvf4roo 214 103 microglia microglia JJ cord-315656-asvf4roo 214 104 Microglia Microglia NNP cord-315656-asvf4roo 214 105 are be VBP cord-315656-asvf4roo 214 106 required require VBN cord-315656-asvf4roo 214 107 for for IN cord-315656-asvf4roo 214 108 protection protection NN cord-315656-asvf4roo 214 109 against against IN cord-315656-asvf4roo 214 110 lethal lethal JJ cord-315656-asvf4roo 214 111 coronavirus coronavirus NN cord-315656-asvf4roo 214 112 encephalitis encephalitis RB cord-315656-asvf4roo 214 113 in in IN cord-315656-asvf4roo 214 114 mice mouse NNS cord-315656-asvf4roo 215 1 The the DT cord-315656-asvf4roo 215 2 role role NN cord-315656-asvf4roo 215 3 of of IN cord-315656-asvf4roo 215 4 microglia microglia NN cord-315656-asvf4roo 215 5 in in IN cord-315656-asvf4roo 215 6 viral viral JJ cord-315656-asvf4roo 215 7 encephalitis encephalitis NN cord-315656-asvf4roo 215 8 : : : cord-315656-asvf4roo 216 1 a a DT cord-315656-asvf4roo 216 2 review review NN cord-315656-asvf4roo 216 3 Neurological Neurological NNP cord-315656-asvf4roo 216 4 associations association NNS cord-315656-asvf4roo 216 5 of of IN cord-315656-asvf4roo 216 6 COVID-19 COVID-19 NNP cord-315656-asvf4roo 216 7 Does do VBZ cord-315656-asvf4roo 216 8 SARS SARS NNP cord-315656-asvf4roo 216 9 - - HYPH cord-315656-asvf4roo 216 10 CoV-2 CoV-2 NNP cord-315656-asvf4roo 216 11 infection infection NN cord-315656-asvf4roo 216 12 cause cause VBP cord-315656-asvf4roo 216 13 chronic chronic JJ cord-315656-asvf4roo 216 14 neurological neurological JJ cord-315656-asvf4roo 216 15 complications complication NNS cord-315656-asvf4roo 216 16 ? ? . cord-315656-asvf4roo 217 1 Geroscience Geroscience NNP cord-315656-asvf4roo 217 2 SARS SARS NNP cord-315656-asvf4roo 217 3 - - HYPH cord-315656-asvf4roo 217 4 CoV-2 CoV-2 NNP cord-315656-asvf4roo 218 1 : : : cord-315656-asvf4roo 218 2 at at IN cord-315656-asvf4roo 218 3 the the DT cord-315656-asvf4roo 218 4 crossroad crossroad NN cord-315656-asvf4roo 218 5 between between IN cord-315656-asvf4roo 218 6 aging age VBG cord-315656-asvf4roo 218 7 and and CC cord-315656-asvf4roo 218 8 neurodegeneration neurodegeneration NN cord-315656-asvf4roo 218 9 Impact Impact NNP cord-315656-asvf4roo 218 10 of of IN cord-315656-asvf4roo 218 11 SARS SARS NNP cord-315656-asvf4roo 218 12 - - HYPH cord-315656-asvf4roo 218 13 CoV-2 CoV-2 NNP cord-315656-asvf4roo 218 14 infection infection NN cord-315656-asvf4roo 218 15 on on IN cord-315656-asvf4roo 218 16 neurodegenerative neurodegenerative JJ cord-315656-asvf4roo 218 17 and and CC cord-315656-asvf4roo 218 18 neuropsychiatric neuropsychiatric JJ cord-315656-asvf4roo 218 19 diseases disease NNS cord-315656-asvf4roo 218 20 : : : cord-315656-asvf4roo 218 21 a a DT cord-315656-asvf4roo 218 22 delayed delay VBN cord-315656-asvf4roo 218 23 pandemic pandemic NN cord-315656-asvf4roo 218 24 Are be VBP cord-315656-asvf4roo 218 25 we -PRON- PRP cord-315656-asvf4roo 218 26 facing face VBG cord-315656-asvf4roo 218 27 a a DT cord-315656-asvf4roo 218 28 crashing crash VBG cord-315656-asvf4roo 218 29 wave wave NN cord-315656-asvf4roo 218 30 of of IN cord-315656-asvf4roo 218 31 neuropsychiatric neuropsychiatric JJ cord-315656-asvf4roo 218 32 sequelae sequela NNS cord-315656-asvf4roo 218 33 of of IN cord-315656-asvf4roo 218 34 COVID-19 COVID-19 NNP cord-315656-asvf4roo 218 35 ? ? . cord-315656-asvf4roo 219 1 Neuropsychiatric neuropsychiatric JJ cord-315656-asvf4roo 219 2 symptoms symptom NNS cord-315656-asvf4roo 219 3 and and CC cord-315656-asvf4roo 219 4 potential potential JJ cord-315656-asvf4roo 219 5 immunologic immunologic JJ cord-315656-asvf4roo 219 6 mechanisms mechanism NNS cord-315656-asvf4roo 220 1 Viral viral JJ cord-315656-asvf4roo 220 2 and and CC cord-315656-asvf4roo 220 3 inflammatory inflammatory JJ cord-315656-asvf4roo 220 4 triggers trigger NNS cord-315656-asvf4roo 220 5 of of IN cord-315656-asvf4roo 220 6 neurodegenerative neurodegenerative JJ cord-315656-asvf4roo 220 7 diseases disease NNS cord-315656-asvf4roo 221 1 Differential differential JJ cord-315656-asvf4roo 221 2 roles role NNS cord-315656-asvf4roo 221 3 of of IN cord-315656-asvf4roo 221 4 M1 M1 NNP cord-315656-asvf4roo 221 5 and and CC cord-315656-asvf4roo 221 6 M2 M2 NNP cord-315656-asvf4roo 221 7 microglia microglia NNS cord-315656-asvf4roo 221 8 in in IN cord-315656-asvf4roo 221 9 neurodegenerative neurodegenerative JJ cord-315656-asvf4roo 221 10 diseases disease NNS cord-315656-asvf4roo 221 11 Highly highly RB cord-315656-asvf4roo 221 12 pathogenic pathogenic JJ cord-315656-asvf4roo 221 13 H5N1 H5N1 NNP cord-315656-asvf4roo 221 14 influenza influenza NN cord-315656-asvf4roo 221 15 virus virus NN cord-315656-asvf4roo 221 16 can can MD cord-315656-asvf4roo 221 17 enter enter VB cord-315656-asvf4roo 221 18 the the DT cord-315656-asvf4roo 221 19 central central JJ cord-315656-asvf4roo 221 20 nervous nervous JJ cord-315656-asvf4roo 221 21 system system NN cord-315656-asvf4roo 221 22 and and CC cord-315656-asvf4roo 221 23 induce induce VB cord-315656-asvf4roo 221 24 neuroinflammation neuroinflammation NN cord-315656-asvf4roo 221 25 and and CC cord-315656-asvf4roo 221 26 neurodegeneration neurodegeneration NN cord-315656-asvf4roo 221 27 Inflammatory inflammatory JJ cord-315656-asvf4roo 221 28 effects effect NNS cord-315656-asvf4roo 221 29 of of IN cord-315656-asvf4roo 221 30 highly highly RB cord-315656-asvf4roo 221 31 pathogenic pathogenic JJ cord-315656-asvf4roo 221 32 H5N1 H5N1 NNP cord-315656-asvf4roo 221 33 influenza influenza NN cord-315656-asvf4roo 221 34 virus virus NN cord-315656-asvf4roo 221 35 infection infection NN cord-315656-asvf4roo 221 36 in in IN cord-315656-asvf4roo 221 37 the the DT cord-315656-asvf4roo 221 38 CNS CNS NNP cord-315656-asvf4roo 221 39 of of IN cord-315656-asvf4roo 221 40 mice mouse NNS cord-315656-asvf4roo 222 1 Post post JJ cord-315656-asvf4roo 222 2 - - JJ cord-315656-asvf4roo 222 3 mortem mortem JJ cord-315656-asvf4roo 222 4 analysis analysis NN cord-315656-asvf4roo 222 5 of of IN cord-315656-asvf4roo 222 6 neuroinflammatory neuroinflammatory JJ cord-315656-asvf4roo 222 7 changes change NNS cord-315656-asvf4roo 222 8 in in IN cord-315656-asvf4roo 222 9 human human JJ cord-315656-asvf4roo 222 10 Alzheimer Alzheimer NNP cord-315656-asvf4roo 222 11 's 's POS cord-315656-asvf4roo 222 12 disease disease NN cord-315656-asvf4roo 222 13 Cerebrospinal cerebrospinal NN cord-315656-asvf4roo 222 14 fluid fluid JJ cord-315656-asvf4roo 222 15 inflammatory inflammatory JJ cord-315656-asvf4roo 222 16 cytokine cytokine NN cord-315656-asvf4roo 222 17 aberrations aberration NNS cord-315656-asvf4roo 222 18 in in IN cord-315656-asvf4roo 222 19 alzheimer alzheimer NNP cord-315656-asvf4roo 222 20 's 's POS cord-315656-asvf4roo 222 21 disease disease NN cord-315656-asvf4roo 222 22 , , , cord-315656-asvf4roo 222 23 parkinson parkinson NNP cord-315656-asvf4roo 222 24 's 's POS cord-315656-asvf4roo 222 25 disease disease NN cord-315656-asvf4roo 222 26 and and CC cord-315656-asvf4roo 222 27 amyotrophic amyotrophic JJ cord-315656-asvf4roo 222 28 lateral lateral JJ cord-315656-asvf4roo 222 29 sclerosis sclerosis NN cord-315656-asvf4roo 222 30 : : : cord-315656-asvf4roo 222 31 a a DT cord-315656-asvf4roo 222 32 systematic systematic JJ cord-315656-asvf4roo 222 33 review review NN cord-315656-asvf4roo 222 34 and and CC cord-315656-asvf4roo 222 35 meta meta NNP cord-315656-asvf4roo 222 36 - - HYPH cord-315656-asvf4roo 222 37 analysis analysis NN cord-315656-asvf4roo 222 38 Proinflammatory Proinflammatory NNP cord-315656-asvf4roo 222 39 and and CC cord-315656-asvf4roo 222 40 anti anti JJ cord-315656-asvf4roo 222 41 - - JJ cord-315656-asvf4roo 222 42 inflammatory inflammatory JJ cord-315656-asvf4roo 222 43 cytokines cytokine NNS cord-315656-asvf4roo 222 44 in in IN cord-315656-asvf4roo 222 45 the the DT cord-315656-asvf4roo 222 46 CSF CSF NNP cord-315656-asvf4roo 222 47 of of IN cord-315656-asvf4roo 222 48 patients patient NNS cord-315656-asvf4roo 222 49 with with IN cord-315656-asvf4roo 222 50 Alzheimer Alzheimer NNP cord-315656-asvf4roo 222 51 's 's POS cord-315656-asvf4roo 222 52 disease disease NN cord-315656-asvf4roo 222 53 and and CC cord-315656-asvf4roo 222 54 their -PRON- PRP$ cord-315656-asvf4roo 222 55 correlation correlation NN cord-315656-asvf4roo 222 56 with with IN cord-315656-asvf4roo 222 57 cognitive cognitive JJ cord-315656-asvf4roo 222 58 decline decline NN cord-315656-asvf4roo 222 59 Neuroinflammation Neuroinflammation NNP cord-315656-asvf4roo 222 60 in in IN cord-315656-asvf4roo 222 61 Parkinson Parkinson NNP cord-315656-asvf4roo 222 62 's 's POS cord-315656-asvf4roo 222 63 disease disease NN cord-315656-asvf4roo 222 64 and and CC cord-315656-asvf4roo 222 65 its -PRON- PRP$ cord-315656-asvf4roo 222 66 potential potential NN cord-315656-asvf4roo 222 67 as as IN cord-315656-asvf4roo 222 68 therapeutic therapeutic JJ cord-315656-asvf4roo 222 69 target target NN cord-315656-asvf4roo 222 70 Role role NN cord-315656-asvf4roo 222 71 of of IN cord-315656-asvf4roo 222 72 neuroinflammation neuroinflammation NN cord-315656-asvf4roo 222 73 in in IN cord-315656-asvf4roo 222 74 amyotrophic amyotrophic JJ cord-315656-asvf4roo 222 75 lateral lateral JJ cord-315656-asvf4roo 222 76 sclerosis sclerosis NN cord-315656-asvf4roo 222 77 : : : cord-315656-asvf4roo 222 78 cellular cellular JJ cord-315656-asvf4roo 222 79 mechanisms mechanism NNS cord-315656-asvf4roo 222 80 and and CC cord-315656-asvf4roo 222 81 therapeutic therapeutic JJ cord-315656-asvf4roo 222 82 implications implication NNS cord-315656-asvf4roo 222 83 . . . cord-315656-asvf4roo 223 1 Front Front NNP cord-315656-asvf4roo 223 2 Immunol Immunol NNP cord-315656-asvf4roo 223 3 Inflammation Inflammation NNP cord-315656-asvf4roo 223 4 as as IN cord-315656-asvf4roo 223 5 a a DT cord-315656-asvf4roo 223 6 central central JJ cord-315656-asvf4roo 223 7 mechanism mechanism NN cord-315656-asvf4roo 223 8 in in IN cord-315656-asvf4roo 223 9 Alzheimer Alzheimer NNP cord-315656-asvf4roo 223 10 's 's POS cord-315656-asvf4roo 223 11 disease disease NN cord-315656-asvf4roo 223 12 Chronic chronic JJ cord-315656-asvf4roo 223 13 inflammation inflammation NN cord-315656-asvf4roo 223 14 in in IN cord-315656-asvf4roo 223 15 multiple multiple JJ cord-315656-asvf4roo 223 16 sclerosisseeing sclerosisseeing NN cord-315656-asvf4roo 223 17 what what WP cord-315656-asvf4roo 223 18 was be VBD cord-315656-asvf4roo 223 19 always always RB cord-315656-asvf4roo 223 20 there there RB cord-315656-asvf4roo 224 1 The the DT cord-315656-asvf4roo 224 2 role role NN cord-315656-asvf4roo 224 3 of of IN cord-315656-asvf4roo 224 4 microglia microglia NN cord-315656-asvf4roo 224 5 and and CC cord-315656-asvf4roo 224 6 astrocytes astrocyte NNS cord-315656-asvf4roo 224 7 in in IN cord-315656-asvf4roo 224 8 huntington huntington NNP cord-315656-asvf4roo 224 9 's 's POS cord-315656-asvf4roo 224 10 disease disease NN cord-315656-asvf4roo 225 1 Interferon interferon NN cord-315656-asvf4roo 225 2 - - HYPH cord-315656-asvf4roo 225 3 gamma gamma NN cord-315656-asvf4roo 225 4 and and CC cord-315656-asvf4roo 225 5 tumor tumor NN cord-315656-asvf4roo 225 6 necrosis necrosis NN cord-315656-asvf4roo 225 7 factor factor NN cord-315656-asvf4roo 225 8 - - HYPH cord-315656-asvf4roo 225 9 alpha alpha NN cord-315656-asvf4roo 225 10 regulate regulate VB cord-315656-asvf4roo 225 11 amyloid amyloid NN cord-315656-asvf4roo 225 12 - - HYPH cord-315656-asvf4roo 225 13 beta beta NN cord-315656-asvf4roo 225 14 plaque plaque NN cord-315656-asvf4roo 225 15 deposition deposition NN cord-315656-asvf4roo 225 16 and and CC cord-315656-asvf4roo 225 17 beta beta NN cord-315656-asvf4roo 225 18 - - HYPH cord-315656-asvf4roo 225 19 secretase secretase JJ cord-315656-asvf4roo 225 20 expression expression NN cord-315656-asvf4roo 225 21 in in IN cord-315656-asvf4roo 225 22 Swedish swedish JJ cord-315656-asvf4roo 225 23 mutant mutant JJ cord-315656-asvf4roo 225 24 APP app NN cord-315656-asvf4roo 225 25 transgenic transgenic JJ cord-315656-asvf4roo 225 26 mice mouse NNS cord-315656-asvf4roo 225 27 Interleukin-6 Interleukin-6 NNP cord-315656-asvf4roo 225 28 induces induce VBZ cord-315656-asvf4roo 225 29 Alzheimer Alzheimer NNP cord-315656-asvf4roo 225 30 - - HYPH cord-315656-asvf4roo 225 31 type type NN cord-315656-asvf4roo 225 32 phosphorylation phosphorylation NN cord-315656-asvf4roo 225 33 of of IN cord-315656-asvf4roo 225 34 tau tau NN cord-315656-asvf4roo 225 35 protein protein NN cord-315656-asvf4roo 225 36 by by IN cord-315656-asvf4roo 225 37 deregulating deregulate VBG cord-315656-asvf4roo 225 38 the the DT cord-315656-asvf4roo 225 39 cdk5 cdk5 NN cord-315656-asvf4roo 225 40 / / SYM cord-315656-asvf4roo 225 41 p35 p35 CD cord-315656-asvf4roo 225 42 pathway pathway NN cord-315656-asvf4roo 226 1 New new JJ cord-315656-asvf4roo 226 2 perspectives perspective NNS cord-315656-asvf4roo 226 3 on on IN cord-315656-asvf4roo 226 4 roles role NNS cord-315656-asvf4roo 226 5 of of IN cord-315656-asvf4roo 226 6 alpha alpha NN cord-315656-asvf4roo 226 7 - - HYPH cord-315656-asvf4roo 226 8 synuclein synuclein NNP cord-315656-asvf4roo 226 9 in in IN cord-315656-asvf4roo 226 10 parkinson parkinson NNP cord-315656-asvf4roo 226 11 's 's POS cord-315656-asvf4roo 226 12 disease disease NN cord-315656-asvf4roo 226 13 P2X7 P2X7 NNP cord-315656-asvf4roo 226 14 receptor receptor NN cord-315656-asvf4roo 226 15 is be VBZ cord-315656-asvf4roo 226 16 critical critical JJ cord-315656-asvf4roo 226 17 in in IN cord-315656-asvf4roo 226 18 alpha alpha NN cord-315656-asvf4roo 226 19 - - HYPH cord-315656-asvf4roo 226 20 synuclein synuclein NN cord-315656-asvf4roo 226 21 - - HYPH cord-315656-asvf4roo 226 22 mediated mediate VBN cord-315656-asvf4roo 226 23 microglial microglial JJ cord-315656-asvf4roo 226 24 NADPH NADPH NNP cord-315656-asvf4roo 226 25 oxidase oxidase NN cord-315656-asvf4roo 226 26 activation activation NN cord-315656-asvf4roo 226 27 CXCL12 CXCL12 NNP cord-315656-asvf4roo 226 28 is be VBZ cord-315656-asvf4roo 226 29 involved involve VBN cord-315656-asvf4roo 226 30 in in IN cord-315656-asvf4roo 226 31 alpha alpha NN cord-315656-asvf4roo 226 32 - - HYPH cord-315656-asvf4roo 226 33 synuclein synuclein NN cord-315656-asvf4roo 226 34 - - HYPH cord-315656-asvf4roo 226 35 triggered trigger VBN cord-315656-asvf4roo 226 36 neuroinflammation neuroinflammation NN cord-315656-asvf4roo 226 37 of of IN cord-315656-asvf4roo 226 38 Parkinson Parkinson NNP cord-315656-asvf4roo 226 39 's 's POS cord-315656-asvf4roo 226 40 disease disease NN cord-315656-asvf4roo 227 1 Extracellular Extracellular NNP cord-315656-asvf4roo 227 2 mutant mutant NN cord-315656-asvf4roo 227 3 SOD1 SOD1 NNP cord-315656-asvf4roo 227 4 induces induce VBZ cord-315656-asvf4roo 227 5 microglial microglial RB cord-315656-asvf4roo 227 6 - - HYPH cord-315656-asvf4roo 227 7 mediated mediate VBN cord-315656-asvf4roo 227 8 motoneuron motoneuron NNP cord-315656-asvf4roo 227 9 injury injury NN cord-315656-asvf4roo 227 10 Inflammatory inflammatory JJ cord-315656-asvf4roo 227 11 intrathecal intrathecal JJ cord-315656-asvf4roo 227 12 profiles profile NNS cord-315656-asvf4roo 227 13 and and CC cord-315656-asvf4roo 227 14 cortical cortical JJ cord-315656-asvf4roo 227 15 damage damage NN cord-315656-asvf4roo 227 16 in in IN cord-315656-asvf4roo 227 17 multiple multiple JJ cord-315656-asvf4roo 227 18 sclerosis sclerosis NN cord-315656-asvf4roo 227 19 Role role NN cord-315656-asvf4roo 227 20 of of IN cord-315656-asvf4roo 227 21 microglial microglial NNP cord-315656-asvf4roo 227 22 m1 m1 NNP cord-315656-asvf4roo 227 23 / / SYM cord-315656-asvf4roo 227 24 m2 m2 NNP cord-315656-asvf4roo 227 25 polarization polarization NN cord-315656-asvf4roo 227 26 in in IN cord-315656-asvf4roo 227 27 relapse relapse NN cord-315656-asvf4roo 227 28 and and CC cord-315656-asvf4roo 227 29 remission remission NN cord-315656-asvf4roo 227 30 of of IN cord-315656-asvf4roo 227 31 psychiatric psychiatric JJ cord-315656-asvf4roo 227 32 disorders disorder NNS cord-315656-asvf4roo 227 33 and and CC cord-315656-asvf4roo 227 34 diseases disease NNS cord-315656-asvf4roo 227 35 Elevated elevate VBN cord-315656-asvf4roo 227 36 interleukin-2 interleukin-2 IN cord-315656-asvf4roo 227 37 , , , cord-315656-asvf4roo 227 38 interleukin-6 interleukin-6 NNP cord-315656-asvf4roo 227 39 and and CC cord-315656-asvf4roo 227 40 interleukin-8 interleukin-8 JJ cord-315656-asvf4roo 227 41 serum serum NN cord-315656-asvf4roo 227 42 levels level NNS cord-315656-asvf4roo 227 43 in in IN cord-315656-asvf4roo 227 44 neurolepticfree neurolepticfree NNP cord-315656-asvf4roo 227 45 schizophrenia schizophrenia NNP cord-315656-asvf4roo 227 46 : : : cord-315656-asvf4roo 227 47 association association NN cord-315656-asvf4roo 227 48 with with IN cord-315656-asvf4roo 227 49 psychopathology psychopathology NN cord-315656-asvf4roo 227 50 Elevated Elevated NNP cord-315656-asvf4roo 227 51 interleukin-6 interleukin-6 NNP cord-315656-asvf4roo 227 52 in in IN cord-315656-asvf4roo 227 53 the the DT cord-315656-asvf4roo 227 54 cerebrospinal cerebrospinal JJ cord-315656-asvf4roo 227 55 fluid fluid NN cord-315656-asvf4roo 227 56 of of IN cord-315656-asvf4roo 227 57 a a DT cord-315656-asvf4roo 227 58 previously previously RB cord-315656-asvf4roo 227 59 delineated delineate VBN cord-315656-asvf4roo 227 60 schizophrenia schizophrenia NN cord-315656-asvf4roo 227 61 subtype subtype NN cord-315656-asvf4roo 227 62 CXCR4-activated CXCR4-activated NNP cord-315656-asvf4roo 227 63 astrocyte astrocyte NNP cord-315656-asvf4roo 227 64 glutamate glutamate NN cord-315656-asvf4roo 227 65 release release NN cord-315656-asvf4roo 227 66 via via IN cord-315656-asvf4roo 227 67 TNFalpha TNFalpha NNS cord-315656-asvf4roo 227 68 : : : cord-315656-asvf4roo 227 69 amplification amplification NN cord-315656-asvf4roo 227 70 by by IN cord-315656-asvf4roo 227 71 microglia microglia NN cord-315656-asvf4roo 227 72 triggers trigger VBZ cord-315656-asvf4roo 227 73 neurotoxicity neurotoxicity NN cord-315656-asvf4roo 227 74 Psychiatric psychiatric JJ cord-315656-asvf4roo 227 75 and and CC cord-315656-asvf4roo 227 76 neuropsychiatric neuropsychiatric JJ cord-315656-asvf4roo 227 77 presentations presentation NNS cord-315656-asvf4roo 227 78 associated associate VBN cord-315656-asvf4roo 227 79 with with IN cord-315656-asvf4roo 227 80 severe severe JJ cord-315656-asvf4roo 227 81 coronavirus coronavirus NN cord-315656-asvf4roo 227 82 infections infection NNS cord-315656-asvf4roo 227 83 : : : cord-315656-asvf4roo 227 84 a a DT cord-315656-asvf4roo 227 85 systematic systematic JJ cord-315656-asvf4roo 227 86 review review NN cord-315656-asvf4roo 227 87 and and CC cord-315656-asvf4roo 227 88 meta meta NNP cord-315656-asvf4roo 227 89 - - HYPH cord-315656-asvf4roo 227 90 analysis analysis NN cord-315656-asvf4roo 227 91 with with IN cord-315656-asvf4roo 227 92 comparison comparison NN cord-315656-asvf4roo 227 93 to to IN cord-315656-asvf4roo 227 94 the the DT cord-315656-asvf4roo 227 95 COVID-19 COVID-19 NNP cord-315656-asvf4roo 227 96 pandemic pandemic NN cord-315656-asvf4roo 227 97 Altered alter VBN cord-315656-asvf4roo 227 98 mental mental JJ cord-315656-asvf4roo 227 99 status status NN cord-315656-asvf4roo 227 100 as as IN cord-315656-asvf4roo 227 101 a a DT cord-315656-asvf4roo 227 102 novel novel JJ cord-315656-asvf4roo 227 103 initial initial JJ cord-315656-asvf4roo 227 104 clinical clinical JJ cord-315656-asvf4roo 227 105 presentation presentation NN cord-315656-asvf4roo 227 106 for for IN cord-315656-asvf4roo 227 107 COVID-19 covid-19 JJ cord-315656-asvf4roo 227 108 infection infection NN cord-315656-asvf4roo 227 109 in in IN cord-315656-asvf4roo 227 110 the the DT cord-315656-asvf4roo 227 111 elderly elderly JJ cord-315656-asvf4roo 227 112 Idiopathic Idiopathic NNP cord-315656-asvf4roo 227 113 Parkinson Parkinson NNP cord-315656-asvf4roo 227 114 's 's POS cord-315656-asvf4roo 227 115 disease disease NN cord-315656-asvf4roo 227 116 : : : cord-315656-asvf4roo 227 117 possible possible JJ cord-315656-asvf4roo 227 118 routes route NNS cord-315656-asvf4roo 227 119 by by IN cord-315656-asvf4roo 227 120 which which WDT cord-315656-asvf4roo 227 121 vulnerable vulnerable JJ cord-315656-asvf4roo 227 122 neuronal neuronal JJ cord-315656-asvf4roo 227 123 types type NNS cord-315656-asvf4roo 227 124 may may MD cord-315656-asvf4roo 227 125 be be VB cord-315656-asvf4roo 227 126 subject subject JJ cord-315656-asvf4roo 227 127 to to IN cord-315656-asvf4roo 227 128 neuroinvasion neuroinvasion NN cord-315656-asvf4roo 227 129 by by IN cord-315656-asvf4roo 227 130 an an DT cord-315656-asvf4roo 227 131 unknown unknown JJ cord-315656-asvf4roo 227 132 pathogen pathogen NN cord-315656-asvf4roo 228 1 The the DT cord-315656-asvf4roo 228 2 underlying underlying JJ cord-315656-asvf4roo 228 3 mechanism mechanism NN cord-315656-asvf4roo 228 4 of of IN cord-315656-asvf4roo 228 5 prodromal prodromal JJ cord-315656-asvf4roo 228 6 PD pd NN cord-315656-asvf4roo 228 7 : : : cord-315656-asvf4roo 228 8 insights insight NNS cord-315656-asvf4roo 228 9 from from IN cord-315656-asvf4roo 228 10 the the DT cord-315656-asvf4roo 228 11 parasympathetic parasympathetic JJ cord-315656-asvf4roo 228 12 nervous nervous JJ cord-315656-asvf4roo 228 13 system system NN cord-315656-asvf4roo 228 14 and and CC cord-315656-asvf4roo 228 15 the the DT cord-315656-asvf4roo 228 16 olfactory olfactory JJ cord-315656-asvf4roo 228 17 system system NN cord-315656-asvf4roo 228 18 Transneuronal Transneuronal NNP cord-315656-asvf4roo 228 19 propagation propagation NN cord-315656-asvf4roo 228 20 of of IN cord-315656-asvf4roo 228 21 pathologic pathologic JJ cord-315656-asvf4roo 228 22 alpha alpha NN cord-315656-asvf4roo 228 23 - - HYPH cord-315656-asvf4roo 228 24 synuclein synuclein NN cord-315656-asvf4roo 228 25 from from IN cord-315656-asvf4roo 228 26 the the DT cord-315656-asvf4roo 228 27 gut gut NN cord-315656-asvf4roo 228 28 to to IN cord-315656-asvf4roo 228 29 the the DT cord-315656-asvf4roo 228 30 brain brain NN cord-315656-asvf4roo 228 31 models model NNS cord-315656-asvf4roo 228 32 parkinson parkinson NNP cord-315656-asvf4roo 228 33 's 's POS cord-315656-asvf4roo 228 34 disease disease NN cord-315656-asvf4roo 229 1 The the DT cord-315656-asvf4roo 229 2 concept concept NN cord-315656-asvf4roo 229 3 of of IN cord-315656-asvf4roo 229 4 prodromal prodromal NNP cord-315656-asvf4roo 229 5 parkinson parkinson NNP cord-315656-asvf4roo 229 6 's 's POS cord-315656-asvf4roo 229 7 disease disease NN cord-315656-asvf4roo 229 8 Dexamethasone Dexamethasone NNP cord-315656-asvf4roo 229 9 in in IN cord-315656-asvf4roo 229 10 hospitalized hospitalize VBN cord-315656-asvf4roo 229 11 patients patient NNS cord-315656-asvf4roo 229 12 with with IN cord-315656-asvf4roo 229 13 covid-19 covid-19 CD cord-315656-asvf4roo 229 14 -preliminary -preliminary JJ cord-315656-asvf4roo 229 15 report report NN cord-315656-asvf4roo 229 16 Rapid Rapid NNP cord-315656-asvf4roo 229 17 development development NN cord-315656-asvf4roo 229 18 of of IN cord-315656-asvf4roo 229 19 an an DT cord-315656-asvf4roo 229 20 inactivated inactivated JJ cord-315656-asvf4roo 229 21 vaccine vaccine NN cord-315656-asvf4roo 229 22 candidate candidate NN cord-315656-asvf4roo 229 23 for for IN cord-315656-asvf4roo 229 24 SARS SARS NNP cord-315656-asvf4roo 229 25 - - HYPH cord-315656-asvf4roo 229 26 CoV-2 CoV-2 NNP cord-315656-asvf4roo 229 27 COVID-19 covid-19 JJ cord-315656-asvf4roo 229 28 vaccine vaccine NN cord-315656-asvf4roo 229 29 development development NN cord-315656-asvf4roo 229 30 and and CC cord-315656-asvf4roo 229 31 a a DT cord-315656-asvf4roo 229 32 potential potential JJ cord-315656-asvf4roo 229 33 nanomaterial nanomaterial JJ cord-315656-asvf4roo 229 34 path path NN cord-315656-asvf4roo 229 35 forward forward RB cord-315656-asvf4roo 230 1 The the DT cord-315656-asvf4roo 230 2 COVID-19 COVID-19 NNP cord-315656-asvf4roo 230 3 vaccine vaccine NN cord-315656-asvf4roo 230 4 development development NN cord-315656-asvf4roo 230 5 landscape landscape NN cord-315656-asvf4roo 230 6 Safety Safety NNP cord-315656-asvf4roo 230 7 , , , cord-315656-asvf4roo 230 8 tolerability tolerability NN cord-315656-asvf4roo 230 9 , , , cord-315656-asvf4roo 230 10 and and CC cord-315656-asvf4roo 230 11 immunogenicity immunogenicity NN cord-315656-asvf4roo 230 12 of of IN cord-315656-asvf4roo 230 13 a a DT cord-315656-asvf4roo 230 14 recombinant recombinant JJ cord-315656-asvf4roo 230 15 adenovirus adenovirus NN cord-315656-asvf4roo 230 16 type-5 type-5 IN cord-315656-asvf4roo 230 17 vectored vectore VBN cord-315656-asvf4roo 231 1 COVID-19 covid-19 JJ cord-315656-asvf4roo 231 2 vaccine vaccine NN cord-315656-asvf4roo 231 3 : : : cord-315656-asvf4roo 231 4 a a DT cord-315656-asvf4roo 231 5 dose dose NN cord-315656-asvf4roo 231 6 - - HYPH cord-315656-asvf4roo 231 7 escalation escalation NN cord-315656-asvf4roo 231 8 , , , cord-315656-asvf4roo 231 9 open open JJ cord-315656-asvf4roo 231 10 - - HYPH cord-315656-asvf4roo 231 11 label label NN cord-315656-asvf4roo 231 12 , , , cord-315656-asvf4roo 231 13 non non JJ cord-315656-asvf4roo 231 14 - - JJ cord-315656-asvf4roo 231 15 randomised randomised JJ cord-315656-asvf4roo 231 16 , , , cord-315656-asvf4roo 231 17 firstin firstin JJ cord-315656-asvf4roo 231 18 - - HYPH cord-315656-asvf4roo 231 19 human human JJ cord-315656-asvf4roo 231 20 trial trial NN cord-315656-asvf4roo 231 21 We -PRON- PRP cord-315656-asvf4roo 231 22 apologize apologize VBP cord-315656-asvf4roo 231 23 to to IN cord-315656-asvf4roo 231 24 the the DT cord-315656-asvf4roo 231 25 authors author NNS cord-315656-asvf4roo 231 26 whose whose WP$ cord-315656-asvf4roo 231 27 work work NN cord-315656-asvf4roo 231 28 might may MD cord-315656-asvf4roo 231 29 have have VB cord-315656-asvf4roo 231 30 been be VBN cord-315656-asvf4roo 231 31 unintentionally unintentionally RB cord-315656-asvf4roo 231 32 omitted omit VBN cord-315656-asvf4roo 231 33 due due IN cord-315656-asvf4roo 231 34 to to IN cord-315656-asvf4roo 231 35 space space NN cord-315656-asvf4roo 231 36 limitations limitation NNS cord-315656-asvf4roo 231 37 . . . cord-315656-asvf4roo 232 1 The the DT cord-315656-asvf4roo 232 2 authors author NNS cord-315656-asvf4roo 232 3 declare declare VBP cord-315656-asvf4roo 232 4 that that IN cord-315656-asvf4roo 232 5 the the DT cord-315656-asvf4roo 232 6 research research NN cord-315656-asvf4roo 232 7 was be VBD cord-315656-asvf4roo 232 8 conducted conduct VBN cord-315656-asvf4roo 232 9 in in IN cord-315656-asvf4roo 232 10 the the DT cord-315656-asvf4roo 232 11 absence absence NN cord-315656-asvf4roo 232 12 of of IN cord-315656-asvf4roo 232 13 any any DT cord-315656-asvf4roo 232 14 commercial commercial JJ cord-315656-asvf4roo 232 15 or or CC cord-315656-asvf4roo 232 16 financial financial JJ cord-315656-asvf4roo 232 17 relationships relationship NNS cord-315656-asvf4roo 232 18 that that WDT cord-315656-asvf4roo 232 19 could could MD cord-315656-asvf4roo 232 20 be be VB cord-315656-asvf4roo 232 21 construed construe VBN cord-315656-asvf4roo 232 22 as as IN cord-315656-asvf4roo 232 23 a a DT cord-315656-asvf4roo 232 24 potential potential JJ cord-315656-asvf4roo 232 25 conflict conflict NN cord-315656-asvf4roo 232 26 of of IN cord-315656-asvf4roo 232 27 interest interest NN cord-315656-asvf4roo 232 28 . . . cord-315656-asvf4roo 233 1 Copyright copyright NN cord-315656-asvf4roo 233 2 © © NN cord-315656-asvf4roo 233 3 2020 2020 CD cord-315656-asvf4roo 233 4 Wu Wu NNP cord-315656-asvf4roo 233 5 and and CC cord-315656-asvf4roo 233 6 Tang Tang NNP cord-315656-asvf4roo 233 7 . . . cord-315656-asvf4roo 234 1 This this DT cord-315656-asvf4roo 234 2 is be VBZ cord-315656-asvf4roo 234 3 an an DT cord-315656-asvf4roo 234 4 open open JJ cord-315656-asvf4roo 234 5 - - HYPH cord-315656-asvf4roo 234 6 access access NN cord-315656-asvf4roo 234 7 article article NN cord-315656-asvf4roo 234 8 distributed distribute VBN cord-315656-asvf4roo 234 9 under under IN cord-315656-asvf4roo 234 10 the the DT cord-315656-asvf4roo 234 11 terms term NNS cord-315656-asvf4roo 234 12 of of IN cord-315656-asvf4roo 234 13 the the DT cord-315656-asvf4roo 234 14 Creative Creative NNP cord-315656-asvf4roo 234 15 Commons Commons NNP cord-315656-asvf4roo 234 16 Attribution Attribution NNP cord-315656-asvf4roo 234 17 License License NNP cord-315656-asvf4roo 234 18 ( ( -LRB- cord-315656-asvf4roo 234 19 CC CC NNP cord-315656-asvf4roo 234 20 BY BY NNP cord-315656-asvf4roo 234 21 ) ) -RRB- cord-315656-asvf4roo 234 22 . . . cord-315656-asvf4roo 235 1 The the DT cord-315656-asvf4roo 235 2 use use NN cord-315656-asvf4roo 235 3 , , , cord-315656-asvf4roo 235 4 distribution distribution NN cord-315656-asvf4roo 235 5 or or CC cord-315656-asvf4roo 235 6 reproduction reproduction NN cord-315656-asvf4roo 235 7 in in IN cord-315656-asvf4roo 235 8 other other JJ cord-315656-asvf4roo 235 9 forums forum NNS cord-315656-asvf4roo 235 10 is be VBZ cord-315656-asvf4roo 235 11 permitted permit VBN cord-315656-asvf4roo 235 12 , , , cord-315656-asvf4roo 235 13 provided provide VBD cord-315656-asvf4roo 235 14 the the DT cord-315656-asvf4roo 235 15 original original JJ cord-315656-asvf4roo 235 16 author(s author(s NNP cord-315656-asvf4roo 235 17 ) ) -RRB- cord-315656-asvf4roo 235 18 and and CC cord-315656-asvf4roo 235 19 the the DT cord-315656-asvf4roo 235 20 copyright copyright NN cord-315656-asvf4roo 235 21 owner(s owner(s NNP cord-315656-asvf4roo 235 22 ) ) -RRB- cord-315656-asvf4roo 235 23 are be VBP cord-315656-asvf4roo 235 24 credited credit VBN cord-315656-asvf4roo 235 25 and and CC cord-315656-asvf4roo 235 26 that that IN cord-315656-asvf4roo 235 27 the the DT cord-315656-asvf4roo 235 28 original original JJ cord-315656-asvf4roo 235 29 publication publication NN cord-315656-asvf4roo 235 30 in in IN cord-315656-asvf4roo 235 31 this this DT cord-315656-asvf4roo 235 32 journal journal NN cord-315656-asvf4roo 235 33 is be VBZ cord-315656-asvf4roo 235 34 cited cite VBN cord-315656-asvf4roo 235 35 , , , cord-315656-asvf4roo 235 36 in in IN cord-315656-asvf4roo 235 37 accordance accordance NN cord-315656-asvf4roo 235 38 with with IN cord-315656-asvf4roo 235 39 accepted accepted JJ cord-315656-asvf4roo 235 40 academic academic JJ cord-315656-asvf4roo 235 41 practice practice NN cord-315656-asvf4roo 235 42 . . . cord-315656-asvf4roo 236 1 No no DT cord-315656-asvf4roo 236 2 use use NN cord-315656-asvf4roo 236 3 , , , cord-315656-asvf4roo 236 4 distribution distribution NN cord-315656-asvf4roo 236 5 or or CC cord-315656-asvf4roo 236 6 reproduction reproduction NN cord-315656-asvf4roo 236 7 is be VBZ cord-315656-asvf4roo 236 8 permitted permit VBN cord-315656-asvf4roo 236 9 which which WDT cord-315656-asvf4roo 236 10 does do VBZ cord-315656-asvf4roo 236 11 not not RB cord-315656-asvf4roo 236 12 comply comply VB cord-315656-asvf4roo 236 13 with with IN cord-315656-asvf4roo 236 14 these these DT cord-315656-asvf4roo 236 15 terms term NNS cord-315656-asvf4roo 236 16 . . .