id sid tid token lemma pos cord-305956-l02xdq87 1 1 key key JJ cord-305956-l02xdq87 2 1 : : : cord-305956-l02xdq87 2 2 cord-305956-l02xdq87 cord-305956-l02xdq87 CD cord-305956-l02xdq87 2 3 authors author NNS cord-305956-l02xdq87 2 4 : : : cord-305956-l02xdq87 2 5 Alqahtani Alqahtani NNP cord-305956-l02xdq87 2 6 , , , cord-305956-l02xdq87 2 7 Saleh Saleh NNP cord-305956-l02xdq87 2 8 A A NNP cord-305956-l02xdq87 2 9 ; ; : cord-305956-l02xdq87 2 10 Schattenberg Schattenberg NNP cord-305956-l02xdq87 2 11 , , , cord-305956-l02xdq87 2 12 Jörn Jörn NNP cord-305956-l02xdq87 2 13 M M NNP cord-305956-l02xdq87 2 14 title title NN cord-305956-l02xdq87 2 15 : : : cord-305956-l02xdq87 2 16 Liver liver NN cord-305956-l02xdq87 2 17 injury injury NN cord-305956-l02xdq87 2 18 in in IN cord-305956-l02xdq87 2 19 COVID-19 COVID-19 NNP cord-305956-l02xdq87 2 20 : : : cord-305956-l02xdq87 2 21 The the DT cord-305956-l02xdq87 2 22 current current JJ cord-305956-l02xdq87 2 23 evidence evidence NN cord-305956-l02xdq87 2 24 date date NN cord-305956-l02xdq87 2 25 : : : cord-305956-l02xdq87 2 26 2020 2020 CD cord-305956-l02xdq87 2 27 - - HYPH cord-305956-l02xdq87 2 28 05 05 CD cord-305956-l02xdq87 2 29 - - SYM cord-305956-l02xdq87 2 30 26 26 CD cord-305956-l02xdq87 2 31 journal journal NN cord-305956-l02xdq87 2 32 : : : cord-305956-l02xdq87 2 33 United United NNP cord-305956-l02xdq87 2 34 European European NNP cord-305956-l02xdq87 2 35 Gastroenterol Gastroenterol NNP cord-305956-l02xdq87 2 36 J J NNP cord-305956-l02xdq87 2 37 DOI DOI NNP cord-305956-l02xdq87 2 38 : : : cord-305956-l02xdq87 2 39 10.1177/2050640620924157 10.1177/2050640620924157 CD cord-305956-l02xdq87 2 40 sha sha NNP cord-305956-l02xdq87 2 41 : : : cord-305956-l02xdq87 3 1 ad87636808fcce62fd2fe5f50c968b604dc21197 ad87636808fcce62fd2fe5f50c968b604dc21197 NNP cord-305956-l02xdq87 3 2 doc_id doc_id CD cord-305956-l02xdq87 3 3 : : : cord-305956-l02xdq87 4 1 305956 305956 CD cord-305956-l02xdq87 4 2 cord_uid cord_uid NNS cord-305956-l02xdq87 4 3 : : : cord-305956-l02xdq87 5 1 l02xdq87 l02xdq87 NNP cord-305956-l02xdq87 5 2 Patients Patients NNP cord-305956-l02xdq87 5 3 with with IN cord-305956-l02xdq87 5 4 novel novel JJ cord-305956-l02xdq87 5 5 coronavirus coronavirus NN cord-305956-l02xdq87 5 6 disease disease NN cord-305956-l02xdq87 5 7 2019 2019 CD cord-305956-l02xdq87 5 8 ( ( -LRB- cord-305956-l02xdq87 5 9 COVID-19 COVID-19 NNP cord-305956-l02xdq87 5 10 ) ) -RRB- cord-305956-l02xdq87 5 11 experience experience VB cord-305956-l02xdq87 5 12 various various JJ cord-305956-l02xdq87 5 13 degrees degree NNS cord-305956-l02xdq87 5 14 of of IN cord-305956-l02xdq87 5 15 liver liver NN cord-305956-l02xdq87 5 16 function function NN cord-305956-l02xdq87 5 17 abnormalities abnormality NNS cord-305956-l02xdq87 5 18 . . . cord-305956-l02xdq87 6 1 Liver liver NN cord-305956-l02xdq87 6 2 injury injury NN cord-305956-l02xdq87 6 3 requires require VBZ cord-305956-l02xdq87 6 4 extensive extensive JJ cord-305956-l02xdq87 6 5 work work NN cord-305956-l02xdq87 6 6 - - HYPH cord-305956-l02xdq87 6 7 up up NN cord-305956-l02xdq87 6 8 and and CC cord-305956-l02xdq87 6 9 continuous continuous JJ cord-305956-l02xdq87 6 10 surveillance surveillance NN cord-305956-l02xdq87 6 11 and and CC cord-305956-l02xdq87 6 12 can can MD cord-305956-l02xdq87 6 13 be be VB cord-305956-l02xdq87 6 14 multifactorial multifactorial JJ cord-305956-l02xdq87 6 15 and and CC cord-305956-l02xdq87 6 16 heterogeneous heterogeneous JJ cord-305956-l02xdq87 6 17 in in IN cord-305956-l02xdq87 6 18 nature nature NN cord-305956-l02xdq87 6 19 . . . cord-305956-l02xdq87 7 1 In in IN cord-305956-l02xdq87 7 2 the the DT cord-305956-l02xdq87 7 3 context context NN cord-305956-l02xdq87 7 4 of of IN cord-305956-l02xdq87 7 5 COVID-19 COVID-19 NNP cord-305956-l02xdq87 7 6 , , , cord-305956-l02xdq87 7 7 clinicians clinician NNS cord-305956-l02xdq87 7 8 will will MD cord-305956-l02xdq87 7 9 have have VB cord-305956-l02xdq87 7 10 to to TO cord-305956-l02xdq87 7 11 determine determine VB cord-305956-l02xdq87 7 12 whether whether IN cord-305956-l02xdq87 7 13 liver liver NN cord-305956-l02xdq87 7 14 injury injury NN cord-305956-l02xdq87 7 15 is be VBZ cord-305956-l02xdq87 7 16 related relate VBN cord-305956-l02xdq87 7 17 to to IN cord-305956-l02xdq87 7 18 an an DT cord-305956-l02xdq87 7 19 underlying underlying JJ cord-305956-l02xdq87 7 20 liver liver NN cord-305956-l02xdq87 7 21 disease disease NN cord-305956-l02xdq87 7 22 , , , cord-305956-l02xdq87 7 23 drugs drug NNS cord-305956-l02xdq87 7 24 used use VBN cord-305956-l02xdq87 7 25 for for IN cord-305956-l02xdq87 7 26 the the DT cord-305956-l02xdq87 7 27 treatment treatment NN cord-305956-l02xdq87 7 28 of of IN cord-305956-l02xdq87 7 29 COVID-19 COVID-19 NNP cord-305956-l02xdq87 7 30 , , , cord-305956-l02xdq87 7 31 direct direct JJ cord-305956-l02xdq87 7 32 effect effect NN cord-305956-l02xdq87 7 33 of of IN cord-305956-l02xdq87 7 34 the the DT cord-305956-l02xdq87 7 35 virus virus NN cord-305956-l02xdq87 7 36 , , , cord-305956-l02xdq87 7 37 or or CC cord-305956-l02xdq87 7 38 a a DT cord-305956-l02xdq87 7 39 complicated complicated JJ cord-305956-l02xdq87 7 40 disease disease NN cord-305956-l02xdq87 7 41 course course NN cord-305956-l02xdq87 7 42 . . . cord-305956-l02xdq87 8 1 Recent recent JJ cord-305956-l02xdq87 8 2 studies study NNS cord-305956-l02xdq87 8 3 proposed propose VBD cord-305956-l02xdq87 8 4 several several JJ cord-305956-l02xdq87 8 5 theories theory NNS cord-305956-l02xdq87 8 6 on on IN cord-305956-l02xdq87 8 7 potential potential JJ cord-305956-l02xdq87 8 8 mechanisms mechanism NNS cord-305956-l02xdq87 8 9 of of IN cord-305956-l02xdq87 8 10 liver liver NN cord-305956-l02xdq87 8 11 injury injury NN cord-305956-l02xdq87 8 12 in in IN cord-305956-l02xdq87 8 13 these these DT cord-305956-l02xdq87 8 14 patients patient NNS cord-305956-l02xdq87 8 15 . . . cord-305956-l02xdq87 9 1 This this DT cord-305956-l02xdq87 9 2 review review NN cord-305956-l02xdq87 9 3 summarizes summarize VBZ cord-305956-l02xdq87 9 4 current current JJ cord-305956-l02xdq87 9 5 evidence evidence NN cord-305956-l02xdq87 9 6 related relate VBN cord-305956-l02xdq87 9 7 to to IN cord-305956-l02xdq87 9 8 hepatobiliary hepatobiliary JJ cord-305956-l02xdq87 9 9 complications complication NNS cord-305956-l02xdq87 9 10 in in IN cord-305956-l02xdq87 9 11 COVID-19 COVID-19 NNP cord-305956-l02xdq87 9 12 , , , cord-305956-l02xdq87 9 13 provides provide VBZ cord-305956-l02xdq87 9 14 an an DT cord-305956-l02xdq87 9 15 overview overview NN cord-305956-l02xdq87 9 16 of of IN cord-305956-l02xdq87 9 17 the the DT cord-305956-l02xdq87 9 18 available available JJ cord-305956-l02xdq87 9 19 case case NN cord-305956-l02xdq87 9 20 series series NN cord-305956-l02xdq87 9 21 and and CC cord-305956-l02xdq87 9 22 critically critically RB cord-305956-l02xdq87 9 23 elucidates elucidate VBZ cord-305956-l02xdq87 9 24 the the DT cord-305956-l02xdq87 9 25 proposed propose VBN cord-305956-l02xdq87 9 26 mechanisms mechanism NNS cord-305956-l02xdq87 9 27 and and CC cord-305956-l02xdq87 9 28 provides provide VBZ cord-305956-l02xdq87 9 29 recommendations recommendation NNS cord-305956-l02xdq87 9 30 for for IN cord-305956-l02xdq87 9 31 clinicians clinician NNS cord-305956-l02xdq87 9 32 . . . cord-305956-l02xdq87 10 1 In in IN cord-305956-l02xdq87 10 2 the the DT cord-305956-l02xdq87 10 3 current current JJ cord-305956-l02xdq87 10 4 pandemic pandemic NN cord-305956-l02xdq87 10 5 coronavirus coronavirus NN cord-305956-l02xdq87 10 6 disease disease NN cord-305956-l02xdq87 10 7 ( ( -LRB- cord-305956-l02xdq87 10 8 COVID- covid- NN cord-305956-l02xdq87 10 9 19 19 CD cord-305956-l02xdq87 10 10 ) ) -RRB- cord-305956-l02xdq87 10 11 , , , cord-305956-l02xdq87 10 12 almost almost RB cord-305956-l02xdq87 10 13 every every DT cord-305956-l02xdq87 10 14 country country NN cord-305956-l02xdq87 10 15 in in IN cord-305956-l02xdq87 10 16 the the DT cord-305956-l02xdq87 10 17 world world NN cord-305956-l02xdq87 10 18 has have VBZ cord-305956-l02xdq87 10 19 now now RB cord-305956-l02xdq87 10 20 registered register VBN cord-305956-l02xdq87 10 21 COVID-19 covid-19 JJ cord-305956-l02xdq87 10 22 cases case NNS cord-305956-l02xdq87 10 23 , , , cord-305956-l02xdq87 10 24 and and CC cord-305956-l02xdq87 10 25 the the DT cord-305956-l02xdq87 10 26 confirmed confirm VBN cord-305956-l02xdq87 10 27 cases case NNS cord-305956-l02xdq87 10 28 have have VBP cord-305956-l02xdq87 10 29 exceeded exceed VBN cord-305956-l02xdq87 10 30 one one CD cord-305956-l02xdq87 10 31 million million CD cord-305956-l02xdq87 10 32 to to IN cord-305956-l02xdq87 10 33 date date NN cord-305956-l02xdq87 10 34 . . . cord-305956-l02xdq87 11 1 While while IN cord-305956-l02xdq87 11 2 initial initial JJ cord-305956-l02xdq87 11 3 clinical clinical JJ cord-305956-l02xdq87 11 4 studies study NNS cord-305956-l02xdq87 11 5 , , , cord-305956-l02xdq87 11 6 especially especially RB cord-305956-l02xdq87 11 7 from from IN cord-305956-l02xdq87 11 8 China China NNP cord-305956-l02xdq87 11 9 , , , cord-305956-l02xdq87 11 10 the the DT cord-305956-l02xdq87 11 11 USA USA NNP cord-305956-l02xdq87 11 12 and and CC cord-305956-l02xdq87 11 13 Italy Italy NNP cord-305956-l02xdq87 11 14 , , , cord-305956-l02xdq87 11 15 have have VBP cord-305956-l02xdq87 11 16 highlighted highlight VBN cord-305956-l02xdq87 11 17 the the DT cord-305956-l02xdq87 11 18 dominant dominant JJ cord-305956-l02xdq87 11 19 clinical clinical JJ cord-305956-l02xdq87 11 20 symptoms symptom NNS cord-305956-l02xdq87 11 21 including include VBG cord-305956-l02xdq87 11 22 fever fever NN cord-305956-l02xdq87 11 23 , , , cord-305956-l02xdq87 11 24 cough cough NN cord-305956-l02xdq87 11 25 , , , cord-305956-l02xdq87 11 26 fatigue fatigue NN cord-305956-l02xdq87 11 27 and and CC cord-305956-l02xdq87 11 28 shortness shortness NN cord-305956-l02xdq87 11 29 of of IN cord-305956-l02xdq87 11 30 breath breath NN cord-305956-l02xdq87 11 31 , , , cord-305956-l02xdq87 11 32 the the DT cord-305956-l02xdq87 11 33 later later JJ cord-305956-l02xdq87 11 34 research research NN cord-305956-l02xdq87 11 35 unveiled unveil VBD cord-305956-l02xdq87 11 36 shreds shred NNS cord-305956-l02xdq87 11 37 of of IN cord-305956-l02xdq87 11 38 evidence evidence NN cord-305956-l02xdq87 11 39 on on IN cord-305956-l02xdq87 11 40 the the DT cord-305956-l02xdq87 11 41 extrapulmonary extrapulmonary JJ cord-305956-l02xdq87 11 42 manifestations manifestation NNS cord-305956-l02xdq87 11 43 of of IN cord-305956-l02xdq87 11 44 the the DT cord-305956-l02xdq87 11 45 disease disease NN cord-305956-l02xdq87 11 46 . . . cord-305956-l02xdq87 12 1 These these DT cord-305956-l02xdq87 12 2 reports report NNS cord-305956-l02xdq87 12 3 highlighted highlight VBD cord-305956-l02xdq87 12 4 that that IN cord-305956-l02xdq87 12 5 beyond beyond IN cord-305956-l02xdq87 12 6 severe severe JJ cord-305956-l02xdq87 12 7 acute acute JJ cord-305956-l02xdq87 12 8 respiratory respiratory JJ cord-305956-l02xdq87 12 9 syndrome syndrome NN cord-305956-l02xdq87 12 10 coronavirus coronavirus NN cord-305956-l02xdq87 12 11 2 2 CD cord-305956-l02xdq87 12 12 ( ( -LRB- cord-305956-l02xdq87 12 13 SARS SARS NNP cord-305956-l02xdq87 12 14 - - HYPH cord-305956-l02xdq87 12 15 CoV-2 CoV-2 NNP cord-305956-l02xdq87 12 16 ) ) -RRB- cord-305956-l02xdq87 12 17 , , , cord-305956-l02xdq87 12 18 a a DT cord-305956-l02xdq87 12 19 complicated complicated JJ cord-305956-l02xdq87 12 20 course course NN cord-305956-l02xdq87 12 21 of of IN cord-305956-l02xdq87 12 22 the the DT cord-305956-l02xdq87 12 23 disease disease NN cord-305956-l02xdq87 12 24 or or CC cord-305956-l02xdq87 12 25 even even RB cord-305956-l02xdq87 12 26 viral viral JJ cord-305956-l02xdq87 12 27 infection infection NN cord-305956-l02xdq87 12 28 itself -PRON- PRP cord-305956-l02xdq87 12 29 can can MD cord-305956-l02xdq87 12 30 lead lead VB cord-305956-l02xdq87 12 31 to to IN cord-305956-l02xdq87 12 32 involvement involvement NN cord-305956-l02xdq87 12 33 of of IN cord-305956-l02xdq87 12 34 other other JJ cord-305956-l02xdq87 12 35 organs organ NNS cord-305956-l02xdq87 12 36 and and CC cord-305956-l02xdq87 12 37 multiorgan multiorgan NN cord-305956-l02xdq87 12 38 failure failure NN cord-305956-l02xdq87 12 39 . . . cord-305956-l02xdq87 13 1 The the DT cord-305956-l02xdq87 13 2 liver liver NN cord-305956-l02xdq87 13 3 is be VBZ cord-305956-l02xdq87 13 4 the the DT cord-305956-l02xdq87 13 5 primary primary JJ cord-305956-l02xdq87 13 6 organ organ NN cord-305956-l02xdq87 13 7 for for IN cord-305956-l02xdq87 13 8 detoxification detoxification NN cord-305956-l02xdq87 13 9 and and CC cord-305956-l02xdq87 13 10 metabolism metabolism NN cord-305956-l02xdq87 13 11 , , , cord-305956-l02xdq87 13 12 and and CC cord-305956-l02xdq87 13 13 maintaining maintain VBG cord-305956-l02xdq87 13 14 an an DT cord-305956-l02xdq87 13 15 optimal optimal JJ cord-305956-l02xdq87 13 16 function function NN cord-305956-l02xdq87 13 17 is be VBZ cord-305956-l02xdq87 13 18 imperative imperative JJ cord-305956-l02xdq87 13 19 to to TO cord-305956-l02xdq87 13 20 engage engage VB cord-305956-l02xdq87 13 21 all all DT cord-305956-l02xdq87 13 22 available available JJ cord-305956-l02xdq87 13 23 therapeutic therapeutic JJ cord-305956-l02xdq87 13 24 modalities modality NNS cord-305956-l02xdq87 13 25 in in IN cord-305956-l02xdq87 13 26 the the DT cord-305956-l02xdq87 13 27 treatment treatment NN cord-305956-l02xdq87 13 28 of of IN cord-305956-l02xdq87 13 29 COVID-19 COVID-19 NNP cord-305956-l02xdq87 13 30 . . . cord-305956-l02xdq87 14 1 Abnormal abnormal JJ cord-305956-l02xdq87 14 2 liver liver NN cord-305956-l02xdq87 14 3 function function NN cord-305956-l02xdq87 14 4 requires require VBZ cord-305956-l02xdq87 14 5 clinical clinical JJ cord-305956-l02xdq87 14 6 evaluation evaluation NN cord-305956-l02xdq87 14 7 , , , cord-305956-l02xdq87 14 8 continuous continuous JJ cord-305956-l02xdq87 14 9 surveillance surveillance NN cord-305956-l02xdq87 14 10 and and CC cord-305956-l02xdq87 14 11 , , , cord-305956-l02xdq87 14 12 potentially potentially RB cord-305956-l02xdq87 14 13 , , , cord-305956-l02xdq87 14 14 specific specific JJ cord-305956-l02xdq87 14 15 therapy therapy NN cord-305956-l02xdq87 14 16 . . . cord-305956-l02xdq87 15 1 To to TO cord-305956-l02xdq87 15 2 support support VB cord-305956-l02xdq87 15 3 clinical clinical JJ cord-305956-l02xdq87 15 4 decision decision NN cord-305956-l02xdq87 15 5 making making NN cord-305956-l02xdq87 15 6 and and CC cord-305956-l02xdq87 15 7 optimize optimize VB cord-305956-l02xdq87 15 8 the the DT cord-305956-l02xdq87 15 9 outcome outcome NN cord-305956-l02xdq87 15 10 in in IN cord-305956-l02xdq87 15 11 the the DT cord-305956-l02xdq87 15 12 treatment treatment NN cord-305956-l02xdq87 15 13 of of IN cord-305956-l02xdq87 15 14 COVID-19 COVID-19 NNP cord-305956-l02xdq87 15 15 , , , cord-305956-l02xdq87 15 16 it -PRON- PRP cord-305956-l02xdq87 15 17 will will MD cord-305956-l02xdq87 15 18 be be VB cord-305956-l02xdq87 15 19 crucial crucial JJ cord-305956-l02xdq87 15 20 to to TO cord-305956-l02xdq87 15 21 clearly clearly RB cord-305956-l02xdq87 15 22 understand understand VB cord-305956-l02xdq87 15 23 the the DT cord-305956-l02xdq87 15 24 possible possible JJ cord-305956-l02xdq87 15 25 mechanisms mechanism NNS cord-305956-l02xdq87 15 26 involved involve VBN cord-305956-l02xdq87 15 27 in in IN cord-305956-l02xdq87 15 28 liver liver NN cord-305956-l02xdq87 15 29 injury injury NN cord-305956-l02xdq87 15 30 . . . cord-305956-l02xdq87 16 1 The the DT cord-305956-l02xdq87 16 2 current current JJ cord-305956-l02xdq87 16 3 review review NN cord-305956-l02xdq87 16 4 summarizes summarize VBZ cord-305956-l02xdq87 16 5 the the DT cord-305956-l02xdq87 16 6 pathophysiology pathophysiology NN cord-305956-l02xdq87 16 7 and and CC cord-305956-l02xdq87 16 8 potentially potentially RB cord-305956-l02xdq87 16 9 specific specific JJ cord-305956-l02xdq87 16 10 role role NN cord-305956-l02xdq87 16 11 of of IN cord-305956-l02xdq87 16 12 COVID-19 COVID-19 NNP cord-305956-l02xdq87 16 13 in in IN cord-305956-l02xdq87 16 14 liver liver NN cord-305956-l02xdq87 16 15 disease disease NN cord-305956-l02xdq87 16 16 based base VBN cord-305956-l02xdq87 16 17 on on IN cord-305956-l02xdq87 16 18 the the DT cord-305956-l02xdq87 16 19 available available JJ cord-305956-l02xdq87 16 20 data datum NNS cord-305956-l02xdq87 16 21 and and CC cord-305956-l02xdq87 16 22 case case NN cord-305956-l02xdq87 16 23 series series NN cord-305956-l02xdq87 16 24 published publish VBN cord-305956-l02xdq87 16 25 , , , cord-305956-l02xdq87 16 26 ahead ahead RB cord-305956-l02xdq87 16 27 of of IN cord-305956-l02xdq87 16 28 print print NN cord-305956-l02xdq87 16 29 and and CC cord-305956-l02xdq87 16 30 non non JJ cord-305956-l02xdq87 16 31 - - JJ cord-305956-l02xdq87 16 32 peer peer NN cord-305956-l02xdq87 16 33 - - HYPH cord-305956-l02xdq87 16 34 reviewed review VBN cord-305956-l02xdq87 16 35 preprints preprint NNS cord-305956-l02xdq87 16 36 as as IN cord-305956-l02xdq87 16 37 of of IN cord-305956-l02xdq87 16 38 2 2 CD cord-305956-l02xdq87 16 39 April April NNP cord-305956-l02xdq87 16 40 . . . cord-305956-l02xdq87 17 1 The the DT cord-305956-l02xdq87 17 2 search search NN cord-305956-l02xdq87 17 3 strategy strategy NN cord-305956-l02xdq87 17 4 is be VBZ cord-305956-l02xdq87 17 5 detailed detail VBN cord-305956-l02xdq87 17 6 in in IN cord-305956-l02xdq87 17 7 the the DT cord-305956-l02xdq87 17 8 Supplementary Supplementary NNP cord-305956-l02xdq87 17 9 Material Material NNP cord-305956-l02xdq87 17 10 online online RB cord-305956-l02xdq87 17 11 . . . cord-305956-l02xdq87 18 1 Emerging emerge VBG cord-305956-l02xdq87 18 2 data datum NNS cord-305956-l02xdq87 18 3 from from IN cord-305956-l02xdq87 18 4 small small JJ cord-305956-l02xdq87 18 5 clinical clinical JJ cord-305956-l02xdq87 18 6 case case NN cord-305956-l02xdq87 18 7 studies study NNS cord-305956-l02xdq87 18 8 have have VBP cord-305956-l02xdq87 18 9 proposed propose VBN cord-305956-l02xdq87 18 10 that that IN cord-305956-l02xdq87 18 11 liver liver NN cord-305956-l02xdq87 18 12 injury injury NN cord-305956-l02xdq87 18 13 in in IN cord-305956-l02xdq87 18 14 COVID-19 COVID-19 NNP cord-305956-l02xdq87 18 15 is be VBZ cord-305956-l02xdq87 18 16 frequently frequently RB cord-305956-l02xdq87 18 17 seen see VBN cord-305956-l02xdq87 18 18 , , , cord-305956-l02xdq87 18 19 but but CC cord-305956-l02xdq87 18 20 the the DT cord-305956-l02xdq87 18 21 extent extent NN cord-305956-l02xdq87 18 22 and and CC cord-305956-l02xdq87 18 23 underlying underlying JJ cord-305956-l02xdq87 18 24 mechanisms mechanism NNS cord-305956-l02xdq87 18 25 remain remain VBP cord-305956-l02xdq87 18 26 undetermined undetermined JJ cord-305956-l02xdq87 18 27 . . . cord-305956-l02xdq87 19 1 Figure figure NN cord-305956-l02xdq87 19 2 1 1 CD cord-305956-l02xdq87 19 3 summarizes summarize VBZ cord-305956-l02xdq87 19 4 the the DT cord-305956-l02xdq87 19 5 pathophysiological pathophysiological JJ cord-305956-l02xdq87 19 6 findings finding NNS cord-305956-l02xdq87 19 7 , , , cord-305956-l02xdq87 19 8 which which WDT cord-305956-l02xdq87 19 9 are be VBP cord-305956-l02xdq87 19 10 discussed discuss VBN cord-305956-l02xdq87 19 11 below below RB cord-305956-l02xdq87 19 12 . . . cord-305956-l02xdq87 20 1 The the DT cord-305956-l02xdq87 20 2 liver liver NN cord-305956-l02xdq87 20 3 exerts exert VBZ cord-305956-l02xdq87 20 4 a a DT cord-305956-l02xdq87 20 5 crucial crucial JJ cord-305956-l02xdq87 20 6 function function NN cord-305956-l02xdq87 20 7 in in IN cord-305956-l02xdq87 20 8 host host NN cord-305956-l02xdq87 20 9 defense defense NN cord-305956-l02xdq87 20 10 against against IN cord-305956-l02xdq87 20 11 microbes microbe NNS cord-305956-l02xdq87 20 12 and and CC cord-305956-l02xdq87 20 13 is be VBZ cord-305956-l02xdq87 20 14 involved involve VBN cord-305956-l02xdq87 20 15 in in IN cord-305956-l02xdq87 20 16 most most JJS cord-305956-l02xdq87 20 17 systemic systemic JJ cord-305956-l02xdq87 20 18 infections infection NNS cord-305956-l02xdq87 20 19 as as IN cord-305956-l02xdq87 20 20 it -PRON- PRP cord-305956-l02xdq87 20 21 receives receive VBZ cord-305956-l02xdq87 20 22 both both CC cord-305956-l02xdq87 20 23 the the DT cord-305956-l02xdq87 20 24 portal portal JJ cord-305956-l02xdq87 20 25 and and CC cord-305956-l02xdq87 20 26 systemic systemic JJ cord-305956-l02xdq87 20 27 circulation circulation NN cord-305956-l02xdq87 20 28 . . . cord-305956-l02xdq87 21 1 Certain certain JJ cord-305956-l02xdq87 21 2 viruses virus NNS cord-305956-l02xdq87 21 3 exert exert VBP cord-305956-l02xdq87 21 4 a a DT cord-305956-l02xdq87 21 5 direct direct JJ cord-305956-l02xdq87 21 6 cytopathic cytopathic JJ cord-305956-l02xdq87 21 7 effect effect NN cord-305956-l02xdq87 21 8 on on IN cord-305956-l02xdq87 21 9 hepatocytes hepatocyte NNS cord-305956-l02xdq87 21 10 and and CC cord-305956-l02xdq87 21 11 cholangiocytes cholangiocyte NNS cord-305956-l02xdq87 21 12 although although IN cord-305956-l02xdq87 21 13 , , , cord-305956-l02xdq87 21 14 in in IN cord-305956-l02xdq87 21 15 most most JJS cord-305956-l02xdq87 21 16 cases case NNS cord-305956-l02xdq87 21 17 , , , cord-305956-l02xdq87 21 18 the the DT cord-305956-l02xdq87 21 19 pathogenesis pathogenesis NN cord-305956-l02xdq87 21 20 seems seem VBZ cord-305956-l02xdq87 21 21 multifactorial multifactorial JJ cord-305956-l02xdq87 21 22 . . . cord-305956-l02xdq87 22 1 Yang Yang NNP cord-305956-l02xdq87 22 2 et et NNP cord-305956-l02xdq87 22 3 al al NNP cord-305956-l02xdq87 22 4 . . NNP cord-305956-l02xdq87 22 5 reported report VBD cord-305956-l02xdq87 22 6 that that IN cord-305956-l02xdq87 22 7 SARS SARS NNP cord-305956-l02xdq87 22 8 - - HYPH cord-305956-l02xdq87 22 9 CoV CoV NNP cord-305956-l02xdq87 22 10 could could MD cord-305956-l02xdq87 22 11 cause cause VB cord-305956-l02xdq87 22 12 direct direct JJ cord-305956-l02xdq87 22 13 cytopathic cytopathic JJ cord-305956-l02xdq87 22 14 liver liver NN cord-305956-l02xdq87 22 15 injury injury NN cord-305956-l02xdq87 22 16 rather rather RB cord-305956-l02xdq87 22 17 than than IN cord-305956-l02xdq87 22 18 inducing induce VBG cord-305956-l02xdq87 22 19 cellular cellular JJ cord-305956-l02xdq87 22 20 stress stress NN cord-305956-l02xdq87 22 21 from from IN cord-305956-l02xdq87 22 22 low low JJ cord-305956-l02xdq87 22 23 oxygen oxygen NN cord-305956-l02xdq87 22 24 supplies supply NNS cord-305956-l02xdq87 22 25 or or CC cord-305956-l02xdq87 22 26 cytokines cytokine NNS cord-305956-l02xdq87 22 27 as as IN cord-305956-l02xdq87 22 28 seen see VBN cord-305956-l02xdq87 22 29 in in IN cord-305956-l02xdq87 22 30 sepsis sepsis NN cord-305956-l02xdq87 22 31 . . . cord-305956-l02xdq87 23 1 1 1 LS cord-305956-l02xdq87 24 1 Autopsy autopsy JJ cord-305956-l02xdq87 24 2 studies study NNS cord-305956-l02xdq87 24 3 in in IN cord-305956-l02xdq87 24 4 patients patient NNS cord-305956-l02xdq87 24 5 revealed reveal VBD cord-305956-l02xdq87 24 6 that that IN cord-305956-l02xdq87 24 7 SARS SARS NNP cord-305956-l02xdq87 24 8 - - HYPH cord-305956-l02xdq87 24 9 CoV CoV NNP cord-305956-l02xdq87 24 10 was be VBD cord-305956-l02xdq87 24 11 detectable detectable JJ cord-305956-l02xdq87 24 12 in in IN cord-305956-l02xdq87 24 13 41 41 CD cord-305956-l02xdq87 24 14 % % NN cord-305956-l02xdq87 24 15 of of IN cord-305956-l02xdq87 24 16 the the DT cord-305956-l02xdq87 24 17 liver liver NN cord-305956-l02xdq87 24 18 tissue tissue NN cord-305956-l02xdq87 24 19 , , , cord-305956-l02xdq87 24 20 with with IN cord-305956-l02xdq87 24 21 a a DT cord-305956-l02xdq87 24 22 maximum maximum JJ cord-305956-l02xdq87 24 23 viral viral JJ cord-305956-l02xdq87 24 24 load load NN cord-305956-l02xdq87 24 25 of of IN cord-305956-l02xdq87 24 26 1.6 1.6 CD cord-305956-l02xdq87 24 27 Â â CD cord-305956-l02xdq87 24 28 10 10 CD cord-305956-l02xdq87 24 29 6 6 CD cord-305956-l02xdq87 24 30 copies copy NNS cord-305956-l02xdq87 24 31 / / SYM cord-305956-l02xdq87 24 32 g g NN cord-305956-l02xdq87 24 33 of of IN cord-305956-l02xdq87 24 34 tissue tissue NN cord-305956-l02xdq87 24 35 . . . cord-305956-l02xdq87 25 1 2 2 LS cord-305956-l02xdq87 26 1 The the DT cord-305956-l02xdq87 26 2 pathological pathological JJ cord-305956-l02xdq87 26 3 findings finding NNS cord-305956-l02xdq87 26 4 of of IN cord-305956-l02xdq87 26 5 liver liver NN cord-305956-l02xdq87 26 6 biopsy biopsy NN cord-305956-l02xdq87 26 7 specimens specimen NNS cord-305956-l02xdq87 26 8 from from IN cord-305956-l02xdq87 26 9 SARS SARS NNP cord-305956-l02xdq87 26 10 patients patient NNS cord-305956-l02xdq87 26 11 showed show VBD cord-305956-l02xdq87 26 12 hepatocellular hepatocellular JJ cord-305956-l02xdq87 26 13 necrosis necrosis NN cord-305956-l02xdq87 26 14 , , , cord-305956-l02xdq87 26 15 mitoses mitose NNS cord-305956-l02xdq87 26 16 , , , cord-305956-l02xdq87 26 17 cellular cellular JJ cord-305956-l02xdq87 26 18 infiltration infiltration NN cord-305956-l02xdq87 26 19 and and CC cord-305956-l02xdq87 26 20 fatty fatty JJ cord-305956-l02xdq87 26 21 degeneration degeneration NN cord-305956-l02xdq87 26 22 . . . cord-305956-l02xdq87 27 1 In in IN cord-305956-l02xdq87 27 2 a a DT cord-305956-l02xdq87 27 3 recent recent JJ cord-305956-l02xdq87 27 4 autopsy autopsy JJ cord-305956-l02xdq87 27 5 analysis analysis NN cord-305956-l02xdq87 27 6 of of IN cord-305956-l02xdq87 27 7 liver liver NN cord-305956-l02xdq87 27 8 tissue tissue NN cord-305956-l02xdq87 27 9 from from IN cord-305956-l02xdq87 27 10 a a DT cord-305956-l02xdq87 27 11 patient patient NN cord-305956-l02xdq87 27 12 with with IN cord-305956-l02xdq87 27 13 COVID-19 COVID-19 NNP cord-305956-l02xdq87 27 14 , , , cord-305956-l02xdq87 27 15 moderate moderate JJ cord-305956-l02xdq87 27 16 microvesicular microvesicular JJ cord-305956-l02xdq87 27 17 steatosis steatosis NN cord-305956-l02xdq87 27 18 and and CC cord-305956-l02xdq87 27 19 mild mild JJ cord-305956-l02xdq87 27 20 inflammation inflammation NN cord-305956-l02xdq87 27 21 in in IN cord-305956-l02xdq87 27 22 the the DT cord-305956-l02xdq87 27 23 lobular lobular NNP cord-305956-l02xdq87 27 24 and and CC cord-305956-l02xdq87 27 25 portal portal JJ cord-305956-l02xdq87 27 26 area area NN cord-305956-l02xdq87 27 27 was be VBD cord-305956-l02xdq87 27 28 observed observe VBN cord-305956-l02xdq87 27 29 . . . cord-305956-l02xdq87 28 1 However however RB cord-305956-l02xdq87 28 2 , , , cord-305956-l02xdq87 28 3 this this DT cord-305956-l02xdq87 28 4 pattern pattern NN cord-305956-l02xdq87 28 5 of of IN cord-305956-l02xdq87 28 6 histological histological JJ cord-305956-l02xdq87 28 7 injury injury NN cord-305956-l02xdq87 28 8 is be VBZ cord-305956-l02xdq87 28 9 not not RB cord-305956-l02xdq87 28 10 specific specific JJ cord-305956-l02xdq87 28 11 for for IN cord-305956-l02xdq87 28 12 one one CD cord-305956-l02xdq87 28 13 etiology etiology NN cord-305956-l02xdq87 28 14 but but CC cord-305956-l02xdq87 28 15 can can MD cord-305956-l02xdq87 28 16 also also RB cord-305956-l02xdq87 28 17 be be VB cord-305956-l02xdq87 28 18 observed observe VBN cord-305956-l02xdq87 28 19 during during IN cord-305956-l02xdq87 28 20 sepsis sepsis NN cord-305956-l02xdq87 28 21 or or CC cord-305956-l02xdq87 28 22 drug drug NN cord-305956-l02xdq87 28 23 - - HYPH cord-305956-l02xdq87 28 24 induced induce VBN cord-305956-l02xdq87 28 25 liver liver NN cord-305956-l02xdq87 28 26 injury injury NN cord-305956-l02xdq87 28 27 ( ( -LRB- cord-305956-l02xdq87 28 28 DILI DILI NNP cord-305956-l02xdq87 28 29 ) ) -RRB- cord-305956-l02xdq87 28 30 . . . cord-305956-l02xdq87 29 1 3 3 CD cord-305956-l02xdq87 29 2 _SP cord-305956-l02xdq87 30 1 Similar similar JJ cord-305956-l02xdq87 30 2 to to IN cord-305956-l02xdq87 30 3 SARS SARS NNP cord-305956-l02xdq87 30 4 - - HYPH cord-305956-l02xdq87 30 5 CoV CoV NNP cord-305956-l02xdq87 30 6 , , , cord-305956-l02xdq87 30 7 SARS SARS NNP cord-305956-l02xdq87 30 8 - - HYPH cord-305956-l02xdq87 30 9 CoV-2 CoV-2 NNP cord-305956-l02xdq87 30 10 uses use VBZ cord-305956-l02xdq87 30 11 the the DT cord-305956-l02xdq87 30 12 angiotensin-2 angiotensin-2 NNP cord-305956-l02xdq87 30 13 converting convert VBG cord-305956-l02xdq87 30 14 enzyme enzyme NN cord-305956-l02xdq87 30 15 ( ( -LRB- cord-305956-l02xdq87 30 16 ACE2 ACE2 NNP cord-305956-l02xdq87 30 17 ) ) -RRB- cord-305956-l02xdq87 30 18 receptor receptor NN cord-305956-l02xdq87 30 19 protein protein NN cord-305956-l02xdq87 30 20 to to TO cord-305956-l02xdq87 30 21 attack attack VB cord-305956-l02xdq87 30 22 the the DT cord-305956-l02xdq87 30 23 host host NN cord-305956-l02xdq87 30 24 system system NN cord-305956-l02xdq87 30 25 . . . cord-305956-l02xdq87 31 1 4 4 LS cord-305956-l02xdq87 32 1 The the DT cord-305956-l02xdq87 32 2 cell cell NN cord-305956-l02xdq87 32 3 entry entry NN cord-305956-l02xdq87 32 4 receptor receptor NN cord-305956-l02xdq87 32 5 , , , cord-305956-l02xdq87 32 6 ACE2 ACE2 NNP cord-305956-l02xdq87 32 7 , , , cord-305956-l02xdq87 32 8 is be VBZ cord-305956-l02xdq87 32 9 widely widely RB cord-305956-l02xdq87 32 10 expressed express VBN cord-305956-l02xdq87 32 11 across across IN cord-305956-l02xdq87 32 12 the the DT cord-305956-l02xdq87 32 13 human human JJ cord-305956-l02xdq87 32 14 body body NN cord-305956-l02xdq87 32 15 , , , cord-305956-l02xdq87 32 16 including include VBG cord-305956-l02xdq87 32 17 the the DT cord-305956-l02xdq87 32 18 lungs lung NNS cord-305956-l02xdq87 32 19 ( ( -LRB- cord-305956-l02xdq87 32 20 type type NN cord-305956-l02xdq87 32 21 II ii CD cord-305956-l02xdq87 32 22 alveolar alveolar NN cord-305956-l02xdq87 32 23 cells cell NNS cord-305956-l02xdq87 32 24 ) ) -RRB- cord-305956-l02xdq87 32 25 , , , cord-305956-l02xdq87 32 26 gastrointestinal gastrointestinal JJ cord-305956-l02xdq87 32 27 tract tract NN cord-305956-l02xdq87 32 28 ( ( -LRB- cord-305956-l02xdq87 32 29 esophageal esophageal JJ cord-305956-l02xdq87 32 30 epithelial epithelial JJ cord-305956-l02xdq87 32 31 cells cell NNS cord-305956-l02xdq87 32 32 and and CC cord-305956-l02xdq87 32 33 absorptive absorptive JJ cord-305956-l02xdq87 32 34 enterocytes enterocyte NNS cord-305956-l02xdq87 32 35 of of IN cord-305956-l02xdq87 32 36 ileum ileum NN cord-305956-l02xdq87 32 37 and and CC cord-305956-l02xdq87 32 38 colon colon NN cord-305956-l02xdq87 32 39 ) ) -RRB- cord-305956-l02xdq87 32 40 , , , cord-305956-l02xdq87 32 41 hepatobiliary hepatobiliary JJ cord-305956-l02xdq87 32 42 system system NN cord-305956-l02xdq87 32 43 ( ( -LRB- cord-305956-l02xdq87 32 44 hepatocytes hepatocyte NNS cord-305956-l02xdq87 32 45 and and CC cord-305956-l02xdq87 32 46 cholangiocytes cholangiocyte NNS cord-305956-l02xdq87 32 47 ) ) -RRB- cord-305956-l02xdq87 32 48 , , , cord-305956-l02xdq87 32 49 cardiovascular cardiovascular JJ cord-305956-l02xdq87 32 50 system system NN cord-305956-l02xdq87 32 51 ( ( -LRB- cord-305956-l02xdq87 32 52 myocardial myocardial JJ cord-305956-l02xdq87 32 53 cells cell NNS cord-305956-l02xdq87 32 54 ) ) -RRB- cord-305956-l02xdq87 32 55 , , , cord-305956-l02xdq87 32 56 the the DT cord-305956-l02xdq87 32 57 renal renal JJ cord-305956-l02xdq87 32 58 system system NN cord-305956-l02xdq87 32 59 ( ( -LRB- cord-305956-l02xdq87 32 60 proximal proximal JJ cord-305956-l02xdq87 32 61 tubule tubule NN cord-305956-l02xdq87 32 62 cells cell NNS cord-305956-l02xdq87 32 63 and and CC cord-305956-l02xdq87 32 64 urothelial urothelial JJ cord-305956-l02xdq87 32 65 bladder bladder NN cord-305956-l02xdq87 32 66 cells cell NNS cord-305956-l02xdq87 32 67 ) ) -RRB- cord-305956-l02xdq87 32 68 and and CC cord-305956-l02xdq87 32 69 the the DT cord-305956-l02xdq87 32 70 pancreas pancrea NNS cord-305956-l02xdq87 32 71 . . . cord-305956-l02xdq87 33 1 5 5 LS cord-305956-l02xdq87 34 1 Recent recent JJ cord-305956-l02xdq87 34 2 studies study NNS cord-305956-l02xdq87 34 3 have have VBP cord-305956-l02xdq87 34 4 observed observe VBN cord-305956-l02xdq87 34 5 that that IN cord-305956-l02xdq87 34 6 ACE2 ACE2 NNP cord-305956-l02xdq87 34 7 expression expression NN cord-305956-l02xdq87 34 8 in in IN cord-305956-l02xdq87 34 9 the the DT cord-305956-l02xdq87 34 10 cell cell NN cord-305956-l02xdq87 34 11 clusters cluster NNS cord-305956-l02xdq87 34 12 of of IN cord-305956-l02xdq87 34 13 cholangiocytes cholangiocyte NNS cord-305956-l02xdq87 34 14 was be VBD cord-305956-l02xdq87 34 15 significantly significantly RB cord-305956-l02xdq87 34 16 higher high JJR cord-305956-l02xdq87 34 17 than than IN cord-305956-l02xdq87 34 18 that that DT cord-305956-l02xdq87 34 19 in in IN cord-305956-l02xdq87 34 20 the the DT cord-305956-l02xdq87 34 21 hepatocytes hepatocyte NNS cord-305956-l02xdq87 34 22 population population NN cord-305956-l02xdq87 34 23 ( ( -LRB- cord-305956-l02xdq87 34 24 59.7 59.7 CD cord-305956-l02xdq87 34 25 % % NN cord-305956-l02xdq87 34 26 vs. vs. IN cord-305956-l02xdq87 34 27 2.6 2.6 CD cord-305956-l02xdq87 34 28 % % NN cord-305956-l02xdq87 34 29 ) ) -RRB- cord-305956-l02xdq87 34 30 . . . cord-305956-l02xdq87 35 1 6 6 CD cord-305956-l02xdq87 36 1 The the DT cord-305956-l02xdq87 36 2 authors author NNS cord-305956-l02xdq87 36 3 conclude conclude VBP cord-305956-l02xdq87 36 4 that that IN cord-305956-l02xdq87 36 5 SARS SARS NNP cord-305956-l02xdq87 36 6 - - HYPH cord-305956-l02xdq87 36 7 CoV-2 CoV-2 NNP cord-305956-l02xdq87 36 8 may may MD cord-305956-l02xdq87 36 9 directly directly RB cord-305956-l02xdq87 36 10 bind bind VB cord-305956-l02xdq87 36 11 to to IN cord-305956-l02xdq87 36 12 ACE2 ACE2 NNP cord-305956-l02xdq87 36 13 positive positive JJ cord-305956-l02xdq87 36 14 cholangiocytes cholangiocyte NNS cord-305956-l02xdq87 36 15 , , , cord-305956-l02xdq87 36 16 but but CC cord-305956-l02xdq87 36 17 not not RB cord-305956-l02xdq87 36 18 hepatocytes hepatocyte NNS cord-305956-l02xdq87 36 19 , , , cord-305956-l02xdq87 36 20 to to TO cord-305956-l02xdq87 36 21 exert exert VB cord-305956-l02xdq87 36 22 a a DT cord-305956-l02xdq87 36 23 cytopathic cytopathic JJ cord-305956-l02xdq87 36 24 effect effect NN cord-305956-l02xdq87 36 25 . . . cord-305956-l02xdq87 37 1 Cholangiocytes cholangiocyte NNS cord-305956-l02xdq87 37 2 are be VBP cord-305956-l02xdq87 37 3 involved involve VBN cord-305956-l02xdq87 37 4 in in IN cord-305956-l02xdq87 37 5 many many JJ cord-305956-l02xdq87 37 6 aspects aspect NNS cord-305956-l02xdq87 37 7 of of IN cord-305956-l02xdq87 37 8 liver liver NN cord-305956-l02xdq87 37 9 physiology physiology NN cord-305956-l02xdq87 37 10 , , , cord-305956-l02xdq87 37 11 including include VBG cord-305956-l02xdq87 37 12 regeneration regeneration NN cord-305956-l02xdq87 37 13 and and CC cord-305956-l02xdq87 37 14 adaptive adaptive JJ cord-305956-l02xdq87 37 15 immune immune JJ cord-305956-l02xdq87 37 16 response response NN cord-305956-l02xdq87 37 17 mechanisms mechanism NNS cord-305956-l02xdq87 37 18 , , , cord-305956-l02xdq87 37 19 and and CC cord-305956-l02xdq87 37 20 the the DT cord-305956-l02xdq87 37 21 disruption disruption NN cord-305956-l02xdq87 37 22 of of IN cord-305956-l02xdq87 37 23 cholangiocyte cholangiocyte NNP cord-305956-l02xdq87 37 24 function function NN cord-305956-l02xdq87 37 25 can can MD cord-305956-l02xdq87 37 26 cause cause VB cord-305956-l02xdq87 37 27 hepatobiliary hepatobiliary JJ cord-305956-l02xdq87 37 28 damage damage NN cord-305956-l02xdq87 37 29 . . . cord-305956-l02xdq87 38 1 This this DT cord-305956-l02xdq87 38 2 is be VBZ cord-305956-l02xdq87 38 3 supported support VBN cord-305956-l02xdq87 38 4 by by IN cord-305956-l02xdq87 38 5 cholestatic cholestatic JJ cord-305956-l02xdq87 38 6 markers marker NNS cord-305956-l02xdq87 38 7 , , , cord-305956-l02xdq87 38 8 including include VBG cord-305956-l02xdq87 38 9 gamma gamma NN cord-305956-l02xdq87 38 10 - - HYPH cord-305956-l02xdq87 38 11 glutamyl glutamyl NN cord-305956-l02xdq87 38 12 transferase transferase NN cord-305956-l02xdq87 38 13 ( ( -LRB- cord-305956-l02xdq87 38 14 GGT GGT NNP cord-305956-l02xdq87 38 15 ) ) -RRB- cord-305956-l02xdq87 38 16 , , , cord-305956-l02xdq87 38 17 that that WDT cord-305956-l02xdq87 38 18 can can MD cord-305956-l02xdq87 38 19 be be VB cord-305956-l02xdq87 38 20 found find VBN cord-305956-l02xdq87 38 21 in in IN cord-305956-l02xdq87 38 22 some some DT cord-305956-l02xdq87 38 23 , , , cord-305956-l02xdq87 38 24 but but CC cord-305956-l02xdq87 38 25 not not RB cord-305956-l02xdq87 38 26 all all DT cord-305956-l02xdq87 38 27 , , , cord-305956-l02xdq87 38 28 case case NN cord-305956-l02xdq87 38 29 series series NN cord-305956-l02xdq87 38 30 of of IN cord-305956-l02xdq87 38 31 COVID-19 COVID-19 NNP cord-305956-l02xdq87 38 32 . . . cord-305956-l02xdq87 39 1 [ [ -LRB- cord-305956-l02xdq87 39 2 7 7 CD cord-305956-l02xdq87 39 3 ] ] -RRB- cord-305956-l02xdq87 39 4 [ [ -LRB- cord-305956-l02xdq87 39 5 8 8 CD cord-305956-l02xdq87 39 6 ] ] -RRB- cord-305956-l02xdq87 39 7 [ [ -LRB- cord-305956-l02xdq87 39 8 9 9 CD cord-305956-l02xdq87 39 9 ] ] -RRB- cord-305956-l02xdq87 40 1 Notably notably RB cord-305956-l02xdq87 40 2 , , , cord-305956-l02xdq87 40 3 a a DT cord-305956-l02xdq87 40 4 recent recent JJ cord-305956-l02xdq87 40 5 review review NN cord-305956-l02xdq87 40 6 reported report VBD cord-305956-l02xdq87 40 7 unpublished unpublished JJ cord-305956-l02xdq87 40 8 data datum NNS cord-305956-l02xdq87 40 9 with with IN cord-305956-l02xdq87 40 10 GGT GGT NNP cord-305956-l02xdq87 40 11 elevations elevation NNS cord-305956-l02xdq87 40 12 in in IN cord-305956-l02xdq87 40 13 54 54 CD cord-305956-l02xdq87 40 14 % % NN cord-305956-l02xdq87 40 15 of of IN cord-305956-l02xdq87 40 16 cases case NNS cord-305956-l02xdq87 40 17 . . . cord-305956-l02xdq87 41 1 8 8 CD cord-305956-l02xdq87 42 1 In in IN cord-305956-l02xdq87 42 2 a a DT cord-305956-l02xdq87 42 3 human human JJ cord-305956-l02xdq87 42 4 organoid organoid NN cord-305956-l02xdq87 42 5 model model NN cord-305956-l02xdq87 42 6 of of IN cord-305956-l02xdq87 42 7 liver liver NN cord-305956-l02xdq87 42 8 ductal ductal JJ cord-305956-l02xdq87 42 9 organoids organoid NNS cord-305956-l02xdq87 42 10 , , , cord-305956-l02xdq87 42 11 permissiveness permissiveness NN cord-305956-l02xdq87 42 12 to to IN cord-305956-l02xdq87 42 13 SARS SARS NNP cord-305956-l02xdq87 42 14 - - HYPH cord-305956-l02xdq87 42 15 CoV-2 CoV-2 NNP cord-305956-l02xdq87 42 16 infection infection NN cord-305956-l02xdq87 42 17 was be VBD cord-305956-l02xdq87 42 18 observed observe VBN cord-305956-l02xdq87 42 19 . . . cord-305956-l02xdq87 43 1 Here here RB cord-305956-l02xdq87 43 2 viral viral JJ cord-305956-l02xdq87 43 3 infection infection NN cord-305956-l02xdq87 43 4 impaired impair VBD cord-305956-l02xdq87 43 5 the the DT cord-305956-l02xdq87 43 6 barrier barrier NN cord-305956-l02xdq87 43 7 and and CC cord-305956-l02xdq87 43 8 bile bile NN cord-305956-l02xdq87 43 9 acid acid NN cord-305956-l02xdq87 43 10 transporting transporting NN cord-305956-l02xdq87 43 11 functions function NNS cord-305956-l02xdq87 43 12 of of IN cord-305956-l02xdq87 43 13 cholangiocytes cholangiocyte NNS cord-305956-l02xdq87 43 14 through through IN cord-305956-l02xdq87 43 15 dysregulation dysregulation NN cord-305956-l02xdq87 43 16 of of IN cord-305956-l02xdq87 43 17 genes gene NNS cord-305956-l02xdq87 43 18 involved involve VBN cord-305956-l02xdq87 43 19 in in IN cord-305956-l02xdq87 43 20 tight tight JJ cord-305956-l02xdq87 43 21 junction junction NN cord-305956-l02xdq87 43 22 formation formation NN cord-305956-l02xdq87 43 23 and and CC cord-305956-l02xdq87 43 24 bile bile NN cord-305956-l02xdq87 43 25 acid acid NN cord-305956-l02xdq87 43 26 transportation transportation NN cord-305956-l02xdq87 43 27 , , , cord-305956-l02xdq87 43 28 supporting support VBG cord-305956-l02xdq87 43 29 the the DT cord-305956-l02xdq87 43 30 susceptibility susceptibility NN cord-305956-l02xdq87 43 31 of of IN cord-305956-l02xdq87 43 32 cholangiocytes cholangiocyte NNS cord-305956-l02xdq87 43 33 in in IN cord-305956-l02xdq87 43 34 SARS SARS NNP cord-305956-l02xdq87 43 35 - - HYPH cord-305956-l02xdq87 43 36 CoV-2-related cov-2-relate VBN cord-305956-l02xdq87 43 37 liver liver NN cord-305956-l02xdq87 43 38 injury injury NN cord-305956-l02xdq87 43 39 . . . cord-305956-l02xdq87 44 1 10 10 CD cord-305956-l02xdq87 44 2 Activation activation NN cord-305956-l02xdq87 44 3 of of IN cord-305956-l02xdq87 44 4 the the DT cord-305956-l02xdq87 44 5 immune immune JJ cord-305956-l02xdq87 44 6 system system NN cord-305956-l02xdq87 44 7 in in IN cord-305956-l02xdq87 44 8 COVID-19 COVID-19 NNP cord-305956-l02xdq87 44 9 Dysregulation Dysregulation NNP cord-305956-l02xdq87 44 10 of of IN cord-305956-l02xdq87 44 11 the the DT cord-305956-l02xdq87 44 12 innate innate JJ cord-305956-l02xdq87 44 13 immune immune JJ cord-305956-l02xdq87 44 14 response response NN cord-305956-l02xdq87 44 15 can can MD cord-305956-l02xdq87 44 16 be be VB cord-305956-l02xdq87 44 17 one one CD cord-305956-l02xdq87 44 18 aspect aspect NN cord-305956-l02xdq87 44 19 of of IN cord-305956-l02xdq87 44 20 liver liver NN cord-305956-l02xdq87 44 21 injury injury NN cord-305956-l02xdq87 44 22 in in IN cord-305956-l02xdq87 44 23 COVID-19 COVID-19 NNP cord-305956-l02xdq87 44 24 . . . cord-305956-l02xdq87 45 1 Patients patient NNS cord-305956-l02xdq87 45 2 with with IN cord-305956-l02xdq87 45 3 COVID-19 covid-19 DT cord-305956-l02xdq87 45 4 exhibit exhibit NN cord-305956-l02xdq87 45 5 marked marked JJ cord-305956-l02xdq87 45 6 activation activation NN cord-305956-l02xdq87 45 7 of of IN cord-305956-l02xdq87 45 8 inflammatory inflammatory JJ cord-305956-l02xdq87 45 9 markers marker NNS cord-305956-l02xdq87 45 10 , , , cord-305956-l02xdq87 45 11 including include VBG cord-305956-l02xdq87 45 12 abnormal abnormal JJ cord-305956-l02xdq87 45 13 levels level NNS cord-305956-l02xdq87 45 14 of of IN cord-305956-l02xdq87 45 15 C c NN cord-305956-l02xdq87 45 16 - - HYPH cord-305956-l02xdq87 45 17 reactive reactive JJ cord-305956-l02xdq87 45 18 protein protein NN cord-305956-l02xdq87 45 19 ( ( -LRB- cord-305956-l02xdq87 45 20 CRP CRP NNP cord-305956-l02xdq87 45 21 ) ) -RRB- cord-305956-l02xdq87 45 22 , , , cord-305956-l02xdq87 45 23 lymphocytes lymphocyte NNS cord-305956-l02xdq87 45 24 , , , cord-305956-l02xdq87 45 25 neutrophils neutrophil NNS cord-305956-l02xdq87 45 26 and and CC cord-305956-l02xdq87 45 27 cytokines cytokine NNS cord-305956-l02xdq87 45 28 , , , cord-305956-l02xdq87 45 29 in in IN cord-305956-l02xdq87 45 30 particular particular JJ cord-305956-l02xdq87 45 31 interleukin-6 interleukin-6 NNP cord-305956-l02xdq87 46 1 ( ( -LRB- cord-305956-l02xdq87 46 2 IL-6 IL-6 NNP cord-305956-l02xdq87 46 3 ) ) -RRB- cord-305956-l02xdq87 46 4 . . . cord-305956-l02xdq87 47 1 8 8 CD cord-305956-l02xdq87 47 2 , , , cord-305956-l02xdq87 47 3 [ [ -LRB- cord-305956-l02xdq87 47 4 11 11 CD cord-305956-l02xdq87 47 5 ] ] -RRB- cord-305956-l02xdq87 47 6 [ [ -LRB- cord-305956-l02xdq87 47 7 12 12 CD cord-305956-l02xdq87 47 8 ] ] -RRB- cord-305956-l02xdq87 47 9 [ [ -LRB- cord-305956-l02xdq87 47 10 13 13 CD cord-305956-l02xdq87 47 11 ] ] -RRB- cord-305956-l02xdq87 48 1 These these DT cord-305956-l02xdq87 48 2 mechanisms mechanism NNS cord-305956-l02xdq87 48 3 may may MD cord-305956-l02xdq87 48 4 contribute contribute VB cord-305956-l02xdq87 48 5 to to IN cord-305956-l02xdq87 48 6 pulmonary pulmonary JJ cord-305956-l02xdq87 48 7 and and CC cord-305956-l02xdq87 48 8 extrapulmonary extrapulmonary JJ cord-305956-l02xdq87 48 9 injuries injury NNS cord-305956-l02xdq87 48 10 12 12 CD cord-305956-l02xdq87 48 11 , , , cord-305956-l02xdq87 48 12 14 14 CD cord-305956-l02xdq87 48 13 and and CC cord-305956-l02xdq87 48 14 the the DT cord-305956-l02xdq87 48 15 control control NN cord-305956-l02xdq87 48 16 of of IN cord-305956-l02xdq87 48 17 cytokine cytokine JJ cord-305956-l02xdq87 48 18 dysregulation dysregulation NN cord-305956-l02xdq87 48 19 at at IN cord-305956-l02xdq87 48 20 an an DT cord-305956-l02xdq87 48 21 early early JJ cord-305956-l02xdq87 48 22 stage stage NN cord-305956-l02xdq87 48 23 could could MD cord-305956-l02xdq87 48 24 be be VB cord-305956-l02xdq87 48 25 beneficial beneficial JJ cord-305956-l02xdq87 48 26 to to TO cord-305956-l02xdq87 48 27 curb curb VB cord-305956-l02xdq87 48 28 the the DT cord-305956-l02xdq87 48 29 disease disease NN cord-305956-l02xdq87 48 30 progression progression NN cord-305956-l02xdq87 48 31 . . . cord-305956-l02xdq87 49 1 15 15 CD cord-305956-l02xdq87 49 2 Hepatic hepatic JJ cord-305956-l02xdq87 49 3 inflammation inflammation NN cord-305956-l02xdq87 49 4 involving involve VBG cord-305956-l02xdq87 49 5 activation activation NN cord-305956-l02xdq87 49 6 of of IN cord-305956-l02xdq87 49 7 innate innate JJ cord-305956-l02xdq87 49 8 immune immune JJ cord-305956-l02xdq87 49 9 cells cell NNS cord-305956-l02xdq87 49 10 and and CC cord-305956-l02xdq87 49 11 the the DT cord-305956-l02xdq87 49 12 release release NN cord-305956-l02xdq87 49 13 of of IN cord-305956-l02xdq87 49 14 cytokines cytokine NNS cord-305956-l02xdq87 49 15 is be VBZ cord-305956-l02xdq87 49 16 a a DT cord-305956-l02xdq87 49 17 well well RB cord-305956-l02xdq87 49 18 - - HYPH cord-305956-l02xdq87 49 19 established establish VBN cord-305956-l02xdq87 49 20 driver driver NN cord-305956-l02xdq87 49 21 of of IN cord-305956-l02xdq87 49 22 liver liver NN cord-305956-l02xdq87 49 23 injury injury NN cord-305956-l02xdq87 49 24 from from IN cord-305956-l02xdq87 49 25 various various JJ cord-305956-l02xdq87 49 26 causes cause NNS cord-305956-l02xdq87 49 27 . . . cord-305956-l02xdq87 50 1 16 16 CD cord-305956-l02xdq87 51 1 In in IN cord-305956-l02xdq87 51 2 some some DT cord-305956-l02xdq87 51 3 of of IN cord-305956-l02xdq87 51 4 the the DT cord-305956-l02xdq87 51 5 available available JJ cord-305956-l02xdq87 51 6 case case NN cord-305956-l02xdq87 51 7 series series NN cord-305956-l02xdq87 51 8 of of IN cord-305956-l02xdq87 51 9 COVID-19 COVID-19 NNP cord-305956-l02xdq87 51 10 , , , cord-305956-l02xdq87 51 11 a a DT cord-305956-l02xdq87 51 12 correlation correlation NN cord-305956-l02xdq87 51 13 between between IN cord-305956-l02xdq87 51 14 lymphopenia lymphopenia NNP cord-305956-l02xdq87 51 15 and and CC cord-305956-l02xdq87 51 16 liver liver NN cord-305956-l02xdq87 51 17 injury injury NN cord-305956-l02xdq87 51 18 was be VBD cord-305956-l02xdq87 51 19 observed observe VBN cord-305956-l02xdq87 51 20 and and CC cord-305956-l02xdq87 51 21 CRP CRP NNP cord-305956-l02xdq87 51 22 ! ! . cord-305956-l02xdq87 52 1 20 20 CD cord-305956-l02xdq87 52 2 mg mg NNP cord-305956-l02xdq87 52 3 / / SYM cord-305956-l02xdq87 52 4 L L NNP cord-305956-l02xdq87 52 5 and and CC cord-305956-l02xdq87 52 6 a a DT cord-305956-l02xdq87 52 7 lymphocyte lymphocyte NN cord-305956-l02xdq87 52 8 count count NN cord-305956-l02xdq87 53 1 < < XX cord-305956-l02xdq87 53 2 1.1 1.1 CD cord-305956-l02xdq87 53 3 Â â CD cord-305956-l02xdq87 53 4 10 10 CD cord-305956-l02xdq87 53 5 9 9 CD cord-305956-l02xdq87 53 6 /L /L , cord-305956-l02xdq87 53 7 were be VBD cord-305956-l02xdq87 53 8 independent independent JJ cord-305956-l02xdq87 53 9 risk risk NN cord-305956-l02xdq87 53 10 factors factor NNS cord-305956-l02xdq87 53 11 for for IN cord-305956-l02xdq87 53 12 liver liver NN cord-305956-l02xdq87 53 13 injury injury NN cord-305956-l02xdq87 53 14 . . . cord-305956-l02xdq87 54 1 Notably notably RB cord-305956-l02xdq87 54 2 , , , cord-305956-l02xdq87 54 3 lymphopenia lymphopenia NNP cord-305956-l02xdq87 54 4 in in IN cord-305956-l02xdq87 55 1 COVID-19 COVID-19 NNP cord-305956-l02xdq87 55 2 studies study NNS cord-305956-l02xdq87 55 3 was be VBD cord-305956-l02xdq87 55 4 reportedly reportedly RB cord-305956-l02xdq87 55 5 observed observe VBN cord-305956-l02xdq87 55 6 in in IN cord-305956-l02xdq87 55 7 63 63 CD cord-305956-l02xdq87 55 8 % % NN cord-305956-l02xdq87 55 9 to to IN cord-305956-l02xdq87 55 10 70.3 70.3 CD cord-305956-l02xdq87 55 11 % % NN cord-305956-l02xdq87 55 12 of of IN cord-305956-l02xdq87 55 13 patients patient NNS cord-305956-l02xdq87 55 14 and and CC cord-305956-l02xdq87 55 15 those those DT cord-305956-l02xdq87 55 16 with with IN cord-305956-l02xdq87 55 17 lower low JJR cord-305956-l02xdq87 55 18 lymphocyte lymphocyte NN cord-305956-l02xdq87 55 19 counts count VBZ cord-305956-l02xdq87 55 20 more more RBR cord-305956-l02xdq87 55 21 susceptible susceptible JJ cord-305956-l02xdq87 55 22 to to IN cord-305956-l02xdq87 55 23 fatal fatal JJ cord-305956-l02xdq87 55 24 outcomes outcome NNS cord-305956-l02xdq87 55 25 . . . cord-305956-l02xdq87 56 1 11 11 CD cord-305956-l02xdq87 56 2 More More JJR cord-305956-l02xdq87 56 3 than than IN cord-305956-l02xdq87 56 4 20 20 CD cord-305956-l02xdq87 56 5 publications publication NNS cord-305956-l02xdq87 56 6 to to IN cord-305956-l02xdq87 56 7 date date NN cord-305956-l02xdq87 56 8 reported report VBD cord-305956-l02xdq87 56 9 abnormal abnormal JJ cord-305956-l02xdq87 56 10 levels level NNS cord-305956-l02xdq87 56 11 of of IN cord-305956-l02xdq87 56 12 aminotransferases aminotransferase NNS cord-305956-l02xdq87 56 13 in in IN cord-305956-l02xdq87 56 14 patients patient NNS cord-305956-l02xdq87 56 15 with with IN cord-305956-l02xdq87 56 16 COVID-19 COVID-19 NNP cord-305956-l02xdq87 56 17 . . . cord-305956-l02xdq87 57 1 [ [ -LRB- cord-305956-l02xdq87 57 2 7 7 CD cord-305956-l02xdq87 57 3 ] ] -RRB- cord-305956-l02xdq87 57 4 [ [ -LRB- cord-305956-l02xdq87 57 5 8 8 CD cord-305956-l02xdq87 57 6 ] ] -RRB- cord-305956-l02xdq87 57 7 [ [ -LRB- cord-305956-l02xdq87 57 8 9 9 CD cord-305956-l02xdq87 57 9 ] ] -RRB- cord-305956-l02xdq87 58 1 [ [ -LRB- cord-305956-l02xdq87 58 2 11 11 CD cord-305956-l02xdq87 58 3 ] ] -RRB- cord-305956-l02xdq87 58 4 [ [ -LRB- cord-305956-l02xdq87 58 5 12 12 CD cord-305956-l02xdq87 58 6 ] ] -RRB- cord-305956-l02xdq87 58 7 [ [ -LRB- cord-305956-l02xdq87 58 8 13 13 CD cord-305956-l02xdq87 58 9 ] ] -RRB- cord-305956-l02xdq87 59 1 [ [ -LRB- cord-305956-l02xdq87 59 2 17 17 CD cord-305956-l02xdq87 59 3 ] ] -RRB- cord-305956-l02xdq87 59 4 [ [ -LRB- cord-305956-l02xdq87 59 5 18 18 CD cord-305956-l02xdq87 59 6 ] ] -RRB- cord-305956-l02xdq87 59 7 [ [ -LRB- cord-305956-l02xdq87 59 8 19 19 CD cord-305956-l02xdq87 59 9 ] ] -RRB- cord-305956-l02xdq87 59 10 21 21 CD cord-305956-l02xdq87 59 11 , , , cord-305956-l02xdq87 59 12 [ [ -LRB- cord-305956-l02xdq87 59 13 23 23 CD cord-305956-l02xdq87 59 14 ] ] -RRB- cord-305956-l02xdq87 60 1 [ [ -LRB- cord-305956-l02xdq87 60 2 24 24 CD cord-305956-l02xdq87 60 3 ] ] -RRB- cord-305956-l02xdq87 60 4 [ [ -LRB- cord-305956-l02xdq87 60 5 25 25 CD cord-305956-l02xdq87 60 6 ] ] -RRB- cord-305956-l02xdq87 60 7 [ [ -LRB- cord-305956-l02xdq87 60 8 26 26 CD cord-305956-l02xdq87 60 9 ] ] -RRB- cord-305956-l02xdq87 60 10 [ [ -LRB- cord-305956-l02xdq87 60 11 27 27 CD cord-305956-l02xdq87 60 12 ] ] -RRB- cord-305956-l02xdq87 60 13 [ [ -LRB- cord-305956-l02xdq87 60 14 29 29 CD cord-305956-l02xdq87 60 15 ] ] -RRB- cord-305956-l02xdq87 61 1 [ [ -LRB- cord-305956-l02xdq87 61 2 30 30 CD cord-305956-l02xdq87 61 3 ] ] -RRB- cord-305956-l02xdq87 61 4 [ [ -LRB- cord-305956-l02xdq87 61 5 31 31 CD cord-305956-l02xdq87 61 6 ] ] -RRB- cord-305956-l02xdq87 62 1 [ [ -LRB- cord-305956-l02xdq87 62 2 32 32 CD cord-305956-l02xdq87 62 3 ] ] -RRB- cord-305956-l02xdq87 62 4 [ [ -LRB- cord-305956-l02xdq87 62 5 33 33 CD cord-305956-l02xdq87 62 6 ] ] -RRB- cord-305956-l02xdq87 62 7 35 35 CD cord-305956-l02xdq87 62 8 , , , cord-305956-l02xdq87 62 9 36 36 CD cord-305956-l02xdq87 63 1 A a DT cord-305956-l02xdq87 63 2 recent recent JJ cord-305956-l02xdq87 63 3 systematic systematic JJ cord-305956-l02xdq87 63 4 review review NN cord-305956-l02xdq87 63 5 and and CC cord-305956-l02xdq87 63 6 meta meta NNP cord-305956-l02xdq87 63 7 - - HYPH cord-305956-l02xdq87 63 8 analysis analysis NN cord-305956-l02xdq87 63 9 on on IN cord-305956-l02xdq87 63 10 LFT LFT NNP cord-305956-l02xdq87 63 11 abnormalities abnormality NNS cord-305956-l02xdq87 63 12 provided provide VBD cord-305956-l02xdq87 63 13 a a DT cord-305956-l02xdq87 63 14 pooled pool VBN cord-305956-l02xdq87 63 15 elevation elevation NN cord-305956-l02xdq87 63 16 of of IN cord-305956-l02xdq87 63 17 aspartate aspartate NN cord-305956-l02xdq87 63 18 aminotransferase aminotransferase NN cord-305956-l02xdq87 63 19 ( ( -LRB- cord-305956-l02xdq87 63 20 AST AST NNP cord-305956-l02xdq87 63 21 ) ) -RRB- cord-305956-l02xdq87 63 22 in in IN cord-305956-l02xdq87 63 23 33.3 33.3 CD cord-305956-l02xdq87 63 24 % % NN cord-305956-l02xdq87 63 25 and and CC cord-305956-l02xdq87 63 26 alanine alanine NN cord-305956-l02xdq87 63 27 aminotransferase aminotransferase NN cord-305956-l02xdq87 63 28 ( ( -LRB- cord-305956-l02xdq87 63 29 ALT ALT NNP cord-305956-l02xdq87 63 30 ) ) -RRB- cord-305956-l02xdq87 63 31 in in IN cord-305956-l02xdq87 63 32 24.1 24.1 CD cord-305956-l02xdq87 63 33 % % NN cord-305956-l02xdq87 63 34 of of IN cord-305956-l02xdq87 63 35 cases case NNS cord-305956-l02xdq87 63 36 . . . cord-305956-l02xdq87 64 1 39 39 CD cord-305956-l02xdq87 64 2 Various various JJ cord-305956-l02xdq87 64 3 investigators investigator NNS cord-305956-l02xdq87 64 4 across across IN cord-305956-l02xdq87 64 5 different different JJ cord-305956-l02xdq87 64 6 studies study NNS cord-305956-l02xdq87 64 7 reported report VBD cord-305956-l02xdq87 64 8 a a DT cord-305956-l02xdq87 64 9 correlation correlation NN cord-305956-l02xdq87 64 10 between between IN cord-305956-l02xdq87 64 11 the the DT cord-305956-l02xdq87 64 12 severity severity NN cord-305956-l02xdq87 64 13 of of IN cord-305956-l02xdq87 64 14 COVID-19 COVID-19 NNP cord-305956-l02xdq87 64 15 and and CC cord-305956-l02xdq87 64 16 the the DT cord-305956-l02xdq87 64 17 degree degree NN cord-305956-l02xdq87 64 18 of of IN cord-305956-l02xdq87 64 19 liver liver NN cord-305956-l02xdq87 64 20 dysfunction dysfunction NN cord-305956-l02xdq87 64 21 . . . cord-305956-l02xdq87 65 1 8 8 CD cord-305956-l02xdq87 65 2 , , , cord-305956-l02xdq87 65 3 11 11 CD cord-305956-l02xdq87 65 4 , , , cord-305956-l02xdq87 65 5 25 25 CD cord-305956-l02xdq87 65 6 In in IN cord-305956-l02xdq87 65 7 one one CD cord-305956-l02xdq87 65 8 retrospective retrospective JJ cord-305956-l02xdq87 65 9 study study NN cord-305956-l02xdq87 65 10 , , , cord-305956-l02xdq87 65 11 one one CD cord-305956-l02xdq87 65 12 patient patient NN cord-305956-l02xdq87 65 13 experienced experience VBD cord-305956-l02xdq87 65 14 severe severe JJ cord-305956-l02xdq87 65 15 hepatitis hepatitis NN cord-305956-l02xdq87 65 16 with with IN cord-305956-l02xdq87 65 17 ALT ALT NNP cord-305956-l02xdq87 65 18 of of IN cord-305956-l02xdq87 65 19 7 7 CD cord-305956-l02xdq87 66 1 On on IN cord-305956-l02xdq87 66 2 the the DT cord-305956-l02xdq87 66 3 other other JJ cord-305956-l02xdq87 66 4 hand hand NN cord-305956-l02xdq87 66 5 , , , cord-305956-l02xdq87 66 6 mild mild JJ cord-305956-l02xdq87 66 7 and and CC cord-305956-l02xdq87 66 8 moderate moderate JJ cord-305956-l02xdq87 66 9 cases case NNS cord-305956-l02xdq87 66 10 experienced experience VBD cord-305956-l02xdq87 66 11 only only RB cord-305956-l02xdq87 66 12 discrete discrete JJ cord-305956-l02xdq87 66 13 abnormal abnormal JJ cord-305956-l02xdq87 66 14 LFT LFT NNP cord-305956-l02xdq87 66 15 values value NNS cord-305956-l02xdq87 66 16 . . . cord-305956-l02xdq87 67 1 These these DT cord-305956-l02xdq87 67 2 reports report NNS cord-305956-l02xdq87 67 3 support support VBP cord-305956-l02xdq87 67 4 the the DT cord-305956-l02xdq87 67 5 concept concept NN cord-305956-l02xdq87 67 6 that that IN cord-305956-l02xdq87 67 7 the the DT cord-305956-l02xdq87 67 8 disease disease NN cord-305956-l02xdq87 67 9 severity severity NN cord-305956-l02xdq87 67 10 and and CC cord-305956-l02xdq87 67 11 an an DT cord-305956-l02xdq87 67 12 older old JJR cord-305956-l02xdq87 67 13 age age NN cord-305956-l02xdq87 67 14 predispose predispose VBP cord-305956-l02xdq87 67 15 to to IN cord-305956-l02xdq87 67 16 more more RBR cord-305956-l02xdq87 67 17 severe severe JJ cord-305956-l02xdq87 67 18 liver liver NN cord-305956-l02xdq87 67 19 injury injury NN cord-305956-l02xdq87 67 20 from from IN cord-305956-l02xdq87 67 21 COVID-19 COVID-19 NNP cord-305956-l02xdq87 67 22 . . . cord-305956-l02xdq87 68 1 Based base VBN cord-305956-l02xdq87 68 2 on on IN cord-305956-l02xdq87 68 3 these these DT cord-305956-l02xdq87 68 4 case case NN cord-305956-l02xdq87 68 5 series series NN cord-305956-l02xdq87 68 6 , , , cord-305956-l02xdq87 68 7 patients patient NNS cord-305956-l02xdq87 68 8 with with IN cord-305956-l02xdq87 68 9 severe severe JJ cord-305956-l02xdq87 68 10 COVID-19 covid-19 JJ cord-305956-l02xdq87 68 11 and and CC cord-305956-l02xdq87 68 12 pre pre JJ cord-305956-l02xdq87 68 13 - - JJ cord-305956-l02xdq87 68 14 existing existing JJ cord-305956-l02xdq87 68 15 liver liver NN cord-305956-l02xdq87 68 16 conditions condition NNS cord-305956-l02xdq87 68 17 8but 8but CD cord-305956-l02xdq87 68 18 also also RB cord-305956-l02xdq87 68 19 elderly elderly JJ cord-305956-l02xdq87 68 20 patients patient NNS cord-305956-l02xdq87 68 21 11 11 CD cord-305956-l02xdq87 68 22 -should -should MD cord-305956-l02xdq87 68 23 undergo undergo VB cord-305956-l02xdq87 68 24 surveillance surveillance NN cord-305956-l02xdq87 68 25 and and CC cord-305956-l02xdq87 68 26 individually individually RB cord-305956-l02xdq87 68 27 tailored tailor VBN cord-305956-l02xdq87 68 28 therapeutic therapeutic JJ cord-305956-l02xdq87 68 29 approaches approach NNS cord-305956-l02xdq87 68 30 for for IN cord-305956-l02xdq87 68 31 potential potential JJ cord-305956-l02xdq87 68 32 liver liver NN cord-305956-l02xdq87 68 33 injury injury NN cord-305956-l02xdq87 68 34 . . . cord-305956-l02xdq87 69 1 A a DT cord-305956-l02xdq87 69 2 recently recently RB cord-305956-l02xdq87 69 3 published publish VBN cord-305956-l02xdq87 69 4 article article NN cord-305956-l02xdq87 69 5 by by IN cord-305956-l02xdq87 69 6 Bangash Bangash NNP cord-305956-l02xdq87 69 7 et et NNP cord-305956-l02xdq87 69 8 al al NNP cord-305956-l02xdq87 69 9 . . . cord-305956-l02xdq87 70 1 argues argue VBZ cord-305956-l02xdq87 70 2 after after IN cord-305956-l02xdq87 70 3 careful careful JJ cord-305956-l02xdq87 70 4 review review NN cord-305956-l02xdq87 70 5 of of IN cord-305956-l02xdq87 70 6 seven seven CD cord-305956-l02xdq87 70 7 relevant relevant JJ cord-305956-l02xdq87 70 8 studies study NNS cord-305956-l02xdq87 70 9 that that WDT cord-305956-l02xdq87 70 10 elevated elevate VBD cord-305956-l02xdq87 70 11 ALT alt NN cord-305956-l02xdq87 70 12 and and CC cord-305956-l02xdq87 70 13 AST AST NNP cord-305956-l02xdq87 70 14 may may MD cord-305956-l02xdq87 70 15 not not RB cord-305956-l02xdq87 70 16 necessarily necessarily RB cord-305956-l02xdq87 70 17 be be VB cord-305956-l02xdq87 70 18 of of IN cord-305956-l02xdq87 70 19 hepatic hepatic JJ cord-305956-l02xdq87 70 20 origin origin NN cord-305956-l02xdq87 70 21 alone alone RB cord-305956-l02xdq87 70 22 . . . cord-305956-l02xdq87 71 1 The the DT cord-305956-l02xdq87 71 2 authors author NNS cord-305956-l02xdq87 71 3 have have VBP cord-305956-l02xdq87 71 4 given give VBN cord-305956-l02xdq87 71 5 a a DT cord-305956-l02xdq87 71 6 timely timely JJ cord-305956-l02xdq87 71 7 reminder reminder NN cord-305956-l02xdq87 71 8 that that IN cord-305956-l02xdq87 71 9 it -PRON- PRP cord-305956-l02xdq87 71 10 is be VBZ cord-305956-l02xdq87 71 11 common common JJ cord-305956-l02xdq87 71 12 for for IN cord-305956-l02xdq87 71 13 other other JJ cord-305956-l02xdq87 71 14 respiratory respiratory JJ cord-305956-l02xdq87 71 15 viruses virus NNS cord-305956-l02xdq87 71 16 to to TO cord-305956-l02xdq87 71 17 create create VB cord-305956-l02xdq87 71 18 similar similar JJ cord-305956-l02xdq87 71 19 LFT LFT NNP cord-305956-l02xdq87 71 20 elevations elevation NNS cord-305956-l02xdq87 71 21 28 28 CD cord-305956-l02xdq87 71 22 and and CC cord-305956-l02xdq87 71 23 thus thus RB cord-305956-l02xdq87 71 24 more more RBR cord-305956-l02xdq87 71 25 prospective prospective JJ cord-305956-l02xdq87 71 26 data datum NNS cord-305956-l02xdq87 71 27 related relate VBN cord-305956-l02xdq87 71 28 to to IN cord-305956-l02xdq87 71 29 the the DT cord-305956-l02xdq87 71 30 clinical clinical JJ cord-305956-l02xdq87 71 31 relevance relevance NN cord-305956-l02xdq87 71 32 COVID-19 COVID-19 NNP cord-305956-l02xdq87 71 33 and and CC cord-305956-l02xdq87 71 34 liver liver NN cord-305956-l02xdq87 71 35 injury injury NN cord-305956-l02xdq87 71 36 is be VBZ cord-305956-l02xdq87 71 37 required require VBN cord-305956-l02xdq87 71 38 . . . cord-305956-l02xdq87 72 1 The the DT cord-305956-l02xdq87 72 2 previous previous JJ cord-305956-l02xdq87 72 3 pathogenic pathogenic JJ cord-305956-l02xdq87 72 4 coronaviruses coronaviruse NNS cord-305956-l02xdq87 72 5 , , , cord-305956-l02xdq87 72 6 such such JJ cord-305956-l02xdq87 72 7 as as IN cord-305956-l02xdq87 72 8 SARS SARS NNP cord-305956-l02xdq87 72 9 - - HYPH cord-305956-l02xdq87 72 10 CoV CoV NNP cord-305956-l02xdq87 72 11 and and CC cord-305956-l02xdq87 72 12 the the DT cord-305956-l02xdq87 72 13 Middle Middle NNP cord-305956-l02xdq87 72 14 East East NNP cord-305956-l02xdq87 72 15 respiratory respiratory JJ cord-305956-l02xdq87 72 16 syndrome syndrome NN cord-305956-l02xdq87 72 17 coronavirus coronavirus NN cord-305956-l02xdq87 72 18 ( ( -LRB- cord-305956-l02xdq87 72 19 MERS MERS NNP cord-305956-l02xdq87 72 20 - - HYPH cord-305956-l02xdq87 72 21 CoV CoV NNP cord-305956-l02xdq87 72 22 ) ) -RRB- cord-305956-l02xdq87 72 23 , , , cord-305956-l02xdq87 72 24 were be VBD cord-305956-l02xdq87 72 25 also also RB cord-305956-l02xdq87 72 26 reported report VBN cord-305956-l02xdq87 72 27 to to TO cord-305956-l02xdq87 72 28 manifest manifest VB cord-305956-l02xdq87 72 29 with with IN cord-305956-l02xdq87 72 30 elevated elevated JJ cord-305956-l02xdq87 72 31 levels level NNS cord-305956-l02xdq87 72 32 of of IN cord-305956-l02xdq87 72 33 ALT ALT NNP cord-305956-l02xdq87 72 34 and and CC cord-305956-l02xdq87 72 35 AST AST NNP cord-305956-l02xdq87 72 36 . . . cord-305956-l02xdq87 73 1 39 39 CD cord-305956-l02xdq87 73 2 More More JJR cord-305956-l02xdq87 73 3 generally generally RB cord-305956-l02xdq87 73 4 , , , cord-305956-l02xdq87 73 5 non non JJ cord-305956-l02xdq87 73 6 - - JJ cord-305956-l02xdq87 73 7 hepatotropic hepatotropic JJ cord-305956-l02xdq87 73 8 viral viral JJ cord-305956-l02xdq87 73 9 infections infection NNS cord-305956-l02xdq87 73 10 may may MD cord-305956-l02xdq87 73 11 affect affect VB cord-305956-l02xdq87 73 12 the the DT cord-305956-l02xdq87 73 13 liver liver NN cord-305956-l02xdq87 73 14 and and CC cord-305956-l02xdq87 73 15 induce induce VB cord-305956-l02xdq87 73 16 hepatitis hepatitis NN cord-305956-l02xdq87 73 17 or or CC cord-305956-l02xdq87 73 18 fulminant fulminant JJ cord-305956-l02xdq87 73 19 acute acute JJ cord-305956-l02xdq87 73 20 liver liver NN cord-305956-l02xdq87 73 21 failure failure NN cord-305956-l02xdq87 73 22 . . . cord-305956-l02xdq87 74 1 However however RB cord-305956-l02xdq87 74 2 , , , cord-305956-l02xdq87 74 3 in in IN cord-305956-l02xdq87 74 4 the the DT cord-305956-l02xdq87 74 5 majority majority NN cord-305956-l02xdq87 74 6 of of IN cord-305956-l02xdq87 74 7 cases case NNS cord-305956-l02xdq87 74 8 , , , cord-305956-l02xdq87 74 9 recovery recovery NN cord-305956-l02xdq87 74 10 from from IN cord-305956-l02xdq87 74 11 viral viral JJ cord-305956-l02xdq87 74 12 illness illness NN cord-305956-l02xdq87 74 13 is be VBZ cord-305956-l02xdq87 74 14 often often RB cord-305956-l02xdq87 74 15 sufficient sufficient JJ cord-305956-l02xdq87 74 16 to to TO cord-305956-l02xdq87 74 17 resolve resolve VB cord-305956-l02xdq87 74 18 liver liver NN cord-305956-l02xdq87 74 19 injury injury NN cord-305956-l02xdq87 74 20 . . . cord-305956-l02xdq87 75 1 40 40 CD cord-305956-l02xdq87 76 1 Like like IN cord-305956-l02xdq87 76 2 in in IN cord-305956-l02xdq87 76 3 SARS SARS NNP cord-305956-l02xdq87 76 4 - - HYPH cord-305956-l02xdq87 76 5 CoV CoV NNP cord-305956-l02xdq87 76 6 and and CC cord-305956-l02xdq87 76 7 MERS MERS NNP cord-305956-l02xdq87 76 8 - - HYPH cord-305956-l02xdq87 76 9 CoV cov NN cord-305956-l02xdq87 76 10 infections infection NNS cord-305956-l02xdq87 76 11 , , , cord-305956-l02xdq87 76 12 abnormal abnormal JJ cord-305956-l02xdq87 76 13 levels level NNS cord-305956-l02xdq87 76 14 of of IN cord-305956-l02xdq87 76 15 albumin albumin NN cord-305956-l02xdq87 76 16 and and CC cord-305956-l02xdq87 76 17 lactate lactate NN cord-305956-l02xdq87 76 18 dehydrogenase dehydrogenase NN cord-305956-l02xdq87 76 19 ( ( -LRB- cord-305956-l02xdq87 76 20 LDH LDH NNP cord-305956-l02xdq87 76 21 ) ) -RRB- cord-305956-l02xdq87 76 22 were be VBD cord-305956-l02xdq87 76 23 also also RB cord-305956-l02xdq87 76 24 reported report VBN cord-305956-l02xdq87 76 25 in in IN cord-305956-l02xdq87 76 26 SARS SARS NNP cord-305956-l02xdq87 76 27 - - HYPH cord-305956-l02xdq87 76 28 CoV-2 CoV-2 NNP cord-305956-l02xdq87 76 29 infection infection NN cord-305956-l02xdq87 76 30 , , , cord-305956-l02xdq87 76 31 with with IN cord-305956-l02xdq87 76 32 the the DT cord-305956-l02xdq87 76 33 maximum maximum NN cord-305956-l02xdq87 76 34 of of IN cord-305956-l02xdq87 76 35 98 98 CD cord-305956-l02xdq87 76 36 % % NN cord-305956-l02xdq87 76 37 and and CC cord-305956-l02xdq87 76 38 76 76 CD cord-305956-l02xdq87 76 39 % % NN cord-305956-l02xdq87 76 40 of of IN cord-305956-l02xdq87 76 41 the the DT cord-305956-l02xdq87 76 42 patients patient NNS cord-305956-l02xdq87 76 43 affected affect VBN cord-305956-l02xdq87 76 44 as as IN cord-305956-l02xdq87 76 45 reported report VBN cord-305956-l02xdq87 76 46 in in IN cord-305956-l02xdq87 76 47 the the DT cord-305956-l02xdq87 76 48 study study NN cord-305956-l02xdq87 76 49 by by IN cord-305956-l02xdq87 76 50 Chen Chen NNP cord-305956-l02xdq87 76 51 et et NNP cord-305956-l02xdq87 76 52 al al NNP cord-305956-l02xdq87 76 53 . . . cord-305956-l02xdq87 77 1 17 17 CD cord-305956-l02xdq87 78 1 It -PRON- PRP cord-305956-l02xdq87 78 2 is be VBZ cord-305956-l02xdq87 78 3 important important JJ cord-305956-l02xdq87 78 4 to to TO cord-305956-l02xdq87 78 5 remember remember VB cord-305956-l02xdq87 78 6 that that IN cord-305956-l02xdq87 78 7 LDH LDH NNP cord-305956-l02xdq87 78 8 and and CC cord-305956-l02xdq87 78 9 AST AST NNP cord-305956-l02xdq87 78 10 elevation elevation NN cord-305956-l02xdq87 78 11 could could MD cord-305956-l02xdq87 78 12 be be VB cord-305956-l02xdq87 78 13 from from IN cord-305956-l02xdq87 78 14 muscle muscle NN cord-305956-l02xdq87 78 15 damage damage NN cord-305956-l02xdq87 78 16 and and CC cord-305956-l02xdq87 78 17 not not RB cord-305956-l02xdq87 78 18 necessarily necessarily RB cord-305956-l02xdq87 78 19 reflect reflect VBP cord-305956-l02xdq87 78 20 liver liver NN cord-305956-l02xdq87 78 21 injury injury NN cord-305956-l02xdq87 78 22 . . . cord-305956-l02xdq87 79 1 The the DT cord-305956-l02xdq87 79 2 current current JJ cord-305956-l02xdq87 79 3 armory armory NN cord-305956-l02xdq87 79 4 of of IN cord-305956-l02xdq87 79 5 therapeutic therapeutic JJ cord-305956-l02xdq87 79 6 agents agent NNS cord-305956-l02xdq87 79 7 explored explore VBN cord-305956-l02xdq87 79 8 against against IN cord-305956-l02xdq87 79 9 SARS SARS NNP cord-305956-l02xdq87 79 10 - - HYPH cord-305956-l02xdq87 79 11 CoV-2 CoV-2 NNP cord-305956-l02xdq87 79 12 includes include VBZ cord-305956-l02xdq87 79 13 several several JJ cord-305956-l02xdq87 79 14 antiviral antiviral JJ cord-305956-l02xdq87 79 15 agents agent NNS cord-305956-l02xdq87 79 16 , , , cord-305956-l02xdq87 79 17 supportive supportive JJ cord-305956-l02xdq87 79 18 therapy therapy NN cord-305956-l02xdq87 79 19 and and CC cord-305956-l02xdq87 79 20 trials trial NNS cord-305956-l02xdq87 79 21 of of IN cord-305956-l02xdq87 79 22 alternative alternative JJ cord-305956-l02xdq87 79 23 medicines medicine NNS cord-305956-l02xdq87 79 24 in in IN cord-305956-l02xdq87 79 25 many many JJ cord-305956-l02xdq87 79 26 regions region NNS cord-305956-l02xdq87 79 27 of of IN cord-305956-l02xdq87 79 28 the the DT cord-305956-l02xdq87 79 29 world world NN cord-305956-l02xdq87 79 30 . . . cord-305956-l02xdq87 80 1 Given give VBN cord-305956-l02xdq87 80 2 the the DT cord-305956-l02xdq87 80 3 fact fact NN cord-305956-l02xdq87 80 4 that that IN cord-305956-l02xdq87 80 5 the the DT cord-305956-l02xdq87 80 6 liver liver NN cord-305956-l02xdq87 80 7 is be VBZ cord-305956-l02xdq87 80 8 involved involve VBN cord-305956-l02xdq87 80 9 in in IN cord-305956-l02xdq87 80 10 the the DT cord-305956-l02xdq87 80 11 metabolism metabolism NN cord-305956-l02xdq87 80 12 of of IN cord-305956-l02xdq87 80 13 many many JJ cord-305956-l02xdq87 80 14 drugs drug NNS cord-305956-l02xdq87 80 15 , , , cord-305956-l02xdq87 80 16 including include VBG cord-305956-l02xdq87 80 17 nucleoside nucleoside JJ cord-305956-l02xdq87 80 18 analogs analog NNS cord-305956-l02xdq87 80 19 and and CC cord-305956-l02xdq87 80 20 protease protease NN cord-305956-l02xdq87 80 21 inhibitors inhibitor NNS cord-305956-l02xdq87 80 22 that that WDT cord-305956-l02xdq87 80 23 are be VBP cord-305956-l02xdq87 80 24 currently currently RB cord-305956-l02xdq87 80 25 used use VBN cord-305956-l02xdq87 80 26 to to TO cord-305956-l02xdq87 80 27 treat treat VB cord-305956-l02xdq87 80 28 COVID-19 COVID-19 NNP cord-305956-l02xdq87 80 29 , , , cord-305956-l02xdq87 80 30 hepatotoxicity hepatotoxicity NN cord-305956-l02xdq87 80 31 from from IN cord-305956-l02xdq87 80 32 these these DT cord-305956-l02xdq87 80 33 drugs drug NNS cord-305956-l02xdq87 80 34 can can MD cord-305956-l02xdq87 80 35 arise arise VB cord-305956-l02xdq87 80 36 . . . cord-305956-l02xdq87 81 1 A a DT cord-305956-l02xdq87 81 2 recent recent JJ cord-305956-l02xdq87 81 3 randomized randomize VBN cord-305956-l02xdq87 81 4 controlled control VBN cord-305956-l02xdq87 81 5 trial trial NN cord-305956-l02xdq87 81 6 of of IN cord-305956-l02xdq87 81 7 lopinavir lopinavir NNS cord-305956-l02xdq87 81 8 and and CC cord-305956-l02xdq87 81 9 ritonavir ritonavir NNP cord-305956-l02xdq87 81 10 in in IN cord-305956-l02xdq87 81 11 severe severe JJ cord-305956-l02xdq87 81 12 COVID-19 COVID-19 NNP cord-305956-l02xdq87 81 13 reported report VBD cord-305956-l02xdq87 81 14 that that IN cord-305956-l02xdq87 81 15 elevated elevated JJ cord-305956-l02xdq87 81 16 levels level NNS cord-305956-l02xdq87 81 17 of of IN cord-305956-l02xdq87 81 18 AST ast NN cord-305956-l02xdq87 81 19 , , , cord-305956-l02xdq87 81 20 ALT alt NN cord-305956-l02xdq87 81 21 and and CC cord-305956-l02xdq87 81 22 total total JJ cord-305956-l02xdq87 81 23 bilirubin bilirubin NN cord-305956-l02xdq87 81 24 occurred occur VBD cord-305956-l02xdq87 81 25 as as IN cord-305956-l02xdq87 81 26 adverse adverse JJ cord-305956-l02xdq87 81 27 effects effect NNS cord-305956-l02xdq87 81 28 in in IN cord-305956-l02xdq87 81 29 a a DT cord-305956-l02xdq87 81 30 few few JJ cord-305956-l02xdq87 81 31 patients patient NNS cord-305956-l02xdq87 81 32 . . . cord-305956-l02xdq87 82 1 41 41 CD cord-305956-l02xdq87 83 1 Another another DT cord-305956-l02xdq87 83 2 case case NN cord-305956-l02xdq87 83 3 series series NN cord-305956-l02xdq87 83 4 from from IN cord-305956-l02xdq87 83 5 Wuhan Wuhan NNP cord-305956-l02xdq87 83 6 reported report VBD cord-305956-l02xdq87 83 7 that that IN cord-305956-l02xdq87 83 8 55.4 55.4 CD cord-305956-l02xdq87 83 9 % % NN cord-305956-l02xdq87 83 10 of of IN cord-305956-l02xdq87 83 11 patients patient NNS cord-305956-l02xdq87 83 12 experienced experience VBD cord-305956-l02xdq87 83 13 liver liver NN cord-305956-l02xdq87 83 14 injuries injury NNS cord-305956-l02xdq87 83 15 after after IN cord-305956-l02xdq87 83 16 treatment treatment NN cord-305956-l02xdq87 83 17 with with IN cord-305956-l02xdq87 83 18 lopinavir lopinavir NNS cord-305956-l02xdq87 83 19 and and CC cord-305956-l02xdq87 83 20 ritonavir ritonavir NNP cord-305956-l02xdq87 83 21 . . . cord-305956-l02xdq87 84 1 26 26 CD cord-305956-l02xdq87 85 1 Fan Fan NNP cord-305956-l02xdq87 85 2 et et NNP cord-305956-l02xdq87 85 3 al al NNP cord-305956-l02xdq87 85 4 . . . cord-305956-l02xdq87 86 1 published publish VBD cord-305956-l02xdq87 86 2 a a DT cord-305956-l02xdq87 86 3 retrospective retrospective JJ cord-305956-l02xdq87 86 4 study study NN cord-305956-l02xdq87 86 5 on on IN cord-305956-l02xdq87 86 6 COVID-19 COVID-19 NNP cord-305956-l02xdq87 86 7 and and CC cord-305956-l02xdq87 86 8 observed observe VBD cord-305956-l02xdq87 86 9 that that IN cord-305956-l02xdq87 86 10 the the DT cord-305956-l02xdq87 86 11 utilization utilization NN cord-305956-l02xdq87 86 12 rate rate NN cord-305956-l02xdq87 86 13 of of IN cord-305956-l02xdq87 86 14 this this DT cord-305956-l02xdq87 86 15 drug drug NN cord-305956-l02xdq87 86 16 combination combination NN cord-305956-l02xdq87 86 17 was be VBD cord-305956-l02xdq87 86 18 significantly significantly RB cord-305956-l02xdq87 86 19 higher high JJR cord-305956-l02xdq87 86 20 in in IN cord-305956-l02xdq87 86 21 patients patient NNS cord-305956-l02xdq87 86 22 with with IN cord-305956-l02xdq87 86 23 abnormal abnormal JJ cord-305956-l02xdq87 86 24 LFTs lft NNS cord-305956-l02xdq87 86 25 compared compare VBN cord-305956-l02xdq87 86 26 with with IN cord-305956-l02xdq87 86 27 patients patient NNS cord-305956-l02xdq87 86 28 without without IN cord-305956-l02xdq87 86 29 LFT LFT NNP cord-305956-l02xdq87 86 30 elevations elevation NNS cord-305956-l02xdq87 86 31 ( ( -LRB- cord-305956-l02xdq87 86 32 56.1 56.1 CD cord-305956-l02xdq87 86 33 % % NN cord-305956-l02xdq87 86 34 vs. vs. IN cord-305956-l02xdq87 86 35 25 25 CD cord-305956-l02xdq87 86 36 % % NN cord-305956-l02xdq87 86 37 , , , cord-305956-l02xdq87 86 38 p p NN cord-305956-l02xdq87 86 39 ¼ ¼ CD cord-305956-l02xdq87 86 40 0.009 0.009 CD cord-305956-l02xdq87 86 41 ) ) -RRB- cord-305956-l02xdq87 86 42 . . . cord-305956-l02xdq87 87 1 In in IN cord-305956-l02xdq87 87 2 this this DT cord-305956-l02xdq87 87 3 study study NN cord-305956-l02xdq87 87 4 , , , cord-305956-l02xdq87 87 5 47.3 47.3 CD cord-305956-l02xdq87 87 6 % % NN cord-305956-l02xdq87 87 7 of of IN cord-305956-l02xdq87 87 8 the the DT cord-305956-l02xdq87 87 9 discharged discharge VBN cord-305956-l02xdq87 87 10 patients patient NNS cord-305956-l02xdq87 87 11 showed show VBD cord-305956-l02xdq87 87 12 elevated elevated JJ cord-305956-l02xdq87 87 13 LFTs lft NNS cord-305956-l02xdq87 87 14 at at IN cord-305956-l02xdq87 87 15 baseline baseline NN cord-305956-l02xdq87 87 16 , , , cord-305956-l02xdq87 87 17 and and CC cord-305956-l02xdq87 87 18 23.7 23.7 CD cord-305956-l02xdq87 87 19 % % NN cord-305956-l02xdq87 87 20 developed develop VBD cord-305956-l02xdq87 87 21 abnormalities abnormality NNS cord-305956-l02xdq87 87 22 during during IN cord-305956-l02xdq87 87 23 hospitalization hospitalization NN cord-305956-l02xdq87 87 24 , , , cord-305956-l02xdq87 87 25 suggesting suggest VBG cord-305956-l02xdq87 87 26 emerging emerge VBG cord-305956-l02xdq87 87 27 liver liver NN cord-305956-l02xdq87 87 28 injury injury NN cord-305956-l02xdq87 87 29 from from IN cord-305956-l02xdq87 87 30 drugs drug NNS cord-305956-l02xdq87 87 31 or or CC cord-305956-l02xdq87 87 32 during during IN cord-305956-l02xdq87 87 33 the the DT cord-305956-l02xdq87 87 34 course course NN cord-305956-l02xdq87 87 35 of of IN cord-305956-l02xdq87 87 36 the the DT cord-305956-l02xdq87 87 37 infection infection NN cord-305956-l02xdq87 87 38 . . . cord-305956-l02xdq87 88 1 Importantly importantly RB cord-305956-l02xdq87 88 2 , , , cord-305956-l02xdq87 88 3 LFT LFT NNP cord-305956-l02xdq87 88 4 elevation elevation NN cord-305956-l02xdq87 88 5 during during IN cord-305956-l02xdq87 88 6 the the DT cord-305956-l02xdq87 88 7 hospital hospital NN cord-305956-l02xdq87 88 8 stay stay NN cord-305956-l02xdq87 88 9 was be VBD cord-305956-l02xdq87 88 10 associated associate VBN cord-305956-l02xdq87 88 11 with with IN cord-305956-l02xdq87 88 12 prolonged prolonged JJ cord-305956-l02xdq87 88 13 length length NN cord-305956-l02xdq87 88 14 of of IN cord-305956-l02xdq87 88 15 hospitalization hospitalization NN cord-305956-l02xdq87 88 16 . . . cord-305956-l02xdq87 89 1 7 7 CD cord-305956-l02xdq87 89 2 Chloroquine Chloroquine NNP cord-305956-l02xdq87 89 3 , , , cord-305956-l02xdq87 89 4 an an DT cord-305956-l02xdq87 89 5 old old JJ cord-305956-l02xdq87 89 6 drug drug NN cord-305956-l02xdq87 89 7 with with IN cord-305956-l02xdq87 89 8 a a DT cord-305956-l02xdq87 89 9 potential potential NN cord-305956-l02xdq87 89 10 of of IN cord-305956-l02xdq87 89 11 repositioning reposition VBG cord-305956-l02xdq87 89 12 for for IN cord-305956-l02xdq87 89 13 new new JJ cord-305956-l02xdq87 89 14 treatment treatment NN cord-305956-l02xdq87 89 15 indications indication NNS cord-305956-l02xdq87 89 16 , , , cord-305956-l02xdq87 89 17 has have VBZ cord-305956-l02xdq87 89 18 recently recently RB cord-305956-l02xdq87 89 19 been be VBN cord-305956-l02xdq87 89 20 tried try VBN cord-305956-l02xdq87 89 21 in in IN cord-305956-l02xdq87 89 22 patients patient NNS cord-305956-l02xdq87 89 23 infected infect VBN cord-305956-l02xdq87 89 24 with with IN cord-305956-l02xdq87 89 25 SARS SARS NNP cord-305956-l02xdq87 89 26 - - HYPH cord-305956-l02xdq87 89 27 CoV-2 CoV-2 NNP cord-305956-l02xdq87 89 28 . . . cord-305956-l02xdq87 90 1 After after IN cord-305956-l02xdq87 90 2 a a DT cord-305956-l02xdq87 90 3 profound profound JJ cord-305956-l02xdq87 90 4 success success NN cord-305956-l02xdq87 90 5 in in IN cord-305956-l02xdq87 90 6 inhibiting inhibit VBG cord-305956-l02xdq87 90 7 viral viral JJ cord-305956-l02xdq87 90 8 replication replication NN cord-305956-l02xdq87 90 9 in in IN cord-305956-l02xdq87 90 10 vitro vitro FW cord-305956-l02xdq87 90 11 , , , cord-305956-l02xdq87 90 12 concurrent concurrent JJ cord-305956-l02xdq87 90 13 clinical clinical JJ cord-305956-l02xdq87 90 14 trials trial NNS cord-305956-l02xdq87 90 15 ( ( -LRB- cord-305956-l02xdq87 90 16 > > NFP cord-305956-l02xdq87 90 17 20 20 CD cord-305956-l02xdq87 90 18 ) ) -RRB- cord-305956-l02xdq87 90 19 on on IN cord-305956-l02xdq87 90 20 chloroquine chloroquine NN cord-305956-l02xdq87 90 21 conducted conduct VBN cord-305956-l02xdq87 90 22 at at IN cord-305956-l02xdq87 90 23 10 10 CD cord-305956-l02xdq87 90 24 hospitals hospital NNS cord-305956-l02xdq87 90 25 across across IN cord-305956-l02xdq87 90 26 China China NNP cord-305956-l02xdq87 90 27 have have VBP cord-305956-l02xdq87 90 28 demonstrated demonstrate VBN cord-305956-l02xdq87 90 29 superior superior JJ cord-305956-l02xdq87 90 30 efficacy efficacy NN cord-305956-l02xdq87 90 31 in in IN cord-305956-l02xdq87 90 32 viral viral JJ cord-305956-l02xdq87 90 33 control control NN cord-305956-l02xdq87 90 34 . . . cord-305956-l02xdq87 91 1 42 42 CD cord-305956-l02xdq87 92 1 The the DT cord-305956-l02xdq87 92 2 pharmacodynamic pharmacodynamic JJ cord-305956-l02xdq87 92 3 activity activity NN cord-305956-l02xdq87 92 4 of of IN cord-305956-l02xdq87 92 5 this this DT cord-305956-l02xdq87 92 6 drug drug NN cord-305956-l02xdq87 92 7 in in IN cord-305956-l02xdq87 92 8 COVID-19 COVID-19 NNP cord-305956-l02xdq87 92 9 may may MD cord-305956-l02xdq87 92 10 involve involve VB cord-305956-l02xdq87 92 11 the the DT cord-305956-l02xdq87 92 12 arresting arresting NN cord-305956-l02xdq87 92 13 of of IN cord-305956-l02xdq87 92 14 cytokine cytokine NN cord-305956-l02xdq87 92 15 storms storm NNS cord-305956-l02xdq87 92 16 or or CC cord-305956-l02xdq87 92 17 the the DT cord-305956-l02xdq87 92 18 activation activation NN cord-305956-l02xdq87 92 19 of of IN cord-305956-l02xdq87 92 20 CD8þ CD8þ NNP cord-305956-l02xdq87 92 21 cells cell NNS cord-305956-l02xdq87 92 22 or or CC cord-305956-l02xdq87 92 23 by by IN cord-305956-l02xdq87 92 24 preventing prevent VBG cord-305956-l02xdq87 92 25 endocytosismediated endocytosismediate VBN cord-305956-l02xdq87 92 26 uptake uptake NN cord-305956-l02xdq87 92 27 of of IN cord-305956-l02xdq87 92 28 the the DT cord-305956-l02xdq87 92 29 virus virus NN cord-305956-l02xdq87 92 30 . . . cord-305956-l02xdq87 93 1 43 43 CD cord-305956-l02xdq87 94 1 Importantly importantly RB cord-305956-l02xdq87 94 2 , , , cord-305956-l02xdq87 94 3 hepatotoxicity hepatotoxicity NN cord-305956-l02xdq87 94 4 related relate VBN cord-305956-l02xdq87 94 5 to to IN cord-305956-l02xdq87 94 6 chloroquine chloroquine NN cord-305956-l02xdq87 94 7 or or CC cord-305956-l02xdq87 94 8 hydroxychloroquine hydroxychloroquine NN cord-305956-l02xdq87 94 9 has have VBZ cord-305956-l02xdq87 94 10 rarely rarely RB cord-305956-l02xdq87 94 11 been be VBN cord-305956-l02xdq87 94 12 reported report VBN cord-305956-l02xdq87 94 13 . . . cord-305956-l02xdq87 95 1 In in IN cord-305956-l02xdq87 95 2 severe severe JJ cord-305956-l02xdq87 95 3 cases case NNS cord-305956-l02xdq87 95 4 of of IN cord-305956-l02xdq87 95 5 COVID-19 covid-19 DT cord-305956-l02xdq87 95 6 with with IN cord-305956-l02xdq87 95 7 cytokine cytokine NN cord-305956-l02xdq87 95 8 release release NN cord-305956-l02xdq87 95 9 , , , cord-305956-l02xdq87 95 10 tocilizumab tocilizumab NNP cord-305956-l02xdq87 95 11 , , , cord-305956-l02xdq87 95 12 an an DT cord-305956-l02xdq87 95 13 IL-6 IL-6 NNP cord-305956-l02xdq87 95 14 antagonist antagonist NN cord-305956-l02xdq87 95 15 , , , cord-305956-l02xdq87 95 16 which which WDT cord-305956-l02xdq87 95 17 is be VBZ cord-305956-l02xdq87 95 18 humanized humanize VBN cord-305956-l02xdq87 95 19 IgG1 igg1 CD cord-305956-l02xdq87 95 20 monoclonal monoclonal JJ cord-305956-l02xdq87 95 21 antibody antibody NN cord-305956-l02xdq87 95 22 to to IN cord-305956-l02xdq87 95 23 the the DT cord-305956-l02xdq87 95 24 IL-6 IL-6 NNP cord-305956-l02xdq87 95 25 receptor receptor NN cord-305956-l02xdq87 95 26 , , , cord-305956-l02xdq87 95 27 has have VBZ cord-305956-l02xdq87 95 28 been be VBN cord-305956-l02xdq87 95 29 used use VBN cord-305956-l02xdq87 95 30 as as IN cord-305956-l02xdq87 95 31 a a DT cord-305956-l02xdq87 95 32 potential potential JJ cord-305956-l02xdq87 95 33 therapy therapy NN cord-305956-l02xdq87 95 34 for for IN cord-305956-l02xdq87 95 35 SARS SARS NNP cord-305956-l02xdq87 95 36 - - HYPH cord-305956-l02xdq87 95 37 CoV-2 CoV-2 NNP cord-305956-l02xdq87 95 38 . . . cord-305956-l02xdq87 96 1 In in IN cord-305956-l02xdq87 96 2 previous previous JJ cord-305956-l02xdq87 96 3 clinical clinical JJ cord-305956-l02xdq87 96 4 trials trial NNS cord-305956-l02xdq87 96 5 for for IN cord-305956-l02xdq87 96 6 other other JJ cord-305956-l02xdq87 96 7 indications indication NNS cord-305956-l02xdq87 96 8 tocilizumab tocilizumab NN cord-305956-l02xdq87 96 9 was be VBD cord-305956-l02xdq87 96 10 reported report VBN cord-305956-l02xdq87 96 11 to to TO cord-305956-l02xdq87 96 12 cause cause VB cord-305956-l02xdq87 96 13 mild mild JJ cord-305956-l02xdq87 96 14 elevations elevation NNS cord-305956-l02xdq87 96 15 of of IN cord-305956-l02xdq87 96 16 LFTs lft NNS cord-305956-l02xdq87 96 17 which which WDT cord-305956-l02xdq87 96 18 were be VBD cord-305956-l02xdq87 96 19 usually usually RB cord-305956-l02xdq87 96 20 transient transient JJ cord-305956-l02xdq87 96 21 and and CC cord-305956-l02xdq87 96 22 commonly commonly RB cord-305956-l02xdq87 96 23 resolved resolve VBN cord-305956-l02xdq87 96 24 within within IN cord-305956-l02xdq87 96 25 2 2 CD cord-305956-l02xdq87 96 26 - - SYM cord-305956-l02xdq87 96 27 6 6 CD cord-305956-l02xdq87 96 28 weeks week NNS cord-305956-l02xdq87 96 29 from from IN cord-305956-l02xdq87 96 30 exposure exposure NN cord-305956-l02xdq87 96 31 . . . cord-305956-l02xdq87 97 1 37 37 CD cord-305956-l02xdq87 97 2 Remdesivir Remdesivir NNP cord-305956-l02xdq87 97 3 is be VBZ cord-305956-l02xdq87 97 4 an an DT cord-305956-l02xdq87 97 5 experimental experimental JJ cord-305956-l02xdq87 97 6 antiviral antiviral JJ cord-305956-l02xdq87 97 7 nucleotide nucleotide NN cord-305956-l02xdq87 97 8 analog analog NN cord-305956-l02xdq87 97 9 with with IN cord-305956-l02xdq87 97 10 broad broad JJ cord-305956-l02xdq87 97 11 activity activity NN cord-305956-l02xdq87 97 12 against against IN cord-305956-l02xdq87 97 13 coronaviruses coronaviruse NNS cord-305956-l02xdq87 97 14 44 44 CD cord-305956-l02xdq87 97 15 that that WDT cord-305956-l02xdq87 97 16 is be VBZ cord-305956-l02xdq87 97 17 currently currently RB cord-305956-l02xdq87 97 18 being be VBG cord-305956-l02xdq87 97 19 trialed triale VBN cord-305956-l02xdq87 97 20 for for IN cord-305956-l02xdq87 97 21 SARS SARS NNP cord-305956-l02xdq87 97 22 - - HYPH cord-305956-l02xdq87 97 23 Cov-2 Cov-2 NNP cord-305956-l02xdq87 97 24 infection infection NN cord-305956-l02xdq87 97 25 . . . cord-305956-l02xdq87 98 1 Safety safety NN cord-305956-l02xdq87 98 2 data datum NNS cord-305956-l02xdq87 98 3 from from IN cord-305956-l02xdq87 98 4 ongoing ongoing JJ cord-305956-l02xdq87 98 5 studies study NNS cord-305956-l02xdq87 98 6 will will MD cord-305956-l02xdq87 98 7 guide guide VB cord-305956-l02xdq87 98 8 on on IN cord-305956-l02xdq87 98 9 its -PRON- PRP$ cord-305956-l02xdq87 98 10 use use NN cord-305956-l02xdq87 98 11 in in IN cord-305956-l02xdq87 98 12 patients patient NNS cord-305956-l02xdq87 98 13 , , , cord-305956-l02xdq87 98 14 but but CC cord-305956-l02xdq87 98 15 so so RB cord-305956-l02xdq87 98 16 far far RB cord-305956-l02xdq87 98 17 no no DT cord-305956-l02xdq87 98 18 reports report NNS cord-305956-l02xdq87 98 19 of of IN cord-305956-l02xdq87 98 20 liver liver NN cord-305956-l02xdq87 98 21 toxicity toxicity NN cord-305956-l02xdq87 98 22 have have VBP cord-305956-l02xdq87 98 23 emerged emerge VBN cord-305956-l02xdq87 98 24 . . . cord-305956-l02xdq87 99 1 Patients patient NNS cord-305956-l02xdq87 99 2 with with IN cord-305956-l02xdq87 99 3 pre pre JJ cord-305956-l02xdq87 99 4 - - JJ cord-305956-l02xdq87 99 5 existing existing JJ cord-305956-l02xdq87 99 6 liver liver NN cord-305956-l02xdq87 99 7 disease disease NN cord-305956-l02xdq87 99 8 Scare Scare NNP cord-305956-l02xdq87 99 9 data datum NNS cord-305956-l02xdq87 99 10 has have VBZ cord-305956-l02xdq87 99 11 been be VBN cord-305956-l02xdq87 99 12 published publish VBN cord-305956-l02xdq87 99 13 for for IN cord-305956-l02xdq87 99 14 COVID-19 covid-19 JJ cord-305956-l02xdq87 99 15 infection infection NN cord-305956-l02xdq87 99 16 in in IN cord-305956-l02xdq87 99 17 patients patient NNS cord-305956-l02xdq87 99 18 with with IN cord-305956-l02xdq87 99 19 pre pre JJ cord-305956-l02xdq87 99 20 - - JJ cord-305956-l02xdq87 99 21 existing existing JJ cord-305956-l02xdq87 99 22 liver liver NN cord-305956-l02xdq87 99 23 disease disease NN cord-305956-l02xdq87 99 24 . . . cord-305956-l02xdq87 100 1 Experience experience NN cord-305956-l02xdq87 100 2 from from IN cord-305956-l02xdq87 100 3 previous previous JJ cord-305956-l02xdq87 100 4 episodes episode NNS cord-305956-l02xdq87 100 5 of of IN cord-305956-l02xdq87 100 6 coronavirus coronavirus NN cord-305956-l02xdq87 100 7 infection infection NN cord-305956-l02xdq87 100 8 can can MD cord-305956-l02xdq87 100 9 guide guide VB cord-305956-l02xdq87 100 10 on on IN cord-305956-l02xdq87 100 11 the the DT cord-305956-l02xdq87 100 12 extent extent NN cord-305956-l02xdq87 100 13 of of IN cord-305956-l02xdq87 100 14 hepatic hepatic JJ cord-305956-l02xdq87 100 15 involvement involvement NN cord-305956-l02xdq87 100 16 and and CC cord-305956-l02xdq87 100 17 on on IN cord-305956-l02xdq87 100 18 the the DT cord-305956-l02xdq87 100 19 management management NN cord-305956-l02xdq87 100 20 of of IN cord-305956-l02xdq87 100 21 patients patient NNS cord-305956-l02xdq87 100 22 with with IN cord-305956-l02xdq87 100 23 pre pre JJ cord-305956-l02xdq87 100 24 - - JJ cord-305956-l02xdq87 100 25 existing existing JJ cord-305956-l02xdq87 100 26 liver liver NN cord-305956-l02xdq87 100 27 disease disease NN cord-305956-l02xdq87 100 28 . . . cord-305956-l02xdq87 101 1 In in IN cord-305956-l02xdq87 101 2 SARS SARS NNP cord-305956-l02xdq87 101 3 , , , cord-305956-l02xdq87 101 4 the the DT cord-305956-l02xdq87 101 5 highest high JJS cord-305956-l02xdq87 101 6 mortality mortality NN cord-305956-l02xdq87 101 7 rates rate NNS cord-305956-l02xdq87 101 8 were be VBD cord-305956-l02xdq87 101 9 observed observe VBN cord-305956-l02xdq87 101 10 in in IN cord-305956-l02xdq87 101 11 the the DT cord-305956-l02xdq87 101 12 elderly elderly JJ cord-305956-l02xdq87 101 13 and and CC cord-305956-l02xdq87 101 14 adults adult NNS cord-305956-l02xdq87 101 15 with with IN cord-305956-l02xdq87 101 16 underlying underlie VBG cord-305956-l02xdq87 101 17 liver liver NN cord-305956-l02xdq87 101 18 disease disease NN cord-305956-l02xdq87 101 19 . . . cord-305956-l02xdq87 102 1 45 45 CD cord-305956-l02xdq87 103 1 Therefore therefore RB cord-305956-l02xdq87 103 2 , , , cord-305956-l02xdq87 103 3 it -PRON- PRP cord-305956-l02xdq87 103 4 has have VBZ cord-305956-l02xdq87 103 5 to to TO cord-305956-l02xdq87 103 6 be be VB cord-305956-l02xdq87 103 7 expected expect VBN cord-305956-l02xdq87 103 8 that that IN cord-305956-l02xdq87 103 9 the the DT cord-305956-l02xdq87 103 10 patients patient NNS cord-305956-l02xdq87 103 11 with with IN cord-305956-l02xdq87 103 12 COVID-19 COVID-19 NNP cord-305956-l02xdq87 103 13 are be VBP cord-305956-l02xdq87 103 14 also also RB cord-305956-l02xdq87 103 15 more more RBR cord-305956-l02xdq87 103 16 vulnerable vulnerable JJ cord-305956-l02xdq87 103 17 to to IN cord-305956-l02xdq87 103 18 hepatic hepatic JJ cord-305956-l02xdq87 103 19 injury injury NN cord-305956-l02xdq87 103 20 . . . cord-305956-l02xdq87 104 1 9 9 CD cord-305956-l02xdq87 105 1 In in IN cord-305956-l02xdq87 105 2 a a DT cord-305956-l02xdq87 105 3 case case NN cord-305956-l02xdq87 105 4 series series NN cord-305956-l02xdq87 105 5 from from IN cord-305956-l02xdq87 105 6 the the DT cord-305956-l02xdq87 105 7 Zhejiang Zhejiang NNP cord-305956-l02xdq87 105 8 province province NN cord-305956-l02xdq87 105 9 , , , cord-305956-l02xdq87 105 10 a a DT cord-305956-l02xdq87 105 11 prevalence prevalence NN cord-305956-l02xdq87 105 12 of of IN cord-305956-l02xdq87 105 13 11 11 CD cord-305956-l02xdq87 105 14 % % NN cord-305956-l02xdq87 105 15 of of IN cord-305956-l02xdq87 105 16 underlying underlie VBG cord-305956-l02xdq87 105 17 liver liver NN cord-305956-l02xdq87 105 18 disease disease NN cord-305956-l02xdq87 105 19 was be VBD cord-305956-l02xdq87 105 20 reported report VBN cord-305956-l02xdq87 105 21 . . . cord-305956-l02xdq87 106 1 About about RB cord-305956-l02xdq87 106 2 half half NN cord-305956-l02xdq87 106 3 of of IN cord-305956-l02xdq87 106 4 them -PRON- PRP cord-305956-l02xdq87 106 5 experienced experience VBD cord-305956-l02xdq87 106 6 symptoms symptom NNS cord-305956-l02xdq87 106 7 for for IN cord-305956-l02xdq87 106 8 more more JJR cord-305956-l02xdq87 106 9 than than IN cord-305956-l02xdq87 106 10 10 10 CD cord-305956-l02xdq87 106 11 days day NNS cord-305956-l02xdq87 106 12 after after IN cord-305956-l02xdq87 106 13 the the DT cord-305956-l02xdq87 106 14 illness illness NN cord-305956-l02xdq87 106 15 onset onset NN cord-305956-l02xdq87 106 16 . . . cord-305956-l02xdq87 107 1 21 21 CD cord-305956-l02xdq87 108 1 In in IN cord-305956-l02xdq87 108 2 another another DT cord-305956-l02xdq87 108 3 study study NN cord-305956-l02xdq87 108 4 from from IN cord-305956-l02xdq87 108 5 Wuhan Wuhan NNP cord-305956-l02xdq87 108 6 , , , cord-305956-l02xdq87 108 7 9 9 CD cord-305956-l02xdq87 108 8 % % NN cord-305956-l02xdq87 108 9 of of IN cord-305956-l02xdq87 108 10 patients patient NNS cord-305956-l02xdq87 108 11 had have VBD cord-305956-l02xdq87 108 12 the the DT cord-305956-l02xdq87 108 13 underlying underlying JJ cord-305956-l02xdq87 108 14 liver liver NN cord-305956-l02xdq87 108 15 disease disease NN cord-305956-l02xdq87 108 16 of of IN cord-305956-l02xdq87 108 17 cirrhosis cirrhosis NN cord-305956-l02xdq87 108 18 or or CC cord-305956-l02xdq87 108 19 hepatitis hepatitis NN cord-305956-l02xdq87 108 20 . . . cord-305956-l02xdq87 109 1 23 23 CD cord-305956-l02xdq87 110 1 Li Li NNP cord-305956-l02xdq87 110 2 et et NNP cord-305956-l02xdq87 110 3 al al NNP cord-305956-l02xdq87 110 4 . . NNP cord-305956-l02xdq87 110 5 , , , cord-305956-l02xdq87 110 6 who who WP cord-305956-l02xdq87 110 7 investigated investigate VBD cord-305956-l02xdq87 110 8 risk risk NN cord-305956-l02xdq87 110 9 factors factor NNS cord-305956-l02xdq87 110 10 involved involve VBN cord-305956-l02xdq87 110 11 with with IN cord-305956-l02xdq87 110 12 hepatic hepatic JJ cord-305956-l02xdq87 110 13 injury injury NN cord-305956-l02xdq87 110 14 , , , cord-305956-l02xdq87 110 15 stated state VBD cord-305956-l02xdq87 110 16 that that IN cord-305956-l02xdq87 110 17 two two CD cord-305956-l02xdq87 110 18 patients patient NNS cord-305956-l02xdq87 110 19 had have VBD cord-305956-l02xdq87 110 20 presented present VBN cord-305956-l02xdq87 110 21 with with IN cord-305956-l02xdq87 110 22 alcoholic alcoholic JJ cord-305956-l02xdq87 110 23 liver liver NN cord-305956-l02xdq87 110 24 disease disease NN cord-305956-l02xdq87 110 25 at at IN cord-305956-l02xdq87 110 26 baseline baseline NN cord-305956-l02xdq87 110 27 . . . cord-305956-l02xdq87 111 1 One one CD cord-305956-l02xdq87 111 2 of of IN cord-305956-l02xdq87 111 3 them -PRON- PRP cord-305956-l02xdq87 111 4 had have VBD cord-305956-l02xdq87 111 5 a a DT cord-305956-l02xdq87 111 6 moderate moderate JJ cord-305956-l02xdq87 111 7 elevation elevation NN cord-305956-l02xdq87 111 8 of of IN cord-305956-l02xdq87 111 9 ALT alt NN cord-305956-l02xdq87 111 10 ( ( -LRB- cord-305956-l02xdq87 111 11 120 120 CD cord-305956-l02xdq87 111 12 U u NN cord-305956-l02xdq87 111 13 / / SYM cord-305956-l02xdq87 111 14 L L NNP cord-305956-l02xdq87 111 15 ) ) -RRB- cord-305956-l02xdq87 111 16 within within IN cord-305956-l02xdq87 111 17 a a DT cord-305956-l02xdq87 111 18 week week NN cord-305956-l02xdq87 111 19 of of IN cord-305956-l02xdq87 111 20 hospitalization hospitalization NN cord-305956-l02xdq87 111 21 , , , cord-305956-l02xdq87 111 22 while while IN cord-305956-l02xdq87 111 23 the the DT cord-305956-l02xdq87 111 24 other other JJ cord-305956-l02xdq87 111 25 showed show VBD cord-305956-l02xdq87 111 26 no no DT cord-305956-l02xdq87 111 27 such such JJ cord-305956-l02xdq87 111 28 abnormalities abnormality NNS cord-305956-l02xdq87 111 29 . . . cord-305956-l02xdq87 112 1 11 11 CD cord-305956-l02xdq87 113 1 In in IN cord-305956-l02xdq87 113 2 the the DT cord-305956-l02xdq87 113 3 initial initial JJ cord-305956-l02xdq87 113 4 cohort cohort NN cord-305956-l02xdq87 113 5 described describe VBN cord-305956-l02xdq87 113 6 from from IN cord-305956-l02xdq87 113 7 China China NNP cord-305956-l02xdq87 113 8 , , , cord-305956-l02xdq87 113 9 2.7 2.7 CD cord-305956-l02xdq87 113 10 % % NN cord-305956-l02xdq87 113 11 exhibited exhibit VBD cord-305956-l02xdq87 113 12 hepatitis hepatitis NN cord-305956-l02xdq87 113 13 B B NNP cord-305956-l02xdq87 113 14 virus virus NN cord-305956-l02xdq87 113 15 infection infection NN cord-305956-l02xdq87 113 16 with with IN cord-305956-l02xdq87 113 17 no no DT cord-305956-l02xdq87 113 18 mention mention NN cord-305956-l02xdq87 113 19 of of IN cord-305956-l02xdq87 113 20 worsening worsen VBG cord-305956-l02xdq87 113 21 outcomes outcome NNS cord-305956-l02xdq87 113 22 . . . cord-305956-l02xdq87 114 1 26 26 CD cord-305956-l02xdq87 115 1 Therefore therefore RB cord-305956-l02xdq87 115 2 , , , cord-305956-l02xdq87 115 3 the the DT cord-305956-l02xdq87 115 4 association association NN cord-305956-l02xdq87 115 5 of of IN cord-305956-l02xdq87 115 6 the the DT cord-305956-l02xdq87 115 7 pre pre JJ cord-305956-l02xdq87 115 8 - - JJ cord-305956-l02xdq87 115 9 existing existing JJ cord-305956-l02xdq87 115 10 liver liver NN cord-305956-l02xdq87 115 11 conditions condition NNS cord-305956-l02xdq87 115 12 with with IN cord-305956-l02xdq87 115 13 disease disease NN cord-305956-l02xdq87 115 14 prognosis prognosis NN cord-305956-l02xdq87 115 15 and and CC cord-305956-l02xdq87 115 16 outcomes outcome NNS cord-305956-l02xdq87 115 17 in in IN cord-305956-l02xdq87 115 18 COVID-19 COVID-19 NNP cord-305956-l02xdq87 115 19 will will MD cord-305956-l02xdq87 115 20 have have VB cord-305956-l02xdq87 115 21 to to TO cord-305956-l02xdq87 115 22 be be VB cord-305956-l02xdq87 115 23 evaluated evaluate VBN cord-305956-l02xdq87 115 24 by by IN cord-305956-l02xdq87 115 25 comprehensive comprehensive JJ cord-305956-l02xdq87 115 26 data datum NNS cord-305956-l02xdq87 115 27 registries registry NNS cord-305956-l02xdq87 115 28 which which WDT cord-305956-l02xdq87 115 29 recently recently RB cord-305956-l02xdq87 115 30 started start VBD cord-305956-l02xdq87 115 31 enrolling enrol VBG cord-305956-l02xdq87 115 32 patients patient NNS cord-305956-l02xdq87 115 33 ( ( -LRB- cord-305956-l02xdq87 115 34 e.g. e.g. RB cord-305956-l02xdq87 115 35 COVID COVID NNP cord-305956-l02xdq87 115 36 - - HYPH cord-305956-l02xdq87 115 37 Hep Hep NNP cord-305956-l02xdq87 115 38 Registry Registry NNP cord-305956-l02xdq87 115 39 and and CC cord-305956-l02xdq87 115 40 SECURE secure JJ cord-305956-l02xdq87 115 41 - - HYPH cord-305956-l02xdq87 115 42 Cirrhosis Cirrhosis NNP cord-305956-l02xdq87 115 43 Registry Registry NNP cord-305956-l02xdq87 115 44 ) ) -RRB- cord-305956-l02xdq87 115 45 . . . cord-305956-l02xdq87 116 1 Management management NN cord-305956-l02xdq87 116 2 of of IN cord-305956-l02xdq87 116 3 post post JJ cord-305956-l02xdq87 116 4 liver liver NN cord-305956-l02xdq87 116 5 transplant transplant NN cord-305956-l02xdq87 116 6 recipients recipient NNS cord-305956-l02xdq87 116 7 during during IN cord-305956-l02xdq87 116 8 the the DT cord-305956-l02xdq87 116 9 COVID-19 COVID-19 NNP cord-305956-l02xdq87 116 10 pandemic pandemic NN cord-305956-l02xdq87 116 11 presents present VBZ cord-305956-l02xdq87 116 12 a a DT cord-305956-l02xdq87 116 13 special special JJ cord-305956-l02xdq87 116 14 challenge challenge NN cord-305956-l02xdq87 116 15 for for IN cord-305956-l02xdq87 116 16 clinicians clinician NNS cord-305956-l02xdq87 116 17 because because IN cord-305956-l02xdq87 116 18 of of IN cord-305956-l02xdq87 116 19 the the DT cord-305956-l02xdq87 116 20 limited limited JJ cord-305956-l02xdq87 116 21 data datum NNS cord-305956-l02xdq87 116 22 available available JJ cord-305956-l02xdq87 116 23 and and CC cord-305956-l02xdq87 116 24 the the DT cord-305956-l02xdq87 116 25 crucial crucial JJ cord-305956-l02xdq87 116 26 need need NN cord-305956-l02xdq87 116 27 to to TO cord-305956-l02xdq87 116 28 continue continue VB cord-305956-l02xdq87 116 29 immunosuppressive immunosuppressive JJ cord-305956-l02xdq87 116 30 drugs drug NNS cord-305956-l02xdq87 116 31 in in IN cord-305956-l02xdq87 116 32 these these DT cord-305956-l02xdq87 116 33 patients patient NNS cord-305956-l02xdq87 116 34 , , , cord-305956-l02xdq87 116 35 which which WDT cord-305956-l02xdq87 116 36 puts put VBZ cord-305956-l02xdq87 116 37 them -PRON- PRP cord-305956-l02xdq87 116 38 at at IN cord-305956-l02xdq87 116 39 risk risk NN cord-305956-l02xdq87 116 40 for for IN cord-305956-l02xdq87 116 41 more more JJR cord-305956-l02xdq87 116 42 severe severe JJ cord-305956-l02xdq87 116 43 courses course NNS cord-305956-l02xdq87 116 44 of of IN cord-305956-l02xdq87 116 45 COVID-19 covid-19 JJ cord-305956-l02xdq87 116 46 infection infection NN cord-305956-l02xdq87 116 47 and and CC cord-305956-l02xdq87 116 48 possible possible JJ cord-305956-l02xdq87 116 49 prolonged prolong VBN cord-305956-l02xdq87 116 50 viral viral JJ cord-305956-l02xdq87 116 51 shedding shedding NN cord-305956-l02xdq87 116 52 . . . cord-305956-l02xdq87 117 1 Case case NN cord-305956-l02xdq87 117 2 reports report NNS cord-305956-l02xdq87 117 3 from from IN cord-305956-l02xdq87 117 4 China China NNP cord-305956-l02xdq87 117 5 did do VBD cord-305956-l02xdq87 117 6 not not RB cord-305956-l02xdq87 117 7 reveal reveal VB cord-305956-l02xdq87 117 8 an an DT cord-305956-l02xdq87 117 9 increased increase VBN cord-305956-l02xdq87 117 10 mortality mortality NN cord-305956-l02xdq87 117 11 in in IN cord-305956-l02xdq87 117 12 organ organ NN cord-305956-l02xdq87 117 13 transplant transplant NN cord-305956-l02xdq87 117 14 recipients recipient NNS cord-305956-l02xdq87 117 15 . . . cord-305956-l02xdq87 118 1 Qin Qin NNP cord-305956-l02xdq87 118 2 et et NNP cord-305956-l02xdq87 118 3 al al NNP cord-305956-l02xdq87 118 4 . . NNP cord-305956-l02xdq87 118 5 reported report VBD cord-305956-l02xdq87 118 6 the the DT cord-305956-l02xdq87 118 7 first first JJ cord-305956-l02xdq87 118 8 case case NN cord-305956-l02xdq87 118 9 of of IN cord-305956-l02xdq87 118 10 SARS SARS NNP cord-305956-l02xdq87 118 11 - - HYPH cord-305956-l02xdq87 118 12 CoV-2 CoV-2 NNP cord-305956-l02xdq87 118 13 infection infection NN cord-305956-l02xdq87 118 14 in in IN cord-305956-l02xdq87 118 15 a a DT cord-305956-l02xdq87 118 16 patient patient NN cord-305956-l02xdq87 118 17 with with IN cord-305956-l02xdq87 118 18 hepatocellular hepatocellular JJ cord-305956-l02xdq87 118 19 carcinoma carcinoma NN cord-305956-l02xdq87 118 20 who who WP cord-305956-l02xdq87 118 21 underwent undergo VBD cord-305956-l02xdq87 118 22 liver liver NN cord-305956-l02xdq87 118 23 transplantation transplantation NN cord-305956-l02xdq87 118 24 . . . cord-305956-l02xdq87 119 1 29 29 CD cord-305956-l02xdq87 120 1 Lowering lower VBG cord-305956-l02xdq87 120 2 immunosuppression immunosuppression NN cord-305956-l02xdq87 120 3 to to IN cord-305956-l02xdq87 120 4 the the DT cord-305956-l02xdq87 120 5 most most RBS cord-305956-l02xdq87 120 6 acceptable acceptable JJ cord-305956-l02xdq87 120 7 level level NN cord-305956-l02xdq87 120 8 appears appear VBZ cord-305956-l02xdq87 120 9 reasonable reasonable JJ cord-305956-l02xdq87 120 10 in in IN cord-305956-l02xdq87 120 11 infected infected JJ cord-305956-l02xdq87 120 12 liver liver NN cord-305956-l02xdq87 120 13 transplant transplant NN cord-305956-l02xdq87 120 14 patients patient NNS cord-305956-l02xdq87 120 15 , , , cord-305956-l02xdq87 120 16 in in IN cord-305956-l02xdq87 120 17 particular particular JJ cord-305956-l02xdq87 120 18 , , , cord-305956-l02xdq87 120 19 in in IN cord-305956-l02xdq87 120 20 the the DT cord-305956-l02xdq87 120 21 setting setting NN cord-305956-l02xdq87 120 22 of of IN cord-305956-l02xdq87 120 23 lymphopenia lymphopenia NN cord-305956-l02xdq87 120 24 or or CC cord-305956-l02xdq87 120 25 clinical clinical JJ cord-305956-l02xdq87 120 26 worsening worsening NN cord-305956-l02xdq87 120 27 of of IN cord-305956-l02xdq87 120 28 infection infection NN cord-305956-l02xdq87 120 29 . . . cord-305956-l02xdq87 121 1 46 46 CD cord-305956-l02xdq87 122 1 In in IN cord-305956-l02xdq87 122 2 addition addition NN cord-305956-l02xdq87 122 3 clinicians clinician NNS cord-305956-l02xdq87 122 4 have have VBP cord-305956-l02xdq87 122 5 to to TO cord-305956-l02xdq87 122 6 be be VB cord-305956-l02xdq87 122 7 aware aware JJ cord-305956-l02xdq87 122 8 of of IN cord-305956-l02xdq87 122 9 drug drug NN cord-305956-l02xdq87 122 10 - - HYPH cord-305956-l02xdq87 122 11 drug drug NN cord-305956-l02xdq87 122 12 interactions interaction NNS cord-305956-l02xdq87 122 13 in in IN cord-305956-l02xdq87 122 14 the the DT cord-305956-l02xdq87 122 15 transplant transplant NN cord-305956-l02xdq87 122 16 setting setting NN cord-305956-l02xdq87 122 17 . . . cord-305956-l02xdq87 123 1 In in IN cord-305956-l02xdq87 123 2 particular particular JJ cord-305956-l02xdq87 123 3 immunosuppressive immunosuppressive JJ cord-305956-l02xdq87 123 4 drugs drug NNS cord-305956-l02xdq87 123 5 and and CC cord-305956-l02xdq87 123 6 ritonavir ritonavir NNS cord-305956-l02xdq87 123 7 - - HYPH cord-305956-l02xdq87 123 8 boosted boost VBN cord-305956-l02xdq87 123 9 antiviral antiviral JJ cord-305956-l02xdq87 123 10 therapies therapy NNS cord-305956-l02xdq87 123 11 exhibit exhibit VBP cord-305956-l02xdq87 123 12 relevant relevant JJ cord-305956-l02xdq87 123 13 interactions interaction NNS cord-305956-l02xdq87 123 14 through through IN cord-305956-l02xdq87 123 15 CYP34A CYP34A NNP cord-305956-l02xdq87 123 16 which which WDT cord-305956-l02xdq87 123 17 lead lead VBP cord-305956-l02xdq87 123 18 to to IN cord-305956-l02xdq87 123 19 increased increase VBN cord-305956-l02xdq87 123 20 levels level NNS cord-305956-l02xdq87 123 21 of of IN cord-305956-l02xdq87 123 22 calcineurin calcineurin NNP cord-305956-l02xdq87 123 23 and and CC cord-305956-l02xdq87 123 24 mTOR mTOR NNP cord-305956-l02xdq87 123 25 inhibitors inhibitor NNS cord-305956-l02xdq87 123 26 . . . cord-305956-l02xdq87 124 1 Accordingly accordingly RB cord-305956-l02xdq87 124 2 , , , cord-305956-l02xdq87 124 3 chloroquine chloroquine NN cord-305956-l02xdq87 124 4 - - HYPH cord-305956-l02xdq87 124 5 based base VBN cord-305956-l02xdq87 124 6 regimes regime NNS cord-305956-l02xdq87 124 7 or or CC cord-305956-l02xdq87 124 8 remdesivir remdesivir JJ cord-305956-l02xdq87 124 9 ( ( -LRB- cord-305956-l02xdq87 124 10 compassionate compassionate JJ cord-305956-l02xdq87 124 11 use use NN cord-305956-l02xdq87 124 12 program program NN cord-305956-l02xdq87 124 13 only only RB cord-305956-l02xdq87 124 14 ) ) -RRB- cord-305956-l02xdq87 124 15 appear appear VBP cord-305956-l02xdq87 124 16 to to TO cord-305956-l02xdq87 124 17 be be VB cord-305956-l02xdq87 124 18 safe safe JJ cord-305956-l02xdq87 124 19 , , , cord-305956-l02xdq87 124 20 while while IN cord-305956-l02xdq87 124 21 boosted boost VBN cord-305956-l02xdq87 124 22 protease protease NN cord-305956-l02xdq87 124 23 inhibitors inhibitor NNS cord-305956-l02xdq87 124 24 should should MD cord-305956-l02xdq87 124 25 be be VB cord-305956-l02xdq87 124 26 avoided avoid VBN cord-305956-l02xdq87 124 27 ( ( -LRB- cord-305956-l02xdq87 124 28 see see VB cord-305956-l02xdq87 124 29 Table table NN cord-305956-l02xdq87 124 30 2 2 CD cord-305956-l02xdq87 124 31 ) ) -RRB- cord-305956-l02xdq87 124 32 . . . cord-305956-l02xdq87 125 1 Additionally additionally RB cord-305956-l02xdq87 125 2 , , , cord-305956-l02xdq87 125 3 preventive preventive JJ cord-305956-l02xdq87 125 4 strategies strategy NNS cord-305956-l02xdq87 125 5 in in IN cord-305956-l02xdq87 125 6 those those DT cord-305956-l02xdq87 125 7 vulnerable vulnerable JJ cord-305956-l02xdq87 125 8 patients patient NNS cord-305956-l02xdq87 125 9 include include VBP cord-305956-l02xdq87 125 10 early early JJ cord-305956-l02xdq87 125 11 and and CC cord-305956-l02xdq87 125 12 prolonged prolonged JJ cord-305956-l02xdq87 125 13 screening screening NN cord-305956-l02xdq87 125 14 with with IN cord-305956-l02xdq87 125 15 polymerase polymerase NN cord-305956-l02xdq87 125 16 chain chain NN cord-305956-l02xdq87 125 17 reaction reaction NN cord-305956-l02xdq87 125 18 - - HYPH cord-305956-l02xdq87 125 19 based base VBN cord-305956-l02xdq87 125 20 testing testing NN cord-305956-l02xdq87 125 21 for for IN cord-305956-l02xdq87 125 22 patients patient NNS cord-305956-l02xdq87 125 23 with with IN cord-305956-l02xdq87 125 24 early early JJ cord-305956-l02xdq87 125 25 symptoms symptom NNS cord-305956-l02xdq87 125 26 , , , cord-305956-l02xdq87 125 27 a a DT cord-305956-l02xdq87 125 28 contact contact NN cord-305956-l02xdq87 125 29 history history NN cord-305956-l02xdq87 125 30 or or CC cord-305956-l02xdq87 125 31 infection infection NN cord-305956-l02xdq87 125 32 . . . cord-305956-l02xdq87 126 1 Personal personal JJ cord-305956-l02xdq87 126 2 _SP cord-305956-l02xdq87 126 3 Liver Liver NNP cord-305956-l02xdq87 126 4 function function NN cord-305956-l02xdq87 126 5 abnormalities abnormality NNS cord-305956-l02xdq87 126 6 -predominantly -predominantly RB cord-305956-l02xdq87 127 1 AST AST NNP cord-305956-l02xdq87 127 2 elevation elevation NN cord-305956-l02xdq87 127 3 -in -in . cord-305956-l02xdq87 128 1 COVID-19 COVID-19 NNP cord-305956-l02xdq87 128 2 appear appear VBP cord-305956-l02xdq87 128 3 to to TO cord-305956-l02xdq87 128 4 be be VB cord-305956-l02xdq87 128 5 frequent frequent JJ cord-305956-l02xdq87 128 6 but but CC cord-305956-l02xdq87 128 7 not not RB cord-305956-l02xdq87 128 8 severe severe JJ cord-305956-l02xdq87 128 9 in in IN cord-305956-l02xdq87 128 10 most most JJS cord-305956-l02xdq87 128 11 cases case NNS cord-305956-l02xdq87 128 12 . . . cord-305956-l02xdq87 129 1 Direct direct JJ cord-305956-l02xdq87 129 2 viral viral JJ cord-305956-l02xdq87 129 3 hepatotoxicity hepatotoxicity NN cord-305956-l02xdq87 129 4 , , , cord-305956-l02xdq87 129 5 DILI DILI NNP cord-305956-l02xdq87 129 6 , , , cord-305956-l02xdq87 129 7 ' ' '' cord-305956-l02xdq87 129 8 bystander bystander NN cord-305956-l02xdq87 129 9 effects effect NNS cord-305956-l02xdq87 129 10 ' ' '' cord-305956-l02xdq87 129 11 during during IN cord-305956-l02xdq87 129 12 a a DT cord-305956-l02xdq87 129 13 systemic systemic JJ cord-305956-l02xdq87 129 14 viral viral JJ cord-305956-l02xdq87 129 15 infection infection NN cord-305956-l02xdq87 129 16 and and CC cord-305956-l02xdq87 129 17 potentially potentially RB cord-305956-l02xdq87 129 18 sepsis sepsis NN cord-305956-l02xdq87 129 19 , , , cord-305956-l02xdq87 129 20 or or CC cord-305956-l02xdq87 129 21 exacerbation exacerbation NN cord-305956-l02xdq87 129 22 of of IN cord-305956-l02xdq87 129 23 an an DT cord-305956-l02xdq87 129 24 underlying underlie VBG cord-305956-l02xdq87 129 25 liver liver NN cord-305956-l02xdq87 129 26 disease disease NN cord-305956-l02xdq87 129 27 have have VBP cord-305956-l02xdq87 129 28 to to TO cord-305956-l02xdq87 129 29 be be VB cord-305956-l02xdq87 129 30 considered consider VBN cord-305956-l02xdq87 129 31 . . . cord-305956-l02xdq87 130 1 Ex Ex NNP cord-305956-l02xdq87 130 2 vivo vivo NNP cord-305956-l02xdq87 130 3 studies study NNS cord-305956-l02xdq87 130 4 offer offer VBP cord-305956-l02xdq87 130 5 that that IN cord-305956-l02xdq87 130 6 SARS SARS NNP cord-305956-l02xdq87 130 7 - - HYPH cord-305956-l02xdq87 130 8 CoV-2 CoV-2 NNP cord-305956-l02xdq87 130 9 can can MD cord-305956-l02xdq87 130 10 selectively selectively RB cord-305956-l02xdq87 130 11 target target VB cord-305956-l02xdq87 130 12 the the DT cord-305956-l02xdq87 130 13 liver liver NN cord-305956-l02xdq87 130 14 , , , cord-305956-l02xdq87 130 15 in in IN cord-305956-l02xdq87 130 16 particular particular JJ cord-305956-l02xdq87 130 17 cholangiocytes cholangiocyte NNS cord-305956-l02xdq87 130 18 through through IN cord-305956-l02xdq87 130 19 ACE2 ACE2 NNP cord-305956-l02xdq87 130 20 , , , cord-305956-l02xdq87 130 21 and and CC cord-305956-l02xdq87 130 22 thus thus RB cord-305956-l02xdq87 130 23 hepatobiliary hepatobiliary NNP cord-305956-l02xdq87 130 24 injury injury NNP cord-305956-l02xdq87 130 25 appears appear VBZ cord-305956-l02xdq87 130 26 plausible plausible JJ cord-305956-l02xdq87 130 27 . . . cord-305956-l02xdq87 131 1 Irrespective irrespective RB cord-305956-l02xdq87 131 2 of of IN cord-305956-l02xdq87 131 3 the the DT cord-305956-l02xdq87 131 4 mechanisms mechanism NNS cord-305956-l02xdq87 131 5 involved involve VBN cord-305956-l02xdq87 131 6 in in IN cord-305956-l02xdq87 131 7 the the DT cord-305956-l02xdq87 131 8 hepatic hepatic JJ cord-305956-l02xdq87 131 9 injury injury NN cord-305956-l02xdq87 131 10 of of IN cord-305956-l02xdq87 131 11 patients patient NNS cord-305956-l02xdq87 131 12 with with IN cord-305956-l02xdq87 131 13 COVID-19 COVID-19 NNP cord-305956-l02xdq87 131 14 , , , cord-305956-l02xdq87 131 15 activation activation NN cord-305956-l02xdq87 131 16 of of IN cord-305956-l02xdq87 131 17 the the DT cord-305956-l02xdq87 131 18 immune immune NN cord-305956-l02xdq87 131 19 - - HYPH cord-305956-l02xdq87 131 20 mediated mediate VBN cord-305956-l02xdq87 131 21 pathway pathway NN cord-305956-l02xdq87 131 22 seems seem VBZ cord-305956-l02xdq87 131 23 to to TO cord-305956-l02xdq87 131 24 be be VB cord-305956-l02xdq87 131 25 critical critical JJ cord-305956-l02xdq87 131 26 . . . cord-305956-l02xdq87 132 1 Special special JJ cord-305956-l02xdq87 132 2 high high JJ cord-305956-l02xdq87 132 3 risk risk NN cord-305956-l02xdq87 132 4 populations population NNS cord-305956-l02xdq87 132 5 require require VBP cord-305956-l02xdq87 132 6 close close JJ cord-305956-l02xdq87 132 7 monitoring monitoring NN cord-305956-l02xdq87 132 8 . . . cord-305956-l02xdq87 133 1 These these DT cord-305956-l02xdq87 133 2 include include VBP cord-305956-l02xdq87 133 3 the the DT cord-305956-l02xdq87 133 4 elderly elderly JJ cord-305956-l02xdq87 133 5 population population NN cord-305956-l02xdq87 133 6 , , , cord-305956-l02xdq87 133 7 patients patient NNS cord-305956-l02xdq87 133 8 with with IN cord-305956-l02xdq87 133 9 endstage endstage NN cord-305956-l02xdq87 133 10 liver liver NN cord-305956-l02xdq87 133 11 disease disease NN cord-305956-l02xdq87 133 12 and and CC cord-305956-l02xdq87 133 13 liver liver NN cord-305956-l02xdq87 133 14 transplant transplant NN cord-305956-l02xdq87 133 15 recipients recipient NNS cord-305956-l02xdq87 133 16 . . . cord-305956-l02xdq87 134 1 Symptomatic symptomatic JJ cord-305956-l02xdq87 134 2 treatment treatment NN cord-305956-l02xdq87 134 3 with with IN cord-305956-l02xdq87 134 4 acetaminophen acetaminophen NN cord-305956-l02xdq87 134 5 and and CC cord-305956-l02xdq87 134 6 avoidance avoidance NN cord-305956-l02xdq87 134 7 of of IN cord-305956-l02xdq87 134 8 non non JJ cord-305956-l02xdq87 134 9 - - JJ cord-305956-l02xdq87 134 10 steroidal steroidal JJ cord-305956-l02xdq87 134 11 anti anti JJ cord-305956-l02xdq87 134 12 - - JJ cord-305956-l02xdq87 134 13 inflammatory inflammatory JJ cord-305956-l02xdq87 134 14 drugs drug NNS cord-305956-l02xdq87 134 15 in in IN cord-305956-l02xdq87 134 16 cirrhosis cirrhosis NN cord-305956-l02xdq87 134 17 is be VBZ cord-305956-l02xdq87 134 18 recommended recommend VBN cord-305956-l02xdq87 134 19 . . . cord-305956-l02xdq87 135 1 Cautious cautious JJ cord-305956-l02xdq87 135 2 use use NN cord-305956-l02xdq87 135 3 of of IN cord-305956-l02xdq87 135 4 antiviral antiviral JJ cord-305956-l02xdq87 135 5 agents agent NNS cord-305956-l02xdq87 135 6 in in IN cord-305956-l02xdq87 135 7 patients patient NNS cord-305956-l02xdq87 135 8 with with IN cord-305956-l02xdq87 135 9 decompensated decompensated JJ cord-305956-l02xdq87 135 10 liver liver NN cord-305956-l02xdq87 135 11 disease disease NN cord-305956-l02xdq87 135 12 and and CC cord-305956-l02xdq87 135 13 drug drug NN cord-305956-l02xdq87 135 14 - - HYPH cord-305956-l02xdq87 135 15 drug drug NN cord-305956-l02xdq87 135 16 interactions interaction NNS cord-305956-l02xdq87 135 17 in in IN cord-305956-l02xdq87 135 18 post post JJ cord-305956-l02xdq87 135 19 liver liver NN cord-305956-l02xdq87 135 20 transplant transplant NN cord-305956-l02xdq87 135 21 patients patient NNS cord-305956-l02xdq87 135 22 has have VBZ cord-305956-l02xdq87 135 23 to to TO cord-305956-l02xdq87 135 24 be be VB cord-305956-l02xdq87 135 25 considered consider VBN cord-305956-l02xdq87 135 26 . . . cord-305956-l02xdq87 136 1 As as IN cord-305956-l02xdq87 136 2 emphasized emphasize VBN cord-305956-l02xdq87 136 3 by by IN cord-305956-l02xdq87 136 4 a a DT cord-305956-l02xdq87 136 5 recent recent JJ cord-305956-l02xdq87 136 6 position position NN cord-305956-l02xdq87 136 7 paper paper NN cord-305956-l02xdq87 136 8 of of IN cord-305956-l02xdq87 136 9 the the DT cord-305956-l02xdq87 136 10 European European NNP cord-305956-l02xdq87 136 11 Study Study NNP cord-305956-l02xdq87 136 12 of of IN cord-305956-l02xdq87 136 13 Liver Liver NNP cord-305956-l02xdq87 136 14 Disease Disease NNP cord-305956-l02xdq87 136 15 , , , cord-305956-l02xdq87 136 16 elective elective JJ cord-305956-l02xdq87 136 17 procedures procedure NNS cord-305956-l02xdq87 136 18 and and CC cord-305956-l02xdq87 136 19 routine routine JJ cord-305956-l02xdq87 136 20 tests test NNS cord-305956-l02xdq87 136 21 should should MD cord-305956-l02xdq87 136 22 be be VB cord-305956-l02xdq87 136 23 postponed postpone VBN cord-305956-l02xdq87 136 24 according accord VBG cord-305956-l02xdq87 136 25 to to IN cord-305956-l02xdq87 136 26 the the DT cord-305956-l02xdq87 136 27 risk risk NN cord-305956-l02xdq87 136 28 - - HYPH cord-305956-l02xdq87 136 29 benefit benefit NN cord-305956-l02xdq87 136 30 at at IN cord-305956-l02xdq87 136 31 the the DT cord-305956-l02xdq87 136 32 given give VBN cord-305956-l02xdq87 136 33 time time NN cord-305956-l02xdq87 136 34 . . . cord-305956-l02xdq87 137 1 On on IN cord-305956-l02xdq87 137 2 the the DT cord-305956-l02xdq87 137 3 other other JJ cord-305956-l02xdq87 137 4 hand hand NN cord-305956-l02xdq87 137 5 , , , cord-305956-l02xdq87 137 6 emergency emergency NN cord-305956-l02xdq87 137 7 medical medical JJ cord-305956-l02xdq87 137 8 care care NN cord-305956-l02xdq87 137 9 needs need VBZ cord-305956-l02xdq87 137 10 to to TO cord-305956-l02xdq87 137 11 be be VB cord-305956-l02xdq87 137 12 done do VBN cord-305956-l02xdq87 137 13 with with IN cord-305956-l02xdq87 137 14 appropriate appropriate JJ cord-305956-l02xdq87 137 15 measures measure NNS cord-305956-l02xdq87 137 16 to to TO cord-305956-l02xdq87 137 17 prevent prevent VB cord-305956-l02xdq87 137 18 infection infection NN cord-305956-l02xdq87 137 19 . . . cord-305956-l02xdq87 138 1 46 46 CD cord-305956-l02xdq87 138 2 Declaration Declaration NNP cord-305956-l02xdq87 138 3 of of IN cord-305956-l02xdq87 138 4 conflicting conflict VBG cord-305956-l02xdq87 138 5 interests interest NNS cord-305956-l02xdq87 138 6 SA SA NNP cord-305956-l02xdq87 138 7 has have VBZ cord-305956-l02xdq87 138 8 nothing nothing NN cord-305956-l02xdq87 138 9 to to TO cord-305956-l02xdq87 138 10 declare declare VB cord-305956-l02xdq87 138 11 . . . cord-305956-l02xdq87 139 1 JMS JMS NNP cord-305956-l02xdq87 139 2 has have VBZ cord-305956-l02xdq87 139 3 acted act VBN cord-305956-l02xdq87 139 4 independently independently RB cord-305956-l02xdq87 139 5 of of IN cord-305956-l02xdq87 139 6 this this DT cord-305956-l02xdq87 139 7 study study NN cord-305956-l02xdq87 139 8 as as IN cord-305956-l02xdq87 139 9 a a DT cord-305956-l02xdq87 139 10 consultant consultant NN cord-305956-l02xdq87 139 11 to to IN cord-305956-l02xdq87 139 12 Boehringer Boehringer NNP cord-305956-l02xdq87 139 13 Ingelheim Ingelheim NNP cord-305956-l02xdq87 139 14 , , , cord-305956-l02xdq87 139 15 Galmed Galmed NNP cord-305956-l02xdq87 139 16 , , , cord-305956-l02xdq87 139 17 Genfit Genfit NNP cord-305956-l02xdq87 139 18 , , , cord-305956-l02xdq87 139 19 Gilead Gilead NNP cord-305956-l02xdq87 139 20 Sciences Sciences NNPS cord-305956-l02xdq87 139 21 , , , cord-305956-l02xdq87 139 22 Intercept Intercept NNP cord-305956-l02xdq87 139 23 Pharmaceuticals Pharmaceuticals NNP cord-305956-l02xdq87 139 24 , , , cord-305956-l02xdq87 139 25 Novartis Novartis NNP cord-305956-l02xdq87 139 26 , , , cord-305956-l02xdq87 139 27 Roche Roche NNP cord-305956-l02xdq87 139 28 , , , cord-305956-l02xdq87 139 29 Siemens Siemens NNP cord-305956-l02xdq87 139 30 Healthineers Healthineers NNP cord-305956-l02xdq87 139 31 , , , cord-305956-l02xdq87 139 32 and and CC cord-305956-l02xdq87 139 33 has have VBZ cord-305956-l02xdq87 139 34 received receive VBN cord-305956-l02xdq87 139 35 research research NN cord-305956-l02xdq87 139 36 funding funding NN cord-305956-l02xdq87 139 37 from from IN cord-305956-l02xdq87 139 38 Gilead Gilead NNP cord-305956-l02xdq87 139 39 Sciences Sciences NNPS cord-305956-l02xdq87 139 40 . . . cord-305956-l02xdq87 140 1 Clinical clinical JJ cord-305956-l02xdq87 140 2 characteristics characteristic NNS cord-305956-l02xdq87 140 3 and and CC cord-305956-l02xdq87 140 4 mechanism mechanism NN cord-305956-l02xdq87 140 5 of of IN cord-305956-l02xdq87 140 6 liver liver NN cord-305956-l02xdq87 140 7 damage damage NN cord-305956-l02xdq87 140 8 in in IN cord-305956-l02xdq87 140 9 patients patient NNS cord-305956-l02xdq87 140 10 with with IN cord-305956-l02xdq87 140 11 severe severe JJ cord-305956-l02xdq87 140 12 acute acute JJ cord-305956-l02xdq87 140 13 respiratory respiratory JJ cord-305956-l02xdq87 140 14 syndrome syndrome NN cord-305956-l02xdq87 140 15 Fatal fatal JJ cord-305956-l02xdq87 140 16 severe severe JJ cord-305956-l02xdq87 140 17 acute acute JJ cord-305956-l02xdq87 140 18 respiratory respiratory JJ cord-305956-l02xdq87 140 19 syndrome syndrome NN cord-305956-l02xdq87 140 20 is be VBZ cord-305956-l02xdq87 140 21 associated associate VBN cord-305956-l02xdq87 140 22 with with IN cord-305956-l02xdq87 140 23 multiorgan multiorgan NN cord-305956-l02xdq87 140 24 involvement involvement NN cord-305956-l02xdq87 140 25 by by IN cord-305956-l02xdq87 140 26 coronavirus coronavirus NN cord-305956-l02xdq87 140 27 Pathological pathological JJ cord-305956-l02xdq87 140 28 findings finding NNS cord-305956-l02xdq87 140 29 of of IN cord-305956-l02xdq87 140 30 COVID-19 COVID-19 NNP cord-305956-l02xdq87 140 31 associated associate VBN cord-305956-l02xdq87 140 32 with with IN cord-305956-l02xdq87 140 33 acute acute JJ cord-305956-l02xdq87 140 34 respiratory respiratory JJ cord-305956-l02xdq87 140 35 distress distress NN cord-305956-l02xdq87 140 36 syndrome syndrome NN cord-305956-l02xdq87 140 37 SARS SARS NNP cord-305956-l02xdq87 140 38 - - HYPH cord-305956-l02xdq87 140 39 CoV-2 CoV-2 NNP cord-305956-l02xdq87 140 40 cell cell NN cord-305956-l02xdq87 140 41 entry entry NN cord-305956-l02xdq87 140 42 depends depend VBZ cord-305956-l02xdq87 140 43 on on IN cord-305956-l02xdq87 140 44 ACE2 ACE2 NNP cord-305956-l02xdq87 140 45 and and CC cord-305956-l02xdq87 140 46 TMPRSS2 TMPRSS2 NNP cord-305956-l02xdq87 140 47 and and CC cord-305956-l02xdq87 140 48 is be VBZ cord-305956-l02xdq87 140 49 blocked block VBN cord-305956-l02xdq87 140 50 by by IN cord-305956-l02xdq87 140 51 a a DT cord-305956-l02xdq87 140 52 clinically clinically RB cord-305956-l02xdq87 140 53 proven prove VBN cord-305956-l02xdq87 140 54 protease protease NN cord-305956-l02xdq87 140 55 inhibitor inhibitor NN cord-305956-l02xdq87 140 56 Highly highly RB cord-305956-l02xdq87 140 57 ACE2 ACE2 NNP cord-305956-l02xdq87 140 58 expression expression NN cord-305956-l02xdq87 140 59 in in IN cord-305956-l02xdq87 140 60 pancreas pancrea NNS cord-305956-l02xdq87 140 61 may may MD cord-305956-l02xdq87 140 62 cause cause VB cord-305956-l02xdq87 140 63 pancreas pancreas NN cord-305956-l02xdq87 140 64 damage damage NN cord-305956-l02xdq87 140 65 after after IN cord-305956-l02xdq87 140 66 SARS SARS NNP cord-305956-l02xdq87 140 67 - - HYPH cord-305956-l02xdq87 140 68 CoV-2 CoV-2 NNP cord-305956-l02xdq87 140 69 infection infection NN cord-305956-l02xdq87 140 70 Specific specific JJ cord-305956-l02xdq87 140 71 ACE2 ACE2 NNP cord-305956-l02xdq87 140 72 expression expression NN cord-305956-l02xdq87 140 73 in in IN cord-305956-l02xdq87 140 74 cholangiocytes cholangiocyte NNS cord-305956-l02xdq87 140 75 may may MD cord-305956-l02xdq87 140 76 cause cause VB cord-305956-l02xdq87 140 77 liver liver NN cord-305956-l02xdq87 140 78 damage damage NN cord-305956-l02xdq87 140 79 after after IN cord-305956-l02xdq87 140 80 2019-nCoV 2019-ncov CD cord-305956-l02xdq87 140 81 infection infection NN cord-305956-l02xdq87 140 82 Clinical Clinical NNP cord-305956-l02xdq87 140 83 Features Features NNPS cord-305956-l02xdq87 140 84 of of IN cord-305956-l02xdq87 140 85 COVID-19 covid-19 JJ cord-305956-l02xdq87 140 86 related related JJ cord-305956-l02xdq87 140 87 liver liver NN cord-305956-l02xdq87 140 88 damage damage NN cord-305956-l02xdq87 140 89 Liver liver NN cord-305956-l02xdq87 140 90 injury injury NN cord-305956-l02xdq87 140 91 in in IN cord-305956-l02xdq87 140 92 COVID-19 COVID-19 NNP cord-305956-l02xdq87 140 93 : : : cord-305956-l02xdq87 140 94 Management management NN cord-305956-l02xdq87 140 95 and and CC cord-305956-l02xdq87 140 96 challenges challenge VBZ cord-305956-l02xdq87 140 97 Liver liver NN cord-305956-l02xdq87 140 98 injury injury NN cord-305956-l02xdq87 140 99 during during IN cord-305956-l02xdq87 140 100 highly highly RB cord-305956-l02xdq87 140 101 pathogenic pathogenic JJ cord-305956-l02xdq87 140 102 human human JJ cord-305956-l02xdq87 140 103 coronavirus coronavirus NN cord-305956-l02xdq87 140 104 infections infection NNS cord-305956-l02xdq87 140 105 . . . cord-305956-l02xdq87 141 1 Liver liver NN cord-305956-l02xdq87 141 2 Int Int NNP cord-305956-l02xdq87 141 3 . . . cord-305956-l02xdq87 141 4 Epub Epub NNP cord-305956-l02xdq87 141 5 ahead ahead RB cord-305956-l02xdq87 141 6 of of IN cord-305956-l02xdq87 141 7 print print NN cord-305956-l02xdq87 141 8 14 14 CD cord-305956-l02xdq87 141 9 Recapitulation Recapitulation NNP cord-305956-l02xdq87 141 10 of of IN cord-305956-l02xdq87 141 11 SARS SARS NNP cord-305956-l02xdq87 141 12 - - HYPH cord-305956-l02xdq87 141 13 CoV-2 CoV-2 NNP cord-305956-l02xdq87 141 14 infection infection NN cord-305956-l02xdq87 141 15 and and CC cord-305956-l02xdq87 141 16 cholangiocyte cholangiocyte NNP cord-305956-l02xdq87 141 17 damage damage NN cord-305956-l02xdq87 141 18 with with IN cord-305956-l02xdq87 141 19 human human JJ cord-305956-l02xdq87 141 20 liver liver NN cord-305956-l02xdq87 141 21 organoids organoids NNP cord-305956-l02xdq87 141 22 Risk Risk NNP cord-305956-l02xdq87 141 23 factors factor NNS cord-305956-l02xdq87 141 24 related relate VBN cord-305956-l02xdq87 141 25 to to IN cord-305956-l02xdq87 141 26 hepatic hepatic JJ cord-305956-l02xdq87 141 27 injury injury NN cord-305956-l02xdq87 141 28 in in IN cord-305956-l02xdq87 141 29 patients patient NNS cord-305956-l02xdq87 141 30 with with IN cord-305956-l02xdq87 141 31 corona corona NN cord-305956-l02xdq87 141 32 virus virus NN cord-305956-l02xdq87 141 33 disease disease NN cord-305956-l02xdq87 141 34 2019 2019 CD cord-305956-l02xdq87 141 35 Clinical clinical JJ cord-305956-l02xdq87 141 36 features feature NNS cord-305956-l02xdq87 141 37 of of IN cord-305956-l02xdq87 141 38 patients patient NNS cord-305956-l02xdq87 141 39 infected infect VBN cord-305956-l02xdq87 141 40 with with IN cord-305956-l02xdq87 141 41 2019 2019 CD cord-305956-l02xdq87 141 42 novel novel JJ cord-305956-l02xdq87 141 43 coronavirus coronavirus NN cord-305956-l02xdq87 141 44 in in IN cord-305956-l02xdq87 141 45 Wuhan Wuhan NNP cord-305956-l02xdq87 141 46 , , , cord-305956-l02xdq87 142 1 China China NNP cord-305956-l02xdq87 142 2 A a DT cord-305956-l02xdq87 142 3 55-day 55-day CD cord-305956-l02xdq87 142 4 - - HYPH cord-305956-l02xdq87 142 5 old old JJ cord-305956-l02xdq87 142 6 female female JJ cord-305956-l02xdq87 142 7 infant infant NN cord-305956-l02xdq87 142 8 infected infect VBN cord-305956-l02xdq87 142 9 with with IN cord-305956-l02xdq87 142 10 COVID COVID NNP cord-305956-l02xdq87 142 11 19 19 CD cord-305956-l02xdq87 142 12 : : : cord-305956-l02xdq87 143 1 Presenting present VBG cord-305956-l02xdq87 143 2 with with IN cord-305956-l02xdq87 143 3 pneumonia pneumonia NN cord-305956-l02xdq87 143 4 , , , cord-305956-l02xdq87 143 5 liver liver NN cord-305956-l02xdq87 143 6 injury injury NN cord-305956-l02xdq87 143 7 , , , cord-305956-l02xdq87 143 8 and and CC cord-305956-l02xdq87 143 9 heart heart NN cord-305956-l02xdq87 143 10 damage damage NN cord-305956-l02xdq87 144 1 COVID-19 covid-19 JJ cord-305956-l02xdq87 144 2 infection infection NN cord-305956-l02xdq87 144 3 : : : cord-305956-l02xdq87 144 4 The the DT cord-305956-l02xdq87 144 5 perspectives perspective NNS cord-305956-l02xdq87 144 6 on on IN cord-305956-l02xdq87 144 7 immune immune JJ cord-305956-l02xdq87 144 8 responses response NNS cord-305956-l02xdq87 144 9 COVID-19 covid-19 VBP cord-305956-l02xdq87 144 10 : : : cord-305956-l02xdq87 144 11 consider consider VB cord-305956-l02xdq87 144 12 cytokine cytokine JJ cord-305956-l02xdq87 144 13 storm storm NN cord-305956-l02xdq87 144 14 syndromes syndrome NNS cord-305956-l02xdq87 144 15 and and CC cord-305956-l02xdq87 144 16 immunosuppression immunosuppression NN cord-305956-l02xdq87 144 17 Innate innate JJ cord-305956-l02xdq87 144 18 immune immune JJ cord-305956-l02xdq87 144 19 cell cell NN cord-305956-l02xdq87 144 20 trafficking trafficking NN cord-305956-l02xdq87 144 21 and and CC cord-305956-l02xdq87 144 22 function function NN cord-305956-l02xdq87 144 23 during during IN cord-305956-l02xdq87 144 24 sterile sterile JJ cord-305956-l02xdq87 144 25 inflammation inflammation NN cord-305956-l02xdq87 144 26 of of IN cord-305956-l02xdq87 144 27 the the DT cord-305956-l02xdq87 144 28 liver liver NN cord-305956-l02xdq87 144 29 Epidemiological epidemiological JJ cord-305956-l02xdq87 144 30 and and CC cord-305956-l02xdq87 144 31 clinical clinical JJ cord-305956-l02xdq87 144 32 characteristics characteristic NNS cord-305956-l02xdq87 144 33 of of IN cord-305956-l02xdq87 144 34 99 99 CD cord-305956-l02xdq87 144 35 cases case NNS cord-305956-l02xdq87 144 36 of of IN cord-305956-l02xdq87 144 37 2019 2019 CD cord-305956-l02xdq87 144 38 novel novel JJ cord-305956-l02xdq87 144 39 coronavirus coronavirus NN cord-305956-l02xdq87 144 40 pneumonia pneumonia NN cord-305956-l02xdq87 144 41 in in IN cord-305956-l02xdq87 144 42 Wuhan Wuhan NNP cord-305956-l02xdq87 144 43 , , , cord-305956-l02xdq87 144 44 China China NNP cord-305956-l02xdq87 144 45 : : : cord-305956-l02xdq87 145 1 A a DT cord-305956-l02xdq87 145 2 descriptive descriptive JJ cord-305956-l02xdq87 145 3 study study NN cord-305956-l02xdq87 146 1 Clinical clinical JJ cord-305956-l02xdq87 146 2 course course NN cord-305956-l02xdq87 146 3 and and CC cord-305956-l02xdq87 146 4 outcomes outcome NNS cord-305956-l02xdq87 146 5 of of IN cord-305956-l02xdq87 146 6 critically critically RB cord-305956-l02xdq87 146 7 ill ill JJ cord-305956-l02xdq87 146 8 patients patient NNS cord-305956-l02xdq87 146 9 with with IN cord-305956-l02xdq87 146 10 SARS SARS NNP cord-305956-l02xdq87 146 11 - - HYPH cord-305956-l02xdq87 146 12 CoV-2 CoV-2 NNP cord-305956-l02xdq87 146 13 pneumonia pneumonia NN cord-305956-l02xdq87 146 14 in in IN cord-305956-l02xdq87 146 15 Wuhan Wuhan NNP cord-305956-l02xdq87 146 16 , , , cord-305956-l02xdq87 146 17 China China NNP cord-305956-l02xdq87 146 18 : : : cord-305956-l02xdq87 147 1 A a DT cord-305956-l02xdq87 147 2 single single RB cord-305956-l02xdq87 147 3 - - HYPH cord-305956-l02xdq87 147 4 centered centered JJ cord-305956-l02xdq87 147 5 , , , cord-305956-l02xdq87 147 6 retrospective retrospective JJ cord-305956-l02xdq87 147 7 , , , cord-305956-l02xdq87 147 8 observational observational JJ cord-305956-l02xdq87 147 9 study study NN cord-305956-l02xdq87 147 10 Clinical clinical JJ cord-305956-l02xdq87 147 11 characteristics characteristic NNS cord-305956-l02xdq87 147 12 of of IN cord-305956-l02xdq87 147 13 82 82 CD cord-305956-l02xdq87 147 14 death death NN cord-305956-l02xdq87 147 15 cases case NNS cord-305956-l02xdq87 147 16 with with IN cord-305956-l02xdq87 147 17 COVID-19 COVID-19 NNP cord-305956-l02xdq87 147 18 Epidemiological epidemiological JJ cord-305956-l02xdq87 147 19 and and CC cord-305956-l02xdq87 147 20 clinical clinical JJ cord-305956-l02xdq87 147 21 features feature NNS cord-305956-l02xdq87 147 22 of of IN cord-305956-l02xdq87 147 23 the the DT cord-305956-l02xdq87 147 24 2019 2019 CD cord-305956-l02xdq87 147 25 novel novel JJ cord-305956-l02xdq87 147 26 coronavirus coronavirus NN cord-305956-l02xdq87 147 27 outbreak outbreak NN cord-305956-l02xdq87 147 28 in in IN cord-305956-l02xdq87 147 29 China China NNP cord-305956-l02xdq87 147 30 Clinical clinical JJ cord-305956-l02xdq87 147 31 findings finding NNS cord-305956-l02xdq87 147 32 in in IN cord-305956-l02xdq87 147 33 a a DT cord-305956-l02xdq87 147 34 group group NN cord-305956-l02xdq87 147 35 of of IN cord-305956-l02xdq87 147 36 patients patient NNS cord-305956-l02xdq87 147 37 infected infect VBN cord-305956-l02xdq87 147 38 with with IN cord-305956-l02xdq87 147 39 the the DT cord-305956-l02xdq87 147 40 2019 2019 CD cord-305956-l02xdq87 147 41 novel novel NN cord-305956-l02xdq87 147 42 coronavirus coronavirus NN cord-305956-l02xdq87 147 43 ( ( -LRB- cord-305956-l02xdq87 147 44 SARS SARS NNP cord-305956-l02xdq87 147 45 - - HYPH cord-305956-l02xdq87 147 46 Cov-2 Cov-2 NNP cord-305956-l02xdq87 147 47 ) ) -RRB- cord-305956-l02xdq87 147 48 outside outside IN cord-305956-l02xdq87 147 49 of of IN cord-305956-l02xdq87 147 50 Wuhan Wuhan NNP cord-305956-l02xdq87 147 51 , , , cord-305956-l02xdq87 147 52 China China NNP cord-305956-l02xdq87 147 53 : : : cord-305956-l02xdq87 148 1 Retrospective retrospective JJ cord-305956-l02xdq87 148 2 case case NN cord-305956-l02xdq87 148 3 series series NN cord-305956-l02xdq87 148 4 Clinical clinical JJ cord-305956-l02xdq87 148 5 characteristics characteristic NNS cord-305956-l02xdq87 148 6 of of IN cord-305956-l02xdq87 148 7 138 138 CD cord-305956-l02xdq87 148 8 hospitalized hospitalize VBN cord-305956-l02xdq87 148 9 patients patient NNS cord-305956-l02xdq87 148 10 with with IN cord-305956-l02xdq87 148 11 2019 2019 CD cord-305956-l02xdq87 148 12 novel novel JJ cord-305956-l02xdq87 148 13 coronavirusinfected coronavirusinfecte VBN cord-305956-l02xdq87 148 14 pneumonia pneumonia NN cord-305956-l02xdq87 148 15 in in IN cord-305956-l02xdq87 148 16 Wuhan Wuhan NNP cord-305956-l02xdq87 148 17 , , , cord-305956-l02xdq87 149 1 China China NNP cord-305956-l02xdq87 149 2 Radiological radiological JJ cord-305956-l02xdq87 149 3 findings finding NNS cord-305956-l02xdq87 149 4 from from IN cord-305956-l02xdq87 149 5 81 81 CD cord-305956-l02xdq87 149 6 patients patient NNS cord-305956-l02xdq87 149 7 with with IN cord-305956-l02xdq87 149 8 COVID-19 covid-19 JJ cord-305956-l02xdq87 149 9 pneumonia pneumonia NN cord-305956-l02xdq87 149 10 in in IN cord-305956-l02xdq87 149 11 Wuhan Wuhan NNP cord-305956-l02xdq87 149 12 , , , cord-305956-l02xdq87 149 13 China China NNP cord-305956-l02xdq87 149 14 : : : cord-305956-l02xdq87 150 1 A a DT cord-305956-l02xdq87 150 2 descriptive descriptive JJ cord-305956-l02xdq87 150 3 study study NN cord-305956-l02xdq87 150 4 Clinical clinical JJ cord-305956-l02xdq87 150 5 characteristics characteristic NNS cord-305956-l02xdq87 150 6 of of IN cord-305956-l02xdq87 150 7 36 36 CD cord-305956-l02xdq87 150 8 non non NNS cord-305956-l02xdq87 150 9 - - NNS cord-305956-l02xdq87 150 10 survivors survivor NNS cord-305956-l02xdq87 150 11 with with IN cord-305956-l02xdq87 150 12 COVID-19 covid-19 CD cord-305956-l02xdq87 150 13 in in IN cord-305956-l02xdq87 150 14 Wuhan Wuhan NNP cord-305956-l02xdq87 150 15 Clinical clinical JJ cord-305956-l02xdq87 150 16 characteristics characteristic NNS cord-305956-l02xdq87 150 17 of of IN cord-305956-l02xdq87 150 18 coronavirus coronavirus NN cord-305956-l02xdq87 150 19 disease disease NN cord-305956-l02xdq87 150 20 2019 2019 CD cord-305956-l02xdq87 150 21 in in IN cord-305956-l02xdq87 150 22 China China NNP cord-305956-l02xdq87 150 23 COVID-19 covid-19 VBP cord-305956-l02xdq87 150 24 in in IN cord-305956-l02xdq87 150 25 a a DT cord-305956-l02xdq87 150 26 designated designate VBN cord-305956-l02xdq87 150 27 infectious infectious JJ cord-305956-l02xdq87 150 28 diseases disease NNS cord-305956-l02xdq87 150 29 hospital hospital NN cord-305956-l02xdq87 150 30 outside outside IN cord-305956-l02xdq87 150 31 Hubei Hubei NNP cord-305956-l02xdq87 150 32 Province Province NNP cord-305956-l02xdq87 150 33 Clinical Clinical NNP cord-305956-l02xdq87 150 34 features feature NNS cord-305956-l02xdq87 150 35 and and CC cord-305956-l02xdq87 150 36 laboratory laboratory NN cord-305956-l02xdq87 150 37 inspection inspection NN cord-305956-l02xdq87 150 38 of of IN cord-305956-l02xdq87 150 39 novel novel JJ cord-305956-l02xdq87 150 40 coronavirus coronavirus NN cord-305956-l02xdq87 150 41 pneumonia pneumonia NN cord-305956-l02xdq87 150 42 ( ( -LRB- cord-305956-l02xdq87 150 43 COVID-19 COVID-19 NNP cord-305956-l02xdq87 150 44 COVID-19 COVID-19 NNP cord-305956-l02xdq87 150 45 and and CC cord-305956-l02xdq87 150 46 the the DT cord-305956-l02xdq87 150 47 liver liver NN cord-305956-l02xdq87 150 48 : : : cord-305956-l02xdq87 150 49 Little little JJ cord-305956-l02xdq87 150 50 cause cause NN cord-305956-l02xdq87 150 51 for for IN cord-305956-l02xdq87 150 52 concern concern NN cord-305956-l02xdq87 150 53 Perioperative Perioperative NNP cord-305956-l02xdq87 150 54 presentation presentation NN cord-305956-l02xdq87 150 55 of of IN cord-305956-l02xdq87 150 56 COVID-19 COVID-19 NNP cord-305956-l02xdq87 150 57 disease disease NN cord-305956-l02xdq87 150 58 in in IN cord-305956-l02xdq87 150 59 a a DT cord-305956-l02xdq87 150 60 liver liver NN cord-305956-l02xdq87 150 61 transplant transplant NN cord-305956-l02xdq87 150 62 recipient recipient NN cord-305956-l02xdq87 150 63 . . . cord-305956-l02xdq87 151 1 Hepatology Hepatology NNP cord-305956-l02xdq87 151 2 2020 2020 CD cord-305956-l02xdq87 151 3 . . . cord-305956-l02xdq87 152 1 Epub Epub NNP cord-305956-l02xdq87 152 2 ahead ahead RB cord-305956-l02xdq87 152 3 of of IN cord-305956-l02xdq87 152 4 print print NN cord-305956-l02xdq87 152 5 27 27 CD cord-305956-l02xdq87 152 6 Clinical clinical JJ cord-305956-l02xdq87 152 7 characteristics characteristic NNS cord-305956-l02xdq87 152 8 of of IN cord-305956-l02xdq87 152 9 non non JJ cord-305956-l02xdq87 152 10 - - JJ cord-305956-l02xdq87 152 11 ICU ICU NNP cord-305956-l02xdq87 152 12 hospitalized hospitalize VBD cord-305956-l02xdq87 152 13 patients patient NNS cord-305956-l02xdq87 152 14 with with IN cord-305956-l02xdq87 152 15 coronavirus coronavirus NN cord-305956-l02xdq87 152 16 disease disease NN cord-305956-l02xdq87 152 17 2019 2019 CD cord-305956-l02xdq87 152 18 and and CC cord-305956-l02xdq87 152 19 liver liver NN cord-305956-l02xdq87 152 20 injury injury NN cord-305956-l02xdq87 152 21 . . . cord-305956-l02xdq87 153 1 A a DT cord-305956-l02xdq87 153 2 retrospective retrospective JJ cord-305956-l02xdq87 153 3 study study NN cord-305956-l02xdq87 153 4 Liver liver NN cord-305956-l02xdq87 153 5 impairment impairment NN cord-305956-l02xdq87 153 6 in in IN cord-305956-l02xdq87 153 7 COVID-19 covid-19 JJ cord-305956-l02xdq87 153 8 patients patient NNS cord-305956-l02xdq87 153 9 : : : cord-305956-l02xdq87 153 10 A a DT cord-305956-l02xdq87 153 11 retrospective retrospective JJ cord-305956-l02xdq87 153 12 analysis analysis NN cord-305956-l02xdq87 153 13 of of IN cord-305956-l02xdq87 153 14 115 115 CD cord-305956-l02xdq87 153 15 cases case NNS cord-305956-l02xdq87 153 16 from from IN cord-305956-l02xdq87 153 17 a a DT cord-305956-l02xdq87 153 18 single single JJ cord-305956-l02xdq87 153 19 center center NN cord-305956-l02xdq87 153 20 in in IN cord-305956-l02xdq87 153 21 Wuhan Wuhan NNP cord-305956-l02xdq87 153 22 city city NN cord-305956-l02xdq87 153 23 , , , cord-305956-l02xdq87 153 24 China China NNP cord-305956-l02xdq87 153 25 . . . cord-305956-l02xdq87 154 1 Liver liver NN cord-305956-l02xdq87 154 2 Int Int NNP cord-305956-l02xdq87 154 3 2020 2020 CD cord-305956-l02xdq87 154 4 . . . cord-305956-l02xdq87 155 1 Epub Epub NNP cord-305956-l02xdq87 155 2 ahead ahead RB cord-305956-l02xdq87 155 3 of of IN cord-305956-l02xdq87 155 4 print print NN cord-305956-l02xdq87 155 5 2 2 CD cord-305956-l02xdq87 156 1 The the DT cord-305956-l02xdq87 156 2 clinical clinical JJ cord-305956-l02xdq87 156 3 characteristics characteristic NNS cord-305956-l02xdq87 156 4 of of IN cord-305956-l02xdq87 156 5 pneumonia pneumonia NN cord-305956-l02xdq87 156 6 patients patient NNS cord-305956-l02xdq87 156 7 coinfected coinfecte VBD cord-305956-l02xdq87 156 8 with with IN cord-305956-l02xdq87 156 9 2019 2019 CD cord-305956-l02xdq87 156 10 novel novel JJ cord-305956-l02xdq87 156 11 coronavirus coronavirus NN cord-305956-l02xdq87 156 12 and and CC cord-305956-l02xdq87 156 13 influenza influenza NN cord-305956-l02xdq87 156 14 virus virus NN cord-305956-l02xdq87 156 15 in in IN cord-305956-l02xdq87 156 16 Wuhan Wuhan NNP cord-305956-l02xdq87 156 17 A A NNP cord-305956-l02xdq87 156 18 comparative comparative JJ cord-305956-l02xdq87 156 19 study study NN cord-305956-l02xdq87 156 20 on on IN cord-305956-l02xdq87 156 21 the the DT cord-305956-l02xdq87 156 22 clinical clinical JJ cord-305956-l02xdq87 156 23 features feature NNS cord-305956-l02xdq87 156 24 of of IN cord-305956-l02xdq87 156 25 COVID-19 covid-19 JJ cord-305956-l02xdq87 156 26 pneumonia pneumonia NN cord-305956-l02xdq87 156 27 to to IN cord-305956-l02xdq87 156 28 other other JJ cord-305956-l02xdq87 156 29 pneumonias pneumonia NNS cord-305956-l02xdq87 156 30 COVID-19 covid-19 VBP cord-305956-l02xdq87 156 31 and and CC cord-305956-l02xdq87 156 32 liver liver NN cord-305956-l02xdq87 156 33 dysfunction dysfunction NN cord-305956-l02xdq87 156 34 : : : cord-305956-l02xdq87 156 35 Current current JJ cord-305956-l02xdq87 156 36 insights insight NNS cord-305956-l02xdq87 156 37 and and CC cord-305956-l02xdq87 156 38 emergent emergent JJ cord-305956-l02xdq87 156 39 therapeutic therapeutic JJ cord-305956-l02xdq87 156 40 strategies strategy NNS cord-305956-l02xdq87 156 41 Clinical clinical JJ cord-305956-l02xdq87 156 42 characteristics characteristic NNS cord-305956-l02xdq87 156 43 and and CC cord-305956-l02xdq87 156 44 intrauterine intrauterine JJ cord-305956-l02xdq87 156 45 vertical vertical JJ cord-305956-l02xdq87 156 46 transmission transmission NN cord-305956-l02xdq87 156 47 potential potential NN cord-305956-l02xdq87 156 48 of of IN cord-305956-l02xdq87 156 49 COVID-19 covid-19 JJ cord-305956-l02xdq87 156 50 infection infection NN cord-305956-l02xdq87 156 51 in in IN cord-305956-l02xdq87 156 52 nine nine CD cord-305956-l02xdq87 156 53 pregnant pregnant JJ cord-305956-l02xdq87 156 54 women woman NNS cord-305956-l02xdq87 156 55 : : : cord-305956-l02xdq87 156 56 A a DT cord-305956-l02xdq87 156 57 retrospective retrospective JJ cord-305956-l02xdq87 156 58 review review NN cord-305956-l02xdq87 156 59 of of IN cord-305956-l02xdq87 156 60 medical medical JJ cord-305956-l02xdq87 156 61 records record NNS cord-305956-l02xdq87 156 62 Time Time NNP cord-305956-l02xdq87 156 63 course course NN cord-305956-l02xdq87 156 64 of of IN cord-305956-l02xdq87 156 65 lung lung NN cord-305956-l02xdq87 156 66 changes change NNS cord-305956-l02xdq87 156 67 on on IN cord-305956-l02xdq87 156 68 chest chest NN cord-305956-l02xdq87 156 69 CT CT NNP cord-305956-l02xdq87 156 70 during during IN cord-305956-l02xdq87 156 71 recovery recovery NN cord-305956-l02xdq87 156 72 from from IN cord-305956-l02xdq87 156 73 2019 2019 CD cord-305956-l02xdq87 156 74 novel novel JJ cord-305956-l02xdq87 156 75 coronavirus coronavirus NN cord-305956-l02xdq87 156 76 ( ( -LRB- cord-305956-l02xdq87 156 77 COVID-19 COVID-19 NNP cord-305956-l02xdq87 156 78 ) ) -RRB- cord-305956-l02xdq87 156 79 pneumonia pneumonia NN cord-305956-l02xdq87 156 80 . . . cord-305956-l02xdq87 157 1 Radiology Radiology NNP cord-305956-l02xdq87 157 2 Epub Epub NNP cord-305956-l02xdq87 157 3 ahead ahead RB cord-305956-l02xdq87 157 4 of of IN cord-305956-l02xdq87 157 5 print print NN cord-305956-l02xdq87 157 6 Bethesda Bethesda NNP cord-305956-l02xdq87 157 7 ( ( -LRB- cord-305956-l02xdq87 157 8 MD MD NNP cord-305956-l02xdq87 157 9 ) ) -RRB- cord-305956-l02xdq87 157 10 : : : cord-305956-l02xdq87 157 11 National National NNP cord-305956-l02xdq87 157 12 Institute Institute NNP cord-305956-l02xdq87 157 13 of of IN cord-305956-l02xdq87 157 14 Diabetes Diabetes NNP cord-305956-l02xdq87 157 15 and and CC cord-305956-l02xdq87 157 16 Digestive digestive JJ cord-305956-l02xdq87 157 17 and and CC cord-305956-l02xdq87 157 18 Kidney kidney NN cord-305956-l02xdq87 157 19 Diseases disease NNS cord-305956-l02xdq87 158 1 Clinical clinical JJ cord-305956-l02xdq87 158 2 , , , cord-305956-l02xdq87 158 3 laboratory laboratory NN cord-305956-l02xdq87 158 4 and and CC cord-305956-l02xdq87 158 5 imaging imaging NN cord-305956-l02xdq87 158 6 features feature NNS cord-305956-l02xdq87 158 7 of of IN cord-305956-l02xdq87 158 8 COVID-19 covid-19 NN cord-305956-l02xdq87 158 9 : : : cord-305956-l02xdq87 158 10 A a DT cord-305956-l02xdq87 158 11 systematic systematic JJ cord-305956-l02xdq87 158 12 review review NN cord-305956-l02xdq87 158 13 and and CC cord-305956-l02xdq87 158 14 metaanalysis metaanalysis NN cord-305956-l02xdq87 158 15 Clinical clinical JJ cord-305956-l02xdq87 158 16 manifestations manifestation NNS cord-305956-l02xdq87 158 17 , , , cord-305956-l02xdq87 158 18 laboratory laboratory NN cord-305956-l02xdq87 158 19 findings finding NNS cord-305956-l02xdq87 158 20 , , , cord-305956-l02xdq87 158 21 and and CC cord-305956-l02xdq87 158 22 treatment treatment NN cord-305956-l02xdq87 158 23 outcomes outcome NNS cord-305956-l02xdq87 158 24 of of IN cord-305956-l02xdq87 158 25 SARS SARS NNP cord-305956-l02xdq87 158 26 patients patient NNS cord-305956-l02xdq87 158 27 Systemic systemic JJ cord-305956-l02xdq87 158 28 viral viral JJ cord-305956-l02xdq87 158 29 infections infection NNS cord-305956-l02xdq87 158 30 and and CC cord-305956-l02xdq87 158 31 collateral collateral JJ cord-305956-l02xdq87 158 32 damage damage NN cord-305956-l02xdq87 158 33 in in IN cord-305956-l02xdq87 158 34 the the DT cord-305956-l02xdq87 158 35 liver liver NN cord-305956-l02xdq87 159 1 A a DT cord-305956-l02xdq87 159 2 trial trial NN cord-305956-l02xdq87 159 3 of of IN cord-305956-l02xdq87 159 4 lopinavir lopinavir NNS cord-305956-l02xdq87 159 5 - - HYPH cord-305956-l02xdq87 159 6 ritonavir ritonavir NNS cord-305956-l02xdq87 159 7 in in IN cord-305956-l02xdq87 159 8 adults adult NNS cord-305956-l02xdq87 159 9 hospitalized hospitalize VBN cord-305956-l02xdq87 159 10 with with IN cord-305956-l02xdq87 159 11 severe severe JJ cord-305956-l02xdq87 159 12 Covid-19 covid-19 NN cord-305956-l02xdq87 159 13 Breakthrough Breakthrough NNP cord-305956-l02xdq87 160 1 : : : cord-305956-l02xdq87 160 2 Chloroquine chloroquine NN cord-305956-l02xdq87 160 3 phosphate phosphate NN cord-305956-l02xdq87 160 4 has have VBZ cord-305956-l02xdq87 160 5 shown show VBN cord-305956-l02xdq87 160 6 apparent apparent JJ cord-305956-l02xdq87 160 7 efficacy efficacy NN cord-305956-l02xdq87 160 8 in in IN cord-305956-l02xdq87 160 9 treatment treatment NN cord-305956-l02xdq87 160 10 of of IN cord-305956-l02xdq87 160 11 COVID-19 covid-19 JJ cord-305956-l02xdq87 160 12 associated associated JJ cord-305956-l02xdq87 160 13 pneumonia pneumonia NN cord-305956-l02xdq87 160 14 in in IN cord-305956-l02xdq87 160 15 clinical clinical JJ cord-305956-l02xdq87 160 16 studies study NNS cord-305956-l02xdq87 160 17 Insights insight NNS cord-305956-l02xdq87 160 18 from from IN cord-305956-l02xdq87 160 19 nanomedicine nanomedicine NN cord-305956-l02xdq87 160 20 into into IN cord-305956-l02xdq87 160 21 chloroquine chloroquine JJ cord-305956-l02xdq87 160 22 efficacy efficacy NN cord-305956-l02xdq87 160 23 against against IN cord-305956-l02xdq87 160 24 COVID-19 COVID-19 NNP cord-305956-l02xdq87 160 25 Prophylactic prophylactic JJ cord-305956-l02xdq87 160 26 and and CC cord-305956-l02xdq87 160 27 therapeutic therapeutic JJ cord-305956-l02xdq87 160 28 remdesivir remdesivir NNS cord-305956-l02xdq87 160 29 ( ( -LRB- cord-305956-l02xdq87 160 30 GS-5734 GS-5734 NNP cord-305956-l02xdq87 160 31 ) ) -RRB- cord-305956-l02xdq87 160 32 treatment treatment NN cord-305956-l02xdq87 160 33 in in IN cord-305956-l02xdq87 160 34 the the DT cord-305956-l02xdq87 160 35 rhesus rhesus NNP cord-305956-l02xdq87 160 36 macaque macaque NN cord-305956-l02xdq87 160 37 model model NN cord-305956-l02xdq87 160 38 of of IN cord-305956-l02xdq87 160 39 MERS MERS NNP cord-305956-l02xdq87 160 40 - - HYPH cord-305956-l02xdq87 160 41 CoV CoV NNP cord-305956-l02xdq87 160 42 infection infection NN cord-305956-l02xdq87 160 43 Clinical clinical JJ cord-305956-l02xdq87 160 44 progression progression NN cord-305956-l02xdq87 160 45 and and CC cord-305956-l02xdq87 160 46 viral viral JJ cord-305956-l02xdq87 160 47 load load NN cord-305956-l02xdq87 160 48 in in IN cord-305956-l02xdq87 160 49 a a DT cord-305956-l02xdq87 160 50 community community NN cord-305956-l02xdq87 160 51 outbreak outbreak NN cord-305956-l02xdq87 160 52 of of IN cord-305956-l02xdq87 160 53 coronavirusassociated coronavirusassociate VBN cord-305956-l02xdq87 160 54 SARS SARS NNP cord-305956-l02xdq87 160 55 pneumonia pneumonia NN cord-305956-l02xdq87 160 56 : : : cord-305956-l02xdq87 161 1 A a DT cord-305956-l02xdq87 161 2 prospective prospective JJ cord-305956-l02xdq87 161 3 study study NN cord-305956-l02xdq87 161 4 Care care NN cord-305956-l02xdq87 161 5 of of IN cord-305956-l02xdq87 161 6 patients patient NNS cord-305956-l02xdq87 161 7 with with IN cord-305956-l02xdq87 161 8 liver liver NN cord-305956-l02xdq87 161 9 disease disease NN cord-305956-l02xdq87 161 10 during during IN cord-305956-l02xdq87 161 11 the the DT cord-305956-l02xdq87 161 12 COVID-19 COVID-19 NNP cord-305956-l02xdq87 161 13 pandemic pandemic NN cord-305956-l02xdq87 162 1 : : : cord-305956-l02xdq87 162 2 EASL EASL NNP cord-305956-l02xdq87 162 3 - - HYPH cord-305956-l02xdq87 162 4 ESCMID ESCMID NNP cord-305956-l02xdq87 162 5 position position NN cord-305956-l02xdq87 162 6 paper paper NN cord-305956-l02xdq87 163 1 The the DT cord-305956-l02xdq87 163 2 authors author NNS cord-305956-l02xdq87 163 3 received receive VBD cord-305956-l02xdq87 163 4 no no DT cord-305956-l02xdq87 163 5 financial financial JJ cord-305956-l02xdq87 163 6 support support NN cord-305956-l02xdq87 163 7 for for IN cord-305956-l02xdq87 163 8 the the DT cord-305956-l02xdq87 163 9 research research NN cord-305956-l02xdq87 163 10 , , , cord-305956-l02xdq87 163 11 authorship authorship NN cord-305956-l02xdq87 163 12 , , , cord-305956-l02xdq87 163 13 and/or and/or CC cord-305956-l02xdq87 163 14 publication publication NN cord-305956-l02xdq87 163 15 of of IN cord-305956-l02xdq87 163 16 this this DT cord-305956-l02xdq87 163 17 article article NN cord-305956-l02xdq87 163 18 . . . cord-305956-l02xdq87 164 1 J€ J€ NNP cord-305956-l02xdq87 164 2 orn orn NN cord-305956-l02xdq87 164 3 M M NNP cord-305956-l02xdq87 164 4 Schattenberg Schattenberg NNP cord-305956-l02xdq87 164 5 https://orcid.org/0000-0002-4224-4703 https://orcid.org/0000-0002-4224-4703 NNP