id	sid	tid	token	lemma	pos
cord-314109-wb45naw2	1	1	key	key	NN
cord-314109-wb45naw2	1	2	:	:	:
cord-314109-wb45naw2	2	1	cord-314109-wb45naw2	cord-314109-wb45naw2	NNS
cord-314109-wb45naw2	2	2	authors	author	NNS
cord-314109-wb45naw2	2	3	:	:	:
cord-314109-wb45naw2	2	4	Maiese	Maiese	NNP
cord-314109-wb45naw2	2	5	,	,	,
cord-314109-wb45naw2	3	1	Kenneth	Kenneth	NNP
cord-314109-wb45naw2	3	2	title	title	NN
cord-314109-wb45naw2	3	3	:	:	:
cord-314109-wb45naw2	4	1	The	the	DT
cord-314109-wb45naw2	4	2	Mechanistic	Mechanistic	NNP
cord-314109-wb45naw2	4	3	Target	Target	NNP
cord-314109-wb45naw2	4	4	of	of	IN
cord-314109-wb45naw2	4	5	Rapamycin	Rapamycin	NNP
cord-314109-wb45naw2	4	6	(	(	-LRB-
cord-314109-wb45naw2	4	7	mTOR	mTOR	NNP
cord-314109-wb45naw2	4	8	)	)	-RRB-
cord-314109-wb45naw2	4	9	:	:	:
cord-314109-wb45naw2	5	1	Novel	Novel	NNP
cord-314109-wb45naw2	5	2	Considerations	Considerations	NNPS
cord-314109-wb45naw2	5	3	as	as	IN
cord-314109-wb45naw2	5	4	an	an	DT
cord-314109-wb45naw2	5	5	Antiviral	Antiviral	NNP
cord-314109-wb45naw2	5	6	Treatment	Treatment	NNP
cord-314109-wb45naw2	5	7	date	date	NN
cord-314109-wb45naw2	5	8	:	:	:
cord-314109-wb45naw2	5	9	2020	2020	CD
cord-314109-wb45naw2	5	10	-	-	HYPH
cord-314109-wb45naw2	5	11	06	06	CD
cord-314109-wb45naw2	5	12	-	-	SYM
cord-314109-wb45naw2	5	13	17	17	CD
cord-314109-wb45naw2	5	14	journal	journal	NN
cord-314109-wb45naw2	5	15	:	:	:
cord-314109-wb45naw2	6	1	Curr	Curr	NNP
cord-314109-wb45naw2	6	2	Neurovasc	Neurovasc	NNP
cord-314109-wb45naw2	6	3	Res	Res	NNP
cord-314109-wb45naw2	6	4	DOI	doi	NN
cord-314109-wb45naw2	6	5	:	:	:
cord-314109-wb45naw2	6	6	10.2174/1567202617666200425205122	10.2174/1567202617666200425205122	CD
cord-314109-wb45naw2	6	7	sha	sha	NNP
cord-314109-wb45naw2	6	8	:	:	:
cord-314109-wb45naw2	6	9	1d8059fa1014f2808ddc7e3867ccc949dde5236f	1d8059fa1014f2808ddc7e3867ccc949dde5236f	CD
cord-314109-wb45naw2	6	10	doc_id	doc_id	CD
cord-314109-wb45naw2	6	11	:	:	:
cord-314109-wb45naw2	6	12	314109	314109	CD
cord-314109-wb45naw2	6	13	cord_uid	cord_uid	NNS
cord-314109-wb45naw2	6	14	:	:	:
cord-314109-wb45naw2	7	1	wb45naw2	wb45naw2	NNS
cord-314109-wb45naw2	8	1	Multiple	multiple	JJ
cord-314109-wb45naw2	8	2	viral	viral	JJ
cord-314109-wb45naw2	8	3	pathogens	pathogen	NNS
cord-314109-wb45naw2	8	4	can	can	MD
cord-314109-wb45naw2	8	5	pose	pose	VB
cord-314109-wb45naw2	8	6	a	a	DT
cord-314109-wb45naw2	8	7	significant	significant	JJ
cord-314109-wb45naw2	8	8	health	health	NN
cord-314109-wb45naw2	8	9	risk	risk	NN
cord-314109-wb45naw2	8	10	to	to	IN
cord-314109-wb45naw2	8	11	individuals	individual	NNS
cord-314109-wb45naw2	8	12	.	.	.
cord-314109-wb45naw2	9	1	As	as	IN
cord-314109-wb45naw2	9	2	a	a	DT
cord-314109-wb45naw2	9	3	recent	recent	JJ
cord-314109-wb45naw2	9	4	example	example	NN
cord-314109-wb45naw2	9	5	,	,	,
cord-314109-wb45naw2	9	6	the	the	DT
cord-314109-wb45naw2	9	7	β	β	NN
cord-314109-wb45naw2	9	8	-	-	HYPH
cord-314109-wb45naw2	9	9	coronavirus	coronavirus	NN
cord-314109-wb45naw2	9	10	family	family	NN
cord-314109-wb45naw2	9	11	virion	virion	NN
cord-314109-wb45naw2	9	12	,	,	,
cord-314109-wb45naw2	9	13	SARS	SARS	NNP
cord-314109-wb45naw2	9	14	-	-	HYPH
cord-314109-wb45naw2	9	15	CoV-2	CoV-2	NNP
cord-314109-wb45naw2	9	16	,	,	,
cord-314109-wb45naw2	9	17	has	have	VBZ
cord-314109-wb45naw2	9	18	quickly	quickly	RB
cord-314109-wb45naw2	9	19	evolved	evolve	VBN
cord-314109-wb45naw2	9	20	as	as	IN
cord-314109-wb45naw2	9	21	a	a	DT
cord-314109-wb45naw2	9	22	pandemic	pandemic	NN
cord-314109-wb45naw2	9	23	leading	lead	VBG
cord-314109-wb45naw2	9	24	to	to	IN
cord-314109-wb45naw2	9	25	coronavirus	coronavirus	NN
cord-314109-wb45naw2	9	26	disease	disease	NN
cord-314109-wb45naw2	9	27	2019	2019	CD
cord-314109-wb45naw2	9	28	(	(	-LRB-
cord-314109-wb45naw2	9	29	COVID-19	COVID-19	NNP
cord-314109-wb45naw2	9	30	)	)	-RRB-
cord-314109-wb45naw2	9	31	and	and	CC
cord-314109-wb45naw2	9	32	has	have	VBZ
cord-314109-wb45naw2	9	33	been	be	VBN
cord-314109-wb45naw2	9	34	declared	declare	VBN
cord-314109-wb45naw2	9	35	by	by	IN
cord-314109-wb45naw2	9	36	the	the	DT
cord-314109-wb45naw2	9	37	World	World	NNP
cord-314109-wb45naw2	9	38	Health	Health	NNP
cord-314109-wb45naw2	9	39	Organization	Organization	NNP
cord-314109-wb45naw2	9	40	as	as	IN
cord-314109-wb45naw2	9	41	a	a	DT
cord-314109-wb45naw2	9	42	Public	Public	NNP
cord-314109-wb45naw2	9	43	Health	Health	NNP
cord-314109-wb45naw2	9	44	Emergency	Emergency	NNP
cord-314109-wb45naw2	9	45	of	of	IN
cord-314109-wb45naw2	9	46	International	International	NNP
cord-314109-wb45naw2	9	47	Concern	Concern	NNP
cord-314109-wb45naw2	9	48	.	.	.
cord-314109-wb45naw2	10	1	To	to	IN
cord-314109-wb45naw2	10	2	date	date	NN
cord-314109-wb45naw2	10	3	,	,	,
cord-314109-wb45naw2	10	4	no	no	DT
cord-314109-wb45naw2	10	5	definitive	definitive	JJ
cord-314109-wb45naw2	10	6	treatment	treatment	NN
cord-314109-wb45naw2	10	7	or	or	CC
cord-314109-wb45naw2	10	8	vaccine	vaccine	NN
cord-314109-wb45naw2	10	9	application	application	NN
cord-314109-wb45naw2	10	10	exists	exist	VBZ
cord-314109-wb45naw2	10	11	for	for	IN
cord-314109-wb45naw2	10	12	COVID-19	COVID-19	NNP
cord-314109-wb45naw2	10	13	.	.	.
cord-314109-wb45naw2	11	1	Although	although	IN
cord-314109-wb45naw2	11	2	new	new	JJ
cord-314109-wb45naw2	11	3	investigations	investigation	NNS
cord-314109-wb45naw2	11	4	seek	seek	VBP
cord-314109-wb45naw2	11	5	to	to	TO
cord-314109-wb45naw2	11	6	repurpose	repurpose	VB
cord-314109-wb45naw2	11	7	existing	exist	VBG
cord-314109-wb45naw2	11	8	antiviral	antiviral	JJ
cord-314109-wb45naw2	11	9	treatments	treatment	NNS
cord-314109-wb45naw2	11	10	for	for	IN
cord-314109-wb45naw2	11	11	COVID-19	COVID-19	NNP
cord-314109-wb45naw2	11	12	,	,	,
cord-314109-wb45naw2	11	13	innovative	innovative	JJ
cord-314109-wb45naw2	11	14	treatment	treatment	NN
cord-314109-wb45naw2	11	15	strategies	strategy	NNS
cord-314109-wb45naw2	11	16	not	not	RB
cord-314109-wb45naw2	11	17	normally	normally	RB
cord-314109-wb45naw2	11	18	considered	consider	VBN
cord-314109-wb45naw2	11	19	to	to	TO
cord-314109-wb45naw2	11	20	have	have	VB
cord-314109-wb45naw2	11	21	antiviral	antiviral	JJ
cord-314109-wb45naw2	11	22	capabilities	capability	NNS
cord-314109-wb45naw2	11	23	may	may	MD
cord-314109-wb45naw2	11	24	be	be	VB
cord-314109-wb45naw2	11	25	critical	critical	JJ
cord-314109-wb45naw2	11	26	to	to	TO
cord-314109-wb45naw2	11	27	address	address	VB
cord-314109-wb45naw2	11	28	this	this	DT
cord-314109-wb45naw2	11	29	global	global	JJ
cord-314109-wb45naw2	11	30	concern	concern	NN
cord-314109-wb45naw2	11	31	.	.	.
cord-314109-wb45naw2	12	1	One	one	CD
cord-314109-wb45naw2	12	2	such	such	JJ
cord-314109-wb45naw2	12	3	avenue	avenue	NN
cord-314109-wb45naw2	12	4	that	that	WDT
cord-314109-wb45naw2	12	5	may	may	MD
cord-314109-wb45naw2	12	6	prove	prove	VB
cord-314109-wb45naw2	12	7	to	to	TO
cord-314109-wb45naw2	12	8	be	be	VB
cord-314109-wb45naw2	12	9	exceedingly	exceedingly	RB
cord-314109-wb45naw2	12	10	fruitful	fruitful	JJ
cord-314109-wb45naw2	12	11	and	and	CC
cord-314109-wb45naw2	12	12	offer	offer	VBP
cord-314109-wb45naw2	12	13	exciting	exciting	JJ
cord-314109-wb45naw2	12	14	potential	potential	NN
cord-314109-wb45naw2	12	15	as	as	IN
cord-314109-wb45naw2	12	16	new	new	JJ
cord-314109-wb45naw2	12	17	antiviral	antiviral	JJ
cord-314109-wb45naw2	12	18	therapy	therapy	NN
cord-314109-wb45naw2	12	19	involves	involve	VBZ
cord-314109-wb45naw2	12	20	the	the	DT
cord-314109-wb45naw2	12	21	mechanistic	mechanistic	JJ
cord-314109-wb45naw2	12	22	target	target	NN
cord-314109-wb45naw2	12	23	of	of	IN
cord-314109-wb45naw2	12	24	rapamycin	rapamycin	NNP
cord-314109-wb45naw2	12	25	(	(	-LRB-
cord-314109-wb45naw2	12	26	mTOR	mTOR	NNP
cord-314109-wb45naw2	12	27	)	)	-RRB-
cord-314109-wb45naw2	12	28	and	and	CC
cord-314109-wb45naw2	12	29	its	-PRON-	PRP$
cord-314109-wb45naw2	12	30	associated	associated	JJ
cord-314109-wb45naw2	12	31	pathways	pathway	NNS
cord-314109-wb45naw2	12	32	of	of	IN
cord-314109-wb45naw2	12	33	mTOR	mTOR	NNP
cord-314109-wb45naw2	12	34	Complex	Complex	NNP
cord-314109-wb45naw2	12	35	1	1	CD
cord-314109-wb45naw2	12	36	(	(	-LRB-
cord-314109-wb45naw2	12	37	mTORC1	mTORC1	NNP
cord-314109-wb45naw2	12	38	)	)	-RRB-
cord-314109-wb45naw2	12	39	,	,	,
cord-314109-wb45naw2	12	40	mTOR	mTOR	NNP
cord-314109-wb45naw2	12	41	Complex	Complex	NNP
cord-314109-wb45naw2	12	42	2	2	CD
cord-314109-wb45naw2	12	43	(	(	-LRB-
cord-314109-wb45naw2	12	44	mTORC2	mTORC2	NNPS
cord-314109-wb45naw2	12	45	)	)	-RRB-
cord-314109-wb45naw2	12	46	,	,	,
cord-314109-wb45naw2	12	47	and	and	CC
cord-314109-wb45naw2	12	48	AMP	AMP	NNP
cord-314109-wb45naw2	12	49	activated	activate	VBD
cord-314109-wb45naw2	12	50	protein	protein	NN
cord-314109-wb45naw2	12	51	kinase	kinase	NN
cord-314109-wb45naw2	12	52	(	(	-LRB-
cord-314109-wb45naw2	12	53	AMPK	AMPK	NNP
cord-314109-wb45naw2	12	54	)	)	-RRB-
cord-314109-wb45naw2	12	55	.	.	.
cord-314109-wb45naw2	13	1	Recent	recent	JJ
cord-314109-wb45naw2	13	2	work	work	NN
cord-314109-wb45naw2	13	3	has	have	VBZ
cord-314109-wb45naw2	13	4	shown	show	VBN
cord-314109-wb45naw2	13	5	that	that	IN
cord-314109-wb45naw2	13	6	mTOR	mTOR	NNP
cord-314109-wb45naw2	13	7	pathways	pathway	NNS
cord-314109-wb45naw2	13	8	in	in	IN
cord-314109-wb45naw2	13	9	conjunction	conjunction	NN
cord-314109-wb45naw2	13	10	with	with	IN
cord-314109-wb45naw2	13	11	AMPK	AMPK	NNP
cord-314109-wb45naw2	13	12	may	may	MD
cord-314109-wb45naw2	13	13	offer	offer	VB
cord-314109-wb45naw2	13	14	valuable	valuable	JJ
cord-314109-wb45naw2	13	15	targets	target	NNS
cord-314109-wb45naw2	13	16	to	to	TO
cord-314109-wb45naw2	13	17	control	control	VB
cord-314109-wb45naw2	13	18	cell	cell	NN
cord-314109-wb45naw2	13	19	injury	injury	NN
cord-314109-wb45naw2	13	20	,	,	,
cord-314109-wb45naw2	13	21	oxidative	oxidative	JJ
cord-314109-wb45naw2	13	22	stress	stress	NN
cord-314109-wb45naw2	13	23	,	,	,
cord-314109-wb45naw2	13	24	mitochondrial	mitochondrial	JJ
cord-314109-wb45naw2	13	25	dysfunction	dysfunction	NN
cord-314109-wb45naw2	13	26	,	,	,
cord-314109-wb45naw2	13	27	and	and	CC
cord-314109-wb45naw2	13	28	the	the	DT
cord-314109-wb45naw2	13	29	onset	onset	NN
cord-314109-wb45naw2	13	30	of	of	IN
cord-314109-wb45naw2	13	31	hyperinflammation	hyperinflammation	NN
cord-314109-wb45naw2	13	32	,	,	,
cord-314109-wb45naw2	13	33	a	a	DT
cord-314109-wb45naw2	13	34	significant	significant	JJ
cord-314109-wb45naw2	13	35	disability	disability	NN
cord-314109-wb45naw2	13	36	associated	associate	VBN
cord-314109-wb45naw2	13	37	with	with	IN
cord-314109-wb45naw2	13	38	COVID-19	COVID-19	NNP
cord-314109-wb45naw2	13	39	.	.	.
cord-314109-wb45naw2	14	1	Furthermore	furthermore	RB
cord-314109-wb45naw2	14	2	,	,	,
cord-314109-wb45naw2	14	3	pathways	pathway	NNS
cord-314109-wb45naw2	14	4	that	that	WDT
cord-314109-wb45naw2	14	5	can	can	MD
cord-314109-wb45naw2	14	6	activate	activate	VB
cord-314109-wb45naw2	14	7	mTOR	mTOR	NNP
cord-314109-wb45naw2	14	8	may	may	MD
cord-314109-wb45naw2	14	9	be	be	VB
cord-314109-wb45naw2	14	10	necessary	necessary	JJ
cord-314109-wb45naw2	14	11	for	for	IN
cord-314109-wb45naw2	14	12	anti	anti	JJ
cord-314109-wb45naw2	14	13	-	-	JJ
cord-314109-wb45naw2	14	14	hepatitis	hepatitis	JJ
cord-314109-wb45naw2	14	15	C	c	NN
cord-314109-wb45naw2	14	16	activity	activity	NN
cord-314109-wb45naw2	14	17	,	,	,
cord-314109-wb45naw2	14	18	reduction	reduction	NN
cord-314109-wb45naw2	14	19	of	of	IN
cord-314109-wb45naw2	14	20	influenza	influenza	NN
cord-314109-wb45naw2	14	21	A	a	DT
cord-314109-wb45naw2	14	22	virus	virus	NN
cord-314109-wb45naw2	14	23	replication	replication	NN
cord-314109-wb45naw2	14	24	,	,	,
cord-314109-wb45naw2	14	25	and	and	CC
cord-314109-wb45naw2	14	26	vital	vital	JJ
cord-314109-wb45naw2	14	27	for	for	IN
cord-314109-wb45naw2	14	28	type-1	type-1	NN
cord-314109-wb45naw2	14	29	interferon	interferon	NN
cord-314109-wb45naw2	14	30	responses	response	NNS
cord-314109-wb45naw2	14	31	with	with	IN
cord-314109-wb45naw2	14	32	influenza	influenza	NN
cord-314109-wb45naw2	14	33	vaccination	vaccination	NN
cord-314109-wb45naw2	14	34	.	.	.
cord-314109-wb45naw2	15	1	Yet	yet	RB
cord-314109-wb45naw2	15	2	,	,	,
cord-314109-wb45naw2	15	3	important	important	JJ
cord-314109-wb45naw2	15	4	considerations	consideration	NNS
cord-314109-wb45naw2	15	5	for	for	IN
cord-314109-wb45naw2	15	6	the	the	DT
cord-314109-wb45naw2	15	7	development	development	NN
cord-314109-wb45naw2	15	8	of	of	IN
cord-314109-wb45naw2	15	9	safe	safe	JJ
cord-314109-wb45naw2	15	10	and	and	CC
cord-314109-wb45naw2	15	11	effective	effective	JJ
cord-314109-wb45naw2	15	12	antiviral	antiviral	JJ
cord-314109-wb45naw2	15	13	therapy	therapy	NN
cord-314109-wb45naw2	15	14	with	with	IN
cord-314109-wb45naw2	15	15	mTOR	mTOR	NNP
cord-314109-wb45naw2	15	16	pathways	pathway	NNS
cord-314109-wb45naw2	15	17	exist	exist	VBP
cord-314109-wb45naw2	15	18	.	.	.
cord-314109-wb45naw2	16	1	Under	under	IN
cord-314109-wb45naw2	16	2	some	some	DT
cord-314109-wb45naw2	16	3	conditions	condition	NNS
cord-314109-wb45naw2	16	4	,	,	,
cord-314109-wb45naw2	16	5	mTOR	mTOR	NNP
cord-314109-wb45naw2	16	6	can	can	MD
cord-314109-wb45naw2	16	7	act	act	VB
cord-314109-wb45naw2	16	8	as	as	IN
cord-314109-wb45naw2	16	9	a	a	DT
cord-314109-wb45naw2	16	10	double	double	JJ
cord-314109-wb45naw2	16	11	edge	edge	NN
cord-314109-wb45naw2	16	12	sword	sword	NN
cord-314109-wb45naw2	16	13	and	and	CC
cord-314109-wb45naw2	16	14	participate	participate	VB
cord-314109-wb45naw2	16	15	in	in	IN
cord-314109-wb45naw2	16	16	virion	virion	NN
cord-314109-wb45naw2	16	17	replication	replication	NN
cord-314109-wb45naw2	16	18	and	and	CC
cord-314109-wb45naw2	16	19	virion	virion	NN
cord-314109-wb45naw2	16	20	release	release	NN
cord-314109-wb45naw2	16	21	from	from	IN
cord-314109-wb45naw2	16	22	cells	cell	NNS
cord-314109-wb45naw2	16	23	.	.	.
cord-314109-wb45naw2	17	1	Future	future	JJ
cord-314109-wb45naw2	17	2	work	work	NN
cord-314109-wb45naw2	17	3	with	with	IN
cord-314109-wb45naw2	17	4	mTOR	mTOR	NNP
cord-314109-wb45naw2	17	5	as	as	IN
cord-314109-wb45naw2	17	6	a	a	DT
cord-314109-wb45naw2	17	7	potential	potential	JJ
cord-314109-wb45naw2	17	8	antiviral	antiviral	JJ
cord-314109-wb45naw2	17	9	target	target	NN
cord-314109-wb45naw2	17	10	is	be	VBZ
cord-314109-wb45naw2	17	11	highly	highly	RB
cord-314109-wb45naw2	17	12	warranted	warrant	VBN
cord-314109-wb45naw2	17	13	and	and	CC
cord-314109-wb45naw2	17	14	with	with	IN
cord-314109-wb45naw2	17	15	a	a	DT
cord-314109-wb45naw2	17	16	greater	great	JJR
cord-314109-wb45naw2	17	17	understanding	understanding	NN
cord-314109-wb45naw2	17	18	of	of	IN
cord-314109-wb45naw2	17	19	this	this	DT
cord-314109-wb45naw2	17	20	novel	novel	JJ
cord-314109-wb45naw2	17	21	pathway	pathway	NN
cord-314109-wb45naw2	17	22	,	,	,
cord-314109-wb45naw2	17	23	new	new	JJ
cord-314109-wb45naw2	17	24	treatments	treatment	NNS
cord-314109-wb45naw2	17	25	against	against	IN
cord-314109-wb45naw2	17	26	several	several	JJ
cord-314109-wb45naw2	17	27	viral	viral	JJ
cord-314109-wb45naw2	17	28	pathogens	pathogen	NNS
cord-314109-wb45naw2	17	29	may	may	MD
cord-314109-wb45naw2	17	30	successfully	successfully	RB
cord-314109-wb45naw2	17	31	emerge	emerge	VB
cord-314109-wb45naw2	17	32	.	.	.
cord-314109-wb45naw2	18	1	Coronaviruses	coronaviruse	NNS
cord-314109-wb45naw2	18	2	are	be	VBP
cord-314109-wb45naw2	18	3	viruses	virus	NNS
cord-314109-wb45naw2	18	4	that	that	WDT
cord-314109-wb45naw2	18	5	can	can	MD
cord-314109-wb45naw2	18	6	affect	affect	VB
cord-314109-wb45naw2	18	7	multiple	multiple	JJ
cord-314109-wb45naw2	18	8	systems	system	NNS
cord-314109-wb45naw2	18	9	throughout	throughout	IN
cord-314109-wb45naw2	18	10	the	the	DT
cord-314109-wb45naw2	18	11	body	body	NN
cord-314109-wb45naw2	18	12	in	in	IN
cord-314109-wb45naw2	18	13	both	both	DT
cord-314109-wb45naw2	18	14	birds	bird	NNS
cord-314109-wb45naw2	18	15	and	and	CC
cord-314109-wb45naw2	18	16	mammals	mammal	NNS
cord-314109-wb45naw2	18	17	.	.	.
cord-314109-wb45naw2	19	1	Coronaviruses	coronaviruse	NNS
cord-314109-wb45naw2	19	2	belong	belong	VBP
cord-314109-wb45naw2	19	3	to	to	IN
cord-314109-wb45naw2	19	4	the	the	DT
cord-314109-wb45naw2	19	5	family	family	NN
cord-314109-wb45naw2	19	6	of	of	IN
cord-314109-wb45naw2	19	7	Coronaviridae	Coronaviridae	NNP
cord-314109-wb45naw2	19	8	and	and	CC
cord-314109-wb45naw2	19	9	the	the	DT
cord-314109-wb45naw2	19	10	subfamily	subfamily	NN
cord-314109-wb45naw2	19	11	of	of	IN
cord-314109-wb45naw2	19	12	Orthocoronavirinae	Orthocoronavirinae	NNP
cord-314109-wb45naw2	19	13	.	.	.
cord-314109-wb45naw2	20	1	They	-PRON-	PRP
cord-314109-wb45naw2	20	2	are	be	VBP
cord-314109-wb45naw2	20	3	considered	consider	VBN
cord-314109-wb45naw2	20	4	to	to	TO
cord-314109-wb45naw2	20	5	be	be	VB
cord-314109-wb45naw2	20	6	large	large	JJ
cord-314109-wb45naw2	20	7	ribonucleic	ribonucleic	JJ
cord-314109-wb45naw2	20	8	acid	acid	NN
cord-314109-wb45naw2	20	9	(	(	-LRB-
cord-314109-wb45naw2	20	10	RNA	RNA	NNP
cord-314109-wb45naw2	20	11	)	)	-RRB-
cord-314109-wb45naw2	20	12	viruses	virus	NNS
cord-314109-wb45naw2	20	13	with	with	IN
cord-314109-wb45naw2	20	14	a	a	DT
cord-314109-wb45naw2	20	15	genome	genome	NN
cord-314109-wb45naw2	20	16	size	size	NN
cord-314109-wb45naw2	20	17	ranging	range	VBG
cord-314109-wb45naw2	20	18	from	from	IN
cord-314109-wb45naw2	20	19	26	26	CD
cord-314109-wb45naw2	20	20	to	to	TO
cord-314109-wb45naw2	20	21	32	32	CD
cord-314109-wb45naw2	20	22	kilobases	kilobase	NNS
cord-314109-wb45naw2	20	23	,	,	,
cord-314109-wb45naw2	20	24	are	be	VBP
cord-314109-wb45naw2	20	25	enveloped	envelop	VBN
cord-314109-wb45naw2	20	26	viruses	virus	NNS
cord-314109-wb45naw2	20	27	,	,	,
cord-314109-wb45naw2	20	28	single	single	JJ
cord-314109-wb45naw2	20	29	stranded	strand	VBN
cord-314109-wb45naw2	20	30	,	,	,
cord-314109-wb45naw2	20	31	and	and	CC
cord-314109-wb45naw2	20	32	have	have	VBP
cord-314109-wb45naw2	20	33	a	a	DT
cord-314109-wb45naw2	20	34	positive	positive	JJ
cord-314109-wb45naw2	20	35	-	-	HYPH
cord-314109-wb45naw2	20	36	sense	sense	NN
cord-314109-wb45naw2	20	37	single	single	NN
cord-314109-wb45naw2	20	38	stranded	strand	VBN
cord-314109-wb45naw2	20	39	RNA	RNA	NNP
cord-314109-wb45naw2	20	40	with	with	IN
cord-314109-wb45naw2	20	41	a	a	DT
cord-314109-wb45naw2	20	42	nucleocapsid	nucleocapsid	NN
cord-314109-wb45naw2	20	43	of	of	IN
cord-314109-wb45naw2	20	44	helical	helical	JJ
cord-314109-wb45naw2	20	45	symmetry	symmetry	NN
cord-314109-wb45naw2	20	46	.	.	.
cord-314109-wb45naw2	21	1	In	in	IN
cord-314109-wb45naw2	21	2	some	some	DT
cord-314109-wb45naw2	21	3	cases	case	NNS
cord-314109-wb45naw2	21	4	,	,	,
cord-314109-wb45naw2	21	5	coronaviruses	coronaviruse	NNS
cord-314109-wb45naw2	21	6	can	can	MD
cord-314109-wb45naw2	21	7	lead	lead	VB
cord-314109-wb45naw2	21	8	to	to	IN
cord-314109-wb45naw2	21	9	a	a	DT
cord-314109-wb45naw2	21	10	non	non	JJ
cord-314109-wb45naw2	21	11	-	-	JJ
cord-314109-wb45naw2	21	12	severe	severe	JJ
cord-314109-wb45naw2	21	13	illness	illness	NN
cord-314109-wb45naw2	21	14	with	with	IN
cord-314109-wb45naw2	21	15	symptoms	symptom	NNS
cord-314109-wb45naw2	21	16	similar	similar	JJ
cord-314109-wb45naw2	21	17	to	to	IN
cord-314109-wb45naw2	21	18	a	a	DT
cord-314109-wb45naw2	21	19	mild	mild	JJ
cord-314109-wb45naw2	21	20	upper	upper	JJ
cord-314109-wb45naw2	21	21	respiratory	respiratory	JJ
cord-314109-wb45naw2	21	22	illness	illness	NN
cord-314109-wb45naw2	21	23	.	.	.
cord-314109-wb45naw2	22	1	Yet	yet	RB
cord-314109-wb45naw2	22	2	,	,	,
cord-314109-wb45naw2	22	3	in	in	IN
cord-314109-wb45naw2	22	4	other	other	JJ
cord-314109-wb45naw2	22	5	cases	case	NNS
cord-314109-wb45naw2	22	6	,	,	,
cord-314109-wb45naw2	22	7	these	these	DT
cord-314109-wb45naw2	22	8	viruses	virus	NNS
cord-314109-wb45naw2	22	9	that	that	WDT
cord-314109-wb45naw2	22	10	include	include	VBP
cord-314109-wb45naw2	22	11	the	the	DT
cord-314109-wb45naw2	22	12	β	β	NN
cord-314109-wb45naw2	22	13	-	-	HYPH
cord-314109-wb45naw2	22	14	coronavirus	coronavirus	NN
cord-314109-wb45naw2	22	15	family	family	NN
cord-314109-wb45naw2	22	16	of	of	IN
cord-314109-wb45naw2	22	17	Severe	severe	JJ
cord-314109-wb45naw2	22	18	Acute	acute	JJ
cord-314109-wb45naw2	22	19	Respiratory	Respiratory	NNP
cord-314109-wb45naw2	22	20	Syndrome	Syndrome	NNP
cord-314109-wb45naw2	22	21	(	(	-LRB-
cord-314109-wb45naw2	22	22	SARS	SARS	NNP
cord-314109-wb45naw2	22	23	)	)	-RRB-
cord-314109-wb45naw2	22	24	virus	virus	NN
cord-314109-wb45naw2	22	25	,	,	,
cord-314109-wb45naw2	22	26	Middle	Middle	NNP
cord-314109-wb45naw2	22	27	East	East	NNP
cord-314109-wb45naw2	22	28	Respiratory	Respiratory	NNP
cord-314109-wb45naw2	22	29	Syndrome	Syndrome	NNP
cord-314109-wb45naw2	22	30	(	(	-LRB-
cord-314109-wb45naw2	22	31	MERS	MERS	NNP
cord-314109-wb45naw2	22	32	)	)	-RRB-
cord-314109-wb45naw2	22	33	virus	virus	NN
cord-314109-wb45naw2	22	34	,	,	,
cord-314109-wb45naw2	22	35	and	and	CC
cord-314109-wb45naw2	22	36	the	the	DT
cord-314109-wb45naw2	22	37	COVID-19	COVID-19	NNP
cord-314109-wb45naw2	22	38	(	(	-LRB-
cord-314109-wb45naw2	22	39	coronavirus	coronavirus	NN
cord-314109-wb45naw2	22	40	disease	disease	NN
cord-314109-wb45naw2	22	41	2019	2019	CD
cord-314109-wb45naw2	22	42	)	)	-RRB-
cord-314109-wb45naw2	23	1	causative	causative	JJ
cord-314109-wb45naw2	23	2	agent	agent	NN
cord-314109-wb45naw2	23	3	SARS	SARS	NNP
cord-314109-wb45naw2	23	4	-	-	HYPH
cord-314109-wb45naw2	23	5	CoV-2	CoV-2	NNP
cord-314109-wb45naw2	23	6	can	can	MD
cord-314109-wb45naw2	23	7	result	result	VB
cord-314109-wb45naw2	23	8	in	in	IN
cord-314109-wb45naw2	23	9	severe	severe	JJ
cord-314109-wb45naw2	23	10	upper	upper	JJ
cord-314109-wb45naw2	23	11	respiratory	respiratory	JJ
cord-314109-wb45naw2	23	12	tract	tract	NN
cord-314109-wb45naw2	23	13	disease	disease	NN
cord-314109-wb45naw2	23	14	[	[	-LRB-
cord-314109-wb45naw2	23	15	1	1	CD
cord-314109-wb45naw2	23	16	]	]	-RRB-
cord-314109-wb45naw2	23	17	.	.	.
cord-314109-wb45naw2	24	1	In	in	IN
cord-314109-wb45naw2	24	2	regards	regard	NNS
cord-314109-wb45naw2	24	3	to	to	IN
cord-314109-wb45naw2	24	4	the	the	DT
cord-314109-wb45naw2	24	5	disease	disease	NN
cord-314109-wb45naw2	24	6	of	of	IN
cord-314109-wb45naw2	24	7	COVID-19	COVID-19	NNP
cord-314109-wb45naw2	24	8	,	,	,
cord-314109-wb45naw2	24	9	the	the	DT
cord-314109-wb45naw2	24	10	SARS	SARS	NNP
cord-314109-wb45naw2	24	11	-	-	HYPH
cord-314109-wb45naw2	24	12	CoV-2	CoV-2	NNP
cord-314109-wb45naw2	24	13	virus	virus	NN
cord-314109-wb45naw2	24	14	was	be	VBD
cord-314109-wb45naw2	24	15	reported	report	VBN
cord-314109-wb45naw2	24	16	in	in	IN
cord-314109-wb45naw2	24	17	December	December	NNP
cord-314109-wb45naw2	24	18	of	of	IN
cord-314109-wb45naw2	24	19	2019	2019	CD
cord-314109-wb45naw2	24	20	in	in	IN
cord-314109-wb45naw2	24	21	Wuhan	Wuhan	NNP
cord-314109-wb45naw2	24	22	,	,	,
cord-314109-wb45naw2	24	23	China	China	NNP
cord-314109-wb45naw2	24	24	and	and	CC
cord-314109-wb45naw2	24	25	spread	spread	VBD
cord-314109-wb45naw2	24	26	in	in	IN
cord-314109-wb45naw2	24	27	the	the	DT
cord-314109-wb45naw2	24	28	population	population	NN
cord-314109-wb45naw2	24	29	leading	lead	VBG
cord-314109-wb45naw2	24	30	to	to	IN
cord-314109-wb45naw2	24	31	individuals	individual	NNS
cord-314109-wb45naw2	24	32	experiencing	experience	VBG
cord-314109-wb45naw2	24	33	symptoms	symptom	NNS
cord-314109-wb45naw2	24	34	of	of	IN
cord-314109-wb45naw2	24	35	fever	fever	NN
cord-314109-wb45naw2	24	36	,	,	,
cord-314109-wb45naw2	24	37	cough	cough	NN
cord-314109-wb45naw2	24	38	,	,	,
cord-314109-wb45naw2	24	39	gastrointestinal	gastrointestinal	JJ
cord-314109-wb45naw2	24	40	disturbances	disturbance	NNS
cord-314109-wb45naw2	24	41	,	,	,
cord-314109-wb45naw2	24	42	and	and	CC
cord-314109-wb45naw2	24	43	respiratory	respiratory	JJ
cord-314109-wb45naw2	24	44	dysfunction	dysfunction	NN
cord-314109-wb45naw2	24	45	[	[	-LRB-
cord-314109-wb45naw2	24	46	2	2	CD
cord-314109-wb45naw2	24	47	]	]	-RRB-
cord-314109-wb45naw2	24	48	.	.	.
cord-314109-wb45naw2	25	1	The	the	DT
cord-314109-wb45naw2	25	2	virus	virus	NN
cord-314109-wb45naw2	25	3	has	have	VBZ
cord-314109-wb45naw2	25	4	travelled	travel	VBN
cord-314109-wb45naw2	25	5	globally	globally	RB
cord-314109-wb45naw2	25	6	with	with	IN
cord-314109-wb45naw2	25	7	the	the	DT
cord-314109-wb45naw2	25	8	World	World	NNP
cord-314109-wb45naw2	25	9	Health	Health	NNP
cord-314109-wb45naw2	25	10	Organization	Organization	NNP
cord-314109-wb45naw2	25	11	(	(	-LRB-
cord-314109-wb45naw2	25	12	WHO	who	WP
cord-314109-wb45naw2	25	13	)	)	-RRB-
cord-314109-wb45naw2	25	14	declaring	declare	VBG
cord-314109-wb45naw2	25	15	COVID-19	COVID-19	,
cord-314109-wb45naw2	25	16	a	a	DT
cord-314109-wb45naw2	25	17	Public	Public	NNP
cord-314109-wb45naw2	25	18	Health	Health	NNP
cord-314109-wb45naw2	25	19	Emergency	Emergency	NNP
cord-314109-wb45naw2	25	20	of	of	IN
cord-314109-wb45naw2	25	21	International	International	NNP
cord-314109-wb45naw2	25	22	Concern	Concern	NNP
cord-314109-wb45naw2	25	23	,	,	,
cord-314109-wb45naw2	25	24	a	a	DT
cord-314109-wb45naw2	25	25	pandemic	pandemic	NN
cord-314109-wb45naw2	25	26	,	,	,
cord-314109-wb45naw2	25	27	and	and	CC
cord-314109-wb45naw2	25	28	releasing	release	VBG
cord-314109-wb45naw2	25	29	on	on	IN
cord-314109-wb45naw2	25	30	-	-	HYPH
cord-314109-wb45naw2	25	31	going	go	VBG
cord-314109-wb45naw2	25	32	guidelines	guideline	NNS
cord-314109-wb45naw2	25	33	to	to	TO
cord-314109-wb45naw2	25	34	prevent	prevent	VB
cord-314109-wb45naw2	25	35	transmission	transmission	NN
cord-314109-wb45naw2	25	36	of	of	IN
cord-314109-wb45naw2	25	37	the	the	DT
cord-314109-wb45naw2	25	38	virus	virus	NN
cord-314109-wb45naw2	25	39	[	[	-LRB-
cord-314109-wb45naw2	25	40	3	3	CD
cord-314109-wb45naw2	25	41	]	]	-RRB-
cord-314109-wb45naw2	25	42	.	.	.
cord-314109-wb45naw2	26	1	To	to	IN
cord-314109-wb45naw2	26	2	date	date	NN
cord-314109-wb45naw2	26	3	,	,	,
cord-314109-wb45naw2	26	4	SARS	SARS	NNP
cord-314109-wb45naw2	26	5	-	-	HYPH
cord-314109-wb45naw2	26	6	CoV-2	CoV-2	NNP
cord-314109-wb45naw2	26	7	has	have	VBZ
cord-314109-wb45naw2	26	8	infected	infect	VBN
cord-314109-wb45naw2	26	9	over	over	IN
cord-314109-wb45naw2	26	10	two	two	CD
cord-314109-wb45naw2	26	11	million	million	CD
cord-314109-wb45naw2	26	12	individuals	individual	NNS
cord-314109-wb45naw2	26	13	worldwide	worldwide	RB
cord-314109-wb45naw2	26	14	with	with	IN
cord-314109-wb45naw2	26	15	the	the	DT
cord-314109-wb45naw2	26	16	majority	majority	NN
cord-314109-wb45naw2	26	17	of	of	IN
cord-314109-wb45naw2	26	18	those	those	DT
cord-314109-wb45naw2	26	19	infected	infect	VBN
cord-314109-wb45naw2	26	20	experiencing	experience	VBG
cord-314109-wb45naw2	26	21	mild	mild	JJ
cord-314109-wb45naw2	26	22	symptoms	symptom	NNS
cord-314109-wb45naw2	26	23	and	and	CC
cord-314109-wb45naw2	26	24	recovering	recover	VBG
cord-314109-wb45naw2	26	25	usually	usually	RB
cord-314109-wb45naw2	26	26	in	in	IN
cord-314109-wb45naw2	26	27	fourteen	fourteen	CD
cord-314109-wb45naw2	26	28	-	-	HYPH
cord-314109-wb45naw2	26	29	day	day	NN
cord-314109-wb45naw2	26	30	period	period	NN
cord-314109-wb45naw2	26	31	after	after	IN
cord-314109-wb45naw2	26	32	symptom	symptom	NN
cord-314109-wb45naw2	26	33	onset	onset	NN
cord-314109-wb45naw2	26	34	.	.	.
cord-314109-wb45naw2	27	1	Yet	yet	RB
cord-314109-wb45naw2	27	2	,	,	,
cord-314109-wb45naw2	27	3	a	a	DT
cord-314109-wb45naw2	27	4	smaller	small	JJR
cord-314109-wb45naw2	27	5	percentage	percentage	NN
cord-314109-wb45naw2	27	6	of	of	IN
cord-314109-wb45naw2	27	7	individuals	individual	NNS
cord-314109-wb45naw2	27	8	can	can	MD
cord-314109-wb45naw2	27	9	become	become	VB
cord-314109-wb45naw2	27	10	critically	critically	RB
cord-314109-wb45naw2	27	11	ill	ill	JJ
cord-314109-wb45naw2	27	12	with	with	IN
cord-314109-wb45naw2	27	13	multi	multi	JJ
cord-314109-wb45naw2	27	14	-	-	JJ
cord-314109-wb45naw2	27	15	system	system	JJ
cord-314109-wb45naw2	27	16	illness	illness	NN
cord-314109-wb45naw2	27	17	and	and	CC
cord-314109-wb45naw2	27	18	respiratory	respiratory	JJ
cord-314109-wb45naw2	27	19	disease	disease	NN
cord-314109-wb45naw2	27	20	progressing	progress	VBG
cord-314109-wb45naw2	27	21	to	to	IN
cord-314109-wb45naw2	27	22	acute	acute	JJ
cord-314109-wb45naw2	27	23	respiratory	respiratory	JJ
cord-314109-wb45naw2	27	24	distress	distress	NN
cord-314109-wb45naw2	27	25	syndrome	syndrome	NN
cord-314109-wb45naw2	27	26	.	.	.
cord-314109-wb45naw2	28	1	Given	give	VBN
cord-314109-wb45naw2	28	2	the	the	DT
cord-314109-wb45naw2	28	3	global	global	JJ
cord-314109-wb45naw2	28	4	scope	scope	NN
cord-314109-wb45naw2	28	5	of	of	IN
cord-314109-wb45naw2	28	6	COVID-19	COVID-19	NNP
cord-314109-wb45naw2	28	7	,	,	,
cord-314109-wb45naw2	28	8	this	this	DT
cord-314109-wb45naw2	28	9	smaller	small	JJR
cord-314109-wb45naw2	28	10	percentage	percentage	NN
cord-314109-wb45naw2	28	11	of	of	IN
cord-314109-wb45naw2	28	12	individuals	individual	NNS
cord-314109-wb45naw2	28	13	who	who	WP
cord-314109-wb45naw2	28	14	are	be	VBP
cord-314109-wb45naw2	28	15	afflicted	afflict	VBN
cord-314109-wb45naw2	28	16	with	with	IN
cord-314109-wb45naw2	28	17	debilitating	debilitating	JJ
cord-314109-wb45naw2	28	18	disease	disease	NN
cord-314109-wb45naw2	28	19	can	can	MD
cord-314109-wb45naw2	28	20	affect	affect	VB
cord-314109-wb45naw2	28	21	both	both	DT
cord-314109-wb45naw2	28	22	young	young	JJ
cord-314109-wb45naw2	28	23	individuals	individual	NNS
cord-314109-wb45naw2	28	24	as	as	RB
cord-314109-wb45naw2	28	25	well	well	RB
cord-314109-wb45naw2	28	26	as	as	IN
cord-314109-wb45naw2	28	27	older	old	JJR
cord-314109-wb45naw2	28	28	individuals	individual	NNS
cord-314109-wb45naw2	28	29	[	[	-LRB-
cord-314109-wb45naw2	28	30	1	1	CD
cord-314109-wb45naw2	28	31	]	]	-RRB-
cord-314109-wb45naw2	28	32	.	.	.
cord-314109-wb45naw2	29	1	In	in	IN
cord-314109-wb45naw2	29	2	addition	addition	NN
cord-314109-wb45naw2	29	3	,	,	,
cord-314109-wb45naw2	29	4	with	with	IN
cord-314109-wb45naw2	29	5	efforts	effort	NNS
cord-314109-wb45naw2	29	6	to	to	TO
cord-314109-wb45naw2	29	7	markedly	markedly	RB
cord-314109-wb45naw2	29	8	reduce	reduce	VB
cord-314109-wb45naw2	29	9	transmission	transmission	NN
cord-314109-wb45naw2	29	10	rates	rate	NNS
cord-314109-wb45naw2	29	11	,	,	,
cord-314109-wb45naw2	29	12	global	global	JJ
cord-314109-wb45naw2	29	13	economies	economy	NNS
cord-314109-wb45naw2	29	14	have	have	VBP
cord-314109-wb45naw2	29	15	become	become	VBN
cord-314109-wb45naw2	29	16	challenged	challenge	VBN
cord-314109-wb45naw2	29	17	,	,	,
cord-314109-wb45naw2	29	18	physical	physical	JJ
cord-314109-wb45naw2	29	19	and	and	CC
cord-314109-wb45naw2	29	20	behavior	behavior	NN
cord-314109-wb45naw2	29	21	health	health	NN
cord-314109-wb45naw2	29	22	issues	issue	NNS
cord-314109-wb45naw2	29	23	have	have	VBP
cord-314109-wb45naw2	29	24	arisen	arise	VBN
cord-314109-wb45naw2	29	25	,	,	,
cord-314109-wb45naw2	29	26	and	and	CC
cord-314109-wb45naw2	29	27	educational	educational	JJ
cord-314109-wb45naw2	29	28	hurdles	hurdle	NNS
cord-314109-wb45naw2	29	29	with	with	IN
cord-314109-wb45naw2	29	30	school	school	NN
cord-314109-wb45naw2	29	31	closures	closure	NNS
cord-314109-wb45naw2	29	32	have	have	VBP
cord-314109-wb45naw2	29	33	developed	develop	VBN
cord-314109-wb45naw2	29	34	[	[	-LRB-
cord-314109-wb45naw2	29	35	4	4	CD
cord-314109-wb45naw2	29	36	]	]	-RRB-
cord-314109-wb45naw2	29	37	.	.	.
cord-314109-wb45naw2	30	1	As	as	IN
cord-314109-wb45naw2	30	2	an	an	DT
cord-314109-wb45naw2	30	3	infectious	infectious	JJ
cord-314109-wb45naw2	30	4	virion	virion	NN
cord-314109-wb45naw2	30	5	to	to	IN
cord-314109-wb45naw2	30	6	humans	human	NNS
cord-314109-wb45naw2	30	7	,	,	,
cord-314109-wb45naw2	30	8	SARS	SARS	NNP
cord-314109-wb45naw2	30	9	-	-	HYPH
cord-314109-wb45naw2	30	10	CoV-2	CoV-2	NNP
cord-314109-wb45naw2	30	11	relies	rely	VBZ
cord-314109-wb45naw2	30	12	upon	upon	IN
cord-314109-wb45naw2	30	13	highly	highly	RB
cord-314109-wb45naw2	30	14	targeted	target	VBN
cord-314109-wb45naw2	30	15	binding	binding	NN
cord-314109-wb45naw2	30	16	to	to	IN
cord-314109-wb45naw2	30	17	host	host	NN
cord-314109-wb45naw2	30	18	cells	cell	NNS
cord-314109-wb45naw2	30	19	,	,	,
cord-314109-wb45naw2	30	20	such	such	JJ
cord-314109-wb45naw2	30	21	as	as	IN
cord-314109-wb45naw2	30	22	in	in	IN
cord-314109-wb45naw2	30	23	the	the	DT
cord-314109-wb45naw2	30	24	nasal	nasal	JJ
cord-314109-wb45naw2	30	25	epithelial	epithelial	JJ
cord-314109-wb45naw2	30	26	region	region	NN
cord-314109-wb45naw2	30	27	[	[	-LRB-
cord-314109-wb45naw2	30	28	5	5	CD
cord-314109-wb45naw2	30	29	]	]	-RRB-
cord-314109-wb45naw2	30	30	,	,	,
cord-314109-wb45naw2	30	31	as	as	RB
cord-314109-wb45naw2	30	32	well	well	RB
cord-314109-wb45naw2	30	33	as	as	IN
cord-314109-wb45naw2	30	34	an	an	DT
cord-314109-wb45naw2	30	35	excessive	excessive	JJ
cord-314109-wb45naw2	30	36	and	and	CC
cord-314109-wb45naw2	30	37	exaggerated	exaggerated	JJ
cord-314109-wb45naw2	30	38	activation	activation	NN
cord-314109-wb45naw2	30	39	of	of	IN
cord-314109-wb45naw2	30	40	the	the	DT
cord-314109-wb45naw2	30	41	host	host	NN
cord-314109-wb45naw2	30	42	's	's	POS
cord-314109-wb45naw2	30	43	immune	immune	JJ
cord-314109-wb45naw2	30	44	system	system	NN
cord-314109-wb45naw2	30	45	[	[	-LRB-
cord-314109-wb45naw2	30	46	6	6	CD
cord-314109-wb45naw2	30	47	]	]	-RRB-
cord-314109-wb45naw2	30	48	.	.	.
cord-314109-wb45naw2	31	1	The	the	DT
cord-314109-wb45naw2	31	2	viral	viral	JJ
cord-314109-wb45naw2	31	3	S	s	NN
cord-314109-wb45naw2	31	4	protein	protein	NN
cord-314109-wb45naw2	31	5	allows	allow	VBZ
cord-314109-wb45naw2	31	6	SARS	SARS	NNP
cord-314109-wb45naw2	31	7	-	-	HYPH
cord-314109-wb45naw2	31	8	CoV-2	CoV-2	NNP
cord-314109-wb45naw2	31	9	to	to	TO
cord-314109-wb45naw2	31	10	access	access	VB
cord-314109-wb45naw2	31	11	host	host	NN
cord-314109-wb45naw2	31	12	cells	cell	NNS
cord-314109-wb45naw2	31	13	through	through	IN
cord-314109-wb45naw2	31	14	the	the	DT
cord-314109-wb45naw2	31	15	angiotensin	angiotensin	NN
cord-314109-wb45naw2	31	16	converting	convert	VBG
cord-314109-wb45naw2	31	17	enzyme	enzyme	NN
cord-314109-wb45naw2	31	18	2	2	CD
cord-314109-wb45naw2	31	19	(	(	-LRB-
cord-314109-wb45naw2	31	20	ACE2	ACE2	NNP
cord-314109-wb45naw2	31	21	)	)	-RRB-
cord-314109-wb45naw2	31	22	receptor	receptor	NN
cord-314109-wb45naw2	31	23	that	that	WDT
cord-314109-wb45naw2	31	24	is	be	VBZ
cord-314109-wb45naw2	31	25	expressed	express	VBN
cord-314109-wb45naw2	31	26	in	in	IN
cord-314109-wb45naw2	31	27	pulmonary	pulmonary	JJ
cord-314109-wb45naw2	31	28	,	,	,
cord-314109-wb45naw2	31	29	renal	renal	JJ
cord-314109-wb45naw2	31	30	,	,	,
cord-314109-wb45naw2	31	31	cardiac	cardiac	JJ
cord-314109-wb45naw2	31	32	,	,	,
cord-314109-wb45naw2	31	33	vascular	vascular	JJ
cord-314109-wb45naw2	31	34	,	,	,
cord-314109-wb45naw2	31	35	and	and	CC
cord-314109-wb45naw2	31	36	gastrointestinal	gastrointestinal	JJ
cord-314109-wb45naw2	31	37	cells	cell	NNS
cord-314109-wb45naw2	31	38	[	[	-LRB-
cord-314109-wb45naw2	31	39	1	1	CD
cord-314109-wb45naw2	31	40	]	]	-RRB-
cord-314109-wb45naw2	31	41	.	.	.
cord-314109-wb45naw2	32	1	During	during	IN
cord-314109-wb45naw2	32	2	this	this	DT
cord-314109-wb45naw2	32	3	process	process	NN
cord-314109-wb45naw2	32	4	,	,	,
cord-314109-wb45naw2	32	5	the	the	DT
cord-314109-wb45naw2	32	6	S	S	NNP
cord-314109-wb45naw2	32	7	protein	protein	NN
cord-314109-wb45naw2	32	8	is	be	VBZ
cord-314109-wb45naw2	32	9	cleaved	cleave	VBN
cord-314109-wb45naw2	32	10	into	into	IN
cord-314109-wb45naw2	32	11	S1	S1	NNP
cord-314109-wb45naw2	32	12	and	and	CC
cord-314109-wb45naw2	32	13	S2	S2	NNP
cord-314109-wb45naw2	32	14	with	with	IN
cord-314109-wb45naw2	32	15	S1	s1	NN
cord-314109-wb45naw2	32	16	binding	bind	VBG
cord-314109-wb45naw2	32	17	to	to	IN
cord-314109-wb45naw2	32	18	ACE2	ACE2	NNP
cord-314109-wb45naw2	32	19	and	and	CC
cord-314109-wb45naw2	32	20	S2	S2	NNP
cord-314109-wb45naw2	32	21	activated	activate	VBN
cord-314109-wb45naw2	32	22	by	by	IN
cord-314109-wb45naw2	32	23	the	the	DT
cord-314109-wb45naw2	32	24	host	host	NN
cord-314109-wb45naw2	32	25	surface	surface	NN
cord-314109-wb45naw2	32	26	-	-	HYPH
cord-314109-wb45naw2	32	27	associated	associate	VBN
cord-314109-wb45naw2	32	28	transmembrane	transmembrane	NN
cord-314109-wb45naw2	32	29	protease	protease	NN
cord-314109-wb45naw2	32	30	serine	serine	NN
cord-314109-wb45naw2	32	31	2	2	CD
cord-314109-wb45naw2	32	32	(	(	-LRB-
cord-314109-wb45naw2	32	33	TMPRSS2	TMPRSS2	NNP
cord-314109-wb45naw2	32	34	)	)	-RRB-
cord-314109-wb45naw2	32	35	to	to	TO
cord-314109-wb45naw2	32	36	allow	allow	VB
cord-314109-wb45naw2	32	37	the	the	DT
cord-314109-wb45naw2	32	38	virus	virus	NN
cord-314109-wb45naw2	32	39	to	to	TO
cord-314109-wb45naw2	32	40	fuse	fuse	VB
cord-314109-wb45naw2	32	41	with	with	IN
cord-314109-wb45naw2	32	42	the	the	DT
cord-314109-wb45naw2	32	43	host	host	NN
cord-314109-wb45naw2	32	44	cell	cell	NN
cord-314109-wb45naw2	32	45	membrane	membrane	NN
cord-314109-wb45naw2	32	46	and	and	CC
cord-314109-wb45naw2	32	47	become	become	VB
cord-314109-wb45naw2	32	48	endocytosed	endocytose	VBN
cord-314109-wb45naw2	32	49	by	by	IN
cord-314109-wb45naw2	32	50	the	the	DT
cord-314109-wb45naw2	32	51	host	host	NN
cord-314109-wb45naw2	32	52	cell	cell	NN
cord-314109-wb45naw2	32	53	.	.	.
cord-314109-wb45naw2	33	1	Using	use	VBG
cord-314109-wb45naw2	33	2	the	the	DT
cord-314109-wb45naw2	33	3	host	host	NN
cord-314109-wb45naw2	33	4	cell	cell	NN
cord-314109-wb45naw2	33	5	's	's	POS
cord-314109-wb45naw2	33	6	organelles	organelle	NNS
cord-314109-wb45naw2	33	7	,	,	,
cord-314109-wb45naw2	33	8	new	new	JJ
cord-314109-wb45naw2	33	9	viral	viral	JJ
cord-314109-wb45naw2	33	10	RNA	RNA	NNP
cord-314109-wb45naw2	33	11	is	be	VBZ
cord-314109-wb45naw2	33	12	translated	translate	VBN
cord-314109-wb45naw2	33	13	with	with	IN
cord-314109-wb45naw2	33	14	necessary	necessary	JJ
cord-314109-wb45naw2	33	15	structural	structural	JJ
cord-314109-wb45naw2	33	16	proteins	protein	NNS
cord-314109-wb45naw2	33	17	to	to	TO
cord-314109-wb45naw2	33	18	ultimately	ultimately	RB
cord-314109-wb45naw2	33	19	assemble	assemble	VB
cord-314109-wb45naw2	33	20	new	new	JJ
cord-314109-wb45naw2	33	21	SARS	SARS	NNP
cord-314109-wb45naw2	33	22	-	-	HYPH
cord-314109-wb45naw2	33	23	CoV-2	CoV-2	NNP
cord-314109-wb45naw2	33	24	virions	virion	NNS
cord-314109-wb45naw2	33	25	and	and	CC
cord-314109-wb45naw2	33	26	infect	infect	VB
cord-314109-wb45naw2	33	27	new	new	JJ
cord-314109-wb45naw2	33	28	cells	cell	NNS
cord-314109-wb45naw2	33	29	.	.	.
cord-314109-wb45naw2	34	1	In	in	IN
cord-314109-wb45naw2	34	2	this	this	DT
cord-314109-wb45naw2	34	3	process	process	NN
cord-314109-wb45naw2	34	4	,	,	,
cord-314109-wb45naw2	34	5	systemic	systemic	JJ
cord-314109-wb45naw2	34	6	hyperinflammation	hyperinflammation	NN
cord-314109-wb45naw2	34	7	can	can	MD
cord-314109-wb45naw2	34	8	occur	occur	VB
cord-314109-wb45naw2	34	9	with	with	IN
cord-314109-wb45naw2	34	10	the	the	DT
cord-314109-wb45naw2	34	11	activation	activation	NN
cord-314109-wb45naw2	34	12	and	and	CC
cord-314109-wb45naw2	34	13	elevation	elevation	NN
cord-314109-wb45naw2	34	14	of	of	IN
cord-314109-wb45naw2	34	15	multiple	multiple	JJ
cord-314109-wb45naw2	34	16	pro	pro	JJ
cord-314109-wb45naw2	34	17	-	-	JJ
cord-314109-wb45naw2	34	18	inflammatory	inflammatory	JJ
cord-314109-wb45naw2	34	19	cytokines	cytokine	NNS
cord-314109-wb45naw2	34	20	,	,	,
cord-314109-wb45naw2	34	21	tumor	tumor	NN
cord-314109-wb45naw2	34	22	necrosis	necrosis	NN
cord-314109-wb45naw2	34	23	factor	factor	NN
cord-314109-wb45naw2	34	24	-	-	HYPH
cord-314109-wb45naw2	34	25	α	α	NN
cord-314109-wb45naw2	34	26	(	(	-LRB-
cord-314109-wb45naw2	34	27	TNF	TNF	NNP
cord-314109-wb45naw2	34	28	-	-	HYPH
cord-314109-wb45naw2	34	29	α	α	NNP
cord-314109-wb45naw2	34	30	)	)	-RRB-
cord-314109-wb45naw2	34	31	,	,	,
cord-314109-wb45naw2	34	32	interleukins	interleukin	NNS
cord-314109-wb45naw2	34	33	,	,	,
cord-314109-wb45naw2	34	34	interferons	interferon	NNS
cord-314109-wb45naw2	34	35	,	,	,
cord-314109-wb45naw2	34	36	monocyte	monocyte	NNP
cord-314109-wb45naw2	34	37	chemoattractant	chemoattractant	NNP
cord-314109-wb45naw2	34	38	protein	protein	NNP
cord-314109-wb45naw2	34	39	1	1	CD
cord-314109-wb45naw2	34	40	(	(	-LRB-
cord-314109-wb45naw2	34	41	MCP-1	MCP-1	NNP
cord-314109-wb45naw2	34	42	)	)	-RRB-
cord-314109-wb45naw2	34	43	,	,	,
cord-314109-wb45naw2	34	44	and	and	CC
cord-314109-wb45naw2	34	45	macrophage	macrophage	NN
cord-314109-wb45naw2	34	46	inflammatory	inflammatory	JJ
cord-314109-wb45naw2	34	47	protein	protein	NN
cord-314109-wb45naw2	34	48	1-α	1-α	CD
cord-314109-wb45naw2	34	49	(	(	-LRB-
cord-314109-wb45naw2	34	50	MIP-1α	MIP-1α	NNP
cord-314109-wb45naw2	34	51	)	)	-RRB-
cord-314109-wb45naw2	34	52	[	[	-LRB-
cord-314109-wb45naw2	34	53	7	7	CD
cord-314109-wb45naw2	34	54	]	]	-RRB-
cord-314109-wb45naw2	34	55	.	.	.
cord-314109-wb45naw2	35	1	Interestingly	interestingly	RB
cord-314109-wb45naw2	35	2	,	,	,
cord-314109-wb45naw2	35	3	those	those	DT
cord-314109-wb45naw2	35	4	individuals	individual	NNS
cord-314109-wb45naw2	35	5	with	with	IN
cord-314109-wb45naw2	35	6	significant	significant	JJ
cord-314109-wb45naw2	35	7	co	co	NNS
cord-314109-wb45naw2	35	8	-	-	NNS
cord-314109-wb45naw2	35	9	morbidities	morbidity	NNS
cord-314109-wb45naw2	35	10	such	such	JJ
cord-314109-wb45naw2	35	11	as	as	IN
cord-314109-wb45naw2	35	12	diabetes	diabetes	NN
cord-314109-wb45naw2	35	13	mellitus	mellitus	NN
cord-314109-wb45naw2	35	14	(	(	-LRB-
cord-314109-wb45naw2	35	15	DM	DM	NNP
cord-314109-wb45naw2	35	16	)	)	-RRB-
cord-314109-wb45naw2	35	17	appear	appear	VBP
cord-314109-wb45naw2	35	18	to	to	TO
cord-314109-wb45naw2	35	19	have	have	VB
cord-314109-wb45naw2	35	20	increased	increase	VBN
cord-314109-wb45naw2	35	21	risk	risk	NN
cord-314109-wb45naw2	35	22	for	for	IN
cord-314109-wb45naw2	35	23	developing	develop	VBG
cord-314109-wb45naw2	35	24	significant	significant	JJ
cord-314109-wb45naw2	35	25	illness	illness	NN
cord-314109-wb45naw2	35	26	with	with	IN
cord-314109-wb45naw2	35	27	COVID-19	COVID-19	NNP
cord-314109-wb45naw2	35	28	[	[	-LRB-
cord-314109-wb45naw2	35	29	8	8	CD
cord-314109-wb45naw2	35	30	]	]	-RRB-
cord-314109-wb45naw2	35	31	.	.	.
cord-314109-wb45naw2	36	1	Currently	currently	RB
cord-314109-wb45naw2	36	2	,	,	,
cord-314109-wb45naw2	36	3	multiple	multiple	JJ
cord-314109-wb45naw2	36	4	resources	resource	NNS
cord-314109-wb45naw2	36	5	are	be	VBP
cord-314109-wb45naw2	36	6	aggressively	aggressively	RB
cord-314109-wb45naw2	36	7	being	be	VBG
cord-314109-wb45naw2	36	8	deployed	deploy	VBN
cord-314109-wb45naw2	36	9	to	to	TO
cord-314109-wb45naw2	36	10	develop	develop	VB
cord-314109-wb45naw2	36	11	treatments	treatment	NNS
cord-314109-wb45naw2	36	12	[	[	-LRB-
cord-314109-wb45naw2	36	13	9	9	CD
cord-314109-wb45naw2	36	14	]	]	-RRB-
cord-314109-wb45naw2	36	15	and	and	CC
cord-314109-wb45naw2	36	16	potential	potential	JJ
cord-314109-wb45naw2	36	17	vaccines	vaccine	NNS
cord-314109-wb45naw2	36	18	for	for	IN
cord-314109-wb45naw2	36	19	COVID-19	COVID-19	NNP
cord-314109-wb45naw2	36	20	[	[	-LRB-
cord-314109-wb45naw2	36	21	10	10	CD
cord-314109-wb45naw2	36	22	]	]	-RRB-
cord-314109-wb45naw2	36	23	.	.	.
cord-314109-wb45naw2	37	1	Since	since	IN
cord-314109-wb45naw2	37	2	therapeutic	therapeutic	JJ
cord-314109-wb45naw2	37	3	strategies	strategy	NNS
cord-314109-wb45naw2	37	4	are	be	VBP
cord-314109-wb45naw2	37	5	mostly	mostly	RB
cord-314109-wb45naw2	37	6	symptomatic	symptomatic	JJ
cord-314109-wb45naw2	37	7	at	at	IN
cord-314109-wb45naw2	37	8	present	present	NN
cord-314109-wb45naw2	37	9	for	for	IN
cord-314109-wb45naw2	37	10	COVID-19	COVID-19	NNP
cord-314109-wb45naw2	37	11	,	,	,
cord-314109-wb45naw2	37	12	therapies	therapy	NNS
cord-314109-wb45naw2	37	13	that	that	WDT
cord-314109-wb45naw2	37	14	can	can	MD
cord-314109-wb45naw2	37	15	repurpose	repurpose	VB
cord-314109-wb45naw2	37	16	existing	exist	VBG
cord-314109-wb45naw2	37	17	clinically	clinically	RB
cord-314109-wb45naw2	37	18	approved	approve	VBN
cord-314109-wb45naw2	37	19	antiviral	antiviral	JJ
cord-314109-wb45naw2	37	20	drugs	drug	NNS
cord-314109-wb45naw2	37	21	are	be	VBP
cord-314109-wb45naw2	37	22	being	be	VBG
cord-314109-wb45naw2	37	23	considered	consider	VBN
cord-314109-wb45naw2	37	24	[	[	-LRB-
cord-314109-wb45naw2	37	25	11	11	CD
cord-314109-wb45naw2	37	26	]	]	-RRB-
cord-314109-wb45naw2	37	27	.	.	.
cord-314109-wb45naw2	38	1	Other	other	JJ
cord-314109-wb45naw2	38	2	strategies	strategy	NNS
cord-314109-wb45naw2	38	3	can	can	MD
cord-314109-wb45naw2	38	4	include	include	VB
cord-314109-wb45naw2	38	5	the	the	DT
cord-314109-wb45naw2	38	6	examination	examination	NN
cord-314109-wb45naw2	38	7	of	of	IN
cord-314109-wb45naw2	38	8	novel	novel	JJ
cord-314109-wb45naw2	38	9	pathways	pathway	NNS
cord-314109-wb45naw2	38	10	not	not	RB
cord-314109-wb45naw2	38	11	normally	normally	RB
cord-314109-wb45naw2	38	12	considered	consider	VBN
cord-314109-wb45naw2	38	13	to	to	TO
cord-314109-wb45naw2	38	14	have	have	VB
cord-314109-wb45naw2	38	15	antiviral	antiviral	JJ
cord-314109-wb45naw2	38	16	treatment	treatment	NN
cord-314109-wb45naw2	38	17	capabilities	capability	NNS
cord-314109-wb45naw2	38	18	.	.	.
cord-314109-wb45naw2	39	1	One	one	CD
cord-314109-wb45naw2	39	2	such	such	JJ
cord-314109-wb45naw2	39	3	pathway	pathway	NN
cord-314109-wb45naw2	39	4	involves	involve	VBZ
cord-314109-wb45naw2	39	5	the	the	DT
cord-314109-wb45naw2	39	6	mechanistic	mechanistic	JJ
cord-314109-wb45naw2	39	7	target	target	NN
cord-314109-wb45naw2	39	8	of	of	IN
cord-314109-wb45naw2	39	9	rapamycin	rapamycin	NNP
cord-314109-wb45naw2	39	10	(	(	-LRB-
cord-314109-wb45naw2	39	11	mTOR	mTOR	NNP
cord-314109-wb45naw2	39	12	)	)	-RRB-
cord-314109-wb45naw2	39	13	and	and	CC
cord-314109-wb45naw2	39	14	its	-PRON-	PRP$
cord-314109-wb45naw2	39	15	associated	associate	VBN
cord-314109-wb45naw2	39	16	pathways	pathway	NNS
cord-314109-wb45naw2	39	17	with	with	IN
cord-314109-wb45naw2	39	18	mTOR	mTOR	NNP
cord-314109-wb45naw2	39	19	Complex	Complex	NNP
cord-314109-wb45naw2	39	20	1	1	CD
cord-314109-wb45naw2	39	21	(	(	-LRB-
cord-314109-wb45naw2	39	22	mTORC1	mTORC1	NNP
cord-314109-wb45naw2	39	23	)	)	-RRB-
cord-314109-wb45naw2	39	24	,	,	.
cord-314109-wb45naw2	40	1	mTOR	mTOR	NNP
cord-314109-wb45naw2	40	2	Complex	Complex	NNP
cord-314109-wb45naw2	40	3	2	2	CD
cord-314109-wb45naw2	40	4	(	(	-LRB-
cord-314109-wb45naw2	40	5	mTORC2	mTORC2	NNPS
cord-314109-wb45naw2	40	6	)	)	-RRB-
cord-314109-wb45naw2	40	7	,	,	,
cord-314109-wb45naw2	40	8	and	and	CC
cord-314109-wb45naw2	40	9	AMP	AMP	NNP
cord-314109-wb45naw2	40	10	activated	activate	VBD
cord-314109-wb45naw2	40	11	protein	protein	NN
cord-314109-wb45naw2	40	12	kinase	kinase	NN
cord-314109-wb45naw2	40	13	(	(	-LRB-
cord-314109-wb45naw2	40	14	AMPK	AMPK	NNP
cord-314109-wb45naw2	40	15	)	)	-RRB-
cord-314109-wb45naw2	40	16	.	.	.
cord-314109-wb45naw2	41	1	mTOR	mTOR	NNP
cord-314109-wb45naw2	41	2	is	be	VBZ
cord-314109-wb45naw2	41	3	a	a	DT
cord-314109-wb45naw2	41	4	critical	critical	JJ
cord-314109-wb45naw2	41	5	pathway	pathway	NN
cord-314109-wb45naw2	41	6	that	that	WDT
cord-314109-wb45naw2	41	7	oversees	oversee	VBZ
cord-314109-wb45naw2	41	8	cellular	cellular	JJ
cord-314109-wb45naw2	41	9	metabolism	metabolism	NN
cord-314109-wb45naw2	41	10	,	,	,
cord-314109-wb45naw2	41	11	development	development	NN
cord-314109-wb45naw2	41	12	,	,	,
cord-314109-wb45naw2	41	13	survival	survival	NN
cord-314109-wb45naw2	41	14	,	,	,
cord-314109-wb45naw2	41	15	senescence	senescence	NN
cord-314109-wb45naw2	41	16	,	,	,
cord-314109-wb45naw2	41	17	tumorigenesis	tumorigenesis	NN
cord-314109-wb45naw2	41	18	,	,	,
cord-314109-wb45naw2	41	19	and	and	CC
cord-314109-wb45naw2	41	20	inflammation	inflammation	NN
cord-314109-wb45naw2	41	21	[	[	-LRB-
cord-314109-wb45naw2	41	22	7	7	CD
cord-314109-wb45naw2	41	23	,	,	,
cord-314109-wb45naw2	41	24	[	[	-LRB-
cord-314109-wb45naw2	41	25	12	12	CD
cord-314109-wb45naw2	41	26	]	]	-RRB-
cord-314109-wb45naw2	42	1	[	[	-LRB-
cord-314109-wb45naw2	42	2	13	13	CD
cord-314109-wb45naw2	42	3	]	]	-RRB-
cord-314109-wb45naw2	42	4	[	[	-LRB-
cord-314109-wb45naw2	42	5	14	14	CD
cord-314109-wb45naw2	42	6	]	]	-RRB-
cord-314109-wb45naw2	42	7	[	[	-LRB-
cord-314109-wb45naw2	42	8	15	15	CD
cord-314109-wb45naw2	42	9	]	]	-RRB-
cord-314109-wb45naw2	42	10	.	.	.
cord-314109-wb45naw2	43	1	mTOR	mTOR	NNP
cord-314109-wb45naw2	43	2	is	be	VBZ
cord-314109-wb45naw2	43	3	a	a	DT
cord-314109-wb45naw2	43	4	289-kDa	289-kda	CD
cord-314109-wb45naw2	43	5	serine	serine	NN
cord-314109-wb45naw2	43	6	/	/	SYM
cord-314109-wb45naw2	43	7	threonine	threonine	NN
cord-314109-wb45naw2	43	8	protein	protein	NN
cord-314109-wb45naw2	43	9	kinase	kinase	NN
cord-314109-wb45naw2	43	10	.	.	.
cord-314109-wb45naw2	44	1	It	-PRON-	PRP
cord-314109-wb45naw2	44	2	is	be	VBZ
cord-314109-wb45naw2	44	3	also	also	RB
cord-314109-wb45naw2	44	4	termed	term	VBN
cord-314109-wb45naw2	44	5	the	the	DT
cord-314109-wb45naw2	44	6	mammalian	mammalian	JJ
cord-314109-wb45naw2	44	7	target	target	NN
cord-314109-wb45naw2	44	8	of	of	IN
cord-314109-wb45naw2	44	9	rapamycin	rapamycin	NN
cord-314109-wb45naw2	44	10	and	and	CC
cord-314109-wb45naw2	44	11	the	the	DT
cord-314109-wb45naw2	44	12	FK506-binding	FK506-binding	NNP
cord-314109-wb45naw2	44	13	protein	protein	NN
cord-314109-wb45naw2	44	14	12rapamycin	12rapamycin	CD
cord-314109-wb45naw2	44	15	complex	complex	NN
cord-314109-wb45naw2	44	16	-	-	HYPH
cord-314109-wb45naw2	44	17	associated	associate	VBN
cord-314109-wb45naw2	44	18	protein	protein	NN
cord-314109-wb45naw2	44	19	1	1	CD
cord-314109-wb45naw2	44	20	and	and	CC
cord-314109-wb45naw2	44	21	is	be	VBZ
cord-314109-wb45naw2	44	22	encoded	encode	VBN
cord-314109-wb45naw2	44	23	by	by	IN
cord-314109-wb45naw2	44	24	the	the	DT
cord-314109-wb45naw2	44	25	FRAP1	FRAP1	NNP
cord-314109-wb45naw2	44	26	gene	gene	NN
cord-314109-wb45naw2	44	27	[	[	-LRB-
cord-314109-wb45naw2	44	28	16	16	CD
cord-314109-wb45naw2	44	29	]	]	-RRB-
cord-314109-wb45naw2	44	30	.	.	.
cord-314109-wb45naw2	45	1	mTOR	mTOR	NNP
cord-314109-wb45naw2	45	2	functions	function	NNS
cord-314109-wb45naw2	45	3	as	as	IN
cord-314109-wb45naw2	45	4	a	a	DT
cord-314109-wb45naw2	45	5	component	component	NN
cord-314109-wb45naw2	45	6	of	of	IN
cord-314109-wb45naw2	45	7	the	the	DT
cord-314109-wb45naw2	45	8	protein	protein	NN
cord-314109-wb45naw2	45	9	complexes	complex	NNS
cord-314109-wb45naw2	45	10	mTOR	mTOR	NNP
cord-314109-wb45naw2	45	11	Complex	Complex	NNP
cord-314109-wb45naw2	45	12	1	1	CD
cord-314109-wb45naw2	45	13	(	(	-LRB-
cord-314109-wb45naw2	45	14	mTORC1	mtorc1	NN
cord-314109-wb45naw2	45	15	)	)	-RRB-
cord-314109-wb45naw2	45	16	and	and	CC
cord-314109-wb45naw2	45	17	mTOR	mTOR	NNP
cord-314109-wb45naw2	45	18	Complex	Complex	NNP
cord-314109-wb45naw2	45	19	2	2	CD
cord-314109-wb45naw2	45	20	(	(	-LRB-
cord-314109-wb45naw2	45	21	mTORC2	mTORC2	NNPS
cord-314109-wb45naw2	45	22	)	)	-RRB-
cord-314109-wb45naw2	45	23	[	[	-LRB-
cord-314109-wb45naw2	45	24	17	17	CD
cord-314109-wb45naw2	45	25	]	]	-RRB-
cord-314109-wb45naw2	45	26	[	[	-LRB-
cord-314109-wb45naw2	45	27	18	18	CD
cord-314109-wb45naw2	45	28	]	]	-RRB-
cord-314109-wb45naw2	45	29	[	[	-LRB-
cord-314109-wb45naw2	45	30	19	19	CD
cord-314109-wb45naw2	45	31	]	]	-RRB-
cord-314109-wb45naw2	45	32	.	.	.
cord-314109-wb45naw2	46	1	Several	several	JJ
cord-314109-wb45naw2	46	2	strategies	strategy	NNS
cord-314109-wb45naw2	46	3	can	can	MD
cord-314109-wb45naw2	46	4	be	be	VB
cord-314109-wb45naw2	46	5	used	use	VBN
cord-314109-wb45naw2	46	6	to	to	TO
cord-314109-wb45naw2	46	7	control	control	VB
cord-314109-wb45naw2	46	8	mTOR	mTOR	NNP
cord-314109-wb45naw2	46	9	activity	activity	NN
cord-314109-wb45naw2	46	10	.	.	.
cord-314109-wb45naw2	47	1	As	as	IN
cord-314109-wb45naw2	47	2	an	an	DT
cord-314109-wb45naw2	47	3	example	example	NN
cord-314109-wb45naw2	47	4	,	,	,
cord-314109-wb45naw2	47	5	rapamycin	rapamycin	NN
cord-314109-wb45naw2	47	6	is	be	VBZ
cord-314109-wb45naw2	47	7	a	a	DT
cord-314109-wb45naw2	47	8	macrolide	macrolide	JJ
cord-314109-wb45naw2	47	9	antibiotic	antibiotic	JJ
cord-314109-wb45naw2	47	10	in	in	IN
cord-314109-wb45naw2	47	11	Streptomyces	Streptomyces	NNP
cord-314109-wb45naw2	47	12	hygroscopicus	hygroscopicus	NNP
cord-314109-wb45naw2	47	13	that	that	WDT
cord-314109-wb45naw2	47	14	blocks	block	VBZ
cord-314109-wb45naw2	47	15	mTOR	mTOR	NNP
cord-314109-wb45naw2	47	16	activity	activity	NN
cord-314109-wb45naw2	47	17	[	[	-LRB-
cord-314109-wb45naw2	47	18	20	20	CD
cord-314109-wb45naw2	47	19	]	]	-RRB-
cord-314109-wb45naw2	47	20	[	[	-LRB-
cord-314109-wb45naw2	47	21	21	21	CD
cord-314109-wb45naw2	47	22	]	]	-RRB-
cord-314109-wb45naw2	47	23	[	[	-LRB-
cord-314109-wb45naw2	47	24	22	22	CD
cord-314109-wb45naw2	47	25	]	]	-RRB-
cord-314109-wb45naw2	47	26	[	[	-LRB-
cord-314109-wb45naw2	47	27	23	23	CD
cord-314109-wb45naw2	47	28	]	]	-RRB-
cord-314109-wb45naw2	47	29	[	[	-LRB-
cord-314109-wb45naw2	47	30	24	24	CD
cord-314109-wb45naw2	47	31	]	]	-RRB-
cord-314109-wb45naw2	47	32	.	.	.
cord-314109-wb45naw2	48	1	Rapamycin	Rapamycin	NNP
cord-314109-wb45naw2	48	2	inhibits	inhibit	VBZ
cord-314109-wb45naw2	48	3	the	the	DT
cord-314109-wb45naw2	48	4	activity	activity	NN
cord-314109-wb45naw2	48	5	of	of	IN
cord-314109-wb45naw2	48	6	mTORC1	mTORC1	NNP
cord-314109-wb45naw2	48	7	by	by	IN
cord-314109-wb45naw2	48	8	binding	bind	VBG
cord-314109-wb45naw2	48	9	to	to	IN
cord-314109-wb45naw2	48	10	immunophilin	immunophilin	NNP
cord-314109-wb45naw2	49	1	FK-506-binding	fk-506-binde	VBG
cord-314109-wb45naw2	50	1	protein	protein	NN
cord-314109-wb45naw2	50	2	12	12	CD
cord-314109-wb45naw2	50	3	(	(	-LRB-
cord-314109-wb45naw2	50	4	FKBP12	FKBP12	NNP
cord-314109-wb45naw2	50	5	)	)	-RRB-
cord-314109-wb45naw2	50	6	that	that	WDT
cord-314109-wb45naw2	50	7	attaches	attach	VBZ
cord-314109-wb45naw2	50	8	to	to	IN
cord-314109-wb45naw2	50	9	the	the	DT
cord-314109-wb45naw2	50	10	FKBP12	FKBP12	NNP
cord-314109-wb45naw2	50	11	-rapamycin	-rapamycin	RBS
cord-314109-wb45naw2	50	12	-	-	HYPH
cord-314109-wb45naw2	50	13	binding	bind	VBG
cord-314109-wb45naw2	50	14	domain	domain	NN
cord-314109-wb45naw2	50	15	(	(	-LRB-
cord-314109-wb45naw2	50	16	FRB	FRB	NNP
cord-314109-wb45naw2	50	17	)	)	-RRB-
cord-314109-wb45naw2	50	18	at	at	IN
cord-314109-wb45naw2	50	19	the	the	DT
cord-314109-wb45naw2	50	20	carboxy	carboxy	NN
cord-314109-wb45naw2	50	21	(	(	-LRB-
cord-314109-wb45naw2	50	22	C)-terminal	C)-terminal	NNP
cord-314109-wb45naw2	50	23	of	of	IN
cord-314109-wb45naw2	50	24	mTOR	mTOR	NNP
cord-314109-wb45naw2	50	25	to	to	TO
cord-314109-wb45naw2	50	26	interfere	interfere	VB
cord-314109-wb45naw2	50	27	with	with	IN
cord-314109-wb45naw2	50	28	the	the	DT
cord-314109-wb45naw2	50	29	FRB	FRB	NNP
cord-314109-wb45naw2	50	30	domain	domain	NN
cord-314109-wb45naw2	50	31	of	of	IN
cord-314109-wb45naw2	50	32	mTORC1	mTORC1	NNP
cord-314109-wb45naw2	50	33	[	[	-LRB-
cord-314109-wb45naw2	50	34	20	20	CD
cord-314109-wb45naw2	50	35	]	]	-RRB-
cord-314109-wb45naw2	50	36	.	.	.
cord-314109-wb45naw2	51	1	mTORC1	mTORC1	NNP
cord-314109-wb45naw2	51	2	consists	consist	VBZ
cord-314109-wb45naw2	51	3	of	of	IN
cord-314109-wb45naw2	51	4	Raptor	Raptor	NNP
cord-314109-wb45naw2	51	5	,	,	,
cord-314109-wb45naw2	51	6	Deptor	Deptor	NNP
cord-314109-wb45naw2	51	7	(	(	-LRB-
cord-314109-wb45naw2	51	8	DEP	DEP	NNP
cord-314109-wb45naw2	51	9	domaincontaining	domaincontaining	NN
cord-314109-wb45naw2	51	10	mTOR	mTOR	NNP
cord-314109-wb45naw2	51	11	interacting	interact	VBG
cord-314109-wb45naw2	51	12	protein	protein	NNP
cord-314109-wb45naw2	51	13	)	)	-RRB-
cord-314109-wb45naw2	51	14	,	,	,
cord-314109-wb45naw2	51	15	the	the	DT
cord-314109-wb45naw2	51	16	proline	proline	JJ
cord-314109-wb45naw2	51	17	rich	rich	JJ
cord-314109-wb45naw2	51	18	Akt	Akt	NNP
cord-314109-wb45naw2	51	19	substrate	substrate	NN
cord-314109-wb45naw2	51	20	40	40	CD
cord-314109-wb45naw2	51	21	kDa	kDa	NNS
cord-314109-wb45naw2	51	22	(	(	-LRB-
cord-314109-wb45naw2	51	23	PRAS40	PRAS40	NNP
cord-314109-wb45naw2	51	24	)	)	-RRB-
cord-314109-wb45naw2	51	25	,	,	,
cord-314109-wb45naw2	51	26	and	and	CC
cord-314109-wb45naw2	51	27	mammalian	mammalian	JJ
cord-314109-wb45naw2	51	28	lethal	lethal	NN
cord-314109-wb45naw2	51	29	with	with	IN
cord-314109-wb45naw2	51	30	Sec13	Sec13	NNP
cord-314109-wb45naw2	51	31	protein	protein	NN
cord-314109-wb45naw2	51	32	8	8	CD
cord-314109-wb45naw2	51	33	,	,	,
cord-314109-wb45naw2	52	1	termed	term	VBN
cord-314109-wb45naw2	52	2	mLST8	mLST8	NNP
cord-314109-wb45naw2	52	3	(	(	-LRB-
cord-314109-wb45naw2	52	4	mLST8	mlst8	NN
cord-314109-wb45naw2	52	5	)	)	-RRB-
cord-314109-wb45naw2	53	1	[	[	-LRB-
cord-314109-wb45naw2	53	2	18	18	CD
cord-314109-wb45naw2	53	3	]	]	-RRB-
cord-314109-wb45naw2	53	4	.	.	.
cord-314109-wb45naw2	54	1	mTOR	mTOR	NNP
cord-314109-wb45naw2	54	2	can	can	MD
cord-314109-wb45naw2	54	3	oversee	oversee	VB
cord-314109-wb45naw2	54	4	Raptor	Raptor	NNP
cord-314109-wb45naw2	54	5	activity	activity	NN
cord-314109-wb45naw2	54	6	that	that	WDT
cord-314109-wb45naw2	54	7	can	can	MD
cord-314109-wb45naw2	54	8	be	be	VB
cord-314109-wb45naw2	54	9	inhibited	inhibit	VBN
cord-314109-wb45naw2	54	10	by	by	IN
cord-314109-wb45naw2	54	11	rapamycin	rapamycin	NNS
cord-314109-wb45naw2	54	12	[	[	-LRB-
cord-314109-wb45naw2	54	13	25	25	CD
cord-314109-wb45naw2	54	14	]	]	-RRB-
cord-314109-wb45naw2	54	15	as	as	IN
cord-314109-wb45naw2	54	16	previously	previously	RB
cord-314109-wb45naw2	54	17	described	describe	VBN
cord-314109-wb45naw2	54	18	.	.	.
cord-314109-wb45naw2	55	1	PRAS40	PRAS40	NNP
cord-314109-wb45naw2	55	2	blocks	block	VBZ
cord-314109-wb45naw2	55	3	the	the	DT
cord-314109-wb45naw2	55	4	activity	activity	NN
cord-314109-wb45naw2	55	5	of	of	IN
cord-314109-wb45naw2	55	6	mTORC1	mTORC1	NNP
cord-314109-wb45naw2	55	7	by	by	IN
cord-314109-wb45naw2	55	8	inhibiting	inhibit	VBG
cord-314109-wb45naw2	55	9	the	the	DT
cord-314109-wb45naw2	55	10	association	association	NN
cord-314109-wb45naw2	55	11	of	of	IN
cord-314109-wb45naw2	55	12	p70	p70	CD
cord-314109-wb45naw2	55	13	ribosomal	ribosomal	JJ
cord-314109-wb45naw2	55	14	S6	S6	NNP
cord-314109-wb45naw2	55	15	kinase	kinase	NN
cord-314109-wb45naw2	55	16	(	(	-LRB-
cord-314109-wb45naw2	55	17	p70S6	p70S6	NNP
cord-314109-wb45naw2	55	18	K	K	NNP
cord-314109-wb45naw2	55	19	)	)	-RRB-
cord-314109-wb45naw2	55	20	and	and	CC
cord-314109-wb45naw2	55	21	the	the	DT
cord-314109-wb45naw2	55	22	eukaryotic	eukaryotic	JJ
cord-314109-wb45naw2	55	23	initiation	initiation	NN
cord-314109-wb45naw2	55	24	factor	factor	NN
cord-314109-wb45naw2	55	25	4E	4E	NNP
cord-314109-wb45naw2	56	1	(	(	-LRB-
cord-314109-wb45naw2	56	2	eIF4E)-binding	eif4e)-binde	VBG
cord-314109-wb45naw2	56	3	protein	protein	NN
cord-314109-wb45naw2	56	4	1	1	CD
cord-314109-wb45naw2	56	5	(	(	-LRB-
cord-314109-wb45naw2	56	6	4EBP1	4ebp1	CD
cord-314109-wb45naw2	56	7	)	)	-RRB-
cord-314109-wb45naw2	56	8	with	with	IN
cord-314109-wb45naw2	56	9	Raptor	Raptor	NNP
cord-314109-wb45naw2	56	10	[	[	-LRB-
cord-314109-wb45naw2	56	11	13	13	CD
cord-314109-wb45naw2	56	12	,	,	,
cord-314109-wb45naw2	56	13	[	[	-LRB-
cord-314109-wb45naw2	56	14	26	26	CD
cord-314109-wb45naw2	56	15	]	]	-RRB-
cord-314109-wb45naw2	56	16	[	[	-LRB-
cord-314109-wb45naw2	56	17	27	27	CD
cord-314109-wb45naw2	56	18	]	]	-RRB-
cord-314109-wb45naw2	56	19	[	[	-LRB-
cord-314109-wb45naw2	56	20	28	28	CD
cord-314109-wb45naw2	56	21	]	]	-RRB-
cord-314109-wb45naw2	56	22	.	.	.
cord-314109-wb45naw2	57	1	Protein	protein	NN
cord-314109-wb45naw2	57	2	kinase	kinase	NN
cord-314109-wb45naw2	57	3	B	B	NNP
cord-314109-wb45naw2	57	4	(	(	-LRB-
cord-314109-wb45naw2	57	5	Akt	Akt	NNP
cord-314109-wb45naw2	57	6	)	)	-RRB-
cord-314109-wb45naw2	57	7	is	be	VBZ
cord-314109-wb45naw2	57	8	a	a	DT
cord-314109-wb45naw2	57	9	part	part	NN
cord-314109-wb45naw2	57	10	of	of	IN
cord-314109-wb45naw2	57	11	this	this	DT
cord-314109-wb45naw2	57	12	pathway	pathway	NN
cord-314109-wb45naw2	57	13	since	since	IN
cord-314109-wb45naw2	57	14	the	the	DT
cord-314109-wb45naw2	57	15	activity	activity	NN
cord-314109-wb45naw2	57	16	of	of	IN
cord-314109-wb45naw2	57	17	mTORC1	mTORC1	NNP
cord-314109-wb45naw2	57	18	is	be	VBZ
cord-314109-wb45naw2	57	19	increased	increase	VBN
cord-314109-wb45naw2	57	20	once	once	IN
cord-314109-wb45naw2	57	21	Akt	Akt	NNP
cord-314109-wb45naw2	57	22	phosphorylates	phosphorylate	VBZ
cord-314109-wb45naw2	58	1	PRAS40	pras40	VB
cord-314109-wb45naw2	58	2	[	[	-LRB-
cord-314109-wb45naw2	58	3	22	22	CD
cord-314109-wb45naw2	58	4	]	]	-RRB-
cord-314109-wb45naw2	58	5	.	.	.
cord-314109-wb45naw2	59	1	This	this	DT
cord-314109-wb45naw2	59	2	process	process	NN
cord-314109-wb45naw2	59	3	releases	release	VBZ
cord-314109-wb45naw2	59	4	the	the	DT
cord-314109-wb45naw2	59	5	binding	binding	NN
cord-314109-wb45naw2	59	6	of	of	IN
cord-314109-wb45naw2	59	7	PRAS40	PRAS40	NNP
cord-314109-wb45naw2	59	8	to	to	IN
cord-314109-wb45naw2	59	9	Raptor	Raptor	NNP
cord-314109-wb45naw2	59	10	and	and	CC
cord-314109-wb45naw2	59	11	sequesters	sequester	VBZ
cord-314109-wb45naw2	59	12	PRAS40	pras40	VBP
cord-314109-wb45naw2	59	13	in	in	IN
cord-314109-wb45naw2	59	14	the	the	DT
cord-314109-wb45naw2	59	15	cytoplasm	cytoplasm	NN
cord-314109-wb45naw2	59	16	with	with	IN
cord-314109-wb45naw2	59	17	the	the	DT
cord-314109-wb45naw2	59	18	docking	docking	NN
cord-314109-wb45naw2	59	19	protein	protein	NN
cord-314109-wb45naw2	59	20	14	14	CD
cord-314109-wb45naw2	59	21	-	-	SYM
cord-314109-wb45naw2	59	22	3	3	CD
cord-314109-wb45naw2	59	23	-	-	SYM
cord-314109-wb45naw2	59	24	3	3	CD
cord-314109-wb45naw2	59	25	[	[	-LRB-
cord-314109-wb45naw2	59	26	27	27	CD
cord-314109-wb45naw2	59	27	,	,	,
cord-314109-wb45naw2	59	28	29	29	CD
cord-314109-wb45naw2	59	29	,	,	,
cord-314109-wb45naw2	59	30	30	30	CD
cord-314109-wb45naw2	59	31	]	]	-RRB-
cord-314109-wb45naw2	59	32	.	.	.
cord-314109-wb45naw2	60	1	Deptor	Deptor	NNP
cord-314109-wb45naw2	60	2	prevents	prevent	VBZ
cord-314109-wb45naw2	60	3	the	the	DT
cord-314109-wb45naw2	60	4	activity	activity	NN
cord-314109-wb45naw2	60	5	of	of	IN
cord-314109-wb45naw2	60	6	mTORC1	mTORC1	NNP
cord-314109-wb45naw2	60	7	by	by	IN
cord-314109-wb45naw2	60	8	binding	bind	VBG
cord-314109-wb45naw2	60	9	to	to	IN
cord-314109-wb45naw2	60	10	the	the	DT
cord-314109-wb45naw2	60	11	FAT	fat	JJ
cord-314109-wb45naw2	60	12	domain	domain	NN
cord-314109-wb45naw2	60	13	(	(	-LRB-
cord-314109-wb45naw2	60	14	FKBP12rapamycin	FKBP12rapamycin	NNS
cord-314109-wb45naw2	60	15	-	-	HYPH
cord-314109-wb45naw2	60	16	associated	associate	VBN
cord-314109-wb45naw2	60	17	protein	protein	NN
cord-314109-wb45naw2	60	18	(	(	-LRB-
cord-314109-wb45naw2	60	19	FRAP	FRAP	NNP
cord-314109-wb45naw2	60	20	)	)	-RRB-
cord-314109-wb45naw2	60	21	,	,	,
cord-314109-wb45naw2	60	22	ataxia	ataxia	NN
cord-314109-wb45naw2	60	23	-	-	HYPH
cord-314109-wb45naw2	60	24	telangiectasia	telangiectasia	NN
cord-314109-wb45naw2	60	25	(	(	-LRB-
cord-314109-wb45naw2	60	26	ATM	ATM	NNP
cord-314109-wb45naw2	60	27	)	)	-RRB-
cord-314109-wb45naw2	60	28	,	,	,
cord-314109-wb45naw2	60	29	and	and	CC
cord-314109-wb45naw2	60	30	the	the	DT
cord-314109-wb45naw2	60	31	transactivation	transactivation	NN
cord-314109-wb45naw2	60	32	/	/	SYM
cord-314109-wb45naw2	60	33	transformation	transformation	NN
cord-314109-wb45naw2	60	34	domainassociated	domainassociated	JJ
cord-314109-wb45naw2	60	35	protein	protein	NN
cord-314109-wb45naw2	60	36	)	)	-RRB-
cord-314109-wb45naw2	60	37	of	of	IN
cord-314109-wb45naw2	60	38	mTOR	mTOR	NNP
cord-314109-wb45naw2	60	39	.	.	.
cord-314109-wb45naw2	61	1	During	during	IN
cord-314109-wb45naw2	61	2	the	the	DT
cord-314109-wb45naw2	61	3	suppression	suppression	NN
cord-314109-wb45naw2	61	4	of	of	IN
cord-314109-wb45naw2	61	5	Deptor	Deptor	NNP
cord-314109-wb45naw2	61	6	activity	activity	NN
cord-314109-wb45naw2	61	7	,	,	,
cord-314109-wb45naw2	61	8	Akt	Akt	NNP
cord-314109-wb45naw2	61	9	,	,	,
cord-314109-wb45naw2	61	10	mTORC1	mtorc1	CD
cord-314109-wb45naw2	61	11	,	,	,
cord-314109-wb45naw2	61	12	and	and	CC
cord-314109-wb45naw2	61	13	mTORC2	mTORC2	JJS
cord-314109-wb45naw2	61	14	activities	activity	NNS
cord-314109-wb45naw2	61	15	are	be	VBP
cord-314109-wb45naw2	61	16	increased	increase	VBN
cord-314109-wb45naw2	61	17	[	[	-LRB-
cord-314109-wb45naw2	61	18	31	31	CD
cord-314109-wb45naw2	61	19	]	]	-RRB-
cord-314109-wb45naw2	61	20	.	.	.
cord-314109-wb45naw2	62	1	mLST8	mLST8	NNP
cord-314109-wb45naw2	62	2	is	be	VBZ
cord-314109-wb45naw2	62	3	known	know	VBN
cord-314109-wb45naw2	62	4	to	to	TO
cord-314109-wb45naw2	62	5	foster	foster	VB
cord-314109-wb45naw2	62	6	mTOR	mTOR	NNP
cord-314109-wb45naw2	62	7	kinase	kinase	NN
cord-314109-wb45naw2	62	8	activity	activity	NN
cord-314109-wb45naw2	62	9	.	.	.
cord-314109-wb45naw2	63	1	This	this	DT
cord-314109-wb45naw2	63	2	process	process	NN
cord-314109-wb45naw2	63	3	involves	involve	VBZ
cord-314109-wb45naw2	63	4	the	the	DT
cord-314109-wb45naw2	63	5	binding	binding	NN
cord-314109-wb45naw2	63	6	of	of	IN
cord-314109-wb45naw2	63	7	p70S6	p70s6	CD
cord-314109-wb45naw2	63	8	K	K	NNP
cord-314109-wb45naw2	63	9	and	and	CC
cord-314109-wb45naw2	63	10	4EBP1	4ebp1	CD
cord-314109-wb45naw2	63	11	to	to	IN
cord-314109-wb45naw2	63	12	Raptor	Raptor	NNP
cord-314109-wb45naw2	63	13	[	[	-LRB-
cord-314109-wb45naw2	63	14	32	32	CD
cord-314109-wb45naw2	63	15	]	]	-RRB-
cord-314109-wb45naw2	63	16	.	.	.
cord-314109-wb45naw2	64	1	mTORC2	mTORC2	NNPS
cord-314109-wb45naw2	64	2	has	have	VBZ
cord-314109-wb45naw2	64	3	the	the	DT
cord-314109-wb45naw2	64	4	components	component	NNS
cord-314109-wb45naw2	64	5	of	of	IN
cord-314109-wb45naw2	64	6	Rictor	Rictor	NNP
cord-314109-wb45naw2	64	7	,	,	,
cord-314109-wb45naw2	64	8	Deptor	Deptor	NNP
cord-314109-wb45naw2	64	9	,	,	,
cord-314109-wb45naw2	64	10	mLST8	mlst8	CC
cord-314109-wb45naw2	64	11	,	,	,
cord-314109-wb45naw2	64	12	the	the	DT
cord-314109-wb45naw2	64	13	mammalian	mammalian	JJ
cord-314109-wb45naw2	64	14	stress	stress	NN
cord-314109-wb45naw2	64	15	-	-	HYPH
cord-314109-wb45naw2	64	16	activated	activate	VBN
cord-314109-wb45naw2	64	17	protein	protein	NN
cord-314109-wb45naw2	64	18	kinase	kinase	NN
cord-314109-wb45naw2	64	19	interacting	interact	VBG
cord-314109-wb45naw2	64	20	protein	protein	NN
cord-314109-wb45naw2	64	21	(	(	-LRB-
cord-314109-wb45naw2	64	22	mSIN1	mSIN1	NNS
cord-314109-wb45naw2	64	23	)	)	-RRB-
cord-314109-wb45naw2	64	24	,	,	,
cord-314109-wb45naw2	64	25	and	and	CC
cord-314109-wb45naw2	64	26	the	the	DT
cord-314109-wb45naw2	64	27	protein	protein	NN
cord-314109-wb45naw2	64	28	observed	observe	VBD
cord-314109-wb45naw2	64	29	with	with	IN
cord-314109-wb45naw2	64	30	Rictor-1	Rictor-1	NNP
cord-314109-wb45naw2	64	31	(	(	-LRB-
cord-314109-wb45naw2	64	32	Protor-1	Protor-1	NNP
cord-314109-wb45naw2	64	33	)	)	-RRB-
cord-314109-wb45naw2	64	34	[	[	-LRB-
cord-314109-wb45naw2	64	35	33	33	CD
cord-314109-wb45naw2	64	36	]	]	-RRB-
cord-314109-wb45naw2	64	37	.	.	.
cord-314109-wb45naw2	65	1	mTORC2	mTORC2	NNP
cord-314109-wb45naw2	65	2	regulates	regulate	VBZ
cord-314109-wb45naw2	65	3	cytoskeleton	cytoskeleton	NN
cord-314109-wb45naw2	65	4	remodeling	remodel	VBG
cord-314109-wb45naw2	65	5	with	with	IN
cord-314109-wb45naw2	65	6	PKCα	PKCα	NNS
cord-314109-wb45naw2	65	7	and	and	CC
cord-314109-wb45naw2	65	8	cell	cell	NN
cord-314109-wb45naw2	65	9	migration	migration	NN
cord-314109-wb45naw2	65	10	with	with	IN
cord-314109-wb45naw2	65	11	the	the	DT
cord-314109-wb45naw2	65	12	Rac	Rac	NNP
cord-314109-wb45naw2	65	13	guanine	guanine	NN
cord-314109-wb45naw2	65	14	nucleotide	nucleotide	JJ
cord-314109-wb45naw2	65	15	exchange	exchange	NN
cord-314109-wb45naw2	65	16	factors	factor	NNS
cord-314109-wb45naw2	65	17	P	P	NNP
cord-314109-wb45naw2	65	18	-	-	HYPH
cord-314109-wb45naw2	65	19	Rex1	Rex1	NNP
cord-314109-wb45naw2	65	20	and	and	CC
cord-314109-wb45naw2	65	21	P	P	NNP
cord-314109-wb45naw2	65	22	-	-	HYPH
cord-314109-wb45naw2	65	23	Rex2	Rex2	NNP
cord-314109-wb45naw2	65	24	,	,	,
cord-314109-wb45naw2	65	25	and	and	CC
cord-314109-wb45naw2	65	26	with	with	IN
cord-314109-wb45naw2	65	27	Rho	Rho	NNP
cord-314109-wb45naw2	65	28	signaling	signal	VBG
cord-314109-wb45naw2	65	29	[	[	-LRB-
cord-314109-wb45naw2	65	30	34	34	CD
cord-314109-wb45naw2	65	31	]	]	-RRB-
cord-314109-wb45naw2	65	32	.	.	.
cord-314109-wb45naw2	66	1	mTORC2	mTORC2	NNPS
cord-314109-wb45naw2	66	2	can	can	MD
cord-314109-wb45naw2	66	3	increase	increase	VB
cord-314109-wb45naw2	66	4	the	the	DT
cord-314109-wb45naw2	66	5	activity	activity	NN
cord-314109-wb45naw2	66	6	of	of	IN
cord-314109-wb45naw2	66	7	protein	protein	NN
cord-314109-wb45naw2	66	8	kinases	kinase	NNS
cord-314109-wb45naw2	66	9	including	include	VBG
cord-314109-wb45naw2	66	10	glucocorticoid	glucocorticoid	NN
cord-314109-wb45naw2	66	11	induced	induce	VBN
cord-314109-wb45naw2	66	12	protein	protein	NN
cord-314109-wb45naw2	66	13	kinase	kinase	NN
cord-314109-wb45naw2	66	14	1	1	CD
cord-314109-wb45naw2	66	15	(	(	-LRB-
cord-314109-wb45naw2	66	16	SGK1	SGK1	NNP
cord-314109-wb45naw2	66	17	)	)	-RRB-
cord-314109-wb45naw2	66	18	,	,	,
cord-314109-wb45naw2	66	19	a	a	DT
cord-314109-wb45naw2	66	20	member	member	NN
cord-314109-wb45naw2	66	21	of	of	IN
cord-314109-wb45naw2	66	22	the	the	DT
cord-314109-wb45naw2	66	23	protein	protein	NN
cord-314109-wb45naw2	66	24	kinase	kinase	VBZ
cord-314109-wb45naw2	66	25	A	A	NNP
cord-314109-wb45naw2	66	26	/	/	SYM
cord-314109-wb45naw2	66	27	protein	protein	NN
cord-314109-wb45naw2	66	28	kinase	kinase	VBZ
cord-314109-wb45naw2	66	29	G	g	NN
cord-314109-wb45naw2	66	30	/	/	SYM
cord-314109-wb45naw2	66	31	protein	protein	NN
cord-314109-wb45naw2	66	32	kinase	kinase	NN
cord-314109-wb45naw2	66	33	C	C	NNP
cord-314109-wb45naw2	66	34	(	(	-LRB-
cord-314109-wb45naw2	66	35	AGC	AGC	NNP
cord-314109-wb45naw2	66	36	)	)	-RRB-
cord-314109-wb45naw2	66	37	family	family	NN
cord-314109-wb45naw2	66	38	of	of	IN
cord-314109-wb45naw2	66	39	protein	protein	NN
cord-314109-wb45naw2	66	40	kinases	kinase	NNS
cord-314109-wb45naw2	66	41	.	.	.
cord-314109-wb45naw2	67	1	Protor-1	Protor-1	NNP
cord-314109-wb45naw2	67	2	is	be	VBZ
cord-314109-wb45naw2	67	3	a	a	DT
cord-314109-wb45naw2	67	4	Rictor	Rictor	NNP
cord-314109-wb45naw2	67	5	-	-	HYPH
cord-314109-wb45naw2	67	6	binding	bind	VBG
cord-314109-wb45naw2	67	7	subunit	subunit	NN
cord-314109-wb45naw2	67	8	of	of	IN
cord-314109-wb45naw2	67	9	mTORC2	mTORC2	JJS
cord-314109-wb45naw2	67	10	and	and	CC
cord-314109-wb45naw2	67	11	increases	increase	VBZ
cord-314109-wb45naw2	67	12	the	the	DT
cord-314109-wb45naw2	67	13	activity	activity	NN
cord-314109-wb45naw2	67	14	of	of	IN
cord-314109-wb45naw2	67	15	SGK1	SGK1	NNP
cord-314109-wb45naw2	67	16	[	[	-LRB-
cord-314109-wb45naw2	67	17	35	35	CD
cord-314109-wb45naw2	67	18	,	,	,
cord-314109-wb45naw2	67	19	36	36	CD
cord-314109-wb45naw2	67	20	]	]	-RRB-
cord-314109-wb45naw2	67	21	.	.	.
cord-314109-wb45naw2	68	1	mSin1	mSin1	NNP
cord-314109-wb45naw2	68	2	is	be	VBZ
cord-314109-wb45naw2	68	3	needed	need	VBN
cord-314109-wb45naw2	68	4	for	for	IN
cord-314109-wb45naw2	68	5	the	the	DT
cord-314109-wb45naw2	68	6	assembly	assembly	NN
cord-314109-wb45naw2	68	7	of	of	IN
cord-314109-wb45naw2	68	8	mTORC2	mTORC2	NNPS
cord-314109-wb45naw2	68	9	and	and	CC
cord-314109-wb45naw2	68	10	for	for	IN
cord-314109-wb45naw2	68	11	mTORC2	mTORC2	NNPS
cord-314109-wb45naw2	68	12	to	to	TO
cord-314109-wb45naw2	68	13	phosphorylate	phosphorylate	VB
cord-314109-wb45naw2	68	14	Akt	Akt	NNP
cord-314109-wb45naw2	68	15	[	[	-LRB-
cord-314109-wb45naw2	68	16	37	37	CD
cord-314109-wb45naw2	68	17	]	]	-RRB-
cord-314109-wb45naw2	68	18	.	.	.
cord-314109-wb45naw2	69	1	Rictor	Rictor	NNP
cord-314109-wb45naw2	69	2	and	and	CC
cord-314109-wb45naw2	69	3	mSIN1	mSIN1	NNS
cord-314109-wb45naw2	69	4	can	can	MD
cord-314109-wb45naw2	69	5	enhance	enhance	VB
cord-314109-wb45naw2	69	6	cell	cell	NN
cord-314109-wb45naw2	69	7	survival	survival	NN
cord-314109-wb45naw2	69	8	and	and	CC
cord-314109-wb45naw2	69	9	are	be	VBP
cord-314109-wb45naw2	69	10	known	know	VBN
cord-314109-wb45naw2	69	11	to	to	TO
cord-314109-wb45naw2	69	12	phosphorylate	phosphorylate	VB
cord-314109-wb45naw2	69	13	Akt	Akt	NNP
cord-314109-wb45naw2	69	14	at	at	IN
cord-314109-wb45naw2	69	15	serine	serine	NN
cord-314109-wb45naw2	69	16	473	473	CD
cord-314109-wb45naw2	69	17	and	and	CC
cord-314109-wb45naw2	69	18	promote	promote	VB
cord-314109-wb45naw2	69	19	threonine	threonine	NN
cord-314109-wb45naw2	69	20	308	308	CD
cord-314109-wb45naw2	69	21	phosphorylation	phosphorylation	NN
cord-314109-wb45naw2	69	22	by	by	IN
cord-314109-wb45naw2	69	23	phosphoinositide	phosphoinositide	JJ
cord-314109-wb45naw2	69	24	-	-	HYPH
cord-314109-wb45naw2	69	25	dependent	dependent	JJ
cord-314109-wb45naw2	69	26	kinase	kinase	NN
cord-314109-wb45naw2	69	27	1	1	CD
cord-314109-wb45naw2	69	28	(	(	-LRB-
cord-314109-wb45naw2	69	29	PDK1	PDK1	NNP
cord-314109-wb45naw2	69	30	)	)	-RRB-
cord-314109-wb45naw2	69	31	.	.	.
cord-314109-wb45naw2	70	1	The	the	DT
cord-314109-wb45naw2	70	2	mTOR	mtor	NN
cord-314109-wb45naw2	70	3	pathway	pathway	NN
cord-314109-wb45naw2	70	4	is	be	VBZ
cord-314109-wb45naw2	70	5	intimately	intimately	RB
cord-314109-wb45naw2	70	6	associated	associate	VBN
cord-314109-wb45naw2	70	7	with	with	IN
cord-314109-wb45naw2	70	8	AMPK	AMPK	NNP
cord-314109-wb45naw2	70	9	[	[	-LRB-
cord-314109-wb45naw2	70	10	38	38	CD
cord-314109-wb45naw2	70	11	]	]	-RRB-
cord-314109-wb45naw2	70	12	[	[	-LRB-
cord-314109-wb45naw2	70	13	39	39	CD
cord-314109-wb45naw2	70	14	]	]	-RRB-
cord-314109-wb45naw2	70	15	[	[	-LRB-
cord-314109-wb45naw2	70	16	40	40	CD
cord-314109-wb45naw2	70	17	]	]	-RRB-
cord-314109-wb45naw2	70	18	[	[	-LRB-
cord-314109-wb45naw2	70	19	41	41	CD
cord-314109-wb45naw2	70	20	]	]	-RRB-
cord-314109-wb45naw2	70	21	[	[	-LRB-
cord-314109-wb45naw2	70	22	42	42	CD
cord-314109-wb45naw2	70	23	]	]	-RRB-
cord-314109-wb45naw2	70	24	[	[	-LRB-
cord-314109-wb45naw2	70	25	43	43	CD
cord-314109-wb45naw2	70	26	]	]	-RRB-
cord-314109-wb45naw2	70	27	.	.	.
cord-314109-wb45naw2	71	1	Together	together	RB
cord-314109-wb45naw2	71	2	mTOR	mTOR	NNP
cord-314109-wb45naw2	71	3	and	and	CC
cord-314109-wb45naw2	71	4	AMPK	AMPK	NNP
cord-314109-wb45naw2	71	5	can	can	MD
cord-314109-wb45naw2	71	6	regulate	regulate	VB
cord-314109-wb45naw2	71	7	a	a	DT
cord-314109-wb45naw2	71	8	number	number	NN
cord-314109-wb45naw2	71	9	of	of	IN
cord-314109-wb45naw2	71	10	pathways	pathway	NNS
cord-314109-wb45naw2	71	11	linked	link	VBN
cord-314109-wb45naw2	71	12	to	to	IN
cord-314109-wb45naw2	71	13	oxidative	oxidative	JJ
cord-314109-wb45naw2	71	14	stress	stress	NN
cord-314109-wb45naw2	71	15	,	,	,
cord-314109-wb45naw2	71	16	mitochondrial	mitochondrial	JJ
cord-314109-wb45naw2	71	17	dysfunction	dysfunction	NN
cord-314109-wb45naw2	71	18	,	,	,
cord-314109-wb45naw2	71	19	and	and	CC
cord-314109-wb45naw2	71	20	immune	immune	JJ
cord-314109-wb45naw2	71	21	system	system	NN
cord-314109-wb45naw2	71	22	maintenance	maintenance	NN
cord-314109-wb45naw2	71	23	[	[	-LRB-
cord-314109-wb45naw2	71	24	13	13	CD
cord-314109-wb45naw2	71	25	,	,	,
cord-314109-wb45naw2	71	26	15	15	CD
cord-314109-wb45naw2	71	27	,	,	,
cord-314109-wb45naw2	71	28	[	[	-LRB-
cord-314109-wb45naw2	71	29	43	43	CD
cord-314109-wb45naw2	71	30	]	]	-RRB-
cord-314109-wb45naw2	71	31	[	[	-LRB-
cord-314109-wb45naw2	71	32	44	44	CD
cord-314109-wb45naw2	71	33	]	]	-RRB-
cord-314109-wb45naw2	71	34	[	[	-LRB-
cord-314109-wb45naw2	71	35	45	45	CD
cord-314109-wb45naw2	71	36	]	]	-RRB-
cord-314109-wb45naw2	71	37	[	[	-LRB-
cord-314109-wb45naw2	71	38	46	46	CD
cord-314109-wb45naw2	71	39	]	]	-RRB-
cord-314109-wb45naw2	71	40	[	[	-LRB-
cord-314109-wb45naw2	71	41	47	47	CD
cord-314109-wb45naw2	71	42	]	]	-RRB-
cord-314109-wb45naw2	71	43	[	[	-LRB-
cord-314109-wb45naw2	71	44	48	48	CD
cord-314109-wb45naw2	71	45	]	]	-RRB-
cord-314109-wb45naw2	71	46	[	[	-LRB-
cord-314109-wb45naw2	71	47	49	49	CD
cord-314109-wb45naw2	71	48	]	]	-RRB-
cord-314109-wb45naw2	71	49	.	.	.
cord-314109-wb45naw2	72	1	AMPK	AMPK	NNP
cord-314109-wb45naw2	72	2	can	can	MD
cord-314109-wb45naw2	72	3	inhibit	inhibit	VB
cord-314109-wb45naw2	72	4	mTORC1	mTORC1	NNP
cord-314109-wb45naw2	72	5	activity	activity	NN
cord-314109-wb45naw2	72	6	through	through	IN
cord-314109-wb45naw2	72	7	the	the	DT
cord-314109-wb45naw2	72	8	hamartin	hamartin	NN
cord-314109-wb45naw2	72	9	(	(	-LRB-
cord-314109-wb45naw2	72	10	tuberous	tuberous	JJ
cord-314109-wb45naw2	72	11	sclerosis	sclerosis	NN
cord-314109-wb45naw2	72	12	1)/tuberin	1)/tuberin	CD
cord-314109-wb45naw2	72	13	(	(	-LRB-
cord-314109-wb45naw2	72	14	tuberous	tuberous	JJ
cord-314109-wb45naw2	72	15	sclerosis	sclerosis	NN
cord-314109-wb45naw2	72	16	2	2	CD
cord-314109-wb45naw2	72	17	)	)	-RRB-
cord-314109-wb45naw2	73	1	(	(	-LRB-
cord-314109-wb45naw2	73	2	TSC1	TSC1	NNP
cord-314109-wb45naw2	73	3	/	/	SYM
cord-314109-wb45naw2	73	4	TSC2	TSC2	NNP
cord-314109-wb45naw2	73	5	)	)	-RRB-
cord-314109-wb45naw2	73	6	complex	complex	NN
cord-314109-wb45naw2	73	7	that	that	WDT
cord-314109-wb45naw2	73	8	blocks	block	VBZ
cord-314109-wb45naw2	73	9	mTORC1	mtorc1	CD
cord-314109-wb45naw2	73	10	activity	activity	NN
cord-314109-wb45naw2	73	11	[	[	-LRB-
cord-314109-wb45naw2	73	12	50	50	CD
cord-314109-wb45naw2	73	13	,	,	,
cord-314109-wb45naw2	73	14	51	51	CD
cord-314109-wb45naw2	73	15	]	]	-RRB-
cord-314109-wb45naw2	73	16	.	.	.
cord-314109-wb45naw2	74	1	Oversight	oversight	NN
cord-314109-wb45naw2	74	2	of	of	IN
cord-314109-wb45naw2	74	3	the	the	DT
cord-314109-wb45naw2	74	4	TSC1	TSC1	NNP
cord-314109-wb45naw2	74	5	/	/	SYM
cord-314109-wb45naw2	74	6	TSC2	TSC2	NNP
cord-314109-wb45naw2	74	7	complex	complex	NN
cord-314109-wb45naw2	74	8	also	also	RB
cord-314109-wb45naw2	74	9	is	be	VBZ
cord-314109-wb45naw2	74	10	controlled	control	VBN
cord-314109-wb45naw2	74	11	through	through	IN
cord-314109-wb45naw2	74	12	phosphoinositide	phosphoinositide	JJ
cord-314109-wb45naw2	74	13	3-kinase	3-kinase	CD
cord-314109-wb45naw2	74	14	(	(	-LRB-
cord-314109-wb45naw2	74	15	PI	PI	NNP
cord-314109-wb45naw2	74	16	3-K	3-K	NNP
cord-314109-wb45naw2	74	17	)	)	-RRB-
cord-314109-wb45naw2	74	18	,	,	,
cord-314109-wb45naw2	74	19	Akt	Akt	NNP
cord-314109-wb45naw2	74	20	,	,	,
cord-314109-wb45naw2	74	21	and	and	CC
cord-314109-wb45naw2	74	22	its	-PRON-	PRP$
cord-314109-wb45naw2	74	23	phosphorylation	phosphorylation	NN
cord-314109-wb45naw2	74	24	of	of	IN
cord-314109-wb45naw2	74	25	TSC2	TSC2	NNP
cord-314109-wb45naw2	74	26	.	.	.
cord-314109-wb45naw2	75	1	Extracellular	extracellular	JJ
cord-314109-wb45naw2	75	2	signal	signal	NN
cord-314109-wb45naw2	75	3	-	-	HYPH
cord-314109-wb45naw2	75	4	regulated	regulate	VBN
cord-314109-wb45naw2	75	5	kinases	kinase	NNS
cord-314109-wb45naw2	75	6	(	(	-LRB-
cord-314109-wb45naw2	75	7	ERKs	ERKs	NNP
cord-314109-wb45naw2	75	8	)	)	-RRB-
cord-314109-wb45naw2	75	9	,	,	,
cord-314109-wb45naw2	75	10	glycogen	glycogen	NN
cord-314109-wb45naw2	75	11	synthase	synthase	NN
cord-314109-wb45naw2	75	12	kinase	kinase	NN
cord-314109-wb45naw2	75	13	-3β	-3β	NN
cord-314109-wb45naw2	75	14	(	(	-LRB-
cord-314109-wb45naw2	75	15	GSK-3β	GSK-3β	NNP
cord-314109-wb45naw2	75	16	)	)	-RRB-
cord-314109-wb45naw2	75	17	,	,	,
cord-314109-wb45naw2	75	18	and	and	CC
cord-314109-wb45naw2	75	19	protein	protein	NN
cord-314109-wb45naw2	75	20	p90	p90	NN
cord-314109-wb45naw2	75	21	ribosomal	ribosomal	NN
cord-314109-wb45naw2	75	22	S6	S6	NNP
cord-314109-wb45naw2	75	23	kinase	kinase	NN
cord-314109-wb45naw2	75	24	1	1	CD
cord-314109-wb45naw2	76	1	(	(	-LRB-
cord-314109-wb45naw2	76	2	RSK1	RSK1	NNP
cord-314109-wb45naw2	76	3	)	)	-RRB-
cord-314109-wb45naw2	76	4	also	also	RB
cord-314109-wb45naw2	76	5	can	can	MD
cord-314109-wb45naw2	76	6	regulate	regulate	VB
cord-314109-wb45naw2	76	7	the	the	DT
cord-314109-wb45naw2	76	8	activity	activity	NN
cord-314109-wb45naw2	76	9	of	of	IN
cord-314109-wb45naw2	76	10	the	the	DT
cord-314109-wb45naw2	76	11	TSC1	TSC1	NNP
cord-314109-wb45naw2	76	12	/	/	SYM
cord-314109-wb45naw2	76	13	TSC2	TSC2	NNP
cord-314109-wb45naw2	76	14	complex	complex	NN
cord-314109-wb45naw2	76	15	.	.	.
cord-314109-wb45naw2	77	1	TSC2	TSC2	NNP
cord-314109-wb45naw2	77	2	acts	act	VBZ
cord-314109-wb45naw2	77	3	as	as	IN
cord-314109-wb45naw2	77	4	a	a	DT
cord-314109-wb45naw2	77	5	GTPase	GTPase	NNP
cord-314109-wb45naw2	77	6	-	-	HYPH
cord-314109-wb45naw2	77	7	activating	activate	VBG
cord-314109-wb45naw2	77	8	protein	protein	NN
cord-314109-wb45naw2	77	9	(	(	-LRB-
cord-314109-wb45naw2	77	10	GAP	gap	NN
cord-314109-wb45naw2	77	11	)	)	-RRB-
cord-314109-wb45naw2	77	12	that	that	WDT
cord-314109-wb45naw2	77	13	converts	convert	VBZ
cord-314109-wb45naw2	77	14	G	g	NN
cord-314109-wb45naw2	77	15	protein	protein	NN
cord-314109-wb45naw2	77	16	Rheb	Rheb	NNP
cord-314109-wb45naw2	77	17	(	(	-LRB-
cord-314109-wb45naw2	77	18	Rheb	Rheb	NNP
cord-314109-wb45naw2	77	19	-	-	HYPH
cord-314109-wb45naw2	77	20	GTP	GTP	NNP
cord-314109-wb45naw2	77	21	)	)	-RRB-
cord-314109-wb45naw2	77	22	into	into	IN
cord-314109-wb45naw2	77	23	the	the	DT
cord-314109-wb45naw2	77	24	inactive	inactive	JJ
cord-314109-wb45naw2	77	25	GDP	gdp	NN
cord-314109-wb45naw2	77	26	-	-	HYPH
cord-314109-wb45naw2	77	27	bound	bind	VBN
cord-314109-wb45naw2	77	28	form	form	NN
cord-314109-wb45naw2	77	29	(	(	-LRB-
cord-314109-wb45naw2	77	30	Rheb	Rheb	NNP
cord-314109-wb45naw2	77	31	-	-	HYPH
cord-314109-wb45naw2	77	32	GDP	GDP	NNP
cord-314109-wb45naw2	77	33	)	)	-RRB-
cord-314109-wb45naw2	77	34	.	.	.
cord-314109-wb45naw2	78	1	Once	once	IN
cord-314109-wb45naw2	78	2	Rheb	Rheb	NNP
cord-314109-wb45naw2	78	3	-	-	HYPH
cord-314109-wb45naw2	78	4	GTP	GTP	NNP
cord-314109-wb45naw2	78	5	becomes	become	VBZ
cord-314109-wb45naw2	78	6	active	active	JJ
cord-314109-wb45naw2	78	7	,	,	,
cord-314109-wb45naw2	78	8	Rheb	Rheb	NNP
cord-314109-wb45naw2	78	9	-	-	HYPH
cord-314109-wb45naw2	78	10	GTP	GTP	NNP
cord-314109-wb45naw2	78	11	associates	associate	NNS
cord-314109-wb45naw2	78	12	with	with	IN
cord-314109-wb45naw2	78	13	Raptor	Raptor	NNP
cord-314109-wb45naw2	78	14	to	to	TO
cord-314109-wb45naw2	78	15	control	control	VB
cord-314109-wb45naw2	78	16	4EBP1	4ebp1	CD
cord-314109-wb45naw2	78	17	and	and	CC
cord-314109-wb45naw2	78	18	mTORC1	mtorc1	NN
cord-314109-wb45naw2	78	19	binding	bind	VBG
cord-314109-wb45naw2	78	20	that	that	WDT
cord-314109-wb45naw2	78	21	increases	increase	VBZ
cord-314109-wb45naw2	78	22	mTORC1	mtorc1	CD
cord-314109-wb45naw2	78	23	activity	activity	NN
cord-314109-wb45naw2	78	24	[	[	-LRB-
cord-314109-wb45naw2	78	25	52	52	CD
cord-314109-wb45naw2	78	26	]	]	-RRB-
cord-314109-wb45naw2	78	27	.	.	.
cord-314109-wb45naw2	79	1	AMPK	AMPK	NNP
cord-314109-wb45naw2	79	2	phosphorylates	phosphorylate	VBZ
cord-314109-wb45naw2	79	3	TSC2	TSC2	NNP
cord-314109-wb45naw2	79	4	to	to	TO
cord-314109-wb45naw2	79	5	increase	increase	VB
cord-314109-wb45naw2	79	6	GAP	gap	NN
cord-314109-wb45naw2	79	7	activity	activity	NN
cord-314109-wb45naw2	79	8	to	to	TO
cord-314109-wb45naw2	79	9	change	change	VB
cord-314109-wb45naw2	79	10	Rheb	Rheb	NNP
cord-314109-wb45naw2	79	11	-	-	HYPH
cord-314109-wb45naw2	79	12	GTP	GTP	NNP
cord-314109-wb45naw2	79	13	into	into	IN
cord-314109-wb45naw2	79	14	the	the	DT
cord-314109-wb45naw2	79	15	inactive	inactive	JJ
cord-314109-wb45naw2	79	16	Rheb	Rheb	NNP
cord-314109-wb45naw2	79	17	-	-	HYPH
cord-314109-wb45naw2	79	18	GDP	GDP	NNP
cord-314109-wb45naw2	79	19	and	and	CC
cord-314109-wb45naw2	79	20	prevent	prevent	VB
cord-314109-wb45naw2	79	21	the	the	DT
cord-314109-wb45naw2	79	22	activity	activity	NN
cord-314109-wb45naw2	79	23	of	of	IN
cord-314109-wb45naw2	79	24	mTORC1	mTORC1	NNP
cord-314109-wb45naw2	79	25	[	[	-LRB-
cord-314109-wb45naw2	79	26	53	53	CD
cord-314109-wb45naw2	79	27	]	]	-RRB-
cord-314109-wb45naw2	79	28	.	.	.
cord-314109-wb45naw2	80	1	Considering	consider	VBG
cord-314109-wb45naw2	80	2	that	that	IN
cord-314109-wb45naw2	80	3	one	one	CD
cord-314109-wb45naw2	80	4	of	of	IN
cord-314109-wb45naw2	80	5	the	the	DT
cord-314109-wb45naw2	80	6	mechanisms	mechanism	NNS
cord-314109-wb45naw2	80	7	that	that	WDT
cord-314109-wb45naw2	80	8	can	can	MD
cord-314109-wb45naw2	80	9	lead	lead	VB
cord-314109-wb45naw2	80	10	to	to	IN
cord-314109-wb45naw2	80	11	severe	severe	JJ
cord-314109-wb45naw2	80	12	disability	disability	NN
cord-314109-wb45naw2	80	13	and	and	CC
cord-314109-wb45naw2	80	14	death	death	NN
cord-314109-wb45naw2	80	15	during	during	IN
cord-314109-wb45naw2	80	16	infection	infection	NN
cord-314109-wb45naw2	80	17	with	with	IN
cord-314109-wb45naw2	80	18	SARS	SARS	NNP
cord-314109-wb45naw2	80	19	-	-	HYPH
cord-314109-wb45naw2	80	20	CoV-2	CoV-2	NNP
cord-314109-wb45naw2	80	21	is	be	VBZ
cord-314109-wb45naw2	80	22	an	an	DT
cord-314109-wb45naw2	80	23	exaggerated	exaggerated	JJ
cord-314109-wb45naw2	80	24	activation	activation	NN
cord-314109-wb45naw2	80	25	of	of	IN
cord-314109-wb45naw2	80	26	the	the	DT
cord-314109-wb45naw2	80	27	host	host	NN
cord-314109-wb45naw2	80	28	's	's	POS
cord-314109-wb45naw2	80	29	immune	immune	JJ
cord-314109-wb45naw2	80	30	system	system	NN
cord-314109-wb45naw2	80	31	that	that	WDT
cord-314109-wb45naw2	80	32	results	result	VBZ
cord-314109-wb45naw2	80	33	in	in	IN
cord-314109-wb45naw2	80	34	systemic	systemic	JJ
cord-314109-wb45naw2	80	35	hyperinflammation	hyperinflammation	NN
cord-314109-wb45naw2	80	36	with	with	IN
cord-314109-wb45naw2	80	37	the	the	DT
cord-314109-wb45naw2	80	38	elevation	elevation	NN
cord-314109-wb45naw2	80	39	of	of	IN
cord-314109-wb45naw2	80	40	multiple	multiple	JJ
cord-314109-wb45naw2	80	41	pro	pro	JJ
cord-314109-wb45naw2	80	42	-	-	JJ
cord-314109-wb45naw2	80	43	inflammatory	inflammatory	JJ
cord-314109-wb45naw2	80	44	cytokines	cytokine	NNS
cord-314109-wb45naw2	80	45	,	,	,
cord-314109-wb45naw2	80	46	it	-PRON-	PRP
cord-314109-wb45naw2	80	47	is	be	VBZ
cord-314109-wb45naw2	80	48	interesting	interesting	JJ
cord-314109-wb45naw2	80	49	to	to	TO
cord-314109-wb45naw2	80	50	note	note	VB
cord-314109-wb45naw2	80	51	that	that	IN
cord-314109-wb45naw2	80	52	mTOR	mTOR	NNP
cord-314109-wb45naw2	80	53	pathways	pathway	NNS
cord-314109-wb45naw2	80	54	have	have	VBP
cord-314109-wb45naw2	80	55	been	be	VBN
cord-314109-wb45naw2	80	56	tied	tie	VBN
cord-314109-wb45naw2	80	57	to	to	IN
cord-314109-wb45naw2	80	58	immune	immune	JJ
cord-314109-wb45naw2	80	59	system	system	NN
cord-314109-wb45naw2	80	60	modulation	modulation	NN
cord-314109-wb45naw2	80	61	[	[	-LRB-
cord-314109-wb45naw2	80	62	40	40	CD
cord-314109-wb45naw2	80	63	,	,	,
cord-314109-wb45naw2	80	64	54	54	CD
cord-314109-wb45naw2	80	65	,	,	,
cord-314109-wb45naw2	80	66	55	55	CD
cord-314109-wb45naw2	80	67	]	]	-RRB-
cord-314109-wb45naw2	80	68	.	.	.
cord-314109-wb45naw2	81	1	Cytokine	cytokine	NN
cord-314109-wb45naw2	81	2	interleukin-37	interleukin-37	NNP
cord-314109-wb45naw2	81	3	(	(	-LRB-
cord-314109-wb45naw2	81	4	IL-37	IL-37	NNP
cord-314109-wb45naw2	81	5	)	)	-RRB-
cord-314109-wb45naw2	81	6	can	can	MD
cord-314109-wb45naw2	81	7	suppress	suppress	VB
cord-314109-wb45naw2	81	8	innate	innate	JJ
cord-314109-wb45naw2	81	9	and	and	CC
cord-314109-wb45naw2	81	10	acquired	acquire	VBN
cord-314109-wb45naw2	81	11	immune	immune	JJ
cord-314109-wb45naw2	81	12	responses	response	NNS
cord-314109-wb45naw2	81	13	.	.	.
cord-314109-wb45naw2	82	1	Recently	recently	RB
cord-314109-wb45naw2	82	2	it	-PRON-	PRP
cord-314109-wb45naw2	82	3	has	have	VBZ
cord-314109-wb45naw2	82	4	been	be	VBN
cord-314109-wb45naw2	82	5	observed	observe	VBN
cord-314109-wb45naw2	82	6	that	that	IN
cord-314109-wb45naw2	82	7	IL-37	IL-37	NNP
cord-314109-wb45naw2	82	8	during	during	IN
cord-314109-wb45naw2	82	9	COVID-19	covid-19	JJ
cord-314109-wb45naw2	82	10	infection	infection	NN
cord-314109-wb45naw2	82	11	is	be	VBZ
cord-314109-wb45naw2	82	12	immunosuppressive	immunosuppressive	JJ
cord-314109-wb45naw2	82	13	through	through	IN
cord-314109-wb45naw2	82	14	mTOR	mTOR	NNP
cord-314109-wb45naw2	82	15	and	and	CC
cord-314109-wb45naw2	82	16	can	can	MD
cord-314109-wb45naw2	82	17	increase	increase	VB
cord-314109-wb45naw2	82	18	the	the	DT
cord-314109-wb45naw2	82	19	activity	activity	NN
cord-314109-wb45naw2	82	20	of	of	IN
cord-314109-wb45naw2	82	21	AMPK	AMPK	NNP
cord-314109-wb45naw2	82	22	[	[	-LRB-
cord-314109-wb45naw2	82	23	7	7	CD
cord-314109-wb45naw2	82	24	]	]	-RRB-
cord-314109-wb45naw2	82	25	.	.	.
cord-314109-wb45naw2	83	1	IL-37	IL-37	NNP
cord-314109-wb45naw2	83	2	inhibits	inhibit	VBZ
cord-314109-wb45naw2	83	3	class	class	NN
cord-314109-wb45naw2	83	4	II	ii	NN
cord-314109-wb45naw2	83	5	histocompatibility	histocompatibility	NN
cord-314109-wb45naw2	83	6	complex	complex	NN
cord-314109-wb45naw2	83	7	(	(	-LRB-
cord-314109-wb45naw2	83	8	MHC	MHC	NNP
cord-314109-wb45naw2	83	9	)	)	-RRB-
cord-314109-wb45naw2	83	10	molecules	molecule	NNS
cord-314109-wb45naw2	83	11	and	and	CC
cord-314109-wb45naw2	83	12	inflammation	inflammation	NN
cord-314109-wb45naw2	83	13	by	by	IN
cord-314109-wb45naw2	83	14	blocking	block	VBG
cord-314109-wb45naw2	83	15	IL-1beta	il-1beta	NN
cord-314109-wb45naw2	83	16	,	,	,
cord-314109-wb45naw2	83	17	IL-6	IL-6	NNP
cord-314109-wb45naw2	83	18	,	,	,
cord-314109-wb45naw2	83	19	TNF	TNF	NNP
cord-314109-wb45naw2	83	20	and	and	CC
cord-314109-wb45naw2	83	21	chemokine	chemokine	NN
cord-314109-wb45naw2	83	22	(	(	-LRB-
cord-314109-wb45naw2	83	23	C	C	NNP
cord-314109-wb45naw2	83	24	-	-	HYPH
cord-314109-wb45naw2	83	25	C	C	NNP
cord-314109-wb45naw2	83	26	motif	motif	NN
cord-314109-wb45naw2	83	27	)	)	-RRB-
cord-314109-wb45naw2	83	28	ligand	ligand	NN
cord-314109-wb45naw2	83	29	(	(	-LRB-
cord-314109-wb45naw2	83	30	CCL	CCL	NNP
cord-314109-wb45naw2	83	31	)	)	-RRB-
cord-314109-wb45naw2	83	32	.	.	.
cord-314109-wb45naw2	84	1	As	as	IN
cord-314109-wb45naw2	84	2	a	a	DT
cord-314109-wb45naw2	84	3	result	result	NN
cord-314109-wb45naw2	84	4	,	,	,
cord-314109-wb45naw2	84	5	IL-37	IL-37	NNP
cord-314109-wb45naw2	84	6	with	with	IN
cord-314109-wb45naw2	84	7	its	-PRON-	PRP$
cord-314109-wb45naw2	84	8	ability	ability	NN
cord-314109-wb45naw2	84	9	to	to	TO
cord-314109-wb45naw2	84	10	modulate	modulate	VB
cord-314109-wb45naw2	84	11	mTOR	mTOR	NNP
cord-314109-wb45naw2	84	12	and	and	CC
cord-314109-wb45naw2	84	13	AMPK	AMPK	NNP
cord-314109-wb45naw2	84	14	could	could	MD
cord-314109-wb45naw2	84	15	be	be	VB
cord-314109-wb45naw2	84	16	considered	consider	VBN
cord-314109-wb45naw2	84	17	as	as	IN
cord-314109-wb45naw2	84	18	a	a	DT
cord-314109-wb45naw2	84	19	new	new	JJ
cord-314109-wb45naw2	84	20	target	target	NN
cord-314109-wb45naw2	84	21	to	to	TO
cord-314109-wb45naw2	84	22	control	control	VB
cord-314109-wb45naw2	84	23	hyperinflammation	hyperinflammation	NN
cord-314109-wb45naw2	84	24	during	during	IN
cord-314109-wb45naw2	84	25	viral	viral	JJ
cord-314109-wb45naw2	84	26	infections	infection	NNS
cord-314109-wb45naw2	84	27	that	that	WDT
cord-314109-wb45naw2	84	28	include	include	VBP
cord-314109-wb45naw2	84	29	SARS	SARS	NNP
cord-314109-wb45naw2	84	30	-	-	HYPH
cord-314109-wb45naw2	84	31	CoV-2	CoV-2	NNP
cord-314109-wb45naw2	84	32	.	.	.
cord-314109-wb45naw2	85	1	In	in	IN
cord-314109-wb45naw2	85	2	addition	addition	NN
cord-314109-wb45naw2	85	3	,	,	,
cord-314109-wb45naw2	85	4	other	other	JJ
cord-314109-wb45naw2	85	5	studies	study	NNS
cord-314109-wb45naw2	85	6	support	support	VBP
cord-314109-wb45naw2	85	7	the	the	DT
cord-314109-wb45naw2	85	8	premise	premise	NN
cord-314109-wb45naw2	85	9	that	that	IN
cord-314109-wb45naw2	85	10	AMPK	AMPK	NNP
cord-314109-wb45naw2	85	11	activation	activation	NN
cord-314109-wb45naw2	85	12	can	can	MD
cord-314109-wb45naw2	85	13	regulate	regulate	VB
cord-314109-wb45naw2	85	14	immune	immune	JJ
cord-314109-wb45naw2	85	15	system	system	NN
cord-314109-wb45naw2	85	16	activation	activation	NN
cord-314109-wb45naw2	85	17	.	.	.
cord-314109-wb45naw2	86	1	During	during	IN
cord-314109-wb45naw2	86	2	periods	period	NNS
cord-314109-wb45naw2	86	3	of	of	IN
cord-314109-wb45naw2	86	4	hyperglycemia	hyperglycemia	NN
cord-314109-wb45naw2	86	5	,	,	,
cord-314109-wb45naw2	86	6	AMPK	AMPK	NNP
cord-314109-wb45naw2	86	7	activation	activation	NN
cord-314109-wb45naw2	86	8	with	with	IN
cord-314109-wb45naw2	86	9	mTOR	mTOR	NNP
cord-314109-wb45naw2	86	10	inhibition	inhibition	NN
cord-314109-wb45naw2	86	11	has	have	VBZ
cord-314109-wb45naw2	86	12	been	be	VBN
cord-314109-wb45naw2	86	13	shown	show	VBN
cord-314109-wb45naw2	86	14	to	to	TO
cord-314109-wb45naw2	86	15	prevent	prevent	VB
cord-314109-wb45naw2	86	16	cell	cell	NN
cord-314109-wb45naw2	86	17	injury	injury	NN
cord-314109-wb45naw2	86	18	with	with	IN
cord-314109-wb45naw2	86	19	the	the	DT
cord-314109-wb45naw2	86	20	reduction	reduction	NN
cord-314109-wb45naw2	86	21	of	of	IN
cord-314109-wb45naw2	86	22	adhesion	adhesion	NN
cord-314109-wb45naw2	86	23	molecules	molecule	NNS
cord-314109-wb45naw2	86	24	[	[	-LRB-
cord-314109-wb45naw2	86	25	41	41	CD
cord-314109-wb45naw2	86	26	]	]	-RRB-
cord-314109-wb45naw2	86	27	.	.	.
cord-314109-wb45naw2	87	1	However	however	RB
cord-314109-wb45naw2	87	2	,	,	,
cord-314109-wb45naw2	87	3	in	in	IN
cord-314109-wb45naw2	87	4	some	some	DT
cord-314109-wb45naw2	87	5	cases	case	NNS
cord-314109-wb45naw2	87	6	activation	activation	NN
cord-314109-wb45naw2	87	7	of	of	IN
cord-314109-wb45naw2	87	8	mTOR	mTOR	NNP
cord-314109-wb45naw2	87	9	also	also	RB
cord-314109-wb45naw2	87	10	may	may	MD
cord-314109-wb45naw2	87	11	play	play	VB
cord-314109-wb45naw2	87	12	a	a	DT
cord-314109-wb45naw2	87	13	role	role	NN
cord-314109-wb45naw2	87	14	in	in	IN
cord-314109-wb45naw2	87	15	anti	anti	JJ
cord-314109-wb45naw2	87	16	-	-	JJ
cord-314109-wb45naw2	87	17	inflammatory	inflammatory	JJ
cord-314109-wb45naw2	87	18	mechanisms	mechanism	NNS
cord-314109-wb45naw2	87	19	to	to	TO
cord-314109-wb45naw2	87	20	limit	limit	VB
cord-314109-wb45naw2	87	21	the	the	DT
cord-314109-wb45naw2	87	22	toxic	toxic	JJ
cord-314109-wb45naw2	87	23	effects	effect	NNS
cord-314109-wb45naw2	87	24	of	of	IN
cord-314109-wb45naw2	87	25	reactive	reactive	JJ
cord-314109-wb45naw2	87	26	oxygen	oxygen	NN
cord-314109-wb45naw2	87	27	species	specie	NNS
cord-314109-wb45naw2	87	28	and	and	CC
cord-314109-wb45naw2	87	29	maintain	maintain	VB
cord-314109-wb45naw2	87	30	mitochondrial	mitochondrial	JJ
cord-314109-wb45naw2	87	31	membrane	membrane	NN
cord-314109-wb45naw2	87	32	potential	potential	NN
cord-314109-wb45naw2	87	33	to	to	TO
cord-314109-wb45naw2	87	34	prevent	prevent	VB
cord-314109-wb45naw2	87	35	cell	cell	NN
cord-314109-wb45naw2	87	36	injury	injury	NN
cord-314109-wb45naw2	87	37	[	[	-LRB-
cord-314109-wb45naw2	87	38	56	56	CD
cord-314109-wb45naw2	87	39	]	]	-RRB-
cord-314109-wb45naw2	87	40	.	.	.
cord-314109-wb45naw2	88	1	In	in	IN
cord-314109-wb45naw2	88	2	studies	study	NNS
cord-314109-wb45naw2	88	3	involving	involve	VBG
cord-314109-wb45naw2	88	4	the	the	DT
cord-314109-wb45naw2	88	5	exposure	exposure	NN
cord-314109-wb45naw2	88	6	to	to	IN
cord-314109-wb45naw2	88	7	oxidative	oxidative	JJ
cord-314109-wb45naw2	88	8	stress	stress	NN
cord-314109-wb45naw2	88	9	,	,	,
cord-314109-wb45naw2	88	10	mTORC1	mTORC1	NNP
cord-314109-wb45naw2	88	11	and	and	CC
cord-314109-wb45naw2	88	12	mTORC2	mTORC2	NNP
cord-314109-wb45naw2	88	13	activation	activation	NN
cord-314109-wb45naw2	88	14	has	have	VBZ
cord-314109-wb45naw2	88	15	resulted	result	VBN
cord-314109-wb45naw2	88	16	in	in	IN
cord-314109-wb45naw2	88	17	the	the	DT
cord-314109-wb45naw2	88	18	production	production	NN
cord-314109-wb45naw2	88	19	of	of	IN
cord-314109-wb45naw2	88	20	the	the	DT
cord-314109-wb45naw2	88	21	anti	anti	JJ
cord-314109-wb45naw2	88	22	-	-	JJ
cord-314109-wb45naw2	88	23	inflammatory	inflammatory	JJ
cord-314109-wb45naw2	88	24	cytokine	cytokine	NN
cord-314109-wb45naw2	88	25	IL-10	IL-10	NNP
cord-314109-wb45naw2	88	26	to	to	TO
cord-314109-wb45naw2	88	27	prevent	prevent	VB
cord-314109-wb45naw2	88	28	apoptotic	apoptotic	JJ
cord-314109-wb45naw2	88	29	cell	cell	NN
cord-314109-wb45naw2	88	30	death	death	NN
cord-314109-wb45naw2	88	31	[	[	-LRB-
cord-314109-wb45naw2	88	32	57	57	CD
cord-314109-wb45naw2	88	33	]	]	-RRB-
cord-314109-wb45naw2	88	34	.	.	.
cord-314109-wb45naw2	89	1	In	in	IN
cord-314109-wb45naw2	89	2	addition	addition	NN
cord-314109-wb45naw2	89	3	,	,	,
cord-314109-wb45naw2	89	4	mTOR	mTOR	NNP
cord-314109-wb45naw2	89	5	activation	activation	NN
cord-314109-wb45naw2	89	6	can	can	MD
cord-314109-wb45naw2	89	7	block	block	VB
cord-314109-wb45naw2	89	8	the	the	DT
cord-314109-wb45naw2	89	9	pro	pro	JJ
cord-314109-wb45naw2	89	10	-	-	JJ
cord-314109-wb45naw2	89	11	inflammatory	inflammatory	JJ
cord-314109-wb45naw2	89	12	cytokine	cytokine	NN
cord-314109-wb45naw2	89	13	TNF	tnf	NN
cord-314109-wb45naw2	89	14	-	-	HYPH
cord-314109-wb45naw2	89	15	α	α	NNP
cord-314109-wb45naw2	89	16	and	and	CC
cord-314109-wb45naw2	89	17	foster	foster	JJ
cord-314109-wb45naw2	89	18	antiinflammatory	antiinflammatory	JJ
cord-314109-wb45naw2	89	19	cytokine	cytokine	NN
cord-314109-wb45naw2	89	20	IL-10	IL-10	NNP
cord-314109-wb45naw2	89	21	activity	activity	NN
cord-314109-wb45naw2	89	22	[	[	-LRB-
cord-314109-wb45naw2	89	23	58	58	CD
cord-314109-wb45naw2	89	24	]	]	-RRB-
cord-314109-wb45naw2	89	25	.	.	.
cord-314109-wb45naw2	90	1	Agents	agent	NNS
cord-314109-wb45naw2	90	2	,	,	,
cord-314109-wb45naw2	90	3	such	such	JJ
cord-314109-wb45naw2	90	4	as	as	IN
cord-314109-wb45naw2	90	5	metformin	metformin	NNP
cord-314109-wb45naw2	90	6	,	,	,
cord-314109-wb45naw2	90	7	used	use	VBN
cord-314109-wb45naw2	90	8	for	for	IN
cord-314109-wb45naw2	90	9	the	the	DT
cord-314109-wb45naw2	90	10	treatment	treatment	NN
cord-314109-wb45naw2	90	11	of	of	IN
cord-314109-wb45naw2	90	12	DM	DM	NNP
cord-314109-wb45naw2	90	13	also	also	RB
cord-314109-wb45naw2	90	14	may	may	MD
cord-314109-wb45naw2	90	15	be	be	VB
cord-314109-wb45naw2	90	16	repurposed	repurpose	VBN
cord-314109-wb45naw2	90	17	for	for	IN
cord-314109-wb45naw2	90	18	potential	potential	JJ
cord-314109-wb45naw2	90	19	antiviral	antiviral	JJ
cord-314109-wb45naw2	90	20	activity	activity	NN
cord-314109-wb45naw2	90	21	.	.	.
cord-314109-wb45naw2	91	1	Considerations	consideration	NNS
cord-314109-wb45naw2	91	2	for	for	IN
cord-314109-wb45naw2	91	3	metformin	metformin	NNP
cord-314109-wb45naw2	91	4	become	become	VBN
cord-314109-wb45naw2	91	5	relevant	relevant	JJ
cord-314109-wb45naw2	91	6	since	since	IN
cord-314109-wb45naw2	91	7	metformin	metformin	NNP
cord-314109-wb45naw2	91	8	oversees	oversee	VBZ
cord-314109-wb45naw2	91	9	mTOR	mTOR	NNP
cord-314109-wb45naw2	91	10	activity	activity	NN
cord-314109-wb45naw2	91	11	and	and	CC
cord-314109-wb45naw2	91	12	it	-PRON-	PRP
cord-314109-wb45naw2	91	13	has	have	VBZ
cord-314109-wb45naw2	91	14	become	become	VBN
cord-314109-wb45naw2	91	15	evident	evident	JJ
cord-314109-wb45naw2	91	16	that	that	IN
cord-314109-wb45naw2	91	17	individuals	individual	NNS
cord-314109-wb45naw2	91	18	with	with	IN
cord-314109-wb45naw2	91	19	co	co	NNS
cord-314109-wb45naw2	91	20	-	-	NNS
cord-314109-wb45naw2	91	21	morbidities	morbidity	NNS
cord-314109-wb45naw2	91	22	with	with	IN
cord-314109-wb45naw2	91	23	DM	DM	NNP
cord-314109-wb45naw2	91	24	have	have	VBP
cord-314109-wb45naw2	91	25	increased	increase	VBN
cord-314109-wb45naw2	91	26	risk	risk	NN
cord-314109-wb45naw2	91	27	for	for	IN
cord-314109-wb45naw2	91	28	developing	develop	VBG
cord-314109-wb45naw2	91	29	severe	severe	JJ
cord-314109-wb45naw2	91	30	illness	illness	NN
cord-314109-wb45naw2	91	31	with	with	IN
cord-314109-wb45naw2	91	32	COVID-19	COVID-19	NNP
cord-314109-wb45naw2	91	33	[	[	-LRB-
cord-314109-wb45naw2	91	34	8	8	CD
cord-314109-wb45naw2	91	35	]	]	-RRB-
cord-314109-wb45naw2	91	36	.	.	.
cord-314109-wb45naw2	92	1	Metformin	Metformin	NNP
cord-314109-wb45naw2	92	2	relies	rely	VBZ
cord-314109-wb45naw2	92	3	upon	upon	IN
cord-314109-wb45naw2	92	4	the	the	DT
cord-314109-wb45naw2	92	5	modulation	modulation	NN
cord-314109-wb45naw2	92	6	of	of	IN
cord-314109-wb45naw2	92	7	mTOR	mtor	NN
cord-314109-wb45naw2	92	8	and	and	CC
cord-314109-wb45naw2	92	9	AMPK	AMPK	NNP
cord-314109-wb45naw2	92	10	to	to	TO
cord-314109-wb45naw2	92	11	oversee	oversee	VB
cord-314109-wb45naw2	92	12	cellular	cellular	JJ
cord-314109-wb45naw2	92	13	survival	survival	NN
cord-314109-wb45naw2	92	14	[	[	-LRB-
cord-314109-wb45naw2	92	15	49	49	CD
cord-314109-wb45naw2	92	16	,	,	,
cord-314109-wb45naw2	92	17	59	59	CD
cord-314109-wb45naw2	92	18	]	]	-RRB-
cord-314109-wb45naw2	92	19	.	.	.
cord-314109-wb45naw2	93	1	Metformin	Metformin	NNP
cord-314109-wb45naw2	93	2	can	can	MD
cord-314109-wb45naw2	93	3	block	block	VB
cord-314109-wb45naw2	93	4	mTOR	mtor	NN
cord-314109-wb45naw2	93	5	activity	activity	NN
cord-314109-wb45naw2	93	6	,	,	,
cord-314109-wb45naw2	93	7	promote	promote	VB
cord-314109-wb45naw2	93	8	autophagy	autophagy	NN
cord-314109-wb45naw2	93	9	[	[	-LRB-
cord-314109-wb45naw2	93	10	60	60	CD
cord-314109-wb45naw2	93	11	,	,	,
cord-314109-wb45naw2	93	12	61	61	CD
cord-314109-wb45naw2	93	13	]	]	-RRB-
cord-314109-wb45naw2	93	14	,	,	,
cord-314109-wb45naw2	93	15	and	and	CC
cord-314109-wb45naw2	93	16	may	may	MD
cord-314109-wb45naw2	93	17	function	function	VB
cord-314109-wb45naw2	93	18	in	in	IN
cord-314109-wb45naw2	93	19	an	an	DT
cord-314109-wb45naw2	93	20	AMPK	AMPK	NNP
cord-314109-wb45naw2	93	21	-	-	HYPH
cord-314109-wb45naw2	93	22	independent	independent	JJ
cord-314109-wb45naw2	93	23	manner	manner	NN
cord-314109-wb45naw2	93	24	[	[	-LRB-
cord-314109-wb45naw2	93	25	62	62	CD
cord-314109-wb45naw2	93	26	]	]	-RRB-
cord-314109-wb45naw2	93	27	.	.	.
cord-314109-wb45naw2	94	1	Yet	yet	RB
cord-314109-wb45naw2	94	2	,	,	,
cord-314109-wb45naw2	94	3	additional	additional	JJ
cord-314109-wb45naw2	94	4	studies	study	NNS
cord-314109-wb45naw2	94	5	show	show	VBP
cord-314109-wb45naw2	94	6	that	that	IN
cord-314109-wb45naw2	94	7	metformin	metformin	NNP
cord-314109-wb45naw2	94	8	can	can	MD
cord-314109-wb45naw2	94	9	activate	activate	VB
cord-314109-wb45naw2	94	10	AMPK	AMPK	NNP
cord-314109-wb45naw2	94	11	,	,	,
cord-314109-wb45naw2	94	12	lead	lead	VB
cord-314109-wb45naw2	94	13	to	to	IN
cord-314109-wb45naw2	94	14	autophagy	autophagy	NN
cord-314109-wb45naw2	94	15	induction	induction	NN
cord-314109-wb45naw2	94	16	,	,	,
cord-314109-wb45naw2	94	17	and	and	CC
cord-314109-wb45naw2	94	18	protect	protect	VB
cord-314109-wb45naw2	94	19	against	against	IN
cord-314109-wb45naw2	94	20	cell	cell	NN
cord-314109-wb45naw2	94	21	apoptosis	apoptosis	NN
cord-314109-wb45naw2	94	22	[	[	-LRB-
cord-314109-wb45naw2	94	23	63	63	CD
cord-314109-wb45naw2	94	24	]	]	-RRB-
cord-314109-wb45naw2	94	25	.	.	.
cord-314109-wb45naw2	95	1	Metformin	Metformin	NNP
cord-314109-wb45naw2	95	2	also	also	RB
cord-314109-wb45naw2	95	3	has	have	VBZ
cord-314109-wb45naw2	95	4	been	be	VBN
cord-314109-wb45naw2	95	5	shown	show	VBN
cord-314109-wb45naw2	95	6	to	to	TO
cord-314109-wb45naw2	95	7	limit	limit	VB
cord-314109-wb45naw2	95	8	lipid	lipid	NN
cord-314109-wb45naw2	95	9	peroxidation	peroxidation	NN
cord-314109-wb45naw2	95	10	in	in	IN
cord-314109-wb45naw2	95	11	the	the	DT
cord-314109-wb45naw2	95	12	brain	brain	NN
cord-314109-wb45naw2	95	13	and	and	CC
cord-314109-wb45naw2	95	14	spinal	spinal	JJ
cord-314109-wb45naw2	95	15	cord	cord	NN
cord-314109-wb45naw2	95	16	and	and	CC
cord-314109-wb45naw2	95	17	decrease	decrease	NN
cord-314109-wb45naw2	95	18	caspase	caspase	NN
cord-314109-wb45naw2	95	19	activity	activity	NN
cord-314109-wb45naw2	95	20	during	during	IN
cord-314109-wb45naw2	95	21	toxic	toxic	JJ
cord-314109-wb45naw2	95	22	insults	insult	NNS
cord-314109-wb45naw2	95	23	that	that	WDT
cord-314109-wb45naw2	95	24	can	can	MD
cord-314109-wb45naw2	95	25	lead	lead	VB
cord-314109-wb45naw2	95	26	to	to	IN
cord-314109-wb45naw2	95	27	excessive	excessive	JJ
cord-314109-wb45naw2	95	28	inflammatory	inflammatory	JJ
cord-314109-wb45naw2	95	29	cell	cell	NN
cord-314109-wb45naw2	95	30	activation	activation	NN
cord-314109-wb45naw2	95	31	[	[	-LRB-
cord-314109-wb45naw2	95	32	49	49	CD
cord-314109-wb45naw2	95	33	,	,	,
cord-314109-wb45naw2	95	34	64	64	CD
cord-314109-wb45naw2	95	35	]	]	-RRB-
cord-314109-wb45naw2	95	36	.	.	.
cord-314109-wb45naw2	96	1	Recently	recently	RB
cord-314109-wb45naw2	96	2	,	,	,
cord-314109-wb45naw2	96	3	the	the	DT
cord-314109-wb45naw2	96	4	agent	agent	NN
cord-314109-wb45naw2	96	5	hydroxychloroquine	hydroxychloroquine	NN
cord-314109-wb45naw2	96	6	when	when	WRB
cord-314109-wb45naw2	96	7	used	use	VBN
cord-314109-wb45naw2	96	8	as	as	IN
cord-314109-wb45naw2	96	9	adjuvant	adjuvant	NN
cord-314109-wb45naw2	96	10	therapy	therapy	NN
cord-314109-wb45naw2	96	11	with	with	IN
cord-314109-wb45naw2	96	12	metformin	metformin	NNP
cord-314109-wb45naw2	96	13	has	have	VBZ
cord-314109-wb45naw2	96	14	been	be	VBN
cord-314109-wb45naw2	96	15	shown	show	VBN
cord-314109-wb45naw2	96	16	to	to	TO
cord-314109-wb45naw2	96	17	have	have	VB
cord-314109-wb45naw2	96	18	protective	protective	JJ
cord-314109-wb45naw2	96	19	cellular	cellular	JJ
cord-314109-wb45naw2	96	20	effects	effect	NNS
cord-314109-wb45naw2	96	21	in	in	IN
cord-314109-wb45naw2	96	22	patients	patient	NNS
cord-314109-wb45naw2	96	23	with	with	IN
cord-314109-wb45naw2	96	24	DM	DM	NNP
cord-314109-wb45naw2	96	25	by	by	IN
cord-314109-wb45naw2	96	26	improving	improve	VBG
cord-314109-wb45naw2	96	27	glycemic	glycemic	JJ
cord-314109-wb45naw2	96	28	control	control	NN
cord-314109-wb45naw2	96	29	[	[	-LRB-
cord-314109-wb45naw2	96	30	65	65	CD
cord-314109-wb45naw2	96	31	]	]	-RRB-
cord-314109-wb45naw2	96	32	,	,	,
cord-314109-wb45naw2	96	33	suggesting	suggest	VBG
cord-314109-wb45naw2	96	34	that	that	IN
cord-314109-wb45naw2	96	35	either	either	DT
cord-314109-wb45naw2	96	36	of	of	IN
cord-314109-wb45naw2	96	37	these	these	DT
cord-314109-wb45naw2	96	38	agents	agent	NNS
cord-314109-wb45naw2	96	39	may	may	MD
cord-314109-wb45naw2	96	40	have	have	VB
cord-314109-wb45naw2	96	41	some	some	DT
cord-314109-wb45naw2	96	42	role	role	NN
cord-314109-wb45naw2	96	43	for	for	IN
cord-314109-wb45naw2	96	44	antiviral	antiviral	JJ
cord-314109-wb45naw2	96	45	treatments	treatment	NNS
cord-314109-wb45naw2	96	46	.	.	.
cord-314109-wb45naw2	97	1	Several	several	JJ
cord-314109-wb45naw2	97	2	clinical	clinical	JJ
cord-314109-wb45naw2	97	3	studies	study	NNS
cord-314109-wb45naw2	97	4	registered	register	VBN
cord-314109-wb45naw2	97	5	on	on	IN
cord-314109-wb45naw2	97	6	the	the	DT
cord-314109-wb45naw2	97	7	United	United	NNP
cord-314109-wb45naw2	97	8	States	States	NNP
cord-314109-wb45naw2	97	9	National	National	NNP
cord-314109-wb45naw2	97	10	Library	Library	NNP
cord-314109-wb45naw2	97	11	of	of	IN
cord-314109-wb45naw2	97	12	Medicine	Medicine	NNP
cord-314109-wb45naw2	97	13	website	website	NN
cord-314109-wb45naw2	97	14	ClinicalTrials.gov	ClinicalTrials.gov	NNP
cord-314109-wb45naw2	97	15	are	be	VBP
cord-314109-wb45naw2	97	16	now	now	RB
cord-314109-wb45naw2	97	17	in	in	IN
cord-314109-wb45naw2	97	18	preparation	preparation	NN
cord-314109-wb45naw2	97	19	or	or	CC
cord-314109-wb45naw2	97	20	actively	actively	RB
cord-314109-wb45naw2	97	21	recruiting	recruit	VBG
cord-314109-wb45naw2	97	22	patients	patient	NNS
cord-314109-wb45naw2	97	23	to	to	TO
cord-314109-wb45naw2	97	24	examine	examine	VB
cord-314109-wb45naw2	97	25	both	both	CC
cord-314109-wb45naw2	97	26	the	the	DT
cord-314109-wb45naw2	97	27	safety	safety	NN
cord-314109-wb45naw2	97	28	and	and	CC
cord-314109-wb45naw2	97	29	efficacy	efficacy	NN
cord-314109-wb45naw2	97	30	of	of	IN
cord-314109-wb45naw2	97	31	hydroxychloroquine	hydroxychloroquine	NNP
cord-314109-wb45naw2	97	32	administration	administration	NNP
cord-314109-wb45naw2	97	33	in	in	IN
cord-314109-wb45naw2	97	34	individuals	individual	NNS
cord-314109-wb45naw2	97	35	as	as	IN
cord-314109-wb45naw2	97	36	an	an	DT
cord-314109-wb45naw2	97	37	antiviral	antiviral	JJ
cord-314109-wb45naw2	97	38	treatment	treatment	NN
cord-314109-wb45naw2	97	39	such	such	JJ
cord-314109-wb45naw2	97	40	as	as	IN
cord-314109-wb45naw2	97	41	for	for	IN
cord-314109-wb45naw2	97	42	COVID-19	COVID-19	NNP
cord-314109-wb45naw2	97	43	.	.	.
cord-314109-wb45naw2	98	1	mTOR	mTOR	NNP
cord-314109-wb45naw2	98	2	has	have	VBZ
cord-314109-wb45naw2	98	3	not	not	RB
cord-314109-wb45naw2	98	4	only	only	RB
cord-314109-wb45naw2	98	5	been	be	VBN
cord-314109-wb45naw2	98	6	shown	show	VBN
cord-314109-wb45naw2	98	7	to	to	TO
cord-314109-wb45naw2	98	8	be	be	VB
cord-314109-wb45naw2	98	9	important	important	JJ
cord-314109-wb45naw2	98	10	for	for	IN
cord-314109-wb45naw2	98	11	immune	immune	JJ
cord-314109-wb45naw2	98	12	system	system	NN
cord-314109-wb45naw2	98	13	regulation	regulation	NN
cord-314109-wb45naw2	98	14	,	,	,
cord-314109-wb45naw2	98	15	but	but	CC
cord-314109-wb45naw2	98	16	studies	study	NNS
cord-314109-wb45naw2	98	17	have	have	VBP
cord-314109-wb45naw2	98	18	shown	show	VBN
cord-314109-wb45naw2	98	19	that	that	IN
cord-314109-wb45naw2	98	20	mTOR	mTOR	NNP
cord-314109-wb45naw2	98	21	also	also	RB
cord-314109-wb45naw2	98	22	can	can	MD
cord-314109-wb45naw2	98	23	regulate	regulate	VB
cord-314109-wb45naw2	98	24	viral	viral	JJ
cord-314109-wb45naw2	98	25	infection	infection	NN
cord-314109-wb45naw2	98	26	activity	activity	NN
cord-314109-wb45naw2	98	27	.	.	.
cord-314109-wb45naw2	99	1	In	in	IN
cord-314109-wb45naw2	99	2	regards	regard	NNS
cord-314109-wb45naw2	99	3	to	to	IN
cord-314109-wb45naw2	99	4	the	the	DT
cord-314109-wb45naw2	99	5	West	West	NNP
cord-314109-wb45naw2	99	6	Nile	Nile	NNP
cord-314109-wb45naw2	99	7	virus	virus	NN
cord-314109-wb45naw2	99	8	,	,	,
cord-314109-wb45naw2	99	9	growth	growth	NN
cord-314109-wb45naw2	99	10	of	of	IN
cord-314109-wb45naw2	99	11	this	this	DT
cord-314109-wb45naw2	99	12	virion	virion	NN
cord-314109-wb45naw2	99	13	and	and	CC
cord-314109-wb45naw2	99	14	its	-PRON-	PRP$
cord-314109-wb45naw2	99	15	expression	expression	NN
cord-314109-wb45naw2	99	16	are	be	VBP
cord-314109-wb45naw2	99	17	dependent	dependent	JJ
cord-314109-wb45naw2	99	18	upon	upon	IN
cord-314109-wb45naw2	99	19	mTORC1	mTORC1	NNP
cord-314109-wb45naw2	99	20	mediated	mediate	VBN
cord-314109-wb45naw2	99	21	-	-	HYPH
cord-314109-wb45naw2	99	22	regulation	regulation	NN
cord-314109-wb45naw2	99	23	of	of	IN
cord-314109-wb45naw2	99	24	4EBP/	4ebp/	CD
cord-314109-wb45naw2	99	25	eIF4E	eif4e	CD
cord-314109-wb45naw2	99	26	interaction	interaction	NN
cord-314109-wb45naw2	99	27	and	and	CC
cord-314109-wb45naw2	99	28	eukaryotic	eukaryotic	JJ
cord-314109-wb45naw2	99	29	initiation	initiation	NN
cord-314109-wb45naw2	99	30	factor	factor	NN
cord-314109-wb45naw2	99	31	4F	4F	NNP
cord-314109-wb45naw2	99	32	(	(	-LRB-
cord-314109-wb45naw2	99	33	eIF4F	eif4f	CD
cord-314109-wb45naw2	99	34	]	]	-RRB-
cord-314109-wb45naw2	100	1	complex	complex	JJ
cord-314109-wb45naw2	100	2	formation	formation	NN
cord-314109-wb45naw2	100	3	to	to	TO
cord-314109-wb45naw2	100	4	support	support	VB
cord-314109-wb45naw2	100	5	viral	viral	JJ
cord-314109-wb45naw2	100	6	growth	growth	NN
cord-314109-wb45naw2	100	7	[	[	-LRB-
cord-314109-wb45naw2	100	8	66	66	CD
cord-314109-wb45naw2	100	9	]	]	-RRB-
cord-314109-wb45naw2	100	10	.	.	.
cord-314109-wb45naw2	101	1	Yet	yet	RB
cord-314109-wb45naw2	101	2	,	,	,
cord-314109-wb45naw2	101	3	the	the	DT
cord-314109-wb45naw2	101	4	role	role	NN
cord-314109-wb45naw2	101	5	that	that	WDT
cord-314109-wb45naw2	101	6	mTOR	mTOR	NNP
cord-314109-wb45naw2	101	7	pathways	pathway	NNS
cord-314109-wb45naw2	101	8	play	play	VBP
cord-314109-wb45naw2	101	9	with	with	IN
cord-314109-wb45naw2	101	10	virion	virion	NN
cord-314109-wb45naw2	101	11	growth	growth	NN
cord-314109-wb45naw2	101	12	and	and	CC
cord-314109-wb45naw2	101	13	expression	expression	NN
cord-314109-wb45naw2	101	14	may	may	MD
cord-314109-wb45naw2	101	15	vary	vary	VB
cord-314109-wb45naw2	101	16	dependent	dependent	JJ
cord-314109-wb45naw2	101	17	upon	upon	IN
cord-314109-wb45naw2	101	18	the	the	DT
cord-314109-wb45naw2	101	19	specific	specific	JJ
cord-314109-wb45naw2	101	20	virion	virion	NN
cord-314109-wb45naw2	101	21	.	.	.
cord-314109-wb45naw2	102	1	For	for	IN
cord-314109-wb45naw2	102	2	example	example	NN
cord-314109-wb45naw2	102	3	,	,	,
cord-314109-wb45naw2	102	4	activation	activation	NN
cord-314109-wb45naw2	102	5	of	of	IN
cord-314109-wb45naw2	102	6	mTOR	mTOR	NNP
cord-314109-wb45naw2	102	7	has	have	VBZ
cord-314109-wb45naw2	102	8	been	be	VBN
cord-314109-wb45naw2	102	9	shown	show	VBN
cord-314109-wb45naw2	102	10	to	to	TO
cord-314109-wb45naw2	102	11	be	be	VB
cord-314109-wb45naw2	102	12	necessary	necessary	JJ
cord-314109-wb45naw2	102	13	for	for	IN
cord-314109-wb45naw2	102	14	antihepatitis	antihepatitis	NNP
cord-314109-wb45naw2	102	15	C	C	NNP
cord-314109-wb45naw2	102	16	activity	activity	NN
cord-314109-wb45naw2	102	17	[	[	-LRB-
cord-314109-wb45naw2	102	18	67	67	CD
cord-314109-wb45naw2	102	19	]	]	-RRB-
cord-314109-wb45naw2	102	20	.	.	.
cord-314109-wb45naw2	103	1	Activation	activation	NN
cord-314109-wb45naw2	103	2	of	of	IN
cord-314109-wb45naw2	103	3	mTOR	mTOR	NNP
cord-314109-wb45naw2	103	4	also	also	RB
cord-314109-wb45naw2	103	5	has	have	VBZ
cord-314109-wb45naw2	103	6	been	be	VBN
cord-314109-wb45naw2	103	7	tied	tie	VBN
cord-314109-wb45naw2	103	8	to	to	IN
cord-314109-wb45naw2	103	9	the	the	DT
cord-314109-wb45naw2	103	10	ability	ability	NN
cord-314109-wb45naw2	103	11	to	to	TO
cord-314109-wb45naw2	103	12	promote	promote	VB
cord-314109-wb45naw2	103	13	natural	natural	JJ
cord-314109-wb45naw2	103	14	killer	killer	NN
cord-314109-wb45naw2	103	15	cell	cell	NN
cord-314109-wb45naw2	103	16	effector	effector	NN
cord-314109-wb45naw2	103	17	function	function	NN
cord-314109-wb45naw2	103	18	that	that	WDT
cord-314109-wb45naw2	103	19	can	can	MD
cord-314109-wb45naw2	103	20	be	be	VB
cord-314109-wb45naw2	103	21	necessary	necessary	JJ
cord-314109-wb45naw2	103	22	to	to	TO
cord-314109-wb45naw2	103	23	destroy	destroy	VB
cord-314109-wb45naw2	103	24	virus	virus	NN
cord-314109-wb45naw2	103	25	-	-	HYPH
cord-314109-wb45naw2	103	26	infected	infect	VBN
cord-314109-wb45naw2	103	27	cells	cell	NNS
cord-314109-wb45naw2	103	28	[	[	-LRB-
cord-314109-wb45naw2	103	29	68	68	CD
cord-314109-wb45naw2	103	30	]	]	-RRB-
cord-314109-wb45naw2	103	31	.	.	.
cord-314109-wb45naw2	104	1	In	in	IN
cord-314109-wb45naw2	104	2	relation	relation	NN
cord-314109-wb45naw2	104	3	to	to	IN
cord-314109-wb45naw2	104	4	influenza	influenza	NN
cord-314109-wb45naw2	104	5	A	a	DT
cord-314109-wb45naw2	104	6	virus	virus	NN
cord-314109-wb45naw2	104	7	,	,	,
cord-314109-wb45naw2	104	8	studies	study	NNS
cord-314109-wb45naw2	104	9	illustrate	illustrate	VBP
cord-314109-wb45naw2	104	10	that	that	IN
cord-314109-wb45naw2	104	11	loss	loss	NN
cord-314109-wb45naw2	104	12	or	or	CC
cord-314109-wb45naw2	104	13	inhibition	inhibition	NN
cord-314109-wb45naw2	104	14	of	of	IN
cord-314109-wb45naw2	104	15	mTOR	mTOR	NNP
cord-314109-wb45naw2	104	16	activity	activity	NN
cord-314109-wb45naw2	104	17	with	with	IN
cord-314109-wb45naw2	104	18	the	the	DT
cord-314109-wb45naw2	104	19	corresponding	corresponding	JJ
cord-314109-wb45naw2	104	20	activation	activation	NN
cord-314109-wb45naw2	104	21	of	of	IN
cord-314109-wb45naw2	104	22	AMPK	AMPK	NNP
cord-314109-wb45naw2	104	23	can	can	MD
cord-314109-wb45naw2	104	24	promote	promote	VB
cord-314109-wb45naw2	104	25	viral	viral	JJ
cord-314109-wb45naw2	104	26	replication	replication	NN
cord-314109-wb45naw2	104	27	[	[	-LRB-
cord-314109-wb45naw2	104	28	69	69	CD
cord-314109-wb45naw2	104	29	]	]	-RRB-
cord-314109-wb45naw2	104	30	.	.	.
cord-314109-wb45naw2	105	1	Recent	recent	JJ
cord-314109-wb45naw2	105	2	work	work	NN
cord-314109-wb45naw2	105	3	also	also	RB
cord-314109-wb45naw2	105	4	suggests	suggest	VBZ
cord-314109-wb45naw2	105	5	that	that	IN
cord-314109-wb45naw2	105	6	seasonal	seasonal	JJ
cord-314109-wb45naw2	105	7	vaccination	vaccination	NN
cord-314109-wb45naw2	105	8	for	for	IN
cord-314109-wb45naw2	105	9	influenza	influenza	NN
cord-314109-wb45naw2	105	10	virus	virus	NN
cord-314109-wb45naw2	105	11	in	in	IN
cord-314109-wb45naw2	105	12	individuals	individual	NNS
cord-314109-wb45naw2	105	13	with	with	IN
cord-314109-wb45naw2	105	14	type	type	NN
cord-314109-wb45naw2	105	15	2	2	CD
cord-314109-wb45naw2	105	16	DM	dm	NN
cord-314109-wb45naw2	105	17	and	and	CC
cord-314109-wb45naw2	105	18	treated	treat	VBN
cord-314109-wb45naw2	105	19	with	with	IN
cord-314109-wb45naw2	105	20	metformin	metformin	NNP
cord-314109-wb45naw2	105	21	,	,	,
cord-314109-wb45naw2	105	22	an	an	DT
cord-314109-wb45naw2	105	23	agent	agent	NN
cord-314109-wb45naw2	105	24	that	that	WDT
cord-314109-wb45naw2	105	25	activates	activate	VBZ
cord-314109-wb45naw2	105	26	AMPK	AMPK	NNP
cord-314109-wb45naw2	105	27	and	and	CC
cord-314109-wb45naw2	105	28	blocks	block	VBZ
cord-314109-wb45naw2	105	29	mTOR	mTOR	NNP
cord-314109-wb45naw2	105	30	activity	activity	NN
cord-314109-wb45naw2	105	31	,	,	,
cord-314109-wb45naw2	105	32	can	can	MD
cord-314109-wb45naw2	105	33	lead	lead	VB
cord-314109-wb45naw2	105	34	to	to	IN
cord-314109-wb45naw2	105	35	suppression	suppression	NN
cord-314109-wb45naw2	105	36	of	of	IN
cord-314109-wb45naw2	105	37	type-1	type-1	NNP
cord-314109-wb45naw2	105	38	interferon	interferon	NN
cord-314109-wb45naw2	105	39	response	response	NN
cord-314109-wb45naw2	105	40	and	and	CC
cord-314109-wb45naw2	105	41	ultimately	ultimately	RB
cord-314109-wb45naw2	105	42	result	result	VB
cord-314109-wb45naw2	105	43	in	in	IN
cord-314109-wb45naw2	105	44	limited	limited	JJ
cord-314109-wb45naw2	105	45	vaccine	vaccine	NN
cord-314109-wb45naw2	105	46	effectiveness	effectiveness	NN
cord-314109-wb45naw2	105	47	[	[	-LRB-
cord-314109-wb45naw2	105	48	70	70	CD
cord-314109-wb45naw2	105	49	]	]	-RRB-
cord-314109-wb45naw2	105	50	.	.	.
cord-314109-wb45naw2	106	1	However	however	RB
cord-314109-wb45naw2	106	2	,	,	,
cord-314109-wb45naw2	106	3	it	-PRON-	PRP
cord-314109-wb45naw2	106	4	is	be	VBZ
cord-314109-wb45naw2	106	5	interesting	interesting	JJ
cord-314109-wb45naw2	106	6	to	to	TO
cord-314109-wb45naw2	106	7	note	note	VB
cord-314109-wb45naw2	106	8	that	that	IN
cord-314109-wb45naw2	106	9	the	the	DT
cord-314109-wb45naw2	106	10	regulation	regulation	NN
cord-314109-wb45naw2	106	11	of	of	IN
cord-314109-wb45naw2	106	12	mTOR	mTOR	NNP
cord-314109-wb45naw2	106	13	activity	activity	NN
cord-314109-wb45naw2	106	14	may	may	MD
cord-314109-wb45naw2	106	15	be	be	VB
cord-314109-wb45naw2	106	16	critical	critical	JJ
cord-314109-wb45naw2	106	17	for	for	IN
cord-314109-wb45naw2	106	18	controlling	control	VBG
cord-314109-wb45naw2	106	19	viral	viral	JJ
cord-314109-wb45naw2	106	20	infection	infection	NN
cord-314109-wb45naw2	106	21	and	and	CC
cord-314109-wb45naw2	106	22	replication	replication	NN
cord-314109-wb45naw2	106	23	.	.	.
cord-314109-wb45naw2	107	1	Studies	study	NNS
cord-314109-wb45naw2	107	2	have	have	VBP
cord-314109-wb45naw2	107	3	illustrated	illustrate	VBN
cord-314109-wb45naw2	107	4	that	that	IN
cord-314109-wb45naw2	107	5	mTORC1	mTORC1	NNP
cord-314109-wb45naw2	107	6	activity	activity	NN
cord-314109-wb45naw2	107	7	can	can	MD
cord-314109-wb45naw2	107	8	suppress	suppress	VB
cord-314109-wb45naw2	107	9	hepatitis	hepatitis	NN
cord-314109-wb45naw2	107	10	C	c	NN
cord-314109-wb45naw2	107	11	virus	virus	NN
cord-314109-wb45naw2	107	12	replication	replication	NN
cord-314109-wb45naw2	107	13	,	,	,
cord-314109-wb45naw2	107	14	but	but	CC
cord-314109-wb45naw2	107	15	also	also	RB
cord-314109-wb45naw2	107	16	may	may	MD
cord-314109-wb45naw2	107	17	foster	foster	VB
cord-314109-wb45naw2	107	18	the	the	DT
cord-314109-wb45naw2	107	19	packing	packing	NN
cord-314109-wb45naw2	107	20	of	of	IN
cord-314109-wb45naw2	107	21	the	the	DT
cord-314109-wb45naw2	107	22	virion	virion	NN
cord-314109-wb45naw2	107	23	and	and	CC
cord-314109-wb45naw2	107	24	its	-PRON-	PRP$
cord-314109-wb45naw2	107	25	release	release	NN
cord-314109-wb45naw2	107	26	from	from	IN
cord-314109-wb45naw2	107	27	cells	cell	NNS
cord-314109-wb45naw2	107	28	[	[	-LRB-
cord-314109-wb45naw2	107	29	71	71	CD
cord-314109-wb45naw2	107	30	]	]	-RRB-
cord-314109-wb45naw2	107	31	.	.	.
cord-314109-wb45naw2	108	1	A	a	DT
cord-314109-wb45naw2	108	2	number	number	NN
cord-314109-wb45naw2	108	3	of	of	IN
cord-314109-wb45naw2	108	4	viral	viral	JJ
cord-314109-wb45naw2	108	5	infections	infection	NNS
cord-314109-wb45naw2	108	6	in	in	IN
cord-314109-wb45naw2	108	7	humans	human	NNS
cord-314109-wb45naw2	108	8	can	can	MD
cord-314109-wb45naw2	108	9	ultimately	ultimately	RB
cord-314109-wb45naw2	108	10	lead	lead	VB
cord-314109-wb45naw2	108	11	to	to	IN
cord-314109-wb45naw2	108	12	progressive	progressive	JJ
cord-314109-wb45naw2	108	13	disease	disease	NN
cord-314109-wb45naw2	108	14	and	and	CC
cord-314109-wb45naw2	108	15	disability	disability	NN
cord-314109-wb45naw2	108	16	(	(	-LRB-
cord-314109-wb45naw2	108	17	Table	Table	NNP
cord-314109-wb45naw2	108	18	1	1	CD
cord-314109-wb45naw2	108	19	)	)	-RRB-
cord-314109-wb45naw2	108	20	.	.	.
cord-314109-wb45naw2	109	1	Currently	currently	RB
cord-314109-wb45naw2	109	2	,	,	,
cord-314109-wb45naw2	109	3	the	the	DT
cord-314109-wb45naw2	109	4	SARS	SARS	NNP
cord-314109-wb45naw2	109	5	-	-	HYPH
cord-314109-wb45naw2	109	6	CoV-2	CoV-2	NNP
cord-314109-wb45naw2	109	7	virus	virus	NN
cord-314109-wb45naw2	109	8	has	have	VBZ
cord-314109-wb45naw2	109	9	become	become	VBN
cord-314109-wb45naw2	109	10	a	a	DT
cord-314109-wb45naw2	109	11	global	global	JJ
cord-314109-wb45naw2	109	12	concern	concern	NN
cord-314109-wb45naw2	109	13	.	.	.
cord-314109-wb45naw2	110	1	With	with	IN
cord-314109-wb45naw2	110	2	the	the	DT
cord-314109-wb45naw2	110	3	infection	infection	NN
cord-314109-wb45naw2	110	4	of	of	IN
cord-314109-wb45naw2	110	5	more	more	JJR
cord-314109-wb45naw2	110	6	than	than	IN
cord-314109-wb45naw2	110	7	two	two	CD
cord-314109-wb45naw2	110	8	million	million	CD
cord-314109-wb45naw2	110	9	individuals	individual	NNS
cord-314109-wb45naw2	110	10	throughout	throughout	IN
cord-314109-wb45naw2	110	11	the	the	DT
cord-314109-wb45naw2	110	12	world	world	NN
cord-314109-wb45naw2	110	13	,	,	,
cord-314109-wb45naw2	110	14	the	the	DT
cord-314109-wb45naw2	110	15	expansion	expansion	NN
cord-314109-wb45naw2	110	16	of	of	IN
cord-314109-wb45naw2	110	17	COVID-19	COVID-19	NNP
cord-314109-wb45naw2	110	18	among	among	IN
cord-314109-wb45naw2	110	19	the	the	DT
cord-314109-wb45naw2	110	20	world	world	NN
cord-314109-wb45naw2	110	21	's	's	POS
cord-314109-wb45naw2	110	22	population	population	NN
cord-314109-wb45naw2	110	23	has	have	VBZ
cord-314109-wb45naw2	110	24	led	lead	VBN
cord-314109-wb45naw2	110	25	to	to	IN
cord-314109-wb45naw2	110	26	not	not	RB
cord-314109-wb45naw2	110	27	only	only	RB
cord-314109-wb45naw2	110	28	concerns	concern	NNS
cord-314109-wb45naw2	110	29	for	for	IN
cord-314109-wb45naw2	110	30	the	the	DT
cord-314109-wb45naw2	110	31	development	development	NN
cord-314109-wb45naw2	110	32	of	of	IN
cord-314109-wb45naw2	110	33	behavioral	behavioral	JJ
cord-314109-wb45naw2	110	34	health	health	NN
cord-314109-wb45naw2	110	35	and	and	CC
cord-314109-wb45naw2	110	36	physical	physical	JJ
cord-314109-wb45naw2	110	37	health	health	NN
cord-314109-wb45naw2	110	38	impairments	impairment	NNS
cord-314109-wb45naw2	110	39	,	,	,
cord-314109-wb45naw2	110	40	but	but	CC
cord-314109-wb45naw2	110	41	also	also	RB
cord-314109-wb45naw2	110	42	challenges	challenge	VBZ
cord-314109-wb45naw2	110	43	for	for	IN
cord-314109-wb45naw2	110	44	global	global	JJ
cord-314109-wb45naw2	110	45	economies	economy	NNS
cord-314109-wb45naw2	110	46	.	.	.
cord-314109-wb45naw2	111	1	SARS	SARS	NNP
cord-314109-wb45naw2	111	2	-	-	HYPH
cord-314109-wb45naw2	111	3	CoV-2	CoV-2	NNP
cord-314109-wb45naw2	111	4	gains	gain	VBZ
cord-314109-wb45naw2	111	5	access	access	NN
cord-314109-wb45naw2	111	6	to	to	IN
cord-314109-wb45naw2	111	7	host	host	NN
cord-314109-wb45naw2	111	8	cells	cell	NNS
cord-314109-wb45naw2	111	9	through	through	IN
cord-314109-wb45naw2	111	10	ACE2	ACE2	NNP
cord-314109-wb45naw2	111	11	receptors	receptor	NNS
cord-314109-wb45naw2	111	12	and	and	CC
cord-314109-wb45naw2	111	13	can	can	MD
cord-314109-wb45naw2	111	14	result	result	VB
cord-314109-wb45naw2	111	15	in	in	IN
cord-314109-wb45naw2	111	16	a	a	DT
cord-314109-wb45naw2	111	17	hyperinflammatory	hyperinflammatory	JJ
cord-314109-wb45naw2	111	18	process	process	NN
cord-314109-wb45naw2	111	19	leading	lead	VBG
cord-314109-wb45naw2	111	20	to	to	IN
cord-314109-wb45naw2	111	21	severe	severe	JJ
cord-314109-wb45naw2	111	22	disability	disability	NN
cord-314109-wb45naw2	111	23	and	and	CC
cord-314109-wb45naw2	111	24	ultimately	ultimately	RB
cord-314109-wb45naw2	111	25	death	death	NN
cord-314109-wb45naw2	111	26	.	.	.
cord-314109-wb45naw2	112	1	Given	give	VBN
cord-314109-wb45naw2	112	2	the	the	DT
cord-314109-wb45naw2	112	3	challenges	challenge	NNS
cord-314109-wb45naw2	112	4	presented	present	VBN
cord-314109-wb45naw2	112	5	by	by	IN
cord-314109-wb45naw2	112	6	COVID-19	COVID-19	NNP
cord-314109-wb45naw2	112	7	,	,	,
cord-314109-wb45naw2	112	8	enormous	enormous	JJ
cord-314109-wb45naw2	112	9	resources	resource	NNS
cord-314109-wb45naw2	112	10	are	be	VBP
cord-314109-wb45naw2	112	11	being	be	VBG
cord-314109-wb45naw2	112	12	used	use	VBN
cord-314109-wb45naw2	112	13	to	to	TO
cord-314109-wb45naw2	112	14	develop	develop	VB
cord-314109-wb45naw2	112	15	new	new	JJ
cord-314109-wb45naw2	112	16	therapeutic	therapeutic	JJ
cord-314109-wb45naw2	112	17	strategies	strategy	NNS
cord-314109-wb45naw2	112	18	and	and	CC
cord-314109-wb45naw2	112	19	possible	possible	JJ
cord-314109-wb45naw2	112	20	vaccines	vaccine	NNS
cord-314109-wb45naw2	112	21	for	for	IN
cord-314109-wb45naw2	112	22	the	the	DT
cord-314109-wb45naw2	112	23	treatment	treatment	NN
cord-314109-wb45naw2	112	24	of	of	IN
cord-314109-wb45naw2	112	25	COVID-19	COVID-19	NNP
cord-314109-wb45naw2	112	26	since	since	IN
cord-314109-wb45naw2	112	27	current	current	JJ
cord-314109-wb45naw2	112	28	care	care	NN
cord-314109-wb45naw2	112	29	is	be	VBZ
cord-314109-wb45naw2	112	30	primarily	primarily	RB
cord-314109-wb45naw2	112	31	symptomatic	symptomatic	JJ
cord-314109-wb45naw2	112	32	.	.	.
cord-314109-wb45naw2	113	1	A	a	DT
cord-314109-wb45naw2	113	2	number	number	NN
cord-314109-wb45naw2	113	3	of	of	IN
cord-314109-wb45naw2	113	4	investigations	investigation	NNS
cord-314109-wb45naw2	113	5	seek	seek	VBP
cord-314109-wb45naw2	113	6	to	to	TO
cord-314109-wb45naw2	113	7	repurpose	repurpose	VB
cord-314109-wb45naw2	113	8	existing	exist	VBG
cord-314109-wb45naw2	113	9	antiviral	antiviral	JJ
cord-314109-wb45naw2	113	10	treatments	treatment	NNS
cord-314109-wb45naw2	113	11	for	for	IN
cord-314109-wb45naw2	113	12	COVID-19	COVID-19	NNP
cord-314109-wb45naw2	113	13	.	.	.
cord-314109-wb45naw2	114	1	Yet	yet	RB
cord-314109-wb45naw2	114	2	,	,	,
cord-314109-wb45naw2	114	3	other	other	JJ
cord-314109-wb45naw2	114	4	strategies	strategy	NNS
cord-314109-wb45naw2	114	5	not	not	RB
cord-314109-wb45naw2	114	6	traditionally	traditionally	RB
cord-314109-wb45naw2	114	7	considered	consider	VBN
cord-314109-wb45naw2	114	8	to	to	TO
cord-314109-wb45naw2	114	9	have	have	VB
cord-314109-wb45naw2	114	10	antiviral	antiviral	JJ
cord-314109-wb45naw2	114	11	treatment	treatment	NN
cord-314109-wb45naw2	114	12	capabilities	capability	NNS
cord-314109-wb45naw2	114	13	may	may	MD
cord-314109-wb45naw2	114	14	prove	prove	VB
cord-314109-wb45naw2	114	15	exceedingly	exceedingly	RB
cord-314109-wb45naw2	114	16	useful	useful	JJ
cord-314109-wb45naw2	114	17	as	as	RB
cord-314109-wb45naw2	114	18	well	well	RB
cord-314109-wb45naw2	114	19	.	.	.
cord-314109-wb45naw2	115	1	In	in	IN
cord-314109-wb45naw2	115	2	this	this	DT
cord-314109-wb45naw2	115	3	respect	respect	NN
cord-314109-wb45naw2	115	4	,	,	,
cord-314109-wb45naw2	115	5	mTOR	mTOR	NNP
cord-314109-wb45naw2	115	6	and	and	CC
cord-314109-wb45naw2	115	7	its	-PRON-	PRP$
cord-314109-wb45naw2	115	8	asso	asso	NNP
cord-314109-wb45naw2	115	9	-	-	HYPH
cord-314109-wb45naw2	115	10	ciated	ciate	VBN
cord-314109-wb45naw2	115	11	pathways	pathway	NNS
cord-314109-wb45naw2	115	12	with	with	IN
cord-314109-wb45naw2	115	13	mTORC1	mTORC1	NNP
cord-314109-wb45naw2	115	14	,	,	,
cord-314109-wb45naw2	115	15	mTORC2	mTORC2	JJS
cord-314109-wb45naw2	115	16	,	,	,
cord-314109-wb45naw2	115	17	and	and	CC
cord-314109-wb45naw2	115	18	AMPK	AMPK	NNP
cord-314109-wb45naw2	115	19	offer	offer	VBP
cord-314109-wb45naw2	115	20	exciting	exciting	JJ
cord-314109-wb45naw2	115	21	potential	potential	NN
cord-314109-wb45naw2	115	22	as	as	IN
cord-314109-wb45naw2	115	23	new	new	JJ
cord-314109-wb45naw2	115	24	antiviral	antiviral	JJ
cord-314109-wb45naw2	115	25	therapies	therapy	NNS
cord-314109-wb45naw2	115	26	.	.	.
cord-314109-wb45naw2	116	1	Recent	recent	JJ
cord-314109-wb45naw2	116	2	studies	study	NNS
cord-314109-wb45naw2	116	3	have	have	VBP
cord-314109-wb45naw2	116	4	shown	show	VBN
cord-314109-wb45naw2	116	5	that	that	IN
cord-314109-wb45naw2	116	6	mTOR	mTOR	NNP
cord-314109-wb45naw2	116	7	inhibition	inhibition	NN
cord-314109-wb45naw2	116	8	with	with	IN
cord-314109-wb45naw2	116	9	AMPK	AMPK	NNP
cord-314109-wb45naw2	116	10	activation	activation	NN
cord-314109-wb45naw2	116	11	may	may	MD
cord-314109-wb45naw2	116	12	be	be	VB
cord-314109-wb45naw2	116	13	considered	consider	VBN
cord-314109-wb45naw2	116	14	as	as	IN
cord-314109-wb45naw2	116	15	new	new	JJ
cord-314109-wb45naw2	116	16	targets	target	NNS
cord-314109-wb45naw2	116	17	to	to	TO
cord-314109-wb45naw2	116	18	control	control	VB
cord-314109-wb45naw2	116	19	hyperinflammation	hyperinflammation	NN
cord-314109-wb45naw2	116	20	.	.	.
cord-314109-wb45naw2	117	1	AMPK	AMPK	NNP
cord-314109-wb45naw2	117	2	activation	activation	NN
cord-314109-wb45naw2	117	3	with	with	IN
cord-314109-wb45naw2	117	4	mTOR	mTOR	NNP
cord-314109-wb45naw2	117	5	inhibition	inhibition	NN
cord-314109-wb45naw2	117	6	can	can	MD
cord-314109-wb45naw2	117	7	limit	limit	VB
cord-314109-wb45naw2	117	8	class	class	NN
cord-314109-wb45naw2	117	9	II	ii	CD
cord-314109-wb45naw2	117	10	histocompatibility	histocompatibility	NN
cord-314109-wb45naw2	117	11	complex	complex	NN
cord-314109-wb45naw2	117	12	(	(	-LRB-
cord-314109-wb45naw2	117	13	MHC	MHC	NNP
cord-314109-wb45naw2	117	14	)	)	-RRB-
cord-314109-wb45naw2	117	15	molecules	molecule	VBZ
cord-314109-wb45naw2	117	16	activity	activity	NN
cord-314109-wb45naw2	117	17	,	,	,
cord-314109-wb45naw2	117	18	block	block	NN
cord-314109-wb45naw2	117	19	IL-1beta	il-1beta	NN
cord-314109-wb45naw2	117	20	,	,	,
cord-314109-wb45naw2	117	21	IL-6	IL-6	NNP
cord-314109-wb45naw2	117	22	,	,	,
cord-314109-wb45naw2	117	23	TNF	TNF	NNP
cord-314109-wb45naw2	117	24	and	and	CC
cord-314109-wb45naw2	117	25	CCL	CCL	NNP
cord-314109-wb45naw2	117	26	expression	expression	NN
cord-314109-wb45naw2	117	27	,	,	,
cord-314109-wb45naw2	117	28	and	and	CC
cord-314109-wb45naw2	117	29	reduce	reduce	VB
cord-314109-wb45naw2	117	30	the	the	DT
cord-314109-wb45naw2	117	31	presence	presence	NN
cord-314109-wb45naw2	117	32	of	of	IN
cord-314109-wb45naw2	117	33	adhesion	adhesion	NN
cord-314109-wb45naw2	117	34	molecules	molecule	NNS
cord-314109-wb45naw2	117	35	to	to	TO
cord-314109-wb45naw2	117	36	prevent	prevent	VB
cord-314109-wb45naw2	117	37	cell	cell	NN
cord-314109-wb45naw2	117	38	injury	injury	NN
cord-314109-wb45naw2	117	39	.	.	.
cord-314109-wb45naw2	118	1	Given	give	VBN
cord-314109-wb45naw2	118	2	that	that	IN
cord-314109-wb45naw2	118	3	individuals	individual	NNS
cord-314109-wb45naw2	118	4	with	with	IN
cord-314109-wb45naw2	118	5	significant	significant	JJ
cord-314109-wb45naw2	118	6	co	co	NNS
cord-314109-wb45naw2	118	7	-	-	NNS
cord-314109-wb45naw2	118	8	morbidities	morbidity	NNS
cord-314109-wb45naw2	118	9	with	with	IN
cord-314109-wb45naw2	118	10	DM	DM	NNP
cord-314109-wb45naw2	118	11	have	have	VBP
cord-314109-wb45naw2	118	12	increased	increase	VBN
cord-314109-wb45naw2	118	13	risk	risk	NN
cord-314109-wb45naw2	118	14	for	for	IN
cord-314109-wb45naw2	118	15	developing	develop	VBG
cord-314109-wb45naw2	118	16	illness	illness	NN
cord-314109-wb45naw2	118	17	with	with	IN
cord-314109-wb45naw2	118	18	COVID-19	COVID-19	NNP
cord-314109-wb45naw2	118	19	,	,	,
cord-314109-wb45naw2	118	20	addressing	address	VBG
cord-314109-wb45naw2	118	21	avenues	avenue	NNS
cord-314109-wb45naw2	118	22	linked	link	VBN
cord-314109-wb45naw2	118	23	to	to	IN
cord-314109-wb45naw2	118	24	metabolic	metabolic	JJ
cord-314109-wb45naw2	118	25	disease	disease	NN
cord-314109-wb45naw2	118	26	and	and	CC
cord-314109-wb45naw2	118	27	mTOR	mTOR	NNP
cord-314109-wb45naw2	118	28	pathways	pathway	NNS
cord-314109-wb45naw2	118	29	also	also	RB
cord-314109-wb45naw2	118	30	may	may	MD
cord-314109-wb45naw2	118	31	offer	offer	VB
cord-314109-wb45naw2	118	32	some	some	DT
cord-314109-wb45naw2	118	33	utility	utility	NN
cord-314109-wb45naw2	118	34	.	.	.
cord-314109-wb45naw2	119	1	Agents	agent	NNS
cord-314109-wb45naw2	119	2	such	such	JJ
cord-314109-wb45naw2	119	3	as	as	IN
cord-314109-wb45naw2	119	4	metformin	metformin	NNP
cord-314109-wb45naw2	119	5	that	that	WDT
cord-314109-wb45naw2	119	6	promotes	promote	VBZ
cord-314109-wb45naw2	119	7	AMPK	AMPK	NNP
cord-314109-wb45naw2	119	8	activation	activation	NN
cord-314109-wb45naw2	119	9	may	may	MD
cord-314109-wb45naw2	119	10	limit	limit	VB
cord-314109-wb45naw2	119	11	oxidative	oxidative	JJ
cord-314109-wb45naw2	119	12	stress	stress	NN
cord-314109-wb45naw2	119	13	cell	cell	NN
cord-314109-wb45naw2	119	14	injury	injury	NN
cord-314109-wb45naw2	119	15	,	,	,
cord-314109-wb45naw2	119	16	reduce	reduce	VB
cord-314109-wb45naw2	119	17	excessive	excessive	JJ
cord-314109-wb45naw2	119	18	inflammatory	inflammatory	JJ
cord-314109-wb45naw2	119	19	cell	cell	NN
cord-314109-wb45naw2	119	20	activation	activation	NN
cord-314109-wb45naw2	119	21	,	,	,
cord-314109-wb45naw2	119	22	and	and	CC
cord-314109-wb45naw2	119	23	may	may	MD
cord-314109-wb45naw2	119	24	be	be	VB
cord-314109-wb45naw2	119	25	a	a	DT
cord-314109-wb45naw2	119	26	useful	useful	JJ
cord-314109-wb45naw2	119	27	therapy	therapy	NN
cord-314109-wb45naw2	119	28	for	for	IN
cord-314109-wb45naw2	119	29	the	the	DT
cord-314109-wb45naw2	119	30	treatment	treatment	NN
cord-314109-wb45naw2	119	31	of	of	IN
cord-314109-wb45naw2	119	32	COVID-19	COVID-19	NNP
cord-314109-wb45naw2	119	33	involving	involve	VBG
cord-314109-wb45naw2	119	34	potential	potential	JJ
cord-314109-wb45naw2	119	35	adjuvant	adjuvant	JJ
cord-314109-wb45naw2	119	36	agents	agent	NNS
cord-314109-wb45naw2	119	37	such	such	JJ
cord-314109-wb45naw2	119	38	as	as	IN
cord-314109-wb45naw2	119	39	hydroxychloroquine	hydroxychloroquine	NNP
cord-314109-wb45naw2	119	40	.	.	.
cord-314109-wb45naw2	120	1	It	-PRON-	PRP
cord-314109-wb45naw2	120	2	is	be	VBZ
cord-314109-wb45naw2	120	3	important	important	JJ
cord-314109-wb45naw2	120	4	to	to	TO
cord-314109-wb45naw2	120	5	realize	realize	VB
cord-314109-wb45naw2	120	6	that	that	IN
cord-314109-wb45naw2	120	7	the	the	DT
cord-314109-wb45naw2	120	8	development	development	NN
cord-314109-wb45naw2	120	9	of	of	IN
cord-314109-wb45naw2	120	10	these	these	DT
cord-314109-wb45naw2	120	11	antiviral	antiviral	JJ
cord-314109-wb45naw2	120	12	pathways	pathway	NNS
cord-314109-wb45naw2	120	13	for	for	IN
cord-314109-wb45naw2	120	14	mTOR	mTOR	NNP
cord-314109-wb45naw2	120	15	is	be	VBZ
cord-314109-wb45naw2	120	16	at	at	IN
cord-314109-wb45naw2	120	17	an	an	DT
cord-314109-wb45naw2	120	18	early	early	JJ
cord-314109-wb45naw2	120	19	conceptual	conceptual	JJ
cord-314109-wb45naw2	120	20	phase	phase	NN
cord-314109-wb45naw2	120	21	and	and	CC
cord-314109-wb45naw2	120	22	that	that	IN
cord-314109-wb45naw2	120	23	other	other	JJ
cord-314109-wb45naw2	120	24	studies	study	NNS
cord-314109-wb45naw2	120	25	support	support	VBP
cord-314109-wb45naw2	120	26	a	a	DT
cord-314109-wb45naw2	120	27	role	role	NN
cord-314109-wb45naw2	120	28	for	for	IN
cord-314109-wb45naw2	120	29	mTOR	mTOR	NNP
cord-314109-wb45naw2	120	30	activation	activation	NN
cord-314109-wb45naw2	120	31	in	in	IN
cord-314109-wb45naw2	120	32	controlling	control	VBG
cord-314109-wb45naw2	120	33	immune	immune	JJ
cord-314109-wb45naw2	120	34	system	system	NN
cord-314109-wb45naw2	120	35	response	response	NN
cord-314109-wb45naw2	120	36	and	and	CC
cord-314109-wb45naw2	120	37	antiviral	antiviral	JJ
cord-314109-wb45naw2	120	38	activity	activity	NN
cord-314109-wb45naw2	120	39	.	.	.
cord-314109-wb45naw2	121	1	mTORC1	mTORC1	NNP
cord-314109-wb45naw2	121	2	and	and	CC
cord-314109-wb45naw2	121	3	mTORC2	mTORC2	NNP
cord-314109-wb45naw2	121	4	activation	activation	NN
cord-314109-wb45naw2	121	5	can	can	MD
cord-314109-wb45naw2	121	6	promote	promote	VB
cord-314109-wb45naw2	121	7	antiinflammatory	antiinflammatory	JJ
cord-314109-wb45naw2	121	8	cytokine	cytokine	NN
cord-314109-wb45naw2	121	9	IL-10	IL-10	NNP
cord-314109-wb45naw2	121	10	production	production	NN
cord-314109-wb45naw2	121	11	to	to	TO
cord-314109-wb45naw2	121	12	block	block	VB
cord-314109-wb45naw2	121	13	apoptosis	apoptosis	NN
cord-314109-wb45naw2	121	14	.	.	.
cord-314109-wb45naw2	122	1	mTOR	mTOR	NNP
cord-314109-wb45naw2	122	2	activation	activation	NN
cord-314109-wb45naw2	122	3	also	also	RB
cord-314109-wb45naw2	122	4	can	can	MD
cord-314109-wb45naw2	122	5	inhibit	inhibit	VB
cord-314109-wb45naw2	122	6	the	the	DT
cord-314109-wb45naw2	122	7	pro	pro	JJ
cord-314109-wb45naw2	122	8	-	-	JJ
cord-314109-wb45naw2	122	9	inflammatory	inflammatory	JJ
cord-314109-wb45naw2	122	10	cytokine	cytokine	NN
cord-314109-wb45naw2	122	11	TNF	tnf	NN
cord-314109-wb45naw2	122	12	-	-	HYPH
cord-314109-wb45naw2	122	13	α	α	NNP
cord-314109-wb45naw2	122	14	and	and	CC
cord-314109-wb45naw2	122	15	increase	increase	VB
cord-314109-wb45naw2	122	16	anti	anti	JJ
cord-314109-wb45naw2	122	17	-	-	JJ
cord-314109-wb45naw2	122	18	inflammatory	inflammatory	JJ
cord-314109-wb45naw2	122	19	cytokine	cytokine	NN
cord-314109-wb45naw2	122	20	IL-10	IL-10	NNP
cord-314109-wb45naw2	122	21	activity	activity	NN
cord-314109-wb45naw2	122	22	.	.	.
cord-314109-wb45naw2	123	1	Furthermore	furthermore	RB
cord-314109-wb45naw2	123	2	,	,	,
cord-314109-wb45naw2	123	3	mTOR	mTOR	NNP
cord-314109-wb45naw2	123	4	activation	activation	NN
cord-314109-wb45naw2	123	5	has	have	VBZ
cord-314109-wb45naw2	123	6	been	be	VBN
cord-314109-wb45naw2	123	7	shown	show	VBN
cord-314109-wb45naw2	123	8	to	to	TO
cord-314109-wb45naw2	123	9	be	be	VB
cord-314109-wb45naw2	123	10	necessary	necessary	JJ
cord-314109-wb45naw2	123	11	for	for	IN
cord-314109-wb45naw2	123	12	anti	anti	JJ
cord-314109-wb45naw2	123	13	-	-	JJ
cord-314109-wb45naw2	123	14	hepatitis	hepatitis	JJ
cord-314109-wb45naw2	123	15	C	c	NN
cord-314109-wb45naw2	123	16	activity	activity	NN
cord-314109-wb45naw2	123	17	,	,	,
cord-314109-wb45naw2	123	18	reduce	reduce	VB
cord-314109-wb45naw2	123	19	influenza	influenza	NN
cord-314109-wb45naw2	123	20	A	a	DT
cord-314109-wb45naw2	123	21	virus	virus	NN
cord-314109-wb45naw2	123	22	replication	replication	NN
cord-314109-wb45naw2	123	23	,	,	,
cord-314109-wb45naw2	123	24	promote	promote	VB
cord-314109-wb45naw2	123	25	natural	natural	JJ
cord-314109-wb45naw2	123	26	killer	killer	NN
cord-314109-wb45naw2	123	27	cell	cell	NN
cord-314109-wb45naw2	123	28	effector	effector	NN
cord-314109-wb45naw2	123	29	function	function	NN
cord-314109-wb45naw2	123	30	,	,	,
cord-314109-wb45naw2	123	31	and	and	CC
cord-314109-wb45naw2	123	32	be	be	VB
cord-314109-wb45naw2	123	33	required	require	VBN
cord-314109-wb45naw2	123	34	for	for	IN
cord-314109-wb45naw2	123	35	type-1	type-1	NN
cord-314109-wb45naw2	123	36	interferon	interferon	NN
cord-314109-wb45naw2	123	37	response	response	NN
cord-314109-wb45naw2	123	38	to	to	TO
cord-314109-wb45naw2	123	39	raise	raise	VB
cord-314109-wb45naw2	123	40	influenza	influenza	NN
cord-314109-wb45naw2	123	41	vaccination	vaccination	NN
cord-314109-wb45naw2	123	42	effectiveness	effectiveness	NN
cord-314109-wb45naw2	123	43	.	.	.
cord-314109-wb45naw2	124	1	Yet	yet	RB
cord-314109-wb45naw2	124	2	,	,	,
cord-314109-wb45naw2	124	3	there	there	EX
cord-314109-wb45naw2	124	4	exists	exist	VBZ
cord-314109-wb45naw2	124	5	a	a	DT
cord-314109-wb45naw2	124	6	number	number	NN
cord-314109-wb45naw2	124	7	of	of	IN
cord-314109-wb45naw2	124	8	considerations	consideration	NNS
cord-314109-wb45naw2	124	9	for	for	IN
cord-314109-wb45naw2	124	10	the	the	DT
cord-314109-wb45naw2	124	11	mTOR	mTOR	NNP
cord-314109-wb45naw2	124	12	pathway	pathway	NN
cord-314109-wb45naw2	124	13	in	in	IN
cord-314109-wb45naw2	124	14	the	the	DT
cord-314109-wb45naw2	124	15	development	development	NN
cord-314109-wb45naw2	124	16	of	of	IN
cord-314109-wb45naw2	124	17	efficacious	efficacious	JJ
cord-314109-wb45naw2	124	18	antiviral	antiviral	JJ
cord-314109-wb45naw2	124	19	therapy	therapy	NN
cord-314109-wb45naw2	124	20	.	.	.
cord-314109-wb45naw2	125	1	Regulation	regulation	NN
cord-314109-wb45naw2	125	2	of	of	IN
cord-314109-wb45naw2	125	3	mTOR	mTOR	NNP
cord-314109-wb45naw2	125	4	activity	activity	NN
cord-314109-wb45naw2	125	5	may	may	MD
cord-314109-wb45naw2	125	6	require	require	VB
cord-314109-wb45naw2	125	7	a	a	DT
cord-314109-wb45naw2	125	8	precise	precise	JJ
cord-314109-wb45naw2	125	9	biological	biological	JJ
cord-314109-wb45naw2	125	10	oversight	oversight	NN
cord-314109-wb45naw2	125	11	.	.	.
cord-314109-wb45naw2	126	1	Under	under	IN
cord-314109-wb45naw2	126	2	some	some	DT
cord-314109-wb45naw2	126	3	circumstances	circumstance	NNS
cord-314109-wb45naw2	126	4	,	,	,
cord-314109-wb45naw2	126	5	pathways	pathway	NNS
cord-314109-wb45naw2	126	6	of	of	IN
cord-314109-wb45naw2	126	7	mTOR	mTOR	NNP
cord-314109-wb45naw2	126	8	,	,	,
cord-314109-wb45naw2	126	9	such	such	JJ
cord-314109-wb45naw2	126	10	as	as	IN
cord-314109-wb45naw2	126	11	mTORC1	mTORC1	NNP
cord-314109-wb45naw2	126	12	,	,	,
cord-314109-wb45naw2	126	13	can	can	MD
cord-314109-wb45naw2	126	14	suppress	suppress	VB
cord-314109-wb45naw2	126	15	hepatitis	hepatitis	NN
cord-314109-wb45naw2	126	16	C	c	NN
cord-314109-wb45naw2	126	17	virus	virus	NN
cord-314109-wb45naw2	126	18	replication	replication	NN
cord-314109-wb45naw2	126	19	,	,	,
cord-314109-wb45naw2	126	20	but	but	CC
cord-314109-wb45naw2	126	21	also	also	RB
cord-314109-wb45naw2	126	22	may	may	MD
cord-314109-wb45naw2	126	23	foster	foster	VB
cord-314109-wb45naw2	126	24	the	the	DT
cord-314109-wb45naw2	126	25	packing	packing	NN
cord-314109-wb45naw2	126	26	of	of	IN
cord-314109-wb45naw2	126	27	the	the	DT
cord-314109-wb45naw2	126	28	virion	virion	NN
cord-314109-wb45naw2	126	29	and	and	CC
cord-314109-wb45naw2	126	30	the	the	DT
cord-314109-wb45naw2	126	31	release	release	NN
cord-314109-wb45naw2	126	32	of	of	IN
cord-314109-wb45naw2	126	33	the	the	DT
cord-314109-wb45naw2	126	34	virion	virion	NN
cord-314109-wb45naw2	126	35	from	from	IN
cord-314109-wb45naw2	126	36	cells	cell	NNS
cord-314109-wb45naw2	126	37	.	.	.
cord-314109-wb45naw2	127	1	In	in	IN
cord-314109-wb45naw2	127	2	addition	addition	NN
cord-314109-wb45naw2	127	3	,	,	,
cord-314109-wb45naw2	127	4	pathways	pathway	NNS
cord-314109-wb45naw2	127	5	of	of	IN
cord-314109-wb45naw2	127	6	mTOR	mTOR	NNP
cord-314109-wb45naw2	127	7	may	may	MD
cord-314109-wb45naw2	127	8	participate	participate	VB
cord-314109-wb45naw2	127	9	in	in	IN
cord-314109-wb45naw2	127	10	some	some	DT
cord-314109-wb45naw2	127	11	virion	virion	NN
cord-314109-wb45naw2	127	12	growth	growth	NN
cord-314109-wb45naw2	127	13	cycles	cycle	NNS
cord-314109-wb45naw2	127	14	and	and	CC
cord-314109-wb45naw2	127	15	expression	expression	NN
cord-314109-wb45naw2	127	16	such	such	JJ
cord-314109-wb45naw2	127	17	as	as	IN
cord-314109-wb45naw2	127	18	with	with	IN
cord-314109-wb45naw2	127	19	the	the	DT
cord-314109-wb45naw2	127	20	West	West	NNP
cord-314109-wb45naw2	127	21	Nile	Nile	NNP
cord-314109-wb45naw2	127	22	virus	virus	NN
cord-314109-wb45naw2	127	23	.	.	.
cord-314109-wb45naw2	128	1	In	in	IN
cord-314109-wb45naw2	128	2	light	light	NN
cord-314109-wb45naw2	128	3	of	of	IN
cord-314109-wb45naw2	128	4	the	the	DT
cord-314109-wb45naw2	128	5	promising	promising	JJ
cord-314109-wb45naw2	128	6	early	early	JJ
cord-314109-wb45naw2	128	7	studies	study	NNS
cord-314109-wb45naw2	128	8	with	with	IN
cord-314109-wb45naw2	128	9	the	the	DT
cord-314109-wb45naw2	128	10	mTOR	mTOR	NNP
cord-314109-wb45naw2	128	11	pathways	pathway	NNS
cord-314109-wb45naw2	128	12	as	as	IN
cord-314109-wb45naw2	128	13	potential	potential	JJ
cord-314109-wb45naw2	128	14	antiviral	antiviral	JJ
cord-314109-wb45naw2	128	15	and	and	CC
cord-314109-wb45naw2	128	16	inflammatory	inflammatory	JJ
cord-314109-wb45naw2	128	17	modulatory	modulatory	JJ
cord-314109-wb45naw2	128	18	targets	target	NNS
cord-314109-wb45naw2	128	19	,	,	,
cord-314109-wb45naw2	128	20	continued	continue	VBN
cord-314109-wb45naw2	128	21	investigations	investigation	NNS
cord-314109-wb45naw2	128	22	will	will	MD
cord-314109-wb45naw2	128	23	be	be	VB
cord-314109-wb45naw2	128	24	critical	critical	JJ
cord-314109-wb45naw2	128	25	to	to	TO
cord-314109-wb45naw2	128	26	gain	gain	VB
cord-314109-wb45naw2	128	27	the	the	DT
cord-314109-wb45naw2	128	28	necessary	necessary	JJ
cord-314109-wb45naw2	128	29	insights	insight	NNS
cord-314109-wb45naw2	128	30	to	to	TO
cord-314109-wb45naw2	128	31	translate	translate	VB
cord-314109-wb45naw2	128	32	mTOR	mTOR	NNP
cord-314109-wb45naw2	128	33	pathways	pathway	NNS
cord-314109-wb45naw2	128	34	into	into	IN
cord-314109-wb45naw2	128	35	effective	effective	JJ
cord-314109-wb45naw2	128	36	clinical	clinical	JJ
cord-314109-wb45naw2	128	37	antiviral	antiviral	JJ
cord-314109-wb45naw2	128	38	strategies	strategy	NNS
cord-314109-wb45naw2	128	39	for	for	IN
cord-314109-wb45naw2	128	40	a	a	DT
cord-314109-wb45naw2	128	41	number	number	NN
cord-314109-wb45naw2	128	42	of	of	IN
cord-314109-wb45naw2	128	43	viral	viral	JJ
cord-314109-wb45naw2	128	44	pathogens	pathogen	NNS
cord-314109-wb45naw2	128	45	.	.	.
cord-314109-wb45naw2	129	1	Not	not	RB
cord-314109-wb45naw2	129	2	applicable	applicable	JJ
cord-314109-wb45naw2	129	3	.	.	.
cord-314109-wb45naw2	130	1	This	this	DT
cord-314109-wb45naw2	130	2	work	work	NN
cord-314109-wb45naw2	130	3	was	be	VBD
cord-314109-wb45naw2	130	4	supported	support	VBN
cord-314109-wb45naw2	130	5	by	by	IN
cord-314109-wb45naw2	130	6	the	the	DT
cord-314109-wb45naw2	130	7	following	following	JJ
cord-314109-wb45naw2	130	8	grants	grant	NNS
cord-314109-wb45naw2	130	9	to	to	IN
cord-314109-wb45naw2	130	10	Kenneth	Kenneth	NNP
cord-314109-wb45naw2	130	11	Maiese	Maiese	NNP
cord-314109-wb45naw2	130	12	:	:	:
cord-314109-wb45naw2	130	13	American	American	NNP
cord-314109-wb45naw2	130	14	Diabetes	Diabetes	NNP
cord-314109-wb45naw2	130	15	Association	Association	NNP
cord-314109-wb45naw2	130	16	,	,	,
cord-314109-wb45naw2	130	17	American	American	NNP
cord-314109-wb45naw2	130	18	Heart	Heart	NNP
cord-314109-wb45naw2	130	19	Association	Association	NNP
cord-314109-wb45naw2	130	20	,	,	,
cord-314109-wb45naw2	130	21	NIH	NIH	NNP
cord-314109-wb45naw2	130	22	NIEHS	NIEHS	NNP
cord-314109-wb45naw2	130	23	,	,	,
cord-314109-wb45naw2	130	24	NIH	NIH	NNP
cord-314109-wb45naw2	130	25	NIA	NIA	NNP
cord-314109-wb45naw2	130	26	,	,	,
cord-314109-wb45naw2	130	27	NIH	NIH	NNP
cord-314109-wb45naw2	130	28	NINDS	NINDS	NNP
cord-314109-wb45naw2	130	29	,	,	,
cord-314109-wb45naw2	130	30	and	and	CC
cord-314109-wb45naw2	130	31	NIH	NIH	NNP
cord-314109-wb45naw2	130	32	ARRA	ARRA	NNP
cord-314109-wb45naw2	130	33	.	.	.
cord-314109-wb45naw2	131	1	The	the	DT
cord-314109-wb45naw2	131	2	author	author	NN
cord-314109-wb45naw2	131	3	declares	declare	VBZ
cord-314109-wb45naw2	131	4	no	no	DT
cord-314109-wb45naw2	131	5	conflict	conflict	NN
cord-314109-wb45naw2	131	6	of	of	IN
cord-314109-wb45naw2	131	7	interest	interest	NN
cord-314109-wb45naw2	131	8	,	,	,
cord-314109-wb45naw2	131	9	financial	financial	JJ
cord-314109-wb45naw2	131	10	or	or	CC
cord-314109-wb45naw2	131	11	otherwise	otherwise	RB
cord-314109-wb45naw2	131	12	.	.	.
cord-314109-wb45naw2	132	1	•	•	NNP
cord-314109-wb45naw2	133	1	Coronaviruses	coronaviruse	NNS
cord-314109-wb45naw2	133	2	affect	affect	VBP
cord-314109-wb45naw2	133	3	multiple	multiple	JJ
cord-314109-wb45naw2	133	4	systems	system	NNS
cord-314109-wb45naw2	133	5	throughout	throughout	IN
cord-314109-wb45naw2	133	6	the	the	DT
cord-314109-wb45naw2	133	7	body	body	NN
cord-314109-wb45naw2	133	8	in	in	IN
cord-314109-wb45naw2	133	9	both	both	DT
cord-314109-wb45naw2	133	10	birds	bird	NNS
cord-314109-wb45naw2	133	11	and	and	CC
cord-314109-wb45naw2	133	12	mammals	mammal	NNS
cord-314109-wb45naw2	133	13	.	.	.
cord-314109-wb45naw2	134	1	The	the	DT
cord-314109-wb45naw2	134	2	β	β	NN
cord-314109-wb45naw2	134	3	-	-	HYPH
cord-314109-wb45naw2	134	4	coronavirus	coronavirus	NN
cord-314109-wb45naw2	134	5	family	family	NN
cord-314109-wb45naw2	134	6	virion	virion	NN
cord-314109-wb45naw2	134	7	,	,	,
cord-314109-wb45naw2	134	8	SARS	SARS	NNP
cord-314109-wb45naw2	134	9	-	-	HYPH
cord-314109-wb45naw2	134	10	CoV-2	CoV-2	NNP
cord-314109-wb45naw2	134	11	,	,	,
cord-314109-wb45naw2	134	12	has	have	VBZ
cord-314109-wb45naw2	134	13	quickly	quickly	RB
cord-314109-wb45naw2	134	14	evolved	evolve	VBN
cord-314109-wb45naw2	134	15	as	as	IN
cord-314109-wb45naw2	134	16	a	a	DT
cord-314109-wb45naw2	134	17	pandemic	pandemic	NN
cord-314109-wb45naw2	134	18	leading	lead	VBG
cord-314109-wb45naw2	134	19	to	to	IN
cord-314109-wb45naw2	134	20	coronavirus	coronavirus	NN
cord-314109-wb45naw2	134	21	disease	disease	NN
cord-314109-wb45naw2	134	22	2019	2019	CD
cord-314109-wb45naw2	134	23	(	(	-LRB-
cord-314109-wb45naw2	134	24	COVID-19	COVID-19	NNP
cord-314109-wb45naw2	134	25	)	)	-RRB-
cord-314109-wb45naw2	134	26	highlighting	highlight	VBG
cord-314109-wb45naw2	134	27	the	the	DT
cord-314109-wb45naw2	134	28	vital	vital	JJ
cord-314109-wb45naw2	134	29	need	need	NN
cord-314109-wb45naw2	134	30	for	for	IN
cord-314109-wb45naw2	134	31	innovative	innovative	JJ
cord-314109-wb45naw2	134	32	strategies	strategy	NNS
cord-314109-wb45naw2	134	33	to	to	TO
cord-314109-wb45naw2	134	34	treat	treat	VB
cord-314109-wb45naw2	134	35	viral	viral	JJ
cord-314109-wb45naw2	134	36	pathogens	pathogen	NNS
cord-314109-wb45naw2	134	37	.	.	.
cord-314109-wb45naw2	135	1	•	•	NNP
cord-314109-wb45naw2	136	1	The	the	DT
cord-314109-wb45naw2	136	2	mechanistic	mechanistic	JJ
cord-314109-wb45naw2	136	3	target	target	NN
cord-314109-wb45naw2	136	4	of	of	IN
cord-314109-wb45naw2	136	5	rapamycin	rapamycin	NNP
cord-314109-wb45naw2	136	6	(	(	-LRB-
cord-314109-wb45naw2	136	7	mTOR	mTOR	NNP
cord-314109-wb45naw2	136	8	)	)	-RRB-
cord-314109-wb45naw2	136	9	and	and	CC
cord-314109-wb45naw2	136	10	its	-PRON-	PRP$
cord-314109-wb45naw2	136	11	associated	associate	VBN
cord-314109-wb45naw2	136	12	pathways	pathway	NNS
cord-314109-wb45naw2	136	13	with	with	IN
cord-314109-wb45naw2	136	14	mTOR	mTOR	NNP
cord-314109-wb45naw2	136	15	Complex	Complex	NNP
cord-314109-wb45naw2	136	16	1	1	CD
cord-314109-wb45naw2	136	17	(	(	-LRB-
cord-314109-wb45naw2	136	18	mTORC1	mTORC1	NNP
cord-314109-wb45naw2	136	19	)	)	-RRB-
cord-314109-wb45naw2	136	20	,	,	.
cord-314109-wb45naw2	137	1	mTOR	mTOR	NNP
cord-314109-wb45naw2	137	2	Complex	Complex	NNP
cord-314109-wb45naw2	137	3	2	2	CD
cord-314109-wb45naw2	137	4	(	(	-LRB-
cord-314109-wb45naw2	137	5	mTORC2	mTORC2	NNPS
cord-314109-wb45naw2	137	6	)	)	-RRB-
cord-314109-wb45naw2	137	7	,	,	,
cord-314109-wb45naw2	137	8	and	and	CC
cord-314109-wb45naw2	137	9	AMP	AMP	NNP
cord-314109-wb45naw2	137	10	activated	activate	VBD
cord-314109-wb45naw2	137	11	protein	protein	NN
cord-314109-wb45naw2	137	12	kinase	kinase	NN
cord-314109-wb45naw2	137	13	(	(	-LRB-
cord-314109-wb45naw2	137	14	AMPK	AMPK	NNP
cord-314109-wb45naw2	137	15	)	)	-RRB-
cord-314109-wb45naw2	137	16	offer	offer	VBP
cord-314109-wb45naw2	137	17	new	new	JJ
cord-314109-wb45naw2	137	18	avenues	avenue	NNS
cord-314109-wb45naw2	137	19	of	of	IN
cord-314109-wb45naw2	137	20	opportunity	opportunity	NN
cord-314109-wb45naw2	137	21	for	for	IN
cord-314109-wb45naw2	137	22	the	the	DT
cord-314109-wb45naw2	137	23	development	development	NN
cord-314109-wb45naw2	137	24	of	of	IN
cord-314109-wb45naw2	137	25	innovative	innovative	JJ
cord-314109-wb45naw2	137	26	antiviral	antiviral	JJ
cord-314109-wb45naw2	137	27	treatment	treatment	NN
cord-314109-wb45naw2	137	28	strategies	strategy	NNS
cord-314109-wb45naw2	137	29	.	.	.
cord-314109-wb45naw2	138	1	•	•	NNP
cord-314109-wb45naw2	139	1	AMPK	AMPK	NNP
cord-314109-wb45naw2	139	2	activation	activation	NN
cord-314109-wb45naw2	139	3	with	with	IN
cord-314109-wb45naw2	139	4	mTOR	mTOR	NNP
cord-314109-wb45naw2	139	5	inhibition	inhibition	NN
cord-314109-wb45naw2	139	6	can	can	MD
cord-314109-wb45naw2	139	7	limit	limit	VB
cord-314109-wb45naw2	139	8	hyperinflammation	hyperinflammation	NN
cord-314109-wb45naw2	139	9	and	and	CC
cord-314109-wb45naw2	139	10	has	have	VBZ
cord-314109-wb45naw2	139	11	been	be	VBN
cord-314109-wb45naw2	139	12	shown	show	VBN
cord-314109-wb45naw2	139	13	to	to	TO
cord-314109-wb45naw2	139	14	inhibit	inhibit	VB
cord-314109-wb45naw2	139	15	class	class	NN
cord-314109-wb45naw2	139	16	II	ii	NN
cord-314109-wb45naw2	139	17	histocompatibility	histocompatibility	NN
cord-314109-wb45naw2	139	18	complex	complex	NN
cord-314109-wb45naw2	139	19	(	(	-LRB-
cord-314109-wb45naw2	139	20	MHC	MHC	NNP
cord-314109-wb45naw2	139	21	)	)	-RRB-
cord-314109-wb45naw2	139	22	molecules	molecule	VBZ
cord-314109-wb45naw2	139	23	activity	activity	NN
cord-314109-wb45naw2	139	24	,	,	,
cord-314109-wb45naw2	139	25	block	block	VB
cord-314109-wb45naw2	139	26	interleukin1β	interleukin1β	NNPS
cord-314109-wb45naw2	140	1	(	(	-LRB-
cord-314109-wb45naw2	140	2	IL-1β	IL-1β	NNP
cord-314109-wb45naw2	140	3	)	)	-RRB-
cord-314109-wb45naw2	140	4	,	,	,
cord-314109-wb45naw2	140	5	IL-6	IL-6	NNP
cord-314109-wb45naw2	140	6	,	,	,
cord-314109-wb45naw2	140	7	tumor	tumor	NN
cord-314109-wb45naw2	140	8	necrosis	necrosis	NN
cord-314109-wb45naw2	140	9	factor	factor	NN
cord-314109-wb45naw2	140	10	(	(	-LRB-
cord-314109-wb45naw2	140	11	TNF	TNF	NNP
cord-314109-wb45naw2	140	12	)	)	-RRB-
cord-314109-wb45naw2	140	13	and	and	CC
cord-314109-wb45naw2	140	14	chemokine	chemokine	NN
cord-314109-wb45naw2	140	15	(	(	-LRB-
cord-314109-wb45naw2	140	16	C	C	NNP
cord-314109-wb45naw2	140	17	-	-	HYPH
cord-314109-wb45naw2	140	18	C	C	NNP
cord-314109-wb45naw2	140	19	motif	motif	NN
cord-314109-wb45naw2	140	20	)	)	-RRB-
cord-314109-wb45naw2	140	21	ligand	ligand	NN
cord-314109-wb45naw2	140	22	(	(	-LRB-
cord-314109-wb45naw2	140	23	CCL	CCL	NNP
cord-314109-wb45naw2	140	24	)	)	-RRB-
cord-314109-wb45naw2	140	25	expression	expression	NN
cord-314109-wb45naw2	140	26	,	,	,
cord-314109-wb45naw2	140	27	and	and	CC
cord-314109-wb45naw2	140	28	reduce	reduce	VB
cord-314109-wb45naw2	140	29	the	the	DT
cord-314109-wb45naw2	140	30	presence	presence	NN
cord-314109-wb45naw2	140	31	of	of	IN
cord-314109-wb45naw2	140	32	adhesion	adhesion	NN
cord-314109-wb45naw2	140	33	molecules	molecule	NNS
cord-314109-wb45naw2	140	34	to	to	TO
cord-314109-wb45naw2	140	35	prevent	prevent	VB
cord-314109-wb45naw2	140	36	cell	cell	NN
cord-314109-wb45naw2	140	37	injury	injury	NN
cord-314109-wb45naw2	140	38	.	.	.
cord-314109-wb45naw2	141	1	•	•	NNP
cord-314109-wb45naw2	142	1	Individuals	individual	NNS
cord-314109-wb45naw2	142	2	with	with	IN
cord-314109-wb45naw2	142	3	diabetes	diabetes	NN
cord-314109-wb45naw2	142	4	mellitus	mellitus	NN
cord-314109-wb45naw2	142	5	have	have	VBP
cord-314109-wb45naw2	142	6	increased	increase	VBN
cord-314109-wb45naw2	142	7	risk	risk	NN
cord-314109-wb45naw2	142	8	for	for	IN
cord-314109-wb45naw2	142	9	developing	develop	VBG
cord-314109-wb45naw2	142	10	illness	illness	NN
cord-314109-wb45naw2	142	11	with	with	IN
cord-314109-wb45naw2	142	12	COVID-19	COVID-19	NNP
cord-314109-wb45naw2	142	13	,	,	,
cord-314109-wb45naw2	142	14	suggesting	suggest	VBG
cord-314109-wb45naw2	142	15	that	that	IN
cord-314109-wb45naw2	142	16	agents	agent	NNS
cord-314109-wb45naw2	142	17	such	such	JJ
cord-314109-wb45naw2	142	18	as	as	IN
cord-314109-wb45naw2	142	19	metformin	metformin	NNP
cord-314109-wb45naw2	142	20	that	that	WDT
cord-314109-wb45naw2	142	21	promote	promote	VBP
cord-314109-wb45naw2	142	22	AMPK	AMPK	NNP
cord-314109-wb45naw2	142	23	activation	activation	NN
cord-314109-wb45naw2	142	24	may	may	MD
cord-314109-wb45naw2	142	25	have	have	VB
cord-314109-wb45naw2	142	26	utility	utility	NN
cord-314109-wb45naw2	142	27	to	to	TO
cord-314109-wb45naw2	142	28	reduce	reduce	VB
cord-314109-wb45naw2	142	29	excessive	excessive	JJ
cord-314109-wb45naw2	142	30	inflammatory	inflammatory	JJ
cord-314109-wb45naw2	142	31	cell	cell	NN
cord-314109-wb45naw2	142	32	activation	activation	NN
cord-314109-wb45naw2	142	33	and	and	CC
cord-314109-wb45naw2	142	34	work	work	NN
cord-314109-wb45naw2	142	35	with	with	IN
cord-314109-wb45naw2	142	36	potential	potential	JJ
cord-314109-wb45naw2	142	37	adjuvant	adjuvant	JJ
cord-314109-wb45naw2	142	38	agents	agent	NNS
cord-314109-wb45naw2	142	39	such	such	JJ
cord-314109-wb45naw2	142	40	as	as	IN
cord-314109-wb45naw2	142	41	hydroxychloroquine	hydroxychloroquine	NNP
cord-314109-wb45naw2	142	42	.	.	.
cord-314109-wb45naw2	143	1	•	•	NNP
cord-314109-wb45naw2	144	1	Yet	yet	CC
cord-314109-wb45naw2	144	2	,	,	,
cord-314109-wb45naw2	144	3	it	-PRON-	PRP
cord-314109-wb45naw2	144	4	is	be	VBZ
cord-314109-wb45naw2	144	5	important	important	JJ
cord-314109-wb45naw2	144	6	to	to	TO
cord-314109-wb45naw2	144	7	recognize	recognize	VB
cord-314109-wb45naw2	144	8	that	that	IN
cord-314109-wb45naw2	144	9	regulation	regulation	NN
cord-314109-wb45naw2	144	10	of	of	IN
cord-314109-wb45naw2	144	11	mTOR	mTOR	NNP
cord-314109-wb45naw2	144	12	activity	activity	NN
cord-314109-wb45naw2	144	13	may	may	MD
cord-314109-wb45naw2	144	14	require	require	VB
cord-314109-wb45naw2	144	15	a	a	DT
cord-314109-wb45naw2	144	16	precise	precise	JJ
cord-314109-wb45naw2	144	17	biological	biological	JJ
cord-314109-wb45naw2	144	18	oversight	oversight	NN
cord-314109-wb45naw2	144	19	.	.	.
cord-314109-wb45naw2	145	1	Activation	activation	NN
cord-314109-wb45naw2	145	2	of	of	IN
cord-314109-wb45naw2	145	3	mTOR	mTOR	NNP
cord-314109-wb45naw2	145	4	pathways	pathway	NNS
cord-314109-wb45naw2	145	5	rather	rather	RB
cord-314109-wb45naw2	145	6	than	than	IN
cord-314109-wb45naw2	145	7	inhibition	inhibition	NN
cord-314109-wb45naw2	145	8	of	of	IN
cord-314109-wb45naw2	145	9	mTOR	mTOR	NNP
cord-314109-wb45naw2	145	10	also	also	RB
cord-314109-wb45naw2	145	11	can	can	MD
cord-314109-wb45naw2	145	12	offer	offer	VB
cord-314109-wb45naw2	145	13	antiviral	antiviral	JJ
cord-314109-wb45naw2	145	14	activity	activity	NN
cord-314109-wb45naw2	145	15	and	and	CC
cord-314109-wb45naw2	145	16	be	be	VB
cord-314109-wb45naw2	145	17	necessary	necessary	JJ
cord-314109-wb45naw2	145	18	for	for	IN
cord-314109-wb45naw2	145	19	anti	anti	JJ
cord-314109-wb45naw2	145	20	-	-	JJ
cord-314109-wb45naw2	145	21	hepatitis	hepatitis	JJ
cord-314109-wb45naw2	145	22	C	c	NN
cord-314109-wb45naw2	145	23	activity	activity	NN
cord-314109-wb45naw2	145	24	,	,	,
cord-314109-wb45naw2	145	25	reduce	reduce	VB
cord-314109-wb45naw2	145	26	influenza	influenza	NN
cord-314109-wb45naw2	145	27	A	a	DT
cord-314109-wb45naw2	145	28	virus	virus	NN
cord-314109-wb45naw2	145	29	replication	replication	NN
cord-314109-wb45naw2	145	30	,	,	,
cord-314109-wb45naw2	145	31	promote	promote	VB
cord-314109-wb45naw2	145	32	natural	natural	JJ
cord-314109-wb45naw2	145	33	killer	killer	NN
cord-314109-wb45naw2	145	34	cell	cell	NN
cord-314109-wb45naw2	145	35	effector	effector	NN
cord-314109-wb45naw2	145	36	function	function	NN
cord-314109-wb45naw2	145	37	,	,	,
cord-314109-wb45naw2	145	38	and	and	CC
cord-314109-wb45naw2	145	39	be	be	VB
cord-314109-wb45naw2	145	40	required	require	VBN
cord-314109-wb45naw2	145	41	for	for	IN
cord-314109-wb45naw2	145	42	type-1	type-1	NN
cord-314109-wb45naw2	145	43	interferon	interferon	NN
cord-314109-wb45naw2	145	44	response	response	NN
cord-314109-wb45naw2	145	45	to	to	TO
cord-314109-wb45naw2	145	46	raise	raise	VB
cord-314109-wb45naw2	145	47	influenza	influenza	NN
cord-314109-wb45naw2	145	48	vaccination	vaccination	NN
cord-314109-wb45naw2	145	49	effectiveness	effectiveness	NN
cord-314109-wb45naw2	145	50	.	.	.
cord-314109-wb45naw2	146	1	•	•	NNP
cord-314109-wb45naw2	147	1	Continued	continue	VBN
cord-314109-wb45naw2	147	2	investigations	investigation	NNS
cord-314109-wb45naw2	147	3	of	of	IN
cord-314109-wb45naw2	147	4	the	the	DT
cord-314109-wb45naw2	147	5	mTOR	mTOR	NNP
cord-314109-wb45naw2	147	6	pathway	pathway	NN
cord-314109-wb45naw2	147	7	as	as	IN
cord-314109-wb45naw2	147	8	a	a	DT
cord-314109-wb45naw2	147	9	potential	potential	JJ
cord-314109-wb45naw2	147	10	antiviral	antiviral	JJ
cord-314109-wb45naw2	147	11	target	target	NN
cord-314109-wb45naw2	147	12	are	be	VBP
cord-314109-wb45naw2	147	13	critical	critical	JJ
cord-314109-wb45naw2	147	14	to	to	TO
cord-314109-wb45naw2	147	15	further	further	RB
cord-314109-wb45naw2	147	16	unravel	unravel	VB
cord-314109-wb45naw2	147	17	the	the	DT
cord-314109-wb45naw2	147	18	insights	insight	NNS
cord-314109-wb45naw2	147	19	required	require	VBN
cord-314109-wb45naw2	147	20	to	to	TO
cord-314109-wb45naw2	147	21	translate	translate	VB
cord-314109-wb45naw2	147	22	mTOR	mTOR	NNP
cord-314109-wb45naw2	147	23	pathways	pathway	NNS
cord-314109-wb45naw2	147	24	into	into	IN
cord-314109-wb45naw2	147	25	clinical	clinical	JJ
cord-314109-wb45naw2	147	26	strategies	strategy	NNS
cord-314109-wb45naw2	147	27	that	that	WDT
cord-314109-wb45naw2	147	28	can	can	MD
cord-314109-wb45naw2	147	29	potentially	potentially	RB
cord-314109-wb45naw2	147	30	block	block	VB
cord-314109-wb45naw2	147	31	viral	viral	JJ
cord-314109-wb45naw2	147	32	infection	infection	NN
cord-314109-wb45naw2	147	33	and	and	CC
cord-314109-wb45naw2	147	34	overcome	overcome	VB
cord-314109-wb45naw2	147	35	systemic	systemic	JJ
cord-314109-wb45naw2	147	36	illness	illness	NN
cord-314109-wb45naw2	147	37	that	that	WDT
cord-314109-wb45naw2	147	38	can	can	MD
cord-314109-wb45naw2	147	39	be	be	VB
cord-314109-wb45naw2	147	40	associated	associate	VBN
cord-314109-wb45naw2	147	41	with	with	IN
cord-314109-wb45naw2	147	42	virions	virion	NNS
cord-314109-wb45naw2	147	43	such	such	JJ
cord-314109-wb45naw2	147	44	as	as	IN
cord-314109-wb45naw2	147	45	SARS	SARS	NNP
cord-314109-wb45naw2	147	46	-	-	HYPH
cord-314109-wb45naw2	147	47	CoV-2	CoV-2	NNP
cord-314109-wb45naw2	147	48	.	.	.
cord-314109-wb45naw2	148	1	Novel	novel	JJ
cord-314109-wb45naw2	148	2	Coronavirus	Coronavirus	NNP
cord-314109-wb45naw2	148	3	infection	infection	NN
cord-314109-wb45naw2	148	4	(	(	-LRB-
cord-314109-wb45naw2	148	5	COVID-19	covid-19	VB
cord-314109-wb45naw2	148	6	)	)	-RRB-
cord-314109-wb45naw2	148	7	in	in	IN
cord-314109-wb45naw2	148	8	humans	human	NNS
cord-314109-wb45naw2	148	9	:	:	:
cord-314109-wb45naw2	149	1	A	a	DT
cord-314109-wb45naw2	149	2	scoping	scoping	NN
cord-314109-wb45naw2	149	3	review	review	NN
cord-314109-wb45naw2	149	4	and	and	CC
cord-314109-wb45naw2	149	5	meta	meta	NNP
cord-314109-wb45naw2	149	6	-	-	HYPH
cord-314109-wb45naw2	149	7	analysis	analysis	NN
cord-314109-wb45naw2	149	8	Coronavirus	Coronavirus	NNP
cord-314109-wb45naw2	149	9	disease	disease	NN
cord-314109-wb45naw2	149	10	2019	2019	CD
cord-314109-wb45naw2	150	1	(	(	-LRB-
cord-314109-wb45naw2	150	2	COVID-19	COVID-19	NNP
cord-314109-wb45naw2	150	3	)	)	-RRB-
cord-314109-wb45naw2	150	4	:	:	:
cord-314109-wb45naw2	151	1	A	a	DT
cord-314109-wb45naw2	151	2	clinical	clinical	JJ
cord-314109-wb45naw2	151	3	update	update	NN
cord-314109-wb45naw2	151	4	World	World	NNP
cord-314109-wb45naw2	151	5	Health	Health	NNP
cord-314109-wb45naw2	151	6	Organization	Organization	NNP
cord-314109-wb45naw2	151	7	.	.	.
cord-314109-wb45naw2	152	1	WHO	who	WP
cord-314109-wb45naw2	152	2	Situation	Situation	NNP
cord-314109-wb45naw2	152	3	Report	Report	NNP
cord-314109-wb45naw2	152	4	#	#	$
cord-314109-wb45naw2	152	5	65	65	CD
cord-314109-wb45naw2	152	6	.	.	.
cord-314109-wb45naw2	153	1	Geneva	Geneva	NNP
cord-314109-wb45naw2	153	2	:	:	:
cord-314109-wb45naw2	154	1	World	World	NNP
cord-314109-wb45naw2	154	2	Health	Health	NNP
cord-314109-wb45naw2	154	3	Organization	Organization	NNP
cord-314109-wb45naw2	154	4	Impact	Impact	NNP
cord-314109-wb45naw2	154	5	of	of	IN
cord-314109-wb45naw2	154	6	school	school	NN
cord-314109-wb45naw2	154	7	closures	closure	NNS
cord-314109-wb45naw2	154	8	for	for	IN
cord-314109-wb45naw2	154	9	COVID-19	covid-19	NN
cord-314109-wb45naw2	154	10	on	on	IN
cord-314109-wb45naw2	154	11	the	the	DT
cord-314109-wb45naw2	154	12	US	US	NNP
cord-314109-wb45naw2	154	13	health	health	NN
cord-314109-wb45naw2	154	14	-	-	HYPH
cord-314109-wb45naw2	154	15	care	care	NN
cord-314109-wb45naw2	154	16	workforce	workforce	NN
cord-314109-wb45naw2	154	17	and	and	CC
cord-314109-wb45naw2	154	18	net	net	JJ
cord-314109-wb45naw2	154	19	mortality	mortality	NN
cord-314109-wb45naw2	154	20	:	:	:
cord-314109-wb45naw2	155	1	A	a	DT
cord-314109-wb45naw2	155	2	modelling	modelling	NN
cord-314109-wb45naw2	155	3	study	study	NN
cord-314109-wb45naw2	155	4	SARS	SARS	NNP
cord-314109-wb45naw2	155	5	-	-	HYPH
cord-314109-wb45naw2	155	6	CoV-2	CoV-2	NNP
cord-314109-wb45naw2	155	7	entry	entry	NN
cord-314109-wb45naw2	155	8	factors	factor	NNS
cord-314109-wb45naw2	155	9	are	be	VBP
cord-314109-wb45naw2	155	10	highly	highly	RB
cord-314109-wb45naw2	155	11	expressed	express	VBN
cord-314109-wb45naw2	155	12	in	in	IN
cord-314109-wb45naw2	155	13	nasal	nasal	JJ
cord-314109-wb45naw2	155	14	epithelial	epithelial	JJ
cord-314109-wb45naw2	155	15	cells	cell	NNS
cord-314109-wb45naw2	155	16	together	together	RB
cord-314109-wb45naw2	155	17	with	with	IN
cord-314109-wb45naw2	155	18	innate	innate	JJ
cord-314109-wb45naw2	155	19	immune	immune	JJ
cord-314109-wb45naw2	155	20	genes	gene	NNS
cord-314109-wb45naw2	156	1	The	the	DT
cord-314109-wb45naw2	156	2	Role	role	NN
cord-314109-wb45naw2	156	3	of	of	IN
cord-314109-wb45naw2	156	4	Cytokines	Cytokines	NNPS
cord-314109-wb45naw2	156	5	including	include	VBG
cord-314109-wb45naw2	156	6	Interleukin-6	Interleukin-6	NNP
cord-314109-wb45naw2	156	7	in	in	IN
cord-314109-wb45naw2	156	8	COVID-19	COVID-19	NNP
cord-314109-wb45naw2	156	9	induced	induce	VBN
cord-314109-wb45naw2	156	10	Pneumonia	Pneumonia	NNP
cord-314109-wb45naw2	156	11	and	and	CC
cord-314109-wb45naw2	156	12	Macrophage	Macrophage	NNP
cord-314109-wb45naw2	156	13	Activation	Activation	NNP
cord-314109-wb45naw2	156	14	Syndrome	Syndrome	NNP
cord-314109-wb45naw2	156	15	-	-	HYPH
cord-314109-wb45naw2	156	16	Like	Like	NNP
cord-314109-wb45naw2	156	17	Disease	Disease	NNP
cord-314109-wb45naw2	156	18	Induction	Induction	NNP
cord-314109-wb45naw2	156	19	of	of	IN
cord-314109-wb45naw2	156	20	proinflammatory	proinflammatory	JJ
cord-314109-wb45naw2	156	21	cytokines	cytokine	NNS
cord-314109-wb45naw2	156	22	(	(	-LRB-
cord-314109-wb45naw2	156	23	IL-1	IL-1	NNP
cord-314109-wb45naw2	156	24	and	and	CC
cord-314109-wb45naw2	156	25	IL-6	IL-6	NNP
cord-314109-wb45naw2	156	26	)	)	-RRB-
cord-314109-wb45naw2	156	27	and	and	CC
cord-314109-wb45naw2	156	28	lung	lung	NN
cord-314109-wb45naw2	156	29	inflammation	inflammation	NN
cord-314109-wb45naw2	156	30	by	by	IN
cord-314109-wb45naw2	156	31	Coronavirus-19	Coronavirus-19	NNP
cord-314109-wb45naw2	156	32	(	(	-LRB-
cord-314109-wb45naw2	156	33	COVI-19	COVI-19	NNP
cord-314109-wb45naw2	156	34	or	or	CC
cord-314109-wb45naw2	156	35	SARS	SARS	NNP
cord-314109-wb45naw2	156	36	-	-	HYPH
cord-314109-wb45naw2	156	37	CoV-2	CoV-2	NNP
cord-314109-wb45naw2	156	38	)	)	-RRB-
cord-314109-wb45naw2	156	39	:	:	:
cord-314109-wb45naw2	156	40	anti	anti	JJ
cord-314109-wb45naw2	156	41	-	-	JJ
cord-314109-wb45naw2	156	42	inflammatory	inflammatory	JJ
cord-314109-wb45naw2	156	43	strategies	strategy	NNS
cord-314109-wb45naw2	156	44	Prevalence	prevalence	NN
cord-314109-wb45naw2	156	45	and	and	CC
cord-314109-wb45naw2	156	46	impact	impact	NN
cord-314109-wb45naw2	156	47	of	of	IN
cord-314109-wb45naw2	156	48	diabetes	diabetes	NN
cord-314109-wb45naw2	156	49	among	among	IN
cord-314109-wb45naw2	156	50	people	people	NNS
cord-314109-wb45naw2	156	51	infected	infect	VBN
cord-314109-wb45naw2	156	52	with	with	IN
cord-314109-wb45naw2	156	53	SARS	SARS	NNP
cord-314109-wb45naw2	156	54	-	-	HYPH
cord-314109-wb45naw2	156	55	CoV-2	CoV-2	NNP
cord-314109-wb45naw2	156	56	Deployment	Deployment	NNP
cord-314109-wb45naw2	156	57	of	of	IN
cord-314109-wb45naw2	156	58	convalescent	convalescent	JJ
cord-314109-wb45naw2	156	59	plasma	plasma	NN
cord-314109-wb45naw2	156	60	for	for	IN
cord-314109-wb45naw2	156	61	the	the	DT
cord-314109-wb45naw2	156	62	prevention	prevention	NN
cord-314109-wb45naw2	156	63	and	and	CC
cord-314109-wb45naw2	156	64	treatment	treatment	NN
cord-314109-wb45naw2	156	65	of	of	IN
cord-314109-wb45naw2	156	66	COVID-19	COVID-19	NNP
cord-314109-wb45naw2	156	67	SARS	SARS	NNP
cord-314109-wb45naw2	156	68	-	-	HYPH
cord-314109-wb45naw2	156	69	CoV-2	CoV-2	NNP
cord-314109-wb45naw2	157	1	Vaccines	vaccine	NNS
cord-314109-wb45naw2	157	2	:	:	:
cord-314109-wb45naw2	157	3	Status	Status	NNP
cord-314109-wb45naw2	157	4	Report	Report	NNP
cord-314109-wb45naw2	157	5	Repurposing	repurposing	NN
cord-314109-wb45naw2	157	6	of	of	IN
cord-314109-wb45naw2	157	7	clinically	clinically	RB
cord-314109-wb45naw2	157	8	approved	approve	VBN
cord-314109-wb45naw2	157	9	drugs	drug	NNS
cord-314109-wb45naw2	157	10	for	for	IN
cord-314109-wb45naw2	157	11	treatment	treatment	NN
cord-314109-wb45naw2	157	12	of	of	IN
cord-314109-wb45naw2	157	13	coronavirus	coronavirus	NN
cord-314109-wb45naw2	157	14	disease	disease	NN
cord-314109-wb45naw2	157	15	2019	2019	CD
cord-314109-wb45naw2	157	16	in	in	IN
cord-314109-wb45naw2	157	17	a	a	DT
cord-314109-wb45naw2	157	18	2019-novel	2019-novel	CD
cord-314109-wb45naw2	157	19	coronavirus	coronavirus	NN
cord-314109-wb45naw2	157	20	(	(	-LRB-
cord-314109-wb45naw2	157	21	2019-nCoV	2019-ncov	CD
cord-314109-wb45naw2	157	22	)	)	-RRB-
cord-314109-wb45naw2	157	23	related	related	JJ
cord-314109-wb45naw2	157	24	coronavirus	coronavirus	NN
cord-314109-wb45naw2	157	25	model	model	NN
cord-314109-wb45naw2	157	26	a	a	DT
cord-314109-wb45naw2	157	27	systems	system	NNS
cord-314109-wb45naw2	157	28	biology	biology	NN
cord-314109-wb45naw2	157	29	roadmap	roadmap	NN
cord-314109-wb45naw2	157	30	to	to	TO
cord-314109-wb45naw2	157	31	decode	decode	VB
cord-314109-wb45naw2	157	32	mTOR	mTOR	NNP
cord-314109-wb45naw2	157	33	control	control	NN
cord-314109-wb45naw2	157	34	system	system	NN
cord-314109-wb45naw2	157	35	in	in	IN
cord-314109-wb45naw2	157	36	cancer	cancer	NN
cord-314109-wb45naw2	157	37	Cognitive	cognitive	JJ
cord-314109-wb45naw2	157	38	impairment	impairment	NN
cord-314109-wb45naw2	157	39	with	with	IN
cord-314109-wb45naw2	157	40	diabetes	diabetes	NN
cord-314109-wb45naw2	157	41	mellitus	mellitus	NN
cord-314109-wb45naw2	157	42	and	and	CC
cord-314109-wb45naw2	157	43	metabolic	metabolic	JJ
cord-314109-wb45naw2	157	44	disease	disease	NN
cord-314109-wb45naw2	157	45	:	:	:
cord-314109-wb45naw2	158	1	innovative	innovative	JJ
cord-314109-wb45naw2	158	2	insights	insight	NNS
cord-314109-wb45naw2	158	3	with	with	IN
cord-314109-wb45naw2	158	4	the	the	DT
cord-314109-wb45naw2	158	5	mechanistic	mechanistic	JJ
cord-314109-wb45naw2	158	6	target	target	NN
cord-314109-wb45naw2	158	7	of	of	IN
cord-314109-wb45naw2	158	8	rapamycin	rapamycin	NN
cord-314109-wb45naw2	158	9	and	and	CC
cord-314109-wb45naw2	158	10	circadian	circadian	NN
cord-314109-wb45naw2	158	11	clock	clock	NN
cord-314109-wb45naw2	158	12	gene	gene	NN
cord-314109-wb45naw2	158	13	pathways	pathway	NNS
cord-314109-wb45naw2	158	14	mTOR	mTOR	NNP
cord-314109-wb45naw2	158	15	may	may	MD
cord-314109-wb45naw2	158	16	interact	interact	VB
cord-314109-wb45naw2	158	17	with	with	IN
cord-314109-wb45naw2	158	18	PARP-1	PARP-1	NNS
cord-314109-wb45naw2	158	19	to	to	TO
cord-314109-wb45naw2	158	20	regulate	regulate	VB
cord-314109-wb45naw2	158	21	visible	visible	JJ
cord-314109-wb45naw2	158	22	light	light	NN
cord-314109-wb45naw2	158	23	-	-	HYPH
cord-314109-wb45naw2	158	24	induced	induce	VBN
cord-314109-wb45naw2	158	25	parthanatos	parthanatos	NN
cord-314109-wb45naw2	158	26	in	in	IN
cord-314109-wb45naw2	158	27	photoreceptors	photoreceptor	NNS
cord-314109-wb45naw2	158	28	Roles	role	NNS
cord-314109-wb45naw2	158	29	of	of	IN
cord-314109-wb45naw2	158	30	the	the	DT
cord-314109-wb45naw2	158	31	PI3K	PI3K	NNP
cord-314109-wb45naw2	158	32	/	/	SYM
cord-314109-wb45naw2	158	33	AKT	AKT	NNP
cord-314109-wb45naw2	158	34	/	/	SYM
cord-314109-wb45naw2	158	35	mTOR	mtor	NN
cord-314109-wb45naw2	158	36	signalling	signal	VBG
cord-314109-wb45naw2	158	37	pathways	pathway	NNS
cord-314109-wb45naw2	158	38	in	in	IN
cord-314109-wb45naw2	158	39	neurodegenerative	neurodegenerative	JJ
cord-314109-wb45naw2	158	40	diseases	disease	NNS
cord-314109-wb45naw2	158	41	and	and	CC
cord-314109-wb45naw2	158	42	tumours	tumour	NNS
cord-314109-wb45naw2	159	1	Targeting	target	VBG
cord-314109-wb45naw2	159	2	molecules	molecule	NNS
cord-314109-wb45naw2	159	3	to	to	IN
cord-314109-wb45naw2	159	4	medicine	medicine	NN
cord-314109-wb45naw2	159	5	with	with	IN
cord-314109-wb45naw2	159	6	mTOR	mTOR	NNP
cord-314109-wb45naw2	159	7	,	,	,
cord-314109-wb45naw2	159	8	autophagy	autophagy	NN
cord-314109-wb45naw2	159	9	and	and	CC
cord-314109-wb45naw2	159	10	neurodegenerative	neurodegenerative	JJ
cord-314109-wb45naw2	159	11	disorders	disorder	NNS
cord-314109-wb45naw2	159	12	Novel	novel	VBP
cord-314109-wb45naw2	159	13	nervous	nervous	JJ
cord-314109-wb45naw2	159	14	and	and	CC
cord-314109-wb45naw2	159	15	multi	multi	JJ
cord-314109-wb45naw2	159	16	-	-	JJ
cord-314109-wb45naw2	159	17	system	system	JJ
cord-314109-wb45naw2	159	18	regenerative	regenerative	JJ
cord-314109-wb45naw2	159	19	therapeutic	therapeutic	JJ
cord-314109-wb45naw2	159	20	strategies	strategy	NNS
cord-314109-wb45naw2	159	21	for	for	IN
cord-314109-wb45naw2	159	22	diabetes	diabetes	NN
cord-314109-wb45naw2	159	23	mellitus	mellitus	NN
cord-314109-wb45naw2	159	24	with	with	IN
cord-314109-wb45naw2	159	25	mTOR	mTOR	NNP
cord-314109-wb45naw2	159	26	mTOR	mTOR	NNP
cord-314109-wb45naw2	159	27	:	:	:
cord-314109-wb45naw2	159	28	on	on	IN
cord-314109-wb45naw2	159	29	target	target	NN
cord-314109-wb45naw2	159	30	for	for	IN
cord-314109-wb45naw2	159	31	novel	novel	JJ
cord-314109-wb45naw2	159	32	therapeutic	therapeutic	JJ
cord-314109-wb45naw2	159	33	strategies	strategy	NNS
cord-314109-wb45naw2	159	34	in	in	IN
cord-314109-wb45naw2	159	35	the	the	DT
cord-314109-wb45naw2	159	36	nervous	nervous	JJ
cord-314109-wb45naw2	159	37	system	system	NN
cord-314109-wb45naw2	159	38	Reversal	reversal	NN
cord-314109-wb45naw2	159	39	of	of	IN
cord-314109-wb45naw2	159	40	phenotypes	phenotype	NNS
cord-314109-wb45naw2	159	41	of	of	IN
cord-314109-wb45naw2	159	42	cellular	cellular	JJ
cord-314109-wb45naw2	159	43	senescence	senescence	NN
cord-314109-wb45naw2	159	44	by	by	IN
cord-314109-wb45naw2	159	45	pan	pan	JJ
cord-314109-wb45naw2	159	46	-	-	JJ
cord-314109-wb45naw2	159	47	mTOR	mtor	JJ
cord-314109-wb45naw2	159	48	inhibition	inhibition	NN
cord-314109-wb45naw2	160	1	The	the	DT
cord-314109-wb45naw2	160	2	mechanistic	mechanistic	JJ
cord-314109-wb45naw2	160	3	target	target	NN
cord-314109-wb45naw2	160	4	of	of	IN
cord-314109-wb45naw2	160	5	rapamycin	rapamycin	NNP
cord-314109-wb45naw2	160	6	(	(	-LRB-
cord-314109-wb45naw2	160	7	mTOR	mTOR	NNP
cord-314109-wb45naw2	160	8	)	)	-RRB-
cord-314109-wb45naw2	160	9	and	and	CC
cord-314109-wb45naw2	160	10	the	the	DT
cord-314109-wb45naw2	160	11	silent	silent	JJ
cord-314109-wb45naw2	160	12	mating	mating	NN
cord-314109-wb45naw2	160	13	-	-	HYPH
cord-314109-wb45naw2	160	14	type	type	NN
cord-314109-wb45naw2	160	15	information	information	NN
cord-314109-wb45naw2	160	16	regulation	regulation	NN
cord-314109-wb45naw2	160	17	2	2	CD
cord-314109-wb45naw2	160	18	homolog	homolog	NN
cord-314109-wb45naw2	160	19	1	1	CD
cord-314109-wb45naw2	160	20	(	(	-LRB-
cord-314109-wb45naw2	160	21	SIRT1	SIRT1	NNP
cord-314109-wb45naw2	160	22	)	)	-RRB-
cord-314109-wb45naw2	160	23	:	:	:
cord-314109-wb45naw2	160	24	Oversight	oversight	NN
cord-314109-wb45naw2	160	25	for	for	IN
cord-314109-wb45naw2	160	26	neurodegenerative	neurodegenerative	JJ
cord-314109-wb45naw2	160	27	disorders	disorder	NNS
cord-314109-wb45naw2	160	28	Role	role	NN
cord-314109-wb45naw2	160	29	of	of	IN
cord-314109-wb45naw2	160	30	mTOR	mTOR	NNP
cord-314109-wb45naw2	160	31	complex	complex	NN
cord-314109-wb45naw2	160	32	in	in	IN
cord-314109-wb45naw2	160	33	IGF-1	IGF-1	NNP
cord-314109-wb45naw2	161	1	induced	induce	VBN
cord-314109-wb45naw2	161	2	neural	neural	JJ
cord-314109-wb45naw2	161	3	differentiation	differentiation	NN
cord-314109-wb45naw2	161	4	of	of	IN
cord-314109-wb45naw2	161	5	DPSCs	DPSCs	NNP
cord-314109-wb45naw2	161	6	Novel	Novel	NNP
cord-314109-wb45naw2	161	7	treatment	treatment	NN
cord-314109-wb45naw2	161	8	strategies	strategy	NNS
cord-314109-wb45naw2	161	9	for	for	IN
cord-314109-wb45naw2	161	10	the	the	DT
cord-314109-wb45naw2	161	11	nervous	nervous	JJ
cord-314109-wb45naw2	161	12	system	system	NN
cord-314109-wb45naw2	161	13	:	:	:
cord-314109-wb45naw2	161	14	circadian	circadian	NN
cord-314109-wb45naw2	161	15	clock	clock	NN
cord-314109-wb45naw2	161	16	genes	gene	NNS
cord-314109-wb45naw2	161	17	,	,	,
cord-314109-wb45naw2	161	18	non	non	JJ
cord-314109-wb45naw2	161	19	-	-	JJ
cord-314109-wb45naw2	161	20	coding	coding	JJ
cord-314109-wb45naw2	161	21	RNAs	rna	NNS
cord-314109-wb45naw2	161	22	,	,	,
cord-314109-wb45naw2	161	23	and	and	CC
cord-314109-wb45naw2	162	1	forkhead	forkhead	NNP
cord-314109-wb45naw2	162	2	transcription	transcription	NN
cord-314109-wb45naw2	162	3	factors	factor	NNS
cord-314109-wb45naw2	162	4	Therapeutic	therapeutic	JJ
cord-314109-wb45naw2	162	5	potency	potency	NN
cord-314109-wb45naw2	162	6	of	of	IN
cord-314109-wb45naw2	162	7	mTOR	mTOR	NNP
cord-314109-wb45naw2	162	8	signaling	signal	VBG
cord-314109-wb45naw2	162	9	pharmacological	pharmacological	JJ
cord-314109-wb45naw2	162	10	inhibitors	inhibitor	NNS
cord-314109-wb45naw2	162	11	in	in	IN
cord-314109-wb45naw2	162	12	the	the	DT
cord-314109-wb45naw2	162	13	treatment	treatment	NN
cord-314109-wb45naw2	162	14	of	of	IN
cord-314109-wb45naw2	162	15	proinflammatory	proinflammatory	JJ
cord-314109-wb45naw2	162	16	diseases	disease	NNS
cord-314109-wb45naw2	162	17	,	,	,
cord-314109-wb45naw2	162	18	current	current	JJ
cord-314109-wb45naw2	162	19	status	status	NN
cord-314109-wb45naw2	162	20	and	and	CC
cord-314109-wb45naw2	162	21	perspectives	perspective	NNS
cord-314109-wb45naw2	162	22	Rapamycin	Rapamycin	NNP
cord-314109-wb45naw2	162	23	treatment	treatment	NN
cord-314109-wb45naw2	162	24	increases	increase	VBZ
cord-314109-wb45naw2	162	25	hippocampal	hippocampal	JJ
cord-314109-wb45naw2	162	26	cell	cell	NN
cord-314109-wb45naw2	162	27	viability	viability	NN
cord-314109-wb45naw2	162	28	in	in	IN
cord-314109-wb45naw2	162	29	an	an	DT
cord-314109-wb45naw2	162	30	mTOR	mtor	JJ
cord-314109-wb45naw2	162	31	-	-	HYPH
cord-314109-wb45naw2	162	32	independent	independent	JJ
cord-314109-wb45naw2	162	33	manner	manner	NN
cord-314109-wb45naw2	162	34	during	during	IN
cord-314109-wb45naw2	162	35	exposure	exposure	NN
cord-314109-wb45naw2	162	36	to	to	IN
cord-314109-wb45naw2	162	37	hypoxia	hypoxia	NN
cord-314109-wb45naw2	162	38	mimetic	mimetic	NN
cord-314109-wb45naw2	163	1	,	,	,
cord-314109-wb45naw2	163	2	cobalt	cobalt	NN
cord-314109-wb45naw2	163	3	chloride	chloride	NN
cord-314109-wb45naw2	163	4	Mammalian	mammalian	JJ
cord-314109-wb45naw2	163	5	target	target	NN
cord-314109-wb45naw2	163	6	of	of	IN
cord-314109-wb45naw2	163	7	rapamycin	rapamycin	NN
cord-314109-wb45naw2	163	8	complex	complex	NNP
cord-314109-wb45naw2	163	9	1	1	CD
cord-314109-wb45naw2	163	10	(	(	-LRB-
cord-314109-wb45naw2	163	11	mTORC1	mtorc1	NN
cord-314109-wb45naw2	163	12	)	)	-RRB-
cord-314109-wb45naw2	163	13	activity	activity	NN
cord-314109-wb45naw2	163	14	is	be	VBZ
cord-314109-wb45naw2	163	15	associated	associate	VBN
cord-314109-wb45naw2	163	16	with	with	IN
cord-314109-wb45naw2	163	17	phosphorylation	phosphorylation	NN
cord-314109-wb45naw2	163	18	of	of	IN
cord-314109-wb45naw2	163	19	raptor	raptor	NN
cord-314109-wb45naw2	163	20	by	by	IN
cord-314109-wb45naw2	163	21	mTOR	mTOR	NNP
cord-314109-wb45naw2	163	22	Time	Time	NNP
cord-314109-wb45naw2	163	23	-	-	HYPH
cord-314109-wb45naw2	163	24	of	of	IN
cord-314109-wb45naw2	163	25	-	-	HYPH
cord-314109-wb45naw2	163	26	day	day	NN
cord-314109-wb45naw2	163	27	dependent	dependent	JJ
cord-314109-wb45naw2	163	28	neuronal	neuronal	JJ
cord-314109-wb45naw2	163	29	injury	injury	NN
cord-314109-wb45naw2	163	30	after	after	IN
cord-314109-wb45naw2	163	31	ischemic	ischemic	JJ
cord-314109-wb45naw2	163	32	stroke	stroke	NN
cord-314109-wb45naw2	163	33	:	:	:
cord-314109-wb45naw2	163	34	Implication	implication	NN
cord-314109-wb45naw2	163	35	of	of	IN
cord-314109-wb45naw2	163	36	circadian	circadian	NN
cord-314109-wb45naw2	163	37	clock	clock	NN
cord-314109-wb45naw2	163	38	transcriptional	transcriptional	JJ
cord-314109-wb45naw2	163	39	factor	factor	NN
cord-314109-wb45naw2	163	40	bmal1	bmal1	RB
cord-314109-wb45naw2	163	41	and	and	CC
cord-314109-wb45naw2	163	42	survival	survival	NN
cord-314109-wb45naw2	164	1	kinase	kinase	VBZ
cord-314109-wb45naw2	164	2	AKT	AKT	NNP
cord-314109-wb45naw2	164	3	PRAS40	PRAS40	NNP
cord-314109-wb45naw2	164	4	Is	be	VBZ
cord-314109-wb45naw2	164	5	an	an	DT
cord-314109-wb45naw2	164	6	integral	integral	JJ
cord-314109-wb45naw2	164	7	regulatory	regulatory	JJ
cord-314109-wb45naw2	164	8	component	component	NN
cord-314109-wb45naw2	164	9	of	of	IN
cord-314109-wb45naw2	164	10	erythropoietin	erythropoietin	NNP
cord-314109-wb45naw2	164	11	mTOR	mTOR	NNP
cord-314109-wb45naw2	164	12	signaling	signaling	NN
cord-314109-wb45naw2	164	13	and	and	CC
cord-314109-wb45naw2	164	14	cytoprotection	cytoprotection	NN
cord-314109-wb45naw2	164	15	Regulation	Regulation	NNP
cord-314109-wb45naw2	164	16	of	of	IN
cord-314109-wb45naw2	164	17	proline	proline	JJ
cord-314109-wb45naw2	164	18	-	-	HYPH
cord-314109-wb45naw2	164	19	rich	rich	JJ
cord-314109-wb45naw2	164	20	Akt	Akt	NNP
cord-314109-wb45naw2	164	21	substrate	substrate	NN
cord-314109-wb45naw2	164	22	of	of	IN
cord-314109-wb45naw2	164	23	40	40	CD
cord-314109-wb45naw2	164	24	kDa	kDa	NNS
cord-314109-wb45naw2	164	25	(	(	-LRB-
cord-314109-wb45naw2	164	26	PRAS40	PRAS40	NNP
cord-314109-wb45naw2	164	27	)	)	-RRB-
cord-314109-wb45naw2	164	28	function	function	VB
cord-314109-wb45naw2	164	29	by	by	IN
cord-314109-wb45naw2	164	30	mammalian	mammalian	JJ
cord-314109-wb45naw2	164	31	target	target	NN
cord-314109-wb45naw2	164	32	of	of	IN
cord-314109-wb45naw2	164	33	rapamycin	rapamycin	NN
cord-314109-wb45naw2	164	34	complex	complex	NNP
cord-314109-wb45naw2	164	35	1	1	CD
cord-314109-wb45naw2	164	36	(	(	-LRB-
cord-314109-wb45naw2	164	37	mTORC1)-mediated	mtorc1)-mediate	VBN
cord-314109-wb45naw2	164	38	phosphorylation	phosphorylation	NN
cord-314109-wb45naw2	164	39	WNT1	WNT1	NNP
cord-314109-wb45naw2	164	40	Inducible	Inducible	NNP
cord-314109-wb45naw2	164	41	Signaling	Signaling	NNP
cord-314109-wb45naw2	164	42	Pathway	Pathway	NNP
cord-314109-wb45naw2	164	43	Protein	Protein	NNP
cord-314109-wb45naw2	164	44	1	1	CD
cord-314109-wb45naw2	164	45	(	(	-LRB-
cord-314109-wb45naw2	164	46	WISP1	wisp1	NN
cord-314109-wb45naw2	164	47	)	)	-RRB-
cord-314109-wb45naw2	164	48	targets	target	VBZ
cord-314109-wb45naw2	164	49	PRAS40	pras40	VBP
cord-314109-wb45naw2	164	50	to	to	TO
cord-314109-wb45naw2	164	51	govern	govern	VB
cord-314109-wb45naw2	164	52	beta	beta	NN
cord-314109-wb45naw2	164	53	-	-	HYPH
cord-314109-wb45naw2	164	54	amyloid	amyloid	NN
cord-314109-wb45naw2	164	55	apoptotic	apoptotic	JJ
cord-314109-wb45naw2	164	56	injury	injury	NN
cord-314109-wb45naw2	164	57	of	of	IN
cord-314109-wb45naw2	164	58	microglia	microglia	JJ
cord-314109-wb45naw2	164	59	Proline	proline	NN
cord-314109-wb45naw2	164	60	-	-	HYPH
cord-314109-wb45naw2	164	61	rich	rich	JJ
cord-314109-wb45naw2	164	62	Akt	Akt	NNP
cord-314109-wb45naw2	164	63	substrate	substrate	NN
cord-314109-wb45naw2	164	64	of	of	IN
cord-314109-wb45naw2	164	65	40kDa	40kda	CD
cord-314109-wb45naw2	165	1	(	(	-LRB-
cord-314109-wb45naw2	165	2	PRAS40	pras40	NN
cord-314109-wb45naw2	165	3	)	)	-RRB-
cord-314109-wb45naw2	165	4	:	:	:
cord-314109-wb45naw2	165	5	A	a	DT
cord-314109-wb45naw2	165	6	novel	novel	JJ
cord-314109-wb45naw2	165	7	downstream	downstream	JJ
cord-314109-wb45naw2	165	8	target	target	NN
cord-314109-wb45naw2	165	9	of	of	IN
cord-314109-wb45naw2	165	10	PI3k	PI3k	NNP
cord-314109-wb45naw2	165	11	/	/	SYM
cord-314109-wb45naw2	165	12	Akt	Akt	NNP
cord-314109-wb45naw2	165	13	signaling	signal	VBG
cord-314109-wb45naw2	165	14	pathway	pathway	NN
cord-314109-wb45naw2	165	15	mTOR	mtor	NN
cord-314109-wb45naw2	165	16	Drives	drive	VBZ
cord-314109-wb45naw2	165	17	Its	-PRON-	PRP$
cord-314109-wb45naw2	165	18	Own	own	JJ
cord-314109-wb45naw2	165	19	Activation	activation	NN
cord-314109-wb45naw2	165	20	via	via	IN
cord-314109-wb45naw2	165	21	SCF(betaTrCP)-Dependent	scf(betatrcp)-dependent	NN
cord-314109-wb45naw2	165	22	Degradation	degradation	NN
cord-314109-wb45naw2	165	23	of	of	IN
cord-314109-wb45naw2	165	24	the	the	DT
cord-314109-wb45naw2	165	25	mTOR	mtor	NN
cord-314109-wb45naw2	165	26	Inhibitor	Inhibitor	NNP
cord-314109-wb45naw2	165	27	DEPTOR	DEPTOR	NNP
cord-314109-wb45naw2	165	28	GbetaL	GbetaL	NNP
cord-314109-wb45naw2	165	29	,	,	,
cord-314109-wb45naw2	165	30	a	a	DT
cord-314109-wb45naw2	165	31	positive	positive	JJ
cord-314109-wb45naw2	165	32	regulator	regulator	NN
cord-314109-wb45naw2	165	33	of	of	IN
cord-314109-wb45naw2	165	34	the	the	DT
cord-314109-wb45naw2	165	35	rapamycin	rapamycin	NN
cord-314109-wb45naw2	165	36	-	-	HYPH
cord-314109-wb45naw2	165	37	sensitive	sensitive	JJ
cord-314109-wb45naw2	165	38	pathway	pathway	NN
cord-314109-wb45naw2	165	39	required	require	VBN
cord-314109-wb45naw2	165	40	for	for	IN
cord-314109-wb45naw2	165	41	the	the	DT
cord-314109-wb45naw2	165	42	nutrientsensitive	nutrientsensitive	JJ
cord-314109-wb45naw2	165	43	interaction	interaction	NN
cord-314109-wb45naw2	165	44	between	between	IN
cord-314109-wb45naw2	165	45	raptor	raptor	NNP
cord-314109-wb45naw2	165	46	and	and	CC
cord-314109-wb45naw2	165	47	mTOR	mTOR	NNP
cord-314109-wb45naw2	165	48	Impacting	Impacting	NNP
cord-314109-wb45naw2	165	49	dementia	dementia	NN
cord-314109-wb45naw2	165	50	and	and	CC
cord-314109-wb45naw2	165	51	cognitive	cognitive	JJ
cord-314109-wb45naw2	165	52	loss	loss	NN
cord-314109-wb45naw2	165	53	with	with	IN
cord-314109-wb45naw2	165	54	innovative	innovative	JJ
cord-314109-wb45naw2	165	55	strategies	strategy	NNS
cord-314109-wb45naw2	165	56	:	:	:
cord-314109-wb45naw2	165	57	mechanistic	mechanistic	JJ
cord-314109-wb45naw2	165	58	target	target	NN
cord-314109-wb45naw2	165	59	of	of	IN
cord-314109-wb45naw2	165	60	rapamycin	rapamycin	NN
cord-314109-wb45naw2	165	61	,	,	,
cord-314109-wb45naw2	165	62	clock	clock	NN
cord-314109-wb45naw2	165	63	genes	gene	NNS
cord-314109-wb45naw2	165	64	,	,	,
cord-314109-wb45naw2	165	65	circular	circular	JJ
cord-314109-wb45naw2	165	66	non	non	JJ
cord-314109-wb45naw2	165	67	-	-	JJ
cord-314109-wb45naw2	165	68	coding	code	VBG
cord-314109-wb45naw2	165	69	ribonucleic	ribonucleic	JJ
cord-314109-wb45naw2	165	70	acids	acid	NNS
cord-314109-wb45naw2	165	71	,	,	,
cord-314109-wb45naw2	165	72	and	and	CC
cord-314109-wb45naw2	165	73	Rho	Rho	NNP
cord-314109-wb45naw2	165	74	/	/	SYM
cord-314109-wb45naw2	165	75	Rock	Rock	NNP
cord-314109-wb45naw2	165	76	Mammalian	Mammalian	NNP
cord-314109-wb45naw2	165	77	TOR	TOR	NNP
cord-314109-wb45naw2	165	78	complex	complex	NN
cord-314109-wb45naw2	166	1	2	2	CD
cord-314109-wb45naw2	166	2	controls	control	VBZ
cord-314109-wb45naw2	166	3	the	the	DT
cord-314109-wb45naw2	166	4	actin	actin	NN
cord-314109-wb45naw2	166	5	cytoskeleton	cytoskeleton	NN
cord-314109-wb45naw2	166	6	and	and	CC
cord-314109-wb45naw2	166	7	is	be	VBZ
cord-314109-wb45naw2	166	8	rapamycin	rapamycin	VBN
cord-314109-wb45naw2	166	9	insensitive	insensitive	JJ
cord-314109-wb45naw2	166	10	mTOR	mTOR	NNP
cord-314109-wb45naw2	166	11	complex	complex	JJ
cord-314109-wb45naw2	166	12	2	2	CD
cord-314109-wb45naw2	167	1	(	(	-LRB-
cord-314109-wb45naw2	167	2	mTORC2	mTORC2	JJS
cord-314109-wb45naw2	167	3	)	)	-RRB-
cord-314109-wb45naw2	167	4	controls	control	VBZ
cord-314109-wb45naw2	167	5	hydrophobic	hydrophobic	JJ
cord-314109-wb45naw2	167	6	motif	motif	NN
cord-314109-wb45naw2	167	7	phosphorylation	phosphorylation	NN
cord-314109-wb45naw2	167	8	and	and	CC
cord-314109-wb45naw2	167	9	activation	activation	NN
cord-314109-wb45naw2	167	10	of	of	IN
cord-314109-wb45naw2	167	11	serum	serum	NN
cord-314109-wb45naw2	167	12	-	-	HYPH
cord-314109-wb45naw2	167	13	and	and	CC
cord-314109-wb45naw2	167	14	glucocorticoid	glucocorticoid	NN
cord-314109-wb45naw2	167	15	-	-	HYPH
cord-314109-wb45naw2	167	16	induced	induce	VBN
cord-314109-wb45naw2	167	17	protein	protein	NN
cord-314109-wb45naw2	167	18	kinase	kinase	NN
cord-314109-wb45naw2	167	19	Protor-1	Protor-1	NNP
cord-314109-wb45naw2	167	20	is	be	VBZ
cord-314109-wb45naw2	167	21	required	require	VBN
cord-314109-wb45naw2	167	22	for	for	IN
cord-314109-wb45naw2	167	23	efficient	efficient	JJ
cord-314109-wb45naw2	167	24	mTORC2-mediated	mTORC2-mediated	NNP
cord-314109-wb45naw2	167	25	activation	activation	NN
cord-314109-wb45naw2	167	26	of	of	IN
cord-314109-wb45naw2	167	27	SGK1	SGK1	NNP
cord-314109-wb45naw2	167	28	in	in	IN
cord-314109-wb45naw2	167	29	the	the	DT
cord-314109-wb45naw2	167	30	kidney	kidney	NN
cord-314109-wb45naw2	167	31	mSin1	mSin1	NNP
cord-314109-wb45naw2	167	32	is	be	VBZ
cord-314109-wb45naw2	167	33	necessary	necessary	JJ
cord-314109-wb45naw2	167	34	for	for	IN
cord-314109-wb45naw2	167	35	Akt	Akt	NNP
cord-314109-wb45naw2	167	36	/	/	SYM
cord-314109-wb45naw2	167	37	PKB	PKB	NNP
cord-314109-wb45naw2	167	38	phosphorylation	phosphorylation	NN
cord-314109-wb45naw2	167	39	,	,	,
cord-314109-wb45naw2	167	40	and	and	CC
cord-314109-wb45naw2	167	41	its	-PRON-	PRP$
cord-314109-wb45naw2	167	42	isoforms	isoform	NNS
cord-314109-wb45naw2	167	43	define	define	VBP
cord-314109-wb45naw2	167	44	three	three	CD
cord-314109-wb45naw2	167	45	distinct	distinct	JJ
cord-314109-wb45naw2	167	46	mTORC2s	mTORC2s	NNP
cord-314109-wb45naw2	168	1	GPR120	GPR120	NNP
cord-314109-wb45naw2	168	2	facilitates	facilitate	VBZ
cord-314109-wb45naw2	168	3	cholesterol	cholesterol	NN
cord-314109-wb45naw2	168	4	efflux	efflux	NN
cord-314109-wb45naw2	168	5	in	in	IN
cord-314109-wb45naw2	168	6	macrophages	macrophage	NNS
cord-314109-wb45naw2	168	7	through	through	IN
cord-314109-wb45naw2	168	8	activation	activation	NN
cord-314109-wb45naw2	168	9	of	of	IN
cord-314109-wb45naw2	168	10	AMPK	AMPK	NNP
cord-314109-wb45naw2	168	11	signaling	signal	VBG
cord-314109-wb45naw2	168	12	pathway	pathway	NN
cord-314109-wb45naw2	168	13	Moving	move	VBG
cord-314109-wb45naw2	168	14	to	to	IN
cord-314109-wb45naw2	168	15	the	the	DT
cord-314109-wb45naw2	168	16	rhythm	rhythm	NN
cord-314109-wb45naw2	168	17	with	with	IN
cord-314109-wb45naw2	168	18	clock	clock	NN
cord-314109-wb45naw2	168	19	(	(	-LRB-
cord-314109-wb45naw2	168	20	circadian	circadian	NN
cord-314109-wb45naw2	168	21	)	)	-RRB-
cord-314109-wb45naw2	168	22	genes	gene	NNS
cord-314109-wb45naw2	168	23	,	,	,
cord-314109-wb45naw2	168	24	autophagy	autophagy	NN
cord-314109-wb45naw2	168	25	,	,	,
cord-314109-wb45naw2	168	26	mTOR	mTOR	NNP
cord-314109-wb45naw2	168	27	,	,	,
cord-314109-wb45naw2	168	28	and	and	CC
cord-314109-wb45naw2	168	29	SIRT1	sirt1	XX
cord-314109-wb45naw2	168	30	in	in	IN
cord-314109-wb45naw2	168	31	degenerative	degenerative	JJ
cord-314109-wb45naw2	168	32	disease	disease	NN
cord-314109-wb45naw2	168	33	and	and	CC
cord-314109-wb45naw2	168	34	cancer	cancer	NN
cord-314109-wb45naw2	168	35	Prospects	prospect	NNS
cord-314109-wb45naw2	168	36	and	and	CC
cord-314109-wb45naw2	168	37	perspectives	perspective	NNS
cord-314109-wb45naw2	168	38	for	for	IN
cord-314109-wb45naw2	168	39	WISP1	wisp1	ADD
cord-314109-wb45naw2	169	1	(	(	-LRB-
cord-314109-wb45naw2	169	2	CCN4	CCN4	NNP
cord-314109-wb45naw2	169	3	)	)	-RRB-
cord-314109-wb45naw2	169	4	in	in	IN
cord-314109-wb45naw2	169	5	Diabetes	diabetes	NN
cord-314109-wb45naw2	169	6	Mellitus	Mellitus	NNP
cord-314109-wb45naw2	169	7	Aldose	Aldose	NNP
cord-314109-wb45naw2	169	8	reductase	reductase	NN
cord-314109-wb45naw2	169	9	regulates	regulate	VBZ
cord-314109-wb45naw2	169	10	hyperglycemia	hyperglycemia	NN
cord-314109-wb45naw2	169	11	-	-	HYPH
cord-314109-wb45naw2	169	12	induced	induce	VBN
cord-314109-wb45naw2	169	13	HUVEC	HUVEC	NNP
cord-314109-wb45naw2	169	14	death	death	NN
cord-314109-wb45naw2	169	15	via	via	IN
cord-314109-wb45naw2	169	16	SIRT1	sirt1	NN
cord-314109-wb45naw2	169	17	/	/	SYM
cord-314109-wb45naw2	169	18	AMPK	AMPK	NNP
cord-314109-wb45naw2	169	19	-	-	HYPH
cord-314109-wb45naw2	169	20	alpha1/	alpha1/	NNP
cord-314109-wb45naw2	170	1	mTOR	mTOR	NNP
cord-314109-wb45naw2	170	2	pathway	pathway	NN
cord-314109-wb45naw2	170	3	Hesperetin	Hesperetin	NNP
cord-314109-wb45naw2	170	4	is	be	VBZ
cord-314109-wb45naw2	170	5	a	a	DT
cord-314109-wb45naw2	170	6	potent	potent	JJ
cord-314109-wb45naw2	170	7	bioactivator	bioactivator	NN
cord-314109-wb45naw2	170	8	that	that	WDT
cord-314109-wb45naw2	170	9	activates	activate	VBZ
cord-314109-wb45naw2	170	10	SIRT1-AMPK	SIRT1-AMPK	NNP
cord-314109-wb45naw2	170	11	signaling	signal	VBG
cord-314109-wb45naw2	170	12	pathway	pathway	NN
cord-314109-wb45naw2	170	13	in	in	IN
cord-314109-wb45naw2	170	14	HepG2	HepG2	NNP
cord-314109-wb45naw2	170	15	cells	cell	NNS
cord-314109-wb45naw2	171	1	Salidroside	Salidroside	NNP
cord-314109-wb45naw2	171	2	attenuates	attenuate	VBZ
cord-314109-wb45naw2	171	3	oxidized	oxidize	VBN
cord-314109-wb45naw2	171	4	lowdensity	lowdensity	NN
cord-314109-wb45naw2	171	5	lipoproteininduced	lipoproteininduce	VBN
cord-314109-wb45naw2	171	6	endothelial	endothelial	JJ
cord-314109-wb45naw2	171	7	cell	cell	NN
cord-314109-wb45naw2	171	8	injury	injury	NN
cord-314109-wb45naw2	171	9	via	via	IN
cord-314109-wb45naw2	171	10	promotion	promotion	NN
cord-314109-wb45naw2	171	11	of	of	IN
cord-314109-wb45naw2	171	12	the	the	DT
cord-314109-wb45naw2	171	13	AMPK	AMPK	NNP
cord-314109-wb45naw2	171	14	/	/	SYM
cord-314109-wb45naw2	171	15	SIRT1	sirt1	NN
cord-314109-wb45naw2	171	16	pathway	pathway	NN
cord-314109-wb45naw2	171	17	Mitochondrial	mitochondrial	NN
cord-314109-wb45naw2	171	18	and	and	CC
cord-314109-wb45naw2	171	19	nuclear	nuclear	JJ
cord-314109-wb45naw2	171	20	DNA	dna	NN
cord-314109-wb45naw2	171	21	oxidative	oxidative	JJ
cord-314109-wb45naw2	171	22	damage	damage	NN
cord-314109-wb45naw2	171	23	in	in	IN
cord-314109-wb45naw2	171	24	physiological	physiological	JJ
cord-314109-wb45naw2	171	25	and	and	CC
cord-314109-wb45naw2	171	26	pathological	pathological	JJ
cord-314109-wb45naw2	171	27	aging	aging	NN
cord-314109-wb45naw2	171	28	Targeting	target	VBG
cord-314109-wb45naw2	171	29	oxidative	oxidative	JJ
cord-314109-wb45naw2	171	30	stress	stress	NN
cord-314109-wb45naw2	171	31	and	and	CC
cord-314109-wb45naw2	171	32	inflammation	inflammation	NN
cord-314109-wb45naw2	171	33	to	to	TO
cord-314109-wb45naw2	171	34	prevent	prevent	VB
cord-314109-wb45naw2	171	35	ischemia	ischemia	NN
cord-314109-wb45naw2	171	36	-	-	HYPH
cord-314109-wb45naw2	171	37	reperfusion	reperfusion	NN
cord-314109-wb45naw2	171	38	injury	injury	NN
cord-314109-wb45naw2	171	39	Exploration	Exploration	NNP
cord-314109-wb45naw2	171	40	of	of	IN
cord-314109-wb45naw2	171	41	age	age	NN
cord-314109-wb45naw2	171	42	-	-	HYPH
cord-314109-wb45naw2	171	43	related	relate	VBN
cord-314109-wb45naw2	171	44	mitochondrial	mitochondrial	JJ
cord-314109-wb45naw2	171	45	dysfunction	dysfunction	NN
cord-314109-wb45naw2	171	46	and	and	CC
cord-314109-wb45naw2	171	47	the	the	DT
cord-314109-wb45naw2	171	48	anti	anti	JJ
cord-314109-wb45naw2	171	49	-	-	JJ
cord-314109-wb45naw2	171	50	aging	aging	JJ
cord-314109-wb45naw2	171	51	effects	effect	NNS
cord-314109-wb45naw2	171	52	of	of	IN
cord-314109-wb45naw2	171	53	resveratrol	resveratrol	NN
cord-314109-wb45naw2	171	54	in	in	IN
cord-314109-wb45naw2	171	55	zebrafish	zebrafish	NN
cord-314109-wb45naw2	171	56	retina	retina	NN
cord-314109-wb45naw2	171	57	Glutamine	glutamine	NN
cord-314109-wb45naw2	171	58	protects	protect	VBZ
cord-314109-wb45naw2	171	59	against	against	IN
cord-314109-wb45naw2	171	60	oxidative	oxidative	JJ
cord-314109-wb45naw2	171	61	stress	stress	NN
cord-314109-wb45naw2	171	62	injury	injury	NN
cord-314109-wb45naw2	171	63	through	through	IN
cord-314109-wb45naw2	171	64	inhibiting	inhibit	VBG
cord-314109-wb45naw2	171	65	the	the	DT
cord-314109-wb45naw2	171	66	activation	activation	NN
cord-314109-wb45naw2	171	67	of	of	IN
cord-314109-wb45naw2	171	68	PI3K	PI3K	NNP
cord-314109-wb45naw2	171	69	/	/	SYM
cord-314109-wb45naw2	171	70	Akt	Akt	NNP
cord-314109-wb45naw2	171	71	signaling	signal	VBG
cord-314109-wb45naw2	171	72	pathway	pathway	NN
cord-314109-wb45naw2	171	73	in	in	IN
cord-314109-wb45naw2	172	1	parkinsonian	parkinsonian	NNP
cord-314109-wb45naw2	172	2	cell	cell	NN
cord-314109-wb45naw2	172	3	model	model	NN
cord-314109-wb45naw2	172	4	Donepezil	Donepezil	NNP
cord-314109-wb45naw2	172	5	improves	improve	VBZ
cord-314109-wb45naw2	172	6	neuropathy	neuropathy	NN
cord-314109-wb45naw2	172	7	through	through	IN
cord-314109-wb45naw2	172	8	activation	activation	NN
cord-314109-wb45naw2	172	9	of	of	IN
cord-314109-wb45naw2	172	10	AMPK	AMPK	NNP
cord-314109-wb45naw2	172	11	signalling	signal	VBG
cord-314109-wb45naw2	172	12	pathway	pathway	NN
cord-314109-wb45naw2	172	13	in	in	IN
cord-314109-wb45naw2	172	14	streptozotocin	streptozotocin	NN
cord-314109-wb45naw2	172	15	-	-	HYPH
cord-314109-wb45naw2	172	16	induced	induce	VBN
cord-314109-wb45naw2	172	17	diabetic	diabetic	JJ
cord-314109-wb45naw2	172	18	mice	mouse	NNS
cord-314109-wb45naw2	172	19	New	New	NNP
cord-314109-wb45naw2	172	20	Insights	Insights	NNPS
cord-314109-wb45naw2	172	21	for	for	IN
cord-314109-wb45naw2	172	22	oxidative	oxidative	JJ
cord-314109-wb45naw2	172	23	stress	stress	NN
cord-314109-wb45naw2	172	24	and	and	CC
cord-314109-wb45naw2	172	25	Diabetes	diabetes	NN
cord-314109-wb45naw2	172	26	Mellitus	Mellitus	NNP
cord-314109-wb45naw2	172	27	Harnessing	harness	VBG
cord-314109-wb45naw2	172	28	the	the	DT
cord-314109-wb45naw2	172	29	power	power	NN
cord-314109-wb45naw2	172	30	of	of	IN
cord-314109-wb45naw2	172	31	SIRT1	sirt1	NN
cord-314109-wb45naw2	172	32	and	and	CC
cord-314109-wb45naw2	172	33	non	non	JJ
cord-314109-wb45naw2	172	34	-	-	JJ
cord-314109-wb45naw2	172	35	coding	coding	JJ
cord-314109-wb45naw2	172	36	RNAs	rna	NNS
cord-314109-wb45naw2	172	37	in	in	IN
cord-314109-wb45naw2	172	38	vascular	vascular	JJ
cord-314109-wb45naw2	172	39	disease	disease	NN
cord-314109-wb45naw2	172	40	AMPK	AMPK	NNP
cord-314109-wb45naw2	172	41	activation	activation	NN
cord-314109-wb45naw2	172	42	:	:	:
cord-314109-wb45naw2	172	43	Role	role	NN
cord-314109-wb45naw2	172	44	in	in	IN
cord-314109-wb45naw2	172	45	the	the	DT
cord-314109-wb45naw2	172	46	signaling	signal	VBG
cord-314109-wb45naw2	172	47	pathways	pathway	NNS
cord-314109-wb45naw2	172	48	of	of	IN
cord-314109-wb45naw2	172	49	neuroinflammation	neuroinflammation	NN
cord-314109-wb45naw2	172	50	and	and	CC
cord-314109-wb45naw2	172	51	neurodegeneration	neurodegeneration	NN
cord-314109-wb45naw2	172	52	Specific	specific	JJ
cord-314109-wb45naw2	172	53	activation	activation	NN
cord-314109-wb45naw2	172	54	of	of	IN
cord-314109-wb45naw2	172	55	mTORC1	mTORC1	NNP
cord-314109-wb45naw2	172	56	by	by	IN
cord-314109-wb45naw2	172	57	Rheb	Rheb	NNP
cord-314109-wb45naw2	172	58	G	G	NNP
cord-314109-wb45naw2	172	59	-	-	HYPH
cord-314109-wb45naw2	172	60	protein	protein	NN
cord-314109-wb45naw2	172	61	in	in	IN
cord-314109-wb45naw2	172	62	vitro	vitro	FW
cord-314109-wb45naw2	172	63	involves	involve	VBZ
cord-314109-wb45naw2	172	64	enhanced	enhance	VBN
cord-314109-wb45naw2	172	65	recruitment	recruitment	NN
cord-314109-wb45naw2	172	66	of	of	IN
cord-314109-wb45naw2	172	67	its	-PRON-	PRP$
cord-314109-wb45naw2	172	68	substrate	substrate	NN
cord-314109-wb45naw2	172	69	protein	protein	NN
cord-314109-wb45naw2	172	70	TSC2	TSC2	NNP
cord-314109-wb45naw2	172	71	mediates	mediate	VBZ
cord-314109-wb45naw2	172	72	cellular	cellular	JJ
cord-314109-wb45naw2	172	73	energy	energy	NN
cord-314109-wb45naw2	172	74	response	response	NN
cord-314109-wb45naw2	172	75	to	to	TO
cord-314109-wb45naw2	172	76	control	control	VB
cord-314109-wb45naw2	172	77	cell	cell	NN
cord-314109-wb45naw2	172	78	growth	growth	NN
cord-314109-wb45naw2	172	79	and	and	CC
cord-314109-wb45naw2	172	80	survival	survival	NN
cord-314109-wb45naw2	172	81	Clinical	clinical	JJ
cord-314109-wb45naw2	172	82	insights	insight	NNS
cord-314109-wb45naw2	172	83	for	for	IN
cord-314109-wb45naw2	172	84	a	a	DT
cord-314109-wb45naw2	172	85	proliferative	proliferative	JJ
cord-314109-wb45naw2	172	86	and	and	CC
cord-314109-wb45naw2	172	87	restorative	restorative	JJ
cord-314109-wb45naw2	172	88	member	member	NN
cord-314109-wb45naw2	172	89	of	of	IN
cord-314109-wb45naw2	172	90	the	the	DT
cord-314109-wb45naw2	172	91	CCN	CCN	NNP
cord-314109-wb45naw2	172	92	family	family	NN
cord-314109-wb45naw2	172	93	Role	role	NN
cord-314109-wb45naw2	172	94	of	of	IN
cord-314109-wb45naw2	172	95	Akt	Akt	NNP
cord-314109-wb45naw2	172	96	activation	activation	NN
cord-314109-wb45naw2	172	97	in	in	IN
cord-314109-wb45naw2	172	98	PARP	PARP	NNP
cord-314109-wb45naw2	172	99	inhibitor	inhibitor	NN
cord-314109-wb45naw2	172	100	resistance	resistance	NN
cord-314109-wb45naw2	172	101	in	in	IN
cord-314109-wb45naw2	172	102	cancer	cancer	NN
cord-314109-wb45naw2	172	103	Bioactive	Bioactive	NNP
cord-314109-wb45naw2	172	104	components	component	NNS
cord-314109-wb45naw2	172	105	and	and	CC
cord-314109-wb45naw2	172	106	mechanisms	mechanism	NNS
cord-314109-wb45naw2	172	107	of	of	IN
cord-314109-wb45naw2	172	108	Chinese	chinese	JJ
cord-314109-wb45naw2	172	109	poplar	poplar	NN
cord-314109-wb45naw2	173	1	propolis	propolis	NN
cord-314109-wb45naw2	173	2	alleviates	alleviate	VBZ
cord-314109-wb45naw2	173	3	oxidized	oxidize	VBN
cord-314109-wb45naw2	173	4	low	low	JJ
cord-314109-wb45naw2	173	5	-	-	HYPH
cord-314109-wb45naw2	173	6	density	density	NN
cord-314109-wb45naw2	173	7	lipoprotein	lipoprotein	NN
cord-314109-wb45naw2	173	8	-	-	HYPH
cord-314109-wb45naw2	173	9	induced	induce	VBN
cord-314109-wb45naw2	173	10	endothelial	endothelial	JJ
cord-314109-wb45naw2	173	11	cells	cell	NNS
cord-314109-wb45naw2	173	12	injury	injury	NN
cord-314109-wb45naw2	174	1	R)-(+)-alpha	R)-(+)-alpha	NNP
cord-314109-wb45naw2	174	2	-	-	HYPH
cord-314109-wb45naw2	174	3	Lipoic	lipoic	NN
cord-314109-wb45naw2	174	4	acid	acid	NN
cord-314109-wb45naw2	174	5	protected	protect	VBN
cord-314109-wb45naw2	174	6	NG108	ng108	NN
cord-314109-wb45naw2	174	7	-	-	HYPH
cord-314109-wb45naw2	174	8	15	15	CD
cord-314109-wb45naw2	174	9	cells	cell	NNS
cord-314109-wb45naw2	174	10	against	against	IN
cord-314109-wb45naw2	174	11	H2O2-induced	h2o2-induced	JJ
cord-314109-wb45naw2	174	12	cell	cell	NN
cord-314109-wb45naw2	174	13	death	death	NN
cord-314109-wb45naw2	174	14	through	through	IN
cord-314109-wb45naw2	174	15	PI3	PI3	NNP
cord-314109-wb45naw2	174	16	K	K	NNP
cord-314109-wb45naw2	175	1	-Akt	-Akt	NFP
cord-314109-wb45naw2	175	2	/	/	SYM
cord-314109-wb45naw2	175	3	GSK-3beta	gsk-3beta	NN
cord-314109-wb45naw2	175	4	pathway	pathway	NN
cord-314109-wb45naw2	175	5	and	and	CC
cord-314109-wb45naw2	175	6	suppression	suppression	NN
cord-314109-wb45naw2	175	7	of	of	IN
cord-314109-wb45naw2	175	8	NF	nf	NN
cord-314109-wb45naw2	175	9	-	-	HYPH
cord-314109-wb45naw2	175	10	kappabetacytokines	kappabetacytokine	NNS
cord-314109-wb45naw2	175	11	Adenosine	Adenosine	NNP
cord-314109-wb45naw2	175	12	A1-receptors	A1-receptors	NNPS
cord-314109-wb45naw2	175	13	modulate	modulate	VBP
cord-314109-wb45naw2	175	14	mtor	mtor	NN
cord-314109-wb45naw2	175	15	signaling	signal	VBG
cord-314109-wb45naw2	175	16	to	to	TO
cord-314109-wb45naw2	175	17	regulate	regulate	VB
cord-314109-wb45naw2	175	18	white	white	JJ
cord-314109-wb45naw2	175	19	matter	matter	NN
cord-314109-wb45naw2	175	20	inflammatory	inflammatory	JJ
cord-314109-wb45naw2	175	21	lesions	lesion	NNS
cord-314109-wb45naw2	175	22	induced	induce	VBN
cord-314109-wb45naw2	175	23	by	by	IN
cord-314109-wb45naw2	175	24	chronic	chronic	JJ
cord-314109-wb45naw2	175	25	cerebral	cerebral	JJ
cord-314109-wb45naw2	175	26	hypoperfusion	hypoperfusion	NN
cord-314109-wb45naw2	175	27	Acute	Acute	NNP
cord-314109-wb45naw2	175	28	metformin	metformin	NNP
cord-314109-wb45naw2	175	29	preconditioning	preconditioning	NN
cord-314109-wb45naw2	175	30	confers	confer	VBZ
cord-314109-wb45naw2	175	31	neuroprotection	neuroprotection	NN
cord-314109-wb45naw2	175	32	against	against	IN
cord-314109-wb45naw2	175	33	focal	focal	JJ
cord-314109-wb45naw2	175	34	cerebral	cerebral	JJ
cord-314109-wb45naw2	175	35	ischaemia	ischaemia	NN
cord-314109-wb45naw2	175	36	by	by	IN
cord-314109-wb45naw2	175	37	preactivation	preactivation	NN
cord-314109-wb45naw2	175	38	of	of	IN
cord-314109-wb45naw2	175	39	AMPK	AMPK	NNP
cord-314109-wb45naw2	175	40	-	-	HYPH
cord-314109-wb45naw2	175	41	dependent	dependent	JJ
cord-314109-wb45naw2	175	42	autophagy	autophagy	NN
cord-314109-wb45naw2	175	43	Guidelines	guideline	NNS
cord-314109-wb45naw2	175	44	for	for	IN
cord-314109-wb45naw2	175	45	the	the	DT
cord-314109-wb45naw2	175	46	use	use	NN
cord-314109-wb45naw2	175	47	and	and	CC
cord-314109-wb45naw2	175	48	interpretation	interpretation	NN
cord-314109-wb45naw2	175	49	of	of	IN
cord-314109-wb45naw2	175	50	assays	assay	NNS
cord-314109-wb45naw2	175	51	for	for	IN
cord-314109-wb45naw2	175	52	monitoring	monitor	VBG
cord-314109-wb45naw2	175	53	autophagy	autophagy	NN
cord-314109-wb45naw2	175	54	Targeting	target	VBG
cord-314109-wb45naw2	175	55	disease	disease	NN
cord-314109-wb45naw2	175	56	through	through	IN
cord-314109-wb45naw2	175	57	novel	novel	JJ
cord-314109-wb45naw2	175	58	pathways	pathway	NNS
cord-314109-wb45naw2	175	59	of	of	IN
cord-314109-wb45naw2	175	60	apoptosis	apoptosis	NN
cord-314109-wb45naw2	175	61	and	and	CC
cord-314109-wb45naw2	175	62	autophagy	autophagy	VB
cord-314109-wb45naw2	175	63	Metformin	Metformin	NNP
cord-314109-wb45naw2	175	64	,	,	,
cord-314109-wb45naw2	175	65	independent	independent	JJ
cord-314109-wb45naw2	175	66	of	of	IN
cord-314109-wb45naw2	175	67	AMPK	AMPK	NNP
cord-314109-wb45naw2	175	68	,	,	,
cord-314109-wb45naw2	175	69	inhibits	inhibit	VBZ
cord-314109-wb45naw2	175	70	mTORC1	mtorc1	PRP
cord-314109-wb45naw2	175	71	in	in	IN
cord-314109-wb45naw2	175	72	a	a	DT
cord-314109-wb45naw2	175	73	rag	rag	NN
cord-314109-wb45naw2	175	74	GTPase	gtpase	NN
cord-314109-wb45naw2	175	75	-	-	HYPH
cord-314109-wb45naw2	175	76	dependent	dependent	JJ
cord-314109-wb45naw2	175	77	manner	manner	NN
cord-314109-wb45naw2	175	78	Dissociation	dissociation	NN
cord-314109-wb45naw2	175	79	of	of	IN
cord-314109-wb45naw2	175	80	Bcl-2-Beclin1	Bcl-2-Beclin1	NNP
cord-314109-wb45naw2	175	81	complex	complex	JJ
cord-314109-wb45naw2	175	82	by	by	IN
cord-314109-wb45naw2	175	83	activated	activate	VBN
cord-314109-wb45naw2	175	84	AMPK	AMPK	NNP
cord-314109-wb45naw2	175	85	enhances	enhance	VBZ
cord-314109-wb45naw2	175	86	cardiac	cardiac	JJ
cord-314109-wb45naw2	175	87	autophagy	autophagy	NN
cord-314109-wb45naw2	175	88	and	and	CC
cord-314109-wb45naw2	175	89	protects	protect	VBZ
cord-314109-wb45naw2	175	90	against	against	IN
cord-314109-wb45naw2	175	91	cardiomyocyte	cardiomyocyte	NNP
cord-314109-wb45naw2	175	92	apoptosis	apoptosis	NN
cord-314109-wb45naw2	175	93	in	in	IN
cord-314109-wb45naw2	175	94	diabetes	diabetes	NN
cord-314109-wb45naw2	175	95	Metformin	Metformin	NNP
cord-314109-wb45naw2	175	96	protects	protect	VBZ
cord-314109-wb45naw2	175	97	against	against	IN
cord-314109-wb45naw2	175	98	experimental	experimental	JJ
cord-314109-wb45naw2	175	99	acrylamide	acrylamide	NN
cord-314109-wb45naw2	175	100	neuropathy	neuropathy	NN
cord-314109-wb45naw2	175	101	in	in	IN
cord-314109-wb45naw2	175	102	rats	rat	NNS
cord-314109-wb45naw2	175	103	Randomized	randomize	VBD
cord-314109-wb45naw2	175	104	controlled	control	VBN
cord-314109-wb45naw2	175	105	trial	trial	NN
cord-314109-wb45naw2	175	106	comparing	compare	VBG
cord-314109-wb45naw2	175	107	hydroxychloroquine	hydroxychloroquine	NNP
cord-314109-wb45naw2	175	108	with	with	IN
cord-314109-wb45naw2	175	109	pioglitazone	pioglitazone	NN
cord-314109-wb45naw2	175	110	as	as	IN
cord-314109-wb45naw2	175	111	third	third	JJ
cord-314109-wb45naw2	175	112	-	-	HYPH
cord-314109-wb45naw2	175	113	line	line	NN
cord-314109-wb45naw2	175	114	agents	agent	NNS
cord-314109-wb45naw2	175	115	in	in	IN
cord-314109-wb45naw2	175	116	type	type	NN
cord-314109-wb45naw2	175	117	2	2	CD
cord-314109-wb45naw2	175	118	diabetic	diabetic	JJ
cord-314109-wb45naw2	175	119	patients	patient	NNS
cord-314109-wb45naw2	175	120	failing	fail	VBG
cord-314109-wb45naw2	175	121	metformin	metformin	NNP
cord-314109-wb45naw2	175	122	plus	plus	CC
cord-314109-wb45naw2	175	123	a	a	DT
cord-314109-wb45naw2	175	124	sulfonylurea	sulfonylurea	NN
cord-314109-wb45naw2	175	125	:	:	:
cord-314109-wb45naw2	175	126	A	a	DT
cord-314109-wb45naw2	175	127	pilot	pilot	NN
cord-314109-wb45naw2	175	128	study	study	NN
cord-314109-wb45naw2	175	129	4EBP	4ebp	RB
cord-314109-wb45naw2	175	130	-	-	HYPH
cord-314109-wb45naw2	175	131	dependent	dependent	JJ
cord-314109-wb45naw2	175	132	signaling	signaling	NN
cord-314109-wb45naw2	175	133	supports	support	VBZ
cord-314109-wb45naw2	175	134	west	west	NNP
cord-314109-wb45naw2	175	135	nile	nile	NNP
cord-314109-wb45naw2	175	136	virus	virus	NN
cord-314109-wb45naw2	175	137	growth	growth	NN
cord-314109-wb45naw2	175	138	and	and	CC
cord-314109-wb45naw2	175	139	protein	protein	NN
cord-314109-wb45naw2	175	140	expression	expression	NN
cord-314109-wb45naw2	176	1	Geranylgeranylacetone	Geranylgeranylacetone	NNP
cord-314109-wb45naw2	176	2	has	have	VBZ
cord-314109-wb45naw2	176	3	anti	anti	JJ
cord-314109-wb45naw2	176	4	-	-	JJ
cord-314109-wb45naw2	176	5	hepatitis	hepatitis	JJ
cord-314109-wb45naw2	176	6	C	c	NN
cord-314109-wb45naw2	176	7	virus	virus	NN
cord-314109-wb45naw2	176	8	activity	activity	NN
cord-314109-wb45naw2	176	9	via	via	IN
cord-314109-wb45naw2	176	10	activation	activation	NN
cord-314109-wb45naw2	176	11	of	of	IN
cord-314109-wb45naw2	176	12	mTOR	mTOR	NNP
cord-314109-wb45naw2	176	13	in	in	IN
cord-314109-wb45naw2	176	14	human	human	JJ
cord-314109-wb45naw2	176	15	hepatoma	hepatoma	NNP
cord-314109-wb45naw2	176	16	cells	cell	NNS
cord-314109-wb45naw2	177	1	The	the	DT
cord-314109-wb45naw2	177	2	critical	critical	JJ
cord-314109-wb45naw2	177	3	role	role	NN
cord-314109-wb45naw2	177	4	of	of	IN
cord-314109-wb45naw2	177	5	IL-15-PI3K	il-15-pi3k	JJ
cord-314109-wb45naw2	177	6	-	-	HYPH
cord-314109-wb45naw2	177	7	mTOR	mtor	JJ
cord-314109-wb45naw2	177	8	pathway	pathway	NN
cord-314109-wb45naw2	177	9	in	in	IN
cord-314109-wb45naw2	177	10	natural	natural	JJ
cord-314109-wb45naw2	177	11	killer	killer	NN
cord-314109-wb45naw2	177	12	cell	cell	NN
cord-314109-wb45naw2	177	13	effector	effector	NN
cord-314109-wb45naw2	177	14	functions	function	NNS
cord-314109-wb45naw2	177	15	Wogonin	Wogonin	NNP
cord-314109-wb45naw2	177	16	,	,	,
cord-314109-wb45naw2	177	17	a	a	DT
cord-314109-wb45naw2	177	18	flavonoid	flavonoid	NN
cord-314109-wb45naw2	177	19	isolated	isolate	VBN
cord-314109-wb45naw2	177	20	from	from	IN
cord-314109-wb45naw2	177	21	Scutellaria	Scutellaria	NNP
cord-314109-wb45naw2	177	22	baicalensis	baicalensis	NNP
cord-314109-wb45naw2	177	23	,	,	,
cord-314109-wb45naw2	177	24	has	have	VBZ
cord-314109-wb45naw2	177	25	anti	anti	JJ
cord-314109-wb45naw2	177	26	-	-	JJ
cord-314109-wb45naw2	177	27	viral	viral	JJ
cord-314109-wb45naw2	177	28	activities	activity	NNS
cord-314109-wb45naw2	177	29	against	against	IN
cord-314109-wb45naw2	177	30	influenza	influenza	NN
cord-314109-wb45naw2	177	31	infection	infection	NN
cord-314109-wb45naw2	177	32	via	via	IN
cord-314109-wb45naw2	177	33	modulation	modulation	NN
cord-314109-wb45naw2	177	34	of	of	IN
cord-314109-wb45naw2	177	35	AMPK	AMPK	NNP
cord-314109-wb45naw2	177	36	pathways	pathway	NNS
cord-314109-wb45naw2	177	37	Metformin	Metformin	NNP
cord-314109-wb45naw2	177	38	-	-	HYPH
cord-314109-wb45naw2	177	39	induced	induce	VBN
cord-314109-wb45naw2	177	40	suppression	suppression	NN
cord-314109-wb45naw2	177	41	of	of	IN
cord-314109-wb45naw2	177	42	IFN	IFN	NNP
cord-314109-wb45naw2	177	43	-	-	HYPH
cord-314109-wb45naw2	177	44	alpha	alpha	NN
cord-314109-wb45naw2	177	45	via	via	IN
cord-314109-wb45naw2	177	46	mTORC1	mTORC1	NNP
cord-314109-wb45naw2	177	47	signalling	signal	VBG
cord-314109-wb45naw2	177	48	following	follow	VBG
cord-314109-wb45naw2	177	49	seasonal	seasonal	JJ
cord-314109-wb45naw2	177	50	vaccination	vaccination	NN
cord-314109-wb45naw2	177	51	is	be	VBZ
cord-314109-wb45naw2	177	52	associated	associate	VBN
cord-314109-wb45naw2	177	53	with	with	IN
cord-314109-wb45naw2	177	54	impaired	impaired	JJ
cord-314109-wb45naw2	177	55	antibody	antibody	NN
cord-314109-wb45naw2	177	56	responses	response	NNS
cord-314109-wb45naw2	177	57	in	in	IN
cord-314109-wb45naw2	177	58	type	type	NN
cord-314109-wb45naw2	177	59	2	2	CD
cord-314109-wb45naw2	177	60	diabetes	diabetes	NN
cord-314109-wb45naw2	177	61	mTORC1	mtorc1	CD
cord-314109-wb45naw2	177	62	restricts	restrict	VBZ
cord-314109-wb45naw2	177	63	hepatitis	hepatitis	NN
cord-314109-wb45naw2	177	64	C	C	NNP
cord-314109-wb45naw2	177	65	virus	virus	NN
cord-314109-wb45naw2	177	66	RNA	RNA	NNP
cord-314109-wb45naw2	177	67	replication	replication	NN
cord-314109-wb45naw2	177	68	through	through	IN
cord-314109-wb45naw2	177	69	ULK1-mediated	ULK1-mediated	NNP
cord-314109-wb45naw2	177	70	suppression	suppression	NN
cord-314109-wb45naw2	177	71	of	of	IN
cord-314109-wb45naw2	177	72	miR-122	miR-122	NNP
cord-314109-wb45naw2	177	73	and	and	CC
cord-314109-wb45naw2	177	74	facilitates	facilitate	VBZ
cord-314109-wb45naw2	177	75	postreplication	postreplication	NN
cord-314109-wb45naw2	177	76	events	event	NNS
cord-314109-wb45naw2	177	77	Declared	declare	VBD
cord-314109-wb45naw2	177	78	none	none	NN
cord-314109-wb45naw2	177	79	.	.	.