id	sid	tid	token	lemma	pos
cord-314013-g091lv0s	1	1	key	key	JJ
cord-314013-g091lv0s	1	2	:	:	:
cord-314013-g091lv0s	1	3	cord-314013-g091lv0s	cord-314013-g091lv0	NNS
cord-314013-g091lv0s	2	1	authors	author	NNS
cord-314013-g091lv0s	2	2	:	:	:
cord-314013-g091lv0s	2	3	Belladonna	Belladonna	NNP
cord-314013-g091lv0s	2	4	,	,	,
cord-314013-g091lv0s	2	5	Maria	Maria	NNP
cord-314013-g091lv0s	2	6	Laura	Laura	NNP
cord-314013-g091lv0s	2	7	;	;	:
cord-314013-g091lv0s	2	8	Orabona	Orabona	NNP
cord-314013-g091lv0s	2	9	,	,	,
cord-314013-g091lv0s	3	1	Ciriana	Ciriana	NNP
cord-314013-g091lv0s	3	2	title	title	NN
cord-314013-g091lv0s	3	3	:	:	:
cord-314013-g091lv0s	3	4	Potential	potential	JJ
cord-314013-g091lv0s	3	5	Benefits	benefit	NNS
cord-314013-g091lv0s	3	6	of	of	IN
cord-314013-g091lv0s	3	7	Tryptophan	Tryptophan	NNP
cord-314013-g091lv0s	3	8	Metabolism	metabolism	NN
cord-314013-g091lv0s	3	9	to	to	IN
cord-314013-g091lv0s	3	10	the	the	DT
cord-314013-g091lv0s	3	11	Efficacy	Efficacy	NNP
cord-314013-g091lv0s	3	12	of	of	IN
cord-314013-g091lv0s	3	13	Tocilizumab	Tocilizumab	NNP
cord-314013-g091lv0s	3	14	in	in	IN
cord-314013-g091lv0s	3	15	COVID-19	covid-19	CD
cord-314013-g091lv0s	3	16	date	date	NN
cord-314013-g091lv0s	3	17	:	:	:
cord-314013-g091lv0s	3	18	2020	2020	CD
cord-314013-g091lv0s	3	19	-	-	HYPH
cord-314013-g091lv0s	3	20	06	06	CD
cord-314013-g091lv0s	3	21	-	-	SYM
cord-314013-g091lv0s	3	22	19	19	CD
cord-314013-g091lv0s	3	23	journal	journal	NN
cord-314013-g091lv0s	3	24	:	:	:
cord-314013-g091lv0s	4	1	Front	front	JJ
cord-314013-g091lv0s	4	2	Pharmacol	Pharmacol	NNP
cord-314013-g091lv0s	4	3	DOI	DOI	NNP
cord-314013-g091lv0s	4	4	:	:	:
cord-314013-g091lv0s	4	5	10.3389	10.3389	CD
cord-314013-g091lv0s	4	6	/	/	SYM
cord-314013-g091lv0s	4	7	fphar.2020.00959	fphar.2020.00959	NN
cord-314013-g091lv0s	4	8	sha	sha	NNP
cord-314013-g091lv0s	4	9	:	:	:
cord-314013-g091lv0s	4	10	f7d5946bf5942311d766b2dc0bd058e593a1be36	f7d5946bf5942311d766b2dc0bd058e593a1be36	NNP
cord-314013-g091lv0s	4	11	doc_id	doc_id	CD
cord-314013-g091lv0s	4	12	:	:	:
cord-314013-g091lv0s	4	13	314013	314013	CD
cord-314013-g091lv0s	4	14	cord_uid	cord_uid	NN
cord-314013-g091lv0s	4	15	:	:	:
cord-314013-g091lv0s	5	1	g091lv0s	g091lv0s	.
cord-314013-g091lv0s	6	1	Tocilizumab	Tocilizumab	NNP
cord-314013-g091lv0s	6	2	has	have	VBZ
cord-314013-g091lv0s	6	3	been	be	VBN
cord-314013-g091lv0s	6	4	proposed	propose	VBN
cord-314013-g091lv0s	6	5	as	as	IN
cord-314013-g091lv0s	6	6	a	a	DT
cord-314013-g091lv0s	6	7	means	means	NN
cord-314013-g091lv0s	6	8	of	of	IN
cord-314013-g091lv0s	6	9	opposing	oppose	VBG
cord-314013-g091lv0s	6	10	hyperinflammatory	hyperinflammatory	JJ
cord-314013-g091lv0s	6	11	responses	response	NNS
cord-314013-g091lv0s	6	12	in	in	IN
cord-314013-g091lv0s	6	13	intensive	intensive	JJ
cord-314013-g091lv0s	6	14	care	care	NN
cord-314013-g091lv0s	6	15	patients	patient	NNS
cord-314013-g091lv0s	6	16	with	with	IN
cord-314013-g091lv0s	6	17	COVID-19	COVID-19	NNP
cord-314013-g091lv0s	6	18	.	.	.
cord-314013-g091lv0s	7	1	Here	here	RB
cord-314013-g091lv0s	7	2	,	,	,
cord-314013-g091lv0s	7	3	we	-PRON-	PRP
cord-314013-g091lv0s	7	4	briefly	briefly	RB
cord-314013-g091lv0s	7	5	discuss	discuss	VBP
cord-314013-g091lv0s	7	6	the	the	DT
cord-314013-g091lv0s	7	7	potentially	potentially	RB
cord-314013-g091lv0s	7	8	multiple	multiple	JJ
cord-314013-g091lv0s	7	9	,	,	,
cord-314013-g091lv0s	7	10	synergistic	synergistic	JJ
cord-314013-g091lv0s	7	11	mechanisms	mechanism	NNS
cord-314013-g091lv0s	7	12	whereby	whereby	WRB
cord-314013-g091lv0s	7	13	tocilizumab	tocilizumab	NNP
cord-314013-g091lv0s	7	14	might	may	MD
cord-314013-g091lv0s	7	15	exert	exert	VB
cord-314013-g091lv0s	7	16	therapeutic	therapeutic	JJ
cord-314013-g091lv0s	7	17	activity	activity	NN
cord-314013-g091lv0s	7	18	,	,	,
cord-314013-g091lv0s	7	19	mostly	mostly	RB
cord-314013-g091lv0s	7	20	focusing	focus	VBG
cord-314013-g091lv0s	7	21	on	on	IN
cord-314013-g091lv0s	7	22	the	the	DT
cord-314013-g091lv0s	7	23	production	production	NN
cord-314013-g091lv0s	7	24	of	of	IN
cord-314013-g091lv0s	7	25	tryptophan	tryptophan	NN
cord-314013-g091lv0s	7	26	-	-	HYPH
cord-314013-g091lv0s	7	27	derived	derive	VBN
cord-314013-g091lv0s	7	28	catabolites	catabolite	NNS
cord-314013-g091lv0s	7	29	that	that	WDT
cord-314013-g091lv0s	7	30	would	would	MD
cord-314013-g091lv0s	7	31	result	result	VB
cord-314013-g091lv0s	7	32	from	from	IN
cord-314013-g091lv0s	7	33	blockade	blockade	NN
cord-314013-g091lv0s	7	34	of	of	IN
cord-314013-g091lv0s	7	35	IL-6	IL-6	NNP
cord-314013-g091lv0s	7	36	signaling	signal	VBG
cord-314013-g091lv0s	7	37	,	,	,
cord-314013-g091lv0s	7	38	as	as	IN
cord-314013-g091lv0s	7	39	contextualized	contextualize	VBN
cord-314013-g091lv0s	7	40	to	to	IN
cord-314013-g091lv0s	7	41	the	the	DT
cord-314013-g091lv0s	7	42	cytokine	cytokine	NN
cord-314013-g091lv0s	7	43	storm	storm	NN
cord-314013-g091lv0s	7	44	occurring	occur	VBG
cord-314013-g091lv0s	7	45	in	in	IN
cord-314013-g091lv0s	7	46	COVID-19	COVID-19	NNP
cord-314013-g091lv0s	7	47	patients	patient	NNS
cord-314013-g091lv0s	7	48	.	.	.
cord-314013-g091lv0s	8	1	On	on	IN
cord-314013-g091lv0s	8	2	March	March	NNP
cord-314013-g091lv0s	8	3	2020	2020	CD
cord-314013-g091lv0s	8	4	,	,	,
cord-314013-g091lv0s	8	5	the	the	DT
cord-314013-g091lv0s	8	6	viral	viral	JJ
cord-314013-g091lv0s	8	7	disease	disease	NN
cord-314013-g091lv0s	8	8	COVID-19	COVID-19	NNP
cord-314013-g091lv0s	8	9	sparked	spark	VBN
cord-314013-g091lv0s	8	10	by	by	IN
cord-314013-g091lv0s	8	11	severe	severe	JJ
cord-314013-g091lv0s	8	12	acute	acute	JJ
cord-314013-g091lv0s	8	13	respiratory	respiratory	JJ
cord-314013-g091lv0s	8	14	syndromecoronavirus	syndromecoronavirus	NNP
cord-314013-g091lv0s	8	15	2	2	CD
cord-314013-g091lv0s	9	1	(	(	-LRB-
cord-314013-g091lv0s	9	2	SARS	SARS	NNP
cord-314013-g091lv0s	9	3	-	-	HYPH
cord-314013-g091lv0s	9	4	CoV-2	CoV-2	NNP
cord-314013-g091lv0s	9	5	)	)	-RRB-
cord-314013-g091lv0s	9	6	began	begin	VBD
cord-314013-g091lv0s	9	7	to	to	TO
cord-314013-g091lv0s	9	8	spread	spread	VB
cord-314013-g091lv0s	9	9	to	to	IN
cord-314013-g091lv0s	9	10	such	such	PDT
cord-314013-g091lv0s	9	11	an	an	DT
cord-314013-g091lv0s	9	12	extent	extent	NN
cord-314013-g091lv0s	9	13	that	that	IN
cord-314013-g091lv0s	9	14	the	the	DT
cord-314013-g091lv0s	9	15	World	World	NNP
cord-314013-g091lv0s	9	16	Health	Health	NNP
cord-314013-g091lv0s	9	17	Organization	Organization	NNP
cord-314013-g091lv0s	9	18	formally	formally	RB
cord-314013-g091lv0s	9	19	recognized	recognize	VBD
cord-314013-g091lv0s	9	20	the	the	DT
cord-314013-g091lv0s	9	21	COVID-19	covid-19	JJ
cord-314013-g091lv0s	9	22	outbreak	outbreak	NN
cord-314013-g091lv0s	9	23	as	as	IN
cord-314013-g091lv0s	9	24	a	a	DT
cord-314013-g091lv0s	9	25	pandemic	pandemic	NN
cord-314013-g091lv0s	9	26	.	.	.
cord-314013-g091lv0s	10	1	SARS	SARS	NNP
cord-314013-g091lv0s	10	2	-	-	HYPH
cord-314013-g091lv0s	10	3	CoV-2	CoV-2	NNP
cord-314013-g091lv0s	10	4	is	be	VBZ
cord-314013-g091lv0s	10	5	responsible	responsible	JJ
cord-314013-g091lv0s	10	6	for	for	IN
cord-314013-g091lv0s	10	7	SARS	SARS	NNP
cord-314013-g091lv0s	10	8	that	that	WDT
cord-314013-g091lv0s	10	9	is	be	VBZ
cord-314013-g091lv0s	10	10	less	less	RBR
cord-314013-g091lv0s	10	11	virulent	virulent	JJ
cord-314013-g091lv0s	10	12	,	,	,
cord-314013-g091lv0s	10	13	but	but	CC
cord-314013-g091lv0s	10	14	far	far	RB
cord-314013-g091lv0s	10	15	more	more	RBR
cord-314013-g091lv0s	10	16	contagious	contagious	JJ
cord-314013-g091lv0s	10	17	than	than	IN
cord-314013-g091lv0s	10	18	those	those	DT
cord-314013-g091lv0s	10	19	caused	cause	VBN
cord-314013-g091lv0s	10	20	by	by	IN
cord-314013-g091lv0s	10	21	SARS	SARS	NNP
cord-314013-g091lv0s	10	22	-	-	HYPH
cord-314013-g091lv0s	10	23	CoV	CoV	NNP
cord-314013-g091lv0s	10	24	and	and	CC
cord-314013-g091lv0s	10	25	middle	middle	NNP
cord-314013-g091lv0s	10	26	east	east	NNP
cord-314013-g091lv0s	10	27	respiratory	respiratory	JJ
cord-314013-g091lv0s	10	28	syndrome	syndrome	NN
cord-314013-g091lv0s	11	1	(	(	-LRB-
cord-314013-g091lv0s	11	2	MERS)-CoV	MERS)-CoV	NNP
cord-314013-g091lv0s	12	1	(	(	-LRB-
cord-314013-g091lv0s	12	2	Prompetchara	Prompetchara	NNP
cord-314013-g091lv0s	12	3	et	et	NNP
cord-314013-g091lv0s	12	4	al	al	NNP
cord-314013-g091lv0s	12	5	.	.	NNP
cord-314013-g091lv0s	12	6	,	,	,
cord-314013-g091lv0s	12	7	2020	2020	CD
cord-314013-g091lv0s	12	8	)	)	-RRB-
cord-314013-g091lv0s	12	9	,	,	,
cord-314013-g091lv0s	12	10	two	two	CD
cord-314013-g091lv0s	12	11	viruses	virus	NNS
cord-314013-g091lv0s	12	12	also	also	RB
cord-314013-g091lv0s	12	13	belonging	belong	VBG
cord-314013-g091lv0s	12	14	in	in	IN
cord-314013-g091lv0s	12	15	the	the	DT
cord-314013-g091lv0s	12	16	Betacoronavirus	Betacoronavirus	NNP
cord-314013-g091lv0s	12	17	genus	genus	NN
cord-314013-g091lv0s	12	18	.	.	.
cord-314013-g091lv0s	13	1	Several	several	JJ
cord-314013-g091lv0s	13	2	studies	study	NNS
cord-314013-g091lv0s	13	3	suggested	suggest	VBD
cord-314013-g091lv0s	13	4	that	that	IN
cord-314013-g091lv0s	13	5	the	the	DT
cord-314013-g091lv0s	13	6	main	main	JJ
cord-314013-g091lv0s	13	7	source	source	NN
cord-314013-g091lv0s	13	8	of	of	IN
cord-314013-g091lv0s	13	9	SARS	SARS	NNP
cord-314013-g091lv0s	13	10	-	-	HYPH
cord-314013-g091lv0s	13	11	CoV-2	CoV-2	NNP
cord-314013-g091lv0s	13	12	transmission	transmission	NN
cord-314013-g091lv0s	13	13	to	to	IN
cord-314013-g091lv0s	13	14	humans	human	NNS
cord-314013-g091lv0s	13	15	is	be	VBZ
cord-314013-g091lv0s	13	16	represented	represent	VBN
cord-314013-g091lv0s	13	17	by	by	IN
cord-314013-g091lv0s	13	18	bats	bat	NNS
cord-314013-g091lv0s	13	19	,	,	,
cord-314013-g091lv0s	13	20	natural	natural	JJ
cord-314013-g091lv0s	13	21	hosts	host	NNS
cord-314013-g091lv0s	13	22	of	of	IN
cord-314013-g091lv0s	13	23	a	a	DT
cord-314013-g091lv0s	13	24	wide	wide	JJ
cord-314013-g091lv0s	13	25	variety	variety	NN
cord-314013-g091lv0s	13	26	of	of	IN
cord-314013-g091lv0s	13	27	CoVs	CoVs	NNP
cord-314013-g091lv0s	13	28	.	.	.
cord-314013-g091lv0s	14	1	Such	such	JJ
cord-314013-g091lv0s	14	2	a	a	DT
cord-314013-g091lv0s	14	3	transmission	transmission	NN
cord-314013-g091lv0s	14	4	likely	likely	RB
cord-314013-g091lv0s	14	5	involved	involve	VBD
cord-314013-g091lv0s	14	6	multiple	multiple	JJ
cord-314013-g091lv0s	14	7	intermediate	intermediate	JJ
cord-314013-g091lv0s	14	8	hosts	host	NNS
cord-314013-g091lv0s	14	9	-	-	:
cord-314013-g091lv0s	14	10	including	include	VBG
cord-314013-g091lv0s	14	11	turtles	turtle	NNS
cord-314013-g091lv0s	14	12	,	,	,
cord-314013-g091lv0s	14	13	pangolin	pangolin	NN
cord-314013-g091lv0s	14	14	,	,	,
cord-314013-g091lv0s	14	15	and	and	CC
cord-314013-g091lv0s	14	16	snakes	snake	NNS
cord-314013-g091lv0s	14	17	-	-	:
cord-314013-g091lv0s	14	18	whereby	whereby	WRB
cord-314013-g091lv0s	14	19	the	the	DT
cord-314013-g091lv0s	14	20	viral	viral	JJ
cord-314013-g091lv0s	14	21	genome	genome	NN
cord-314013-g091lv0s	14	22	accumulated	accumulate	VBD
cord-314013-g091lv0s	14	23	a	a	DT
cord-314013-g091lv0s	14	24	series	series	NN
cord-314013-g091lv0s	14	25	of	of	IN
cord-314013-g091lv0s	14	26	mutations	mutation	NNS
cord-314013-g091lv0s	14	27	,	,	,
cord-314013-g091lv0s	14	28	ultimately	ultimately	RB
cord-314013-g091lv0s	14	29	permissive	permissive	JJ
cord-314013-g091lv0s	14	30	of	of	IN
cord-314013-g091lv0s	14	31	the	the	DT
cord-314013-g091lv0s	14	32	jump	jump	NN
cord-314013-g091lv0s	14	33	the	the	DT
cord-314013-g091lv0s	14	34	human	human	JJ
cord-314013-g091lv0s	14	35	species	specie	NNS
cord-314013-g091lv0s	15	1	(	(	-LRB-
cord-314013-g091lv0s	15	2	Giovanetti	Giovanetti	NNP
cord-314013-g091lv0s	15	3	and	and	CC
cord-314013-g091lv0s	15	4	Benvenuto	Benvenuto	NNP
cord-314013-g091lv0s	15	5	,	,	,
cord-314013-g091lv0s	15	6	2020	2020	CD
cord-314013-g091lv0s	15	7	)	)	-RRB-
cord-314013-g091lv0s	15	8	.	.	.
cord-314013-g091lv0s	16	1	Spread	Spread	VBN
cord-314013-g091lv0s	16	2	through	through	IN
cord-314013-g091lv0s	16	3	the	the	DT
cord-314013-g091lv0s	16	4	respiratory	respiratory	JJ
cord-314013-g091lv0s	16	5	tract	tract	NN
cord-314013-g091lv0s	16	6	by	by	IN
cord-314013-g091lv0s	16	7	the	the	DT
cord-314013-g091lv0s	16	8	spraying	spraying	NN
cord-314013-g091lv0s	16	9	of	of	IN
cord-314013-g091lv0s	16	10	droplets	droplet	NNS
cord-314013-g091lv0s	16	11	and	and	CC
cord-314013-g091lv0s	16	12	via	via	IN
cord-314013-g091lv0s	16	13	close	close	JJ
cord-314013-g091lv0s	16	14	contact	contact	NN
cord-314013-g091lv0s	16	15	,	,	,
cord-314013-g091lv0s	16	16	human	human	NN
cord-314013-g091lv0s	16	17	-	-	HYPH
cord-314013-g091lv0s	16	18	to	to	IN
cord-314013-g091lv0s	16	19	-	-	HYPH
cord-314013-g091lv0s	16	20	human	human	JJ
cord-314013-g091lv0s	16	21	virus	virus	NN
cord-314013-g091lv0s	16	22	transmission	transmission	NN
cord-314013-g091lv0s	16	23	occurs	occur	VBZ
cord-314013-g091lv0s	16	24	through	through	IN
cord-314013-g091lv0s	16	25	an	an	DT
cord-314013-g091lv0s	16	26	interaction	interaction	NN
cord-314013-g091lv0s	16	27	between	between	IN
cord-314013-g091lv0s	16	28	the	the	DT
cord-314013-g091lv0s	16	29	viral	viral	JJ
cord-314013-g091lv0s	16	30	spike	spike	NN
cord-314013-g091lv0s	16	31	glycoprotein	glycoprotein	NN
cord-314013-g091lv0s	16	32	and	and	CC
cord-314013-g091lv0s	16	33	the	the	DT
cord-314013-g091lv0s	16	34	angiotensin	angiotensin	NN
cord-314013-g091lv0s	16	35	-	-	HYPH
cord-314013-g091lv0s	16	36	converting	convert	VBG
cord-314013-g091lv0s	16	37	enzyme	enzyme	NN
cord-314013-g091lv0s	16	38	2	2	CD
cord-314013-g091lv0s	16	39	,	,	,
cord-314013-g091lv0s	16	40	which	which	WDT
cord-314013-g091lv0s	16	41	,	,	,
cord-314013-g091lv0s	16	42	abundantly	abundantly	RB
cord-314013-g091lv0s	16	43	expressed	express	VBN
cord-314013-g091lv0s	16	44	in	in	IN
cord-314013-g091lv0s	16	45	lungs	lung	NNS
cord-314013-g091lv0s	16	46	by	by	IN
cord-314013-g091lv0s	16	47	type-2	type-2	NN
cord-314013-g091lv0s	16	48	alveolar	alveolar	NN
cord-314013-g091lv0s	16	49	epithelial	epithelial	JJ
cord-314013-g091lv0s	16	50	cells	cell	NNS
cord-314013-g091lv0s	16	51	,	,	,
cord-314013-g091lv0s	16	52	is	be	VBZ
cord-314013-g091lv0s	16	53	exploited	exploit	VBN
cord-314013-g091lv0s	16	54	by	by	IN
cord-314013-g091lv0s	16	55	SARS	SARS	NNP
cord-314013-g091lv0s	16	56	-	-	HYPH
cord-314013-g091lv0s	16	57	CoV-2	CoV-2	NNP
cord-314013-g091lv0s	16	58	as	as	IN
cord-314013-g091lv0s	16	59	a	a	DT
cord-314013-g091lv0s	16	60	receptor	receptor	NN
cord-314013-g091lv0s	16	61	to	to	TO
cord-314013-g091lv0s	16	62	enter	enter	VB
cord-314013-g091lv0s	16	63	the	the	DT
cord-314013-g091lv0s	16	64	cell	cell	NN
cord-314013-g091lv0s	17	1	(	(	-LRB-
cord-314013-g091lv0s	17	2	Zhou	Zhou	NNP
cord-314013-g091lv0s	17	3	et	et	NNP
cord-314013-g091lv0s	17	4	al	al	NNP
cord-314013-g091lv0s	17	5	.	.	NNP
cord-314013-g091lv0s	17	6	,	,	,
cord-314013-g091lv0s	17	7	2020	2020	CD
cord-314013-g091lv0s	17	8	)	)	-RRB-
cord-314013-g091lv0s	17	9	.	.	.
cord-314013-g091lv0s	18	1	As	as	IN
cord-314013-g091lv0s	18	2	reported	report	VBN
cord-314013-g091lv0s	18	3	by	by	IN
cord-314013-g091lv0s	18	4	a	a	DT
cord-314013-g091lv0s	18	5	recent	recent	JJ
cord-314013-g091lv0s	18	6	Chinese	chinese	JJ
cord-314013-g091lv0s	18	7	epidemiologic	epidemiologic	JJ
cord-314013-g091lv0s	18	8	study	study	NN
cord-314013-g091lv0s	18	9	(	(	-LRB-
cord-314013-g091lv0s	18	10	Bi	Bi	NNP
cord-314013-g091lv0s	18	11	et	et	FW
cord-314013-g091lv0s	18	12	al	al	NNP
cord-314013-g091lv0s	18	13	.	.	NNP
cord-314013-g091lv0s	18	14	,	,	,
cord-314013-g091lv0s	18	15	2020	2020	CD
cord-314013-g091lv0s	18	16	)	)	-RRB-
cord-314013-g091lv0s	18	17	,	,	,
cord-314013-g091lv0s	18	18	while	while	IN
cord-314013-g091lv0s	18	19	a	a	DT
cord-314013-g091lv0s	18	20	majority	majority	NN
cord-314013-g091lv0s	18	21	of	of	IN
cord-314013-g091lv0s	18	22	COVID-19	COVID-19	NNP
cord-314013-g091lv0s	18	23	cases	case	NNS
cord-314013-g091lv0s	18	24	presents	present	VBZ
cord-314013-g091lv0s	18	25	with	with	IN
cord-314013-g091lv0s	18	26	mild	mild	JJ
cord-314013-g091lv0s	18	27	(	(	-LRB-
cord-314013-g091lv0s	18	28	26	26	CD
cord-314013-g091lv0s	18	29	%	%	NN
cord-314013-g091lv0s	18	30	)	)	-RRB-
cord-314013-g091lv0s	18	31	or	or	CC
cord-314013-g091lv0s	18	32	moderate	moderate	JJ
cord-314013-g091lv0s	18	33	(	(	-LRB-
cord-314013-g091lv0s	18	34	65	65	CD
cord-314013-g091lv0s	18	35	%	%	NN
cord-314013-g091lv0s	18	36	)	)	-RRB-
cord-314013-g091lv0s	18	37	flu	flu	NN
cord-314013-g091lv0s	18	38	-	-	HYPH
cord-314013-g091lv0s	18	39	like	like	JJ
cord-314013-g091lv0s	18	40	symptoms	symptom	NNS
cord-314013-g091lv0s	18	41	,	,	,
cord-314013-g091lv0s	18	42	a	a	DT
cord-314013-g091lv0s	18	43	few	few	JJ
cord-314013-g091lv0s	18	44	patients	patient	NNS
cord-314013-g091lv0s	18	45	(	(	-LRB-
cord-314013-g091lv0s	18	46	9	9	CD
cord-314013-g091lv0s	18	47	%	%	NN
cord-314013-g091lv0s	18	48	)	)	-RRB-
cord-314013-g091lv0s	18	49	,	,	,
cord-314013-g091lv0s	18	50	mostly	mostly	RB
cord-314013-g091lv0s	18	51	the	the	DT
cord-314013-g091lv0s	18	52	elderly	elderly	JJ
cord-314013-g091lv0s	18	53	and/or	and/or	CC
cord-314013-g091lv0s	18	54	with	with	IN
cord-314013-g091lv0s	18	55	preexisting	preexisting	JJ
cord-314013-g091lv0s	18	56	disorders	disorder	NNS
cord-314013-g091lv0s	18	57	,	,	,
cord-314013-g091lv0s	18	58	will	will	MD
cord-314013-g091lv0s	18	59	develop	develop	VB
cord-314013-g091lv0s	18	60	severe	severe	JJ
cord-314013-g091lv0s	18	61	or	or	CC
cord-314013-g091lv0s	18	62	critical	critical	JJ
cord-314013-g091lv0s	18	63	conditions	condition	NNS
cord-314013-g091lv0s	18	64	,	,	,
cord-314013-g091lv0s	18	65	rapidly	rapidly	RB
cord-314013-g091lv0s	18	66	culminating	culminate	VBG
cord-314013-g091lv0s	18	67	in	in	IN
cord-314013-g091lv0s	18	68	an	an	DT
cord-314013-g091lv0s	18	69	acute	acute	JJ
cord-314013-g091lv0s	18	70	respiratory	respiratory	JJ
cord-314013-g091lv0s	18	71	distress	distress	NN
cord-314013-g091lv0s	18	72	syndrome	syndrome	NN
cord-314013-g091lv0s	18	73	(	(	-LRB-
cord-314013-g091lv0s	18	74	RDS	RDS	NNP
cord-314013-g091lv0s	18	75	)	)	-RRB-
cord-314013-g091lv0s	18	76	,	,	,
cord-314013-g091lv0s	18	77	septic	septic	JJ
cord-314013-g091lv0s	18	78	shock	shock	NN
cord-314013-g091lv0s	18	79	,	,	,
cord-314013-g091lv0s	18	80	and	and	CC
cord-314013-g091lv0s	18	81	coagulation	coagulation	NN
cord-314013-g091lv0s	18	82	dysfunction	dysfunction	NN
cord-314013-g091lv0s	18	83	,	,	,
cord-314013-g091lv0s	18	84	all	all	DT
cord-314013-g091lv0s	18	85	of	of	IN
cord-314013-g091lv0s	18	86	which	which	WDT
cord-314013-g091lv0s	18	87	can	can	MD
cord-314013-g091lv0s	18	88	be	be	VB
cord-314013-g091lv0s	18	89	lethal	lethal	JJ
cord-314013-g091lv0s	19	1	(	(	-LRB-
cord-314013-g091lv0s	19	2	Huang	Huang	NNP
cord-314013-g091lv0s	19	3	et	et	NNP
cord-314013-g091lv0s	19	4	al	al	NNP
cord-314013-g091lv0s	19	5	.	.	NNP
cord-314013-g091lv0s	19	6	,	,	,
cord-314013-g091lv0s	19	7	2020	2020	CD
cord-314013-g091lv0s	19	8	)	)	-RRB-
cord-314013-g091lv0s	19	9	.	.	.
cord-314013-g091lv0s	20	1	Disease	Disease	NNP
cord-314013-g091lv0s	20	2	outcome	outcome	NN
cord-314013-g091lv0s	20	3	seems	seem	VBZ
cord-314013-g091lv0s	20	4	to	to	TO
cord-314013-g091lv0s	20	5	critically	critically	RB
cord-314013-g091lv0s	20	6	depend	depend	VB
cord-314013-g091lv0s	20	7	on	on	IN
cord-314013-g091lv0s	20	8	timing	timing	NN
cord-314013-g091lv0s	20	9	and	and	CC
cord-314013-g091lv0s	20	10	strength	strength	NN
cord-314013-g091lv0s	20	11	whereby	whereby	WRB
cord-314013-g091lv0s	20	12	innate	innate	VBP
cord-314013-g091lv0s	20	13	immune	immune	JJ
cord-314013-g091lv0s	20	14	responses	response	NNS
cord-314013-g091lv0s	20	15	against	against	IN
cord-314013-g091lv0s	20	16	the	the	DT
cord-314013-g091lv0s	20	17	virus	virus	NN
cord-314013-g091lv0s	20	18	are	be	VBP
cord-314013-g091lv0s	20	19	activated	activate	VBN
cord-314013-g091lv0s	21	1	(	(	-LRB-
cord-314013-g091lv0s	21	2	Prompetchara	Prompetchara	NNP
cord-314013-g091lv0s	21	3	et	et	NNP
cord-314013-g091lv0s	21	4	al	al	NNP
cord-314013-g091lv0s	21	5	.	.	NNP
cord-314013-g091lv0s	21	6	,	,	,
cord-314013-g091lv0s	21	7	2020	2020	CD
cord-314013-g091lv0s	21	8	)	)	-RRB-
cord-314013-g091lv0s	21	9	.	.	.
cord-314013-g091lv0s	22	1	During	during	IN
cord-314013-g091lv0s	22	2	an	an	DT
cord-314013-g091lv0s	22	3	efficient	efficient	JJ
cord-314013-g091lv0s	22	4	antiviral	antiviral	JJ
cord-314013-g091lv0s	22	5	response	response	NN
cord-314013-g091lv0s	22	6	,	,	,
cord-314013-g091lv0s	22	7	sensing	sensing	NN
cord-314013-g091lv0s	22	8	of	of	IN
cord-314013-g091lv0s	22	9	viral	viral	JJ
cord-314013-g091lv0s	22	10	RNA	RNA	NNP
cord-314013-g091lv0s	22	11	by	by	IN
cord-314013-g091lv0s	22	12	innate	innate	JJ
cord-314013-g091lv0s	22	13	immune	immune	JJ
cord-314013-g091lv0s	22	14	cells	cell	NNS
cord-314013-g091lv0s	22	15	-	-	:
cord-314013-g091lv0s	22	16	a	a	DT
cord-314013-g091lv0s	22	17	first	first	JJ
cord-314013-g091lv0s	22	18	line	line	NN
cord-314013-g091lv0s	22	19	defense	defense	NN
cord-314013-g091lv0s	22	20	against	against	IN
cord-314013-g091lv0s	22	21	the	the	DT
cord-314013-g091lv0s	22	22	pathogen	pathogen	NN
cord-314013-g091lv0s	22	23	-	-	:
cord-314013-g091lv0s	22	24	will	will	MD
cord-314013-g091lv0s	22	25	induce	induce	VB
cord-314013-g091lv0s	22	26	the	the	DT
cord-314013-g091lv0s	22	27	prompt	prompt	JJ
cord-314013-g091lv0s	22	28	expression	expression	NN
cord-314013-g091lv0s	22	29	of	of	IN
cord-314013-g091lv0s	22	30	type	type	NN
cord-314013-g091lv0s	22	31	I	-PRON-	PRP
cord-314013-g091lv0s	22	32	IFN	IFN	NNP
cord-314013-g091lv0s	22	33	,	,	,
cord-314013-g091lv0s	22	34	a	a	DT
cord-314013-g091lv0s	22	35	key	key	JJ
cord-314013-g091lv0s	22	36	cytokine	cytokine	NN
cord-314013-g091lv0s	22	37	capable	capable	JJ
cord-314013-g091lv0s	22	38	of	of	IN
cord-314013-g091lv0s	22	39	suppressing	suppress	VBG
cord-314013-g091lv0s	22	40	replication	replication	NN
cord-314013-g091lv0s	22	41	and	and	CC
cord-314013-g091lv0s	22	42	dissemination	dissemination	NN
cord-314013-g091lv0s	22	43	of	of	IN
cord-314013-g091lv0s	22	44	the	the	DT
cord-314013-g091lv0s	22	45	infecting	infect	VBG
cord-314013-g091lv0s	22	46	pathogen	pathogen	NN
cord-314013-g091lv0s	22	47	at	at	IN
cord-314013-g091lv0s	22	48	an	an	DT
cord-314013-g091lv0s	22	49	early	early	JJ
cord-314013-g091lv0s	22	50	stage	stage	NN
cord-314013-g091lv0s	22	51	.	.	.
cord-314013-g091lv0s	23	1	In	in	IN
cord-314013-g091lv0s	23	2	analogy	analogy	NN
cord-314013-g091lv0s	23	3	with	with	IN
cord-314013-g091lv0s	23	4	SARS	SARS	NNP
cord-314013-g091lv0s	23	5	-	-	:
cord-314013-g091lv0s	23	6	and	and	CC
cord-314013-g091lv0s	23	7	MERS	MERS	NNP
cord-314013-g091lv0s	23	8	-	-	HYPH
cord-314013-g091lv0s	23	9	CoV	CoV	NNP
cord-314013-g091lv0s	23	10	,	,	,
cord-314013-g091lv0s	23	11	SARS	SARS	NNP
cord-314013-g091lv0s	23	12	-	-	HYPH
cord-314013-g091lv0s	23	13	CoV-2	CoV-2	NNP
cord-314013-g091lv0s	23	14	viral	viral	JJ
cord-314013-g091lv0s	23	15	proteins	protein	NNS
cord-314013-g091lv0s	23	16	are	be	VBP
cord-314013-g091lv0s	23	17	thought	think	VBN
cord-314013-g091lv0s	23	18	to	to	TO
cord-314013-g091lv0s	23	19	inhibit	inhibit	VB
cord-314013-g091lv0s	23	20	IFNa	IFNa	NNS
cord-314013-g091lv0s	23	21	receptor	receptor	NN
cord-314013-g091lv0s	23	22	signaling	signaling	NN
cord-314013-g091lv0s	23	23	and	and	CC
cord-314013-g091lv0s	23	24	thus	thus	RB
cord-314013-g091lv0s	23	25	escape	escape	VB
cord-314013-g091lv0s	23	26	the	the	DT
cord-314013-g091lv0s	23	27	early	early	JJ
cord-314013-g091lv0s	23	28	response	response	NN
cord-314013-g091lv0s	23	29	to	to	TO
cord-314013-g091lv0s	23	30	type	type	VB
cord-314013-g091lv0s	23	31	I	-PRON-	PRP
cord-314013-g091lv0s	23	32	IFN	IFN	NNP
cord-314013-g091lv0s	23	33	(	(	-LRB-
cord-314013-g091lv0s	23	34	Perlman	Perlman	NNP
cord-314013-g091lv0s	23	35	and	and	CC
cord-314013-g091lv0s	23	36	Dandekar	Dandekar	NNP
cord-314013-g091lv0s	23	37	,	,	,
cord-314013-g091lv0s	23	38	2005	2005	CD
cord-314013-g091lv0s	23	39	)	)	-RRB-
cord-314013-g091lv0s	23	40	.	.	.
cord-314013-g091lv0s	24	1	A	a	DT
cord-314013-g091lv0s	24	2	subsequent	subsequent	JJ
cord-314013-g091lv0s	24	3	,	,	,
cord-314013-g091lv0s	24	4	uncontrolled	uncontrolled	JJ
cord-314013-g091lv0s	24	5	viral	viral	JJ
cord-314013-g091lv0s	24	6	replication	replication	NN
cord-314013-g091lv0s	24	7	triggers	trigger	VBZ
cord-314013-g091lv0s	24	8	the	the	DT
cord-314013-g091lv0s	24	9	influx	influx	NN
cord-314013-g091lv0s	24	10	of	of	IN
cord-314013-g091lv0s	24	11	neutrophils	neutrophil	NNS
cord-314013-g091lv0s	24	12	and	and	CC
cord-314013-g091lv0s	24	13	monocytes	monocyte	NNS
cord-314013-g091lv0s	24	14	/	/	SYM
cord-314013-g091lv0s	24	15	macrophages	macrophage	NNS
cord-314013-g091lv0s	24	16	into	into	IN
cord-314013-g091lv0s	24	17	the	the	DT
cord-314013-g091lv0s	24	18	lower	low	JJR
cord-314013-g091lv0s	24	19	respiratory	respiratory	JJ
cord-314013-g091lv0s	24	20	tract	tract	NN
cord-314013-g091lv0s	24	21	and	and	CC
cord-314013-g091lv0s	24	22	hyperproduction	hyperproduction	NN
cord-314013-g091lv0s	24	23	of	of	IN
cord-314013-g091lv0s	24	24	chemokines	chemokine	NNS
cord-314013-g091lv0s	24	25	and	and	CC
cord-314013-g091lv0s	24	26	proinflammatory	proinflammatory	JJ
cord-314013-g091lv0s	24	27	cytokines	cytokine	NNS
cord-314013-g091lv0s	24	28	in	in	IN
cord-314013-g091lv0s	24	29	the	the	DT
cord-314013-g091lv0s	24	30	local	local	JJ
cord-314013-g091lv0s	24	31	environment	environment	NN
cord-314013-g091lv0s	24	32	,	,	,
cord-314013-g091lv0s	24	33	including	include	VBG
cord-314013-g091lv0s	24	34	IL-6	IL-6	NNP
cord-314013-g091lv0s	24	35	,	,	,
cord-314013-g091lv0s	24	36	IL-10	IL-10	NNP
cord-314013-g091lv0s	24	37	,	,	,
cord-314013-g091lv0s	24	38	and	and	CC
cord-314013-g091lv0s	24	39	TNFa	TNFa	NNS
cord-314013-g091lv0s	24	40	,	,	,
cord-314013-g091lv0s	24	41	causing	cause	VBG
cord-314013-g091lv0s	24	42	a	a	DT
cord-314013-g091lv0s	24	43	"	"	``
cord-314013-g091lv0s	24	44	cytokine	cytokine	NN
cord-314013-g091lv0s	24	45	storm	storm	NN
cord-314013-g091lv0s	24	46	"	"	''
cord-314013-g091lv0s	24	47	(	(	-LRB-
cord-314013-g091lv0s	24	48	Huang	Huang	NNP
cord-314013-g091lv0s	24	49	et	et	FW
cord-314013-g091lv0s	24	50	al	al	NNP
cord-314013-g091lv0s	24	51	.	.	NNP
cord-314013-g091lv0s	24	52	,	,	,
cord-314013-g091lv0s	24	53	2020	2020	CD
cord-314013-g091lv0s	24	54	)	)	-RRB-
cord-314013-g091lv0s	24	55	.	.	.
cord-314013-g091lv0s	25	1	Therefore	therefore	RB
cord-314013-g091lv0s	25	2	,	,	,
cord-314013-g091lv0s	25	3	the	the	DT
cord-314013-g091lv0s	25	4	more	more	RBR
cord-314013-g091lv0s	25	5	the	the	DT
cord-314013-g091lv0s	25	6	virus	virus	NN
cord-314013-g091lv0s	25	7	is	be	VBZ
cord-314013-g091lv0s	25	8	able	able	JJ
cord-314013-g091lv0s	25	9	to	to	TO
cord-314013-g091lv0s	25	10	contrast	contrast	VB
cord-314013-g091lv0s	25	11	type	type	NN
cord-314013-g091lv0s	26	1	I	-PRON-	PRP
cord-314013-g091lv0s	26	2	IFN	IFN	NNP
cord-314013-g091lv0s	26	3	production	production	NN
cord-314013-g091lv0s	26	4	(	(	-LRB-
cord-314013-g091lv0s	26	5	by	by	IN
cord-314013-g091lv0s	26	6	delaying	delay	VBG
cord-314013-g091lv0s	26	7	and	and	CC
cord-314013-g091lv0s	26	8	weakening	weaken	VBG
cord-314013-g091lv0s	26	9	this	this	DT
cord-314013-g091lv0s	26	10	response	response	NN
cord-314013-g091lv0s	26	11	)	)	-RRB-
cord-314013-g091lv0s	26	12	,	,	,
cord-314013-g091lv0s	26	13	the	the	DT
cord-314013-g091lv0s	26	14	more	more	RBR
cord-314013-g091lv0s	26	15	an	an	DT
cord-314013-g091lv0s	26	16	overwhelming	overwhelming	JJ
cord-314013-g091lv0s	26	17	inflammatory	inflammatory	JJ
cord-314013-g091lv0s	26	18	response	response	NN
cord-314013-g091lv0s	26	19	will	will	MD
cord-314013-g091lv0s	26	20	be	be	VB
cord-314013-g091lv0s	26	21	mounted	mount	VBN
cord-314013-g091lv0s	26	22	in	in	IN
cord-314013-g091lv0s	26	23	the	the	DT
cord-314013-g091lv0s	26	24	lungs	lung	NNS
cord-314013-g091lv0s	26	25	,	,	,
cord-314013-g091lv0s	26	26	the	the	DT
cord-314013-g091lv0s	26	27	main	main	JJ
cord-314013-g091lv0s	26	28	target	target	NN
cord-314013-g091lv0s	26	29	organ	organ	NN
cord-314013-g091lv0s	26	30	of	of	IN
cord-314013-g091lv0s	26	31	SARS	SARS	NNP
cord-314013-g091lv0s	26	32	-	-	HYPH
cord-314013-g091lv0s	26	33	CoV-2	CoV-2	NNP
cord-314013-g091lv0s	27	1	(	(	-LRB-
cord-314013-g091lv0s	27	2	Prompetchara	Prompetchara	NNP
cord-314013-g091lv0s	27	3	et	et	NNP
cord-314013-g091lv0s	27	4	al	al	NNP
cord-314013-g091lv0s	27	5	.	.	NNP
cord-314013-g091lv0s	27	6	,	,	,
cord-314013-g091lv0s	27	7	2020	2020	CD
cord-314013-g091lv0s	27	8	)	)	-RRB-
cord-314013-g091lv0s	27	9	.	.	.
cord-314013-g091lv0s	28	1	If	if	IN
cord-314013-g091lv0s	28	2	a	a	DT
cord-314013-g091lv0s	28	3	cytokine	cytokine	NN
cord-314013-g091lv0s	28	4	storm	storm	NN
cord-314013-g091lv0s	28	5	occurs	occur	VBZ
cord-314013-g091lv0s	28	6	,	,	,
cord-314013-g091lv0s	28	7	the	the	DT
cord-314013-g091lv0s	28	8	ensuing	ensue	VBG
cord-314013-g091lv0s	28	9	cytokine	cytokine	NN
cord-314013-g091lv0s	28	10	release	release	NN
cord-314013-g091lv0s	28	11	syndrome	syndrome	NN
cord-314013-g091lv0s	28	12	(	(	-LRB-
cord-314013-g091lv0s	28	13	CRS	CRS	NNP
cord-314013-g091lv0s	28	14	)	)	-RRB-
cord-314013-g091lv0s	28	15	is	be	VBZ
cord-314013-g091lv0s	28	16	typically	typically	RB
cord-314013-g091lv0s	28	17	associated	associate	VBN
cord-314013-g091lv0s	28	18	with	with	IN
cord-314013-g091lv0s	28	19	severe	severe	JJ
cord-314013-g091lv0s	28	20	,	,	,
cord-314013-g091lv0s	28	21	rather	rather	RB
cord-314013-g091lv0s	28	22	than	than	IN
cord-314013-g091lv0s	28	23	moderate	moderate	JJ
cord-314013-g091lv0s	28	24	,	,	,
cord-314013-g091lv0s	28	25	COVID-19	COVID-19	NNP
cord-314013-g091lv0s	28	26	,	,	,
cord-314013-g091lv0s	28	27	with	with	IN
cord-314013-g091lv0s	28	28	an	an	DT
cord-314013-g091lv0s	28	29	immunopathology	immunopathology	NN
cord-314013-g091lv0s	28	30	being	be	VBG
cord-314013-g091lv0s	28	31	characterized	characterize	VBN
cord-314013-g091lv0s	28	32	by	by	IN
cord-314013-g091lv0s	28	33	high	high	JJ
cord-314013-g091lv0s	28	34	serum	serum	NN
cord-314013-g091lv0s	28	35	levels	level	NNS
cord-314013-g091lv0s	28	36	of	of	IN
cord-314013-g091lv0s	28	37	cytokines	cytokine	NNS
cord-314013-g091lv0s	28	38	,	,	,
cord-314013-g091lv0s	28	39	CD4	CD4	NNP
cord-314013-g091lv0s	28	40	+	+	CC
cord-314013-g091lv0s	28	41	and	and	CC
cord-314013-g091lv0s	28	42	CD8	CD8	NNP
cord-314013-g091lv0s	28	43	+	+	CC
cord-314013-g091lv0s	28	44	T	T	NNP
cord-314013-g091lv0s	28	45	(	(	-LRB-
cord-314013-g091lv0s	28	46	but	but	CC
cord-314013-g091lv0s	28	47	not	not	RB
cord-314013-g091lv0s	28	48	B	b	NN
cord-314013-g091lv0s	28	49	)	)	-RRB-
cord-314013-g091lv0s	28	50	cell	cell	NN
cord-314013-g091lv0s	28	51	lymphopenia	lymphopenia	NNP
cord-314013-g091lv0s	28	52	,	,	,
cord-314013-g091lv0s	28	53	diffused	diffuse	VBN
cord-314013-g091lv0s	28	54	alveolar	alveolar	JJ
cord-314013-g091lv0s	28	55	damage	damage	NN
cord-314013-g091lv0s	28	56	,	,	,
cord-314013-g091lv0s	28	57	pulmonary	pulmonary	JJ
cord-314013-g091lv0s	28	58	hypertension	hypertension	NN
cord-314013-g091lv0s	28	59	,	,	,
cord-314013-g091lv0s	28	60	pneumonia	pneumonia	NN
cord-314013-g091lv0s	28	61	,	,	,
cord-314013-g091lv0s	28	62	and	and	CC
cord-314013-g091lv0s	28	63	acute	acute	JJ
cord-314013-g091lv0s	28	64	RDS	RDS	NNP
cord-314013-g091lv0s	28	65	(	(	-LRB-
cord-314013-g091lv0s	28	66	Pedersen	Pedersen	NNP
cord-314013-g091lv0s	28	67	and	and	CC
cord-314013-g091lv0s	28	68	Ho	Ho	NNP
cord-314013-g091lv0s	28	69	,	,	,
cord-314013-g091lv0s	28	70	2020	2020	CD
cord-314013-g091lv0s	28	71	)	)	-RRB-
cord-314013-g091lv0s	28	72	.	.	.
cord-314013-g091lv0s	29	1	Among	among	IN
cord-314013-g091lv0s	29	2	pro	pro	JJ
cord-314013-g091lv0s	29	3	-	-	JJ
cord-314013-g091lv0s	29	4	inflammatory	inflammatory	JJ
cord-314013-g091lv0s	29	5	cytokines	cytokine	NNS
cord-314013-g091lv0s	29	6	in	in	IN
cord-314013-g091lv0s	29	7	a	a	DT
cord-314013-g091lv0s	29	8	cytokine	cytokine	NN
cord-314013-g091lv0s	29	9	storm	storm	NN
cord-314013-g091lv0s	29	10	,	,	,
cord-314013-g091lv0s	29	11	IL-6	IL-6	NNP
cord-314013-g091lv0s	29	12	plays	play	VBZ
cord-314013-g091lv0s	29	13	a	a	DT
cord-314013-g091lv0s	29	14	key	key	JJ
cord-314013-g091lv0s	29	15	role	role	NN
cord-314013-g091lv0s	29	16	in	in	IN
cord-314013-g091lv0s	29	17	inducing	induce	VBG
cord-314013-g091lv0s	29	18	acute	acute	JJ
cord-314013-g091lv0s	29	19	inflammation	inflammation	NN
cord-314013-g091lv0s	29	20	,	,	,
cord-314013-g091lv0s	29	21	as	as	IN
cord-314013-g091lv0s	29	22	the	the	DT
cord-314013-g091lv0s	29	23	one	one	NN
cord-314013-g091lv0s	29	24	observed	observe	VBD
cord-314013-g091lv0s	29	25	in	in	IN
cord-314013-g091lv0s	29	26	RDS	RDS	NNP
cord-314013-g091lv0s	29	27	.	.	.
cord-314013-g091lv0s	30	1	IL-6	IL-6	NNP
cord-314013-g091lv0s	30	2	is	be	VBZ
cord-314013-g091lv0s	30	3	a	a	DT
cord-314013-g091lv0s	30	4	monomeric	monomeric	JJ
cord-314013-g091lv0s	30	5	cytokine	cytokine	NN
cord-314013-g091lv0s	30	6	produced	produce	VBN
cord-314013-g091lv0s	30	7	by	by	IN
cord-314013-g091lv0s	30	8	almost	almost	RB
cord-314013-g091lv0s	30	9	all	all	DT
cord-314013-g091lv0s	30	10	stromal	stromal	JJ
cord-314013-g091lv0s	30	11	and	and	CC
cord-314013-g091lv0s	30	12	immune	immune	JJ
cord-314013-g091lv0s	30	13	cells	cell	NNS
cord-314013-g091lv0s	30	14	in	in	IN
cord-314013-g091lv0s	30	15	response	response	NN
cord-314013-g091lv0s	30	16	to	to	IN
cord-314013-g091lv0s	30	17	infection	infection	NN
cord-314013-g091lv0s	30	18	or	or	CC
cord-314013-g091lv0s	30	19	tissue	tissue	NN
cord-314013-g091lv0s	30	20	injury	injury	NN
cord-314013-g091lv0s	30	21	.	.	.
cord-314013-g091lv0s	31	1	In	in	IN
cord-314013-g091lv0s	31	2	particular	particular	JJ
cord-314013-g091lv0s	31	3	,	,	,
cord-314013-g091lv0s	31	4	neutrophils	neutrophil	NNS
cord-314013-g091lv0s	31	5	,	,	,
cord-314013-g091lv0s	31	6	monocytes	monocyte	NNS
cord-314013-g091lv0s	31	7	,	,	,
cord-314013-g091lv0s	31	8	and	and	CC
cord-314013-g091lv0s	31	9	macrophages	macrophage	NNS
cord-314013-g091lv0s	31	10	release	release	VBP
cord-314013-g091lv0s	31	11	IL-6	IL-6	NNP
cord-314013-g091lv0s	31	12	and	and	CC
cord-314013-g091lv0s	31	13	other	other	JJ
cord-314013-g091lv0s	31	14	proinflammatory	proinflammatory	JJ
cord-314013-g091lv0s	31	15	cytokines	cytokine	NNS
cord-314013-g091lv0s	31	16	(	(	-LRB-
cord-314013-g091lv0s	31	17	IL-1b	IL-1b	NNP
cord-314013-g091lv0s	31	18	and	and	CC
cord-314013-g091lv0s	31	19	TNFa	TNFa	NNP
cord-314013-g091lv0s	31	20	)	)	-RRB-
cord-314013-g091lv0s	31	21	,	,	,
cord-314013-g091lv0s	31	22	as	as	IN
cord-314013-g091lv0s	31	23	an	an	DT
cord-314013-g091lv0s	31	24	event	event	NN
cord-314013-g091lv0s	31	25	downstream	downstream	NN
cord-314013-g091lv0s	31	26	of	of	IN
cord-314013-g091lv0s	31	27	toll	toll	NN
cord-314013-g091lv0s	31	28	-	-	HYPH
cord-314013-g091lv0s	31	29	like	like	JJ
cord-314013-g091lv0s	31	30	receptor	receptor	NN
cord-314013-g091lv0s	31	31	sensing	sensing	NN
cord-314013-g091lv0s	31	32	of	of	IN
cord-314013-g091lv0s	31	33	pathogens	pathogen	NNS
cord-314013-g091lv0s	31	34	.	.	.
cord-314013-g091lv0s	32	1	IL-6	IL-6	NNP
cord-314013-g091lv0s	32	2	signaling	signaling	NN
cord-314013-g091lv0s	32	3	occurs	occur	VBZ
cord-314013-g091lv0s	32	4	through	through	IN
cord-314013-g091lv0s	32	5	two	two	CD
cord-314013-g091lv0s	32	6	pathways	pathway	NNS
cord-314013-g091lv0s	32	7	:	:	:
cord-314013-g091lv0s	32	8	the	the	DT
cord-314013-g091lv0s	32	9	cytokine	cytokine	NN
cord-314013-g091lv0s	32	10	binds	bind	VBZ
cord-314013-g091lv0s	32	11	the	the	DT
cord-314013-g091lv0s	32	12	transmembrane	transmembrane	NN
cord-314013-g091lv0s	32	13	type	type	NN
cord-314013-g091lv0s	32	14	-	-	:
cord-314013-g091lv0s	32	15	I	i	NN
cord-314013-g091lv0s	32	16	receptor	receptor	NN
cord-314013-g091lv0s	32	17	IL-6R	IL-6R	NNP
cord-314013-g091lv0s	32	18	(	(	-LRB-
cord-314013-g091lv0s	32	19	i.e.	i.e.	FW
cord-314013-g091lv0s	32	20	,	,	,
cord-314013-g091lv0s	32	21	the	the	DT
cord-314013-g091lv0s	32	22	classical	classical	JJ
cord-314013-g091lv0s	32	23	pathway	pathway	NN
cord-314013-g091lv0s	32	24	,	,	,
cord-314013-g091lv0s	32	25	mediating	mediate	VBG
cord-314013-g091lv0s	32	26	regenerative	regenerative	JJ
cord-314013-g091lv0s	32	27	and	and	CC
cord-314013-g091lv0s	32	28	anti	anti	JJ
cord-314013-g091lv0s	32	29	-	-	JJ
cord-314013-g091lv0s	32	30	bacterial	bacterial	JJ
cord-314013-g091lv0s	32	31	protective	protective	JJ
cord-314013-g091lv0s	32	32	effects	effect	NNS
cord-314013-g091lv0s	32	33	)	)	-RRB-
cord-314013-g091lv0s	32	34	,	,	,
cord-314013-g091lv0s	32	35	or	or	CC
cord-314013-g091lv0s	32	36	it	-PRON-	PRP
cord-314013-g091lv0s	32	37	binds	bind	VBZ
cord-314013-g091lv0s	32	38	the	the	DT
cord-314013-g091lv0s	32	39	soluble	soluble	JJ
cord-314013-g091lv0s	32	40	form	form	NN
cord-314013-g091lv0s	32	41	of	of	IN
cord-314013-g091lv0s	32	42	the	the	DT
cord-314013-g091lv0s	32	43	receptor	receptor	NN
cord-314013-g091lv0s	32	44	(	(	-LRB-
cord-314013-g091lv0s	32	45	i.e.	i.e.	FW
cord-314013-g091lv0s	32	46	,	,	,
cord-314013-g091lv0s	32	47	the	the	DT
cord-314013-g091lv0s	32	48	trans	trans	NN
cord-314013-g091lv0s	32	49	-	-	JJ
cord-314013-g091lv0s	32	50	signaling	signal	VBG
cord-314013-g091lv0s	32	51	pathway	pathway	NN
cord-314013-g091lv0s	32	52	,	,	,
cord-314013-g091lv0s	32	53	inducing	induce	VBG
cord-314013-g091lv0s	32	54	inflammatory	inflammatory	JJ
cord-314013-g091lv0s	32	55	mediators	mediator	NNS
cord-314013-g091lv0s	32	56	)	)	-RRB-
cord-314013-g091lv0s	32	57	.	.	.
cord-314013-g091lv0s	33	1	Both	both	DT
cord-314013-g091lv0s	33	2	pathways	pathway	NNS
cord-314013-g091lv0s	33	3	converge	converge	VBP
cord-314013-g091lv0s	33	4	on	on	IN
cord-314013-g091lv0s	33	5	the	the	DT
cord-314013-g091lv0s	33	6	association	association	NN
cord-314013-g091lv0s	33	7	with	with	IN
cord-314013-g091lv0s	33	8	the	the	DT
cord-314013-g091lv0s	33	9	same	same	JJ
cord-314013-g091lv0s	33	10	transmembrane	transmembrane	NN
cord-314013-g091lv0s	33	11	gp130-homodimer	gp130-homodimer	NNPS
cord-314013-g091lv0s	33	12	to	to	TO
cord-314013-g091lv0s	33	13	assemble	assemble	VB
cord-314013-g091lv0s	33	14	the	the	DT
cord-314013-g091lv0s	33	15	active	active	JJ
cord-314013-g091lv0s	33	16	receptor	receptor	NN
cord-314013-g091lv0s	33	17	complex	complex	NN
cord-314013-g091lv0s	33	18	,	,	,
cord-314013-g091lv0s	33	19	which	which	WDT
cord-314013-g091lv0s	33	20	exploits	exploit	VBZ
cord-314013-g091lv0s	33	21	the	the	DT
cord-314013-g091lv0s	33	22	JAK	JAK	NNP
cord-314013-g091lv0s	33	23	/	/	SYM
cord-314013-g091lv0s	33	24	STAT	stat	NN
cord-314013-g091lv0s	33	25	pathway	pathway	NN
cord-314013-g091lv0s	33	26	for	for	IN
cord-314013-g091lv0s	33	27	signal	signal	NN
cord-314013-g091lv0s	33	28	transduction	transduction	NN
cord-314013-g091lv0s	34	1	(	(	-LRB-
cord-314013-g091lv0s	34	2	Rose	Rose	NNP
cord-314013-g091lv0s	34	3	-	-	HYPH
cord-314013-g091lv0s	34	4	John	John	NNP
cord-314013-g091lv0s	34	5	,	,	,
cord-314013-g091lv0s	34	6	2012	2012	CD
cord-314013-g091lv0s	34	7	)	)	-RRB-
cord-314013-g091lv0s	34	8	.	.	.
cord-314013-g091lv0s	35	1	The	the	DT
cord-314013-g091lv0s	35	2	potent	potent	JJ
cord-314013-g091lv0s	35	3	proinflammatory	proinflammatory	JJ
cord-314013-g091lv0s	35	4	IL-6	IL-6	NNP
cord-314013-g091lv0s	35	5	cascade	cascade	NN
cord-314013-g091lv0s	35	6	is	be	VBZ
cord-314013-g091lv0s	35	7	regulated	regulate	VBN
cord-314013-g091lv0s	35	8	by	by	IN
cord-314013-g091lv0s	35	9	natural	natural	JJ
cord-314013-g091lv0s	35	10	inhibitors	inhibitor	NNS
cord-314013-g091lv0s	35	11	,	,	,
cord-314013-g091lv0s	35	12	interfering	interfere	VBG
cord-314013-g091lv0s	35	13	with	with	IN
cord-314013-g091lv0s	35	14	the	the	DT
cord-314013-g091lv0s	35	15	complete	complete	JJ
cord-314013-g091lv0s	35	16	assembly	assembly	NN
cord-314013-g091lv0s	35	17	of	of	IN
cord-314013-g091lv0s	35	18	the	the	DT
cord-314013-g091lv0s	35	19	functional	functional	JJ
cord-314013-g091lv0s	35	20	receptor	receptor	NN
cord-314013-g091lv0s	35	21	(	(	-LRB-
cord-314013-g091lv0s	35	22	gp130	gp130	NNS
cord-314013-g091lv0s	35	23	soluble	soluble	JJ
cord-314013-g091lv0s	35	24	form	form	NN
cord-314013-g091lv0s	35	25	)	)	-RRB-
cord-314013-g091lv0s	35	26	,	,	,
cord-314013-g091lv0s	35	27	or	or	CC
cord-314013-g091lv0s	35	28	with	with	IN
cord-314013-g091lv0s	35	29	its	-PRON-	PRP$
cord-314013-g091lv0s	35	30	signal	signal	NN
cord-314013-g091lv0s	35	31	transduction	transduction	NN
cord-314013-g091lv0s	35	32	system	system	NN
cord-314013-g091lv0s	35	33	(	(	-LRB-
cord-314013-g091lv0s	35	34	i.e.	i.e.	FW
cord-314013-g091lv0s	35	35	,	,	,
cord-314013-g091lv0s	35	36	SOCS	SOCS	NNP
cord-314013-g091lv0s	35	37	proteins	protein	NNS
cord-314013-g091lv0s	35	38	)	)	-RRB-
cord-314013-g091lv0s	35	39	.	.	.
cord-314013-g091lv0s	36	1	The	the	DT
cord-314013-g091lv0s	36	2	recombinant	recombinant	JJ
cord-314013-g091lv0s	36	3	human	human	JJ
cord-314013-g091lv0s	36	4	monoclonal	monoclonal	JJ
cord-314013-g091lv0s	36	5	antibody	antibody	NN
cord-314013-g091lv0s	36	6	TCZ	TCZ	NNP
cord-314013-g091lv0s	36	7	,	,	,
cord-314013-g091lv0s	36	8	directed	direct	VBN
cord-314013-g091lv0s	36	9	against	against	IN
cord-314013-g091lv0s	36	10	the	the	DT
cord-314013-g091lv0s	36	11	IL-6R	IL-6R	NNP
cord-314013-g091lv0s	36	12	,	,	,
cord-314013-g091lv0s	36	13	mediates	mediate	VBZ
cord-314013-g091lv0s	36	14	an	an	DT
cord-314013-g091lv0s	36	15	inhibition	inhibition	NN
cord-314013-g091lv0s	36	16	strategy	strategy	NN
cord-314013-g091lv0s	36	17	,	,	,
cord-314013-g091lv0s	36	18	preventing	prevent	VBG
cord-314013-g091lv0s	36	19	IL-6	IL-6	NNP
cord-314013-g091lv0s	36	20	binding	bind	VBG
cord-314013-g091lv0s	36	21	to	to	IN
cord-314013-g091lv0s	36	22	its	-PRON-	PRP$
cord-314013-g091lv0s	36	23	receptor	receptor	NN
cord-314013-g091lv0s	36	24	and	and	CC
cord-314013-g091lv0s	36	25	therefore	therefore	RB
cord-314013-g091lv0s	36	26	IL-6	IL-6	NNP
cord-314013-g091lv0s	36	27	biological	biological	JJ
cord-314013-g091lv0s	36	28	activity	activity	NN
cord-314013-g091lv0s	36	29	.	.	.
cord-314013-g091lv0s	37	1	Preferentially	preferentially	RB
cord-314013-g091lv0s	37	2	interacting	interact	VBG
cord-314013-g091lv0s	37	3	with	with	IN
cord-314013-g091lv0s	37	4	soluble	soluble	JJ
cord-314013-g091lv0s	37	5	rather	rather	RB
cord-314013-g091lv0s	37	6	than	than	IN
cord-314013-g091lv0s	37	7	transmembrane	transmembrane	JJ
cord-314013-g091lv0s	37	8	IL-6R	IL-6R	NNP
cord-314013-g091lv0s	37	9	,	,	,
cord-314013-g091lv0s	37	10	the	the	DT
cord-314013-g091lv0s	37	11	biological	biological	JJ
cord-314013-g091lv0s	37	12	drug	drug	NN
cord-314013-g091lv0s	37	13	mainly	mainly	RB
cord-314013-g091lv0s	37	14	opposes	oppose	VBZ
cord-314013-g091lv0s	37	15	inflammatory	inflammatory	JJ
cord-314013-g091lv0s	37	16	more	more	JJR
cord-314013-g091lv0s	37	17	than	than	IN
cord-314013-g091lv0s	37	18	regenerative	regenerative	JJ
cord-314013-g091lv0s	37	19	responses	response	NNS
cord-314013-g091lv0s	37	20	to	to	IN
cord-314013-g091lv0s	37	21	IL-6	IL-6	NNP
cord-314013-g091lv0s	37	22	(	(	-LRB-
cord-314013-g091lv0s	37	23	Sheppard	Sheppard	NNP
cord-314013-g091lv0s	37	24	et	et	NNP
cord-314013-g091lv0s	37	25	al	al	NNP
cord-314013-g091lv0s	37	26	.	.	NNP
cord-314013-g091lv0s	37	27	,	,	,
cord-314013-g091lv0s	37	28	2017	2017	CD
cord-314013-g091lv0s	37	29	)	)	-RRB-
cord-314013-g091lv0s	37	30	.	.	.
cord-314013-g091lv0s	38	1	Because	because	IN
cord-314013-g091lv0s	38	2	of	of	IN
cord-314013-g091lv0s	38	3	its	-PRON-	PRP$
cord-314013-g091lv0s	38	4	peculiar	peculiar	JJ
cord-314013-g091lv0s	38	5	action	action	NN
cord-314013-g091lv0s	38	6	impairing	impair	VBG
cord-314013-g091lv0s	38	7	IL-6-mediated	il-6-mediated	JJ
cord-314013-g091lv0s	38	8	pathogenic	pathogenic	JJ
cord-314013-g091lv0s	38	9	immunity	immunity	NN
cord-314013-g091lv0s	38	10	,	,	,
cord-314013-g091lv0s	38	11	FDA	FDA	NNP
cord-314013-g091lv0s	38	12	currently	currently	RB
cord-314013-g091lv0s	38	13	approves	approve	VBZ
cord-314013-g091lv0s	38	14	TCZ	tcz	NN
cord-314013-g091lv0s	38	15	for	for	IN
cord-314013-g091lv0s	38	16	treatment	treatment	NN
cord-314013-g091lv0s	38	17	of	of	IN
cord-314013-g091lv0s	38	18	adult	adult	JJ
cord-314013-g091lv0s	38	19	rheumatoid	rheumatoid	NN
cord-314013-g091lv0s	38	20	arthritis	arthritis	NN
cord-314013-g091lv0s	38	21	,	,	,
cord-314013-g091lv0s	38	22	large	large	JJ
cord-314013-g091lv0s	38	23	-	-	HYPH
cord-314013-g091lv0s	38	24	vessel	vessel	NN
cord-314013-g091lv0s	38	25	vasculitis	vasculitis	NN
cord-314013-g091lv0s	38	26	,	,	,
cord-314013-g091lv0s	38	27	such	such	JJ
cord-314013-g091lv0s	38	28	as	as	IN
cord-314013-g091lv0s	38	29	giant	giant	JJ
cord-314013-g091lv0s	38	30	-	-	HYPH
cord-314013-g091lv0s	38	31	cell	cell	NN
cord-314013-g091lv0s	38	32	arteritis	arteritis	NN
cord-314013-g091lv0s	38	33	,	,	,
cord-314013-g091lv0s	38	34	polyarticular	polyarticular	JJ
cord-314013-g091lv0s	38	35	juvenile	juvenile	JJ
cord-314013-g091lv0s	38	36	idiopathic	idiopathic	JJ
cord-314013-g091lv0s	38	37	arthritis	arthritis	NN
cord-314013-g091lv0s	38	38	,	,	,
cord-314013-g091lv0s	38	39	systemic	systemic	JJ
cord-314013-g091lv0s	38	40	juvenile	juvenile	JJ
cord-314013-g091lv0s	38	41	idiopathic	idiopathic	JJ
cord-314013-g091lv0s	38	42	arthritis	arthritis	NN
cord-314013-g091lv0s	38	43	,	,	,
cord-314013-g091lv0s	38	44	adult	adult	NN
cord-314013-g091lv0s	38	45	-	-	HYPH
cord-314013-g091lv0s	38	46	onset	onset	NN
cord-314013-g091lv0s	39	1	Still	still	RB
cord-314013-g091lv0s	39	2	's	's	POS
cord-314013-g091lv0s	39	3	disease	disease	NN
cord-314013-g091lv0s	39	4	,	,	,
cord-314013-g091lv0s	39	5	and	and	CC
cord-314013-g091lv0s	39	6	the	the	DT
cord-314013-g091lv0s	39	7	severe	severe	JJ
cord-314013-g091lv0s	39	8	often	often	RB
cord-314013-g091lv0s	39	9	life	life	NN
cord-314013-g091lv0s	39	10	-	-	HYPH
cord-314013-g091lv0s	39	11	threatening	threaten	VBG
cord-314013-g091lv0s	39	12	CRS	CRS	NNP
cord-314013-g091lv0s	39	13	induced	induce	VBN
cord-314013-g091lv0s	39	14	by	by	IN
cord-314013-g091lv0s	39	15	chimeric	chimeric	JJ
cord-314013-g091lv0s	39	16	antigen	antigen	NN
cord-314013-g091lv0s	39	17	receptor	receptor	NN
cord-314013-g091lv0s	39	18	T	t	NN
cord-314013-g091lv0s	39	19	cell	cell	NN
cord-314013-g091lv0s	39	20	therapy	therapy	NN
cord-314013-g091lv0s	39	21	.	.	.
cord-314013-g091lv0s	40	1	Current	current	JJ
cord-314013-g091lv0s	40	2	clinical	clinical	JJ
cord-314013-g091lv0s	40	3	trials	trial	NNS
cord-314013-g091lv0s	40	4	include	include	VBP
cord-314013-g091lv0s	40	5	vascular	vascular	JJ
cord-314013-g091lv0s	40	6	and	and	CC
cord-314013-g091lv0s	40	7	muscular	muscular	JJ
cord-314013-g091lv0s	40	8	diseases	disease	NNS
cord-314013-g091lv0s	40	9	characterized	characterize	VBN
cord-314013-g091lv0s	40	10	by	by	IN
cord-314013-g091lv0s	40	11	strong	strong	JJ
cord-314013-g091lv0s	40	12	inflammatory	inflammatory	JJ
cord-314013-g091lv0s	40	13	and	and	CC
cord-314013-g091lv0s	40	14	autoimmune	autoimmune	JJ
cord-314013-g091lv0s	40	15	components	component	NNS
cord-314013-g091lv0s	40	16	,	,	,
cord-314013-g091lv0s	40	17	and	and	CC
cord-314013-g091lv0s	40	18	specific	specific	JJ
cord-314013-g091lv0s	40	19	autoimmune	autoimmune	JJ
cord-314013-g091lv0s	40	20	diseases	disease	NNS
cord-314013-g091lv0s	40	21	,	,	,
cord-314013-g091lv0s	40	22	such	such	JJ
cord-314013-g091lv0s	40	23	as	as	IN
cord-314013-g091lv0s	40	24	type	type	NN
cord-314013-g091lv0s	40	25	1	1	CD
cord-314013-g091lv0s	40	26	diabetes	diabete	NNS
cord-314013-g091lv0s	40	27	,	,	,
cord-314013-g091lv0s	40	28	as	as	IN
cord-314013-g091lv0s	40	29	being	be	VBG
cord-314013-g091lv0s	40	30	evaluated	evaluate	VBN
cord-314013-g091lv0s	40	31	in	in	IN
cord-314013-g091lv0s	40	32	an	an	DT
cord-314013-g091lv0s	40	33	extended	extended	JJ
cord-314013-g091lv0s	40	34	clinical	clinical	JJ
cord-314013-g091lv0s	40	35	trial	trial	NN
cord-314013-g091lv0s	40	36	(	(	-LRB-
cord-314013-g091lv0s	40	37	EXTEND	extend	VB
cord-314013-g091lv0s	40	38	,	,	,
cord-314013-g091lv0s	40	39	NCT02293837	nct02293837	NN
cord-314013-g091lv0s	40	40	)	)	-RRB-
cord-314013-g091lv0s	40	41	.	.	.
cord-314013-g091lv0s	41	1	Awareness	awareness	NN
cord-314013-g091lv0s	41	2	of	of	IN
cord-314013-g091lv0s	41	3	IL-6	IL-6	NNP
cord-314013-g091lv0s	41	4	's	's	POS
cord-314013-g091lv0s	41	5	potential	potential	JJ
cord-314013-g091lv0s	41	6	role	role	NN
cord-314013-g091lv0s	41	7	in	in	IN
cord-314013-g091lv0s	41	8	COVID-19	COVID-19	NNP
cord-314013-g091lv0s	41	9	immunopathogenesis	immunopathogenesis	NNP
cord-314013-g091lv0s	41	10	prompted	prompt	VBD
cord-314013-g091lv0s	41	11	new	new	JJ
cord-314013-g091lv0s	41	12	clinical	clinical	JJ
cord-314013-g091lv0s	41	13	trials	trial	NNS
cord-314013-g091lv0s	41	14	aimed	aim	VBN
cord-314013-g091lv0s	41	15	at	at	IN
cord-314013-g091lv0s	41	16	assessing	assess	VBG
cord-314013-g091lv0s	41	17	TCZ	TCZ	NNP
cord-314013-g091lv0s	41	18	efficacy	efficacy	NN
cord-314013-g091lv0s	41	19	in	in	IN
cord-314013-g091lv0s	41	20	COVID-19	COVID-19	NNP
cord-314013-g091lv0s	41	21	.	.	.
cord-314013-g091lv0s	42	1	While	while	IN
cord-314013-g091lv0s	42	2	awaiting	await	VBG
cord-314013-g091lv0s	42	3	a	a	DT
cord-314013-g091lv0s	42	4	vaccine	vaccine	NN
cord-314013-g091lv0s	42	5	to	to	TO
cord-314013-g091lv0s	42	6	constrain	constrain	VB
cord-314013-g091lv0s	42	7	the	the	DT
cord-314013-g091lv0s	42	8	pandemic	pandemic	NN
cord-314013-g091lv0s	42	9	,	,	,
cord-314013-g091lv0s	42	10	IL-6	IL-6	NNP
cord-314013-g091lv0s	42	11	blockade	blockade	NN
cord-314013-g091lv0s	42	12	seems	seem	VBZ
cord-314013-g091lv0s	42	13	to	to	TO
cord-314013-g091lv0s	42	14	be	be	VB
cord-314013-g091lv0s	42	15	a	a	DT
cord-314013-g091lv0s	42	16	rational	rational	JJ
cord-314013-g091lv0s	42	17	therapeutic	therapeutic	JJ
cord-314013-g091lv0s	42	18	approach	approach	NN
cord-314013-g091lv0s	42	19	to	to	IN
cord-314013-g091lv0s	42	20	contrast	contrast	VB
cord-314013-g091lv0s	42	21	CRS	CRS	NNP
cord-314013-g091lv0s	42	22	associated	associate	VBN
cord-314013-g091lv0s	42	23	with	with	IN
cord-314013-g091lv0s	42	24	COVID-19	COVID-19	NNP
cord-314013-g091lv0s	42	25	.	.	.
cord-314013-g091lv0s	43	1	TCZ	TCZ	NNP
cord-314013-g091lv0s	43	2	,	,	,
cord-314013-g091lv0s	43	3	a	a	DT
cord-314013-g091lv0s	43	4	first	first	JJ
cord-314013-g091lv0s	43	5	-	-	HYPH
cord-314013-g091lv0s	43	6	line	line	NN
cord-314013-g091lv0s	43	7	drug	drug	NN
cord-314013-g091lv0s	43	8	in	in	IN
cord-314013-g091lv0s	43	9	specific	specific	JJ
cord-314013-g091lv0s	43	10	pathologies	pathology	NNS
cord-314013-g091lv0s	43	11	,	,	,
cord-314013-g091lv0s	43	12	proved	prove	VBD
cord-314013-g091lv0s	43	13	to	to	TO
cord-314013-g091lv0s	43	14	be	be	VB
cord-314013-g091lv0s	43	15	effective	effective	JJ
cord-314013-g091lv0s	43	16	and	and	CC
cord-314013-g091lv0s	43	17	particularly	particularly	RB
cord-314013-g091lv0s	43	18	safe	safe	JJ
cord-314013-g091lv0s	43	19	for	for	IN
cord-314013-g091lv0s	43	20	acute	acute	JJ
cord-314013-g091lv0s	43	21	treatment	treatment	NN
cord-314013-g091lv0s	43	22	as	as	IN
cord-314013-g091lv0s	43	23	would	would	MD
cord-314013-g091lv0s	43	24	required	require	VBN
cord-314013-g091lv0s	43	25	for	for	IN
cord-314013-g091lv0s	43	26	blocking	block	VBG
cord-314013-g091lv0s	43	27	IL-6	IL-6	NNP
cord-314013-g091lv0s	43	28	in	in	IN
cord-314013-g091lv0s	43	29	COVID-19	COVID-19	NNP
cord-314013-g091lv0s	43	30	.	.	.
cord-314013-g091lv0s	44	1	The	the	DT
cord-314013-g091lv0s	44	2	efficacy	efficacy	NN
cord-314013-g091lv0s	44	3	of	of	IN
cord-314013-g091lv0s	44	4	blocking	block	VBG
cord-314013-g091lv0s	44	5	IL-6	IL-6	NNP
cord-314013-g091lv0s	44	6	signaling	signal	VBG
cord-314013-g091lv0s	44	7	in	in	IN
cord-314013-g091lv0s	44	8	COVID-19	COVID-19	NNP
cord-314013-g091lv0s	44	9	is	be	VBZ
cord-314013-g091lv0s	44	10	currently	currently	RB
cord-314013-g091lv0s	44	11	under	under	IN
cord-314013-g091lv0s	44	12	investigation	investigation	NN
cord-314013-g091lv0s	44	13	,	,	,
cord-314013-g091lv0s	44	14	with	with	IN
cord-314013-g091lv0s	44	15	still	still	RB
cord-314013-g091lv0s	44	16	unexplored	unexplored	JJ
cord-314013-g091lv0s	44	17	backstage	backstage	NN
cord-314013-g091lv0s	44	18	.	.	.
cord-314013-g091lv0s	45	1	The	the	DT
cord-314013-g091lv0s	45	2	use	use	NN
cord-314013-g091lv0s	45	3	of	of	IN
cord-314013-g091lv0s	45	4	TCZ	tcz	NN
cord-314013-g091lv0s	45	5	in	in	IN
cord-314013-g091lv0s	45	6	the	the	DT
cord-314013-g091lv0s	45	7	treatment	treatment	NN
cord-314013-g091lv0s	45	8	of	of	IN
cord-314013-g091lv0s	45	9	COVID-19	COVID-19	NNP
cord-314013-g091lv0s	45	10	pneumonia	pneumonia	NN
cord-314013-g091lv0s	45	11	finds	find	VBZ
cord-314013-g091lv0s	45	12	a	a	DT
cord-314013-g091lv0s	45	13	sound	sound	JJ
cord-314013-g091lv0s	45	14	rational	rational	JJ
cord-314013-g091lv0s	45	15	basis	basis	NN
cord-314013-g091lv0s	45	16	in	in	IN
cord-314013-g091lv0s	45	17	the	the	DT
cord-314013-g091lv0s	45	18	inhibition	inhibition	NN
cord-314013-g091lv0s	45	19	of	of	IN
cord-314013-g091lv0s	45	20	virus	virus	NN
cord-314013-g091lv0s	45	21	-	-	HYPH
cord-314013-g091lv0s	45	22	triggered	trigger	VBN
cord-314013-g091lv0s	45	23	excessive	excessive	JJ
cord-314013-g091lv0s	45	24	and	and	CC
cord-314013-g091lv0s	45	25	aberrant	aberrant	JJ
cord-314013-g091lv0s	45	26	inflammatory	inflammatory	JJ
cord-314013-g091lv0s	45	27	responses	response	NNS
cord-314013-g091lv0s	45	28	,	,	,
cord-314013-g091lv0s	45	29	leading	lead	VBG
cord-314013-g091lv0s	45	30	to	to	IN
cord-314013-g091lv0s	45	31	fibrosis	fibrosis	NN
cord-314013-g091lv0s	45	32	and	and	CC
cord-314013-g091lv0s	45	33	lung	lung	NN
cord-314013-g091lv0s	45	34	damage	damage	NN
cord-314013-g091lv0s	45	35	.	.	.
cord-314013-g091lv0s	46	1	However	however	RB
cord-314013-g091lv0s	46	2	,	,	,
cord-314013-g091lv0s	46	3	IL-6	IL-6	NNP
cord-314013-g091lv0s	46	4	neutralization	neutralization	NN
cord-314013-g091lv0s	46	5	might	may	MD
cord-314013-g091lv0s	46	6	lead	lead	VB
cord-314013-g091lv0s	46	7	to	to	IN
cord-314013-g091lv0s	46	8	a	a	DT
cord-314013-g091lv0s	46	9	variety	variety	NN
cord-314013-g091lv0s	46	10	of	of	IN
cord-314013-g091lv0s	46	11	immunomodulatory	immunomodulatory	JJ
cord-314013-g091lv0s	46	12	mechanisms	mechanism	NNS
cord-314013-g091lv0s	46	13	potentially	potentially	RB
cord-314013-g091lv0s	46	14	contributing	contribute	VBG
cord-314013-g091lv0s	46	15	to	to	IN
cord-314013-g091lv0s	46	16	its	-PRON-	PRP$
cord-314013-g091lv0s	46	17	therapeutic	therapeutic	JJ
cord-314013-g091lv0s	46	18	activity	activity	NN
cord-314013-g091lv0s	46	19	in	in	IN
cord-314013-g091lv0s	46	20	COVID-19	COVID-19	NNP
cord-314013-g091lv0s	46	21	treatment	treatment	NN
cord-314013-g091lv0s	46	22	.	.	.
cord-314013-g091lv0s	47	1	A	a	DT
cord-314013-g091lv0s	47	2	powerful	powerful	JJ
cord-314013-g091lv0s	47	3	immunomodulatory	immunomodulatory	JJ
cord-314013-g091lv0s	47	4	pathway	pathway	NN
cord-314013-g091lv0s	47	5	opposing	oppose	VBG
cord-314013-g091lv0s	47	6	hyperinflammatory	hyperinflammatory	NNP
cord-314013-g091lv0s	47	7	responses	response	NNS
cord-314013-g091lv0s	47	8	is	be	VBZ
cord-314013-g091lv0s	47	9	represented	represent	VBN
cord-314013-g091lv0s	47	10	by	by	IN
cord-314013-g091lv0s	47	11	Trp	Trp	NNP
cord-314013-g091lv0s	47	12	catabolism	catabolism	NN
cord-314013-g091lv0s	47	13	,	,	,
cord-314013-g091lv0s	47	14	which	which	WDT
cord-314013-g091lv0s	47	15	generates	generate	VBZ
cord-314013-g091lv0s	47	16	a	a	DT
cord-314013-g091lv0s	47	17	plethora	plethora	NN
cord-314013-g091lv0s	47	18	of	of	IN
cord-314013-g091lv0s	47	19	immunoactive	immunoactive	JJ
cord-314013-g091lv0s	47	20	metabolites	metabolite	NNS
cord-314013-g091lv0s	47	21	,	,	,
cord-314013-g091lv0s	47	22	collectively	collectively	RB
cord-314013-g091lv0s	47	23	known	know	VBN
cord-314013-g091lv0s	47	24	as	as	IN
cord-314013-g091lv0s	47	25	kynurenines	kynurenines	NNP
cord-314013-g091lv0s	47	26	(	(	-LRB-
cord-314013-g091lv0s	47	27	Grohmann	Grohmann	NNP
cord-314013-g091lv0s	47	28	et	et	NNP
cord-314013-g091lv0s	47	29	al	al	NNP
cord-314013-g091lv0s	47	30	.	.	NNP
cord-314013-g091lv0s	47	31	,	,	,
cord-314013-g091lv0s	47	32	2017	2017	CD
cord-314013-g091lv0s	47	33	)	)	-RRB-
cord-314013-g091lv0s	47	34	.	.	.
cord-314013-g091lv0s	48	1	In	in	IN
cord-314013-g091lv0s	48	2	immune	immune	JJ
cord-314013-g091lv0s	48	3	cells	cell	NNS
cord-314013-g091lv0s	48	4	,	,	,
cord-314013-g091lv0s	48	5	the	the	DT
cord-314013-g091lv0s	48	6	conversion	conversion	NN
cord-314013-g091lv0s	48	7	of	of	IN
cord-314013-g091lv0s	48	8	Trp	Trp	NNP
cord-314013-g091lv0s	48	9	into	into	IN
cord-314013-g091lv0s	48	10	L	l	NN
cord-314013-g091lv0s	48	11	-	-	HYPH
cord-314013-g091lv0s	48	12	kynurenine	kynurenine	JJ
cord-314013-g091lv0s	48	13	(	(	-LRB-
cord-314013-g091lv0s	48	14	Kyn	Kyn	NNP
cord-314013-g091lv0s	48	15	;	;	:
cord-314013-g091lv0s	48	16	a	a	DT
cord-314013-g091lv0s	48	17	non	non	JJ
cord-314013-g091lv0s	48	18	-	-	JJ
cord-314013-g091lv0s	48	19	proteogenic	proteogenic	JJ
cord-314013-g091lv0s	48	20	amino	amino	NN
cord-314013-g091lv0s	48	21	acid	acid	NN
cord-314013-g091lv0s	48	22	)	)	-RRB-
cord-314013-g091lv0s	48	23	is	be	VBZ
cord-314013-g091lv0s	48	24	finely	finely	RB
cord-314013-g091lv0s	48	25	controlled	control	VBN
cord-314013-g091lv0s	48	26	by	by	IN
cord-314013-g091lv0s	48	27	the	the	DT
cord-314013-g091lv0s	48	28	enzyme	enzyme	NN
cord-314013-g091lv0s	48	29	indoleamine	indoleamine	NN
cord-314013-g091lv0s	48	30	2,3	2,3	CD
cord-314013-g091lv0s	48	31	dioxygenase	dioxygenase	NN
cord-314013-g091lv0s	48	32	1	1	CD
cord-314013-g091lv0s	48	33	(	(	-LRB-
cord-314013-g091lv0s	48	34	IDO1	IDO1	NNP
cord-314013-g091lv0s	48	35	)	)	-RRB-
cord-314013-g091lv0s	48	36	.	.	.
cord-314013-g091lv0s	49	1	A	a	DT
cord-314013-g091lv0s	49	2	tight	tight	JJ
cord-314013-g091lv0s	49	3	correlation	correlation	NN
cord-314013-g091lv0s	49	4	has	have	VBZ
cord-314013-g091lv0s	49	5	been	be	VBN
cord-314013-g091lv0s	49	6	demonstrated	demonstrate	VBN
cord-314013-g091lv0s	49	7	between	between	IN
cord-314013-g091lv0s	49	8	IL-6driven	il-6driven	DT
cord-314013-g091lv0s	49	9	inflammation	inflammation	NN
cord-314013-g091lv0s	49	10	and	and	CC
cord-314013-g091lv0s	49	11	the	the	DT
cord-314013-g091lv0s	49	12	defective	defective	JJ
cord-314013-g091lv0s	49	13	activity	activity	NN
cord-314013-g091lv0s	49	14	of	of	IN
cord-314013-g091lv0s	49	15	IDO1	IDO1	NNP
cord-314013-g091lv0s	49	16	,	,	,
cord-314013-g091lv0s	49	17	compromising	compromise	VBG
cord-314013-g091lv0s	49	18	its	-PRON-	PRP$
cord-314013-g091lv0s	49	19	role	role	NN
cord-314013-g091lv0s	49	20	of	of	IN
cord-314013-g091lv0s	49	21	immune	immune	JJ
cord-314013-g091lv0s	49	22	homeostasis	homeostasis	NN
cord-314013-g091lv0s	49	23	regulator	regulator	NN
cord-314013-g091lv0s	50	1	(	(	-LRB-
cord-314013-g091lv0s	50	2	Orabona	Orabona	NNP
cord-314013-g091lv0s	50	3	et	et	NNP
cord-314013-g091lv0s	50	4	al	al	NNP
cord-314013-g091lv0s	50	5	.	.	NNP
cord-314013-g091lv0s	50	6	,	,	,
cord-314013-g091lv0s	50	7	2012	2012	CD
cord-314013-g091lv0s	50	8	)	)	-RRB-
cord-314013-g091lv0s	50	9	.	.	.
cord-314013-g091lv0s	51	1	IDO1	ido1	JJ
cord-314013-g091lv0s	51	2	defect	defect	NN
cord-314013-g091lv0s	51	3	-	-	:
cord-314013-g091lv0s	51	4	and	and	CC
cord-314013-g091lv0s	51	5	thus	thus	RB
cord-314013-g091lv0s	51	6	the	the	DT
cord-314013-g091lv0s	51	7	impaired	impaired	JJ
cord-314013-g091lv0s	51	8	generation	generation	NN
cord-314013-g091lv0s	51	9	of	of	IN
cord-314013-g091lv0s	51	10	immunoregulatory	immunoregulatory	NNP
cord-314013-g091lv0s	51	11	Kynis	Kynis	NNP
cord-314013-g091lv0s	51	12	caused	cause	VBN
cord-314013-g091lv0s	51	13	by	by	IN
cord-314013-g091lv0s	51	14	the	the	DT
cord-314013-g091lv0s	51	15	ubiquitin	ubiquitin	NN
cord-314013-g091lv0s	51	16	-	-	HYPH
cord-314013-g091lv0s	51	17	proteasome	proteasome	VBN
cord-314013-g091lv0s	51	18	system	system	NN
cord-314013-g091lv0s	51	19	-	-	HYPH
cord-314013-g091lv0s	51	20	mediated	mediate	VBN
cord-314013-g091lv0s	51	21	proteolysis	proteolysis	NN
cord-314013-g091lv0s	51	22	of	of	IN
cord-314013-g091lv0s	51	23	IDO1	IDO1	NNP
cord-314013-g091lv0s	51	24	protein	protein	NN
cord-314013-g091lv0s	51	25	induced	induce	VBN
cord-314013-g091lv0s	51	26	by	by	IN
cord-314013-g091lv0s	52	1	IL-6	IL-6	NNP
cord-314013-g091lv0s	52	2	(	(	-LRB-
cord-314013-g091lv0s	52	3	Orabona	Orabona	NNP
cord-314013-g091lv0s	52	4	et	et	NNP
cord-314013-g091lv0s	52	5	al	al	NNP
cord-314013-g091lv0s	52	6	.	.	NNP
cord-314013-g091lv0s	52	7	,	,	,
cord-314013-g091lv0s	52	8	2008	2008	CD
cord-314013-g091lv0s	52	9	)	)	-RRB-
cord-314013-g091lv0s	52	10	.	.	.
cord-314013-g091lv0s	53	1	Both	both	DT
cord-314013-g091lv0s	53	2	murine	murine	JJ
cord-314013-g091lv0s	53	3	dendritic	dendritic	JJ
cord-314013-g091lv0s	53	4	cells	cell	NNS
cord-314013-g091lv0s	53	5	(	(	-LRB-
cord-314013-g091lv0s	53	6	DCs	DCs	NNP
cord-314013-g091lv0s	53	7	)	)	-RRB-
cord-314013-g091lv0s	53	8	and	and	CC
cord-314013-g091lv0s	53	9	human	human	JJ
cord-314013-g091lv0s	53	10	peripheral	peripheral	JJ
cord-314013-g091lv0s	53	11	blood	blood	NN
cord-314013-g091lv0s	53	12	mononuclear	mononuclear	NN
cord-314013-g091lv0s	53	13	cells	cell	NNS
cord-314013-g091lv0s	53	14	(	(	-LRB-
cord-314013-g091lv0s	53	15	PBMCs	pbmc	NNS
cord-314013-g091lv0s	53	16	)	)	-RRB-
cord-314013-g091lv0s	53	17	,	,	,
cord-314013-g091lv0s	53	18	readily	readily	RB
cord-314013-g091lv0s	53	19	responding	respond	VBG
cord-314013-g091lv0s	53	20	to	to	IN
cord-314013-g091lv0s	53	21	inflammatory	inflammatory	JJ
cord-314013-g091lv0s	53	22	stimuli	stimulus	NNS
cord-314013-g091lv0s	53	23	,	,	,
cord-314013-g091lv0s	53	24	can	can	MD
cord-314013-g091lv0s	53	25	activate	activate	VB
cord-314013-g091lv0s	53	26	such	such	PDT
cord-314013-g091lv0s	53	27	a	a	DT
cord-314013-g091lv0s	53	28	mechanism	mechanism	NN
cord-314013-g091lv0s	53	29	of	of	IN
cord-314013-g091lv0s	53	30	IDO1	IDO1	NNP
cord-314013-g091lv0s	53	31	turnover	turnover	NN
cord-314013-g091lv0s	53	32	for	for	IN
cord-314013-g091lv0s	53	33	repressing	repress	VBG
cord-314013-g091lv0s	53	34	its	-PRON-	PRP$
cord-314013-g091lv0s	53	35	immunomodulatory	immunomodulatory	JJ
cord-314013-g091lv0s	53	36	activity	activity	NN
cord-314013-g091lv0s	53	37	and	and	CC
cord-314013-g091lv0s	53	38	thus	thus	RB
cord-314013-g091lv0s	53	39	express	express	VB
cord-314013-g091lv0s	53	40	a	a	DT
cord-314013-g091lv0s	53	41	ready	ready	JJ
cord-314013-g091lv0s	53	42	-	-	HYPH
cord-314013-g091lv0s	53	43	to	to	TO
cord-314013-g091lv0s	53	44	-	-	HYPH
cord-314013-g091lv0s	53	45	start	start	VB
cord-314013-g091lv0s	53	46	immunogenic	immunogenic	JJ
cord-314013-g091lv0s	53	47	phenotype	phenotype	NN
cord-314013-g091lv0s	53	48	.	.	.
cord-314013-g091lv0s	54	1	In	in	IN
cord-314013-g091lv0s	54	2	hyperinflammatory	hyperinflammatory	JJ
cord-314013-g091lv0s	54	3	conditions	condition	NNS
cord-314013-g091lv0s	54	4	,	,	,
cord-314013-g091lv0s	54	5	aberrant	aberrant	JJ
cord-314013-g091lv0s	54	6	secretion	secretion	NN
cord-314013-g091lv0s	54	7	of	of	IN
cord-314013-g091lv0s	54	8	IL-6	IL-6	NNP
cord-314013-g091lv0s	54	9	,	,	,
cord-314013-g091lv0s	54	10	as	as	IN
cord-314013-g091lv0s	54	11	a	a	DT
cord-314013-g091lv0s	54	12	triggering	trigger	VBG
cord-314013-g091lv0s	54	13	mechanism	mechanism	NN
cord-314013-g091lv0s	54	14	of	of	IN
cord-314013-g091lv0s	54	15	IDO1	IDO1	NNP
cord-314013-g091lv0s	54	16	proteolysis	proteolysis	NN
cord-314013-g091lv0s	54	17	,	,	,
cord-314013-g091lv0s	54	18	leads	lead	VBZ
cord-314013-g091lv0s	54	19	to	to	IN
cord-314013-g091lv0s	54	20	accelerated	accelerate	VBN
cord-314013-g091lv0s	54	21	IDO1	IDO1	NNP
cord-314013-g091lv0s	54	22	proteolysis	proteolysis	NN
cord-314013-g091lv0s	54	23	and	and	CC
cord-314013-g091lv0s	54	24	to	to	IN
cord-314013-g091lv0s	54	25	the	the	DT
cord-314013-g091lv0s	54	26	knocking	knock	VBG
cord-314013-g091lv0s	54	27	down	down	RP
cord-314013-g091lv0s	54	28	of	of	IN
cord-314013-g091lv0s	54	29	a	a	DT
cord-314013-g091lv0s	54	30	potent	potent	JJ
cord-314013-g091lv0s	54	31	immunoregulatory	immunoregulatory	JJ
cord-314013-g091lv0s	54	32	mechanism	mechanism	NN
cord-314013-g091lv0s	54	33	.	.	.
cord-314013-g091lv0s	55	1	In	in	IN
cord-314013-g091lv0s	55	2	COVID-19-associated	COVID-19-associated	NNP
cord-314013-g091lv0s	55	3	CRS	CRS	NNP
cord-314013-g091lv0s	55	4	,	,	,
cord-314013-g091lv0s	55	5	the	the	DT
cord-314013-g091lv0s	55	6	immunoregulatory	immunoregulatory	JJ
cord-314013-g091lv0s	55	7	Trp	trp	NN
cord-314013-g091lv0s	55	8	-	-	HYPH
cord-314013-g091lv0s	55	9	derived	derive	VBN
cord-314013-g091lv0s	55	10	metabolites	metabolite	NNS
cord-314013-g091lv0s	55	11	generated	generate	VBN
cord-314013-g091lv0s	55	12	by	by	IN
cord-314013-g091lv0s	55	13	IDO1	IDO1	NNP
cord-314013-g091lv0s	55	14	could	could	MD
cord-314013-g091lv0s	55	15	be	be	VB
cord-314013-g091lv0s	55	16	deficient	deficient	JJ
cord-314013-g091lv0s	55	17	and	and	CC
cord-314013-g091lv0s	55	18	their	-PRON-	PRP$
cord-314013-g091lv0s	55	19	absence	absence	NN
cord-314013-g091lv0s	55	20	could	could	MD
cord-314013-g091lv0s	55	21	worsen	worsen	VB
cord-314013-g091lv0s	55	22	the	the	DT
cord-314013-g091lv0s	55	23	inflammatory	inflammatory	JJ
cord-314013-g091lv0s	55	24	events	event	NNS
cord-314013-g091lv0s	55	25	in	in	IN
cord-314013-g091lv0s	55	26	COVID-19	COVID-19	NNP
cord-314013-g091lv0s	55	27	.	.	.
cord-314013-g091lv0s	56	1	IL-6-mediated	il-6-mediate	VBN
cord-314013-g091lv0s	57	1	IDO1	ido1	JJ
cord-314013-g091lv0s	57	2	proteolysis	proteolysis	NN
cord-314013-g091lv0s	57	3	has	have	VBZ
cord-314013-g091lv0s	57	4	been	be	VBN
cord-314013-g091lv0s	57	5	previously	previously	RB
cord-314013-g091lv0s	57	6	reported	report	VBN
cord-314013-g091lv0s	57	7	as	as	IN
cord-314013-g091lv0s	57	8	a	a	DT
cord-314013-g091lv0s	57	9	pathogenic	pathogenic	JJ
cord-314013-g091lv0s	57	10	mechanism	mechanism	NN
cord-314013-g091lv0s	57	11	in	in	IN
cord-314013-g091lv0s	57	12	autoimmune	autoimmune	JJ
cord-314013-g091lv0s	57	13	diabetes	diabetes	NN
cord-314013-g091lv0s	57	14	,	,	,
cord-314013-g091lv0s	57	15	where	where	WRB
cord-314013-g091lv0s	57	16	it	-PRON-	PRP
cord-314013-g091lv0s	57	17	contributes	contribute	VBZ
cord-314013-g091lv0s	57	18	to	to	IN
cord-314013-g091lv0s	57	19	the	the	DT
cord-314013-g091lv0s	57	20	onset	onset	NN
cord-314013-g091lv0s	57	21	of	of	IN
cord-314013-g091lv0s	57	22	the	the	DT
cord-314013-g091lv0s	57	23	autoimmune	autoimmune	JJ
cord-314013-g091lv0s	57	24	response	response	NN
cord-314013-g091lv0s	57	25	against	against	IN
cord-314013-g091lv0s	57	26	pancreatic	pancreatic	JJ
cord-314013-g091lv0s	57	27	autoantigens	autoantigen	NNS
cord-314013-g091lv0s	57	28	.	.	.
cord-314013-g091lv0s	58	1	TCZ	TCZ	NNP
cord-314013-g091lv0s	58	2	was	be	VBD
cord-314013-g091lv0s	58	3	demonstrated	demonstrate	VBN
cord-314013-g091lv0s	58	4	to	to	TO
cord-314013-g091lv0s	58	5	be	be	VB
cord-314013-g091lv0s	58	6	beneficial	beneficial	JJ
cord-314013-g091lv0s	58	7	in	in	IN
cord-314013-g091lv0s	58	8	hyperglycemic	hyperglycemic	JJ
cord-314013-g091lv0s	58	9	NOD	NOD	NNP
cord-314013-g091lv0s	58	10	mice	mouse	NNS
cord-314013-g091lv0s	58	11	in	in	IN
cord-314013-g091lv0s	58	12	an	an	DT
cord-314013-g091lv0s	58	13	IDO1-dependent	IDO1-dependent	NNP
cord-314013-g091lv0s	58	14	manner	manner	NN
cord-314013-g091lv0s	58	15	and	and	CC
cord-314013-g091lv0s	58	16	to	to	TO
cord-314013-g091lv0s	58	17	restore	restore	VB
cord-314013-g091lv0s	58	18	in	in	IN
cord-314013-g091lv0s	59	1	vitro	vitro	FW
cord-314013-g091lv0s	59	2	IDO1	IDO1	NNP
cord-314013-g091lv0s	59	3	activity	activity	NN
cord-314013-g091lv0s	59	4	in	in	IN
cord-314013-g091lv0s	59	5	PBMCs	pbmc	NNS
cord-314013-g091lv0s	59	6	from	from	IN
cord-314013-g091lv0s	59	7	pediatric	pediatric	JJ
cord-314013-g091lv0s	59	8	diabetic	diabetic	JJ
cord-314013-g091lv0s	59	9	patients	patient	NNS
cord-314013-g091lv0s	59	10	(	(	-LRB-
cord-314013-g091lv0s	59	11	Orabona	Orabona	NNP
cord-314013-g091lv0s	59	12	et	et	NNP
cord-314013-g091lv0s	59	13	al	al	NNP
cord-314013-g091lv0s	59	14	.	.	.
cord-314013-g091lv0s	60	1	,	,	,
cord-314013-g091lv0s	60	2	2018	2018	CD
cord-314013-g091lv0s	60	3	)	)	-RRB-
cord-314013-g091lv0s	60	4	,	,	,
cord-314013-g091lv0s	60	5	thus	thus	RB
cord-314013-g091lv0s	60	6	confirming	confirm	VBG
cord-314013-g091lv0s	60	7	the	the	DT
cord-314013-g091lv0s	60	8	relevance	relevance	NN
cord-314013-g091lv0s	60	9	of	of	IN
cord-314013-g091lv0s	60	10	Trp	trp	NN
cord-314013-g091lv0s	60	11	metabolic	metabolic	JJ
cord-314013-g091lv0s	60	12	pathway	pathway	NN
cord-314013-g091lv0s	60	13	in	in	IN
cord-314013-g091lv0s	60	14	the	the	DT
cord-314013-g091lv0s	60	15	control	control	NN
cord-314013-g091lv0s	60	16	of	of	IN
cord-314013-g091lv0s	60	17	inflammation	inflammation	NN
cord-314013-g091lv0s	60	18	and	and	CC
cord-314013-g091lv0s	60	19	the	the	DT
cord-314013-g091lv0s	60	20	close	close	JJ
cord-314013-g091lv0s	60	21	interplay	interplay	NN
cord-314013-g091lv0s	60	22	between	between	IN
cord-314013-g091lv0s	60	23	IL-6	IL-6	NNP
cord-314013-g091lv0s	60	24	and	and	CC
cord-314013-g091lv0s	60	25	IDO1	IDO1	NNP
cord-314013-g091lv0s	60	26	's	's	POS
cord-314013-g091lv0s	60	27	activity	activity	NN
cord-314013-g091lv0s	60	28	.	.	.
cord-314013-g091lv0s	61	1	In	in	IN
cord-314013-g091lv0s	61	2	the	the	DT
cord-314013-g091lv0s	61	3	control	control	NN
cord-314013-g091lv0s	61	4	of	of	IN
cord-314013-g091lv0s	61	5	hyperinflammatory	hyperinflammatory	NNP
cord-314013-g091lv0s	61	6	responses	response	NNS
cord-314013-g091lv0s	61	7	,	,	,
cord-314013-g091lv0s	61	8	Kyn	kyn	NN
cord-314013-g091lv0s	61	9	-	-	:
cord-314013-g091lv0s	61	10	the	the	DT
cord-314013-g091lv0s	61	11	main	main	JJ
cord-314013-g091lv0s	61	12	byproduct	byproduct	NN
cord-314013-g091lv0s	61	13	of	of	IN
cord-314013-g091lv0s	61	14	Trp	trp	NN
cord-314013-g091lv0s	61	15	metabolism	metabolism	NN
cord-314013-g091lv0s	61	16	-	-	HYPH
cord-314013-g091lv0s	61	17	plays	play	VBZ
cord-314013-g091lv0s	61	18	a	a	DT
cord-314013-g091lv0s	61	19	major	major	JJ
cord-314013-g091lv0s	61	20	role	role	NN
cord-314013-g091lv0s	61	21	as	as	IN
cord-314013-g091lv0s	61	22	an	an	DT
cord-314013-g091lv0s	61	23	endogenous	endogenous	JJ
cord-314013-g091lv0s	61	24	agonist	agonist	NN
cord-314013-g091lv0s	61	25	of	of	IN
cord-314013-g091lv0s	61	26	the	the	DT
cord-314013-g091lv0s	61	27	immunoregulatory	immunoregulatory	JJ
cord-314013-g091lv0s	61	28	Aryl	Aryl	NNP
cord-314013-g091lv0s	61	29	hydrocarbon	hydrocarbon	NN
cord-314013-g091lv0s	61	30	Receptor	Receptor	NNP
cord-314013-g091lv0s	61	31	(	(	-LRB-
cord-314013-g091lv0s	61	32	AhR	ahr	NN
cord-314013-g091lv0s	61	33	)	)	-RRB-
cord-314013-g091lv0s	61	34	.	.	.
cord-314013-g091lv0s	62	1	As	as	IN
cord-314013-g091lv0s	62	2	a	a	DT
cord-314013-g091lv0s	62	3	result	result	NN
cord-314013-g091lv0s	62	4	,	,	,
cord-314013-g091lv0s	62	5	a	a	DT
cord-314013-g091lv0s	62	6	feed	feed	VB
cord-314013-g091lv0s	62	7	-	-	HYPH
cord-314013-g091lv0s	62	8	forward	forward	NN
cord-314013-g091lv0s	62	9	loop	loop	NN
cord-314013-g091lv0s	62	10	constraining	constrain	VBG
cord-314013-g091lv0s	62	11	hyperinflammation	hyperinflammation	NN
cord-314013-g091lv0s	62	12	is	be	VBZ
cord-314013-g091lv0s	62	13	established	establish	VBN
cord-314013-g091lv0s	62	14	,	,	,
cord-314013-g091lv0s	62	15	whereby	whereby	WRB
cord-314013-g091lv0s	62	16	IDO1	IDO1	NNP
cord-314013-g091lv0s	62	17	generates	generate	VBZ
cord-314013-g091lv0s	62	18	Kyn	Kyn	NNP
cord-314013-g091lv0s	62	19	,	,	,
cord-314013-g091lv0s	62	20	an	an	DT
cord-314013-g091lv0s	62	21	activating	activate	VBG
cord-314013-g091lv0s	62	22	ligand	ligand	NN
cord-314013-g091lv0s	62	23	for	for	IN
cord-314013-g091lv0s	62	24	AhR	ahr	NN
cord-314013-g091lv0s	62	25	that	that	IN
cord-314013-g091lv0s	62	26	,	,	,
cord-314013-g091lv0s	62	27	in	in	IN
cord-314013-g091lv0s	62	28	turn	turn	NN
cord-314013-g091lv0s	62	29	,	,	,
cord-314013-g091lv0s	62	30	will	will	MD
cord-314013-g091lv0s	62	31	enhance	enhance	VB
cord-314013-g091lv0s	62	32	IDO1	IDO1	NNP
cord-314013-g091lv0s	62	33	expression	expression	NN
cord-314013-g091lv0s	62	34	in	in	IN
cord-314013-g091lv0s	62	35	DCs	DCs	NNP
cord-314013-g091lv0s	62	36	(	(	-LRB-
cord-314013-g091lv0s	62	37	Manni	Manni	NNP
cord-314013-g091lv0s	62	38	et	et	NNP
cord-314013-g091lv0s	62	39	al	al	NNP
cord-314013-g091lv0s	62	40	.	.	NNP
cord-314013-g091lv0s	62	41	,	,	,
cord-314013-g091lv0s	62	42	2020	2020	CD
cord-314013-g091lv0s	62	43	)	)	-RRB-
cord-314013-g091lv0s	62	44	.	.	.
cord-314013-g091lv0s	63	1	Such	such	PDT
cord-314013-g091lv0s	63	2	a	a	DT
cord-314013-g091lv0s	63	3	positive	positive	JJ
cord-314013-g091lv0s	63	4	feedforward	feedforward	NN
cord-314013-g091lv0s	63	5	loop	loop	NN
cord-314013-g091lv0s	63	6	contributes	contribute	VBZ
cord-314013-g091lv0s	63	7	to	to	IN
cord-314013-g091lv0s	63	8	a	a	DT
cord-314013-g091lv0s	63	9	state	state	NN
cord-314013-g091lv0s	63	10	of	of	IN
cord-314013-g091lv0s	63	11	endotoxin	endotoxin	NN
cord-314013-g091lv0s	63	12	tolerance	tolerance	NN
cord-314013-g091lv0s	63	13	,	,	,
cord-314013-g091lv0s	63	14	protecting	protect	VBG
cord-314013-g091lv0s	63	15	mice	mouse	NNS
cord-314013-g091lv0s	63	16	against	against	IN
cord-314013-g091lv0s	63	17	further	further	JJ
cord-314013-g091lv0s	63	18	bacterial	bacterial	JJ
cord-314013-g091lv0s	63	19	LPS	LPS	NNP
cord-314013-g091lv0s	63	20	challenge	challenge	NN
cord-314013-g091lv0s	63	21	after	after	IN
cord-314013-g091lv0s	63	22	a	a	DT
cord-314013-g091lv0s	63	23	first	first	JJ
cord-314013-g091lv0s	63	24	exposure	exposure	NN
cord-314013-g091lv0s	63	25	to	to	IN
cord-314013-g091lv0s	63	26	LPS	LPS	NNP
cord-314013-g091lv0s	63	27	(	(	-LRB-
cord-314013-g091lv0s	63	28	Bessede	Bessede	NNP
cord-314013-g091lv0s	63	29	et	et	NNP
cord-314013-g091lv0s	63	30	al	al	NNP
cord-314013-g091lv0s	63	31	.	.	NNP
cord-314013-g091lv0s	63	32	,	,	,
cord-314013-g091lv0s	63	33	2014	2014	CD
cord-314013-g091lv0s	63	34	)	)	-RRB-
cord-314013-g091lv0s	63	35	.	.	.
cord-314013-g091lv0s	64	1	Notably	notably	RB
cord-314013-g091lv0s	64	2	,	,	,
cord-314013-g091lv0s	64	3	AhR	AhR	NNP
cord-314013-g091lv0s	64	4	is	be	VBZ
cord-314013-g091lv0s	64	5	widely	widely	RB
cord-314013-g091lv0s	64	6	expressed	express	VBN
cord-314013-g091lv0s	64	7	in	in	IN
cord-314013-g091lv0s	64	8	immune	immune	JJ
cord-314013-g091lv0s	64	9	cells	cell	NNS
cord-314013-g091lv0s	64	10	where	where	WRB
cord-314013-g091lv0s	64	11	the	the	DT
cord-314013-g091lv0s	64	12	activated	activate	VBN
cord-314013-g091lv0s	64	13	receptor	receptor	NN
cord-314013-g091lv0s	64	14	can	can	MD
cord-314013-g091lv0s	64	15	tip	tip	VB
cord-314013-g091lv0s	64	16	the	the	DT
cord-314013-g091lv0s	64	17	balance	balance	NN
cord-314013-g091lv0s	64	18	regulatory	regulatory	JJ
cord-314013-g091lv0s	64	19	and	and	CC
cord-314013-g091lv0s	64	20	inflammatory	inflammatory	JJ
cord-314013-g091lv0s	64	21	T	t	NN
cord-314013-g091lv0s	64	22	cells	cell	NNS
cord-314013-g091lv0s	64	23	in	in	IN
cord-314013-g091lv0s	64	24	favor	favor	NN
cord-314013-g091lv0s	64	25	of	of	IN
cord-314013-g091lv0s	64	26	the	the	DT
cord-314013-g091lv0s	64	27	former	former	JJ
cord-314013-g091lv0s	64	28	subset	subset	NN
cord-314013-g091lv0s	64	29	.	.	.
cord-314013-g091lv0s	65	1	Administration	Administration	NNP
cord-314013-g091lv0s	65	2	of	of	IN
cord-314013-g091lv0s	65	3	AhR	AhR	NNP
cord-314013-g091lv0s	65	4	agonists	agonist	NNS
cord-314013-g091lv0s	65	5	alleviated	alleviate	VBD
cord-314013-g091lv0s	65	6	immunopathology	immunopathology	NN
cord-314013-g091lv0s	65	7	in	in	IN
cord-314013-g091lv0s	65	8	various	various	JJ
cord-314013-g091lv0s	65	9	animal	animal	NN
cord-314013-g091lv0s	65	10	models	model	NNS
cord-314013-g091lv0s	65	11	,	,	,
cord-314013-g091lv0s	65	12	such	such	JJ
cord-314013-g091lv0s	65	13	as	as	IN
cord-314013-g091lv0s	65	14	experimental	experimental	JJ
cord-314013-g091lv0s	65	15	autoimmune	autoimmune	JJ
cord-314013-g091lv0s	65	16	encephalomyelitis	encephalomyelitis	NN
cord-314013-g091lv0s	65	17	,	,	,
cord-314013-g091lv0s	65	18	experimental	experimental	JJ
cord-314013-g091lv0s	65	19	colitis	colitis	NN
cord-314013-g091lv0s	65	20	(	(	-LRB-
cord-314013-g091lv0s	65	21	Quintana	Quintana	NNP
cord-314013-g091lv0s	65	22	et	et	NNP
cord-314013-g091lv0s	65	23	al	al	NNP
cord-314013-g091lv0s	65	24	.	.	NNP
cord-314013-g091lv0s	65	25	,	,	,
cord-314013-g091lv0s	65	26	2008	2008	CD
cord-314013-g091lv0s	65	27	)	)	-RRB-
cord-314013-g091lv0s	65	28	and	and	CC
cord-314013-g091lv0s	65	29	,	,	,
cord-314013-g091lv0s	65	30	recently	recently	RB
cord-314013-g091lv0s	65	31	,	,	,
cord-314013-g091lv0s	65	32	a	a	DT
cord-314013-g091lv0s	65	33	model	model	NN
cord-314013-g091lv0s	65	34	of	of	IN
cord-314013-g091lv0s	65	35	pulmonary	pulmonary	JJ
cord-314013-g091lv0s	65	36	fibrosis	fibrosis	NN
cord-314013-g091lv0s	65	37	(	(	-LRB-
cord-314013-g091lv0s	65	38	Takei	Takei	NNP
cord-314013-g091lv0s	65	39	et	et	NNP
cord-314013-g091lv0s	65	40	al	al	NNP
cord-314013-g091lv0s	65	41	.	.	NNP
cord-314013-g091lv0s	65	42	,	,	,
cord-314013-g091lv0s	65	43	2020	2020	CD
cord-314013-g091lv0s	65	44	)	)	-RRB-
cord-314013-g091lv0s	65	45	.	.	.
cord-314013-g091lv0s	66	1	Kyn	Kyn	NNP
cord-314013-g091lv0s	66	2	is	be	VBZ
cord-314013-g091lv0s	66	3	also	also	RB
cord-314013-g091lv0s	66	4	a	a	DT
cord-314013-g091lv0s	66	5	potent	potent	JJ
cord-314013-g091lv0s	66	6	vasodilator	vasodilator	NN
cord-314013-g091lv0s	66	7	of	of	IN
cord-314013-g091lv0s	66	8	systemic	systemic	JJ
cord-314013-g091lv0s	66	9	arteries	artery	NNS
cord-314013-g091lv0s	66	10	and	and	CC
cord-314013-g091lv0s	66	11	has	have	VBZ
cord-314013-g091lv0s	66	12	been	be	VBN
cord-314013-g091lv0s	66	13	found	find	VBN
cord-314013-g091lv0s	66	14	to	to	TO
cord-314013-g091lv0s	66	15	be	be	VB
cord-314013-g091lv0s	66	16	significantly	significantly	RB
cord-314013-g091lv0s	66	17	increased	increase	VBN
cord-314013-g091lv0s	66	18	in	in	IN
cord-314013-g091lv0s	66	19	pulmonary	pulmonary	JJ
cord-314013-g091lv0s	66	20	arterial	arterial	JJ
cord-314013-g091lv0s	66	21	hypertension	hypertension	NN
cord-314013-g091lv0s	66	22	patients	patient	NNS
cord-314013-g091lv0s	66	23	.	.	.
cord-314013-g091lv0s	67	1	In	in	IN
cord-314013-g091lv0s	67	2	chronic	chronic	JJ
cord-314013-g091lv0s	67	3	models	model	NNS
cord-314013-g091lv0s	67	4	of	of	IN
cord-314013-g091lv0s	67	5	pulmonary	pulmonary	JJ
cord-314013-g091lv0s	67	6	arterial	arterial	JJ
cord-314013-g091lv0s	67	7	hypertension	hypertension	NN
cord-314013-g091lv0s	67	8	,	,	,
cord-314013-g091lv0s	67	9	Kyn	Kyn	NNP
cord-314013-g091lv0s	67	10	exerted	exert	VBD
cord-314013-g091lv0s	67	11	acute	acute	JJ
cord-314013-g091lv0s	67	12	pulmonary	pulmonary	JJ
cord-314013-g091lv0s	67	13	vasodilatation	vasodilatation	NN
cord-314013-g091lv0s	67	14	in	in	IN
cord-314013-g091lv0s	67	15	synergy	synergy	NN
cord-314013-g091lv0s	67	16	with	with	IN
cord-314013-g091lv0s	67	17	nitric	nitric	NN
cord-314013-g091lv0s	67	18	oxide	oxide	NN
cord-314013-g091lv0s	68	1	(	(	-LRB-
cord-314013-g091lv0s	68	2	Nagy	Nagy	NNP
cord-314013-g091lv0s	68	3	et	et	NNP
cord-314013-g091lv0s	68	4	al	al	NNP
cord-314013-g091lv0s	68	5	.	.	NNP
cord-314013-g091lv0s	68	6	,	,	,
cord-314013-g091lv0s	68	7	2017	2017	CD
cord-314013-g091lv0s	68	8	)	)	-RRB-
cord-314013-g091lv0s	68	9	.	.	.
cord-314013-g091lv0s	69	1	Overall	overall	RB
cord-314013-g091lv0s	69	2	,	,	,
cord-314013-g091lv0s	69	3	the	the	DT
cord-314013-g091lv0s	69	4	symptomatic	symptomatic	JJ
cord-314013-g091lv0s	69	5	approach	approach	NN
cord-314013-g091lv0s	69	6	using	use	VBG
cord-314013-g091lv0s	69	7	TCZ	TCZ	NNP
cord-314013-g091lv0s	69	8	in	in	IN
cord-314013-g091lv0s	69	9	COVID-19	COVID-19	NNP
cord-314013-g091lv0s	69	10	pneumonia	pneumonia	NN
cord-314013-g091lv0s	69	11	might	may	MD
cord-314013-g091lv0s	69	12	involve	involve	VB
cord-314013-g091lv0s	69	13	still	still	RB
cord-314013-g091lv0s	69	14	uncovered	uncover	VBN
cord-314013-g091lv0s	69	15	beneficial	beneficial	JJ
cord-314013-g091lv0s	69	16	effects	effect	NNS
cord-314013-g091lv0s	69	17	due	due	JJ
cord-314013-g091lv0s	69	18	to	to	IN
cord-314013-g091lv0s	69	19	synergistic	synergistic	JJ
cord-314013-g091lv0s	69	20	,	,	,
cord-314013-g091lv0s	69	21	yet	yet	CC
cord-314013-g091lv0s	69	22	distinct	distinct	JJ
cord-314013-g091lv0s	69	23	,	,	,
cord-314013-g091lv0s	69	24	mechanisms	mechanism	NNS
cord-314013-g091lv0s	69	25	downstream	downstream	RB
cord-314013-g091lv0s	69	26	of	of	IN
cord-314013-g091lv0s	69	27	IL-6	IL-6	NNP
cord-314013-g091lv0s	69	28	signaling	signal	VBG
cord-314013-g091lv0s	70	1	(	(	-LRB-
cord-314013-g091lv0s	70	2	Figure	figure	NN
cord-314013-g091lv0s	70	3	1	1	CD
cord-314013-g091lv0s	70	4	)	)	-RRB-
cord-314013-g091lv0s	70	5	.	.	.
cord-314013-g091lv0s	71	1	Among	among	IN
cord-314013-g091lv0s	71	2	those	those	DT
cord-314013-g091lv0s	71	3	,	,	,
cord-314013-g091lv0s	71	4	the	the	DT
cord-314013-g091lv0s	71	5	restoration	restoration	NN
cord-314013-g091lv0s	71	6	of	of	IN
cord-314013-g091lv0s	71	7	an	an	DT
cord-314013-g091lv0s	71	8	active	active	JJ
cord-314013-g091lv0s	71	9	Trp	trp	NN
cord-314013-g091lv0s	71	10	catabolism	catabolism	NN
cord-314013-g091lv0s	71	11	,	,	,
cord-314013-g091lv0s	71	12	otherwise	otherwise	RB
cord-314013-g091lv0s	71	13	impaired	impair	VBN
cord-314013-g091lv0s	71	14	by	by	IN
cord-314013-g091lv0s	71	15	IL-6	IL-6	NNP
cord-314013-g091lv0s	71	16	,	,	,
cord-314013-g091lv0s	71	17	might	may	MD
cord-314013-g091lv0s	71	18	generate	generate	VB
cord-314013-g091lv0s	71	19	proper	proper	JJ
cord-314013-g091lv0s	71	20	levels	level	NNS
cord-314013-g091lv0s	71	21	of	of	IN
cord-314013-g091lv0s	71	22	Kyn	Kyn	NNP
cord-314013-g091lv0s	71	23	for	for	IN
cord-314013-g091lv0s	71	24	the	the	DT
cord-314013-g091lv0s	71	25	control	control	NN
cord-314013-g091lv0s	71	26	of	of	IN
cord-314013-g091lv0s	71	27	pulmonary	pulmonary	JJ
cord-314013-g091lv0s	71	28	hyperinflammation	hyperinflammation	NN
cord-314013-g091lv0s	71	29	and	and	CC
cord-314013-g091lv0s	71	30	hypertension	hypertension	NN
cord-314013-g091lv0s	71	31	.	.	.
cord-314013-g091lv0s	72	1	Several	several	JJ
cord-314013-g091lv0s	72	2	multi	multi	JJ
cord-314013-g091lv0s	72	3	-	-	JJ
cord-314013-g091lv0s	72	4	center	center	JJ
cord-314013-g091lv0s	72	5	,	,	,
cord-314013-g091lv0s	72	6	randomized	randomized	JJ
cord-314013-g091lv0s	72	7	controlled	control	VBN
cord-314013-g091lv0s	72	8	trials	trial	NNS
cord-314013-g091lv0s	72	9	for	for	IN
cord-314013-g091lv0s	72	10	assessing	assess	VBG
cord-314013-g091lv0s	72	11	the	the	DT
cord-314013-g091lv0s	72	12	efficacy	efficacy	NN
cord-314013-g091lv0s	72	13	and	and	CC
cord-314013-g091lv0s	72	14	tolerability	tolerability	NN
cord-314013-g091lv0s	72	15	of	of	IN
cord-314013-g091lv0s	72	16	TCZ	TCZ	NNP
cord-314013-g091lv0s	72	17	have	have	VBP
cord-314013-g091lv0s	72	18	been	be	VBN
cord-314013-g091lv0s	72	19	approved	approve	VBN
cord-314013-g091lv0s	72	20	in	in	IN
cord-314013-g091lv0s	72	21	patients	patient	NNS
cord-314013-g091lv0s	72	22	with	with	IN
cord-314013-g091lv0s	72	23	COVID-19	COVID-19	NNP
cord-314013-g091lv0s	72	24	pneumonia	pneumonia	NN
cord-314013-g091lv0s	72	25	.	.	.
cord-314013-g091lv0s	73	1	At	at	IN
cord-314013-g091lv0s	73	2	the	the	DT
cord-314013-g091lv0s	73	3	moment	moment	NN
cord-314013-g091lv0s	73	4	few	few	JJ
cord-314013-g091lv0s	73	5	data	datum	NNS
cord-314013-g091lv0s	73	6	are	be	VBP
cord-314013-g091lv0s	73	7	available	available	JJ
cord-314013-g091lv0s	73	8	.	.	.
cord-314013-g091lv0s	74	1	A	a	DT
cord-314013-g091lv0s	74	2	small	small	JJ
cord-314013-g091lv0s	74	3	clinical	clinical	JJ
cord-314013-g091lv0s	74	4	trial	trial	NN
cord-314013-g091lv0s	74	5	in	in	IN
cord-314013-g091lv0s	74	6	China	China	NNP
cord-314013-g091lv0s	74	7	(	(	-LRB-
cord-314013-g091lv0s	74	8	ID	ID	NNP
cord-314013-g091lv0s	74	9	:	:	:
cord-314013-g091lv0s	74	10	ChiCTR2000029765	chictr2000029765	ADD
cord-314013-g091lv0s	74	11	)	)	-RRB-
cord-314013-g091lv0s	74	12	,	,	,
cord-314013-g091lv0s	74	13	recruiting	recruit	VBG
cord-314013-g091lv0s	74	14	21	21	CD
cord-314013-g091lv0s	74	15	patients	patient	NNS
cord-314013-g091lv0s	74	16	with	with	IN
cord-314013-g091lv0s	74	17	severe	severe	JJ
cord-314013-g091lv0s	74	18	or	or	CC
cord-314013-g091lv0s	74	19	critical	critical	JJ
cord-314013-g091lv0s	74	20	COVID-19	COVID-19	NNP
cord-314013-g091lv0s	74	21	,	,	,
cord-314013-g091lv0s	74	22	has	have	VBZ
cord-314013-g091lv0s	74	23	shown	show	VBN
cord-314013-g091lv0s	74	24	good	good	JJ
cord-314013-g091lv0s	74	25	efficacy	efficacy	NN
cord-314013-g091lv0s	74	26	.	.	.
cord-314013-g091lv0s	75	1	The	the	DT
cord-314013-g091lv0s	75	2	remaining	remain	VBG
cord-314013-g091lv0s	75	3	approved	approve	VBN
cord-314013-g091lv0s	75	4	trials	trial	NNS
cord-314013-g091lv0s	75	5	are	be	VBP
cord-314013-g091lv0s	75	6	ongoing	ongoe	VBG
cord-314013-g091lv0s	75	7	all	all	RB
cord-314013-g091lv0s	75	8	over	over	IN
cord-314013-g091lv0s	75	9	the	the	DT
cord-314013-g091lv0s	75	10	world	world	NN
cord-314013-g091lv0s	75	11	.	.	.
cord-314013-g091lv0s	76	1	Based	base	VBN
cord-314013-g091lv0s	76	2	on	on	IN
cord-314013-g091lv0s	76	3	the	the	DT
cord-314013-g091lv0s	76	4	infection	infection	NN
cord-314013-g091lv0s	76	5	emergence	emergence	NN
cord-314013-g091lv0s	76	6	,	,	,
cord-314013-g091lv0s	76	7	strict	strict	JJ
cord-314013-g091lv0s	76	8	eligible	eligible	JJ
cord-314013-g091lv0s	76	9	criteria	criterion	NNS
cord-314013-g091lv0s	76	10	were	be	VBD
cord-314013-g091lv0s	76	11	adopted	adopt	VBN
cord-314013-g091lv0s	76	12	in	in	IN
cord-314013-g091lv0s	76	13	most	most	JJS
cord-314013-g091lv0s	76	14	studies	study	NNS
cord-314013-g091lv0s	76	15	for	for	IN
cord-314013-g091lv0s	76	16	the	the	DT
cord-314013-g091lv0s	76	17	recruitments	recruitment	NNS
cord-314013-g091lv0s	76	18	of	of	IN
cord-314013-g091lv0s	76	19	COVID-19	covid-19	JJ
cord-314013-g091lv0s	76	20	patients	patient	NNS
cord-314013-g091lv0s	76	21	.	.	.
cord-314013-g091lv0s	77	1	However	however	RB
cord-314013-g091lv0s	77	2	,	,	,
cord-314013-g091lv0s	77	3	few	few	JJ
cord-314013-g091lv0s	77	4	studies	study	NNS
cord-314013-g091lv0s	77	5	(	(	-LRB-
cord-314013-g091lv0s	77	6	i.e.	i.e.	FW
cord-314013-g091lv0s	77	7	,	,	,
cord-314013-g091lv0s	77	8	COVIDOSE	COVIDOSE	NNP
cord-314013-g091lv0s	77	9	,	,	,
cord-314013-g091lv0s	77	10	NCT04331795	NCT04331795	NNP
cord-314013-g091lv0s	77	11	)	)	-RRB-
cord-314013-g091lv0s	77	12	aim	aim	VBP
cord-314013-g091lv0s	77	13	to	to	TO
cord-314013-g091lv0s	77	14	titrate	titrate	VB
cord-314013-g091lv0s	77	15	TCZ	TCZ	NNP
cord-314013-g091lv0s	77	16	in	in	IN
cord-314013-g091lv0s	77	17	non	non	JJ
cord-314013-g091lv0s	77	18	-	-	JJ
cord-314013-g091lv0s	77	19	critically	critically	RB
cord-314013-g091lv0s	77	20	hospitalized	hospitalize	VBN
cord-314013-g091lv0s	77	21	ill	ill	JJ
cord-314013-g091lv0s	77	22	patients	patient	NNS
cord-314013-g091lv0s	77	23	,	,	,
cord-314013-g091lv0s	77	24	in	in	IN
cord-314013-g091lv0s	77	25	order	order	NN
cord-314013-g091lv0s	77	26	to	to	TO
cord-314013-g091lv0s	77	27	identify	identify	VB
cord-314013-g091lv0s	77	28	the	the	DT
cord-314013-g091lv0s	77	29	optimal	optimal	JJ
cord-314013-g091lv0s	77	30	timing	timing	NN
cord-314013-g091lv0s	77	31	to	to	TO
cord-314013-g091lv0s	77	32	treat	treat	VB
cord-314013-g091lv0s	77	33	them	-PRON-	PRP
cord-314013-g091lv0s	77	34	during	during	IN
cord-314013-g091lv0s	77	35	the	the	DT
cord-314013-g091lv0s	77	36	infection	infection	NN
cord-314013-g091lv0s	77	37	,	,	,
cord-314013-g091lv0s	77	38	to	to	TO
cord-314013-g091lv0s	77	39	personalize	personalize	VB
cord-314013-g091lv0s	77	40	TCZ	tcz	NN
cord-314013-g091lv0s	77	41	therapy	therapy	NN
cord-314013-g091lv0s	77	42	and	and	CC
cord-314013-g091lv0s	77	43	hopefully	hopefully	RB
cord-314013-g091lv0s	77	44	avoid	avoid	VB
cord-314013-g091lv0s	77	45	these	these	DT
cord-314013-g091lv0s	77	46	COVID-19	covid-19	JJ
cord-314013-g091lv0s	77	47	patients	patient	NNS
cord-314013-g091lv0s	77	48	intensive	intensive	JJ
cord-314013-g091lv0s	77	49	care	care	NN
cord-314013-g091lv0s	77	50	.	.	.
cord-314013-g091lv0s	78	1	In	in	IN
cord-314013-g091lv0s	78	2	addition	addition	NN
cord-314013-g091lv0s	78	3	to	to	IN
cord-314013-g091lv0s	78	4	clinical	clinical	JJ
cord-314013-g091lv0s	78	5	responses	response	NNS
cord-314013-g091lv0s	78	6	(	(	-LRB-
cord-314013-g091lv0s	78	7	i.e.	i.e.	FW
cord-314013-g091lv0s	78	8	,	,	,
cord-314013-g091lv0s	78	9	decreased	decrease	VBD
cord-314013-g091lv0s	78	10	mortality	mortality	NN
cord-314013-g091lv0s	78	11	incidence	incidence	NN
cord-314013-g091lv0s	78	12	,	,	,
cord-314013-g091lv0s	78	13	decreased	decrease	VBD
cord-314013-g091lv0s	78	14	fever	fever	NN
cord-314013-g091lv0s	78	15	,	,	,
cord-314013-g091lv0s	78	16	etc	etc	FW
cord-314013-g091lv0s	78	17	.	.	.
cord-314013-g091lv0s	78	18	)	)	-RRB-
cord-314013-g091lv0s	78	19	evaluated	evaluate	VBN
cord-314013-g091lv0s	78	20	as	as	IN
cord-314013-g091lv0s	78	21	primary	primary	JJ
cord-314013-g091lv0s	78	22	outcomes	outcome	NNS
cord-314013-g091lv0s	78	23	,	,	,
cord-314013-g091lv0s	78	24	a	a	DT
cord-314013-g091lv0s	78	25	series	series	NN
cord-314013-g091lv0s	78	26	of	of	IN
cord-314013-g091lv0s	78	27	biochemical	biochemical	JJ
cord-314013-g091lv0s	78	28	parameters	parameter	NNS
cord-314013-g091lv0s	78	29	are	be	VBP
cord-314013-g091lv0s	78	30	also	also	RB
cord-314013-g091lv0s	78	31	monitored	monitor	VBN
cord-314013-g091lv0s	78	32	FIGURE	figure	NN
cord-314013-g091lv0s	78	33	1	1	CD
cord-314013-g091lv0s	78	34	|	|	NNP
cord-314013-g091lv0s	78	35	Potential	potential	JJ
cord-314013-g091lv0s	78	36	regulatory	regulatory	JJ
cord-314013-g091lv0s	78	37	mechanisms	mechanism	NNS
cord-314013-g091lv0s	78	38	activated	activate	VBN
cord-314013-g091lv0s	78	39	by	by	IN
cord-314013-g091lv0s	78	40	TCZ	TCZ	NNP
cord-314013-g091lv0s	78	41	therapy	therapy	NN
cord-314013-g091lv0s	78	42	in	in	IN
cord-314013-g091lv0s	78	43	COVID-19	COVID-19	NNP
cord-314013-g091lv0s	78	44	patients	patient	NNS
cord-314013-g091lv0s	78	45	.	.	.
cord-314013-g091lv0s	79	1	COVID-19	COVID-19	NNP
cord-314013-g091lv0s	79	2	is	be	VBZ
cord-314013-g091lv0s	79	3	associated	associate	VBN
cord-314013-g091lv0s	79	4	to	to	IN
cord-314013-g091lv0s	79	5	a	a	DT
cord-314013-g091lv0s	79	6	CRS	CRS	NNP
cord-314013-g091lv0s	79	7	referred	refer	VBN
cord-314013-g091lv0s	79	8	as	as	IN
cord-314013-g091lv0s	79	9	"	"	``
cord-314013-g091lv0s	79	10	cytokine	cytokine	NN
cord-314013-g091lv0s	79	11	storm	storm	NN
cord-314013-g091lv0s	79	12	"	"	''
cord-314013-g091lv0s	79	13	(	(	-LRB-
cord-314013-g091lv0s	79	14	A	a	NN
cord-314013-g091lv0s	79	15	)	)	-RRB-
cord-314013-g091lv0s	79	16	,	,	,
cord-314013-g091lv0s	79	17	whose	whose	WP$
cord-314013-g091lv0s	79	18	reduction	reduction	NN
cord-314013-g091lv0s	79	19	at	at	IN
cord-314013-g091lv0s	79	20	lung	lung	NN
cord-314013-g091lv0s	79	21	level	level	NN
cord-314013-g091lv0s	79	22	(	(	-LRB-
cord-314013-g091lv0s	79	23	the	the	DT
cord-314013-g091lv0s	79	24	main	main	JJ
cord-314013-g091lv0s	79	25	target	target	NN
cord-314013-g091lv0s	79	26	organ	organ	NN
cord-314013-g091lv0s	79	27	of	of	IN
cord-314013-g091lv0s	79	28	SARS	SARS	NNP
cord-314013-g091lv0s	79	29	-	-	HYPH
cord-314013-g091lv0s	79	30	CoV2	cov2	NN
cord-314013-g091lv0s	79	31	viral	viral	JJ
cord-314013-g091lv0s	79	32	infection	infection	NN
cord-314013-g091lv0s	79	33	)	)	-RRB-
cord-314013-g091lv0s	79	34	may	may	MD
cord-314013-g091lv0s	79	35	be	be	VB
cord-314013-g091lv0s	79	36	achieved	achieve	VBN
cord-314013-g091lv0s	79	37	by	by	IN
cord-314013-g091lv0s	79	38	TCZ	tcz	NN
cord-314013-g091lv0s	79	39	therapy	therapy	NN
cord-314013-g091lv0s	79	40	inhibiting	inhibit	VBG
cord-314013-g091lv0s	79	41	IL-6	IL-6	NNP
cord-314013-g091lv0s	79	42	proinflammatory	proinflammatory	JJ
cord-314013-g091lv0s	79	43	effect	effect	NN
cord-314013-g091lv0s	79	44	(	(	-LRB-
cord-314013-g091lv0s	79	45	B	b	NN
cord-314013-g091lv0s	79	46	)	)	-RRB-
cord-314013-g091lv0s	79	47	.	.	.
cord-314013-g091lv0s	80	1	Neutralization	neutralization	NN
cord-314013-g091lv0s	80	2	of	of	IN
cord-314013-g091lv0s	80	3	IL-6	IL-6	NNP
cord-314013-g091lv0s	80	4	biological	biological	JJ
cord-314013-g091lv0s	80	5	activity	activity	NN
cord-314013-g091lv0s	80	6	by	by	IN
cord-314013-g091lv0s	80	7	TCZ	TCZ	NNP
cord-314013-g091lv0s	80	8	potentiates	potentiate	VBZ
cord-314013-g091lv0s	80	9	IDO1-mediated	ido1-mediated	JJ
cord-314013-g091lv0s	80	10	conversion	conversion	NN
cord-314013-g091lv0s	80	11	of	of	IN
cord-314013-g091lv0s	80	12	the	the	DT
cord-314013-g091lv0s	80	13	amino	amino	NN
cord-314013-g091lv0s	80	14	acid	acid	NN
cord-314013-g091lv0s	80	15	Trp	Trp	NNP
cord-314013-g091lv0s	80	16	into	into	IN
cord-314013-g091lv0s	80	17	its	-PRON-	PRP$
cord-314013-g091lv0s	80	18	catabolite	catabolite	JJ
cord-314013-g091lv0s	80	19	Kyn	Kyn	NNP
cord-314013-g091lv0s	80	20	(	(	-LRB-
cord-314013-g091lv0s	80	21	C	C	NNP
cord-314013-g091lv0s	80	22	)	)	-RRB-
cord-314013-g091lv0s	80	23	.	.	.
cord-314013-g091lv0s	81	1	Increased	increase	VBN
cord-314013-g091lv0s	81	2	level	level	NN
cord-314013-g091lv0s	81	3	of	of	IN
cord-314013-g091lv0s	81	4	circulating	circulate	VBG
cord-314013-g091lv0s	81	5	Kyn	Kyn	NNP
cord-314013-g091lv0s	81	6	contributes	contribute	VBZ
cord-314013-g091lv0s	81	7	to	to	TO
cord-314013-g091lv0s	81	8	control	control	VB
cord-314013-g091lv0s	81	9	pulmonary	pulmonary	JJ
cord-314013-g091lv0s	81	10	hypertension	hypertension	NN
cord-314013-g091lv0s	81	11	and	and	CC
cord-314013-g091lv0s	81	12	inflammation	inflammation	NN
cord-314013-g091lv0s	81	13	,	,	,
cord-314013-g091lv0s	81	14	and	and	CC
cord-314013-g091lv0s	81	15	to	to	TO
cord-314013-g091lv0s	81	16	promote	promote	VB
cord-314013-g091lv0s	81	17	immunoregulation	immunoregulation	NN
cord-314013-g091lv0s	81	18	in	in	IN
cord-314013-g091lv0s	81	19	COVID-19	COVID-19	NNP
cord-314013-g091lv0s	81	20	patients	patient	NNS
cord-314013-g091lv0s	81	21	.	.	.
cord-314013-g091lv0s	82	1	as	as	IN
cord-314013-g091lv0s	82	2	secondary	secondary	JJ
cord-314013-g091lv0s	82	3	outcomes	outcome	NNS
cord-314013-g091lv0s	82	4	,	,	,
cord-314013-g091lv0s	82	5	that	that	RB
cord-314013-g091lv0s	82	6	is	is	RB
cord-314013-g091lv0s	82	7	,	,	,
cord-314013-g091lv0s	82	8	levels	level	NNS
cord-314013-g091lv0s	82	9	of	of	IN
cord-314013-g091lv0s	82	10	circulating	circulate	VBG
cord-314013-g091lv0s	82	11	IL-6	IL-6	NNP
cord-314013-g091lv0s	82	12	and	and	CC
cord-314013-g091lv0s	82	13	Creactive	Creactive	NNP
cord-314013-g091lv0s	82	14	protein	protein	NN
cord-314013-g091lv0s	82	15	,	,	,
cord-314013-g091lv0s	82	16	leukocytes	leukocyte	NNS
cord-314013-g091lv0s	82	17	count	count	VBP
cord-314013-g091lv0s	82	18	,	,	,
cord-314013-g091lv0s	82	19	and	and	CC
cord-314013-g091lv0s	82	20	oxygen	oxygen	NN
cord-314013-g091lv0s	82	21	saturation	saturation	NN
cord-314013-g091lv0s	82	22	.	.	.
cord-314013-g091lv0s	83	1	Solid	solid	JJ
cord-314013-g091lv0s	83	2	published	publish	VBN
cord-314013-g091lv0s	83	3	results	result	NNS
cord-314013-g091lv0s	83	4	demonstrated	demonstrate	VBD
cord-314013-g091lv0s	83	5	a	a	DT
cord-314013-g091lv0s	83	6	close	close	JJ
cord-314013-g091lv0s	83	7	relationship	relationship	NN
cord-314013-g091lv0s	83	8	between	between	IN
cord-314013-g091lv0s	83	9	TCZ	TCZ	NNP
cord-314013-g091lv0s	83	10	action	action	NN
cord-314013-g091lv0s	83	11	and	and	CC
cord-314013-g091lv0s	83	12	an	an	DT
cord-314013-g091lv0s	83	13	increased	increase	VBN
cord-314013-g091lv0s	83	14	Trp	trp	NN
cord-314013-g091lv0s	83	15	catabolism	catabolism	NN
cord-314013-g091lv0s	83	16	in	in	IN
cord-314013-g091lv0s	83	17	different	different	JJ
cord-314013-g091lv0s	83	18	inflammatory	inflammatory	JJ
cord-314013-g091lv0s	83	19	settings	setting	NNS
cord-314013-g091lv0s	83	20	driven	drive	VBN
cord-314013-g091lv0s	83	21	by	by	IN
cord-314013-g091lv0s	84	1	IL-6	IL-6	NNP
cord-314013-g091lv0s	84	2	(	(	-LRB-
cord-314013-g091lv0s	84	3	Orabona	Orabona	NNP
cord-314013-g091lv0s	84	4	et	et	NNP
cord-314013-g091lv0s	84	5	al	al	NNP
cord-314013-g091lv0s	84	6	.	.	NNP
cord-314013-g091lv0s	84	7	,	,	,
cord-314013-g091lv0s	84	8	2008	2008	CD
cord-314013-g091lv0s	85	1	;	;	:
cord-314013-g091lv0s	85	2	Mondanelli	Mondanelli	NNP
cord-314013-g091lv0s	85	3	et	et	NNP
cord-314013-g091lv0s	85	4	al	al	NNP
cord-314013-g091lv0s	85	5	.	.	NNP
cord-314013-g091lv0s	85	6	,	,	,
cord-314013-g091lv0s	85	7	2017	2017	CD
cord-314013-g091lv0s	85	8	;	;	:
cord-314013-g091lv0s	85	9	Orabona	Orabona	NNP
cord-314013-g091lv0s	85	10	et	et	NNP
cord-314013-g091lv0s	85	11	al	al	NNP
cord-314013-g091lv0s	85	12	.	.	NNP
cord-314013-g091lv0s	85	13	,	,	,
cord-314013-g091lv0s	85	14	2018	2018	CD
cord-314013-g091lv0s	85	15	)	)	-RRB-
cord-314013-g091lv0s	85	16	,	,	,
cord-314013-g091lv0s	85	17	suggesting	suggest	VBG
cord-314013-g091lv0s	85	18	the	the	DT
cord-314013-g091lv0s	85	19	possibility	possibility	NN
cord-314013-g091lv0s	85	20	and	and	CC
cord-314013-g091lv0s	85	21	relevance	relevance	NN
cord-314013-g091lv0s	85	22	of	of	IN
cord-314013-g091lv0s	85	23	monitoring	monitor	VBG
cord-314013-g091lv0s	85	24	Trp	trp	NN
cord-314013-g091lv0s	85	25	metabolism	metabolism	NN
cord-314013-g091lv0s	85	26	in	in	IN
cord-314013-g091lv0s	85	27	COVID-19	covid-19	JJ
cord-314013-g091lv0s	85	28	patients	patient	NNS
cord-314013-g091lv0s	85	29	on	on	IN
cord-314013-g091lv0s	85	30	TCZ	tcz	NN
cord-314013-g091lv0s	85	31	therapy	therapy	NN
cord-314013-g091lv0s	85	32	.	.	.
cord-314013-g091lv0s	86	1	The	the	DT
cord-314013-g091lv0s	86	2	ratio	ratio	NN
cord-314013-g091lv0s	86	3	between	between	IN
cord-314013-g091lv0s	86	4	circulating	circulate	VBG
cord-314013-g091lv0s	86	5	Kyn	Kyn	NNP
cord-314013-g091lv0s	86	6	and	and	CC
cord-314013-g091lv0s	86	7	Trp	Trp	NNP
cord-314013-g091lv0s	86	8	(	(	-LRB-
cord-314013-g091lv0s	86	9	Kyn	Kyn	NNP
cord-314013-g091lv0s	86	10	/	/	SYM
cord-314013-g091lv0s	86	11	Trp	Trp	NNP
cord-314013-g091lv0s	86	12	)	)	-RRB-
cord-314013-g091lv0s	86	13	in	in	IN
cord-314013-g091lv0s	86	14	patients	patient	NNS
cord-314013-g091lv0s	86	15	'	'	POS
cord-314013-g091lv0s	86	16	sera	sera	NNP
cord-314013-g091lv0s	86	17	might	may	MD
cord-314013-g091lv0s	86	18	represent	represent	VB
cord-314013-g091lv0s	86	19	a	a	DT
cord-314013-g091lv0s	86	20	biomarker	biomarker	NN
cord-314013-g091lv0s	86	21	for	for	IN
cord-314013-g091lv0s	86	22	assessing	assess	VBG
cord-314013-g091lv0s	86	23	IDO1	IDO1	NNP
cord-314013-g091lv0s	86	24	activity	activity	NN
cord-314013-g091lv0s	86	25	and	and	CC
cord-314013-g091lv0s	86	26	a	a	DT
cord-314013-g091lv0s	86	27	surrogate	surrogate	JJ
cord-314013-g091lv0s	86	28	biomarker	biomarker	NN
cord-314013-g091lv0s	86	29	for	for	IN
cord-314013-g091lv0s	86	30	tracking	track	VBG
cord-314013-g091lv0s	86	31	immunoregulation	immunoregulation	NN
cord-314013-g091lv0s	86	32	mediated	mediate	VBN
cord-314013-g091lv0s	86	33	by	by	IN
cord-314013-g091lv0s	86	34	Trp	Trp	NNP
cord-314013-g091lv0s	86	35	catabolism	catabolism	NN
cord-314013-g091lv0s	86	36	.	.	.
cord-314013-g091lv0s	87	1	In	in	IN
cord-314013-g091lv0s	87	2	conclusion	conclusion	NN
cord-314013-g091lv0s	87	3	,	,	,
cord-314013-g091lv0s	87	4	IL-6-mediated	il-6-mediated	JJ
cord-314013-g091lv0s	87	5	inflammation	inflammation	NN
cord-314013-g091lv0s	87	6	in	in	IN
cord-314013-g091lv0s	87	7	COVID-19	COVID-19	NNP
cord-314013-g091lv0s	87	8	might	may	MD
cord-314013-g091lv0s	87	9	affect	affect	VB
cord-314013-g091lv0s	87	10	Trp	Trp	NNP
cord-314013-g091lv0s	87	11	catabolism	catabolism	NN
cord-314013-g091lv0s	87	12	,	,	,
cord-314013-g091lv0s	87	13	as	as	IN
cord-314013-g091lv0s	87	14	observed	observe	VBN
cord-314013-g091lv0s	87	15	in	in	IN
cord-314013-g091lv0s	87	16	autoimmune	autoimmune	JJ
cord-314013-g091lv0s	87	17	diabetes	diabete	NNS
cord-314013-g091lv0s	87	18	and	and	CC
cord-314013-g091lv0s	87	19	other	other	JJ
cord-314013-g091lv0s	87	20	experimental	experimental	JJ
cord-314013-g091lv0s	87	21	conditions	condition	NNS
cord-314013-g091lv0s	87	22	.	.	.
cord-314013-g091lv0s	88	1	TCZ	tcz	NN
cord-314013-g091lv0s	88	2	treatment	treatment	NN
cord-314013-g091lv0s	88	3	might	may	MD
cord-314013-g091lv0s	88	4	restore	restore	VB
cord-314013-g091lv0s	88	5	a	a	DT
cord-314013-g091lv0s	88	6	proper	proper	JJ
cord-314013-g091lv0s	88	7	IDO1	IDO1	NNP
cord-314013-g091lv0s	88	8	activity	activity	NN
cord-314013-g091lv0s	88	9	,	,	,
cord-314013-g091lv0s	88	10	providing	provide	VBG
cord-314013-g091lv0s	88	11	immunoactive	immunoactive	JJ
cord-314013-g091lv0s	88	12	Kyn	Kyn	NNP
cord-314013-g091lv0s	88	13	as	as	IN
cord-314013-g091lv0s	88	14	a	a	DT
cord-314013-g091lv0s	88	15	ligand	ligand	NN
cord-314013-g091lv0s	88	16	for	for	IN
cord-314013-g091lv0s	88	17	AhR	ahr	NN
cord-314013-g091lv0s	88	18	-	-	HYPH
cord-314013-g091lv0s	88	19	dependent	dependent	JJ
cord-314013-g091lv0s	88	20	immune	immune	JJ
cord-314013-g091lv0s	88	21	regulation	regulation	NN
cord-314013-g091lv0s	88	22	,	,	,
cord-314013-g091lv0s	88	23	including	include	VBG
cord-314013-g091lv0s	88	24	the	the	DT
cord-314013-g091lv0s	88	25	fostering	fostering	NN
cord-314013-g091lv0s	88	26	of	of	IN
cord-314013-g091lv0s	88	27	T	t	NN
cord-314013-g091lv0s	88	28	-	-	HYPH
cord-314013-g091lv0s	88	29	regulatory	regulatory	JJ
cord-314013-g091lv0s	88	30	cell	cell	NN
cord-314013-g091lv0s	88	31	responses	response	NNS
cord-314013-g091lv0s	88	32	.	.	.
cord-314013-g091lv0s	89	1	This	this	DT
cord-314013-g091lv0s	89	2	might	may	MD
cord-314013-g091lv0s	89	3	alleviate	alleviate	VB
cord-314013-g091lv0s	89	4	local	local	JJ
cord-314013-g091lv0s	89	5	and	and	CC
cord-314013-g091lv0s	89	6	systemic	systemic	JJ
cord-314013-g091lv0s	89	7	hyperinflammatory	hyperinflammatory	JJ
cord-314013-g091lv0s	89	8	responses	response	NNS
cord-314013-g091lv0s	89	9	in	in	IN
cord-314013-g091lv0s	89	10	COVID-19	COVID-19	NNP
cord-314013-g091lv0s	89	11	patients	patient	NNS
cord-314013-g091lv0s	89	12	.	.	.
cord-314013-g091lv0s	90	1	Currently	currently	RB
cord-314013-g091lv0s	90	2	,	,	,
cord-314013-g091lv0s	90	3	TCZ	TCZ	NNP
cord-314013-g091lv0s	90	4	is	be	VBZ
cord-314013-g091lv0s	90	5	clinically	clinically	RB
cord-314013-g091lv0s	90	6	trialed	triale	VBN
cord-314013-g091lv0s	90	7	for	for	IN
cord-314013-g091lv0s	90	8	targeting	target	VBG
cord-314013-g091lv0s	90	9	IL-6R	IL-6R	NNP
cord-314013-g091lv0s	90	10	in	in	IN
cord-314013-g091lv0s	90	11	COVID-19	covid-19	JJ
cord-314013-g091lv0s	90	12	patients	patient	NNS
cord-314013-g091lv0s	90	13	.	.	.
cord-314013-g091lv0s	91	1	These	these	DT
cord-314013-g091lv0s	91	2	studies	study	NNS
cord-314013-g091lv0s	91	3	offer	offer	VBP
cord-314013-g091lv0s	91	4	the	the	DT
cord-314013-g091lv0s	91	5	opportunity	opportunity	NN
cord-314013-g091lv0s	91	6	of	of	IN
cord-314013-g091lv0s	91	7	molecularly	molecularly	RB
cord-314013-g091lv0s	91	8	dissecting	dissect	VBG
cord-314013-g091lv0s	91	9	synergic	synergic	NN
cord-314013-g091lv0s	91	10	mechanisms	mechanism	NNS
cord-314013-g091lv0s	91	11	capable	capable	JJ
cord-314013-g091lv0s	91	12	to	to	TO
cord-314013-g091lv0s	91	13	mitigate	mitigate	VB
cord-314013-g091lv0s	91	14	COVID-19-related	covid-19-related	JJ
cord-314013-g091lv0s	91	15	symptoms	symptom	NNS
cord-314013-g091lv0s	91	16	,	,	,
cord-314013-g091lv0s	91	17	opening	open	VBG
cord-314013-g091lv0s	91	18	the	the	DT
cord-314013-g091lv0s	91	19	way	way	NN
cord-314013-g091lv0s	91	20	for	for	IN
cord-314013-g091lv0s	91	21	the	the	DT
cord-314013-g091lv0s	91	22	setting	setting	NN
cord-314013-g091lv0s	91	23	of	of	IN
cord-314013-g091lv0s	91	24	innovative	innovative	JJ
cord-314013-g091lv0s	91	25	combined	combine	VBN
cord-314013-g091lv0s	91	26	therapies	therapy	NNS
cord-314013-g091lv0s	91	27	.	.	.
cord-314013-g091lv0s	92	1	MB	MB	NNP
cord-314013-g091lv0s	92	2	wrote	write	VBD
cord-314013-g091lv0s	92	3	the	the	DT
cord-314013-g091lv0s	92	4	manuscript	manuscript	NN
cord-314013-g091lv0s	92	5	and	and	CC
cord-314013-g091lv0s	92	6	edited	edit	VBD
cord-314013-g091lv0s	92	7	the	the	DT
cord-314013-g091lv0s	92	8	figure	figure	NN
cord-314013-g091lv0s	92	9	.	.	.
cord-314013-g091lv0s	93	1	CO	CO	NNP
cord-314013-g091lv0s	93	2	wrote	write	VBD
cord-314013-g091lv0s	93	3	and	and	CC
cord-314013-g091lv0s	93	4	revised	revise	VBD
cord-314013-g091lv0s	93	5	the	the	DT
cord-314013-g091lv0s	93	6	manuscript	manuscript	NN
cord-314013-g091lv0s	93	7	.	.	.
cord-314013-g091lv0s	94	1	This	this	DT
cord-314013-g091lv0s	94	2	work	work	NN
cord-314013-g091lv0s	94	3	was	be	VBD
cord-314013-g091lv0s	94	4	supported	support	VBN
cord-314013-g091lv0s	94	5	by	by	IN
cord-314013-g091lv0s	94	6	the	the	DT
cord-314013-g091lv0s	94	7	Italian	italian	JJ
cord-314013-g091lv0s	94	8	Ministry	Ministry	NNP
cord-314013-g091lv0s	94	9	of	of	IN
cord-314013-g091lv0s	94	10	Education	Education	NNP
cord-314013-g091lv0s	94	11	,	,	,
cord-314013-g091lv0s	94	12	Universities	Universities	NNPS
cord-314013-g091lv0s	94	13	and	and	CC
cord-314013-g091lv0s	94	14	Research	Research	NNP
cord-314013-g091lv0s	94	15	(	(	-LRB-
cord-314013-g091lv0s	94	16	PRIN2017	PRIN2017	NNP
cord-314013-g091lv0s	94	17	-	-	HYPH
cord-314013-g091lv0s	94	18	2017BA9LM5	2017ba9lm5	CD
cord-314013-g091lv0s	94	19	to	to	IN
cord-314013-g091lv0s	94	20	CO	CO	NNP
cord-314013-g091lv0s	94	21	)	)	-RRB-
cord-314013-g091lv0s	94	22	.	.	.
cord-314013-g091lv0s	95	1	Aryl	Aryl	NNP
cord-314013-g091lv0s	95	2	hydrocarbon	hydrocarbon	NN
cord-314013-g091lv0s	95	3	receptor	receptor	NN
cord-314013-g091lv0s	95	4	control	control	NN
cord-314013-g091lv0s	95	5	of	of	IN
cord-314013-g091lv0s	95	6	a	a	DT
cord-314013-g091lv0s	95	7	disease	disease	NN
cord-314013-g091lv0s	95	8	tolerance	tolerance	NN
cord-314013-g091lv0s	95	9	defence	defence	NN
cord-314013-g091lv0s	95	10	pathway	pathway	NN
cord-314013-g091lv0s	95	11	Epidemiology	epidemiology	NN
cord-314013-g091lv0s	95	12	and	and	CC
cord-314013-g091lv0s	95	13	transmission	transmission	NN
cord-314013-g091lv0s	95	14	of	of	IN
cord-314013-g091lv0s	95	15	COVID-19	covid-19	CD
cord-314013-g091lv0s	95	16	in	in	IN
cord-314013-g091lv0s	95	17	391	391	CD
cord-314013-g091lv0s	95	18	cases	case	NNS
cord-314013-g091lv0s	95	19	and	and	CC
cord-314013-g091lv0s	95	20	1286	1286	CD
cord-314013-g091lv0s	95	21	of	of	IN
cord-314013-g091lv0s	95	22	their	-PRON-	PRP$
cord-314013-g091lv0s	95	23	close	close	JJ
cord-314013-g091lv0s	95	24	contacts	contact	NNS
cord-314013-g091lv0s	95	25	in	in	IN
cord-314013-g091lv0s	95	26	Shenzhen	Shenzhen	NNP
cord-314013-g091lv0s	95	27	,	,	,
cord-314013-g091lv0s	95	28	China	China	NNP
cord-314013-g091lv0s	95	29	:	:	:
cord-314013-g091lv0s	96	1	a	a	DT
cord-314013-g091lv0s	96	2	retrospective	retrospective	JJ
cord-314013-g091lv0s	96	3	cohort	cohort	NN
cord-314013-g091lv0s	96	4	study	study	NN
cord-314013-g091lv0s	96	5	The	the	DT
cord-314013-g091lv0s	96	6	first	first	JJ
cord-314013-g091lv0s	96	7	two	two	CD
cord-314013-g091lv0s	96	8	cases	case	NNS
cord-314013-g091lv0s	96	9	of	of	IN
cord-314013-g091lv0s	96	10	2019-nCoV	2019-ncov	CD
cord-314013-g091lv0s	96	11	in	in	IN
cord-314013-g091lv0s	96	12	Italy	Italy	NNP
cord-314013-g091lv0s	96	13	:	:	:
cord-314013-g091lv0s	97	1	Where	where	WRB
cord-314013-g091lv0s	97	2	they	-PRON-	PRP
cord-314013-g091lv0s	97	3	come	come	VBP
cord-314013-g091lv0s	97	4	from	from	IN
cord-314013-g091lv0s	97	5	?	?	.
cord-314013-g091lv0s	98	1	Amino	amino	NN
cord-314013-g091lv0s	98	2	-	-	HYPH
cord-314013-g091lv0s	98	3	acid	acid	NN
cord-314013-g091lv0s	98	4	sensing	sensing	NN
cord-314013-g091lv0s	98	5	and	and	CC
cord-314013-g091lv0s	98	6	degrading	degrade	VBG
cord-314013-g091lv0s	98	7	pathways	pathway	NNS
cord-314013-g091lv0s	98	8	in	in	IN
cord-314013-g091lv0s	98	9	immune	immune	JJ
cord-314013-g091lv0s	98	10	regulation	regulation	NN
cord-314013-g091lv0s	99	1	Clinical	clinical	JJ
cord-314013-g091lv0s	99	2	features	feature	NNS
cord-314013-g091lv0s	99	3	of	of	IN
cord-314013-g091lv0s	99	4	patients	patient	NNS
cord-314013-g091lv0s	99	5	infected	infect	VBN
cord-314013-g091lv0s	99	6	with	with	IN
cord-314013-g091lv0s	99	7	2019	2019	CD
cord-314013-g091lv0s	99	8	novel	novel	JJ
cord-314013-g091lv0s	99	9	coronavirus	coronavirus	NN
cord-314013-g091lv0s	99	10	in	in	IN
cord-314013-g091lv0s	99	11	Wuhan	Wuhan	NNP
cord-314013-g091lv0s	99	12	,	,	,
cord-314013-g091lv0s	99	13	China	China	NNP
cord-314013-g091lv0s	99	14	Pharmacologic	Pharmacologic	NNP
cord-314013-g091lv0s	99	15	Induction	Induction	NNP
cord-314013-g091lv0s	99	16	of	of	IN
cord-314013-g091lv0s	99	17	Endotoxin	Endotoxin	NNP
cord-314013-g091lv0s	99	18	Tolerance	tolerance	NN
cord-314013-g091lv0s	99	19	in	in	IN
cord-314013-g091lv0s	99	20	Dendritic	Dendritic	NNP
cord-314013-g091lv0s	99	21	Cells	Cells	NNPS
cord-314013-g091lv0s	99	22	by	by	IN
cord-314013-g091lv0s	99	23	L	L	NNP
cord-314013-g091lv0s	99	24	-	-	HYPH
cord-314013-g091lv0s	99	25	Kynurenine	Kynurenine	NNP
cord-314013-g091lv0s	100	1	The	the	DT
cord-314013-g091lv0s	100	2	Proteasome	Proteasome	NNP
cord-314013-g091lv0s	100	3	Inhibitor	Inhibitor	NNP
cord-314013-g091lv0s	100	4	Bortezomib	Bortezomib	NNP
cord-314013-g091lv0s	100	5	Controls	control	VBZ
cord-314013-g091lv0s	100	6	Indoleamine	Indoleamine	NNP
cord-314013-g091lv0s	101	1	2,3-Dioxygenase	2,3-dioxygenase	CD
cord-314013-g091lv0s	101	2	1	1	CD
cord-314013-g091lv0s	101	3	Breakdown	Breakdown	NNP
cord-314013-g091lv0s	101	4	and	and	CC
cord-314013-g091lv0s	101	5	Restores	restore	VBZ
cord-314013-g091lv0s	101	6	Immune	Immune	NNP
cord-314013-g091lv0s	101	7	Regulation	regulation	NN
cord-314013-g091lv0s	101	8	in	in	IN
cord-314013-g091lv0s	101	9	Autoimmune	Autoimmune	NNP
cord-314013-g091lv0s	101	10	Diabetes	Diabetes	NNP
cord-314013-g091lv0s	101	11	Importance	importance	NN
cord-314013-g091lv0s	101	12	of	of	IN
cord-314013-g091lv0s	101	13	kynurenine	kynurenine	NN
cord-314013-g091lv0s	101	14	in	in	IN
cord-314013-g091lv0s	101	15	pulmonary	pulmonary	JJ
cord-314013-g091lv0s	101	16	hypertension	hypertension	NN
cord-314013-g091lv0s	101	17	SOCS3	SOCS3	NNP
cord-314013-g091lv0s	101	18	drives	drive	VBZ
cord-314013-g091lv0s	101	19	proteasomal	proteasomal	JJ
cord-314013-g091lv0s	101	20	degradation	degradation	NN
cord-314013-g091lv0s	101	21	of	of	IN
cord-314013-g091lv0s	101	22	indoleamine	indoleamine	NN
cord-314013-g091lv0s	101	23	2,3-dioxygenase	2,3-dioxygenase	CD
cord-314013-g091lv0s	101	24	(	(	-LRB-
cord-314013-g091lv0s	101	25	IDO	IDO	NNP
cord-314013-g091lv0s	101	26	)	)	-RRB-
cord-314013-g091lv0s	101	27	and	and	CC
cord-314013-g091lv0s	101	28	antagonizes	antagonize	VBZ
cord-314013-g091lv0s	101	29	IDO	IDO	NNP
cord-314013-g091lv0s	101	30	-	-	HYPH
cord-314013-g091lv0s	101	31	dependent	dependent	JJ
cord-314013-g091lv0s	101	32	tolerogenesis	tolerogenesis	NN
cord-314013-g091lv0s	101	33	Different	different	JJ
cord-314013-g091lv0s	101	34	partners	partner	NNS
cord-314013-g091lv0s	101	35	,	,	,
cord-314013-g091lv0s	101	36	opposite	opposite	JJ
cord-314013-g091lv0s	101	37	outcomes	outcome	NNS
cord-314013-g091lv0s	101	38	:	:	:
cord-314013-g091lv0s	101	39	a	a	DT
cord-314013-g091lv0s	101	40	new	new	JJ
cord-314013-g091lv0s	101	41	perspective	perspective	NN
cord-314013-g091lv0s	101	42	of	of	IN
cord-314013-g091lv0s	101	43	the	the	DT
cord-314013-g091lv0s	101	44	immunobiology	immunobiology	NN
cord-314013-g091lv0s	101	45	of	of	IN
cord-314013-g091lv0s	101	46	indoleamine	indoleamine	NNP
cord-314013-g091lv0s	101	47	2,3-dioxygenase	2,3-dioxygenase	CD
cord-314013-g091lv0s	101	48	Deficiency	Deficiency	NNP
cord-314013-g091lv0s	101	49	of	of	IN
cord-314013-g091lv0s	101	50	immunoregulatory	immunoregulatory	NNP
cord-314013-g091lv0s	101	51	indoleamine	indoleamine	NNP
cord-314013-g091lv0s	101	52	2,3-dioxygenase	2,3-dioxygenase	NNP
cord-314013-g091lv0s	101	53	1	1	CD
cord-314013-g091lv0s	101	54	in	in	IN
cord-314013-g091lv0s	101	55	juvenile	juvenile	JJ
cord-314013-g091lv0s	101	56	diabetes	diabete	NNS
cord-314013-g091lv0s	102	1	SARS	SARS	NNP
cord-314013-g091lv0s	102	2	-	-	HYPH
cord-314013-g091lv0s	102	3	CoV-2	CoV-2	NNP
cord-314013-g091lv0s	102	4	:	:	:
cord-314013-g091lv0s	103	1	a	a	DT
cord-314013-g091lv0s	103	2	storm	storm	NN
cord-314013-g091lv0s	103	3	is	be	VBZ
cord-314013-g091lv0s	103	4	raging	rage	VBG
cord-314013-g091lv0s	103	5	Immunopathogenesis	Immunopathogenesis	NNP
cord-314013-g091lv0s	103	6	of	of	IN
cord-314013-g091lv0s	103	7	coronavirus	coronavirus	NN
cord-314013-g091lv0s	103	8	infections	infection	NNS
cord-314013-g091lv0s	103	9	:	:	:
cord-314013-g091lv0s	103	10	implications	implication	NNS
cord-314013-g091lv0s	103	11	for	for	IN
cord-314013-g091lv0s	103	12	SARS	SARS	NNP
cord-314013-g091lv0s	103	13	Immune	Immune	NNP
cord-314013-g091lv0s	103	14	responses	response	NNS
cord-314013-g091lv0s	103	15	in	in	IN
cord-314013-g091lv0s	103	16	COVID-19	covid-19	JJ
cord-314013-g091lv0s	103	17	and	and	CC
cord-314013-g091lv0s	103	18	potential	potential	JJ
cord-314013-g091lv0s	103	19	vaccines	vaccine	NNS
cord-314013-g091lv0s	103	20	:	:	:
cord-314013-g091lv0s	103	21	Lessons	lesson	NNS
cord-314013-g091lv0s	103	22	learned	learn	VBN
cord-314013-g091lv0s	103	23	from	from	IN
cord-314013-g091lv0s	103	24	SARS	SARS	NNP
cord-314013-g091lv0s	103	25	and	and	CC
cord-314013-g091lv0s	103	26	MERS	MERS	NNP
cord-314013-g091lv0s	103	27	epidemic	epidemic	NN
cord-314013-g091lv0s	103	28	Control	Control	NNP
cord-314013-g091lv0s	103	29	of	of	IN
cord-314013-g091lv0s	103	30	T(reg	T(reg	NNP
cord-314013-g091lv0s	103	31	)	)	-RRB-
cord-314013-g091lv0s	103	32	and	and	CC
cord-314013-g091lv0s	103	33	T(H)17	T(H)17	VBZ
cord-314013-g091lv0s	103	34	cell	cell	NN
cord-314013-g091lv0s	103	35	differentiation	differentiation	NN
cord-314013-g091lv0s	103	36	by	by	IN
cord-314013-g091lv0s	103	37	the	the	DT
cord-314013-g091lv0s	103	38	aryl	aryl	NN
cord-314013-g091lv0s	103	39	hydrocarbon	hydrocarbon	NN
cord-314013-g091lv0s	103	40	receptor	receptor	NN
cord-314013-g091lv0s	103	41	IL-6	IL-6	NNP
cord-314013-g091lv0s	103	42	trans	trans	NNP
cord-314013-g091lv0s	103	43	-	-	NN
cord-314013-g091lv0s	103	44	signaling	signal	VBG
cord-314013-g091lv0s	103	45	via	via	IN
cord-314013-g091lv0s	103	46	the	the	DT
cord-314013-g091lv0s	103	47	soluble	soluble	JJ
cord-314013-g091lv0s	103	48	IL-6	IL-6	NNP
cord-314013-g091lv0s	103	49	receptor	receptor	NN
cord-314013-g091lv0s	103	50	:	:	:
cord-314013-g091lv0s	103	51	importance	importance	NN
cord-314013-g091lv0s	103	52	for	for	IN
cord-314013-g091lv0s	103	53	the	the	DT
cord-314013-g091lv0s	103	54	pro	pro	JJ
cord-314013-g091lv0s	103	55	-	-	JJ
cord-314013-g091lv0s	103	56	inflammatory	inflammatory	JJ
cord-314013-g091lv0s	103	57	activities	activity	NNS
cord-314013-g091lv0s	103	58	of	of	IN
cord-314013-g091lv0s	103	59	IL-6	IL-6	NNP
cord-314013-g091lv0s	103	60	Tocilizumab	Tocilizumab	NNP
cord-314013-g091lv0s	103	61	(	(	-LRB-
cord-314013-g091lv0s	103	62	Actemra	Actemra	NNP
cord-314013-g091lv0s	103	63	)	)	-RRB-
cord-314013-g091lv0s	103	64	.	.	.
cord-314013-g091lv0s	104	1	Hum	Hum	NNP
cord-314013-g091lv0s	104	2	.	.	.
cord-314013-g091lv0s	105	1	Vaccines	vaccine	NNS
cord-314013-g091lv0s	105	2	Immunotherapeut	Immunotherapeut	NNP
cord-314013-g091lv0s	105	3	Aryl	Aryl	NNP
cord-314013-g091lv0s	105	4	hydrocarbon	hydrocarbon	NN
cord-314013-g091lv0s	105	5	receptor	receptor	NN
cord-314013-g091lv0s	105	6	signals	signal	NNS
cord-314013-g091lv0s	105	7	attenuate	attenuate	VBP
cord-314013-g091lv0s	105	8	lung	lung	NN
cord-314013-g091lv0s	105	9	fibrosis	fibrosis	NN
cord-314013-g091lv0s	105	10	in	in	IN
cord-314013-g091lv0s	105	11	the	the	DT
cord-314013-g091lv0s	105	12	bleomycin	bleomycin	NN
cord-314013-g091lv0s	105	13	-	-	HYPH
cord-314013-g091lv0s	105	14	induced	induce	VBN
cord-314013-g091lv0s	105	15	mouse	mouse	NN
cord-314013-g091lv0s	105	16	model	model	NN
cord-314013-g091lv0s	105	17	for	for	IN
cord-314013-g091lv0s	105	18	pulmonary	pulmonary	JJ
cord-314013-g091lv0s	105	19	fibrosis	fibrosis	NN
cord-314013-g091lv0s	105	20	through	through	IN
cord-314013-g091lv0s	105	21	increase	increase	NN
cord-314013-g091lv0s	105	22	of	of	IN
cord-314013-g091lv0s	105	23	regulatory	regulatory	JJ
cord-314013-g091lv0s	105	24	T	t	NN
cord-314013-g091lv0s	105	25	cells	cell	NNS
cord-314013-g091lv0s	106	1	The	the	DT
cord-314013-g091lv0s	106	2	cytokine	cytokine	NN
cord-314013-g091lv0s	106	3	release	release	NN
cord-314013-g091lv0s	106	4	syndrome	syndrome	NN
cord-314013-g091lv0s	106	5	(	(	-LRB-
cord-314013-g091lv0s	106	6	CRS	CRS	NNP
cord-314013-g091lv0s	106	7	)	)	-RRB-
cord-314013-g091lv0s	106	8	of	of	IN
cord-314013-g091lv0s	106	9	severe	severe	JJ
cord-314013-g091lv0s	106	10	COVID-19	covid-19	NN
cord-314013-g091lv0s	106	11	and	and	CC
cord-314013-g091lv0s	106	12	Interleukin-6	Interleukin-6	NNP
cord-314013-g091lv0s	107	1	receptor	receptor	NN
cord-314013-g091lv0s	107	2	(	(	-LRB-
cord-314013-g091lv0s	107	3	IL-6R	IL-6R	NNP
cord-314013-g091lv0s	107	4	)	)	-RRB-
cord-314013-g091lv0s	107	5	antagonist	antagonist	NN
cord-314013-g091lv0s	108	1	Tocilizumab	Tocilizumab	NNP
cord-314013-g091lv0s	108	2	may	may	MD
cord-314013-g091lv0s	108	3	be	be	VB
cord-314013-g091lv0s	108	4	the	the	DT
cord-314013-g091lv0s	108	5	key	key	NN
cord-314013-g091lv0s	108	6	to	to	TO
cord-314013-g091lv0s	108	7	reduce	reduce	VB
cord-314013-g091lv0s	108	8	the	the	DT
cord-314013-g091lv0s	108	9	mortality	mortality	NN
cord-314013-g091lv0s	109	1	A	a	DT
cord-314013-g091lv0s	109	2	pneumonia	pneumonia	NN
cord-314013-g091lv0s	109	3	outbreak	outbreak	NN
cord-314013-g091lv0s	109	4	associated	associate	VBN
cord-314013-g091lv0s	109	5	with	with	IN
cord-314013-g091lv0s	109	6	a	a	DT
cord-314013-g091lv0s	109	7	new	new	JJ
cord-314013-g091lv0s	109	8	coronavirus	coronavirus	NN
cord-314013-g091lv0s	109	9	of	of	IN
cord-314013-g091lv0s	109	10	probable	probable	JJ
cord-314013-g091lv0s	109	11	bat	bat	NN
cord-314013-g091lv0s	109	12	origin	origin	NN
cord-314013-g091lv0s	110	1	The	the	DT
cord-314013-g091lv0s	110	2	authors	author	NNS
cord-314013-g091lv0s	110	3	would	would	MD
cord-314013-g091lv0s	110	4	like	like	VB
cord-314013-g091lv0s	110	5	to	to	TO
cord-314013-g091lv0s	110	6	thank	thank	VB
cord-314013-g091lv0s	110	7	P.	P.	NNP
cord-314013-g091lv0s	110	8	Puccetti	Puccetti	NNP
cord-314013-g091lv0s	110	9	for	for	IN
cord-314013-g091lv0s	110	10	revising	revise	VBG
cord-314013-g091lv0s	110	11	the	the	DT
cord-314013-g091lv0s	110	12	final	final	JJ
cord-314013-g091lv0s	110	13	draft	draft	NN
cord-314013-g091lv0s	110	14	of	of	IN
cord-314013-g091lv0s	110	15	the	the	DT
cord-314013-g091lv0s	110	16	manuscript	manuscript	NN
cord-314013-g091lv0s	110	17	.	.	.
cord-314013-g091lv0s	111	1	The	the	DT
cord-314013-g091lv0s	111	2	authors	author	NNS
cord-314013-g091lv0s	111	3	declare	declare	VBP
cord-314013-g091lv0s	111	4	that	that	IN
cord-314013-g091lv0s	111	5	the	the	DT
cord-314013-g091lv0s	111	6	research	research	NN
cord-314013-g091lv0s	111	7	was	be	VBD
cord-314013-g091lv0s	111	8	conducted	conduct	VBN
cord-314013-g091lv0s	111	9	in	in	IN
cord-314013-g091lv0s	111	10	the	the	DT
cord-314013-g091lv0s	111	11	absence	absence	NN
cord-314013-g091lv0s	111	12	of	of	IN
cord-314013-g091lv0s	111	13	any	any	DT
cord-314013-g091lv0s	111	14	commercial	commercial	JJ
cord-314013-g091lv0s	111	15	or	or	CC
cord-314013-g091lv0s	111	16	financial	financial	JJ
cord-314013-g091lv0s	111	17	relationships	relationship	NNS
cord-314013-g091lv0s	111	18	that	that	WDT
cord-314013-g091lv0s	111	19	could	could	MD
cord-314013-g091lv0s	111	20	be	be	VB
cord-314013-g091lv0s	111	21	construed	construe	VBN
cord-314013-g091lv0s	111	22	as	as	IN
cord-314013-g091lv0s	111	23	a	a	DT
cord-314013-g091lv0s	111	24	potential	potential	JJ
cord-314013-g091lv0s	111	25	conflict	conflict	NN
cord-314013-g091lv0s	111	26	of	of	IN
cord-314013-g091lv0s	111	27	interest	interest	NN
cord-314013-g091lv0s	111	28	.	.	.
cord-314013-g091lv0s	112	1	Copyright	copyright	NN
cord-314013-g091lv0s	112	2	©	©	NN
cord-314013-g091lv0s	112	3	2020	2020	CD
cord-314013-g091lv0s	112	4	Belladonna	Belladonna	NNP
cord-314013-g091lv0s	112	5	and	and	CC
cord-314013-g091lv0s	112	6	Orabona	Orabona	NNP
cord-314013-g091lv0s	112	7	.	.	.
cord-314013-g091lv0s	113	1	This	this	DT
cord-314013-g091lv0s	113	2	is	be	VBZ
cord-314013-g091lv0s	113	3	an	an	DT
cord-314013-g091lv0s	113	4	open	open	JJ
cord-314013-g091lv0s	113	5	-	-	HYPH
cord-314013-g091lv0s	113	6	access	access	NN
cord-314013-g091lv0s	113	7	article	article	NN
cord-314013-g091lv0s	113	8	distributed	distribute	VBN
cord-314013-g091lv0s	113	9	under	under	IN
cord-314013-g091lv0s	113	10	the	the	DT
cord-314013-g091lv0s	113	11	terms	term	NNS
cord-314013-g091lv0s	113	12	of	of	IN
cord-314013-g091lv0s	113	13	the	the	DT
cord-314013-g091lv0s	113	14	Creative	Creative	NNP
cord-314013-g091lv0s	113	15	Commons	Commons	NNP
cord-314013-g091lv0s	113	16	Attribution	Attribution	NNP
cord-314013-g091lv0s	113	17	License	License	NNP
cord-314013-g091lv0s	113	18	(	(	-LRB-
cord-314013-g091lv0s	113	19	CC	CC	NNP
cord-314013-g091lv0s	113	20	BY	BY	NNP
cord-314013-g091lv0s	113	21	)	)	-RRB-
cord-314013-g091lv0s	113	22	.	.	.
cord-314013-g091lv0s	114	1	The	the	DT
cord-314013-g091lv0s	114	2	use	use	NN
cord-314013-g091lv0s	114	3	,	,	,
cord-314013-g091lv0s	114	4	distribution	distribution	NN
cord-314013-g091lv0s	114	5	or	or	CC
cord-314013-g091lv0s	114	6	reproduction	reproduction	NN
cord-314013-g091lv0s	114	7	in	in	IN
cord-314013-g091lv0s	114	8	other	other	JJ
cord-314013-g091lv0s	114	9	forums	forum	NNS
cord-314013-g091lv0s	114	10	is	be	VBZ
cord-314013-g091lv0s	114	11	permitted	permit	VBN
cord-314013-g091lv0s	114	12	,	,	,
cord-314013-g091lv0s	114	13	provided	provide	VBD
cord-314013-g091lv0s	114	14	the	the	DT
cord-314013-g091lv0s	114	15	original	original	JJ
cord-314013-g091lv0s	114	16	author(s	author(s	NNP
cord-314013-g091lv0s	114	17	)	)	-RRB-
cord-314013-g091lv0s	114	18	and	and	CC
cord-314013-g091lv0s	114	19	the	the	DT
cord-314013-g091lv0s	114	20	copyright	copyright	NN
cord-314013-g091lv0s	114	21	owner(s	owner(s	NNP
cord-314013-g091lv0s	114	22	)	)	-RRB-
cord-314013-g091lv0s	114	23	are	be	VBP
cord-314013-g091lv0s	114	24	credited	credit	VBN
cord-314013-g091lv0s	114	25	and	and	CC
cord-314013-g091lv0s	114	26	that	that	IN
cord-314013-g091lv0s	114	27	the	the	DT
cord-314013-g091lv0s	114	28	original	original	JJ
cord-314013-g091lv0s	114	29	publication	publication	NN
cord-314013-g091lv0s	114	30	in	in	IN
cord-314013-g091lv0s	114	31	this	this	DT
cord-314013-g091lv0s	114	32	journal	journal	NN
cord-314013-g091lv0s	114	33	is	be	VBZ
cord-314013-g091lv0s	114	34	cited	cite	VBN
cord-314013-g091lv0s	114	35	,	,	,
cord-314013-g091lv0s	114	36	in	in	IN
cord-314013-g091lv0s	114	37	accordance	accordance	NN
cord-314013-g091lv0s	114	38	with	with	IN
cord-314013-g091lv0s	114	39	accepted	accepted	JJ
cord-314013-g091lv0s	114	40	academic	academic	JJ
cord-314013-g091lv0s	114	41	practice	practice	NN
cord-314013-g091lv0s	114	42	.	.	.
cord-314013-g091lv0s	115	1	No	no	DT
cord-314013-g091lv0s	115	2	use	use	NN
cord-314013-g091lv0s	115	3	,	,	,
cord-314013-g091lv0s	115	4	distribution	distribution	NN
cord-314013-g091lv0s	115	5	or	or	CC
cord-314013-g091lv0s	115	6	reproduction	reproduction	NN
cord-314013-g091lv0s	115	7	is	be	VBZ
cord-314013-g091lv0s	115	8	permitted	permit	VBN
cord-314013-g091lv0s	115	9	which	which	WDT
cord-314013-g091lv0s	115	10	does	do	VBZ
cord-314013-g091lv0s	115	11	not	not	RB
cord-314013-g091lv0s	115	12	comply	comply	VB
cord-314013-g091lv0s	115	13	with	with	IN
cord-314013-g091lv0s	115	14	these	these	DT
cord-314013-g091lv0s	115	15	terms	term	NNS
cord-314013-g091lv0s	115	16	.	.	.