id	sid	tid	token	lemma	pos
cord-306414-2dv3qced	1	1	key	key	NN
cord-306414-2dv3qced	1	2	:	:	:
cord-306414-2dv3qced	2	1	cord-306414	cord-306414	JJ
cord-306414-2dv3qced	2	2	-	-	HYPH
cord-306414-2dv3qced	2	3	2dv3qced	2dv3qced	JJ
cord-306414-2dv3qced	2	4	authors	author	NNS
cord-306414-2dv3qced	2	5	:	:	:
cord-306414-2dv3qced	2	6	Gutierrez	Gutierrez	NNP
cord-306414-2dv3qced	2	7	,	,	,
cord-306414-2dv3qced	2	8	Lucas	Lucas	NNP
cord-306414-2dv3qced	2	9	;	;	:
cord-306414-2dv3qced	2	10	Beckford	Beckford	NNP
cord-306414-2dv3qced	2	11	,	,	,
cord-306414-2dv3qced	2	12	John	John	NNP
cord-306414-2dv3qced	2	13	;	;	:
cord-306414-2dv3qced	2	14	Alachkar	Alachkar	NNP
cord-306414-2dv3qced	2	15	,	,	,
cord-306414-2dv3qced	2	16	Houda	Houda	NNP
cord-306414-2dv3qced	2	17	title	title	NN
cord-306414-2dv3qced	2	18	:	:	:
cord-306414-2dv3qced	2	19	Deciphering	decipher	VBG
cord-306414-2dv3qced	2	20	the	the	DT
cord-306414-2dv3qced	2	21	TCR	TCR	NNP
cord-306414-2dv3qced	2	22	Repertoire	repertoire	NN
cord-306414-2dv3qced	2	23	to	to	TO
cord-306414-2dv3qced	2	24	Solve	solve	VB
cord-306414-2dv3qced	2	25	the	the	DT
cord-306414-2dv3qced	2	26	COVID-19	COVID-19	NNP
cord-306414-2dv3qced	2	27	Mystery	Mystery	NNP
cord-306414-2dv3qced	2	28	date	date	NN
cord-306414-2dv3qced	2	29	:	:	:
cord-306414-2dv3qced	2	30	2020	2020	CD
cord-306414-2dv3qced	2	31	-	-	HYPH
cord-306414-2dv3qced	2	32	06	06	CD
cord-306414-2dv3qced	2	33	-	-	SYM
cord-306414-2dv3qced	2	34	20	20	CD
cord-306414-2dv3qced	2	35	journal	journal	NN
cord-306414-2dv3qced	2	36	:	:	:
cord-306414-2dv3qced	3	1	Trends	Trends	NNPS
cord-306414-2dv3qced	3	2	Pharmacol	Pharmacol	NNP
cord-306414-2dv3qced	3	3	Sci	Sci	NNP
cord-306414-2dv3qced	3	4	DOI	DOI	NNP
cord-306414-2dv3qced	3	5	:	:	:
cord-306414-2dv3qced	4	1	10.1016/	10.1016/	CD
cord-306414-2dv3qced	5	1	j.tips.2020.06.001	j.tips.2020.06.001	XX
cord-306414-2dv3qced	6	1	sha	sha	NNP
cord-306414-2dv3qced	6	2	:	:	:
cord-306414-2dv3qced	7	1	ec1c38f0a33606901fa1ce7c1a231f5fde1e1629	ec1c38f0a33606901fa1ce7c1a231f5fde1e1629	NNP
cord-306414-2dv3qced	7	2	doc_id	doc_id	NNP
cord-306414-2dv3qced	7	3	:	:	:
cord-306414-2dv3qced	7	4	306414	306414	CD
cord-306414-2dv3qced	7	5	cord_uid	cord_uid	NN
cord-306414-2dv3qced	7	6	:	:	:
cord-306414-2dv3qced	8	1	2dv3qced	2dv3qced	NNP
cord-306414-2dv3qced	9	1	The	the	DT
cord-306414-2dv3qced	9	2	severe	severe	JJ
cord-306414-2dv3qced	9	3	acute	acute	JJ
cord-306414-2dv3qced	9	4	respiratory	respiratory	JJ
cord-306414-2dv3qced	9	5	syndrome	syndrome	NN
cord-306414-2dv3qced	9	6	coronavirus	coronavirus	NN
cord-306414-2dv3qced	9	7	2	2	CD
cord-306414-2dv3qced	10	1	(	(	-LRB-
cord-306414-2dv3qced	10	2	SARS	SARS	NNP
cord-306414-2dv3qced	10	3	-	-	HYPH
cord-306414-2dv3qced	10	4	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	10	5	)	)	-RRB-
cord-306414-2dv3qced	10	6	has	have	VBZ
cord-306414-2dv3qced	10	7	infected	infect	VBN
cord-306414-2dv3qced	10	8	several	several	JJ
cord-306414-2dv3qced	10	9	millions	million	NNS
cord-306414-2dv3qced	10	10	and	and	CC
cord-306414-2dv3qced	10	11	killed	kill	VBD
cord-306414-2dv3qced	10	12	more	more	JJR
cord-306414-2dv3qced	10	13	than	than	IN
cord-306414-2dv3qced	10	14	quarter	quarter	NN
cord-306414-2dv3qced	10	15	of	of	IN
cord-306414-2dv3qced	10	16	a	a	DT
cord-306414-2dv3qced	10	17	million	million	CD
cord-306414-2dv3qced	10	18	worldwide	worldwide	RB
cord-306414-2dv3qced	10	19	to	to	IN
cord-306414-2dv3qced	10	20	date	date	NN
cord-306414-2dv3qced	10	21	.	.	.
cord-306414-2dv3qced	11	1	Important	important	JJ
cord-306414-2dv3qced	11	2	questions	question	NNS
cord-306414-2dv3qced	11	3	have	have	VBP
cord-306414-2dv3qced	11	4	remained	remain	VBN
cord-306414-2dv3qced	11	5	unanswered	unanswered	JJ
cord-306414-2dv3qced	11	6	:	:	:
cord-306414-2dv3qced	11	7	why	why	WRB
cord-306414-2dv3qced	11	8	some	some	DT
cord-306414-2dv3qced	11	9	patients	patient	NNS
cord-306414-2dv3qced	11	10	develop	develop	VBP
cord-306414-2dv3qced	11	11	severe	severe	JJ
cord-306414-2dv3qced	11	12	disease	disease	NN
cord-306414-2dv3qced	11	13	,	,	,
cord-306414-2dv3qced	11	14	while	while	IN
cord-306414-2dv3qced	11	15	others	other	NNS
cord-306414-2dv3qced	11	16	do	do	VBP
cord-306414-2dv3qced	11	17	not	not	RB
cord-306414-2dv3qced	11	18	;	;	:
cord-306414-2dv3qced	11	19	and	and	CC
cord-306414-2dv3qced	11	20	what	what	WDT
cord-306414-2dv3qced	11	21	roles	role	NNS
cord-306414-2dv3qced	11	22	do	do	VBP
cord-306414-2dv3qced	11	23	genetic	genetic	JJ
cord-306414-2dv3qced	11	24	variabilities	variability	NNS
cord-306414-2dv3qced	11	25	play	play	VB
cord-306414-2dv3qced	11	26	in	in	IN
cord-306414-2dv3qced	11	27	the	the	DT
cord-306414-2dv3qced	11	28	individual	individual	JJ
cord-306414-2dv3qced	11	29	immune	immune	JJ
cord-306414-2dv3qced	11	30	response	response	NN
cord-306414-2dv3qced	11	31	to	to	IN
cord-306414-2dv3qced	11	32	this	this	DT
cord-306414-2dv3qced	11	33	viral	viral	JJ
cord-306414-2dv3qced	11	34	infection	infection	NN
cord-306414-2dv3qced	11	35	.	.	.
cord-306414-2dv3qced	12	1	Here	here	RB
cord-306414-2dv3qced	12	2	,	,	,
cord-306414-2dv3qced	12	3	we	-PRON-	PRP
cord-306414-2dv3qced	12	4	discuss	discuss	VBP
cord-306414-2dv3qced	12	5	the	the	DT
cord-306414-2dv3qced	12	6	critical	critical	JJ
cord-306414-2dv3qced	12	7	role	role	NN
cord-306414-2dv3qced	12	8	T	t	NN
cord-306414-2dv3qced	12	9	cells	cell	NNS
cord-306414-2dv3qced	12	10	play	play	VBP
cord-306414-2dv3qced	12	11	in	in	IN
cord-306414-2dv3qced	12	12	the	the	DT
cord-306414-2dv3qced	12	13	orchestration	orchestration	NN
cord-306414-2dv3qced	12	14	of	of	IN
cord-306414-2dv3qced	12	15	the	the	DT
cord-306414-2dv3qced	12	16	antiviral	antiviral	JJ
cord-306414-2dv3qced	12	17	response	response	NN
cord-306414-2dv3qced	12	18	underlying	underlie	VBG
cord-306414-2dv3qced	12	19	the	the	DT
cord-306414-2dv3qced	12	20	pathogenesis	pathogenesis	NN
cord-306414-2dv3qced	12	21	of	of	IN
cord-306414-2dv3qced	12	22	the	the	DT
cord-306414-2dv3qced	12	23	disease	disease	NN
cord-306414-2dv3qced	12	24	,	,	,
cord-306414-2dv3qced	12	25	COVID-19	COVID-19	NNP
cord-306414-2dv3qced	12	26	.	.	.
cord-306414-2dv3qced	13	1	We	-PRON-	PRP
cord-306414-2dv3qced	13	2	highlight	highlight	VBP
cord-306414-2dv3qced	13	3	the	the	DT
cord-306414-2dv3qced	13	4	scientific	scientific	JJ
cord-306414-2dv3qced	13	5	rationale	rationale	NN
cord-306414-2dv3qced	13	6	for	for	IN
cord-306414-2dv3qced	13	7	comprehensive	comprehensive	JJ
cord-306414-2dv3qced	13	8	and	and	CC
cord-306414-2dv3qced	13	9	longitudinal	longitudinal	JJ
cord-306414-2dv3qced	13	10	TCR	TCR	NNP
cord-306414-2dv3qced	13	11	analyses	analysis	NNS
cord-306414-2dv3qced	13	12	in	in	IN
cord-306414-2dv3qced	13	13	COVID-19	covid-19	NN
cord-306414-2dv3qced	13	14	and	and	CC
cord-306414-2dv3qced	13	15	reason	reason	NN
cord-306414-2dv3qced	13	16	that	that	DT
cord-306414-2dv3qced	13	17	analyzing	analyze	VBG
cord-306414-2dv3qced	13	18	TCR	TCR	NNP
cord-306414-2dv3qced	13	19	repertoire	repertoire	NN
cord-306414-2dv3qced	13	20	in	in	IN
cord-306414-2dv3qced	13	21	COVID-19	covid-19	JJ
cord-306414-2dv3qced	13	22	patients	patient	NNS
cord-306414-2dv3qced	13	23	would	would	MD
cord-306414-2dv3qced	13	24	reveal	reveal	VB
cord-306414-2dv3qced	13	25	important	important	JJ
cord-306414-2dv3qced	13	26	findings	finding	NNS
cord-306414-2dv3qced	13	27	that	that	WDT
cord-306414-2dv3qced	13	28	may	may	MD
cord-306414-2dv3qced	13	29	explain	explain	VB
cord-306414-2dv3qced	13	30	the	the	DT
cord-306414-2dv3qced	13	31	outcome	outcome	NN
cord-306414-2dv3qced	13	32	disparity	disparity	NN
cord-306414-2dv3qced	13	33	observed	observe	VBD
cord-306414-2dv3qced	13	34	in	in	IN
cord-306414-2dv3qced	13	35	these	these	DT
cord-306414-2dv3qced	13	36	patients	patient	NNS
cord-306414-2dv3qced	13	37	.	.	.
cord-306414-2dv3qced	14	1	Finally	finally	RB
cord-306414-2dv3qced	14	2	,	,	,
cord-306414-2dv3qced	14	3	we	-PRON-	PRP
cord-306414-2dv3qced	14	4	provide	provide	VBP
cord-306414-2dv3qced	14	5	a	a	DT
cord-306414-2dv3qced	14	6	framework	framework	NN
cord-306414-2dv3qced	14	7	describing	describe	VBG
cord-306414-2dv3qced	14	8	the	the	DT
cord-306414-2dv3qced	14	9	different	different	JJ
cord-306414-2dv3qced	14	10	strategies	strategy	NNS
cord-306414-2dv3qced	14	11	,	,	,
cord-306414-2dv3qced	14	12	the	the	DT
cord-306414-2dv3qced	14	13	advantages	advantage	NNS
cord-306414-2dv3qced	14	14	,	,	,
cord-306414-2dv3qced	14	15	and	and	CC
cord-306414-2dv3qced	14	16	the	the	DT
cord-306414-2dv3qced	14	17	challenges	challenge	NNS
cord-306414-2dv3qced	14	18	involved	involve	VBN
cord-306414-2dv3qced	14	19	in	in	IN
cord-306414-2dv3qced	14	20	obtaining	obtain	VBG
cord-306414-2dv3qced	14	21	useful	useful	JJ
cord-306414-2dv3qced	14	22	TCR	TCR	NNP
cord-306414-2dv3qced	14	23	repertoire	repertoire	NN
cord-306414-2dv3qced	14	24	data	datum	NNS
cord-306414-2dv3qced	14	25	to	to	TO
cord-306414-2dv3qced	14	26	advance	advance	VB
cord-306414-2dv3qced	14	27	our	-PRON-	PRP$
cord-306414-2dv3qced	14	28	fight	fight	NN
cord-306414-2dv3qced	14	29	against	against	IN
cord-306414-2dv3qced	14	30	COVID-19	COVID-19	NNP
cord-306414-2dv3qced	14	31	.	.	.
cord-306414-2dv3qced	15	1	T	t	NN
cord-306414-2dv3qced	15	2	cells	cell	NNS
cord-306414-2dv3qced	15	3	are	be	VBP
cord-306414-2dv3qced	15	4	crucial	crucial	JJ
cord-306414-2dv3qced	15	5	mediators	mediator	NNS
cord-306414-2dv3qced	15	6	of	of	IN
cord-306414-2dv3qced	15	7	antiviral	antiviral	JJ
cord-306414-2dv3qced	15	8	adaptive	adaptive	JJ
cord-306414-2dv3qced	15	9	immunity	immunity	NN
cord-306414-2dv3qced	15	10	and	and	CC
cord-306414-2dv3qced	15	11	delineating	delineate	VBG
cord-306414-2dv3qced	15	12	the	the	DT
cord-306414-2dv3qced	15	13	role	role	NN
cord-306414-2dv3qced	15	14	of	of	IN
cord-306414-2dv3qced	15	15	the	the	DT
cord-306414-2dv3qced	15	16	TCR	TCR	NNP
cord-306414-2dv3qced	15	17	repertoire	repertoire	NN
cord-306414-2dv3qced	15	18	in	in	IN
cord-306414-2dv3qced	15	19	the	the	DT
cord-306414-2dv3qced	15	20	context	context	NN
cord-306414-2dv3qced	15	21	of	of	IN
cord-306414-2dv3qced	16	1	SARS	SARS	NNP
cord-306414-2dv3qced	16	2	-	-	HYPH
cord-306414-2dv3qced	16	3	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	16	4	merits	merit	VBZ
cord-306414-2dv3qced	16	5	research	research	NN
cord-306414-2dv3qced	16	6	efforts	effort	NNS
cord-306414-2dv3qced	16	7	.	.	.
cord-306414-2dv3qced	17	1	The	the	DT
cord-306414-2dv3qced	17	2	TCR	TCR	NNP
cord-306414-2dv3qced	17	3	repertoire	repertoire	NN
cord-306414-2dv3qced	17	4	dynamics	dynamic	NNS
cord-306414-2dv3qced	17	5	,	,	,
cord-306414-2dv3qced	17	6	composition	composition	NN
cord-306414-2dv3qced	17	7	,	,	,
cord-306414-2dv3qced	17	8	and	and	CC
cord-306414-2dv3qced	17	9	diversity	diversity	NN
cord-306414-2dv3qced	17	10	are	be	VBP
cord-306414-2dv3qced	17	11	influenced	influence	VBN
cord-306414-2dv3qced	17	12	by	by	IN
cord-306414-2dv3qced	17	13	several	several	JJ
cord-306414-2dv3qced	17	14	intrinsic	intrinsic	JJ
cord-306414-2dv3qced	17	15	and	and	CC
cord-306414-2dv3qced	17	16	extrinsic	extrinsic	JJ
cord-306414-2dv3qced	17	17	factors	factor	NNS
cord-306414-2dv3qced	17	18	such	such	JJ
cord-306414-2dv3qced	17	19	as	as	IN
cord-306414-2dv3qced	17	20	aging	age	VBG
cord-306414-2dv3qced	17	21	,	,	,
cord-306414-2dv3qced	17	22	HLA	HLA	NNP
cord-306414-2dv3qced	17	23	genetic	genetic	JJ
cord-306414-2dv3qced	17	24	variabilities	variability	NNS
cord-306414-2dv3qced	17	25	,	,	,
cord-306414-2dv3qced	17	26	viral	viral	JJ
cord-306414-2dv3qced	17	27	infection	infection	NN
cord-306414-2dv3qced	17	28	,	,	,
cord-306414-2dv3qced	17	29	etc	etc	FW
cord-306414-2dv3qced	17	30	.	.	.
cord-306414-2dv3qced	18	1	The	the	DT
cord-306414-2dv3qced	18	2	architecture	architecture	NN
cord-306414-2dv3qced	18	3	of	of	IN
cord-306414-2dv3qced	18	4	the	the	DT
cord-306414-2dv3qced	18	5	TCR	TCR	NNP
cord-306414-2dv3qced	18	6	repertoire	repertoire	NN
cord-306414-2dv3qced	18	7	largely	largely	RB
cord-306414-2dv3qced	18	8	contributes	contribute	VBZ
cord-306414-2dv3qced	18	9	to	to	IN
cord-306414-2dv3qced	18	10	the	the	DT
cord-306414-2dv3qced	18	11	performance	performance	NN
cord-306414-2dv3qced	18	12	of	of	IN
cord-306414-2dv3qced	18	13	the	the	DT
cord-306414-2dv3qced	18	14	adaptive	adaptive	JJ
cord-306414-2dv3qced	18	15	immune	immune	JJ
cord-306414-2dv3qced	18	16	response	response	NN
cord-306414-2dv3qced	18	17	against	against	IN
cord-306414-2dv3qced	18	18	SARS	SARS	NNP
cord-306414-2dv3qced	18	19	-	-	HYPH
cord-306414-2dv3qced	18	20	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	18	21	.	.	.
cord-306414-2dv3qced	19	1	Advances	advance	NNS
cord-306414-2dv3qced	19	2	in	in	IN
cord-306414-2dv3qced	19	3	sequencing	sequence	VBG
cord-306414-2dv3qced	19	4	technologies	technology	NNS
cord-306414-2dv3qced	19	5	and	and	CC
cord-306414-2dv3qced	19	6	single	single	JJ
cord-306414-2dv3qced	19	7	-	-	HYPH
cord-306414-2dv3qced	19	8	cell	cell	NN
cord-306414-2dv3qced	19	9	immune	immune	NN
cord-306414-2dv3qced	19	10	profiling	profiling	NN
cord-306414-2dv3qced	19	11	can	can	MD
cord-306414-2dv3qced	19	12	be	be	VB
cord-306414-2dv3qced	19	13	leveraged	leverage	VBN
cord-306414-2dv3qced	19	14	to	to	TO
cord-306414-2dv3qced	19	15	monitor	monitor	VB
cord-306414-2dv3qced	19	16	adaptive	adaptive	JJ
cord-306414-2dv3qced	19	17	immune	immune	JJ
cord-306414-2dv3qced	19	18	responses	response	NNS
cord-306414-2dv3qced	19	19	in	in	IN
cord-306414-2dv3qced	19	20	COVID-19	covid-19	JJ
cord-306414-2dv3qced	19	21	patients	patient	NNS
cord-306414-2dv3qced	19	22	and	and	CC
cord-306414-2dv3qced	19	23	guide	guide	VB
cord-306414-2dv3qced	19	24	future	future	JJ
cord-306414-2dv3qced	19	25	SARS	SARS	NNP
cord-306414-2dv3qced	19	26	-	-	HYPH
cord-306414-2dv3qced	19	27	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	19	28	immunotherapy	immunotherapy	NN
cord-306414-2dv3qced	19	29	and	and	CC
cord-306414-2dv3qced	19	30	biomarker	biomarker	NN
cord-306414-2dv3qced	19	31	development	development	NN
cord-306414-2dv3qced	19	32	.	.	.
cord-306414-2dv3qced	20	1	exhibit	exhibit	NN
cord-306414-2dv3qced	20	2	increased	increase	VBN
cord-306414-2dv3qced	20	3	serum	serum	NN
cord-306414-2dv3qced	20	4	interleukin-6	interleukin-6	NNP
cord-306414-2dv3qced	20	5	(	(	-LRB-
cord-306414-2dv3qced	20	6	IL-6	IL-6	NNP
cord-306414-2dv3qced	20	7	)	)	-RRB-
cord-306414-2dv3qced	20	8	,	,	,
cord-306414-2dv3qced	20	9	tumor	tumor	NN
cord-306414-2dv3qced	20	10	necrosis	necrosis	NN
cord-306414-2dv3qced	20	11	factor	factor	NN
cord-306414-2dv3qced	20	12	-	-	HYPH
cord-306414-2dv3qced	20	13	α	α	NN
cord-306414-2dv3qced	20	14	(	(	-LRB-
cord-306414-2dv3qced	20	15	TNF	TNF	NNP
cord-306414-2dv3qced	20	16	-	-	HYPH
cord-306414-2dv3qced	20	17	α	α	NNP
cord-306414-2dv3qced	20	18	)	)	-RRB-
cord-306414-2dv3qced	20	19	,	,	,
cord-306414-2dv3qced	20	20	and	and	CC
cord-306414-2dv3qced	20	21	c	c	NN
cord-306414-2dv3qced	20	22	-	-	HYPH
cord-306414-2dv3qced	20	23	reactive	reactive	JJ
cord-306414-2dv3qced	20	24	protein	protein	NN
cord-306414-2dv3qced	20	25	.	.	.
cord-306414-2dv3qced	21	1	In	in	IN
cord-306414-2dv3qced	21	2	addition	addition	NN
cord-306414-2dv3qced	21	3	,	,	,
cord-306414-2dv3qced	21	4	patients	patient	NNS
cord-306414-2dv3qced	21	5	with	with	IN
cord-306414-2dv3qced	21	6	severe	severe	JJ
cord-306414-2dv3qced	21	7	disease	disease	NN
cord-306414-2dv3qced	21	8	display	display	NN
cord-306414-2dv3qced	21	9	high	high	JJ
cord-306414-2dv3qced	21	10	levels	level	NNS
cord-306414-2dv3qced	21	11	of	of	IN
cord-306414-2dv3qced	21	12	neutrophils	neutrophil	NNS
cord-306414-2dv3qced	21	13	combined	combine	VBN
cord-306414-2dv3qced	21	14	with	with	IN
cord-306414-2dv3qced	21	15	a	a	DT
cord-306414-2dv3qced	21	16	significant	significant	JJ
cord-306414-2dv3qced	21	17	decrease	decrease	NN
cord-306414-2dv3qced	21	18	in	in	IN
cord-306414-2dv3qced	21	19	total	total	JJ
cord-306414-2dv3qced	21	20	lymphocytes	lymphocyte	NNS
cord-306414-2dv3qced	21	21	[	[	-LRB-
cord-306414-2dv3qced	21	22	7	7	CD
cord-306414-2dv3qced	21	23	]	]	-RRB-
cord-306414-2dv3qced	21	24	.	.	.
cord-306414-2dv3qced	22	1	These	these	DT
cord-306414-2dv3qced	22	2	proinflammatory	proinflammatory	JJ
cord-306414-2dv3qced	22	3	immune	immune	NN
cord-306414-2dv3qced	22	4	features	feature	NNS
cord-306414-2dv3qced	22	5	were	be	VBD
cord-306414-2dv3qced	22	6	also	also	RB
cord-306414-2dv3qced	22	7	correlated	correlate	VBN
cord-306414-2dv3qced	22	8	with	with	IN
cord-306414-2dv3qced	22	9	disease	disease	NN
cord-306414-2dv3qced	22	10	severity	severity	NN
cord-306414-2dv3qced	22	11	and	and	CC
cord-306414-2dv3qced	22	12	death	death	NN
cord-306414-2dv3qced	22	13	[	[	-LRB-
cord-306414-2dv3qced	22	14	8	8	CD
cord-306414-2dv3qced	22	15	]	]	-RRB-
cord-306414-2dv3qced	22	16	[	[	-LRB-
cord-306414-2dv3qced	22	17	9	9	CD
cord-306414-2dv3qced	22	18	]	]	-RRB-
cord-306414-2dv3qced	22	19	[	[	-LRB-
cord-306414-2dv3qced	22	20	10	10	CD
cord-306414-2dv3qced	22	21	]	]	-RRB-
cord-306414-2dv3qced	22	22	.	.	.
cord-306414-2dv3qced	23	1	Recent	recent	JJ
cord-306414-2dv3qced	23	2	study	study	NN
cord-306414-2dv3qced	23	3	has	have	VBZ
cord-306414-2dv3qced	23	4	characterized	characterize	VBN
cord-306414-2dv3qced	23	5	bronchoalveolar	bronchoalveolar	JJ
cord-306414-2dv3qced	23	6	lavage	lavage	NN
cord-306414-2dv3qced	23	7	fluid	fluid	NN
cord-306414-2dv3qced	23	8	immune	immune	JJ
cord-306414-2dv3qced	23	9	cells	cell	NNS
cord-306414-2dv3qced	23	10	from	from	IN
cord-306414-2dv3qced	23	11	patients	patient	NNS
cord-306414-2dv3qced	23	12	with	with	IN
cord-306414-2dv3qced	23	13	varying	vary	VBG
cord-306414-2dv3qced	23	14	severity	severity	NN
cord-306414-2dv3qced	23	15	of	of	IN
cord-306414-2dv3qced	23	16	COVID-19	COVID-19	NNP
cord-306414-2dv3qced	23	17	and	and	CC
cord-306414-2dv3qced	23	18	from	from	IN
cord-306414-2dv3qced	23	19	healthy	healthy	JJ
cord-306414-2dv3qced	23	20	people	people	NNS
cord-306414-2dv3qced	23	21	by	by	IN
cord-306414-2dv3qced	23	22	using	use	VBG
cord-306414-2dv3qced	23	23	single	single	JJ
cord-306414-2dv3qced	23	24	-	-	HYPH
cord-306414-2dv3qced	23	25	cell	cell	NN
cord-306414-2dv3qced	23	26	RNA	rna	NN
cord-306414-2dv3qced	23	27	sequencing	sequencing	NN
cord-306414-2dv3qced	23	28	.	.	.
cord-306414-2dv3qced	24	1	The	the	DT
cord-306414-2dv3qced	24	2	bronchoalveolar	bronchoalveolar	JJ
cord-306414-2dv3qced	24	3	lavage	lavage	NN
cord-306414-2dv3qced	24	4	fluid	fluid	NN
cord-306414-2dv3qced	24	5	from	from	IN
cord-306414-2dv3qced	24	6	patients	patient	NNS
cord-306414-2dv3qced	24	7	with	with	IN
cord-306414-2dv3qced	24	8	severe	severe	JJ
cord-306414-2dv3qced	24	9	COVID-9	COVID-9	NNPS
cord-306414-2dv3qced	24	10	exhibited	exhibit	VBD
cord-306414-2dv3qced	24	11	high	high	JJ
cord-306414-2dv3qced	24	12	proinflammatory	proinflammatory	JJ
cord-306414-2dv3qced	24	13	monocyte	monocyte	NN
cord-306414-2dv3qced	24	14	-	-	HYPH
cord-306414-2dv3qced	24	15	derived	derive	VBN
cord-306414-2dv3qced	24	16	macrophages	macrophage	NNS
cord-306414-2dv3qced	24	17	,	,	,
cord-306414-2dv3qced	24	18	while	while	IN
cord-306414-2dv3qced	24	19	moderate	moderate	JJ
cord-306414-2dv3qced	24	20	cases	case	NNS
cord-306414-2dv3qced	24	21	were	be	VBD
cord-306414-2dv3qced	24	22	characterized	characterize	VBN
cord-306414-2dv3qced	24	23	by	by	IN
cord-306414-2dv3qced	24	24	the	the	DT
cord-306414-2dv3qced	24	25	presence	presence	NN
cord-306414-2dv3qced	24	26	of	of	IN
cord-306414-2dv3qced	24	27	highly	highly	RB
cord-306414-2dv3qced	24	28	clonally	clonally	RB
cord-306414-2dv3qced	24	29	expanded	expand	VBN
cord-306414-2dv3qced	24	30	CD8	CD8	NNP
cord-306414-2dv3qced	24	31	+	+	CC
cord-306414-2dv3qced	24	32	T	T	NNP
cord-306414-2dv3qced	24	33	cells	cell	NNS
cord-306414-2dv3qced	24	34	[	[	-LRB-
cord-306414-2dv3qced	24	35	11	11	CD
cord-306414-2dv3qced	24	36	]	]	-RRB-
cord-306414-2dv3qced	24	37	.	.	.
cord-306414-2dv3qced	25	1	Yet	yet	RB
cord-306414-2dv3qced	25	2	,	,	,
cord-306414-2dv3qced	25	3	many	many	JJ
cord-306414-2dv3qced	25	4	important	important	JJ
cord-306414-2dv3qced	25	5	questions	question	NNS
cord-306414-2dv3qced	25	6	remained	remain	VBD
cord-306414-2dv3qced	25	7	unanswered	unanswered	JJ
cord-306414-2dv3qced	25	8	:	:	:
cord-306414-2dv3qced	25	9	why	why	WRB
cord-306414-2dv3qced	25	10	some	some	DT
cord-306414-2dv3qced	25	11	patients	patient	NNS
cord-306414-2dv3qced	25	12	develop	develop	VBP
cord-306414-2dv3qced	25	13	severe	severe	JJ
cord-306414-2dv3qced	25	14	disease	disease	NN
cord-306414-2dv3qced	25	15	,	,	,
cord-306414-2dv3qced	25	16	while	while	IN
cord-306414-2dv3qced	25	17	others	other	NNS
cord-306414-2dv3qced	25	18	do	do	VBP
cord-306414-2dv3qced	25	19	not	not	RB
cord-306414-2dv3qced	25	20	;	;	:
cord-306414-2dv3qced	25	21	and	and	CC
cord-306414-2dv3qced	25	22	how	how	WRB
cord-306414-2dv3qced	25	23	genetic	genetic	JJ
cord-306414-2dv3qced	25	24	variabilities	variability	NNS
cord-306414-2dv3qced	25	25	within	within	IN
cord-306414-2dv3qced	25	26	the	the	DT
cord-306414-2dv3qced	25	27	immune	immune	JJ
cord-306414-2dv3qced	25	28	system	system	NN
cord-306414-2dv3qced	25	29	impact	impact	NN
cord-306414-2dv3qced	25	30	individual	individual	JJ
cord-306414-2dv3qced	25	31	antiviral	antiviral	JJ
cord-306414-2dv3qced	25	32	immune	immune	JJ
cord-306414-2dv3qced	25	33	response	response	NN
cord-306414-2dv3qced	25	34	.	.	.
cord-306414-2dv3qced	26	1	The	the	DT
cord-306414-2dv3qced	26	2	Role	role	NN
cord-306414-2dv3qced	26	3	of	of	IN
cord-306414-2dv3qced	26	4	T	T	NNP
cord-306414-2dv3qced	26	5	Cells	cell	NNS
cord-306414-2dv3qced	26	6	in	in	IN
cord-306414-2dv3qced	26	7	the	the	DT
cord-306414-2dv3qced	26	8	Immune	Immune	NNP
cord-306414-2dv3qced	26	9	Response	response	NN
cord-306414-2dv3qced	26	10	against	against	IN
cord-306414-2dv3qced	26	11	SARS	SARS	NNP
cord-306414-2dv3qced	26	12	-	-	HYPH
cord-306414-2dv3qced	26	13	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	26	14	Respiratory	respiratory	JJ
cord-306414-2dv3qced	26	15	viruses	virus	NNS
cord-306414-2dv3qced	26	16	have	have	VBP
cord-306414-2dv3qced	26	17	evolved	evolve	VBN
cord-306414-2dv3qced	26	18	in	in	IN
cord-306414-2dv3qced	26	19	many	many	JJ
cord-306414-2dv3qced	26	20	ways	way	NNS
cord-306414-2dv3qced	26	21	to	to	TO
cord-306414-2dv3qced	26	22	evade	evade	VB
cord-306414-2dv3qced	26	23	or	or	CC
cord-306414-2dv3qced	26	24	neutralize	neutralize	VB
cord-306414-2dv3qced	26	25	innate	innate	JJ
cord-306414-2dv3qced	26	26	immunity	immunity	NN
cord-306414-2dv3qced	26	27	;	;	:
cord-306414-2dv3qced	26	28	therefore	therefore	RB
cord-306414-2dv3qced	26	29	,	,	,
cord-306414-2dv3qced	26	30	adaptive	adaptive	JJ
cord-306414-2dv3qced	26	31	immunity	immunity	NN
cord-306414-2dv3qced	26	32	,	,	,
cord-306414-2dv3qced	26	33	which	which	WDT
cord-306414-2dv3qced	26	34	is	be	VBZ
cord-306414-2dv3qced	26	35	comprised	comprise	VBN
cord-306414-2dv3qced	26	36	of	of	IN
cord-306414-2dv3qced	26	37	B	b	NN
cord-306414-2dv3qced	26	38	and	and	CC
cord-306414-2dv3qced	26	39	T	T	NNP
cord-306414-2dv3qced	26	40	cells	cell	NNS
cord-306414-2dv3qced	26	41	,	,	,
cord-306414-2dv3qced	26	42	must	must	MD
cord-306414-2dv3qced	26	43	also	also	RB
cord-306414-2dv3qced	26	44	become	become	VB
cord-306414-2dv3qced	26	45	activated	activate	VBN
cord-306414-2dv3qced	26	46	for	for	IN
cord-306414-2dv3qced	26	47	proper	proper	JJ
cord-306414-2dv3qced	26	48	response	response	NN
cord-306414-2dv3qced	26	49	.	.	.
cord-306414-2dv3qced	27	1	B	b	NN
cord-306414-2dv3qced	27	2	cells	cell	NNS
cord-306414-2dv3qced	27	3	are	be	VBP
cord-306414-2dv3qced	27	4	derived	derive	VBN
cord-306414-2dv3qced	27	5	from	from	IN
cord-306414-2dv3qced	27	6	the	the	DT
cord-306414-2dv3qced	27	7	bone	bone	NN
cord-306414-2dv3qced	27	8	marrow	marrow	NN
cord-306414-2dv3qced	27	9	and	and	CC
cord-306414-2dv3qced	27	10	produce	produce	VB
cord-306414-2dv3qced	27	11	antibodies	antibody	NNS
cord-306414-2dv3qced	27	12	that	that	WDT
cord-306414-2dv3qced	27	13	bind	bind	VBP
cord-306414-2dv3qced	27	14	to	to	IN
cord-306414-2dv3qced	27	15	virus	virus	NN
cord-306414-2dv3qced	27	16	particles	particle	NNS
cord-306414-2dv3qced	27	17	in	in	IN
cord-306414-2dv3qced	27	18	the	the	DT
cord-306414-2dv3qced	27	19	blood	blood	NN
cord-306414-2dv3qced	27	20	and	and	CC
cord-306414-2dv3qced	27	21	mucosal	mucosal	JJ
cord-306414-2dv3qced	27	22	surfaces	surface	NNS
cord-306414-2dv3qced	27	23	,	,	,
cord-306414-2dv3qced	27	24	preventing	prevent	VBG
cord-306414-2dv3qced	27	25	the	the	DT
cord-306414-2dv3qced	27	26	spread	spread	NN
cord-306414-2dv3qced	27	27	of	of	IN
cord-306414-2dv3qced	27	28	the	the	DT
cord-306414-2dv3qced	27	29	infection	infection	NN
cord-306414-2dv3qced	27	30	(	(	-LRB-
cord-306414-2dv3qced	27	31	humoral	humoral	JJ
cord-306414-2dv3qced	27	32	mediated	mediate	VBN
cord-306414-2dv3qced	27	33	antiviral	antiviral	JJ
cord-306414-2dv3qced	27	34	response	response	NN
cord-306414-2dv3qced	27	35	)	)	-RRB-
cord-306414-2dv3qced	27	36	.	.	.
cord-306414-2dv3qced	28	1	Thus	thus	RB
cord-306414-2dv3qced	28	2	,	,	,
cord-306414-2dv3qced	28	3	there	there	EX
cord-306414-2dv3qced	28	4	is	be	VBZ
cord-306414-2dv3qced	28	5	an	an	DT
cord-306414-2dv3qced	28	6	immense	immense	JJ
cord-306414-2dv3qced	28	7	research	research	NN
cord-306414-2dv3qced	28	8	interest	interest	NN
cord-306414-2dv3qced	28	9	in	in	IN
cord-306414-2dv3qced	28	10	the	the	DT
cord-306414-2dv3qced	28	11	identification	identification	NN
cord-306414-2dv3qced	28	12	and	and	CC
cord-306414-2dv3qced	28	13	the	the	DT
cord-306414-2dv3qced	28	14	use	use	NN
cord-306414-2dv3qced	28	15	of	of	IN
cord-306414-2dv3qced	28	16	the	the	DT
cord-306414-2dv3qced	28	17	antibodies	antibody	NNS
cord-306414-2dv3qced	28	18	developed	develop	VBN
cord-306414-2dv3qced	28	19	against	against	IN
cord-306414-2dv3qced	28	20	the	the	DT
cord-306414-2dv3qced	28	21	SARS	SARS	NNP
cord-306414-2dv3qced	28	22	-	-	HYPH
cord-306414-2dv3qced	28	23	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	28	24	as	as	IN
cord-306414-2dv3qced	28	25	a	a	DT
cord-306414-2dv3qced	28	26	biomarker	biomarker	NN
cord-306414-2dv3qced	28	27	for	for	IN
cord-306414-2dv3qced	28	28	the	the	DT
cord-306414-2dv3qced	28	29	development	development	NN
cord-306414-2dv3qced	28	30	of	of	IN
cord-306414-2dv3qced	28	31	individual	individual	JJ
cord-306414-2dv3qced	28	32	immunity	immunity	NN
cord-306414-2dv3qced	28	33	or	or	CC
cord-306414-2dv3qced	28	34	for	for	IN
cord-306414-2dv3qced	28	35	therapeutic	therapeutic	JJ
cord-306414-2dv3qced	28	36	purposes	purpose	NNS
cord-306414-2dv3qced	28	37	as	as	IN
cord-306414-2dv3qced	28	38	in	in	IN
cord-306414-2dv3qced	28	39	the	the	DT
cord-306414-2dv3qced	28	40	convalescent	convalescent	JJ
cord-306414-2dv3qced	28	41	plasma	plasma	NN
cord-306414-2dv3qced	28	42	therapy	therapy	NN
cord-306414-2dv3qced	28	43	[	[	-LRB-
cord-306414-2dv3qced	28	44	12	12	CD
cord-306414-2dv3qced	28	45	,	,	,
cord-306414-2dv3qced	28	46	13	13	CD
cord-306414-2dv3qced	28	47	]	]	-RRB-
cord-306414-2dv3qced	28	48	.	.	.
cord-306414-2dv3qced	29	1	There	there	EX
cord-306414-2dv3qced	29	2	are	be	VBP
cord-306414-2dv3qced	29	3	also	also	RB
cord-306414-2dv3qced	29	4	substantial	substantial	JJ
cord-306414-2dv3qced	29	5	ongoing	ongoing	JJ
cord-306414-2dv3qced	29	6	efforts	effort	NNS
cord-306414-2dv3qced	29	7	placed	place	VBN
cord-306414-2dv3qced	29	8	to	to	TO
cord-306414-2dv3qced	29	9	develop	develop	VB
cord-306414-2dv3qced	29	10	serological	serological	JJ
cord-306414-2dv3qced	29	11	tests	test	NNS
cord-306414-2dv3qced	29	12	to	to	TO
cord-306414-2dv3qced	29	13	accurately	accurately	RB
cord-306414-2dv3qced	29	14	measure	measure	VB
cord-306414-2dv3qced	29	15	the	the	DT
cord-306414-2dv3qced	29	16	levels	level	NNS
cord-306414-2dv3qced	29	17	of	of	IN
cord-306414-2dv3qced	29	18	antiviral	antiviral	JJ
cord-306414-2dv3qced	29	19	antibodies	antibody	NNS
cord-306414-2dv3qced	29	20	in	in	IN
cord-306414-2dv3qced	29	21	an	an	DT
cord-306414-2dv3qced	29	22	individual	individual	NN
cord-306414-2dv3qced	29	23	[	[	-LRB-
cord-306414-2dv3qced	29	24	14	14	CD
cord-306414-2dv3qced	29	25	]	]	-RRB-
cord-306414-2dv3qced	29	26	.	.	.
cord-306414-2dv3qced	30	1	This	this	DT
cord-306414-2dv3qced	30	2	should	should	MD
cord-306414-2dv3qced	30	3	help	help	VB
cord-306414-2dv3qced	30	4	the	the	DT
cord-306414-2dv3qced	30	5	epidemiological	epidemiological	JJ
cord-306414-2dv3qced	30	6	assessment	assessment	NN
cord-306414-2dv3qced	30	7	of	of	IN
cord-306414-2dv3qced	30	8	the	the	DT
cord-306414-2dv3qced	30	9	scale	scale	NN
cord-306414-2dv3qced	30	10	of	of	IN
cord-306414-2dv3qced	30	11	the	the	DT
cord-306414-2dv3qced	30	12	viral	viral	JJ
cord-306414-2dv3qced	30	13	spread	spread	NN
cord-306414-2dv3qced	30	14	and	and	CC
cord-306414-2dv3qced	30	15	allow	allow	VB
cord-306414-2dv3qced	30	16	countries	country	NNS
cord-306414-2dv3qced	30	17	to	to	TO
cord-306414-2dv3qced	30	18	plan	plan	VB
cord-306414-2dv3qced	30	19	for	for	IN
cord-306414-2dv3qced	30	20	ending	end	VBG
cord-306414-2dv3qced	30	21	lockdowns	lockdown	NNS
cord-306414-2dv3qced	30	22	and	and	CC
cord-306414-2dv3qced	30	23	the	the	DT
cord-306414-2dv3qced	30	24	return	return	NN
cord-306414-2dv3qced	30	25	to	to	IN
cord-306414-2dv3qced	30	26	normal	normal	JJ
cord-306414-2dv3qced	30	27	life	life	NN
cord-306414-2dv3qced	30	28	.	.	.
cord-306414-2dv3qced	31	1	However	however	RB
cord-306414-2dv3qced	31	2	,	,	,
cord-306414-2dv3qced	31	3	current	current	JJ
cord-306414-2dv3qced	31	4	challenges	challenge	NNS
cord-306414-2dv3qced	31	5	with	with	IN
cord-306414-2dv3qced	31	6	the	the	DT
cord-306414-2dv3qced	31	7	sensitivity	sensitivity	NN
cord-306414-2dv3qced	31	8	and	and	CC
cord-306414-2dv3qced	31	9	specificity	specificity	NN
cord-306414-2dv3qced	31	10	for	for	IN
cord-306414-2dv3qced	31	11	some	some	DT
cord-306414-2dv3qced	31	12	of	of	IN
cord-306414-2dv3qced	31	13	these	these	DT
cord-306414-2dv3qced	31	14	assays	assay	NNS
cord-306414-2dv3qced	31	15	are	be	VBP
cord-306414-2dv3qced	31	16	still	still	RB
cord-306414-2dv3qced	31	17	limiting	limit	VBG
cord-306414-2dv3qced	31	18	their	-PRON-	PRP$
cord-306414-2dv3qced	31	19	wide	wide	JJ
cord-306414-2dv3qced	31	20	use	use	NN
cord-306414-2dv3qced	31	21	.	.	.
cord-306414-2dv3qced	32	1	T	t	NN
cord-306414-2dv3qced	32	2	cells	cell	NNS
cord-306414-2dv3qced	32	3	,	,	,
cord-306414-2dv3qced	32	4	however	however	RB
cord-306414-2dv3qced	32	5	,	,	,
cord-306414-2dv3qced	32	6	mature	mature	VB
cord-306414-2dv3qced	32	7	in	in	IN
cord-306414-2dv3qced	32	8	the	the	DT
cord-306414-2dv3qced	32	9	thymus	thymus	NN
cord-306414-2dv3qced	32	10	,	,	,
cord-306414-2dv3qced	32	11	and	and	CC
cord-306414-2dv3qced	32	12	CD8	CD8	NNP
cord-306414-2dv3qced	32	13	+	+	CC
cord-306414-2dv3qced	32	14	T	T	NNP
cord-306414-2dv3qced	32	15	cells	cell	NNS
cord-306414-2dv3qced	32	16	kill	kill	VBP
cord-306414-2dv3qced	32	17	virus	virus	NN
cord-306414-2dv3qced	32	18	-	-	HYPH
cord-306414-2dv3qced	32	19	infected	infect	VBN
cord-306414-2dv3qced	32	20	cells	cell	NNS
cord-306414-2dv3qced	32	21	(	(	-LRB-
cord-306414-2dv3qced	32	22	cell	cell	NN
cord-306414-2dv3qced	32	23	-	-	HYPH
cord-306414-2dv3qced	32	24	mediated	mediate	VBN
cord-306414-2dv3qced	32	25	antiviral	antiviral	JJ
cord-306414-2dv3qced	32	26	response	response	NN
cord-306414-2dv3qced	32	27	)	)	-RRB-
cord-306414-2dv3qced	32	28	through	through	IN
cord-306414-2dv3qced	32	29	T	T	NNP
cord-306414-2dv3qced	32	30	cell	cell	NN
cord-306414-2dv3qced	32	31	receptor	receptor	NN
cord-306414-2dv3qced	32	32	(	(	-LRB-
cord-306414-2dv3qced	32	33	TCR)-mediated	tcr)-mediate	VBN
cord-306414-2dv3qced	32	34	recognition	recognition	NN
cord-306414-2dv3qced	32	35	of	of	IN
cord-306414-2dv3qced	32	36	viral	viral	JJ
cord-306414-2dv3qced	32	37	antigens	antigen	NNS
cord-306414-2dv3qced	32	38	.	.	.
cord-306414-2dv3qced	33	1	Similar	similar	JJ
cord-306414-2dv3qced	33	2	to	to	IN
cord-306414-2dv3qced	33	3	the	the	DT
cord-306414-2dv3qced	33	4	humoral	humoral	JJ
cord-306414-2dv3qced	33	5	mediated	mediate	VBN
cord-306414-2dv3qced	33	6	response	response	NN
cord-306414-2dv3qced	33	7	,	,	,
cord-306414-2dv3qced	33	8	T	t	NN
cord-306414-2dv3qced	33	9	cells	cell	NNS
cord-306414-2dv3qced	33	10	are	be	VBP
cord-306414-2dv3qced	33	11	also	also	RB
cord-306414-2dv3qced	33	12	essential	essential	JJ
cord-306414-2dv3qced	33	13	for	for	IN
cord-306414-2dv3qced	33	14	antiviral	antiviral	JJ
cord-306414-2dv3qced	33	15	defense	defense	NN
cord-306414-2dv3qced	33	16	.	.	.
cord-306414-2dv3qced	34	1	Here	here	RB
cord-306414-2dv3qced	34	2	,	,	,
cord-306414-2dv3qced	34	3	we	-PRON-	PRP
cord-306414-2dv3qced	34	4	focus	focus	VBP
cord-306414-2dv3qced	34	5	on	on	IN
cord-306414-2dv3qced	34	6	the	the	DT
cord-306414-2dv3qced	34	7	role	role	NN
cord-306414-2dv3qced	34	8	of	of	IN
cord-306414-2dv3qced	34	9	T	T	NNP
cord-306414-2dv3qced	34	10	cell	cell	NN
cord-306414-2dv3qced	34	11	(	(	-LRB-
cord-306414-2dv3qced	34	12	cell	cell	NN
cord-306414-2dv3qced	34	13	-	-	HYPH
cord-306414-2dv3qced	34	14	mediated	mediate	VBN
cord-306414-2dv3qced	34	15	)	)	-RRB-
cord-306414-2dv3qced	34	16	responses	response	NNS
cord-306414-2dv3qced	34	17	and	and	CC
cord-306414-2dv3qced	34	18	the	the	DT
cord-306414-2dv3qced	34	19	TCR	TCR	NNP
cord-306414-2dv3qced	34	20	repertoire	repertoire	NN
cord-306414-2dv3qced	34	21	,	,	,
cord-306414-2dv3qced	34	22	as	as	IN
cord-306414-2dv3qced	34	23	they	-PRON-	PRP
cord-306414-2dv3qced	34	24	are	be	VBP
cord-306414-2dv3qced	34	25	often	often	RB
cord-306414-2dv3qced	34	26	overlooked	overlook	VBN
cord-306414-2dv3qced	34	27	in	in	IN
cord-306414-2dv3qced	34	28	early	early	JJ
cord-306414-2dv3qced	34	29	viral	viral	JJ
cord-306414-2dv3qced	34	30	studies	study	NNS
cord-306414-2dv3qced	34	31	.	.	.
cord-306414-2dv3qced	35	1	T	t	NN
cord-306414-2dv3qced	35	2	cells	cell	NNS
cord-306414-2dv3qced	35	3	play	play	VBP
cord-306414-2dv3qced	35	4	a	a	DT
cord-306414-2dv3qced	35	5	crucial	crucial	JJ
cord-306414-2dv3qced	35	6	role	role	NN
cord-306414-2dv3qced	35	7	in	in	IN
cord-306414-2dv3qced	35	8	the	the	DT
cord-306414-2dv3qced	35	9	immune	immune	JJ
cord-306414-2dv3qced	35	10	response	response	NN
cord-306414-2dv3qced	35	11	to	to	IN
cord-306414-2dv3qced	35	12	viral	viral	JJ
cord-306414-2dv3qced	35	13	infections	infection	NNS
cord-306414-2dv3qced	35	14	due	due	JJ
cord-306414-2dv3qced	35	15	to	to	IN
cord-306414-2dv3qced	35	16	their	-PRON-	PRP$
cord-306414-2dv3qced	35	17	ability	ability	NN
cord-306414-2dv3qced	35	18	to	to	TO
cord-306414-2dv3qced	35	19	selectively	selectively	RB
cord-306414-2dv3qced	35	20	eliminate	eliminate	VB
cord-306414-2dv3qced	35	21	virus	virus	NN
cord-306414-2dv3qced	35	22	-	-	HYPH
cord-306414-2dv3qced	35	23	infected	infect	VBN
cord-306414-2dv3qced	35	24	cells	cell	NNS
cord-306414-2dv3qced	35	25	[	[	-LRB-
cord-306414-2dv3qced	35	26	15	15	CD
cord-306414-2dv3qced	35	27	]	]	-RRB-
cord-306414-2dv3qced	35	28	.	.	.
cord-306414-2dv3qced	36	1	CD8	CD8	NNP
cord-306414-2dv3qced	36	2	+	+	CC
cord-306414-2dv3qced	36	3	T	T	NNP
cord-306414-2dv3qced	36	4	cells	cell	NNS
cord-306414-2dv3qced	36	5	recognize	recognize	VBP
cord-306414-2dv3qced	36	6	viral	viral	JJ
cord-306414-2dv3qced	36	7	antigens	antigen	NNS
cord-306414-2dv3qced	36	8	through	through	IN
cord-306414-2dv3qced	36	9	their	-PRON-	PRP$
cord-306414-2dv3qced	36	10	presentation	presentation	NN
cord-306414-2dv3qced	36	11	by	by	IN
cord-306414-2dv3qced	36	12	major	major	JJ
cord-306414-2dv3qced	36	13	histocompatibility	histocompatibility	NN
cord-306414-2dv3qced	36	14	class	class	NN
cord-306414-2dv3qced	37	1	I	-PRON-	PRP
cord-306414-2dv3qced	38	1	(	(	-LRB-
cord-306414-2dv3qced	38	2	MHC	MHC	NNP
cord-306414-2dv3qced	39	1	I	-PRON-	PRP
cord-306414-2dv3qced	39	2	)	)	-RRB-
cord-306414-2dv3qced	39	3	molecules	molecule	NNS
cord-306414-2dv3qced	39	4	on	on	IN
cord-306414-2dv3qced	39	5	virally	virally	RB
cord-306414-2dv3qced	39	6	infected	infect	VBN
cord-306414-2dv3qced	39	7	cells	cell	NNS
cord-306414-2dv3qced	39	8	as	as	RB
cord-306414-2dv3qced	39	9	well	well	RB
cord-306414-2dv3qced	39	10	as	as	IN
cord-306414-2dv3qced	39	11	on	on	IN
cord-306414-2dv3qced	39	12	uninfected	uninfected	JJ
cord-306414-2dv3qced	39	13	dendritic	dendritic	JJ
cord-306414-2dv3qced	39	14	cells	cell	NNS
cord-306414-2dv3qced	39	15	and	and	CC
cord-306414-2dv3qced	39	16	macrophages	macrophage	NNS
cord-306414-2dv3qced	39	17	in	in	IN
cord-306414-2dv3qced	39	18	the	the	DT
cord-306414-2dv3qced	39	19	lymph	lymph	NN
cord-306414-2dv3qced	39	20	nodes	node	NNS
cord-306414-2dv3qced	39	21	(	(	-LRB-
cord-306414-2dv3qced	39	22	a	a	DT
cord-306414-2dv3qced	39	23	process	process	NN
cord-306414-2dv3qced	39	24	known	know	VBN
cord-306414-2dv3qced	39	25	as	as	IN
cord-306414-2dv3qced	39	26	cross	cross	NN
cord-306414-2dv3qced	39	27	-	-	NN
cord-306414-2dv3qced	39	28	presentation	presentation	NN
cord-306414-2dv3qced	39	29	)	)	-RRB-
cord-306414-2dv3qced	40	1	(	(	-LRB-
cord-306414-2dv3qced	40	2	Figure	figure	NN
cord-306414-2dv3qced	40	3	1	1	CD
cord-306414-2dv3qced	40	4	)	)	-RRB-
cord-306414-2dv3qced	40	5	[	[	-LRB-
cord-306414-2dv3qced	40	6	16	16	CD
cord-306414-2dv3qced	40	7	]	]	-RRB-
cord-306414-2dv3qced	40	8	.	.	.
cord-306414-2dv3qced	41	1	Once	once	IN
cord-306414-2dv3qced	41	2	T	t	NN
cord-306414-2dv3qced	41	3	cells	cell	NNS
cord-306414-2dv3qced	41	4	become	become	VBP
cord-306414-2dv3qced	41	5	activated	activate	VBN
cord-306414-2dv3qced	41	6	through	through	IN
cord-306414-2dv3qced	41	7	antigen	antigen	NN
cord-306414-2dv3qced	41	8	recognition	recognition	NN
cord-306414-2dv3qced	41	9	,	,	,
cord-306414-2dv3qced	41	10	they	-PRON-	PRP
cord-306414-2dv3qced	41	11	undergo	undergo	VBP
cord-306414-2dv3qced	41	12	a	a	DT
cord-306414-2dv3qced	41	13	process	process	NN
cord-306414-2dv3qced	41	14	termed	term	VBN
cord-306414-2dv3qced	41	15	'	'	``
cord-306414-2dv3qced	41	16	clonal	clonal	JJ
cord-306414-2dv3qced	41	17	expansion	expansion	NN
cord-306414-2dv3qced	41	18	'	'	''
cord-306414-2dv3qced	41	19	,	,	,
cord-306414-2dv3qced	41	20	in	in	IN
cord-306414-2dv3qced	41	21	which	which	WDT
cord-306414-2dv3qced	41	22	the	the	DT
cord-306414-2dv3qced	41	23	activated	activate	VBN
cord-306414-2dv3qced	41	24	T	T	NNP
cord-306414-2dv3qced	41	25	cell	cell	NN
cord-306414-2dv3qced	41	26	rapidly	rapidly	RB
cord-306414-2dv3qced	41	27	proliferates	proliferate	VBZ
cord-306414-2dv3qced	41	28	to	to	TO
cord-306414-2dv3qced	41	29	generate	generate	VB
cord-306414-2dv3qced	41	30	a	a	DT
cord-306414-2dv3qced	41	31	large	large	JJ
cord-306414-2dv3qced	41	32	number	number	NN
cord-306414-2dv3qced	41	33	of	of	IN
cord-306414-2dv3qced	41	34	T	t	NN
cord-306414-2dv3qced	41	35	cells	cell	NNS
cord-306414-2dv3qced	41	36	with	with	IN
cord-306414-2dv3qced	41	37	identical	identical	JJ
cord-306414-2dv3qced	41	38	TCRs	tcr	NNS
cord-306414-2dv3qced	41	39	and	and	CC
cord-306414-2dv3qced	41	40	thus	thus	RB
cord-306414-2dv3qced	41	41	,	,	,
cord-306414-2dv3qced	41	42	identical	identical	JJ
cord-306414-2dv3qced	41	43	antigen	antigen	NN
cord-306414-2dv3qced	41	44	recognition	recognition	NN
cord-306414-2dv3qced	41	45	[	[	-LRB-
cord-306414-2dv3qced	41	46	17	17	CD
cord-306414-2dv3qced	41	47	]	]	-RRB-
cord-306414-2dv3qced	41	48	.	.	.
cord-306414-2dv3qced	42	1	To	to	TO
cord-306414-2dv3qced	42	2	eliminate	eliminate	VB
cord-306414-2dv3qced	42	3	virus	virus	NN
cord-306414-2dv3qced	42	4	-	-	HYPH
cord-306414-2dv3qced	42	5	infected	infect	VBN
cord-306414-2dv3qced	42	6	cells	cell	NNS
cord-306414-2dv3qced	42	7	,	,	,
cord-306414-2dv3qced	42	8	expanded	expand	VBD
cord-306414-2dv3qced	42	9	CD8	CD8	NNP
cord-306414-2dv3qced	42	10	+	+	CC
cord-306414-2dv3qced	42	11	T	T	NNP
cord-306414-2dv3qced	42	12	cell	cell	NN
cord-306414-2dv3qced	42	13	clones	clone	NNS
cord-306414-2dv3qced	42	14	,	,	,
cord-306414-2dv3qced	42	15	with	with	IN
cord-306414-2dv3qced	42	16	TCRs	tcr	NNS
cord-306414-2dv3qced	42	17	specific	specific	JJ
cord-306414-2dv3qced	42	18	for	for	IN
cord-306414-2dv3qced	42	19	viral	viral	JJ
cord-306414-2dv3qced	42	20	antigens	antigen	NNS
cord-306414-2dv3qced	42	21	,	,	,
cord-306414-2dv3qced	42	22	directly	directly	RB
cord-306414-2dv3qced	42	23	lyse	lyse	VB
cord-306414-2dv3qced	42	24	them	-PRON-	PRP
cord-306414-2dv3qced	42	25	by	by	IN
cord-306414-2dv3qced	42	26	perforin	perforin	NNP
cord-306414-2dv3qced	42	27	/	/	SYM
cord-306414-2dv3qced	42	28	granzyme	granzyme	NNP
cord-306414-2dv3qced	42	29	release	release	NN
cord-306414-2dv3qced	42	30	,	,	,
cord-306414-2dv3qced	42	31	induce	induce	VB
cord-306414-2dv3qced	42	32	apoptosis	apoptosis	NN
cord-306414-2dv3qced	42	33	through	through	IN
cord-306414-2dv3qced	42	34	tumor	tumor	NN
cord-306414-2dv3qced	42	35	necrosis	necrosis	NN
cord-306414-2dv3qced	42	36	factor	factor	NN
cord-306414-2dv3qced	42	37	-	-	HYPH
cord-306414-2dv3qced	42	38	related	relate	VBN
cord-306414-2dv3qced	42	39	apoptosis	apoptosis	NN
cord-306414-2dv3qced	42	40	-	-	HYPH
cord-306414-2dv3qced	42	41	inducing	induce	VBG
cord-306414-2dv3qced	42	42	ligand	ligand	NN
cord-306414-2dv3qced	42	43	(	(	-LRB-
cord-306414-2dv3qced	42	44	TRAIL	TRAIL	NNP
cord-306414-2dv3qced	42	45	)	)	-RRB-
cord-306414-2dv3qced	42	46	or	or	CC
cord-306414-2dv3qced	42	47	Fas	Fas	NNP
cord-306414-2dv3qced	42	48	ligand	ligand	NN
cord-306414-2dv3qced	42	49	,	,	,
cord-306414-2dv3qced	42	50	and	and	CC
cord-306414-2dv3qced	42	51	secrete	secrete	JJ
cord-306414-2dv3qced	42	52	proinflammatory	proinflammatory	JJ
cord-306414-2dv3qced	42	53	mediators	mediator	NNS
cord-306414-2dv3qced	42	54	such	such	JJ
cord-306414-2dv3qced	42	55	as	as	IN
cord-306414-2dv3qced	42	56	interferon	interferon	NN
cord-306414-2dv3qced	42	57	-	-	HYPH
cord-306414-2dv3qced	42	58	γ	γ	NN
cord-306414-2dv3qced	42	59	(	(	-LRB-
cord-306414-2dv3qced	42	60	IFN	IFN	NNP
cord-306414-2dv3qced	42	61	-	-	HYPH
cord-306414-2dv3qced	42	62	γ	γ	NNP
cord-306414-2dv3qced	42	63	)	)	-RRB-
cord-306414-2dv3qced	42	64	[	[	-LRB-
cord-306414-2dv3qced	42	65	18	18	CD
cord-306414-2dv3qced	42	66	]	]	-RRB-
cord-306414-2dv3qced	42	67	(	(	-LRB-
cord-306414-2dv3qced	42	68	Figure	figure	NN
cord-306414-2dv3qced	42	69	1	1	CD
cord-306414-2dv3qced	42	70	)	)	-RRB-
cord-306414-2dv3qced	42	71	.	.	.
cord-306414-2dv3qced	43	1	T	t	NN
cord-306414-2dv3qced	43	2	cells	cell	NNS
cord-306414-2dv3qced	43	3	are	be	VBP
cord-306414-2dv3qced	43	4	crucial	crucial	JJ
cord-306414-2dv3qced	43	5	mediators	mediator	NNS
cord-306414-2dv3qced	43	6	of	of	IN
cord-306414-2dv3qced	43	7	antiviral	antiviral	JJ
cord-306414-2dv3qced	43	8	adaptive	adaptive	JJ
cord-306414-2dv3qced	43	9	immunity	immunity	NN
cord-306414-2dv3qced	43	10	and	and	CC
cord-306414-2dv3qced	43	11	delineating	delineate	VBG
cord-306414-2dv3qced	43	12	the	the	DT
cord-306414-2dv3qced	43	13	role	role	NN
cord-306414-2dv3qced	43	14	of	of	IN
cord-306414-2dv3qced	43	15	the	the	DT
cord-306414-2dv3qced	43	16	TCR	TCR	NNP
cord-306414-2dv3qced	43	17	in	in	IN
cord-306414-2dv3qced	43	18	the	the	DT
cord-306414-2dv3qced	43	19	context	context	NN
cord-306414-2dv3qced	43	20	of	of	IN
cord-306414-2dv3qced	43	21	SARS	SARS	NNP
cord-306414-2dv3qced	43	22	-	-	HYPH
cord-306414-2dv3qced	43	23	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	43	24	should	should	MD
cord-306414-2dv3qced	43	25	garner	garner	VB
cord-306414-2dv3qced	43	26	vast	vast	JJ
cord-306414-2dv3qced	43	27	interest	interest	NN
cord-306414-2dv3qced	43	28	.	.	.
cord-306414-2dv3qced	44	1	The	the	DT
cord-306414-2dv3qced	44	2	Evolution	evolution	NN
cord-306414-2dv3qced	44	3	of	of	IN
cord-306414-2dv3qced	44	4	the	the	DT
cord-306414-2dv3qced	44	5	TCR	TCR	NNP
cord-306414-2dv3qced	44	6	Repertoire	repertoire	NN
cord-306414-2dv3qced	44	7	during	during	IN
cord-306414-2dv3qced	44	8	Viral	viral	JJ
cord-306414-2dv3qced	44	9	Infection	infection	NN
cord-306414-2dv3qced	45	1	The	the	DT
cord-306414-2dv3qced	45	2	specificity	specificity	NN
cord-306414-2dv3qced	45	3	of	of	IN
cord-306414-2dv3qced	45	4	T	t	NN
cord-306414-2dv3qced	45	5	cells	cell	NNS
cord-306414-2dv3qced	45	6	toward	toward	IN
cord-306414-2dv3qced	45	7	viral	viral	JJ
cord-306414-2dv3qced	45	8	antigens	antigen	NNS
cord-306414-2dv3qced	45	9	presented	present	VBN
cord-306414-2dv3qced	45	10	by	by	IN
cord-306414-2dv3qced	45	11	all	all	DT
cord-306414-2dv3qced	45	12	nucleated	nucleated	JJ
cord-306414-2dv3qced	45	13	cells	cell	NNS
cord-306414-2dv3qced	45	14	on	on	IN
cord-306414-2dv3qced	45	15	MHCs	mhc	NNS
cord-306414-2dv3qced	45	16	is	be	VBZ
cord-306414-2dv3qced	45	17	determined	determine	VBN
cord-306414-2dv3qced	45	18	by	by	IN
cord-306414-2dv3qced	45	19	their	-PRON-	PRP$
cord-306414-2dv3qced	45	20	TCR	TCR	NNP
cord-306414-2dv3qced	45	21	[	[	-LRB-
cord-306414-2dv3qced	45	22	19	19	CD
cord-306414-2dv3qced	45	23	]	]	-RRB-
cord-306414-2dv3qced	45	24	[	[	-LRB-
cord-306414-2dv3qced	45	25	20	20	CD
cord-306414-2dv3qced	45	26	]	]	-RRB-
cord-306414-2dv3qced	45	27	[	[	-LRB-
cord-306414-2dv3qced	45	28	21	21	CD
cord-306414-2dv3qced	45	29	]	]	-RRB-
cord-306414-2dv3qced	45	30	.	.	.
cord-306414-2dv3qced	46	1	Roughly	roughly	RB
cord-306414-2dv3qced	46	2	95	95	CD
cord-306414-2dv3qced	46	3	%	%	NN
cord-306414-2dv3qced	46	4	of	of	IN
cord-306414-2dv3qced	46	5	the	the	DT
cord-306414-2dv3qced	46	6	TCRs	tcr	NNS
cord-306414-2dv3qced	46	7	on	on	IN
cord-306414-2dv3qced	46	8	circulating	circulate	VBG
cord-306414-2dv3qced	46	9	T	T	NNP
cord-306414-2dv3qced	46	10	cells	cell	NNS
cord-306414-2dv3qced	46	11	are	be	VBP
cord-306414-2dv3qced	46	12	alpha	alpha	NN
cord-306414-2dv3qced	46	13	(	(	-LRB-
cord-306414-2dv3qced	46	14	α	α	NN
cord-306414-2dv3qced	46	15	)	)	-RRB-
cord-306414-2dv3qced	46	16	and	and	CC
cord-306414-2dv3qced	46	17	beta	beta	NN
cord-306414-2dv3qced	46	18	(	(	-LRB-
cord-306414-2dv3qced	46	19	β	β	NN
cord-306414-2dv3qced	46	20	)	)	-RRB-
cord-306414-2dv3qced	46	21	subunit	subunit	NN
cord-306414-2dv3qced	46	22	heterodimers	heterodimer	NNS
cord-306414-2dv3qced	46	23	.	.	.
cord-306414-2dv3qced	47	1	TCR	TCR	NNP
cord-306414-2dv3qced	47	2	specificity	specificity	NN
cord-306414-2dv3qced	47	3	for	for	IN
cord-306414-2dv3qced	47	4	any	any	DT
cord-306414-2dv3qced	47	5	given	give	VBN
cord-306414-2dv3qced	47	6	antigen	antigen	NN
cord-306414-2dv3qced	47	7	is	be	VBZ
cord-306414-2dv3qced	47	8	shaped	shape	VBN
cord-306414-2dv3qced	47	9	through	through	IN
cord-306414-2dv3qced	47	10	V(D)J	V(D)J	NNP
cord-306414-2dv3qced	47	11	recombination	recombination	NN
cord-306414-2dv3qced	47	12	(	(	-LRB-
cord-306414-2dv3qced	47	13	rearrangement	rearrangement	NN
cord-306414-2dv3qced	47	14	)	)	-RRB-
cord-306414-2dv3qced	47	15	[	[	-LRB-
cord-306414-2dv3qced	47	16	22	22	CD
cord-306414-2dv3qced	47	17	]	]	-RRB-
cord-306414-2dv3qced	47	18	.	.	.
cord-306414-2dv3qced	48	1	During	during	IN
cord-306414-2dv3qced	48	2	recombination	recombination	NN
cord-306414-2dv3qced	48	3	,	,	,
cord-306414-2dv3qced	48	4	V	V	NNP
cord-306414-2dv3qced	48	5	and	and	CC
cord-306414-2dv3qced	48	6	J	J	NNP
cord-306414-2dv3qced	48	7	(	(	-LRB-
cord-306414-2dv3qced	48	8	TCR	TCR	NNP
cord-306414-2dv3qced	48	9	alpha	alpha	NN
cord-306414-2dv3qced	48	10	)	)	-RRB-
cord-306414-2dv3qced	48	11	or	or	CC
cord-306414-2dv3qced	48	12	V	v	NN
cord-306414-2dv3qced	48	13	,	,	,
cord-306414-2dv3qced	48	14	D	D	NNP
cord-306414-2dv3qced	48	15	,	,	,
cord-306414-2dv3qced	48	16	and	and	CC
cord-306414-2dv3qced	48	17	J	J	NNP
cord-306414-2dv3qced	48	18	(	(	-LRB-
cord-306414-2dv3qced	48	19	TCR	TCR	NNP
cord-306414-2dv3qced	48	20	beta	beta	NN
cord-306414-2dv3qced	48	21	)	)	-RRB-
cord-306414-2dv3qced	48	22	gene	gene	NN
cord-306414-2dv3qced	48	23	segments	segment	NNS
cord-306414-2dv3qced	48	24	are	be	VBP
cord-306414-2dv3qced	48	25	randomly	randomly	RB
cord-306414-2dv3qced	48	26	selected	select	VBN
cord-306414-2dv3qced	48	27	from	from	IN
cord-306414-2dv3qced	48	28	an	an	DT
cord-306414-2dv3qced	48	29	array	array	NN
cord-306414-2dv3qced	48	30	of	of	IN
cord-306414-2dv3qced	48	31	V	V	NNP
cord-306414-2dv3qced	48	32	and	and	CC
cord-306414-2dv3qced	48	33	J	J	NNP
cord-306414-2dv3qced	48	34	exons	exon	NNS
cord-306414-2dv3qced	48	35	[	[	-LRB-
cord-306414-2dv3qced	48	36	23	23	CD
cord-306414-2dv3qced	48	37	]	]	-RRB-
cord-306414-2dv3qced	48	38	.	.	.
cord-306414-2dv3qced	49	1	They	-PRON-	PRP
cord-306414-2dv3qced	49	2	undergo	undergo	VBP
cord-306414-2dv3qced	49	3	Glossary	Glossary	NNP
cord-306414-2dv3qced	49	4	Adaptive	adaptive	JJ
cord-306414-2dv3qced	49	5	immunity	immunity	NN
cord-306414-2dv3qced	49	6	:	:	:
cord-306414-2dv3qced	49	7	immunity	immunity	NN
cord-306414-2dv3qced	49	8	that	that	WDT
cord-306414-2dv3qced	49	9	occurs	occur	VBZ
cord-306414-2dv3qced	49	10	in	in	IN
cord-306414-2dv3qced	49	11	response	response	NN
cord-306414-2dv3qced	49	12	to	to	IN
cord-306414-2dv3qced	49	13	specific	specific	JJ
cord-306414-2dv3qced	49	14	antigens	antigen	NNS
cord-306414-2dv3qced	49	15	.	.	.
cord-306414-2dv3qced	50	1	Activation	activation	NN
cord-306414-2dv3qced	50	2	of	of	IN
cord-306414-2dv3qced	50	3	this	this	DT
cord-306414-2dv3qced	50	4	immunity	immunity	NN
cord-306414-2dv3qced	50	5	is	be	VBZ
cord-306414-2dv3qced	50	6	dependent	dependent	JJ
cord-306414-2dv3qced	50	7	on	on	IN
cord-306414-2dv3qced	50	8	the	the	DT
cord-306414-2dv3qced	50	9	presentation	presentation	NN
cord-306414-2dv3qced	50	10	of	of	IN
cord-306414-2dv3qced	50	11	antigens	antigen	NNS
cord-306414-2dv3qced	50	12	by	by	IN
cord-306414-2dv3qced	50	13	the	the	DT
cord-306414-2dv3qced	50	14	innate	innate	JJ
cord-306414-2dv3qced	50	15	immune	immune	JJ
cord-306414-2dv3qced	50	16	system	system	NN
cord-306414-2dv3qced	50	17	.	.	.
cord-306414-2dv3qced	51	1	It	-PRON-	PRP
cord-306414-2dv3qced	51	2	is	be	VBZ
cord-306414-2dv3qced	51	3	mediated	mediate	VBN
cord-306414-2dv3qced	51	4	by	by	IN
cord-306414-2dv3qced	51	5	immunoglobulins	immunoglobulin	NNS
cord-306414-2dv3qced	51	6	and	and	CC
cord-306414-2dv3qced	51	7	T	t	NN
cord-306414-2dv3qced	51	8	cells	cell	NNS
cord-306414-2dv3qced	51	9	.	.	.
cord-306414-2dv3qced	52	1	Angiotensin	angiotensin	NN
cord-306414-2dv3qced	52	2	-	-	HYPH
cord-306414-2dv3qced	52	3	converting	convert	VBG
cord-306414-2dv3qced	52	4	enzyme	enzyme	NN
cord-306414-2dv3qced	52	5	2	2	CD
cord-306414-2dv3qced	52	6	(	(	-LRB-
cord-306414-2dv3qced	52	7	ACE2	ACE2	NNP
cord-306414-2dv3qced	52	8	)	)	-RRB-
cord-306414-2dv3qced	52	9	:	:	:
cord-306414-2dv3qced	52	10	a	a	DT
cord-306414-2dv3qced	52	11	carboxypeptidase	carboxypeptidase	NN
cord-306414-2dv3qced	52	12	that	that	WDT
cord-306414-2dv3qced	52	13	is	be	VBZ
cord-306414-2dv3qced	52	14	mainly	mainly	RB
cord-306414-2dv3qced	52	15	expressed	express	VBN
cord-306414-2dv3qced	52	16	in	in	IN
cord-306414-2dv3qced	52	17	vascular	vascular	JJ
cord-306414-2dv3qced	52	18	endothelial	endothelial	JJ
cord-306414-2dv3qced	52	19	cells	cell	NNS
cord-306414-2dv3qced	52	20	and	and	CC
cord-306414-2dv3qced	52	21	the	the	DT
cord-306414-2dv3qced	52	22	renal	renal	JJ
cord-306414-2dv3qced	52	23	tubular	tubular	JJ
cord-306414-2dv3qced	52	24	epithelium	epithelium	NN
cord-306414-2dv3qced	52	25	.	.	.
cord-306414-2dv3qced	53	1	ACE2	ACE2	NNP
cord-306414-2dv3qced	53	2	binds	bind	VBZ
cord-306414-2dv3qced	53	3	to	to	IN
cord-306414-2dv3qced	53	4	SARS	SARS	NNP
cord-306414-2dv3qced	53	5	-	-	HYPH
cord-306414-2dv3qced	53	6	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	53	7	spike	spike	NN
cord-306414-2dv3qced	53	8	protein	protein	NN
cord-306414-2dv3qced	53	9	and	and	CC
cord-306414-2dv3qced	53	10	promotes	promote	VBZ
cord-306414-2dv3qced	53	11	internalization	internalization	NN
cord-306414-2dv3qced	53	12	of	of	IN
cord-306414-2dv3qced	53	13	the	the	DT
cord-306414-2dv3qced	53	14	virus	virus	NN
cord-306414-2dv3qced	53	15	into	into	IN
cord-306414-2dv3qced	53	16	the	the	DT
cord-306414-2dv3qced	53	17	cells	cell	NNS
cord-306414-2dv3qced	53	18	.	.	.
cord-306414-2dv3qced	54	1	Antigens	antigen	NNS
cord-306414-2dv3qced	54	2	:	:	:
cord-306414-2dv3qced	54	3	molecule	molecule	NN
cord-306414-2dv3qced	54	4	that	that	WDT
cord-306414-2dv3qced	54	5	is	be	VBZ
cord-306414-2dv3qced	54	6	capable	capable	JJ
cord-306414-2dv3qced	54	7	of	of	IN
cord-306414-2dv3qced	54	8	stimulating	stimulate	VBG
cord-306414-2dv3qced	54	9	an	an	DT
cord-306414-2dv3qced	54	10	immune	immune	JJ
cord-306414-2dv3qced	54	11	response	response	NN
cord-306414-2dv3qced	54	12	,	,	,
cord-306414-2dv3qced	54	13	specifically	specifically	RB
cord-306414-2dv3qced	54	14	activating	activate	VBG
cord-306414-2dv3qced	54	15	T	T	NNP
cord-306414-2dv3qced	54	16	cells	cell	NNS
cord-306414-2dv3qced	54	17	or	or	CC
cord-306414-2dv3qced	54	18	B	b	NN
cord-306414-2dv3qced	54	19	cells	cell	NNS
cord-306414-2dv3qced	54	20	.	.	.
cord-306414-2dv3qced	55	1	CD8	CD8	NNP
cord-306414-2dv3qced	55	2	+	+	CC
cord-306414-2dv3qced	55	3	T	T	NNP
cord-306414-2dv3qced	55	4	cells	cell	NNS
cord-306414-2dv3qced	55	5	:	:	:
cord-306414-2dv3qced	56	1	T	T	NNP
cord-306414-2dv3qced	56	2	cells	cell	NNS
cord-306414-2dv3qced	56	3	that	that	WDT
cord-306414-2dv3qced	56	4	express	express	VBP
cord-306414-2dv3qced	56	5	CD8	CD8	NNP
cord-306414-2dv3qced	56	6	on	on	IN
cord-306414-2dv3qced	56	7	their	-PRON-	PRP$
cord-306414-2dv3qced	56	8	cell	cell	NN
cord-306414-2dv3qced	56	9	surface	surface	NN
cord-306414-2dv3qced	56	10	are	be	VBP
cord-306414-2dv3qced	56	11	selected	select	VBN
cord-306414-2dv3qced	56	12	in	in	IN
cord-306414-2dv3qced	56	13	the	the	DT
cord-306414-2dv3qced	56	14	thymus	thymus	NN
cord-306414-2dv3qced	56	15	to	to	TO
cord-306414-2dv3qced	56	16	recognize	recognize	VB
cord-306414-2dv3qced	56	17	and	and	CC
cord-306414-2dv3qced	56	18	respond	respond	VB
cord-306414-2dv3qced	56	19	to	to	IN
cord-306414-2dv3qced	56	20	foreign	foreign	JJ
cord-306414-2dv3qced	56	21	peptides	peptide	NNS
cord-306414-2dv3qced	56	22	that	that	WDT
cord-306414-2dv3qced	56	23	are	be	VBP
cord-306414-2dv3qced	56	24	presented	present	VBN
cord-306414-2dv3qced	56	25	in	in	IN
cord-306414-2dv3qced	56	26	the	the	DT
cord-306414-2dv3qced	56	27	groove	groove	NN
cord-306414-2dv3qced	56	28	of	of	IN
cord-306414-2dv3qced	56	29	MHC	MHC	NNP
cord-306414-2dv3qced	56	30	class	class	NN
cord-306414-2dv3qced	56	31	I	-PRON-	PRP
cord-306414-2dv3qced	56	32	molecules	molecule	NNS
cord-306414-2dv3qced	56	33	.	.	.
cord-306414-2dv3qced	57	1	Also	also	RB
cord-306414-2dv3qced	57	2	known	know	VBN
cord-306414-2dv3qced	57	3	as	as	IN
cord-306414-2dv3qced	57	4	cytotoxic	cytotoxic	JJ
cord-306414-2dv3qced	57	5	T	t	NN
cord-306414-2dv3qced	57	6	cells	cell	NNS
cord-306414-2dv3qced	57	7	.	.	.
cord-306414-2dv3qced	58	1	Clonal	Clonal	NNP
cord-306414-2dv3qced	58	2	expansion	expansion	NN
cord-306414-2dv3qced	58	3	:	:	:
cord-306414-2dv3qced	58	4	the	the	DT
cord-306414-2dv3qced	58	5	process	process	NN
cord-306414-2dv3qced	58	6	in	in	IN
cord-306414-2dv3qced	58	7	which	which	WDT
cord-306414-2dv3qced	58	8	a	a	DT
cord-306414-2dv3qced	58	9	small	small	JJ
cord-306414-2dv3qced	58	10	number	number	NN
cord-306414-2dv3qced	58	11	of	of	IN
cord-306414-2dv3qced	58	12	precursor	precursor	NN
cord-306414-2dv3qced	58	13	cells	cell	NNS
cord-306414-2dv3qced	58	14	that	that	WDT
cord-306414-2dv3qced	58	15	recognize	recognize	VBP
cord-306414-2dv3qced	58	16	a	a	DT
cord-306414-2dv3qced	58	17	specific	specific	JJ
cord-306414-2dv3qced	58	18	antigen	antigen	NN
cord-306414-2dv3qced	58	19	proliferate	proliferate	VBP
cord-306414-2dv3qced	58	20	into	into	IN
cord-306414-2dv3qced	58	21	expanded	expand	VBN
cord-306414-2dv3qced	58	22	clones	clone	NNS
cord-306414-2dv3qced	58	23	,	,	,
cord-306414-2dv3qced	58	24	differentiate	differentiate	VBP
cord-306414-2dv3qced	58	25	,	,	,
cord-306414-2dv3qced	58	26	and	and	CC
cord-306414-2dv3qced	58	27	acquire	acquire	VB
cord-306414-2dv3qced	58	28	various	various	JJ
cord-306414-2dv3qced	58	29	effector	effector	NN
cord-306414-2dv3qced	58	30	and	and	CC
cord-306414-2dv3qced	58	31	memory	memory	NN
cord-306414-2dv3qced	58	32	phenotypes	phenotype	NNS
cord-306414-2dv3qced	58	33	,	,	,
cord-306414-2dv3qced	58	34	which	which	WDT
cord-306414-2dv3qced	58	35	promote	promote	VBP
cord-306414-2dv3qced	58	36	effective	effective	JJ
cord-306414-2dv3qced	58	37	immune	immune	JJ
cord-306414-2dv3qced	58	38	responses	response	NNS
cord-306414-2dv3qced	58	39	.	.	.
cord-306414-2dv3qced	59	1	Clonotypes	clonotype	NNS
cord-306414-2dv3qced	59	2	:	:	:
cord-306414-2dv3qced	59	3	term	term	NN
cord-306414-2dv3qced	59	4	used	use	VBN
cord-306414-2dv3qced	59	5	to	to	TO
cord-306414-2dv3qced	59	6	describe	describe	VB
cord-306414-2dv3qced	59	7	a	a	DT
cord-306414-2dv3qced	59	8	unique	unique	JJ
cord-306414-2dv3qced	59	9	nucleotide	nucleotide	JJ
cord-306414-2dv3qced	59	10	sequence	sequence	NN
cord-306414-2dv3qced	59	11	that	that	WDT
cord-306414-2dv3qced	59	12	arises	arise	VBZ
cord-306414-2dv3qced	59	13	during	during	IN
cord-306414-2dv3qced	59	14	the	the	DT
cord-306414-2dv3qced	59	15	gene	gene	NN
cord-306414-2dv3qced	59	16	rearrangement	rearrangement	NN
cord-306414-2dv3qced	59	17	process	process	NN
cord-306414-2dv3qced	59	18	for	for	IN
cord-306414-2dv3qced	59	19	the	the	DT
cord-306414-2dv3qced	59	20	T	t	NN
cord-306414-2dv3qced	59	21	or	or	CC
cord-306414-2dv3qced	59	22	B	b	NN
cord-306414-2dv3qced	59	23	cell	cell	NN
cord-306414-2dv3qced	59	24	receptor	receptor	NN
cord-306414-2dv3qced	59	25	.	.	.
cord-306414-2dv3qced	60	1	Complementarity	complementarity	NN
cord-306414-2dv3qced	60	2	-	-	HYPH
cord-306414-2dv3qced	60	3	determining	determine	VBG
cord-306414-2dv3qced	60	4	region	region	NN
cord-306414-2dv3qced	60	5	3	3	CD
cord-306414-2dv3qced	60	6	(	(	-LRB-
cord-306414-2dv3qced	60	7	CDR3	CDR3	NNP
cord-306414-2dv3qced	60	8	)	)	-RRB-
cord-306414-2dv3qced	60	9	:	:	:
cord-306414-2dv3qced	60	10	antigen	antigen	NN
cord-306414-2dv3qced	60	11	binding	bind	VBG
cord-306414-2dv3qced	60	12	region	region	NN
cord-306414-2dv3qced	60	13	within	within	IN
cord-306414-2dv3qced	60	14	TCRs	tcr	NNS
cord-306414-2dv3qced	60	15	that	that	WDT
cord-306414-2dv3qced	60	16	are	be	VBP
cord-306414-2dv3qced	60	17	encoded	encode	VBN
cord-306414-2dv3qced	60	18	by	by	IN
cord-306414-2dv3qced	60	19	the	the	DT
cord-306414-2dv3qced	60	20	region	region	NN
cord-306414-2dv3qced	60	21	spanning	span	VBG
cord-306414-2dv3qced	60	22	the	the	DT
cord-306414-2dv3qced	60	23	V	V	NNP
cord-306414-2dv3qced	60	24	and	and	CC
cord-306414-2dv3qced	60	25	J	J	NNP
cord-306414-2dv3qced	60	26	for	for	IN
cord-306414-2dv3qced	60	27	the	the	DT
cord-306414-2dv3qced	60	28	alpha	alpha	NN
cord-306414-2dv3qced	60	29	subunit	subunit	NN
cord-306414-2dv3qced	60	30	or	or	CC
cord-306414-2dv3qced	60	31	the	the	DT
cord-306414-2dv3qced	60	32	V	v	NN
cord-306414-2dv3qced	60	33	,	,	,
cord-306414-2dv3qced	60	34	D	D	NNP
cord-306414-2dv3qced	60	35	,	,	,
cord-306414-2dv3qced	60	36	and	and	CC
cord-306414-2dv3qced	60	37	J	J	NNP
cord-306414-2dv3qced	60	38	junctions	junction	NNS
cord-306414-2dv3qced	60	39	for	for	IN
cord-306414-2dv3qced	60	40	the	the	DT
cord-306414-2dv3qced	60	41	beta	beta	NN
cord-306414-2dv3qced	60	42	subunit	subunit	NN
cord-306414-2dv3qced	60	43	of	of	IN
cord-306414-2dv3qced	60	44	the	the	DT
cord-306414-2dv3qced	60	45	TCR	TCR	NNP
cord-306414-2dv3qced	60	46	.	.	.
cord-306414-2dv3qced	61	1	The	the	DT
cord-306414-2dv3qced	61	2	diversity	diversity	NN
cord-306414-2dv3qced	61	3	of	of	IN
cord-306414-2dv3qced	61	4	the	the	DT
cord-306414-2dv3qced	61	5	CDR3	CDR3	NNP
cord-306414-2dv3qced	61	6	loops	loop	NNS
cord-306414-2dv3qced	61	7	is	be	VBZ
cord-306414-2dv3qced	61	8	significantly	significantly	RB
cord-306414-2dv3qced	61	9	increased	increase	VBN
cord-306414-2dv3qced	61	10	because	because	IN
cord-306414-2dv3qced	61	11	of	of	IN
cord-306414-2dv3qced	61	12	the	the	DT
cord-306414-2dv3qced	61	13	addition	addition	NN
cord-306414-2dv3qced	61	14	and	and	CC
cord-306414-2dv3qced	61	15	loss	loss	NN
cord-306414-2dv3qced	61	16	of	of	IN
cord-306414-2dv3qced	61	17	nucleotides	nucleotide	NNS
cord-306414-2dv3qced	61	18	during	during	IN
cord-306414-2dv3qced	61	19	the	the	DT
cord-306414-2dv3qced	61	20	joining	joining	NN
cord-306414-2dv3qced	61	21	process	process	NN
cord-306414-2dv3qced	61	22	.	.	.
cord-306414-2dv3qced	62	1	The	the	DT
cord-306414-2dv3qced	62	2	CDR3	CDR3	NNP
cord-306414-2dv3qced	62	3	region	region	NN
cord-306414-2dv3qced	62	4	determines	determine	VBZ
cord-306414-2dv3qced	62	5	antigen	antigen	NN
cord-306414-2dv3qced	62	6	specificity	specificity	NN
cord-306414-2dv3qced	62	7	of	of	IN
cord-306414-2dv3qced	62	8	TCRs	tcr	NNS
cord-306414-2dv3qced	62	9	.	.	.
cord-306414-2dv3qced	63	1	Coronavirus	Coronavirus	NNP
cord-306414-2dv3qced	63	2	disease	disease	NN
cord-306414-2dv3qced	63	3	(	(	-LRB-
cord-306414-2dv3qced	63	4	COVID-19	covid-19	VB
cord-306414-2dv3qced	63	5	)	)	-RRB-
cord-306414-2dv3qced	63	6	:	:	:
cord-306414-2dv3qced	63	7	infectious	infectious	JJ
cord-306414-2dv3qced	63	8	disease	disease	NN
cord-306414-2dv3qced	63	9	caused	cause	VBN
cord-306414-2dv3qced	63	10	by	by	IN
cord-306414-2dv3qced	63	11	SARS	SARS	NNP
cord-306414-2dv3qced	63	12	-	-	HYPH
cord-306414-2dv3qced	63	13	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	63	14	virus	virus	NN
cord-306414-2dv3qced	63	15	and	and	CC
cord-306414-2dv3qced	63	16	is	be	VBZ
cord-306414-2dv3qced	63	17	the	the	DT
cord-306414-2dv3qced	63	18	official	official	JJ
cord-306414-2dv3qced	63	19	name	name	NN
cord-306414-2dv3qced	63	20	given	give	VBN
cord-306414-2dv3qced	63	21	by	by	IN
cord-306414-2dv3qced	63	22	the	the	DT
cord-306414-2dv3qced	63	23	World	World	NNP
cord-306414-2dv3qced	63	24	Health	Health	NNP
cord-306414-2dv3qced	63	25	Organization	Organization	NNP
cord-306414-2dv3qced	63	26	to	to	IN
cord-306414-2dv3qced	63	27	the	the	DT
cord-306414-2dv3qced	63	28	disease	disease	NN
cord-306414-2dv3qced	63	29	caused	cause	VBN
cord-306414-2dv3qced	63	30	by	by	IN
cord-306414-2dv3qced	63	31	this	this	DT
cord-306414-2dv3qced	63	32	newly	newly	RB
cord-306414-2dv3qced	63	33	identified	identify	VBN
cord-306414-2dv3qced	63	34	coronavirus	coronavirus	NN
cord-306414-2dv3qced	63	35	.	.	.
cord-306414-2dv3qced	64	1	Cytomegalovirus	Cytomegalovirus	NNP
cord-306414-2dv3qced	64	2	(	(	-LRB-
cord-306414-2dv3qced	64	3	CMV	CMV	NNP
cord-306414-2dv3qced	64	4	)	)	-RRB-
cord-306414-2dv3qced	64	5	:	:	:
cord-306414-2dv3qced	64	6	a	a	DT
cord-306414-2dv3qced	64	7	betaherpesvirus	betaherpesvirus	NN
cord-306414-2dv3qced	64	8	,	,	,
cord-306414-2dv3qced	64	9	represents	represent	VBZ
cord-306414-2dv3qced	64	10	the	the	DT
cord-306414-2dv3qced	64	11	major	major	JJ
cord-306414-2dv3qced	64	12	infectious	infectious	JJ
cord-306414-2dv3qced	64	13	cause	cause	NN
cord-306414-2dv3qced	64	14	of	of	IN
cord-306414-2dv3qced	64	15	birth	birth	NN
cord-306414-2dv3qced	64	16	defects	defect	NNS
cord-306414-2dv3qced	64	17	,	,	,
cord-306414-2dv3qced	64	18	as	as	RB
cord-306414-2dv3qced	64	19	well	well	RB
cord-306414-2dv3qced	64	20	as	as	IN
cord-306414-2dv3qced	64	21	an	an	DT
cord-306414-2dv3qced	64	22	important	important	JJ
cord-306414-2dv3qced	64	23	pathogen	pathogen	NN
cord-306414-2dv3qced	64	24	for	for	IN
cord-306414-2dv3qced	64	25	immunocompromised	immunocompromised	JJ
cord-306414-2dv3qced	64	26	individuals	individual	NNS
cord-306414-2dv3qced	64	27	.	.	.
cord-306414-2dv3qced	65	1	The	the	DT
cord-306414-2dv3qced	65	2	viral	viral	JJ
cord-306414-2dv3qced	65	3	nucleocapsid	nucleocapsid	NN
cord-306414-2dv3qced	65	4	containing	contain	VBG
cord-306414-2dv3qced	65	5	a	a	DT
cord-306414-2dv3qced	65	6	linear	linear	JJ
cord-306414-2dv3qced	65	7	double	double	RB
cord-306414-2dv3qced	65	8	-	-	HYPH
cord-306414-2dv3qced	65	9	stranded	stranded	JJ
cord-306414-2dv3qced	65	10	DNA	dna	NN
cord-306414-2dv3qced	65	11	of	of	IN
cord-306414-2dv3qced	65	12	230	230	CD
cord-306414-2dv3qced	65	13	kb	kb	NNP
cord-306414-2dv3qced	65	14	is	be	VBZ
cord-306414-2dv3qced	65	15	surrounded	surround	VBN
cord-306414-2dv3qced	65	16	by	by	IN
cord-306414-2dv3qced	65	17	a	a	DT
cord-306414-2dv3qced	65	18	proteinaceous	proteinaceous	JJ
cord-306414-2dv3qced	65	19	tegument	tegument	NN
cord-306414-2dv3qced	65	20	that	that	WDT
cord-306414-2dv3qced	65	21	is	be	VBZ
cord-306414-2dv3qced	65	22	enclosed	enclose	VBN
cord-306414-2dv3qced	65	23	by	by	IN
cord-306414-2dv3qced	65	24	a	a	DT
cord-306414-2dv3qced	65	25	lipid	lipid	NN
cord-306414-2dv3qced	65	26	bilayer	bilayer	NN
cord-306414-2dv3qced	65	27	.	.	.
cord-306414-2dv3qced	66	1	Establishes	establish	VBZ
cord-306414-2dv3qced	66	2	lifelong	lifelong	JJ
cord-306414-2dv3qced	66	3	latent	latent	JJ
cord-306414-2dv3qced	66	4	Trends	trend	NNS
cord-306414-2dv3qced	66	5	in	in	IN
cord-306414-2dv3qced	66	6	Pharmacological	Pharmacological	NNP
cord-306414-2dv3qced	66	7	Sciences	Sciences	NNPS
cord-306414-2dv3qced	66	8	random	random	JJ
cord-306414-2dv3qced	66	9	addition	addition	NN
cord-306414-2dv3qced	66	10	and	and	CC
cord-306414-2dv3qced	66	11	deletion	deletion	NN
cord-306414-2dv3qced	66	12	of	of	IN
cord-306414-2dv3qced	66	13	nucleotides	nucleotide	NNS
cord-306414-2dv3qced	66	14	to	to	TO
cord-306414-2dv3qced	66	15	form	form	VB
cord-306414-2dv3qced	66	16	the	the	DT
cord-306414-2dv3qced	66	17	final	final	JJ
cord-306414-2dv3qced	66	18	mature	mature	JJ
cord-306414-2dv3qced	66	19	TCR	TCR	NNP
cord-306414-2dv3qced	66	20	gene	gene	NN
cord-306414-2dv3qced	66	21	[	[	-LRB-
cord-306414-2dv3qced	66	22	24	24	CD
cord-306414-2dv3qced	66	23	]	]	-RRB-
cord-306414-2dv3qced	66	24	(	(	-LRB-
cord-306414-2dv3qced	66	25	Figure	figure	NN
cord-306414-2dv3qced	66	26	2	2	CD
cord-306414-2dv3qced	66	27	)	)	-RRB-
cord-306414-2dv3qced	66	28	.	.	.
cord-306414-2dv3qced	67	1	This	this	DT
cord-306414-2dv3qced	67	2	process	process	NN
cord-306414-2dv3qced	67	3	can	can	MD
cord-306414-2dv3qced	67	4	generate	generate	VB
cord-306414-2dv3qced	67	5	up	up	IN
cord-306414-2dv3qced	67	6	to	to	TO
cord-306414-2dv3qced	67	7	10	10	CD
cord-306414-2dv3qced	67	8	15	15	CD
cord-306414-2dv3qced	67	9	unique	unique	JJ
cord-306414-2dv3qced	67	10	TCRs	tcr	NNS
cord-306414-2dv3qced	67	11	[	[	-LRB-
cord-306414-2dv3qced	67	12	25	25	CD
cord-306414-2dv3qced	67	13	,	,	,
cord-306414-2dv3qced	67	14	26	26	CD
cord-306414-2dv3qced	67	15	]	]	-RRB-
cord-306414-2dv3qced	67	16	.	.	.
cord-306414-2dv3qced	68	1	The	the	DT
cord-306414-2dv3qced	68	2	antigen	antigen	NN
cord-306414-2dv3qced	68	3	specificity	specificity	NN
cord-306414-2dv3qced	68	4	of	of	IN
cord-306414-2dv3qced	68	5	each	each	DT
cord-306414-2dv3qced	68	6	TCR	TCR	NNP
cord-306414-2dv3qced	68	7	lies	lie	VBZ
cord-306414-2dv3qced	68	8	in	in	IN
cord-306414-2dv3qced	68	9	its	-PRON-	PRP$
cord-306414-2dv3qced	68	10	complementarity	complementarity	NN
cord-306414-2dv3qced	68	11	-	-	HYPH
cord-306414-2dv3qced	68	12	determining	determine	VBG
cord-306414-2dv3qced	68	13	region	region	NN
cord-306414-2dv3qced	68	14	3	3	CD
cord-306414-2dv3qced	68	15	(	(	-LRB-
cord-306414-2dv3qced	68	16	CDR3	CDR3	NNP
cord-306414-2dv3qced	68	17	)	)	-RRB-
cord-306414-2dv3qced	68	18	,	,	,
cord-306414-2dv3qced	68	19	which	which	WDT
cord-306414-2dv3qced	68	20	is	be	VBZ
cord-306414-2dv3qced	68	21	located	locate	VBN
cord-306414-2dv3qced	68	22	at	at	IN
cord-306414-2dv3qced	68	23	the	the	DT
cord-306414-2dv3qced	68	24	V(D)J	V(D)J	NNP
cord-306414-2dv3qced	68	25	junction	junction	NN
cord-306414-2dv3qced	68	26	.	.	.
cord-306414-2dv3qced	69	1	As	as	IN
cord-306414-2dv3qced	69	2	a	a	DT
cord-306414-2dv3qced	69	3	result	result	NN
cord-306414-2dv3qced	69	4	,	,	,
cord-306414-2dv3qced	69	5	each	each	DT
cord-306414-2dv3qced	69	6	unique	unique	JJ
cord-306414-2dv3qced	69	7	T	t	NN
cord-306414-2dv3qced	69	8	cell	cell	NN
cord-306414-2dv3qced	69	9	clone	clone	NN
cord-306414-2dv3qced	69	10	is	be	VBZ
cord-306414-2dv3qced	69	11	identified	identify	VBN
cord-306414-2dv3qced	69	12	by	by	IN
cord-306414-2dv3qced	69	13	its	-PRON-	PRP$
cord-306414-2dv3qced	69	14	unique	unique	JJ
cord-306414-2dv3qced	69	15	CDR3	CDR3	NNP
cord-306414-2dv3qced	69	16	region	region	NN
cord-306414-2dv3qced	69	17	and	and	CC
cord-306414-2dv3qced	69	18	,	,	,
cord-306414-2dv3qced	69	19	therefore	therefore	RB
cord-306414-2dv3qced	69	20	,	,	,
cord-306414-2dv3qced	69	21	unique	unique	JJ
cord-306414-2dv3qced	69	22	antigen	antigen	NN
cord-306414-2dv3qced	69	23	specificity	specificity	NN
cord-306414-2dv3qced	69	24	.	.	.
cord-306414-2dv3qced	70	1	The	the	DT
cord-306414-2dv3qced	70	2	TCR	TCR	NNP
cord-306414-2dv3qced	70	3	recombination	recombination	NN
cord-306414-2dv3qced	70	4	process	process	NN
cord-306414-2dv3qced	70	5	generates	generate	VBZ
cord-306414-2dv3qced	70	6	a	a	DT
cord-306414-2dv3qced	70	7	diverse	diverse	JJ
cord-306414-2dv3qced	70	8	TCR	TCR	NNP
cord-306414-2dv3qced	70	9	repertoire	repertoire	NN
cord-306414-2dv3qced	70	10	capable	capable	JJ
cord-306414-2dv3qced	70	11	of	of	IN
cord-306414-2dv3qced	70	12	recognizing	recognize	VBG
cord-306414-2dv3qced	70	13	a	a	DT
cord-306414-2dv3qced	70	14	wide	wide	JJ
cord-306414-2dv3qced	70	15	range	range	NN
cord-306414-2dv3qced	70	16	of	of	IN
cord-306414-2dv3qced	70	17	antigens	antigen	NNS
cord-306414-2dv3qced	70	18	and	and	CC
cord-306414-2dv3qced	70	19	providing	provide	VBG
cord-306414-2dv3qced	70	20	potent	potent	JJ
cord-306414-2dv3qced	70	21	antiviral	antiviral	JJ
cord-306414-2dv3qced	70	22	immunity	immunity	NN
cord-306414-2dv3qced	70	23	[	[	-LRB-
cord-306414-2dv3qced	70	24	27	27	CD
cord-306414-2dv3qced	70	25	]	]	-RRB-
cord-306414-2dv3qced	70	26	.	.	.
cord-306414-2dv3qced	71	1	The	the	DT
cord-306414-2dv3qced	71	2	diversity	diversity	NN
cord-306414-2dv3qced	71	3	and	and	CC
cord-306414-2dv3qced	71	4	the	the	DT
cord-306414-2dv3qced	71	5	composition	composition	NN
cord-306414-2dv3qced	71	6	of	of	IN
cord-306414-2dv3qced	71	7	the	the	DT
cord-306414-2dv3qced	71	8	TCR	TCR	NNP
cord-306414-2dv3qced	71	9	repertoire	repertoire	NN
cord-306414-2dv3qced	71	10	changes	change	NNS
cord-306414-2dv3qced	71	11	in	in	IN
cord-306414-2dv3qced	71	12	response	response	NN
cord-306414-2dv3qced	71	13	to	to	IN
cord-306414-2dv3qced	71	14	acute	acute	JJ
cord-306414-2dv3qced	71	15	and	and	CC
cord-306414-2dv3qced	71	16	chronic	chronic	JJ
cord-306414-2dv3qced	71	17	infection	infection	NN
cord-306414-2dv3qced	71	18	,	,	,
cord-306414-2dv3qced	71	19	aging	aging	NN
cord-306414-2dv3qced	71	20	,	,	,
cord-306414-2dv3qced	71	21	cancer	cancer	NN
cord-306414-2dv3qced	71	22	,	,	,
cord-306414-2dv3qced	71	23	and	and	CC
cord-306414-2dv3qced	71	24	many	many	JJ
cord-306414-2dv3qced	71	25	other	other	JJ
cord-306414-2dv3qced	71	26	external	external	JJ
cord-306414-2dv3qced	71	27	and	and	CC
cord-306414-2dv3qced	71	28	internal	internal	JJ
cord-306414-2dv3qced	71	29	forces	force	NNS
cord-306414-2dv3qced	71	30	,	,	,
cord-306414-2dv3qced	71	31	making	make	VBG
cord-306414-2dv3qced	71	32	the	the	DT
cord-306414-2dv3qced	71	33	repertoire	repertoire	NN
cord-306414-2dv3qced	71	34	highly	highly	RB
cord-306414-2dv3qced	71	35	dynamic	dynamic	JJ
cord-306414-2dv3qced	71	36	.	.	.
cord-306414-2dv3qced	72	1	Exposure	exposure	NN
cord-306414-2dv3qced	72	2	to	to	IN
cord-306414-2dv3qced	72	3	antigen	antigen	NN
cord-306414-2dv3qced	72	4	triggers	trigger	VBZ
cord-306414-2dv3qced	72	5	massive	massive	JJ
cord-306414-2dv3qced	72	6	expansion	expansion	NN
cord-306414-2dv3qced	72	7	of	of	IN
cord-306414-2dv3qced	72	8	T	t	NN
cord-306414-2dv3qced	72	9	cells	cell	NNS
cord-306414-2dv3qced	72	10	capable	capable	JJ
cord-306414-2dv3qced	72	11	of	of	IN
cord-306414-2dv3qced	72	12	recognizing	recognize	VBG
cord-306414-2dv3qced	72	13	the	the	DT
cord-306414-2dv3qced	72	14	particular	particular	JJ
cord-306414-2dv3qced	72	15	antigen	antigen	NN
cord-306414-2dv3qced	72	16	(	(	-LRB-
cord-306414-2dv3qced	72	17	antigen	antigen	NN
cord-306414-2dv3qced	72	18	-	-	HYPH
cord-306414-2dv3qced	72	19	specific	specific	JJ
cord-306414-2dv3qced	72	20	T	T	NNP
cord-306414-2dv3qced	72	21	cells	cell	NNS
cord-306414-2dv3qced	72	22	)	)	-RRB-
cord-306414-2dv3qced	72	23	,	,	,
cord-306414-2dv3qced	72	24	leading	lead	VBG
cord-306414-2dv3qced	72	25	to	to	IN
cord-306414-2dv3qced	72	26	skewing	skew	VBG
cord-306414-2dv3qced	72	27	of	of	IN
cord-306414-2dv3qced	72	28	the	the	DT
cord-306414-2dv3qced	72	29	TCR	TCR	NNP
cord-306414-2dv3qced	72	30	repertoire	repertoire	NN
cord-306414-2dv3qced	72	31	(	(	-LRB-
cord-306414-2dv3qced	72	32	TCR	TCR	NNP
cord-306414-2dv3qced	72	33	bias	bias	NN
cord-306414-2dv3qced	72	34	)	)	-RRB-
cord-306414-2dv3qced	72	35	to	to	TO
cord-306414-2dv3qced	72	36	favor	favor	VB
cord-306414-2dv3qced	72	37	antigen	antigen	NN
cord-306414-2dv3qced	72	38	-	-	HYPH
cord-306414-2dv3qced	72	39	specific	specific	JJ
cord-306414-2dv3qced	72	40	T	t	NN
cord-306414-2dv3qced	72	41	cells	cell	NNS
cord-306414-2dv3qced	72	42	[	[	-LRB-
cord-306414-2dv3qced	72	43	28	28	CD
cord-306414-2dv3qced	72	44	]	]	-RRB-
cord-306414-2dv3qced	73	1	[	[	-LRB-
cord-306414-2dv3qced	73	2	29	29	CD
cord-306414-2dv3qced	73	3	]	]	-RRB-
cord-306414-2dv3qced	73	4	[	[	-LRB-
cord-306414-2dv3qced	73	5	30	30	CD
cord-306414-2dv3qced	73	6	]	]	-RRB-
cord-306414-2dv3qced	73	7	.	.	.
cord-306414-2dv3qced	74	1	Evidence	evidence	NN
cord-306414-2dv3qced	74	2	for	for	IN
cord-306414-2dv3qced	74	3	TCR	TCR	NNP
cord-306414-2dv3qced	74	4	bias	bias	NN
cord-306414-2dv3qced	74	5	in	in	IN
cord-306414-2dv3qced	74	6	antiviral	antiviral	JJ
cord-306414-2dv3qced	74	7	immunity	immunity	NN
cord-306414-2dv3qced	74	8	is	be	VBZ
cord-306414-2dv3qced	74	9	demonstrated	demonstrate	VBN
cord-306414-2dv3qced	74	10	for	for	IN
cord-306414-2dv3qced	74	11	many	many	JJ
cord-306414-2dv3qced	74	12	viral	viral	JJ
cord-306414-2dv3qced	74	13	infections	infection	NNS
cord-306414-2dv3qced	74	14	,	,	,
cord-306414-2dv3qced	74	15	such	such	JJ
cord-306414-2dv3qced	74	16	as	as	IN
cord-306414-2dv3qced	74	17	the	the	DT
cord-306414-2dv3qced	74	18	Epstein	Epstein	NNP
cord-306414-2dv3qced	74	19	-	-	HYPH
cord-306414-2dv3qced	74	20	Barr	Barr	NNP
cord-306414-2dv3qced	74	21	virus	virus	NN
cord-306414-2dv3qced	74	22	(	(	-LRB-
cord-306414-2dv3qced	74	23	EBV	EBV	NNP
cord-306414-2dv3qced	74	24	)	)	-RRB-
cord-306414-2dv3qced	74	25	and	and	CC
cord-306414-2dv3qced	74	26	influenza	influenza	NN
cord-306414-2dv3qced	74	27	.	.	.
cord-306414-2dv3qced	75	1	TCR	TCR	NNP
cord-306414-2dv3qced	75	2	analysis	analysis	NN
cord-306414-2dv3qced	75	3	of	of	IN
cord-306414-2dv3qced	75	4	peripheral	peripheral	JJ
cord-306414-2dv3qced	75	5	blood	blood	NN
cord-306414-2dv3qced	75	6	lymphocytes	lymphocyte	NNS
cord-306414-2dv3qced	75	7	from	from	IN
cord-306414-2dv3qced	75	8	either	either	CC
cord-306414-2dv3qced	75	9	EBV	EBV	NNP
cord-306414-2dv3qced	75	10	-	-	HYPH
cord-306414-2dv3qced	75	11	positive	positive	JJ
cord-306414-2dv3qced	75	12	or	or	CC
cord-306414-2dv3qced	75	13	influenza	influenza	NN
cord-306414-2dv3qced	75	14	-	-	HYPH
cord-306414-2dv3qced	75	15	positive	positive	JJ
cord-306414-2dv3qced	75	16	individuals	individual	NNS
cord-306414-2dv3qced	75	17	has	have	VBZ
cord-306414-2dv3qced	75	18	revealed	reveal	VBN
cord-306414-2dv3qced	75	19	several	several	JJ
cord-306414-2dv3qced	75	20	T	T	NNP
cord-306414-2dv3qced	75	21	cell	cell	NN
cord-306414-2dv3qced	75	22	clonotypes	clonotype	NNS
cord-306414-2dv3qced	75	23	with	with	IN
cord-306414-2dv3qced	75	24	recurrent	recurrent	JJ
cord-306414-2dv3qced	75	25	TCR	TCR	NNP
cord-306414-2dv3qced	75	26	motifs	motif	NNS
cord-306414-2dv3qced	75	27	shared	share	VBN
cord-306414-2dv3qced	75	28	by	by	IN
cord-306414-2dv3qced	75	29	individuals	individual	NNS
cord-306414-2dv3qced	75	30	[	[	-LRB-
cord-306414-2dv3qced	75	31	31	31	CD
cord-306414-2dv3qced	75	32	]	]	-RRB-
cord-306414-2dv3qced	75	33	[	[	-LRB-
cord-306414-2dv3qced	75	34	32	32	CD
cord-306414-2dv3qced	75	35	]	]	-RRB-
cord-306414-2dv3qced	75	36	[	[	-LRB-
cord-306414-2dv3qced	75	37	33	33	CD
cord-306414-2dv3qced	75	38	]	]	-RRB-
cord-306414-2dv3qced	75	39	.	.	.
cord-306414-2dv3qced	76	1	In	in	IN
cord-306414-2dv3qced	76	2	addition	addition	NN
cord-306414-2dv3qced	76	3	,	,	,
cord-306414-2dv3qced	76	4	the	the	DT
cord-306414-2dv3qced	76	5	expansion	expansion	NN
cord-306414-2dv3qced	76	6	and	and	CC
cord-306414-2dv3qced	76	7	maintenance	maintenance	NN
cord-306414-2dv3qced	76	8	of	of	IN
cord-306414-2dv3qced	76	9	TCRs	tcr	NNS
cord-306414-2dv3qced	76	10	during	during	IN
cord-306414-2dv3qced	76	11	chronic	chronic	JJ
cord-306414-2dv3qced	76	12	cytomegalovirus	cytomegalovirus	NN
cord-306414-2dv3qced	76	13	(	(	-LRB-
cord-306414-2dv3qced	76	14	CMV	CMV	NNP
cord-306414-2dv3qced	76	15	)	)	-RRB-
cord-306414-2dv3qced	76	16	infection	infection	NN
cord-306414-2dv3qced	76	17	demonstrates	demonstrate	VBZ
cord-306414-2dv3qced	76	18	the	the	DT
cord-306414-2dv3qced	76	19	dynamic	dynamic	JJ
cord-306414-2dv3qced	76	20	and	and	CC
cord-306414-2dv3qced	76	21	evolving	evolve	VBG
cord-306414-2dv3qced	76	22	nature	nature	NN
cord-306414-2dv3qced	76	23	of	of	IN
cord-306414-2dv3qced	76	24	the	the	DT
cord-306414-2dv3qced	76	25	TCR	TCR	NNP
cord-306414-2dv3qced	76	26	repertoire	repertoire	NN
cord-306414-2dv3qced	76	27	in	in	IN
cord-306414-2dv3qced	76	28	response	response	NN
cord-306414-2dv3qced	76	29	to	to	IN
cord-306414-2dv3qced	76	30	viral	viral	JJ
cord-306414-2dv3qced	76	31	infection	infection	NN
cord-306414-2dv3qced	76	32	[	[	-LRB-
cord-306414-2dv3qced	76	33	34	34	CD
cord-306414-2dv3qced	76	34	]	]	-RRB-
cord-306414-2dv3qced	76	35	.	.	.
cord-306414-2dv3qced	77	1	Therefore	therefore	RB
cord-306414-2dv3qced	77	2	,	,	,
cord-306414-2dv3qced	77	3	it	-PRON-	PRP
cord-306414-2dv3qced	77	4	stands	stand	VBZ
cord-306414-2dv3qced	77	5	to	to	TO
cord-306414-2dv3qced	77	6	reason	reason	VB
cord-306414-2dv3qced	77	7	that	that	IN
cord-306414-2dv3qced	77	8	the	the	DT
cord-306414-2dv3qced	77	9	presence	presence	NN
cord-306414-2dv3qced	77	10	of	of	IN
cord-306414-2dv3qced	77	11	a	a	DT
cord-306414-2dv3qced	77	12	bias	bias	NN
cord-306414-2dv3qced	77	13	exists	exist	VBZ
cord-306414-2dv3qced	77	14	in	in	IN
cord-306414-2dv3qced	77	15	the	the	DT
cord-306414-2dv3qced	77	16	TCR	TCR	NNP
cord-306414-2dv3qced	77	17	repertoire	repertoire	NN
cord-306414-2dv3qced	77	18	as	as	IN
cord-306414-2dv3qced	77	19	a	a	DT
cord-306414-2dv3qced	77	20	result	result	NN
cord-306414-2dv3qced	77	21	of	of	IN
cord-306414-2dv3qced	77	22	the	the	DT
cord-306414-2dv3qced	77	23	SARS	SARS	NNP
cord-306414-2dv3qced	77	24	-	-	HYPH
cord-306414-2dv3qced	77	25	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	77	26	infection	infection	NN
cord-306414-2dv3qced	77	27	.	.	.
cord-306414-2dv3qced	78	1	The	the	DT
cord-306414-2dv3qced	78	2	characteristics	characteristic	NNS
cord-306414-2dv3qced	78	3	of	of	IN
cord-306414-2dv3qced	78	4	the	the	DT
cord-306414-2dv3qced	78	5	TCR	TCR	NNP
cord-306414-2dv3qced	78	6	repertoire	repertoire	NN
cord-306414-2dv3qced	78	7	,	,	,
cord-306414-2dv3qced	78	8	such	such	JJ
cord-306414-2dv3qced	78	9	as	as	IN
cord-306414-2dv3qced	78	10	diversity	diversity	NN
cord-306414-2dv3qced	78	11	,	,	,
cord-306414-2dv3qced	78	12	composition	composition	NN
cord-306414-2dv3qced	78	13	,	,	,
cord-306414-2dv3qced	78	14	and	and	CC
cord-306414-2dv3qced	78	15	dynamics	dynamic	NNS
cord-306414-2dv3qced	78	16	,	,	,
cord-306414-2dv3qced	78	17	are	be	VBP
cord-306414-2dv3qced	78	18	controlled	control	VBN
cord-306414-2dv3qced	78	19	by	by	IN
cord-306414-2dv3qced	78	20	both	both	DT
cord-306414-2dv3qced	78	21	genetic	genetic	JJ
cord-306414-2dv3qced	78	22	and	and	CC
cord-306414-2dv3qced	78	23	epigenetic	epigenetic	JJ
cord-306414-2dv3qced	78	24	factors	factor	NNS
cord-306414-2dv3qced	78	25	,	,	,
cord-306414-2dv3qced	78	26	leading	lead	VBG
cord-306414-2dv3qced	78	27	to	to	IN
cord-306414-2dv3qced	78	28	interindividual	interindividual	JJ
cord-306414-2dv3qced	78	29	variability	variability	NN
cord-306414-2dv3qced	78	30	.	.	.
cord-306414-2dv3qced	79	1	Here	here	RB
cord-306414-2dv3qced	79	2	we	-PRON-	PRP
cord-306414-2dv3qced	79	3	discuss	discuss	VBP
cord-306414-2dv3qced	79	4	two	two	CD
cord-306414-2dv3qced	79	5	factors	factor	NNS
cord-306414-2dv3qced	79	6	that	that	WDT
cord-306414-2dv3qced	79	7	we	-PRON-	PRP
cord-306414-2dv3qced	79	8	believe	believe	VBP
cord-306414-2dv3qced	79	9	are	be	VBP
cord-306414-2dv3qced	79	10	relevant	relevant	JJ
cord-306414-2dv3qced	79	11	to	to	IN
cord-306414-2dv3qced	79	12	COVID-19	covid-19	VB
cord-306414-2dv3qced	79	13	and	and	CC
cord-306414-2dv3qced	79	14	the	the	DT
cord-306414-2dv3qced	79	15	observed	observed	JJ
cord-306414-2dv3qced	79	16	immune	immune	JJ
cord-306414-2dv3qced	79	17	response	response	NN
cord-306414-2dv3qced	79	18	disparities	disparity	NNS
cord-306414-2dv3qced	79	19	among	among	IN
cord-306414-2dv3qced	79	20	patients	patient	NNS
cord-306414-2dv3qced	79	21	.	.	.
cord-306414-2dv3qced	80	1	Aging	age	VBG
cord-306414-2dv3qced	80	2	of	of	IN
cord-306414-2dv3qced	80	3	the	the	DT
cord-306414-2dv3qced	80	4	TCR	TCR	NNP
cord-306414-2dv3qced	80	5	Repertoire	repertoire	NN
cord-306414-2dv3qced	81	1	It	-PRON-	PRP
cord-306414-2dv3qced	81	2	is	be	VBZ
cord-306414-2dv3qced	81	3	well	well	RB
cord-306414-2dv3qced	81	4	known	know	VBN
cord-306414-2dv3qced	81	5	that	that	IN
cord-306414-2dv3qced	81	6	TCR	TCR	NNP
cord-306414-2dv3qced	81	7	repertoire	repertoire	NN
cord-306414-2dv3qced	81	8	diversity	diversity	NN
cord-306414-2dv3qced	81	9	declines	decline	VBZ
cord-306414-2dv3qced	81	10	with	with	IN
cord-306414-2dv3qced	81	11	aging	age	VBG
cord-306414-2dv3qced	81	12	.	.	.
cord-306414-2dv3qced	82	1	This	this	DT
cord-306414-2dv3qced	82	2	decrease	decrease	NN
cord-306414-2dv3qced	82	3	in	in	IN
cord-306414-2dv3qced	82	4	TCR	TCR	NNP
cord-306414-2dv3qced	82	5	diversity	diversity	NN
cord-306414-2dv3qced	82	6	as	as	IN
cord-306414-2dv3qced	82	7	we	-PRON-	PRP
cord-306414-2dv3qced	82	8	age	age	NN
cord-306414-2dv3qced	82	9	has	have	VBZ
cord-306414-2dv3qced	82	10	also	also	RB
cord-306414-2dv3qced	82	11	been	be	VBN
cord-306414-2dv3qced	82	12	demonstrated	demonstrate	VBN
cord-306414-2dv3qced	82	13	in	in	IN
cord-306414-2dv3qced	82	14	various	various	JJ
cord-306414-2dv3qced	82	15	studies	study	NNS
cord-306414-2dv3qced	82	16	using	use	VBG
cord-306414-2dv3qced	82	17	high	high	JJ
cord-306414-2dv3qced	82	18	-	-	HYPH
cord-306414-2dv3qced	82	19	throughput	throughput	NN
cord-306414-2dv3qced	82	20	sequencing	sequencing	NN
cord-306414-2dv3qced	82	21	[	[	-LRB-
cord-306414-2dv3qced	82	22	TCR	TCR	NNP
cord-306414-2dv3qced	82	23	sequencing	sequencing	NN
cord-306414-2dv3qced	82	24	(	(	-LRB-
cord-306414-2dv3qced	82	25	TCR	TCR	NNP
cord-306414-2dv3qced	82	26	-	-	HYPH
cord-306414-2dv3qced	82	27	seq	seq	NNP
cord-306414-2dv3qced	82	28	)	)	-RRB-
cord-306414-2dv3qced	82	29	]	]	-RRB-
cord-306414-2dv3qced	82	30	technology	technology	NN
cord-306414-2dv3qced	82	31	.	.	.
cord-306414-2dv3qced	83	1	One	one	CD
cord-306414-2dv3qced	83	2	study	study	NN
cord-306414-2dv3qced	83	3	estimated	estimate	VBD
cord-306414-2dv3qced	83	4	the	the	DT
cord-306414-2dv3qced	83	5	TCRβ	TCRβ	NNS
cord-306414-2dv3qced	83	6	diversity	diversity	NN
cord-306414-2dv3qced	83	7	in	in	IN
cord-306414-2dv3qced	83	8	naïve	naïve	JJ
cord-306414-2dv3qced	83	9	T	t	NN
cord-306414-2dv3qced	83	10	cell	cell	NN
cord-306414-2dv3qced	83	11	repertoires	repertoire	NNS
cord-306414-2dv3qced	83	12	was	be	VBD
cord-306414-2dv3qced	83	13	60	60	CD
cord-306414-2dv3qced	83	14	-	-	SYM
cord-306414-2dv3qced	83	15	120	120	CD
cord-306414-2dv3qced	83	16	million	million	CD
cord-306414-2dv3qced	83	17	for	for	IN
cord-306414-2dv3qced	83	18	individuals	individual	NNS
cord-306414-2dv3qced	83	19	in	in	IN
cord-306414-2dv3qced	83	20	the	the	DT
cord-306414-2dv3qced	83	21	first	first	JJ
cord-306414-2dv3qced	83	22	two	two	CD
cord-306414-2dv3qced	83	23	decades	decade	NNS
cord-306414-2dv3qced	83	24	of	of	IN
cord-306414-2dv3qced	83	25	life	life	NN
cord-306414-2dv3qced	83	26	and	and	CC
cord-306414-2dv3qced	83	27	declined	decline	VBD
cord-306414-2dv3qced	83	28	to	to	IN
cord-306414-2dv3qced	83	29	8	8	CD
cord-306414-2dv3qced	83	30	-	-	SYM
cord-306414-2dv3qced	83	31	57	57	CD
cord-306414-2dv3qced	83	32	million	million	CD
cord-306414-2dv3qced	83	33	in	in	IN
cord-306414-2dv3qced	83	34	individuals	individual	NNS
cord-306414-2dv3qced	83	35	over	over	IN
cord-306414-2dv3qced	83	36	70	70	CD
cord-306414-2dv3qced	83	37	years	year	NNS
cord-306414-2dv3qced	83	38	old	old	JJ
cord-306414-2dv3qced	83	39	[	[	-LRB-
cord-306414-2dv3qced	83	40	35	35	CD
cord-306414-2dv3qced	83	41	]	]	-RRB-
cord-306414-2dv3qced	83	42	.	.	.
cord-306414-2dv3qced	84	1	The	the	DT
cord-306414-2dv3qced	84	2	evidence	evidence	NN
cord-306414-2dv3qced	84	3	of	of	IN
cord-306414-2dv3qced	84	4	aging	age	VBG
cord-306414-2dv3qced	84	5	TCR	TCR	NNP
cord-306414-2dv3qced	84	6	repertoire	repertoire	NN
cord-306414-2dv3qced	84	7	is	be	VBZ
cord-306414-2dv3qced	84	8	demonstrated	demonstrate	VBN
cord-306414-2dv3qced	84	9	in	in	IN
cord-306414-2dv3qced	84	10	the	the	DT
cord-306414-2dv3qced	84	11	antiviral	antiviral	JJ
cord-306414-2dv3qced	84	12	response	response	NN
cord-306414-2dv3qced	84	13	against	against	IN
cord-306414-2dv3qced	84	14	the	the	DT
cord-306414-2dv3qced	84	15	human	human	JJ
cord-306414-2dv3qced	84	16	influenza	influenza	NN
cord-306414-2dv3qced	84	17	A	a	DT
cord-306414-2dv3qced	84	18	virus	virus	NN
cord-306414-2dv3qced	84	19	[	[	-LRB-
cord-306414-2dv3qced	84	20	39	39	CD
cord-306414-2dv3qced	84	21	,	,	,
cord-306414-2dv3qced	84	22	40	40	CD
cord-306414-2dv3qced	84	23	]	]	-RRB-
cord-306414-2dv3qced	84	24	.	.	.
cord-306414-2dv3qced	85	1	This	this	DT
cord-306414-2dv3qced	85	2	may	may	MD
cord-306414-2dv3qced	85	3	be	be	VB
cord-306414-2dv3qced	85	4	of	of	IN
cord-306414-2dv3qced	85	5	particular	particular	JJ
cord-306414-2dv3qced	85	6	interest	interest	NN
cord-306414-2dv3qced	85	7	in	in	IN
cord-306414-2dv3qced	85	8	the	the	DT
cord-306414-2dv3qced	85	9	context	context	NN
cord-306414-2dv3qced	85	10	of	of	IN
cord-306414-2dv3qced	85	11	COVID-19	COVID-19	NNP
cord-306414-2dv3qced	85	12	,	,	,
cord-306414-2dv3qced	85	13	considering	consider	VBG
cord-306414-2dv3qced	85	14	that	that	IN
cord-306414-2dv3qced	85	15	the	the	DT
cord-306414-2dv3qced	85	16	mortality	mortality	NN
cord-306414-2dv3qced	85	17	of	of	IN
cord-306414-2dv3qced	85	18	elderly	elderly	JJ
cord-306414-2dv3qced	85	19	patients	patient	NNS
cord-306414-2dv3qced	85	20	with	with	IN
cord-306414-2dv3qced	85	21	COVID-19	COVID-19	NNP
cord-306414-2dv3qced	85	22	is	be	VBZ
cord-306414-2dv3qced	85	23	higher	high	JJR
cord-306414-2dv3qced	85	24	than	than	IN
cord-306414-2dv3qced	85	25	that	that	DT
cord-306414-2dv3qced	85	26	of	of	IN
cord-306414-2dv3qced	85	27	young	young	JJ
cord-306414-2dv3qced	85	28	and	and	CC
cord-306414-2dv3qced	85	29	middle	middle	JJ
cord-306414-2dv3qced	85	30	-	-	HYPH
cord-306414-2dv3qced	85	31	aged	aged	JJ
cord-306414-2dv3qced	85	32	patients	patient	NNS
cord-306414-2dv3qced	85	33	[	[	-LRB-
cord-306414-2dv3qced	85	34	3	3	CD
cord-306414-2dv3qced	85	35	,	,	,
cord-306414-2dv3qced	85	36	[	[	-LRB-
cord-306414-2dv3qced	85	37	36	36	CD
cord-306414-2dv3qced	85	38	]	]	-RRB-
cord-306414-2dv3qced	85	39	[	[	-LRB-
cord-306414-2dv3qced	85	40	37	37	CD
cord-306414-2dv3qced	85	41	]	]	-RRB-
cord-306414-2dv3qced	85	42	[	[	-LRB-
cord-306414-2dv3qced	85	43	38	38	CD
cord-306414-2dv3qced	85	44	]	]	-RRB-
cord-306414-2dv3qced	85	45	.	.	.
cord-306414-2dv3qced	86	1	Whether	whether	IN
cord-306414-2dv3qced	86	2	the	the	DT
cord-306414-2dv3qced	86	3	aged	aged	JJ
cord-306414-2dv3qced	86	4	and	and	CC
cord-306414-2dv3qced	86	5	less	less	RBR
cord-306414-2dv3qced	86	6	diverse	diverse	JJ
cord-306414-2dv3qced	86	7	TCR	TCR	NNP
cord-306414-2dv3qced	86	8	repertoire	repertoire	NN
cord-306414-2dv3qced	86	9	impacts	impact	VBZ
cord-306414-2dv3qced	86	10	the	the	DT
cord-306414-2dv3qced	86	11	ability	ability	NN
cord-306414-2dv3qced	86	12	to	to	TO
cord-306414-2dv3qced	86	13	generate	generate	VB
cord-306414-2dv3qced	86	14	a	a	DT
cord-306414-2dv3qced	86	15	sufficiently	sufficiently	RB
cord-306414-2dv3qced	86	16	robust	robust	JJ
cord-306414-2dv3qced	86	17	T	T	NNP
cord-306414-2dv3qced	86	18	cell	cell	NN
cord-306414-2dv3qced	86	19	response	response	NN
cord-306414-2dv3qced	86	20	against	against	IN
cord-306414-2dv3qced	86	21	SARS	SARS	NNP
cord-306414-2dv3qced	86	22	-	-	HYPH
cord-306414-2dv3qced	86	23	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	86	24	in	in	IN
cord-306414-2dv3qced	86	25	older	old	JJR
cord-306414-2dv3qced	86	26	patients	patient	NNS
cord-306414-2dv3qced	86	27	remains	remain	VBZ
cord-306414-2dv3qced	86	28	to	to	TO
cord-306414-2dv3qced	86	29	be	be	VB
cord-306414-2dv3qced	86	30	studied	study	VBN
cord-306414-2dv3qced	86	31	.	.	.
cord-306414-2dv3qced	87	1	Genetic	Genetic	NNP
cord-306414-2dv3qced	87	2	Variabilities	Variabilities	NNP
cord-306414-2dv3qced	87	3	in	in	IN
cord-306414-2dv3qced	87	4	the	the	DT
cord-306414-2dv3qced	87	5	HLA	HLA	NNP
cord-306414-2dv3qced	87	6	Genetic	Genetic	NNP
cord-306414-2dv3qced	87	7	differences	difference	NNS
cord-306414-2dv3qced	87	8	in	in	IN
cord-306414-2dv3qced	87	9	the	the	DT
cord-306414-2dv3qced	87	10	HLA	HLA	NNP
cord-306414-2dv3qced	87	11	genes	gene	NNS
cord-306414-2dv3qced	87	12	are	be	VBP
cord-306414-2dv3qced	87	13	well	well	RB
cord-306414-2dv3qced	87	14	known	know	VBN
cord-306414-2dv3qced	87	15	to	to	TO
cord-306414-2dv3qced	87	16	influence	influence	VB
cord-306414-2dv3qced	87	17	the	the	DT
cord-306414-2dv3qced	87	18	composition	composition	NN
cord-306414-2dv3qced	87	19	of	of	IN
cord-306414-2dv3qced	87	20	TCR	TCR	NNP
cord-306414-2dv3qced	87	21	repertoire	repertoire	NN
cord-306414-2dv3qced	87	22	by	by	IN
cord-306414-2dv3qced	87	23	affecting	affect	VBG
cord-306414-2dv3qced	87	24	intra	intra	JJ
cord-306414-2dv3qced	87	25	-	-	HYPH
cord-306414-2dv3qced	87	26	and	and	CC
cord-306414-2dv3qced	87	27	extrathymic	extrathymic	JJ
cord-306414-2dv3qced	87	28	clonal	clonal	JJ
cord-306414-2dv3qced	87	29	selection	selection	NN
cord-306414-2dv3qced	87	30	,	,	,
cord-306414-2dv3qced	87	31	partially	partially	RB
cord-306414-2dv3qced	87	32	accounting	account	VBG
cord-306414-2dv3qced	87	33	for	for	IN
cord-306414-2dv3qced	87	34	individual	individual	JJ
cord-306414-2dv3qced	87	35	variations	variation	NNS
cord-306414-2dv3qced	87	36	in	in	IN
cord-306414-2dv3qced	87	37	the	the	DT
cord-306414-2dv3qced	87	38	immune	immune	JJ
cord-306414-2dv3qced	87	39	response	response	NN
cord-306414-2dv3qced	87	40	to	to	IN
cord-306414-2dv3qced	87	41	pathogens	pathogen	NNS
cord-306414-2dv3qced	87	42	[	[	-LRB-
cord-306414-2dv3qced	87	43	41	41	CD
cord-306414-2dv3qced	87	44	]	]	-RRB-
cord-306414-2dv3qced	88	1	[	[	-LRB-
cord-306414-2dv3qced	88	2	42	42	CD
cord-306414-2dv3qced	88	3	]	]	-RRB-
cord-306414-2dv3qced	88	4	[	[	-LRB-
cord-306414-2dv3qced	88	5	43	43	CD
cord-306414-2dv3qced	88	6	]	]	-RRB-
cord-306414-2dv3qced	88	7	.	.	.
cord-306414-2dv3qced	89	1	These	these	DT
cord-306414-2dv3qced	89	2	genetic	genetic	JJ
cord-306414-2dv3qced	89	3	differences	difference	NNS
cord-306414-2dv3qced	89	4	in	in	IN
cord-306414-2dv3qced	89	5	the	the	DT
cord-306414-2dv3qced	89	6	HLA	HLA	NNP
cord-306414-2dv3qced	89	7	genes	gene	NNS
cord-306414-2dv3qced	89	8	directly	directly	RB
cord-306414-2dv3qced	89	9	affect	affect	VBP
cord-306414-2dv3qced	89	10	the	the	DT
cord-306414-2dv3qced	89	11	binding	bind	VBG
cord-306414-2dv3qced	89	12	affinity	affinity	NN
cord-306414-2dv3qced	89	13	of	of	IN
cord-306414-2dv3qced	89	14	MHC	MHC	NNP
cord-306414-2dv3qced	89	15	I	I	NNP
cord-306414-2dv3qced	89	16	/	/	SYM
cord-306414-2dv3qced	89	17	II	II	NNP
cord-306414-2dv3qced	89	18	molecules	molecule	NNS
cord-306414-2dv3qced	89	19	to	to	IN
cord-306414-2dv3qced	89	20	antigens	antigen	NNS
cord-306414-2dv3qced	89	21	and	and	CC
cord-306414-2dv3qced	89	22	,	,	,
cord-306414-2dv3qced	89	23	consequently	consequently	RB
cord-306414-2dv3qced	89	24	,	,	,
cord-306414-2dv3qced	89	25	influence	influence	VB
cord-306414-2dv3qced	89	26	T	T	NNP
cord-306414-2dv3qced	89	27	cell	cell	NN
cord-306414-2dv3qced	89	28	recognition	recognition	NN
cord-306414-2dv3qced	89	29	of	of	IN
cord-306414-2dv3qced	89	30	pathogen	pathogen	NN
cord-306414-2dv3qced	89	31	-	-	HYPH
cord-306414-2dv3qced	89	32	derived	derive	VBN
cord-306414-2dv3qced	89	33	antigens	antigen	NNS
cord-306414-2dv3qced	89	34	[	[	-LRB-
cord-306414-2dv3qced	89	35	44	44	CD
cord-306414-2dv3qced	89	36	]	]	-RRB-
cord-306414-2dv3qced	89	37	[	[	-LRB-
cord-306414-2dv3qced	89	38	45	45	CD
cord-306414-2dv3qced	89	39	]	]	-RRB-
cord-306414-2dv3qced	89	40	[	[	-LRB-
cord-306414-2dv3qced	89	41	46	46	CD
cord-306414-2dv3qced	89	42	]	]	-RRB-
cord-306414-2dv3qced	89	43	[	[	-LRB-
cord-306414-2dv3qced	89	44	47	47	CD
cord-306414-2dv3qced	89	45	]	]	-RRB-
cord-306414-2dv3qced	89	46	.	.	.
cord-306414-2dv3qced	90	1	One	one	CD
cord-306414-2dv3qced	90	2	study	study	NN
cord-306414-2dv3qced	90	3	conducted	conduct	VBD
cord-306414-2dv3qced	90	4	a	a	DT
cord-306414-2dv3qced	90	5	comprehensive	comprehensive	JJ
cord-306414-2dv3qced	90	6	in	in	IN
cord-306414-2dv3qced	90	7	silico	silico	NN
cord-306414-2dv3qced	90	8	analysis	analysis	NN
cord-306414-2dv3qced	90	9	of	of	IN
cord-306414-2dv3qced	90	10	viral	viral	JJ
cord-306414-2dv3qced	90	11	peptide	peptide	NN
cord-306414-2dv3qced	90	12	-	-	HYPH
cord-306414-2dv3qced	90	13	MHC	MHC	NNP
cord-306414-2dv3qced	90	14	class	class	NN
cord-306414-2dv3qced	90	15	I	-PRON-	PRP
cord-306414-2dv3qced	90	16	binding	bind	VBG
cord-306414-2dv3qced	90	17	affinity	affinity	NN
cord-306414-2dv3qced	90	18	across	across	IN
cord-306414-2dv3qced	90	19	over	over	IN
cord-306414-2dv3qced	90	20	a	a	DT
cord-306414-2dv3qced	90	21	hundred	hundred	CD
cord-306414-2dv3qced	90	22	HLA	HLA	NNP
cord-306414-2dv3qced	90	23	-A	-A	NNS
cord-306414-2dv3qced	90	24	,	,	,
cord-306414-2dv3qced	90	25	-B	-b	ADD
cord-306414-2dv3qced	90	26	,	,	,
cord-306414-2dv3qced	90	27	and	and	CC
cord-306414-2dv3qced	90	28	-C	-C	VBZ
cord-306414-2dv3qced	90	29	genotypes	genotype	NNS
cord-306414-2dv3qced	90	30	for	for	IN
cord-306414-2dv3qced	90	31	all	all	DT
cord-306414-2dv3qced	90	32	SARS	SARS	NNP
cord-306414-2dv3qced	90	33	-	-	HYPH
cord-306414-2dv3qced	90	34	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	90	35	peptides	peptide	NNS
cord-306414-2dv3qced	90	36	.	.	.
cord-306414-2dv3qced	91	1	It	-PRON-	PRP
cord-306414-2dv3qced	91	2	showed	show	VBD
cord-306414-2dv3qced	91	3	that	that	IN
cord-306414-2dv3qced	91	4	HLA	HLA	NNP
cord-306414-2dv3qced	91	5	-	-	HYPH
cord-306414-2dv3qced	91	6	B*46:01	B*46:01	NNP
cord-306414-2dv3qced	91	7	had	have	VBD
cord-306414-2dv3qced	91	8	the	the	DT
cord-306414-2dv3qced	91	9	fewest	few	JJS
cord-306414-2dv3qced	91	10	predicted	predict	VBN
cord-306414-2dv3qced	91	11	binding	bind	VBG
cord-306414-2dv3qced	91	12	peptides	peptide	NNS
cord-306414-2dv3qced	91	13	for	for	IN
cord-306414-2dv3qced	91	14	SARS	SARS	NNP
cord-306414-2dv3qced	91	15	-	-	HYPH
cord-306414-2dv3qced	91	16	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	91	17	,	,	,
cord-306414-2dv3qced	91	18	suggesting	suggest	VBG
cord-306414-2dv3qced	91	19	higher	high	JJR
cord-306414-2dv3qced	91	20	vulnerability	vulnerability	NN
cord-306414-2dv3qced	91	21	to	to	IN
cord-306414-2dv3qced	91	22	COVID-19	covid-19	VB
cord-306414-2dv3qced	91	23	among	among	IN
cord-306414-2dv3qced	91	24	individuals	individual	NNS
cord-306414-2dv3qced	91	25	with	with	IN
cord-306414-2dv3qced	91	26	this	this	DT
cord-306414-2dv3qced	91	27	allele	allele	NN
cord-306414-2dv3qced	91	28	[	[	-LRB-
cord-306414-2dv3qced	91	29	48	48	CD
cord-306414-2dv3qced	91	30	]	]	-RRB-
cord-306414-2dv3qced	91	31	.	.	.
cord-306414-2dv3qced	92	1	The	the	DT
cord-306414-2dv3qced	92	2	same	same	JJ
cord-306414-2dv3qced	92	3	allele	allele	NN
cord-306414-2dv3qced	92	4	was	be	VBD
cord-306414-2dv3qced	92	5	previously	previously	RB
cord-306414-2dv3qced	92	6	associated	associate	VBN
cord-306414-2dv3qced	92	7	with	with	IN
cord-306414-2dv3qced	92	8	susceptibility	susceptibility	NN
cord-306414-2dv3qced	92	9	to	to	IN
cord-306414-2dv3qced	92	10	SARS	SARS	NNP
cord-306414-2dv3qced	92	11	[	[	-LRB-
cord-306414-2dv3qced	92	12	49	49	CD
cord-306414-2dv3qced	92	13	]	]	-RRB-
cord-306414-2dv3qced	92	14	.	.	.
cord-306414-2dv3qced	93	1	In	in	IN
cord-306414-2dv3qced	93	2	contrast	contrast	NN
cord-306414-2dv3qced	93	3	,	,	,
cord-306414-2dv3qced	93	4	HLA	HLA	NNP
cord-306414-2dv3qced	93	5	-	-	HYPH
cord-306414-2dv3qced	93	6	B*15:03	B*15:03	NNP
cord-306414-2dv3qced	93	7	was	be	VBD
cord-306414-2dv3qced	93	8	found	find	VBN
cord-306414-2dv3qced	93	9	to	to	TO
cord-306414-2dv3qced	93	10	have	have	VB
cord-306414-2dv3qced	93	11	the	the	DT
cord-306414-2dv3qced	93	12	greatest	great	JJS
cord-306414-2dv3qced	93	13	capacity	capacity	NN
cord-306414-2dv3qced	93	14	to	to	TO
cord-306414-2dv3qced	93	15	present	present	VB
cord-306414-2dv3qced	93	16	infection	infection	NN
cord-306414-2dv3qced	93	17	and	and	CC
cord-306414-2dv3qced	93	18	is	be	VBZ
cord-306414-2dv3qced	93	19	reactivated	reactivate	VBN
cord-306414-2dv3qced	93	20	by	by	IN
cord-306414-2dv3qced	93	21	immunosuppression	immunosuppression	NN
cord-306414-2dv3qced	93	22	.	.	.
cord-306414-2dv3qced	94	1	Dendritic	dendritic	JJ
cord-306414-2dv3qced	94	2	cells	cell	NNS
cord-306414-2dv3qced	94	3	:	:	:
cord-306414-2dv3qced	94	4	professional	professional	JJ
cord-306414-2dv3qced	94	5	antigenpresenting	antigenpresenting	NN
cord-306414-2dv3qced	94	6	cells	cell	NNS
cord-306414-2dv3qced	94	7	,	,	,
cord-306414-2dv3qced	94	8	uniquely	uniquely	RB
cord-306414-2dv3qced	94	9	able	able	JJ
cord-306414-2dv3qced	94	10	to	to	TO
cord-306414-2dv3qced	94	11	induce	induce	VB
cord-306414-2dv3qced	94	12	naïve	naïve	JJ
cord-306414-2dv3qced	94	13	T	T	NNP
cord-306414-2dv3qced	94	14	cell	cell	NN
cord-306414-2dv3qced	94	15	activation	activation	NN
cord-306414-2dv3qced	94	16	and	and	CC
cord-306414-2dv3qced	94	17	effector	effector	NN
cord-306414-2dv3qced	94	18	differentiation	differentiation	NN
cord-306414-2dv3qced	94	19	.	.	.
cord-306414-2dv3qced	95	1	Epstein	Epstein	NNP
cord-306414-2dv3qced	95	2	-	-	HYPH
cord-306414-2dv3qced	95	3	Barr	Barr	NNP
cord-306414-2dv3qced	95	4	virus	virus	NN
cord-306414-2dv3qced	95	5	(	(	-LRB-
cord-306414-2dv3qced	95	6	EBV	EBV	NNP
cord-306414-2dv3qced	95	7	)	)	-RRB-
cord-306414-2dv3qced	95	8	:	:	:
cord-306414-2dv3qced	95	9	a	a	DT
cord-306414-2dv3qced	95	10	human	human	JJ
cord-306414-2dv3qced	95	11	herpesvirus	herpesvirus	NN
cord-306414-2dv3qced	95	12	4	4	CD
cord-306414-2dv3qced	95	13	with	with	IN
cord-306414-2dv3qced	95	14	a	a	DT
cord-306414-2dv3qced	95	15	large	large	JJ
cord-306414-2dv3qced	95	16	doublestranded	doublestranded	JJ
cord-306414-2dv3qced	95	17	DNA	dna	NN
cord-306414-2dv3qced	95	18	genome	genome	NN
cord-306414-2dv3qced	95	19	that	that	WDT
cord-306414-2dv3qced	95	20	belongs	belong	VBZ
cord-306414-2dv3qced	95	21	to	to	IN
cord-306414-2dv3qced	95	22	the	the	DT
cord-306414-2dv3qced	95	23	γ	γ	NN
cord-306414-2dv3qced	95	24	-	-	HYPH
cord-306414-2dv3qced	95	25	herpesviridae	herpesviridae	NN
cord-306414-2dv3qced	95	26	subfamily	subfamily	NN
cord-306414-2dv3qced	95	27	.	.	.
cord-306414-2dv3qced	96	1	EBV	EBV	NNP
cord-306414-2dv3qced	96	2	was	be	VBD
cord-306414-2dv3qced	96	3	the	the	DT
cord-306414-2dv3qced	96	4	first	first	JJ
cord-306414-2dv3qced	96	5	tumor	tumor	NN
cord-306414-2dv3qced	96	6	virus	virus	NN
cord-306414-2dv3qced	96	7	identified	identify	VBN
cord-306414-2dv3qced	96	8	in	in	IN
cord-306414-2dv3qced	96	9	humans	human	NNS
cord-306414-2dv3qced	96	10	.	.	.
cord-306414-2dv3qced	97	1	The	the	DT
cord-306414-2dv3qced	97	2	virus	virus	NN
cord-306414-2dv3qced	97	3	is	be	VBZ
cord-306414-2dv3qced	97	4	primarily	primarily	RB
cord-306414-2dv3qced	97	5	associated	associate	VBN
cord-306414-2dv3qced	97	6	with	with	IN
cord-306414-2dv3qced	97	7	lymphomas	lymphoma	NNS
cord-306414-2dv3qced	97	8	and	and	CC
cord-306414-2dv3qced	97	9	epithelial	epithelial	JJ
cord-306414-2dv3qced	97	10	cell	cell	NN
cord-306414-2dv3qced	97	11	cancers	cancer	NNS
cord-306414-2dv3qced	97	12	and	and	CC
cord-306414-2dv3qced	97	13	is	be	VBZ
cord-306414-2dv3qced	97	14	the	the	DT
cord-306414-2dv3qced	97	15	causative	causative	JJ
cord-306414-2dv3qced	97	16	agent	agent	NN
cord-306414-2dv3qced	97	17	of	of	IN
cord-306414-2dv3qced	97	18	mononucleosis	mononucleosis	NN
cord-306414-2dv3qced	97	19	after	after	IN
cord-306414-2dv3qced	97	20	infection	infection	NN
cord-306414-2dv3qced	97	21	.	.	.
cord-306414-2dv3qced	98	1	High	high	JJ
cord-306414-2dv3qced	98	2	-	-	HYPH
cord-306414-2dv3qced	98	3	throughput	throughput	NN
cord-306414-2dv3qced	98	4	sequencing	sequencing	NN
cord-306414-2dv3qced	98	5	:	:	:
cord-306414-2dv3qced	98	6	technology	technology	NN
cord-306414-2dv3qced	98	7	capable	capable	JJ
cord-306414-2dv3qced	98	8	of	of	IN
cord-306414-2dv3qced	98	9	sequencing	sequence	VBG
cord-306414-2dv3qced	98	10	multiple	multiple	JJ
cord-306414-2dv3qced	98	11	DNA	dna	NN
cord-306414-2dv3qced	98	12	molecules	molecule	NNS
cord-306414-2dv3qced	98	13	in	in	IN
cord-306414-2dv3qced	98	14	parallel	parallel	NN
cord-306414-2dv3qced	98	15	to	to	TO
cord-306414-2dv3qced	98	16	enable	enable	VB
cord-306414-2dv3qced	98	17	millions	million	NNS
cord-306414-2dv3qced	98	18	of	of	IN
cord-306414-2dv3qced	98	19	DNA	dna	NN
cord-306414-2dv3qced	98	20	molecules	molecule	NNS
cord-306414-2dv3qced	98	21	to	to	TO
cord-306414-2dv3qced	98	22	be	be	VB
cord-306414-2dv3qced	98	23	sequenced	sequence	VBN
cord-306414-2dv3qced	98	24	at	at	IN
cord-306414-2dv3qced	98	25	once	once	RB
cord-306414-2dv3qced	98	26	.	.	.
cord-306414-2dv3qced	99	1	This	this	DT
cord-306414-2dv3qced	99	2	is	be	VBZ
cord-306414-2dv3qced	99	3	much	much	RB
cord-306414-2dv3qced	99	4	quicker	quick	JJR
cord-306414-2dv3qced	99	5	and	and	CC
cord-306414-2dv3qced	99	6	cheaper	cheap	JJR
cord-306414-2dv3qced	99	7	than	than	IN
cord-306414-2dv3qced	99	8	the	the	DT
cord-306414-2dv3qced	99	9	previously	previously	RB
cord-306414-2dv3qced	99	10	used	use	VBN
cord-306414-2dv3qced	99	11	Sanger	Sanger	NNP
cord-306414-2dv3qced	99	12	sequencing	sequencing	NN
cord-306414-2dv3qced	99	13	and	and	CC
cord-306414-2dv3qced	99	14	,	,	,
cord-306414-2dv3qced	99	15	as	as	IN
cord-306414-2dv3qced	99	16	such	such	JJ
cord-306414-2dv3qced	99	17	,	,	,
cord-306414-2dv3qced	99	18	revolutionized	revolutionize	VBD
cord-306414-2dv3qced	99	19	the	the	DT
cord-306414-2dv3qced	99	20	study	study	NN
cord-306414-2dv3qced	99	21	of	of	IN
cord-306414-2dv3qced	99	22	genomics	genomic	NNS
cord-306414-2dv3qced	99	23	and	and	CC
cord-306414-2dv3qced	99	24	molecular	molecular	JJ
cord-306414-2dv3qced	99	25	biology	biology	NN
cord-306414-2dv3qced	99	26	.	.	.
cord-306414-2dv3qced	100	1	Human	human	JJ
cord-306414-2dv3qced	100	2	leukocyte	leukocyte	NN
cord-306414-2dv3qced	100	3	antigen	antigen	NN
cord-306414-2dv3qced	100	4	(	(	-LRB-
cord-306414-2dv3qced	100	5	HLA	HLA	NNP
cord-306414-2dv3qced	100	6	)	)	-RRB-
cord-306414-2dv3qced	100	7	:	:	:
cord-306414-2dv3qced	100	8	gene	gene	NN
cord-306414-2dv3qced	100	9	cluster	cluster	NN
cord-306414-2dv3qced	100	10	that	that	WDT
cord-306414-2dv3qced	100	11	encodes	encode	VBZ
cord-306414-2dv3qced	100	12	the	the	DT
cord-306414-2dv3qced	100	13	major	major	JJ
cord-306414-2dv3qced	100	14	histocompatibility	histocompatibility	NN
cord-306414-2dv3qced	100	15	complex	complex	NN
cord-306414-2dv3qced	100	16	proteins	protein	NNS
cord-306414-2dv3qced	100	17	,	,	,
cord-306414-2dv3qced	100	18	which	which	WDT
cord-306414-2dv3qced	100	19	present	present	VBP
cord-306414-2dv3qced	100	20	antigen	antigen	NN
cord-306414-2dv3qced	100	21	peptides	peptide	NNS
cord-306414-2dv3qced	100	22	to	to	IN
cord-306414-2dv3qced	100	23	the	the	DT
cord-306414-2dv3qced	100	24	host	host	NN
cord-306414-2dv3qced	100	25	immune	immune	JJ
cord-306414-2dv3qced	100	26	system	system	NN
cord-306414-2dv3qced	100	27	.	.	.
cord-306414-2dv3qced	101	1	These	these	DT
cord-306414-2dv3qced	101	2	are	be	VBP
cord-306414-2dv3qced	101	3	among	among	IN
cord-306414-2dv3qced	101	4	the	the	DT
cord-306414-2dv3qced	101	5	most	most	RBS
cord-306414-2dv3qced	101	6	polymorphic	polymorphic	JJ
cord-306414-2dv3qced	101	7	genes	gene	NNS
cord-306414-2dv3qced	101	8	in	in	IN
cord-306414-2dv3qced	101	9	the	the	DT
cord-306414-2dv3qced	101	10	human	human	JJ
cord-306414-2dv3qced	101	11	genome	genome	NN
cord-306414-2dv3qced	101	12	.	.	.
cord-306414-2dv3qced	102	1	Influenza	influenza	NN
cord-306414-2dv3qced	102	2	:	:	:
cord-306414-2dv3qced	102	3	a	a	DT
cord-306414-2dv3qced	102	4	virus	virus	NN
cord-306414-2dv3qced	102	5	commonly	commonly	RB
cord-306414-2dv3qced	102	6	known	know	VBN
cord-306414-2dv3qced	102	7	as	as	IN
cord-306414-2dv3qced	102	8	the	the	DT
cord-306414-2dv3qced	102	9	'	'	``
cord-306414-2dv3qced	102	10	flu	flu	NN
cord-306414-2dv3qced	102	11	'	'	''
cord-306414-2dv3qced	102	12	that	that	WDT
cord-306414-2dv3qced	102	13	attacks	attack	VBZ
cord-306414-2dv3qced	102	14	the	the	DT
cord-306414-2dv3qced	102	15	respiratory	respiratory	JJ
cord-306414-2dv3qced	102	16	system	system	NN
cord-306414-2dv3qced	102	17	.	.	.
cord-306414-2dv3qced	103	1	Influenza	influenza	NN
cord-306414-2dv3qced	103	2	viruses	virus	NNS
cord-306414-2dv3qced	103	3	are	be	VBP
cord-306414-2dv3qced	103	4	members	member	NNS
cord-306414-2dv3qced	103	5	of	of	IN
cord-306414-2dv3qced	103	6	the	the	DT
cord-306414-2dv3qced	103	7	family	family	NN
cord-306414-2dv3qced	103	8	Orthomyxoviridae	Orthomyxoviridae	NNP
cord-306414-2dv3qced	103	9	.	.	.
cord-306414-2dv3qced	104	1	This	this	DT
cord-306414-2dv3qced	104	2	family	family	NN
cord-306414-2dv3qced	104	3	represents	represent	VBZ
cord-306414-2dv3qced	104	4	enveloped	envelop	VBN
cord-306414-2dv3qced	104	5	viruses	virus	NNS
cord-306414-2dv3qced	104	6	,	,	,
cord-306414-2dv3qced	104	7	the	the	DT
cord-306414-2dv3qced	104	8	genome	genome	NN
cord-306414-2dv3qced	104	9	of	of	IN
cord-306414-2dv3qced	104	10	which	which	WDT
cord-306414-2dv3qced	104	11	consists	consist	VBZ
cord-306414-2dv3qced	104	12	of	of	IN
cord-306414-2dv3qced	104	13	segmented	segmented	JJ
cord-306414-2dv3qced	104	14	negative	negative	JJ
cord-306414-2dv3qced	104	15	-	-	HYPH
cord-306414-2dv3qced	104	16	sense	sense	NN
cord-306414-2dv3qced	104	17	singlestrand	singlestrand	NN
cord-306414-2dv3qced	104	18	RNA	RNA	NNP
cord-306414-2dv3qced	104	19	segments	segment	NNS
cord-306414-2dv3qced	104	20	.	.	.
cord-306414-2dv3qced	105	1	There	there	EX
cord-306414-2dv3qced	105	2	are	be	VBP
cord-306414-2dv3qced	105	3	four	four	CD
cord-306414-2dv3qced	105	4	genera	genus	NNS
cord-306414-2dv3qced	105	5	of	of	IN
cord-306414-2dv3qced	105	6	this	this	DT
cord-306414-2dv3qced	105	7	family	family	NN
cord-306414-2dv3qced	105	8	:	:	:
cord-306414-2dv3qced	105	9	types	type	NNS
cord-306414-2dv3qced	105	10	A	A	NNP
cord-306414-2dv3qced	105	11	,	,	,
cord-306414-2dv3qced	105	12	B	b	NN
cord-306414-2dv3qced	105	13	,	,	,
cord-306414-2dv3qced	105	14	C	C	NNP
cord-306414-2dv3qced	105	15	,	,	,
cord-306414-2dv3qced	105	16	and	and	CC
cord-306414-2dv3qced	105	17	Thogotovirus	Thogotovirus	NNP
cord-306414-2dv3qced	105	18	,	,	,
cord-306414-2dv3qced	105	19	of	of	IN
cord-306414-2dv3qced	105	20	which	which	WDT
cord-306414-2dv3qced	105	21	,	,	,
cord-306414-2dv3qced	105	22	however	however	RB
cord-306414-2dv3qced	105	23	,	,	,
cord-306414-2dv3qced	105	24	only	only	RB
cord-306414-2dv3qced	105	25	genera	genus	NNS
cord-306414-2dv3qced	105	26	A	a	NN
cord-306414-2dv3qced	105	27	and	and	CC
cord-306414-2dv3qced	105	28	B	b	NN
cord-306414-2dv3qced	105	29	are	be	VBP
cord-306414-2dv3qced	105	30	clinically	clinically	RB
cord-306414-2dv3qced	105	31	relevant	relevant	JJ
cord-306414-2dv3qced	105	32	for	for	IN
cord-306414-2dv3qced	105	33	humans	human	NNS
cord-306414-2dv3qced	105	34	.	.	.
cord-306414-2dv3qced	106	1	Innate	innate	JJ
cord-306414-2dv3qced	106	2	immunity	immunity	NN
cord-306414-2dv3qced	106	3	:	:	:
cord-306414-2dv3qced	106	4	an	an	DT
cord-306414-2dv3qced	106	5	immunological	immunological	JJ
cord-306414-2dv3qced	106	6	subsystem	subsystem	NN
cord-306414-2dv3qced	106	7	that	that	WDT
cord-306414-2dv3qced	106	8	comprises	comprise	VBZ
cord-306414-2dv3qced	106	9	the	the	DT
cord-306414-2dv3qced	106	10	cells	cell	NNS
cord-306414-2dv3qced	106	11	and	and	CC
cord-306414-2dv3qced	106	12	mechanisms	mechanism	NNS
cord-306414-2dv3qced	106	13	that	that	WDT
cord-306414-2dv3qced	106	14	provide	provide	VBP
cord-306414-2dv3qced	106	15	the	the	DT
cord-306414-2dv3qced	106	16	first	first	JJ
cord-306414-2dv3qced	106	17	line	line	NN
cord-306414-2dv3qced	106	18	of	of	IN
cord-306414-2dv3qced	106	19	defense	defense	NN
cord-306414-2dv3qced	106	20	from	from	IN
cord-306414-2dv3qced	106	21	infection	infection	NN
cord-306414-2dv3qced	106	22	in	in	IN
cord-306414-2dv3qced	106	23	a	a	DT
cord-306414-2dv3qced	106	24	nonspecific	nonspecific	JJ
cord-306414-2dv3qced	106	25	manner	manner	NN
cord-306414-2dv3qced	106	26	.	.	.
cord-306414-2dv3qced	107	1	It	-PRON-	PRP
cord-306414-2dv3qced	107	2	detects	detect	VBZ
cord-306414-2dv3qced	107	3	and	and	CC
cord-306414-2dv3qced	107	4	responds	respond	VBZ
cord-306414-2dv3qced	107	5	to	to	IN
cord-306414-2dv3qced	107	6	pathogen	pathogen	NN
cord-306414-2dv3qced	107	7	associated	associate	VBD
cord-306414-2dv3qced	107	8	molecular	molecular	JJ
cord-306414-2dv3qced	107	9	patterns	pattern	NNS
cord-306414-2dv3qced	107	10	(	(	-LRB-
cord-306414-2dv3qced	107	11	PAMPS	PAMPS	NNP
cord-306414-2dv3qced	107	12	)	)	-RRB-
cord-306414-2dv3qced	107	13	that	that	WDT
cord-306414-2dv3qced	107	14	are	be	VBP
cord-306414-2dv3qced	107	15	not	not	RB
cord-306414-2dv3qced	107	16	naturally	naturally	RB
cord-306414-2dv3qced	107	17	occurring	occur	VBG
cord-306414-2dv3qced	107	18	within	within	IN
cord-306414-2dv3qced	107	19	the	the	DT
cord-306414-2dv3qced	107	20	entire	entire	JJ
cord-306414-2dv3qced	107	21	organism	organism	NN
cord-306414-2dv3qced	107	22	.	.	.
cord-306414-2dv3qced	108	1	Interferon	interferon	NN
cord-306414-2dv3qced	108	2	-	-	HYPH
cord-306414-2dv3qced	108	3	γ	γ	NNP
cord-306414-2dv3qced	108	4	(	(	-LRB-
cord-306414-2dv3qced	108	5	IFN	IFN	NNP
cord-306414-2dv3qced	108	6	-	-	HYPH
cord-306414-2dv3qced	108	7	γ	γ	NNP
cord-306414-2dv3qced	108	8	)	)	-RRB-
cord-306414-2dv3qced	108	9	:	:	:
cord-306414-2dv3qced	108	10	cytokine	cytokine	NN
cord-306414-2dv3qced	108	11	that	that	WDT
cord-306414-2dv3qced	108	12	has	have	VBZ
cord-306414-2dv3qced	108	13	since	since	IN
cord-306414-2dv3qced	108	14	been	be	VBN
cord-306414-2dv3qced	108	15	characterized	characterize	VBN
cord-306414-2dv3qced	108	16	as	as	IN
cord-306414-2dv3qced	108	17	a	a	DT
cord-306414-2dv3qced	108	18	homodimeric	homodimeric	NNP
cord-306414-2dv3qced	108	19	glycoprotein	glycoprotein	NN
cord-306414-2dv3qced	108	20	with	with	IN
cord-306414-2dv3qced	108	21	pleiotropic	pleiotropic	JJ
cord-306414-2dv3qced	108	22	immunologic	immunologic	JJ
cord-306414-2dv3qced	108	23	functions	function	NNS
cord-306414-2dv3qced	108	24	.	.	.
cord-306414-2dv3qced	109	1	IFN	IFN	NNP
cord-306414-2dv3qced	109	2	-	-	HYPH
cord-306414-2dv3qced	109	3	γ	γ	NNP
cord-306414-2dv3qced	109	4	is	be	VBZ
cord-306414-2dv3qced	109	5	primarily	primarily	RB
cord-306414-2dv3qced	109	6	secreted	secrete	VBN
cord-306414-2dv3qced	109	7	by	by	IN
cord-306414-2dv3qced	109	8	activated	activate	VBN
cord-306414-2dv3qced	109	9	T	T	NNP
cord-306414-2dv3qced	109	10	cells	cell	NNS
cord-306414-2dv3qced	109	11	and	and	CC
cord-306414-2dv3qced	109	12	natural	natural	JJ
cord-306414-2dv3qced	109	13	killer	killer	NN
cord-306414-2dv3qced	109	14	cells	cell	NNS
cord-306414-2dv3qced	109	15	and	and	CC
cord-306414-2dv3qced	109	16	can	can	MD
cord-306414-2dv3qced	109	17	promote	promote	VB
cord-306414-2dv3qced	109	18	macrophage	macrophage	NN
cord-306414-2dv3qced	109	19	activation	activation	NN
cord-306414-2dv3qced	109	20	,	,	,
cord-306414-2dv3qced	109	21	mediate	mediate	VB
cord-306414-2dv3qced	109	22	antiviral	antiviral	JJ
cord-306414-2dv3qced	109	23	and	and	CC
cord-306414-2dv3qced	109	24	antibacterial	antibacterial	JJ
cord-306414-2dv3qced	109	25	immunity	immunity	NN
cord-306414-2dv3qced	109	26	,	,	,
cord-306414-2dv3qced	109	27	enhance	enhance	VB
cord-306414-2dv3qced	109	28	antigen	antigen	NN
cord-306414-2dv3qced	109	29	presentation	presentation	NN
cord-306414-2dv3qced	109	30	,	,	,
cord-306414-2dv3qced	109	31	orchestrate	orchestrate	VB
cord-306414-2dv3qced	109	32	activation	activation	NN
cord-306414-2dv3qced	109	33	of	of	IN
cord-306414-2dv3qced	109	34	the	the	DT
cord-306414-2dv3qced	109	35	innate	innate	JJ
cord-306414-2dv3qced	109	36	immune	immune	JJ
cord-306414-2dv3qced	109	37	system	system	NN
cord-306414-2dv3qced	109	38	,	,	,
cord-306414-2dv3qced	109	39	coordinate	coordinate	VB
cord-306414-2dv3qced	109	40	lymphocyte	lymphocyte	NN
cord-306414-2dv3qced	109	41	-	-	HYPH
cord-306414-2dv3qced	109	42	endothelium	endothelium	NN
cord-306414-2dv3qced	109	43	highly	highly	RB
cord-306414-2dv3qced	109	44	conserved	conserve	VBN
cord-306414-2dv3qced	109	45	SARS	SARS	NNP
cord-306414-2dv3qced	109	46	-	-	HYPH
cord-306414-2dv3qced	109	47	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	109	48	peptides	peptide	NNS
cord-306414-2dv3qced	109	49	that	that	WDT
cord-306414-2dv3qced	109	50	are	be	VBP
cord-306414-2dv3qced	109	51	shared	share	VBN
cord-306414-2dv3qced	109	52	among	among	IN
cord-306414-2dv3qced	109	53	common	common	JJ
cord-306414-2dv3qced	109	54	human	human	JJ
cord-306414-2dv3qced	109	55	coronaviruses	coronaviruse	NNS
cord-306414-2dv3qced	109	56	,	,	,
cord-306414-2dv3qced	109	57	suggesting	suggest	VBG
cord-306414-2dv3qced	109	58	a	a	DT
cord-306414-2dv3qced	109	59	potential	potential	JJ
cord-306414-2dv3qced	109	60	cross	cross	JJ
cord-306414-2dv3qced	109	61	-	-	JJ
cord-306414-2dv3qced	109	62	protective	protective	JJ
cord-306414-2dv3qced	109	63	T	t	NN
cord-306414-2dv3qced	109	64	cell	cell	NN
cord-306414-2dv3qced	109	65	immunity	immunity	NN
cord-306414-2dv3qced	109	66	[	[	-LRB-
cord-306414-2dv3qced	109	67	48	48	CD
cord-306414-2dv3qced	109	68	]	]	-RRB-
cord-306414-2dv3qced	109	69	.	.	.
cord-306414-2dv3qced	110	1	These	these	DT
cord-306414-2dv3qced	110	2	observations	observation	NNS
cord-306414-2dv3qced	110	3	raise	raise	VBP
cord-306414-2dv3qced	110	4	the	the	DT
cord-306414-2dv3qced	110	5	important	important	JJ
cord-306414-2dv3qced	110	6	question	question	NN
cord-306414-2dv3qced	110	7	of	of	IN
cord-306414-2dv3qced	110	8	which	which	WDT
cord-306414-2dv3qced	110	9	alleles	allele	NNS
cord-306414-2dv3qced	110	10	confer	confer	VBP
cord-306414-2dv3qced	110	11	susceptibility	susceptibility	NN
cord-306414-2dv3qced	110	12	or	or	CC
cord-306414-2dv3qced	110	13	resistance	resistance	NN
cord-306414-2dv3qced	110	14	to	to	IN
cord-306414-2dv3qced	110	15	the	the	DT
cord-306414-2dv3qced	110	16	SARS	SARS	NNP
cord-306414-2dv3qced	110	17	-	-	HYPH
cord-306414-2dv3qced	110	18	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	110	19	infection	infection	NN
cord-306414-2dv3qced	110	20	.	.	.
cord-306414-2dv3qced	111	1	Unraveling	unravel	VBG
cord-306414-2dv3qced	111	2	the	the	DT
cord-306414-2dv3qced	111	3	TCR	TCR	NNP
cord-306414-2dv3qced	111	4	Repertoire	repertoire	NN
cord-306414-2dv3qced	111	5	to	to	TO
cord-306414-2dv3qced	111	6	Decode	decode	VB
cord-306414-2dv3qced	111	7	the	the	DT
cord-306414-2dv3qced	111	8	Dynamic	Dynamic	NNP
cord-306414-2dv3qced	111	9	of	of	IN
cord-306414-2dv3qced	111	10	SARS	SARS	NNP
cord-306414-2dv3qced	111	11	-	-	HYPH
cord-306414-2dv3qced	111	12	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	111	13	Immune	Immune	NNP
cord-306414-2dv3qced	111	14	Response	response	NN
cord-306414-2dv3qced	112	1	A	a	DT
cord-306414-2dv3qced	112	2	protective	protective	JJ
cord-306414-2dv3qced	112	3	T	t	NN
cord-306414-2dv3qced	112	4	cell	cell	NN
cord-306414-2dv3qced	112	5	-	-	HYPH
cord-306414-2dv3qced	112	6	driven	drive	VBN
cord-306414-2dv3qced	112	7	immune	immune	JJ
cord-306414-2dv3qced	112	8	response	response	NN
cord-306414-2dv3qced	112	9	to	to	IN
cord-306414-2dv3qced	112	10	unpredicted	unpredicted	JJ
cord-306414-2dv3qced	112	11	antigens	antigen	NNS
cord-306414-2dv3qced	112	12	requires	require	VBZ
cord-306414-2dv3qced	112	13	the	the	DT
cord-306414-2dv3qced	112	14	immune	immune	JJ
cord-306414-2dv3qced	112	15	system	system	NN
cord-306414-2dv3qced	112	16	to	to	TO
cord-306414-2dv3qced	112	17	generate	generate	VB
cord-306414-2dv3qced	112	18	a	a	DT
cord-306414-2dv3qced	112	19	diverse	diverse	JJ
cord-306414-2dv3qced	112	20	TCR	TCR	NNP
cord-306414-2dv3qced	112	21	repertoire	repertoire	NN
cord-306414-2dv3qced	112	22	that	that	WDT
cord-306414-2dv3qced	112	23	is	be	VBZ
cord-306414-2dv3qced	112	24	ready	ready	JJ
cord-306414-2dv3qced	112	25	for	for	IN
cord-306414-2dv3qced	112	26	any	any	DT
cord-306414-2dv3qced	112	27	novel	novel	JJ
cord-306414-2dv3qced	112	28	pathogen	pathogen	NN
cord-306414-2dv3qced	112	29	/	/	SYM
cord-306414-2dv3qced	112	30	antigen	antigen	NN
cord-306414-2dv3qced	112	31	challenge	challenge	NN
cord-306414-2dv3qced	112	32	,	,	,
cord-306414-2dv3qced	112	33	such	such	JJ
cord-306414-2dv3qced	112	34	as	as	IN
cord-306414-2dv3qced	112	35	SARS	SARS	NNP
cord-306414-2dv3qced	112	36	-	-	HYPH
cord-306414-2dv3qced	112	37	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	112	38	.	.	.
cord-306414-2dv3qced	113	1	Therefore	therefore	RB
cord-306414-2dv3qced	113	2	,	,	,
cord-306414-2dv3qced	113	3	the	the	DT
cord-306414-2dv3qced	113	4	size	size	NN
cord-306414-2dv3qced	113	5	and	and	CC
cord-306414-2dv3qced	113	6	the	the	DT
cord-306414-2dv3qced	113	7	diversity	diversity	NN
cord-306414-2dv3qced	113	8	of	of	IN
cord-306414-2dv3qced	113	9	the	the	DT
cord-306414-2dv3qced	113	10	TCR	TCR	NNP
cord-306414-2dv3qced	113	11	repertoire	repertoire	NN
cord-306414-2dv3qced	113	12	are	be	VBP
cord-306414-2dv3qced	113	13	major	major	JJ
cord-306414-2dv3qced	113	14	determinants	determinant	NNS
cord-306414-2dv3qced	113	15	of	of	IN
cord-306414-2dv3qced	113	16	the	the	DT
cord-306414-2dv3qced	113	17	immune	immune	JJ
cord-306414-2dv3qced	113	18	response	response	NN
cord-306414-2dv3qced	113	19	to	to	IN
cord-306414-2dv3qced	113	20	a	a	DT
cord-306414-2dv3qced	113	21	given	give	VBN
cord-306414-2dv3qced	113	22	antigen	antigen	NN
cord-306414-2dv3qced	113	23	[	[	-LRB-
cord-306414-2dv3qced	113	24	50	50	CD
cord-306414-2dv3qced	113	25	]	]	-RRB-
cord-306414-2dv3qced	113	26	.	.	.
cord-306414-2dv3qced	114	1	The	the	DT
cord-306414-2dv3qced	114	2	TCR	TCR	NNP
cord-306414-2dv3qced	114	3	repertoire	repertoire	NN
cord-306414-2dv3qced	114	4	can	can	MD
cord-306414-2dv3qced	114	5	be	be	VB
cord-306414-2dv3qced	114	6	further	further	RB
cord-306414-2dv3qced	114	7	divided	divide	VBN
cord-306414-2dv3qced	114	8	into	into	IN
cord-306414-2dv3qced	114	9	naive	naive	JJ
cord-306414-2dv3qced	114	10	and	and	CC
cord-306414-2dv3qced	114	11	memory	memory	NN
cord-306414-2dv3qced	114	12	.	.	.
cord-306414-2dv3qced	115	1	The	the	DT
cord-306414-2dv3qced	115	2	naive	naive	JJ
cord-306414-2dv3qced	115	3	TCR	TCR	NNP
cord-306414-2dv3qced	115	4	repertoire	repertoire	NN
cord-306414-2dv3qced	115	5	represents	represent	VBZ
cord-306414-2dv3qced	115	6	the	the	DT
cord-306414-2dv3qced	115	7	repertoire	repertoire	NN
cord-306414-2dv3qced	115	8	of	of	IN
cord-306414-2dv3qced	115	9	antigeninexperienced	antigeninexperienced	JJ
cord-306414-2dv3qced	115	10	T	T	NNP
cord-306414-2dv3qced	115	11	cells	cell	NNS
cord-306414-2dv3qced	115	12	.	.	.
cord-306414-2dv3qced	116	1	This	this	DT
cord-306414-2dv3qced	116	2	population	population	NN
cord-306414-2dv3qced	116	3	is	be	VBZ
cord-306414-2dv3qced	116	4	shaped	shape	VBN
cord-306414-2dv3qced	116	5	by	by	IN
cord-306414-2dv3qced	116	6	thymopoiesis	thymopoiesis	NNP
cord-306414-2dv3qced	116	7	,	,	,
cord-306414-2dv3qced	116	8	which	which	WDT
cord-306414-2dv3qced	116	9	introduces	introduce	VBZ
cord-306414-2dv3qced	116	10	new	new	JJ
cord-306414-2dv3qced	116	11	T	T	NNP
cord-306414-2dv3qced	116	12	cell	cell	NN
cord-306414-2dv3qced	116	13	clones	clone	NNS
cord-306414-2dv3qced	116	14	and	and	CC
cord-306414-2dv3qced	116	15	,	,	,
cord-306414-2dv3qced	116	16	therefore	therefore	RB
cord-306414-2dv3qced	116	17	,	,	,
cord-306414-2dv3qced	116	18	new	new	JJ
cord-306414-2dv3qced	116	19	antigen	antigen	NN
cord-306414-2dv3qced	116	20	specificities	specificity	NNS
cord-306414-2dv3qced	116	21	,	,	,
cord-306414-2dv3qced	116	22	to	to	TO
cord-306414-2dv3qced	116	23	diversify	diversify	VB
cord-306414-2dv3qced	116	24	the	the	DT
cord-306414-2dv3qced	116	25	TCR	TCR	NNP
cord-306414-2dv3qced	116	26	repertoire	repertoire	NN
cord-306414-2dv3qced	116	27	[	[	-LRB-
cord-306414-2dv3qced	116	28	51	51	CD
cord-306414-2dv3qced	116	29	]	]	-RRB-
cord-306414-2dv3qced	116	30	.	.	.
cord-306414-2dv3qced	117	1	Thymopoiesis	Thymopoiesis	NNP
cord-306414-2dv3qced	117	2	can	can	MD
cord-306414-2dv3qced	117	3	generate	generate	VB
cord-306414-2dv3qced	117	4	SAR	SAR	NNP
cord-306414-2dv3qced	117	5	-	-	HYPH
cord-306414-2dv3qced	117	6	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	117	7	reactive	reactive	JJ
cord-306414-2dv3qced	117	8	T	t	NN
cord-306414-2dv3qced	117	9	cells	cell	NNS
cord-306414-2dv3qced	117	10	where	where	WRB
cord-306414-2dv3qced	117	11	they	-PRON-	PRP
cord-306414-2dv3qced	117	12	have	have	VBP
cord-306414-2dv3qced	117	13	not	not	RB
cord-306414-2dv3qced	117	14	existed	exist	VBN
cord-306414-2dv3qced	117	15	previously	previously	RB
cord-306414-2dv3qced	117	16	.	.	.
cord-306414-2dv3qced	118	1	The	the	DT
cord-306414-2dv3qced	118	2	memory	memory	NN
cord-306414-2dv3qced	118	3	TCR	TCR	NNP
cord-306414-2dv3qced	118	4	repertoire	repertoire	NN
cord-306414-2dv3qced	118	5	represents	represent	VBZ
cord-306414-2dv3qced	118	6	the	the	DT
cord-306414-2dv3qced	118	7	repertoire	repertoire	NN
cord-306414-2dv3qced	118	8	of	of	IN
cord-306414-2dv3qced	118	9	antigen	antigen	NN
cord-306414-2dv3qced	118	10	-	-	HYPH
cord-306414-2dv3qced	118	11	experienced	experience	VBN
cord-306414-2dv3qced	118	12	T	T	NNP
cord-306414-2dv3qced	118	13	cells	cell	NNS
cord-306414-2dv3qced	118	14	.	.	.
cord-306414-2dv3qced	119	1	It	-PRON-	PRP
cord-306414-2dv3qced	119	2	is	be	VBZ
cord-306414-2dv3qced	119	3	shaped	shape	VBN
cord-306414-2dv3qced	119	4	by	by	IN
cord-306414-2dv3qced	119	5	an	an	DT
cord-306414-2dv3qced	119	6	individual	individual	NN
cord-306414-2dv3qced	119	7	's	's	POS
cord-306414-2dv3qced	119	8	history	history	NN
cord-306414-2dv3qced	119	9	of	of	IN
cord-306414-2dv3qced	119	10	antigen	antigen	NN
cord-306414-2dv3qced	119	11	exposure	exposure	NN
cord-306414-2dv3qced	119	12	,	,	,
cord-306414-2dv3qced	119	13	whereby	whereby	WRB
cord-306414-2dv3qced	119	14	those	those	DT
cord-306414-2dv3qced	119	15	T	t	NN
cord-306414-2dv3qced	119	16	cells	cell	NNS
cord-306414-2dv3qced	119	17	that	that	WDT
cord-306414-2dv3qced	119	18	have	have	VBP
cord-306414-2dv3qced	119	19	participated	participate	VBN
cord-306414-2dv3qced	119	20	in	in	IN
cord-306414-2dv3qced	119	21	immune	immune	JJ
cord-306414-2dv3qced	119	22	responses	response	NNS
cord-306414-2dv3qced	119	23	persist	persist	VBP
cord-306414-2dv3qced	119	24	long	long	JJ
cord-306414-2dv3qced	119	25	term	term	NN
cord-306414-2dv3qced	119	26	.	.	.
cord-306414-2dv3qced	120	1	Memory	memory	NN
cord-306414-2dv3qced	120	2	T	t	CD
cord-306414-2dv3qced	120	3	cells	cell	NNS
cord-306414-2dv3qced	120	4	,	,	,
cord-306414-2dv3qced	120	5	though	though	IN
cord-306414-2dv3qced	120	6	they	-PRON-	PRP
cord-306414-2dv3qced	120	7	have	have	VBP
cord-306414-2dv3qced	120	8	been	be	VBN
cord-306414-2dv3qced	120	9	selected	select	VBN
cord-306414-2dv3qced	120	10	for	for	IN
cord-306414-2dv3qced	120	11	by	by	IN
cord-306414-2dv3qced	120	12	different	different	JJ
cord-306414-2dv3qced	120	13	antigens	antigen	NNS
cord-306414-2dv3qced	120	14	,	,	,
cord-306414-2dv3qced	120	15	such	such	JJ
cord-306414-2dv3qced	120	16	as	as	IN
cord-306414-2dv3qced	120	17	those	those	DT
cord-306414-2dv3qced	120	18	generated	generate	VBN
cord-306414-2dv3qced	120	19	against	against	IN
cord-306414-2dv3qced	120	20	prior	prior	JJ
cord-306414-2dv3qced	120	21	coronaviruses	coronaviruse	NNS
cord-306414-2dv3qced	120	22	,	,	,
cord-306414-2dv3qced	120	23	may	may	MD
cord-306414-2dv3qced	120	24	still	still	RB
cord-306414-2dv3qced	120	25	generate	generate	VB
cord-306414-2dv3qced	120	26	responses	response	NNS
cord-306414-2dv3qced	120	27	against	against	IN
cord-306414-2dv3qced	120	28	novel	novel	NN
cord-306414-2dv3qced	120	29	viruses	virus	NNS
cord-306414-2dv3qced	120	30	such	such	JJ
cord-306414-2dv3qced	120	31	as	as	IN
cord-306414-2dv3qced	120	32	the	the	DT
cord-306414-2dv3qced	120	33	SARS	SARS	NNP
cord-306414-2dv3qced	120	34	-	-	HYPH
cord-306414-2dv3qced	120	35	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	120	36	[	[	-LRB-
cord-306414-2dv3qced	120	37	52	52	CD
cord-306414-2dv3qced	120	38	]	]	-RRB-
cord-306414-2dv3qced	120	39	.	.	.
cord-306414-2dv3qced	121	1	Indeed	indeed	RB
cord-306414-2dv3qced	121	2	,	,	,
cord-306414-2dv3qced	121	3	a	a	DT
cord-306414-2dv3qced	121	4	recent	recent	JJ
cord-306414-2dv3qced	121	5	study	study	NN
cord-306414-2dv3qced	121	6	reported	report	VBD
cord-306414-2dv3qced	121	7	that	that	IN
cord-306414-2dv3qced	121	8	T	t	NN
cord-306414-2dv3qced	121	9	cell	cell	NN
cord-306414-2dv3qced	121	10	reactivity	reactivity	NN
cord-306414-2dv3qced	121	11	to	to	IN
cord-306414-2dv3qced	121	12	SARS	SARS	NNP
cord-306414-2dv3qced	121	13	-	-	HYPH
cord-306414-2dv3qced	121	14	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	121	15	epitopes	epitope	NNS
cord-306414-2dv3qced	121	16	is	be	VBZ
cord-306414-2dv3qced	121	17	also	also	RB
cord-306414-2dv3qced	121	18	detected	detect	VBN
cord-306414-2dv3qced	121	19	in	in	IN
cord-306414-2dv3qced	121	20	nonexposed	nonexpose	VBN
cord-306414-2dv3qced	121	21	individuals	individual	NNS
cord-306414-2dv3qced	121	22	,	,	,
cord-306414-2dv3qced	121	23	suggesting	suggest	VBG
cord-306414-2dv3qced	121	24	crossreactive	crossreactive	NNP
cord-306414-2dv3qced	121	25	T	T	NNP
cord-306414-2dv3qced	121	26	cell	cell	NN
cord-306414-2dv3qced	121	27	recognition	recognition	NN
cord-306414-2dv3qced	121	28	between	between	IN
cord-306414-2dv3qced	121	29	circulating	circulate	VBG
cord-306414-2dv3qced	121	30	'	'	``
cord-306414-2dv3qced	121	31	common	common	JJ
cord-306414-2dv3qced	121	32	cold	cold	NN
cord-306414-2dv3qced	121	33	'	'	''
cord-306414-2dv3qced	121	34	coronaviruses	coronaviruse	NNS
cord-306414-2dv3qced	121	35	and	and	CC
cord-306414-2dv3qced	121	36	SARS	SARS	NNP
cord-306414-2dv3qced	121	37	-	-	HYPH
cord-306414-2dv3qced	121	38	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	121	39	[	[	-LRB-
cord-306414-2dv3qced	121	40	53	53	CD
cord-306414-2dv3qced	121	41	]	]	-RRB-
cord-306414-2dv3qced	121	42	.	.	.
cord-306414-2dv3qced	122	1	The	the	DT
cord-306414-2dv3qced	122	2	development	development	NN
cord-306414-2dv3qced	122	3	of	of	IN
cord-306414-2dv3qced	122	4	faster	fast	JJR
cord-306414-2dv3qced	122	5	and	and	CC
cord-306414-2dv3qced	122	6	cheaper	cheap	JJR
cord-306414-2dv3qced	122	7	sequencing	sequencing	NN
cord-306414-2dv3qced	122	8	technologies	technology	NNS
cord-306414-2dv3qced	122	9	,	,	,
cord-306414-2dv3qced	122	10	augmented	augment	VBN
cord-306414-2dv3qced	122	11	by	by	IN
cord-306414-2dv3qced	122	12	the	the	DT
cord-306414-2dv3qced	122	13	advances	advance	NNS
cord-306414-2dv3qced	122	14	in	in	IN
cord-306414-2dv3qced	122	15	computational	computational	JJ
cord-306414-2dv3qced	122	16	tools	tool	NNS
cord-306414-2dv3qced	122	17	,	,	,
cord-306414-2dv3qced	122	18	support	support	VB
cord-306414-2dv3qced	122	19	the	the	DT
cord-306414-2dv3qced	122	20	feasibility	feasibility	NN
cord-306414-2dv3qced	122	21	of	of	IN
cord-306414-2dv3qced	122	22	using	use	VBG
cord-306414-2dv3qced	122	23	TCR	TCR	NNP
cord-306414-2dv3qced	122	24	analyses	analysis	NNS
cord-306414-2dv3qced	122	25	not	not	RB
cord-306414-2dv3qced	122	26	only	only	RB
cord-306414-2dv3qced	122	27	to	to	TO
cord-306414-2dv3qced	122	28	track	track	VB
cord-306414-2dv3qced	122	29	SARS	SARS	NNP
cord-306414-2dv3qced	122	30	-	-	HYPH
cord-306414-2dv3qced	122	31	CoV-2specific	CoV-2specific	NNP
cord-306414-2dv3qced	122	32	T	T	NNP
cord-306414-2dv3qced	122	33	cell	cell	NN
cord-306414-2dv3qced	122	34	expansion	expansion	NN
cord-306414-2dv3qced	122	35	post	post	JJ
cord-306414-2dv3qced	122	36	-	-	JJ
cord-306414-2dv3qced	122	37	COVID-19	covid-19	JJ
cord-306414-2dv3qced	122	38	infection	infection	NN
cord-306414-2dv3qced	122	39	or	or	CC
cord-306414-2dv3qced	122	40	in	in	IN
cord-306414-2dv3qced	122	41	the	the	DT
cord-306414-2dv3qced	122	42	course	course	NN
cord-306414-2dv3qced	122	43	of	of	IN
cord-306414-2dv3qced	122	44	treating	treat	VBG
cord-306414-2dv3qced	122	45	patients	patient	NNS
cord-306414-2dv3qced	122	46	with	with	IN
cord-306414-2dv3qced	122	47	COVID-19	COVID-19	NNP
cord-306414-2dv3qced	122	48	,	,	,
cord-306414-2dv3qced	122	49	but	but	CC
cord-306414-2dv3qced	122	50	also	also	RB
cord-306414-2dv3qced	122	51	to	to	TO
cord-306414-2dv3qced	122	52	establish	establish	VB
cord-306414-2dv3qced	122	53	certain	certain	JJ
cord-306414-2dv3qced	122	54	features	feature	NNS
cord-306414-2dv3qced	122	55	of	of	IN
cord-306414-2dv3qced	122	56	the	the	DT
cord-306414-2dv3qced	122	57	TCR	TCR	NNP
cord-306414-2dv3qced	122	58	repertoire	repertoire	NN
cord-306414-2dv3qced	122	59	architecture	architecture	NN
cord-306414-2dv3qced	122	60	as	as	IN
cord-306414-2dv3qced	122	61	predictive	predictive	JJ
cord-306414-2dv3qced	122	62	biomarkers	biomarker	NNS
cord-306414-2dv3qced	122	63	for	for	IN
cord-306414-2dv3qced	122	64	patients	patient	NNS
cord-306414-2dv3qced	122	65	'	'	POS
cord-306414-2dv3qced	122	66	clinical	clinical	JJ
cord-306414-2dv3qced	122	67	outcome	outcome	NN
cord-306414-2dv3qced	122	68	.	.	.
cord-306414-2dv3qced	123	1	A	a	DT
cord-306414-2dv3qced	123	2	recent	recent	JJ
cord-306414-2dv3qced	123	3	study	study	NN
cord-306414-2dv3qced	123	4	demonstrated	demonstrate	VBD
cord-306414-2dv3qced	123	5	the	the	DT
cord-306414-2dv3qced	123	6	feasibility	feasibility	NN
cord-306414-2dv3qced	123	7	and	and	CC
cord-306414-2dv3qced	123	8	value	value	NN
cord-306414-2dv3qced	123	9	of	of	IN
cord-306414-2dv3qced	123	10	these	these	DT
cord-306414-2dv3qced	123	11	analyses	analysis	NNS
cord-306414-2dv3qced	123	12	in	in	IN
cord-306414-2dv3qced	123	13	patients	patient	NNS
cord-306414-2dv3qced	123	14	with	with	IN
cord-306414-2dv3qced	123	15	COVID-19	COVID-19	NNP
cord-306414-2dv3qced	123	16	.	.	.
cord-306414-2dv3qced	124	1	In	in	IN
cord-306414-2dv3qced	124	2	ten	ten	CD
cord-306414-2dv3qced	124	3	patients	patient	NNS
cord-306414-2dv3qced	124	4	with	with	IN
cord-306414-2dv3qced	124	5	either	either	CC
cord-306414-2dv3qced	124	6	early	early	JJ
cord-306414-2dv3qced	124	7	recovery	recovery	NN
cord-306414-2dv3qced	124	8	stage	stage	NN
cord-306414-2dv3qced	124	9	or	or	CC
cord-306414-2dv3qced	124	10	late	late	JJ
cord-306414-2dv3qced	124	11	recovery	recovery	NN
cord-306414-2dv3qced	124	12	stage	stage	NN
cord-306414-2dv3qced	125	1	COVID-19	covid-19	VB
cord-306414-2dv3qced	125	2	and	and	CC
cord-306414-2dv3qced	125	3	five	five	CD
cord-306414-2dv3qced	125	4	healthy	healthy	JJ
cord-306414-2dv3qced	125	5	donors	donor	NNS
cord-306414-2dv3qced	125	6	,	,	,
cord-306414-2dv3qced	125	7	TCR	TCR	NNP
cord-306414-2dv3qced	125	8	-	-	HYPH
cord-306414-2dv3qced	125	9	seq	seq	NNP
cord-306414-2dv3qced	125	10	analysis	analysis	NN
cord-306414-2dv3qced	125	11	showed	show	VBD
cord-306414-2dv3qced	125	12	that	that	IN
cord-306414-2dv3qced	125	13	T	T	NNP
cord-306414-2dv3qced	125	14	cell	cell	NN
cord-306414-2dv3qced	125	15	expansion	expansion	NN
cord-306414-2dv3qced	125	16	was	be	VBD
cord-306414-2dv3qced	125	17	lower	low	JJR
cord-306414-2dv3qced	125	18	in	in	IN
cord-306414-2dv3qced	125	19	the	the	DT
cord-306414-2dv3qced	125	20	early	early	JJ
cord-306414-2dv3qced	125	21	recovery	recovery	NN
cord-306414-2dv3qced	125	22	group	group	NN
cord-306414-2dv3qced	125	23	than	than	IN
cord-306414-2dv3qced	125	24	in	in	IN
cord-306414-2dv3qced	125	25	the	the	DT
cord-306414-2dv3qced	125	26	healthy	healthy	JJ
cord-306414-2dv3qced	125	27	control	control	NN
cord-306414-2dv3qced	125	28	group	group	NN
cord-306414-2dv3qced	125	29	.	.	.
cord-306414-2dv3qced	126	1	Also	also	RB
cord-306414-2dv3qced	126	2	,	,	,
cord-306414-2dv3qced	126	3	the	the	DT
cord-306414-2dv3qced	126	4	naïve	naïve	JJ
cord-306414-2dv3qced	126	5	or	or	CC
cord-306414-2dv3qced	126	6	central	central	JJ
cord-306414-2dv3qced	126	7	memory	memory	NN
cord-306414-2dv3qced	126	8	T	T	NNP
cord-306414-2dv3qced	126	9	cells	cell	NNS
cord-306414-2dv3qced	126	10	showed	show	VBD
cord-306414-2dv3qced	126	11	little	little	JJ
cord-306414-2dv3qced	126	12	clonal	clonal	JJ
cord-306414-2dv3qced	126	13	expansion	expansion	NN
cord-306414-2dv3qced	126	14	,	,	,
cord-306414-2dv3qced	126	15	while	while	IN
cord-306414-2dv3qced	126	16	effector	effector	NN
cord-306414-2dv3qced	126	17	memory	memory	NN
cord-306414-2dv3qced	126	18	T	T	NNP
cord-306414-2dv3qced	126	19	cells	cell	NNS
cord-306414-2dv3qced	126	20	,	,	,
cord-306414-2dv3qced	126	21	terminal	terminal	NN
cord-306414-2dv3qced	126	22	effector	effector	NN
cord-306414-2dv3qced	126	23	CD8	CD8	NNP
cord-306414-2dv3qced	126	24	+	+	CC
cord-306414-2dv3qced	126	25	T	T	NNP
cord-306414-2dv3qced	126	26	cells	cell	NNS
cord-306414-2dv3qced	126	27	,	,	,
cord-306414-2dv3qced	126	28	and	and	CC
cord-306414-2dv3qced	126	29	proliferating	proliferate	VBG
cord-306414-2dv3qced	126	30	T	t	NN
cord-306414-2dv3qced	126	31	cells	cell	NNS
cord-306414-2dv3qced	126	32	showed	show	VBD
cord-306414-2dv3qced	126	33	higher	high	JJR
cord-306414-2dv3qced	126	34	expansion	expansion	NN
cord-306414-2dv3qced	126	35	levels	level	NNS
cord-306414-2dv3qced	126	36	.	.	.
cord-306414-2dv3qced	127	1	The	the	DT
cord-306414-2dv3qced	127	2	study	study	NN
cord-306414-2dv3qced	127	3	found	find	VBD
cord-306414-2dv3qced	127	4	that	that	IN
cord-306414-2dv3qced	127	5	the	the	DT
cord-306414-2dv3qced	127	6	most	most	RBS
cord-306414-2dv3qced	127	7	highly	highly	RB
cord-306414-2dv3qced	127	8	expanded	expand	VBN
cord-306414-2dv3qced	127	9	clone	clone	NN
cord-306414-2dv3qced	127	10	in	in	IN
cord-306414-2dv3qced	127	11	the	the	DT
cord-306414-2dv3qced	127	12	early	early	JJ
cord-306414-2dv3qced	127	13	recovered	recover	VBN
cord-306414-2dv3qced	127	14	group	group	NN
cord-306414-2dv3qced	127	15	was	be	VBD
cord-306414-2dv3qced	127	16	TRAV8	trav8	NN
cord-306414-2dv3qced	127	17	-	-	:
cord-306414-2dv3qced	127	18	6-TRAJ45	6-traj45	CD
cord-306414-2dv3qced	127	19	:	:	:
cord-306414-2dv3qced	128	1	TRAV7	TRAV7	NNP
cord-306414-2dv3qced	128	2	-	-	HYPH
cord-306414-2dv3qced	128	3	8-TRBJ2	8-trbj2	CD
cord-306414-2dv3qced	128	4	-	-	SYM
cord-306414-2dv3qced	128	5	1	1	CD
cord-306414-2dv3qced	128	6	[	[	-LRB-
cord-306414-2dv3qced	128	7	54	54	CD
cord-306414-2dv3qced	128	8	]	]	-RRB-
cord-306414-2dv3qced	128	9	.	.	.
cord-306414-2dv3qced	129	1	Thus	thus	RB
cord-306414-2dv3qced	129	2	,	,	,
cord-306414-2dv3qced	129	3	a	a	DT
cord-306414-2dv3qced	129	4	comprehensive	comprehensive	JJ
cord-306414-2dv3qced	129	5	characterization	characterization	NN
cord-306414-2dv3qced	129	6	of	of	IN
cord-306414-2dv3qced	129	7	the	the	DT
cord-306414-2dv3qced	129	8	dynamics	dynamic	NNS
cord-306414-2dv3qced	129	9	and	and	CC
cord-306414-2dv3qced	129	10	composition	composition	NN
cord-306414-2dv3qced	129	11	of	of	IN
cord-306414-2dv3qced	129	12	the	the	DT
cord-306414-2dv3qced	129	13	TCR	TCR	NNP
cord-306414-2dv3qced	129	14	repertoires	repertoire	NNS
cord-306414-2dv3qced	129	15	to	to	IN
cord-306414-2dv3qced	129	16	SARS	SARS	NNP
cord-306414-2dv3qced	129	17	-	-	HYPH
cord-306414-2dv3qced	129	18	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	129	19	infection	infection	NN
cord-306414-2dv3qced	129	20	can	can	MD
cord-306414-2dv3qced	129	21	largely	largely	RB
cord-306414-2dv3qced	129	22	contribute	contribute	VB
cord-306414-2dv3qced	129	23	to	to	IN
cord-306414-2dv3qced	129	24	the	the	DT
cord-306414-2dv3qced	129	25	evolving	evolve	VBG
cord-306414-2dv3qced	129	26	understanding	understanding	NN
cord-306414-2dv3qced	129	27	of	of	IN
cord-306414-2dv3qced	129	28	the	the	DT
cord-306414-2dv3qced	129	29	functional	functional	JJ
cord-306414-2dv3qced	129	30	and	and	CC
cord-306414-2dv3qced	129	31	mechanistic	mechanistic	JJ
cord-306414-2dv3qced	129	32	involvement	involvement	NN
cord-306414-2dv3qced	129	33	of	of	IN
cord-306414-2dv3qced	129	34	the	the	DT
cord-306414-2dv3qced	129	35	adaptive	adaptive	JJ
cord-306414-2dv3qced	129	36	immune	immune	JJ
cord-306414-2dv3qced	129	37	cell	cell	NN
cord-306414-2dv3qced	129	38	response	response	NN
cord-306414-2dv3qced	129	39	and	and	CC
cord-306414-2dv3qced	129	40	potentially	potentially	RB
cord-306414-2dv3qced	129	41	guide	guide	VB
cord-306414-2dv3qced	129	42	the	the	DT
cord-306414-2dv3qced	129	43	design	design	NN
cord-306414-2dv3qced	129	44	of	of	IN
cord-306414-2dv3qced	129	45	effective	effective	JJ
cord-306414-2dv3qced	129	46	treatment	treatment	NN
cord-306414-2dv3qced	129	47	.	.	.
cord-306414-2dv3qced	130	1	Here	here	RB
cord-306414-2dv3qced	130	2	we	-PRON-	PRP
cord-306414-2dv3qced	130	3	summarize	summarize	VBP
cord-306414-2dv3qced	130	4	some	some	DT
cord-306414-2dv3qced	130	5	of	of	IN
cord-306414-2dv3qced	130	6	the	the	DT
cord-306414-2dv3qced	130	7	most	most	RBS
cord-306414-2dv3qced	130	8	relevant	relevant	JJ
cord-306414-2dv3qced	130	9	clinical	clinical	JJ
cord-306414-2dv3qced	130	10	applications	application	NNS
cord-306414-2dv3qced	130	11	of	of	IN
cord-306414-2dv3qced	130	12	obtaining	obtain	VBG
cord-306414-2dv3qced	130	13	comprehensive	comprehensive	JJ
cord-306414-2dv3qced	130	14	TCR	TCR	NNP
cord-306414-2dv3qced	130	15	repertoire	repertoire	NN
cord-306414-2dv3qced	130	16	data	datum	NNS
cord-306414-2dv3qced	130	17	in	in	IN
cord-306414-2dv3qced	130	18	the	the	DT
cord-306414-2dv3qced	130	19	setting	setting	NN
cord-306414-2dv3qced	130	20	of	of	IN
cord-306414-2dv3qced	130	21	COVID-19	covid-19	NN
cord-306414-2dv3qced	130	22	.	.	.
cord-306414-2dv3qced	131	1	Recent	recent	JJ
cord-306414-2dv3qced	131	2	efforts	effort	NNS
cord-306414-2dv3qced	131	3	have	have	VBP
cord-306414-2dv3qced	131	4	focused	focus	VBN
cord-306414-2dv3qced	131	5	on	on	IN
cord-306414-2dv3qced	131	6	identifying	identify	VBG
cord-306414-2dv3qced	131	7	shared	share	VBN
cord-306414-2dv3qced	131	8	motifs	motif	NNS
cord-306414-2dv3qced	131	9	in	in	IN
cord-306414-2dv3qced	131	10	core	core	NN
cord-306414-2dv3qced	131	11	sequences	sequence	NNS
cord-306414-2dv3qced	131	12	to	to	TO
cord-306414-2dv3qced	131	13	predict	predict	VB
cord-306414-2dv3qced	131	14	conserved	conserved	JJ
cord-306414-2dv3qced	131	15	residues	residue	NNS
cord-306414-2dv3qced	131	16	driving	drive	VBG
cord-306414-2dv3qced	131	17	essential	essential	JJ
cord-306414-2dv3qced	131	18	elements	element	NNS
cord-306414-2dv3qced	131	19	of	of	IN
cord-306414-2dv3qced	131	20	TCR	TCR	NNP
cord-306414-2dv3qced	131	21	recognition	recognition	NNP
cord-306414-2dv3qced	131	22	[	[	-LRB-
cord-306414-2dv3qced	131	23	22	22	CD
cord-306414-2dv3qced	131	24	,	,	,
cord-306414-2dv3qced	131	25	55	55	CD
cord-306414-2dv3qced	131	26	]	]	-RRB-
cord-306414-2dv3qced	131	27	.	.	.
cord-306414-2dv3qced	132	1	As	as	IN
cord-306414-2dv3qced	132	2	with	with	IN
cord-306414-2dv3qced	132	3	any	any	DT
cord-306414-2dv3qced	132	4	other	other	JJ
cord-306414-2dv3qced	132	5	viral	viral	JJ
cord-306414-2dv3qced	132	6	infection	infection	NN
cord-306414-2dv3qced	132	7	,	,	,
cord-306414-2dv3qced	132	8	the	the	DT
cord-306414-2dv3qced	132	9	ability	ability	NN
cord-306414-2dv3qced	132	10	of	of	IN
cord-306414-2dv3qced	132	11	individuals	individual	NNS
cord-306414-2dv3qced	132	12	'	'	POS
cord-306414-2dv3qced	132	13	TCR	TCR	NNP
cord-306414-2dv3qced	132	14	repertoire	repertoire	NN
cord-306414-2dv3qced	132	15	to	to	IN
cord-306414-2dv3qced	133	1	effectively	effectively	RB
cord-306414-2dv3qced	133	2	clear	clear	JJ
cord-306414-2dv3qced	133	3	SARS	SARS	NNP
cord-306414-2dv3qced	133	4	-	-	HYPH
cord-306414-2dv3qced	133	5	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	133	6	infection	infection	NN
cord-306414-2dv3qced	133	7	is	be	VBZ
cord-306414-2dv3qced	133	8	highly	highly	RB
cord-306414-2dv3qced	133	9	dependent	dependent	JJ
cord-306414-2dv3qced	133	10	on	on	IN
cord-306414-2dv3qced	133	11	its	-PRON-	PRP$
cord-306414-2dv3qced	133	12	composition	composition	NN
cord-306414-2dv3qced	133	13	.	.	.
cord-306414-2dv3qced	134	1	Epitope	epitope	NN
cord-306414-2dv3qced	134	2	-	-	HYPH
cord-306414-2dv3qced	134	3	specific	specific	JJ
cord-306414-2dv3qced	134	4	T	t	NN
cord-306414-2dv3qced	134	5	cells	cell	NNS
cord-306414-2dv3qced	134	6	have	have	VBP
cord-306414-2dv3qced	134	7	been	be	VBN
cord-306414-2dv3qced	134	8	identified	identify	VBN
cord-306414-2dv3qced	134	9	in	in	IN
cord-306414-2dv3qced	134	10	a	a	DT
cord-306414-2dv3qced	134	11	study	study	NN
cord-306414-2dv3qced	134	12	using	use	VBG
cord-306414-2dv3qced	134	13	samples	sample	NNS
cord-306414-2dv3qced	134	14	obtained	obtain	VBN
cord-306414-2dv3qced	134	15	from	from	IN
cord-306414-2dv3qced	134	16	individuals	individual	NNS
cord-306414-2dv3qced	134	17	previously	previously	RB
cord-306414-2dv3qced	134	18	infected	infect	VBN
cord-306414-2dv3qced	134	19	with	with	IN
cord-306414-2dv3qced	134	20	SARS	SARS	NNP
cord-306414-2dv3qced	134	21	-	-	HYPH
cord-306414-2dv3qced	134	22	CoV	CoV	NNP
cord-306414-2dv3qced	134	23	[	[	-LRB-
cord-306414-2dv3qced	134	24	56	56	CD
cord-306414-2dv3qced	134	25	]	]	-RRB-
cord-306414-2dv3qced	134	26	.	.	.
cord-306414-2dv3qced	135	1	Similarly	similarly	RB
cord-306414-2dv3qced	135	2	,	,	,
cord-306414-2dv3qced	135	3	another	another	DT
cord-306414-2dv3qced	135	4	study	study	NN
cord-306414-2dv3qced	135	5	demonstrated	demonstrate	VBD
cord-306414-2dv3qced	135	6	the	the	DT
cord-306414-2dv3qced	135	7	presence	presence	NN
cord-306414-2dv3qced	135	8	of	of	IN
cord-306414-2dv3qced	135	9	epitope	epitope	NN
cord-306414-2dv3qced	135	10	-	-	HYPH
cord-306414-2dv3qced	135	11	specific	specific	JJ
cord-306414-2dv3qced	135	12	public	public	JJ
cord-306414-2dv3qced	135	13	T	t	NN
cord-306414-2dv3qced	135	14	cells	cell	NNS
cord-306414-2dv3qced	135	15	in	in	IN
cord-306414-2dv3qced	135	16	both	both	CC
cord-306414-2dv3qced	135	17	healthy	healthy	JJ
cord-306414-2dv3qced	135	18	and	and	CC
cord-306414-2dv3qced	135	19	influenzainfected	influenzainfected	JJ
cord-306414-2dv3qced	135	20	patients	patient	NNS
cord-306414-2dv3qced	135	21	[	[	-LRB-
cord-306414-2dv3qced	135	22	32	32	CD
cord-306414-2dv3qced	135	23	]	]	-RRB-
cord-306414-2dv3qced	135	24	.	.	.
cord-306414-2dv3qced	136	1	These	these	DT
cord-306414-2dv3qced	136	2	studies	study	NNS
cord-306414-2dv3qced	136	3	show	show	VBP
cord-306414-2dv3qced	136	4	a	a	DT
cord-306414-2dv3qced	136	5	correlation	correlation	NN
cord-306414-2dv3qced	136	6	between	between	IN
cord-306414-2dv3qced	136	7	the	the	DT
cord-306414-2dv3qced	136	8	presence	presence	NN
cord-306414-2dv3qced	136	9	of	of	IN
cord-306414-2dv3qced	136	10	specific	specific	JJ
cord-306414-2dv3qced	136	11	T	T	NNP
cord-306414-2dv3qced	136	12	cell	cell	NN
cord-306414-2dv3qced	136	13	clones	clone	NNS
cord-306414-2dv3qced	136	14	and	and	CC
cord-306414-2dv3qced	136	15	antiviral	antiviral	JJ
cord-306414-2dv3qced	136	16	immunity	immunity	NN
cord-306414-2dv3qced	136	17	.	.	.
cord-306414-2dv3qced	137	1	Beyond	beyond	IN
cord-306414-2dv3qced	137	2	identifying	identify	VBG
cord-306414-2dv3qced	137	3	specific	specific	JJ
cord-306414-2dv3qced	137	4	clones	clone	NNS
cord-306414-2dv3qced	137	5	,	,	,
cord-306414-2dv3qced	137	6	TCRβ	tcrβ	NN
cord-306414-2dv3qced	137	7	profiling	profiling	NN
cord-306414-2dv3qced	137	8	has	have	VBZ
cord-306414-2dv3qced	137	9	demonstrated	demonstrate	VBN
cord-306414-2dv3qced	137	10	interaction	interaction	NN
cord-306414-2dv3qced	137	11	,	,	,
cord-306414-2dv3qced	137	12	regulate	regulate	VB
cord-306414-2dv3qced	137	13	Th1	th1	CD
cord-306414-2dv3qced	137	14	/	/	SYM
cord-306414-2dv3qced	137	15	Th2	th2	CD
cord-306414-2dv3qced	137	16	balance	balance	NN
cord-306414-2dv3qced	137	17	,	,	,
cord-306414-2dv3qced	137	18	and	and	CC
cord-306414-2dv3qced	137	19	control	control	VB
cord-306414-2dv3qced	137	20	cellular	cellular	JJ
cord-306414-2dv3qced	137	21	proliferation	proliferation	NN
cord-306414-2dv3qced	137	22	and	and	CC
cord-306414-2dv3qced	137	23	apoptosis	apoptosis	NN
cord-306414-2dv3qced	137	24	.	.	.
cord-306414-2dv3qced	138	1	Memory	Memory	NNP
cord-306414-2dv3qced	138	2	T	t	CD
cord-306414-2dv3qced	138	3	cells	cell	NNS
cord-306414-2dv3qced	138	4	:	:	:
cord-306414-2dv3qced	138	5	a	a	DT
cord-306414-2dv3qced	138	6	CD8	CD8	NNP
cord-306414-2dv3qced	138	7	T	T	NNP
cord-306414-2dv3qced	138	8	cell	cell	NN
cord-306414-2dv3qced	138	9	that	that	WDT
cord-306414-2dv3qced	138	10	has	have	VBZ
cord-306414-2dv3qced	138	11	responded	respond	VBN
cord-306414-2dv3qced	138	12	to	to	IN
cord-306414-2dv3qced	138	13	cognate	cognate	JJ
cord-306414-2dv3qced	138	14	antigen	antigen	NN
cord-306414-2dv3qced	138	15	(	(	-LRB-
cord-306414-2dv3qced	138	16	Ag	Ag	NNP
cord-306414-2dv3qced	138	17	)	)	-RRB-
cord-306414-2dv3qced	138	18	and	and	CC
cord-306414-2dv3qced	138	19	persists	persist	VBZ
cord-306414-2dv3qced	138	20	long	long	JJ
cord-306414-2dv3qced	138	21	-	-	HYPH
cord-306414-2dv3qced	138	22	term	term	NN
cord-306414-2dv3qced	138	23	.	.	.
cord-306414-2dv3qced	139	1	These	these	DT
cord-306414-2dv3qced	139	2	cells	cell	NNS
cord-306414-2dv3qced	139	3	can	can	MD
cord-306414-2dv3qced	139	4	populate	populate	VB
cord-306414-2dv3qced	139	5	peripherally	peripherally	RB
cord-306414-2dv3qced	139	6	and	and	CC
cord-306414-2dv3qced	139	7	are	be	VBP
cord-306414-2dv3qced	139	8	poised	poise	VBN
cord-306414-2dv3qced	139	9	to	to	TO
cord-306414-2dv3qced	139	10	immediately	immediately	RB
cord-306414-2dv3qced	139	11	proliferate	proliferate	VB
cord-306414-2dv3qced	139	12	,	,	,
cord-306414-2dv3qced	139	13	execute	execute	VB
cord-306414-2dv3qced	139	14	cytotoxic	cytotoxic	JJ
cord-306414-2dv3qced	139	15	functions	function	NNS
cord-306414-2dv3qced	139	16	,	,	,
cord-306414-2dv3qced	139	17	and	and	CC
cord-306414-2dv3qced	139	18	secrete	secrete	JJ
cord-306414-2dv3qced	139	19	effector	effector	NN
cord-306414-2dv3qced	139	20	cytokines	cytokine	NNS
cord-306414-2dv3qced	139	21	upon	upon	IN
cord-306414-2dv3qced	139	22	Ag	Ag	NNP
cord-306414-2dv3qced	139	23	re	re	NN
cord-306414-2dv3qced	139	24	-	-	NN
cord-306414-2dv3qced	139	25	encounter	encounter	NN
cord-306414-2dv3qced	139	26	and	and	CC
cord-306414-2dv3qced	139	27	exist	exist	VBP
cord-306414-2dv3qced	139	28	in	in	IN
cord-306414-2dv3qced	139	29	different	different	JJ
cord-306414-2dv3qced	139	30	metabolic	metabolic	JJ
cord-306414-2dv3qced	139	31	,	,	,
cord-306414-2dv3qced	139	32	transcriptional	transcriptional	JJ
cord-306414-2dv3qced	139	33	,	,	,
cord-306414-2dv3qced	139	34	and	and	CC
cord-306414-2dv3qced	139	35	epigenetic	epigenetic	JJ
cord-306414-2dv3qced	139	36	states	state	NNS
cord-306414-2dv3qced	139	37	.	.	.
cord-306414-2dv3qced	140	1	Naïve	naïve	JJ
cord-306414-2dv3qced	140	2	T	T	NNP
cord-306414-2dv3qced	140	3	cell	cell	NN
cord-306414-2dv3qced	140	4	:	:	:
cord-306414-2dv3qced	140	5	a	a	DT
cord-306414-2dv3qced	140	6	T	T	NNP
cord-306414-2dv3qced	140	7	cell	cell	NN
cord-306414-2dv3qced	140	8	pool	pool	NN
cord-306414-2dv3qced	140	9	that	that	WDT
cord-306414-2dv3qced	140	10	is	be	VBZ
cord-306414-2dv3qced	140	11	generally	generally	RB
cord-306414-2dv3qced	140	12	considered	consider	VBN
cord-306414-2dv3qced	140	13	to	to	TO
cord-306414-2dv3qced	140	14	be	be	VB
cord-306414-2dv3qced	140	15	a	a	DT
cord-306414-2dv3qced	140	16	fairly	fairly	RB
cord-306414-2dv3qced	140	17	quiescent	quiescent	JJ
cord-306414-2dv3qced	140	18	,	,	,
cord-306414-2dv3qced	140	19	homogeneous	homogeneous	JJ
cord-306414-2dv3qced	140	20	pool	pool	NN
cord-306414-2dv3qced	140	21	of	of	IN
cord-306414-2dv3qced	140	22	antigen	antigen	NN
cord-306414-2dv3qced	140	23	-	-	HYPH
cord-306414-2dv3qced	140	24	inexperienced	inexperienced	JJ
cord-306414-2dv3qced	140	25	cells	cell	NNS
cord-306414-2dv3qced	140	26	.	.	.
cord-306414-2dv3qced	141	1	In	in	IN
cord-306414-2dv3qced	141	2	response	response	NN
cord-306414-2dv3qced	141	3	to	to	IN
cord-306414-2dv3qced	141	4	encountering	encounter	VBG
cord-306414-2dv3qced	141	5	and	and	CC
cord-306414-2dv3qced	141	6	interacting	interact	VBG
cord-306414-2dv3qced	141	7	with	with	IN
cord-306414-2dv3qced	141	8	cognate	cognate	JJ
cord-306414-2dv3qced	141	9	antigens	antigen	NNS
cord-306414-2dv3qced	141	10	in	in	IN
cord-306414-2dv3qced	141	11	the	the	DT
cord-306414-2dv3qced	141	12	periphery	periphery	NN
cord-306414-2dv3qced	141	13	,	,	,
cord-306414-2dv3qced	141	14	naive	naive	JJ
cord-306414-2dv3qced	141	15	T	t	NN
cord-306414-2dv3qced	141	16	cells	cell	NNS
cord-306414-2dv3qced	141	17	will	will	MD
cord-306414-2dv3qced	141	18	proliferate	proliferate	VB
cord-306414-2dv3qced	141	19	and	and	CC
cord-306414-2dv3qced	141	20	differentiate	differentiate	VB
cord-306414-2dv3qced	141	21	into	into	IN
cord-306414-2dv3qced	141	22	different	different	JJ
cord-306414-2dv3qced	141	23	types	type	NNS
cord-306414-2dv3qced	141	24	of	of	IN
cord-306414-2dv3qced	141	25	effector	effector	NN
cord-306414-2dv3qced	141	26	and	and	CC
cord-306414-2dv3qced	141	27	memory	memory	NN
cord-306414-2dv3qced	141	28	T	t	NN
cord-306414-2dv3qced	141	29	cells	cell	NNS
cord-306414-2dv3qced	141	30	,	,	,
cord-306414-2dv3qced	141	31	which	which	WDT
cord-306414-2dv3qced	141	32	can	can	MD
cord-306414-2dv3qced	141	33	migrate	migrate	VB
cord-306414-2dv3qced	141	34	to	to	IN
cord-306414-2dv3qced	141	35	different	different	JJ
cord-306414-2dv3qced	141	36	tissues	tissue	NNS
cord-306414-2dv3qced	141	37	for	for	IN
cord-306414-2dv3qced	141	38	local	local	JJ
cord-306414-2dv3qced	141	39	antigen	antigen	NN
cord-306414-2dv3qced	141	40	patrol	patrol	NN
cord-306414-2dv3qced	141	41	.	.	.
cord-306414-2dv3qced	142	1	Public	Public	NNP
cord-306414-2dv3qced	142	2	T	T	NNP
cord-306414-2dv3qced	142	3	cells	cell	NNS
cord-306414-2dv3qced	142	4	:	:	:
cord-306414-2dv3qced	142	5	refers	refer	VBZ
cord-306414-2dv3qced	142	6	to	to	IN
cord-306414-2dv3qced	142	7	T	t	NN
cord-306414-2dv3qced	142	8	cells	cell	NNS
cord-306414-2dv3qced	142	9	that	that	WDT
cord-306414-2dv3qced	142	10	carry	carry	VBP
cord-306414-2dv3qced	142	11	TCR	TCR	NNP
cord-306414-2dv3qced	142	12	sequences	sequence	NNS
cord-306414-2dv3qced	142	13	that	that	WDT
cord-306414-2dv3qced	142	14	occur	occur	VBP
cord-306414-2dv3qced	142	15	in	in	IN
cord-306414-2dv3qced	142	16	multiple	multiple	JJ
cord-306414-2dv3qced	142	17	unrelated	unrelated	JJ
cord-306414-2dv3qced	142	18	individuals	individual	NNS
cord-306414-2dv3qced	142	19	,	,	,
cord-306414-2dv3qced	142	20	often	often	RB
cord-306414-2dv3qced	142	21	in	in	IN
cord-306414-2dv3qced	142	22	response	response	NN
cord-306414-2dv3qced	142	23	to	to	IN
cord-306414-2dv3qced	142	24	the	the	DT
cord-306414-2dv3qced	142	25	same	same	JJ
cord-306414-2dv3qced	142	26	antigen	antigen	NN
cord-306414-2dv3qced	142	27	.	.	.
cord-306414-2dv3qced	143	1	Severe	severe	JJ
cord-306414-2dv3qced	143	2	acute	acute	JJ
cord-306414-2dv3qced	143	3	respiratory	respiratory	JJ
cord-306414-2dv3qced	143	4	syndrome	syndrome	NN
cord-306414-2dv3qced	143	5	coronavirus	coronavirus	NN
cord-306414-2dv3qced	143	6	2	2	CD
cord-306414-2dv3qced	144	1	(	(	-LRB-
cord-306414-2dv3qced	144	2	SARS	SARS	NNP
cord-306414-2dv3qced	144	3	-	-	HYPH
cord-306414-2dv3qced	144	4	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	144	5	)	)	-RRB-
cord-306414-2dv3qced	144	6	:	:	:
cord-306414-2dv3qced	144	7	severe	severe	JJ
cord-306414-2dv3qced	144	8	acute	acute	JJ
cord-306414-2dv3qced	144	9	respiratory	respiratory	JJ
cord-306414-2dv3qced	144	10	syndrome	syndrome	NN
cord-306414-2dv3qced	144	11	(	(	-LRB-
cord-306414-2dv3qced	144	12	SARS)-like	sars)-like	CD
cord-306414-2dv3qced	144	13	coronavirus	coronavirus	NN
cord-306414-2dv3qced	144	14	that	that	WDT
cord-306414-2dv3qced	144	15	belongs	belong	VBZ
cord-306414-2dv3qced	144	16	to	to	IN
cord-306414-2dv3qced	144	17	the	the	DT
cord-306414-2dv3qced	144	18	family	family	NN
cord-306414-2dv3qced	144	19	Coronaviridae	Coronaviridae	NNP
cord-306414-2dv3qced	144	20	and	and	CC
cord-306414-2dv3qced	144	21	the	the	DT
cord-306414-2dv3qced	144	22	subfamily	subfamily	NN
cord-306414-2dv3qced	144	23	Coronavirinae	Coronavirinae	NNP
cord-306414-2dv3qced	144	24	.	.	.
cord-306414-2dv3qced	145	1	It	-PRON-	PRP
cord-306414-2dv3qced	145	2	uses	use	VBZ
cord-306414-2dv3qced	145	3	the	the	DT
cord-306414-2dv3qced	145	4	angiotensinconverting	angiotensinconverting	NN
cord-306414-2dv3qced	145	5	enzyme	enzyme	NN
cord-306414-2dv3qced	145	6	2	2	CD
cord-306414-2dv3qced	145	7	(	(	-LRB-
cord-306414-2dv3qced	145	8	ACE	ACE	NNP
cord-306414-2dv3qced	145	9	2	2	CD
cord-306414-2dv3qced	145	10	)	)	-RRB-
cord-306414-2dv3qced	145	11	receptor	receptor	NN
cord-306414-2dv3qced	145	12	to	to	TO
cord-306414-2dv3qced	145	13	enter	enter	VB
cord-306414-2dv3qced	145	14	into	into	IN
cord-306414-2dv3qced	145	15	the	the	DT
cord-306414-2dv3qced	145	16	human	human	JJ
cord-306414-2dv3qced	145	17	cells	cell	NNS
cord-306414-2dv3qced	145	18	.	.	.
cord-306414-2dv3qced	146	1	It	-PRON-	PRP
cord-306414-2dv3qced	146	2	is	be	VBZ
cord-306414-2dv3qced	146	3	the	the	DT
cord-306414-2dv3qced	146	4	causative	causative	JJ
cord-306414-2dv3qced	146	5	agent	agent	NN
cord-306414-2dv3qced	146	6	of	of	IN
cord-306414-2dv3qced	146	7	COVID-19	COVID-19	NNP
cord-306414-2dv3qced	146	8	.	.	.
cord-306414-2dv3qced	147	1	T	T	NNP
cord-306414-2dv3qced	147	2	cell	cell	NN
cord-306414-2dv3qced	147	3	:	:	:
cord-306414-2dv3qced	147	4	white	white	JJ
cord-306414-2dv3qced	147	5	blood	blood	NN
cord-306414-2dv3qced	147	6	cells	cell	NNS
cord-306414-2dv3qced	147	7	that	that	WDT
cord-306414-2dv3qced	147	8	are	be	VBP
cord-306414-2dv3qced	147	9	important	important	JJ
cord-306414-2dv3qced	147	10	for	for	IN
cord-306414-2dv3qced	147	11	adaptive	adaptive	JJ
cord-306414-2dv3qced	147	12	immunity	immunity	NN
cord-306414-2dv3qced	147	13	.	.	.
cord-306414-2dv3qced	148	1	They	-PRON-	PRP
cord-306414-2dv3qced	148	2	have	have	VBP
cord-306414-2dv3qced	148	3	unique	unique	JJ
cord-306414-2dv3qced	148	4	cell	cell	NN
cord-306414-2dv3qced	148	5	surface	surface	NN
cord-306414-2dv3qced	148	6	receptors	receptor	NNS
cord-306414-2dv3qced	148	7	that	that	WDT
cord-306414-2dv3qced	148	8	are	be	VBP
cord-306414-2dv3qced	148	9	generated	generate	VBN
cord-306414-2dv3qced	148	10	by	by	IN
cord-306414-2dv3qced	148	11	randomly	randomly	RB
cord-306414-2dv3qced	148	12	assorting	assort	VBG
cord-306414-2dv3qced	148	13	genes	gene	NNS
cord-306414-2dv3qced	148	14	.	.	.
cord-306414-2dv3qced	149	1	These	these	DT
cord-306414-2dv3qced	149	2	receptors	receptor	NNS
cord-306414-2dv3qced	149	3	allow	allow	VBP
cord-306414-2dv3qced	149	4	T	t	NN
cord-306414-2dv3qced	149	5	cells	cell	NNS
cord-306414-2dv3qced	149	6	to	to	IN
cord-306414-2dv3qced	149	7	sense	sense	VB
cord-306414-2dv3qced	149	8	and	and	CC
cord-306414-2dv3qced	149	9	respond	respond	VB
cord-306414-2dv3qced	149	10	to	to	IN
cord-306414-2dv3qced	149	11	diverse	diverse	JJ
cord-306414-2dv3qced	149	12	types	type	NNS
cord-306414-2dv3qced	149	13	of	of	IN
cord-306414-2dv3qced	149	14	infection	infection	NN
cord-306414-2dv3qced	149	15	.	.	.
cord-306414-2dv3qced	150	1	T	T	NNP
cord-306414-2dv3qced	150	2	cell	cell	NN
cord-306414-2dv3qced	150	3	receptor	receptor	NN
cord-306414-2dv3qced	150	4	(	(	-LRB-
cord-306414-2dv3qced	150	5	TCR	TCR	NNP
cord-306414-2dv3qced	150	6	)	)	-RRB-
cord-306414-2dv3qced	150	7	:	:	:
cord-306414-2dv3qced	150	8	protein	protein	NN
cord-306414-2dv3qced	150	9	that	that	WDT
cord-306414-2dv3qced	150	10	recognizes	recognize	VBZ
cord-306414-2dv3qced	150	11	small	small	JJ
cord-306414-2dv3qced	150	12	protein	protein	NN
cord-306414-2dv3qced	150	13	fragments	fragment	NNS
cord-306414-2dv3qced	150	14	that	that	WDT
cord-306414-2dv3qced	150	15	are	be	VBP
cord-306414-2dv3qced	150	16	displayed	display	VBN
cord-306414-2dv3qced	150	17	by	by	IN
cord-306414-2dv3qced	150	18	the	the	DT
cord-306414-2dv3qced	150	19	MHC	MHC	NNP
cord-306414-2dv3qced	150	20	molecule	molecule	NN
cord-306414-2dv3qced	150	21	on	on	IN
cord-306414-2dv3qced	150	22	the	the	DT
cord-306414-2dv3qced	150	23	surface	surface	NN
cord-306414-2dv3qced	150	24	of	of	IN
cord-306414-2dv3qced	150	25	nucleated	nucleated	JJ
cord-306414-2dv3qced	150	26	cells	cell	NNS
cord-306414-2dv3qced	150	27	.	.	.
cord-306414-2dv3qced	151	1	Each	each	DT
cord-306414-2dv3qced	151	2	T	t	NN
cord-306414-2dv3qced	151	3	cell	cell	NN
cord-306414-2dv3qced	151	4	expresses	express	VBZ
cord-306414-2dv3qced	151	5	a	a	DT
cord-306414-2dv3qced	151	6	unique	unique	JJ
cord-306414-2dv3qced	151	7	TCR	TCR	NNP
cord-306414-2dv3qced	151	8	that	that	WDT
cord-306414-2dv3qced	151	9	is	be	VBZ
cord-306414-2dv3qced	151	10	generated	generate	VBN
cord-306414-2dv3qced	151	11	by	by	IN
cord-306414-2dv3qced	151	12	randomly	randomly	RB
cord-306414-2dv3qced	151	13	recombined	recombine	VBN
cord-306414-2dv3qced	151	14	genes	gene	NNS
cord-306414-2dv3qced	151	15	.	.	.
cord-306414-2dv3qced	152	1	This	this	DT
cord-306414-2dv3qced	152	2	ensures	ensure	VBZ
cord-306414-2dv3qced	152	3	that	that	IN
cord-306414-2dv3qced	152	4	T	t	NN
cord-306414-2dv3qced	152	5	cells	cell	NNS
cord-306414-2dv3qced	152	6	can	can	MD
cord-306414-2dv3qced	152	7	convergent	convergent	JJ
cord-306414-2dv3qced	152	8	TCRβ	tcrβ	NN
cord-306414-2dv3qced	152	9	repertoire	repertoire	NN
cord-306414-2dv3qced	152	10	evolution	evolution	NN
cord-306414-2dv3qced	152	11	in	in	IN
cord-306414-2dv3qced	152	12	large	large	JJ
cord-306414-2dv3qced	152	13	cohorts	cohort	NNS
cord-306414-2dv3qced	152	14	of	of	IN
cord-306414-2dv3qced	152	15	unrelated	unrelated	JJ
cord-306414-2dv3qced	152	16	individuals	individual	NNS
cord-306414-2dv3qced	152	17	infected	infect	VBN
cord-306414-2dv3qced	152	18	with	with	IN
cord-306414-2dv3qced	152	19	CMV	CMV	NNP
cord-306414-2dv3qced	152	20	or	or	CC
cord-306414-2dv3qced	152	21	vaccinated	vaccinate	VBN
cord-306414-2dv3qced	152	22	against	against	IN
cord-306414-2dv3qced	152	23	yellow	yellow	JJ
cord-306414-2dv3qced	152	24	fever	fever	NN
cord-306414-2dv3qced	152	25	[	[	-LRB-
cord-306414-2dv3qced	152	26	57	57	CD
cord-306414-2dv3qced	152	27	,	,	,
cord-306414-2dv3qced	152	28	58	58	CD
cord-306414-2dv3qced	152	29	]	]	-RRB-
cord-306414-2dv3qced	152	30	.	.	.
cord-306414-2dv3qced	153	1	Additional	additional	JJ
cord-306414-2dv3qced	153	2	work	work	NN
cord-306414-2dv3qced	153	3	has	have	VBZ
cord-306414-2dv3qced	153	4	demonstrated	demonstrate	VBN
cord-306414-2dv3qced	153	5	that	that	IN
cord-306414-2dv3qced	153	6	information	information	NN
cord-306414-2dv3qced	153	7	obtained	obtain	VBN
cord-306414-2dv3qced	153	8	from	from	IN
cord-306414-2dv3qced	153	9	public	public	JJ
cord-306414-2dv3qced	153	10	TCRs	tcr	NNS
cord-306414-2dv3qced	153	11	in	in	IN
cord-306414-2dv3qced	153	12	smallpox	smallpox	NN
cord-306414-2dv3qced	153	13	vaccinated	vaccinate	VBD
cord-306414-2dv3qced	153	14	mice	mouse	NNS
cord-306414-2dv3qced	153	15	can	can	MD
cord-306414-2dv3qced	153	16	be	be	VB
cord-306414-2dv3qced	153	17	used	use	VBN
cord-306414-2dv3qced	153	18	to	to	TO
cord-306414-2dv3qced	153	19	identify	identify	VB
cord-306414-2dv3qced	153	20	smallpox	smallpox	NN
cord-306414-2dv3qced	153	21	vaccinated	vaccinate	VBN
cord-306414-2dv3qced	153	22	mice	mouse	NNS
cord-306414-2dv3qced	153	23	with	with	IN
cord-306414-2dv3qced	153	24	N99	N99	NNP
cord-306414-2dv3qced	153	25	%	%	NN
cord-306414-2dv3qced	153	26	accuracy	accuracy	NN
cord-306414-2dv3qced	153	27	[	[	-LRB-
cord-306414-2dv3qced	153	28	59	59	CD
cord-306414-2dv3qced	153	29	]	]	-RRB-
cord-306414-2dv3qced	153	30	.	.	.
cord-306414-2dv3qced	154	1	Also	also	RB
cord-306414-2dv3qced	154	2	,	,	,
cord-306414-2dv3qced	154	3	it	-PRON-	PRP
cord-306414-2dv3qced	154	4	has	have	VBZ
cord-306414-2dv3qced	154	5	been	be	VBN
cord-306414-2dv3qced	154	6	demonstrated	demonstrate	VBN
cord-306414-2dv3qced	154	7	that	that	IN
cord-306414-2dv3qced	154	8	influenza	influenza	NN
cord-306414-2dv3qced	154	9	A	a	DT
cord-306414-2dv3qced	154	10	infection	infection	NN
cord-306414-2dv3qced	154	11	induces	induce	VBZ
cord-306414-2dv3qced	154	12	a	a	DT
cord-306414-2dv3qced	154	13	polyclonal	polyclonal	JJ
cord-306414-2dv3qced	154	14	T	t	NN
cord-306414-2dv3qced	154	15	cell	cell	NN
cord-306414-2dv3qced	154	16	response	response	NN
cord-306414-2dv3qced	154	17	in	in	IN
cord-306414-2dv3qced	154	18	patients	patient	NNS
cord-306414-2dv3qced	154	19	,	,	,
cord-306414-2dv3qced	154	20	by	by	IN
cord-306414-2dv3qced	154	21	TCRs	TCRs	NNP
cord-306414-2dv3qced	154	22	predominantly	predominantly	RB
cord-306414-2dv3qced	154	23	utilizing	utilize	VBG
cord-306414-2dv3qced	154	24	TRBV19	TRBV19	NNP
cord-306414-2dv3qced	154	25	gene	gene	NN
cord-306414-2dv3qced	154	26	[	[	-LRB-
cord-306414-2dv3qced	154	27	60	60	CD
cord-306414-2dv3qced	154	28	]	]	-RRB-
cord-306414-2dv3qced	154	29	.	.	.
cord-306414-2dv3qced	155	1	Collectively	collectively	RB
cord-306414-2dv3qced	155	2	,	,	,
cord-306414-2dv3qced	155	3	these	these	DT
cord-306414-2dv3qced	155	4	studies	study	NNS
cord-306414-2dv3qced	155	5	suggest	suggest	VBP
cord-306414-2dv3qced	155	6	that	that	IN
cord-306414-2dv3qced	155	7	the	the	DT
cord-306414-2dv3qced	155	8	TCR	TCR	NNP
cord-306414-2dv3qced	155	9	repertoire	repertoire	NN
cord-306414-2dv3qced	155	10	changes	change	NNS
cord-306414-2dv3qced	155	11	in	in	IN
cord-306414-2dv3qced	155	12	response	response	NN
cord-306414-2dv3qced	155	13	to	to	IN
cord-306414-2dv3qced	155	14	infection	infection	NN
cord-306414-2dv3qced	155	15	or	or	CC
cord-306414-2dv3qced	155	16	vaccination	vaccination	NN
cord-306414-2dv3qced	155	17	in	in	IN
cord-306414-2dv3qced	155	18	a	a	DT
cord-306414-2dv3qced	155	19	potentially	potentially	RB
cord-306414-2dv3qced	155	20	predictable	predictable	JJ
cord-306414-2dv3qced	155	21	manner	manner	NN
cord-306414-2dv3qced	155	22	and	and	CC
cord-306414-2dv3qced	155	23	can	can	MD
cord-306414-2dv3qced	155	24	therefore	therefore	RB
cord-306414-2dv3qced	155	25	be	be	VB
cord-306414-2dv3qced	155	26	leveraged	leverage	VBN
cord-306414-2dv3qced	155	27	to	to	TO
cord-306414-2dv3qced	155	28	identify	identify	VB
cord-306414-2dv3qced	155	29	clones	clone	NNS
cord-306414-2dv3qced	155	30	against	against	IN
cord-306414-2dv3qced	155	31	SARS	SARS	NNP
cord-306414-2dv3qced	155	32	-	-	HYPH
cord-306414-2dv3qced	155	33	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	155	34	.	.	.
cord-306414-2dv3qced	156	1	Thus	thus	RB
cord-306414-2dv3qced	156	2	,	,	,
cord-306414-2dv3qced	156	3	TCR	TCR	NNP
cord-306414-2dv3qced	156	4	repertoire	repertoire	NN
cord-306414-2dv3qced	156	5	profiling	profiling	NN
cord-306414-2dv3qced	156	6	in	in	IN
cord-306414-2dv3qced	156	7	COVID-19	covid-19	JJ
cord-306414-2dv3qced	156	8	patients	patient	NNS
cord-306414-2dv3qced	156	9	after	after	IN
cord-306414-2dv3qced	156	10	recovery	recovery	NN
cord-306414-2dv3qced	156	11	may	may	MD
cord-306414-2dv3qced	156	12	uncover	uncover	VB
cord-306414-2dv3qced	156	13	SARS	SARS	NNP
cord-306414-2dv3qced	156	14	-	-	HYPH
cord-306414-2dv3qced	156	15	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	156	16	reactive	reactive	JJ
cord-306414-2dv3qced	156	17	clones	clone	NNS
cord-306414-2dv3qced	156	18	and/or	and/or	CC
cord-306414-2dv3qced	156	19	general	general	JJ
cord-306414-2dv3qced	156	20	TCR	TCR	NNP
cord-306414-2dv3qced	156	21	repertoire	repertoire	NN
cord-306414-2dv3qced	157	1	features	feature	NNS
cord-306414-2dv3qced	157	2	that	that	WDT
cord-306414-2dv3qced	157	3	differentiate	differentiate	VBP
cord-306414-2dv3qced	157	4	patients	patient	NNS
cord-306414-2dv3qced	157	5	with	with	IN
cord-306414-2dv3qced	157	6	prior	prior	JJ
cord-306414-2dv3qced	157	7	infection	infection	NN
cord-306414-2dv3qced	157	8	from	from	IN
cord-306414-2dv3qced	157	9	those	those	DT
cord-306414-2dv3qced	157	10	that	that	WDT
cord-306414-2dv3qced	157	11	have	have	VBP
cord-306414-2dv3qced	157	12	never	never	RB
cord-306414-2dv3qced	157	13	been	be	VBN
cord-306414-2dv3qced	157	14	infected	infect	VBN
cord-306414-2dv3qced	158	1	(	(	-LRB-
cord-306414-2dv3qced	158	2	Figure	figure	NN
cord-306414-2dv3qced	158	3	3A	3a	CD
cord-306414-2dv3qced	158	4	)	)	-RRB-
cord-306414-2dv3qced	158	5	.	.	.
cord-306414-2dv3qced	159	1	TCR	TCR	NNP
cord-306414-2dv3qced	159	2	repertoire	repertoire	NN
cord-306414-2dv3qced	159	3	profiling	profiling	NN
cord-306414-2dv3qced	159	4	combined	combine	VBN
cord-306414-2dv3qced	159	5	with	with	IN
cord-306414-2dv3qced	159	6	computational	computational	JJ
cord-306414-2dv3qced	159	7	strategies	strategy	NNS
cord-306414-2dv3qced	159	8	may	may	MD
cord-306414-2dv3qced	159	9	also	also	RB
cord-306414-2dv3qced	159	10	enable	enable	VB
cord-306414-2dv3qced	159	11	the	the	DT
cord-306414-2dv3qced	159	12	identification	identification	NN
cord-306414-2dv3qced	159	13	of	of	IN
cord-306414-2dv3qced	159	14	SARS	SARS	NNP
cord-306414-2dv3qced	159	15	-	-	HYPH
cord-306414-2dv3qced	159	16	CoV-2-specific	CoV-2-specific	NNP
cord-306414-2dv3qced	159	17	TCR	TCR	NNP
cord-306414-2dv3qced	159	18	clones	clone	NNS
cord-306414-2dv3qced	159	19	and	and	CC
cord-306414-2dv3qced	159	20	general	general	JJ
cord-306414-2dv3qced	159	21	TCR	TCR	NNP
cord-306414-2dv3qced	159	22	repertoire	repertoire	NN
cord-306414-2dv3qced	159	23	signatures	signature	NNS
cord-306414-2dv3qced	159	24	that	that	WDT
cord-306414-2dv3qced	159	25	may	may	MD
cord-306414-2dv3qced	159	26	serve	serve	VB
cord-306414-2dv3qced	159	27	as	as	IN
cord-306414-2dv3qced	159	28	a	a	DT
cord-306414-2dv3qced	159	29	biomarker	biomarker	NN
cord-306414-2dv3qced	159	30	for	for	IN
cord-306414-2dv3qced	159	31	herd	herd	NN
cord-306414-2dv3qced	159	32	immunity	immunity	NN
cord-306414-2dv3qced	159	33	at	at	IN
cord-306414-2dv3qced	159	34	the	the	DT
cord-306414-2dv3qced	159	35	population	population	NN
cord-306414-2dv3qced	159	36	level	level	NN
cord-306414-2dv3qced	159	37	(	(	-LRB-
cord-306414-2dv3qced	159	38	Figure	figure	NN
cord-306414-2dv3qced	159	39	3B	3b	CD
cord-306414-2dv3qced	159	40	)	)	-RRB-
cord-306414-2dv3qced	159	41	.	.	.
cord-306414-2dv3qced	160	1	Adoptive	adoptive	JJ
cord-306414-2dv3qced	160	2	transfer	transfer	NN
cord-306414-2dv3qced	160	3	of	of	IN
cord-306414-2dv3qced	160	4	TCR	TCR	NNP
cord-306414-2dv3qced	160	5	engineered	engineer	VBD
cord-306414-2dv3qced	160	6	T	t	NN
cord-306414-2dv3qced	160	7	cell	cell	NN
cord-306414-2dv3qced	160	8	(	(	-LRB-
cord-306414-2dv3qced	160	9	TCR	TCR	NNP
cord-306414-2dv3qced	160	10	-	-	HYPH
cord-306414-2dv3qced	160	11	T	T	NNP
cord-306414-2dv3qced	160	12	)	)	-RRB-
cord-306414-2dv3qced	160	13	has	have	VBZ
cord-306414-2dv3qced	160	14	been	be	VBN
cord-306414-2dv3qced	160	15	applied	apply	VBN
cord-306414-2dv3qced	160	16	to	to	TO
cord-306414-2dv3qced	160	17	treat	treat	VB
cord-306414-2dv3qced	160	18	viral	viral	JJ
cord-306414-2dv3qced	160	19	infections	infection	NNS
cord-306414-2dv3qced	160	20	such	such	JJ
cord-306414-2dv3qced	160	21	as	as	IN
cord-306414-2dv3qced	160	22	hepatitis	hepatitis	NN
cord-306414-2dv3qced	160	23	B	B	NNP
cord-306414-2dv3qced	160	24	and	and	CC
cord-306414-2dv3qced	160	25	C	C	NNP
cord-306414-2dv3qced	160	26	[	[	-LRB-
cord-306414-2dv3qced	160	27	61	61	CD
cord-306414-2dv3qced	160	28	,	,	,
cord-306414-2dv3qced	160	29	62	62	CD
cord-306414-2dv3qced	160	30	]	]	-RRB-
cord-306414-2dv3qced	160	31	.	.	.
cord-306414-2dv3qced	161	1	This	this	DT
cord-306414-2dv3qced	161	2	was	be	VBD
cord-306414-2dv3qced	161	3	also	also	RB
cord-306414-2dv3qced	161	4	demonstrated	demonstrate	VBN
cord-306414-2dv3qced	161	5	in	in	IN
cord-306414-2dv3qced	161	6	preclinical	preclinical	JJ
cord-306414-2dv3qced	161	7	models	model	NNS
cord-306414-2dv3qced	161	8	for	for	IN
cord-306414-2dv3qced	161	9	prior	prior	JJ
cord-306414-2dv3qced	161	10	coronaviruses	coronaviruse	NNS
cord-306414-2dv3qced	161	11	such	such	JJ
cord-306414-2dv3qced	161	12	as	as	IN
cord-306414-2dv3qced	161	13	SARS	SARS	NNP
cord-306414-2dv3qced	161	14	;	;	,
cord-306414-2dv3qced	161	15	engineered	engineer	VBN
cord-306414-2dv3qced	161	16	SARS	SARS	NNP
cord-306414-2dv3qced	161	17	-	-	HYPH
cord-306414-2dv3qced	161	18	CoV	cov	NN
cord-306414-2dv3qced	161	19	-	-	HYPH
cord-306414-2dv3qced	161	20	specific	specific	JJ
cord-306414-2dv3qced	161	21	TCR	TCR	NNP
cord-306414-2dv3qced	161	22	-	-	HYPH
cord-306414-2dv3qced	161	23	T	T	NNP
cord-306414-2dv3qced	161	24	cells	cell	NNS
cord-306414-2dv3qced	161	25	from	from	IN
cord-306414-2dv3qced	161	26	normal	normal	JJ
cord-306414-2dv3qced	161	27	individuals	individual	NNS
cord-306414-2dv3qced	161	28	have	have	VBP
cord-306414-2dv3qced	161	29	demonstrated	demonstrate	VBN
cord-306414-2dv3qced	161	30	antiviral	antiviral	JJ
cord-306414-2dv3qced	161	31	activity	activity	NN
cord-306414-2dv3qced	161	32	that	that	WDT
cord-306414-2dv3qced	161	33	was	be	VBD
cord-306414-2dv3qced	161	34	comparable	comparable	JJ
cord-306414-2dv3qced	161	35	with	with	IN
cord-306414-2dv3qced	161	36	that	that	DT
cord-306414-2dv3qced	161	37	of	of	IN
cord-306414-2dv3qced	161	38	natural	natural	JJ
cord-306414-2dv3qced	161	39	SARS	SARS	NNP
cord-306414-2dv3qced	161	40	-	-	HYPH
cord-306414-2dv3qced	161	41	CoVspecific	CoVspecific	NNP
cord-306414-2dv3qced	161	42	memory	memory	NN
cord-306414-2dv3qced	161	43	CD8	CD8	NNP
cord-306414-2dv3qced	161	44	+	+	CC
cord-306414-2dv3qced	161	45	T	T	NNP
cord-306414-2dv3qced	161	46	cells	cell	NNS
cord-306414-2dv3qced	161	47	[	[	-LRB-
cord-306414-2dv3qced	161	48	63	63	CD
cord-306414-2dv3qced	161	49	]	]	-RRB-
cord-306414-2dv3qced	161	50	.	.	.
cord-306414-2dv3qced	162	1	The	the	DT
cord-306414-2dv3qced	162	2	ability	ability	NN
cord-306414-2dv3qced	162	3	to	to	TO
cord-306414-2dv3qced	162	4	identify	identify	VB
cord-306414-2dv3qced	162	5	potential	potential	JJ
cord-306414-2dv3qced	162	6	TCR	TCR	NNP
cord-306414-2dv3qced	162	7	clones	clone	NNS
cord-306414-2dv3qced	162	8	that	that	WDT
cord-306414-2dv3qced	162	9	are	be	VBP
cord-306414-2dv3qced	162	10	specific	specific	JJ
cord-306414-2dv3qced	162	11	to	to	IN
cord-306414-2dv3qced	162	12	SARS	SARS	NNP
cord-306414-2dv3qced	162	13	-	-	HYPH
cord-306414-2dv3qced	162	14	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	162	15	antigens	antigen	NNS
cord-306414-2dv3qced	162	16	can	can	MD
cord-306414-2dv3qced	162	17	be	be	VB
cord-306414-2dv3qced	162	18	leveraged	leverage	VBN
cord-306414-2dv3qced	162	19	in	in	IN
cord-306414-2dv3qced	162	20	the	the	DT
cord-306414-2dv3qced	162	21	development	development	NN
cord-306414-2dv3qced	162	22	of	of	IN
cord-306414-2dv3qced	162	23	highly	highly	RB
cord-306414-2dv3qced	162	24	specific	specific	JJ
cord-306414-2dv3qced	162	25	and	and	CC
cord-306414-2dv3qced	162	26	advanced	advanced	JJ
cord-306414-2dv3qced	162	27	forms	form	NNS
cord-306414-2dv3qced	162	28	of	of	IN
cord-306414-2dv3qced	162	29	immunotherapy	immunotherapy	NN
cord-306414-2dv3qced	162	30	based	base	VBN
cord-306414-2dv3qced	162	31	on	on	IN
cord-306414-2dv3qced	162	32	TCR	TCR	NNP
cord-306414-2dv3qced	162	33	structural	structural	JJ
cord-306414-2dv3qced	162	34	and	and	CC
cord-306414-2dv3qced	162	35	sequence	sequence	NN
cord-306414-2dv3qced	162	36	information	information	NN
cord-306414-2dv3qced	162	37	.	.	.
cord-306414-2dv3qced	163	1	Identification	identification	NN
cord-306414-2dv3qced	163	2	of	of	IN
cord-306414-2dv3qced	163	3	public	public	JJ
cord-306414-2dv3qced	163	4	clones	clone	NNS
cord-306414-2dv3qced	163	5	through	through	IN
cord-306414-2dv3qced	163	6	TCR	TCR	NNP
cord-306414-2dv3qced	163	7	repertoire	repertoire	NN
cord-306414-2dv3qced	163	8	profiling	profiling	NN
cord-306414-2dv3qced	163	9	in	in	IN
cord-306414-2dv3qced	163	10	infected	infected	JJ
cord-306414-2dv3qced	163	11	and	and	CC
cord-306414-2dv3qced	163	12	vaccinated	vaccinate	VBN
cord-306414-2dv3qced	163	13	individuals	individual	NNS
cord-306414-2dv3qced	163	14	may	may	MD
cord-306414-2dv3qced	163	15	guide	guide	VB
cord-306414-2dv3qced	163	16	the	the	DT
cord-306414-2dv3qced	163	17	design	design	NN
cord-306414-2dv3qced	163	18	of	of	IN
cord-306414-2dv3qced	163	19	future	future	JJ
cord-306414-2dv3qced	163	20	TCR	TCR	NNP
cord-306414-2dv3qced	163	21	-	-	HYPH
cord-306414-2dv3qced	163	22	T	T	NNP
cord-306414-2dv3qced	163	23	immunotherapies	immunotherapy	NNS
cord-306414-2dv3qced	163	24	against	against	IN
cord-306414-2dv3qced	163	25	SARS	SARS	NNP
cord-306414-2dv3qced	163	26	-	-	HYPH
cord-306414-2dv3qced	163	27	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	163	28	.	.	.
cord-306414-2dv3qced	164	1	SARS	SARS	NNP
cord-306414-2dv3qced	164	2	-	-	HYPH
cord-306414-2dv3qced	164	3	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	164	4	reactive	reactive	JJ
cord-306414-2dv3qced	164	5	T	t	NN
cord-306414-2dv3qced	164	6	cells	cell	NNS
cord-306414-2dv3qced	164	7	can	can	MD
cord-306414-2dv3qced	164	8	be	be	VB
cord-306414-2dv3qced	164	9	expanded	expand	VBN
cord-306414-2dv3qced	164	10	ex	ex	FW
cord-306414-2dv3qced	164	11	vivo	vivo	NN
cord-306414-2dv3qced	164	12	and	and	CC
cord-306414-2dv3qced	164	13	infused	infuse	VBN
cord-306414-2dv3qced	164	14	directly	directly	RB
cord-306414-2dv3qced	164	15	into	into	IN
cord-306414-2dv3qced	164	16	an	an	DT
cord-306414-2dv3qced	164	17	individual	individual	NN
cord-306414-2dv3qced	164	18	to	to	TO
cord-306414-2dv3qced	164	19	shorten	shorten	VB
cord-306414-2dv3qced	164	20	recovery	recovery	NN
cord-306414-2dv3qced	164	21	time	time	NN
cord-306414-2dv3qced	164	22	and	and	CC
cord-306414-2dv3qced	164	23	increase	increase	VB
cord-306414-2dv3qced	164	24	the	the	DT
cord-306414-2dv3qced	164	25	magnitude	magnitude	NN
cord-306414-2dv3qced	164	26	of	of	IN
cord-306414-2dv3qced	164	27	response	response	NN
cord-306414-2dv3qced	165	1	(	(	-LRB-
cord-306414-2dv3qced	165	2	Figure	figure	NN
cord-306414-2dv3qced	165	3	4	4	CD
cord-306414-2dv3qced	165	4	)	)	-RRB-
cord-306414-2dv3qced	165	5	.	.	.
cord-306414-2dv3qced	166	1	TCR	TCR	NNP
cord-306414-2dv3qced	166	2	Repertoire	repertoire	NN
cord-306414-2dv3qced	166	3	Changes	change	VBZ
cord-306414-2dv3qced	166	4	as	as	IN
cord-306414-2dv3qced	166	5	a	a	DT
cord-306414-2dv3qced	166	6	Measure	measure	NN
cord-306414-2dv3qced	166	7	of	of	IN
cord-306414-2dv3qced	166	8	Clinical	clinical	JJ
cord-306414-2dv3qced	166	9	Outcome	outcome	NN
cord-306414-2dv3qced	166	10	TCR	TCR	NNP
cord-306414-2dv3qced	167	1	repertoire	repertoire	NN
cord-306414-2dv3qced	167	2	composition	composition	NN
cord-306414-2dv3qced	167	3	and	and	CC
cord-306414-2dv3qced	167	4	diversity	diversity	NN
cord-306414-2dv3qced	167	5	are	be	VBP
cord-306414-2dv3qced	167	6	major	major	JJ
cord-306414-2dv3qced	167	7	determinants	determinant	NNS
cord-306414-2dv3qced	167	8	of	of	IN
cord-306414-2dv3qced	167	9	disease	disease	NN
cord-306414-2dv3qced	167	10	outcomes	outcome	NNS
cord-306414-2dv3qced	167	11	following	follow	VBG
cord-306414-2dv3qced	167	12	viral	viral	JJ
cord-306414-2dv3qced	167	13	infection	infection	NN
cord-306414-2dv3qced	167	14	.	.	.
cord-306414-2dv3qced	168	1	Multiple	multiple	JJ
cord-306414-2dv3qced	168	2	studies	study	NNS
cord-306414-2dv3qced	168	3	have	have	VBP
cord-306414-2dv3qced	168	4	provided	provide	VBN
cord-306414-2dv3qced	168	5	clear	clear	JJ
cord-306414-2dv3qced	168	6	evidence	evidence	NN
cord-306414-2dv3qced	168	7	indicating	indicate	VBG
cord-306414-2dv3qced	168	8	a	a	DT
cord-306414-2dv3qced	168	9	highly	highly	RB
cord-306414-2dv3qced	168	10	diverse	diverse	JJ
cord-306414-2dv3qced	168	11	TCR	TCR	NNP
cord-306414-2dv3qced	168	12	repertoire	repertoire	NN
cord-306414-2dv3qced	168	13	provides	provide	VBZ
cord-306414-2dv3qced	168	14	protection	protection	NN
cord-306414-2dv3qced	168	15	against	against	IN
cord-306414-2dv3qced	168	16	a	a	DT
cord-306414-2dv3qced	168	17	wide	wide	JJ
cord-306414-2dv3qced	168	18	array	array	NN
cord-306414-2dv3qced	168	19	of	of	IN
cord-306414-2dv3qced	168	20	antigens	antigen	NNS
cord-306414-2dv3qced	168	21	[	[	-LRB-
cord-306414-2dv3qced	168	22	22	22	CD
cord-306414-2dv3qced	168	23	,	,	,
cord-306414-2dv3qced	168	24	64	64	CD
cord-306414-2dv3qced	168	25	,	,	,
cord-306414-2dv3qced	168	26	65	65	CD
cord-306414-2dv3qced	168	27	]	]	-RRB-
cord-306414-2dv3qced	168	28	.	.	.
cord-306414-2dv3qced	169	1	It	-PRON-	PRP
cord-306414-2dv3qced	169	2	is	be	VBZ
cord-306414-2dv3qced	169	3	possible	possible	JJ
cord-306414-2dv3qced	169	4	that	that	IN
cord-306414-2dv3qced	169	5	a	a	DT
cord-306414-2dv3qced	169	6	highly	highly	RB
cord-306414-2dv3qced	169	7	diverse	diverse	JJ
cord-306414-2dv3qced	169	8	TCR	TCR	NNP
cord-306414-2dv3qced	169	9	repertoire	repertoire	NN
cord-306414-2dv3qced	169	10	can	can	MD
cord-306414-2dv3qced	169	11	allow	allow	VB
cord-306414-2dv3qced	169	12	for	for	IN
cord-306414-2dv3qced	169	13	the	the	DT
cord-306414-2dv3qced	169	14	right	right	JJ
cord-306414-2dv3qced	169	15	amount	amount	NN
cord-306414-2dv3qced	169	16	of	of	IN
cord-306414-2dv3qced	169	17	avidity	avidity	NN
cord-306414-2dv3qced	169	18	,	,	,
cord-306414-2dv3qced	169	19	affinity	affinity	NN
cord-306414-2dv3qced	169	20	,	,	,
cord-306414-2dv3qced	169	21	and	and	CC
cord-306414-2dv3qced	169	22	overall	overall	JJ
cord-306414-2dv3qced	169	23	function	function	NN
cord-306414-2dv3qced	169	24	[	[	-LRB-
cord-306414-2dv3qced	169	25	66	66	CD
cord-306414-2dv3qced	169	26	,	,	,
cord-306414-2dv3qced	169	27	67	67	CD
cord-306414-2dv3qced	169	28	]	]	-RRB-
cord-306414-2dv3qced	169	29	.	.	.
cord-306414-2dv3qced	170	1	Similar	similar	JJ
cord-306414-2dv3qced	170	2	studies	study	NNS
cord-306414-2dv3qced	170	3	can	can	MD
cord-306414-2dv3qced	170	4	be	be	VB
cord-306414-2dv3qced	170	5	performed	perform	VBN
cord-306414-2dv3qced	170	6	to	to	TO
cord-306414-2dv3qced	170	7	track	track	VB
cord-306414-2dv3qced	170	8	changes	change	NNS
cord-306414-2dv3qced	170	9	in	in	IN
cord-306414-2dv3qced	170	10	the	the	DT
cord-306414-2dv3qced	170	11	TCR	TCR	NNP
cord-306414-2dv3qced	170	12	repertoire	repertoire	NN
cord-306414-2dv3qced	170	13	in	in	IN
cord-306414-2dv3qced	170	14	SARS	SARS	NNP
cord-306414-2dv3qced	170	15	-	-	HYPH
cord-306414-2dv3qced	170	16	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	170	17	positive	positive	JJ
cord-306414-2dv3qced	170	18	individuals	individual	NNS
cord-306414-2dv3qced	170	19	,	,	,
cord-306414-2dv3qced	170	20	beginning	begin	VBG
cord-306414-2dv3qced	170	21	at	at	IN
cord-306414-2dv3qced	170	22	hospitalization	hospitalization	NN
cord-306414-2dv3qced	170	23	,	,	,
cord-306414-2dv3qced	170	24	to	to	TO
cord-306414-2dv3qced	170	25	precisely	precisely	RB
cord-306414-2dv3qced	170	26	identify	identify	VB
cord-306414-2dv3qced	170	27	changes	change	NNS
cord-306414-2dv3qced	170	28	in	in	IN
cord-306414-2dv3qced	170	29	the	the	DT
cord-306414-2dv3qced	170	30	TCR	TCR	NNP
cord-306414-2dv3qced	170	31	repertoire	repertoire	NN
cord-306414-2dv3qced	170	32	and	and	CC
cord-306414-2dv3qced	170	33	composition	composition	NN
cord-306414-2dv3qced	170	34	throughout	throughout	IN
cord-306414-2dv3qced	170	35	disease	disease	NN
cord-306414-2dv3qced	170	36	progression	progression	NN
cord-306414-2dv3qced	170	37	.	.	.
cord-306414-2dv3qced	171	1	By	by	IN
cord-306414-2dv3qced	171	2	examining	examine	VBG
cord-306414-2dv3qced	171	3	the	the	DT
cord-306414-2dv3qced	171	4	TCR	TCR	NNP
cord-306414-2dv3qced	171	5	repertoire	repertoire	NN
cord-306414-2dv3qced	171	6	composition	composition	NN
cord-306414-2dv3qced	171	7	and	and	CC
cord-306414-2dv3qced	171	8	diversity	diversity	NN
cord-306414-2dv3qced	171	9	in	in	IN
cord-306414-2dv3qced	171	10	a	a	DT
cord-306414-2dv3qced	171	11	large	large	JJ
cord-306414-2dv3qced	171	12	patient	patient	JJ
cord-306414-2dv3qced	171	13	population	population	NN
cord-306414-2dv3qced	171	14	,	,	,
cord-306414-2dv3qced	171	15	beginning	begin	VBG
cord-306414-2dv3qced	171	16	at	at	IN
cord-306414-2dv3qced	171	17	early	early	JJ
cord-306414-2dv3qced	171	18	stages	stage	NNS
cord-306414-2dv3qced	171	19	of	of	IN
cord-306414-2dv3qced	171	20	infection	infection	NN
cord-306414-2dv3qced	171	21	,	,	,
cord-306414-2dv3qced	171	22	we	-PRON-	PRP
cord-306414-2dv3qced	171	23	may	may	MD
cord-306414-2dv3qced	171	24	be	be	VB
cord-306414-2dv3qced	171	25	able	able	JJ
cord-306414-2dv3qced	171	26	to	to	TO
cord-306414-2dv3qced	171	27	understand	understand	VB
cord-306414-2dv3qced	171	28	how	how	WRB
cord-306414-2dv3qced	171	29	these	these	DT
cord-306414-2dv3qced	171	30	two	two	CD
cord-306414-2dv3qced	171	31	parameters	parameter	NNS
cord-306414-2dv3qced	171	32	change	change	VBP
cord-306414-2dv3qced	171	33	in	in	IN
cord-306414-2dv3qced	171	34	association	association	NN
cord-306414-2dv3qced	171	35	with	with	IN
cord-306414-2dv3qced	171	36	immune	immune	JJ
cord-306414-2dv3qced	171	37	response	response	NN
cord-306414-2dv3qced	171	38	and	and	CC
cord-306414-2dv3qced	171	39	outcomes	outcome	NNS
cord-306414-2dv3qced	171	40	in	in	IN
cord-306414-2dv3qced	171	41	COVID-19	covid-19	CD
cord-306414-2dv3qced	171	42	patients	patient	NNS
cord-306414-2dv3qced	171	43	.	.	.
cord-306414-2dv3qced	172	1	Biological	biological	JJ
cord-306414-2dv3qced	172	2	Samples	sample	NNS
cord-306414-2dv3qced	173	1	The	the	DT
cord-306414-2dv3qced	173	2	selection	selection	NN
cord-306414-2dv3qced	173	3	of	of	IN
cord-306414-2dv3qced	173	4	proper	proper	JJ
cord-306414-2dv3qced	173	5	biological	biological	JJ
cord-306414-2dv3qced	173	6	samples	sample	NNS
cord-306414-2dv3qced	173	7	and	and	CC
cord-306414-2dv3qced	173	8	determining	determine	VBG
cord-306414-2dv3qced	173	9	an	an	DT
cord-306414-2dv3qced	173	10	appropriate	appropriate	JJ
cord-306414-2dv3qced	173	11	collection	collection	NN
cord-306414-2dv3qced	173	12	schedule	schedule	NN
cord-306414-2dv3qced	173	13	is	be	VBZ
cord-306414-2dv3qced	173	14	crucial	crucial	JJ
cord-306414-2dv3qced	173	15	to	to	TO
cord-306414-2dv3qced	173	16	prepare	prepare	VB
cord-306414-2dv3qced	173	17	the	the	DT
cord-306414-2dv3qced	173	18	input	input	NN
cord-306414-2dv3qced	173	19	for	for	IN
cord-306414-2dv3qced	173	20	TCR	TCR	NNP
cord-306414-2dv3qced	173	21	analysis	analysis	NN
cord-306414-2dv3qced	173	22	.	.	.
cord-306414-2dv3qced	174	1	Sputum	sputum	NN
cord-306414-2dv3qced	174	2	samples	sample	NNS
cord-306414-2dv3qced	174	3	,	,	,
cord-306414-2dv3qced	174	4	while	while	IN
cord-306414-2dv3qced	174	5	feasible	feasible	JJ
cord-306414-2dv3qced	174	6	,	,	,
cord-306414-2dv3qced	174	7	may	may	MD
cord-306414-2dv3qced	174	8	not	not	RB
cord-306414-2dv3qced	174	9	offer	offer	VB
cord-306414-2dv3qced	174	10	sufficient	sufficient	JJ
cord-306414-2dv3qced	174	11	depth	depth	NN
cord-306414-2dv3qced	174	12	of	of	IN
cord-306414-2dv3qced	174	13	the	the	DT
cord-306414-2dv3qced	174	14	TCR	TCR	NNP
cord-306414-2dv3qced	174	15	repertoire	repertoire	NN
cord-306414-2dv3qced	174	16	sequencing	sequencing	NN
cord-306414-2dv3qced	174	17	,	,	,
cord-306414-2dv3qced	174	18	as	as	IN
cord-306414-2dv3qced	174	19	the	the	DT
cord-306414-2dv3qced	174	20	number	number	NN
cord-306414-2dv3qced	174	21	of	of	IN
cord-306414-2dv3qced	174	22	CD8	CD8	NNP
cord-306414-2dv3qced	174	23	+	+	CC
cord-306414-2dv3qced	174	24	T	T	NNP
cord-306414-2dv3qced	174	25	cells	cell	NNS
cord-306414-2dv3qced	174	26	in	in	IN
cord-306414-2dv3qced	174	27	sputum	sputum	NN
cord-306414-2dv3qced	174	28	,	,	,
cord-306414-2dv3qced	174	29	relative	relative	JJ
cord-306414-2dv3qced	174	30	to	to	IN
cord-306414-2dv3qced	174	31	other	other	JJ
cord-306414-2dv3qced	174	32	biological	biological	JJ
cord-306414-2dv3qced	174	33	materials	material	NNS
cord-306414-2dv3qced	174	34	,	,	,
cord-306414-2dv3qced	174	35	is	be	VBZ
cord-306414-2dv3qced	174	36	low	low	JJ
cord-306414-2dv3qced	174	37	[	[	-LRB-
cord-306414-2dv3qced	174	38	68	68	CD
cord-306414-2dv3qced	174	39	]	]	-RRB-
cord-306414-2dv3qced	174	40	.	.	.
cord-306414-2dv3qced	175	1	Bronchoalveolar	Bronchoalveolar	NNP
cord-306414-2dv3qced	175	2	lavage	lavage	NN
cord-306414-2dv3qced	175	3	and	and	CC
cord-306414-2dv3qced	175	4	lung	lung	NN
cord-306414-2dv3qced	175	5	tissue	tissue	NN
cord-306414-2dv3qced	175	6	samples	sample	NNS
cord-306414-2dv3qced	175	7	may	may	MD
cord-306414-2dv3qced	175	8	be	be	VB
cord-306414-2dv3qced	175	9	an	an	DT
cord-306414-2dv3qced	175	10	attractive	attractive	JJ
cord-306414-2dv3qced	175	11	and	and	CC
cord-306414-2dv3qced	175	12	informative	informative	JJ
cord-306414-2dv3qced	175	13	choice	choice	NN
cord-306414-2dv3qced	175	14	but	but	CC
cord-306414-2dv3qced	175	15	acquiring	acquire	VBG
cord-306414-2dv3qced	175	16	such	such	JJ
cord-306414-2dv3qced	175	17	samples	sample	NNS
cord-306414-2dv3qced	175	18	is	be	VBZ
cord-306414-2dv3qced	175	19	difficult	difficult	JJ
cord-306414-2dv3qced	175	20	for	for	IN
cord-306414-2dv3qced	175	21	a	a	DT
cord-306414-2dv3qced	175	22	variety	variety	NN
cord-306414-2dv3qced	175	23	of	of	IN
cord-306414-2dv3qced	175	24	reasons	reason	NNS
cord-306414-2dv3qced	175	25	,	,	,
cord-306414-2dv3qced	175	26	particularly	particularly	RB
cord-306414-2dv3qced	175	27	patient	patient	JJ
cord-306414-2dv3qced	175	28	willingness	willingness	NN
cord-306414-2dv3qced	175	29	and	and	CC
cord-306414-2dv3qced	175	30	worker	worker	NN
cord-306414-2dv3qced	175	31	safety	safety	NN
cord-306414-2dv3qced	175	32	[	[	-LRB-
cord-306414-2dv3qced	175	33	69	69	CD
cord-306414-2dv3qced	175	34	]	]	-RRB-
cord-306414-2dv3qced	175	35	.	.	.
cord-306414-2dv3qced	176	1	In	in	IN
cord-306414-2dv3qced	176	2	addition	addition	NN
cord-306414-2dv3qced	176	3	,	,	,
cord-306414-2dv3qced	176	4	these	these	DT
cord-306414-2dv3qced	176	5	procedures	procedure	NNS
cord-306414-2dv3qced	176	6	are	be	VBP
cord-306414-2dv3qced	176	7	invasive	invasive	JJ
cord-306414-2dv3qced	176	8	to	to	TO
cord-306414-2dv3qced	176	9	perform	perform	VB
cord-306414-2dv3qced	176	10	on	on	IN
cord-306414-2dv3qced	176	11	mild	mild	JJ
cord-306414-2dv3qced	176	12	cases	case	NNS
cord-306414-2dv3qced	176	13	and	and	CC
cord-306414-2dv3qced	176	14	otherwise	otherwise	RB
cord-306414-2dv3qced	176	15	healthy	healthy	JJ
cord-306414-2dv3qced	176	16	individuals	individual	NNS
cord-306414-2dv3qced	176	17	for	for	IN
cord-306414-2dv3qced	176	18	research	research	NN
cord-306414-2dv3qced	176	19	purposes	purpose	NNS
cord-306414-2dv3qced	176	20	.	.	.
cord-306414-2dv3qced	177	1	Peripheral	peripheral	JJ
cord-306414-2dv3qced	177	2	blood	blood	NN
cord-306414-2dv3qced	177	3	samples	sample	NNS
cord-306414-2dv3qced	177	4	are	be	VBP
cord-306414-2dv3qced	177	5	easy	easy	JJ
cord-306414-2dv3qced	177	6	to	to	TO
cord-306414-2dv3qced	177	7	collect	collect	VB
cord-306414-2dv3qced	177	8	and	and	CC
cord-306414-2dv3qced	177	9	are	be	VBP
cord-306414-2dv3qced	177	10	the	the	DT
cord-306414-2dv3qced	177	11	most	most	RBS
cord-306414-2dv3qced	177	12	feasible	feasible	JJ
cord-306414-2dv3qced	177	13	,	,	,
cord-306414-2dv3qced	177	14	particularly	particularly	RB
cord-306414-2dv3qced	177	15	to	to	TO
cord-306414-2dv3qced	177	16	examine	examine	VB
cord-306414-2dv3qced	177	17	the	the	DT
cord-306414-2dv3qced	177	18	dynamics	dynamic	NNS
cord-306414-2dv3qced	177	19	of	of	IN
cord-306414-2dv3qced	177	20	the	the	DT
cord-306414-2dv3qced	177	21	TCR	TCR	NNP
cord-306414-2dv3qced	177	22	repertoire	repertoire	NN
cord-306414-2dv3qced	177	23	,	,	,
cord-306414-2dv3qced	177	24	as	as	IN
cord-306414-2dv3qced	177	25	multiple	multiple	JJ
cord-306414-2dv3qced	177	26	collections	collection	NNS
cord-306414-2dv3qced	177	27	could	could	MD
cord-306414-2dv3qced	177	28	be	be	VB
cord-306414-2dv3qced	177	29	performed	perform	VBN
cord-306414-2dv3qced	177	30	,	,	,
cord-306414-2dv3qced	177	31	starting	start	VBG
cord-306414-2dv3qced	177	32	from	from	IN
cord-306414-2dv3qced	177	33	diagnosis	diagnosis	NN
cord-306414-2dv3qced	177	34	and	and	CC
cord-306414-2dv3qced	177	35	respond	respond	VB
cord-306414-2dv3qced	177	36	(	(	-LRB-
cord-306414-2dv3qced	177	37	at	at	IN
cord-306414-2dv3qced	177	38	the	the	DT
cord-306414-2dv3qced	177	39	population	population	NN
cord-306414-2dv3qced	177	40	level	level	NN
cord-306414-2dv3qced	177	41	)	)	-RRB-
cord-306414-2dv3qced	177	42	to	to	IN
cord-306414-2dv3qced	177	43	almost	almost	RB
cord-306414-2dv3qced	177	44	any	any	DT
cord-306414-2dv3qced	177	45	infection	infection	NN
cord-306414-2dv3qced	177	46	.	.	.
cord-306414-2dv3qced	178	1	TCR	TCR	NNP
cord-306414-2dv3qced	178	2	bias	bias	NNP
cord-306414-2dv3qced	178	3	:	:	:
cord-306414-2dv3qced	178	4	refers	refer	VBZ
cord-306414-2dv3qced	178	5	to	to	IN
cord-306414-2dv3qced	178	6	the	the	DT
cord-306414-2dv3qced	178	7	overrepresentation	overrepresentation	NN
cord-306414-2dv3qced	178	8	of	of	IN
cord-306414-2dv3qced	178	9	TCR	TCR	NNP
cord-306414-2dv3qced	178	10	genes	gene	NNS
cord-306414-2dv3qced	178	11	or	or	CC
cord-306414-2dv3qced	178	12	clones	clone	NNS
cord-306414-2dv3qced	178	13	in	in	IN
cord-306414-2dv3qced	178	14	the	the	DT
cord-306414-2dv3qced	178	15	TCR	TCR	NNP
cord-306414-2dv3qced	178	16	repertoire	repertoire	NN
cord-306414-2dv3qced	178	17	.	.	.
cord-306414-2dv3qced	179	1	The	the	DT
cord-306414-2dv3qced	179	2	bias	bias	NN
cord-306414-2dv3qced	179	3	in	in	IN
cord-306414-2dv3qced	179	4	TCR	TCR	NNP
cord-306414-2dv3qced	179	5	usage	usage	NN
cord-306414-2dv3qced	179	6	can	can	MD
cord-306414-2dv3qced	179	7	be	be	VB
cord-306414-2dv3qced	179	8	categorized	categorize	VBN
cord-306414-2dv3qced	179	9	based	base	VBN
cord-306414-2dv3qced	179	10	on	on	IN
cord-306414-2dv3qced	179	11	the	the	DT
cord-306414-2dv3qced	179	12	diversity	diversity	NN
cord-306414-2dv3qced	179	13	in	in	IN
cord-306414-2dv3qced	179	14	a	a	DT
cord-306414-2dv3qced	179	15	specific	specific	JJ
cord-306414-2dv3qced	179	16	T	t	NN
cord-306414-2dv3qced	179	17	cell	cell	NN
cord-306414-2dv3qced	179	18	population	population	NN
cord-306414-2dv3qced	179	19	.	.	.
cord-306414-2dv3qced	180	1	TCR	TCR	NNP
cord-306414-2dv3qced	180	2	bias	bias	NN
cord-306414-2dv3qced	180	3	can	can	MD
cord-306414-2dv3qced	180	4	be	be	VB
cord-306414-2dv3qced	180	5	influenced	influence	VBN
cord-306414-2dv3qced	180	6	by	by	IN
cord-306414-2dv3qced	180	7	many	many	JJ
cord-306414-2dv3qced	180	8	factors	factor	NNS
cord-306414-2dv3qced	180	9	,	,	,
cord-306414-2dv3qced	180	10	such	such	JJ
cord-306414-2dv3qced	180	11	as	as	IN
cord-306414-2dv3qced	180	12	thymic	thymic	JJ
cord-306414-2dv3qced	180	13	selection	selection	NN
cord-306414-2dv3qced	180	14	and	and	CC
cord-306414-2dv3qced	180	15	antigen	antigen	NN
cord-306414-2dv3qced	180	16	-	-	HYPH
cord-306414-2dv3qced	180	17	driven	drive	VBN
cord-306414-2dv3qced	180	18	selection	selection	NN
cord-306414-2dv3qced	180	19	,	,	,
cord-306414-2dv3qced	180	20	which	which	WDT
cord-306414-2dv3qced	180	21	can	can	MD
cord-306414-2dv3qced	180	22	narrow	narrow	VB
cord-306414-2dv3qced	180	23	the	the	DT
cord-306414-2dv3qced	180	24	available	available	JJ
cord-306414-2dv3qced	180	25	T	T	NNP
cord-306414-2dv3qced	180	26	cell	cell	NN
cord-306414-2dv3qced	180	27	repertoire	repertoire	NN
cord-306414-2dv3qced	180	28	over	over	IN
cord-306414-2dv3qced	180	29	time	time	NN
cord-306414-2dv3qced	180	30	.	.	.
cord-306414-2dv3qced	181	1	TCR	TCR	NNP
cord-306414-2dv3qced	181	2	engineered	engineer	VBD
cord-306414-2dv3qced	181	3	T	t	NN
cord-306414-2dv3qced	181	4	cell	cell	NN
cord-306414-2dv3qced	181	5	(	(	-LRB-
cord-306414-2dv3qced	181	6	TCR	TCR	NNP
cord-306414-2dv3qced	181	7	-	-	HYPH
cord-306414-2dv3qced	181	8	T	T	NNP
cord-306414-2dv3qced	181	9	)	)	-RRB-
cord-306414-2dv3qced	181	10	:	:	:
cord-306414-2dv3qced	182	1	T	t	NN
cord-306414-2dv3qced	182	2	cells	cell	NNS
cord-306414-2dv3qced	182	3	engineered	engineer	VBN
cord-306414-2dv3qced	182	4	by	by	IN
cord-306414-2dv3qced	182	5	viral	viral	JJ
cord-306414-2dv3qced	182	6	vectors	vector	NNS
cord-306414-2dv3qced	182	7	to	to	TO
cord-306414-2dv3qced	182	8	express	express	VB
cord-306414-2dv3qced	182	9	the	the	DT
cord-306414-2dv3qced	182	10	TCR	TCR	NNP
cord-306414-2dv3qced	182	11	gene	gene	NN
cord-306414-2dv3qced	182	12	with	with	IN
cord-306414-2dv3qced	182	13	defined	define	VBN
cord-306414-2dv3qced	182	14	specificity	specificity	NN
cord-306414-2dv3qced	182	15	.	.	.
cord-306414-2dv3qced	183	1	These	these	DT
cord-306414-2dv3qced	183	2	cells	cell	NNS
cord-306414-2dv3qced	183	3	can	can	MD
cord-306414-2dv3qced	183	4	be	be	VB
cord-306414-2dv3qced	183	5	modified	modify	VBN
cord-306414-2dv3qced	183	6	to	to	TO
cord-306414-2dv3qced	183	7	target	target	VB
cord-306414-2dv3qced	183	8	cancer	cancer	NN
cord-306414-2dv3qced	183	9	cells	cell	NNS
cord-306414-2dv3qced	183	10	or	or	CC
cord-306414-2dv3qced	183	11	bacterial	bacterial	JJ
cord-306414-2dv3qced	183	12	/	/	SYM
cord-306414-2dv3qced	183	13	virusinfected	virusinfecte	VBN
cord-306414-2dv3qced	183	14	cells	cell	NNS
cord-306414-2dv3qced	183	15	.	.	.
cord-306414-2dv3qced	184	1	TCR	TCR	NNP
cord-306414-2dv3qced	184	2	repertoire	repertoire	NN
cord-306414-2dv3qced	184	3	:	:	:
cord-306414-2dv3qced	185	1	the	the	DT
cord-306414-2dv3qced	185	2	sum	sum	NN
cord-306414-2dv3qced	185	3	of	of	IN
cord-306414-2dv3qced	185	4	all	all	DT
cord-306414-2dv3qced	185	5	TCRs	tcr	NNS
cord-306414-2dv3qced	185	6	by	by	IN
cord-306414-2dv3qced	185	7	the	the	DT
cord-306414-2dv3qced	185	8	T	T	NNP
cord-306414-2dv3qced	185	9	cells	cell	NNS
cord-306414-2dv3qced	185	10	of	of	IN
cord-306414-2dv3qced	185	11	one	one	CD
cord-306414-2dv3qced	185	12	individual	individual	NN
cord-306414-2dv3qced	185	13	generated	generate	VBN
cord-306414-2dv3qced	185	14	by	by	IN
cord-306414-2dv3qced	185	15	somatic	somatic	JJ
cord-306414-2dv3qced	185	16	DNA	dna	NN
cord-306414-2dv3qced	185	17	rearrangements	rearrangement	NNS
cord-306414-2dv3qced	185	18	.	.	.
cord-306414-2dv3qced	186	1	TCR	TCR	NNP
cord-306414-2dv3qced	186	2	sequencing	sequencing	NNP
cord-306414-2dv3qced	186	3	(	(	-LRB-
cord-306414-2dv3qced	186	4	TCR	TCR	NNP
cord-306414-2dv3qced	186	5	-	-	HYPH
cord-306414-2dv3qced	186	6	seq	seq	NNP
cord-306414-2dv3qced	186	7	)	)	-RRB-
cord-306414-2dv3qced	186	8	:	:	:
cord-306414-2dv3qced	187	1	highthroughput	highthroughput	NN
cord-306414-2dv3qced	187	2	sequencing	sequencing	NN
cord-306414-2dv3qced	187	3	technologies	technology	NNS
cord-306414-2dv3qced	187	4	used	use	VBN
cord-306414-2dv3qced	187	5	in	in	IN
cord-306414-2dv3qced	187	6	the	the	DT
cord-306414-2dv3qced	187	7	examination	examination	NN
cord-306414-2dv3qced	187	8	of	of	IN
cord-306414-2dv3qced	187	9	antigen	antigen	NN
cord-306414-2dv3qced	187	10	receptor	receptor	NN
cord-306414-2dv3qced	187	11	repertoires	repertoire	NNS
cord-306414-2dv3qced	187	12	at	at	IN
cord-306414-2dv3qced	187	13	single	single	JJ
cord-306414-2dv3qced	187	14	-	-	HYPH
cord-306414-2dv3qced	187	15	nucleotide	nucleotide	NN
cord-306414-2dv3qced	187	16	and	and	CC
cord-306414-2dv3qced	187	17	,	,	,
cord-306414-2dv3qced	187	18	more	more	RBR
cord-306414-2dv3qced	187	19	recently	recently	RB
cord-306414-2dv3qced	187	20	,	,	,
cord-306414-2dv3qced	187	21	single	single	JJ
cord-306414-2dv3qced	187	22	-	-	HYPH
cord-306414-2dv3qced	187	23	cell	cell	NN
cord-306414-2dv3qced	187	24	resolution	resolution	NN
cord-306414-2dv3qced	187	25	.	.	.
cord-306414-2dv3qced	188	1	Thymopoiesis	thymopoiesis	NN
cord-306414-2dv3qced	188	2	:	:	:
cord-306414-2dv3qced	188	3	process	process	NN
cord-306414-2dv3qced	188	4	that	that	WDT
cord-306414-2dv3qced	188	5	turns	turn	VBZ
cord-306414-2dv3qced	188	6	thymocytes	thymocyte	NNS
cord-306414-2dv3qced	188	7	into	into	IN
cord-306414-2dv3qced	188	8	mature	mature	JJ
cord-306414-2dv3qced	188	9	T	t	NN
cord-306414-2dv3qced	188	10	cells	cell	NNS
cord-306414-2dv3qced	188	11	according	accord	VBG
cord-306414-2dv3qced	188	12	to	to	IN
cord-306414-2dv3qced	188	13	selection	selection	NN
cord-306414-2dv3qced	188	14	processes	process	NNS
cord-306414-2dv3qced	188	15	.	.	.
cord-306414-2dv3qced	189	1	This	this	DT
cord-306414-2dv3qced	189	2	selection	selection	NN
cord-306414-2dv3qced	189	3	process	process	NN
cord-306414-2dv3qced	189	4	is	be	VBZ
cord-306414-2dv3qced	189	5	vitally	vitally	RB
cord-306414-2dv3qced	189	6	important	important	JJ
cord-306414-2dv3qced	189	7	in	in	IN
cord-306414-2dv3qced	189	8	shaping	shape	VBG
cord-306414-2dv3qced	189	9	the	the	DT
cord-306414-2dv3qced	189	10	population	population	NN
cord-306414-2dv3qced	189	11	of	of	IN
cord-306414-2dv3qced	189	12	thymocytes	thymocyte	NNS
cord-306414-2dv3qced	189	13	into	into	IN
cord-306414-2dv3qced	189	14	a	a	DT
cord-306414-2dv3qced	189	15	peripheral	peripheral	JJ
cord-306414-2dv3qced	189	16	pool	pool	NN
cord-306414-2dv3qced	189	17	of	of	IN
cord-306414-2dv3qced	189	18	T	t	NN
cord-306414-2dv3qced	189	19	cells	cell	NNS
cord-306414-2dv3qced	189	20	that	that	WDT
cord-306414-2dv3qced	189	21	are	be	VBP
cord-306414-2dv3qced	189	22	able	able	JJ
cord-306414-2dv3qced	189	23	to	to	TO
cord-306414-2dv3qced	189	24	respond	respond	VB
cord-306414-2dv3qced	189	25	to	to	IN
cord-306414-2dv3qced	189	26	foreign	foreign	JJ
cord-306414-2dv3qced	189	27	pathogens	pathogen	NNS
cord-306414-2dv3qced	189	28	but	but	CC
cord-306414-2dv3qced	189	29	remain	remain	VBP
cord-306414-2dv3qced	189	30	tolerant	tolerant	JJ
cord-306414-2dv3qced	189	31	towards	towards	IN
cord-306414-2dv3qced	189	32	the	the	DT
cord-306414-2dv3qced	189	33	body	body	NN
cord-306414-2dv3qced	189	34	's	's	POS
cord-306414-2dv3qced	189	35	own	own	JJ
cord-306414-2dv3qced	189	36	antigens	antigen	NNS
cord-306414-2dv3qced	189	37	.	.	.
cord-306414-2dv3qced	190	1	V(D)J	V(D)J	NNP
cord-306414-2dv3qced	190	2	recombination	recombination	NN
cord-306414-2dv3qced	190	3	:	:	:
cord-306414-2dv3qced	190	4	the	the	DT
cord-306414-2dv3qced	190	5	process	process	NN
cord-306414-2dv3qced	190	6	by	by	IN
cord-306414-2dv3qced	190	7	which	which	WDT
cord-306414-2dv3qced	190	8	T	t	NN
cord-306414-2dv3qced	190	9	cells	cell	NNS
cord-306414-2dv3qced	190	10	randomly	randomly	RB
cord-306414-2dv3qced	190	11	assemble	assemble	VBP
cord-306414-2dv3qced	190	12	different	different	JJ
cord-306414-2dv3qced	190	13	gene	gene	NN
cord-306414-2dv3qced	190	14	segments	segment	NNS
cord-306414-2dv3qced	190	15	,	,	,
cord-306414-2dv3qced	190	16	known	know	VBN
cord-306414-2dv3qced	190	17	as	as	IN
cord-306414-2dv3qced	190	18	variable	variable	NN
cord-306414-2dv3qced	190	19	(	(	-LRB-
cord-306414-2dv3qced	190	20	V	v	NN
cord-306414-2dv3qced	190	21	)	)	-RRB-
cord-306414-2dv3qced	190	22	,	,	,
cord-306414-2dv3qced	190	23	diversity	diversity	NN
cord-306414-2dv3qced	190	24	(	(	-LRB-
cord-306414-2dv3qced	190	25	D	D	NNP
cord-306414-2dv3qced	190	26	)	)	-RRB-
cord-306414-2dv3qced	190	27	,	,	,
cord-306414-2dv3qced	190	28	and	and	CC
cord-306414-2dv3qced	190	29	joining	join	VBG
cord-306414-2dv3qced	190	30	(	(	-LRB-
cord-306414-2dv3qced	190	31	J	J	NNP
cord-306414-2dv3qced	190	32	)	)	-RRB-
cord-306414-2dv3qced	190	33	genes	gene	NNS
cord-306414-2dv3qced	190	34	,	,	,
cord-306414-2dv3qced	190	35	in	in	IN
cord-306414-2dv3qced	190	36	order	order	NN
cord-306414-2dv3qced	190	37	to	to	TO
cord-306414-2dv3qced	190	38	generate	generate	VB
cord-306414-2dv3qced	190	39	unique	unique	JJ
cord-306414-2dv3qced	190	40	receptors	receptor	NNS
cord-306414-2dv3qced	190	41	(	(	-LRB-
cord-306414-2dv3qced	190	42	known	know	VBN
cord-306414-2dv3qced	190	43	as	as	IN
cord-306414-2dv3qced	190	44	T	t	NN
cord-306414-2dv3qced	190	45	-	-	HYPH
cord-306414-2dv3qced	190	46	cell	cell	NN
cord-306414-2dv3qced	190	47	receptors	receptor	NNS
cord-306414-2dv3qced	190	48	)	)	-RRB-
cord-306414-2dv3qced	190	49	that	that	WDT
cord-306414-2dv3qced	190	50	can	can	MD
cord-306414-2dv3qced	190	51	collectively	collectively	RB
cord-306414-2dv3qced	190	52	recognize	recognize	VB
cord-306414-2dv3qced	190	53	many	many	JJ
cord-306414-2dv3qced	190	54	different	different	JJ
cord-306414-2dv3qced	190	55	types	type	NNS
cord-306414-2dv3qced	190	56	of	of	IN
cord-306414-2dv3qced	190	57	molecule	molecule	NN
cord-306414-2dv3qced	190	58	.	.	.
cord-306414-2dv3qced	191	1	Trends	trend	NNS
cord-306414-2dv3qced	191	2	in	in	IN
cord-306414-2dv3qced	191	3	Pharmacological	Pharmacological	NNP
cord-306414-2dv3qced	191	4	Sciences	Sciences	NNPS
cord-306414-2dv3qced	191	5	,	,	,
cord-306414-2dv3qced	191	6	Month	Month	NNP
cord-306414-2dv3qced	191	7	2020	2020	CD
cord-306414-2dv3qced	191	8	,	,	,
cord-306414-2dv3qced	191	9	Vol	Vol	NNP
cord-306414-2dv3qced	191	10	.	.	.
cord-306414-2dv3qced	192	1	xx	xx	UH
cord-306414-2dv3qced	192	2	,	,	,
cord-306414-2dv3qced	192	3	No	no	UH
cord-306414-2dv3qced	192	4	.	.	.
cord-306414-2dv3qced	193	1	xx	xx	LS
cord-306414-2dv3qced	194	1	5	5	CD
cord-306414-2dv3qced	194	2	Figure	figure	NN
cord-306414-2dv3qced	194	3	1	1	CD
cord-306414-2dv3qced	194	4	.	.	.
cord-306414-2dv3qced	195	1	T	T	NNP
cord-306414-2dv3qced	195	2	Cell	Cell	NNP
cord-306414-2dv3qced	195	3	-	-	HYPH
cord-306414-2dv3qced	195	4	Mediated	mediate	VBN
cord-306414-2dv3qced	195	5	Response	response	NN
cord-306414-2dv3qced	195	6	to	to	IN
cord-306414-2dv3qced	195	7	Severe	severe	JJ
cord-306414-2dv3qced	195	8	Acute	acute	JJ
cord-306414-2dv3qced	195	9	Respiratory	Respiratory	NNP
cord-306414-2dv3qced	195	10	Syndrome	Syndrome	NNP
cord-306414-2dv3qced	195	11	Coronavirus	Coronavirus	NNP
cord-306414-2dv3qced	195	12	2	2	CD
cord-306414-2dv3qced	196	1	(	(	-LRB-
cord-306414-2dv3qced	196	2	SARS	SARS	NNP
cord-306414-2dv3qced	196	3	-	-	HYPH
cord-306414-2dv3qced	196	4	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	196	5	)	)	-RRB-
cord-306414-2dv3qced	196	6	Infection	infection	NN
cord-306414-2dv3qced	196	7	.	.	.
cord-306414-2dv3qced	197	1	Infection	infection	NN
cord-306414-2dv3qced	197	2	occurs	occur	VBZ
cord-306414-2dv3qced	197	3	in	in	IN
cord-306414-2dv3qced	197	4	the	the	DT
cord-306414-2dv3qced	197	5	patients	patient	NNS
cord-306414-2dv3qced	197	6	after	after	IN
cord-306414-2dv3qced	197	7	respiratory	respiratory	JJ
cord-306414-2dv3qced	197	8	tract	tract	NN
cord-306414-2dv3qced	197	9	exposure	exposure	NN
cord-306414-2dv3qced	197	10	.	.	.
cord-306414-2dv3qced	198	1	Subsequently	subsequently	RB
cord-306414-2dv3qced	198	2	,	,	,
cord-306414-2dv3qced	198	3	virus	virus	NN
cord-306414-2dv3qced	198	4	entry	entry	NN
cord-306414-2dv3qced	198	5	occurs	occur	VBZ
cord-306414-2dv3qced	198	6	via	via	IN
cord-306414-2dv3qced	198	7	binding	bind	VBG
cord-306414-2dv3qced	198	8	to	to	IN
cord-306414-2dv3qced	198	9	angiotensin	angiotensin	NN
cord-306414-2dv3qced	198	10	-	-	HYPH
cord-306414-2dv3qced	198	11	converting	convert	VBG
cord-306414-2dv3qced	198	12	enzyme	enzyme	NN
cord-306414-2dv3qced	198	13	2	2	CD
cord-306414-2dv3qced	198	14	(	(	-LRB-
cord-306414-2dv3qced	198	15	ACE2	ACE2	NNP
cord-306414-2dv3qced	198	16	)	)	-RRB-
cord-306414-2dv3qced	198	17	on	on	IN
cord-306414-2dv3qced	198	18	the	the	DT
cord-306414-2dv3qced	198	19	surface	surface	NN
cord-306414-2dv3qced	198	20	of	of	IN
cord-306414-2dv3qced	198	21	various	various	JJ
cord-306414-2dv3qced	198	22	cell	cell	NN
cord-306414-2dv3qced	198	23	types	type	NNS
cord-306414-2dv3qced	198	24	and	and	CC
cord-306414-2dv3qced	198	25	begins	begin	VBZ
cord-306414-2dv3qced	198	26	viral	viral	JJ
cord-306414-2dv3qced	198	27	replication	replication	NN
cord-306414-2dv3qced	198	28	.	.	.
cord-306414-2dv3qced	199	1	Antigen	antigen	NN
cord-306414-2dv3qced	199	2	-	-	HYPH
cord-306414-2dv3qced	199	3	presenting	present	VBG
cord-306414-2dv3qced	199	4	cells	cell	NNS
cord-306414-2dv3qced	199	5	such	such	JJ
cord-306414-2dv3qced	199	6	as	as	IN
cord-306414-2dv3qced	199	7	dendritic	dendritic	JJ
cord-306414-2dv3qced	199	8	cells	cell	NNS
cord-306414-2dv3qced	199	9	endocytose	endocytose	VBP
cord-306414-2dv3qced	199	10	the	the	DT
cord-306414-2dv3qced	199	11	SARS	SARS	NNP
cord-306414-2dv3qced	199	12	-	-	HYPH
cord-306414-2dv3qced	199	13	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	199	14	virus	virus	NN
cord-306414-2dv3qced	199	15	and	and	CC
cord-306414-2dv3qced	199	16	degrade	degrade	VB
cord-306414-2dv3qced	199	17	them	-PRON-	PRP
cord-306414-2dv3qced	199	18	through	through	IN
cord-306414-2dv3qced	199	19	a	a	DT
cord-306414-2dv3qced	199	20	process	process	NN
cord-306414-2dv3qced	199	21	called	call	VBN
cord-306414-2dv3qced	199	22	antigen	antigen	NN
cord-306414-2dv3qced	199	23	processing	processing	NN
cord-306414-2dv3qced	199	24	.	.	.
cord-306414-2dv3qced	200	1	These	these	DT
cord-306414-2dv3qced	200	2	antigen	antigen	NN
cord-306414-2dv3qced	200	3	fragments	fragment	NNS
cord-306414-2dv3qced	200	4	are	be	VBP
cord-306414-2dv3qced	200	5	then	then	RB
cord-306414-2dv3qced	200	6	presented	present	VBN
cord-306414-2dv3qced	200	7	by	by	IN
cord-306414-2dv3qced	200	8	proteins	protein	NNS
cord-306414-2dv3qced	200	9	termed	term	VBN
cord-306414-2dv3qced	200	10	'	'	``
cord-306414-2dv3qced	200	11	MHC	MHC	NNP
cord-306414-2dv3qced	200	12	class	class	NN
cord-306414-2dv3qced	200	13	molecules	molecule	NNS
cord-306414-2dv3qced	200	14	'	'	''
cord-306414-2dv3qced	200	15	,	,	,
cord-306414-2dv3qced	200	16	on	on	IN
cord-306414-2dv3qced	200	17	the	the	DT
cord-306414-2dv3qced	200	18	cell	cell	NN
cord-306414-2dv3qced	200	19	surface	surface	NN
cord-306414-2dv3qced	200	20	and	and	CC
cord-306414-2dv3qced	200	21	allow	allow	VB
cord-306414-2dv3qced	200	22	recognition	recognition	NN
cord-306414-2dv3qced	200	23	by	by	IN
cord-306414-2dv3qced	200	24	a	a	DT
cord-306414-2dv3qced	200	25	T	T	NNP
cord-306414-2dv3qced	200	26	cell	cell	NN
cord-306414-2dv3qced	200	27	.	.	.
cord-306414-2dv3qced	201	1	If	if	IN
cord-306414-2dv3qced	201	2	a	a	DT
cord-306414-2dv3qced	201	3	CD8	CD8	NNP
cord-306414-2dv3qced	201	4	+	+	CC
cord-306414-2dv3qced	201	5	T	t	NN
cord-306414-2dv3qced	201	6	cell	cell	NN
cord-306414-2dv3qced	201	7	is	be	VBZ
cord-306414-2dv3qced	201	8	capable	capable	JJ
cord-306414-2dv3qced	201	9	of	of	IN
cord-306414-2dv3qced	201	10	binding	bind	VBG
cord-306414-2dv3qced	201	11	,	,	,
cord-306414-2dv3qced	201	12	it	-PRON-	PRP
cord-306414-2dv3qced	201	13	will	will	MD
cord-306414-2dv3qced	201	14	undergo	undergo	VB
cord-306414-2dv3qced	201	15	clonal	clonal	JJ
cord-306414-2dv3qced	201	16	expansion	expansion	NN
cord-306414-2dv3qced	201	17	and	and	CC
cord-306414-2dv3qced	201	18	directly	directly	RB
cord-306414-2dv3qced	201	19	target	target	VB
cord-306414-2dv3qced	201	20	infected	infected	JJ
cord-306414-2dv3qced	201	21	cells	cell	NNS
cord-306414-2dv3qced	201	22	through	through	IN
cord-306414-2dv3qced	201	23	either	either	DT
cord-306414-2dv3qced	201	24	perforin	perforin	NNP
cord-306414-2dv3qced	201	25	/	/	SYM
cord-306414-2dv3qced	201	26	granzymes	granzyme	NNS
cord-306414-2dv3qced	201	27	,	,	,
cord-306414-2dv3qced	201	28	FAS	FAS	NNP
cord-306414-2dv3qced	201	29	ligand	ligand	NN
cord-306414-2dv3qced	201	30	/	/	SYM
cord-306414-2dv3qced	201	31	tumor	tumor	NN
cord-306414-2dv3qced	201	32	necrosis	necrosis	NN
cord-306414-2dv3qced	201	33	factor	factor	NN
cord-306414-2dv3qced	201	34	-	-	HYPH
cord-306414-2dv3qced	201	35	related	relate	VBN
cord-306414-2dv3qced	201	36	apoptosisinducing	apoptosisinducing	NN
cord-306414-2dv3qced	201	37	ligand	ligand	NN
cord-306414-2dv3qced	201	38	(	(	-LRB-
cord-306414-2dv3qced	201	39	TRAIL	TRAIL	NNP
cord-306414-2dv3qced	201	40	)	)	-RRB-
cord-306414-2dv3qced	201	41	pathways	pathway	NNS
cord-306414-2dv3qced	201	42	,	,	,
cord-306414-2dv3qced	201	43	or	or	CC
cord-306414-2dv3qced	201	44	secretion	secretion	NN
cord-306414-2dv3qced	201	45	of	of	IN
cord-306414-2dv3qced	201	46	proinflammatory	proinflammatory	JJ
cord-306414-2dv3qced	201	47	mediators	mediator	NNS
cord-306414-2dv3qced	201	48	.	.	.
cord-306414-2dv3qced	202	1	If	if	IN
cord-306414-2dv3qced	202	2	the	the	DT
cord-306414-2dv3qced	202	3	CD4	CD4	NNP
cord-306414-2dv3qced	202	4	+	+	CC
cord-306414-2dv3qced	202	5	T	T	NNP
cord-306414-2dv3qced	202	6	cell	cell	NN
cord-306414-2dv3qced	202	7	is	be	VBZ
cord-306414-2dv3qced	202	8	capable	capable	JJ
cord-306414-2dv3qced	202	9	of	of	IN
cord-306414-2dv3qced	202	10	binding	bind	VBG
cord-306414-2dv3qced	202	11	,	,	,
cord-306414-2dv3qced	202	12	it	-PRON-	PRP
cord-306414-2dv3qced	202	13	can	can	MD
cord-306414-2dv3qced	202	14	activate	activate	VB
cord-306414-2dv3qced	202	15	B	b	NN
cord-306414-2dv3qced	202	16	cells	cell	NNS
cord-306414-2dv3qced	202	17	that	that	WDT
cord-306414-2dv3qced	202	18	recognize	recognize	VBP
cord-306414-2dv3qced	202	19	the	the	DT
cord-306414-2dv3qced	202	20	antigen	antigen	NN
cord-306414-2dv3qced	202	21	by	by	IN
cord-306414-2dv3qced	202	22	causing	cause	VBG
cord-306414-2dv3qced	202	23	them	-PRON-	PRP
cord-306414-2dv3qced	202	24	to	to	TO
cord-306414-2dv3qced	202	25	clonally	clonally	RB
cord-306414-2dv3qced	202	26	proliferate	proliferate	VB
cord-306414-2dv3qced	202	27	and	and	CC
cord-306414-2dv3qced	202	28	secrete	secrete	VB
cord-306414-2dv3qced	202	29	antibodies	antibody	NNS
cord-306414-2dv3qced	202	30	to	to	TO
cord-306414-2dv3qced	202	31	target	target	VB
cord-306414-2dv3qced	202	32	the	the	DT
cord-306414-2dv3qced	202	33	SARS	SARS	NNP
cord-306414-2dv3qced	202	34	-	-	HYPH
cord-306414-2dv3qced	202	35	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	202	36	virus	virus	NN
cord-306414-2dv3qced	202	37	.	.	.
cord-306414-2dv3qced	203	1	Abbreviations	abbreviation	NNS
cord-306414-2dv3qced	203	2	:	:	:
cord-306414-2dv3qced	203	3	BCR	BCR	NNP
cord-306414-2dv3qced	203	4	,	,	,
cord-306414-2dv3qced	203	5	B	b	NN
cord-306414-2dv3qced	203	6	cell	cell	NN
cord-306414-2dv3qced	203	7	receptor	receptor	NN
cord-306414-2dv3qced	203	8	;	;	:
cord-306414-2dv3qced	203	9	MHC	MHC	NNP
cord-306414-2dv3qced	203	10	,	,	,
cord-306414-2dv3qced	203	11	major	major	JJ
cord-306414-2dv3qced	203	12	histocompatibility	histocompatibility	NN
cord-306414-2dv3qced	203	13	complex	complex	NN
cord-306414-2dv3qced	203	14	;	;	:
cord-306414-2dv3qced	203	15	TCR	TCR	NNP
cord-306414-2dv3qced	203	16	,	,	,
cord-306414-2dv3qced	203	17	T	T	NNP
cord-306414-2dv3qced	203	18	cell	cell	NN
cord-306414-2dv3qced	203	19	receptor	receptor	NN
cord-306414-2dv3qced	203	20	.	.	.
cord-306414-2dv3qced	204	1	then	then	RB
cord-306414-2dv3qced	204	2	weekly	weekly	RB
cord-306414-2dv3qced	204	3	till	till	IN
cord-306414-2dv3qced	204	4	recovery	recovery	NN
cord-306414-2dv3qced	204	5	or	or	CC
cord-306414-2dv3qced	204	6	even	even	RB
cord-306414-2dv3qced	204	7	afterward	afterward	RB
cord-306414-2dv3qced	204	8	to	to	TO
cord-306414-2dv3qced	204	9	track	track	VB
cord-306414-2dv3qced	204	10	memory	memory	NN
cord-306414-2dv3qced	204	11	T	T	NNP
cord-306414-2dv3qced	204	12	cell	cell	NN
cord-306414-2dv3qced	204	13	clones	clone	NNS
cord-306414-2dv3qced	204	14	.	.	.
cord-306414-2dv3qced	205	1	SARS	SARS	NNP
cord-306414-2dv3qced	205	2	-	-	HYPH
cord-306414-2dv3qced	205	3	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	205	4	reactive	reactive	JJ
cord-306414-2dv3qced	205	5	T	t	NN
cord-306414-2dv3qced	205	6	cells	cell	NNS
cord-306414-2dv3qced	205	7	would	would	MD
cord-306414-2dv3qced	205	8	transiently	transiently	RB
cord-306414-2dv3qced	205	9	appear	appear	VB
cord-306414-2dv3qced	205	10	/	/	SYM
cord-306414-2dv3qced	205	11	persist	persist	VBP
cord-306414-2dv3qced	205	12	in	in	IN
cord-306414-2dv3qced	205	13	blood	blood	NN
cord-306414-2dv3qced	205	14	as	as	IN
cord-306414-2dv3qced	205	15	they	-PRON-	PRP
cord-306414-2dv3qced	205	16	migrate	migrate	VBP
cord-306414-2dv3qced	205	17	from	from	IN
cord-306414-2dv3qced	205	18	lymph	lymph	NN
cord-306414-2dv3qced	205	19	nodes	node	NNS
cord-306414-2dv3qced	205	20	to	to	IN
cord-306414-2dv3qced	205	21	tissue	tissue	VB
cord-306414-2dv3qced	205	22	sites	site	NNS
cord-306414-2dv3qced	205	23	via	via	IN
cord-306414-2dv3qced	205	24	peripheral	peripheral	JJ
cord-306414-2dv3qced	205	25	blood	blood	NN
cord-306414-2dv3qced	205	26	circulation	circulation	NN
cord-306414-2dv3qced	205	27	and	and	CC
cord-306414-2dv3qced	205	28	thus	thus	RB
cord-306414-2dv3qced	205	29	could	could	MD
cord-306414-2dv3qced	205	30	be	be	VB
cord-306414-2dv3qced	205	31	captured	capture	VBN
cord-306414-2dv3qced	205	32	in	in	IN
cord-306414-2dv3qced	205	33	peripheral	peripheral	JJ
cord-306414-2dv3qced	205	34	blood	blood	NN
cord-306414-2dv3qced	205	35	samples	sample	NNS
cord-306414-2dv3qced	205	36	.	.	.
cord-306414-2dv3qced	206	1	However	however	RB
cord-306414-2dv3qced	206	2	,	,	,
cord-306414-2dv3qced	206	3	it	-PRON-	PRP
cord-306414-2dv3qced	206	4	is	be	VBZ
cord-306414-2dv3qced	206	5	possible	possible	JJ
cord-306414-2dv3qced	206	6	that	that	IN
cord-306414-2dv3qced	206	7	their	-PRON-	PRP$
cord-306414-2dv3qced	206	8	frequency	frequency	NN
cord-306414-2dv3qced	206	9	in	in	IN
cord-306414-2dv3qced	206	10	the	the	DT
cord-306414-2dv3qced	206	11	blood	blood	NN
cord-306414-2dv3qced	206	12	may	may	MD
cord-306414-2dv3qced	206	13	be	be	VB
cord-306414-2dv3qced	206	14	low	low	JJ
cord-306414-2dv3qced	206	15	.	.	.
cord-306414-2dv3qced	207	1	It	-PRON-	PRP
cord-306414-2dv3qced	207	2	is	be	VBZ
cord-306414-2dv3qced	207	3	also	also	RB
cord-306414-2dv3qced	207	4	possible	possible	JJ
cord-306414-2dv3qced	207	5	that	that	IN
cord-306414-2dv3qced	207	6	the	the	DT
cord-306414-2dv3qced	207	7	lymphocytopenia	lymphocytopenia	NNP
cord-306414-2dv3qced	207	8	observed	observe	VBN
cord-306414-2dv3qced	207	9	in	in	IN
cord-306414-2dv3qced	207	10	COVID-19	COVID-19	NNP
cord-306414-2dv3qced	207	11	patients	patient	NNS
cord-306414-2dv3qced	207	12	(	(	-LRB-
cord-306414-2dv3qced	207	13	particularly	particularly	RB
cord-306414-2dv3qced	207	14	in	in	IN
cord-306414-2dv3qced	207	15	severe	severe	JJ
cord-306414-2dv3qced	207	16	cases	case	NNS
cord-306414-2dv3qced	207	17	)	)	-RRB-
cord-306414-2dv3qced	207	18	could	could	MD
cord-306414-2dv3qced	207	19	require	require	VB
cord-306414-2dv3qced	207	20	a	a	DT
cord-306414-2dv3qced	207	21	larger	large	JJR
cord-306414-2dv3qced	207	22	volume	volume	NN
cord-306414-2dv3qced	207	23	of	of	IN
cord-306414-2dv3qced	207	24	blood	blood	NN
cord-306414-2dv3qced	207	25	to	to	TO
cord-306414-2dv3qced	207	26	obtain	obtain	VB
cord-306414-2dv3qced	207	27	a	a	DT
cord-306414-2dv3qced	207	28	sufficient	sufficient	JJ
cord-306414-2dv3qced	207	29	number	number	NN
cord-306414-2dv3qced	207	30	of	of	IN
cord-306414-2dv3qced	207	31	T	t	NN
cord-306414-2dv3qced	207	32	cells	cell	NNS
cord-306414-2dv3qced	207	33	for	for	IN
cord-306414-2dv3qced	207	34	comprehensive	comprehensive	JJ
cord-306414-2dv3qced	207	35	TCR	TCR	NNP
cord-306414-2dv3qced	207	36	repertoire	repertoire	NN
cord-306414-2dv3qced	207	37	profiling	profiling	NN
cord-306414-2dv3qced	207	38	.	.	.
cord-306414-2dv3qced	208	1	Another	another	DT
cord-306414-2dv3qced	208	2	drawback	drawback	NN
cord-306414-2dv3qced	208	3	to	to	IN
cord-306414-2dv3qced	208	4	using	use	VBG
cord-306414-2dv3qced	208	5	peripheral	peripheral	JJ
cord-306414-2dv3qced	208	6	blood	blood	NN
cord-306414-2dv3qced	208	7	samples	sample	NNS
cord-306414-2dv3qced	208	8	is	be	VBZ
cord-306414-2dv3qced	208	9	that	that	IN
cord-306414-2dv3qced	208	10	they	-PRON-	PRP
cord-306414-2dv3qced	208	11	would	would	MD
cord-306414-2dv3qced	208	12	not	not	RB
cord-306414-2dv3qced	208	13	capture	capture	VB
cord-306414-2dv3qced	208	14	SARS	SARS	NNP
cord-306414-2dv3qced	208	15	-	-	HYPH
cord-306414-2dv3qced	208	16	CoV-2-specific	CoV-2-specific	NNP
cord-306414-2dv3qced	208	17	T	T	NNP
cord-306414-2dv3qced	208	18	cell	cell	NN
cord-306414-2dv3qced	208	19	expansion	expansion	NN
cord-306414-2dv3qced	208	20	as	as	RB
cord-306414-2dv3qced	208	21	well	well	RB
cord-306414-2dv3qced	208	22	as	as	IN
cord-306414-2dv3qced	208	23	samples	sample	NNS
cord-306414-2dv3qced	208	24	from	from	IN
cord-306414-2dv3qced	208	25	infected	infected	JJ
cord-306414-2dv3qced	208	26	tissues	tissue	NNS
cord-306414-2dv3qced	208	27	such	such	JJ
cord-306414-2dv3qced	208	28	as	as	IN
cord-306414-2dv3qced	208	29	lung	lung	NN
cord-306414-2dv3qced	208	30	samples	sample	NNS
cord-306414-2dv3qced	209	1	would	would	MD
cord-306414-2dv3qced	209	2	,	,	,
cord-306414-2dv3qced	209	3	as	as	IN
cord-306414-2dv3qced	209	4	SARS	SARS	NNP
cord-306414-2dv3qced	209	5	-	-	HYPH
cord-306414-2dv3qced	209	6	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	209	7	T	t	NN
cord-306414-2dv3qced	209	8	cells	cell	NNS
cord-306414-2dv3qced	209	9	would	would	MD
cord-306414-2dv3qced	209	10	transiently	transiently	RB
cord-306414-2dv3qced	209	11	persist	persist	VB
cord-306414-2dv3qced	209	12	in	in	IN
cord-306414-2dv3qced	209	13	peripheral	peripheral	JJ
cord-306414-2dv3qced	209	14	blood	blood	NN
cord-306414-2dv3qced	209	15	circulation	circulation	NN
cord-306414-2dv3qced	209	16	.	.	.
cord-306414-2dv3qced	210	1	Ultimately	ultimately	RB
cord-306414-2dv3qced	210	2	,	,	,
cord-306414-2dv3qced	210	3	sample	sample	NN
cord-306414-2dv3qced	210	4	selection	selection	NN
cord-306414-2dv3qced	210	5	and	and	CC
cord-306414-2dv3qced	210	6	collection	collection	NN
cord-306414-2dv3qced	210	7	schedule	schedule	NN
cord-306414-2dv3qced	210	8	will	will	MD
cord-306414-2dv3qced	210	9	vary	vary	VB
cord-306414-2dv3qced	210	10	based	base	VBN
cord-306414-2dv3qced	210	11	on	on	IN
cord-306414-2dv3qced	210	12	study	study	NN
cord-306414-2dv3qced	210	13	objectives	objective	NNS
cord-306414-2dv3qced	210	14	and	and	CC
cord-306414-2dv3qced	210	15	composed	compose	VBN
cord-306414-2dv3qced	210	16	of	of	IN
cord-306414-2dv3qced	210	17	the	the	DT
cord-306414-2dv3qced	210	18	alpha	alpha	NN
cord-306414-2dv3qced	210	19	(	(	-LRB-
cord-306414-2dv3qced	210	20	α	α	NN
cord-306414-2dv3qced	210	21	)	)	-RRB-
cord-306414-2dv3qced	210	22	and	and	CC
cord-306414-2dv3qced	210	23	beta	beta	NN
cord-306414-2dv3qced	210	24	(	(	-LRB-
cord-306414-2dv3qced	210	25	β	β	NN
cord-306414-2dv3qced	210	26	)	)	-RRB-
cord-306414-2dv3qced	210	27	subunit	subunit	NN
cord-306414-2dv3qced	210	28	.	.	.
cord-306414-2dv3qced	211	1	During	during	IN
cord-306414-2dv3qced	211	2	T	T	NNP
cord-306414-2dv3qced	211	3	cell	cell	NN
cord-306414-2dv3qced	211	4	development	development	NN
cord-306414-2dv3qced	211	5	,	,	,
cord-306414-2dv3qced	211	6	the	the	DT
cord-306414-2dv3qced	211	7	loci	locus	NNS
cord-306414-2dv3qced	211	8	that	that	WDT
cord-306414-2dv3qced	211	9	encode	encode	VBP
cord-306414-2dv3qced	211	10	T	T	NNP
cord-306414-2dv3qced	211	11	cell	cell	NN
cord-306414-2dv3qced	211	12	receptor	receptor	NN
cord-306414-2dv3qced	211	13	α	α	NN
cord-306414-2dv3qced	211	14	and	and	CC
cord-306414-2dv3qced	211	15	β	β	NN
cord-306414-2dv3qced	211	16	-	-	HYPH
cord-306414-2dv3qced	211	17	chains	chain	NNS
cord-306414-2dv3qced	211	18	are	be	VBP
cord-306414-2dv3qced	211	19	rearranged	rearrange	VBN
cord-306414-2dv3qced	211	20	.	.	.
cord-306414-2dv3qced	212	1	Variable	variable	JJ
cord-306414-2dv3qced	212	2	(	(	-LRB-
cord-306414-2dv3qced	212	3	V	v	NN
cord-306414-2dv3qced	212	4	)	)	-RRB-
cord-306414-2dv3qced	212	5	,	,	,
cord-306414-2dv3qced	212	6	diversity	diversity	NN
cord-306414-2dv3qced	212	7	(	(	-LRB-
cord-306414-2dv3qced	212	8	D	D	NNP
cord-306414-2dv3qced	212	9	)	)	-RRB-
cord-306414-2dv3qced	212	10	,	,	,
cord-306414-2dv3qced	212	11	joining	join	VBG
cord-306414-2dv3qced	212	12	(	(	-LRB-
cord-306414-2dv3qced	212	13	J	J	NNP
cord-306414-2dv3qced	212	14	)	)	-RRB-
cord-306414-2dv3qced	212	15	,	,	,
cord-306414-2dv3qced	212	16	and	and	CC
cord-306414-2dv3qced	213	1	constant	constant	JJ
cord-306414-2dv3qced	213	2	(	(	-LRB-
cord-306414-2dv3qced	213	3	C	c	NN
cord-306414-2dv3qced	213	4	)	)	-RRB-
cord-306414-2dv3qced	213	5	gene	gene	NN
cord-306414-2dv3qced	213	6	segments	segment	NNS
cord-306414-2dv3qced	213	7	are	be	VBP
cord-306414-2dv3qced	213	8	represented	represent	VBN
cord-306414-2dv3qced	213	9	as	as	IN
cord-306414-2dv3qced	213	10	blue	blue	JJ
cord-306414-2dv3qced	213	11	,	,	,
cord-306414-2dv3qced	213	12	red	red	JJ
cord-306414-2dv3qced	213	13	,	,	,
cord-306414-2dv3qced	213	14	green	green	JJ
cord-306414-2dv3qced	213	15	,	,	,
cord-306414-2dv3qced	213	16	and	and	CC
cord-306414-2dv3qced	213	17	purple	purple	JJ
cord-306414-2dv3qced	213	18	rectangles	rectangle	NNS
cord-306414-2dv3qced	213	19	,	,	,
cord-306414-2dv3qced	213	20	respectively	respectively	RB
cord-306414-2dv3qced	213	21	.	.	.
cord-306414-2dv3qced	214	1	Diversity	diversity	NN
cord-306414-2dv3qced	214	2	for	for	IN
cord-306414-2dv3qced	214	3	the	the	DT
cord-306414-2dv3qced	214	4	β	β	NNP
cord-306414-2dv3qced	214	5	chain	chain	NN
cord-306414-2dv3qced	214	6	is	be	VBZ
cord-306414-2dv3qced	214	7	first	first	RB
cord-306414-2dv3qced	214	8	created	create	VBN
cord-306414-2dv3qced	214	9	via	via	IN
cord-306414-2dv3qced	214	10	recombination	recombination	NN
cord-306414-2dv3qced	214	11	of	of	IN
cord-306414-2dv3qced	214	12	D	D	NNP
cord-306414-2dv3qced	214	13	and	and	CC
cord-306414-2dv3qced	214	14	J	J	NNP
cord-306414-2dv3qced	214	15	segments	segment	NNS
cord-306414-2dv3qced	214	16	,	,	,
cord-306414-2dv3qced	214	17	followed	follow	VBN
cord-306414-2dv3qced	214	18	by	by	IN
cord-306414-2dv3qced	214	19	the	the	DT
cord-306414-2dv3qced	214	20	V	v	NN
cord-306414-2dv3qced	214	21	segments	segment	NNS
cord-306414-2dv3qced	214	22	,	,	,
cord-306414-2dv3qced	214	23	and	and	CC
cord-306414-2dv3qced	214	24	finally	finally	RB
cord-306414-2dv3qced	214	25	one	one	CD
cord-306414-2dv3qced	214	26	of	of	IN
cord-306414-2dv3qced	214	27	two	two	CD
cord-306414-2dv3qced	214	28	C	c	NN
cord-306414-2dv3qced	214	29	segments	segment	NNS
cord-306414-2dv3qced	214	30	.	.	.
cord-306414-2dv3qced	215	1	Diversity	diversity	NN
cord-306414-2dv3qced	215	2	for	for	IN
cord-306414-2dv3qced	215	3	the	the	DT
cord-306414-2dv3qced	215	4	α	α	NNP
cord-306414-2dv3qced	215	5	chain	chain	NN
cord-306414-2dv3qced	215	6	is	be	VBZ
cord-306414-2dv3qced	215	7	created	create	VBN
cord-306414-2dv3qced	215	8	via	via	IN
cord-306414-2dv3qced	215	9	recombination	recombination	NN
cord-306414-2dv3qced	215	10	of	of	IN
cord-306414-2dv3qced	215	11	V	V	NNP
cord-306414-2dv3qced	215	12	and	and	CC
cord-306414-2dv3qced	215	13	J	J	NNP
cord-306414-2dv3qced	215	14	segments	segment	NNS
cord-306414-2dv3qced	215	15	,	,	,
cord-306414-2dv3qced	215	16	followed	follow	VBN
cord-306414-2dv3qced	215	17	by	by	IN
cord-306414-2dv3qced	215	18	the	the	DT
cord-306414-2dv3qced	215	19	one	one	CD
cord-306414-2dv3qced	215	20	C	c	NN
cord-306414-2dv3qced	215	21	segment	segment	NN
cord-306414-2dv3qced	215	22	.	.	.
cord-306414-2dv3qced	216	1	This	this	DT
cord-306414-2dv3qced	216	2	process	process	NN
cord-306414-2dv3qced	216	3	also	also	RB
cord-306414-2dv3qced	216	4	involves	involve	VBZ
cord-306414-2dv3qced	216	5	the	the	DT
cord-306414-2dv3qced	216	6	deletion	deletion	NN
cord-306414-2dv3qced	216	7	and	and	CC
cord-306414-2dv3qced	216	8	insertion	insertion	NN
cord-306414-2dv3qced	216	9	of	of	IN
cord-306414-2dv3qced	216	10	nucleotides	nucleotide	NNS
cord-306414-2dv3qced	216	11	at	at	IN
cord-306414-2dv3qced	216	12	the	the	DT
cord-306414-2dv3qced	216	13	V	v	NN
cord-306414-2dv3qced	216	14	-	-	HYPH
cord-306414-2dv3qced	216	15	D	D	NNP
cord-306414-2dv3qced	216	16	,	,	,
cord-306414-2dv3qced	216	17	D	D	NNP
cord-306414-2dv3qced	216	18	-	-	HYPH
cord-306414-2dv3qced	216	19	J	J	NNP
cord-306414-2dv3qced	216	20	junctions	junction	NNS
cord-306414-2dv3qced	216	21	for	for	IN
cord-306414-2dv3qced	216	22	the	the	DT
cord-306414-2dv3qced	216	23	β	β	NNP
cord-306414-2dv3qced	216	24	chain	chain	NN
cord-306414-2dv3qced	216	25	and	and	CC
cord-306414-2dv3qced	216	26	V	V	NNP
cord-306414-2dv3qced	216	27	-	-	HYPH
cord-306414-2dv3qced	216	28	J	J	NNP
cord-306414-2dv3qced	216	29	junctions	junction	NNS
cord-306414-2dv3qced	216	30	for	for	IN
cord-306414-2dv3qced	216	31	the	the	DT
cord-306414-2dv3qced	216	32	α	α	NNP
cord-306414-2dv3qced	216	33	chain	chain	NN
cord-306414-2dv3qced	216	34	,	,	,
cord-306414-2dv3qced	216	35	thus	thus	RB
cord-306414-2dv3qced	216	36	adding	add	VBG
cord-306414-2dv3qced	216	37	more	more	JJR
cord-306414-2dv3qced	216	38	potential	potential	JJ
cord-306414-2dv3qced	216	39	diversity	diversity	NN
cord-306414-2dv3qced	216	40	to	to	IN
cord-306414-2dv3qced	216	41	the	the	DT
cord-306414-2dv3qced	216	42	TCR	TCR	NNP
cord-306414-2dv3qced	216	43	repertoire	repertoire	NN
cord-306414-2dv3qced	216	44	.	.	.
cord-306414-2dv3qced	217	1	the	the	DT
cord-306414-2dv3qced	217	2	TCR	TCR	NNP
cord-306414-2dv3qced	217	3	profiling	profiling	NN
cord-306414-2dv3qced	217	4	analysis	analysis	NN
cord-306414-2dv3qced	217	5	platform	platform	NN
cord-306414-2dv3qced	217	6	,	,	,
cord-306414-2dv3qced	217	7	which	which	WDT
cord-306414-2dv3qced	217	8	would	would	MD
cord-306414-2dv3qced	217	9	affect	affect	VB
cord-306414-2dv3qced	217	10	sample	sample	NN
cord-306414-2dv3qced	217	11	collection	collection	NN
cord-306414-2dv3qced	217	12	and	and	CC
cord-306414-2dv3qced	217	13	storage	storage	NN
cord-306414-2dv3qced	217	14	(	(	-LRB-
cord-306414-2dv3qced	217	15	cells	cell	NNS
cord-306414-2dv3qced	217	16	,	,	,
cord-306414-2dv3qced	217	17	RNA	RNA	NNP
cord-306414-2dv3qced	217	18	,	,	,
cord-306414-2dv3qced	217	19	or	or	CC
cord-306414-2dv3qced	217	20	DNA	DNA	NNP
cord-306414-2dv3qced	217	21	)	)	-RRB-
cord-306414-2dv3qced	217	22	.	.	.
cord-306414-2dv3qced	218	1	Sequencing	Sequencing	NNP
cord-306414-2dv3qced	218	2	Platforms	Platforms	NNPS
cord-306414-2dv3qced	218	3	Efforts	effort	NNS
cord-306414-2dv3qced	218	4	to	to	TO
cord-306414-2dv3qced	218	5	characterize	characterize	VB
cord-306414-2dv3qced	218	6	the	the	DT
cord-306414-2dv3qced	218	7	TCR	TCR	NNP
cord-306414-2dv3qced	218	8	repertoire	repertoire	NN
cord-306414-2dv3qced	218	9	in	in	IN
cord-306414-2dv3qced	218	10	health	health	NN
cord-306414-2dv3qced	218	11	and	and	CC
cord-306414-2dv3qced	218	12	disease	disease	NN
cord-306414-2dv3qced	218	13	have	have	VBP
cord-306414-2dv3qced	218	14	increased	increase	VBN
cord-306414-2dv3qced	218	15	dramatically	dramatically	RB
cord-306414-2dv3qced	218	16	in	in	IN
cord-306414-2dv3qced	218	17	recent	recent	JJ
cord-306414-2dv3qced	218	18	years	year	NNS
cord-306414-2dv3qced	218	19	due	due	IN
cord-306414-2dv3qced	218	20	to	to	IN
cord-306414-2dv3qced	218	21	advances	advance	NNS
cord-306414-2dv3qced	218	22	in	in	IN
cord-306414-2dv3qced	218	23	sequencing	sequencing	NN
cord-306414-2dv3qced	218	24	technologies	technology	NNS
cord-306414-2dv3qced	218	25	.	.	.
cord-306414-2dv3qced	219	1	TCR	TCR	NNP
cord-306414-2dv3qced	219	2	-	-	HYPH
cord-306414-2dv3qced	219	3	seq	seq	NNP
cord-306414-2dv3qced	219	4	has	have	VBZ
cord-306414-2dv3qced	219	5	provided	provide	VBN
cord-306414-2dv3qced	219	6	important	important	JJ
cord-306414-2dv3qced	219	7	new	new	JJ
cord-306414-2dv3qced	219	8	insights	insight	NNS
cord-306414-2dv3qced	219	9	into	into	IN
cord-306414-2dv3qced	219	10	the	the	DT
cord-306414-2dv3qced	219	11	human	human	JJ
cord-306414-2dv3qced	219	12	TCR	TCR	NNP
cord-306414-2dv3qced	219	13	repertoire	repertoire	NN
cord-306414-2dv3qced	219	14	,	,	,
cord-306414-2dv3qced	219	15	such	such	JJ
cord-306414-2dv3qced	219	16	as	as	IN
cord-306414-2dv3qced	219	17	the	the	DT
cord-306414-2dv3qced	219	18	more	more	RBR
cord-306414-2dv3qced	219	19	accurate	accurate	JJ
cord-306414-2dv3qced	219	20	estimation	estimation	NN
cord-306414-2dv3qced	219	21	of	of	IN
cord-306414-2dv3qced	219	22	the	the	DT
cord-306414-2dv3qced	219	23	repertoire	repertoire	NN
cord-306414-2dv3qced	219	24	size	size	NN
cord-306414-2dv3qced	219	25	and	and	CC
cord-306414-2dv3qced	219	26	the	the	DT
cord-306414-2dv3qced	219	27	presence	presence	NN
cord-306414-2dv3qced	219	28	of	of	IN
cord-306414-2dv3qced	219	29	TCRs	tcr	NNS
cord-306414-2dv3qced	219	30	that	that	WDT
cord-306414-2dv3qced	219	31	are	be	VBP
cord-306414-2dv3qced	219	32	shared	share	VBN
cord-306414-2dv3qced	219	33	by	by	IN
cord-306414-2dv3qced	219	34	multiple	multiple	JJ
cord-306414-2dv3qced	219	35	individuals	individual	NNS
cord-306414-2dv3qced	219	36	.	.	.
cord-306414-2dv3qced	220	1	TCR	TCR	NNP
cord-306414-2dv3qced	220	2	-	-	HYPH
cord-306414-2dv3qced	220	3	seq	seq	NNP
cord-306414-2dv3qced	220	4	is	be	VBZ
cord-306414-2dv3qced	220	5	different	different	JJ
cord-306414-2dv3qced	220	6	from	from	IN
cord-306414-2dv3qced	220	7	standard	standard	JJ
cord-306414-2dv3qced	220	8	DNA	DNA	NNP
cord-306414-2dv3qced	220	9	/	/	SYM
cord-306414-2dv3qced	220	10	RNA	RNA	NNP
cord-306414-2dv3qced	220	11	-	-	HYPH
cord-306414-2dv3qced	220	12	seq	seq	NN
cord-306414-2dv3qced	220	13	in	in	IN
cord-306414-2dv3qced	220	14	that	that	DT
cord-306414-2dv3qced	220	15	library	library	NN
cord-306414-2dv3qced	220	16	preparation	preparation	NN
cord-306414-2dv3qced	220	17	is	be	VBZ
cord-306414-2dv3qced	220	18	achieved	achieve	VBN
cord-306414-2dv3qced	220	19	through	through	IN
cord-306414-2dv3qced	220	20	selective	selective	JJ
cord-306414-2dv3qced	220	21	amplification	amplification	NN
cord-306414-2dv3qced	220	22	of	of	IN
cord-306414-2dv3qced	220	23	TCR	TCR	NNP
cord-306414-2dv3qced	220	24	gene	gene	NN
cord-306414-2dv3qced	220	25	products	product	NNS
cord-306414-2dv3qced	220	26	,	,	,
cord-306414-2dv3qced	220	27	allowing	allow	VBG
cord-306414-2dv3qced	220	28	the	the	DT
cord-306414-2dv3qced	220	29	capture	capture	NN
cord-306414-2dv3qced	220	30	of	of	IN
cord-306414-2dv3qced	220	31	the	the	DT
cord-306414-2dv3qced	220	32	TCR	TCR	NNP
cord-306414-2dv3qced	220	33	repertoire	repertoire	NN
cord-306414-2dv3qced	220	34	at	at	IN
cord-306414-2dv3qced	220	35	lower	low	JJR
cord-306414-2dv3qced	220	36	overall	overall	JJ
cord-306414-2dv3qced	220	37	financial	financial	JJ
cord-306414-2dv3qced	220	38	,	,	,
cord-306414-2dv3qced	220	39	reagent	reagent	NN
cord-306414-2dv3qced	220	40	,	,	,
cord-306414-2dv3qced	220	41	and	and	CC
cord-306414-2dv3qced	220	42	data	data	NN
cord-306414-2dv3qced	220	43	storage	storage	NN
cord-306414-2dv3qced	220	44	costs	cost	NNS
cord-306414-2dv3qced	220	45	.	.	.
cord-306414-2dv3qced	221	1	Different	different	JJ
cord-306414-2dv3qced	221	2	methods	method	NNS
cord-306414-2dv3qced	221	3	have	have	VBP
cord-306414-2dv3qced	221	4	been	be	VBN
cord-306414-2dv3qced	221	5	developed	develop	VBN
cord-306414-2dv3qced	221	6	to	to	TO
cord-306414-2dv3qced	221	7	analyze	analyze	VB
cord-306414-2dv3qced	221	8	the	the	DT
cord-306414-2dv3qced	221	9	TCR	TCR	NNP
cord-306414-2dv3qced	221	10	repertoire	repertoire	NN
cord-306414-2dv3qced	221	11	via	via	IN
cord-306414-2dv3qced	221	12	next	next	JJ
cord-306414-2dv3qced	221	13	generation	generation	NN
cord-306414-2dv3qced	221	14	sequencing	sequencing	NN
cord-306414-2dv3qced	221	15	using	use	VBG
cord-306414-2dv3qced	221	16	genomic	genomic	JJ
cord-306414-2dv3qced	221	17	DNA	dna	NN
cord-306414-2dv3qced	221	18	(	(	-LRB-
cord-306414-2dv3qced	221	19	gDNA	gDNA	NNP
cord-306414-2dv3qced	221	20	)	)	-RRB-
cord-306414-2dv3qced	221	21	and	and	CC
cord-306414-2dv3qced	221	22	RNA	RNA	NNP
cord-306414-2dv3qced	221	23	as	as	IN
cord-306414-2dv3qced	221	24	input	input	NN
cord-306414-2dv3qced	221	25	.	.	.
cord-306414-2dv3qced	222	1	Multiplex	multiplex	NN
cord-306414-2dv3qced	222	2	-19	-19	CD
cord-306414-2dv3qced	222	3	)	)	-RRB-
cord-306414-2dv3qced	223	1	to	to	TO
cord-306414-2dv3qced	223	2	Determine	determine	VB
cord-306414-2dv3qced	223	3	Herd	herd	VB
cord-306414-2dv3qced	223	4	Immunity	Immunity	NNP
cord-306414-2dv3qced	223	5	.	.	.
cord-306414-2dv3qced	224	1	(	(	-LRB-
cord-306414-2dv3qced	224	2	A	a	DT
cord-306414-2dv3qced	224	3	)	)	-RRB-
cord-306414-2dv3qced	224	4	Peripheral	peripheral	JJ
cord-306414-2dv3qced	224	5	blood	blood	NN
cord-306414-2dv3qced	224	6	samples	sample	NNS
cord-306414-2dv3qced	224	7	collected	collect	VBN
cord-306414-2dv3qced	224	8	from	from	IN
cord-306414-2dv3qced	224	9	COVID-19	covid-19	JJ
cord-306414-2dv3qced	224	10	infected	infected	JJ
cord-306414-2dv3qced	224	11	and	and	CC
cord-306414-2dv3qced	224	12	healthy	healthy	JJ
cord-306414-2dv3qced	224	13	uninfected	uninfected	JJ
cord-306414-2dv3qced	224	14	individuals	individual	NNS
cord-306414-2dv3qced	224	15	will	will	MD
cord-306414-2dv3qced	224	16	be	be	VB
cord-306414-2dv3qced	224	17	the	the	DT
cord-306414-2dv3qced	224	18	input	input	NN
cord-306414-2dv3qced	224	19	for	for	IN
cord-306414-2dv3qced	224	20	the	the	DT
cord-306414-2dv3qced	224	21	TCR	TCR	NNP
cord-306414-2dv3qced	224	22	repertoire	repertoire	NN
cord-306414-2dv3qced	224	23	analyses	analysis	NNS
cord-306414-2dv3qced	224	24	.	.	.
cord-306414-2dv3qced	225	1	Sequences	sequence	NNS
cord-306414-2dv3qced	225	2	and	and	CC
cord-306414-2dv3qced	225	3	motif	motif	NN
cord-306414-2dv3qced	225	4	analyses	analysis	NNS
cord-306414-2dv3qced	225	5	will	will	MD
cord-306414-2dv3qced	225	6	identify	identify	VB
cord-306414-2dv3qced	225	7	shared	share	VBN
cord-306414-2dv3qced	225	8	TCR	TCR	NNP
cord-306414-2dv3qced	225	9	clones	clone	NNS
cord-306414-2dv3qced	225	10	that	that	WDT
cord-306414-2dv3qced	225	11	are	be	VBP
cord-306414-2dv3qced	225	12	unique	unique	JJ
cord-306414-2dv3qced	225	13	to	to	IN
cord-306414-2dv3qced	225	14	severe	severe	JJ
cord-306414-2dv3qced	225	15	acute	acute	JJ
cord-306414-2dv3qced	225	16	respiratory	respiratory	JJ
cord-306414-2dv3qced	225	17	syndrome	syndrome	NN
cord-306414-2dv3qced	225	18	coronavirus	coronavirus	NN
cord-306414-2dv3qced	225	19	2	2	CD
cord-306414-2dv3qced	225	20	(	(	-LRB-
cord-306414-2dv3qced	225	21	SARS	SARS	NNP
cord-306414-2dv3qced	225	22	-	-	HYPH
cord-306414-2dv3qced	225	23	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	225	24	)	)	-RRB-
cord-306414-2dv3qced	225	25	epitopes	epitope	NNS
cord-306414-2dv3qced	225	26	.	.	.
cord-306414-2dv3qced	226	1	(	(	-LRB-
cord-306414-2dv3qced	226	2	B	b	NN
cord-306414-2dv3qced	226	3	)	)	-RRB-
cord-306414-2dv3qced	226	4	Prediction	prediction	NN
cord-306414-2dv3qced	226	5	algorithm	algorithm	NN
cord-306414-2dv3qced	226	6	generated	generate	VBN
cord-306414-2dv3qced	226	7	in	in	IN
cord-306414-2dv3qced	226	8	(	(	-LRB-
cord-306414-2dv3qced	226	9	A	a	NN
cord-306414-2dv3qced	226	10	)	)	-RRB-
cord-306414-2dv3qced	226	11	should	should	MD
cord-306414-2dv3qced	226	12	enable	enable	VB
cord-306414-2dv3qced	226	13	the	the	DT
cord-306414-2dv3qced	226	14	use	use	NN
cord-306414-2dv3qced	226	15	of	of	IN
cord-306414-2dv3qced	226	16	TCR	TCR	NNP
cord-306414-2dv3qced	226	17	sequencing	sequencing	NN
cord-306414-2dv3qced	226	18	analysis	analysis	NN
cord-306414-2dv3qced	226	19	of	of	IN
cord-306414-2dv3qced	226	20	patient	patient	NN
cord-306414-2dv3qced	226	21	with	with	IN
cord-306414-2dv3qced	226	22	unknown	unknown	JJ
cord-306414-2dv3qced	226	23	infection	infection	NN
cord-306414-2dv3qced	226	24	status	status	NN
cord-306414-2dv3qced	226	25	to	to	TO
cord-306414-2dv3qced	226	26	determine	determine	VB
cord-306414-2dv3qced	226	27	SARS	SARS	NNP
cord-306414-2dv3qced	226	28	-	-	HYPH
cord-306414-2dv3qced	226	29	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	226	30	exposure	exposure	NN
cord-306414-2dv3qced	226	31	history	history	NN
cord-306414-2dv3qced	226	32	in	in	IN
cord-306414-2dv3qced	226	33	an	an	DT
cord-306414-2dv3qced	226	34	individual	individual	NN
cord-306414-2dv3qced	226	35	.	.	.
cord-306414-2dv3qced	227	1	This	this	DT
cord-306414-2dv3qced	227	2	information	information	NN
cord-306414-2dv3qced	227	3	can	can	MD
cord-306414-2dv3qced	227	4	be	be	VB
cord-306414-2dv3qced	227	5	valuable	valuable	JJ
cord-306414-2dv3qced	227	6	in	in	IN
cord-306414-2dv3qced	227	7	the	the	DT
cord-306414-2dv3qced	227	8	fight	fight	NN
cord-306414-2dv3qced	227	9	against	against	IN
cord-306414-2dv3qced	227	10	COVID-19	COVID-19	NNP
cord-306414-2dv3qced	227	11	as	as	IN
cord-306414-2dv3qced	227	12	it	-PRON-	PRP
cord-306414-2dv3qced	227	13	can	can	MD
cord-306414-2dv3qced	227	14	be	be	VB
cord-306414-2dv3qced	227	15	applied	apply	VBN
cord-306414-2dv3qced	227	16	to	to	TO
cord-306414-2dv3qced	227	17	observe	observe	VB
cord-306414-2dv3qced	227	18	the	the	DT
cord-306414-2dv3qced	227	19	degree	degree	NN
cord-306414-2dv3qced	227	20	of	of	IN
cord-306414-2dv3qced	227	21	herd	herd	NN
cord-306414-2dv3qced	227	22	immunity	immunity	NN
cord-306414-2dv3qced	227	23	in	in	IN
cord-306414-2dv3qced	227	24	a	a	DT
cord-306414-2dv3qced	227	25	particular	particular	JJ
cord-306414-2dv3qced	227	26	population	population	NN
cord-306414-2dv3qced	227	27	.	.	.
cord-306414-2dv3qced	228	1	PCR-	PCR-	NNP
cord-306414-2dv3qced	228	2	,	,	,
cord-306414-2dv3qced	228	3	target	target	VB
cord-306414-2dv3qced	228	4	enrichment-	enrichment-	NN
cord-306414-2dv3qced	228	5	,	,	,
cord-306414-2dv3qced	228	6	and	and	CC
cord-306414-2dv3qced	228	7	5′-RACE	5′-race	CD
cord-306414-2dv3qced	229	1	(	(	-LRB-
cord-306414-2dv3qced	229	2	RNA	RNA	NNP
cord-306414-2dv3qced	229	3	only)-based	only)-base	VBN
cord-306414-2dv3qced	229	4	approaches	approach	NNS
cord-306414-2dv3qced	229	5	are	be	VBP
cord-306414-2dv3qced	229	6	the	the	DT
cord-306414-2dv3qced	229	7	most	most	RBS
cord-306414-2dv3qced	229	8	widely	widely	RB
cord-306414-2dv3qced	229	9	used	use	VBN
cord-306414-2dv3qced	229	10	TCR	TCR	NNP
cord-306414-2dv3qced	229	11	-	-	HYPH
cord-306414-2dv3qced	229	12	seq	seq	NNP
cord-306414-2dv3qced	229	13	strategies	strategy	NNS
cord-306414-2dv3qced	229	14	[	[	-LRB-
cord-306414-2dv3qced	229	15	71	71	CD
cord-306414-2dv3qced	229	16	]	]	-RRB-
cord-306414-2dv3qced	229	17	.	.	.
cord-306414-2dv3qced	230	1	Multiplex	Multiplex	NNP
cord-306414-2dv3qced	230	2	PCR	pcr	NN
cord-306414-2dv3qced	230	3	-	-	HYPH
cord-306414-2dv3qced	230	4	based	base	VBN
cord-306414-2dv3qced	230	5	methods	method	NNS
cord-306414-2dv3qced	230	6	involve	involve	VBP
cord-306414-2dv3qced	230	7	the	the	DT
cord-306414-2dv3qced	230	8	use	use	NN
cord-306414-2dv3qced	230	9	of	of	IN
cord-306414-2dv3qced	230	10	a	a	DT
cord-306414-2dv3qced	230	11	primer	primer	NN
cord-306414-2dv3qced	230	12	mix	mix	NN
cord-306414-2dv3qced	230	13	that	that	WDT
cord-306414-2dv3qced	230	14	anneals	anneal	VBZ
cord-306414-2dv3qced	230	15	to	to	IN
cord-306414-2dv3qced	230	16	every	every	DT
cord-306414-2dv3qced	230	17	V	V	NNP
cord-306414-2dv3qced	230	18	and	and	CC
cord-306414-2dv3qced	230	19	J	J	NNP
cord-306414-2dv3qced	230	20	exon	exon	NNP
cord-306414-2dv3qced	230	21	and	and	CC
cord-306414-2dv3qced	230	22	the	the	DT
cord-306414-2dv3qced	230	23	constant	constant	JJ
cord-306414-2dv3qced	230	24	region	region	NN
cord-306414-2dv3qced	230	25	.	.	.
cord-306414-2dv3qced	231	1	However	however	RB
cord-306414-2dv3qced	231	2	,	,	,
cord-306414-2dv3qced	231	3	preferential	preferential	JJ
cord-306414-2dv3qced	231	4	amplification	amplification	NN
cord-306414-2dv3qced	231	5	of	of	IN
cord-306414-2dv3qced	231	6	highly	highly	RB
cord-306414-2dv3qced	231	7	abundant	abundant	JJ
cord-306414-2dv3qced	231	8	gene	gene	NN
cord-306414-2dv3qced	231	9	products	product	NNS
cord-306414-2dv3qced	231	10	can	can	MD
cord-306414-2dv3qced	231	11	occur	occur	VB
cord-306414-2dv3qced	231	12	when	when	WRB
cord-306414-2dv3qced	231	13	using	use	VBG
cord-306414-2dv3qced	231	14	multiplex	multiplex	NN
cord-306414-2dv3qced	231	15	PCR	PCR	NNP
cord-306414-2dv3qced	231	16	,	,	,
cord-306414-2dv3qced	231	17	contributing	contribute	VBG
cord-306414-2dv3qced	231	18	to	to	IN
cord-306414-2dv3qced	231	19	inaccuracies	inaccuracy	NNS
cord-306414-2dv3qced	231	20	in	in	IN
cord-306414-2dv3qced	231	21	reported	report	VBN
cord-306414-2dv3qced	231	22	clone	clone	NN
cord-306414-2dv3qced	231	23	frequencies	frequency	NNS
cord-306414-2dv3qced	231	24	.	.	.
cord-306414-2dv3qced	232	1	Additionally	additionally	RB
cord-306414-2dv3qced	232	2	,	,	,
cord-306414-2dv3qced	232	3	intronic	intronic	JJ
cord-306414-2dv3qced	232	4	sequences	sequence	NNS
cord-306414-2dv3qced	232	5	and	and	CC
cord-306414-2dv3qced	232	6	incomplete	incomplete	JJ
cord-306414-2dv3qced	232	7	VDJ	VDJ	NNP
cord-306414-2dv3qced	232	8	recombination	recombination	NN
cord-306414-2dv3qced	232	9	products	product	NNS
cord-306414-2dv3qced	232	10	may	may	MD
cord-306414-2dv3qced	232	11	contribute	contribute	VB
cord-306414-2dv3qced	232	12	to	to	IN
cord-306414-2dv3qced	232	13	data	data	NN
cord-306414-2dv3qced	232	14	noise	noise	NN
cord-306414-2dv3qced	232	15	when	when	WRB
cord-306414-2dv3qced	232	16	using	use	VBG
cord-306414-2dv3qced	232	17	gDNA	gdna	NN
cord-306414-2dv3qced	232	18	samples	sample	NNS
cord-306414-2dv3qced	232	19	.	.	.
cord-306414-2dv3qced	233	1	Target	target	VB
cord-306414-2dv3qced	233	2	enrichment	enrichment	NN
cord-306414-2dv3qced	233	3	strategies	strategy	NNS
cord-306414-2dv3qced	233	4	utilize	utilize	VBP
cord-306414-2dv3qced	233	5	probes	probe	NNS
cord-306414-2dv3qced	233	6	to	to	TO
cord-306414-2dv3qced	233	7	capture	capture	VB
cord-306414-2dv3qced	233	8	TCR	TCR	NNP
cord-306414-2dv3qced	233	9	gDNA	gDNA	NNP
cord-306414-2dv3qced	233	10	/	/	SYM
cord-306414-2dv3qced	233	11	RNA	RNA	NNP
cord-306414-2dv3qced	233	12	sequences	sequence	NNS
cord-306414-2dv3qced	233	13	after	after	IN
cord-306414-2dv3qced	233	14	initial	initial	JJ
cord-306414-2dv3qced	233	15	library	library	NN
cord-306414-2dv3qced	233	16	preparation	preparation	NN
cord-306414-2dv3qced	233	17	using	use	VBG
cord-306414-2dv3qced	233	18	compatible	compatible	JJ
cord-306414-2dv3qced	233	19	kits	kit	NNS
cord-306414-2dv3qced	233	20	(	(	-LRB-
cord-306414-2dv3qced	233	21	such	such	JJ
cord-306414-2dv3qced	233	22	as	as	IN
cord-306414-2dv3qced	233	23	the	the	DT
cord-306414-2dv3qced	233	24	Illumina	Illumina	NNP
cord-306414-2dv3qced	233	25	TruSeq	TruSeq	NNP
cord-306414-2dv3qced	233	26	kit	kit	NN
cord-306414-2dv3qced	233	27	or	or	CC
cord-306414-2dv3qced	233	28	the	the	DT
cord-306414-2dv3qced	233	29	Agilent	Agilent	NNP
cord-306414-2dv3qced	233	30	SureSelectXT	SureSelectXT	NNP
cord-306414-2dv3qced	233	31	kit	kit	NN
cord-306414-2dv3qced	233	32	)	)	-RRB-
cord-306414-2dv3qced	233	33	followed	follow	VBN
cord-306414-2dv3qced	233	34	by	by	IN
cord-306414-2dv3qced	233	35	relatively	relatively	RB
cord-306414-2dv3qced	233	36	few	few	JJ
cord-306414-2dv3qced	233	37	cycles	cycle	NNS
cord-306414-2dv3qced	233	38	of	of	IN
cord-306414-2dv3qced	233	39	multiplex	multiplex	JJ
cord-306414-2dv3qced	233	40	PCR	pcr	NN
cord-306414-2dv3qced	233	41	amplification	amplification	NN
cord-306414-2dv3qced	233	42	[	[	-LRB-
cord-306414-2dv3qced	233	43	72	72	CD
cord-306414-2dv3qced	233	44	,	,	,
cord-306414-2dv3qced	233	45	73	73	CD
cord-306414-2dv3qced	233	46	]	]	-RRB-
cord-306414-2dv3qced	233	47	.	.	.
cord-306414-2dv3qced	234	1	This	this	DT
cord-306414-2dv3qced	234	2	method	method	NN
cord-306414-2dv3qced	234	3	reduces	reduce	VBZ
cord-306414-2dv3qced	234	4	the	the	DT
cord-306414-2dv3qced	234	5	extent	extent	NN
cord-306414-2dv3qced	234	6	of	of	IN
cord-306414-2dv3qced	234	7	amplification	amplification	NN
cord-306414-2dv3qced	234	8	bias	bias	NN
cord-306414-2dv3qced	234	9	seen	see	VBN
cord-306414-2dv3qced	234	10	in	in	IN
cord-306414-2dv3qced	234	11	standard	standard	JJ
cord-306414-2dv3qced	234	12	multiplex	multiplex	NN
cord-306414-2dv3qced	234	13	PCR	pcr	NN
cord-306414-2dv3qced	234	14	but	but	CC
cord-306414-2dv3qced	234	15	is	be	VBZ
cord-306414-2dv3qced	234	16	more	more	JJR
cord-306414-2dv3qced	234	17	labor	labor	NN
cord-306414-2dv3qced	234	18	/	/	SYM
cord-306414-2dv3qced	234	19	time	time	NN
cord-306414-2dv3qced	234	20	intensive	intensive	JJ
cord-306414-2dv3qced	234	21	and	and	CC
cord-306414-2dv3qced	234	22	does	do	VBZ
cord-306414-2dv3qced	234	23	not	not	RB
cord-306414-2dv3qced	234	24	resolve	resolve	VB
cord-306414-2dv3qced	234	25	the	the	DT
cord-306414-2dv3qced	234	26	issues	issue	NNS
cord-306414-2dv3qced	234	27	associated	associate	VBN
cord-306414-2dv3qced	234	28	with	with	IN
cord-306414-2dv3qced	234	29	gDNA	gdna	JJ
cord-306414-2dv3qced	234	30	input	input	NN
cord-306414-2dv3qced	234	31	.	.	.
cord-306414-2dv3qced	235	1	The	the	DT
cord-306414-2dv3qced	235	2	5′-RACE	5′-race	CD
cord-306414-2dv3qced	235	3	method	method	NN
cord-306414-2dv3qced	235	4	with	with	IN
cord-306414-2dv3qced	235	5	an	an	DT
cord-306414-2dv3qced	235	6	RNA	RNA	NNP
cord-306414-2dv3qced	235	7	input	input	NN
cord-306414-2dv3qced	235	8	involves	involve	VBZ
cord-306414-2dv3qced	235	9	the	the	DT
cord-306414-2dv3qced	235	10	reverse	reverse	JJ
cord-306414-2dv3qced	235	11	transcription	transcription	NN
cord-306414-2dv3qced	235	12	of	of	IN
cord-306414-2dv3qced	235	13	TCR	TCR	NNP
cord-306414-2dv3qced	235	14	transcripts	transcript	NNS
cord-306414-2dv3qced	235	15	followed	follow	VBN
cord-306414-2dv3qced	235	16	by	by	IN
cord-306414-2dv3qced	235	17	the	the	DT
cord-306414-2dv3qced	235	18	addition	addition	NN
cord-306414-2dv3qced	235	19	of	of	IN
cord-306414-2dv3qced	235	20	a	a	DT
cord-306414-2dv3qced	235	21	known	know	VBN
cord-306414-2dv3qced	235	22	sequence	sequence	NN
cord-306414-2dv3qced	235	23	at	at	IN
cord-306414-2dv3qced	235	24	the	the	DT
cord-306414-2dv3qced	235	25	5′	5′	CD
cord-306414-2dv3qced	235	26	end	end	NN
cord-306414-2dv3qced	235	27	of	of	IN
cord-306414-2dv3qced	235	28	each	each	DT
cord-306414-2dv3qced	235	29	cDNA	cdna	NN
cord-306414-2dv3qced	235	30	molecule	molecule	NN
cord-306414-2dv3qced	235	31	.	.	.
cord-306414-2dv3qced	236	1	This	this	DT
cord-306414-2dv3qced	236	2	5′	5′	CD
cord-306414-2dv3qced	236	3	sequence	sequence	NN
cord-306414-2dv3qced	236	4	is	be	VBZ
cord-306414-2dv3qced	236	5	leveraged	leverage	VBN
cord-306414-2dv3qced	236	6	along	along	IN
cord-306414-2dv3qced	236	7	with	with	IN
cord-306414-2dv3qced	236	8	the	the	DT
cord-306414-2dv3qced	236	9	highly	highly	RB
cord-306414-2dv3qced	236	10	conserved	conserve	VBN
cord-306414-2dv3qced	236	11	TCR	TCR	NNP
cord-306414-2dv3qced	236	12	α	α	NNP
cord-306414-2dv3qced	236	13	and	and	CC
cord-306414-2dv3qced	236	14	β	β	NN
cord-306414-2dv3qced	236	15	constant	constant	JJ
cord-306414-2dv3qced	236	16	region	region	NN
cord-306414-2dv3qced	236	17	during	during	IN
cord-306414-2dv3qced	236	18	nested	nest	VBN
cord-306414-2dv3qced	236	19	PCR	PCR	NNP
cord-306414-2dv3qced	236	20	(	(	-LRB-
cord-306414-2dv3qced	236	21	separate	separate	JJ
cord-306414-2dv3qced	236	22	primers	primer	NNS
cord-306414-2dv3qced	236	23	needed	need	VBD
cord-306414-2dv3qced	236	24	to	to	TO
cord-306414-2dv3qced	236	25	amplify	amplify	VB
cord-306414-2dv3qced	236	26	either	either	CC
cord-306414-2dv3qced	236	27	α	α	NN
cord-306414-2dv3qced	236	28	or	or	CC
cord-306414-2dv3qced	236	29	β	β	NN
cord-306414-2dv3qced	236	30	transcripts	transcript	NNS
cord-306414-2dv3qced	236	31	)	)	-RRB-
cord-306414-2dv3qced	236	32	to	to	TO
cord-306414-2dv3qced	236	33	achieve	achieve	VB
cord-306414-2dv3qced	236	34	equally	equally	RB
cord-306414-2dv3qced	236	35	efficient	efficient	JJ
cord-306414-2dv3qced	236	36	amplification	amplification	NN
cord-306414-2dv3qced	236	37	of	of	IN
cord-306414-2dv3qced	236	38	used	use	VBN
cord-306414-2dv3qced	236	39	as	as	IN
cord-306414-2dv3qced	236	40	an	an	DT
cord-306414-2dv3qced	236	41	input	input	NN
cord-306414-2dv3qced	236	42	for	for	IN
cord-306414-2dv3qced	236	43	TCR	TCR	NNP
cord-306414-2dv3qced	236	44	sequencing	sequencing	NN
cord-306414-2dv3qced	236	45	library	library	NN
cord-306414-2dv3qced	236	46	preparation	preparation	NN
cord-306414-2dv3qced	236	47	.	.	.
cord-306414-2dv3qced	237	1	(	(	-LRB-
cord-306414-2dv3qced	237	2	C	C	NNP
cord-306414-2dv3qced	237	3	)	)	-RRB-
cord-306414-2dv3qced	238	1	TCR	TCR	NNP
cord-306414-2dv3qced	238	2	sequencing	sequencing	NN
cord-306414-2dv3qced	238	3	will	will	MD
cord-306414-2dv3qced	238	4	be	be	VB
cord-306414-2dv3qced	238	5	done	do	VBN
cord-306414-2dv3qced	238	6	using	use	VBG
cord-306414-2dv3qced	238	7	Illumina	Illumina	NNP
cord-306414-2dv3qced	238	8	or	or	CC
cord-306414-2dv3qced	238	9	other	other	JJ
cord-306414-2dv3qced	238	10	sequencing	sequencing	NN
cord-306414-2dv3qced	238	11	platforms	platform	NNS
cord-306414-2dv3qced	238	12	and	and	CC
cord-306414-2dv3qced	238	13	resulting	result	VBG
cord-306414-2dv3qced	238	14	data	datum	NNS
cord-306414-2dv3qced	238	15	analyzed	analyze	VBD
cord-306414-2dv3qced	238	16	using	use	VBG
cord-306414-2dv3qced	238	17	popular	popular	JJ
cord-306414-2dv3qced	238	18	bioinformatic	bioinformatic	JJ
cord-306414-2dv3qced	238	19	tools	tool	NNS
cord-306414-2dv3qced	238	20	to	to	TO
cord-306414-2dv3qced	238	21	characterize	characterize	VB
cord-306414-2dv3qced	238	22	the	the	DT
cord-306414-2dv3qced	238	23	TCR	TCR	NNP
cord-306414-2dv3qced	238	24	repertoire	repertoire	NN
cord-306414-2dv3qced	238	25	of	of	IN
cord-306414-2dv3qced	238	26	SARS	SARS	NNP
cord-306414-2dv3qced	238	27	-	-	HYPH
cord-306414-2dv3qced	238	28	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	238	29	infected	infect	VBD
cord-306414-2dv3qced	238	30	/	/	SYM
cord-306414-2dv3qced	238	31	vaccinated	vaccinate	VBN
cord-306414-2dv3qced	238	32	individuals	individual	NNS
cord-306414-2dv3qced	238	33	.	.	.
cord-306414-2dv3qced	239	1	(	(	-LRB-
cord-306414-2dv3qced	239	2	D	d	NN
cord-306414-2dv3qced	239	3	)	)	-RRB-
cord-306414-2dv3qced	240	1	The	the	DT
cord-306414-2dv3qced	240	2	information	information	NN
cord-306414-2dv3qced	240	3	obtained	obtain	VBN
cord-306414-2dv3qced	240	4	can	can	MD
cord-306414-2dv3qced	240	5	be	be	VB
cord-306414-2dv3qced	240	6	used	use	VBN
cord-306414-2dv3qced	240	7	to	to	TO
cord-306414-2dv3qced	240	8	advance	advance	VB
cord-306414-2dv3qced	240	9	immunotherapy	immunotherapy	NN
cord-306414-2dv3qced	240	10	development	development	NN
cord-306414-2dv3qced	240	11	,	,	,
cord-306414-2dv3qced	240	12	characterize	characterize	VB
cord-306414-2dv3qced	240	13	TCR	TCR	NNP
cord-306414-2dv3qced	240	14	repertoires	repertoire	NNS
cord-306414-2dv3qced	240	15	in	in	IN
cord-306414-2dv3qced	240	16	specific	specific	JJ
cord-306414-2dv3qced	240	17	populations	population	NNS
cord-306414-2dv3qced	240	18	,	,	,
cord-306414-2dv3qced	240	19	and	and	CC
cord-306414-2dv3qced	240	20	monitor	monitor	VB
cord-306414-2dv3qced	240	21	herd	herd	NN
cord-306414-2dv3qced	240	22	immunity	immunity	NN
cord-306414-2dv3qced	240	23	.	.	.
cord-306414-2dv3qced	241	1	all	all	DT
cord-306414-2dv3qced	241	2	TCR	TCR	NNP
cord-306414-2dv3qced	241	3	transcripts	transcript	NNS
cord-306414-2dv3qced	241	4	,	,	,
cord-306414-2dv3qced	241	5	regardless	regardless	RB
cord-306414-2dv3qced	241	6	of	of	IN
cord-306414-2dv3qced	241	7	abundance	abundance	NN
cord-306414-2dv3qced	241	8	[	[	-LRB-
cord-306414-2dv3qced	241	9	74	74	CD
cord-306414-2dv3qced	241	10	,	,	,
cord-306414-2dv3qced	241	11	75	75	CD
cord-306414-2dv3qced	241	12	]	]	-RRB-
cord-306414-2dv3qced	241	13	.	.	.
cord-306414-2dv3qced	242	1	While	while	IN
cord-306414-2dv3qced	242	2	the	the	DT
cord-306414-2dv3qced	242	3	5′-RACE	5′-RACE	NNP
cord-306414-2dv3qced	242	4	approach	approach	NN
cord-306414-2dv3qced	242	5	avoids	avoid	VBZ
cord-306414-2dv3qced	242	6	the	the	DT
cord-306414-2dv3qced	242	7	PCR	PCR	NNP
cord-306414-2dv3qced	242	8	bias	bias	NN
cord-306414-2dv3qced	242	9	seen	see	VBN
cord-306414-2dv3qced	242	10	in	in	IN
cord-306414-2dv3qced	242	11	the	the	DT
cord-306414-2dv3qced	242	12	other	other	JJ
cord-306414-2dv3qced	242	13	two	two	CD
cord-306414-2dv3qced	242	14	methods	method	NNS
cord-306414-2dv3qced	242	15	,	,	,
cord-306414-2dv3qced	242	16	it	-PRON-	PRP
cord-306414-2dv3qced	242	17	requires	require	VBZ
cord-306414-2dv3qced	242	18	the	the	DT
cord-306414-2dv3qced	242	19	use	use	NN
cord-306414-2dv3qced	242	20	of	of	IN
cord-306414-2dv3qced	242	21	sequencing	sequencing	NN
cord-306414-2dv3qced	242	22	platforms	platform	NNS
cord-306414-2dv3qced	242	23	capable	capable	JJ
cord-306414-2dv3qced	242	24	of	of	IN
cord-306414-2dv3qced	242	25	long	long	JJ
cord-306414-2dv3qced	242	26	reads	read	NNS
cord-306414-2dv3qced	242	27	,	,	,
cord-306414-2dv3qced	242	28	such	such	JJ
cord-306414-2dv3qced	242	29	as	as	IN
cord-306414-2dv3qced	242	30	the	the	DT
cord-306414-2dv3qced	242	31	Illumina	Illumina	NNP
cord-306414-2dv3qced	242	32	Miseq	Miseq	NNP
cord-306414-2dv3qced	242	33	,	,	,
cord-306414-2dv3qced	242	34	as	as	IN
cord-306414-2dv3qced	242	35	fragment	fragment	NN
cord-306414-2dv3qced	242	36	sizes	size	NNS
cord-306414-2dv3qced	242	37	can	can	MD
cord-306414-2dv3qced	242	38	exceed	exceed	VB
cord-306414-2dv3qced	242	39	600	600	CD
cord-306414-2dv3qced	242	40	bp	bp	NNP
cord-306414-2dv3qced	242	41	.	.	.
cord-306414-2dv3qced	243	1	While	while	IN
cord-306414-2dv3qced	243	2	bulk	bulk	JJ
cord-306414-2dv3qced	243	3	TCR	TCR	NNP
cord-306414-2dv3qced	243	4	-	-	HYPH
cord-306414-2dv3qced	243	5	seq	seq	NNP
cord-306414-2dv3qced	243	6	(	(	-LRB-
cord-306414-2dv3qced	243	7	TCR	TCR	NNP
cord-306414-2dv3qced	243	8	-	-	HYPH
cord-306414-2dv3qced	243	9	seq	seq	NNP
cord-306414-2dv3qced	243	10	of	of	IN
cord-306414-2dv3qced	243	11	a	a	DT
cord-306414-2dv3qced	243	12	heterogeneous	heterogeneous	JJ
cord-306414-2dv3qced	243	13	T	t	NN
cord-306414-2dv3qced	243	14	cell	cell	NN
cord-306414-2dv3qced	243	15	population	population	NN
cord-306414-2dv3qced	243	16	)	)	-RRB-
cord-306414-2dv3qced	243	17	via	via	IN
cord-306414-2dv3qced	243	18	the	the	DT
cord-306414-2dv3qced	243	19	earlier	early	RBR
cord-306414-2dv3qced	243	20	-	-	HYPH
cord-306414-2dv3qced	243	21	discussed	discuss	VBN
cord-306414-2dv3qced	243	22	strategies	strategy	NNS
cord-306414-2dv3qced	243	23	can	can	MD
cord-306414-2dv3qced	243	24	provide	provide	VB
cord-306414-2dv3qced	243	25	information	information	NN
cord-306414-2dv3qced	243	26	about	about	IN
cord-306414-2dv3qced	243	27	the	the	DT
cord-306414-2dv3qced	243	28	evolution	evolution	NN
cord-306414-2dv3qced	243	29	,	,	,
cord-306414-2dv3qced	243	30	the	the	DT
cord-306414-2dv3qced	243	31	dynamic	dynamic	JJ
cord-306414-2dv3qced	243	32	,	,	,
cord-306414-2dv3qced	243	33	and	and	CC
cord-306414-2dv3qced	243	34	the	the	DT
cord-306414-2dv3qced	243	35	architecture	architecture	NN
cord-306414-2dv3qced	243	36	of	of	IN
cord-306414-2dv3qced	243	37	the	the	DT
cord-306414-2dv3qced	243	38	TCR	TCR	NNP
cord-306414-2dv3qced	243	39	repertoire	repertoire	NN
cord-306414-2dv3qced	243	40	during	during	IN
cord-306414-2dv3qced	243	41	the	the	DT
cord-306414-2dv3qced	243	42	course	course	NN
cord-306414-2dv3qced	243	43	of	of	IN
cord-306414-2dv3qced	243	44	SARS	SARS	NNP
cord-306414-2dv3qced	243	45	-	-	HYPH
cord-306414-2dv3qced	243	46	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	243	47	infections	infection	NNS
cord-306414-2dv3qced	243	48	,	,	,
cord-306414-2dv3qced	243	49	it	-PRON-	PRP
cord-306414-2dv3qced	243	50	can	can	MD
cord-306414-2dv3qced	243	51	not	not	RB
cord-306414-2dv3qced	243	52	be	be	VB
cord-306414-2dv3qced	243	53	used	use	VBN
cord-306414-2dv3qced	243	54	to	to	TO
cord-306414-2dv3qced	243	55	identify	identify	VB
cord-306414-2dv3qced	243	56	the	the	DT
cord-306414-2dv3qced	243	57	exact	exact	JJ
cord-306414-2dv3qced	243	58	TCR	TCR	NNP
cord-306414-2dv3qced	243	59	α	α	NNP
cord-306414-2dv3qced	243	60	/	/	SYM
cord-306414-2dv3qced	243	61	β	β	NN
cord-306414-2dv3qced	243	62	pairs	pair	NNS
cord-306414-2dv3qced	243	63	that	that	WDT
cord-306414-2dv3qced	243	64	participate	participate	VBP
cord-306414-2dv3qced	243	65	in	in	IN
cord-306414-2dv3qced	243	66	antiviral	antiviral	JJ
cord-306414-2dv3qced	243	67	responses	response	NNS
cord-306414-2dv3qced	243	68	(	(	-LRB-
cord-306414-2dv3qced	243	69	only	only	RB
cord-306414-2dv3qced	243	70	draw	draw	VB
cord-306414-2dv3qced	243	71	inferences	inference	NNS
cord-306414-2dv3qced	243	72	based	base	VBN
cord-306414-2dv3qced	243	73	on	on	IN
cord-306414-2dv3qced	243	74	clone	clone	NN
cord-306414-2dv3qced	243	75	frequency	frequency	NN
cord-306414-2dv3qced	243	76	changes	change	NNS
cord-306414-2dv3qced	243	77	)	)	-RRB-
cord-306414-2dv3qced	243	78	[	[	-LRB-
cord-306414-2dv3qced	243	79	52	52	CD
cord-306414-2dv3qced	243	80	,	,	,
cord-306414-2dv3qced	243	81	57	57	CD
cord-306414-2dv3qced	243	82	]	]	-RRB-
cord-306414-2dv3qced	243	83	.	.	.
cord-306414-2dv3qced	244	1	Additionally	additionally	RB
cord-306414-2dv3qced	244	2	,	,	,
cord-306414-2dv3qced	244	3	bulk	bulk	JJ
cord-306414-2dv3qced	244	4	TCR	TCR	NNP
cord-306414-2dv3qced	244	5	-	-	HYPH
cord-306414-2dv3qced	244	6	seq	seq	NNP
cord-306414-2dv3qced	244	7	will	will	MD
cord-306414-2dv3qced	244	8	likely	likely	RB
cord-306414-2dv3qced	244	9	capture	capture	VB
cord-306414-2dv3qced	244	10	bystander	bystander	NN
cord-306414-2dv3qced	244	11	activated	activate	VBN
cord-306414-2dv3qced	244	12	and	and	CC
cord-306414-2dv3qced	244	13	expanded	expand	VBD
cord-306414-2dv3qced	244	14	T	t	NN
cord-306414-2dv3qced	244	15	cells	cell	NNS
cord-306414-2dv3qced	244	16	,	,	,
cord-306414-2dv3qced	244	17	contributing	contribute	VBG
cord-306414-2dv3qced	244	18	to	to	IN
cord-306414-2dv3qced	244	19	data	data	NN
cord-306414-2dv3qced	244	20	noise	noise	NN
cord-306414-2dv3qced	244	21	.	.	.
cord-306414-2dv3qced	245	1	Single	single	JJ
cord-306414-2dv3qced	245	2	-	-	HYPH
cord-306414-2dv3qced	245	3	cell	cell	NN
cord-306414-2dv3qced	245	4	TCR	TCR	NNP
cord-306414-2dv3qced	245	5	-	-	HYPH
cord-306414-2dv3qced	245	6	seq	seq	NNP
cord-306414-2dv3qced	245	7	in	in	IN
cord-306414-2dv3qced	245	8	tandem	tandem	NN
cord-306414-2dv3qced	245	9	with	with	IN
cord-306414-2dv3qced	245	10	singlecell	singlecell	JJ
cord-306414-2dv3qced	245	11	flow	flow	NN
cord-306414-2dv3qced	245	12	cytometry	cytometry	NN
cord-306414-2dv3qced	245	13	sorting	sorting	NN
cord-306414-2dv3qced	245	14	is	be	VBZ
cord-306414-2dv3qced	245	15	an	an	DT
cord-306414-2dv3qced	245	16	approach	approach	NN
cord-306414-2dv3qced	245	17	to	to	TO
cord-306414-2dv3qced	245	18	precisely	precisely	RB
cord-306414-2dv3qced	245	19	identify	identify	VB
cord-306414-2dv3qced	245	20	SARS	SARS	NNP
cord-306414-2dv3qced	245	21	-	-	HYPH
cord-306414-2dv3qced	245	22	CoV-2-specific	CoV-2-specific	NNP
cord-306414-2dv3qced	245	23	T	t	NN
cord-306414-2dv3qced	245	24	cells	cell	NNS
cord-306414-2dv3qced	245	25	.	.	.
cord-306414-2dv3qced	246	1	Single	single	JJ
cord-306414-2dv3qced	246	2	-	-	HYPH
cord-306414-2dv3qced	246	3	cell	cell	NN
cord-306414-2dv3qced	246	4	TCR	TCR	NNP
cord-306414-2dv3qced	246	5	analysis	analysis	NN
cord-306414-2dv3qced	246	6	can	can	MD
cord-306414-2dv3qced	246	7	be	be	VB
cord-306414-2dv3qced	246	8	limited	limit	VBN
cord-306414-2dv3qced	246	9	by	by	IN
cord-306414-2dv3qced	246	10	their	-PRON-	PRP$
cord-306414-2dv3qced	246	11	depth	depth	NN
cord-306414-2dv3qced	246	12	and	and	CC
cord-306414-2dv3qced	246	13	their	-PRON-	PRP$
cord-306414-2dv3qced	246	14	ability	ability	NN
cord-306414-2dv3qced	246	15	to	to	TO
cord-306414-2dv3qced	246	16	capture	capture	VB
cord-306414-2dv3qced	246	17	minor	minor	JJ
cord-306414-2dv3qced	246	18	clones	clone	NNS
cord-306414-2dv3qced	246	19	.	.	.
cord-306414-2dv3qced	247	1	Regardless	regardless	RB
cord-306414-2dv3qced	247	2	,	,	,
cord-306414-2dv3qced	247	3	these	these	DT
cord-306414-2dv3qced	247	4	approaches	approach	NNS
cord-306414-2dv3qced	247	5	generate	generate	VBP
cord-306414-2dv3qced	247	6	millions	million	NNS
cord-306414-2dv3qced	247	7	of	of	IN
cord-306414-2dv3qced	247	8	TCR	TCR	NNP
cord-306414-2dv3qced	247	9	sequences	sequence	NNS
cord-306414-2dv3qced	247	10	in	in	IN
cord-306414-2dv3qced	247	11	one	one	CD
cord-306414-2dv3qced	247	12	experiment	experiment	NN
cord-306414-2dv3qced	247	13	and	and	CC
cord-306414-2dv3qced	247	14	enable	enable	VB
cord-306414-2dv3qced	247	15	the	the	DT
cord-306414-2dv3qced	247	16	characterization	characterization	NN
cord-306414-2dv3qced	247	17	of	of	IN
cord-306414-2dv3qced	247	18	the	the	DT
cord-306414-2dv3qced	247	19	TCR	TCR	NNP
cord-306414-2dv3qced	247	20	repertoire	repertoire	NN
cord-306414-2dv3qced	247	21	in	in	IN
cord-306414-2dv3qced	247	22	COVID-19	COVID-19	NNP
cord-306414-2dv3qced	247	23	patients	patient	NNS
cord-306414-2dv3qced	247	24	[	[	-LRB-
cord-306414-2dv3qced	247	25	73	73	CD
cord-306414-2dv3qced	247	26	,	,	,
cord-306414-2dv3qced	247	27	76	76	CD
cord-306414-2dv3qced	247	28	]	]	-RRB-
cord-306414-2dv3qced	247	29	.	.	.
cord-306414-2dv3qced	248	1	Computational	Computational	NNP
cord-306414-2dv3qced	248	2	Tools	Tools	NNPS
cord-306414-2dv3qced	249	1	Bioinformatic	bioinformatic	JJ
cord-306414-2dv3qced	249	2	tools	tool	NNS
cord-306414-2dv3qced	249	3	have	have	VBP
cord-306414-2dv3qced	249	4	been	be	VBN
cord-306414-2dv3qced	249	5	developed	develop	VBN
cord-306414-2dv3qced	249	6	to	to	TO
cord-306414-2dv3qced	249	7	enable	enable	VB
cord-306414-2dv3qced	249	8	streamlined	streamline	VBN
cord-306414-2dv3qced	249	9	and	and	CC
cord-306414-2dv3qced	249	10	standardized	standardized	JJ
cord-306414-2dv3qced	249	11	TCR	TCR	NNP
cord-306414-2dv3qced	249	12	-	-	HYPH
cord-306414-2dv3qced	249	13	seq	seq	NNP
cord-306414-2dv3qced	249	14	data	data	NN
cord-306414-2dv3qced	249	15	analysis	analysis	NN
cord-306414-2dv3qced	249	16	and	and	CC
cord-306414-2dv3qced	249	17	have	have	VBP
cord-306414-2dv3qced	249	18	been	be	VBN
cord-306414-2dv3qced	249	19	used	use	VBN
cord-306414-2dv3qced	249	20	by	by	IN
cord-306414-2dv3qced	249	21	our	-PRON-	PRP$
cord-306414-2dv3qced	249	22	group	group	NN
cord-306414-2dv3qced	249	23	and	and	CC
cord-306414-2dv3qced	249	24	others	other	NNS
cord-306414-2dv3qced	249	25	extensively	extensively	RB
cord-306414-2dv3qced	249	26	.	.	.
cord-306414-2dv3qced	250	1	MiXCR	MiXCR	NNP
cord-306414-2dv3qced	251	1	i	i	PRP
cord-306414-2dv3qced	251	2	is	be	VBZ
cord-306414-2dv3qced	251	3	a	a	DT
cord-306414-2dv3qced	251	4	UNIX	UNIX	NNP
cord-306414-2dv3qced	251	5	-	-	HYPH
cord-306414-2dv3qced	251	6	based	base	VBN
cord-306414-2dv3qced	251	7	software	software	NN
cord-306414-2dv3qced	251	8	used	use	VBN
cord-306414-2dv3qced	251	9	to	to	TO
cord-306414-2dv3qced	251	10	identify	identify	VB
cord-306414-2dv3qced	251	11	and	and	CC
cord-306414-2dv3qced	251	12	build	build	VB
cord-306414-2dv3qced	251	13	TCR	TCR	NNP
cord-306414-2dv3qced	251	14	sequences	sequence	NNS
cord-306414-2dv3qced	251	15	using	use	VBG
cord-306414-2dv3qced	251	16	raw	raw	JJ
cord-306414-2dv3qced	251	17	sequencing	sequencing	NN
cord-306414-2dv3qced	251	18	data	datum	NNS
cord-306414-2dv3qced	251	19	[	[	-LRB-
cord-306414-2dv3qced	251	20	77	77	CD
cord-306414-2dv3qced	251	21	]	]	-RRB-
cord-306414-2dv3qced	251	22	.	.	.
cord-306414-2dv3qced	252	1	MiXCR	MiXCR	NNP
cord-306414-2dv3qced	252	2	uses	use	VBZ
cord-306414-2dv3qced	252	3	a	a	DT
cord-306414-2dv3qced	252	4	built	build	VBN
cord-306414-2dv3qced	252	5	-	-	HYPH
cord-306414-2dv3qced	252	6	in	in	RP
cord-306414-2dv3qced	252	7	aligner	aligner	NN
cord-306414-2dv3qced	252	8	and	and	CC
cord-306414-2dv3qced	252	9	reference	reference	NN
cord-306414-2dv3qced	252	10	library	library	NN
cord-306414-2dv3qced	252	11	of	of	IN
cord-306414-2dv3qced	252	12	V	V	NNP
cord-306414-2dv3qced	252	13	,	,	,
cord-306414-2dv3qced	252	14	D	D	NNP
cord-306414-2dv3qced	252	15	,	,	,
cord-306414-2dv3qced	252	16	J	J	NNP
cord-306414-2dv3qced	252	17	,	,	,
cord-306414-2dv3qced	252	18	and	and	CC
cord-306414-2dv3qced	252	19	C	C	NNP
cord-306414-2dv3qced	252	20	segment	segment	NN
cord-306414-2dv3qced	252	21	sequences	sequence	NNS
cord-306414-2dv3qced	252	22	to	to	IN
cord-306414-2dv3qced	252	23	efficiently	efficiently	RB
cord-306414-2dv3qced	252	24	and	and	CC
cord-306414-2dv3qced	252	25	accurately	accurately	RB
cord-306414-2dv3qced	252	26	call	call	VB
cord-306414-2dv3qced	252	27	V	v	NN
cord-306414-2dv3qced	252	28	,	,	,
cord-306414-2dv3qced	252	29	D	D	NNP
cord-306414-2dv3qced	252	30	,	,	,
cord-306414-2dv3qced	252	31	J	J	NNP
cord-306414-2dv3qced	252	32	,	,	,
cord-306414-2dv3qced	252	33	and	and	CC
cord-306414-2dv3qced	252	34	C	c	NN
cord-306414-2dv3qced	252	35	regions	region	NNS
cord-306414-2dv3qced	252	36	from	from	IN
cord-306414-2dv3qced	252	37	millions	million	NNS
cord-306414-2dv3qced	252	38	of	of	IN
cord-306414-2dv3qced	252	39	reads	read	NNS
cord-306414-2dv3qced	252	40	and	and	CC
cord-306414-2dv3qced	252	41	then	then	RB
cord-306414-2dv3qced	252	42	groups	group	NNS
cord-306414-2dv3qced	252	43	similar	similar	JJ
cord-306414-2dv3qced	252	44	reads	read	VBZ
cord-306414-2dv3qced	252	45	together	together	RB
cord-306414-2dv3qced	252	46	to	to	TO
cord-306414-2dv3qced	252	47	build	build	VB
cord-306414-2dv3qced	252	48	a	a	DT
cord-306414-2dv3qced	252	49	final	final	JJ
cord-306414-2dv3qced	252	50	TCR	TCR	NNP
cord-306414-2dv3qced	252	51	sequence	sequence	NN
cord-306414-2dv3qced	252	52	.	.	.
cord-306414-2dv3qced	253	1	The	the	DT
cord-306414-2dv3qced	253	2	assembled	assemble	VBN
cord-306414-2dv3qced	253	3	TCR	TCR	NNP
cord-306414-2dv3qced	253	4	sequences	sequence	NNS
cord-306414-2dv3qced	253	5	along	along	IN
cord-306414-2dv3qced	253	6	with	with	IN
cord-306414-2dv3qced	253	7	V	v	NN
cord-306414-2dv3qced	253	8	,	,	,
cord-306414-2dv3qced	253	9	D	D	NNP
cord-306414-2dv3qced	253	10	,	,	,
cord-306414-2dv3qced	253	11	and	and	CC
cord-306414-2dv3qced	253	12	J	J	NNP
cord-306414-2dv3qced	253	13	annotations	annotation	NNS
cord-306414-2dv3qced	253	14	are	be	VBP
cord-306414-2dv3qced	253	15	written	write	VBN
cord-306414-2dv3qced	253	16	into	into	IN
cord-306414-2dv3qced	253	17	a	a	DT
cord-306414-2dv3qced	253	18	text	text	NN
cord-306414-2dv3qced	253	19	-	-	HYPH
cord-306414-2dv3qced	253	20	formatted	format	VBN
cord-306414-2dv3qced	253	21	file	file	NN
cord-306414-2dv3qced	253	22	that	that	WDT
cord-306414-2dv3qced	253	23	can	can	MD
cord-306414-2dv3qced	253	24	be	be	VB
cord-306414-2dv3qced	253	25	used	use	VBN
cord-306414-2dv3qced	253	26	by	by	IN
cord-306414-2dv3qced	253	27	analysis	analysis	NN
cord-306414-2dv3qced	253	28	tools	tool	NNS
cord-306414-2dv3qced	253	29	such	such	JJ
cord-306414-2dv3qced	253	30	as	as	IN
cord-306414-2dv3qced	253	31	VDJTools	VDJTools	NNP
cord-306414-2dv3qced	253	32	ii	ii	NNP
cord-306414-2dv3qced	253	33	to	to	TO
cord-306414-2dv3qced	253	34	characterize	characterize	VB
cord-306414-2dv3qced	253	35	TCR	TCR	NNP
cord-306414-2dv3qced	253	36	-	-	HYPH
cord-306414-2dv3qced	253	37	seq	seq	NNP
cord-306414-2dv3qced	253	38	data	datum	NNS
cord-306414-2dv3qced	253	39	and	and	CC
cord-306414-2dv3qced	253	40	identify	identify	VB
cord-306414-2dv3qced	253	41	changes	change	NNS
cord-306414-2dv3qced	253	42	in	in	IN
cord-306414-2dv3qced	253	43	the	the	DT
cord-306414-2dv3qced	253	44	TCR	TCR	NNP
cord-306414-2dv3qced	253	45	repertoire	repertoire	NN
cord-306414-2dv3qced	253	46	that	that	WDT
cord-306414-2dv3qced	253	47	may	may	MD
cord-306414-2dv3qced	253	48	occur	occur	VB
cord-306414-2dv3qced	253	49	during	during	IN
cord-306414-2dv3qced	253	50	disease	disease	NN
cord-306414-2dv3qced	253	51	progression	progression	NN
cord-306414-2dv3qced	253	52	in	in	IN
cord-306414-2dv3qced	253	53	COVID-19	covid-19	JJ
cord-306414-2dv3qced	253	54	patients	patient	NNS
cord-306414-2dv3qced	253	55	[	[	-LRB-
cord-306414-2dv3qced	253	56	78	78	CD
cord-306414-2dv3qced	253	57	]	]	-RRB-
cord-306414-2dv3qced	253	58	.	.	.
cord-306414-2dv3qced	254	1	Recent	recent	JJ
cord-306414-2dv3qced	254	2	advances	advance	NNS
cord-306414-2dv3qced	254	3	in	in	IN
cord-306414-2dv3qced	254	4	TCR	TCR	NNP
cord-306414-2dv3qced	254	5	-	-	HYPH
cord-306414-2dv3qced	254	6	seq	seq	NNP
cord-306414-2dv3qced	254	7	have	have	VBP
cord-306414-2dv3qced	254	8	provided	provide	VBN
cord-306414-2dv3qced	254	9	evidence	evidence	NN
cord-306414-2dv3qced	254	10	for	for	IN
cord-306414-2dv3qced	254	11	a	a	DT
cord-306414-2dv3qced	254	12	close	close	JJ
cord-306414-2dv3qced	254	13	relationship	relationship	NN
cord-306414-2dv3qced	254	14	between	between	IN
cord-306414-2dv3qced	254	15	TCR	TCR	NNP
cord-306414-2dv3qced	254	16	diversity	diversity	NN
cord-306414-2dv3qced	254	17	and	and	CC
cord-306414-2dv3qced	254	18	immune	immune	JJ
cord-306414-2dv3qced	254	19	responses	response	NNS
cord-306414-2dv3qced	254	20	against	against	IN
cord-306414-2dv3qced	254	21	viral	viral	JJ
cord-306414-2dv3qced	254	22	antigens	antigen	NNS
cord-306414-2dv3qced	254	23	.	.	.
cord-306414-2dv3qced	255	1	Under	under	IN
cord-306414-2dv3qced	255	2	homeostatic	homeostatic	JJ
cord-306414-2dv3qced	255	3	conditions	condition	NNS
cord-306414-2dv3qced	255	4	,	,	,
cord-306414-2dv3qced	255	5	the	the	DT
cord-306414-2dv3qced	255	6	TCR	TCR	NNP
cord-306414-2dv3qced	255	7	repertoire	repertoire	NN
cord-306414-2dv3qced	255	8	is	be	VBZ
cord-306414-2dv3qced	255	9	largely	largely	RB
cord-306414-2dv3qced	255	10	diverse	diverse	JJ
cord-306414-2dv3qced	255	11	and	and	CC
cord-306414-2dv3qced	255	12	polyclonal	polyclonal	JJ
cord-306414-2dv3qced	255	13	.	.	.
cord-306414-2dv3qced	256	1	However	however	RB
cord-306414-2dv3qced	256	2	,	,	,
cord-306414-2dv3qced	256	3	in	in	IN
cord-306414-2dv3qced	256	4	the	the	DT
cord-306414-2dv3qced	256	5	context	context	NN
cord-306414-2dv3qced	256	6	of	of	IN
cord-306414-2dv3qced	256	7	viral	viral	JJ
cord-306414-2dv3qced	256	8	infection	infection	NN
cord-306414-2dv3qced	256	9	,	,	,
cord-306414-2dv3qced	256	10	preferential	preferential	JJ
cord-306414-2dv3qced	256	11	selection	selection	NN
cord-306414-2dv3qced	256	12	of	of	IN
cord-306414-2dv3qced	256	13	T	T	NNP
cord-306414-2dv3qced	256	14	cell	cell	NN
cord-306414-2dv3qced	256	15	clones	clone	NNS
cord-306414-2dv3qced	256	16	can	can	MD
cord-306414-2dv3qced	256	17	contribute	contribute	VB
cord-306414-2dv3qced	256	18	to	to	IN
cord-306414-2dv3qced	256	19	the	the	DT
cord-306414-2dv3qced	256	20	narrowing	narrowing	NN
cord-306414-2dv3qced	256	21	of	of	IN
cord-306414-2dv3qced	256	22	an	an	DT
cord-306414-2dv3qced	256	23	antigen	antigen	NN
cord-306414-2dv3qced	256	24	-	-	HYPH
cord-306414-2dv3qced	256	25	selected	select	VBN
cord-306414-2dv3qced	256	26	TCR	TCR	NNP
cord-306414-2dv3qced	256	27	repertoire	repertoire	NN
cord-306414-2dv3qced	256	28	.	.	.
cord-306414-2dv3qced	257	1	To	to	TO
cord-306414-2dv3qced	257	2	what	what	WDT
cord-306414-2dv3qced	257	3	extent	extent	NN
cord-306414-2dv3qced	257	4	SARS	SARS	NNP
cord-306414-2dv3qced	257	5	-	-	HYPH
cord-306414-2dv3qced	257	6	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	257	7	influences	influence	VBZ
cord-306414-2dv3qced	257	8	the	the	DT
cord-306414-2dv3qced	257	9	TCR	TCR	NNP
cord-306414-2dv3qced	257	10	repertoire	repertoire	NN
cord-306414-2dv3qced	257	11	remains	remain	VBZ
cord-306414-2dv3qced	257	12	to	to	TO
cord-306414-2dv3qced	257	13	be	be	VB
cord-306414-2dv3qced	257	14	assessed	assess	VBN
cord-306414-2dv3qced	257	15	.	.	.
cord-306414-2dv3qced	258	1	In	in	IN
cord-306414-2dv3qced	258	2	addition	addition	NN
cord-306414-2dv3qced	258	3	,	,	,
cord-306414-2dv3qced	258	4	what	what	WDT
cord-306414-2dv3qced	258	5	impact	impact	NN
cord-306414-2dv3qced	259	1	the	the	DT
cord-306414-2dv3qced	259	2	COVID-19	COVID-19	NNP
cord-306414-2dv3qced	259	3	resulting	result	VBG
cord-306414-2dv3qced	259	4	lymphocytopenia	lymphocytopenia	NNP
cord-306414-2dv3qced	259	5	has	have	VBZ
cord-306414-2dv3qced	259	6	on	on	IN
cord-306414-2dv3qced	259	7	the	the	DT
cord-306414-2dv3qced	259	8	TCR	TCR	NNP
cord-306414-2dv3qced	259	9	repertoire	repertoire	NN
cord-306414-2dv3qced	259	10	architecture	architecture	NN
cord-306414-2dv3qced	259	11	,	,	,
cord-306414-2dv3qced	259	12	diversity	diversity	NN
cord-306414-2dv3qced	259	13	,	,	,
cord-306414-2dv3qced	259	14	and	and	CC
cord-306414-2dv3qced	259	15	composition	composition	NN
cord-306414-2dv3qced	259	16	,	,	,
cord-306414-2dv3qced	259	17	and	and	CC
cord-306414-2dv3qced	259	18	how	how	WRB
cord-306414-2dv3qced	259	19	comorbidities	comorbiditie	NNS
cord-306414-2dv3qced	259	20	such	such	JJ
cord-306414-2dv3qced	259	21	as	as	IN
cord-306414-2dv3qced	259	22	diabetes	diabetes	NN
cord-306414-2dv3qced	259	23	,	,	,
cord-306414-2dv3qced	259	24	obesity	obesity	NN
cord-306414-2dv3qced	259	25	,	,	,
cord-306414-2dv3qced	259	26	and	and	CC
cord-306414-2dv3qced	259	27	hypertension	hypertension	NN
cord-306414-2dv3qced	259	28	which	which	WDT
cord-306414-2dv3qced	259	29	are	be	VBP
cord-306414-2dv3qced	259	30	implicated	implicate	VBN
cord-306414-2dv3qced	259	31	in	in	IN
cord-306414-2dv3qced	259	32	COVID-19	covid-19	JJ
cord-306414-2dv3qced	259	33	severity	severity	NN
cord-306414-2dv3qced	259	34	may	may	MD
cord-306414-2dv3qced	259	35	influence	influence	VB
cord-306414-2dv3qced	259	36	the	the	DT
cord-306414-2dv3qced	259	37	TCR	TCR	NNP
cord-306414-2dv3qced	259	38	repertoire	repertoire	NN
cord-306414-2dv3qced	259	39	,	,	,
cord-306414-2dv3qced	259	40	are	be	VBP
cord-306414-2dv3qced	259	41	questions	question	NNS
cord-306414-2dv3qced	259	42	that	that	WDT
cord-306414-2dv3qced	259	43	warrant	warrant	VBP
cord-306414-2dv3qced	259	44	attention	attention	NN
cord-306414-2dv3qced	259	45	(	(	-LRB-
cord-306414-2dv3qced	259	46	see	see	VB
cord-306414-2dv3qced	259	47	Outstanding	Outstanding	NNP
cord-306414-2dv3qced	259	48	Questions	Questions	NNPS
cord-306414-2dv3qced	259	49	)	)	-RRB-
cord-306414-2dv3qced	259	50	.	.	.
cord-306414-2dv3qced	260	1	Studying	study	VBG
cord-306414-2dv3qced	260	2	the	the	DT
cord-306414-2dv3qced	260	3	TCR	TCR	NNP
cord-306414-2dv3qced	260	4	repertoire	repertoire	NN
cord-306414-2dv3qced	260	5	may	may	MD
cord-306414-2dv3qced	260	6	also	also	RB
cord-306414-2dv3qced	260	7	reveal	reveal	VB
cord-306414-2dv3qced	260	8	potential	potential	JJ
cord-306414-2dv3qced	260	9	public	public	JJ
cord-306414-2dv3qced	260	10	TCRs	tcr	NNS
cord-306414-2dv3qced	260	11	,	,	,
cord-306414-2dv3qced	260	12	which	which	WDT
cord-306414-2dv3qced	260	13	may	may	MD
cord-306414-2dv3qced	260	14	allow	allow	VB
cord-306414-2dv3qced	260	15	us	-PRON-	PRP
cord-306414-2dv3qced	260	16	to	to	TO
cord-306414-2dv3qced	260	17	track	track	VB
cord-306414-2dv3qced	260	18	infection	infection	NN
cord-306414-2dv3qced	260	19	as	as	RB
cord-306414-2dv3qced	260	20	well	well	RB
cord-306414-2dv3qced	260	21	as	as	IN
cord-306414-2dv3qced	260	22	understand	understand	VB
cord-306414-2dv3qced	260	23	immunity	immunity	NN
cord-306414-2dv3qced	260	24	against	against	IN
cord-306414-2dv3qced	260	25	this	this	DT
cord-306414-2dv3qced	260	26	infection	infection	NN
cord-306414-2dv3qced	260	27	.	.	.
cord-306414-2dv3qced	261	1	In	in	IN
cord-306414-2dv3qced	261	2	line	line	NN
cord-306414-2dv3qced	261	3	with	with	IN
cord-306414-2dv3qced	261	4	our	-PRON-	PRP$
cord-306414-2dv3qced	261	5	opinion	opinion	NN
cord-306414-2dv3qced	261	6	,	,	,
cord-306414-2dv3qced	261	7	several	several	JJ
cord-306414-2dv3qced	261	8	efforts	effort	NNS
cord-306414-2dv3qced	261	9	are	be	VBP
cord-306414-2dv3qced	261	10	on	on	IN
cord-306414-2dv3qced	261	11	the	the	DT
cord-306414-2dv3qced	261	12	way	way	NN
cord-306414-2dv3qced	261	13	to	to	TO
cord-306414-2dv3qced	261	14	perform	perform	VB
cord-306414-2dv3qced	261	15	TCR	TCR	NNP
cord-306414-2dv3qced	261	16	analysis	analysis	NN
cord-306414-2dv3qced	261	17	in	in	IN
cord-306414-2dv3qced	261	18	COVID-19	COVID-19	NNP
cord-306414-2dv3qced	261	19	patients	patient	NNS
cord-306414-2dv3qced	261	20	.	.	.
cord-306414-2dv3qced	262	1	A	a	DT
cord-306414-2dv3qced	262	2	recent	recent	JJ
cord-306414-2dv3qced	262	3	study	study	NN
cord-306414-2dv3qced	262	4	has	have	VBZ
cord-306414-2dv3qced	262	5	reported	report	VBN
cord-306414-2dv3qced	262	6	a	a	DT
cord-306414-2dv3qced	262	7	longitudinal	longitudinal	JJ
cord-306414-2dv3qced	262	8	high	high	JJ
cord-306414-2dv3qced	262	9	-	-	HYPH
cord-306414-2dv3qced	262	10	throughput	throughput	NN
cord-306414-2dv3qced	262	11	TCR	TCR	NNP
cord-306414-2dv3qced	262	12	-	-	HYPH
cord-306414-2dv3qced	262	13	seq	seq	NNP
cord-306414-2dv3qced	262	14	to	to	TO
cord-306414-2dv3qced	262	15	track	track	VB
cord-306414-2dv3qced	262	16	changes	change	NNS
cord-306414-2dv3qced	262	17	in	in	IN
cord-306414-2dv3qced	262	18	the	the	DT
cord-306414-2dv3qced	262	19	T	T	NNP
cord-306414-2dv3qced	262	20	cell	cell	NN
cord-306414-2dv3qced	262	21	repertoire	repertoire	NN
cord-306414-2dv3qced	262	22	following	follow	VBG
cord-306414-2dv3qced	262	23	two	two	CD
cord-306414-2dv3qced	262	24	mild	mild	JJ
cord-306414-2dv3qced	262	25	cases	case	NNS
cord-306414-2dv3qced	262	26	of	of	IN
cord-306414-2dv3qced	262	27	COVID-19	covid-19	JJ
cord-306414-2dv3qced	262	28	infection	infection	NN
cord-306414-2dv3qced	262	29	[	[	-LRB-
cord-306414-2dv3qced	262	30	79	79	CD
cord-306414-2dv3qced	262	31	]	]	-RRB-
cord-306414-2dv3qced	262	32	.	.	.
cord-306414-2dv3qced	263	1	In	in	IN
cord-306414-2dv3qced	263	2	addition	addition	NN
cord-306414-2dv3qced	263	3	,	,	,
cord-306414-2dv3qced	263	4	clinical	clinical	JJ
cord-306414-2dv3qced	263	5	trials	trial	NNS
cord-306414-2dv3qced	263	6	(	(	-LRB-
cord-306414-2dv3qced	263	7	clinical	clinical	JJ
cord-306414-2dv3qced	263	8	trial	trial	NN
cord-306414-2dv3qced	263	9	numbers	number	NNS
cord-306414-2dv3qced	263	10	iii	iii	NN
cord-306414-2dv3qced	263	11	:	:	:
cord-306414-2dv3qced	264	1	NCT04379466	NCT04379466	NNP
cord-306414-2dv3qced	264	2	and	and	CC
cord-306414-2dv3qced	264	3	NCT04362865	NCT04362865	NNP
cord-306414-2dv3qced	264	4	)	)	-RRB-
cord-306414-2dv3qced	264	5	have	have	VBP
cord-306414-2dv3qced	264	6	been	be	VBN
cord-306414-2dv3qced	264	7	initiated	initiate	VBN
cord-306414-2dv3qced	264	8	to	to	TO
cord-306414-2dv3qced	264	9	examine	examine	VB
cord-306414-2dv3qced	264	10	the	the	DT
cord-306414-2dv3qced	264	11	immune	immune	JJ
cord-306414-2dv3qced	264	12	repertoire	repertoire	NN
cord-306414-2dv3qced	264	13	in	in	IN
cord-306414-2dv3qced	264	14	COVID-19	COVID-19	NNP
cord-306414-2dv3qced	264	15	patients	patient	NNS
cord-306414-2dv3qced	264	16	.	.	.
cord-306414-2dv3qced	265	1	The	the	DT
cord-306414-2dv3qced	265	2	NCT04362865	NCT04362865	NNP
cord-306414-2dv3qced	265	3	trial	trial	NN
cord-306414-2dv3qced	265	4	,	,	,
cord-306414-2dv3qced	265	5	sponsored	sponsor	VBN
cord-306414-2dv3qced	265	6	by	by	IN
cord-306414-2dv3qced	265	7	the	the	DT
cord-306414-2dv3qced	265	8	National	National	NNP
cord-306414-2dv3qced	265	9	Institute	Institute	NNP
cord-306414-2dv3qced	265	10	of	of	IN
cord-306414-2dv3qced	265	11	Health	Health	NNP
cord-306414-2dv3qced	265	12	,	,	,
cord-306414-2dv3qced	265	13	is	be	VBZ
cord-306414-2dv3qced	265	14	particularly	particularly	RB
cord-306414-2dv3qced	265	15	interesting	interesting	JJ
cord-306414-2dv3qced	265	16	as	as	IN
cord-306414-2dv3qced	265	17	it	-PRON-	PRP
cord-306414-2dv3qced	265	18	aims	aim	VBZ
cord-306414-2dv3qced	265	19	to	to	TO
cord-306414-2dv3qced	265	20	investigate	investigate	VB
cord-306414-2dv3qced	265	21	both	both	CC
cord-306414-2dv3qced	265	22	the	the	DT
cord-306414-2dv3qced	265	23	B	B	NNP
cord-306414-2dv3qced	265	24	and	and	CC
cord-306414-2dv3qced	265	25	T	T	NNP
cord-306414-2dv3qced	265	26	cell	cell	NN
cord-306414-2dv3qced	265	27	repertoire	repertoire	NN
cord-306414-2dv3qced	265	28	and	and	CC
cord-306414-2dv3qced	265	29	immune	immune	JJ
cord-306414-2dv3qced	265	30	response	response	NN
cord-306414-2dv3qced	265	31	in	in	IN
cord-306414-2dv3qced	265	32	patients	patient	NNS
cord-306414-2dv3qced	265	33	with	with	IN
cord-306414-2dv3qced	265	34	acute	acute	JJ
cord-306414-2dv3qced	265	35	and	and	CC
cord-306414-2dv3qced	265	36	resolved	resolve	VBD
cord-306414-2dv3qced	265	37	COVID-19	covid-19	JJ
cord-306414-2dv3qced	265	38	infection	infection	NN
cord-306414-2dv3qced	265	39	.	.	.
cord-306414-2dv3qced	266	1	We	-PRON-	PRP
cord-306414-2dv3qced	266	2	should	should	MD
cord-306414-2dv3qced	266	3	emphasize	emphasize	VB
cord-306414-2dv3qced	266	4	that	that	IN
cord-306414-2dv3qced	266	5	the	the	DT
cord-306414-2dv3qced	266	6	B	B	NNP
cord-306414-2dv3qced	266	7	cell	cell	NN
cord-306414-2dv3qced	266	8	immunoglobulin	immunoglobulin	NN
cord-306414-2dv3qced	266	9	repertoire	repertoire	NN
cord-306414-2dv3qced	266	10	analysis	analysis	NN
cord-306414-2dv3qced	266	11	is	be	VBZ
cord-306414-2dv3qced	266	12	also	also	RB
cord-306414-2dv3qced	266	13	a	a	DT
cord-306414-2dv3qced	266	14	significant	significant	JJ
cord-306414-2dv3qced	266	15	and	and	CC
cord-306414-2dv3qced	266	16	an	an	DT
cord-306414-2dv3qced	266	17	urgently	urgently	RB
cord-306414-2dv3qced	266	18	needed	need	VBN
cord-306414-2dv3qced	266	19	task	task	NN
cord-306414-2dv3qced	266	20	.	.	.
cord-306414-2dv3qced	267	1	Indeed	indeed	RB
cord-306414-2dv3qced	267	2	,	,	,
cord-306414-2dv3qced	267	3	a	a	DT
cord-306414-2dv3qced	267	4	recent	recent	JJ
cord-306414-2dv3qced	267	5	study	study	NN
cord-306414-2dv3qced	267	6	has	have	VBZ
cord-306414-2dv3qced	267	7	applied	apply	VBN
cord-306414-2dv3qced	267	8	a	a	DT
cord-306414-2dv3qced	267	9	single	single	JJ
cord-306414-2dv3qced	267	10	-	-	HYPH
cord-306414-2dv3qced	267	11	cell	cell	NN
cord-306414-2dv3qced	267	12	immune	immune	JJ
cord-306414-2dv3qced	267	13	profiling	profiling	NN
cord-306414-2dv3qced	267	14	approach	approach	NN
cord-306414-2dv3qced	267	15	that	that	WDT
cord-306414-2dv3qced	267	16	combines	combine	VBZ
cord-306414-2dv3qced	267	17	single	single	JJ
cord-306414-2dv3qced	267	18	-	-	HYPH
cord-306414-2dv3qced	267	19	cell	cell	NN
cord-306414-2dv3qced	267	20	transcriptomic	transcriptomic	JJ
cord-306414-2dv3qced	267	21	analysis	analysis	NN
cord-306414-2dv3qced	267	22	with	with	IN
cord-306414-2dv3qced	267	23	single	single	JJ
cord-306414-2dv3qced	267	24	-	-	HYPH
cord-306414-2dv3qced	267	25	cell	cell	NN
cord-306414-2dv3qced	267	26	TCR	TCR	NNP
cord-306414-2dv3qced	267	27	and	and	CC
cord-306414-2dv3qced	267	28	B	B	NNP
cord-306414-2dv3qced	267	29	cell	cell	NN
cord-306414-2dv3qced	267	30	receptor	receptor	NN
cord-306414-2dv3qced	267	31	(	(	-LRB-
cord-306414-2dv3qced	267	32	BCR	BCR	NNP
cord-306414-2dv3qced	267	33	)	)	-RRB-
cord-306414-2dv3qced	267	34	sequencing	sequencing	NN
cord-306414-2dv3qced	267	35	technologies	technology	NNS
cord-306414-2dv3qced	267	36	to	to	TO
cord-306414-2dv3qced	267	37	examine	examine	VB
cord-306414-2dv3qced	267	38	the	the	DT
cord-306414-2dv3qced	267	39	cellular	cellular	JJ
cord-306414-2dv3qced	267	40	context	context	NN
cord-306414-2dv3qced	267	41	of	of	IN
cord-306414-2dv3qced	267	42	the	the	DT
cord-306414-2dv3qced	267	43	adaptive	adaptive	JJ
cord-306414-2dv3qced	267	44	immune	immune	JJ
cord-306414-2dv3qced	267	45	response	response	NN
cord-306414-2dv3qced	267	46	and	and	CC
cord-306414-2dv3qced	267	47	immune	immune	JJ
cord-306414-2dv3qced	267	48	repertoires	repertoire	NNS
cord-306414-2dv3qced	267	49	of	of	IN
cord-306414-2dv3qced	267	50	T	t	NN
cord-306414-2dv3qced	267	51	and	and	CC
cord-306414-2dv3qced	267	52	B	b	NN
cord-306414-2dv3qced	267	53	cells	cell	NNS
cord-306414-2dv3qced	267	54	in	in	IN
cord-306414-2dv3qced	267	55	blood	blood	NN
cord-306414-2dv3qced	267	56	samples	sample	NNS
cord-306414-2dv3qced	267	57	of	of	IN
cord-306414-2dv3qced	267	58	How	how	WRB
cord-306414-2dv3qced	267	59	does	do	VBZ
cord-306414-2dv3qced	267	60	SARS	SARS	NNP
cord-306414-2dv3qced	267	61	-	-	HYPH
cord-306414-2dv3qced	267	62	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	267	63	influence	influence	VB
cord-306414-2dv3qced	267	64	the	the	DT
cord-306414-2dv3qced	267	65	TCR	TCR	NNP
cord-306414-2dv3qced	267	66	repertoire	repertoire	NN
cord-306414-2dv3qced	267	67	?	?	.
cord-306414-2dv3qced	268	1	How	how	WRB
cord-306414-2dv3qced	268	2	and	and	CC
cord-306414-2dv3qced	268	3	which	which	WDT
cord-306414-2dv3qced	268	4	characteristics	characteristic	NNS
cord-306414-2dv3qced	268	5	of	of	IN
cord-306414-2dv3qced	268	6	the	the	DT
cord-306414-2dv3qced	268	7	TCR	TCR	NNP
cord-306414-2dv3qced	268	8	repertoire	repertoire	NN
cord-306414-2dv3qced	268	9	may	may	MD
cord-306414-2dv3qced	268	10	explain	explain	VB
cord-306414-2dv3qced	268	11	the	the	DT
cord-306414-2dv3qced	268	12	disproportional	disproportional	JJ
cord-306414-2dv3qced	268	13	risk	risk	NN
cord-306414-2dv3qced	268	14	of	of	IN
cord-306414-2dv3qced	268	15	COVID-19	covid-19	DT
cord-306414-2dv3qced	268	16	in	in	IN
cord-306414-2dv3qced	268	17	older	old	JJR
cord-306414-2dv3qced	268	18	population	population	NN
cord-306414-2dv3qced	268	19	?	?	.
cord-306414-2dv3qced	269	1	What	what	WDT
cord-306414-2dv3qced	269	2	impact	impact	NN
cord-306414-2dv3qced	269	3	does	do	VBZ
cord-306414-2dv3qced	269	4	the	the	DT
cord-306414-2dv3qced	269	5	lymphocytopenia	lymphocytopenia	NNP
cord-306414-2dv3qced	269	6	in	in	IN
cord-306414-2dv3qced	269	7	COVID-19	COVID-19	NNP
cord-306414-2dv3qced	269	8	have	have	VBP
cord-306414-2dv3qced	269	9	on	on	IN
cord-306414-2dv3qced	269	10	the	the	DT
cord-306414-2dv3qced	269	11	TCR	TCR	NNP
cord-306414-2dv3qced	269	12	repertoire	repertoire	NN
cord-306414-2dv3qced	269	13	architecture	architecture	NN
cord-306414-2dv3qced	269	14	,	,	,
cord-306414-2dv3qced	269	15	diversity	diversity	NN
cord-306414-2dv3qced	269	16	,	,	,
cord-306414-2dv3qced	269	17	and	and	CC
cord-306414-2dv3qced	269	18	composition	composition	NN
cord-306414-2dv3qced	269	19	?	?	.
cord-306414-2dv3qced	270	1	How	how	WRB
cord-306414-2dv3qced	270	2	does	do	VBZ
cord-306414-2dv3qced	270	3	genetic	genetic	JJ
cord-306414-2dv3qced	270	4	diversity	diversity	NN
cord-306414-2dv3qced	270	5	in	in	IN
cord-306414-2dv3qced	270	6	the	the	DT
cord-306414-2dv3qced	270	7	HLAs	HLAs	NNP
cord-306414-2dv3qced	270	8	contribute	contribute	VB
cord-306414-2dv3qced	270	9	to	to	IN
cord-306414-2dv3qced	270	10	the	the	DT
cord-306414-2dv3qced	270	11	SARS-	sars-	NN
cord-306414-2dv3qced	271	1	CoV-2-specific	CoV-2-specific	NNP
cord-306414-2dv3qced	271	2	TCR	TCR	NNP
cord-306414-2dv3qced	271	3	repertoire	repertoire	NN
cord-306414-2dv3qced	271	4	and	and	CC
cord-306414-2dv3qced	271	5	,	,	,
cord-306414-2dv3qced	271	6	potentially	potentially	RB
cord-306414-2dv3qced	271	7	,	,	,
cord-306414-2dv3qced	271	8	the	the	DT
cord-306414-2dv3qced	271	9	immune	immune	JJ
cord-306414-2dv3qced	271	10	response	response	NN
cord-306414-2dv3qced	271	11	?	?	.
cord-306414-2dv3qced	272	1	How	how	WRB
cord-306414-2dv3qced	272	2	might	may	MD
cord-306414-2dv3qced	272	3	factors	factor	NNS
cord-306414-2dv3qced	272	4	such	such	JJ
cord-306414-2dv3qced	272	5	as	as	IN
cord-306414-2dv3qced	272	6	comorbidities	comorbiditie	NNS
cord-306414-2dv3qced	272	7	influence	influence	VBP
cord-306414-2dv3qced	272	8	the	the	DT
cord-306414-2dv3qced	272	9	TCR	TCR	NNP
cord-306414-2dv3qced	272	10	repertoire	repertoire	NN
cord-306414-2dv3qced	272	11	in	in	IN
cord-306414-2dv3qced	272	12	COVID-19	COVID-19	NNP
cord-306414-2dv3qced	272	13	patients	patient	NNS
cord-306414-2dv3qced	272	14	?	?	.
cord-306414-2dv3qced	273	1	COVID-19	covid-19	JJ
cord-306414-2dv3qced	273	2	patients	patient	NNS
cord-306414-2dv3qced	273	3	[	[	-LRB-
cord-306414-2dv3qced	273	4	54	54	CD
cord-306414-2dv3qced	273	5	]	]	-RRB-
cord-306414-2dv3qced	273	6	.	.	.
cord-306414-2dv3qced	274	1	We	-PRON-	PRP
cord-306414-2dv3qced	274	2	foresee	foresee	VBP
cord-306414-2dv3qced	274	3	that	that	IN
cord-306414-2dv3qced	274	4	other	other	JJ
cord-306414-2dv3qced	274	5	platforms	platform	NNS
cord-306414-2dv3qced	274	6	can	can	MD
cord-306414-2dv3qced	274	7	also	also	RB
cord-306414-2dv3qced	274	8	provide	provide	VB
cord-306414-2dv3qced	274	9	valuable	valuable	JJ
cord-306414-2dv3qced	274	10	data	datum	NNS
cord-306414-2dv3qced	274	11	,	,	,
cord-306414-2dv3qced	274	12	such	such	JJ
cord-306414-2dv3qced	274	13	as	as	IN
cord-306414-2dv3qced	274	14	CyTOF	CyTOF	NNP
cord-306414-2dv3qced	274	15	mass	mass	NN
cord-306414-2dv3qced	274	16	cytometry	cytometry	NN
cord-306414-2dv3qced	274	17	and	and	CC
cord-306414-2dv3qced	274	18	the	the	DT
cord-306414-2dv3qced	274	19	10×Genomics	10×genomics	CD
cord-306414-2dv3qced	274	20	iv	iv	NNP
cord-306414-2dv3qced	274	21	immune	immune	JJ
cord-306414-2dv3qced	274	22	profiling	profiling	NN
cord-306414-2dv3qced	274	23	platform	platform	NN
cord-306414-2dv3qced	274	24	that	that	WDT
cord-306414-2dv3qced	274	25	utilizes	utilize	VBZ
cord-306414-2dv3qced	274	26	DNAbarcoded	dnabarcoded	JJ
cord-306414-2dv3qced	274	27	peptide	peptide	NNP
cord-306414-2dv3qced	274	28	-	-	HYPH
cord-306414-2dv3qced	274	29	MHC	MHC	NNP
cord-306414-2dv3qced	274	30	(	(	-LRB-
cord-306414-2dv3qced	274	31	pMHC	pmhc	NN
cord-306414-2dv3qced	274	32	)	)	-RRB-
cord-306414-2dv3qced	274	33	multimers	multimer	NNS
cord-306414-2dv3qced	274	34	and	and	CC
cord-306414-2dv3qced	274	35	antibodies	antibody	NNS
cord-306414-2dv3qced	274	36	conjugated	conjugate	VBN
cord-306414-2dv3qced	274	37	to	to	IN
cord-306414-2dv3qced	274	38	barcodes	barcode	NNS
cord-306414-2dv3qced	274	39	to	to	TO
cord-306414-2dv3qced	274	40	dissect	dissect	VB
cord-306414-2dv3qced	274	41	the	the	DT
cord-306414-2dv3qced	274	42	immune	immune	JJ
cord-306414-2dv3qced	274	43	repertoire	repertoire	NN
cord-306414-2dv3qced	274	44	in	in	IN
cord-306414-2dv3qced	274	45	the	the	DT
cord-306414-2dv3qced	274	46	setting	setting	NN
cord-306414-2dv3qced	274	47	of	of	IN
cord-306414-2dv3qced	274	48	COVID-19	covid-19	NN
cord-306414-2dv3qced	274	49	.	.	.
cord-306414-2dv3qced	275	1	These	these	DT
cord-306414-2dv3qced	275	2	analyses	analysis	NNS
cord-306414-2dv3qced	275	3	should	should	MD
cord-306414-2dv3qced	275	4	reveal	reveal	VB
cord-306414-2dv3qced	275	5	clonality	clonality	NN
cord-306414-2dv3qced	275	6	,	,	,
cord-306414-2dv3qced	275	7	diversity	diversity	NN
cord-306414-2dv3qced	275	8	,	,	,
cord-306414-2dv3qced	275	9	antigen	antigen	NN
cord-306414-2dv3qced	275	10	specificity	specificity	NN
cord-306414-2dv3qced	275	11	,	,	,
cord-306414-2dv3qced	275	12	and	and	CC
cord-306414-2dv3qced	275	13	cellular	cellular	JJ
cord-306414-2dv3qced	275	14	context	context	NN
cord-306414-2dv3qced	275	15	;	;	:
cord-306414-2dv3qced	275	16	and	and	CC
cord-306414-2dv3qced	275	17	pair	pair	VB
cord-306414-2dv3qced	275	18	α	α	NN
cord-306414-2dv3qced	275	19	and	and	CC
cord-306414-2dv3qced	275	20	β	β	NN
cord-306414-2dv3qced	275	21	chain	chain	NN
cord-306414-2dv3qced	275	22	TCR	TCR	NNP
cord-306414-2dv3qced	275	23	sequences	sequence	NNS
cord-306414-2dv3qced	275	24	from	from	IN
cord-306414-2dv3qced	275	25	individual	individual	JJ
cord-306414-2dv3qced	275	26	T	t	NN
cord-306414-2dv3qced	275	27	cells	cell	NNS
cord-306414-2dv3qced	275	28	.	.	.
cord-306414-2dv3qced	276	1	It	-PRON-	PRP
cord-306414-2dv3qced	276	2	also	also	RB
cord-306414-2dv3qced	276	3	allows	allow	VBZ
cord-306414-2dv3qced	276	4	for	for	IN
cord-306414-2dv3qced	276	5	pairing	pair	VBG
cord-306414-2dv3qced	276	6	heavy	heavy	JJ
cord-306414-2dv3qced	276	7	and	and	CC
cord-306414-2dv3qced	276	8	light	light	JJ
cord-306414-2dv3qced	276	9	chain	chain	NN
cord-306414-2dv3qced	276	10	immunoglobulin	immunoglobulin	NN
cord-306414-2dv3qced	276	11	sequences	sequence	NNS
cord-306414-2dv3qced	276	12	from	from	IN
cord-306414-2dv3qced	276	13	individual	individual	JJ
cord-306414-2dv3qced	276	14	B	b	NN
cord-306414-2dv3qced	276	15	cells	cell	NNS
cord-306414-2dv3qced	276	16	.	.	.
cord-306414-2dv3qced	277	1	These	these	DT
cord-306414-2dv3qced	277	2	data	datum	NNS
cord-306414-2dv3qced	277	3	,	,	,
cord-306414-2dv3qced	277	4	combined	combine	VBN
cord-306414-2dv3qced	277	5	with	with	IN
cord-306414-2dv3qced	277	6	sophisticated	sophisticated	JJ
cord-306414-2dv3qced	277	7	computational	computational	JJ
cord-306414-2dv3qced	277	8	methods	method	NNS
cord-306414-2dv3qced	277	9	,	,	,
cord-306414-2dv3qced	277	10	will	will	MD
cord-306414-2dv3qced	277	11	enable	enable	VB
cord-306414-2dv3qced	277	12	the	the	DT
cord-306414-2dv3qced	277	13	identification	identification	NN
cord-306414-2dv3qced	277	14	of	of	IN
cord-306414-2dv3qced	277	15	the	the	DT
cord-306414-2dv3qced	277	16	paired	pair	VBN
cord-306414-2dv3qced	277	17	TCR	TCR	NNP
cord-306414-2dv3qced	277	18	α	α	NNP
cord-306414-2dv3qced	277	19	and	and	CC
cord-306414-2dv3qced	277	20	β	β	NN
cord-306414-2dv3qced	277	21	chain	chain	NN
cord-306414-2dv3qced	277	22	sequences	sequence	NNS
cord-306414-2dv3qced	277	23	with	with	IN
cord-306414-2dv3qced	277	24	TCR	TCR	NNP
cord-306414-2dv3qced	277	25	-	-	HYPH
cord-306414-2dv3qced	277	26	pMHC	pmhc	JJ
cord-306414-2dv3qced	277	27	specificity	specificity	NN
cord-306414-2dv3qced	277	28	corresponding	correspond	VBG
cord-306414-2dv3qced	277	29	to	to	IN
cord-306414-2dv3qced	277	30	SARS	SARS	NNP
cord-306414-2dv3qced	277	31	-	-	HYPH
cord-306414-2dv3qced	277	32	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	277	33	.	.	.
cord-306414-2dv3qced	278	1	More	more	RBR
cord-306414-2dv3qced	278	2	importantly	importantly	RB
cord-306414-2dv3qced	278	3	it	-PRON-	PRP
cord-306414-2dv3qced	278	4	will	will	MD
cord-306414-2dv3qced	278	5	simultaneously	simultaneously	RB
cord-306414-2dv3qced	278	6	measure	measure	VB
cord-306414-2dv3qced	278	7	cell	cell	NN
cord-306414-2dv3qced	278	8	surface	surface	NN
cord-306414-2dv3qced	278	9	protein	protein	NN
cord-306414-2dv3qced	278	10	expression	expression	NN
cord-306414-2dv3qced	278	11	with	with	IN
cord-306414-2dv3qced	278	12	gene	gene	NN
cord-306414-2dv3qced	278	13	expression	expression	NN
cord-306414-2dv3qced	278	14	and	and	CC
cord-306414-2dv3qced	278	15	uncover	uncover	VB
cord-306414-2dv3qced	278	16	meaningful	meaningful	JJ
cord-306414-2dv3qced	278	17	details	detail	NNS
cord-306414-2dv3qced	278	18	related	relate	VBN
cord-306414-2dv3qced	278	19	to	to	IN
cord-306414-2dv3qced	278	20	the	the	DT
cord-306414-2dv3qced	278	21	mechanisms	mechanism	NNS
cord-306414-2dv3qced	278	22	contributing	contribute	VBG
cord-306414-2dv3qced	278	23	to	to	IN
cord-306414-2dv3qced	278	24	the	the	DT
cord-306414-2dv3qced	278	25	pathology	pathology	NN
cord-306414-2dv3qced	278	26	of	of	IN
cord-306414-2dv3qced	278	27	this	this	DT
cord-306414-2dv3qced	278	28	infection	infection	NN
cord-306414-2dv3qced	278	29	and	and	CC
cord-306414-2dv3qced	278	30	the	the	DT
cord-306414-2dv3qced	278	31	patient	patient	NN
cord-306414-2dv3qced	278	32	's	's	POS
cord-306414-2dv3qced	278	33	clinical	clinical	JJ
cord-306414-2dv3qced	278	34	outcome	outcome	NN
cord-306414-2dv3qced	278	35	[	[	-LRB-
cord-306414-2dv3qced	278	36	57	57	CD
cord-306414-2dv3qced	278	37	]	]	-RRB-
cord-306414-2dv3qced	278	38	.	.	.
cord-306414-2dv3qced	279	1	Together	together	RB
cord-306414-2dv3qced	279	2	,	,	,
cord-306414-2dv3qced	279	3	these	these	DT
cord-306414-2dv3qced	279	4	technologies	technology	NNS
cord-306414-2dv3qced	279	5	can	can	MD
cord-306414-2dv3qced	279	6	be	be	VB
cord-306414-2dv3qced	279	7	leveraged	leverage	VBN
cord-306414-2dv3qced	279	8	to	to	TO
cord-306414-2dv3qced	279	9	monitor	monitor	VB
cord-306414-2dv3qced	279	10	adaptive	adaptive	JJ
cord-306414-2dv3qced	279	11	immune	immune	JJ
cord-306414-2dv3qced	279	12	responses	response	NNS
cord-306414-2dv3qced	279	13	in	in	IN
cord-306414-2dv3qced	279	14	COVID-19	covid-19	JJ
cord-306414-2dv3qced	279	15	patients	patient	NNS
cord-306414-2dv3qced	279	16	and	and	CC
cord-306414-2dv3qced	279	17	guide	guide	VB
cord-306414-2dv3qced	279	18	future	future	JJ
cord-306414-2dv3qced	279	19	SARS	SARS	NNP
cord-306414-2dv3qced	279	20	-	-	HYPH
cord-306414-2dv3qced	279	21	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	279	22	immunotherapy	immunotherapy	NN
cord-306414-2dv3qced	279	23	development	development	NN
cord-306414-2dv3qced	279	24	.	.	.
cord-306414-2dv3qced	280	1	Which	which	WDT
cord-306414-2dv3qced	280	2	characteristics	characteristic	NNS
cord-306414-2dv3qced	280	3	of	of	IN
cord-306414-2dv3qced	280	4	the	the	DT
cord-306414-2dv3qced	280	5	TCR	TCR	NNP
cord-306414-2dv3qced	280	6	repertoire	repertoire	NN
cord-306414-2dv3qced	280	7	may	may	MD
cord-306414-2dv3qced	280	8	explain	explain	VB
cord-306414-2dv3qced	280	9	the	the	DT
cord-306414-2dv3qced	280	10	disproportional	disproportional	JJ
cord-306414-2dv3qced	280	11	risk	risk	NN
cord-306414-2dv3qced	280	12	of	of	IN
cord-306414-2dv3qced	280	13	COVID-19	covid-19	DT
cord-306414-2dv3qced	280	14	in	in	IN
cord-306414-2dv3qced	280	15	older	old	JJR
cord-306414-2dv3qced	280	16	population	population	NN
cord-306414-2dv3qced	280	17	and	and	CC
cord-306414-2dv3qced	280	18	how	how	WRB
cord-306414-2dv3qced	280	19	genetic	genetic	JJ
cord-306414-2dv3qced	280	20	diversity	diversity	NN
cord-306414-2dv3qced	280	21	in	in	IN
cord-306414-2dv3qced	280	22	the	the	DT
cord-306414-2dv3qced	280	23	HLAs	HLAs	NNP
cord-306414-2dv3qced	280	24	contribute	contribute	VB
cord-306414-2dv3qced	280	25	to	to	IN
cord-306414-2dv3qced	280	26	the	the	DT
cord-306414-2dv3qced	280	27	SARS-	sars-	NN
cord-306414-2dv3qced	281	1	CoV-2-specific	CoV-2-specific	NNP
cord-306414-2dv3qced	281	2	TCR	TCR	NNP
cord-306414-2dv3qced	281	3	repertoire	repertoire	NN
cord-306414-2dv3qced	281	4	and	and	CC
cord-306414-2dv3qced	281	5	potentially	potentially	RB
cord-306414-2dv3qced	281	6	the	the	DT
cord-306414-2dv3qced	281	7	immune	immune	JJ
cord-306414-2dv3qced	281	8	response	response	NN
cord-306414-2dv3qced	281	9	are	be	VBP
cord-306414-2dv3qced	281	10	some	some	DT
cord-306414-2dv3qced	281	11	of	of	IN
cord-306414-2dv3qced	281	12	many	many	JJ
cord-306414-2dv3qced	281	13	outstanding	outstanding	JJ
cord-306414-2dv3qced	281	14	questions	question	NNS
cord-306414-2dv3qced	281	15	to	to	TO
cord-306414-2dv3qced	281	16	be	be	VB
cord-306414-2dv3qced	281	17	tackled	tackle	VBN
cord-306414-2dv3qced	281	18	(	(	-LRB-
cord-306414-2dv3qced	281	19	see	see	VB
cord-306414-2dv3qced	281	20	Outstanding	Outstanding	NNP
cord-306414-2dv3qced	281	21	Questions	Questions	NNPS
cord-306414-2dv3qced	281	22	)	)	-RRB-
cord-306414-2dv3qced	281	23	.	.	.
cord-306414-2dv3qced	282	1	COVID-19	covid-19	JJ
cord-306414-2dv3qced	282	2	infection	infection	NN
cord-306414-2dv3qced	282	3	:	:	:
cord-306414-2dv3qced	282	4	the	the	DT
cord-306414-2dv3qced	282	5	perspectives	perspective	NNS
cord-306414-2dv3qced	282	6	on	on	IN
cord-306414-2dv3qced	282	7	immune	immune	JJ
cord-306414-2dv3qced	282	8	responses	response	NNS
cord-306414-2dv3qced	282	9	Clinical	clinical	JJ
cord-306414-2dv3qced	282	10	characteristics	characteristic	NNS
cord-306414-2dv3qced	282	11	of	of	IN
cord-306414-2dv3qced	282	12	138	138	CD
cord-306414-2dv3qced	282	13	hospitalized	hospitalize	VBN
cord-306414-2dv3qced	282	14	patients	patient	NNS
cord-306414-2dv3qced	282	15	with	with	IN
cord-306414-2dv3qced	282	16	2019	2019	CD
cord-306414-2dv3qced	282	17	novel	novel	JJ
cord-306414-2dv3qced	282	18	coronavirus	coronavirus	NN
cord-306414-2dv3qced	282	19	-	-	HYPH
cord-306414-2dv3qced	282	20	infected	infect	VBN
cord-306414-2dv3qced	282	21	pneumonia	pneumonia	NN
cord-306414-2dv3qced	282	22	in	in	IN
cord-306414-2dv3qced	282	23	Wuhan	Wuhan	NNP
cord-306414-2dv3qced	282	24	,	,	,
cord-306414-2dv3qced	282	25	China	China	NNP
cord-306414-2dv3qced	282	26	Baseline	Baseline	NNP
cord-306414-2dv3qced	282	27	characteristics	characteristic	NNS
cord-306414-2dv3qced	282	28	and	and	CC
cord-306414-2dv3qced	282	29	outcomes	outcome	NNS
cord-306414-2dv3qced	282	30	of	of	IN
cord-306414-2dv3qced	282	31	1591	1591	CD
cord-306414-2dv3qced	282	32	patients	patient	NNS
cord-306414-2dv3qced	282	33	infected	infect	VBN
cord-306414-2dv3qced	282	34	with	with	IN
cord-306414-2dv3qced	282	35	SARS	SARS	NNP
cord-306414-2dv3qced	282	36	-	-	HYPH
cord-306414-2dv3qced	282	37	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	282	38	admitted	admit	VBD
cord-306414-2dv3qced	282	39	to	to	IN
cord-306414-2dv3qced	282	40	ICUs	ICUs	NNP
cord-306414-2dv3qced	282	41	of	of	IN
cord-306414-2dv3qced	282	42	the	the	DT
cord-306414-2dv3qced	282	43	Lombardy	Lombardy	NNP
cord-306414-2dv3qced	282	44	region	region	NN
cord-306414-2dv3qced	282	45	Characterization	characterization	NN
cord-306414-2dv3qced	282	46	of	of	IN
cord-306414-2dv3qced	282	47	the	the	DT
cord-306414-2dv3qced	282	48	receptor	receptor	NN
cord-306414-2dv3qced	282	49	-	-	HYPH
cord-306414-2dv3qced	282	50	binding	bind	VBG
cord-306414-2dv3qced	282	51	domain	domain	NN
cord-306414-2dv3qced	282	52	(	(	-LRB-
cord-306414-2dv3qced	282	53	RBD	RBD	NNP
cord-306414-2dv3qced	282	54	)	)	-RRB-
cord-306414-2dv3qced	282	55	of	of	IN
cord-306414-2dv3qced	282	56	2019	2019	CD
cord-306414-2dv3qced	282	57	novel	novel	JJ
cord-306414-2dv3qced	282	58	coronavirus	coronavirus	NN
cord-306414-2dv3qced	282	59	:	:	:
cord-306414-2dv3qced	282	60	implication	implication	NN
cord-306414-2dv3qced	282	61	for	for	IN
cord-306414-2dv3qced	282	62	development	development	NN
cord-306414-2dv3qced	282	63	of	of	IN
cord-306414-2dv3qced	282	64	RBD	RBD	NNP
cord-306414-2dv3qced	282	65	protein	protein	NN
cord-306414-2dv3qced	282	66	as	as	IN
cord-306414-2dv3qced	282	67	a	a	DT
cord-306414-2dv3qced	282	68	viral	viral	JJ
cord-306414-2dv3qced	282	69	attachment	attachment	NN
cord-306414-2dv3qced	282	70	inhibitor	inhibitor	NN
cord-306414-2dv3qced	282	71	and	and	CC
cord-306414-2dv3qced	282	72	vaccine	vaccine	NN
cord-306414-2dv3qced	283	1	The	the	DT
cord-306414-2dv3qced	283	2	pathogenicity	pathogenicity	NN
cord-306414-2dv3qced	283	3	of	of	IN
cord-306414-2dv3qced	283	4	SARS	SARS	NNP
cord-306414-2dv3qced	283	5	-	-	HYPH
cord-306414-2dv3qced	283	6	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	283	7	in	in	IN
cord-306414-2dv3qced	283	8	hACE2	hace2	NN
cord-306414-2dv3qced	283	9	transgenic	transgenic	JJ
cord-306414-2dv3qced	283	10	mice	mouse	NNS
cord-306414-2dv3qced	284	1	Pathological	pathological	JJ
cord-306414-2dv3qced	284	2	findings	finding	NNS
cord-306414-2dv3qced	284	3	of	of	IN
cord-306414-2dv3qced	284	4	COVID-19	COVID-19	NNP
cord-306414-2dv3qced	284	5	associated	associate	VBN
cord-306414-2dv3qced	284	6	with	with	IN
cord-306414-2dv3qced	284	7	acute	acute	JJ
cord-306414-2dv3qced	284	8	respiratory	respiratory	JJ
cord-306414-2dv3qced	284	9	distress	distress	NN
cord-306414-2dv3qced	284	10	syndrome	syndrome	NN
cord-306414-2dv3qced	285	1	The	the	DT
cord-306414-2dv3qced	285	2	laboratory	laboratory	NN
cord-306414-2dv3qced	285	3	tests	test	NNS
cord-306414-2dv3qced	285	4	and	and	CC
cord-306414-2dv3qced	285	5	host	host	NN
cord-306414-2dv3qced	285	6	immunity	immunity	NN
cord-306414-2dv3qced	285	7	of	of	IN
cord-306414-2dv3qced	285	8	COVID-19	covid-19	JJ
cord-306414-2dv3qced	285	9	patients	patient	NNS
cord-306414-2dv3qced	285	10	with	with	IN
cord-306414-2dv3qced	285	11	different	different	JJ
cord-306414-2dv3qced	285	12	severity	severity	NN
cord-306414-2dv3qced	285	13	of	of	IN
cord-306414-2dv3qced	285	14	illness	illness	NN
cord-306414-2dv3qced	285	15	Clinical	clinical	JJ
cord-306414-2dv3qced	285	16	and	and	CC
cord-306414-2dv3qced	285	17	immunological	immunological	JJ
cord-306414-2dv3qced	285	18	features	feature	NNS
cord-306414-2dv3qced	285	19	of	of	IN
cord-306414-2dv3qced	285	20	severe	severe	JJ
cord-306414-2dv3qced	285	21	and	and	CC
cord-306414-2dv3qced	285	22	moderate	moderate	JJ
cord-306414-2dv3qced	285	23	coronavirus	coronavirus	NN
cord-306414-2dv3qced	285	24	disease	disease	NN
cord-306414-2dv3qced	285	25	2019	2019	CD
cord-306414-2dv3qced	285	26	Prognostic	prognostic	JJ
cord-306414-2dv3qced	285	27	value	value	NN
cord-306414-2dv3qced	285	28	of	of	IN
cord-306414-2dv3qced	285	29	interleukin-6	interleukin-6	NNP
cord-306414-2dv3qced	285	30	,	,	,
cord-306414-2dv3qced	285	31	C	C	NNP
cord-306414-2dv3qced	285	32	-	-	HYPH
cord-306414-2dv3qced	285	33	reactive	reactive	JJ
cord-306414-2dv3qced	285	34	protein	protein	NN
cord-306414-2dv3qced	285	35	,	,	,
cord-306414-2dv3qced	285	36	and	and	CC
cord-306414-2dv3qced	285	37	procalcitonin	procalcitonin	NNS
cord-306414-2dv3qced	285	38	in	in	IN
cord-306414-2dv3qced	285	39	patients	patient	NNS
cord-306414-2dv3qced	285	40	with	with	IN
cord-306414-2dv3qced	285	41	COVID-19	COVID-19	NNP
cord-306414-2dv3qced	285	42	Dysregulation	Dysregulation	NNP
cord-306414-2dv3qced	285	43	of	of	IN
cord-306414-2dv3qced	285	44	immune	immune	JJ
cord-306414-2dv3qced	285	45	response	response	NN
cord-306414-2dv3qced	285	46	in	in	IN
cord-306414-2dv3qced	285	47	patients	patient	NNS
cord-306414-2dv3qced	285	48	with	with	IN
cord-306414-2dv3qced	285	49	COVID-19	COVID-19	NNP
cord-306414-2dv3qced	285	50	in	in	IN
cord-306414-2dv3qced	285	51	Wuhan	Wuhan	NNP
cord-306414-2dv3qced	285	52	Single	single	JJ
cord-306414-2dv3qced	285	53	-	-	HYPH
cord-306414-2dv3qced	285	54	cell	cell	NN
cord-306414-2dv3qced	285	55	landscape	landscape	NN
cord-306414-2dv3qced	285	56	of	of	IN
cord-306414-2dv3qced	285	57	bronchoalveolar	bronchoalveolar	JJ
cord-306414-2dv3qced	285	58	immune	immune	JJ
cord-306414-2dv3qced	285	59	cells	cell	NNS
cord-306414-2dv3qced	285	60	in	in	IN
cord-306414-2dv3qced	285	61	patients	patient	NNS
cord-306414-2dv3qced	285	62	with	with	IN
cord-306414-2dv3qced	285	63	COVID-19	COVID-19	NNP
cord-306414-2dv3qced	285	64	Treatment	Treatment	NNP
cord-306414-2dv3qced	285	65	of	of	IN
cord-306414-2dv3qced	285	66	5	5	CD
cord-306414-2dv3qced	285	67	critically	critically	RB
cord-306414-2dv3qced	285	68	ill	ill	JJ
cord-306414-2dv3qced	285	69	patients	patient	NNS
cord-306414-2dv3qced	285	70	with	with	IN
cord-306414-2dv3qced	285	71	COVID-19	COVID-19	NNP
cord-306414-2dv3qced	285	72	with	with	IN
cord-306414-2dv3qced	285	73	convalescent	convalescent	JJ
cord-306414-2dv3qced	285	74	plasma	plasma	NN
cord-306414-2dv3qced	285	75	Effectiveness	Effectiveness	NNP
cord-306414-2dv3qced	285	76	of	of	IN
cord-306414-2dv3qced	285	77	convalescent	convalescent	JJ
cord-306414-2dv3qced	285	78	plasma	plasma	NN
cord-306414-2dv3qced	285	79	therapy	therapy	NN
cord-306414-2dv3qced	285	80	in	in	IN
cord-306414-2dv3qced	285	81	severe	severe	JJ
cord-306414-2dv3qced	285	82	COVID-19	covid-19	CD
cord-306414-2dv3qced	285	83	patients	patient	NNS
cord-306414-2dv3qced	285	84	Antibody	Antibody	NNP
cord-306414-2dv3qced	285	85	responses	response	NNS
cord-306414-2dv3qced	285	86	to	to	IN
cord-306414-2dv3qced	285	87	SARS	SARS	NNP
cord-306414-2dv3qced	285	88	-	-	HYPH
cord-306414-2dv3qced	285	89	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	285	90	in	in	IN
cord-306414-2dv3qced	285	91	patients	patient	NNS
cord-306414-2dv3qced	285	92	with	with	IN
cord-306414-2dv3qced	285	93	COVID-19	COVID-19	NNP
cord-306414-2dv3qced	285	94	Antiviral	Antiviral	NNP
cord-306414-2dv3qced	285	95	CD8(+	CD8(+	NNP
cord-306414-2dv3qced	285	96	)	)	-RRB-
cord-306414-2dv3qced	286	1	T	t	NN
cord-306414-2dv3qced	286	2	cells	cell	NNS
cord-306414-2dv3qced	286	3	restricted	restrict	VBN
cord-306414-2dv3qced	286	4	by	by	IN
cord-306414-2dv3qced	286	5	human	human	JJ
cord-306414-2dv3qced	286	6	leukocyte	leukocyte	NN
cord-306414-2dv3qced	286	7	antigen	antigen	NN
cord-306414-2dv3qced	286	8	class	class	NN
cord-306414-2dv3qced	286	9	II	II	NNP
cord-306414-2dv3qced	286	10	exist	exist	VBP
cord-306414-2dv3qced	286	11	during	during	IN
cord-306414-2dv3qced	286	12	natural	natural	JJ
cord-306414-2dv3qced	286	13	HIV	HIV	NNP
cord-306414-2dv3qced	286	14	infection	infection	NN
cord-306414-2dv3qced	286	15	and	and	CC
cord-306414-2dv3qced	286	16	exhibit	exhibit	NN
cord-306414-2dv3qced	286	17	clonal	clonal	JJ
cord-306414-2dv3qced	286	18	expansion	expansion	NN
cord-306414-2dv3qced	286	19	Human	Human	NNP
cord-306414-2dv3qced	286	20	in	in	IN
cord-306414-2dv3qced	286	21	vivo	vivo	NN
cord-306414-2dv3qced	286	22	-	-	HYPH
cord-306414-2dv3qced	286	23	generated	generate	VBN
cord-306414-2dv3qced	286	24	monocyte	monocyte	NNP
cord-306414-2dv3qced	286	25	-	-	HYPH
cord-306414-2dv3qced	286	26	derived	derive	VBN
cord-306414-2dv3qced	286	27	dendritic	dendritic	JJ
cord-306414-2dv3qced	286	28	cells	cell	NNS
cord-306414-2dv3qced	286	29	and	and	CC
cord-306414-2dv3qced	286	30	macrophages	macrophage	NNS
cord-306414-2dv3qced	286	31	crosspresent	crosspresent	NN
cord-306414-2dv3qced	286	32	antigens	antigen	NNS
cord-306414-2dv3qced	286	33	through	through	IN
cord-306414-2dv3qced	286	34	a	a	DT
cord-306414-2dv3qced	286	35	vacuolar	vacuolar	JJ
cord-306414-2dv3qced	286	36	pathway	pathway	NN
cord-306414-2dv3qced	286	37	Select	Select	NNP
cord-306414-2dv3qced	286	38	sequencing	sequencing	NN
cord-306414-2dv3qced	286	39	of	of	IN
cord-306414-2dv3qced	287	1	clonally	clonally	NNP
cord-306414-2dv3qced	287	2	expanded	expand	VBD
cord-306414-2dv3qced	287	3	CD8(+	cd8(+	CD
cord-306414-2dv3qced	287	4	)	)	-RRB-
cord-306414-2dv3qced	288	1	T	T	NNP
cord-306414-2dv3qced	288	2	cells	cell	NNS
cord-306414-2dv3qced	288	3	reveals	reveal	VBZ
cord-306414-2dv3qced	288	4	limits	limit	NNS
cord-306414-2dv3qced	288	5	to	to	IN
cord-306414-2dv3qced	288	6	clonal	clonal	JJ
cord-306414-2dv3qced	288	7	expansion	expansion	NN
cord-306414-2dv3qced	288	8	Regulating	regulate	VBG
cord-306414-2dv3qced	288	9	the	the	DT
cord-306414-2dv3qced	288	10	adaptive	adaptive	JJ
cord-306414-2dv3qced	288	11	immune	immune	JJ
cord-306414-2dv3qced	288	12	response	response	NN
cord-306414-2dv3qced	288	13	to	to	IN
cord-306414-2dv3qced	288	14	respiratory	respiratory	JJ
cord-306414-2dv3qced	288	15	virus	virus	NN
cord-306414-2dv3qced	288	16	infection	infection	NN
cord-306414-2dv3qced	288	17	Broad	Broad	NNP
cord-306414-2dv3qced	288	18	TCR	TCR	NNP
cord-306414-2dv3qced	288	19	repertoire	repertoire	NN
cord-306414-2dv3qced	288	20	and	and	CC
cord-306414-2dv3qced	288	21	diverse	diverse	JJ
cord-306414-2dv3qced	288	22	structural	structural	JJ
cord-306414-2dv3qced	288	23	solutions	solution	NNS
cord-306414-2dv3qced	288	24	for	for	IN
cord-306414-2dv3qced	288	25	recognition	recognition	NN
cord-306414-2dv3qced	288	26	of	of	IN
cord-306414-2dv3qced	288	27	an	an	DT
cord-306414-2dv3qced	288	28	immunodominant	immunodominant	JJ
cord-306414-2dv3qced	288	29	CD8(+	CD8(+	NNP
cord-306414-2dv3qced	288	30	)	)	-RRB-
cord-306414-2dv3qced	288	31	T	t	NN
cord-306414-2dv3qced	288	32	cell	cell	NN
cord-306414-2dv3qced	288	33	epitope	epitope	NN
cord-306414-2dv3qced	288	34	MHC	MHC	NNP
cord-306414-2dv3qced	288	35	class	class	NN
cord-306414-2dv3qced	288	36	I	-PRON-	PRP
cord-306414-2dv3qced	288	37	antigen	antigen	NN
cord-306414-2dv3qced	288	38	presentation	presentation	NN
cord-306414-2dv3qced	288	39	:	:	:
cord-306414-2dv3qced	288	40	learning	learn	VBG
cord-306414-2dv3qced	288	41	from	from	IN
cord-306414-2dv3qced	288	42	viral	viral	JJ
cord-306414-2dv3qced	288	43	evasion	evasion	NN
cord-306414-2dv3qced	288	44	strategies	strategy	NNS
cord-306414-2dv3qced	288	45	HIV-1	HIV-1	NNP
cord-306414-2dv3qced	288	46	Nef	Nef	NNP
cord-306414-2dv3qced	288	47	impairs	impair	VBZ
cord-306414-2dv3qced	288	48	MHC	MHC	NNP
cord-306414-2dv3qced	288	49	class	class	NN
cord-306414-2dv3qced	288	50	II	II	NNP
cord-306414-2dv3qced	288	51	antigen	antigen	NN
cord-306414-2dv3qced	288	52	presentation	presentation	NN
cord-306414-2dv3qced	288	53	and	and	CC
cord-306414-2dv3qced	288	54	surface	surface	NN
cord-306414-2dv3qced	288	55	expression	expression	NN
cord-306414-2dv3qced	289	1	Quantifiable	quantifiable	JJ
cord-306414-2dv3qced	289	2	predictive	predictive	JJ
cord-306414-2dv3qced	289	3	features	feature	NNS
cord-306414-2dv3qced	289	4	define	define	VBP
cord-306414-2dv3qced	289	5	epitope	epitope	NN
cord-306414-2dv3qced	289	6	-	-	HYPH
cord-306414-2dv3qced	289	7	specific	specific	JJ
cord-306414-2dv3qced	289	8	T	t	NN
cord-306414-2dv3qced	289	9	cell	cell	NN
cord-306414-2dv3qced	289	10	receptor	receptor	NN
cord-306414-2dv3qced	289	11	repertoires	repertoire	NNS
cord-306414-2dv3qced	290	1	The	the	DT
cord-306414-2dv3qced	290	2	mechanism	mechanism	NN
cord-306414-2dv3qced	290	3	and	and	CC
cord-306414-2dv3qced	290	4	regulation	regulation	NN
cord-306414-2dv3qced	290	5	of	of	IN
cord-306414-2dv3qced	290	6	chromosomal	chromosomal	JJ
cord-306414-2dv3qced	290	7	V(D)J	V(D)J	NNP
cord-306414-2dv3qced	290	8	recombination	recombination	NN
cord-306414-2dv3qced	290	9	Lack	lack	NN
cord-306414-2dv3qced	290	10	of	of	IN
cord-306414-2dv3qced	290	11	N	n	CD
cord-306414-2dv3qced	290	12	regions	region	NNS
cord-306414-2dv3qced	290	13	in	in	IN
cord-306414-2dv3qced	290	14	antigen	antigen	NN
cord-306414-2dv3qced	290	15	receptor	receptor	NN
cord-306414-2dv3qced	290	16	variable	variable	JJ
cord-306414-2dv3qced	290	17	region	region	NN
cord-306414-2dv3qced	290	18	genes	gene	NNS
cord-306414-2dv3qced	290	19	of	of	IN
cord-306414-2dv3qced	290	20	TdT	tdt	NN
cord-306414-2dv3qced	290	21	-	-	HYPH
cord-306414-2dv3qced	290	22	deficient	deficient	JJ
cord-306414-2dv3qced	290	23	lymphocytes	lymphocyte	NNS
cord-306414-2dv3qced	290	24	The	the	DT
cord-306414-2dv3qced	290	25	many	many	JJ
cord-306414-2dv3qced	290	26	important	important	JJ
cord-306414-2dv3qced	290	27	facets	facet	NNS
cord-306414-2dv3qced	290	28	of	of	IN
cord-306414-2dv3qced	290	29	Tcell	Tcell	NNP
cord-306414-2dv3qced	290	30	repertoire	repertoire	NN
cord-306414-2dv3qced	290	31	diversity	diversity	NN
cord-306414-2dv3qced	290	32	Estimating	Estimating	NNP
cord-306414-2dv3qced	290	33	T	t	NN
cord-306414-2dv3qced	290	34	-	-	HYPH
cord-306414-2dv3qced	290	35	cell	cell	NN
cord-306414-2dv3qced	290	36	repertoire	repertoire	NN
cord-306414-2dv3qced	290	37	diversity	diversity	NN
cord-306414-2dv3qced	290	38	:	:	:
cord-306414-2dv3qced	290	39	limitations	limitation	NNS
cord-306414-2dv3qced	290	40	of	of	IN
cord-306414-2dv3qced	290	41	classical	classical	JJ
cord-306414-2dv3qced	290	42	estimators	estimator	NNS
cord-306414-2dv3qced	290	43	and	and	CC
cord-306414-2dv3qced	290	44	a	a	DT
cord-306414-2dv3qced	290	45	new	new	JJ
cord-306414-2dv3qced	290	46	approach	approach	NN
cord-306414-2dv3qced	290	47	Mapping	Mapping	NNP
cord-306414-2dv3qced	290	48	T	t	NN
cord-306414-2dv3qced	290	49	-	-	HYPH
cord-306414-2dv3qced	290	50	cell	cell	NN
cord-306414-2dv3qced	290	51	receptor	receptor	NN
cord-306414-2dv3qced	290	52	-	-	HYPH
cord-306414-2dv3qced	290	53	peptide	peptide	NN
cord-306414-2dv3qced	290	54	contacts	contact	NNS
cord-306414-2dv3qced	290	55	by	by	IN
cord-306414-2dv3qced	290	56	variant	variant	JJ
cord-306414-2dv3qced	290	57	peptide	peptide	NN
cord-306414-2dv3qced	290	58	immunization	immunization	NN
cord-306414-2dv3qced	290	59	of	of	IN
cord-306414-2dv3qced	290	60	single	single	JJ
cord-306414-2dv3qced	290	61	-	-	HYPH
cord-306414-2dv3qced	290	62	chain	chain	NN
cord-306414-2dv3qced	290	63	transgenics	transgenic	NNS
cord-306414-2dv3qced	290	64	Sequence	sequence	NN
cord-306414-2dv3qced	290	65	and	and	CC
cord-306414-2dv3qced	290	66	structural	structural	JJ
cord-306414-2dv3qced	290	67	analyses	analysis	NNS
cord-306414-2dv3qced	290	68	reveal	reveal	VBP
cord-306414-2dv3qced	290	69	distinct	distinct	JJ
cord-306414-2dv3qced	290	70	and	and	CC
cord-306414-2dv3qced	290	71	highly	highly	RB
cord-306414-2dv3qced	290	72	diverse	diverse	JJ
cord-306414-2dv3qced	290	73	human	human	JJ
cord-306414-2dv3qced	290	74	CD8(+	CD8(+	NNS
cord-306414-2dv3qced	290	75	)	)	-RRB-
cord-306414-2dv3qced	291	1	TCR	TCR	NNP
cord-306414-2dv3qced	291	2	repertoires	repertoire	NNS
cord-306414-2dv3qced	291	3	to	to	TO
cord-306414-2dv3qced	291	4	immunodominant	immunodominant	JJ
cord-306414-2dv3qced	291	5	viral	viral	JJ
cord-306414-2dv3qced	291	6	antigens	antigen	NNS
cord-306414-2dv3qced	291	7	Selection	Selection	NNP
cord-306414-2dv3qced	291	8	of	of	IN
cord-306414-2dv3qced	291	9	T	T	NNP
cord-306414-2dv3qced	291	10	cell	cell	NN
cord-306414-2dv3qced	291	11	clones	clone	NNS
cord-306414-2dv3qced	291	12	expressing	express	VBG
cord-306414-2dv3qced	291	13	high	high	JJ
cord-306414-2dv3qced	291	14	-	-	HYPH
cord-306414-2dv3qced	291	15	affinity	affinity	NN
cord-306414-2dv3qced	291	16	public	public	JJ
cord-306414-2dv3qced	291	17	TCRs	tcr	NNS
cord-306414-2dv3qced	291	18	within	within	IN
cord-306414-2dv3qced	291	19	human	human	JJ
cord-306414-2dv3qced	291	20	cytomegalovirus	cytomegalovirus	NN
cord-306414-2dv3qced	291	21	-	-	HYPH
cord-306414-2dv3qced	291	22	specific	specific	JJ
cord-306414-2dv3qced	291	23	CD8	CD8	NNP
cord-306414-2dv3qced	291	24	T	T	NNP
cord-306414-2dv3qced	291	25	cell	cell	NN
cord-306414-2dv3qced	291	26	responses	response	NNS
cord-306414-2dv3qced	291	27	Major	major	JJ
cord-306414-2dv3qced	291	28	expansion	expansion	NN
cord-306414-2dv3qced	291	29	of	of	IN
cord-306414-2dv3qced	291	30	CD8	CD8	NNP
cord-306414-2dv3qced	291	31	+	+	CC
cord-306414-2dv3qced	291	32	T	T	NNP
cord-306414-2dv3qced	291	33	cells	cell	NNS
cord-306414-2dv3qced	291	34	with	with	IN
cord-306414-2dv3qced	291	35	a	a	DT
cord-306414-2dv3qced	291	36	predominant	predominant	JJ
cord-306414-2dv3qced	291	37	V	v	NN
cord-306414-2dv3qced	291	38	beta	beta	NN
cord-306414-2dv3qced	291	39	usage	usage	NN
cord-306414-2dv3qced	291	40	during	during	IN
cord-306414-2dv3qced	291	41	the	the	DT
cord-306414-2dv3qced	291	42	primary	primary	JJ
cord-306414-2dv3qced	291	43	immune	immune	JJ
cord-306414-2dv3qced	291	44	response	response	NN
cord-306414-2dv3qced	291	45	to	to	IN
cord-306414-2dv3qced	291	46	HIV	HIV	NNP
cord-306414-2dv3qced	291	47	T	T	NNP
cord-306414-2dv3qced	291	48	cell	cell	NN
cord-306414-2dv3qced	291	49	selection	selection	NN
cord-306414-2dv3qced	291	50	during	during	IN
cord-306414-2dv3qced	291	51	the	the	DT
cord-306414-2dv3qced	291	52	evolution	evolution	NN
cord-306414-2dv3qced	291	53	of	of	IN
cord-306414-2dv3qced	291	54	CD8	CD8	NNP
cord-306414-2dv3qced	291	55	+	+	CC
cord-306414-2dv3qced	291	56	T	T	NNP
cord-306414-2dv3qced	291	57	cell	cell	NN
cord-306414-2dv3qced	291	58	memory	memory	NN
cord-306414-2dv3qced	291	59	in	in	IN
cord-306414-2dv3qced	291	60	vivo	vivo	NNP
cord-306414-2dv3qced	291	61	Single	single	JJ
cord-306414-2dv3qced	291	62	-	-	HYPH
cord-306414-2dv3qced	291	63	cell	cell	NN
cord-306414-2dv3qced	291	64	approach	approach	NN
cord-306414-2dv3qced	291	65	to	to	IN
cord-306414-2dv3qced	291	66	influenza	influenza	NN
cord-306414-2dv3qced	291	67	-	-	HYPH
cord-306414-2dv3qced	291	68	specific	specific	JJ
cord-306414-2dv3qced	291	69	CD8(+	CD8(+	NNS
cord-306414-2dv3qced	291	70	)	)	-RRB-
cord-306414-2dv3qced	291	71	T	t	NN
cord-306414-2dv3qced	291	72	cell	cell	NN
cord-306414-2dv3qced	291	73	receptor	receptor	NN
cord-306414-2dv3qced	291	74	repertoires	repertoire	NNS
cord-306414-2dv3qced	291	75	across	across	IN
cord-306414-2dv3qced	291	76	different	different	JJ
cord-306414-2dv3qced	291	77	age	age	NN
cord-306414-2dv3qced	291	78	groups	group	NNS
cord-306414-2dv3qced	291	79	,	,	,
cord-306414-2dv3qced	291	80	tissues	tissue	NNS
cord-306414-2dv3qced	291	81	,	,	,
cord-306414-2dv3qced	291	82	and	and	CC
cord-306414-2dv3qced	291	83	following	follow	VBG
cord-306414-2dv3qced	291	84	influenza	influenza	NN
cord-306414-2dv3qced	291	85	virus	virus	NN
cord-306414-2dv3qced	291	86	infection	infection	NN
cord-306414-2dv3qced	291	87	Epstein	Epstein	NNP
cord-306414-2dv3qced	291	88	-	-	HYPH
cord-306414-2dv3qced	291	89	Barr	Barr	NNP
cord-306414-2dv3qced	291	90	virus	virus	NN
cord-306414-2dv3qced	291	91	epitope	epitope	NN
cord-306414-2dv3qced	291	92	-	-	:
cord-306414-2dv3qced	291	93	major	major	JJ
cord-306414-2dv3qced	291	94	histocompatibility	histocompatibility	NN
cord-306414-2dv3qced	291	95	complex	complex	NN
cord-306414-2dv3qced	291	96	interaction	interaction	NN
cord-306414-2dv3qced	291	97	combined	combine	VBN
cord-306414-2dv3qced	291	98	with	with	IN
cord-306414-2dv3qced	291	99	convergent	convergent	JJ
cord-306414-2dv3qced	291	100	recombination	recombination	NN
cord-306414-2dv3qced	291	101	drives	drive	VBZ
cord-306414-2dv3qced	291	102	selection	selection	NN
cord-306414-2dv3qced	291	103	of	of	IN
cord-306414-2dv3qced	291	104	diverse	diverse	JJ
cord-306414-2dv3qced	291	105	T	t	NN
cord-306414-2dv3qced	291	106	cell	cell	NN
cord-306414-2dv3qced	291	107	receptor	receptor	NN
cord-306414-2dv3qced	291	108	alpha	alpha	NN
cord-306414-2dv3qced	291	109	and	and	CC
cord-306414-2dv3qced	291	110	beta	beta	NN
cord-306414-2dv3qced	291	111	repertoires	repertoire	NNS
cord-306414-2dv3qced	291	112	Reverse	reverse	VBP
cord-306414-2dv3qced	291	113	TCR	TCR	NNP
cord-306414-2dv3qced	292	1	repertoire	repertoire	JJ
cord-306414-2dv3qced	292	2	evolution	evolution	NN
cord-306414-2dv3qced	292	3	toward	toward	IN
cord-306414-2dv3qced	292	4	dominant	dominant	JJ
cord-306414-2dv3qced	292	5	low	low	JJ
cord-306414-2dv3qced	292	6	-	-	HYPH
cord-306414-2dv3qced	292	7	affinity	affinity	NN
cord-306414-2dv3qced	292	8	clones	clone	NNS
cord-306414-2dv3qced	292	9	during	during	IN
cord-306414-2dv3qced	292	10	chronic	chronic	JJ
cord-306414-2dv3qced	292	11	CMV	CMV	NNP
cord-306414-2dv3qced	292	12	infection	infection	NN
cord-306414-2dv3qced	292	13	Dynamics	dynamic	NNS
cord-306414-2dv3qced	292	14	of	of	IN
cord-306414-2dv3qced	292	15	individual	individual	JJ
cord-306414-2dv3qced	292	16	T	t	NN
cord-306414-2dv3qced	292	17	cell	cell	NN
cord-306414-2dv3qced	292	18	repertoires	repertoire	NNS
cord-306414-2dv3qced	292	19	:	:	:
cord-306414-2dv3qced	292	20	from	from	IN
cord-306414-2dv3qced	292	21	cord	cord	NN
cord-306414-2dv3qced	292	22	blood	blood	NN
cord-306414-2dv3qced	292	23	to	to	IN
cord-306414-2dv3qced	292	24	centenarians	centenarian	NNS
cord-306414-2dv3qced	292	25	Characteristics	characteristic	NNS
cord-306414-2dv3qced	292	26	of	of	IN
cord-306414-2dv3qced	292	27	and	and	CC
cord-306414-2dv3qced	292	28	important	important	JJ
cord-306414-2dv3qced	292	29	lessons	lesson	NNS
cord-306414-2dv3qced	292	30	from	from	IN
cord-306414-2dv3qced	292	31	the	the	DT
cord-306414-2dv3qced	292	32	coronavirus	coronavirus	NN
cord-306414-2dv3qced	292	33	disease	disease	NN
cord-306414-2dv3qced	292	34	2019	2019	CD
cord-306414-2dv3qced	292	35	(	(	-LRB-
cord-306414-2dv3qced	292	36	COVID-19	COVID-19	NNP
cord-306414-2dv3qced	292	37	)	)	-RRB-
cord-306414-2dv3qced	292	38	outbreak	outbreak	NN
cord-306414-2dv3qced	292	39	in	in	IN
cord-306414-2dv3qced	292	40	China	China	NNP
cord-306414-2dv3qced	292	41	:	:	:
cord-306414-2dv3qced	292	42	summary	summary	NN
cord-306414-2dv3qced	292	43	of	of	IN
cord-306414-2dv3qced	292	44	a	a	DT
cord-306414-2dv3qced	292	45	report	report	NN
cord-306414-2dv3qced	292	46	of	of	IN
cord-306414-2dv3qced	292	47	72314	72314	CD
cord-306414-2dv3qced	292	48	cases	case	NNS
cord-306414-2dv3qced	292	49	from	from	IN
cord-306414-2dv3qced	292	50	the	the	DT
cord-306414-2dv3qced	292	51	Chinese	Chinese	NNP
cord-306414-2dv3qced	292	52	Center	Center	NNP
cord-306414-2dv3qced	292	53	for	for	IN
cord-306414-2dv3qced	292	54	Disease	Disease	NNP
cord-306414-2dv3qced	292	55	Control	Control	NNP
cord-306414-2dv3qced	292	56	and	and	CC
cord-306414-2dv3qced	292	57	Prevention	Prevention	NNP
cord-306414-2dv3qced	293	1	Clinical	clinical	JJ
cord-306414-2dv3qced	293	2	course	course	NN
cord-306414-2dv3qced	293	3	and	and	CC
cord-306414-2dv3qced	293	4	risk	risk	NN
cord-306414-2dv3qced	293	5	factors	factor	NNS
cord-306414-2dv3qced	293	6	for	for	IN
cord-306414-2dv3qced	293	7	mortality	mortality	NN
cord-306414-2dv3qced	293	8	of	of	IN
cord-306414-2dv3qced	293	9	adult	adult	NN
cord-306414-2dv3qced	293	10	inpatients	inpatient	NNS
cord-306414-2dv3qced	293	11	with	with	IN
cord-306414-2dv3qced	293	12	COVID-19	COVID-19	NNP
cord-306414-2dv3qced	293	13	in	in	IN
cord-306414-2dv3qced	293	14	Wuhan	Wuhan	NNP
cord-306414-2dv3qced	293	15	,	,	,
cord-306414-2dv3qced	293	16	China	China	NNP
cord-306414-2dv3qced	293	17	:	:	:
cord-306414-2dv3qced	294	1	a	a	DT
cord-306414-2dv3qced	294	2	retrospective	retrospective	JJ
cord-306414-2dv3qced	294	3	cohort	cohort	NN
cord-306414-2dv3qced	294	4	study	study	NN
cord-306414-2dv3qced	294	5	Clinical	clinical	JJ
cord-306414-2dv3qced	294	6	predictors	predictor	NNS
cord-306414-2dv3qced	294	7	of	of	IN
cord-306414-2dv3qced	294	8	mortality	mortality	NN
cord-306414-2dv3qced	294	9	due	due	IN
cord-306414-2dv3qced	294	10	to	to	IN
cord-306414-2dv3qced	294	11	COVID-19	COVID-19	NNP
cord-306414-2dv3qced	294	12	based	base	VBN
cord-306414-2dv3qced	294	13	on	on	IN
cord-306414-2dv3qced	294	14	an	an	DT
cord-306414-2dv3qced	294	15	analysis	analysis	NN
cord-306414-2dv3qced	294	16	of	of	IN
cord-306414-2dv3qced	294	17	data	datum	NNS
cord-306414-2dv3qced	294	18	of	of	IN
cord-306414-2dv3qced	294	19	150	150	CD
cord-306414-2dv3qced	294	20	patients	patient	NNS
cord-306414-2dv3qced	294	21	from	from	IN
cord-306414-2dv3qced	294	22	Wuhan	Wuhan	NNP
cord-306414-2dv3qced	294	23	,	,	,
cord-306414-2dv3qced	294	24	China	China	NNP
cord-306414-2dv3qced	294	25	Perturbed	perturb	VBD
cord-306414-2dv3qced	294	26	CD8(+	CD8(+	NNP
cord-306414-2dv3qced	294	27	)	)	-RRB-
cord-306414-2dv3qced	295	1	T	t	NN
cord-306414-2dv3qced	295	2	cell	cell	NN
cord-306414-2dv3qced	295	3	immunity	immunity	NN
cord-306414-2dv3qced	295	4	across	across	IN
cord-306414-2dv3qced	295	5	universal	universal	JJ
cord-306414-2dv3qced	295	6	influenza	influenza	NN
cord-306414-2dv3qced	295	7	epitopes	epitope	NNS
cord-306414-2dv3qced	295	8	in	in	IN
cord-306414-2dv3qced	295	9	the	the	DT
cord-306414-2dv3qced	295	10	elderly	elderly	JJ
cord-306414-2dv3qced	295	11	Narrowing	narrowing	NN
cord-306414-2dv3qced	295	12	of	of	IN
cord-306414-2dv3qced	295	13	human	human	JJ
cord-306414-2dv3qced	295	14	influenza	influenza	NN
cord-306414-2dv3qced	295	15	A	a	DT
cord-306414-2dv3qced	295	16	virus	virus	NN
cord-306414-2dv3qced	295	17	-	-	HYPH
cord-306414-2dv3qced	295	18	specific	specific	JJ
cord-306414-2dv3qced	295	19	T	T	NNP
cord-306414-2dv3qced	295	20	cell	cell	NN
cord-306414-2dv3qced	295	21	receptor	receptor	NN
cord-306414-2dv3qced	295	22	alpha	alpha	NN
cord-306414-2dv3qced	295	23	and	and	CC
cord-306414-2dv3qced	295	24	beta	beta	NN
cord-306414-2dv3qced	295	25	repertoires	repertoire	NNS
cord-306414-2dv3qced	295	26	with	with	IN
cord-306414-2dv3qced	295	27	increasing	increase	VBG
cord-306414-2dv3qced	295	28	age	age	NN
cord-306414-2dv3qced	295	29	Genetic	genetic	JJ
cord-306414-2dv3qced	295	30	variation	variation	NN
cord-306414-2dv3qced	295	31	in	in	IN
cord-306414-2dv3qced	295	32	MHC	MHC	NNP
cord-306414-2dv3qced	295	33	proteins	protein	NNS
cord-306414-2dv3qced	295	34	is	be	VBZ
cord-306414-2dv3qced	295	35	associated	associate	VBN
cord-306414-2dv3qced	295	36	with	with	IN
cord-306414-2dv3qced	295	37	T	T	NNP
cord-306414-2dv3qced	295	38	cell	cell	NN
cord-306414-2dv3qced	295	39	receptor	receptor	NN
cord-306414-2dv3qced	295	40	expression	expression	NN
cord-306414-2dv3qced	295	41	biases	bias	NNS
cord-306414-2dv3qced	295	42	Influence	influence	NN
cord-306414-2dv3qced	295	43	of	of	IN
cord-306414-2dv3qced	295	44	HLA	HLA	NNP
cord-306414-2dv3qced	295	45	genes	gene	NNS
cord-306414-2dv3qced	295	46	on	on	IN
cord-306414-2dv3qced	295	47	T	T	NNP
cord-306414-2dv3qced	295	48	cell	cell	NN
cord-306414-2dv3qced	295	49	receptor	receptor	NN
cord-306414-2dv3qced	295	50	V	v	NN
cord-306414-2dv3qced	295	51	segment	segment	NN
cord-306414-2dv3qced	295	52	frequencies	frequency	NNS
cord-306414-2dv3qced	295	53	and	and	CC
cord-306414-2dv3qced	295	54	expression	expression	NN
cord-306414-2dv3qced	295	55	levels	level	NNS
cord-306414-2dv3qced	295	56	in	in	IN
cord-306414-2dv3qced	295	57	peripheral	peripheral	JJ
cord-306414-2dv3qced	295	58	blood	blood	NN
cord-306414-2dv3qced	295	59	lymphocytes	lymphocyte	NNS
cord-306414-2dv3qced	296	1	Influence	influence	NN
cord-306414-2dv3qced	296	2	of	of	IN
cord-306414-2dv3qced	296	3	HLA	HLA	NNP
cord-306414-2dv3qced	296	4	class	class	NN
cord-306414-2dv3qced	296	5	I	i	NN
cord-306414-2dv3qced	296	6	and	and	CC
cord-306414-2dv3qced	296	7	class	class	NN
cord-306414-2dv3qced	296	8	II	ii	CD
cord-306414-2dv3qced	296	9	antigens	antigen	NNS
cord-306414-2dv3qced	296	10	on	on	IN
cord-306414-2dv3qced	296	11	the	the	DT
cord-306414-2dv3qced	296	12	peripheral	peripheral	JJ
cord-306414-2dv3qced	296	13	T	t	NN
cord-306414-2dv3qced	296	14	-	-	HYPH
cord-306414-2dv3qced	296	15	cell	cell	NN
cord-306414-2dv3qced	296	16	receptor	receptor	NN
cord-306414-2dv3qced	296	17	repertoire	repertoire	NN
cord-306414-2dv3qced	296	18	Relationship	relationship	NN
cord-306414-2dv3qced	296	19	between	between	IN
cord-306414-2dv3qced	296	20	HLA	HLA	NNP
cord-306414-2dv3qced	296	21	tissue	tissue	NN
cord-306414-2dv3qced	296	22	type	type	NN
cord-306414-2dv3qced	296	23	,	,	,
cord-306414-2dv3qced	296	24	CMV	CMV	NNP
cord-306414-2dv3qced	296	25	infection	infection	NN
cord-306414-2dv3qced	296	26	,	,	,
cord-306414-2dv3qced	296	27	and	and	CC
cord-306414-2dv3qced	296	28	acute	acute	JJ
cord-306414-2dv3qced	296	29	graft	graft	NN
cord-306414-2dv3qced	296	30	-	-	HYPH
cord-306414-2dv3qced	296	31	vs	vs	IN
cord-306414-2dv3qced	296	32	-	-	HYPH
cord-306414-2dv3qced	296	33	host	host	NN
cord-306414-2dv3qced	296	34	disease	disease	NN
cord-306414-2dv3qced	296	35	after	after	IN
cord-306414-2dv3qced	296	36	allogeneic	allogeneic	JJ
cord-306414-2dv3qced	296	37	hematopoietic	hematopoietic	JJ
cord-306414-2dv3qced	296	38	stem	stem	NN
cord-306414-2dv3qced	296	39	cell	cell	NN
cord-306414-2dv3qced	296	40	transplantation	transplantation	NN
cord-306414-2dv3qced	296	41	:	:	:
cord-306414-2dv3qced	296	42	single	single	JJ
cord-306414-2dv3qced	296	43	-	-	HYPH
cord-306414-2dv3qced	296	44	center	center	NN
cord-306414-2dv3qced	296	45	experience	experience	NN
cord-306414-2dv3qced	297	1	Preexisting	preexist	VBG
cord-306414-2dv3qced	297	2	CD8	CD8	NNP
cord-306414-2dv3qced	297	3	+	+	CC
cord-306414-2dv3qced	297	4	T	t	NN
cord-306414-2dv3qced	297	5	-	-	HYPH
cord-306414-2dv3qced	297	6	cell	cell	NN
cord-306414-2dv3qced	297	7	immunity	immunity	NN
cord-306414-2dv3qced	297	8	to	to	IN
cord-306414-2dv3qced	297	9	the	the	DT
cord-306414-2dv3qced	297	10	H7N9	H7N9	NNP
cord-306414-2dv3qced	297	11	influenza	influenza	NN
cord-306414-2dv3qced	297	12	A	a	DT
cord-306414-2dv3qced	297	13	virus	virus	NN
cord-306414-2dv3qced	297	14	varies	vary	VBZ
cord-306414-2dv3qced	297	15	across	across	IN
cord-306414-2dv3qced	297	16	ethnicities	ethnicity	NNS
cord-306414-2dv3qced	298	1	An	an	DT
cord-306414-2dv3qced	298	2	increased	increase	VBN
cord-306414-2dv3qced	298	3	frequency	frequency	NN
cord-306414-2dv3qced	298	4	in	in	IN
cord-306414-2dv3qced	298	5	HLA	HLA	NNP
cord-306414-2dv3qced	298	6	class	class	NN
cord-306414-2dv3qced	299	1	I	-PRON-	PRP
cord-306414-2dv3qced	299	2	alleles	allele	NNS
cord-306414-2dv3qced	299	3	and	and	CC
cord-306414-2dv3qced	299	4	haplotypes	haplotype	NNS
cord-306414-2dv3qced	299	5	suggests	suggest	VBZ
cord-306414-2dv3qced	299	6	genetic	genetic	JJ
cord-306414-2dv3qced	299	7	susceptibility	susceptibility	NN
cord-306414-2dv3qced	299	8	to	to	TO
cord-306414-2dv3qced	299	9	influenza	influenza	VB
cord-306414-2dv3qced	299	10	A	a	DT
cord-306414-2dv3qced	299	11	(	(	-LRB-
cord-306414-2dv3qced	299	12	H1N1	H1N1	NNP
cord-306414-2dv3qced	299	13	)	)	-RRB-
cord-306414-2dv3qced	299	14	2009	2009	CD
cord-306414-2dv3qced	299	15	pandemic	pandemic	NN
cord-306414-2dv3qced	299	16	:	:	:
cord-306414-2dv3qced	299	17	a	a	DT
cord-306414-2dv3qced	299	18	case	case	NN
cord-306414-2dv3qced	299	19	-	-	HYPH
cord-306414-2dv3qced	299	20	control	control	NN
cord-306414-2dv3qced	299	21	study	study	NN
cord-306414-2dv3qced	299	22	HLA	HLA	NNP
cord-306414-2dv3qced	299	23	targeting	target	VBG
cord-306414-2dv3qced	299	24	efficiency	efficiency	NN
cord-306414-2dv3qced	299	25	correlates	correlate	VBZ
cord-306414-2dv3qced	299	26	with	with	IN
cord-306414-2dv3qced	299	27	human	human	JJ
cord-306414-2dv3qced	299	28	T	t	NN
cord-306414-2dv3qced	299	29	-	-	HYPH
cord-306414-2dv3qced	299	30	cell	cell	NN
cord-306414-2dv3qced	299	31	response	response	NN
cord-306414-2dv3qced	299	32	magnitude	magnitude	NN
cord-306414-2dv3qced	299	33	and	and	CC
cord-306414-2dv3qced	299	34	with	with	IN
cord-306414-2dv3qced	299	35	mortality	mortality	NN
cord-306414-2dv3qced	299	36	from	from	IN
cord-306414-2dv3qced	299	37	influenza	influenza	NN
cord-306414-2dv3qced	299	38	A	a	DT
cord-306414-2dv3qced	299	39	infection	infection	NN
cord-306414-2dv3qced	299	40	Human	human	JJ
cord-306414-2dv3qced	299	41	leukocyte	leukocyte	NN
cord-306414-2dv3qced	299	42	antigen	antigen	NN
cord-306414-2dv3qced	299	43	susceptibility	susceptibility	NN
cord-306414-2dv3qced	299	44	map	map	NN
cord-306414-2dv3qced	299	45	for	for	IN
cord-306414-2dv3qced	299	46	SARS	SARS	NNP
cord-306414-2dv3qced	299	47	-	-	HYPH
cord-306414-2dv3qced	299	48	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	299	49	Association	Association	NNP
cord-306414-2dv3qced	299	50	of	of	IN
cord-306414-2dv3qced	299	51	HLA	HLA	NNP
cord-306414-2dv3qced	299	52	class	class	NN
cord-306414-2dv3qced	299	53	I	-PRON-	PRP
cord-306414-2dv3qced	299	54	with	with	IN
cord-306414-2dv3qced	299	55	severe	severe	JJ
cord-306414-2dv3qced	299	56	acute	acute	JJ
cord-306414-2dv3qced	299	57	respiratory	respiratory	JJ
cord-306414-2dv3qced	299	58	syndrome	syndrome	NN
cord-306414-2dv3qced	299	59	coronavirus	coronavirus	NN
cord-306414-2dv3qced	299	60	infection	infection	NN
cord-306414-2dv3qced	300	1	Revealing	reveal	VBG
cord-306414-2dv3qced	300	2	factors	factor	NNS
cord-306414-2dv3qced	300	3	determining	determine	VBG
cord-306414-2dv3qced	300	4	immunodominant	immunodominant	JJ
cord-306414-2dv3qced	300	5	responses	response	NNS
cord-306414-2dv3qced	300	6	against	against	IN
cord-306414-2dv3qced	300	7	dominant	dominant	JJ
cord-306414-2dv3qced	300	8	epitopes	epitope	NNS
cord-306414-2dv3qced	300	9	Human	Human	NNP
cord-306414-2dv3qced	300	10	T	T	NNP
cord-306414-2dv3qced	300	11	cell	cell	NN
cord-306414-2dv3qced	300	12	development	development	NN
cord-306414-2dv3qced	300	13	,	,	,
cord-306414-2dv3qced	300	14	localization	localization	NN
cord-306414-2dv3qced	300	15	,	,	,
cord-306414-2dv3qced	300	16	and	and	CC
cord-306414-2dv3qced	300	17	function	function	VB
cord-306414-2dv3qced	300	18	throughout	throughout	IN
cord-306414-2dv3qced	300	19	life	life	NNP
cord-306414-2dv3qced	300	20	T	T	NNP
cord-306414-2dv3qced	300	21	cell	cell	NN
cord-306414-2dv3qced	300	22	receptor	receptor	NN
cord-306414-2dv3qced	300	23	cross	cross	NN
cord-306414-2dv3qced	300	24	-	-	NN
cord-306414-2dv3qced	300	25	reactivity	reactivity	NN
cord-306414-2dv3qced	300	26	expanded	expand	VBN
cord-306414-2dv3qced	300	27	by	by	IN
cord-306414-2dv3qced	300	28	dramatic	dramatic	JJ
cord-306414-2dv3qced	300	29	peptide	peptide	NN
cord-306414-2dv3qced	300	30	-	-	HYPH
cord-306414-2dv3qced	300	31	MHC	MHC	NNP
cord-306414-2dv3qced	300	32	adaptability	adaptability	NN
cord-306414-2dv3qced	300	33	Targets	target	NNS
cord-306414-2dv3qced	300	34	of	of	IN
cord-306414-2dv3qced	300	35	T	T	NNP
cord-306414-2dv3qced	300	36	cell	cell	NN
cord-306414-2dv3qced	300	37	responses	response	NNS
cord-306414-2dv3qced	300	38	to	to	IN
cord-306414-2dv3qced	300	39	SARS	SARS	NNP
cord-306414-2dv3qced	300	40	-	-	HYPH
cord-306414-2dv3qced	300	41	CoV-2	CoV-2	NNP
cord-306414-2dv3qced	300	42	coronavirus	coronavirus	NN
cord-306414-2dv3qced	300	43	in	in	IN
cord-306414-2dv3qced	300	44	humans	human	NNS
cord-306414-2dv3qced	300	45	with	with	IN
cord-306414-2dv3qced	300	46	COVID-19	COVID-19	NNP
cord-306414-2dv3qced	300	47	disease	disease	NN
cord-306414-2dv3qced	300	48	and	and	CC
cord-306414-2dv3qced	300	49	unexposed	unexposed	JJ
cord-306414-2dv3qced	300	50	individuals	individual	NNS
cord-306414-2dv3qced	301	1	Immune	immune	JJ
cord-306414-2dv3qced	301	2	cell	cell	NN
cord-306414-2dv3qced	301	3	profiling	profiling	NN
cord-306414-2dv3qced	301	4	of	of	IN
cord-306414-2dv3qced	301	5	COVID-19	covid-19	JJ
cord-306414-2dv3qced	301	6	patients	patient	NNS
cord-306414-2dv3qced	301	7	in	in	IN
cord-306414-2dv3qced	301	8	the	the	DT
cord-306414-2dv3qced	301	9	recovery	recovery	NN
cord-306414-2dv3qced	301	10	stage	stage	NN
cord-306414-2dv3qced	301	11	by	by	IN
cord-306414-2dv3qced	301	12	single	single	JJ
cord-306414-2dv3qced	301	13	-	-	HYPH
cord-306414-2dv3qced	301	14	cell	cell	NN
cord-306414-2dv3qced	301	15	sequencing	sequencing	NN
cord-306414-2dv3qced	302	1	Identifying	identify	VBG
cord-306414-2dv3qced	302	2	specificity	specificity	NN
cord-306414-2dv3qced	302	3	groups	group	NNS
cord-306414-2dv3qced	302	4	in	in	IN
cord-306414-2dv3qced	302	5	the	the	DT
cord-306414-2dv3qced	302	6	T	T	NNP
cord-306414-2dv3qced	302	7	cell	cell	NN
cord-306414-2dv3qced	302	8	receptor	receptor	NN
cord-306414-2dv3qced	302	9	repertoire	repertoire	NN
cord-306414-2dv3qced	303	1	The	the	DT
cord-306414-2dv3qced	303	2	membrane	membrane	NN
cord-306414-2dv3qced	303	3	protein	protein	NN
cord-306414-2dv3qced	303	4	of	of	IN
cord-306414-2dv3qced	303	5	severe	severe	JJ
cord-306414-2dv3qced	303	6	acute	acute	JJ
cord-306414-2dv3qced	303	7	respiratory	respiratory	JJ
cord-306414-2dv3qced	303	8	syndrome	syndrome	NN
cord-306414-2dv3qced	303	9	coronavirus	coronavirus	NN
cord-306414-2dv3qced	303	10	acts	act	VBZ
cord-306414-2dv3qced	303	11	as	as	IN
cord-306414-2dv3qced	303	12	a	a	DT
cord-306414-2dv3qced	303	13	dominant	dominant	JJ
cord-306414-2dv3qced	303	14	immunogen	immunogen	NN
cord-306414-2dv3qced	303	15	revealed	reveal	VBN
cord-306414-2dv3qced	303	16	by	by	IN
cord-306414-2dv3qced	303	17	a	a	DT
cord-306414-2dv3qced	303	18	clustering	clustering	NN
cord-306414-2dv3qced	303	19	region	region	NN
cord-306414-2dv3qced	303	20	of	of	IN
cord-306414-2dv3qced	303	21	novel	novel	NN
cord-306414-2dv3qced	303	22	functionally	functionally	RB
cord-306414-2dv3qced	303	23	and	and	CC
cord-306414-2dv3qced	303	24	structurally	structurally	RB
cord-306414-2dv3qced	303	25	defined	define	VBN
cord-306414-2dv3qced	303	26	cytotoxic	cytotoxic	JJ
cord-306414-2dv3qced	303	27	T	t	NN
cord-306414-2dv3qced	303	28	-	-	HYPH
cord-306414-2dv3qced	303	29	lymphocyte	lymphocyte	NN
cord-306414-2dv3qced	303	30	epitopes	epitope	NNS
cord-306414-2dv3qced	304	1	Immunosequencing	immunosequencing	NN
cord-306414-2dv3qced	304	2	identifies	identify	VBZ
cord-306414-2dv3qced	304	3	signatures	signature	NNS
cord-306414-2dv3qced	304	4	of	of	IN
cord-306414-2dv3qced	304	5	cytomegalovirus	cytomegalovirus	NN
cord-306414-2dv3qced	304	6	exposure	exposure	NN
cord-306414-2dv3qced	304	7	history	history	NN
cord-306414-2dv3qced	304	8	and	and	CC
cord-306414-2dv3qced	304	9	HLA	HLA	NNP
cord-306414-2dv3qced	304	10	-	-	HYPH
cord-306414-2dv3qced	304	11	mediated	mediate	VBN
cord-306414-2dv3qced	304	12	effects	effect	NNS
cord-306414-2dv3qced	304	13	on	on	IN
cord-306414-2dv3qced	304	14	the	the	DT
cord-306414-2dv3qced	304	15	T	T	NNP
cord-306414-2dv3qced	304	16	cell	cell	NN
cord-306414-2dv3qced	304	17	repertoire	repertoire	NN
cord-306414-2dv3qced	304	18	Precise	precise	JJ
cord-306414-2dv3qced	304	19	tracking	tracking	NN
cord-306414-2dv3qced	304	20	of	of	IN
cord-306414-2dv3qced	304	21	vaccineresponding	vaccineresponde	VBG
cord-306414-2dv3qced	304	22	T	t	NN
cord-306414-2dv3qced	304	23	cell	cell	NN
cord-306414-2dv3qced	304	24	clones	clone	NNS
cord-306414-2dv3qced	304	25	reveals	reveal	VBZ
cord-306414-2dv3qced	304	26	convergent	convergent	JJ
cord-306414-2dv3qced	304	27	and	and	CC
cord-306414-2dv3qced	304	28	personalized	personalized	JJ
cord-306414-2dv3qced	304	29	response	response	NN
cord-306414-2dv3qced	304	30	in	in	IN
cord-306414-2dv3qced	304	31	identical	identical	JJ
cord-306414-2dv3qced	304	32	twins	twin	NNS
cord-306414-2dv3qced	304	33	Identifying	identify	VBG
cord-306414-2dv3qced	304	34	and	and	CC
cord-306414-2dv3qced	304	35	tracking	track	VBG
cord-306414-2dv3qced	304	36	low	low	JJ
cord-306414-2dv3qced	304	37	-	-	HYPH
cord-306414-2dv3qced	304	38	frequency	frequency	NN
cord-306414-2dv3qced	304	39	virus	virus	NN
cord-306414-2dv3qced	304	40	-	-	HYPH
cord-306414-2dv3qced	304	41	specific	specific	JJ
cord-306414-2dv3qced	304	42	TCR	TCR	NNP
cord-306414-2dv3qced	304	43	clonotypes	clonotype	NNS
cord-306414-2dv3qced	304	44	using	use	VBG
cord-306414-2dv3qced	304	45	high	high	JJ
cord-306414-2dv3qced	304	46	-	-	HYPH
cord-306414-2dv3qced	304	47	throughput	throughput	NN
cord-306414-2dv3qced	304	48	sequencing	sequence	VBG
cord-306414-2dv3qced	304	49	CDR3	CDR3	NNP
cord-306414-2dv3qced	304	50	motif	motif	NN
cord-306414-2dv3qced	304	51	generation	generation	NN
cord-306414-2dv3qced	304	52	and	and	CC
cord-306414-2dv3qced	304	53	selection	selection	NN
cord-306414-2dv3qced	304	54	in	in	IN
cord-306414-2dv3qced	304	55	the	the	DT
cord-306414-2dv3qced	304	56	BV19-utilizing	bv19-utilize	VBG
cord-306414-2dv3qced	304	57	subset	subset	NN
cord-306414-2dv3qced	304	58	of	of	IN
cord-306414-2dv3qced	304	59	the	the	DT
cord-306414-2dv3qced	304	60	human	human	JJ
cord-306414-2dv3qced	304	61	CD8	CD8	NNP
cord-306414-2dv3qced	304	62	T	T	NNP
cord-306414-2dv3qced	304	63	cell	cell	NN
cord-306414-2dv3qced	304	64	repertoire	repertoire	NN
cord-306414-2dv3qced	304	65	Lymphocytes	lymphocyte	VBZ
cord-306414-2dv3qced	304	66	transiently	transiently	RB
cord-306414-2dv3qced	304	67	expressing	express	VBG
cord-306414-2dv3qced	304	68	virusspecific	virusspecific	NNP
cord-306414-2dv3qced	304	69	T	T	NNP
cord-306414-2dv3qced	304	70	cell	cell	NN
cord-306414-2dv3qced	304	71	receptors	receptor	NNS
cord-306414-2dv3qced	304	72	reduce	reduce	VBP
cord-306414-2dv3qced	304	73	hepatitis	hepatitis	NN
cord-306414-2dv3qced	304	74	B	b	NN
cord-306414-2dv3qced	304	75	virus	virus	NN
cord-306414-2dv3qced	304	76	infection	infection	NN
cord-306414-2dv3qced	304	77	Hepatitis	Hepatitis	NNP
cord-306414-2dv3qced	304	78	C	C	NNP
cord-306414-2dv3qced	304	79	virus	virus	NN
cord-306414-2dv3qced	304	80	-	-	HYPH
cord-306414-2dv3qced	304	81	specific	specific	JJ
cord-306414-2dv3qced	304	82	T	T	NNP
cord-306414-2dv3qced	304	83	cell	cell	NN
cord-306414-2dv3qced	304	84	receptor	receptor	NN
cord-306414-2dv3qced	304	85	mRNA	mrna	NN
cord-306414-2dv3qced	304	86	-	-	HYPH
cord-306414-2dv3qced	304	87	engineered	engineer	VBN
cord-306414-2dv3qced	304	88	human	human	NN
cord-306414-2dv3qced	304	89	T	t	NN
cord-306414-2dv3qced	304	90	cells	cell	NNS
cord-306414-2dv3qced	304	91	:	:	:
cord-306414-2dv3qced	304	92	impact	impact	NN
cord-306414-2dv3qced	304	93	of	of	IN
cord-306414-2dv3qced	304	94	antigen	antigen	NN
cord-306414-2dv3qced	304	95	specificity	specificity	NN
cord-306414-2dv3qced	304	96	on	on	IN
cord-306414-2dv3qced	304	97	functional	functional	JJ
cord-306414-2dv3qced	304	98	properties	property	NNS
cord-306414-2dv3qced	305	1	Engineering	Engineering	NNP
cord-306414-2dv3qced	305	2	T	t	CD
cord-306414-2dv3qced	305	3	cells	cell	NNS
cord-306414-2dv3qced	305	4	specific	specific	JJ
cord-306414-2dv3qced	305	5	for	for	IN
cord-306414-2dv3qced	305	6	a	a	DT
cord-306414-2dv3qced	305	7	dominant	dominant	JJ
cord-306414-2dv3qced	305	8	severe	severe	JJ
cord-306414-2dv3qced	305	9	acute	acute	JJ
cord-306414-2dv3qced	305	10	respiratory	respiratory	JJ
cord-306414-2dv3qced	305	11	syndrome	syndrome	NN
cord-306414-2dv3qced	305	12	coronavirus	coronavirus	NN
cord-306414-2dv3qced	306	1	CD8	CD8	NNP
cord-306414-2dv3qced	306	2	T	T	NNP
cord-306414-2dv3qced	306	3	cell	cell	NN
cord-306414-2dv3qced	306	4	epitope	epitope	NN
cord-306414-2dv3qced	306	5	T	T	NNP
cord-306414-2dv3qced	306	6	cell	cell	NN
cord-306414-2dv3qced	306	7	receptor	receptor	NN
cord-306414-2dv3qced	306	8	recognition	recognition	NN
cord-306414-2dv3qced	306	9	motifs	motif	NNS
cord-306414-2dv3qced	306	10	govern	govern	VBP
cord-306414-2dv3qced	306	11	immune	immune	JJ
cord-306414-2dv3qced	306	12	escape	escape	NN
cord-306414-2dv3qced	306	13	patterns	pattern	NNS
cord-306414-2dv3qced	306	14	in	in	IN
cord-306414-2dv3qced	306	15	acute	acute	JJ
cord-306414-2dv3qced	306	16	SIV	SIV	NNP
cord-306414-2dv3qced	306	17	infection	infection	NN
cord-306414-2dv3qced	307	1	Large	large	JJ
cord-306414-2dv3qced	307	2	TCR	TCR	NNP
cord-306414-2dv3qced	307	3	diversity	diversity	NN
cord-306414-2dv3qced	307	4	of	of	IN
cord-306414-2dv3qced	307	5	virus	virus	NN
cord-306414-2dv3qced	307	6	-	-	HYPH
cord-306414-2dv3qced	307	7	specific	specific	JJ
cord-306414-2dv3qced	307	8	CD8	CD8	NNP
cord-306414-2dv3qced	307	9	T	T	NNP
cord-306414-2dv3qced	307	10	cells	cell	NNS
cord-306414-2dv3qced	307	11	provides	provide	VBZ
cord-306414-2dv3qced	307	12	the	the	DT
cord-306414-2dv3qced	307	13	mechanistic	mechanistic	JJ
cord-306414-2dv3qced	307	14	basis	basis	NN
cord-306414-2dv3qced	307	15	for	for	IN
cord-306414-2dv3qced	307	16	massive	massive	JJ
cord-306414-2dv3qced	307	17	TCR	TCR	NNP
cord-306414-2dv3qced	307	18	renewal	renewal	NN
cord-306414-2dv3qced	307	19	after	after	IN
cord-306414-2dv3qced	307	20	antigen	antigen	NN
cord-306414-2dv3qced	307	21	exposure	exposure	NN
cord-306414-2dv3qced	307	22	Complete	Complete	NNP
cord-306414-2dv3qced	307	23	but	but	CC
cord-306414-2dv3qced	307	24	curtailed	curtail	VBD
cord-306414-2dv3qced	307	25	T	t	NN
cord-306414-2dv3qced	307	26	-	-	HYPH
cord-306414-2dv3qced	307	27	cell	cell	NN
cord-306414-2dv3qced	307	28	response	response	NN
cord-306414-2dv3qced	307	29	to	to	IN
cord-306414-2dv3qced	307	30	very	very	RB
cord-306414-2dv3qced	307	31	low	low	JJ
cord-306414-2dv3qced	307	32	-	-	HYPH
cord-306414-2dv3qced	307	33	affinity	affinity	NN
cord-306414-2dv3qced	307	34	antigen	antigen	NN
cord-306414-2dv3qced	307	35	Avidity	avidity	NN
cord-306414-2dv3qced	307	36	for	for	IN
cord-306414-2dv3qced	307	37	antigen	antigen	NN
cord-306414-2dv3qced	307	38	shapes	shape	NNS
cord-306414-2dv3qced	307	39	clonal	clonal	JJ
cord-306414-2dv3qced	307	40	dominance	dominance	NN
cord-306414-2dv3qced	307	41	in	in	IN
cord-306414-2dv3qced	307	42	CD8	CD8	NNP
cord-306414-2dv3qced	307	43	+	+	CC
cord-306414-2dv3qced	307	44	T	T	NNP
cord-306414-2dv3qced	307	45	cell	cell	NN
cord-306414-2dv3qced	307	46	populations	population	NNS
cord-306414-2dv3qced	307	47	specific	specific	JJ
cord-306414-2dv3qced	307	48	for	for	IN
cord-306414-2dv3qced	307	49	persistent	persistent	JJ
cord-306414-2dv3qced	307	50	DNA	dna	NN
cord-306414-2dv3qced	307	51	viruses	virus	NNS
cord-306414-2dv3qced	307	52	Design	Design	NNP
cord-306414-2dv3qced	307	53	of	of	IN
cord-306414-2dv3qced	307	54	a	a	DT
cord-306414-2dv3qced	307	55	multi	multi	JJ
cord-306414-2dv3qced	307	56	-	-	JJ
cord-306414-2dv3qced	307	57	center	center	JJ
cord-306414-2dv3qced	307	58	immunophenotyping	immunophenotyping	NN
cord-306414-2dv3qced	307	59	analysis	analysis	NN
cord-306414-2dv3qced	307	60	of	of	IN
cord-306414-2dv3qced	307	61	peripheral	peripheral	JJ
cord-306414-2dv3qced	307	62	blood	blood	NN
cord-306414-2dv3qced	307	63	,	,	,
cord-306414-2dv3qced	307	64	sputum	sputum	NN
cord-306414-2dv3qced	307	65	and	and	CC
cord-306414-2dv3qced	307	66	bronchoalveolar	bronchoalveolar	JJ
cord-306414-2dv3qced	307	67	lavage	lavage	NN
cord-306414-2dv3qced	307	68	fluid	fluid	NN
cord-306414-2dv3qced	307	69	in	in	IN
cord-306414-2dv3qced	307	70	the	the	DT
cord-306414-2dv3qced	307	71	Subpopulations	Subpopulations	NNPS
cord-306414-2dv3qced	307	72	and	and	CC
cord-306414-2dv3qced	307	73	Intermediate	Intermediate	NNP
cord-306414-2dv3qced	307	74	Outcome	Outcome	NNP
cord-306414-2dv3qced	307	75	Measures	measure	NNS
cord-306414-2dv3qced	307	76	in	in	IN
cord-306414-2dv3qced	307	77	COPD	COPD	NNP
cord-306414-2dv3qced	307	78	Study	Study	NNP
cord-306414-2dv3qced	307	79	(	(	-LRB-
cord-306414-2dv3qced	307	80	SPIROMICS	SPIROMICS	NNP
cord-306414-2dv3qced	307	81	)	)	-RRB-
cord-306414-2dv3qced	308	1	Practical	practical	JJ
cord-306414-2dv3qced	308	2	guidance	guidance	NN
cord-306414-2dv3qced	308	3	for	for	IN
cord-306414-2dv3qced	308	4	clinical	clinical	JJ
cord-306414-2dv3qced	308	5	microbiology	microbiology	NN
cord-306414-2dv3qced	308	6	laboratories	laboratory	NNS
cord-306414-2dv3qced	308	7	:	:	:
cord-306414-2dv3qced	308	8	viruses	virus	NNS
cord-306414-2dv3qced	308	9	causing	cause	VBG
cord-306414-2dv3qced	308	10	acute	acute	JJ
cord-306414-2dv3qced	308	11	respiratory	respiratory	JJ
cord-306414-2dv3qced	308	12	tract	tract	NN
cord-306414-2dv3qced	308	13	infections	infection	NNS
cord-306414-2dv3qced	308	14	Overview	Overview	NNP
cord-306414-2dv3qced	308	15	of	of	IN
cord-306414-2dv3qced	308	16	methodologies	methodology	NNS
cord-306414-2dv3qced	308	17	for	for	IN
cord-306414-2dv3qced	308	18	T	t	NN
cord-306414-2dv3qced	308	19	-	-	HYPH
cord-306414-2dv3qced	308	20	cell	cell	NN
cord-306414-2dv3qced	308	21	receptor	receptor	NN
cord-306414-2dv3qced	308	22	repertoire	repertoire	NN
cord-306414-2dv3qced	308	23	analysis	analysis	NN
cord-306414-2dv3qced	308	24	Evaluation	Evaluation	NNP
cord-306414-2dv3qced	308	25	of	of	IN
cord-306414-2dv3qced	308	26	bias	bias	NN
cord-306414-2dv3qced	308	27	associated	associate	VBN
cord-306414-2dv3qced	308	28	with	with	IN
cord-306414-2dv3qced	308	29	highmultiplex	highmultiplex	NN
cord-306414-2dv3qced	308	30	,	,	,
cord-306414-2dv3qced	308	31	target	target	NN
cord-306414-2dv3qced	308	32	-	-	HYPH
cord-306414-2dv3qced	308	33	specific	specific	JJ
cord-306414-2dv3qced	308	34	pre	pre	JJ
cord-306414-2dv3qced	308	35	-	-	JJ
cord-306414-2dv3qced	308	36	amplification	amplification	JJ
cord-306414-2dv3qced	308	37	High	high	JJ
cord-306414-2dv3qced	308	38	-	-	HYPH
cord-306414-2dv3qced	308	39	throughput	throughput	NN
cord-306414-2dv3qced	308	40	identification	identification	NN
cord-306414-2dv3qced	308	41	of	of	IN
cord-306414-2dv3qced	308	42	antigenspecific	antigenspecific	NNP
cord-306414-2dv3qced	308	43	TCRs	tcr	NNS
cord-306414-2dv3qced	308	44	by	by	IN
cord-306414-2dv3qced	308	45	TCR	TCR	NNP
cord-306414-2dv3qced	308	46	gene	gene	NN
cord-306414-2dv3qced	308	47	capture	capture	NN
cord-306414-2dv3qced	308	48	Preparing	prepare	VBG
cord-306414-2dv3qced	308	49	unbiased	unbiased	JJ
cord-306414-2dv3qced	308	50	T	t	NN
cord-306414-2dv3qced	308	51	-	-	HYPH
cord-306414-2dv3qced	308	52	cell	cell	NN
cord-306414-2dv3qced	308	53	receptor	receptor	NN
cord-306414-2dv3qced	308	54	and	and	CC
cord-306414-2dv3qced	308	55	antibody	antibody	NN
cord-306414-2dv3qced	308	56	cDNA	cdna	NN
cord-306414-2dv3qced	308	57	libraries	library	NNS
cord-306414-2dv3qced	308	58	for	for	IN
cord-306414-2dv3qced	308	59	the	the	DT
cord-306414-2dv3qced	308	60	deep	deep	JJ
cord-306414-2dv3qced	308	61	next	next	JJ
cord-306414-2dv3qced	308	62	generation	generation	NN
cord-306414-2dv3qced	308	63	sequencing	sequencing	NN
cord-306414-2dv3qced	308	64	profiling	profile	VBG
cord-306414-2dv3qced	308	65	Rapid	rapid	JJ
cord-306414-2dv3qced	308	66	amplification	amplification	NN
cord-306414-2dv3qced	308	67	of	of	IN
cord-306414-2dv3qced	308	68	5′	5′	CD
cord-306414-2dv3qced	308	69	complementary	complementary	JJ
cord-306414-2dv3qced	308	70	DNA	dna	NN
cord-306414-2dv3qced	308	71	ends	end	NNS
cord-306414-2dv3qced	308	72	(	(	-LRB-
cord-306414-2dv3qced	308	73	5′	5′	CD
cord-306414-2dv3qced	308	74	RACE	race	NN
cord-306414-2dv3qced	308	75	)	)	-RRB-
cord-306414-2dv3qced	309	1	Sequence	sequence	NN
cord-306414-2dv3qced	309	2	analysis	analysis	NN
cord-306414-2dv3qced	309	3	of	of	IN
cord-306414-2dv3qced	309	4	T	t	NN
cord-306414-2dv3qced	309	5	-	-	HYPH
cord-306414-2dv3qced	309	6	cell	cell	NN
cord-306414-2dv3qced	309	7	repertoires	repertoire	NNS
cord-306414-2dv3qced	309	8	in	in	IN
cord-306414-2dv3qced	309	9	health	health	NN
cord-306414-2dv3qced	309	10	and	and	CC
cord-306414-2dv3qced	309	11	disease	disease	NN
cord-306414-2dv3qced	309	12	MiXCR	MiXCR	NNP
cord-306414-2dv3qced	309	13	:	:	:
cord-306414-2dv3qced	309	14	software	software	NN
cord-306414-2dv3qced	309	15	for	for	IN
cord-306414-2dv3qced	309	16	comprehensive	comprehensive	JJ
cord-306414-2dv3qced	309	17	adaptive	adaptive	JJ
cord-306414-2dv3qced	309	18	immunity	immunity	NN
cord-306414-2dv3qced	309	19	profiling	profiling	NN
cord-306414-2dv3qced	310	1	VDJtools	vdjtool	NNS
cord-306414-2dv3qced	310	2	:	:	:
cord-306414-2dv3qced	311	1	unifying	unify	VBG
cord-306414-2dv3qced	311	2	post	post	NN
cord-306414-2dv3qced	311	3	-	-	NN
cord-306414-2dv3qced	311	4	analysis	analysis	NN
cord-306414-2dv3qced	311	5	of	of	IN
cord-306414-2dv3qced	311	6	T	T	NNP
cord-306414-2dv3qced	311	7	cell	cell	NN
cord-306414-2dv3qced	311	8	receptor	receptor	NN
cord-306414-2dv3qced	311	9	repertoires	repertoire	NNS
cord-306414-2dv3qced	312	1	Longitudinal	longitudinal	JJ
cord-306414-2dv3qced	312	2	high	high	JJ
cord-306414-2dv3qced	312	3	-	-	HYPH
cord-306414-2dv3qced	312	4	throughput	throughput	NN
cord-306414-2dv3qced	312	5	TCR	TCR	NNP
cord-306414-2dv3qced	312	6	repertoire	repertoire	NN
cord-306414-2dv3qced	312	7	profiling	profiling	NN
cord-306414-2dv3qced	312	8	reveals	reveal	VBZ
cord-306414-2dv3qced	312	9	the	the	DT
cord-306414-2dv3qced	312	10	dynamics	dynamic	NNS
cord-306414-2dv3qced	312	11	of	of	IN
cord-306414-2dv3qced	312	12	T	T	NNP
cord-306414-2dv3qced	312	13	cell	cell	NN
cord-306414-2dv3qced	312	14	memory	memory	NN
cord-306414-2dv3qced	312	15	formation	formation	NN
cord-306414-2dv3qced	312	16	after	after	IN
cord-306414-2dv3qced	312	17	mild	mild	JJ
cord-306414-2dv3qced	312	18	COVID-19	covid-19	CD
cord-306414-2dv3qced	312	19	infection	infection	NN
cord-306414-2dv3qced	313	1	We	-PRON-	PRP
cord-306414-2dv3qced	313	2	acknowledge	acknowledge	VBP
cord-306414-2dv3qced	313	3	the	the	DT
cord-306414-2dv3qced	313	4	University	University	NNP
cord-306414-2dv3qced	313	5	of	of	IN
cord-306414-2dv3qced	313	6	Southern	Southern	NNP
cord-306414-2dv3qced	313	7	California	California	NNP
cord-306414-2dv3qced	313	8	,	,	,
cord-306414-2dv3qced	313	9	School	School	NNP
cord-306414-2dv3qced	313	10	of	of	IN
cord-306414-2dv3qced	313	11	Pharmacy	Pharmacy	NNP
cord-306414-2dv3qced	313	12	Seed	Seed	NNP
cord-306414-2dv3qced	313	13	Fund	Fund	NNP
cord-306414-2dv3qced	313	14	,	,	,
cord-306414-2dv3qced	313	15	and	and	CC
cord-306414-2dv3qced	313	16	The	the	DT
cord-306414-2dv3qced	313	17	Norris	Norris	NNP
cord-306414-2dv3qced	313	18	Cancer	Cancer	NNP
cord-306414-2dv3qced	313	19	Center	Center	NNP
cord-306414-2dv3qced	313	20	pilot	pilot	NN
cord-306414-2dv3qced	313	21	funding	funding	NN
cord-306414-2dv3qced	313	22	that	that	WDT
cord-306414-2dv3qced	313	23	support	support	VBP
cord-306414-2dv3qced	313	24	HA	HA	NNP
cord-306414-2dv3qced	313	25	research	research	NN
cord-306414-2dv3qced	313	26	effort	effort	NN
cord-306414-2dv3qced	313	27	.	.	.
cord-306414-2dv3qced	314	1	All	all	DT
cord-306414-2dv3qced	314	2	figures	figure	NNS
cord-306414-2dv3qced	314	3	were	be	VBD
cord-306414-2dv3qced	314	4	made	make	VBN
cord-306414-2dv3qced	314	5	with	with	IN
cord-306414-2dv3qced	314	6	BioRender	BioRender	NNP
cord-306414-2dv3qced	314	7	(	(	-LRB-
cord-306414-2dv3qced	314	8	https://biorender.com/	https://biorender.com/	NN
cord-306414-2dv3qced	314	9	)	)	-RRB-
cord-306414-2dv3qced	314	10	.	.	.
cord-306414-2dv3qced	314	11	 	 	_SP