id	sid	tid	token	lemma	pos
cord-307426-fkzk8ubd	1	1	key	key	NN
cord-307426-fkzk8ubd	1	2	:	:	:
cord-307426-fkzk8ubd	2	1	cord-307426-fkzk8ubd	cord-307426-fkzk8ubd	NN
cord-307426-fkzk8ubd	2	2	authors	author	NNS
cord-307426-fkzk8ubd	2	3	:	:	:
cord-307426-fkzk8ubd	2	4	Su	Su	NNP
cord-307426-fkzk8ubd	2	5	,	,	,
cord-307426-fkzk8ubd	3	1	Zheng	Zheng	NNP
cord-307426-fkzk8ubd	3	2	title	title	NN
cord-307426-fkzk8ubd	3	3	:	:	:
cord-307426-fkzk8ubd	4	1	The	the	DT
cord-307426-fkzk8ubd	4	2	Critical	critical	JJ
cord-307426-fkzk8ubd	4	3	Role	role	NN
cord-307426-fkzk8ubd	4	4	of	of	IN
cord-307426-fkzk8ubd	4	5	Futility	Futility	NNP
cord-307426-fkzk8ubd	4	6	Analysis	Analysis	NNP
cord-307426-fkzk8ubd	4	7	in	in	IN
cord-307426-fkzk8ubd	4	8	the	the	DT
cord-307426-fkzk8ubd	4	9	Pursuit	Pursuit	NNP
cord-307426-fkzk8ubd	4	10	of	of	IN
cord-307426-fkzk8ubd	4	11	Effective	Effective	NNP
cord-307426-fkzk8ubd	4	12	Treatments	Treatments	NNPS
cord-307426-fkzk8ubd	4	13	for	for	IN
cord-307426-fkzk8ubd	4	14	COVID-19	covid-19	CD
cord-307426-fkzk8ubd	4	15	date	date	NN
cord-307426-fkzk8ubd	4	16	:	:	:
cord-307426-fkzk8ubd	4	17	2020	2020	CD
cord-307426-fkzk8ubd	4	18	-	-	HYPH
cord-307426-fkzk8ubd	4	19	06	06	CD
cord-307426-fkzk8ubd	4	20	-	-	HYPH
cord-307426-fkzk8ubd	4	21	09	09	CD
cord-307426-fkzk8ubd	4	22	journal	journal	NN
cord-307426-fkzk8ubd	4	23	:	:	:
cord-307426-fkzk8ubd	5	1	Contemp	Contemp	NNP
cord-307426-fkzk8ubd	5	2	Clin	Clin	NNP
cord-307426-fkzk8ubd	5	3	Trials	Trials	NNPS
cord-307426-fkzk8ubd	5	4	Commun	Commun	NNP
cord-307426-fkzk8ubd	5	5	DOI	DOI	NNP
cord-307426-fkzk8ubd	5	6	:	:	:
cord-307426-fkzk8ubd	5	7	10.1016	10.1016	CD
cord-307426-fkzk8ubd	5	8	/	/	SYM
cord-307426-fkzk8ubd	5	9	j.conctc.2020.100581	j.conctc.2020.100581	NNP
cord-307426-fkzk8ubd	5	10	sha	sha	NNP
cord-307426-fkzk8ubd	5	11	:	:	:
cord-307426-fkzk8ubd	5	12	98bca73f00882a151f29cce93ebde6f6d5151163	98bca73f00882a151f29cce93ebde6f6d5151163	CD
cord-307426-fkzk8ubd	5	13	doc_id	doc_id	CD
cord-307426-fkzk8ubd	5	14	:	:	:
cord-307426-fkzk8ubd	5	15	307426	307426	CD
cord-307426-fkzk8ubd	5	16	cord_uid	cord_uid	NNS
cord-307426-fkzk8ubd	5	17	:	:	:
cord-307426-fkzk8ubd	5	18	fkzk8ubd	fkzk8ubd	NNP
cord-307426-fkzk8ubd	5	19	nan	nan	NNP
cord-307426-fkzk8ubd	6	1	The	the	DT
cord-307426-fkzk8ubd	6	2	potential	potential	NN
cord-307426-fkzk8ubd	6	3	to	to	TO
cord-307426-fkzk8ubd	6	4	stop	stop	VB
cord-307426-fkzk8ubd	6	5	a	a	DT
cord-307426-fkzk8ubd	6	6	trial	trial	NN
cord-307426-fkzk8ubd	6	7	or	or	CC
cord-307426-fkzk8ubd	6	8	some	some	DT
cord-307426-fkzk8ubd	6	9	of	of	IN
cord-307426-fkzk8ubd	6	10	the	the	DT
cord-307426-fkzk8ubd	6	11	treatment	treatment	NN
cord-307426-fkzk8ubd	6	12	arms	arm	NNS
cord-307426-fkzk8ubd	6	13	early	early	RB
cord-307426-fkzk8ubd	6	14	for	for	IN
cord-307426-fkzk8ubd	6	15	futility	futility	NN
cord-307426-fkzk8ubd	6	16	is	be	VBZ
cord-307426-fkzk8ubd	6	17	critical	critical	JJ
cord-307426-fkzk8ubd	6	18	in	in	IN
cord-307426-fkzk8ubd	6	19	the	the	DT
cord-307426-fkzk8ubd	6	20	pursuit	pursuit	NN
cord-307426-fkzk8ubd	6	21	of	of	IN
cord-307426-fkzk8ubd	6	22	effective	effective	JJ
cord-307426-fkzk8ubd	6	23	treatments	treatment	NNS
cord-307426-fkzk8ubd	6	24	for	for	IN
cord-307426-fkzk8ubd	6	25	COVID-19	covid-19	NN
cord-307426-fkzk8ubd	6	26	.	.	.
cord-307426-fkzk8ubd	7	1	A	a	DT
cord-307426-fkzk8ubd	7	2	large	large	JJ
cord-307426-fkzk8ubd	7	3	number	number	NN
cord-307426-fkzk8ubd	7	4	of	of	IN
cord-307426-fkzk8ubd	7	5	experimental	experimental	JJ
cord-307426-fkzk8ubd	7	6	treatments	treatment	NNS
cord-307426-fkzk8ubd	7	7	are	be	VBP
cord-307426-fkzk8ubd	7	8	being	be	VBG
cord-307426-fkzk8ubd	7	9	studied	study	VBN
cord-307426-fkzk8ubd	7	10	,	,	,
cord-307426-fkzk8ubd	7	11	and	and	CC
cord-307426-fkzk8ubd	7	12	it	-PRON-	PRP
cord-307426-fkzk8ubd	7	13	is	be	VBZ
cord-307426-fkzk8ubd	7	14	critical	critical	JJ
cord-307426-fkzk8ubd	7	15	to	to	TO
cord-307426-fkzk8ubd	7	16	be	be	VB
cord-307426-fkzk8ubd	7	17	able	able	JJ
cord-307426-fkzk8ubd	7	18	to	to	TO
cord-307426-fkzk8ubd	7	19	eliminate	eliminate	VB
cord-307426-fkzk8ubd	7	20	ineffective	ineffective	JJ
cord-307426-fkzk8ubd	7	21	treatments	treatment	NNS
cord-307426-fkzk8ubd	7	22	early	early	RB
cord-307426-fkzk8ubd	7	23	in	in	IN
cord-307426-fkzk8ubd	7	24	order	order	NN
cord-307426-fkzk8ubd	7	25	to	to	TO
cord-307426-fkzk8ubd	7	26	reallocate	reallocate	VB
cord-307426-fkzk8ubd	7	27	limited	limited	JJ
cord-307426-fkzk8ubd	7	28	resources	resource	NNS
cord-307426-fkzk8ubd	7	29	to	to	IN
cord-307426-fkzk8ubd	7	30	more	more	RBR
cord-307426-fkzk8ubd	7	31	promising	promising	JJ
cord-307426-fkzk8ubd	7	32	ones	one	NNS
cord-307426-fkzk8ubd	7	33	.	.	.
cord-307426-fkzk8ubd	8	1	Many	many	JJ
cord-307426-fkzk8ubd	8	2	of	of	IN
cord-307426-fkzk8ubd	8	3	the	the	DT
cord-307426-fkzk8ubd	8	4	experimental	experimental	JJ
cord-307426-fkzk8ubd	8	5	treatments	treatment	NNS
cord-307426-fkzk8ubd	8	6	under	under	IN
cord-307426-fkzk8ubd	8	7	testing	testing	NN
cord-307426-fkzk8ubd	8	8	for	for	IN
cord-307426-fkzk8ubd	8	9	COVID-19	COVID-19	NNP
cord-307426-fkzk8ubd	8	10	have	have	VBP
cord-307426-fkzk8ubd	8	11	limited	limit	VBN
cord-307426-fkzk8ubd	8	12	preclinical	preclinical	JJ
cord-307426-fkzk8ubd	8	13	and	and	CC
cord-307426-fkzk8ubd	8	14	clinical	clinical	JJ
cord-307426-fkzk8ubd	8	15	data	datum	NNS
cord-307426-fkzk8ubd	8	16	to	to	TO
cord-307426-fkzk8ubd	8	17	support	support	VB
cord-307426-fkzk8ubd	8	18	their	-PRON-	PRP$
cord-307426-fkzk8ubd	8	19	potential	potential	JJ
cord-307426-fkzk8ubd	8	20	effectiveness	effectiveness	NN
cord-307426-fkzk8ubd	8	21	.	.	.
cord-307426-fkzk8ubd	9	1	Various	various	JJ
cord-307426-fkzk8ubd	9	2	statistical	statistical	JJ
cord-307426-fkzk8ubd	9	3	methodologies	methodology	NNS
cord-307426-fkzk8ubd	9	4	exist	exist	VBP
cord-307426-fkzk8ubd	9	5	in	in	IN
cord-307426-fkzk8ubd	9	6	the	the	DT
cord-307426-fkzk8ubd	9	7	literature	literature	NN
cord-307426-fkzk8ubd	9	8	for	for	IN
cord-307426-fkzk8ubd	9	9	determining	determine	VBG
cord-307426-fkzk8ubd	9	10	the	the	DT
cord-307426-fkzk8ubd	9	11	futility	futility	NN
cord-307426-fkzk8ubd	9	12	stopping	stop	VBG
cord-307426-fkzk8ubd	9	13	criteria	criterion	NNS
cord-307426-fkzk8ubd	9	14	at	at	IN
cord-307426-fkzk8ubd	9	15	interim	interim	JJ
cord-307426-fkzk8ubd	9	16	analyses	analysis	NNS
cord-307426-fkzk8ubd	9	17	of	of	IN
cord-307426-fkzk8ubd	9	18	clinical	clinical	JJ
cord-307426-fkzk8ubd	9	19	trials	trial	NNS
cord-307426-fkzk8ubd	9	20	.	.	.
cord-307426-fkzk8ubd	10	1	For	for	IN
cord-307426-fkzk8ubd	10	2	example	example	NN
cord-307426-fkzk8ubd	10	3	,	,	,
cord-307426-fkzk8ubd	10	4	Pei	Pei	NNP
cord-307426-fkzk8ubd	10	5	et	et	NNP
cord-307426-fkzk8ubd	10	6	al	al	NNP
cord-307426-fkzk8ubd	10	7	.	.	.
cord-307426-fkzk8ubd	11	1	[	[	-LRB-
cord-307426-fkzk8ubd	11	2	2	2	CD
cord-307426-fkzk8ubd	11	3	]	]	-RRB-
cord-307426-fkzk8ubd	11	4	and	and	CC
cord-307426-fkzk8ubd	11	5	Yi	Yi	NNP
cord-307426-fkzk8ubd	11	6	et	et	FW
cord-307426-fkzk8ubd	11	7	al	al	NNP
cord-307426-fkzk8ubd	11	8	.	.	.
cord-307426-fkzk8ubd	12	1	[	[	-LRB-
cord-307426-fkzk8ubd	12	2	3	3	CD
cord-307426-fkzk8ubd	12	3	]	]	-RRB-
cord-307426-fkzk8ubd	12	4	reviewed	review	VBD
cord-307426-fkzk8ubd	12	5	some	some	DT
cord-307426-fkzk8ubd	12	6	methods	method	NNS
cord-307426-fkzk8ubd	12	7	based	base	VBN
cord-307426-fkzk8ubd	12	8	on	on	IN
cord-307426-fkzk8ubd	12	9	conditional	conditional	JJ
cord-307426-fkzk8ubd	12	10	power	power	NN
cord-307426-fkzk8ubd	12	11	and	and	CC
cord-307426-fkzk8ubd	12	12	predictive	predictive	JJ
cord-307426-fkzk8ubd	12	13	power	power	NN
cord-307426-fkzk8ubd	12	14	for	for	IN
cord-307426-fkzk8ubd	12	15	setting	set	VBG
cord-307426-fkzk8ubd	12	16	the	the	DT
cord-307426-fkzk8ubd	12	17	futility	futility	NN
cord-307426-fkzk8ubd	12	18	stopping	stop	VBG
cord-307426-fkzk8ubd	12	19	boundaries	boundary	NNS
cord-307426-fkzk8ubd	12	20	.	.	.
cord-307426-fkzk8ubd	13	1	A	a	DT
cord-307426-fkzk8ubd	13	2	randomized	randomized	JJ
cord-307426-fkzk8ubd	13	3	trial	trial	NN
cord-307426-fkzk8ubd	13	4	of	of	IN
cord-307426-fkzk8ubd	13	5	hydroxychloroquine	hydroxychloroquine	NN
cord-307426-fkzk8ubd	13	6	as	as	IN
cord-307426-fkzk8ubd	13	7	postexposure	postexposure	NN
cord-307426-fkzk8ubd	13	8	prophylaxis	prophylaxis	NN
cord-307426-fkzk8ubd	13	9	for	for	IN
cord-307426-fkzk8ubd	13	10	COVID-19	COVID-19	NNP
cord-307426-fkzk8ubd	13	11	was	be	VBD
cord-307426-fkzk8ubd	13	12	recently	recently	RB
cord-307426-fkzk8ubd	13	13	completed	complete	VBN
cord-307426-fkzk8ubd	13	14	,	,	,
cord-307426-fkzk8ubd	13	15	which	which	WDT
cord-307426-fkzk8ubd	13	16	demonstrated	demonstrate	VBD
cord-307426-fkzk8ubd	13	17	that	that	IN
cord-307426-fkzk8ubd	13	18	hydroxychloroquine	hydroxychloroquine	NNP
cord-307426-fkzk8ubd	13	19	did	do	VBD
cord-307426-fkzk8ubd	13	20	not	not	RB
cord-307426-fkzk8ubd	13	21	prevent	prevent	VB
cord-307426-fkzk8ubd	13	22	illness	illness	NN
cord-307426-fkzk8ubd	13	23	compatible	compatible	JJ
cord-307426-fkzk8ubd	13	24	with	with	IN
cord-307426-fkzk8ubd	13	25	COVID-19	COVID-19	NNP
cord-307426-fkzk8ubd	13	26	or	or	CC
cord-307426-fkzk8ubd	13	27	confirmed	confirm	VBN
cord-307426-fkzk8ubd	13	28	infection	infection	NN
cord-307426-fkzk8ubd	13	29	when	when	WRB
cord-307426-fkzk8ubd	13	30	used	use	VBN
cord-307426-fkzk8ubd	13	31	as	as	IN
cord-307426-fkzk8ubd	13	32	postexposure	postexposure	NN
cord-307426-fkzk8ubd	13	33	prophylaxis	prophylaxis	NN
cord-307426-fkzk8ubd	13	34	within	within	IN
cord-307426-fkzk8ubd	13	35	4	4	CD
cord-307426-fkzk8ubd	13	36	days	day	NNS
cord-307426-fkzk8ubd	13	37	after	after	IN
cord-307426-fkzk8ubd	13	38	exposure	exposure	NN
cord-307426-fkzk8ubd	13	39	[	[	-LRB-
cord-307426-fkzk8ubd	13	40	4	4	CD
cord-307426-fkzk8ubd	13	41	]	]	-RRB-
cord-307426-fkzk8ubd	13	42	.	.	.
cord-307426-fkzk8ubd	14	1	At	at	IN
cord-307426-fkzk8ubd	14	2	the	the	DT
cord-307426-fkzk8ubd	14	3	third	third	JJ
cord-307426-fkzk8ubd	14	4	interim	interim	JJ
cord-307426-fkzk8ubd	14	5	analysis	analysis	NN
cord-307426-fkzk8ubd	14	6	,	,	,
cord-307426-fkzk8ubd	14	7	this	this	DT
cord-307426-fkzk8ubd	14	8	trial	trial	NN
cord-307426-fkzk8ubd	14	9	was	be	VBD
cord-307426-fkzk8ubd	14	10	halted	halt	VBN
cord-307426-fkzk8ubd	14	11	for	for	IN
cord-307426-fkzk8ubd	14	12	futility	futility	NN
cord-307426-fkzk8ubd	14	13	on	on	IN
cord-307426-fkzk8ubd	14	14	the	the	DT
cord-307426-fkzk8ubd	14	15	basis	basis	NN
cord-307426-fkzk8ubd	14	16	of	of	IN
cord-307426-fkzk8ubd	14	17	a	a	DT
cord-307426-fkzk8ubd	14	18	conditional	conditional	JJ
cord-307426-fkzk8ubd	14	19	power	power	NN
cord-307426-fkzk8ubd	14	20	of	of	IN
cord-307426-fkzk8ubd	14	21	less	less	JJR
cord-307426-fkzk8ubd	14	22	than	than	IN
cord-307426-fkzk8ubd	14	23	1	1	CD
cord-307426-fkzk8ubd	14	24	%	%	NN
cord-307426-fkzk8ubd	14	25	.	.	.
cord-307426-fkzk8ubd	15	1	The	the	DT
cord-307426-fkzk8ubd	15	2	early	early	JJ
cord-307426-fkzk8ubd	15	3	futility	futility	NN
cord-307426-fkzk8ubd	15	4	stopping	stop	VBG
cord-307426-fkzk8ubd	15	5	of	of	IN
cord-307426-fkzk8ubd	15	6	the	the	DT
cord-307426-fkzk8ubd	15	7	trial	trial	NN
cord-307426-fkzk8ubd	15	8	provided	provide	VBD
cord-307426-fkzk8ubd	15	9	timely	timely	JJ
cord-307426-fkzk8ubd	15	10	information	information	NN
cord-307426-fkzk8ubd	15	11	on	on	IN
cord-307426-fkzk8ubd	15	12	the	the	DT
cord-307426-fkzk8ubd	15	13	potential	potential	NN
cord-307426-fkzk8ubd	15	14	of	of	IN
cord-307426-fkzk8ubd	15	15	hydroxychloroquine	hydroxychloroquine	NN
cord-307426-fkzk8ubd	15	16	as	as	IN
cord-307426-fkzk8ubd	15	17	postexposure	postexposure	NN
cord-307426-fkzk8ubd	15	18	prophylaxis	prophylaxis	NN
cord-307426-fkzk8ubd	15	19	at	at	IN
cord-307426-fkzk8ubd	15	20	a	a	DT
cord-307426-fkzk8ubd	15	21	time	time	NN
cord-307426-fkzk8ubd	15	22	when	when	WRB
cord-307426-fkzk8ubd	15	23	clarity	clarity	NN
cord-307426-fkzk8ubd	15	24	on	on	IN
cord-307426-fkzk8ubd	15	25	the	the	DT
cord-307426-fkzk8ubd	15	26	role	role	NN
cord-307426-fkzk8ubd	15	27	of	of	IN
cord-307426-fkzk8ubd	15	28	hydroxychloroquine	hydroxychloroquine	NN
cord-307426-fkzk8ubd	15	29	in	in	IN
cord-307426-fkzk8ubd	15	30	the	the	DT
cord-307426-fkzk8ubd	15	31	management	management	NN
cord-307426-fkzk8ubd	15	32	of	of	IN
cord-307426-fkzk8ubd	15	33	COVID-19	COVID-19	NNP
cord-307426-fkzk8ubd	15	34	was	be	VBD
cord-307426-fkzk8ubd	15	35	urgently	urgently	RB
cord-307426-fkzk8ubd	15	36	needed	need	VBN
cord-307426-fkzk8ubd	15	37	.	.	.
cord-307426-fkzk8ubd	16	1	It	-PRON-	PRP
cord-307426-fkzk8ubd	16	2	may	may	MD
cord-307426-fkzk8ubd	16	3	be	be	VB
cord-307426-fkzk8ubd	16	4	debatable	debatable	JJ
cord-307426-fkzk8ubd	16	5	whether	whether	IN
cord-307426-fkzk8ubd	16	6	adopting	adopt	VBG
cord-307426-fkzk8ubd	16	7	a	a	DT
cord-307426-fkzk8ubd	16	8	futility	futility	NN
cord-307426-fkzk8ubd	16	9	cutoff	cutoff	NN
cord-307426-fkzk8ubd	16	10	of	of	IN
cord-307426-fkzk8ubd	16	11	higher	high	JJR
cord-307426-fkzk8ubd	16	12	than	than	IN
cord-307426-fkzk8ubd	16	13	1	1	CD
cord-307426-fkzk8ubd	16	14	%	%	NN
cord-307426-fkzk8ubd	16	15	for	for	IN
cord-307426-fkzk8ubd	16	16	the	the	DT
cord-307426-fkzk8ubd	16	17	conditional	conditional	JJ
cord-307426-fkzk8ubd	16	18	power	power	NN
cord-307426-fkzk8ubd	16	19	could	could	MD
cord-307426-fkzk8ubd	16	20	have	have	VB
cord-307426-fkzk8ubd	16	21	led	lead	VBN
cord-307426-fkzk8ubd	16	22	to	to	IN
cord-307426-fkzk8ubd	16	23	earlier	early	RBR
cord-307426-fkzk8ubd	16	24	stopping	stop	VBG
cord-307426-fkzk8ubd	16	25	of	of	IN
cord-307426-fkzk8ubd	16	26	the	the	DT
cord-307426-fkzk8ubd	16	27	trial	trial	NN
cord-307426-fkzk8ubd	16	28	.	.	.
cord-307426-fkzk8ubd	17	1	The	the	DT
cord-307426-fkzk8ubd	17	2	RECOVERY	recovery	NN
cord-307426-fkzk8ubd	17	3	trial	trial	NN
cord-307426-fkzk8ubd	17	4	was	be	VBD
cord-307426-fkzk8ubd	17	5	launched	launch	VBN
cord-307426-fkzk8ubd	17	6	in	in	IN
cord-307426-fkzk8ubd	17	7	March	March	NNP
cord-307426-fkzk8ubd	17	8	to	to	TO
cord-307426-fkzk8ubd	17	9	test	test	VB
cord-307426-fkzk8ubd	17	10	several	several	JJ
cord-307426-fkzk8ubd	17	11	potential	potential	JJ
cord-307426-fkzk8ubd	17	12	treatments	treatment	NNS
cord-307426-fkzk8ubd	17	13	for	for	IN
cord-307426-fkzk8ubd	17	14	COVID-19	COVID-19	NNP
cord-307426-fkzk8ubd	17	15	,	,	,
cord-307426-fkzk8ubd	17	16	including	include	VBG
cord-307426-fkzk8ubd	17	17	hydroxychloroquine	hydroxychloroquine	NN
cord-307426-fkzk8ubd	17	18	[	[	-LRB-
cord-307426-fkzk8ubd	17	19	5	5	CD
cord-307426-fkzk8ubd	17	20	]	]	-RRB-
cord-307426-fkzk8ubd	17	21	.	.	.
cord-307426-fkzk8ubd	18	1	A	a	DT
cord-307426-fkzk8ubd	18	2	registry	registry	NN
cord-307426-fkzk8ubd	18	3	analysis	analysis	NN
cord-307426-fkzk8ubd	18	4	of	of	IN
cord-307426-fkzk8ubd	18	5	hydroxychloroquine	hydroxychloroquine	NN
cord-307426-fkzk8ubd	18	6	published	publish	VBN
cord-307426-fkzk8ubd	18	7	on	on	IN
cord-307426-fkzk8ubd	18	8	May	May	NNP
cord-307426-fkzk8ubd	18	9	22	22	CD
cord-307426-fkzk8ubd	18	10	,	,	,
cord-307426-fkzk8ubd	18	11	2020	2020	CD
cord-307426-fkzk8ubd	18	12	[	[	-LRB-
cord-307426-fkzk8ubd	18	13	6	6	CD
cord-307426-fkzk8ubd	18	14	]	]	-RRB-
cord-307426-fkzk8ubd	18	15	,	,	,
cord-307426-fkzk8ubd	18	16	which	which	WDT
cord-307426-fkzk8ubd	18	17	was	be	VBD
cord-307426-fkzk8ubd	18	18	later	later	RB
cord-307426-fkzk8ubd	18	19	retracted	retract	VBN
cord-307426-fkzk8ubd	18	20	,	,	,
cord-307426-fkzk8ubd	18	21	prompted	prompt	VBD
cord-307426-fkzk8ubd	18	22	the	the	DT
cord-307426-fkzk8ubd	18	23	independent	independent	NNP
cord-307426-fkzk8ubd	18	24	Data	Data	NNP
cord-307426-fkzk8ubd	18	25	Monitoring	Monitoring	NNP
cord-307426-fkzk8ubd	18	26	Committee	Committee	NNP
cord-307426-fkzk8ubd	18	27	(	(	-LRB-
cord-307426-fkzk8ubd	18	28	DMC	DMC	NNP
cord-307426-fkzk8ubd	18	29	)	)	-RRB-
cord-307426-fkzk8ubd	18	30	of	of	IN
cord-307426-fkzk8ubd	18	31	the	the	DT
cord-307426-fkzk8ubd	18	32	RECOVERY	recovery	NN
cord-307426-fkzk8ubd	18	33	trial	trial	NN
cord-307426-fkzk8ubd	18	34	to	to	TO
cord-307426-fkzk8ubd	18	35	conduct	conduct	VB
cord-307426-fkzk8ubd	18	36	an	an	DT
cord-307426-fkzk8ubd	18	37	urgent	urgent	JJ
cord-307426-fkzk8ubd	18	38	review	review	NN
cord-307426-fkzk8ubd	18	39	of	of	IN
cord-307426-fkzk8ubd	18	40	the	the	DT
cord-307426-fkzk8ubd	18	41	data	datum	NNS
cord-307426-fkzk8ubd	18	42	on	on	IN
cord-307426-fkzk8ubd	18	43	the	the	DT
cord-307426-fkzk8ubd	18	44	effects	effect	NNS
cord-307426-fkzk8ubd	18	45	of	of	IN
cord-307426-fkzk8ubd	18	46	hydroxychloroquine	hydroxychloroquine	NN
cord-307426-fkzk8ubd	18	47	on	on	IN
cord-307426-fkzk8ubd	18	48	mortality	mortality	NN
cord-307426-fkzk8ubd	18	49	among	among	IN
cord-307426-fkzk8ubd	18	50	hospitalized	hospitalize	VBN
cord-307426-fkzk8ubd	18	51	patients	patient	NNS
cord-307426-fkzk8ubd	18	52	with	with	IN
cord-307426-fkzk8ubd	18	53	COVID-19	COVID-19	NNP
cord-307426-fkzk8ubd	18	54	.	.	.
cord-307426-fkzk8ubd	19	1	The	the	DT
cord-307426-fkzk8ubd	19	2	committee	committee	NN
cord-307426-fkzk8ubd	19	3	concluded	conclude	VBD
cord-307426-fkzk8ubd	19	4	that	that	IN
cord-307426-fkzk8ubd	19	5	there	there	EX
cord-307426-fkzk8ubd	19	6	was	be	VBD
cord-307426-fkzk8ubd	19	7	no	no	DT
cord-307426-fkzk8ubd	19	8	cogent	cogent	JJ
cord-307426-fkzk8ubd	19	9	reason	reason	NN
cord-307426-fkzk8ubd	19	10	to	to	TO
cord-307426-fkzk8ubd	19	11	suspend	suspend	VB
cord-307426-fkzk8ubd	19	12	recruitment	recruitment	NN
cord-307426-fkzk8ubd	19	13	for	for	IN
cord-307426-fkzk8ubd	19	14	safety	safety	NN
cord-307426-fkzk8ubd	19	15	reasons	reason	NNS
cord-307426-fkzk8ubd	19	16	and	and	CC
cord-307426-fkzk8ubd	19	17	recommended	recommend	VBD
cord-307426-fkzk8ubd	19	18	that	that	IN
cord-307426-fkzk8ubd	19	19	the	the	DT
cord-307426-fkzk8ubd	19	20	trial	trial	NN
cord-307426-fkzk8ubd	19	21	continue	continue	VBP
cord-307426-fkzk8ubd	19	22	recruitment	recruitment	NN
cord-307426-fkzk8ubd	19	23	without	without	IN
cord-307426-fkzk8ubd	19	24	interruption	interruption	NN
cord-307426-fkzk8ubd	19	25	[	[	-LRB-
cord-307426-fkzk8ubd	19	26	7	7	CD
cord-307426-fkzk8ubd	19	27	]	]	-RRB-
cord-307426-fkzk8ubd	19	28	.	.	.
cord-307426-fkzk8ubd	20	1	On	on	IN
cord-307426-fkzk8ubd	20	2	June	June	NNP
cord-307426-fkzk8ubd	20	3	4	4	CD
cord-307426-fkzk8ubd	20	4	,	,	,
cord-307426-fkzk8ubd	20	5	2020	2020	CD
cord-307426-fkzk8ubd	20	6	,	,	,
cord-307426-fkzk8ubd	20	7	the	the	DT
cord-307426-fkzk8ubd	20	8	DMC	DMC	NNP
cord-307426-fkzk8ubd	20	9	conducted	conduct	VBD
cord-307426-fkzk8ubd	20	10	a	a	DT
cord-307426-fkzk8ubd	20	11	further	further	JJ
cord-307426-fkzk8ubd	20	12	review	review	NN
cord-307426-fkzk8ubd	20	13	of	of	IN
cord-307426-fkzk8ubd	20	14	the	the	DT
cord-307426-fkzk8ubd	20	15	data	datum	NNS
cord-307426-fkzk8ubd	20	16	,	,	,
cord-307426-fkzk8ubd	20	17	which	which	WDT
cord-307426-fkzk8ubd	20	18	led	lead	VBD
cord-307426-fkzk8ubd	20	19	to	to	IN
cord-307426-fkzk8ubd	20	20	the	the	DT
cord-307426-fkzk8ubd	20	21	conclusion	conclusion	NN
cord-307426-fkzk8ubd	20	22	of	of	IN
cord-307426-fkzk8ubd	20	23	no	no	DT
cord-307426-fkzk8ubd	20	24	beneficial	beneficial	JJ
cord-307426-fkzk8ubd	20	25	effect	effect	NN
cord-307426-fkzk8ubd	20	26	of	of	IN
cord-307426-fkzk8ubd	20	27	hydroxychloroquine	hydroxychloroquine	NN
cord-307426-fkzk8ubd	20	28	in	in	IN
cord-307426-fkzk8ubd	20	29	patients	patient	NNS
cord-307426-fkzk8ubd	20	30	hospitalized	hospitalize	VBN
cord-307426-fkzk8ubd	20	31	with	with	IN
cord-307426-fkzk8ubd	20	32	COVID-19	COVID-19	NNP
cord-307426-fkzk8ubd	20	33	and	and	CC
cord-307426-fkzk8ubd	20	34	the	the	DT
cord-307426-fkzk8ubd	20	35	decision	decision	NN
cord-307426-fkzk8ubd	20	36	to	to	TO
cord-307426-fkzk8ubd	20	37	stop	stop	VB
cord-307426-fkzk8ubd	20	38	enrolling	enrol	VBG
cord-307426-fkzk8ubd	20	39	patients	patient	NNS
cord-307426-fkzk8ubd	20	40	to	to	IN
cord-307426-fkzk8ubd	20	41	the	the	DT
cord-307426-fkzk8ubd	20	42	hydroxychloroquine	hydroxychloroquine	NN
cord-307426-fkzk8ubd	20	43	arm	arm	NN
cord-307426-fkzk8ubd	20	44	of	of	IN
cord-307426-fkzk8ubd	20	45	the	the	DT
cord-307426-fkzk8ubd	20	46	trial	trial	NN
cord-307426-fkzk8ubd	20	47	.	.	.
cord-307426-fkzk8ubd	21	1	A	a	DT
cord-307426-fkzk8ubd	21	2	total	total	NN
cord-307426-fkzk8ubd	21	3	of	of	IN
cord-307426-fkzk8ubd	21	4	1542	1542	CD
cord-307426-fkzk8ubd	21	5	patients	patient	NNS
cord-307426-fkzk8ubd	21	6	were	be	VBD
cord-307426-fkzk8ubd	21	7	randomized	randomize	VBN
cord-307426-fkzk8ubd	21	8	to	to	TO
cord-307426-fkzk8ubd	21	9	hydroxychloroquine	hydroxychloroquine	VB
cord-307426-fkzk8ubd	21	10	compared	compare	VBN
cord-307426-fkzk8ubd	21	11	with	with	IN
cord-307426-fkzk8ubd	21	12	3132	3132	CD
cord-307426-fkzk8ubd	21	13	patients	patient	NNS
cord-307426-fkzk8ubd	21	14	randomized	randomize	VBN
cord-307426-fkzk8ubd	21	15	to	to	IN
cord-307426-fkzk8ubd	21	16	usual	usual	JJ
cord-307426-fkzk8ubd	21	17	care	care	NN
cord-307426-fkzk8ubd	21	18	alone	alone	RB
cord-307426-fkzk8ubd	21	19	.	.	.
cord-307426-fkzk8ubd	22	1	There	there	EX
cord-307426-fkzk8ubd	22	2	was	be	VBD
cord-307426-fkzk8ubd	22	3	no	no	DT
cord-307426-fkzk8ubd	22	4	significant	significant	JJ
cord-307426-fkzk8ubd	22	5	difference	difference	NN
cord-307426-fkzk8ubd	22	6	in	in	IN
cord-307426-fkzk8ubd	22	7	the	the	DT
cord-307426-fkzk8ubd	22	8	primary	primary	JJ
cord-307426-fkzk8ubd	22	9	endpoint	endpoint	NN
cord-307426-fkzk8ubd	22	10	of	of	IN
cord-307426-fkzk8ubd	22	11	28-day	28-day	CD
cord-307426-fkzk8ubd	22	12	mortality	mortality	NN
cord-307426-fkzk8ubd	22	13	(	(	-LRB-
cord-307426-fkzk8ubd	22	14	25.7	25.7	CD
cord-307426-fkzk8ubd	22	15	%	%	NN
cord-307426-fkzk8ubd	22	16	hydroxychloroquine	hydroxychloroquine	NN
cord-307426-fkzk8ubd	22	17	vs.	vs.	CC
cord-307426-fkzk8ubd	22	18	23.5	23.5	CD
cord-307426-fkzk8ubd	22	19	%	%	NN
cord-307426-fkzk8ubd	22	20	usual	usual	JJ
cord-307426-fkzk8ubd	22	21	care	care	NN
cord-307426-fkzk8ubd	22	22	;	;	:
cord-307426-fkzk8ubd	22	23	hazard	hazard	NN
cord-307426-fkzk8ubd	22	24	ratio	ratio	NN
cord-307426-fkzk8ubd	22	25	1.11	1.11	CD
cord-307426-fkzk8ubd	22	26	[	[	-LRB-
cord-307426-fkzk8ubd	22	27	95	95	CD
cord-307426-fkzk8ubd	22	28	%	%	NN
cord-307426-fkzk8ubd	22	29	confidence	confidence	NN
cord-307426-fkzk8ubd	22	30	interval	interval	NN
cord-307426-fkzk8ubd	22	31	0.98	0.98	CD
cord-307426-fkzk8ubd	22	32	-	-	HYPH
cord-307426-fkzk8ubd	22	33	1.26	1.26	CD
cord-307426-fkzk8ubd	22	34	]	]	-RRB-
cord-307426-fkzk8ubd	22	35	;	;	:
cord-307426-fkzk8ubd	22	36	p=0.10	p=0.10	NNP
cord-307426-fkzk8ubd	22	37	)	)	-RRB-
cord-307426-fkzk8ubd	22	38	.	.	.
cord-307426-fkzk8ubd	23	1	There	there	EX
cord-307426-fkzk8ubd	23	2	was	be	VBD
cord-307426-fkzk8ubd	23	3	also	also	RB
cord-307426-fkzk8ubd	23	4	no	no	DT
cord-307426-fkzk8ubd	23	5	evidence	evidence	NN
cord-307426-fkzk8ubd	23	6	of	of	IN
cord-307426-fkzk8ubd	23	7	beneficial	beneficial	JJ
cord-307426-fkzk8ubd	23	8	effects	effect	NNS
cord-307426-fkzk8ubd	23	9	on	on	IN
cord-307426-fkzk8ubd	23	10	hospital	hospital	NN
cord-307426-fkzk8ubd	23	11	stay	stay	NN
cord-307426-fkzk8ubd	23	12	duration	duration	NN
cord-307426-fkzk8ubd	23	13	or	or	CC
cord-307426-fkzk8ubd	23	14	other	other	JJ
cord-307426-fkzk8ubd	23	15	outcomes	outcome	NNS
cord-307426-fkzk8ubd	23	16	[	[	-LRB-
cord-307426-fkzk8ubd	23	17	8	8	CD
cord-307426-fkzk8ubd	23	18	]	]	-RRB-
cord-307426-fkzk8ubd	23	19	.	.	.
cord-307426-fkzk8ubd	24	1	The	the	DT
cord-307426-fkzk8ubd	24	2	early	early	JJ
cord-307426-fkzk8ubd	24	3	termination	termination	NN
cord-307426-fkzk8ubd	24	4	of	of	IN
cord-307426-fkzk8ubd	24	5	the	the	DT
cord-307426-fkzk8ubd	24	6	hydroxychloroquine	hydroxychloroquine	NN
cord-307426-fkzk8ubd	24	7	arm	arm	NN
cord-307426-fkzk8ubd	24	8	was	be	VBD
cord-307426-fkzk8ubd	24	9	based	base	VBN
cord-307426-fkzk8ubd	24	10	on	on	IN
cord-307426-fkzk8ubd	24	11	data	datum	NNS
cord-307426-fkzk8ubd	24	12	from	from	IN
cord-307426-fkzk8ubd	24	13	over	over	IN
cord-307426-fkzk8ubd	24	14	4000	4000	CD
cord-307426-fkzk8ubd	24	15	patients	patient	NNS
cord-307426-fkzk8ubd	24	16	enrolled	enrol	VBN
cord-307426-fkzk8ubd	24	17	and	and	CC
cord-307426-fkzk8ubd	24	18	over	over	IN
cord-307426-fkzk8ubd	24	19	1000	1000	CD
cord-307426-fkzk8ubd	24	20	deaths	death	NNS
cord-307426-fkzk8ubd	24	21	observed	observe	VBN
cord-307426-fkzk8ubd	24	22	in	in	IN
cord-307426-fkzk8ubd	24	23	the	the	DT
cord-307426-fkzk8ubd	24	24	hydroxychloroquine	hydroxychloroquine	NN
cord-307426-fkzk8ubd	24	25	arm	arm	NN
cord-307426-fkzk8ubd	24	26	and	and	CC
cord-307426-fkzk8ubd	24	27	the	the	DT
cord-307426-fkzk8ubd	24	28	usual	usual	JJ
cord-307426-fkzk8ubd	24	29	care	care	NN
cord-307426-fkzk8ubd	24	30	arm	arm	NN
cord-307426-fkzk8ubd	24	31	combined	combine	VBN
cord-307426-fkzk8ubd	24	32	.	.	.
cord-307426-fkzk8ubd	25	1	The	the	DT
cord-307426-fkzk8ubd	25	2	28-day	28-day	CD
cord-307426-fkzk8ubd	25	3	mortality	mortality	NN
cord-307426-fkzk8ubd	25	4	rate	rate	NN
cord-307426-fkzk8ubd	25	5	was	be	VBD
cord-307426-fkzk8ubd	25	6	numerically	numerically	RB
cord-307426-fkzk8ubd	25	7	higher	high	JJR
cord-307426-fkzk8ubd	25	8	in	in	IN
cord-307426-fkzk8ubd	25	9	the	the	DT
cord-307426-fkzk8ubd	25	10	hydroxychloroquine	hydroxychloroquine	NN
cord-307426-fkzk8ubd	25	11	arm	arm	NN
cord-307426-fkzk8ubd	25	12	,	,	,
cord-307426-fkzk8ubd	25	13	and	and	CC
cord-307426-fkzk8ubd	25	14	the	the	DT
cord-307426-fkzk8ubd	25	15	lower	low	JJR
cord-307426-fkzk8ubd	25	16	limit	limit	NN
cord-307426-fkzk8ubd	25	17	of	of	IN
cord-307426-fkzk8ubd	25	18	the	the	DT
cord-307426-fkzk8ubd	25	19	95	95	CD
cord-307426-fkzk8ubd	25	20	%	%	NN
cord-307426-fkzk8ubd	25	21	confidence	confidence	NN
cord-307426-fkzk8ubd	25	22	interval	interval	NN
cord-307426-fkzk8ubd	25	23	for	for	IN
cord-307426-fkzk8ubd	25	24	the	the	DT
cord-307426-fkzk8ubd	25	25	hazard	hazard	NN
cord-307426-fkzk8ubd	25	26	ratio	ratio	NN
cord-307426-fkzk8ubd	25	27	convincingly	convincingly	RB
cord-307426-fkzk8ubd	25	28	ruled	rule	VBD
cord-307426-fkzk8ubd	25	29	out	out	RP
cord-307426-fkzk8ubd	25	30	any	any	DT
cord-307426-fkzk8ubd	25	31	meaningful	meaningful	JJ
cord-307426-fkzk8ubd	25	32	mortality	mortality	NN
cord-307426-fkzk8ubd	25	33	benefit	benefit	NN
cord-307426-fkzk8ubd	25	34	of	of	IN
cord-307426-fkzk8ubd	25	35	hydroxychloroquine	hydroxychloroquine	NN
cord-307426-fkzk8ubd	25	36	in	in	IN
cord-307426-fkzk8ubd	25	37	patients	patient	NNS
cord-307426-fkzk8ubd	25	38	hospitalized	hospitalize	VBN
cord-307426-fkzk8ubd	25	39	with	with	IN
cord-307426-fkzk8ubd	25	40	COVID-19	COVID-19	NNP
cord-307426-fkzk8ubd	25	41	.	.	.
cord-307426-fkzk8ubd	26	1	More	More	JJR
cord-307426-fkzk8ubd	26	2	details	detail	NNS
cord-307426-fkzk8ubd	26	3	on	on	IN
cord-307426-fkzk8ubd	26	4	the	the	DT
cord-307426-fkzk8ubd	26	5	interim	interim	JJ
cord-307426-fkzk8ubd	26	6	analyses	analysis	NNS
cord-307426-fkzk8ubd	26	7	conducted	conduct	VBN
cord-307426-fkzk8ubd	26	8	up	up	RP
cord-307426-fkzk8ubd	26	9	to	to	IN
cord-307426-fkzk8ubd	26	10	the	the	DT
cord-307426-fkzk8ubd	26	11	enrollment	enrollment	NN
cord-307426-fkzk8ubd	26	12	termination	termination	NN
cord-307426-fkzk8ubd	26	13	would	would	MD
cord-307426-fkzk8ubd	26	14	shed	shed	VB
cord-307426-fkzk8ubd	26	15	light	light	NN
cord-307426-fkzk8ubd	26	16	on	on	IN
cord-307426-fkzk8ubd	26	17	whether	whether	IN
cord-307426-fkzk8ubd	26	18	enrollment	enrollment	NN
cord-307426-fkzk8ubd	26	19	to	to	IN
cord-307426-fkzk8ubd	26	20	the	the	DT
cord-307426-fkzk8ubd	26	21	hydroxychloroquine	hydroxychloroquine	NN
cord-307426-fkzk8ubd	26	22	arm	arm	NN
cord-307426-fkzk8ubd	26	23	could	could	MD
cord-307426-fkzk8ubd	26	24	have	have	VB
cord-307426-fkzk8ubd	26	25	been	be	VBN
cord-307426-fkzk8ubd	26	26	stopped	stop	VBN
cord-307426-fkzk8ubd	26	27	earlier	early	RBR
cord-307426-fkzk8ubd	26	28	so	so	IN
cord-307426-fkzk8ubd	26	29	that	that	IN
cord-307426-fkzk8ubd	26	30	more	more	JJR
cord-307426-fkzk8ubd	26	31	patients	patient	NNS
cord-307426-fkzk8ubd	26	32	could	could	MD
cord-307426-fkzk8ubd	26	33	have	have	VB
cord-307426-fkzk8ubd	26	34	been	be	VBN
cord-307426-fkzk8ubd	26	35	allocated	allocate	VBN
cord-307426-fkzk8ubd	26	36	to	to	IN
cord-307426-fkzk8ubd	26	37	the	the	DT
cord-307426-fkzk8ubd	26	38	other	other	JJ
cord-307426-fkzk8ubd	26	39	treatment	treatment	NN
cord-307426-fkzk8ubd	26	40	arms	arm	NNS
cord-307426-fkzk8ubd	26	41	.	.	.
cord-307426-fkzk8ubd	27	1	Futility	futility	NN
cord-307426-fkzk8ubd	27	2	stopping	stop	VBG
cord-307426-fkzk8ubd	27	3	in	in	IN
cord-307426-fkzk8ubd	27	4	COVID-19	covid-19	JJ
cord-307426-fkzk8ubd	27	5	trials	trial	NNS
cord-307426-fkzk8ubd	27	6	deserves	deserve	VBZ
cord-307426-fkzk8ubd	27	7	special	special	JJ
cord-307426-fkzk8ubd	27	8	attention	attention	NN
cord-307426-fkzk8ubd	27	9	from	from	IN
cord-307426-fkzk8ubd	27	10	the	the	DT
cord-307426-fkzk8ubd	27	11	global	global	JJ
cord-307426-fkzk8ubd	27	12	clinical	clinical	JJ
cord-307426-fkzk8ubd	27	13	trials	trial	NNS
cord-307426-fkzk8ubd	27	14	community	community	NN
cord-307426-fkzk8ubd	27	15	.	.	.
cord-307426-fkzk8ubd	28	1	Trial	trial	NN
cord-307426-fkzk8ubd	28	2	sponsors	sponsor	NNS
cord-307426-fkzk8ubd	28	3	should	should	MD
cord-307426-fkzk8ubd	28	4	consider	consider	VB
cord-307426-fkzk8ubd	28	5	establishing	establish	VBG
cord-307426-fkzk8ubd	28	6	futility	futility	NN
cord-307426-fkzk8ubd	28	7	boundaries	boundary	NNS
cord-307426-fkzk8ubd	28	8	for	for	IN
cord-307426-fkzk8ubd	28	9	frequent	frequent	JJ
cord-307426-fkzk8ubd	28	10	interim	interim	JJ
cord-307426-fkzk8ubd	28	11	analyses	analysis	NNS
cord-307426-fkzk8ubd	28	12	based	base	VBN
cord-307426-fkzk8ubd	28	13	on	on	IN
cord-307426-fkzk8ubd	28	14	well	well	RB
cord-307426-fkzk8ubd	28	15	-	-	HYPH
cord-307426-fkzk8ubd	28	16	established	establish	VBN
cord-307426-fkzk8ubd	28	17	statistical	statistical	JJ
cord-307426-fkzk8ubd	28	18	methodologies	methodology	NNS
cord-307426-fkzk8ubd	28	19	.	.	.
cord-307426-fkzk8ubd	29	1	Institutional	Institutional	NNP
cord-307426-fkzk8ubd	29	2	Review	Review	NNP
cord-307426-fkzk8ubd	29	3	Boards	Boards	NNPS
cord-307426-fkzk8ubd	29	4	should	should	MD
cord-307426-fkzk8ubd	29	5	carefully	carefully	RB
cord-307426-fkzk8ubd	29	6	assess	assess	VB
cord-307426-fkzk8ubd	29	7	the	the	DT
cord-307426-fkzk8ubd	29	8	futility	futility	NN
cord-307426-fkzk8ubd	29	9	stopping	stop	VBG
cord-307426-fkzk8ubd	29	10	criteria	criterion	NNS
cord-307426-fkzk8ubd	29	11	and	and	CC
cord-307426-fkzk8ubd	29	12	the	the	DT
cord-307426-fkzk8ubd	29	13	frequency	frequency	NN
cord-307426-fkzk8ubd	29	14	of	of	IN
cord-307426-fkzk8ubd	29	15	interim	interim	JJ
cord-307426-fkzk8ubd	29	16	analyses	analysis	NNS
cord-307426-fkzk8ubd	29	17	during	during	IN
cord-307426-fkzk8ubd	29	18	the	the	DT
cord-307426-fkzk8ubd	29	19	protocol	protocol	NN
cord-307426-fkzk8ubd	29	20	review	review	NN
cord-307426-fkzk8ubd	29	21	process	process	NN
cord-307426-fkzk8ubd	29	22	.	.	.
cord-307426-fkzk8ubd	30	1	DMCs	DMCs	NNP
cord-307426-fkzk8ubd	30	2	should	should	MD
cord-307426-fkzk8ubd	30	3	consider	consider	VB
cord-307426-fkzk8ubd	30	4	making	make	VBG
cord-307426-fkzk8ubd	30	5	futility	futility	NN
cord-307426-fkzk8ubd	30	6	recommendations	recommendation	NNS
cord-307426-fkzk8ubd	30	7	based	base	VBN
cord-307426-fkzk8ubd	30	8	on	on	IN
cord-307426-fkzk8ubd	30	9	the	the	DT
cord-307426-fkzk8ubd	30	10	totality	totality	NN
cord-307426-fkzk8ubd	30	11	of	of	IN
cord-307426-fkzk8ubd	30	12	the	the	DT
cord-307426-fkzk8ubd	30	13	interim	interim	JJ
cord-307426-fkzk8ubd	30	14	data	datum	NNS
cord-307426-fkzk8ubd	30	15	irrespective	irrespective	RB
cord-307426-fkzk8ubd	30	16	of	of	IN
cord-307426-fkzk8ubd	30	17	the	the	DT
cord-307426-fkzk8ubd	30	18	futility	futility	NN
cord-307426-fkzk8ubd	30	19	boundaries	boundary	NNS
cord-307426-fkzk8ubd	30	20	specified	specify	VBN
cord-307426-fkzk8ubd	30	21	in	in	IN
cord-307426-fkzk8ubd	30	22	the	the	DT
cord-307426-fkzk8ubd	30	23	trial	trial	NN
cord-307426-fkzk8ubd	30	24	protocol	protocol	NN
cord-307426-fkzk8ubd	30	25	.	.	.
cord-307426-fkzk8ubd	31	1	In	in	IN
cord-307426-fkzk8ubd	31	2	addition	addition	NN
cord-307426-fkzk8ubd	31	3	,	,	,
cord-307426-fkzk8ubd	31	4	DMCs	DMCs	NNP
cord-307426-fkzk8ubd	31	5	should	should	MD
cord-307426-fkzk8ubd	31	6	consider	consider	VB
cord-307426-fkzk8ubd	31	7	reviewing	review	VBG
cord-307426-fkzk8ubd	31	8	interim	interim	JJ
cord-307426-fkzk8ubd	31	9	data	datum	NNS
cord-307426-fkzk8ubd	31	10	more	more	RBR
cord-307426-fkzk8ubd	31	11	frequently	frequently	RB
cord-307426-fkzk8ubd	31	12	than	than	IN
cord-307426-fkzk8ubd	31	13	specified	specify	VBN
cord-307426-fkzk8ubd	31	14	in	in	IN
cord-307426-fkzk8ubd	31	15	the	the	DT
cord-307426-fkzk8ubd	31	16	protocol	protocol	NN
cord-307426-fkzk8ubd	31	17	,	,	,
cord-307426-fkzk8ubd	31	18	and	and	CC
cord-307426-fkzk8ubd	31	19	consider	consider	VB
cord-307426-fkzk8ubd	31	20	adding	add	VBG
cord-307426-fkzk8ubd	31	21	additional	additional	JJ
cord-307426-fkzk8ubd	31	22	futility	futility	NN
cord-307426-fkzk8ubd	31	23	analyses	analysis	NNS
cord-307426-fkzk8ubd	31	24	when	when	WRB
cord-307426-fkzk8ubd	31	25	the	the	DT
cord-307426-fkzk8ubd	31	26	results	result	NNS
cord-307426-fkzk8ubd	31	27	at	at	IN
cord-307426-fkzk8ubd	31	28	a	a	DT
cord-307426-fkzk8ubd	31	29	pre	pre	JJ
cord-307426-fkzk8ubd	31	30	-	-	JJ
cord-307426-fkzk8ubd	31	31	specified	specified	JJ
cord-307426-fkzk8ubd	31	32	interim	interim	JJ
cord-307426-fkzk8ubd	31	33	analysis	analysis	NN
cord-307426-fkzk8ubd	31	34	are	be	VBP
cord-307426-fkzk8ubd	31	35	trending	trend	VBG
cord-307426-fkzk8ubd	31	36	towards	towards	IN
cord-307426-fkzk8ubd	31	37	futility	futility	NN
cord-307426-fkzk8ubd	31	38	instead	instead	RB
cord-307426-fkzk8ubd	31	39	of	of	IN
cord-307426-fkzk8ubd	31	40	waiting	wait	VBG
cord-307426-fkzk8ubd	31	41	for	for	IN
cord-307426-fkzk8ubd	31	42	the	the	DT
cord-307426-fkzk8ubd	31	43	next	next	JJ
cord-307426-fkzk8ubd	31	44	pre	pre	JJ
cord-307426-fkzk8ubd	31	45	-	-	JJ
cord-307426-fkzk8ubd	31	46	specified	specified	JJ
cord-307426-fkzk8ubd	31	47	analysis	analysis	NN
cord-307426-fkzk8ubd	31	48	.	.	.
cord-307426-fkzk8ubd	32	1	The	the	DT
cord-307426-fkzk8ubd	32	2	tradeoff	tradeoff	NN
cord-307426-fkzk8ubd	32	3	between	between	IN
cord-307426-fkzk8ubd	32	4	the	the	DT
cord-307426-fkzk8ubd	32	5	cost	cost	NN
cord-307426-fkzk8ubd	32	6	of	of	IN
cord-307426-fkzk8ubd	32	7	futility	futility	NN
cord-307426-fkzk8ubd	32	8	interim	interim	JJ
cord-307426-fkzk8ubd	32	9	monitoring	monitoring	NN
cord-307426-fkzk8ubd	32	10	,	,	,
cord-307426-fkzk8ubd	32	11	which	which	WDT
cord-307426-fkzk8ubd	32	12	is	be	VBZ
cord-307426-fkzk8ubd	32	13	a	a	DT
cord-307426-fkzk8ubd	32	14	slight	slight	JJ
cord-307426-fkzk8ubd	32	15	loss	loss	NN
cord-307426-fkzk8ubd	32	16	of	of	IN
cord-307426-fkzk8ubd	32	17	study	study	NN
cord-307426-fkzk8ubd	32	18	power	power	NN
cord-307426-fkzk8ubd	32	19	,	,	,
cord-307426-fkzk8ubd	32	20	and	and	CC
cord-307426-fkzk8ubd	32	21	allocating	allocate	VBG
cord-307426-fkzk8ubd	32	22	limited	limited	JJ
cord-307426-fkzk8ubd	32	23	resources	resource	NNS
cord-307426-fkzk8ubd	32	24	to	to	IN
cord-307426-fkzk8ubd	32	25	more	more	RBR
cord-307426-fkzk8ubd	32	26	promising	promising	JJ
cord-307426-fkzk8ubd	32	27	experimental	experimental	JJ
cord-307426-fkzk8ubd	32	28	treatments	treatment	NNS
cord-307426-fkzk8ubd	32	29	should	should	MD
cord-307426-fkzk8ubd	32	30	be	be	VB
cord-307426-fkzk8ubd	32	31	carefully	carefully	RB
cord-307426-fkzk8ubd	32	32	considered	consider	VBN
cord-307426-fkzk8ubd	32	33	by	by	IN
cord-307426-fkzk8ubd	32	34	the	the	DT
cord-307426-fkzk8ubd	32	35	study	study	NN
cord-307426-fkzk8ubd	32	36	sponsor	sponsor	NN
cord-307426-fkzk8ubd	32	37	,	,	,
cord-307426-fkzk8ubd	32	38	the	the	DT
cord-307426-fkzk8ubd	32	39	IRB	IRB	NNP
cord-307426-fkzk8ubd	32	40	and	and	CC
cord-307426-fkzk8ubd	32	41	the	the	DT
cord-307426-fkzk8ubd	32	42	DMC	DMC	NNP
cord-307426-fkzk8ubd	32	43	in	in	IN
cord-307426-fkzk8ubd	32	44	the	the	DT
cord-307426-fkzk8ubd	32	45	pursuit	pursuit	NN
cord-307426-fkzk8ubd	32	46	of	of	IN
cord-307426-fkzk8ubd	32	47	safe	safe	JJ
cord-307426-fkzk8ubd	32	48	and	and	CC
cord-307426-fkzk8ubd	32	49	effective	effective	JJ
cord-307426-fkzk8ubd	32	50	treatments	treatment	NNS
cord-307426-fkzk8ubd	32	51	for	for	IN
cord-307426-fkzk8ubd	32	52	COVID-19	covid-19	NN
cord-307426-fkzk8ubd	32	53	.	.	.
cord-307426-fkzk8ubd	33	1	Futility	futility	NN
cord-307426-fkzk8ubd	33	2	stopping	stop	VBG
cord-307426-fkzk8ubd	33	3	in	in	IN
cord-307426-fkzk8ubd	33	4	clinical	clinical	JJ
cord-307426-fkzk8ubd	33	5	trials	trial	NNS
cord-307426-fkzk8ubd	33	6	Hybridization	hybridization	NN
cord-307426-fkzk8ubd	33	7	of	of	IN
cord-307426-fkzk8ubd	33	8	conditional	conditional	JJ
cord-307426-fkzk8ubd	33	9	and	and	CC
cord-307426-fkzk8ubd	33	10	predictive	predictive	JJ
cord-307426-fkzk8ubd	33	11	power	power	NN
cord-307426-fkzk8ubd	33	12	for	for	IN
cord-307426-fkzk8ubd	33	13	futility	futility	NN
cord-307426-fkzk8ubd	33	14	assessment	assessment	NN
cord-307426-fkzk8ubd	33	15	in	in	IN
cord-307426-fkzk8ubd	33	16	sequential	sequential	JJ
cord-307426-fkzk8ubd	33	17	clinical	clinical	JJ
cord-307426-fkzk8ubd	33	18	trials	trial	NNS
cord-307426-fkzk8ubd	33	19	with	with	IN
cord-307426-fkzk8ubd	33	20	time	time	NN
cord-307426-fkzk8ubd	33	21	-	-	HYPH
cord-307426-fkzk8ubd	33	22	to	to	IN
cord-307426-fkzk8ubd	33	23	-	-	HYPH
cord-307426-fkzk8ubd	33	24	event	event	NN
cord-307426-fkzk8ubd	33	25	outcomes	outcome	NNS
cord-307426-fkzk8ubd	33	26	:	:	:
cord-307426-fkzk8ubd	33	27	a	a	DT
cord-307426-fkzk8ubd	33	28	resampling	resampling	NN
cord-307426-fkzk8ubd	33	29	approach	approach	NN
cord-307426-fkzk8ubd	33	30	A	a	DT
cord-307426-fkzk8ubd	33	31	randomized	randomized	JJ
cord-307426-fkzk8ubd	33	32	trial	trial	NN
cord-307426-fkzk8ubd	33	33	of	of	IN
cord-307426-fkzk8ubd	33	34	hydroxychloroquine	hydroxychloroquine	NN
cord-307426-fkzk8ubd	33	35	as	as	IN
cord-307426-fkzk8ubd	33	36	postexposure	postexposure	NN
cord-307426-fkzk8ubd	33	37	prophylaxis	prophylaxis	NN
cord-307426-fkzk8ubd	33	38	for	for	IN
cord-307426-fkzk8ubd	33	39	Covid-19	Covid-19	NNP
cord-307426-fkzk8ubd	33	40	Hydroxychloroquine	Hydroxychloroquine	NNP
cord-307426-fkzk8ubd	33	41	or	or	CC
cord-307426-fkzk8ubd	33	42	chloroquine	chloroquine	NN
cord-307426-fkzk8ubd	33	43	with	with	IN
cord-307426-fkzk8ubd	33	44	or	or	CC
cord-307426-fkzk8ubd	33	45	without	without	IN
cord-307426-fkzk8ubd	33	46	a	a	DT
cord-307426-fkzk8ubd	33	47	macrolide	macrolide	NN
cord-307426-fkzk8ubd	33	48	for	for	IN
cord-307426-fkzk8ubd	33	49	treatment	treatment	NN
cord-307426-fkzk8ubd	33	50	of	of	IN
cord-307426-fkzk8ubd	33	51	COVID-19	COVID-19	NNP
cord-307426-fkzk8ubd	33	52	:	:	:
cord-307426-fkzk8ubd	33	53	a	a	DT
cord-307426-fkzk8ubd	33	54	multinational	multinational	JJ
cord-307426-fkzk8ubd	33	55	registry	registry	NN
cord-307426-fkzk8ubd	33	56	analysis	analysis	NN