id sid tid token lemma pos cord-302756-343y63e5 1 1 key key JJ cord-302756-343y63e5 1 2 : : : cord-302756-343y63e5 1 3 cord-302756 cord-302756 NNP cord-302756-343y63e5 1 4 - - HYPH cord-302756-343y63e5 1 5 343y63e5 343y63e5 CD cord-302756-343y63e5 1 6 authors author NNS cord-302756-343y63e5 1 7 : : : cord-302756-343y63e5 1 8 Thachil Thachil NNP cord-302756-343y63e5 1 9 , , , cord-302756-343y63e5 1 10 J J NNP cord-302756-343y63e5 1 11 ; ; : cord-302756-343y63e5 1 12 Agarwal Agarwal NNP cord-302756-343y63e5 1 13 , , , cord-302756-343y63e5 1 14 S. S. NNP cord-302756-343y63e5 1 15 title title NN cord-302756-343y63e5 1 16 : : : cord-302756-343y63e5 1 17 Understanding understand VBG cord-302756-343y63e5 1 18 the the DT cord-302756-343y63e5 1 19 COVID‐19 COVID‐19 NNP cord-302756-343y63e5 1 20 coagulopathy coagulopathy NN cord-302756-343y63e5 1 21 spectrum spectrum NN cord-302756-343y63e5 1 22 date date NN cord-302756-343y63e5 1 23 : : : cord-302756-343y63e5 1 24 2020 2020 CD cord-302756-343y63e5 1 25 - - HYPH cord-302756-343y63e5 1 26 05 05 CD cord-302756-343y63e5 1 27 - - SYM cord-302756-343y63e5 1 28 21 21 CD cord-302756-343y63e5 1 29 journal journal NN cord-302756-343y63e5 1 30 : : : cord-302756-343y63e5 2 1 Anaesthesia anaesthesia NN cord-302756-343y63e5 2 2 DOI DOI NNP cord-302756-343y63e5 2 3 : : : cord-302756-343y63e5 3 1 10.1111 10.1111 CD cord-302756-343y63e5 3 2 / / SYM cord-302756-343y63e5 3 3 anae.15141 anae.15141 NNP cord-302756-343y63e5 3 4 sha sha NNP cord-302756-343y63e5 3 5 : : : cord-302756-343y63e5 4 1 8c23b2b5075114118d470e0912e09e0ff3fccb0c 8c23b2b5075114118d470e0912e09e0ff3fccb0c CD cord-302756-343y63e5 4 2 doc_id doc_id CD cord-302756-343y63e5 4 3 : : : cord-302756-343y63e5 4 4 302756 302756 CD cord-302756-343y63e5 4 5 cord_uid cord_uid NNS cord-302756-343y63e5 4 6 : : : cord-302756-343y63e5 4 7 343y63e5 343y63e5 CD cord-302756-343y63e5 5 1 The the DT cord-302756-343y63e5 5 2 SARS‐Cov‐2 SARS‐Cov‐2 NNS cord-302756-343y63e5 5 3 ( ( -LRB- cord-302756-343y63e5 5 4 COVID‐19 covid‐19 NN cord-302756-343y63e5 5 5 ) ) -RRB- cord-302756-343y63e5 5 6 pandemic pandemic NN cord-302756-343y63e5 5 7 has have VBZ cord-302756-343y63e5 5 8 already already RB cord-302756-343y63e5 5 9 claimed claim VBN cord-302756-343y63e5 5 10 over over IN cord-302756-343y63e5 5 11 200,000 200,000 CD cord-302756-343y63e5 5 12 lives life NNS cord-302756-343y63e5 5 13 . . . cord-302756-343y63e5 6 1 Quite quite RB cord-302756-343y63e5 6 2 early early RB cord-302756-343y63e5 6 3 on on RB cord-302756-343y63e5 6 4 in in IN cord-302756-343y63e5 6 5 this this DT cord-302756-343y63e5 6 6 pandemic pandemic NN cord-302756-343y63e5 6 7 , , , cord-302756-343y63e5 6 8 it -PRON- PRP cord-302756-343y63e5 6 9 was be VBD cord-302756-343y63e5 6 10 recognised recognise VBN cord-302756-343y63e5 6 11 that that IN cord-302756-343y63e5 6 12 the the DT cord-302756-343y63e5 6 13 virus virus NN cord-302756-343y63e5 6 14 triggers trigger VBZ cord-302756-343y63e5 6 15 the the DT cord-302756-343y63e5 6 16 immune immune JJ cord-302756-343y63e5 6 17 system system NN cord-302756-343y63e5 6 18 leading lead VBG cord-302756-343y63e5 6 19 to to IN cord-302756-343y63e5 6 20 a a DT cord-302756-343y63e5 6 21 cytokine cytokine NN cord-302756-343y63e5 6 22 storm storm NN cord-302756-343y63e5 6 23 in in IN cord-302756-343y63e5 6 24 some some DT cord-302756-343y63e5 6 25 severely severely RB cord-302756-343y63e5 6 26 ill ill JJ cord-302756-343y63e5 6 27 patients patient NNS cord-302756-343y63e5 6 28 [ [ -LRB- cord-302756-343y63e5 6 29 1 1 CD cord-302756-343y63e5 6 30 ] ] -RRB- cord-302756-343y63e5 6 31 . . . cord-302756-343y63e5 7 1 This this DT cord-302756-343y63e5 7 2 hyper‐responsiveness hyper‐responsiveness NN cord-302756-343y63e5 7 3 has have VBZ cord-302756-343y63e5 7 4 been be VBN cord-302756-343y63e5 7 5 suggested suggest VBN cord-302756-343y63e5 7 6 to to TO cord-302756-343y63e5 7 7 be be VB cord-302756-343y63e5 7 8 the the DT cord-302756-343y63e5 7 9 predominant predominant JJ cord-302756-343y63e5 7 10 aetiology aetiology NN cord-302756-343y63e5 7 11 for for IN cord-302756-343y63e5 7 12 clinical clinical JJ cord-302756-343y63e5 7 13 deterioration deterioration NN cord-302756-343y63e5 7 14 and and CC cord-302756-343y63e5 7 15 mortality mortality NN cord-302756-343y63e5 7 16 in in IN cord-302756-343y63e5 7 17 patients patient NNS cord-302756-343y63e5 7 18 with with IN cord-302756-343y63e5 7 19 this this DT cord-302756-343y63e5 7 20 infection infection NN cord-302756-343y63e5 7 21 [ [ -LRB- cord-302756-343y63e5 7 22 2 2 CD cord-302756-343y63e5 7 23 ] ] -RRB- cord-302756-343y63e5 7 24 . . . cord-302756-343y63e5 8 1 More more RBR cord-302756-343y63e5 8 2 recently recently RB cord-302756-343y63e5 8 3 , , , cord-302756-343y63e5 8 4 there there EX cord-302756-343y63e5 8 5 have have VBP cord-302756-343y63e5 8 6 been be VBN cord-302756-343y63e5 8 7 several several JJ cord-302756-343y63e5 8 8 reports report NNS cord-302756-343y63e5 8 9 of of IN cord-302756-343y63e5 8 10 increased increase VBN cord-302756-343y63e5 8 11 thrombotic thrombotic JJ cord-302756-343y63e5 8 12 events event NNS cord-302756-343y63e5 8 13 in in IN cord-302756-343y63e5 8 14 these these DT cord-302756-343y63e5 8 15 patients patient NNS cord-302756-343y63e5 8 16 [ [ -LRB- cord-302756-343y63e5 8 17 3‐6 3‐6 CD cord-302756-343y63e5 8 18 ] ] -RRB- cord-302756-343y63e5 8 19 . . . cord-302756-343y63e5 9 1 From from IN cord-302756-343y63e5 9 2 a a DT cord-302756-343y63e5 9 3 laboratory laboratory NN cord-302756-343y63e5 9 4 perspective perspective NN cord-302756-343y63e5 9 5 , , , cord-302756-343y63e5 9 6 this this DT cord-302756-343y63e5 9 7 hypercoagulability hypercoagulability NN cord-302756-343y63e5 9 8 is be VBZ cord-302756-343y63e5 9 9 reflected reflect VBN cord-302756-343y63e5 9 10 in in IN cord-302756-343y63e5 9 11 the the DT cord-302756-343y63e5 9 12 marked marked JJ cord-302756-343y63e5 9 13 elevation elevation NN cord-302756-343y63e5 9 14 of of IN cord-302756-343y63e5 9 15 the the DT cord-302756-343y63e5 9 16 fibrinolytic fibrinolytic JJ cord-302756-343y63e5 9 17 marker marker NN cord-302756-343y63e5 9 18 , , , cord-302756-343y63e5 9 19 D‐dimer D‐dimer NNP cord-302756-343y63e5 9 20 , , , cord-302756-343y63e5 9 21 in in IN cord-302756-343y63e5 9 22 almost almost RB cord-302756-343y63e5 9 23 all all DT cord-302756-343y63e5 9 24 hospitalised hospitalise VBN cord-302756-343y63e5 9 25 COVID‐19 COVID‐19 NNP cord-302756-343y63e5 9 26 patients patient NNS cord-302756-343y63e5 9 27 [ [ -LRB- cord-302756-343y63e5 9 28 7 7 CD cord-302756-343y63e5 9 29 ] ] -RRB- cord-302756-343y63e5 9 30 . . . cord-302756-343y63e5 10 1 We -PRON- PRP cord-302756-343y63e5 10 2 must must MD cord-302756-343y63e5 10 3 , , , cord-302756-343y63e5 10 4 therefore therefore RB cord-302756-343y63e5 10 5 , , , cord-302756-343y63e5 10 6 ask ask VB cord-302756-343y63e5 10 7 ourselves -PRON- PRP cord-302756-343y63e5 10 8 what what WP cord-302756-343y63e5 10 9 is be VBZ cord-302756-343y63e5 10 10 the the DT cord-302756-343y63e5 10 11 link link NN cord-302756-343y63e5 10 12 between between IN cord-302756-343y63e5 10 13 the the DT cord-302756-343y63e5 10 14 extremes extreme NNS cord-302756-343y63e5 10 15 of of IN cord-302756-343y63e5 10 16 the the DT cord-302756-343y63e5 10 17 immune immune JJ cord-302756-343y63e5 10 18 system system NN cord-302756-343y63e5 10 19 , , , cord-302756-343y63e5 10 20 presenting present VBG cord-302756-343y63e5 10 21 as as IN cord-302756-343y63e5 10 22 cytokine cytokine NN cord-302756-343y63e5 10 23 storm storm NN cord-302756-343y63e5 10 24 , , , cord-302756-343y63e5 10 25 and and CC cord-302756-343y63e5 10 26 the the DT cord-302756-343y63e5 10 27 extremes extreme NNS cord-302756-343y63e5 10 28 of of IN cord-302756-343y63e5 10 29 coagulation coagulation NN cord-302756-343y63e5 10 30 , , , cord-302756-343y63e5 10 31 presenting present VBG cord-302756-343y63e5 10 32 as as IN cord-302756-343y63e5 10 33 arterial arterial JJ cord-302756-343y63e5 10 34 and and CC cord-302756-343y63e5 10 35 venous venous JJ cord-302756-343y63e5 10 36 thromboembolism thromboembolism NN cord-302756-343y63e5 10 37 ? ? . cord-302756-343y63e5 11 1 This this DT cord-302756-343y63e5 11 2 article article NN cord-302756-343y63e5 11 3 is be VBZ cord-302756-343y63e5 11 4 protected protect VBN cord-302756-343y63e5 11 5 by by IN cord-302756-343y63e5 11 6 copyright copyright NN cord-302756-343y63e5 11 7 . . . cord-302756-343y63e5 12 1 All all DT cord-302756-343y63e5 12 2 rights right NNS cord-302756-343y63e5 12 3 reserved reserve VBN cord-302756-343y63e5 13 1 The the DT cord-302756-343y63e5 13 2 SARS SARS NNP cord-302756-343y63e5 13 3 - - HYPH cord-302756-343y63e5 13 4 Cov-2 Cov-2 NNP cord-302756-343y63e5 13 5 ( ( -LRB- cord-302756-343y63e5 13 6 COVID-19 covid-19 VB cord-302756-343y63e5 13 7 ) ) -RRB- cord-302756-343y63e5 13 8 pandemic pandemic NN cord-302756-343y63e5 13 9 has have VBZ cord-302756-343y63e5 13 10 already already RB cord-302756-343y63e5 13 11 claimed claim VBN cord-302756-343y63e5 13 12 over over IN cord-302756-343y63e5 13 13 200,000 200,000 CD cord-302756-343y63e5 13 14 lives life NNS cord-302756-343y63e5 13 15 . . . cord-302756-343y63e5 14 1 Quite quite RB cord-302756-343y63e5 14 2 early early RB cord-302756-343y63e5 14 3 on on RB cord-302756-343y63e5 14 4 in in IN cord-302756-343y63e5 14 5 this this DT cord-302756-343y63e5 14 6 pandemic pandemic NN cord-302756-343y63e5 14 7 , , , cord-302756-343y63e5 14 8 it -PRON- PRP cord-302756-343y63e5 14 9 was be VBD cord-302756-343y63e5 14 10 recognised recognise VBN cord-302756-343y63e5 14 11 that that IN cord-302756-343y63e5 14 12 the the DT cord-302756-343y63e5 14 13 virus virus NN cord-302756-343y63e5 14 14 triggers trigger VBZ cord-302756-343y63e5 14 15 the the DT cord-302756-343y63e5 14 16 immune immune JJ cord-302756-343y63e5 14 17 system system NN cord-302756-343y63e5 14 18 leading lead VBG cord-302756-343y63e5 14 19 to to IN cord-302756-343y63e5 14 20 a a DT cord-302756-343y63e5 14 21 cytokine cytokine NN cord-302756-343y63e5 14 22 storm storm NN cord-302756-343y63e5 14 23 in in IN cord-302756-343y63e5 14 24 some some DT cord-302756-343y63e5 14 25 severely severely RB cord-302756-343y63e5 14 26 ill ill JJ cord-302756-343y63e5 14 27 patients patient NNS cord-302756-343y63e5 14 28 [ [ -LRB- cord-302756-343y63e5 14 29 1 1 CD cord-302756-343y63e5 14 30 ] ] -RRB- cord-302756-343y63e5 14 31 . . . cord-302756-343y63e5 15 1 This this DT cord-302756-343y63e5 15 2 hyper hyper JJ cord-302756-343y63e5 15 3 - - NN cord-302756-343y63e5 15 4 responsiveness responsiveness NN cord-302756-343y63e5 15 5 has have VBZ cord-302756-343y63e5 15 6 been be VBN cord-302756-343y63e5 15 7 suggested suggest VBN cord-302756-343y63e5 15 8 to to TO cord-302756-343y63e5 15 9 be be VB cord-302756-343y63e5 15 10 the the DT cord-302756-343y63e5 15 11 predominant predominant JJ cord-302756-343y63e5 15 12 aetiology aetiology NN cord-302756-343y63e5 15 13 for for IN cord-302756-343y63e5 15 14 clinical clinical JJ cord-302756-343y63e5 15 15 deterioration deterioration NN cord-302756-343y63e5 15 16 and and CC cord-302756-343y63e5 15 17 mortality mortality NN cord-302756-343y63e5 15 18 in in IN cord-302756-343y63e5 15 19 patients patient NNS cord-302756-343y63e5 15 20 with with IN cord-302756-343y63e5 15 21 this this DT cord-302756-343y63e5 15 22 infection infection NN cord-302756-343y63e5 15 23 [ [ -LRB- cord-302756-343y63e5 15 24 2 2 CD cord-302756-343y63e5 15 25 ] ] -RRB- cord-302756-343y63e5 15 26 . . . cord-302756-343y63e5 16 1 More more RBR cord-302756-343y63e5 16 2 recently recently RB cord-302756-343y63e5 16 3 , , , cord-302756-343y63e5 16 4 there there EX cord-302756-343y63e5 16 5 have have VBP cord-302756-343y63e5 16 6 been be VBN cord-302756-343y63e5 16 7 several several JJ cord-302756-343y63e5 16 8 reports report NNS cord-302756-343y63e5 16 9 of of IN cord-302756-343y63e5 16 10 increased increase VBN cord-302756-343y63e5 16 11 thrombotic thrombotic JJ cord-302756-343y63e5 16 12 events event NNS cord-302756-343y63e5 16 13 in in IN cord-302756-343y63e5 16 14 these these DT cord-302756-343y63e5 16 15 patients patient NNS cord-302756-343y63e5 16 16 [ [ -LRB- cord-302756-343y63e5 16 17 3 3 CD cord-302756-343y63e5 16 18 ] ] -RRB- cord-302756-343y63e5 16 19 [ [ -LRB- cord-302756-343y63e5 16 20 4 4 CD cord-302756-343y63e5 16 21 ] ] -RRB- cord-302756-343y63e5 16 22 [ [ -LRB- cord-302756-343y63e5 16 23 5 5 CD cord-302756-343y63e5 16 24 ] ] -RRB- cord-302756-343y63e5 16 25 [ [ -LRB- cord-302756-343y63e5 16 26 6 6 CD cord-302756-343y63e5 16 27 ] ] -RRB- cord-302756-343y63e5 16 28 . . . cord-302756-343y63e5 17 1 From from IN cord-302756-343y63e5 17 2 a a DT cord-302756-343y63e5 17 3 laboratory laboratory NN cord-302756-343y63e5 17 4 perspective perspective NN cord-302756-343y63e5 17 5 , , , cord-302756-343y63e5 17 6 this this DT cord-302756-343y63e5 17 7 hypercoagulability hypercoagulability NN cord-302756-343y63e5 17 8 is be VBZ cord-302756-343y63e5 17 9 reflected reflect VBN cord-302756-343y63e5 17 10 in in IN cord-302756-343y63e5 17 11 the the DT cord-302756-343y63e5 17 12 marked marked JJ cord-302756-343y63e5 17 13 elevation elevation NN cord-302756-343y63e5 17 14 of of IN cord-302756-343y63e5 17 15 the the DT cord-302756-343y63e5 17 16 fibrinolytic fibrinolytic JJ cord-302756-343y63e5 17 17 marker marker NN cord-302756-343y63e5 17 18 , , , cord-302756-343y63e5 17 19 D d NN cord-302756-343y63e5 17 20 - - HYPH cord-302756-343y63e5 17 21 dimer dimer NN cord-302756-343y63e5 17 22 , , , cord-302756-343y63e5 17 23 in in IN cord-302756-343y63e5 17 24 almost almost RB cord-302756-343y63e5 17 25 all all DT cord-302756-343y63e5 17 26 hospitalised hospitalise VBN cord-302756-343y63e5 17 27 COVID-19 covid-19 CD cord-302756-343y63e5 17 28 patients patient NNS cord-302756-343y63e5 17 29 [ [ -LRB- cord-302756-343y63e5 17 30 7 7 CD cord-302756-343y63e5 17 31 ] ] -RRB- cord-302756-343y63e5 17 32 . . . cord-302756-343y63e5 18 1 We -PRON- PRP cord-302756-343y63e5 18 2 must must MD cord-302756-343y63e5 18 3 , , , cord-302756-343y63e5 18 4 therefore therefore RB cord-302756-343y63e5 18 5 , , , cord-302756-343y63e5 18 6 ask ask VB cord-302756-343y63e5 18 7 ourselves -PRON- PRP cord-302756-343y63e5 18 8 what what WP cord-302756-343y63e5 18 9 is be VBZ cord-302756-343y63e5 18 10 the the DT cord-302756-343y63e5 18 11 link link NN cord-302756-343y63e5 18 12 between between IN cord-302756-343y63e5 18 13 the the DT cord-302756-343y63e5 18 14 extremes extreme NNS cord-302756-343y63e5 18 15 of of IN cord-302756-343y63e5 18 16 the the DT cord-302756-343y63e5 18 17 immune immune JJ cord-302756-343y63e5 18 18 system system NN cord-302756-343y63e5 18 19 , , , cord-302756-343y63e5 18 20 presenting present VBG cord-302756-343y63e5 18 21 as as IN cord-302756-343y63e5 18 22 cytokine cytokine NN cord-302756-343y63e5 18 23 storm storm NN cord-302756-343y63e5 18 24 , , , cord-302756-343y63e5 18 25 and and CC cord-302756-343y63e5 18 26 the the DT cord-302756-343y63e5 18 27 extremes extreme NNS cord-302756-343y63e5 18 28 of of IN cord-302756-343y63e5 18 29 coagulation coagulation NN cord-302756-343y63e5 18 30 , , , cord-302756-343y63e5 18 31 presenting present VBG cord-302756-343y63e5 18 32 as as IN cord-302756-343y63e5 18 33 arterial arterial JJ cord-302756-343y63e5 18 34 and and CC cord-302756-343y63e5 18 35 venous venous JJ cord-302756-343y63e5 18 36 thromboembolism thromboembolism NN cord-302756-343y63e5 18 37 ? ? . cord-302756-343y63e5 19 1 In in IN cord-302756-343y63e5 19 2 embryological embryological JJ cord-302756-343y63e5 19 3 organisms organism NNS cord-302756-343y63e5 19 4 such such JJ cord-302756-343y63e5 19 5 as as IN cord-302756-343y63e5 19 6 the the DT cord-302756-343y63e5 19 7 horse horse NN cord-302756-343y63e5 19 8 - - HYPH cord-302756-343y63e5 19 9 shoe shoe NN cord-302756-343y63e5 19 10 crab crab NN cord-302756-343y63e5 19 11 , , , cord-302756-343y63e5 19 12 the the DT cord-302756-343y63e5 19 13 haemostatic haemostatic JJ cord-302756-343y63e5 19 14 system system NN cord-302756-343y63e5 19 15 and and CC cord-302756-343y63e5 19 16 the the DT cord-302756-343y63e5 19 17 immune immune JJ cord-302756-343y63e5 19 18 system system NN cord-302756-343y63e5 19 19 were be VBD cord-302756-343y63e5 19 20 one one CD cord-302756-343y63e5 19 21 and and CC cord-302756-343y63e5 19 22 the the DT cord-302756-343y63e5 19 23 same same JJ cord-302756-343y63e5 19 24 ( ( -LRB- cord-302756-343y63e5 19 25 haemolymph haemolymph NN cord-302756-343y63e5 19 26 ) ) -RRB- cord-302756-343y63e5 20 1 [ [ -LRB- cord-302756-343y63e5 20 2 8 8 CD cord-302756-343y63e5 20 3 ] ] -RRB- cord-302756-343y63e5 20 4 . . . cord-302756-343y63e5 21 1 The the DT cord-302756-343y63e5 21 2 haemostatic haemostatic JJ cord-302756-343y63e5 21 3 system system NN cord-302756-343y63e5 21 4 , , , cord-302756-343y63e5 21 5 by by IN cord-302756-343y63e5 21 6 forming form VBG cord-302756-343y63e5 21 7 a a DT cord-302756-343y63e5 21 8 blood blood NN cord-302756-343y63e5 21 9 clot clot NN cord-302756-343y63e5 21 10 , , , cord-302756-343y63e5 21 11 prevented prevent VBD cord-302756-343y63e5 21 12 the the DT cord-302756-343y63e5 21 13 loss loss NN cord-302756-343y63e5 21 14 of of IN cord-302756-343y63e5 21 15 important important JJ cord-302756-343y63e5 21 16 nutrients nutrient NNS cord-302756-343y63e5 21 17 but but CC cord-302756-343y63e5 21 18 also also RB cord-302756-343y63e5 21 19 formed form VBD cord-302756-343y63e5 21 20 a a DT cord-302756-343y63e5 21 21 barrier barrier NN cord-302756-343y63e5 21 22 to to IN cord-302756-343y63e5 21 23 pathogen pathogen NN cord-302756-343y63e5 21 24 invasion invasion NN cord-302756-343y63e5 21 25 . . . cord-302756-343y63e5 22 1 This this DT cord-302756-343y63e5 22 2 immune immune JJ cord-302756-343y63e5 22 3 function function NN cord-302756-343y63e5 22 4 has have VBZ cord-302756-343y63e5 22 5 been be VBN cord-302756-343y63e5 22 6 explored explore VBN cord-302756-343y63e5 22 7 by by IN cord-302756-343y63e5 22 8 several several JJ cord-302756-343y63e5 22 9 researchers researcher NNS cord-302756-343y63e5 22 10 as as IN cord-302756-343y63e5 22 11 an an DT cord-302756-343y63e5 22 12 immunothrombosis immunothrombosis NN cord-302756-343y63e5 22 13 concept concept NN cord-302756-343y63e5 22 14 [ [ -LRB- cord-302756-343y63e5 22 15 9 9 CD cord-302756-343y63e5 22 16 ] ] -RRB- cord-302756-343y63e5 22 17 . . . cord-302756-343y63e5 23 1 The the DT cord-302756-343y63e5 23 2 various various JJ cord-302756-343y63e5 23 3 components component NNS cord-302756-343y63e5 23 4 of of IN cord-302756-343y63e5 23 5 the the DT cord-302756-343y63e5 23 6 haemostatic haemostatic JJ cord-302756-343y63e5 23 7 system system NN cord-302756-343y63e5 23 8 , , , cord-302756-343y63e5 23 9 including include VBG cord-302756-343y63e5 23 10 the the DT cord-302756-343y63e5 23 11 platelets platelet NNS cord-302756-343y63e5 23 12 , , , cord-302756-343y63e5 23 13 coagulation coagulation NN cord-302756-343y63e5 23 14 factors factor NNS cord-302756-343y63e5 23 15 and and CC cord-302756-343y63e5 23 16 thrombin thrombin NN cord-302756-343y63e5 23 17 , , , cord-302756-343y63e5 23 18 are be VBP cord-302756-343y63e5 23 19 all all DT cord-302756-343y63e5 23 20 immune immune JJ cord-302756-343y63e5 23 21 workers worker NNS cord-302756-343y63e5 23 22 . . . cord-302756-343y63e5 24 1 They -PRON- PRP cord-302756-343y63e5 24 2 function function VBP cord-302756-343y63e5 24 3 as as IN cord-302756-343y63e5 24 4 chemotactic chemotactic VBN cord-302756-343y63e5 24 5 to to IN cord-302756-343y63e5 24 6 the the DT cord-302756-343y63e5 24 7 immune immune JJ cord-302756-343y63e5 24 8 cells cell NNS cord-302756-343y63e5 24 9 , , , cord-302756-343y63e5 24 10 stimulating stimulate VBG cord-302756-343y63e5 24 11 the the DT cord-302756-343y63e5 24 12 various various JJ cord-302756-343y63e5 24 13 immune immune JJ cord-302756-343y63e5 24 14 components component NNS cord-302756-343y63e5 24 15 as as RB cord-302756-343y63e5 24 16 well well RB cord-302756-343y63e5 24 17 as as IN cord-302756-343y63e5 24 18 being be VBG cord-302756-343y63e5 24 19 activated activate VBN cord-302756-343y63e5 24 20 by by IN cord-302756-343y63e5 24 21 the the DT cord-302756-343y63e5 24 22 immune immune JJ cord-302756-343y63e5 24 23 system system NN cord-302756-343y63e5 24 24 themselves -PRON- PRP cord-302756-343y63e5 24 25 [ [ -LRB- cord-302756-343y63e5 24 26 10 10 CD cord-302756-343y63e5 24 27 ] ] -RRB- cord-302756-343y63e5 24 28 [ [ -LRB- cord-302756-343y63e5 24 29 11 11 CD cord-302756-343y63e5 24 30 ] ] -RRB- cord-302756-343y63e5 24 31 [ [ -LRB- cord-302756-343y63e5 24 32 12 12 CD cord-302756-343y63e5 24 33 ] ] -RRB- cord-302756-343y63e5 24 34 . . . cord-302756-343y63e5 25 1 This this DT cord-302756-343y63e5 25 2 bidirectional bidirectional JJ cord-302756-343y63e5 25 3 relationship relationship NN cord-302756-343y63e5 25 4 could could MD cord-302756-343y63e5 25 5 explain explain VB cord-302756-343y63e5 25 6 some some DT cord-302756-343y63e5 25 7 common common JJ cord-302756-343y63e5 25 8 observations observation NNS cord-302756-343y63e5 25 9 with with IN cord-302756-343y63e5 25 10 COVID-19 COVID-19 NNP cord-302756-343y63e5 25 11 . . . cord-302756-343y63e5 26 1 In in IN cord-302756-343y63e5 26 2 the the DT cord-302756-343y63e5 26 3 pandemic pandemic NN cord-302756-343y63e5 26 4 so so RB cord-302756-343y63e5 26 5 far far RB cord-302756-343y63e5 26 6 , , , cord-302756-343y63e5 26 7 we -PRON- PRP cord-302756-343y63e5 26 8 have have VBP cord-302756-343y63e5 26 9 seen see VBN cord-302756-343y63e5 26 10 that that IN cord-302756-343y63e5 26 11 children child NNS cord-302756-343y63e5 26 12 rarely rarely RB cord-302756-343y63e5 26 13 get get VBP cord-302756-343y63e5 26 14 a a DT cord-302756-343y63e5 26 15 severe severe JJ cord-302756-343y63e5 26 16 illness illness NN cord-302756-343y63e5 26 17 despite despite IN cord-302756-343y63e5 26 18 having have VBG cord-302756-343y63e5 26 19 proven prove VBN cord-302756-343y63e5 26 20 infection infection NN cord-302756-343y63e5 26 21 , , , cord-302756-343y63e5 26 22 although although IN cord-302756-343y63e5 26 23 there there EX cord-302756-343y63e5 26 24 have have VBP cord-302756-343y63e5 26 25 been be VBN cord-302756-343y63e5 26 26 recent recent JJ cord-302756-343y63e5 26 27 reports report NNS cord-302756-343y63e5 26 28 of of IN cord-302756-343y63e5 26 29 a a DT cord-302756-343y63e5 26 30 hyperinflammatory hyperinflammatory JJ cord-302756-343y63e5 26 31 response response NN cord-302756-343y63e5 26 32 in in IN cord-302756-343y63e5 26 33 very very RB cord-302756-343y63e5 26 34 small small JJ cord-302756-343y63e5 26 35 numbers number NNS cord-302756-343y63e5 26 36 of of IN cord-302756-343y63e5 26 37 children child NNS cord-302756-343y63e5 26 38 [ [ -LRB- cord-302756-343y63e5 26 39 13 13 CD cord-302756-343y63e5 26 40 ] ] -RRB- cord-302756-343y63e5 26 41 . . . cord-302756-343y63e5 27 1 This this DT cord-302756-343y63e5 27 2 rarity rarity NN cord-302756-343y63e5 27 3 of of IN cord-302756-343y63e5 27 4 severe severe JJ cord-302756-343y63e5 27 5 disease disease NN cord-302756-343y63e5 27 6 may may MD cord-302756-343y63e5 27 7 be be VB cord-302756-343y63e5 27 8 explained explain VBN cord-302756-343y63e5 27 9 by by IN cord-302756-343y63e5 27 10 the the DT cord-302756-343y63e5 27 11 rarity rarity NN cord-302756-343y63e5 27 12 of of IN cord-302756-343y63e5 27 13 thrombotic thrombotic JJ cord-302756-343y63e5 27 14 complications complication NNS cord-302756-343y63e5 27 15 in in IN cord-302756-343y63e5 27 16 the the DT cord-302756-343y63e5 27 17 paediatric paediatric JJ cord-302756-343y63e5 27 18 age age NN cord-302756-343y63e5 27 19 group group NN cord-302756-343y63e5 27 20 in in IN cord-302756-343y63e5 27 21 the the DT cord-302756-343y63e5 27 22 absence absence NN cord-302756-343y63e5 27 23 of of IN cord-302756-343y63e5 27 24 an an DT cord-302756-343y63e5 27 25 underlying underlie VBG cord-302756-343y63e5 27 26 cancer cancer NN cord-302756-343y63e5 27 27 or or CC cord-302756-343y63e5 27 28 a a DT cord-302756-343y63e5 27 29 central central JJ cord-302756-343y63e5 27 30 venous venous JJ cord-302756-343y63e5 27 31 access access NN cord-302756-343y63e5 27 32 device device NN cord-302756-343y63e5 27 33 [ [ -LRB- cord-302756-343y63e5 27 34 14 14 CD cord-302756-343y63e5 27 35 ] ] -RRB- cord-302756-343y63e5 27 36 . . . cord-302756-343y63e5 28 1 Similarly similarly RB cord-302756-343y63e5 28 2 pregnant pregnant JJ cord-302756-343y63e5 28 3 women woman NNS cord-302756-343y63e5 28 4 , , , cord-302756-343y63e5 28 5 despite despite IN cord-302756-343y63e5 28 6 being be VBG cord-302756-343y63e5 28 7 at at IN cord-302756-343y63e5 28 8 risk risk NN cord-302756-343y63e5 28 9 of of IN cord-302756-343y63e5 28 10 clotting clotting NN cord-302756-343y63e5 28 11 problems problem NNS cord-302756-343y63e5 28 12 , , , cord-302756-343y63e5 28 13 tend tend VBP cord-302756-343y63e5 28 14 to to TO cord-302756-343y63e5 28 15 have have VB cord-302756-343y63e5 28 16 milder mild JJR cord-302756-343y63e5 28 17 illness illness NN cord-302756-343y63e5 28 18 . . . cord-302756-343y63e5 29 1 This this DT cord-302756-343y63e5 29 2 may may MD cord-302756-343y63e5 29 3 be be VB cord-302756-343y63e5 29 4 because because IN cord-302756-343y63e5 29 5 their -PRON- PRP$ cord-302756-343y63e5 29 6 immune immune JJ cord-302756-343y63e5 29 7 system system NN cord-302756-343y63e5 29 8 is be VBZ cord-302756-343y63e5 29 9 suppressed suppress VBN cord-302756-343y63e5 29 10 during during IN cord-302756-343y63e5 29 11 the the DT cord-302756-343y63e5 29 12 gestational gestational JJ cord-302756-343y63e5 29 13 period period NN cord-302756-343y63e5 29 14 to to TO cord-302756-343y63e5 29 15 avoid avoid VB cord-302756-343y63e5 29 16 foetal foetal JJ cord-302756-343y63e5 29 17 rejection rejection NN cord-302756-343y63e5 29 18 and and CC cord-302756-343y63e5 30 1 hence hence RB cord-302756-343y63e5 30 2 the the DT cord-302756-343y63e5 30 3 double double JJ cord-302756-343y63e5 30 4 hit hit NN cord-302756-343y63e5 30 5 of of IN cord-302756-343y63e5 30 6 immunothrombosis immunothrombosis NN cord-302756-343y63e5 30 7 does do VBZ cord-302756-343y63e5 30 8 not not RB cord-302756-343y63e5 30 9 come come VB cord-302756-343y63e5 30 10 into into IN cord-302756-343y63e5 30 11 play play NN cord-302756-343y63e5 30 12 [ [ -LRB- cord-302756-343y63e5 30 13 15 15 CD cord-302756-343y63e5 30 14 ] ] -RRB- cord-302756-343y63e5 30 15 . . . cord-302756-343y63e5 31 1 On on IN cord-302756-343y63e5 31 2 the the DT cord-302756-343y63e5 31 3 other other JJ cord-302756-343y63e5 31 4 hand hand NN cord-302756-343y63e5 31 5 , , , cord-302756-343y63e5 31 6 older old JJR cord-302756-343y63e5 31 7 individuals individual NNS cord-302756-343y63e5 31 8 , , , cord-302756-343y63e5 31 9 who who WP cord-302756-343y63e5 31 10 are be VBP cord-302756-343y63e5 31 11 more more RBR cord-302756-343y63e5 31 12 prone prone JJ cord-302756-343y63e5 31 13 to to IN cord-302756-343y63e5 31 14 getting get VBG cord-302756-343y63e5 31 15 thrombotic thrombotic JJ cord-302756-343y63e5 31 16 complications complication NNS cord-302756-343y63e5 31 17 in in IN cord-302756-343y63e5 31 18 the the DT cord-302756-343y63e5 31 19 pre pre JJ cord-302756-343y63e5 31 20 - - JJ cord-302756-343y63e5 31 21 COVID-19 covid-19 JJ cord-302756-343y63e5 31 22 era era NN cord-302756-343y63e5 31 23 , , , cord-302756-343y63e5 31 24 are be VBP cord-302756-343y63e5 31 25 more more RBR cord-302756-343y63e5 31 26 likely likely JJ cord-302756-343y63e5 31 27 to to TO cord-302756-343y63e5 31 28 get get VB cord-302756-343y63e5 31 29 severe severe JJ cord-302756-343y63e5 31 30 disease disease NN cord-302756-343y63e5 31 31 . . . cord-302756-343y63e5 32 1 The the DT cord-302756-343y63e5 32 2 differences difference NNS cord-302756-343y63e5 32 3 in in IN cord-302756-343y63e5 32 4 mortality mortality NN cord-302756-343y63e5 32 5 between between IN cord-302756-343y63e5 32 6 the the DT cord-302756-343y63e5 32 7 South South NNP cord-302756-343y63e5 32 8 East East NNP cord-302756-343y63e5 32 9 Asian asian JJ cord-302756-343y63e5 32 10 and and CC cord-302756-343y63e5 32 11 Western western JJ cord-302756-343y63e5 32 12 cohorts cohort NNS cord-302756-343y63e5 32 13 affected affect VBN cord-302756-343y63e5 32 14 by by IN cord-302756-343y63e5 32 15 COVID-19 COVID-19 NNP cord-302756-343y63e5 32 16 could could MD cord-302756-343y63e5 32 17 also also RB cord-302756-343y63e5 32 18 be be VB cord-302756-343y63e5 32 19 explained explain VBN cord-302756-343y63e5 32 20 by by IN cord-302756-343y63e5 32 21 the the DT cord-302756-343y63e5 32 22 lack lack NN cord-302756-343y63e5 32 23 of of IN cord-302756-343y63e5 32 24 prothrombotic prothrombotic JJ cord-302756-343y63e5 32 25 tendencies tendency NNS cord-302756-343y63e5 32 26 in in IN cord-302756-343y63e5 32 27 the the DT cord-302756-343y63e5 32 28 South South NNP cord-302756-343y63e5 32 29 East east JJ cord-302756-343y63e5 32 30 Asian asian JJ cord-302756-343y63e5 32 31 population population NN cord-302756-343y63e5 32 32 [ [ -LRB- cord-302756-343y63e5 32 33 16 16 CD cord-302756-343y63e5 32 34 ] ] -RRB- cord-302756-343y63e5 32 35 . . . cord-302756-343y63e5 33 1 We -PRON- PRP cord-302756-343y63e5 33 2 must must MD cord-302756-343y63e5 33 3 wonder wonder VB cord-302756-343y63e5 33 4 , , , cord-302756-343y63e5 33 5 however however RB cord-302756-343y63e5 33 6 , , , cord-302756-343y63e5 33 7 why why WRB cord-302756-343y63e5 33 8 some some DT cord-302756-343y63e5 33 9 Western western JJ cord-302756-343y63e5 33 10 patients patient NNS cord-302756-343y63e5 33 11 affected affect VBN cord-302756-343y63e5 33 12 by by IN cord-302756-343y63e5 33 13 the the DT cord-302756-343y63e5 33 14 virus virus NN cord-302756-343y63e5 33 15 get get VBP cord-302756-343y63e5 33 16 severe severe JJ cord-302756-343y63e5 33 17 respiratory respiratory JJ cord-302756-343y63e5 33 18 compromise compromise NN cord-302756-343y63e5 33 19 requiring require VBG cord-302756-343y63e5 33 20 critical critical JJ cord-302756-343y63e5 33 21 care care NN cord-302756-343y63e5 33 22 support support NN cord-302756-343y63e5 33 23 whilst whilst IN cord-302756-343y63e5 33 24 others other NNS cord-302756-343y63e5 33 25 have have VBP cord-302756-343y63e5 33 26 a a DT cord-302756-343y63e5 33 27 relatively relatively RB cord-302756-343y63e5 33 28 mild mild JJ cord-302756-343y63e5 33 29 illness illness NN cord-302756-343y63e5 33 30 ? ? . cord-302756-343y63e5 34 1 This this DT cord-302756-343y63e5 34 2 article article NN cord-302756-343y63e5 34 3 is be VBZ cord-302756-343y63e5 34 4 protected protect VBN cord-302756-343y63e5 34 5 by by IN cord-302756-343y63e5 34 6 copyright copyright NN cord-302756-343y63e5 34 7 . . . cord-302756-343y63e5 35 1 All all DT cord-302756-343y63e5 35 2 rights right NNS cord-302756-343y63e5 35 3 reserved reserve VBN cord-302756-343y63e5 35 4 SARS SARS NNP cord-302756-343y63e5 35 5 - - HYPH cord-302756-343y63e5 35 6 Cov-2 Cov-2 NNP cord-302756-343y63e5 35 7 gains gain NNS cord-302756-343y63e5 35 8 entry entry NN cord-302756-343y63e5 35 9 predominantly predominantly RB cord-302756-343y63e5 35 10 through through IN cord-302756-343y63e5 35 11 the the DT cord-302756-343y63e5 35 12 lungs lung NNS cord-302756-343y63e5 35 13 . . . cord-302756-343y63e5 36 1 In in IN cord-302756-343y63e5 36 2 the the DT cord-302756-343y63e5 36 3 lungs lung NNS cord-302756-343y63e5 36 4 , , , cord-302756-343y63e5 36 5 a a DT cord-302756-343y63e5 36 6 localised localised JJ cord-302756-343y63e5 36 7 coagulation coagulation NN cord-302756-343y63e5 36 8 system system NN cord-302756-343y63e5 36 9 or or CC cord-302756-343y63e5 36 10 broncho broncho JJ cord-302756-343y63e5 36 11 - - HYPH cord-302756-343y63e5 36 12 alveolar alveolar NN cord-302756-343y63e5 36 13 haemostasis haemostasis NN cord-302756-343y63e5 36 14 is be VBZ cord-302756-343y63e5 36 15 present present JJ cord-302756-343y63e5 36 16 which which WDT cord-302756-343y63e5 36 17 tries try VBZ cord-302756-343y63e5 36 18 to to TO cord-302756-343y63e5 36 19 fight fight VB cord-302756-343y63e5 36 20 the the DT cord-302756-343y63e5 36 21 infection infection NN cord-302756-343y63e5 36 22 along along IN cord-302756-343y63e5 36 23 with with IN cord-302756-343y63e5 36 24 the the DT cord-302756-343y63e5 36 25 immune immune JJ cord-302756-343y63e5 36 26 cells cell NNS cord-302756-343y63e5 36 27 [ [ -LRB- cord-302756-343y63e5 36 28 17 17 CD cord-302756-343y63e5 36 29 ] ] -RRB- cord-302756-343y63e5 36 30 . . . cord-302756-343y63e5 37 1 The the DT cord-302756-343y63e5 37 2 proof proof NN cord-302756-343y63e5 37 3 for for IN cord-302756-343y63e5 37 4 this this DT cord-302756-343y63e5 37 5 lung lung NN cord-302756-343y63e5 37 6 - - HYPH cord-302756-343y63e5 37 7 specific specific JJ cord-302756-343y63e5 37 8 clot clot NN cord-302756-343y63e5 37 9 formation formation NN cord-302756-343y63e5 37 10 comes come VBZ cord-302756-343y63e5 37 11 from from IN cord-302756-343y63e5 37 12 two two CD cord-302756-343y63e5 37 13 things thing NNS cord-302756-343y63e5 37 14 . . . cord-302756-343y63e5 38 1 Firstly firstly RB cord-302756-343y63e5 38 2 , , , cord-302756-343y63e5 38 3 the the DT cord-302756-343y63e5 38 4 marked marked JJ cord-302756-343y63e5 38 5 acute acute JJ cord-302756-343y63e5 38 6 phase phase NN cord-302756-343y63e5 38 7 response response NN cord-302756-343y63e5 38 8 includes include VBZ cord-302756-343y63e5 38 9 platelets platelet NNS cord-302756-343y63e5 38 10 and and CC cord-302756-343y63e5 38 11 fibrinogen fibrinogen NN cord-302756-343y63e5 38 12 in in IN cord-302756-343y63e5 38 13 addition addition NN cord-302756-343y63e5 38 14 to to IN cord-302756-343y63e5 38 15 other other JJ cord-302756-343y63e5 38 16 well well RB cord-302756-343y63e5 38 17 - - HYPH cord-302756-343y63e5 38 18 known know VBN cord-302756-343y63e5 38 19 markers marker NNS cord-302756-343y63e5 38 20 such such JJ cord-302756-343y63e5 38 21 as as IN cord-302756-343y63e5 38 22 C C NNP cord-302756-343y63e5 38 23 - - HYPH cord-302756-343y63e5 38 24 reactive reactive JJ cord-302756-343y63e5 38 25 protein protein NN cord-302756-343y63e5 38 26 and and CC cord-302756-343y63e5 38 27 ferritin ferritin NN cord-302756-343y63e5 38 28 . . . cord-302756-343y63e5 39 1 Platelet platelet NN cord-302756-343y63e5 39 2 counts count NNS cord-302756-343y63e5 39 3 are be VBP cord-302756-343y63e5 39 4 increased increase VBN cord-302756-343y63e5 39 5 in in IN cord-302756-343y63e5 39 6 these these DT cord-302756-343y63e5 39 7 patients patient NNS cord-302756-343y63e5 39 8 in in IN cord-302756-343y63e5 39 9 the the DT cord-302756-343y63e5 39 10 initial initial JJ cord-302756-343y63e5 39 11 stages stage NNS cord-302756-343y63e5 39 12 ( ( -LRB- cord-302756-343y63e5 39 13 uncommonly uncommonly RB cord-302756-343y63e5 39 14 reported report VBN cord-302756-343y63e5 39 15 in in IN cord-302756-343y63e5 39 16 patients patient NNS cord-302756-343y63e5 39 17 with with IN cord-302756-343y63e5 39 18 infectious infectious JJ cord-302756-343y63e5 39 19 diseases disease NNS cord-302756-343y63e5 39 20 ) ) -RRB- cord-302756-343y63e5 39 21 and and CC cord-302756-343y63e5 39 22 are be VBP cord-302756-343y63e5 39 23 almost almost RB cord-302756-343y63e5 39 24 never never RB cord-302756-343y63e5 39 25 severely severely RB cord-302756-343y63e5 39 26 low low JJ cord-302756-343y63e5 39 27 , , , cord-302756-343y63e5 39 28 even even RB cord-302756-343y63e5 39 29 in in IN cord-302756-343y63e5 39 30 critically critically RB cord-302756-343y63e5 39 31 ill ill JJ cord-302756-343y63e5 39 32 COVID-19 covid-19 CD cord-302756-343y63e5 39 33 patients patient NNS cord-302756-343y63e5 39 34 [ [ -LRB- cord-302756-343y63e5 39 35 18 18 CD cord-302756-343y63e5 39 36 ] ] -RRB- cord-302756-343y63e5 39 37 . . . cord-302756-343y63e5 40 1 Similarly similarly RB cord-302756-343y63e5 40 2 , , , cord-302756-343y63e5 40 3 fibrinogen fibrinogen NN cord-302756-343y63e5 40 4 is be VBZ cord-302756-343y63e5 40 5 markedly markedly RB cord-302756-343y63e5 40 6 raised raise VBN cord-302756-343y63e5 40 7 in in IN cord-302756-343y63e5 40 8 these these DT cord-302756-343y63e5 40 9 patients patient NNS cord-302756-343y63e5 40 10 and and CC cord-302756-343y63e5 40 11 has have VBZ cord-302756-343y63e5 40 12 been be VBN cord-302756-343y63e5 40 13 historically historically RB cord-302756-343y63e5 40 14 recognised recognise VBN cord-302756-343y63e5 40 15 as as IN cord-302756-343y63e5 40 16 a a DT cord-302756-343y63e5 40 17 marker marker NN cord-302756-343y63e5 40 18 of of IN cord-302756-343y63e5 40 19 hypercoagulability hypercoagulability NN cord-302756-343y63e5 40 20 [ [ -LRB- cord-302756-343y63e5 40 21 19 19 CD cord-302756-343y63e5 40 22 ] ] -RRB- cord-302756-343y63e5 40 23 . . . cord-302756-343y63e5 41 1 Secondly secondly RB cord-302756-343y63e5 41 2 , , , cord-302756-343y63e5 41 3 post post JJ cord-302756-343y63e5 41 4 - - JJ cord-302756-343y63e5 41 5 mortem mortem JJ cord-302756-343y63e5 41 6 examinations examination NNS cord-302756-343y63e5 41 7 have have VBP cord-302756-343y63e5 41 8 found find VBN cord-302756-343y63e5 41 9 evidence evidence NN cord-302756-343y63e5 41 10 of of IN cord-302756-343y63e5 41 11 pulmonary pulmonary JJ cord-302756-343y63e5 41 12 microthrombi microthrombi NN cord-302756-343y63e5 41 13 in in IN cord-302756-343y63e5 41 14 patients patient NNS cord-302756-343y63e5 41 15 with with IN cord-302756-343y63e5 41 16 COVID-19 COVID-19 NNP cord-302756-343y63e5 41 17 [ [ -LRB- cord-302756-343y63e5 41 18 20 20 CD cord-302756-343y63e5 41 19 ] ] -RRB- cord-302756-343y63e5 41 20 . . . cord-302756-343y63e5 42 1 There there EX cord-302756-343y63e5 42 2 are be VBP cord-302756-343y63e5 42 3 also also RB cord-302756-343y63e5 42 4 suggestions suggestion NNS cord-302756-343y63e5 42 5 that that IN cord-302756-343y63e5 42 6 the the DT cord-302756-343y63e5 42 7 different different JJ cord-302756-343y63e5 42 8 ventilatory ventilatory JJ cord-302756-343y63e5 42 9 patterns pattern NNS cord-302756-343y63e5 42 10 in in IN cord-302756-343y63e5 42 11 COVID-19 COVID-19 NNP cord-302756-343y63e5 42 12 may may MD cord-302756-343y63e5 42 13 suggest suggest VB cord-302756-343y63e5 42 14 microthrombi microthrombi NNP cord-302756-343y63e5 42 15 to to TO cord-302756-343y63e5 42 16 be be VB cord-302756-343y63e5 42 17 a a DT cord-302756-343y63e5 42 18 key key JJ cord-302756-343y63e5 42 19 component component NN cord-302756-343y63e5 42 20 of of IN cord-302756-343y63e5 42 21 clinical clinical JJ cord-302756-343y63e5 42 22 deterioration deterioration NN cord-302756-343y63e5 42 23 [ [ -LRB- cord-302756-343y63e5 42 24 21 21 CD cord-302756-343y63e5 42 25 ] ] -RRB- cord-302756-343y63e5 42 26 . . . cord-302756-343y63e5 43 1 In in IN cord-302756-343y63e5 43 2 non non JJ cord-302756-343y63e5 43 3 - - JJ cord-302756-343y63e5 43 4 severe severe JJ cord-302756-343y63e5 43 5 COVID-19 covid-19 NN cord-302756-343y63e5 43 6 , , , cord-302756-343y63e5 43 7 these these DT cord-302756-343y63e5 43 8 microthrombi microthrombi NN cord-302756-343y63e5 43 9 are be VBP cord-302756-343y63e5 43 10 broken break VBN cord-302756-343y63e5 43 11 down down RP cord-302756-343y63e5 43 12 by by IN cord-302756-343y63e5 43 13 the the DT cord-302756-343y63e5 43 14 highly highly RB cord-302756-343y63e5 43 15 active active JJ cord-302756-343y63e5 43 16 fibrinolytic fibrinolytic JJ cord-302756-343y63e5 43 17 function function NN cord-302756-343y63e5 43 18 in in IN cord-302756-343y63e5 43 19 the the DT cord-302756-343y63e5 43 20 lungs lung NNS cord-302756-343y63e5 43 21 to to TO cord-302756-343y63e5 43 22 allow allow VB cord-302756-343y63e5 43 23 gas gas NN cord-302756-343y63e5 43 24 exchange exchange NN cord-302756-343y63e5 43 25 which which WDT cord-302756-343y63e5 43 26 is be VBZ cord-302756-343y63e5 43 27 noted note VBN cord-302756-343y63e5 43 28 as as IN cord-302756-343y63e5 43 29 an an DT cord-302756-343y63e5 43 30 elevation elevation NN cord-302756-343y63e5 43 31 in in IN cord-302756-343y63e5 43 32 D d NN cord-302756-343y63e5 43 33 - - HYPH cord-302756-343y63e5 43 34 dimers dimer NNS cord-302756-343y63e5 43 35 . . . cord-302756-343y63e5 44 1 In in IN cord-302756-343y63e5 44 2 severely severely RB cord-302756-343y63e5 44 3 ill ill JJ cord-302756-343y63e5 44 4 patients patient NNS cord-302756-343y63e5 44 5 , , , cord-302756-343y63e5 44 6 the the DT cord-302756-343y63e5 44 7 pulmonary pulmonary JJ cord-302756-343y63e5 44 8 coagulation coagulation NN cord-302756-343y63e5 44 9 system system NN cord-302756-343y63e5 44 10 becomes become VBZ cord-302756-343y63e5 44 11 markedly markedly RB cord-302756-343y63e5 44 12 activated activate VBN cord-302756-343y63e5 44 13 . . . cord-302756-343y63e5 45 1 This this DT cord-302756-343y63e5 45 2 would would MD cord-302756-343y63e5 45 3 be be VB cord-302756-343y63e5 45 4 clinically clinically RB cord-302756-343y63e5 45 5 manifest manifest JJ cord-302756-343y63e5 45 6 as as IN cord-302756-343y63e5 45 7 increased increase VBN cord-302756-343y63e5 45 8 oxygen oxygen NN cord-302756-343y63e5 45 9 requirements requirement NNS cord-302756-343y63e5 45 10 and and CC cord-302756-343y63e5 45 11 possibly possibly RB cord-302756-343y63e5 45 12 as as IN cord-302756-343y63e5 45 13 an an DT cord-302756-343y63e5 45 14 increased increase VBN cord-302756-343y63e5 45 15 incidence incidence NN cord-302756-343y63e5 45 16 of of IN cord-302756-343y63e5 45 17 renal renal JJ cord-302756-343y63e5 45 18 impairment impairment NN cord-302756-343y63e5 45 19 ( ( -LRB- cord-302756-343y63e5 45 20 latest late JJS cord-302756-343y63e5 45 21 ICNARC ICNARC NNP cord-302756-343y63e5 45 22 data datum NNS cord-302756-343y63e5 45 23 _SP cord-302756-343y63e5 45 24 Based Based NNP cord-302756-343y63e5 45 25 on on IN cord-302756-343y63e5 45 26 several several JJ cord-302756-343y63e5 45 27 reports report NNS cord-302756-343y63e5 45 28 of of IN cord-302756-343y63e5 45 29 hypercoagulability hypercoagulability NN cord-302756-343y63e5 45 30 , , , cord-302756-343y63e5 45 31 it -PRON- PRP cord-302756-343y63e5 45 32 is be VBZ cord-302756-343y63e5 45 33 now now RB cord-302756-343y63e5 45 34 recognised recognise VBN cord-302756-343y63e5 45 35 that that IN cord-302756-343y63e5 45 36 all all DT cord-302756-343y63e5 45 37 patients patient NNS cord-302756-343y63e5 45 38 with with IN cord-302756-343y63e5 45 39 COVID-19 covid-19 JJ cord-302756-343y63e5 45 40 requiring require VBG cord-302756-343y63e5 45 41 hospitalisation hospitalisation NN cord-302756-343y63e5 45 42 require require VBP cord-302756-343y63e5 45 43 prophylactic prophylactic JJ cord-302756-343y63e5 45 44 anticoagulation anticoagulation NN cord-302756-343y63e5 45 45 in in IN cord-302756-343y63e5 45 46 the the DT cord-302756-343y63e5 45 47 absence absence NN cord-302756-343y63e5 45 48 of of IN cord-302756-343y63e5 45 49 absolute absolute JJ cord-302756-343y63e5 45 50 contraindications contraindication NNS cord-302756-343y63e5 45 51 [ [ -LRB- cord-302756-343y63e5 45 52 22 22 CD cord-302756-343y63e5 45 53 , , , cord-302756-343y63e5 45 54 23 23 CD cord-302756-343y63e5 45 55 ] ] -RRB- cord-302756-343y63e5 45 56 . . . cord-302756-343y63e5 46 1 However however RB cord-302756-343y63e5 46 2 , , , cord-302756-343y63e5 46 3 in in IN cord-302756-343y63e5 46 4 patients patient NNS cord-302756-343y63e5 46 5 where where WRB cord-302756-343y63e5 46 6 localised localised JJ cord-302756-343y63e5 46 7 pulmonary pulmonary JJ cord-302756-343y63e5 46 8 coagulopathy coagulopathy NN cord-302756-343y63e5 46 9 may may MD cord-302756-343y63e5 46 10 progress progress VB cord-302756-343y63e5 46 11 or or CC cord-302756-343y63e5 46 12 have have VBP cord-302756-343y63e5 46 13 already already RB cord-302756-343y63e5 46 14 become become VBN cord-302756-343y63e5 46 15 systemic systemic JJ cord-302756-343y63e5 46 16 , , , cord-302756-343y63e5 46 17 prophylactic prophylactic JJ cord-302756-343y63e5 46 18 anticoagulation anticoagulation NN cord-302756-343y63e5 46 19 might may MD cord-302756-343y63e5 46 20 be be VB cord-302756-343y63e5 46 21 inadequate inadequate JJ cord-302756-343y63e5 46 22 . . . cord-302756-343y63e5 47 1 There there EX cord-302756-343y63e5 47 2 are be VBP cord-302756-343y63e5 47 3 currently currently RB cord-302756-343y63e5 47 4 several several JJ cord-302756-343y63e5 47 5 trials trial NNS cord-302756-343y63e5 47 6 looking look VBG cord-302756-343y63e5 47 7 at at IN cord-302756-343y63e5 47 8 an an DT cord-302756-343y63e5 47 9 increased increase VBN cord-302756-343y63e5 47 10 dose dose NN cord-302756-343y63e5 47 11 of of IN cord-302756-343y63e5 47 12 anticoagulation anticoagulation NN cord-302756-343y63e5 47 13 , , , cord-302756-343y63e5 47 14 even even RB cord-302756-343y63e5 47 15 therapeutic therapeutic JJ cord-302756-343y63e5 47 16 anticoagulation anticoagulation NN cord-302756-343y63e5 47 17 in in IN cord-302756-343y63e5 47 18 such such JJ cord-302756-343y63e5 47 19 patients patient NNS cord-302756-343y63e5 47 20 . . . cord-302756-343y63e5 48 1 It -PRON- PRP cord-302756-343y63e5 48 2 is be VBZ cord-302756-343y63e5 48 3 important important JJ cord-302756-343y63e5 48 4 to to TO cord-302756-343y63e5 48 5 bear bear VB cord-302756-343y63e5 48 6 in in IN cord-302756-343y63e5 48 7 mind mind NN cord-302756-343y63e5 48 8 that that IN cord-302756-343y63e5 48 9 systemic systemic JJ cord-302756-343y63e5 48 10 coagulopathy coagulopathy NN cord-302756-343y63e5 48 11 may may MD cord-302756-343y63e5 48 12 not not RB cord-302756-343y63e5 48 13 be be VB cord-302756-343y63e5 48 14 treated treat VBN cord-302756-343y63e5 48 15 with with IN cord-302756-343y63e5 48 16 full full JJ cord-302756-343y63e5 48 17 - - HYPH cord-302756-343y63e5 48 18 dose dose NN cord-302756-343y63e5 48 19 anticoagulation anticoagulation NN cord-302756-343y63e5 48 20 in in IN cord-302756-343y63e5 48 21 all all DT cord-302756-343y63e5 48 22 cases case NNS cord-302756-343y63e5 48 23 . . . cord-302756-343y63e5 49 1 It -PRON- PRP cord-302756-343y63e5 49 2 is be VBZ cord-302756-343y63e5 49 3 likely likely JJ cord-302756-343y63e5 49 4 that that IN cord-302756-343y63e5 49 5 extra extra JJ cord-302756-343y63e5 49 6 - - JJ cord-302756-343y63e5 49 7 pulmonary pulmonary JJ cord-302756-343y63e5 49 8 coagulopathy coagulopathy NN cord-302756-343y63e5 49 9 requires require VBZ cord-302756-343y63e5 49 10 more more RBR cord-302756-343y63e5 49 11 aggressive aggressive JJ cord-302756-343y63e5 49 12 anti anti JJ cord-302756-343y63e5 49 13 - - JJ cord-302756-343y63e5 49 14 thrombotic thrombotic JJ cord-302756-343y63e5 49 15 therapies therapy NNS cord-302756-343y63e5 49 16 ( ( -LRB- cord-302756-343y63e5 49 17 for for IN cord-302756-343y63e5 49 18 example example NN cord-302756-343y63e5 49 19 additional additional JJ cord-302756-343y63e5 49 20 antiplatelet antiplatelet NN cord-302756-343y63e5 49 21 drugs drug NNS cord-302756-343y63e5 49 22 or or CC cord-302756-343y63e5 49 23 thrombolysis thrombolysis NN cord-302756-343y63e5 49 24 ) ) -RRB- cord-302756-343y63e5 49 25 and and CC cord-302756-343y63e5 49 26 treatments treatment NNS cord-302756-343y63e5 49 27 which which WDT cord-302756-343y63e5 49 28 can can MD cord-302756-343y63e5 49 29 impact impact VB cord-302756-343y63e5 49 30 on on IN cord-302756-343y63e5 49 31 the the DT cord-302756-343y63e5 49 32 immunothrombosis immunothrombosis NN cord-302756-343y63e5 49 33 models model NNS cord-302756-343y63e5 49 34 ( ( -LRB- cord-302756-343y63e5 49 35 for for IN cord-302756-343y63e5 49 36 example example NN cord-302756-343y63e5 49 37 immunomodulatory immunomodulatory JJ cord-302756-343y63e5 49 38 agents agent NNS cord-302756-343y63e5 49 39 and and CC cord-302756-343y63e5 49 40 anti anti JJ cord-302756-343y63e5 49 41 - - JJ cord-302756-343y63e5 49 42 complement complement JJ cord-302756-343y63e5 49 43 drugs drug NNS cord-302756-343y63e5 49 44 ) ) -RRB- cord-302756-343y63e5 49 45 [ [ -LRB- cord-302756-343y63e5 49 46 24 24 CD cord-302756-343y63e5 49 47 ] ] -RRB- cord-302756-343y63e5 49 48 [ [ -LRB- cord-302756-343y63e5 49 49 25 25 CD cord-302756-343y63e5 49 50 ] ] -RRB- cord-302756-343y63e5 49 51 [ [ -LRB- cord-302756-343y63e5 49 52 26 26 CD cord-302756-343y63e5 49 53 ] ] -RRB- cord-302756-343y63e5 49 54 [ [ -LRB- cord-302756-343y63e5 49 55 27 27 CD cord-302756-343y63e5 49 56 ] ] -RRB- cord-302756-343y63e5 49 57 . . . cord-302756-343y63e5 50 1 It -PRON- PRP cord-302756-343y63e5 50 2 would would MD cord-302756-343y63e5 50 3 be be VB cord-302756-343y63e5 50 4 ideal ideal JJ cord-302756-343y63e5 50 5 in in IN cord-302756-343y63e5 50 6 these these DT cord-302756-343y63e5 50 7 situations situation NNS cord-302756-343y63e5 50 8 This this DT cord-302756-343y63e5 50 9 article article NN cord-302756-343y63e5 50 10 is be VBZ cord-302756-343y63e5 50 11 protected protect VBN cord-302756-343y63e5 50 12 by by IN cord-302756-343y63e5 50 13 copyright copyright NN cord-302756-343y63e5 50 14 . . . cord-302756-343y63e5 51 1 All all DT cord-302756-343y63e5 51 2 rights right NNS cord-302756-343y63e5 51 3 reserved reserve VBN cord-302756-343y63e5 51 4 to to TO cord-302756-343y63e5 51 5 depend depend VB cord-302756-343y63e5 51 6 on on IN cord-302756-343y63e5 51 7 laboratory laboratory NN cord-302756-343y63e5 51 8 markers marker NNS cord-302756-343y63e5 51 9 which which WDT cord-302756-343y63e5 51 10 can can MD cord-302756-343y63e5 51 11 predict predict VB cord-302756-343y63e5 51 12 the the DT cord-302756-343y63e5 51 13 transition transition NN cord-302756-343y63e5 51 14 from from IN cord-302756-343y63e5 51 15 the the DT cord-302756-343y63e5 51 16 beneficial beneficial JJ cord-302756-343y63e5 51 17 pulmonary pulmonary JJ cord-302756-343y63e5 51 18 coagulation coagulation NN cord-302756-343y63e5 51 19 activation activation NN cord-302756-343y63e5 51 20 to to IN cord-302756-343y63e5 51 21 harmful harmful JJ cord-302756-343y63e5 51 22 systemic systemic JJ cord-302756-343y63e5 51 23 spread spread NN cord-302756-343y63e5 51 24 . . . cord-302756-343y63e5 52 1 Based base VBN cord-302756-343y63e5 52 2 on on IN cord-302756-343y63e5 52 3 the the DT cord-302756-343y63e5 52 4 currently currently RB cord-302756-343y63e5 52 5 available available JJ cord-302756-343y63e5 52 6 laboratory laboratory NN cord-302756-343y63e5 52 7 markers marker NNS cord-302756-343y63e5 52 8 , , , cord-302756-343y63e5 52 9 of of IN cord-302756-343y63e5 52 10 which which WDT cord-302756-343y63e5 52 11 D d NN cord-302756-343y63e5 52 12 - - HYPH cord-302756-343y63e5 52 13 dimers dimer NNS cord-302756-343y63e5 52 14 seem seem VBP cord-302756-343y63e5 52 15 to to TO cord-302756-343y63e5 52 16 be be VB cord-302756-343y63e5 52 17 the the DT cord-302756-343y63e5 52 18 most most RBS cord-302756-343y63e5 52 19 consistent consistent JJ cord-302756-343y63e5 52 20 , , , cord-302756-343y63e5 52 21 we -PRON- PRP cord-302756-343y63e5 52 22 provide provide VBP cord-302756-343y63e5 52 23 a a DT cord-302756-343y63e5 52 24 suggested suggest VBN cord-302756-343y63e5 52 25 approach approach NN cord-302756-343y63e5 52 26 but but CC cord-302756-343y63e5 52 27 stress stress NN cord-302756-343y63e5 52 28 that that IN cord-302756-343y63e5 52 29 this this DT cord-302756-343y63e5 52 30 requires require VBZ cord-302756-343y63e5 52 31 confirmation confirmation NN cord-302756-343y63e5 52 32 from from IN cord-302756-343y63e5 52 33 ongoing ongoing JJ cord-302756-343y63e5 52 34 trials trial NNS cord-302756-343y63e5 52 35 ( ( -LRB- cord-302756-343y63e5 52 36 Fig Fig NNP cord-302756-343y63e5 52 37 . . NNP cord-302756-343y63e5 52 38 1 1 CD cord-302756-343y63e5 52 39 ) ) -RRB- cord-302756-343y63e5 52 40 . . . cord-302756-343y63e5 53 1 When when WRB cord-302756-343y63e5 53 2 the the DT cord-302756-343y63e5 53 3 patient patient NN cord-302756-343y63e5 53 4 presents present VBZ cord-302756-343y63e5 53 5 to to IN cord-302756-343y63e5 53 6 the the DT cord-302756-343y63e5 53 7 hospital hospital NN cord-302756-343y63e5 53 8 , , , cord-302756-343y63e5 53 9 if if IN cord-302756-343y63e5 53 10 the the DT cord-302756-343y63e5 53 11 D d NN cord-302756-343y63e5 53 12 - - HYPH cord-302756-343y63e5 53 13 dimers dimer NNS cord-302756-343y63e5 53 14 are be VBP cord-302756-343y63e5 53 15 increased increase VBN cord-302756-343y63e5 53 16 , , , cord-302756-343y63e5 53 17 prophylactic prophylactic JJ cord-302756-343y63e5 53 18 anticoagulation anticoagulation NN cord-302756-343y63e5 53 19 with with IN cord-302756-343y63e5 53 20 low low JJ cord-302756-343y63e5 53 21 molecular molecular JJ cord-302756-343y63e5 53 22 weight weight NN cord-302756-343y63e5 53 23 heparin heparin NN cord-302756-343y63e5 53 24 should should MD cord-302756-343y63e5 53 25 be be VB cord-302756-343y63e5 53 26 given give VBN cord-302756-343y63e5 53 27 to to IN cord-302756-343y63e5 53 28 all all DT cord-302756-343y63e5 53 29 patients patient NNS cord-302756-343y63e5 53 30 in in IN cord-302756-343y63e5 53 31 the the DT cord-302756-343y63e5 53 32 absence absence NN cord-302756-343y63e5 53 33 of of IN cord-302756-343y63e5 53 34 contraindications contraindication NNS cord-302756-343y63e5 53 35 as as IN cord-302756-343y63e5 53 36 per per IN cord-302756-343y63e5 53 37 current current JJ cord-302756-343y63e5 53 38 guidance guidance NN cord-302756-343y63e5 53 39 documents document NNS cord-302756-343y63e5 53 40 [ [ -LRB- cord-302756-343y63e5 53 41 22 22 CD cord-302756-343y63e5 53 42 , , , cord-302756-343y63e5 53 43 23 23 CD cord-302756-343y63e5 53 44 ] ] -RRB- cord-302756-343y63e5 53 45 . . . cord-302756-343y63e5 54 1 like like IN cord-302756-343y63e5 54 2 antiplatelets antiplatelet NNS cord-302756-343y63e5 54 3 and and CC cord-302756-343y63e5 54 4 others other NNS cord-302756-343y63e5 54 5 ( ( -LRB- cord-302756-343y63e5 54 6 described describe VBN cord-302756-343y63e5 54 7 above above RB cord-302756-343y63e5 54 8 ) ) -RRB- cord-302756-343y63e5 54 9 should should MD cord-302756-343y63e5 54 10 be be VB cord-302756-343y63e5 54 11 considered consider VBN cord-302756-343y63e5 54 12 in in IN cord-302756-343y63e5 54 13 a a DT cord-302756-343y63e5 54 14 trial trial NN cord-302756-343y63e5 54 15 setting setting NN cord-302756-343y63e5 54 16 . . . cord-302756-343y63e5 55 1 Thrombolysis thrombolysis NN cord-302756-343y63e5 55 2 using use VBG cord-302756-343y63e5 55 3 inhaled inhale VBN cord-302756-343y63e5 55 4 or or CC cord-302756-343y63e5 55 5 systemic systemic JJ cord-302756-343y63e5 55 6 tissue tissue NN cord-302756-343y63e5 55 7 plasminogen plasminogen NN cord-302756-343y63e5 55 8 activator activator NN cord-302756-343y63e5 55 9 has have VBZ cord-302756-343y63e5 55 10 been be VBN cord-302756-343y63e5 55 11 attempted attempt VBN cord-302756-343y63e5 55 12 in in IN cord-302756-343y63e5 55 13 some some DT cord-302756-343y63e5 55 14 patients patient NNS cord-302756-343y63e5 55 15 who who WP cord-302756-343y63e5 55 16 worsen worsen VBP cord-302756-343y63e5 55 17 despite despite IN cord-302756-343y63e5 55 18 therapeutic therapeutic JJ cord-302756-343y63e5 55 19 anticoagulation anticoagulation NN cord-302756-343y63e5 55 20 and and CC cord-302756-343y63e5 55 21 maximal maximal JJ cord-302756-343y63e5 55 22 critical critical JJ cord-302756-343y63e5 55 23 care care NN cord-302756-343y63e5 55 24 support support NN cord-302756-343y63e5 55 25 [ [ -LRB- cord-302756-343y63e5 55 26 27 27 CD cord-302756-343y63e5 55 27 ] ] -RRB- cord-302756-343y63e5 55 28 . . . cord-302756-343y63e5 56 1 Regarding regard VBG cord-302756-343y63e5 56 2 anticoagulation anticoagulation NN cord-302756-343y63e5 56 3 , , , cord-302756-343y63e5 56 4 the the DT cord-302756-343y63e5 56 5 drug drug NN cord-302756-343y63e5 56 6 of of IN cord-302756-343y63e5 56 7 choice choice NN cord-302756-343y63e5 56 8 is be VBZ cord-302756-343y63e5 56 9 low low JJ cord-302756-343y63e5 56 10 molecular molecular JJ cord-302756-343y63e5 56 11 weight weight NN cord-302756-343y63e5 56 12 heparin heparin NN cord-302756-343y63e5 56 13 due due IN cord-302756-343y63e5 56 14 to to IN cord-302756-343y63e5 56 15 better well JJR cord-302756-343y63e5 56 16 bioavailability bioavailability NN cord-302756-343y63e5 56 17 and and CC cord-302756-343y63e5 56 18 ease ease NN cord-302756-343y63e5 56 19 of of IN cord-302756-343y63e5 56 20 use use NN cord-302756-343y63e5 56 21 . . . cord-302756-343y63e5 57 1 However however RB cord-302756-343y63e5 57 2 , , , cord-302756-343y63e5 57 3 in in IN cord-302756-343y63e5 57 4 patients patient NNS cord-302756-343y63e5 57 5 who who WP cord-302756-343y63e5 57 6 may may MD cord-302756-343y63e5 57 7 have have VB cord-302756-343y63e5 57 8 severe severe JJ cord-302756-343y63e5 57 9 renal renal JJ cord-302756-343y63e5 57 10 impairment impairment NN cord-302756-343y63e5 57 11 or or CC cord-302756-343y63e5 57 12 extremely extremely RB cord-302756-343y63e5 57 13 high high JJ cord-302756-343y63e5 57 14 risk risk NN cord-302756-343y63e5 57 15 of of IN cord-302756-343y63e5 57 16 bleeding bleed VBG cord-302756-343y63e5 57 17 , , , cord-302756-343y63e5 57 18 unfractionated unfractionated JJ cord-302756-343y63e5 57 19 heparin heparin NN cord-302756-343y63e5 57 20 may may MD cord-302756-343y63e5 57 21 be be VB cord-302756-343y63e5 57 22 considered consider VBN cord-302756-343y63e5 57 23 . . . cord-302756-343y63e5 58 1 Some some DT cord-302756-343y63e5 58 2 early early JJ cord-302756-343y63e5 58 3 reports report NNS cord-302756-343y63e5 58 4 suggest suggest VBP cord-302756-343y63e5 58 5 that that DT cord-302756-343y63e5 58 6 point point NN cord-302756-343y63e5 58 7 of of IN cord-302756-343y63e5 58 8 care care NN cord-302756-343y63e5 58 9 viscoelastic viscoelastic JJ cord-302756-343y63e5 58 10 tests test NNS cord-302756-343y63e5 58 11 such such JJ cord-302756-343y63e5 58 12 as as IN cord-302756-343y63e5 58 13 thrombo thrombo NN cord-302756-343y63e5 58 14 - - HYPH cord-302756-343y63e5 58 15 elastography elastography NN cord-302756-343y63e5 58 16 ( ( -LRB- cord-302756-343y63e5 58 17 TEG TEG NNP cord-302756-343y63e5 58 18 ) ) -RRB- cord-302756-343y63e5 58 19 or or CC cord-302756-343y63e5 58 20 rotational rotational JJ cord-302756-343y63e5 58 21 thrombo thrombo NNP cord-302756-343y63e5 58 22 - - HYPH cord-302756-343y63e5 58 23 elastometry elastometry NNP cord-302756-343y63e5 58 24 ( ( -LRB- cord-302756-343y63e5 58 25 ROTEM ROTEM NNP cord-302756-343y63e5 58 26 ) ) -RRB- cord-302756-343y63e5 58 27 may may MD cord-302756-343y63e5 58 28 be be VB cord-302756-343y63e5 58 29 helpful helpful JJ cord-302756-343y63e5 58 30 in in IN cord-302756-343y63e5 58 31 guiding guide VBG cord-302756-343y63e5 58 32 treatment treatment NN cord-302756-343y63e5 58 33 . . . cord-302756-343y63e5 59 1 Data datum NNS cord-302756-343y63e5 59 2 from from IN cord-302756-343y63e5 59 3 observational observational JJ cord-302756-343y63e5 59 4 studies study NNS cord-302756-343y63e5 59 5 has have VBZ cord-302756-343y63e5 59 6 shown show VBN cord-302756-343y63e5 59 7 evidence evidence NN cord-302756-343y63e5 59 8 of of IN cord-302756-343y63e5 59 9 hypercoagulability hypercoagulability NN cord-302756-343y63e5 59 10 on on IN cord-302756-343y63e5 59 11 TEG TEG NNP cord-302756-343y63e5 59 12 with with IN cord-302756-343y63e5 59 13 decreased decrease VBN cord-302756-343y63e5 59 14 ' ' `` cord-302756-343y63e5 59 15 r r NN cord-302756-343y63e5 59 16 ' ' '' cord-302756-343y63e5 59 17 and and CC cord-302756-343y63e5 59 18 ' ' `` cord-302756-343y63e5 59 19 k k XX cord-302756-343y63e5 59 20 ' ' CC cord-302756-343y63e5 59 21 times time NNS cord-302756-343y63e5 59 22 and and CC cord-302756-343y63e5 59 23 increased increase VBN cord-302756-343y63e5 59 24 maximum maximum JJ cord-302756-343y63e5 59 25 amplitudes amplitude NNS cord-302756-343y63e5 59 26 ( ( -LRB- cord-302756-343y63e5 59 27 MA MA NNP cord-302756-343y63e5 59 28 ) ) -RRB- cord-302756-343y63e5 59 29 in in IN cord-302756-343y63e5 59 30 patients patient NNS cord-302756-343y63e5 59 31 with with IN cord-302756-343y63e5 59 32 known know VBN cord-302756-343y63e5 59 33 raised raise VBN cord-302756-343y63e5 59 34 fibrinogen fibrinogen NN cord-302756-343y63e5 59 35 and and CC cord-302756-343y63e5 59 36 Ddimer Ddimer NNP cord-302756-343y63e5 59 37 levels level NNS cord-302756-343y63e5 59 38 [ [ -LRB- cord-302756-343y63e5 59 39 29 29 CD cord-302756-343y63e5 59 40 ] ] -RRB- cord-302756-343y63e5 60 1 This this DT cord-302756-343y63e5 60 2 was be VBD cord-302756-343y63e5 60 3 also also RB cord-302756-343y63e5 60 4 demonstrated demonstrate VBN cord-302756-343y63e5 60 5 with with IN cord-302756-343y63e5 60 6 the the DT cord-302756-343y63e5 60 7 ROTEM ROTEM NNP cord-302756-343y63e5 60 8 with with IN cord-302756-343y63e5 60 9 a a DT cord-302756-343y63e5 60 10 shorter short JJR cord-302756-343y63e5 60 11 clot clot NN cord-302756-343y63e5 60 12 formation formation NN cord-302756-343y63e5 60 13 time time NN cord-302756-343y63e5 60 14 and and CC cord-302756-343y63e5 60 15 high high JJ cord-302756-343y63e5 60 16 clot clot NN cord-302756-343y63e5 60 17 firmness firmness NN cord-302756-343y63e5 60 18 [ [ -LRB- cord-302756-343y63e5 60 19 30 30 CD cord-302756-343y63e5 60 20 ] ] -RRB- cord-302756-343y63e5 60 21 . . . cord-302756-343y63e5 61 1 A a DT cord-302756-343y63e5 61 2 separate separate JJ cord-302756-343y63e5 61 3 study study NN cord-302756-343y63e5 61 4 using use VBG cord-302756-343y63e5 61 5 the the DT cord-302756-343y63e5 61 6 Quantra Quantra NNP cord-302756-343y63e5 61 7 ( ( -LRB- cord-302756-343y63e5 61 8 Hemosonics Hemosonics NNP cord-302756-343y63e5 61 9 , , , cord-302756-343y63e5 61 10 Charlottesville Charlottesville NNP cord-302756-343y63e5 61 11 , , , cord-302756-343y63e5 61 12 VA VA NNP cord-302756-343y63e5 61 13 , , , cord-302756-343y63e5 61 14 USA USA NNP cord-302756-343y63e5 61 15 ) ) -RRB- cord-302756-343y63e5 61 16 again again RB cord-302756-343y63e5 61 17 demonstrated demonstrate VBD cord-302756-343y63e5 61 18 a a DT cord-302756-343y63e5 61 19 procoagulant procoagulant NN cord-302756-343y63e5 61 20 profile profile NN cord-302756-343y63e5 61 21 with with IN cord-302756-343y63e5 61 22 increased increase VBN cord-302756-343y63e5 61 23 clot clot NN cord-302756-343y63e5 61 24 strength strength NN cord-302756-343y63e5 61 25 , , , cord-302756-343y63e5 61 26 increased increase VBN cord-302756-343y63e5 61 27 platelet platelet NN cord-302756-343y63e5 61 28 and and CC cord-302756-343y63e5 61 29 fibrinogen fibrinogen NN cord-302756-343y63e5 61 30 contributions contribution NNS cord-302756-343y63e5 61 31 in in IN cord-302756-343y63e5 61 32 patients patient NNS cord-302756-343y63e5 61 33 with with IN cord-302756-343y63e5 61 34 known known JJ cord-302756-343y63e5 61 35 elevated elevated JJ cord-302756-343y63e5 61 36 D d NN cord-302756-343y63e5 61 37 - - HYPH cord-302756-343y63e5 61 38 dimer dimer NN cord-302756-343y63e5 61 39 and and CC cord-302756-343y63e5 61 40 fibrinogen fibrinogen NN cord-302756-343y63e5 61 41 levels level NNS cord-302756-343y63e5 61 42 [ [ -LRB- cord-302756-343y63e5 61 43 24 24 CD cord-302756-343y63e5 61 44 ] ] -RRB- cord-302756-343y63e5 61 45 . . . cord-302756-343y63e5 62 1 It -PRON- PRP cord-302756-343y63e5 62 2 may may MD cord-302756-343y63e5 62 3 be be VB cord-302756-343y63e5 62 4 that that IN cord-302756-343y63e5 62 5 those those DT cord-302756-343y63e5 62 6 with with IN cord-302756-343y63e5 62 7 greater great JJR cord-302756-343y63e5 62 8 hypercoagulability hypercoagulability NN cord-302756-343y63e5 62 9 have have VBP cord-302756-343y63e5 62 10 a a DT cord-302756-343y63e5 62 11 worse bad JJR cord-302756-343y63e5 62 12 outcome outcome NN cord-302756-343y63e5 62 13 . . . cord-302756-343y63e5 63 1 In in IN cord-302756-343y63e5 63 2 addition addition NN cord-302756-343y63e5 63 3 , , , cord-302756-343y63e5 63 4 there there EX cord-302756-343y63e5 63 5 may may MD cord-302756-343y63e5 63 6 be be VB cord-302756-343y63e5 63 7 a a DT cord-302756-343y63e5 63 8 possibility possibility NN cord-302756-343y63e5 63 9 of of IN cord-302756-343y63e5 63 10 using use VBG cord-302756-343y63e5 63 11 one one CD cord-302756-343y63e5 63 12 of of IN cord-302756-343y63e5 63 13 these these DT cord-302756-343y63e5 63 14 point point NN cord-302756-343y63e5 63 15 of of IN cord-302756-343y63e5 63 16 care care NN cord-302756-343y63e5 63 17 viscoelastic viscoelastic JJ cord-302756-343y63e5 63 18 tests test NNS cord-302756-343y63e5 63 19 as as IN cord-302756-343y63e5 63 20 a a DT cord-302756-343y63e5 63 21 screening screening NN cord-302756-343y63e5 63 22 tool tool NN cord-302756-343y63e5 63 23 . . . cord-302756-343y63e5 64 1 although although IN cord-302756-343y63e5 64 2 this this DT cord-302756-343y63e5 64 3 requires require VBZ cord-302756-343y63e5 64 4 a a DT cord-302756-343y63e5 64 5 great great JJ cord-302756-343y63e5 64 6 deal deal NN cord-302756-343y63e5 64 7 of of IN cord-302756-343y63e5 64 8 further further JJ cord-302756-343y63e5 64 9 research research NN cord-302756-343y63e5 64 10 . . . cord-302756-343y63e5 65 1 It -PRON- PRP cord-302756-343y63e5 65 2 may may MD cord-302756-343y63e5 65 3 also also RB cord-302756-343y63e5 65 4 be be VB cord-302756-343y63e5 65 5 that that IN cord-302756-343y63e5 65 6 these these DT cord-302756-343y63e5 65 7 tests test NNS cord-302756-343y63e5 65 8 can can MD cord-302756-343y63e5 65 9 be be VB cord-302756-343y63e5 65 10 used use VBN cord-302756-343y63e5 65 11 optimise optimise VB cord-302756-343y63e5 65 12 This this DT cord-302756-343y63e5 65 13 article article NN cord-302756-343y63e5 65 14 is be VBZ cord-302756-343y63e5 65 15 protected protect VBN cord-302756-343y63e5 65 16 by by IN cord-302756-343y63e5 65 17 copyright copyright NN cord-302756-343y63e5 65 18 . . . cord-302756-343y63e5 66 1 All all DT cord-302756-343y63e5 66 2 rights right NNS cord-302756-343y63e5 66 3 reserved reserve VBN cord-302756-343y63e5 66 4 anticoagulation anticoagulation NN cord-302756-343y63e5 66 5 therapy therapy NN cord-302756-343y63e5 66 6 , , , cord-302756-343y63e5 66 7 particularly particularly RB cord-302756-343y63e5 66 8 in in IN cord-302756-343y63e5 66 9 the the DT cord-302756-343y63e5 66 10 acute acute JJ cord-302756-343y63e5 66 11 ICU ICU NNP cord-302756-343y63e5 66 12 setting setting NN cord-302756-343y63e5 66 13 , , , cord-302756-343y63e5 66 14 although although IN cord-302756-343y63e5 66 15 this this DT cord-302756-343y63e5 66 16 again again RB cord-302756-343y63e5 66 17 needs need VBZ cord-302756-343y63e5 66 18 further further JJ cord-302756-343y63e5 66 19 research research NN cord-302756-343y63e5 66 20 . . . cord-302756-343y63e5 67 1 Overt overt JJ cord-302756-343y63e5 67 2 bleeding bleeding NN cord-302756-343y63e5 67 3 is be VBZ cord-302756-343y63e5 67 4 rare rare JJ cord-302756-343y63e5 67 5 in in IN cord-302756-343y63e5 67 6 COVID-19 covid-19 JJ cord-302756-343y63e5 67 7 patients patient NNS cord-302756-343y63e5 67 8 although although IN cord-302756-343y63e5 67 9 there there EX cord-302756-343y63e5 67 10 are be VBP cord-302756-343y63e5 67 11 patients patient NNS cord-302756-343y63e5 67 12 who who WP cord-302756-343y63e5 67 13 develop develop VBP cord-302756-343y63e5 67 14 disseminated disseminate VBN cord-302756-343y63e5 67 15 intravascular intravascular JJ cord-302756-343y63e5 67 16 coagulation coagulation NN cord-302756-343y63e5 67 17 ( ( -LRB- cord-302756-343y63e5 67 18 DIC DIC NNP cord-302756-343y63e5 67 19 ) ) -RRB- cord-302756-343y63e5 67 20 in in IN cord-302756-343y63e5 67 21 common common JJ cord-302756-343y63e5 67 22 with with IN cord-302756-343y63e5 67 23 many many JJ cord-302756-343y63e5 67 24 patients patient NNS cord-302756-343y63e5 67 25 who who WP cord-302756-343y63e5 67 26 are be VBP cord-302756-343y63e5 67 27 critically critically RB cord-302756-343y63e5 67 28 unwell unwell JJ cord-302756-343y63e5 67 29 . . . cord-302756-343y63e5 68 1 However however RB cord-302756-343y63e5 68 2 , , , cord-302756-343y63e5 68 3 heparinisation heparinisation NN cord-302756-343y63e5 68 4 may may MD cord-302756-343y63e5 68 5 be be VB cord-302756-343y63e5 68 6 difficult difficult JJ cord-302756-343y63e5 68 7 to to TO cord-302756-343y63e5 68 8 manage manage VB cord-302756-343y63e5 68 9 . . . cord-302756-343y63e5 69 1 Helms Helms NNP cord-302756-343y63e5 69 2 et et NNP cord-302756-343y63e5 69 3 al al NNP cord-302756-343y63e5 69 4 . . . cord-302756-343y63e5 70 1 recently recently RB cord-302756-343y63e5 70 2 reported report VBD cord-302756-343y63e5 70 3 that that IN cord-302756-343y63e5 70 4 96.6 96.6 CD cord-302756-343y63e5 70 5 % % NN cord-302756-343y63e5 70 6 of of IN cord-302756-343y63e5 70 7 patients patient NNS cord-302756-343y63e5 70 8 requiring require VBG cord-302756-343y63e5 70 9 renal renal JJ cord-302756-343y63e5 70 10 replacement replacement NN cord-302756-343y63e5 70 11 therapy therapy NN cord-302756-343y63e5 70 12 experienced experience VBD cord-302756-343y63e5 70 13 circuit circuit NN cord-302756-343y63e5 70 14 clotting clotting NN cord-302756-343y63e5 70 15 , , , cord-302756-343y63e5 70 16 and and CC cord-302756-343y63e5 70 17 in in IN cord-302756-343y63e5 70 18 twelve twelve CD cord-302756-343y63e5 70 19 patients patient NNS cord-302756-343y63e5 70 20 requiring require VBG cord-302756-343y63e5 70 21 extracorporeal extracorporeal JJ cord-302756-343y63e5 70 22 membrane membrane NN cord-302756-343y63e5 70 23 oxygenation oxygenation NN cord-302756-343y63e5 70 24 ( ( -LRB- cord-302756-343y63e5 70 25 ECMO ECMO NNP cord-302756-343y63e5 70 26 ) ) -RRB- cord-302756-343y63e5 70 27 , , , cord-302756-343y63e5 70 28 there there EX cord-302756-343y63e5 70 29 were be VBD cord-302756-343y63e5 70 30 three three CD cord-302756-343y63e5 70 31 thrombotic thrombotic JJ cord-302756-343y63e5 70 32 occlusions occlusion NNS cord-302756-343y63e5 70 33 of of IN cord-302756-343y63e5 70 34 the the DT cord-302756-343y63e5 70 35 centrifugal centrifugal JJ cord-302756-343y63e5 70 36 pump pump NN cord-302756-343y63e5 70 37 ( ( -LRB- cord-302756-343y63e5 70 38 in in IN cord-302756-343y63e5 70 39 two two CD cord-302756-343y63e5 70 40 patients patient NNS cord-302756-343y63e5 70 41 ) ) -RRB- cord-302756-343y63e5 70 42 requiring require VBG cord-302756-343y63e5 70 43 prompt prompt JJ cord-302756-343y63e5 70 44 pump pump NN cord-302756-343y63e5 70 45 replacement replacement NN cord-302756-343y63e5 70 46 [ [ -LRB- cord-302756-343y63e5 70 47 31 31 CD cord-302756-343y63e5 70 48 ] ] -RRB- cord-302756-343y63e5 70 49 . . . cord-302756-343y63e5 71 1 This this DT cord-302756-343y63e5 71 2 is be VBZ cord-302756-343y63e5 71 3 turn turn NN cord-302756-343y63e5 71 4 may may MD cord-302756-343y63e5 71 5 lead lead VB cord-302756-343y63e5 71 6 the the DT cord-302756-343y63e5 71 7 clinician clinician NN cord-302756-343y63e5 71 8 to to TO cord-302756-343y63e5 71 9 increase increase VB cord-302756-343y63e5 71 10 heparin heparin JJ cord-302756-343y63e5 71 11 therapy therapy NN cord-302756-343y63e5 71 12 leading lead VBG cord-302756-343y63e5 71 13 to to IN cord-302756-343y63e5 71 14 iatrogenic iatrogenic JJ cord-302756-343y63e5 71 15 bleeding bleeding NN cord-302756-343y63e5 71 16 . . . cord-302756-343y63e5 72 1 The the DT cord-302756-343y63e5 72 2 same same JJ cord-302756-343y63e5 72 3 authors author NNS cord-302756-343y63e5 72 4 found find VBD cord-302756-343y63e5 72 5 that that IN cord-302756-343y63e5 72 6 50 50 CD cord-302756-343y63e5 72 7 out out IN cord-302756-343y63e5 72 8 of of IN cord-302756-343y63e5 72 9 57 57 CD cord-302756-343y63e5 72 10 patients patient NNS cord-302756-343y63e5 72 11 tested test VBN cord-302756-343y63e5 72 12 had have VBD cord-302756-343y63e5 72 13 positive positive JJ cord-302756-343y63e5 72 14 lupus lupus NN cord-302756-343y63e5 72 15 anticoagulant anticoagulant JJ cord-302756-343y63e5 72 16 . . . cord-302756-343y63e5 73 1 Lupus lupus JJ cord-302756-343y63e5 73 2 anticoagulant anticoagulant NN cord-302756-343y63e5 73 3 is be VBZ cord-302756-343y63e5 73 4 known know VBN cord-302756-343y63e5 73 5 to to TO cord-302756-343y63e5 73 6 prolong prolong VB cord-302756-343y63e5 73 7 the the DT cord-302756-343y63e5 73 8 actibated actibate VBN cord-302756-343y63e5 73 9 partial partial JJ cord-302756-343y63e5 73 10 thromboplastin thromboplastin NNP cord-302756-343y63e5 73 11 time time NN cord-302756-343y63e5 73 12 ( ( -LRB- cord-302756-343y63e5 73 13 APTT APTT NNP cord-302756-343y63e5 73 14 ) ) -RRB- cord-302756-343y63e5 73 15 ; ; : cord-302756-343y63e5 73 16 it -PRON- PRP cord-302756-343y63e5 73 17 may may MD cord-302756-343y63e5 73 18 be be VB cord-302756-343y63e5 73 19 that that IN cord-302756-343y63e5 73 20 using use VBG cord-302756-343y63e5 73 21 the the DT cord-302756-343y63e5 73 22 APTT APTT NNP cord-302756-343y63e5 73 23 to to TO cord-302756-343y63e5 73 24 guide guide VB cord-302756-343y63e5 73 25 heparin heparin NN cord-302756-343y63e5 73 26 therapy therapy NN cord-302756-343y63e5 73 27 leads lead VBZ cord-302756-343y63e5 73 28 to to IN cord-302756-343y63e5 73 29 underdosing underdose VBG cord-302756-343y63e5 73 30 , , , cord-302756-343y63e5 73 31 leading lead VBG cord-302756-343y63e5 73 32 to to IN cord-302756-343y63e5 73 33 an an DT cord-302756-343y63e5 73 34 increase increase NN cord-302756-343y63e5 73 35 in in IN cord-302756-343y63e5 73 36 thrombosis thrombosis NN cord-302756-343y63e5 73 37 in in IN cord-302756-343y63e5 73 38 artificial artificial JJ cord-302756-343y63e5 73 39 circuits circuit NNS cord-302756-343y63e5 73 40 . . . cord-302756-343y63e5 74 1 Currently currently RB cord-302756-343y63e5 74 2 , , , cord-302756-343y63e5 74 3 the the DT cord-302756-343y63e5 74 4 only only JJ cord-302756-343y63e5 74 5 marker marker NN cord-302756-343y63e5 74 6 for for IN cord-302756-343y63e5 74 7 coagulation coagulation NN cord-302756-343y63e5 74 8 activation activation NN cord-302756-343y63e5 74 9 is be VBZ cord-302756-343y63e5 74 10 markedly markedly RB cord-302756-343y63e5 74 11 elevated elevate VBN cord-302756-343y63e5 74 12 D d NN cord-302756-343y63e5 74 13 - - HYPH cord-302756-343y63e5 74 14 dimers dimer NNS cord-302756-343y63e5 74 15 , , , cord-302756-343y63e5 74 16 which which WDT cord-302756-343y63e5 74 17 is be VBZ cord-302756-343y63e5 74 18 not not RB cord-302756-343y63e5 74 19 specific specific JJ cord-302756-343y63e5 74 20 to to IN cord-302756-343y63e5 74 21 systemic systemic JJ cord-302756-343y63e5 74 22 coagulopathy coagulopathy NN cord-302756-343y63e5 74 23 . . . cord-302756-343y63e5 75 1 Since since IN cord-302756-343y63e5 75 2 the the DT cord-302756-343y63e5 75 3 vascular vascular JJ cord-302756-343y63e5 75 4 endothelium endothelium NN cord-302756-343y63e5 75 5 is be VBZ cord-302756-343y63e5 75 6 at at IN cord-302756-343y63e5 75 7 the the DT cord-302756-343y63e5 75 8 interface interface NN cord-302756-343y63e5 75 9 of of IN cord-302756-343y63e5 75 10 coagulation coagulation NN cord-302756-343y63e5 75 11 and and CC cord-302756-343y63e5 75 12 immune immune JJ cord-302756-343y63e5 75 13 system system NN cord-302756-343y63e5 75 14 ( ( -LRB- cord-302756-343y63e5 75 15 recently recently RB cord-302756-343y63e5 75 16 termed term VBN cord-302756-343y63e5 75 17 as as IN cord-302756-343y63e5 75 18 endothelilitis endothelilitis NNP cord-302756-343y63e5 75 19 ) ) -RRB- cord-302756-343y63e5 75 20 , , , cord-302756-343y63e5 75 21 markers marker NNS cord-302756-343y63e5 75 22 of of IN cord-302756-343y63e5 75 23 endothelial endothelial JJ cord-302756-343y63e5 75 24 activation activation NN cord-302756-343y63e5 75 25 would would MD cord-302756-343y63e5 75 26 be be VB cord-302756-343y63e5 75 27 an an DT cord-302756-343y63e5 75 28 interesting interesting JJ cord-302756-343y63e5 75 29 research research NN cord-302756-343y63e5 75 30 area area NN cord-302756-343y63e5 75 31 [ [ -LRB- cord-302756-343y63e5 75 32 30 30 CD cord-302756-343y63e5 75 33 , , , cord-302756-343y63e5 75 34 32 32 CD cord-302756-343y63e5 75 35 ] ] -RRB- cord-302756-343y63e5 75 36 . . . cord-302756-343y63e5 76 1 Ruan Ruan NNP cord-302756-343y63e5 76 2 et et NNP cord-302756-343y63e5 76 3 al al NNP cord-302756-343y63e5 76 4 . . . cord-302756-343y63e5 77 1 showed show VBD cord-302756-343y63e5 77 2 that that IN cord-302756-343y63e5 77 3 interleukin-6 interleukin-6 NNP cord-302756-343y63e5 77 4 concentrations concentration NNS cord-302756-343y63e5 77 5 differed differ VBD cord-302756-343y63e5 77 6 significantly significantly RB cord-302756-343y63e5 77 7 in in IN cord-302756-343y63e5 77 8 survivors survivor NNS cord-302756-343y63e5 77 9 and and CC cord-302756-343y63e5 77 10 non non NNS cord-302756-343y63e5 77 11 - - NNS cord-302756-343y63e5 77 12 survivors survivor NNS cord-302756-343y63e5 77 13 of of IN cord-302756-343y63e5 77 14 COVID-19 COVID-19 NNP cord-302756-343y63e5 77 15 , , , cord-302756-343y63e5 77 16 with with IN cord-302756-343y63e5 77 17 non non NNS cord-302756-343y63e5 77 18 - - NNS cord-302756-343y63e5 77 19 survivors survivor NNS cord-302756-343y63e5 77 20 having have VBG cord-302756-343y63e5 77 21 almost almost RB cord-302756-343y63e5 77 22 double double JJ cord-302756-343y63e5 77 23 the the DT cord-302756-343y63e5 77 24 level level NN cord-302756-343y63e5 77 25 as as IN cord-302756-343y63e5 77 26 survivors survivor NNS cord-302756-343y63e5 77 27 [ [ -LRB- cord-302756-343y63e5 77 28 33 33 CD cord-302756-343y63e5 77 29 ] ] -RRB- cord-302756-343y63e5 77 30 . . . cord-302756-343y63e5 78 1 Ranucci Ranucci NNP cord-302756-343y63e5 78 2 et et NNP cord-302756-343y63e5 78 3 al al NNP cord-302756-343y63e5 78 4 . . . cord-302756-343y63e5 79 1 , , , cord-302756-343y63e5 79 2 discussing discuss VBG cord-302756-343y63e5 79 3 16 16 CD cord-302756-343y63e5 79 4 patients patient NNS cord-302756-343y63e5 79 5 with with IN cord-302756-343y63e5 79 6 COVID-19 COVID-19 NNP cord-302756-343y63e5 79 7 who who WP cord-302756-343y63e5 79 8 required require VBD cord-302756-343y63e5 79 9 mechanical mechanical JJ cord-302756-343y63e5 79 10 ventilation ventilation NN cord-302756-343y63e5 79 11 , , , cord-302756-343y63e5 79 12 found find VBD cord-302756-343y63e5 79 13 an an DT cord-302756-343y63e5 79 14 increase increase NN cord-302756-343y63e5 79 15 in in IN cord-302756-343y63e5 79 16 interleukin-6 interleukin-6 NNP cord-302756-343y63e5 79 17 ( ( -LRB- cord-302756-343y63e5 79 18 IL-6 IL-6 NNP cord-302756-343y63e5 79 19 ) ) -RRB- cord-302756-343y63e5 79 20 levels level NNS cord-302756-343y63e5 79 21 , , , cord-302756-343y63e5 79 22 which which WDT cord-302756-343y63e5 79 23 correlated correlate VBD cord-302756-343y63e5 79 24 with with IN cord-302756-343y63e5 79 25 increased increase VBN cord-302756-343y63e5 79 26 fibrinogen fibrinogen NN cord-302756-343y63e5 79 27 levels level NNS cord-302756-343y63e5 79 28 , , , cord-302756-343y63e5 79 29 confirming confirm VBG cord-302756-343y63e5 79 30 the the DT cord-302756-343y63e5 79 31 link link NN cord-302756-343y63e5 79 32 between between IN cord-302756-343y63e5 79 33 inflammation inflammation NN cord-302756-343y63e5 79 34 and and CC cord-302756-343y63e5 79 35 a a DT cord-302756-343y63e5 79 36 procoagulant procoagulant JJ cord-302756-343y63e5 79 37 state state NN cord-302756-343y63e5 79 38 [ [ -LRB- cord-302756-343y63e5 79 39 24 24 CD cord-302756-343y63e5 79 40 ] ] -RRB- cord-302756-343y63e5 79 41 . . . cord-302756-343y63e5 80 1 It -PRON- PRP cord-302756-343y63e5 80 2 is be VBZ cord-302756-343y63e5 80 3 vital vital JJ cord-302756-343y63e5 80 4 that that IN cord-302756-343y63e5 80 5 healthcare healthcare NN cord-302756-343y63e5 80 6 workers worker NNS cord-302756-343y63e5 80 7 who who WP cord-302756-343y63e5 80 8 deal deal VBP cord-302756-343y63e5 80 9 with with IN cord-302756-343y63e5 80 10 patients patient NNS cord-302756-343y63e5 80 11 suffering suffer VBG cord-302756-343y63e5 80 12 from from IN cord-302756-343y63e5 80 13 COVID-19 COVID-19 NNP cord-302756-343y63e5 80 14 are be VBP cord-302756-343y63e5 80 15 familiar familiar JJ cord-302756-343y63e5 80 16 with with IN cord-302756-343y63e5 80 17 the the DT cord-302756-343y63e5 80 18 spectrum spectrum NN cord-302756-343y63e5 80 19 of of IN cord-302756-343y63e5 80 20 coagulopathy coagulopathy NN cord-302756-343y63e5 80 21 in in IN cord-302756-343y63e5 80 22 this this DT cord-302756-343y63e5 80 23 disease disease NN cord-302756-343y63e5 80 24 . . . cord-302756-343y63e5 81 1 However however RB cord-302756-343y63e5 81 2 , , , cord-302756-343y63e5 81 3 there there EX cord-302756-343y63e5 81 4 remain remain VBP cord-302756-343y63e5 81 5 many many JJ cord-302756-343y63e5 81 6 questions question NNS cord-302756-343y63e5 81 7 which which WDT cord-302756-343y63e5 81 8 need need VBP cord-302756-343y63e5 81 9 to to TO cord-302756-343y63e5 81 10 be be VB cord-302756-343y63e5 81 11 answered answer VBN cord-302756-343y63e5 81 12 . . . cord-302756-343y63e5 82 1 These these DT cord-302756-343y63e5 82 2 include include VBP cord-302756-343y63e5 82 3 : : : cord-302756-343y63e5 82 4 should should MD cord-302756-343y63e5 82 5 all all DT cord-302756-343y63e5 82 6 patients patient NNS cord-302756-343y63e5 82 7 hospitalised hospitalise VBN cord-302756-343y63e5 82 8 with with IN cord-302756-343y63e5 82 9 severe severe JJ cord-302756-343y63e5 82 10 COVID-19 COVID-19 NNP cord-302756-343y63e5 82 11 be be VB cord-302756-343y63e5 82 12 treated treat VBN cord-302756-343y63e5 82 13 empirically empirically RB cord-302756-343y63e5 82 14 with with IN cord-302756-343y63e5 82 15 therapeutic therapeutic JJ cord-302756-343y63e5 82 16 anticoagulation anticoagulation NN cord-302756-343y63e5 82 17 until until IN cord-302756-343y63e5 82 18 venous venous JJ cord-302756-343y63e5 82 19 thromboembolism thromboembolism NN cord-302756-343y63e5 82 20 is be VBZ cord-302756-343y63e5 82 21 discounted discount VBN cord-302756-343y63e5 82 22 ? ? . cord-302756-343y63e5 83 1 How how WRB cord-302756-343y63e5 83 2 should should MD cord-302756-343y63e5 83 3 we -PRON- PRP cord-302756-343y63e5 83 4 manage manage VB cord-302756-343y63e5 83 5 antiocoagulation antiocoagulation NN cord-302756-343y63e5 83 6 for for IN cord-302756-343y63e5 83 7 these these DT cord-302756-343y63e5 83 8 patients patient NNS cord-302756-343y63e5 83 9 on on IN cord-302756-343y63e5 83 10 ICU ICU NNP cord-302756-343y63e5 83 11 for for IN cord-302756-343y63e5 83 12 renal renal JJ cord-302756-343y63e5 83 13 replacement replacement NN cord-302756-343y63e5 83 14 therapy therapy NN cord-302756-343y63e5 83 15 or or CC cord-302756-343y63e5 83 16 ECMO ECMO NNP cord-302756-343y63e5 83 17 ? ? . cord-302756-343y63e5 84 1 And and CC cord-302756-343y63e5 84 2 as as IN cord-302756-343y63e5 84 3 we -PRON- PRP cord-302756-343y63e5 84 4 restart restart VBP cord-302756-343y63e5 84 5 semi semi JJ cord-302756-343y63e5 84 6 - - JJ cord-302756-343y63e5 84 7 elective elective JJ cord-302756-343y63e5 84 8 surgery surgery NN cord-302756-343y63e5 84 9 should should MD cord-302756-343y63e5 84 10 we -PRON- PRP cord-302756-343y63e5 84 11 give give VB cord-302756-343y63e5 84 12 patients patient NNS cord-302756-343y63e5 84 13 subsequently subsequently RB cord-302756-343y63e5 84 14 found find VBD cord-302756-343y63e5 84 15 to to TO cord-302756-343y63e5 84 16 be be VB cord-302756-343y63e5 84 17 COVID-19 COVID-19 NNP cord-302756-343y63e5 84 18 positive positive JJ cord-302756-343y63e5 84 19 additional additional JJ cord-302756-343y63e5 84 20 thromboprophylaxis thromboprophylaxis NN cord-302756-343y63e5 84 21 ? ? . cord-302756-343y63e5 85 1 If if IN cord-302756-343y63e5 85 2 so so RB cord-302756-343y63e5 85 3 , , , cord-302756-343y63e5 85 4 for for IN cord-302756-343y63e5 85 5 how how WRB cord-302756-343y63e5 85 6 long long JJ cord-302756-343y63e5 85 7 , , , cord-302756-343y63e5 85 8 when when WRB cord-302756-343y63e5 85 9 do do VBP cord-302756-343y63e5 85 10 we -PRON- PRP cord-302756-343y63e5 85 11 think think VB cord-302756-343y63e5 85 12 the the DT cord-302756-343y63e5 85 13 additional additional JJ cord-302756-343y63e5 85 14 risk risk NN cord-302756-343y63e5 85 15 has have VBZ cord-302756-343y63e5 85 16 passed pass VBN cord-302756-343y63e5 85 17 ? ? . cord-302756-343y63e5 86 1 At at IN cord-302756-343y63e5 86 2 present present NN cord-302756-343y63e5 86 3 we -PRON- PRP cord-302756-343y63e5 86 4 simply simply RB cord-302756-343y63e5 86 5 do do VBP cord-302756-343y63e5 86 6 not not RB cord-302756-343y63e5 86 7 have have VB cord-302756-343y63e5 86 8 adequate adequate JJ cord-302756-343y63e5 86 9 answers answer NNS cord-302756-343y63e5 86 10 for for IN cord-302756-343y63e5 86 11 these these DT cord-302756-343y63e5 86 12 questions question NNS cord-302756-343y63e5 86 13 . . . cord-302756-343y63e5 86 14 . . . cord-302756-343y63e5 87 1 This this DT cord-302756-343y63e5 87 2 article article NN cord-302756-343y63e5 87 3 is be VBZ cord-302756-343y63e5 87 4 protected protect VBN cord-302756-343y63e5 87 5 by by IN cord-302756-343y63e5 87 6 copyright copyright NN cord-302756-343y63e5 87 7 . . . cord-302756-343y63e5 88 1 All all DT cord-302756-343y63e5 88 2 rights right NNS cord-302756-343y63e5 88 3 reserved reserve VBD cord-302756-343y63e5 88 4 The the DT cord-302756-343y63e5 88 5 pathogenesis pathogenesis NN cord-302756-343y63e5 88 6 and and CC cord-302756-343y63e5 88 7 treatment treatment NN cord-302756-343y63e5 88 8 of of IN cord-302756-343y63e5 88 9 the the DT cord-302756-343y63e5 88 10 ' ' `` cord-302756-343y63e5 88 11 Cytokine Cytokine NNP cord-302756-343y63e5 88 12 Storm Storm NNP cord-302756-343y63e5 88 13 ' ' '' cord-302756-343y63e5 88 14 in in IN cord-302756-343y63e5 88 15 COVID-19 COVID-19 NNP cord-302756-343y63e5 88 16 The the DT cord-302756-343y63e5 88 17 use use NN cord-302756-343y63e5 88 18 of of IN cord-302756-343y63e5 88 19 anti anti JJ cord-302756-343y63e5 88 20 - - JJ cord-302756-343y63e5 88 21 inflammatory inflammatory JJ cord-302756-343y63e5 88 22 drugs drug NNS cord-302756-343y63e5 88 23 in in IN cord-302756-343y63e5 88 24 the the DT cord-302756-343y63e5 88 25 treatment treatment NN cord-302756-343y63e5 88 26 of of IN cord-302756-343y63e5 88 27 people people NNS cord-302756-343y63e5 88 28 with with IN cord-302756-343y63e5 88 29 severe severe JJ cord-302756-343y63e5 88 30 coronavirus coronavirus NN cord-302756-343y63e5 88 31 disease disease NN cord-302756-343y63e5 88 32 2019 2019 CD cord-302756-343y63e5 88 33 ( ( -LRB- cord-302756-343y63e5 88 34 COVID-19 COVID-19 NNP cord-302756-343y63e5 88 35 ) ) -RRB- cord-302756-343y63e5 88 36 : : : cord-302756-343y63e5 88 37 the the DT cord-302756-343y63e5 88 38 perspectives perspective NNS cord-302756-343y63e5 88 39 of of IN cord-302756-343y63e5 88 40 clinical clinical JJ cord-302756-343y63e5 88 41 immunologists immunologist NNS cord-302756-343y63e5 88 42 from from IN cord-302756-343y63e5 88 43 China China NNP cord-302756-343y63e5 88 44 High high JJ cord-302756-343y63e5 88 45 incidence incidence NN cord-302756-343y63e5 88 46 of of IN cord-302756-343y63e5 88 47 venous venous JJ cord-302756-343y63e5 88 48 thromboembolic thromboembolic JJ cord-302756-343y63e5 88 49 events event NNS cord-302756-343y63e5 88 50 in in IN cord-302756-343y63e5 88 51 anticoagulated anticoagulated JJ cord-302756-343y63e5 88 52 severe severe JJ cord-302756-343y63e5 88 53 COVID-19 COVID-19 NNP cord-302756-343y63e5 88 54 patients patient NNS cord-302756-343y63e5 89 1 Anticoagulant anticoagulant JJ cord-302756-343y63e5 89 2 treatment treatment NN cord-302756-343y63e5 89 3 is be VBZ cord-302756-343y63e5 89 4 associated associate VBN cord-302756-343y63e5 89 5 with with IN cord-302756-343y63e5 89 6 decreased decrease VBN cord-302756-343y63e5 89 7 mortality mortality NN cord-302756-343y63e5 89 8 in in IN cord-302756-343y63e5 89 9 severe severe JJ cord-302756-343y63e5 89 10 coronavirus coronavirus NN cord-302756-343y63e5 89 11 disease disease NN cord-302756-343y63e5 89 12 2019 2019 CD cord-302756-343y63e5 89 13 patients patient NNS cord-302756-343y63e5 89 14 with with IN cord-302756-343y63e5 89 15 coagulopathy coagulopathy NN cord-302756-343y63e5 89 16 Incidence incidence NN cord-302756-343y63e5 89 17 of of IN cord-302756-343y63e5 89 18 thrombotic thrombotic JJ cord-302756-343y63e5 89 19 complications complication NNS cord-302756-343y63e5 89 20 in in IN cord-302756-343y63e5 89 21 critically critically RB cord-302756-343y63e5 89 22 ill ill JJ cord-302756-343y63e5 89 23 ICU ICU NNP cord-302756-343y63e5 89 24 patients patient NNS cord-302756-343y63e5 89 25 with with IN cord-302756-343y63e5 89 26 COVID-19 covid-19 JJ cord-302756-343y63e5 89 27 Prevalence prevalence NN cord-302756-343y63e5 89 28 of of IN cord-302756-343y63e5 89 29 venous venous JJ cord-302756-343y63e5 89 30 thromboembolism thromboembolism NN cord-302756-343y63e5 89 31 in in IN cord-302756-343y63e5 89 32 patients patient NNS cord-302756-343y63e5 89 33 with with IN cord-302756-343y63e5 89 34 severe severe JJ cord-302756-343y63e5 89 35 novel novel JJ cord-302756-343y63e5 89 36 coronavirus coronavirus NN cord-302756-343y63e5 89 37 pneumonia pneumonia NN cord-302756-343y63e5 89 38 Abnormal abnormal JJ cord-302756-343y63e5 89 39 coagulation coagulation NN cord-302756-343y63e5 89 40 parameters parameter NNS cord-302756-343y63e5 89 41 are be VBP cord-302756-343y63e5 89 42 associated associate VBN cord-302756-343y63e5 89 43 with with IN cord-302756-343y63e5 89 44 poor poor JJ cord-302756-343y63e5 89 45 prognosis prognosis NN cord-302756-343y63e5 89 46 in in IN cord-302756-343y63e5 89 47 patients patient NNS cord-302756-343y63e5 89 48 with with IN cord-302756-343y63e5 89 49 novel novel JJ cord-302756-343y63e5 89 50 coronavirus coronavirus NN cord-302756-343y63e5 89 51 pneumonia pneumonia NN cord-302756-343y63e5 89 52 New new JJ cord-302756-343y63e5 89 53 types type NNS cord-302756-343y63e5 89 54 of of IN cord-302756-343y63e5 89 55 clotting clotting NN cord-302756-343y63e5 89 56 factors factor NNS cord-302756-343y63e5 89 57 and and CC cord-302756-343y63e5 89 58 defence defence NN cord-302756-343y63e5 89 59 molecules molecule NNS cord-302756-343y63e5 89 60 found find VBN cord-302756-343y63e5 89 61 in in IN cord-302756-343y63e5 89 62 horseshoe horseshoe NNP cord-302756-343y63e5 89 63 crab crab NNP cord-302756-343y63e5 89 64 hemolymph hemolymph NNP cord-302756-343y63e5 89 65 : : : cord-302756-343y63e5 89 66 their -PRON- PRP$ cord-302756-343y63e5 89 67 structures structure NNS cord-302756-343y63e5 89 68 and and CC cord-302756-343y63e5 89 69 functions function NNS cord-302756-343y63e5 89 70 Thrombosis Thrombosis NNP cord-302756-343y63e5 89 71 as as IN cord-302756-343y63e5 89 72 an an DT cord-302756-343y63e5 89 73 intravascular intravascular JJ cord-302756-343y63e5 89 74 effector effector NN cord-302756-343y63e5 89 75 of of IN cord-302756-343y63e5 89 76 innate innate JJ cord-302756-343y63e5 89 77 immunity immunity NN cord-302756-343y63e5 89 78 Reincarnation reincarnation NN cord-302756-343y63e5 89 79 of of IN cord-302756-343y63e5 89 80 ancient ancient JJ cord-302756-343y63e5 89 81 links link NNS cord-302756-343y63e5 89 82 between between IN cord-302756-343y63e5 89 83 coagulation coagulation NN cord-302756-343y63e5 89 84 and and CC cord-302756-343y63e5 89 85 complement complement VB cord-302756-343y63e5 89 86 Coagulation coagulation NN cord-302756-343y63e5 89 87 factor factor NN cord-302756-343y63e5 89 88 XII XII NNP cord-302756-343y63e5 89 89 in in IN cord-302756-343y63e5 89 90 thrombosis thrombosis NN cord-302756-343y63e5 89 91 and and CC cord-302756-343y63e5 89 92 inflammation inflammation NN cord-302756-343y63e5 89 93 Platelets platelet NNS cord-302756-343y63e5 89 94 in in IN cord-302756-343y63e5 89 95 inflammation inflammation NN cord-302756-343y63e5 89 96 and and CC cord-302756-343y63e5 89 97 immunity immunity NN cord-302756-343y63e5 89 98 Accepted Accepted NNP cord-302756-343y63e5 89 99 Article Article NNP cord-302756-343y63e5 89 100 This this DT cord-302756-343y63e5 89 101 article article NN cord-302756-343y63e5 89 102 is be VBZ cord-302756-343y63e5 89 103 protected protect VBN cord-302756-343y63e5 89 104 by by IN cord-302756-343y63e5 89 105 copyright copyright NN cord-302756-343y63e5 89 106 . . . cord-302756-343y63e5 90 1 All all DT cord-302756-343y63e5 90 2 rights right NNS cord-302756-343y63e5 90 3 reserved reserve VBN cord-302756-343y63e5 90 4 Hyperinflammatory Hyperinflammatory NNP cord-302756-343y63e5 90 5 shock shock NN cord-302756-343y63e5 90 6 in in IN cord-302756-343y63e5 90 7 children child NNS cord-302756-343y63e5 90 8 during during IN cord-302756-343y63e5 90 9 COVID-19 covid-19 CD cord-302756-343y63e5 90 10 pandemic pandemic NN cord-302756-343y63e5 90 11 . . . cord-302756-343y63e5 91 1 Lancet Lancet NNP cord-302756-343y63e5 91 2 2020 2020 CD cord-302756-343y63e5 91 3 . . . cord-302756-343y63e5 92 1 Epub Epub NNP cord-302756-343y63e5 92 2 6 6 CD cord-302756-343y63e5 92 3 May May NNP cord-302756-343y63e5 92 4 Updates Updates NNPS cord-302756-343y63e5 92 5 in in IN cord-302756-343y63e5 92 6 thrombosis thrombosis NN cord-302756-343y63e5 92 7 in in IN cord-302756-343y63e5 92 8 pediatrics pediatric NNS cord-302756-343y63e5 92 9 : : : cord-302756-343y63e5 93 1 where where WRB cord-302756-343y63e5 93 2 are be VBP cord-302756-343y63e5 93 3 we -PRON- PRP cord-302756-343y63e5 93 4 after after IN cord-302756-343y63e5 93 5 20 20 CD cord-302756-343y63e5 93 6 years year NNS cord-302756-343y63e5 93 7 ? ? . cord-302756-343y63e5 94 1 COVID19 covid19 IN cord-302756-343y63e5 94 2 during during IN cord-302756-343y63e5 94 3 pregnancy pregnancy NN cord-302756-343y63e5 94 4 : : : cord-302756-343y63e5 94 5 a a DT cord-302756-343y63e5 94 6 systematic systematic JJ cord-302756-343y63e5 94 7 review review NN cord-302756-343y63e5 94 8 of of IN cord-302756-343y63e5 94 9 reported report VBN cord-302756-343y63e5 94 10 cases case NNS cord-302756-343y63e5 94 11 COVID-19 covid-19 VBP cord-302756-343y63e5 94 12 coagulopathy coagulopathy NN cord-302756-343y63e5 94 13 in in IN cord-302756-343y63e5 94 14 caucasian caucasian JJ cord-302756-343y63e5 94 15 patients patient NNS cord-302756-343y63e5 94 16 Bronchoalveolar Bronchoalveolar NNP cord-302756-343y63e5 94 17 hemostasis hemostasis NN cord-302756-343y63e5 94 18 in in IN cord-302756-343y63e5 94 19 lung lung NN cord-302756-343y63e5 94 20 injury injury NN cord-302756-343y63e5 94 21 and and CC cord-302756-343y63e5 94 22 acute acute JJ cord-302756-343y63e5 94 23 respiratory respiratory JJ cord-302756-343y63e5 94 24 distress distress NN cord-302756-343y63e5 94 25 syndrome syndrome NN cord-302756-343y63e5 94 26 Thrombocytopenia Thrombocytopenia NNP cord-302756-343y63e5 94 27 and and CC cord-302756-343y63e5 94 28 its -PRON- PRP$ cord-302756-343y63e5 94 29 association association NN cord-302756-343y63e5 94 30 with with IN cord-302756-343y63e5 94 31 mortality mortality NN cord-302756-343y63e5 94 32 in in IN cord-302756-343y63e5 94 33 patients patient NNS cord-302756-343y63e5 94 34 with with IN cord-302756-343y63e5 94 35 COVID-19 COVID-19 NNP cord-302756-343y63e5 94 36 Causal Causal NNP cord-302756-343y63e5 94 37 relationship relationship NN cord-302756-343y63e5 94 38 between between IN cord-302756-343y63e5 94 39 hyperfibrinogenemia hyperfibrinogenemia NN cord-302756-343y63e5 94 40 , , , cord-302756-343y63e5 94 41 thrombosis thrombosis NN cord-302756-343y63e5 94 42 , , , cord-302756-343y63e5 94 43 and and CC cord-302756-343y63e5 94 44 resistance resistance NN cord-302756-343y63e5 94 45 to to IN cord-302756-343y63e5 94 46 thrombolysis thrombolysis NN cord-302756-343y63e5 94 47 in in IN cord-302756-343y63e5 94 48 mice mouse NNS cord-302756-343y63e5 95 1 Pathological pathological JJ cord-302756-343y63e5 95 2 evidence evidence NN cord-302756-343y63e5 95 3 of of IN cord-302756-343y63e5 95 4 pulmonary pulmonary JJ cord-302756-343y63e5 95 5 thrombotic thrombotic JJ cord-302756-343y63e5 95 6 phenomena phenomenon NNS cord-302756-343y63e5 95 7 in in IN cord-302756-343y63e5 95 8 severe severe JJ cord-302756-343y63e5 95 9 COVID-19 COVID-19 NNP cord-302756-343y63e5 95 10 COVID-19 COVID-19 NNP cord-302756-343y63e5 95 11 pneumonia pneumonia NN cord-302756-343y63e5 95 12 : : : cord-302756-343y63e5 95 13 different different JJ cord-302756-343y63e5 95 14 respiratory respiratory JJ cord-302756-343y63e5 95 15 treatments treatment NNS cord-302756-343y63e5 95 16 for for IN cord-302756-343y63e5 95 17 different different JJ cord-302756-343y63e5 95 18 phenotypes phenotype NNS cord-302756-343y63e5 95 19 ? ? . cord-302756-343y63e5 96 1 ISTH isth JJ cord-302756-343y63e5 96 2 interim interim JJ cord-302756-343y63e5 96 3 guidance guidance NN cord-302756-343y63e5 96 4 on on IN cord-302756-343y63e5 96 5 recognition recognition NN cord-302756-343y63e5 96 6 and and CC cord-302756-343y63e5 96 7 management management NN cord-302756-343y63e5 96 8 of of IN cord-302756-343y63e5 96 9 coagulopathy coagulopathy NN cord-302756-343y63e5 96 10 in in IN cord-302756-343y63e5 96 11 COVID-19 COVID-19 NNP cord-302756-343y63e5 96 12 COVID-19 COVID-19 NNP cord-302756-343y63e5 96 13 and and CC cord-302756-343y63e5 96 14 thrombotic thrombotic JJ cord-302756-343y63e5 96 15 or or CC cord-302756-343y63e5 96 16 thromboembolic thromboembolic JJ cord-302756-343y63e5 96 17 disease disease NN cord-302756-343y63e5 96 18 : : : cord-302756-343y63e5 96 19 implications implication NNS cord-302756-343y63e5 96 20 for for IN cord-302756-343y63e5 96 21 prevention prevention NN cord-302756-343y63e5 96 22 , , , cord-302756-343y63e5 96 23 antithrombotic antithrombotic JJ cord-302756-343y63e5 96 24 therapy therapy NN cord-302756-343y63e5 96 25 , , , cord-302756-343y63e5 96 26 and and CC cord-302756-343y63e5 96 27 follow follow NN cord-302756-343y63e5 96 28 - - HYPH cord-302756-343y63e5 96 29 up up NN cord-302756-343y63e5 97 1 The the DT cord-302756-343y63e5 97 2 procoagulant procoagulant NN cord-302756-343y63e5 97 3 pattern pattern NN cord-302756-343y63e5 97 4 if if IN cord-302756-343y63e5 97 5 patients patient NNS cord-302756-343y63e5 97 6 with with IN cord-302756-343y63e5 97 7 COVID-19 covid-19 JJ cord-302756-343y63e5 97 8 acute acute JJ cord-302756-343y63e5 97 9 respiratory respiratory JJ cord-302756-343y63e5 97 10 distress distress NN cord-302756-343y63e5 97 11 syndrome syndrome NN cord-302756-343y63e5 98 1 Fibrinolytic fibrinolytic JJ cord-302756-343y63e5 98 2 abnormalities abnormality NNS cord-302756-343y63e5 98 3 in in IN cord-302756-343y63e5 98 4 acute acute JJ cord-302756-343y63e5 98 5 respiratory respiratory JJ cord-302756-343y63e5 98 6 distress distress NN cord-302756-343y63e5 98 7 syndrome syndrome NN cord-302756-343y63e5 98 8 ( ( -LRB- cord-302756-343y63e5 98 9 ARDS ARDS NNP cord-302756-343y63e5 98 10 ) ) -RRB- cord-302756-343y63e5 98 11 and and CC cord-302756-343y63e5 98 12 versatility versatility NN cord-302756-343y63e5 98 13 of of IN cord-302756-343y63e5 98 14 thrombolytic thrombolytic NN cord-302756-343y63e5 98 15 drugs drug NNS cord-302756-343y63e5 98 16 to to TO cord-302756-343y63e5 98 17 treat treat VB cord-302756-343y63e5 98 18 Accepted Accepted NNP cord-302756-343y63e5 98 19 Article Article NNP cord-302756-343y63e5 98 20 This this DT cord-302756-343y63e5 98 21 article article NN cord-302756-343y63e5 98 22 is be VBZ cord-302756-343y63e5 98 23 protected protect VBN cord-302756-343y63e5 98 24 by by IN cord-302756-343y63e5 98 25 copyright copyright NN cord-302756-343y63e5 98 26 . . . cord-302756-343y63e5 99 1 All all DT cord-302756-343y63e5 99 2 rights right NNS cord-302756-343y63e5 99 3 reserved reserve VBD cord-302756-343y63e5 99 4 COVID-19 COVID-19 NNP cord-302756-343y63e5 99 5 COVID-19 COVID-19 NNP cord-302756-343y63e5 99 6 and and CC cord-302756-343y63e5 99 7 what what WP cord-302756-343y63e5 99 8 pediatric pediatric JJ cord-302756-343y63e5 99 9 rheumatologists rheumatologist NNS cord-302756-343y63e5 99 10 should should MD cord-302756-343y63e5 99 11 know know VB cord-302756-343y63e5 99 12 : : : cord-302756-343y63e5 100 1 a a DT cord-302756-343y63e5 100 2 review review NN cord-302756-343y63e5 100 3 from from IN cord-302756-343y63e5 100 4 a a DT cord-302756-343y63e5 100 5 highly highly RB cord-302756-343y63e5 100 6 affected affected JJ cord-302756-343y63e5 100 7 country country NN cord-302756-343y63e5 100 8 Targeting target VBG cord-302756-343y63e5 100 9 complement complement JJ cord-302756-343y63e5 100 10 pathways pathway NNS cord-302756-343y63e5 100 11 in in IN cord-302756-343y63e5 100 12 polytrauma polytrauma NN cord-302756-343y63e5 100 13 - - HYPH cord-302756-343y63e5 100 14 and and CC cord-302756-343y63e5 100 15 sepsis sepsis NN cord-302756-343y63e5 100 16 - - HYPH cord-302756-343y63e5 100 17 induced induce VBN cord-302756-343y63e5 100 18 multiple multiple JJ cord-302756-343y63e5 100 19 - - HYPH cord-302756-343y63e5 100 20 organ organ NN cord-302756-343y63e5 100 21 dysfunction dysfunction NN cord-302756-343y63e5 100 22 Tissue Tissue NNP cord-302756-343y63e5 100 23 plasminogen plasminogen NN cord-302756-343y63e5 100 24 activator activator NN cord-302756-343y63e5 100 25 ( ( -LRB- cord-302756-343y63e5 100 26 tPA tPA NNP cord-302756-343y63e5 100 27 ) ) -RRB- cord-302756-343y63e5 100 28 treatment treatment NN cord-302756-343y63e5 100 29 for for IN cord-302756-343y63e5 100 30 COVID-19 covid-19 JJ cord-302756-343y63e5 100 31 associated associated JJ cord-302756-343y63e5 100 32 acute acute JJ cord-302756-343y63e5 100 33 respiratory respiratory JJ cord-302756-343y63e5 100 34 distress distress NN cord-302756-343y63e5 100 35 syndrome syndrome NN cord-302756-343y63e5 100 36 ( ( -LRB- cord-302756-343y63e5 100 37 ARDS ARDS NNP cord-302756-343y63e5 100 38 ) ) -RRB- cord-302756-343y63e5 100 39 : : : cord-302756-343y63e5 100 40 a a DT cord-302756-343y63e5 100 41 case case NN cord-302756-343y63e5 100 42 series series NN cord-302756-343y63e5 100 43 Hypercoaguability Hypercoaguability NNP cord-302756-343y63e5 100 44 of of IN cord-302756-343y63e5 100 45 COVID-19 COVID-19 NNP cord-302756-343y63e5 100 46 patients patient NNS cord-302756-343y63e5 100 47 in in IN cord-302756-343y63e5 100 48 Intensive Intensive NNP cord-302756-343y63e5 100 49 Care Care NNP cord-302756-343y63e5 100 50 Unit Unit NNP cord-302756-343y63e5 100 51 . . . cord-302756-343y63e5 101 1 A a DT cord-302756-343y63e5 101 2 report report NN cord-302756-343y63e5 101 3 of of IN cord-302756-343y63e5 101 4 thromboelastography thromboelastography NNP cord-302756-343y63e5 101 5 findings finding NNS cord-302756-343y63e5 101 6 and and CC cord-302756-343y63e5 101 7 other other JJ cord-302756-343y63e5 101 8 parameters parameter NNS cord-302756-343y63e5 101 9 of of IN cord-302756-343y63e5 101 10 hemostasis hemostasis NN cord-302756-343y63e5 102 1 COVID-19-related covid-19-related JJ cord-302756-343y63e5 102 2 severe severe JJ cord-302756-343y63e5 102 3 hypercoagulability hypercoagulability NN cord-302756-343y63e5 102 4 in in IN cord-302756-343y63e5 102 5 patients patient NNS cord-302756-343y63e5 102 6 admitted admit VBN cord-302756-343y63e5 102 7 to to IN cord-302756-343y63e5 102 8 intensive intensive JJ cord-302756-343y63e5 102 9 care care NN cord-302756-343y63e5 102 10 unit unit NN cord-302756-343y63e5 102 11 for for IN cord-302756-343y63e5 102 12 acute acute JJ cord-302756-343y63e5 102 13 respiratory respiratory JJ cord-302756-343y63e5 102 14 failure failure NN cord-302756-343y63e5 102 15 . . . cord-302756-343y63e5 103 1 Thrombosis thrombosis NN cord-302756-343y63e5 103 2 and and CC cord-302756-343y63e5 103 3 Haemostasis Haemostasis NNP cord-302756-343y63e5 103 4 2020 2020 CD cord-302756-343y63e5 103 5 High high JJ cord-302756-343y63e5 103 6 risk risk NN cord-302756-343y63e5 103 7 of of IN cord-302756-343y63e5 103 8 thrombosis thrombosis NN cord-302756-343y63e5 103 9 in in IN cord-302756-343y63e5 103 10 patients patient NNS cord-302756-343y63e5 103 11 with with IN cord-302756-343y63e5 103 12 severe severe JJ cord-302756-343y63e5 103 13 SARS SARS NNP cord-302756-343y63e5 103 14 - - HYPH cord-302756-343y63e5 103 15 CoV-2 CoV-2 NNP cord-302756-343y63e5 103 16 infection infection NN cord-302756-343y63e5 103 17 : : : cord-302756-343y63e5 103 18 a a DT cord-302756-343y63e5 103 19 multicentre multicentre NNP cord-302756-343y63e5 103 20 prospective prospective JJ cord-302756-343y63e5 103 21 cohort cohort NN cord-302756-343y63e5 103 22 study study NN cord-302756-343y63e5 103 23 . . . cord-302756-343y63e5 104 1 Intensive Intensive NNP cord-302756-343y63e5 104 2 Care Care NNP cord-302756-343y63e5 104 3 Medicine Medicine NNP cord-302756-343y63e5 104 4 2020 2020 CD cord-302756-343y63e5 104 5 . . . cord-302756-343y63e5 105 1 Epub Epub NNP cord-302756-343y63e5 105 2 4 4 CD cord-302756-343y63e5 105 3 May May NNP cord-302756-343y63e5 105 4 Endothelial endothelial JJ cord-302756-343y63e5 105 5 cell cell NN cord-302756-343y63e5 105 6 infection infection NN cord-302756-343y63e5 105 7 and and CC cord-302756-343y63e5 105 8 endotheliitis endotheliitis NN cord-302756-343y63e5 105 9 in in IN cord-302756-343y63e5 105 10 COVID-19 COVID-19 NNP cord-302756-343y63e5 105 11 Biomarkers Biomarkers NNPS cord-302756-343y63e5 105 12 of of IN cord-302756-343y63e5 105 13 endothelial endothelial JJ cord-302756-343y63e5 105 14 activation activation NN cord-302756-343y63e5 105 15 / / SYM cord-302756-343y63e5 105 16 dysfunction dysfunction NN cord-302756-343y63e5 105 17 in in IN cord-302756-343y63e5 105 18 infectious infectious JJ cord-302756-343y63e5 105 19 diseases disease NNS cord-302756-343y63e5 105 20 Clinical clinical JJ cord-302756-343y63e5 105 21 predictors predictor NNS cord-302756-343y63e5 105 22 of of IN cord-302756-343y63e5 105 23 mortality mortality NN cord-302756-343y63e5 105 24 due due IN cord-302756-343y63e5 105 25 to to IN cord-302756-343y63e5 105 26 COVID-19 COVID-19 NNP cord-302756-343y63e5 105 27 based base VBN cord-302756-343y63e5 105 28 on on IN cord-302756-343y63e5 105 29 analysis analysis NN cord-302756-343y63e5 105 30 of of IN cord-302756-343y63e5 105 31 data datum NNS cord-302756-343y63e5 105 32 of of IN cord-302756-343y63e5 105 33 150 150 CD cord-302756-343y63e5 105 34 patients patient NNS cord-302756-343y63e5 105 35 from from IN cord-302756-343y63e5 105 36 Wuhan Wuhan NNP cord-302756-343y63e5 105 37 , , , cord-302756-343y63e5 105 38 China China NNP cord-302756-343y63e5 105 39 JT JT NNP cord-302756-343y63e5 105 40 has have VBZ cord-302756-343y63e5 105 41 received receive VBN cord-302756-343y63e5 105 42 honoraria honorarium NNS cord-302756-343y63e5 105 43 from from IN cord-302756-343y63e5 105 44 Bayer Bayer NNP cord-302756-343y63e5 105 45 , , , cord-302756-343y63e5 105 46 BMS BMS NNP cord-302756-343y63e5 105 47 - - HYPH cord-302756-343y63e5 105 48 Pfizer Pfizer NNP cord-302756-343y63e5 105 49 , , , cord-302756-343y63e5 105 50 Daichii Daichii NNP cord-302756-343y63e5 105 51 - - HYPH cord-302756-343y63e5 105 52 Sankyo Sankyo NNP cord-302756-343y63e5 105 53 , , , cord-302756-343y63e5 105 54 Boehringer Boehringer NNP cord-302756-343y63e5 105 55 , , , cord-302756-343y63e5 105 56 Mitsubishi Mitsubishi NNP cord-302756-343y63e5 105 57 , , , cord-302756-343y63e5 105 58 Novo Novo NNP cord-302756-343y63e5 105 59 Nordisk Nordisk NNP cord-302756-343y63e5 105 60 , , , cord-302756-343y63e5 105 61 Octapharma Octapharma NNP cord-302756-343y63e5 105 62 , , , cord-302756-343y63e5 105 63 Amgen Amgen NNP cord-302756-343y63e5 105 64 , , , cord-302756-343y63e5 105 65 Norgine Norgine NNP cord-302756-343y63e5 105 66 , , , cord-302756-343y63e5 105 67 Alexion Alexion NNP cord-302756-343y63e5 105 68 , , , cord-302756-343y63e5 105 69 Sobi Sobi NNP cord-302756-343y63e5 105 70 , , , cord-302756-343y63e5 105 71 CSL CSL NNP cord-302756-343y63e5 105 72 - - HYPH cord-302756-343y63e5 105 73 Behring Behring NNP cord-302756-343y63e5 105 74 and and CC cord-302756-343y63e5 105 75 Roche Roche NNP cord-302756-343y63e5 105 76 - - HYPH cord-302756-343y63e5 105 77 Chugai Chugai NNP cord-302756-343y63e5 105 78 , , , cord-302756-343y63e5 105 79 none none NN cord-302756-343y63e5 105 80 of of IN cord-302756-343y63e5 105 81 which which WDT cord-302756-343y63e5 105 82 were be VBD cord-302756-343y63e5 105 83 involved involve VBN cord-302756-343y63e5 105 84 in in IN cord-302756-343y63e5 105 85 this this DT cord-302756-343y63e5 105 86 editorial editorial NN cord-302756-343y63e5 105 87 . . . cord-302756-343y63e5 106 1 SA SA NNP cord-302756-343y63e5 106 2 is be VBZ cord-302756-343y63e5 106 3 an an DT cord-302756-343y63e5 106 4 editor editor NN cord-302756-343y63e5 106 5 of of IN cord-302756-343y63e5 106 6 Anaesthesia Anaesthesia NNP cord-302756-343y63e5 106 7 . . . cord-302756-343y63e5 107 1 She -PRON- PRP cord-302756-343y63e5 107 2 has have VBZ cord-302756-343y63e5 107 3 received receive VBN cord-302756-343y63e5 107 4 research research NN cord-302756-343y63e5 107 5 funding funding NN cord-302756-343y63e5 107 6 and and CC cord-302756-343y63e5 107 7 honoraria honoraria NN cord-302756-343y63e5 107 8 from from IN cord-302756-343y63e5 107 9 Haemonetics Haemonetics NNP cord-302756-343y63e5 107 10 , , , cord-302756-343y63e5 107 11 Pharmacosmos Pharmacosmos NNP cord-302756-343y63e5 107 12 , , , cord-302756-343y63e5 107 13 Octapharma Octapharma NNP cord-302756-343y63e5 107 14 , , , cord-302756-343y63e5 107 15 CSL CSL NNP cord-302756-343y63e5 107 16 Behring Behring NNP cord-302756-343y63e5 107 17 , , , cord-302756-343y63e5 107 18 and and CC cord-302756-343y63e5 107 19 Nordic Nordic NNP cord-302756-343y63e5 107 20 Pharma Pharma NNP cord-302756-343y63e5 107 21 , , , cord-302756-343y63e5 107 22 none none NN cord-302756-343y63e5 107 23 of of IN cord-302756-343y63e5 107 24 which which WDT cord-302756-343y63e5 107 25 were be VBD cord-302756-343y63e5 107 26 involved involve VBN cord-302756-343y63e5 107 27 in in IN cord-302756-343y63e5 107 28 this this DT cord-302756-343y63e5 107 29 editorial editorial NN cord-302756-343y63e5 107 30 . . . cord-302756-343y63e5 108 1 No no DT cord-302756-343y63e5 108 2 other other JJ cord-302756-343y63e5 108 3 competing compete VBG cord-302756-343y63e5 108 4 interests interest NNS cord-302756-343y63e5 108 5 declared declare VBD cord-302756-343y63e5 108 6 . . . cord-302756-343y63e5 109 1 This this DT cord-302756-343y63e5 109 2 article article NN cord-302756-343y63e5 109 3 is be VBZ cord-302756-343y63e5 109 4 protected protect VBN cord-302756-343y63e5 109 5 by by IN cord-302756-343y63e5 109 6 copyright copyright NN cord-302756-343y63e5 109 7 . . . cord-302756-343y63e5 110 1 All all DT cord-302756-343y63e5 110 2 rights right NNS cord-302756-343y63e5 110 3 reserved reserve VBD cord-302756-343y63e5 110 4 This this DT cord-302756-343y63e5 110 5 article article NN cord-302756-343y63e5 110 6 is be VBZ cord-302756-343y63e5 110 7 protected protect VBN cord-302756-343y63e5 110 8 by by IN cord-302756-343y63e5 110 9 copyright copyright NN cord-302756-343y63e5 110 10 . . . cord-302756-343y63e5 111 1 All all DT cord-302756-343y63e5 111 2 rights right NNS cord-302756-343y63e5 111 3 reserved reserve VBN cord-302756-343y63e5 111 4 _SP