id	sid	tid	token	lemma	pos
cord-311749-yp313biv	1	1	key	key	JJ
cord-311749-yp313biv	1	2	:	:	:
cord-311749-yp313biv	1	3	cord-311749-yp313biv	cord-311749-yp313biv	CD
cord-311749-yp313biv	1	4	authors	author	NNS
cord-311749-yp313biv	1	5	:	:	:
cord-311749-yp313biv	1	6	Chalmers	Chalmers	NNP
cord-311749-yp313biv	1	7	,	,	,
cord-311749-yp313biv	1	8	James	James	NNP
cord-311749-yp313biv	1	9	D.	D.	NNP
cord-311749-yp313biv	1	10	;	;	:
cord-311749-yp313biv	1	11	Chotirmall	Chotirmall	NNP
cord-311749-yp313biv	1	12	,	,	,
cord-311749-yp313biv	2	1	Sanjay	Sanjay	NNP
cord-311749-yp313biv	2	2	H.	H.	NNP
cord-311749-yp313biv	2	3	title	title	NN
cord-311749-yp313biv	2	4	:	:	:
cord-311749-yp313biv	2	5	Rewiring	Rewiring	NNP
cord-311749-yp313biv	2	6	the	the	DT
cord-311749-yp313biv	2	7	Immune	Immune	NNP
cord-311749-yp313biv	2	8	Response	Response	NNP
cord-311749-yp313biv	2	9	in	in	IN
cord-311749-yp313biv	2	10	COVID-19	COVID-19	NNP
cord-311749-yp313biv	2	11	date	date	NN
cord-311749-yp313biv	2	12	:	:	:
cord-311749-yp313biv	2	13	2020	2020	CD
cord-311749-yp313biv	2	14	-	-	HYPH
cord-311749-yp313biv	2	15	09	09	CD
cord-311749-yp313biv	2	16	-	-	SYM
cord-311749-yp313biv	2	17	15	15	CD
cord-311749-yp313biv	2	18	journal	journal	NN
cord-311749-yp313biv	2	19	:	:	:
cord-311749-yp313biv	3	1	Am	be	VBP
cord-311749-yp313biv	3	2	J	J	NNP
cord-311749-yp313biv	3	3	Respir	Respir	NNP
cord-311749-yp313biv	4	1	Crit	Crit	NNP
cord-311749-yp313biv	4	2	Care	Care	NNP
cord-311749-yp313biv	4	3	Med	Med	NNP
cord-311749-yp313biv	4	4	DOI	doi	NN
cord-311749-yp313biv	4	5	:	:	:
cord-311749-yp313biv	4	6	10.1164	10.1164	CD
cord-311749-yp313biv	4	7	/	/	SYM
cord-311749-yp313biv	4	8	rccm.202007	rccm.202007	NN
cord-311749-yp313biv	4	9	-	-	HYPH
cord-311749-yp313biv	4	10	2934ed	2934ed	NN
cord-311749-yp313biv	4	11	sha	sha	NNP
cord-311749-yp313biv	4	12	:	:	:
cord-311749-yp313biv	5	1	fdcc13118a9ea79dd40399d8b0c1cdf264732ac8	fdcc13118a9ea79dd40399d8b0c1cdf264732ac8	NFP
cord-311749-yp313biv	5	2	doc_id	doc_id	CD
cord-311749-yp313biv	5	3	:	:	:
cord-311749-yp313biv	5	4	311749	311749	CD
cord-311749-yp313biv	5	5	cord_uid	cord_uid	NNS
cord-311749-yp313biv	5	6	:	:	:
cord-311749-yp313biv	5	7	yp313biv	yp313biv	NN
cord-311749-yp313biv	5	8	nan	nan	NNP
cord-311749-yp313biv	5	9	paraseptal	paraseptal	JJ
cord-311749-yp313biv	5	10	emphysema	emphysema	NN
cord-311749-yp313biv	5	11	.	.	.
cord-311749-yp313biv	6	1	And	and	CC
cord-311749-yp313biv	6	2	although	although	IN
cord-311749-yp313biv	6	3	neutrophil	neutrophil	NN
cord-311749-yp313biv	6	4	elastase	elastase	NN
cord-311749-yp313biv	6	5	activity	activity	NN
cord-311749-yp313biv	6	6	was	be	VBD
cord-311749-yp313biv	6	7	not	not	RB
cord-311749-yp313biv	6	8	measured	measure	VBN
cord-311749-yp313biv	6	9	in	in	IN
cord-311749-yp313biv	6	10	this	this	DT
cord-311749-yp313biv	6	11	study	study	NN
cord-311749-yp313biv	6	12	,	,	,
cord-311749-yp313biv	6	13	it	-PRON-	PRP
cord-311749-yp313biv	6	14	might	may	MD
cord-311749-yp313biv	6	15	be	be	VB
cord-311749-yp313biv	6	16	speculated	speculate	VBN
cord-311749-yp313biv	6	17	that	that	IN
cord-311749-yp313biv	6	18	neutrophil	neutrophil	NN
cord-311749-yp313biv	6	19	elastase	elastase	NN
cord-311749-yp313biv	6	20	might	may	MD
cord-311749-yp313biv	6	21	be	be	VB
cord-311749-yp313biv	6	22	an	an	DT
cord-311749-yp313biv	6	23	important	important	JJ
cord-311749-yp313biv	6	24	driver	driver	NN
cord-311749-yp313biv	6	25	of	of	IN
cord-311749-yp313biv	6	26	paraseptal	paraseptal	JJ
cord-311749-yp313biv	6	27	emphysema	emphysema	NN
cord-311749-yp313biv	6	28	development	development	NN
cord-311749-yp313biv	6	29	.	.	.
cord-311749-yp313biv	7	1	A	a	DT
cord-311749-yp313biv	7	2	high	high	JJ
cord-311749-yp313biv	7	3	amount	amount	NN
cord-311749-yp313biv	7	4	of	of	IN
cord-311749-yp313biv	7	5	neutrophil	neutrophil	NN
cord-311749-yp313biv	7	6	elastase	elastase	NN
cord-311749-yp313biv	7	7	activity	activity	NN
cord-311749-yp313biv	7	8	has	have	VBZ
cord-311749-yp313biv	7	9	been	be	VBN
cord-311749-yp313biv	7	10	linked	link	VBN
cord-311749-yp313biv	7	11	to	to	IN
cord-311749-yp313biv	7	12	emphysema	emphysema	NN
cord-311749-yp313biv	7	13	in	in	IN
cord-311749-yp313biv	7	14	humans	human	NNS
cord-311749-yp313biv	7	15	and	and	CC
cord-311749-yp313biv	7	16	animals	animal	NNS
cord-311749-yp313biv	7	17	(	(	-LRB-
cord-311749-yp313biv	7	18	11	11	CD
cord-311749-yp313biv	7	19	)	)	-RRB-
cord-311749-yp313biv	7	20	.	.	.
cord-311749-yp313biv	8	1	Moreover	moreover	RB
cord-311749-yp313biv	8	2	,	,	,
cord-311749-yp313biv	8	3	increased	increase	VBN
cord-311749-yp313biv	8	4	elastase	elastase	NN
cord-311749-yp313biv	8	5	concentrations	concentration	NNS
cord-311749-yp313biv	8	6	in	in	IN
cord-311749-yp313biv	8	7	sputum	sputum	NN
cord-311749-yp313biv	8	8	are	be	VBP
cord-311749-yp313biv	8	9	associated	associate	VBN
cord-311749-yp313biv	8	10	with	with	IN
cord-311749-yp313biv	8	11	increased	increase	VBN
cord-311749-yp313biv	8	12	risk	risk	NN
cord-311749-yp313biv	8	13	of	of	IN
cord-311749-yp313biv	8	14	exacerbations	exacerbation	NNS
cord-311749-yp313biv	8	15	(	(	-LRB-
cord-311749-yp313biv	8	16	12	12	CD
cord-311749-yp313biv	8	17	)	)	-RRB-
cord-311749-yp313biv	8	18	,	,	,
cord-311749-yp313biv	8	19	suggesting	suggest	VBG
cord-311749-yp313biv	8	20	that	that	IN
cord-311749-yp313biv	8	21	further	further	JJ
cord-311749-yp313biv	8	22	understanding	understanding	NN
cord-311749-yp313biv	8	23	of	of	IN
cord-311749-yp313biv	8	24	the	the	DT
cord-311749-yp313biv	8	25	cellular	cellular	JJ
cord-311749-yp313biv	8	26	and	and	CC
cord-311749-yp313biv	8	27	molecular	molecular	JJ
cord-311749-yp313biv	8	28	orchestration	orchestration	NN
cord-311749-yp313biv	8	29	leading	lead	VBG
cord-311749-yp313biv	8	30	to	to	IN
cord-311749-yp313biv	8	31	emphysema	emphysema	NN
cord-311749-yp313biv	8	32	might	may	MD
cord-311749-yp313biv	8	33	give	give	VB
cord-311749-yp313biv	8	34	insight	insight	NN
cord-311749-yp313biv	8	35	that	that	WDT
cord-311749-yp313biv	8	36	ultimately	ultimately	RB
cord-311749-yp313biv	8	37	will	will	MD
cord-311749-yp313biv	8	38	translate	translate	VB
cord-311749-yp313biv	8	39	to	to	IN
cord-311749-yp313biv	8	40	modifying	modify	VBG
cord-311749-yp313biv	8	41	therapies	therapy	NNS
cord-311749-yp313biv	8	42	for	for	IN
cord-311749-yp313biv	8	43	many	many	JJ
cord-311749-yp313biv	8	44	people	people	NNS
cord-311749-yp313biv	8	45	suffering	suffer	VBG
cord-311749-yp313biv	8	46	from	from	IN
cord-311749-yp313biv	8	47	COPD	COPD	NNP
cord-311749-yp313biv	8	48	.	.	.
cord-311749-yp313biv	9	1	A	a	DT
cord-311749-yp313biv	9	2	question	question	NN
cord-311749-yp313biv	9	3	that	that	WDT
cord-311749-yp313biv	9	4	arises	arise	VBZ
cord-311749-yp313biv	9	5	from	from	IN
cord-311749-yp313biv	9	6	this	this	DT
cord-311749-yp313biv	9	7	work	work	NN
cord-311749-yp313biv	9	8	is	be	VBZ
cord-311749-yp313biv	9	9	how	how	WRB
cord-311749-yp313biv	9	10	paraseptal	paraseptal	JJ
cord-311749-yp313biv	9	11	emphysema	emphysema	NN
cord-311749-yp313biv	9	12	develops	develop	VBZ
cord-311749-yp313biv	9	13	.	.	.
cord-311749-yp313biv	10	1	The	the	DT
cord-311749-yp313biv	10	2	current	current	JJ
cord-311749-yp313biv	10	3	notion	notion	NN
cord-311749-yp313biv	10	4	for	for	IN
cord-311749-yp313biv	10	5	the	the	DT
cord-311749-yp313biv	10	6	pathologic	pathologic	JJ
cord-311749-yp313biv	10	7	sequence	sequence	NN
cord-311749-yp313biv	10	8	of	of	IN
cord-311749-yp313biv	10	9	events	event	NNS
cord-311749-yp313biv	10	10	from	from	IN
cord-311749-yp313biv	10	11	cigarette	cigarette	NN
cord-311749-yp313biv	10	12	smoke	smoke	NN
cord-311749-yp313biv	10	13	to	to	IN
cord-311749-yp313biv	10	14	centrilobular	centrilobular	NNP
cord-311749-yp313biv	10	15	emphysema	emphysema	NN
cord-311749-yp313biv	10	16	development	development	NN
cord-311749-yp313biv	10	17	starts	start	VBZ
cord-311749-yp313biv	10	18	with	with	IN
cord-311749-yp313biv	10	19	the	the	DT
cord-311749-yp313biv	10	20	inflammation	inflammation	NN
cord-311749-yp313biv	10	21	of	of	IN
cord-311749-yp313biv	10	22	small	small	JJ
cord-311749-yp313biv	10	23	airway	airway	NN
cord-311749-yp313biv	10	24	walls	wall	NNS
cord-311749-yp313biv	10	25	occurring	occur	VBG
cord-311749-yp313biv	10	26	in	in	IN
cord-311749-yp313biv	10	27	the	the	DT
cord-311749-yp313biv	10	28	center	center	NN
cord-311749-yp313biv	10	29	of	of	IN
cord-311749-yp313biv	10	30	the	the	DT
cord-311749-yp313biv	10	31	lobule	lobule	NN
cord-311749-yp313biv	10	32	.	.	.
cord-311749-yp313biv	11	1	This	this	DT
cord-311749-yp313biv	11	2	process	process	NN
cord-311749-yp313biv	11	3	leads	lead	VBZ
cord-311749-yp313biv	11	4	to	to	IN
cord-311749-yp313biv	11	5	bronchiolar	bronchiolar	JJ
cord-311749-yp313biv	11	6	-	-	HYPH
cord-311749-yp313biv	11	7	alveolar	alveolar	NN
cord-311749-yp313biv	11	8	attachments	attachment	NNS
cord-311749-yp313biv	11	9	and	and	CC
cord-311749-yp313biv	11	10	surrounding	surround	VBG
cord-311749-yp313biv	11	11	alveolar	alveolar	JJ
cord-311749-yp313biv	11	12	wall	wall	NN
cord-311749-yp313biv	11	13	destruction	destruction	NN
cord-311749-yp313biv	11	14	.	.	.
cord-311749-yp313biv	12	1	Because	because	IN
cord-311749-yp313biv	12	2	paraseptal	paraseptal	JJ
cord-311749-yp313biv	12	3	emphysema	emphysema	NN
cord-311749-yp313biv	12	4	occurs	occur	VBZ
cord-311749-yp313biv	12	5	adjacent	adjacent	JJ
cord-311749-yp313biv	12	6	to	to	IN
cord-311749-yp313biv	12	7	the	the	DT
cord-311749-yp313biv	12	8	pleura	pleura	NN
cord-311749-yp313biv	12	9	and	and	CC
cord-311749-yp313biv	12	10	septa	septa	NN
cord-311749-yp313biv	12	11	and	and	CC
cord-311749-yp313biv	12	12	emphysema	emphysema	NN
cord-311749-yp313biv	12	13	animal	animal	NN
cord-311749-yp313biv	12	14	models	model	NNS
cord-311749-yp313biv	12	15	have	have	VBP
cord-311749-yp313biv	12	16	marked	mark	VBN
cord-311749-yp313biv	12	17	changes	change	NNS
cord-311749-yp313biv	12	18	in	in	IN
cord-311749-yp313biv	12	19	capillary	capillary	JJ
cord-311749-yp313biv	12	20	segments	segment	NNS
cord-311749-yp313biv	12	21	(	(	-LRB-
cord-311749-yp313biv	12	22	i.e.	i.e.	FW
cord-311749-yp313biv	12	23	,	,	,
cord-311749-yp313biv	12	24	a	a	DT
cord-311749-yp313biv	12	25	higher	high	JJR
cord-311749-yp313biv	12	26	number	number	NN
cord-311749-yp313biv	12	27	of	of	IN
cord-311749-yp313biv	12	28	nonconnecting	nonconnecting	JJ
cord-311749-yp313biv	12	29	segments	segment	NNS
cord-311749-yp313biv	12	30	)	)	-RRB-
cord-311749-yp313biv	12	31	on	on	IN
cord-311749-yp313biv	12	32	the	the	DT
cord-311749-yp313biv	12	33	pleural	pleural	JJ
cord-311749-yp313biv	12	34	surface	surface	NN
cord-311749-yp313biv	12	35	(	(	-LRB-
cord-311749-yp313biv	12	36	13	13	CD
cord-311749-yp313biv	12	37	)	)	-RRB-
cord-311749-yp313biv	12	38	,	,	,
cord-311749-yp313biv	12	39	disruptions	disruption	NNS
cord-311749-yp313biv	12	40	of	of	IN
cord-311749-yp313biv	12	41	pulmonary	pulmonary	JJ
cord-311749-yp313biv	12	42	and/or	and/or	CC
cord-311749-yp313biv	12	43	pleural	pleural	JJ
cord-311749-yp313biv	12	44	capillaries	capillary	NNS
cord-311749-yp313biv	12	45	might	may	MD
cord-311749-yp313biv	12	46	also	also	RB
cord-311749-yp313biv	12	47	contribute	contribute	VB
cord-311749-yp313biv	12	48	to	to	IN
cord-311749-yp313biv	12	49	paraseptal	paraseptal	JJ
cord-311749-yp313biv	12	50	emphysema	emphysema	NN
cord-311749-yp313biv	12	51	.	.	.
cord-311749-yp313biv	13	1	It	-PRON-	PRP
cord-311749-yp313biv	13	2	can	can	MD
cord-311749-yp313biv	13	3	be	be	VB
cord-311749-yp313biv	13	4	speculated	speculate	VBN
cord-311749-yp313biv	13	5	that	that	IN
cord-311749-yp313biv	13	6	pulmonary	pulmonary	JJ
cord-311749-yp313biv	13	7	perfusion	perfusion	NN
cord-311749-yp313biv	13	8	deficiency	deficiency	NN
cord-311749-yp313biv	13	9	may	may	MD
cord-311749-yp313biv	13	10	lead	lead	VB
cord-311749-yp313biv	13	11	to	to	IN
cord-311749-yp313biv	13	12	misbalanced	misbalance	VBN
cord-311749-yp313biv	13	13	inflammatory	inflammatory	JJ
cord-311749-yp313biv	13	14	response	response	NN
cord-311749-yp313biv	13	15	and	and	CC
cord-311749-yp313biv	13	16	tissue	tissue	NN
cord-311749-yp313biv	13	17	damage	damage	NN
cord-311749-yp313biv	13	18	repair	repair	NN
cord-311749-yp313biv	13	19	,	,	,
cord-311749-yp313biv	13	20	resulting	result	VBG
cord-311749-yp313biv	13	21	in	in	IN
cord-311749-yp313biv	13	22	paraseptal	paraseptal	JJ
cord-311749-yp313biv	13	23	emphysema	emphysema	NN
cord-311749-yp313biv	13	24	.	.	.
cord-311749-yp313biv	14	1	In	in	IN
cord-311749-yp313biv	14	2	conclusion	conclusion	NN
cord-311749-yp313biv	14	3	,	,	,
cord-311749-yp313biv	14	4	the	the	DT
cord-311749-yp313biv	14	5	authors	author	NNS
cord-311749-yp313biv	14	6	should	should	MD
cord-311749-yp313biv	14	7	be	be	VB
cord-311749-yp313biv	14	8	commended	commend	VBN
cord-311749-yp313biv	14	9	for	for	IN
cord-311749-yp313biv	14	10	this	this	DT
cord-311749-yp313biv	14	11	elegant	elegant	JJ
cord-311749-yp313biv	14	12	contribution	contribution	NN
cord-311749-yp313biv	14	13	to	to	IN
cord-311749-yp313biv	14	14	pathologic	pathologic	JJ
cord-311749-yp313biv	14	15	differences	difference	NNS
cord-311749-yp313biv	14	16	in	in	IN
cord-311749-yp313biv	14	17	the	the	DT
cord-311749-yp313biv	14	18	small	small	JJ
cord-311749-yp313biv	14	19	airways	airway	NNS
cord-311749-yp313biv	14	20	and	and	CC
cord-311749-yp313biv	14	21	cellular	cellular	JJ
cord-311749-yp313biv	14	22	composition	composition	NN
cord-311749-yp313biv	14	23	between	between	IN
cord-311749-yp313biv	14	24	paraseptal	paraseptal	NNP
cord-311749-yp313biv	14	25	and	and	CC
cord-311749-yp313biv	14	26	centrilobular	centrilobular	NNP
cord-311749-yp313biv	14	27	emphysema	emphysema	NN
cord-311749-yp313biv	14	28	.	.	.
cord-311749-yp313biv	15	1	After	after	IN
cord-311749-yp313biv	15	2	a	a	DT
cord-311749-yp313biv	15	3	long	long	JJ
cord-311749-yp313biv	15	4	time	time	NN
cord-311749-yp313biv	15	5	,	,	,
cord-311749-yp313biv	15	6	this	this	DT
cord-311749-yp313biv	15	7	work	work	NN
cord-311749-yp313biv	15	8	brings	bring	VBZ
cord-311749-yp313biv	15	9	paraseptal	paraseptal	JJ
cord-311749-yp313biv	15	10	emphysema	emphysema	NN
cord-311749-yp313biv	15	11	to	to	IN
cord-311749-yp313biv	15	12	the	the	DT
cord-311749-yp313biv	15	13	center	center	NN
cord-311749-yp313biv	15	14	of	of	IN
cord-311749-yp313biv	15	15	the	the	DT
cord-311749-yp313biv	15	16	stage	stage	NN
cord-311749-yp313biv	15	17	.	.	.
cord-311749-yp313biv	16	1	n	n	CC
cord-311749-yp313biv	16	2	Copyright	copyright	NN
cord-311749-yp313biv	17	1	©	©	NN
cord-311749-yp313biv	17	2	2020	2020	CD
cord-311749-yp313biv	17	3	by	by	IN
cord-311749-yp313biv	17	4	the	the	DT
cord-311749-yp313biv	17	5	American	American	NNP
cord-311749-yp313biv	17	6	Thoracic	Thoracic	NNP
cord-311749-yp313biv	17	7	Society	Society	NNP
cord-311749-yp313biv	18	1	At	at	IN
cord-311749-yp313biv	18	2	the	the	DT
cord-311749-yp313biv	18	3	time	time	NN
cord-311749-yp313biv	18	4	of	of	IN
cord-311749-yp313biv	18	5	writing	writing	NN
cord-311749-yp313biv	18	6	,	,	,
cord-311749-yp313biv	18	7	the	the	DT
cord-311749-yp313biv	18	8	severe	severe	JJ
cord-311749-yp313biv	18	9	acute	acute	JJ
cord-311749-yp313biv	18	10	respiratory	respiratory	JJ
cord-311749-yp313biv	18	11	syndrome	syndrome	NN
cord-311749-yp313biv	18	12	coronavirus	coronavirus	NN
cord-311749-yp313biv	18	13	2	2	CD
cord-311749-yp313biv	19	1	(	(	-LRB-
cord-311749-yp313biv	19	2	SARS	SARS	NNP
cord-311749-yp313biv	19	3	-	-	HYPH
cord-311749-yp313biv	19	4	CoV-2	CoV-2	NNP
cord-311749-yp313biv	19	5	)	)	-RRB-
cord-311749-yp313biv	19	6	pandemic	pandemic	NN
cord-311749-yp313biv	19	7	continues	continue	VBZ
cord-311749-yp313biv	19	8	globally	globally	RB
cord-311749-yp313biv	19	9	,	,	,
cord-311749-yp313biv	19	10	with	with	IN
cord-311749-yp313biv	19	11	nearly	nearly	RB
cord-311749-yp313biv	19	12	15	15	CD
cord-311749-yp313biv	19	13	million	million	CD
cord-311749-yp313biv	19	14	documented	document	VBN
cord-311749-yp313biv	19	15	cases	case	NNS
cord-311749-yp313biv	19	16	and	and	CC
cord-311749-yp313biv	19	17	more	more	JJR
cord-311749-yp313biv	19	18	than	than	IN
cord-311749-yp313biv	19	19	600,000	600,000	CD
cord-311749-yp313biv	19	20	deaths	death	NNS
cord-311749-yp313biv	19	21	worldwide	worldwide	RB
cord-311749-yp313biv	19	22	(	(	-LRB-
cord-311749-yp313biv	19	23	1	1	CD
cord-311749-yp313biv	19	24	)	)	-RRB-
cord-311749-yp313biv	19	25	.	.	.
cord-311749-yp313biv	20	1	Many	many	JJ
cord-311749-yp313biv	20	2	countries	country	NNS
cord-311749-yp313biv	20	3	have	have	VBP
cord-311749-yp313biv	20	4	recently	recently	RB
cord-311749-yp313biv	20	5	seen	see	VBN
cord-311749-yp313biv	20	6	falls	fall	VBZ
cord-311749-yp313biv	20	7	in	in	IN
cord-311749-yp313biv	20	8	the	the	DT
cord-311749-yp313biv	20	9	number	number	NN
cord-311749-yp313biv	20	10	of	of	IN
cord-311749-yp313biv	20	11	confirmed	confirm	VBN
cord-311749-yp313biv	20	12	cases	case	NNS
cord-311749-yp313biv	20	13	and	and	CC
cord-311749-yp313biv	20	14	are	be	VBP
cord-311749-yp313biv	20	15	beginning	begin	VBG
cord-311749-yp313biv	20	16	to	to	TO
cord-311749-yp313biv	20	17	cautiously	cautiously	RB
cord-311749-yp313biv	20	18	reopen	reopen	VB
cord-311749-yp313biv	20	19	following	follow	VBG
cord-311749-yp313biv	20	20	lockdown	lockdown	NN
cord-311749-yp313biv	20	21	measures	measure	NNS
cord-311749-yp313biv	20	22	,	,	,
cord-311749-yp313biv	20	23	whereas	whereas	IN
cord-311749-yp313biv	20	24	others	other	NNS
cord-311749-yp313biv	20	25	are	be	VBP
cord-311749-yp313biv	20	26	experiencing	experience	VBG
cord-311749-yp313biv	20	27	a	a	DT
cord-311749-yp313biv	20	28	continued	continued	JJ
cord-311749-yp313biv	20	29	increase	increase	NN
cord-311749-yp313biv	20	30	,	,	,
cord-311749-yp313biv	20	31	"	"	``
cord-311749-yp313biv	20	32	second	second	JJ
cord-311749-yp313biv	20	33	waves	wave	NNS
cord-311749-yp313biv	20	34	"	"	''
cord-311749-yp313biv	20	35	of	of	IN
cord-311749-yp313biv	20	36	infection	infection	NN
cord-311749-yp313biv	20	37	,	,	,
cord-311749-yp313biv	20	38	or	or	CC
cord-311749-yp313biv	20	39	localized	localize	VBN
cord-311749-yp313biv	20	40	outbreaks	outbreak	NNS
cord-311749-yp313biv	20	41	following	follow	VBG
cord-311749-yp313biv	20	42	an	an	DT
cord-311749-yp313biv	20	43	initial	initial	JJ
cord-311749-yp313biv	20	44	reduction	reduction	NN
cord-311749-yp313biv	20	45	in	in	IN
cord-311749-yp313biv	20	46	cases	case	NNS
cord-311749-yp313biv	20	47	(	(	-LRB-
cord-311749-yp313biv	20	48	2	2	CD
cord-311749-yp313biv	20	49	,	,	,
cord-311749-yp313biv	20	50	3	3	CD
cord-311749-yp313biv	20	51	)	)	-RRB-
cord-311749-yp313biv	20	52	.	.	.
cord-311749-yp313biv	21	1	This	this	DT
cord-311749-yp313biv	21	2	pandemic	pandemic	NN
cord-311749-yp313biv	21	3	represents	represent	VBZ
cord-311749-yp313biv	21	4	the	the	DT
cord-311749-yp313biv	21	5	greatest	great	JJS
cord-311749-yp313biv	21	6	public	public	JJ
cord-311749-yp313biv	21	7	health	health	NN
cord-311749-yp313biv	21	8	,	,	,
cord-311749-yp313biv	21	9	clinical	clinical	JJ
cord-311749-yp313biv	21	10	,	,	,
cord-311749-yp313biv	21	11	and	and	CC
cord-311749-yp313biv	21	12	scientific	scientific	JJ
cord-311749-yp313biv	21	13	challenge	challenge	NN
cord-311749-yp313biv	21	14	of	of	IN
cord-311749-yp313biv	21	15	our	-PRON-	PRP$
cord-311749-yp313biv	21	16	generation	generation	NN
cord-311749-yp313biv	21	17	.	.	.
cord-311749-yp313biv	22	1	Containing	contain	VBG
cord-311749-yp313biv	22	2	viral	viral	JJ
cord-311749-yp313biv	22	3	spread	spread	NN
cord-311749-yp313biv	22	4	has	have	VBZ
cord-311749-yp313biv	22	5	necessitated	necessitate	VBN
cord-311749-yp313biv	22	6	unprecedented	unprecedented	JJ
cord-311749-yp313biv	22	7	social	social	JJ
cord-311749-yp313biv	22	8	and	and	CC
cord-311749-yp313biv	22	9	economic	economic	JJ
cord-311749-yp313biv	22	10	change	change	NN
cord-311749-yp313biv	22	11	as	as	IN
cord-311749-yp313biv	22	12	lockdowns	lockdown	NNS
cord-311749-yp313biv	22	13	only	only	RB
cord-311749-yp313biv	22	14	"	"	``
cord-311749-yp313biv	22	15	temporarily	temporarily	RB
cord-311749-yp313biv	22	16	"	"	''
cord-311749-yp313biv	22	17	limit	limit	VBP
cord-311749-yp313biv	22	18	morbidity	morbidity	NN
cord-311749-yp313biv	22	19	and	and	CC
cord-311749-yp313biv	22	20	mortality	mortality	NN
cord-311749-yp313biv	22	21	.	.	.
cord-311749-yp313biv	23	1	Identifying	identify	VBG
cord-311749-yp313biv	23	2	effective	effective	JJ
cord-311749-yp313biv	23	3	therapies	therapy	NNS
cord-311749-yp313biv	23	4	and/or	and/or	CC
cord-311749-yp313biv	23	5	a	a	DT
cord-311749-yp313biv	23	6	vaccine	vaccine	NN
cord-311749-yp313biv	23	7	remain	remain	VBP
cord-311749-yp313biv	23	8	our	-PRON-	PRP$
cord-311749-yp313biv	23	9	only	only	JJ
cord-311749-yp313biv	23	10	long	long	JJ
cord-311749-yp313biv	23	11	-	-	HYPH
cord-311749-yp313biv	23	12	term	term	NN
cord-311749-yp313biv	23	13	solutions	solution	NNS
cord-311749-yp313biv	23	14	.	.	.
cord-311749-yp313biv	24	1	Simply	simply	RB
cord-311749-yp313biv	24	2	put	put	VBN
cord-311749-yp313biv	24	3	,	,	,
cord-311749-yp313biv	24	4	research	research	NN
cord-311749-yp313biv	24	5	is	be	VBZ
cord-311749-yp313biv	24	6	the	the	DT
cord-311749-yp313biv	24	7	only	only	JJ
cord-311749-yp313biv	24	8	exit	exit	NN
cord-311749-yp313biv	24	9	strategy	strategy	NN
cord-311749-yp313biv	24	10	(	(	-LRB-
cord-311749-yp313biv	24	11	2	2	CD
cord-311749-yp313biv	24	12	)	)	-RRB-
cord-311749-yp313biv	24	13	(	(	-LRB-
cord-311749-yp313biv	24	14	3	3	LS
cord-311749-yp313biv	24	15	)	)	-RRB-
cord-311749-yp313biv	24	16	(	(	-LRB-
cord-311749-yp313biv	24	17	4	4	LS
cord-311749-yp313biv	24	18	)	)	-RRB-
cord-311749-yp313biv	24	19	(	(	-LRB-
cord-311749-yp313biv	24	20	5	5	CD
cord-311749-yp313biv	24	21	)	)	-RRB-
cord-311749-yp313biv	24	22	.	.	.
cord-311749-yp313biv	25	1	Great	great	JJ
cord-311749-yp313biv	25	2	progress	progress	NN
cord-311749-yp313biv	25	3	has	have	VBZ
cord-311749-yp313biv	25	4	been	be	VBN
cord-311749-yp313biv	25	5	made	make	VBN
cord-311749-yp313biv	25	6	in	in	IN
cord-311749-yp313biv	25	7	understanding	understand	VBG
cord-311749-yp313biv	25	8	the	the	DT
cord-311749-yp313biv	25	9	pathophysiology	pathophysiology	NN
cord-311749-yp313biv	25	10	of	of	IN
cord-311749-yp313biv	25	11	coronavirus	coronavirus	NN
cord-311749-yp313biv	25	12	disease	disease	NN
cord-311749-yp313biv	25	13	(	(	-LRB-
cord-311749-yp313biv	25	14	COVID-19	COVID-19	NNP
cord-311749-yp313biv	25	15	)	)	-RRB-
cord-311749-yp313biv	25	16	,	,	,
cord-311749-yp313biv	25	17	the	the	DT
cord-311749-yp313biv	25	18	disease	disease	NN
cord-311749-yp313biv	25	19	caused	cause	VBN
cord-311749-yp313biv	25	20	by	by	IN
cord-311749-yp313biv	25	21	infection	infection	NN
cord-311749-yp313biv	25	22	with	with	IN
cord-311749-yp313biv	25	23	SARS	SARS	NNP
cord-311749-yp313biv	25	24	-	-	HYPH
cord-311749-yp313biv	25	25	CoV-2	CoV-2	NNP
cord-311749-yp313biv	25	26	.	.	.
cord-311749-yp313biv	26	1	Current	current	JJ
cord-311749-yp313biv	26	2	concepts	concept	NNS
cord-311749-yp313biv	26	3	regard	regard	VBP
cord-311749-yp313biv	26	4	COVID-19	COVID-19	NNP
cord-311749-yp313biv	26	5	as	as	IN
cord-311749-yp313biv	26	6	a	a	DT
cord-311749-yp313biv	26	7	biphasic	biphasic	JJ
cord-311749-yp313biv	26	8	illness	illness	NN
cord-311749-yp313biv	26	9	:	:	:
cord-311749-yp313biv	26	10	an	an	DT
cord-311749-yp313biv	26	11	initial	initial	JJ
cord-311749-yp313biv	26	12	viral	viral	JJ
cord-311749-yp313biv	26	13	phase	phase	NN
cord-311749-yp313biv	26	14	with	with	IN
cord-311749-yp313biv	26	15	suggested	suggest	VBN
cord-311749-yp313biv	26	16	mean	mean	JJ
cord-311749-yp313biv	26	17	duration	duration	NN
cord-311749-yp313biv	26	18	of	of	IN
cord-311749-yp313biv	26	19	7	7	CD
cord-311749-yp313biv	26	20	days	day	NNS
cord-311749-yp313biv	26	21	followed	follow	VBN
cord-311749-yp313biv	26	22	by	by	IN
cord-311749-yp313biv	26	23	a	a	DT
cord-311749-yp313biv	26	24	"	"	``
cord-311749-yp313biv	26	25	hyperinflammatory	hyperinflammatory	NN
cord-311749-yp313biv	26	26	phase	phase	NN
cord-311749-yp313biv	26	27	"	"	''
cord-311749-yp313biv	26	28	characterized	characterize	VBN
cord-311749-yp313biv	26	29	by	by	IN
cord-311749-yp313biv	26	30	host	host	NN
cord-311749-yp313biv	26	31	-	-	HYPH
cord-311749-yp313biv	26	32	mediated	mediate	VBN
cord-311749-yp313biv	26	33	organ	organ	NN
cord-311749-yp313biv	26	34	damage	damage	NN
cord-311749-yp313biv	26	35	and	and	CC
cord-311749-yp313biv	26	36	what	what	WP
cord-311749-yp313biv	26	37	is	be	VBZ
cord-311749-yp313biv	26	38	widely	widely	RB
cord-311749-yp313biv	26	39	referred	refer	VBN
cord-311749-yp313biv	26	40	to	to	IN
cord-311749-yp313biv	26	41	as	as	IN
cord-311749-yp313biv	26	42	a	a	DT
cord-311749-yp313biv	26	43	"	"	``
cord-311749-yp313biv	26	44	cytokine	cytokine	NN
cord-311749-yp313biv	26	45	storm	storm	NN
cord-311749-yp313biv	26	46	"	"	''
cord-311749-yp313biv	26	47	(	(	-LRB-
cord-311749-yp313biv	26	48	6	6	CD
cord-311749-yp313biv	26	49	)	)	-RRB-
cord-311749-yp313biv	26	50	.	.	.
cord-311749-yp313biv	27	1	A	a	DT
cord-311749-yp313biv	27	2	subset	subset	NN
cord-311749-yp313biv	27	3	of	of	IN
cord-311749-yp313biv	27	4	patients	patient	NNS
cord-311749-yp313biv	27	5	with	with	IN
cord-311749-yp313biv	27	6	COVID-19	covid-19	JJ
cord-311749-yp313biv	27	7	display	display	NN
cord-311749-yp313biv	27	8	features	feature	VBZ
cord-311749-yp313biv	27	9	consistent	consistent	JJ
cord-311749-yp313biv	27	10	with	with	IN
cord-311749-yp313biv	27	11	hemophagocytic	hemophagocytic	JJ
cord-311749-yp313biv	27	12	lymphohistiocytosis	lymphohistiocytosis	NNP
cord-311749-yp313biv	27	13	(	(	-LRB-
cord-311749-yp313biv	27	14	HLH	HLH	NNP
cord-311749-yp313biv	27	15	)	)	-RRB-
cord-311749-yp313biv	27	16	,	,	,
cord-311749-yp313biv	27	17	a	a	DT
cord-311749-yp313biv	27	18	fulminant	fulminant	JJ
cord-311749-yp313biv	27	19	hypercytokinemic	hypercytokinemic	NN
cord-311749-yp313biv	27	20	syndrome	syndrome	NN
cord-311749-yp313biv	27	21	associated	associate	VBN
cord-311749-yp313biv	27	22	with	with	IN
cord-311749-yp313biv	27	23	multiorgan	multiorgan	NNP
cord-311749-yp313biv	27	24	failure	failure	NN
cord-311749-yp313biv	27	25	,	,	,
cord-311749-yp313biv	27	26	cytopenias	cytopenias	NNP
cord-311749-yp313biv	27	27	,	,	,
cord-311749-yp313biv	27	28	and	and	CC
cord-311749-yp313biv	27	29	abnormal	abnormal	JJ
cord-311749-yp313biv	27	30	liver	liver	NN
cord-311749-yp313biv	27	31	function	function	NN
cord-311749-yp313biv	27	32	tests	test	NNS
cord-311749-yp313biv	27	33	(	(	-LRB-
cord-311749-yp313biv	27	34	7	7	CD
cord-311749-yp313biv	27	35	)	)	-RRB-
cord-311749-yp313biv	27	36	.	.	.
cord-311749-yp313biv	28	1	There	there	EX
cord-311749-yp313biv	28	2	are	be	VBP
cord-311749-yp313biv	28	3	,	,	,
cord-311749-yp313biv	28	4	however	however	RB
cord-311749-yp313biv	28	5	,	,	,
cord-311749-yp313biv	28	6	important	important	JJ
cord-311749-yp313biv	28	7	differences	difference	NNS
cord-311749-yp313biv	28	8	in	in	IN
cord-311749-yp313biv	28	9	the	the	DT
cord-311749-yp313biv	28	10	inflammatory	inflammatory	JJ
cord-311749-yp313biv	28	11	profile	profile	NN
cord-311749-yp313biv	28	12	of	of	IN
cord-311749-yp313biv	28	13	HLH	HLH	NNP
cord-311749-yp313biv	28	14	and	and	CC
cord-311749-yp313biv	28	15	severe	severe	JJ
cord-311749-yp313biv	28	16	COVID-19	COVID-19	NNP
cord-311749-yp313biv	28	17	,	,	,
cord-311749-yp313biv	28	18	suggesting	suggest	VBG
cord-311749-yp313biv	28	19	a	a	DT
cord-311749-yp313biv	28	20	distinct	distinct	JJ
cord-311749-yp313biv	28	21	pathophysiology	pathophysiology	NN
cord-311749-yp313biv	28	22	.	.	.
cord-311749-yp313biv	29	1	The	the	DT
cord-311749-yp313biv	29	2	respiratory	respiratory	JJ
cord-311749-yp313biv	29	3	manifestation	manifestation	NN
cord-311749-yp313biv	29	4	of	of	IN
cord-311749-yp313biv	29	5	this	this	DT
cord-311749-yp313biv	29	6	systemic	systemic	JJ
cord-311749-yp313biv	29	7	inflammatory	inflammatory	JJ
cord-311749-yp313biv	29	8	response	response	NN
cord-311749-yp313biv	29	9	is	be	VBZ
cord-311749-yp313biv	29	10	acute	acute	JJ
cord-311749-yp313biv	29	11	respiratory	respiratory	JJ
cord-311749-yp313biv	29	12	distress	distress	NN
cord-311749-yp313biv	29	13	syndrome	syndrome	NN
cord-311749-yp313biv	29	14	(	(	-LRB-
cord-311749-yp313biv	29	15	ARDS	ARDS	NNP
cord-311749-yp313biv	29	16	)	)	-RRB-
cord-311749-yp313biv	29	17	,	,	,
cord-311749-yp313biv	29	18	and	and	CC
cord-311749-yp313biv	29	19	approximately	approximately	RB
cord-311749-yp313biv	29	20	30	30	CD
cord-311749-yp313biv	29	21	%	%	NN
cord-311749-yp313biv	29	22	of	of	IN
cord-311749-yp313biv	29	23	patients	patient	NNS
cord-311749-yp313biv	29	24	with	with	IN
cord-311749-yp313biv	29	25	COVID-19	COVID-19	NNP
cord-311749-yp313biv	29	26	from	from	IN
cord-311749-yp313biv	29	27	the	the	DT
cord-311749-yp313biv	29	28	initial	initial	JJ
cord-311749-yp313biv	29	29	series	series	NN
cord-311749-yp313biv	29	30	in	in	IN
cord-311749-yp313biv	29	31	Wuhan	Wuhan	NNP
cord-311749-yp313biv	29	32	met	meet	VBD
cord-311749-yp313biv	29	33	criteria	criterion	NNS
cord-311749-yp313biv	29	34	for	for	IN
cord-311749-yp313biv	29	35	ARDS	ARDS	NNP
cord-311749-yp313biv	29	36	(	(	-LRB-
cord-311749-yp313biv	29	37	8)	8)	NNP
cord-311749-yp313biv	29	38	.	.	.
cord-311749-yp313biv	30	1	This	this	DT
cord-311749-yp313biv	30	2	model	model	NN
cord-311749-yp313biv	30	3	of	of	IN
cord-311749-yp313biv	30	4	a	a	DT
cord-311749-yp313biv	30	5	hyperinflammatory	hyperinflammatory	JJ
cord-311749-yp313biv	30	6	syndrome	syndrome	NN
cord-311749-yp313biv	30	7	occurring	occur	VBG
cord-311749-yp313biv	30	8	a	a	DT
cord-311749-yp313biv	30	9	week	week	NN
cord-311749-yp313biv	30	10	or	or	CC
cord-311749-yp313biv	30	11	more	more	JJR
cord-311749-yp313biv	30	12	after	after	IN
cord-311749-yp313biv	30	13	initial	initial	JJ
cord-311749-yp313biv	30	14	infection	infection	NN
cord-311749-yp313biv	30	15	,	,	,
cord-311749-yp313biv	30	16	leading	lead	VBG
cord-311749-yp313biv	30	17	to	to	IN
cord-311749-yp313biv	30	18	ARDS	ARDS	NNP
cord-311749-yp313biv	30	19	and	and	CC
cord-311749-yp313biv	30	20	a	a	DT
cord-311749-yp313biv	30	21	need	need	NN
cord-311749-yp313biv	30	22	for	for	IN
cord-311749-yp313biv	30	23	mechanical	mechanical	JJ
cord-311749-yp313biv	30	24	ventilation	ventilation	NN
cord-311749-yp313biv	30	25	,	,	,
cord-311749-yp313biv	30	26	is	be	VBZ
cord-311749-yp313biv	30	27	further	further	RB
cord-311749-yp313biv	30	28	supported	support	VBN
cord-311749-yp313biv	30	29	by	by	IN
cord-311749-yp313biv	30	30	the	the	DT
cord-311749-yp313biv	30	31	benefits	benefit	NNS
cord-311749-yp313biv	30	32	of	of	IN
cord-311749-yp313biv	30	33	dexamethasone	dexamethasone	NN
cord-311749-yp313biv	30	34	in	in	IN
cord-311749-yp313biv	30	35	the	the	DT
cord-311749-yp313biv	30	36	recently	recently	RB
cord-311749-yp313biv	30	37	published	publish	VBN
cord-311749-yp313biv	30	38	RECOVERY	recovery	NN
cord-311749-yp313biv	30	39	(	(	-LRB-
cord-311749-yp313biv	30	40	Randomized	Randomized	NNP
cord-311749-yp313biv	30	41	Evaluation	Evaluation	NNP
cord-311749-yp313biv	30	42	of	of	IN
cord-311749-yp313biv	30	43	COVID-19	COVID-19	NNP
cord-311749-yp313biv	30	44	Therapy	Therapy	NNP
cord-311749-yp313biv	30	45	)	)	-RRB-
cord-311749-yp313biv	30	46	trial	trial	NN
cord-311749-yp313biv	30	47	(	(	-LRB-
cord-311749-yp313biv	30	48	9	9	CD
cord-311749-yp313biv	30	49	)	)	-RRB-
cord-311749-yp313biv	30	50	.	.	.
cord-311749-yp313biv	31	1	In	in	IN
cord-311749-yp313biv	31	2	this	this	DT
cord-311749-yp313biv	31	3	large	large	JJ
cord-311749-yp313biv	31	4	,	,	,
cord-311749-yp313biv	31	5	open	open	JJ
cord-311749-yp313biv	31	6	-	-	HYPH
cord-311749-yp313biv	31	7	label	label	NN
cord-311749-yp313biv	31	8	,	,	,
cord-311749-yp313biv	31	9	United	United	NNP
cord-311749-yp313biv	31	10	Kingdom	Kingdom	NNP
cord-311749-yp313biv	31	11	-	-	HYPH
cord-311749-yp313biv	31	12	based	base	VBN
cord-311749-yp313biv	31	13	trial	trial	NN
cord-311749-yp313biv	31	14	,	,	,
cord-311749-yp313biv	31	15	dexamethasone	dexamethasone	NN
cord-311749-yp313biv	31	16	significantly	significantly	RB
cord-311749-yp313biv	31	17	reduced	reduce	VBD
cord-311749-yp313biv	31	18	COVID-19	COVID-19	NNP
cord-311749-yp313biv	31	19	mortality	mortality	NN
cord-311749-yp313biv	31	20	,	,	,
cord-311749-yp313biv	31	21	with	with	IN
cord-311749-yp313biv	31	22	the	the	DT
cord-311749-yp313biv	31	23	largest	large	JJS
cord-311749-yp313biv	31	24	effect	effect	NN
cord-311749-yp313biv	31	25	in	in	IN
cord-311749-yp313biv	31	26	those	those	DT
cord-311749-yp313biv	31	27	requiring	require	VBG
cord-311749-yp313biv	31	28	mechanical	mechanical	JJ
cord-311749-yp313biv	31	29	ventilation	ventilation	NN
cord-311749-yp313biv	31	30	(	(	-LRB-
cord-311749-yp313biv	31	31	9	9	CD
cord-311749-yp313biv	31	32	)	)	-RRB-
cord-311749-yp313biv	31	33	.	.	.
cord-311749-yp313biv	32	1	Most	most	RBS
cord-311749-yp313biv	32	2	notably	notably	RB
cord-311749-yp313biv	32	3	,	,	,
cord-311749-yp313biv	32	4	in	in	IN
cord-311749-yp313biv	32	5	the	the	DT
cord-311749-yp313biv	32	6	supplementary	supplementary	JJ
cord-311749-yp313biv	32	7	material	material	NN
cord-311749-yp313biv	32	8	,	,	,
cord-311749-yp313biv	32	9	patients	patient	NNS
cord-311749-yp313biv	32	10	starting	start	VBG
cord-311749-yp313biv	32	11	dexamethasone	dexamethasone	VBN
cord-311749-yp313biv	33	1	.7	.7	NFP
cord-311749-yp313biv	33	2	days	day	NNS
cord-311749-yp313biv	33	3	after	after	IN
cord-311749-yp313biv	33	4	symptom	symptom	NN
cord-311749-yp313biv	33	5	onset	onset	NN
cord-311749-yp313biv	33	6	demonstrated	demonstrate	VBD
cord-311749-yp313biv	33	7	the	the	DT
cord-311749-yp313biv	33	8	most	most	RBS
cord-311749-yp313biv	33	9	significant	significant	JJ
cord-311749-yp313biv	33	10	benefit	benefit	NN
cord-311749-yp313biv	33	11	,	,	,
cord-311749-yp313biv	33	12	whereas	whereas	IN
cord-311749-yp313biv	33	13	those	those	DT
cord-311749-yp313biv	33	14	treated	treat	VBN
cord-311749-yp313biv	33	15	in	in	IN
cord-311749-yp313biv	33	16	the	the	DT
cord-311749-yp313biv	33	17	first	first	JJ
cord-311749-yp313biv	33	18	7	7	CD
cord-311749-yp313biv	33	19	days	day	NNS
cord-311749-yp313biv	33	20	from	from	IN
cord-311749-yp313biv	33	21	symptom	symptom	NN
cord-311749-yp313biv	33	22	onset	onset	NN
cord-311749-yp313biv	33	23	did	do	VBD
cord-311749-yp313biv	33	24	not	not	RB
cord-311749-yp313biv	33	25	,	,	,
cord-311749-yp313biv	33	26	validating	validate	VBG
cord-311749-yp313biv	33	27	the	the	DT
cord-311749-yp313biv	33	28	proposed	propose	VBN
cord-311749-yp313biv	33	29	model	model	NN
cord-311749-yp313biv	33	30	of	of	IN
cord-311749-yp313biv	33	31	a	a	DT
cord-311749-yp313biv	33	32	late	late	JJ
cord-311749-yp313biv	33	33	hyperinflammatory	hyperinflammatory	JJ
cord-311749-yp313biv	33	34	response	response	NN
cord-311749-yp313biv	33	35	that	that	WDT
cord-311749-yp313biv	33	36	can	can	MD
cord-311749-yp313biv	33	37	be	be	VB
cord-311749-yp313biv	33	38	therapeutically	therapeutically	RB
cord-311749-yp313biv	33	39	targeted	target	VBN
cord-311749-yp313biv	33	40	.	.	.
cord-311749-yp313biv	34	1	In	in	IN
cord-311749-yp313biv	34	2	parallel	parallel	NN
cord-311749-yp313biv	34	3	to	to	IN
cord-311749-yp313biv	34	4	evidence	evidence	NN
cord-311749-yp313biv	34	5	of	of	IN
cord-311749-yp313biv	34	6	excess	excess	JJ
cord-311749-yp313biv	34	7	inflammation	inflammation	NN
cord-311749-yp313biv	34	8	,	,	,
cord-311749-yp313biv	34	9	reports	report	NNS
cord-311749-yp313biv	34	10	of	of	IN
cord-311749-yp313biv	34	11	profound	profound	JJ
cord-311749-yp313biv	34	12	viral	viral	JJ
cord-311749-yp313biv	34	13	-	-	HYPH
cord-311749-yp313biv	34	14	induced	induce	VBN
cord-311749-yp313biv	34	15	immunosuppression	immunosuppression	NN
cord-311749-yp313biv	34	16	have	have	VBP
cord-311749-yp313biv	34	17	emerged	emerge	VBN
cord-311749-yp313biv	34	18	.	.	.
cord-311749-yp313biv	35	1	Specifically	specifically	RB
cord-311749-yp313biv	35	2	,	,	,
cord-311749-yp313biv	35	3	deficient	deficient	JJ
cord-311749-yp313biv	35	4	production	production	NN
cord-311749-yp313biv	35	5	of	of	IN
cord-311749-yp313biv	35	6	IFN	IFN	NNP
cord-311749-yp313biv	35	7	-	-	:
cord-311749-yp313biv	35	8	a	a	NN
cord-311749-yp313biv	35	9	and	and	CC
cord-311749-yp313biv	35	10	-b	-b	SYM
cord-311749-yp313biv	35	11	in	in	IN
cord-311749-yp313biv	35	12	blood	blood	NN
cord-311749-yp313biv	35	13	is	be	VBZ
cord-311749-yp313biv	35	14	reported	report	VBN
cord-311749-yp313biv	35	15	in	in	IN
cord-311749-yp313biv	35	16	patients	patient	NNS
cord-311749-yp313biv	35	17	with	with	IN
cord-311749-yp313biv	35	18	severe	severe	JJ
cord-311749-yp313biv	35	19	disease	disease	NN
cord-311749-yp313biv	35	20	,	,	,
cord-311749-yp313biv	35	21	whereas	whereas	IN
cord-311749-yp313biv	35	22	a	a	DT
cord-311749-yp313biv	35	23	separate	separate	JJ
cord-311749-yp313biv	35	24	study	study	NN
cord-311749-yp313biv	35	25	describes	describe	VBZ
cord-311749-yp313biv	35	26	deficient	deficient	JJ
cord-311749-yp313biv	35	27	IFN	IFN	NNP
cord-311749-yp313biv	35	28	-	-	HYPH
cord-311749-yp313biv	35	29	g	g	NNP
cord-311749-yp313biv	35	30	and	and	CC
cord-311749-yp313biv	35	31	TNF	TNF	NNP
cord-311749-yp313biv	35	32	-	-	:
cord-311749-yp313biv	35	33	a	a	DT
cord-311749-yp313biv	35	34	production	production	NN
cord-311749-yp313biv	35	35	(	(	-LRB-
cord-311749-yp313biv	35	36	10	10	CD
cord-311749-yp313biv	35	37	,	,	,
cord-311749-yp313biv	35	38	11	11	CD
cord-311749-yp313biv	35	39	)	)	-RRB-
cord-311749-yp313biv	35	40	.	.	.
cord-311749-yp313biv	36	1	Taken	take	VBN
cord-311749-yp313biv	36	2	together	together	RB
cord-311749-yp313biv	36	3	,	,	,
cord-311749-yp313biv	36	4	severe	severe	JJ
cord-311749-yp313biv	36	5	COVID-19	COVID-19	NNP
cord-311749-yp313biv	36	6	appears	appear	VBZ
cord-311749-yp313biv	36	7	to	to	TO
cord-311749-yp313biv	36	8	involve	involve	VB
cord-311749-yp313biv	36	9	a	a	DT
cord-311749-yp313biv	36	10	delicate	delicate	JJ
cord-311749-yp313biv	36	11	and	and	CC
cord-311749-yp313biv	36	12	dynamic	dynamic	JJ
cord-311749-yp313biv	36	13	balance	balance	NN
cord-311749-yp313biv	36	14	between	between	IN
cord-311749-yp313biv	36	15	excess	excess	JJ
cord-311749-yp313biv	36	16	inflammation	inflammation	NN
cord-311749-yp313biv	36	17	and	and	CC
cord-311749-yp313biv	36	18	deficient	deficient	JJ
cord-311749-yp313biv	36	19	antiinflammatory	antiinflammatory	JJ
cord-311749-yp313biv	36	20	and	and	CC
cord-311749-yp313biv	36	21	antiviral	antiviral	JJ
cord-311749-yp313biv	36	22	defenses	defense	NNS
cord-311749-yp313biv	36	23	.	.	.
cord-311749-yp313biv	37	1	The	the	DT
cord-311749-yp313biv	37	2	clinical	clinical	JJ
cord-311749-yp313biv	37	3	presentation	presentation	NN
cord-311749-yp313biv	37	4	and	and	CC
cord-311749-yp313biv	37	5	immunological	immunological	JJ
cord-311749-yp313biv	37	6	profile	profile	NN
cord-311749-yp313biv	37	7	of	of	IN
cord-311749-yp313biv	37	8	COVID-19	COVID-19	NNP
cord-311749-yp313biv	37	9	is	be	VBZ
cord-311749-yp313biv	37	10	therefore	therefore	RB
cord-311749-yp313biv	37	11	unique	unique	JJ
cord-311749-yp313biv	37	12	,	,	,
cord-311749-yp313biv	37	13	and	and	CC
cord-311749-yp313biv	37	14	intensive	intensive	JJ
cord-311749-yp313biv	37	15	research	research	NN
cord-311749-yp313biv	37	16	aimed	aim	VBN
cord-311749-yp313biv	37	17	at	at	IN
cord-311749-yp313biv	37	18	characterizing	characterize	VBG
cord-311749-yp313biv	37	19	this	this	DT
cord-311749-yp313biv	37	20	is	be	VBZ
cord-311749-yp313biv	37	21	ongoing	ongoing	JJ
cord-311749-yp313biv	37	22	.	.	.
cord-311749-yp313biv	38	1	Most	Most	JJS
cord-311749-yp313biv	38	2	mortality	mortality	NN
cord-311749-yp313biv	38	3	is	be	VBZ
cord-311749-yp313biv	38	4	likely	likely	JJ
cord-311749-yp313biv	38	5	to	to	TO
cord-311749-yp313biv	38	6	be	be	VB
cord-311749-yp313biv	38	7	driven	drive	VBN
cord-311749-yp313biv	38	8	by	by	IN
cord-311749-yp313biv	38	9	host	host	NN
cord-311749-yp313biv	38	10	responses	response	NNS
cord-311749-yp313biv	38	11	rather	rather	RB
cord-311749-yp313biv	38	12	than	than	IN
cord-311749-yp313biv	38	13	the	the	DT
cord-311749-yp313biv	38	14	virus	virus	NN
cord-311749-yp313biv	38	15	,	,	,
cord-311749-yp313biv	38	16	and	and	CC
cord-311749-yp313biv	38	17	there	there	EX
cord-311749-yp313biv	38	18	is	be	VBZ
cord-311749-yp313biv	38	19	clear	clear	JJ
cord-311749-yp313biv	38	20	evidence	evidence	NN
cord-311749-yp313biv	38	21	of	of	IN
cord-311749-yp313biv	38	22	end	end	NN
cord-311749-yp313biv	38	23	-	-	HYPH
cord-311749-yp313biv	38	24	organ	organ	NN
cord-311749-yp313biv	38	25	damage	damage	NN
cord-311749-yp313biv	38	26	without	without	IN
cord-311749-yp313biv	38	27	evidence	evidence	NN
cord-311749-yp313biv	38	28	of	of	IN
cord-311749-yp313biv	38	29	viral	viral	JJ
cord-311749-yp313biv	38	30	invasion	invasion	NN
cord-311749-yp313biv	38	31	.	.	.
cord-311749-yp313biv	39	1	It	-PRON-	PRP
cord-311749-yp313biv	39	2	is	be	VBZ
cord-311749-yp313biv	39	3	a	a	DT
cord-311749-yp313biv	39	4	remarkable	remarkable	JJ
cord-311749-yp313biv	39	5	triumph	triumph	NN
cord-311749-yp313biv	39	6	for	for	IN
cord-311749-yp313biv	39	7	clinical	clinical	JJ
cord-311749-yp313biv	39	8	and	and	CC
cord-311749-yp313biv	39	9	translational	translational	JJ
cord-311749-yp313biv	39	10	research	research	NN
cord-311749-yp313biv	39	11	that	that	WDT
cord-311749-yp313biv	39	12	we	-PRON-	PRP
cord-311749-yp313biv	39	13	know	know	VBP
cord-311749-yp313biv	39	14	so	so	RB
cord-311749-yp313biv	39	15	much	much	JJ
cord-311749-yp313biv	39	16	about	about	IN
cord-311749-yp313biv	39	17	the	the	DT
cord-311749-yp313biv	39	18	inflammatory	inflammatory	JJ
cord-311749-yp313biv	39	19	response	response	NN
cord-311749-yp313biv	39	20	to	to	IN
cord-311749-yp313biv	39	21	SARS	SARS	NNP
cord-311749-yp313biv	39	22	-	-	HYPH
cord-311749-yp313biv	39	23	CoV-2	CoV-2	NNP
cord-311749-yp313biv	39	24	only	only	RB
cord-311749-yp313biv	39	25	6	6	CD
cord-311749-yp313biv	39	26	months	month	NNS
cord-311749-yp313biv	39	27	after	after	IN
cord-311749-yp313biv	39	28	the	the	DT
cord-311749-yp313biv	39	29	publication	publication	NN
cord-311749-yp313biv	39	30	of	of	IN
cord-311749-yp313biv	39	31	its	-PRON-	PRP$
cord-311749-yp313biv	39	32	gene	gene	NN
cord-311749-yp313biv	39	33	sequence	sequence	NN
cord-311749-yp313biv	39	34	.	.	.
cord-311749-yp313biv	40	1	Nevertheless	nevertheless	RB
cord-311749-yp313biv	40	2	,	,	,
cord-311749-yp313biv	40	3	key	key	JJ
cord-311749-yp313biv	40	4	questions	question	NNS
cord-311749-yp313biv	40	5	remain	remain	VBP
cord-311749-yp313biv	40	6	about	about	IN
cord-311749-yp313biv	40	7	its	-PRON-	PRP$
cord-311749-yp313biv	40	8	pathophysiology	pathophysiology	NN
cord-311749-yp313biv	40	9	:	:	:
cord-311749-yp313biv	40	10	which	which	WDT
cord-311749-yp313biv	40	11	components	component	NNS
cord-311749-yp313biv	40	12	of	of	IN
cord-311749-yp313biv	40	13	the	the	DT
cord-311749-yp313biv	40	14	inflammatory	inflammatory	JJ
cord-311749-yp313biv	40	15	response	response	NN
cord-311749-yp313biv	40	16	are	be	VBP
cord-311749-yp313biv	40	17	key	key	JJ
cord-311749-yp313biv	40	18	"	"	``
cord-311749-yp313biv	40	19	makers	maker	NNS
cord-311749-yp313biv	40	20	"	"	''
cord-311749-yp313biv	40	21	rather	rather	RB
cord-311749-yp313biv	40	22	than	than	IN
cord-311749-yp313biv	40	23	"	"	``
cord-311749-yp313biv	40	24	markers	marker	NNS
cord-311749-yp313biv	40	25	,	,	,
cord-311749-yp313biv	40	26	"	"	''
cord-311749-yp313biv	40	27	and	and	CC
cord-311749-yp313biv	40	28	what	what	WP
cord-311749-yp313biv	40	29	should	should	MD
cord-311749-yp313biv	40	30	be	be	VB
cord-311749-yp313biv	40	31	therapeutically	therapeutically	RB
cord-311749-yp313biv	40	32	targeted	target	VBN
cord-311749-yp313biv	40	33	(	(	-LRB-
cord-311749-yp313biv	40	34	12	12	CD
cord-311749-yp313biv	40	35	)	)	-RRB-
cord-311749-yp313biv	40	36	?	?	.
cord-311749-yp313biv	41	1	What	what	WDT
cord-311749-yp313biv	41	2	inflammatory	inflammatory	JJ
cord-311749-yp313biv	41	3	characteristics	characteristic	NNS
cord-311749-yp313biv	41	4	distinguish	distinguish	VBP
cord-311749-yp313biv	41	5	between	between	IN
cord-311749-yp313biv	41	6	the	the	DT
cord-311749-yp313biv	41	7	different	different	JJ
cord-311749-yp313biv	41	8	stages	stage	NNS
cord-311749-yp313biv	41	9	of	of	IN
cord-311749-yp313biv	41	10	disease	disease	NN
cord-311749-yp313biv	41	11	,	,	,
cord-311749-yp313biv	41	12	and	and	CC
cord-311749-yp313biv	41	13	is	be	VBZ
cord-311749-yp313biv	41	14	this	this	DT
cord-311749-yp313biv	41	15	useful	useful	JJ
cord-311749-yp313biv	41	16	for	for	IN
cord-311749-yp313biv	41	17	risk	risk	NN
cord-311749-yp313biv	41	18	stratification	stratification	NN
cord-311749-yp313biv	41	19	?	?	.
cord-311749-yp313biv	42	1	Finally	finally	RB
cord-311749-yp313biv	42	2	,	,	,
cord-311749-yp313biv	42	3	some	some	DT
cord-311749-yp313biv	42	4	aspects	aspect	NNS
cord-311749-yp313biv	42	5	of	of	IN
cord-311749-yp313biv	42	6	the	the	DT
cord-311749-yp313biv	42	7	immune	immune	JJ
cord-311749-yp313biv	42	8	response	response	NN
cord-311749-yp313biv	42	9	remain	remain	VBP
cord-311749-yp313biv	42	10	less	less	RBR
cord-311749-yp313biv	42	11	well	well	RB
cord-311749-yp313biv	42	12	characterized	characterize	VBN
cord-311749-yp313biv	42	13	,	,	,
cord-311749-yp313biv	42	14	and	and	CC
cord-311749-yp313biv	42	15	in	in	IN
cord-311749-yp313biv	42	16	particular	particular	JJ
cord-311749-yp313biv	42	17	,	,	,
cord-311749-yp313biv	42	18	the	the	DT
cord-311749-yp313biv	42	19	contribution	contribution	NN
cord-311749-yp313biv	42	20	of	of	IN
cord-311749-yp313biv	42	21	neutrophils	neutrophil	NNS
cord-311749-yp313biv	42	22	to	to	IN
cord-311749-yp313biv	42	23	COVID-19	covid-19	VB
cord-311749-yp313biv	42	24	remains	remain	VBZ
cord-311749-yp313biv	42	25	unclear	unclear	JJ
cord-311749-yp313biv	42	26	(	(	-LRB-
cord-311749-yp313biv	42	27	13	13	CD
cord-311749-yp313biv	42	28	)	)	-RRB-
cord-311749-yp313biv	42	29	.	.	.
cord-311749-yp313biv	43	1	In	in	IN
cord-311749-yp313biv	43	2	this	this	DT
cord-311749-yp313biv	43	3	issue	issue	NN
cord-311749-yp313biv	43	4	of	of	IN
cord-311749-yp313biv	43	5	the	the	DT
cord-311749-yp313biv	43	6	Journal	Journal	NNP
cord-311749-yp313biv	43	7	,	,	,
cord-311749-yp313biv	43	8	McElvaney	McElvaney	NNP
cord-311749-yp313biv	43	9	and	and	CC
cord-311749-yp313biv	43	10	colleagues	colleague	NNS
cord-311749-yp313biv	43	11	(	(	-LRB-
cord-311749-yp313biv	43	12	pp	pp	NNP
cord-311749-yp313biv	43	13	.	.	.
cord-311749-yp313biv	43	14	812	812	CD
cord-311749-yp313biv	43	15	-	-	SYM
cord-311749-yp313biv	43	16	821	821	CD
cord-311749-yp313biv	43	17	)	)	-RRB-
cord-311749-yp313biv	43	18	,	,	,
cord-311749-yp313biv	43	19	in	in	IN
cord-311749-yp313biv	43	20	a	a	DT
cord-311749-yp313biv	43	21	single	single	JJ
cord-311749-yp313biv	43	22	-	-	HYPH
cord-311749-yp313biv	43	23	center	center	NN
cord-311749-yp313biv	43	24	study	study	NN
cord-311749-yp313biv	43	25	from	from	IN
cord-311749-yp313biv	43	26	Dublin	Dublin	NNP
cord-311749-yp313biv	43	27	,	,	,
cord-311749-yp313biv	43	28	Ireland	Ireland	NNP
cord-311749-yp313biv	43	29	,	,	,
cord-311749-yp313biv	43	30	aim	aim	VBP
cord-311749-yp313biv	43	31	to	to	TO
cord-311749-yp313biv	43	32	provide	provide	VB
cord-311749-yp313biv	43	33	fresh	fresh	JJ
cord-311749-yp313biv	43	34	insight	insight	NN
cord-311749-yp313biv	43	35	into	into	IN
cord-311749-yp313biv	43	36	the	the	DT
cord-311749-yp313biv	43	37	inflammatory	inflammatory	JJ
cord-311749-yp313biv	43	38	response	response	NN
cord-311749-yp313biv	43	39	to	to	IN
cord-311749-yp313biv	43	40	COVID-19	COVID-19	NNP
cord-311749-yp313biv	43	41	(	(	-LRB-
cord-311749-yp313biv	43	42	14	14	CD
cord-311749-yp313biv	43	43	)	)	-RRB-
cord-311749-yp313biv	43	44	.	.	.
cord-311749-yp313biv	44	1	The	the	DT
cord-311749-yp313biv	44	2	study	study	NN
cord-311749-yp313biv	44	3	compared	compare	VBD
cord-311749-yp313biv	44	4	20	20	CD
cord-311749-yp313biv	44	5	patients	patient	NNS
cord-311749-yp313biv	44	6	requiring	require	VBG
cord-311749-yp313biv	44	7	intensive	intensive	JJ
cord-311749-yp313biv	44	8	care	care	NN
cord-311749-yp313biv	44	9	admission	admission	NN
cord-311749-yp313biv	44	10	for	for	IN
cord-311749-yp313biv	44	11	severe	severe	JJ
cord-311749-yp313biv	44	12	COVID-19	covid-19	JJ
cord-311749-yp313biv	44	13	infection	infection	NN
cord-311749-yp313biv	44	14	,	,	,
cord-311749-yp313biv	44	15	20	20	CD
cord-311749-yp313biv	44	16	patients	patient	NNS
cord-311749-yp313biv	44	17	who	who	WP
cord-311749-yp313biv	44	18	were	be	VBD
cord-311749-yp313biv	44	19	hospitalized	hospitalize	VBN
cord-311749-yp313biv	44	20	with	with	IN
cord-311749-yp313biv	44	21	stable	stable	JJ
cord-311749-yp313biv	44	22	COVID-19	covid-19	JJ
cord-311749-yp313biv	44	23	infection	infection	NN
cord-311749-yp313biv	44	24	(	(	-LRB-
cord-311749-yp313biv	44	25	who	who	WP
cord-311749-yp313biv	44	26	did	do	VBD
cord-311749-yp313biv	44	27	not	not	RB
cord-311749-yp313biv	44	28	require	require	VB
cord-311749-yp313biv	44	29	ICU	ICU	NNP
cord-311749-yp313biv	44	30	admission	admission	NN
cord-311749-yp313biv	44	31	)	)	-RRB-
cord-311749-yp313biv	44	32	,	,	,
cord-311749-yp313biv	44	33	and	and	CC
cord-311749-yp313biv	44	34	15	15	CD
cord-311749-yp313biv	44	35	healthy	healthy	JJ
cord-311749-yp313biv	44	36	controls	control	NNS
cord-311749-yp313biv	44	37	.	.	.
cord-311749-yp313biv	45	1	The	the	DT
cord-311749-yp313biv	45	2	study	study	NN
cord-311749-yp313biv	45	3	confirmed	confirm	VBD
cord-311749-yp313biv	45	4	prior	prior	JJ
cord-311749-yp313biv	45	5	observations	observation	NNS
cord-311749-yp313biv	45	6	with	with	IN
cord-311749-yp313biv	45	7	elevated	elevated	JJ
cord-311749-yp313biv	45	8	IL-6	IL-6	NNP
cord-311749-yp313biv	45	9	,	,	,
cord-311749-yp313biv	45	10	IL-1b	IL-1b	NNS
cord-311749-yp313biv	45	11	,	,	,
cord-311749-yp313biv	45	12	soluble	soluble	JJ
cord-311749-yp313biv	45	13	TNF	TNF	NNP
cord-311749-yp313biv	45	14	receptor-1	receptor-1	NNP
cord-311749-yp313biv	45	15	,	,	,
cord-311749-yp313biv	45	16	and	and	CC
cord-311749-yp313biv	46	1	IL-8	IL-8	NNP
cord-311749-yp313biv	46	2	in	in	IN
cord-311749-yp313biv	46	3	the	the	DT
cord-311749-yp313biv	46	4	plasma	plasma	NN
cord-311749-yp313biv	46	5	of	of	IN
cord-311749-yp313biv	46	6	severe	severe	JJ
cord-311749-yp313biv	46	7	cases	case	NNS
cord-311749-yp313biv	46	8	requiring	require	VBG
cord-311749-yp313biv	46	9	ICU	ICU	NNP
cord-311749-yp313biv	46	10	admission	admission	NN
cord-311749-yp313biv	46	11	,	,	,
cord-311749-yp313biv	46	12	with	with	IN
cord-311749-yp313biv	46	13	elevated	elevated	JJ
cord-311749-yp313biv	46	14	ratios	ratio	NNS
cord-311749-yp313biv	46	15	of	of	IN
cord-311749-yp313biv	46	16	IL-6	IL-6	NNP
cord-311749-yp313biv	46	17	and	and	CC
cord-311749-yp313biv	46	18	IL-1b	IL-1b	VBZ
cord-311749-yp313biv	46	19	to	to	IN
cord-311749-yp313biv	46	20	the	the	DT
cord-311749-yp313biv	46	21	antiinflammatory	antiinflammatory	JJ
cord-311749-yp313biv	46	22	cytokine	cytokine	NN
cord-311749-yp313biv	46	23	IL-10	IL-10	NNP
cord-311749-yp313biv	46	24	.	.	.
cord-311749-yp313biv	47	1	Metabolic	metabolic	JJ
cord-311749-yp313biv	47	2	reprogramming	reprogramming	NN
cord-311749-yp313biv	47	3	of	of	IN
cord-311749-yp313biv	47	4	immune	immune	JJ
cord-311749-yp313biv	47	5	cells	cell	NNS
cord-311749-yp313biv	47	6	refers	refer	VBZ
cord-311749-yp313biv	47	7	to	to	IN
cord-311749-yp313biv	47	8	complex	complex	JJ
cord-311749-yp313biv	47	9	alterations	alteration	NNS
cord-311749-yp313biv	47	10	in	in	IN
cord-311749-yp313biv	47	11	cell	cell	NN
cord-311749-yp313biv	47	12	metabolism	metabolism	NN
cord-311749-yp313biv	47	13	,	,	,
cord-311749-yp313biv	47	14	typically	typically	RB
cord-311749-yp313biv	47	15	occurring	occur	VBG
cord-311749-yp313biv	47	16	upon	upon	IN
cord-311749-yp313biv	47	17	activation	activation	NN
cord-311749-yp313biv	47	18	by	by	IN
cord-311749-yp313biv	47	19	external	external	JJ
cord-311749-yp313biv	47	20	stimuli	stimulus	NNS
cord-311749-yp313biv	47	21	such	such	JJ
cord-311749-yp313biv	47	22	as	as	IN
cord-311749-yp313biv	47	23	cytokines	cytokine	NNS
cord-311749-yp313biv	47	24	,	,	,
cord-311749-yp313biv	47	25	leading	lead	VBG
cord-311749-yp313biv	47	26	to	to	IN
cord-311749-yp313biv	47	27	profound	profound	JJ
cord-311749-yp313biv	47	28	change	change	NN
cord-311749-yp313biv	47	29	to	to	IN
cord-311749-yp313biv	47	30	their	-PRON-	PRP$
cord-311749-yp313biv	47	31	function	function	NN
cord-311749-yp313biv	47	32	.	.	.
cord-311749-yp313biv	48	1	Neutrophil	Neutrophil	NNP
cord-311749-yp313biv	48	2	metabolic	metabolic	JJ
cord-311749-yp313biv	48	3	reprogramming	reprogramming	NN
cord-311749-yp313biv	48	4	,	,	,
cord-311749-yp313biv	48	5	or	or	CC
cord-311749-yp313biv	48	6	what	what	WP
cord-311749-yp313biv	48	7	the	the	DT
cord-311749-yp313biv	48	8	authors	author	NNS
cord-311749-yp313biv	48	9	refer	refer	VBP
cord-311749-yp313biv	48	10	to	to	IN
cord-311749-yp313biv	48	11	as	as	IN
cord-311749-yp313biv	48	12	"	"	``
cord-311749-yp313biv	48	13	rewiring	rewiring	NN
cord-311749-yp313biv	48	14	,	,	,
cord-311749-yp313biv	48	15	"	"	''
cord-311749-yp313biv	48	16	is	be	VBZ
cord-311749-yp313biv	48	17	reported	report	VBN
cord-311749-yp313biv	48	18	in	in	IN
cord-311749-yp313biv	48	19	cystic	cystic	JJ
cord-311749-yp313biv	48	20	fibrosis	fibrosis	NN
cord-311749-yp313biv	48	21	and	and	CC
cord-311749-yp313biv	48	22	other	other	JJ
cord-311749-yp313biv	48	23	conditions	condition	NNS
cord-311749-yp313biv	48	24	in	in	IN
cord-311749-yp313biv	48	25	response	response	NN
cord-311749-yp313biv	48	26	to	to	IN
cord-311749-yp313biv	48	27	inflammatory	inflammatory	JJ
cord-311749-yp313biv	48	28	cytokines	cytokine	NNS
cord-311749-yp313biv	48	29	and	and	CC
cord-311749-yp313biv	48	30	low	low	JJ
cord-311749-yp313biv	48	31	-	-	HYPH
cord-311749-yp313biv	48	32	level	level	NN
cord-311749-yp313biv	48	33	endotoxemia	endotoxemia	NN
cord-311749-yp313biv	48	34	(	(	-LRB-
cord-311749-yp313biv	48	35	15	15	CD
cord-311749-yp313biv	48	36	)	)	-RRB-
cord-311749-yp313biv	48	37	.	.	.
cord-311749-yp313biv	49	1	These	these	DT
cord-311749-yp313biv	49	2	observations	observation	NNS
cord-311749-yp313biv	49	3	are	be	VBP
cord-311749-yp313biv	49	4	extended	extend	VBN
cord-311749-yp313biv	49	5	here	here	RB
cord-311749-yp313biv	49	6	with	with	IN
cord-311749-yp313biv	49	7	increased	increase	VBN
cord-311749-yp313biv	49	8	levels	level	NNS
cord-311749-yp313biv	49	9	of	of	IN
cord-311749-yp313biv	49	10	HIF1-a	HIF1-a	NNP
cord-311749-yp313biv	49	11	,	,	,
cord-311749-yp313biv	49	12	PKM2	PKM2	NNP
cord-311749-yp313biv	49	13	,	,	,
cord-311749-yp313biv	49	14	and	and	CC
cord-311749-yp313biv	49	15	cytosolic	cytosolic	JJ
cord-311749-yp313biv	49	16	lactate	lactate	NN
cord-311749-yp313biv	49	17	in	in	IN
cord-311749-yp313biv	49	18	neutrophils	neutrophil	NNS
cord-311749-yp313biv	49	19	from	from	IN
cord-311749-yp313biv	49	20	patients	patient	NNS
cord-311749-yp313biv	49	21	with	with	IN
cord-311749-yp313biv	49	22	COVID-19	COVID-19	NNP
cord-311749-yp313biv	49	23	.	.	.
cord-311749-yp313biv	50	1	Importantly	importantly	RB
cord-311749-yp313biv	50	2	,	,	,
cord-311749-yp313biv	50	3	however	however	RB
cord-311749-yp313biv	50	4	,	,	,
cord-311749-yp313biv	50	5	precise	precise	JJ
cord-311749-yp313biv	50	6	mechanisms	mechanism	NNS
cord-311749-yp313biv	50	7	for	for	IN
cord-311749-yp313biv	50	8	these	these	DT
cord-311749-yp313biv	50	9	effects	effect	NNS
cord-311749-yp313biv	50	10	remain	remain	VBP
cord-311749-yp313biv	50	11	undefined	undefined	JJ
cord-311749-yp313biv	50	12	and	and	CC
cord-311749-yp313biv	50	13	are	be	VBP
cord-311749-yp313biv	50	14	likely	likely	JJ
cord-311749-yp313biv	50	15	to	to	TO
cord-311749-yp313biv	50	16	be	be	VB
cord-311749-yp313biv	50	17	multifactorial	multifactorial	JJ
cord-311749-yp313biv	50	18	given	give	VBN
cord-311749-yp313biv	50	19	the	the	DT
cord-311749-yp313biv	50	20	combined	combine	VBN
cord-311749-yp313biv	50	21	effects	effect	NNS
cord-311749-yp313biv	50	22	of	of	IN
cord-311749-yp313biv	50	23	proinflammatory	proinflammatory	JJ
cord-311749-yp313biv	50	24	mediators	mediator	NNS
cord-311749-yp313biv	50	25	and	and	CC
cord-311749-yp313biv	50	26	hypoxemia	hypoxemia	NN
cord-311749-yp313biv	50	27	in	in	IN
cord-311749-yp313biv	50	28	severe	severe	JJ
cord-311749-yp313biv	50	29	COVID-19	covid-19	NN
cord-311749-yp313biv	50	30	.	.	.
cord-311749-yp313biv	51	1	Finally	finally	RB
cord-311749-yp313biv	51	2	,	,	,
cord-311749-yp313biv	51	3	the	the	DT
cord-311749-yp313biv	51	4	authors	author	NNS
cord-311749-yp313biv	51	5	assessed	assess	VBD
cord-311749-yp313biv	51	6	plasma	plasma	NN
cord-311749-yp313biv	51	7	alpha-1	alpha-1	NN
cord-311749-yp313biv	51	8	antitrypsin	antitrypsin	NN
cord-311749-yp313biv	51	9	(	(	-LRB-
cord-311749-yp313biv	51	10	AAT	AAT	NNP
cord-311749-yp313biv	51	11	)	)	-RRB-
cord-311749-yp313biv	51	12	,	,	,
cord-311749-yp313biv	51	13	which	which	WDT
cord-311749-yp313biv	51	14	is	be	VBZ
cord-311749-yp313biv	51	15	increased	increase	VBN
cord-311749-yp313biv	51	16	in	in	IN
cord-311749-yp313biv	51	17	COVID-19	covid-19	NN
cord-311749-yp313biv	51	18	compared	compare	VBN
cord-311749-yp313biv	51	19	with	with	IN
cord-311749-yp313biv	51	20	healthy	healthy	JJ
cord-311749-yp313biv	51	21	controls	control	NNS
cord-311749-yp313biv	51	22	.	.	.
cord-311749-yp313biv	52	1	As	as	IN
cord-311749-yp313biv	52	2	IL-6	IL-6	NNP
cord-311749-yp313biv	52	3	levels	level	NNS
cord-311749-yp313biv	52	4	were	be	VBD
cord-311749-yp313biv	52	5	higher	high	JJR
cord-311749-yp313biv	52	6	in	in	IN
cord-311749-yp313biv	52	7	the	the	DT
cord-311749-yp313biv	52	8	more	more	RBR
cord-311749-yp313biv	52	9	severely	severely	RB
cord-311749-yp313biv	52	10	ill	ill	JJ
cord-311749-yp313biv	52	11	patients	patient	NNS
cord-311749-yp313biv	52	12	with	with	IN
cord-311749-yp313biv	52	13	COVID-19	COVID-19	NNP
cord-311749-yp313biv	52	14	,	,	,
cord-311749-yp313biv	52	15	interestingly	interestingly	RB
cord-311749-yp313biv	52	16	,	,	,
cord-311749-yp313biv	52	17	AAT	AAT	NNP
cord-311749-yp313biv	52	18	was	be	VBD
cord-311749-yp313biv	52	19	similarly	similarly	RB
cord-311749-yp313biv	52	20	increased	increase	VBN
cord-311749-yp313biv	52	21	,	,	,
cord-311749-yp313biv	52	22	and	and	CC
cord-311749-yp313biv	52	23	the	the	DT
cord-311749-yp313biv	52	24	authors	author	NNS
cord-311749-yp313biv	52	25	demonstrate	demonstrate	VBP
cord-311749-yp313biv	52	26	that	that	IN
cord-311749-yp313biv	52	27	positive	positive	JJ
cord-311749-yp313biv	52	28	outcomes	outcome	NNS
cord-311749-yp313biv	52	29	were	be	VBD
cord-311749-yp313biv	52	30	associated	associate	VBN
cord-311749-yp313biv	52	31	with	with	IN
cord-311749-yp313biv	52	32	a	a	DT
cord-311749-yp313biv	52	33	lower	low	JJR
cord-311749-yp313biv	52	34	IL-6	IL-6	NNP
cord-311749-yp313biv	52	35	relative	relative	NN
cord-311749-yp313biv	52	36	to	to	IN
cord-311749-yp313biv	52	37	AAT	AAT	NNP
cord-311749-yp313biv	52	38	.	.	.
cord-311749-yp313biv	53	1	The	the	DT
cord-311749-yp313biv	53	2	authors	author	NNS
cord-311749-yp313biv	53	3	interpret	interpret	VBP
cord-311749-yp313biv	53	4	this	this	DT
cord-311749-yp313biv	53	5	as	as	IN
cord-311749-yp313biv	53	6	meriting	merit	VBG
cord-311749-yp313biv	53	7	a	a	DT
cord-311749-yp313biv	53	8	trial	trial	NN
cord-311749-yp313biv	53	9	of	of	IN
cord-311749-yp313biv	53	10	AAT	AAT	NNP
cord-311749-yp313biv	53	11	supplementation	supplementation	NN
cord-311749-yp313biv	53	12	as	as	IN
cord-311749-yp313biv	53	13	AAT	AAT	NNP
cord-311749-yp313biv	53	14	modulates	modulate	VBZ
cord-311749-yp313biv	53	15	inflammatory	inflammatory	JJ
cord-311749-yp313biv	53	16	cytokine	cytokine	NN
cord-311749-yp313biv	53	17	production	production	NN
cord-311749-yp313biv	53	18	.	.	.
cord-311749-yp313biv	54	1	Nevertheless	nevertheless	RB
cord-311749-yp313biv	54	2	,	,	,
cord-311749-yp313biv	54	3	because	because	IN
cord-311749-yp313biv	54	4	the	the	DT
cord-311749-yp313biv	54	5	differences	difference	NNS
cord-311749-yp313biv	54	6	in	in	IN
cord-311749-yp313biv	54	7	IL-6	IL-6	NNP
cord-311749-yp313biv	54	8	:	:	:
cord-311749-yp313biv	54	9	AAT	AAT	NNP
cord-311749-yp313biv	54	10	ratios	ratio	NNS
cord-311749-yp313biv	54	11	are	be	VBP
cord-311749-yp313biv	54	12	primarily	primarily	RB
cord-311749-yp313biv	54	13	driven	drive	VBN
cord-311749-yp313biv	54	14	by	by	IN
cord-311749-yp313biv	54	15	high	high	JJ
cord-311749-yp313biv	54	16	IL-6	IL-6	NNP
cord-311749-yp313biv	54	17	,	,	,
cord-311749-yp313biv	54	18	directly	directly	RB
cord-311749-yp313biv	54	19	targeting	target	VBG
cord-311749-yp313biv	54	20	IL-6	IL-6	NNP
cord-311749-yp313biv	54	21	represents	represent	VBZ
cord-311749-yp313biv	54	22	an	an	DT
cord-311749-yp313biv	54	23	equally	equally	RB
cord-311749-yp313biv	54	24	logical	logical	JJ
cord-311749-yp313biv	54	25	strategy	strategy	NN
cord-311749-yp313biv	54	26	.	.	.
cord-311749-yp313biv	55	1	This	this	DT
cord-311749-yp313biv	55	2	work	work	NN
cord-311749-yp313biv	55	3	extends	extend	VBZ
cord-311749-yp313biv	55	4	the	the	DT
cord-311749-yp313biv	55	5	characterization	characterization	NN
cord-311749-yp313biv	55	6	of	of	IN
cord-311749-yp313biv	55	7	COVID-19	COVID-19	NNP
cord-311749-yp313biv	55	8	by	by	IN
cord-311749-yp313biv	55	9	proposing	propose	VBG
cord-311749-yp313biv	55	10	two	two	CD
cord-311749-yp313biv	55	11	novel	novel	JJ
cord-311749-yp313biv	55	12	potential	potential	JJ
cord-311749-yp313biv	55	13	targets	target	NNS
cord-311749-yp313biv	55	14	:	:	:
cord-311749-yp313biv	55	15	neutrophil	neutrophil	NN
cord-311749-yp313biv	55	16	metabolic	metabolic	JJ
cord-311749-yp313biv	55	17	reprogramming	reprogramming	NN
cord-311749-yp313biv	55	18	and	and	CC
cord-311749-yp313biv	55	19	a	a	DT
cord-311749-yp313biv	55	20	relative	relative	JJ
cord-311749-yp313biv	55	21	AAT	AAT	NNP
cord-311749-yp313biv	55	22	deficiency	deficiency	NN
cord-311749-yp313biv	55	23	.	.	.
cord-311749-yp313biv	56	1	There	there	EX
cord-311749-yp313biv	56	2	are	be	VBP
cord-311749-yp313biv	56	3	.500	.500	CD
cord-311749-yp313biv	56	4	therapeutic	therapeutic	JJ
cord-311749-yp313biv	56	5	trials	trial	NNS
cord-311749-yp313biv	56	6	in	in	IN
cord-311749-yp313biv	56	7	COVID-19	COVID-19	NNP
cord-311749-yp313biv	56	8	worldwide	worldwide	RB
cord-311749-yp313biv	56	9	,	,	,
cord-311749-yp313biv	56	10	and	and	CC
cord-311749-yp313biv	56	11	as	as	RB
cord-311749-yp313biv	56	12	recently	recently	RB
cord-311749-yp313biv	56	13	reviewed	review	VBN
cord-311749-yp313biv	56	14	in	in	IN
cord-311749-yp313biv	56	15	the	the	DT
cord-311749-yp313biv	56	16	Journal	Journal	NNP
cord-311749-yp313biv	56	17	(	(	-LRB-
cord-311749-yp313biv	56	18	12	12	CD
cord-311749-yp313biv	56	19	)	)	-RRB-
cord-311749-yp313biv	56	20	,	,	,
cord-311749-yp313biv	56	21	many	many	JJ
cord-311749-yp313biv	56	22	duplicate	duplicate	VBP
cord-311749-yp313biv	56	23	existing	exist	VBG
cord-311749-yp313biv	56	24	trials	trial	NNS
cord-311749-yp313biv	56	25	or	or	CC
cord-311749-yp313biv	56	26	have	have	VBP
cord-311749-yp313biv	56	27	limited	limit	VBN
cord-311749-yp313biv	56	28	mechanistic	mechanistic	JJ
cord-311749-yp313biv	56	29	work	work	NN
cord-311749-yp313biv	56	30	underpinning	underpin	VBG
cord-311749-yp313biv	56	31	their	-PRON-	PRP$
cord-311749-yp313biv	56	32	choice	choice	NN
cord-311749-yp313biv	56	33	of	of	IN
cord-311749-yp313biv	56	34	target	target	NN
cord-311749-yp313biv	56	35	or	or	CC
cord-311749-yp313biv	56	36	design	design	NN
cord-311749-yp313biv	56	37	.	.	.
cord-311749-yp313biv	57	1	Therefore	therefore	RB
cord-311749-yp313biv	57	2	,	,	,
cord-311749-yp313biv	57	3	studies	study	NNS
cord-311749-yp313biv	57	4	such	such	JJ
cord-311749-yp313biv	57	5	as	as	IN
cord-311749-yp313biv	57	6	that	that	DT
cord-311749-yp313biv	57	7	presented	present	VBN
cord-311749-yp313biv	57	8	here	here	RB
cord-311749-yp313biv	57	9	are	be	VBP
cord-311749-yp313biv	57	10	important	important	JJ
cord-311749-yp313biv	57	11	to	to	TO
cord-311749-yp313biv	57	12	validate	validate	VB
cord-311749-yp313biv	57	13	potential	potential	JJ
cord-311749-yp313biv	57	14	targets	target	NNS
cord-311749-yp313biv	57	15	before	before	IN
cord-311749-yp313biv	57	16	embarking	embark	VBG
cord-311749-yp313biv	57	17	on	on	IN
cord-311749-yp313biv	57	18	therapeutic	therapeutic	JJ
cord-311749-yp313biv	57	19	trials	trial	NNS
cord-311749-yp313biv	57	20	.	.	.
cord-311749-yp313biv	58	1	Demonstrating	demonstrate	VBG
cord-311749-yp313biv	58	2	a	a	DT
cord-311749-yp313biv	58	3	mortality	mortality	NN
cord-311749-yp313biv	58	4	benefit	benefit	NN
cord-311749-yp313biv	58	5	with	with	IN
cord-311749-yp313biv	58	6	dexamethasone	dexamethasone	NN
cord-311749-yp313biv	58	7	is	be	VBZ
cord-311749-yp313biv	58	8	a	a	DT
cord-311749-yp313biv	58	9	significant	significant	JJ
cord-311749-yp313biv	58	10	breakthrough	breakthrough	NN
cord-311749-yp313biv	58	11	in	in	IN
cord-311749-yp313biv	58	12	antiinflammatory	antiinflammatory	JJ
cord-311749-yp313biv	58	13	therapy	therapy	NN
cord-311749-yp313biv	58	14	for	for	IN
cord-311749-yp313biv	58	15	COVID-19	COVID-19	NNP
cord-311749-yp313biv	58	16	;	;	:
cord-311749-yp313biv	58	17	however	however	RB
cord-311749-yp313biv	58	18	,	,	,
cord-311749-yp313biv	58	19	the	the	DT
cord-311749-yp313biv	58	20	mortality	mortality	NN
cord-311749-yp313biv	58	21	rates	rate	NNS
cord-311749-yp313biv	58	22	of	of	IN
cord-311749-yp313biv	58	23	17.8	17.8	CD
cord-311749-yp313biv	58	24	%	%	NN
cord-311749-yp313biv	58	25	(	(	-LRB-
cord-311749-yp313biv	58	26	patients	patient	NNS
cord-311749-yp313biv	58	27	not	not	RB
cord-311749-yp313biv	58	28	requiring	require	VBG
cord-311749-yp313biv	58	29	oxygen	oxygen	NN
cord-311749-yp313biv	58	30	)	)	-RRB-
cord-311749-yp313biv	58	31	,	,	,
cord-311749-yp313biv	58	32	23.3	23.3	CD
cord-311749-yp313biv	58	33	%	%	NN
cord-311749-yp313biv	58	34	(	(	-LRB-
cord-311749-yp313biv	58	35	patients	patient	NNS
cord-311749-yp313biv	58	36	requiring	require	VBG
cord-311749-yp313biv	58	37	oxygen	oxygen	NN
cord-311749-yp313biv	58	38	)	)	-RRB-
cord-311749-yp313biv	58	39	and	and	CC
cord-311749-yp313biv	58	40	29.3	29.3	CD
cord-311749-yp313biv	58	41	%	%	NN
cord-311749-yp313biv	58	42	(	(	-LRB-
cord-311749-yp313biv	58	43	patients	patient	NNS
cord-311749-yp313biv	58	44	requiring	require	VBG
cord-311749-yp313biv	58	45	invasive	invasive	JJ
cord-311749-yp313biv	58	46	mechanical	mechanical	JJ
cord-311749-yp313biv	58	47	ventilation	ventilation	NN
cord-311749-yp313biv	58	48	)	)	-RRB-
cord-311749-yp313biv	58	49	remain	remain	VBP
cord-311749-yp313biv	58	50	high	high	JJ
cord-311749-yp313biv	58	51	,	,	,
cord-311749-yp313biv	58	52	and	and	CC
cord-311749-yp313biv	58	53	novel	novel	JJ
cord-311749-yp313biv	58	54	therapies	therapy	NNS
cord-311749-yp313biv	58	55	will	will	MD
cord-311749-yp313biv	58	56	be	be	VB
cord-311749-yp313biv	58	57	required	require	VBN
cord-311749-yp313biv	58	58	(	(	-LRB-
cord-311749-yp313biv	58	59	9	9	CD
cord-311749-yp313biv	58	60	)	)	-RRB-
cord-311749-yp313biv	58	61	.	.	.
cord-311749-yp313biv	59	1	How	how	WRB
cord-311749-yp313biv	59	2	should	should	MD
cord-311749-yp313biv	59	3	we	-PRON-	PRP
cord-311749-yp313biv	59	4	prioritize	prioritize	VB
cord-311749-yp313biv	59	5	?	?	.
cord-311749-yp313biv	60	1	Anti	Anti	NNP
cord-311749-yp313biv	60	2	-	-	NNP
cord-311749-yp313biv	60	3	IL-6	IL-6	NNP
cord-311749-yp313biv	60	4	(	(	-LRB-
cord-311749-yp313biv	60	5	such	such	JJ
cord-311749-yp313biv	60	6	as	as	IN
cord-311749-yp313biv	60	7	tocilizumab	tocilizumab	NNP
cord-311749-yp313biv	60	8	)	)	-RRB-
cord-311749-yp313biv	60	9	,	,	,
cord-311749-yp313biv	60	10	anti	anti	NNS
cord-311749-yp313biv	60	11	-	-	NNS
cord-311749-yp313biv	60	12	IL-1b	il-1b	JJ
cord-311749-yp313biv	60	13	(	(	-LRB-
cord-311749-yp313biv	60	14	such	such	JJ
cord-311749-yp313biv	60	15	as	as	IN
cord-311749-yp313biv	60	16	anakinra	anakinra	NNP
cord-311749-yp313biv	60	17	)	)	-RRB-
cord-311749-yp313biv	60	18	,	,	,
cord-311749-yp313biv	60	19	anti	anti	NNP
cord-311749-yp313biv	60	20	-	-	NNP
cord-311749-yp313biv	60	21	TNF	TNF	NNP
cord-311749-yp313biv	60	22	(	(	-LRB-
cord-311749-yp313biv	60	23	e.g.	e.g.	RB
cord-311749-yp313biv	60	24	,	,	,
cord-311749-yp313biv	60	25	infliximab	infliximab	NNP
cord-311749-yp313biv	60	26	)	)	-RRB-
cord-311749-yp313biv	60	27	,	,	,
cord-311749-yp313biv	60	28	IFN	IFN	NNP
cord-311749-yp313biv	60	29	,	,	,
cord-311749-yp313biv	60	30	or	or	CC
cord-311749-yp313biv	60	31	exogenous	exogenous	JJ
cord-311749-yp313biv	60	32	AAT	AAT	NNP
cord-311749-yp313biv	60	33	?	?	.
cord-311749-yp313biv	61	1	If	if	IN
cord-311749-yp313biv	61	2	the	the	DT
cord-311749-yp313biv	61	3	immune	immune	JJ
cord-311749-yp313biv	61	4	system	system	NN
cord-311749-yp313biv	61	5	has	have	VBZ
cord-311749-yp313biv	61	6	been	be	VBN
cord-311749-yp313biv	61	7	rewired	rewire	VBN
cord-311749-yp313biv	61	8	,	,	,
cord-311749-yp313biv	61	9	how	how	WRB
cord-311749-yp313biv	61	10	do	do	VBP
cord-311749-yp313biv	61	11	we	-PRON-	PRP
cord-311749-yp313biv	61	12	know	know	VB
cord-311749-yp313biv	61	13	which	which	WDT
cord-311749-yp313biv	61	14	wires	wire	NNS
cord-311749-yp313biv	61	15	to	to	TO
cord-311749-yp313biv	61	16	cut	cut	VB
cord-311749-yp313biv	61	17	?	?	.
cord-311749-yp313biv	62	1	Although	although	IN
cord-311749-yp313biv	62	2	many	many	JJ
cord-311749-yp313biv	62	3	more	more	JJR
cord-311749-yp313biv	62	4	trials	trial	NNS
cord-311749-yp313biv	62	5	will	will	MD
cord-311749-yp313biv	62	6	report	report	VB
cord-311749-yp313biv	62	7	in	in	IN
cord-311749-yp313biv	62	8	2020	2020	CD
cord-311749-yp313biv	62	9	,	,	,
cord-311749-yp313biv	62	10	the	the	DT
cord-311749-yp313biv	62	11	efficiency	efficiency	NN
cord-311749-yp313biv	62	12	of	of	IN
cord-311749-yp313biv	62	13	therapeutic	therapeutic	JJ
cord-311749-yp313biv	62	14	development	development	NN
cord-311749-yp313biv	62	15	for	for	IN
cord-311749-yp313biv	62	16	COVID-19	COVID-19	NNP
cord-311749-yp313biv	62	17	will	will	MD
cord-311749-yp313biv	62	18	require	require	VB
cord-311749-yp313biv	62	19	a	a	DT
cord-311749-yp313biv	62	20	means	means	NN
cord-311749-yp313biv	62	21	of	of	IN
cord-311749-yp313biv	62	22	prioritizing	prioritize	VBG
cord-311749-yp313biv	62	23	targets	target	NNS
cord-311749-yp313biv	62	24	or	or	CC
cord-311749-yp313biv	62	25	many	many	JJ
cord-311749-yp313biv	62	26	trials	trial	NNS
cord-311749-yp313biv	62	27	will	will	MD
cord-311749-yp313biv	62	28	never	never	RB
cord-311749-yp313biv	62	29	complete	complete	VB
cord-311749-yp313biv	62	30	.	.	.
cord-311749-yp313biv	63	1	In	in	IN
cord-311749-yp313biv	63	2	this	this	DT
cord-311749-yp313biv	63	3	respect	respect	NN
cord-311749-yp313biv	63	4	,	,	,
cord-311749-yp313biv	63	5	translational	translational	JJ
cord-311749-yp313biv	63	6	studies	study	NNS
cord-311749-yp313biv	63	7	such	such	JJ
cord-311749-yp313biv	63	8	as	as	IN
cord-311749-yp313biv	63	9	this	this	DT
cord-311749-yp313biv	63	10	,	,	,
cord-311749-yp313biv	63	11	in	in	IN
cord-311749-yp313biv	63	12	addition	addition	NN
cord-311749-yp313biv	63	13	to	to	IN
cord-311749-yp313biv	63	14	proofof	proofof	JJ
cord-311749-yp313biv	63	15	-	-	HYPH
cord-311749-yp313biv	63	16	concept	concept	NN
cord-311749-yp313biv	63	17	phase	phase	NN
cord-311749-yp313biv	63	18	2	2	CD
cord-311749-yp313biv	63	19	programs	program	NNS
cord-311749-yp313biv	63	20	such	such	JJ
cord-311749-yp313biv	63	21	as	as	IN
cord-311749-yp313biv	63	22	ACCORD	ACCORD	NNP
cord-311749-yp313biv	63	23	(	(	-LRB-
cord-311749-yp313biv	63	24	Accelerating	accelerate	VBG
cord-311749-yp313biv	63	25	COVID-19	COVID-19	NNP
cord-311749-yp313biv	63	26	Research	Research	NNP
cord-311749-yp313biv	63	27	and	and	CC
cord-311749-yp313biv	63	28	Development	Development	NNP
cord-311749-yp313biv	63	29	)	)	-RRB-
cord-311749-yp313biv	63	30	in	in	IN
cord-311749-yp313biv	63	31	the	the	DT
cord-311749-yp313biv	63	32	United	United	NNP
cord-311749-yp313biv	63	33	Kingdom	Kingdom	NNP
cord-311749-yp313biv	63	34	,	,	,
cord-311749-yp313biv	63	35	are	be	VBP
cord-311749-yp313biv	63	36	the	the	DT
cord-311749-yp313biv	63	37	key	key	NN
cord-311749-yp313biv	63	38	to	to	TO
cord-311749-yp313biv	63	39	rapidly	rapidly	RB
cord-311749-yp313biv	63	40	prioritize	prioritize	VB
cord-311749-yp313biv	63	41	or	or	CC
cord-311749-yp313biv	63	42	discard	discard	VB
cord-311749-yp313biv	63	43	potential	potential	JJ
cord-311749-yp313biv	63	44	therapies	therapy	NNS
cord-311749-yp313biv	63	45	(	(	-LRB-
cord-311749-yp313biv	63	46	16	16	CD
cord-311749-yp313biv	63	47	)	)	-RRB-
cord-311749-yp313biv	63	48	.	.	.
cord-311749-yp313biv	64	1	n	n	NNP
cord-311749-yp313biv	64	2	Serum	serum	NN
cord-311749-yp313biv	64	3	creatinine	creatinine	NN
cord-311749-yp313biv	64	4	(	(	-LRB-
cord-311749-yp313biv	64	5	SCr	SCr	NNP
cord-311749-yp313biv	64	6	)	)	-RRB-
cord-311749-yp313biv	64	7	has	have	VBZ
cord-311749-yp313biv	64	8	long	long	RB
cord-311749-yp313biv	64	9	been	be	VBN
cord-311749-yp313biv	64	10	known	know	VBN
cord-311749-yp313biv	64	11	to	to	TO
cord-311749-yp313biv	64	12	be	be	VB
cord-311749-yp313biv	64	13	an	an	DT
cord-311749-yp313biv	64	14	imperfect	imperfect	JJ
cord-311749-yp313biv	64	15	biomarker	biomarker	NN
cord-311749-yp313biv	64	16	of	of	IN
cord-311749-yp313biv	64	17	kidney	kidney	NN
cord-311749-yp313biv	64	18	function	function	NN
cord-311749-yp313biv	64	19	(	(	-LRB-
cord-311749-yp313biv	64	20	1	1	CD
cord-311749-yp313biv	64	21	)	)	-RRB-
cord-311749-yp313biv	64	22	.	.	.
cord-311749-yp313biv	65	1	Although	although	IN
cord-311749-yp313biv	65	2	consensus	consensus	NN
cord-311749-yp313biv	65	3	definitions	definition	NNS
cord-311749-yp313biv	65	4	of	of	IN
cord-311749-yp313biv	65	5	acute	acute	JJ
cord-311749-yp313biv	65	6	kidney	kidney	NN
cord-311749-yp313biv	65	7	injury	injury	NN
cord-311749-yp313biv	65	8	(	(	-LRB-
cord-311749-yp313biv	65	9	AKI	AKI	NNP
cord-311749-yp313biv	65	10	)	)	-RRB-
cord-311749-yp313biv	65	11	using	use	VBG
cord-311749-yp313biv	65	12	SCr	SCr	NNS
cord-311749-yp313biv	65	13	exist	exist	VBP
cord-311749-yp313biv	65	14	,	,	,
cord-311749-yp313biv	65	15	they	-PRON-	PRP
cord-311749-yp313biv	65	16	remain	remain	VBP
cord-311749-yp313biv	65	17	limited	limited	JJ
cord-311749-yp313biv	65	18	(	(	-LRB-
cord-311749-yp313biv	65	19	2	2	CD
cord-311749-yp313biv	65	20	)	)	-RRB-
cord-311749-yp313biv	65	21	.	.	.
cord-311749-yp313biv	66	1	More	more	RBR
cord-311749-yp313biv	66	2	specifically	specifically	RB
cord-311749-yp313biv	66	3	,	,	,
cord-311749-yp313biv	66	4	owing	owe	VBG
cord-311749-yp313biv	66	5	to	to	IN
cord-311749-yp313biv	66	6	the	the	DT
cord-311749-yp313biv	66	7	nature	nature	NN
cord-311749-yp313biv	66	8	of	of	IN
cord-311749-yp313biv	66	9	renal	renal	JJ
cord-311749-yp313biv	66	10	reserve	reserve	NN
cord-311749-yp313biv	66	11	,	,	,
cord-311749-yp313biv	66	12	it	-PRON-	PRP
cord-311749-yp313biv	66	13	often	often	RB
cord-311749-yp313biv	66	14	takes	take	VBZ
cord-311749-yp313biv	66	15	a	a	DT
cord-311749-yp313biv	66	16	significant	significant	JJ
cord-311749-yp313biv	66	17	amount	amount	NN
cord-311749-yp313biv	66	18	of	of	IN
cord-311749-yp313biv	66	19	(	(	-LRB-
cord-311749-yp313biv	66	20	tubular	tubular	JJ
cord-311749-yp313biv	66	21	)	)	-RRB-
cord-311749-yp313biv	66	22	injury	injury	NN
cord-311749-yp313biv	66	23	to	to	TO
cord-311749-yp313biv	66	24	translate	translate	VB
cord-311749-yp313biv	66	25	into	into	IN
cord-311749-yp313biv	66	26	a	a	DT
cord-311749-yp313biv	66	27	rise	rise	NN
cord-311749-yp313biv	66	28	in	in	IN
cord-311749-yp313biv	66	29	SCr	scr	NN
cord-311749-yp313biv	66	30	concentrations	concentration	NNS
cord-311749-yp313biv	66	31	from	from	IN
cord-311749-yp313biv	66	32	baseline	baseline	NN
cord-311749-yp313biv	66	33	(	(	-LRB-
cord-311749-yp313biv	66	34	3	3	CD
cord-311749-yp313biv	66	35	)	)	-RRB-
cord-311749-yp313biv	66	36	.	.	.
cord-311749-yp313biv	67	1	Over	over	IN
cord-311749-yp313biv	67	2	the	the	DT
cord-311749-yp313biv	67	3	last	last	JJ
cord-311749-yp313biv	67	4	decade	decade	NN
cord-311749-yp313biv	67	5	,	,	,
cord-311749-yp313biv	67	6	countless	countless	JJ
cord-311749-yp313biv	67	7	investigations	investigation	NNS
cord-311749-yp313biv	67	8	have	have	VBP
cord-311749-yp313biv	67	9	sought	seek	VBN
cord-311749-yp313biv	67	10	to	to	TO
cord-311749-yp313biv	67	11	discover	discover	VB
cord-311749-yp313biv	67	12	and	and	CC
cord-311749-yp313biv	67	13	validate	validate	VB
cord-311749-yp313biv	67	14	biomarkers	biomarker	NNS
cord-311749-yp313biv	67	15	of	of	IN
cord-311749-yp313biv	67	16	AKI	AKI	NNP
cord-311749-yp313biv	67	17	that	that	WDT
cord-311749-yp313biv	67	18	can	can	MD
cord-311749-yp313biv	67	19	identify	identify	VB
cord-311749-yp313biv	67	20	patients	patient	NNS
cord-311749-yp313biv	67	21	who	who	WP
cord-311749-yp313biv	67	22	have	have	VBP
cord-311749-yp313biv	67	23	early	early	JJ
cord-311749-yp313biv	67	24	kidney	kidney	NN
cord-311749-yp313biv	67	25	injury	injury	NN
cord-311749-yp313biv	67	26	(	(	-LRB-
cord-311749-yp313biv	67	27	4	4	CD
cord-311749-yp313biv	67	28	)	)	-RRB-
cord-311749-yp313biv	67	29	.	.	.
cord-311749-yp313biv	68	1	This	this	DT
cord-311749-yp313biv	68	2	concept	concept	NN
cord-311749-yp313biv	68	3	of	of	IN
cord-311749-yp313biv	68	4	elevation	elevation	NN
cord-311749-yp313biv	68	5	in	in	IN
cord-311749-yp313biv	68	6	kidney	kidney	NN
cord-311749-yp313biv	68	7	injury	injury	NN
cord-311749-yp313biv	68	8	biomarkers	biomarker	NNS
cord-311749-yp313biv	68	9	in	in	IN
cord-311749-yp313biv	68	10	the	the	DT
cord-311749-yp313biv	68	11	absence	absence	NN
cord-311749-yp313biv	68	12	of	of	IN
cord-311749-yp313biv	68	13	changes	change	NNS
cord-311749-yp313biv	68	14	in	in	IN
cord-311749-yp313biv	68	15	traditional	traditional	JJ
cord-311749-yp313biv	68	16	markers	marker	NNS
cord-311749-yp313biv	68	17	(	(	-LRB-
cord-311749-yp313biv	68	18	SCr	SCr	NNS
cord-311749-yp313biv	68	19	and	and	CC
cord-311749-yp313biv	68	20	urine	urine	NN
cord-311749-yp313biv	68	21	output	output	NN
cord-311749-yp313biv	68	22	[	[	-LRB-
cord-311749-yp313biv	68	23	UO	UO	NNP
cord-311749-yp313biv	68	24	]	]	-RRB-
cord-311749-yp313biv	68	25	)	)	-RRB-
cord-311749-yp313biv	68	26	has	have	VBZ
cord-311749-yp313biv	68	27	been	be	VBN
cord-311749-yp313biv	68	28	dubbed	dub	VBN
cord-311749-yp313biv	68	29	"	"	``
cord-311749-yp313biv	68	30	subclinical	subclinical	JJ
cord-311749-yp313biv	68	31	AKI	aki	NN
cord-311749-yp313biv	68	32	"	"	''
cord-311749-yp313biv	68	33	(	(	-LRB-
cord-311749-yp313biv	68	34	5	5	CD
cord-311749-yp313biv	68	35	)	)	-RRB-
cord-311749-yp313biv	68	36	.	.	.
cord-311749-yp313biv	69	1	However	however	RB
cord-311749-yp313biv	69	2	,	,	,
cord-311749-yp313biv	69	3	given	give	VBN
cord-311749-yp313biv	69	4	the	the	DT
cord-311749-yp313biv	69	5	mounting	mount	VBG
cord-311749-yp313biv	69	6	evidence	evidence	NN
cord-311749-yp313biv	69	7	and	and	CC
cord-311749-yp313biv	69	8	multiple	multiple	JJ
cord-311749-yp313biv	69	9	methods	method	NNS
cord-311749-yp313biv	69	10	of	of	IN
cord-311749-yp313biv	69	11	detecting	detect	VBG
cord-311749-yp313biv	69	12	this	this	DT
cord-311749-yp313biv	69	13	injury	injury	NN
cord-311749-yp313biv	69	14	,	,	,
cord-311749-yp313biv	69	15	perhaps	perhaps	RB
cord-311749-yp313biv	69	16	it	-PRON-	PRP
cord-311749-yp313biv	69	17	needs	need	VBZ
cord-311749-yp313biv	69	18	a	a	DT
cord-311749-yp313biv	69	19	different	different	JJ
cord-311749-yp313biv	69	20	name	name	NN
cord-311749-yp313biv	69	21	because	because	IN
cord-311749-yp313biv	69	22	it	-PRON-	PRP
cord-311749-yp313biv	69	23	will	will	MD
cord-311749-yp313biv	69	24	not	not	RB
cord-311749-yp313biv	69	25	be	be	VB
cord-311749-yp313biv	69	26	subclinical	subclinical	JJ
cord-311749-yp313biv	69	27	for	for	IN
cord-311749-yp313biv	69	28	much	much	RB
cord-311749-yp313biv	69	29	longer	long	JJR
cord-311749-yp313biv	69	30	.	.	.
cord-311749-yp313biv	70	1	It	-PRON-	PRP
cord-311749-yp313biv	70	2	is	be	VBZ
cord-311749-yp313biv	70	3	with	with	IN
cord-311749-yp313biv	70	4	this	this	DT
cord-311749-yp313biv	70	5	backdrop	backdrop	NN
cord-311749-yp313biv	70	6	that	that	IN
cord-311749-yp313biv	70	7	,	,	,
cord-311749-yp313biv	70	8	in	in	IN
cord-311749-yp313biv	70	9	this	this	DT
cord-311749-yp313biv	70	10	issue	issue	NN
cord-311749-yp313biv	70	11	of	of	IN
cord-311749-yp313biv	70	12	the	the	DT
cord-311749-yp313biv	70	13	Journal	Journal	NNP
cord-311749-yp313biv	70	14	,	,	,
cord-311749-yp313biv	70	15	Dépret	Dépret	NNP
cord-311749-yp313biv	70	16	and	and	CC
cord-311749-yp313biv	70	17	colleagues	colleague	NNS
cord-311749-yp313biv	70	18	(	(	-LRB-
cord-311749-yp313biv	70	19	pp	pp	NNP
cord-311749-yp313biv	70	20	.	.	.
cord-311749-yp313biv	70	21	822	822	CD
cord-311749-yp313biv	70	22	-	-	SYM
cord-311749-yp313biv	70	23	829	829	CD
cord-311749-yp313biv	70	24	)	)	-RRB-
cord-311749-yp313biv	70	25	investigated	investigate	VBN
cord-311749-yp313biv	70	26	plasma	plasma	NN
cord-311749-yp313biv	70	27	proenkephalin	proenkephalin	NNP
cord-311749-yp313biv	70	28	A	A	NNP
cord-311749-yp313biv	70	29	(	(	-LRB-
cord-311749-yp313biv	70	30	penKid	penKid	NNP
cord-311749-yp313biv	70	31	)	)	-RRB-
cord-311749-yp313biv	70	32	,	,	,
cord-311749-yp313biv	70	33	a	a	DT
cord-311749-yp313biv	70	34	5-kD	5-kd	CD
cord-311749-yp313biv	70	35	stable	stable	JJ
cord-311749-yp313biv	70	36	breakdown	breakdown	NN
cord-311749-yp313biv	70	37	product	product	NN
cord-311749-yp313biv	70	38	of	of	IN
cord-311749-yp313biv	70	39	enkephalins	enkephalin	NNS
cord-311749-yp313biv	70	40	that	that	WDT
cord-311749-yp313biv	70	41	accumulates	accumulate	VBZ
cord-311749-yp313biv	70	42	in	in	IN
cord-311749-yp313biv	70	43	the	the	DT
cord-311749-yp313biv	70	44	setting	setting	NN
cord-311749-yp313biv	70	45	of	of	IN
cord-311749-yp313biv	70	46	reduced	reduced	JJ
cord-311749-yp313biv	70	47	glomerular	glomerular	JJ
cord-311749-yp313biv	70	48	filtration	filtration	NN
cord-311749-yp313biv	70	49	(	(	-LRB-
cord-311749-yp313biv	70	50	GFR	GFR	NNP
cord-311749-yp313biv	70	51	)	)	-RRB-
cord-311749-yp313biv	70	52	as	as	IN
cord-311749-yp313biv	70	53	a	a	DT
cord-311749-yp313biv	70	54	biomarker	biomarker	NN
cord-311749-yp313biv	70	55	of	of	IN
cord-311749-yp313biv	70	56	subclinical	subclinical	JJ
cord-311749-yp313biv	70	57	AKI	AKI	NNP
cord-311749-yp313biv	70	58	in	in	IN
cord-311749-yp313biv	70	59	critically	critically	RB
cord-311749-yp313biv	70	60	ill	ill	JJ
cord-311749-yp313biv	70	61	patients	patient	NNS
cord-311749-yp313biv	70	62	(	(	-LRB-
cord-311749-yp313biv	70	63	6	6	CD
cord-311749-yp313biv	70	64	)	)	-RRB-
cord-311749-yp313biv	70	65	.	.	.
cord-311749-yp313biv	71	1	However	however	RB
cord-311749-yp313biv	71	2	,	,	,
cord-311749-yp313biv	71	3	this	this	DT
cord-311749-yp313biv	71	4	new	new	JJ
cord-311749-yp313biv	71	5	work	work	NN
cord-311749-yp313biv	71	6	is	be	VBZ
cord-311749-yp313biv	71	7	not	not	RB
cord-311749-yp313biv	71	8	the	the	DT
cord-311749-yp313biv	71	9	first	first	JJ
cord-311749-yp313biv	71	10	to	to	TO
cord-311749-yp313biv	71	11	look	look	VB
cord-311749-yp313biv	71	12	at	at	IN
cord-311749-yp313biv	71	13	subclinical	subclinical	JJ
cord-311749-yp313biv	71	14	AKI	AKI	NNP
cord-311749-yp313biv	71	15	;	;	:
cord-311749-yp313biv	71	16	in	in	IN
cord-311749-yp313biv	71	17	2011	2011	CD
cord-311749-yp313biv	71	18	,	,	,
cord-311749-yp313biv	71	19	Haase	Haase	NNP
cord-311749-yp313biv	71	20	and	and	CC
cord-311749-yp313biv	71	21	colleagues	colleague	NNS
cord-311749-yp313biv	71	22	published	publish	VBD
cord-311749-yp313biv	71	23	a	a	DT
cord-311749-yp313biv	71	24	pooled	pool	VBN
cord-311749-yp313biv	71	25	multicenter	multicenter	JJ
cord-311749-yp313biv	71	26	analysis	analysis	NN
cord-311749-yp313biv	71	27	of	of	IN
cord-311749-yp313biv	71	28	prospective	prospective	JJ
cord-311749-yp313biv	71	29	studies	study	NNS
cord-311749-yp313biv	71	30	focused	focus	VBN
cord-311749-yp313biv	71	31	on	on	IN
cord-311749-yp313biv	71	32	NGAL	NGAL	NNP
cord-311749-yp313biv	71	33	(	(	-LRB-
cord-311749-yp313biv	71	34	neutrophil	neutrophil	NNP
cord-311749-yp313biv	71	35	gelatinase	gelatinase	NN
cord-311749-yp313biv	71	36	-	-	HYPH
cord-311749-yp313biv	71	37	associated	associate	VBN
cord-311749-yp313biv	71	38	lipocalin	lipocalin	NNP
cord-311749-yp313biv	71	39	)	)	-RRB-
cord-311749-yp313biv	71	40	,	,	,
cord-311749-yp313biv	71	41	an	an	DT
cord-311749-yp313biv	71	42	iron	iron	NN
cord-311749-yp313biv	71	43	-	-	HYPH
cord-311749-yp313biv	71	44	binding	bind	VBG
cord-311749-yp313biv	71	45	protein	protein	NN
cord-311749-yp313biv	71	46	that	that	WDT
cord-311749-yp313biv	71	47	is	be	VBZ
cord-311749-yp313biv	71	48	upregulated	upregulate	VBN
cord-311749-yp313biv	71	49	in	in	IN
cord-311749-yp313biv	71	50	the	the	DT
cord-311749-yp313biv	71	51	setting	setting	NN
cord-311749-yp313biv	71	52	of	of	IN
cord-311749-yp313biv	71	53	ischemic	ischemic	JJ
cord-311749-yp313biv	71	54	kidney	kidney	NN
cord-311749-yp313biv	71	55	injury	injury	NN
cord-311749-yp313biv	71	56	(	(	-LRB-
cord-311749-yp313biv	71	57	7	7	CD
cord-311749-yp313biv	71	58	)	)	-RRB-
cord-311749-yp313biv	71	59	.	.	.
cord-311749-yp313biv	72	1	In	in	IN
cord-311749-yp313biv	72	2	a	a	DT
cord-311749-yp313biv	72	3	compilation	compilation	NN
cord-311749-yp313biv	72	4	of	of	IN
cord-311749-yp313biv	72	5	2,322	2,322	CD
cord-311749-yp313biv	72	6	critically	critically	RB
cord-311749-yp313biv	72	7	ill	ill	JJ
cord-311749-yp313biv	72	8	patients	patient	NNS
cord-311749-yp313biv	72	9	,	,	,
cord-311749-yp313biv	72	10	they	-PRON-	PRP
cord-311749-yp313biv	72	11	demonstrated	demonstrate	VBD
cord-311749-yp313biv	72	12	that	that	IN
cord-311749-yp313biv	72	13	patients	patient	NNS
cord-311749-yp313biv	72	14	who	who	WP
cord-311749-yp313biv	72	15	had	have	VBD
cord-311749-yp313biv	72	16	elevated	elevate	VBN
cord-311749-yp313biv	72	17	NGAL	NGAL	NNP
cord-311749-yp313biv	72	18	concentrations	concentration	NNS
cord-311749-yp313biv	72	19	in	in	IN
cord-311749-yp313biv	72	20	the	the	DT
cord-311749-yp313biv	72	21	absence	absence	NN
cord-311749-yp313biv	72	22	of	of	IN
cord-311749-yp313biv	72	23	changes	change	NNS
cord-311749-yp313biv	72	24	in	in	IN
cord-311749-yp313biv	72	25	SCr	SCr	NNS
cord-311749-yp313biv	72	26	(	(	-LRB-
cord-311749-yp313biv	72	27	NGAL	NGAL	NNP
cord-311749-yp313biv	72	28	[	[	-LRB-
cord-311749-yp313biv	72	29	1	1	CD
cord-311749-yp313biv	72	30	]	]	-RRB-
cord-311749-yp313biv	72	31	/SCr	/SCr	:
cord-311749-yp313biv	72	32	[	[	-LRB-
cord-311749-yp313biv	72	33	2	2	CD
cord-311749-yp313biv	72	34	]	]	-RRB-
cord-311749-yp313biv	72	35	)	)	-RRB-
cord-311749-yp313biv	72	36	had	have	VBD
cord-311749-yp313biv	72	37	similar	similar	JJ
cord-311749-yp313biv	72	38	outcomes	outcome	NNS
cord-311749-yp313biv	72	39	compared	compare	VBN
cord-311749-yp313biv	72	40	with	with	IN
cord-311749-yp313biv	72	41	those	those	DT
cord-311749-yp313biv	72	42	with	with	IN
cord-311749-yp313biv	72	43	elevations	elevation	NNS
cord-311749-yp313biv	72	44	in	in	IN
cord-311749-yp313biv	72	45	SCr	SCr	NNS
cord-311749-yp313biv	72	46	in	in	IN
cord-311749-yp313biv	72	47	the	the	DT
cord-311749-yp313biv	72	48	absence	absence	NN
cord-311749-yp313biv	72	49	of	of	IN
cord-311749-yp313biv	72	50	changes	change	NNS
cord-311749-yp313biv	72	51	in	in	IN
cord-311749-yp313biv	72	52	NGAL	NGAL	NNP
cord-311749-yp313biv	72	53	(	(	-LRB-
cord-311749-yp313biv	72	54	NGAL	NGAL	NNP
cord-311749-yp313biv	72	55	[	[	-LRB-
cord-311749-yp313biv	72	56	2	2	CD
cord-311749-yp313biv	72	57	]	]	-RRB-
cord-311749-yp313biv	73	1	/SCr	/SCr	NFP
cord-311749-yp313biv	73	2	[	[	-LRB-
cord-311749-yp313biv	73	3	1	1	CD
cord-311749-yp313biv	73	4	]	]	-RRB-
cord-311749-yp313biv	73	5	)	)	-RRB-
cord-311749-yp313biv	73	6	.	.	.
cord-311749-yp313biv	74	1	However	however	RB
cord-311749-yp313biv	74	2	,	,	,
cord-311749-yp313biv	74	3	both	both	CC
cord-311749-yp313biv	74	4	these	these	DT
cord-311749-yp313biv	74	5	groups	group	NNS
cord-311749-yp313biv	74	6	experienced	experience	VBD
cord-311749-yp313biv	74	7	more	more	RBR
cord-311749-yp313biv	74	8	adverse	adverse	JJ
cord-311749-yp313biv	74	9	outcomes	outcome	NNS
cord-311749-yp313biv	74	10	(	(	-LRB-
cord-311749-yp313biv	74	11	need	need	VBP
cord-311749-yp313biv	74	12	for	for	IN
cord-311749-yp313biv	74	13	renal	renal	JJ
cord-311749-yp313biv	74	14	replacement	replacement	NN
cord-311749-yp313biv	74	15	therapy	therapy	NN
cord-311749-yp313biv	74	16	,	,	,
cord-311749-yp313biv	74	17	longer	long	JJR
cord-311749-yp313biv	74	18	length	length	NN
cord-311749-yp313biv	74	19	of	of	IN
cord-311749-yp313biv	74	20	ICU	ICU	NNP
cord-311749-yp313biv	74	21	stay	stay	NN
cord-311749-yp313biv	74	22	,	,	,
cord-311749-yp313biv	74	23	and	and	CC
cord-311749-yp313biv	74	24	higher	high	JJR
cord-311749-yp313biv	74	25	inpatient	inpatient	JJ
cord-311749-yp313biv	74	26	mortality	mortality	NN
cord-311749-yp313biv	74	27	)	)	-RRB-
cord-311749-yp313biv	74	28	compared	compare	VBN
cord-311749-yp313biv	74	29	with	with	IN
cord-311749-yp313biv	74	30	those	those	DT
cord-311749-yp313biv	74	31	with	with	IN
cord-311749-yp313biv	74	32	no	no	DT
cord-311749-yp313biv	74	33	elevations	elevation	NNS
cord-311749-yp313biv	74	34	in	in	IN
cord-311749-yp313biv	74	35	SCr	SCr	NNS
cord-311749-yp313biv	74	36	or	or	CC
cord-311749-yp313biv	74	37	NGAL	NGAL	NNP
cord-311749-yp313biv	74	38	.	.	.
cord-311749-yp313biv	74	39	 	 	_SP
cord-311749-yp313biv	75	1	European	European	NNP
cord-311749-yp313biv	75	2	Centre	Centre	NNP
cord-311749-yp313biv	75	3	for	for	IN
cord-311749-yp313biv	75	4	Disease	Disease	NNP
cord-311749-yp313biv	75	5	Prevention	Prevention	NNP
cord-311749-yp313biv	75	6	and	and	CC
cord-311749-yp313biv	75	7	Control	Control	NNP
cord-311749-yp313biv	75	8	.	.	.
cord-311749-yp313biv	76	1	COVID-19	covid-19	JJ
cord-311749-yp313biv	76	2	pandemic	pandemic	JJ
cord-311749-yp313biv	76	3	Estimates	estimate	NNS
cord-311749-yp313biv	76	4	of	of	IN
cord-311749-yp313biv	76	5	the	the	DT
cord-311749-yp313biv	76	6	ongoing	ongoing	JJ
cord-311749-yp313biv	76	7	need	need	NN
cord-311749-yp313biv	76	8	for	for	IN
cord-311749-yp313biv	76	9	social	social	JJ
cord-311749-yp313biv	76	10	distancing	distancing	NN
cord-311749-yp313biv	76	11	and	and	CC
cord-311749-yp313biv	76	12	control	control	NN
cord-311749-yp313biv	76	13	measures	measure	NNS
cord-311749-yp313biv	76	14	post-"lockdown	post-"lockdown	XX
cord-311749-yp313biv	77	1	"	"	``
cord-311749-yp313biv	77	2	from	from	IN
cord-311749-yp313biv	77	3	trajectories	trajectory	NNS
cord-311749-yp313biv	77	4	of	of	IN
cord-311749-yp313biv	77	5	COVID-19	covid-19	JJ
cord-311749-yp313biv	77	6	cases	case	NNS
cord-311749-yp313biv	77	7	and	and	CC
cord-311749-yp313biv	77	8	mortality	mortality	NN
cord-311749-yp313biv	77	9	Rising	rise	VBG
cord-311749-yp313biv	77	10	to	to	IN
cord-311749-yp313biv	77	11	the	the	DT
cord-311749-yp313biv	77	12	challenge	challenge	NN
cord-311749-yp313biv	77	13	of	of	IN
cord-311749-yp313biv	77	14	COVID-19	COVID-19	NNP
cord-311749-yp313biv	77	15	:	:	:
cord-311749-yp313biv	77	16	advice	advice	NN
cord-311749-yp313biv	77	17	for	for	IN
cord-311749-yp313biv	77	18	pulmonary	pulmonary	JJ
cord-311749-yp313biv	77	19	and	and	CC
cord-311749-yp313biv	77	20	critical	critical	JJ
cord-311749-yp313biv	77	21	care	care	NN
cord-311749-yp313biv	77	22	and	and	CC
cord-311749-yp313biv	77	23	an	an	DT
cord-311749-yp313biv	77	24	agenda	agenda	NN
cord-311749-yp313biv	77	25	for	for	IN
cord-311749-yp313biv	77	26	research	research	NN
cord-311749-yp313biv	77	27	Centre	Centre	NNP
cord-311749-yp313biv	77	28	for	for	IN
cord-311749-yp313biv	77	29	the	the	DT
cord-311749-yp313biv	77	30	Mathematical	Mathematical	NNP
cord-311749-yp313biv	77	31	Modelling	Modelling	NNP
cord-311749-yp313biv	77	32	of	of	IN
cord-311749-yp313biv	77	33	Infectious	Infectious	NNP
cord-311749-yp313biv	77	34	Diseases	Diseases	NNPS
cord-311749-yp313biv	77	35	COVID-19	COVID-19	NNP
cord-311749-yp313biv	77	36	Working	Working	NNP
cord-311749-yp313biv	77	37	Group	Group	NNP
cord-311749-yp313biv	77	38	.	.	.
cord-311749-yp313biv	78	1	The	the	DT
cord-311749-yp313biv	78	2	effect	effect	NN
cord-311749-yp313biv	78	3	of	of	IN
cord-311749-yp313biv	78	4	control	control	NN
cord-311749-yp313biv	78	5	strategies	strategy	NNS
cord-311749-yp313biv	78	6	to	to	TO
cord-311749-yp313biv	78	7	reduce	reduce	VB
cord-311749-yp313biv	78	8	social	social	JJ
cord-311749-yp313biv	78	9	mixing	mixing	NN
cord-311749-yp313biv	78	10	on	on	IN
cord-311749-yp313biv	78	11	outcomes	outcome	NNS
cord-311749-yp313biv	78	12	of	of	IN
cord-311749-yp313biv	78	13	the	the	DT
cord-311749-yp313biv	78	14	COVID-19	covid-19	JJ
cord-311749-yp313biv	78	15	epidemic	epidemic	NN
cord-311749-yp313biv	78	16	in	in	IN
cord-311749-yp313biv	78	17	Wuhan	Wuhan	NNP
cord-311749-yp313biv	78	18	,	,	,
cord-311749-yp313biv	78	19	China	China	NNP
cord-311749-yp313biv	78	20	:	:	:
cord-311749-yp313biv	78	21	a	a	DT
cord-311749-yp313biv	78	22	modelling	modelling	NN
cord-311749-yp313biv	78	23	study	study	NN
cord-311749-yp313biv	78	24	Life	life	NN
cord-311749-yp313biv	78	25	at	at	IN
cord-311749-yp313biv	78	26	the	the	DT
cord-311749-yp313biv	78	27	editorial	editorial	NN
cord-311749-yp313biv	78	28	"	"	``
cord-311749-yp313biv	78	29	COVID	COVID	NNP
cord-311749-yp313biv	78	30	frontline	frontline	NNP
cord-311749-yp313biv	78	31	Prevention	Prevention	NNP
cord-311749-yp313biv	78	32	of	of	IN
cord-311749-yp313biv	78	33	the	the	DT
cord-311749-yp313biv	78	34	cytokine	cytokine	NN
cord-311749-yp313biv	78	35	storm	storm	NN
cord-311749-yp313biv	78	36	in	in	IN
cord-311749-yp313biv	78	37	COVID-19	COVID-19	NNP
cord-311749-yp313biv	78	38	Therapeutic	therapeutic	JJ
cord-311749-yp313biv	78	39	blockade	blockade	NN
cord-311749-yp313biv	78	40	of	of	IN
cord-311749-yp313biv	78	41	granulocyte	granulocyte	NN
cord-311749-yp313biv	78	42	macrophage	macrophage	NN
cord-311749-yp313biv	78	43	colonystimulating	colonystimulating	NN
cord-311749-yp313biv	78	44	factor	factor	NN
cord-311749-yp313biv	78	45	in	in	IN
cord-311749-yp313biv	78	46	COVID-19-associated	covid-19-associated	JJ
cord-311749-yp313biv	78	47	hyperinflammation	hyperinflammation	NN
cord-311749-yp313biv	78	48	:	:	:
cord-311749-yp313biv	78	49	challenges	challenge	NNS
cord-311749-yp313biv	78	50	and	and	CC
cord-311749-yp313biv	78	51	opportunities	opportunity	NNS
cord-311749-yp313biv	78	52	Clinical	clinical	JJ
cord-311749-yp313biv	78	53	course	course	NN
cord-311749-yp313biv	78	54	and	and	CC
cord-311749-yp313biv	78	55	risk	risk	NN
cord-311749-yp313biv	78	56	factors	factor	NNS
cord-311749-yp313biv	78	57	for	for	IN
cord-311749-yp313biv	78	58	mortality	mortality	NN
cord-311749-yp313biv	78	59	of	of	IN
cord-311749-yp313biv	78	60	adult	adult	NN
cord-311749-yp313biv	78	61	inpatients	inpatient	NNS
cord-311749-yp313biv	78	62	with	with	IN
cord-311749-yp313biv	78	63	COVID-19	COVID-19	NNP
cord-311749-yp313biv	78	64	in	in	IN
cord-311749-yp313biv	78	65	Wuhan	Wuhan	NNP
cord-311749-yp313biv	78	66	,	,	,
cord-311749-yp313biv	78	67	China	China	NNP
cord-311749-yp313biv	78	68	:	:	:
cord-311749-yp313biv	78	69	a	a	DT
cord-311749-yp313biv	78	70	retrospective	retrospective	JJ
cord-311749-yp313biv	78	71	cohort	cohort	NN
cord-311749-yp313biv	78	72	study	study	NN
cord-311749-yp313biv	78	73	RECOVERY	RECOVERY	NNP
cord-311749-yp313biv	78	74	Collaborative	Collaborative	NNP
cord-311749-yp313biv	78	75	Group	Group	NNP
cord-311749-yp313biv	78	76	.	.	.
cord-311749-yp313biv	79	1	Dexamethasone	Dexamethasone	NNP
cord-311749-yp313biv	79	2	in	in	IN
cord-311749-yp313biv	79	3	hospitalized	hospitalize	VBN
cord-311749-yp313biv	79	4	patients	patient	NNS
cord-311749-yp313biv	79	5	with	with	IN
cord-311749-yp313biv	79	6	Covid-19	Covid-19	NNP
cord-311749-yp313biv	79	7	-preliminary	-preliminary	JJ
cord-311749-yp313biv	79	8	report	report	NN
cord-311749-yp313biv	79	9	Severe	severe	JJ
cord-311749-yp313biv	79	10	immunosuppression	immunosuppression	NN
cord-311749-yp313biv	79	11	and	and	CC
cord-311749-yp313biv	79	12	not	not	RB
cord-311749-yp313biv	79	13	a	a	DT
cord-311749-yp313biv	79	14	cytokine	cytokine	NN
cord-311749-yp313biv	79	15	storm	storm	NN
cord-311749-yp313biv	79	16	characterize	characterize	VB
cord-311749-yp313biv	79	17	COVID-19	covid-19	CD
cord-311749-yp313biv	79	18	infections	infection	NNS
cord-311749-yp313biv	79	19	Impaired	impair	VBN
cord-311749-yp313biv	79	20	type	type	NN
cord-311749-yp313biv	80	1	I	-PRON-	PRP
cord-311749-yp313biv	80	2	interferon	interferon	VBD
cord-311749-yp313biv	80	3	activity	activity	NN
cord-311749-yp313biv	80	4	and	and	CC
cord-311749-yp313biv	80	5	inflammatory	inflammatory	JJ
cord-311749-yp313biv	80	6	responses	response	NNS
cord-311749-yp313biv	80	7	in	in	IN
cord-311749-yp313biv	80	8	severe	severe	JJ
cord-311749-yp313biv	80	9	COVID-19	COVID-19	NNP
cord-311749-yp313biv	80	10	patients	patient	NNS
cord-311749-yp313biv	80	11	COVID-19	covid-19	VBP
cord-311749-yp313biv	80	12	clinical	clinical	JJ
cord-311749-yp313biv	80	13	trials	trial	NNS
cord-311749-yp313biv	81	1	:	:	:
cord-311749-yp313biv	81	2	unravelling	unravel	VBG
cord-311749-yp313biv	81	3	a	a	DT
cord-311749-yp313biv	81	4	methodological	methodological	JJ
cord-311749-yp313biv	81	5	Gordian	gordian	JJ
cord-311749-yp313biv	81	6	knot	knot	NN
cord-311749-yp313biv	81	7	Neutrophil	Neutrophil	NNP
cord-311749-yp313biv	81	8	extracellular	extracellular	JJ
cord-311749-yp313biv	81	9	traps	trap	NNS
cord-311749-yp313biv	81	10	in	in	IN
cord-311749-yp313biv	81	11	COVID-19	COVID-19	NNP
cord-311749-yp313biv	81	12	Characterization	Characterization	NNP
cord-311749-yp313biv	81	13	of	of	IN
cord-311749-yp313biv	81	14	the	the	DT
cord-311749-yp313biv	81	15	inflammatory	inflammatory	JJ
cord-311749-yp313biv	81	16	response	response	NN
cord-311749-yp313biv	81	17	to	to	TO
cord-311749-yp313biv	81	18	severe	severe	JJ
cord-311749-yp313biv	81	19	COVID-19	covid-19	JJ
cord-311749-yp313biv	81	20	illness	illness	NN
cord-311749-yp313biv	81	21	Specific	specific	JJ
cord-311749-yp313biv	81	22	inhibition	inhibition	NN
cord-311749-yp313biv	81	23	of	of	IN
cord-311749-yp313biv	81	24	the	the	DT
cord-311749-yp313biv	81	25	NLRP3	NLRP3	NNP
cord-311749-yp313biv	81	26	inflammasome	inflammasome	NNP
cord-311749-yp313biv	81	27	as	as	IN
cord-311749-yp313biv	81	28	an	an	DT
cord-311749-yp313biv	81	29	antiinflammatory	antiinflammatory	JJ
cord-311749-yp313biv	81	30	strategy	strategy	NN
cord-311749-yp313biv	81	31	in	in	IN
cord-311749-yp313biv	81	32	cystic	cystic	JJ
cord-311749-yp313biv	81	33	fibrosis	fibrosis	NN
cord-311749-yp313biv	81	34	COVID-19	covid-19	CD
cord-311749-yp313biv	81	35	treatments	treatment	NNS
cord-311749-yp313biv	81	36	could	could	MD
cord-311749-yp313biv	81	37	be	be	VB
cord-311749-yp313biv	81	38	fast	fast	RB
cord-311749-yp313biv	81	39	-	-	HYPH
cord-311749-yp313biv	81	40	tracked	track	VBN
cord-311749-yp313biv	81	41	through	through	IN
cord-311749-yp313biv	81	42	new	new	JJ
cord-311749-yp313biv	81	43	national	national	JJ
cord-311749-yp313biv	81	44	clinical	clinical	JJ
cord-311749-yp313biv	81	45	trial	trial	NN
cord-311749-yp313biv	81	46	initiative	initiative	NN
cord-311749-yp313biv	81	47	.	.	.
cord-311749-yp313biv	82	1	Press	press	NN
cord-311749-yp313biv	82	2	release	release	NN
cord-311749-yp313biv	83	1	Subclinical	Subclinical	NNP
cord-311749-yp313biv	83	2	Acute	acute	JJ
cord-311749-yp313biv	83	3	Kidney	Kidney	NNP
cord-311749-yp313biv	83	4	Injury	injury	NN
cord-311749-yp313biv	83	5	Is	be	VBZ
cord-311749-yp313biv	83	6	Acute	acute	JJ
cord-311749-yp313biv	83	7	Kidney	kidney	NN
cord-311749-yp313biv	83	8	Injury	injury	NN
cord-311749-yp313biv	83	9	and	and	CC
cord-311749-yp313biv	83	10	Should	Should	MD
cord-311749-yp313biv	83	11	Not	not	RB
cord-311749-yp313biv	83	12	Be	be	VB
cord-311749-yp313biv	83	13	Ignored	ignore	VBN