id sid tid token lemma pos cord-302115-r39ser2c 1 1 key key NN cord-302115-r39ser2c 1 2 : : : cord-302115-r39ser2c 2 1 cord-302115-r39ser2c cord-302115-r39ser2c JJ cord-302115-r39ser2c 2 2 authors author NNS cord-302115-r39ser2c 2 3 : : : cord-302115-r39ser2c 2 4 Matricardi Matricardi NNP cord-302115-r39ser2c 2 5 , , , cord-302115-r39ser2c 2 6 Paolo Paolo NNP cord-302115-r39ser2c 2 7 Maria Maria NNP cord-302115-r39ser2c 2 8 ; ; : cord-302115-r39ser2c 2 9 Dal Dal NNP cord-302115-r39ser2c 2 10 Negro Negro NNP cord-302115-r39ser2c 2 11 , , , cord-302115-r39ser2c 2 12 Roberto Roberto NNP cord-302115-r39ser2c 2 13 Walter Walter NNP cord-302115-r39ser2c 2 14 ; ; : cord-302115-r39ser2c 2 15 Nisini Nisini NNP cord-302115-r39ser2c 2 16 , , , cord-302115-r39ser2c 2 17 Roberto Roberto NNP cord-302115-r39ser2c 2 18 title title NN cord-302115-r39ser2c 2 19 : : : cord-302115-r39ser2c 2 20 The the DT cord-302115-r39ser2c 2 21 first first JJ cord-302115-r39ser2c 2 22 , , , cord-302115-r39ser2c 2 23 holistic holistic JJ cord-302115-r39ser2c 2 24 immunological immunological JJ cord-302115-r39ser2c 2 25 model model NN cord-302115-r39ser2c 2 26 of of IN cord-302115-r39ser2c 2 27 COVID‐19 covid‐19 NN cord-302115-r39ser2c 2 28 : : : cord-302115-r39ser2c 2 29 implications implication NNS cord-302115-r39ser2c 2 30 for for IN cord-302115-r39ser2c 2 31 prevention prevention NN cord-302115-r39ser2c 2 32 , , , cord-302115-r39ser2c 2 33 diagnosis diagnosis NN cord-302115-r39ser2c 2 34 , , , cord-302115-r39ser2c 2 35 and and CC cord-302115-r39ser2c 2 36 public public JJ cord-302115-r39ser2c 2 37 health health NN cord-302115-r39ser2c 2 38 measures measure NNS cord-302115-r39ser2c 2 39 date date NN cord-302115-r39ser2c 2 40 : : : cord-302115-r39ser2c 2 41 2020 2020 CD cord-302115-r39ser2c 2 42 - - HYPH cord-302115-r39ser2c 2 43 05 05 CD cord-302115-r39ser2c 2 44 - - HYPH cord-302115-r39ser2c 2 45 02 02 CD cord-302115-r39ser2c 2 46 journal journal NN cord-302115-r39ser2c 2 47 : : : cord-302115-r39ser2c 2 48 Pediatr Pediatr NNP cord-302115-r39ser2c 2 49 Allergy Allergy NNP cord-302115-r39ser2c 2 50 Immunol Immunol NNP cord-302115-r39ser2c 2 51 DOI DOI NNP cord-302115-r39ser2c 2 52 : : : cord-302115-r39ser2c 3 1 10.1111 10.1111 CD cord-302115-r39ser2c 3 2 / / SYM cord-302115-r39ser2c 3 3 pai.13271 pai.13271 XX cord-302115-r39ser2c 4 1 sha sha NNP cord-302115-r39ser2c 4 2 : : : cord-302115-r39ser2c 4 3 782edc699ba9abc492206e67ad9b3bc015a05fd6 782edc699ba9abc492206e67ad9b3bc015a05fd6 CD cord-302115-r39ser2c 4 4 doc_id doc_id NNPS cord-302115-r39ser2c 4 5 : : : cord-302115-r39ser2c 4 6 302115 302115 CD cord-302115-r39ser2c 4 7 cord_uid cord_uid NNS cord-302115-r39ser2c 4 8 : : : cord-302115-r39ser2c 5 1 r39ser2c r39ser2c NNP cord-302115-r39ser2c 6 1 The the DT cord-302115-r39ser2c 6 2 natural natural JJ cord-302115-r39ser2c 6 3 history history NN cord-302115-r39ser2c 6 4 of of IN cord-302115-r39ser2c 6 5 COVID‐19 covid‐19 NN cord-302115-r39ser2c 6 6 caused cause VBN cord-302115-r39ser2c 6 7 by by IN cord-302115-r39ser2c 6 8 SARS‐CoV‐2 SARS‐CoV‐2 NNP cord-302115-r39ser2c 6 9 is be VBZ cord-302115-r39ser2c 6 10 extremely extremely RB cord-302115-r39ser2c 6 11 variable variable JJ cord-302115-r39ser2c 6 12 , , , cord-302115-r39ser2c 6 13 ranging range VBG cord-302115-r39ser2c 6 14 from from IN cord-302115-r39ser2c 6 15 asymptomatic asymptomatic JJ cord-302115-r39ser2c 6 16 or or CC cord-302115-r39ser2c 6 17 mild mild JJ cord-302115-r39ser2c 6 18 infection infection NN cord-302115-r39ser2c 6 19 , , , cord-302115-r39ser2c 6 20 mainly mainly RB cord-302115-r39ser2c 6 21 in in IN cord-302115-r39ser2c 6 22 children child NNS cord-302115-r39ser2c 6 23 , , , cord-302115-r39ser2c 6 24 to to IN cord-302115-r39ser2c 6 25 multi‐organ multi‐organ JJ cord-302115-r39ser2c 6 26 failure failure NN cord-302115-r39ser2c 6 27 , , , cord-302115-r39ser2c 6 28 eventually eventually RB cord-302115-r39ser2c 6 29 fatal fatal JJ cord-302115-r39ser2c 6 30 , , , cord-302115-r39ser2c 6 31 mainly mainly RB cord-302115-r39ser2c 6 32 in in IN cord-302115-r39ser2c 6 33 the the DT cord-302115-r39ser2c 6 34 eldest eld JJS cord-302115-r39ser2c 6 35 . . . cord-302115-r39ser2c 7 1 We -PRON- PRP cord-302115-r39ser2c 7 2 propose propose VBP cord-302115-r39ser2c 7 3 here here RB cord-302115-r39ser2c 7 4 the the DT cord-302115-r39ser2c 7 5 first first JJ cord-302115-r39ser2c 7 6 model model NN cord-302115-r39ser2c 7 7 , , , cord-302115-r39ser2c 7 8 explaining explain VBG cord-302115-r39ser2c 7 9 how how WRB cord-302115-r39ser2c 7 10 the the DT cord-302115-r39ser2c 7 11 outcome outcome NN cord-302115-r39ser2c 7 12 of of IN cord-302115-r39ser2c 7 13 first first JJ cord-302115-r39ser2c 7 14 , , , cord-302115-r39ser2c 7 15 crucial crucial JJ cord-302115-r39ser2c 7 16 10‐15 10‐15 NN cord-302115-r39ser2c 7 17 days day NNS cord-302115-r39ser2c 7 18 after after IN cord-302115-r39ser2c 7 19 infection infection NN cord-302115-r39ser2c 7 20 , , , cord-302115-r39ser2c 7 21 hangs hang VBZ cord-302115-r39ser2c 7 22 on on IN cord-302115-r39ser2c 7 23 the the DT cord-302115-r39ser2c 7 24 balance balance NN cord-302115-r39ser2c 7 25 between between IN cord-302115-r39ser2c 7 26 the the DT cord-302115-r39ser2c 7 27 cumulative cumulative JJ cord-302115-r39ser2c 7 28 dose dose NN cord-302115-r39ser2c 7 29 of of IN cord-302115-r39ser2c 7 30 viral viral JJ cord-302115-r39ser2c 7 31 exposure exposure NN cord-302115-r39ser2c 7 32 and and CC cord-302115-r39ser2c 7 33 the the DT cord-302115-r39ser2c 7 34 efficacy efficacy NN cord-302115-r39ser2c 7 35 of of IN cord-302115-r39ser2c 7 36 the the DT cord-302115-r39ser2c 7 37 local local JJ cord-302115-r39ser2c 7 38 innate innate JJ cord-302115-r39ser2c 7 39 immune immune JJ cord-302115-r39ser2c 7 40 response response NN cord-302115-r39ser2c 7 41 ( ( -LRB- cord-302115-r39ser2c 7 42 natural natural JJ cord-302115-r39ser2c 7 43 IgA IgA NNP cord-302115-r39ser2c 7 44 and and CC cord-302115-r39ser2c 7 45 IgM IgM NNP cord-302115-r39ser2c 7 46 antibodies antibody NNS cord-302115-r39ser2c 7 47 , , , cord-302115-r39ser2c 7 48 Mannose Mannose NNP cord-302115-r39ser2c 7 49 Binding Binding NNP cord-302115-r39ser2c 7 50 Lectin Lectin NNP cord-302115-r39ser2c 7 51 ) ) -RRB- cord-302115-r39ser2c 7 52 . . . cord-302115-r39ser2c 8 1 If if IN cord-302115-r39ser2c 8 2 SARS‐CoV‐2 SARS‐CoV‐2 NNP cord-302115-r39ser2c 8 3 runs run VBZ cord-302115-r39ser2c 8 4 the the DT cord-302115-r39ser2c 8 5 blockade blockade NN cord-302115-r39ser2c 8 6 of of IN cord-302115-r39ser2c 8 7 this this DT cord-302115-r39ser2c 8 8 innate innate JJ cord-302115-r39ser2c 8 9 immunity immunity NN cord-302115-r39ser2c 8 10 and and CC cord-302115-r39ser2c 8 11 spreads spread VBZ cord-302115-r39ser2c 8 12 from from IN cord-302115-r39ser2c 8 13 the the DT cord-302115-r39ser2c 8 14 upper upper JJ cord-302115-r39ser2c 8 15 airways airway NNS cord-302115-r39ser2c 8 16 to to IN cord-302115-r39ser2c 8 17 the the DT cord-302115-r39ser2c 8 18 alveoli alveolus NNS cord-302115-r39ser2c 8 19 in in IN cord-302115-r39ser2c 8 20 the the DT cord-302115-r39ser2c 8 21 early early JJ cord-302115-r39ser2c 8 22 phases phase NNS cord-302115-r39ser2c 8 23 of of IN cord-302115-r39ser2c 8 24 the the DT cord-302115-r39ser2c 8 25 infections infection NNS cord-302115-r39ser2c 8 26 , , , cord-302115-r39ser2c 8 27 it -PRON- PRP cord-302115-r39ser2c 8 28 can can MD cord-302115-r39ser2c 8 29 replicate replicate VB cord-302115-r39ser2c 8 30 with with IN cord-302115-r39ser2c 8 31 no no DT cord-302115-r39ser2c 8 32 local local JJ cord-302115-r39ser2c 8 33 resistance resistance NN cord-302115-r39ser2c 8 34 , , , cord-302115-r39ser2c 8 35 causing cause VBG cord-302115-r39ser2c 8 36 pneumonia pneumonia NN cord-302115-r39ser2c 8 37 and and CC cord-302115-r39ser2c 8 38 releasing release VBG cord-302115-r39ser2c 8 39 high high JJ cord-302115-r39ser2c 8 40 amounts amount NNS cord-302115-r39ser2c 8 41 of of IN cord-302115-r39ser2c 8 42 antigens antigen NNS cord-302115-r39ser2c 8 43 . . . cord-302115-r39ser2c 9 1 The the DT cord-302115-r39ser2c 9 2 delayed delayed JJ cord-302115-r39ser2c 9 3 and and CC cord-302115-r39ser2c 9 4 strong strong JJ cord-302115-r39ser2c 9 5 adaptive adaptive JJ cord-302115-r39ser2c 9 6 immune immune JJ cord-302115-r39ser2c 9 7 response response NN cord-302115-r39ser2c 9 8 ( ( -LRB- cord-302115-r39ser2c 9 9 high high JJ cord-302115-r39ser2c 9 10 affinity affinity NN cord-302115-r39ser2c 9 11 IgM IgM NNP cord-302115-r39ser2c 9 12 and and CC cord-302115-r39ser2c 9 13 IgG IgG NNP cord-302115-r39ser2c 9 14 antibodies antibodies NNP cord-302115-r39ser2c 9 15 ) ) -RRB- cord-302115-r39ser2c 9 16 that that WDT cord-302115-r39ser2c 9 17 follows follow VBZ cord-302115-r39ser2c 9 18 , , , cord-302115-r39ser2c 9 19 causes cause VBZ cord-302115-r39ser2c 9 20 severe severe JJ cord-302115-r39ser2c 9 21 inflammation inflammation NN cord-302115-r39ser2c 9 22 and and CC cord-302115-r39ser2c 9 23 triggers trigger VBZ cord-302115-r39ser2c 9 24 mediator mediator NN cord-302115-r39ser2c 9 25 cascades cascade NNS cord-302115-r39ser2c 9 26 ( ( -LRB- cord-302115-r39ser2c 9 27 complement complement NN cord-302115-r39ser2c 9 28 , , , cord-302115-r39ser2c 9 29 coagulation coagulation NN cord-302115-r39ser2c 9 30 , , , cord-302115-r39ser2c 9 31 and and CC cord-302115-r39ser2c 9 32 cytokine cytokine NN cord-302115-r39ser2c 9 33 storm storm NN cord-302115-r39ser2c 9 34 ) ) -RRB- cord-302115-r39ser2c 9 35 leading lead VBG cord-302115-r39ser2c 9 36 to to IN cord-302115-r39ser2c 9 37 complications complication NNS cord-302115-r39ser2c 9 38 often often RB cord-302115-r39ser2c 9 39 requiring require VBG cord-302115-r39ser2c 9 40 intensive intensive JJ cord-302115-r39ser2c 9 41 therapy therapy NN cord-302115-r39ser2c 9 42 and and CC cord-302115-r39ser2c 9 43 being being NN cord-302115-r39ser2c 9 44 , , , cord-302115-r39ser2c 9 45 in in IN cord-302115-r39ser2c 9 46 some some DT cord-302115-r39ser2c 9 47 patients patient NNS cord-302115-r39ser2c 9 48 , , , cord-302115-r39ser2c 9 49 fatal fatal JJ cord-302115-r39ser2c 9 50 . . . cord-302115-r39ser2c 10 1 Low‐moderate low‐moderate JJ cord-302115-r39ser2c 10 2 physical physical JJ cord-302115-r39ser2c 10 3 activity activity NN cord-302115-r39ser2c 10 4 can can MD cord-302115-r39ser2c 10 5 still still RB cord-302115-r39ser2c 10 6 be be VB cord-302115-r39ser2c 10 7 recommended recommend VBN cord-302115-r39ser2c 10 8 . . . cord-302115-r39ser2c 11 1 However however RB cord-302115-r39ser2c 11 2 , , , cord-302115-r39ser2c 11 3 extreme extreme JJ cord-302115-r39ser2c 11 4 physical physical JJ cord-302115-r39ser2c 11 5 activity activity NN cord-302115-r39ser2c 11 6 and and CC cord-302115-r39ser2c 11 7 hyperventilation hyperventilation NN cord-302115-r39ser2c 11 8 during during IN cord-302115-r39ser2c 11 9 the the DT cord-302115-r39ser2c 11 10 incubation incubation NN cord-302115-r39ser2c 11 11 days day NNS cord-302115-r39ser2c 11 12 and and CC cord-302115-r39ser2c 11 13 early early JJ cord-302115-r39ser2c 11 14 stages stage NNS cord-302115-r39ser2c 11 15 of of IN cord-302115-r39ser2c 11 16 COVID‐19 covid‐19 NN cord-302115-r39ser2c 11 17 , , , cord-302115-r39ser2c 11 18 facilitates facilitate VBZ cord-302115-r39ser2c 11 19 early early JJ cord-302115-r39ser2c 11 20 direct direct JJ cord-302115-r39ser2c 11 21 penetration penetration NN cord-302115-r39ser2c 11 22 of of IN cord-302115-r39ser2c 11 23 high high JJ cord-302115-r39ser2c 11 24 numbers number NNS cord-302115-r39ser2c 11 25 of of IN cord-302115-r39ser2c 11 26 virus virus NN cord-302115-r39ser2c 11 27 particles particle NNS cord-302115-r39ser2c 11 28 in in IN cord-302115-r39ser2c 11 29 the the DT cord-302115-r39ser2c 11 30 lower low JJR cord-302115-r39ser2c 11 31 airways airway NNS cord-302115-r39ser2c 11 32 and and CC cord-302115-r39ser2c 11 33 the the DT cord-302115-r39ser2c 11 34 alveoli alveolus NNS cord-302115-r39ser2c 11 35 , , , cord-302115-r39ser2c 11 36 without without IN cord-302115-r39ser2c 11 37 impacting impact VBG cord-302115-r39ser2c 11 38 on on IN cord-302115-r39ser2c 11 39 the the DT cord-302115-r39ser2c 11 40 airway airway NN cord-302115-r39ser2c 11 41 ’s ’s POS cord-302115-r39ser2c 11 42 mucosae mucosae NNP cord-302115-r39ser2c 11 43 covered cover VBN cord-302115-r39ser2c 11 44 by by IN cord-302115-r39ser2c 11 45 neutralizing neutralize VBG cord-302115-r39ser2c 11 46 antibodies antibody NNS cord-302115-r39ser2c 11 47 . . . cord-302115-r39ser2c 12 1 This this DT cord-302115-r39ser2c 12 2 allows allow VBZ cord-302115-r39ser2c 12 3 the the DT cord-302115-r39ser2c 12 4 virus virus NN cord-302115-r39ser2c 12 5 bypassing bypass VBG cord-302115-r39ser2c 12 6 the the DT cord-302115-r39ser2c 12 7 efficient efficient JJ cord-302115-r39ser2c 12 8 immune immune JJ cord-302115-r39ser2c 12 9 barrier barrier NN cord-302115-r39ser2c 12 10 of of IN cord-302115-r39ser2c 12 11 the the DT cord-302115-r39ser2c 12 12 upper upper JJ cord-302115-r39ser2c 12 13 airways airways NNP cord-302115-r39ser2c 12 14 mucosa mucosa NN cord-302115-r39ser2c 12 15 in in IN cord-302115-r39ser2c 12 16 already already RB cord-302115-r39ser2c 12 17 infected infect VBN cord-302115-r39ser2c 12 18 , , , cord-302115-r39ser2c 12 19 young young JJ cord-302115-r39ser2c 12 20 and and CC cord-302115-r39ser2c 12 21 otherwise otherwise RB cord-302115-r39ser2c 12 22 healthy healthy JJ cord-302115-r39ser2c 12 23 athletes athlete NNS cord-302115-r39ser2c 12 24 . . . cord-302115-r39ser2c 13 1 In in IN cord-302115-r39ser2c 13 2 conclusion conclusion NN cord-302115-r39ser2c 13 3 , , , cord-302115-r39ser2c 13 4 whether whether IN cord-302115-r39ser2c 13 5 the the DT cord-302115-r39ser2c 13 6 virus virus NN cord-302115-r39ser2c 13 7 or or CC cord-302115-r39ser2c 13 8 the the DT cord-302115-r39ser2c 13 9 adaptative adaptative JJ cord-302115-r39ser2c 13 10 immune immune JJ cord-302115-r39ser2c 13 11 response response NN cord-302115-r39ser2c 13 12 reach reach VBP cord-302115-r39ser2c 13 13 the the DT cord-302115-r39ser2c 13 14 lungs lung NNS cord-302115-r39ser2c 13 15 first first RB cord-302115-r39ser2c 13 16 , , , cord-302115-r39ser2c 13 17 is be VBZ cord-302115-r39ser2c 13 18 a a DT cord-302115-r39ser2c 13 19 crucial crucial JJ cord-302115-r39ser2c 13 20 factor factor NN cord-302115-r39ser2c 13 21 deciding decide VBG cord-302115-r39ser2c 13 22 the the DT cord-302115-r39ser2c 13 23 fate fate NN cord-302115-r39ser2c 13 24 of of IN cord-302115-r39ser2c 13 25 the the DT cord-302115-r39ser2c 13 26 patient patient NN cord-302115-r39ser2c 13 27 . . . cord-302115-r39ser2c 14 1 This this DT cord-302115-r39ser2c 14 2 “ " `` cord-302115-r39ser2c 14 3 quantitative quantitative JJ cord-302115-r39ser2c 14 4 and and CC cord-302115-r39ser2c 14 5 time‐sequence time‐sequence NNP cord-302115-r39ser2c 14 6 dependent dependent JJ cord-302115-r39ser2c 14 7 ” " '' cord-302115-r39ser2c 14 8 model model NN cord-302115-r39ser2c 14 9 has have VBZ cord-302115-r39ser2c 14 10 several several JJ cord-302115-r39ser2c 14 11 implications implication NNS cord-302115-r39ser2c 14 12 for for IN cord-302115-r39ser2c 14 13 prevention prevention NN cord-302115-r39ser2c 14 14 , , , cord-302115-r39ser2c 14 15 diagnosis diagnosis NN cord-302115-r39ser2c 14 16 , , , cord-302115-r39ser2c 14 17 and and CC cord-302115-r39ser2c 14 18 therapy therapy NN cord-302115-r39ser2c 14 19 of of IN cord-302115-r39ser2c 14 20 COVID‐19 COVID‐19 NNP cord-302115-r39ser2c 14 21 at at RB cord-302115-r39ser2c 14 22 all all DT cord-302115-r39ser2c 14 23 ages age NNS cord-302115-r39ser2c 14 24 . . . cord-302115-r39ser2c 15 1 Most Most JJS cord-302115-r39ser2c 15 2 serological serological JJ cord-302115-r39ser2c 15 3 data datum NNS cord-302115-r39ser2c 15 4 currently currently RB cord-302115-r39ser2c 15 5 available available JJ cord-302115-r39ser2c 15 6 in in IN cord-302115-r39ser2c 15 7 the the DT cord-302115-r39ser2c 15 8 literature literature NN cord-302115-r39ser2c 15 9 refer refer NN cord-302115-r39ser2c 15 10 to to IN cord-302115-r39ser2c 15 11 patients patient NNS cord-302115-r39ser2c 15 12 examined examine VBN cord-302115-r39ser2c 15 13 mostly mostly RB cord-302115-r39ser2c 15 14 in in IN cord-302115-r39ser2c 15 15 the the DT cord-302115-r39ser2c 15 16 acute acute JJ cord-302115-r39ser2c 15 17 phase phase NN cord-302115-r39ser2c 15 18 of of IN cord-302115-r39ser2c 15 19 the the DT cord-302115-r39ser2c 15 20 disease disease NN cord-302115-r39ser2c 15 21 . . . cord-302115-r39ser2c 16 1 Therefore therefore RB cord-302115-r39ser2c 16 2 , , , cord-302115-r39ser2c 16 3 they -PRON- PRP cord-302115-r39ser2c 16 4 are be VBP cord-302115-r39ser2c 16 5 insufficient insufficient JJ cord-302115-r39ser2c 16 6 to to TO cord-302115-r39ser2c 16 7 exactly exactly RB cord-302115-r39ser2c 16 8 establish establish VB cord-302115-r39ser2c 16 9 durability durability NN cord-302115-r39ser2c 16 10 of of IN cord-302115-r39ser2c 16 11 the the DT cord-302115-r39ser2c 16 12 antibody antibody NN cord-302115-r39ser2c 16 13 titers titer NNS cord-302115-r39ser2c 16 14 of of IN cord-302115-r39ser2c 16 15 each each DT cord-302115-r39ser2c 16 16 isotype isotype NN cord-302115-r39ser2c 16 17 peak peak NN cord-302115-r39ser2c 16 18 when when WRB cord-302115-r39ser2c 16 19 they -PRON- PRP cord-302115-r39ser2c 16 20 eventually eventually RB cord-302115-r39ser2c 16 21 disappear disappear VBP cord-302115-r39ser2c 16 22 . . . cord-302115-r39ser2c 17 1 The the DT cord-302115-r39ser2c 17 2 levels level NNS cord-302115-r39ser2c 17 3 of of IN cord-302115-r39ser2c 17 4 serum serum NN cord-302115-r39ser2c 17 5 IgG igg NN cord-302115-r39ser2c 17 6 antibodies antibody NNS cord-302115-r39ser2c 17 7 , , , cord-302115-r39ser2c 17 8 however however RB cord-302115-r39ser2c 17 9 seems seem VBZ cord-302115-r39ser2c 17 10 to to TO cord-302115-r39ser2c 17 11 be be VB cord-302115-r39ser2c 17 12 proportional proportional JJ cord-302115-r39ser2c 17 13 to to IN cord-302115-r39ser2c 17 14 the the DT cord-302115-r39ser2c 17 15 intensity intensity NN cord-302115-r39ser2c 17 16 of of IN cord-302115-r39ser2c 17 17 the the DT cord-302115-r39ser2c 17 18 viral viral JJ cord-302115-r39ser2c 17 19 load load NN cord-302115-r39ser2c 17 20 and and CC cord-302115-r39ser2c 17 21 to to IN cord-302115-r39ser2c 17 22 the the DT cord-302115-r39ser2c 17 23 symptom symptom NN cord-302115-r39ser2c 17 24 severity severity NN cord-302115-r39ser2c 17 25 . . . cord-302115-r39ser2c 18 1 [ [ -LRB- cord-302115-r39ser2c 18 2 32 32 CD cord-302115-r39ser2c 18 3 , , , cord-302115-r39ser2c 18 4 36 36 CD cord-302115-r39ser2c 18 5 ] ] -RRB- cord-302115-r39ser2c 18 6 _SP cord-302115-r39ser2c 19 1 The the DT cord-302115-r39ser2c 19 2 efficacy efficacy NN cord-302115-r39ser2c 19 3 of of IN cord-302115-r39ser2c 19 4 specific specific JJ cord-302115-r39ser2c 19 5 Ig Ig NNP cord-302115-r39ser2c 19 6 and and CC cord-302115-r39ser2c 19 7 their -PRON- PRP$ cord-302115-r39ser2c 19 8 role role NN cord-302115-r39ser2c 19 9 in in IN cord-302115-r39ser2c 19 10 limiting limit VBG cord-302115-r39ser2c 19 11 viral viral JJ cord-302115-r39ser2c 19 12 spread spread NN cord-302115-r39ser2c 19 13 may may MD cord-302115-r39ser2c 19 14 be be VB cord-302115-r39ser2c 19 15 indirectly indirectly RB cord-302115-r39ser2c 19 16 assumed assume VBN cord-302115-r39ser2c 19 17 by by IN cord-302115-r39ser2c 19 18 observations observation NNS cord-302115-r39ser2c 19 19 demonstrating demonstrate VBG cord-302115-r39ser2c 19 20 that that IN cord-302115-r39ser2c 19 21 plasma plasma NN cord-302115-r39ser2c 19 22 from from IN cord-302115-r39ser2c 19 23 subjects subject NNS cord-302115-r39ser2c 19 24 recovered recover VBN cord-302115-r39ser2c 19 25 from from IN cord-302115-r39ser2c 19 26 COVID-19 COVID-19 NNP cord-302115-r39ser2c 19 27 showed show VBD cord-302115-r39ser2c 19 28 a a DT cord-302115-r39ser2c 19 29 therapeutic therapeutic JJ cord-302115-r39ser2c 19 30 efficacy efficacy NN cord-302115-r39ser2c 19 31 if if IN cord-302115-r39ser2c 19 32 passively passively RB cord-302115-r39ser2c 19 33 transferred transfer VBN cord-302115-r39ser2c 19 34 to to IN cord-302115-r39ser2c 19 35 patients.[37,38 patients.[37,38 NNP cord-302115-r39ser2c 19 36 ] ] -RRB- cord-302115-r39ser2c 20 1 Similar similar JJ cord-302115-r39ser2c 20 2 effectiveness effectiveness NN cord-302115-r39ser2c 20 3 had have VBD cord-302115-r39ser2c 20 4 been be VBN cord-302115-r39ser2c 20 5 This this DT cord-302115-r39ser2c 20 6 article article NN cord-302115-r39ser2c 20 7 is be VBZ cord-302115-r39ser2c 20 8 protected protect VBN cord-302115-r39ser2c 20 9 by by IN cord-302115-r39ser2c 20 10 copyright copyright NN cord-302115-r39ser2c 20 11 . . . cord-302115-r39ser2c 21 1 All all DT cord-302115-r39ser2c 21 2 rights right NNS cord-302115-r39ser2c 21 3 reserved reserve VBN cord-302115-r39ser2c 21 4 already already RB cord-302115-r39ser2c 21 5 demonstrated demonstrate VBD cord-302115-r39ser2c 21 6 for for IN cord-302115-r39ser2c 21 7 plasma plasma NN cord-302115-r39ser2c 21 8 from from IN cord-302115-r39ser2c 21 9 patients patient NNS cord-302115-r39ser2c 21 10 having have VBG cord-302115-r39ser2c 21 11 recovered recover VBN cord-302115-r39ser2c 21 12 from from IN cord-302115-r39ser2c 21 13 SARS SARS NNP cord-302115-r39ser2c 21 14 - - HYPH cord-302115-r39ser2c 21 15 CoV CoV NNP cord-302115-r39ser2c 21 16 and and CC cord-302115-r39ser2c 21 17 MERS MERS NNP cord-302115-r39ser2c 22 1 -CoV. -cov. ADD cord-302115-r39ser2c 23 1 [ [ -LRB- cord-302115-r39ser2c 23 2 39 39 CD cord-302115-r39ser2c 23 3 , , , cord-302115-r39ser2c 23 4 40 40 CD cord-302115-r39ser2c 23 5 ] ] -RRB- cord-302115-r39ser2c 24 1 Consequently consequently RB cord-302115-r39ser2c 24 2 , , , cord-302115-r39ser2c 24 3 infusion infusion NN cord-302115-r39ser2c 24 4 of of IN cord-302115-r39ser2c 24 5 plasma plasma NN cord-302115-r39ser2c 24 6 from from IN cord-302115-r39ser2c 24 7 convalescent convalescent JJ cord-302115-r39ser2c 24 8 individuals individual NNS cord-302115-r39ser2c 24 9 to to TO cord-302115-r39ser2c 24 10 critically critically RB cord-302115-r39ser2c 24 11 ill ill VB cord-302115-r39ser2c 25 1 COVID-19 covid-19 JJ cord-302115-r39ser2c 25 2 patients patient NNS cord-302115-r39ser2c 25 3 is be VBZ cord-302115-r39ser2c 25 4 a a DT cord-302115-r39ser2c 25 5 therapeutic therapeutic JJ cord-302115-r39ser2c 25 6 option option NN cord-302115-r39ser2c 25 7 that that WDT cord-302115-r39ser2c 25 8 is be VBZ cord-302115-r39ser2c 25 9 being be VBG cord-302115-r39ser2c 25 10 investigated investigate VBN cord-302115-r39ser2c 25 11 . . . cord-302115-r39ser2c 26 1 Although although IN cord-302115-r39ser2c 26 2 controlled control VBN cord-302115-r39ser2c 26 3 clinical clinical JJ cord-302115-r39ser2c 26 4 trials trial NNS cord-302115-r39ser2c 26 5 are be VBP cord-302115-r39ser2c 26 6 not not RB cord-302115-r39ser2c 26 7 yet yet RB cord-302115-r39ser2c 26 8 available available JJ cord-302115-r39ser2c 26 9 , , , cord-302115-r39ser2c 26 10 several several JJ cord-302115-r39ser2c 26 11 papers paper NNS cord-302115-r39ser2c 26 12 report report VBP cord-302115-r39ser2c 26 13 the the DT cord-302115-r39ser2c 26 14 efficacy efficacy NN cord-302115-r39ser2c 26 15 of of IN cord-302115-r39ser2c 26 16 this this DT cord-302115-r39ser2c 26 17 treatment treatment NN cord-302115-r39ser2c 26 18 and and CC cord-302115-r39ser2c 26 19 the the DT cord-302115-r39ser2c 26 20 lack lack NN cord-302115-r39ser2c 26 21 of of IN cord-302115-r39ser2c 26 22 serious serious JJ cord-302115-r39ser2c 26 23 adverse adverse JJ cord-302115-r39ser2c 26 24 events event NNS cord-302115-r39ser2c 26 25 . . . cord-302115-r39ser2c 27 1 [ [ -LRB- cord-302115-r39ser2c 27 2 41 41 CD cord-302115-r39ser2c 27 3 , , , cord-302115-r39ser2c 27 4 42 42 CD cord-302115-r39ser2c 27 5 ] ] -RRB- cord-302115-r39ser2c 27 6 Convalescent convalescent JJ cord-302115-r39ser2c 27 7 plasma plasma NN cord-302115-r39ser2c 27 8 was be VBD cord-302115-r39ser2c 27 9 administered administer VBN cord-302115-r39ser2c 27 10 in in IN cord-302115-r39ser2c 27 11 patients patient NNS cord-302115-r39ser2c 27 12 with with IN cord-302115-r39ser2c 27 13 a a DT cord-302115-r39ser2c 27 14 severe severe JJ cord-302115-r39ser2c 27 15 disease disease NN cord-302115-r39ser2c 27 16 , , , cord-302115-r39ser2c 27 17 and and CC cord-302115-r39ser2c 27 18 it -PRON- PRP cord-302115-r39ser2c 27 19 is be VBZ cord-302115-r39ser2c 27 20 unclear unclear JJ cord-302115-r39ser2c 27 21 whether whether IN cord-302115-r39ser2c 27 22 earlier early JJR cord-302115-r39ser2c 27 23 administration administration NN cord-302115-r39ser2c 27 24 might may MD cord-302115-r39ser2c 27 25 have have VB cord-302115-r39ser2c 27 26 been be VBN cord-302115-r39ser2c 27 27 associated associate VBN cord-302115-r39ser2c 27 28 with with IN cord-302115-r39ser2c 27 29 different different JJ cord-302115-r39ser2c 27 30 clinical clinical JJ cord-302115-r39ser2c 27 31 outcomes outcome NNS cord-302115-r39ser2c 27 32 [ [ -LRB- cord-302115-r39ser2c 27 33 43 43 CD cord-302115-r39ser2c 27 34 ] ] -RRB- cord-302115-r39ser2c 27 35 and and CC cord-302115-r39ser2c 27 36 with with IN cord-302115-r39ser2c 27 37 the the DT cord-302115-r39ser2c 27 38 prevention prevention NN cord-302115-r39ser2c 27 39 of of IN cord-302115-r39ser2c 27 40 respiratory respiratory JJ cord-302115-r39ser2c 27 41 distress distress NN cord-302115-r39ser2c 27 42 . . . cord-302115-r39ser2c 28 1 Only only RB cord-302115-r39ser2c 28 2 a a DT cord-302115-r39ser2c 28 3 small small JJ cord-302115-r39ser2c 28 4 proportion proportion NN cord-302115-r39ser2c 28 5 of of IN cord-302115-r39ser2c 28 6 humans human NNS cord-302115-r39ser2c 28 7 younger young JJR cord-302115-r39ser2c 28 8 than than IN cord-302115-r39ser2c 28 9 50 50 CD cord-302115-r39ser2c 28 10 , , , cord-302115-r39ser2c 28 11 among among IN cord-302115-r39ser2c 28 12 those those DT cord-302115-r39ser2c 28 13 who who WP cord-302115-r39ser2c 28 14 get get VBP cord-302115-r39ser2c 28 15 infected infect VBN cord-302115-r39ser2c 28 16 by by IN cord-302115-r39ser2c 28 17 SARS SARS NNP cord-302115-r39ser2c 28 18 - - HYPH cord-302115-r39ser2c 28 19 CoV-2 CoV-2 NNP cord-302115-r39ser2c 28 20 , , , cord-302115-r39ser2c 28 21 suffer suffer VBP cord-302115-r39ser2c 28 22 from from IN cord-302115-r39ser2c 28 23 moderate moderate JJ cord-302115-r39ser2c 28 24 and and CC cord-302115-r39ser2c 28 25 severe severe JJ cord-302115-r39ser2c 28 26 COVID-19 covid-19 NN cord-302115-r39ser2c 28 27 . . . cord-302115-r39ser2c 29 1 [ [ -LRB- cord-302115-r39ser2c 29 2 44 44 CD cord-302115-r39ser2c 29 3 - - SYM cord-302115-r39ser2c 29 4 46 46 CD cord-302115-r39ser2c 29 5 ] ] -RRB- cord-302115-r39ser2c 30 1 Among among IN cord-302115-r39ser2c 30 2 them -PRON- PRP cord-302115-r39ser2c 30 3 , , , cord-302115-r39ser2c 30 4 hospital hospital NN cord-302115-r39ser2c 30 5 doctors doctor NNS cord-302115-r39ser2c 30 6 frequently frequently RB cord-302115-r39ser2c 30 7 exposed expose VBN cord-302115-r39ser2c 30 8 to to IN cord-302115-r39ser2c 30 9 COVID-19 covid-19 JJ cord-302115-r39ser2c 30 10 patients patient NNS cord-302115-r39ser2c 30 11 are be VBP cord-302115-r39ser2c 30 12 , , , cord-302115-r39ser2c 30 13 unfortunately unfortunately RB cord-302115-r39ser2c 30 14 , , , cord-302115-r39ser2c 30 15 highly highly RB cord-302115-r39ser2c 30 16 represented represent VBN cord-302115-r39ser2c 30 17 . . . cord-302115-r39ser2c 31 1 [ [ -LRB- cord-302115-r39ser2c 31 2 47 47 CD cord-302115-r39ser2c 31 3 ] ] -RRB- cord-302115-r39ser2c 32 1 Dr. Dr. NNP cord-302115-r39ser2c 32 2 Li Li NNP cord-302115-r39ser2c 32 3 Wenliang Wenliang NNP cord-302115-r39ser2c 32 4 , , , cord-302115-r39ser2c 32 5 the the DT cord-302115-r39ser2c 32 6 first first JJ cord-302115-r39ser2c 32 7 man man NN cord-302115-r39ser2c 32 8 alerting alert VBG cord-302115-r39ser2c 32 9 China China NNP cord-302115-r39ser2c 32 10 and and CC cord-302115-r39ser2c 32 11 the the DT cord-302115-r39ser2c 32 12 World World NNP cord-302115-r39ser2c 32 13 of of IN cord-302115-r39ser2c 32 14 the the DT cord-302115-r39ser2c 32 15 new new JJ cord-302115-r39ser2c 32 16 infection infection NN cord-302115-r39ser2c 32 17 , , , cord-302115-r39ser2c 32 18 died die VBD cord-302115-r39ser2c 32 19 from from IN cord-302115-r39ser2c 32 20 COVID-19 COVID-19 NNP cord-302115-r39ser2c 32 21 at at IN cord-302115-r39ser2c 32 22 the the DT cord-302115-r39ser2c 32 23 age age NN cord-302115-r39ser2c 32 24 of of IN cord-302115-r39ser2c 32 25 33 33 CD cord-302115-r39ser2c 32 26 . . . cord-302115-r39ser2c 33 1 [ [ -LRB- cord-302115-r39ser2c 33 2 48 48 CD cord-302115-r39ser2c 33 3 ] ] -RRB- cord-302115-r39ser2c 34 1 Similarly similarly RB cord-302115-r39ser2c 34 2 , , , cord-302115-r39ser2c 34 3 Dr. Dr. NNP cord-302115-r39ser2c 34 4 Carlo Carlo NNP cord-302115-r39ser2c 34 5 Urbani Urbani NNP cord-302115-r39ser2c 34 6 , , , cord-302115-r39ser2c 34 7 i.e. i.e. FW cord-302115-r39ser2c 34 8 the the DT cord-302115-r39ser2c 34 9 first first JJ cord-302115-r39ser2c 34 10 man man NN cord-302115-r39ser2c 34 11 alerting alert VBG cord-302115-r39ser2c 34 12 the the DT cord-302115-r39ser2c 34 13 of of IN cord-302115-r39ser2c 34 14 SARS SARS NNP cord-302115-r39ser2c 34 15 - - HYPH cord-302115-r39ser2c 34 16 CoV CoV NNP cord-302115-r39ser2c 34 17 , , , cord-302115-r39ser2c 34 18 died die VBD cord-302115-r39ser2c 34 19 of of IN cord-302115-r39ser2c 34 20 SARS SARS NNP cord-302115-r39ser2c 34 21 at at IN cord-302115-r39ser2c 34 22 the the DT cord-302115-r39ser2c 34 23 age age NN cord-302115-r39ser2c 34 24 of of IN cord-302115-r39ser2c 34 25 46 46 CD cord-302115-r39ser2c 34 26 . . . cord-302115-r39ser2c 35 1 [ [ -LRB- cord-302115-r39ser2c 35 2 49 49 CD cord-302115-r39ser2c 35 3 ] ] -RRB- cord-302115-r39ser2c 36 1 Both both DT cord-302115-r39ser2c 36 2 doctors doctor NNS cord-302115-r39ser2c 36 3 cared care VBD cord-302115-r39ser2c 36 4 for for IN cord-302115-r39ser2c 36 5 weeks week NNS cord-302115-r39ser2c 36 6 patients patient NNS cord-302115-r39ser2c 36 7 with with IN cord-302115-r39ser2c 36 8 severe severe JJ cord-302115-r39ser2c 36 9 pneumonia pneumonia NN cord-302115-r39ser2c 36 10 with with IN cord-302115-r39ser2c 36 11 no no DT cord-302115-r39ser2c 36 12 personal personal JJ cord-302115-r39ser2c 36 13 protection protection NN cord-302115-r39ser2c 36 14 . . . cord-302115-r39ser2c 37 1 [ [ -LRB- cord-302115-r39ser2c 37 2 48 48 CD cord-302115-r39ser2c 37 3 , , , cord-302115-r39ser2c 37 4 49 49 CD cord-302115-r39ser2c 37 5 ] ] -RRB- cord-302115-r39ser2c 38 1 In in IN cord-302115-r39ser2c 38 2 Italy Italy NNP cord-302115-r39ser2c 38 3 , , , cord-302115-r39ser2c 38 4 114 114 CD cord-302115-r39ser2c 38 5 doctors doctor NNS cord-302115-r39ser2c 38 6 exposed expose VBN cord-302115-r39ser2c 38 7 to to IN cord-302115-r39ser2c 38 8 SARS SARS NNP cord-302115-r39ser2c 38 9 - - HYPH cord-302115-r39ser2c 38 10 CoV-2 CoV-2 NNP cord-302115-r39ser2c 38 11 , , , cord-302115-r39ser2c 38 12 have have VBP cord-302115-r39ser2c 38 13 so so RB cord-302115-r39ser2c 38 14 far far RB cord-302115-r39ser2c 38 15 ( ( -LRB- cord-302115-r39ser2c 38 16 14th 14th JJ cord-302115-r39ser2c 38 17 April April NNP cord-302115-r39ser2c 38 18 , , , cord-302115-r39ser2c 38 19 2020 2020 CD cord-302115-r39ser2c 38 20 ) ) -RRB- cord-302115-r39ser2c 38 21 died die VBD cord-302115-r39ser2c 38 22 of of IN cord-302115-r39ser2c 38 23 COVID COVID NNP cord-302115-r39ser2c 38 24 . . . cord-302115-r39ser2c 39 1 [ [ -LRB- cord-302115-r39ser2c 39 2 50 50 CD cord-302115-r39ser2c 39 3 ] ] -RRB- cord-302115-r39ser2c 40 1 The the DT cord-302115-r39ser2c 40 2 case case NN cord-302115-r39ser2c 40 3 fatality fatality NN cord-302115-r39ser2c 40 4 ratio ratio NN cord-302115-r39ser2c 40 5 among among IN cord-302115-r39ser2c 40 6 doctors doctor NNS cord-302115-r39ser2c 40 7 working work VBG cord-302115-r39ser2c 40 8 in in IN cord-302115-r39ser2c 40 9 hospitals hospital NNS cord-302115-r39ser2c 40 10 and and CC cord-302115-r39ser2c 40 11 caring care VBG cord-302115-r39ser2c 40 12 patients patient NNS cord-302115-r39ser2c 40 13 developing develop VBG cord-302115-r39ser2c 40 14 severe severe JJ cord-302115-r39ser2c 40 15 COVID-19 covid-19 NN cord-302115-r39ser2c 40 16 has have VBZ cord-302115-r39ser2c 40 17 been be VBN cord-302115-r39ser2c 40 18 therefore therefore RB cord-302115-r39ser2c 40 19 much much RB cord-302115-r39ser2c 40 20 higher high JJR cord-302115-r39ser2c 40 21 than than IN cord-302115-r39ser2c 40 22 among among IN cord-302115-r39ser2c 40 23 their -PRON- PRP$ cord-302115-r39ser2c 40 24 age age NN cord-302115-r39ser2c 40 25 and and CC cord-302115-r39ser2c 40 26 gender gender NN cord-302115-r39ser2c 40 27 matched match VBN cord-302115-r39ser2c 40 28 peers peer NNS cord-302115-r39ser2c 40 29 . . . cord-302115-r39ser2c 41 1 [ [ -LRB- cord-302115-r39ser2c 41 2 50 50 CD cord-302115-r39ser2c 41 3 , , , cord-302115-r39ser2c 41 4 51 51 CD cord-302115-r39ser2c 41 5 ] ] -RRB- cord-302115-r39ser2c 42 1 ( ( -LRB- cord-302115-r39ser2c 42 2 Table-1 Table-1 NNP cord-302115-r39ser2c 42 3 _SP cord-302115-r39ser2c 42 4 Observations Observations NNP cord-302115-r39ser2c 42 5 in in IN cord-302115-r39ser2c 42 6 previous previous JJ cord-302115-r39ser2c 42 7 viral viral JJ cord-302115-r39ser2c 42 8 epidemics epidemic NNS cord-302115-r39ser2c 42 9 , , , cord-302115-r39ser2c 42 10 further further RB cord-302115-r39ser2c 42 11 clarify clarify VB cord-302115-r39ser2c 42 12 this this DT cord-302115-r39ser2c 42 13 aspect aspect NN cord-302115-r39ser2c 42 14 . . . cord-302115-r39ser2c 43 1 The the DT cord-302115-r39ser2c 43 2 reliability reliability NN cord-302115-r39ser2c 43 3 of of IN cord-302115-r39ser2c 43 4 high high JJ cord-302115-r39ser2c 43 5 viral viral JJ cord-302115-r39ser2c 43 6 loads load NNS cord-302115-r39ser2c 43 7 in in IN cord-302115-r39ser2c 43 8 nasopharyngeal nasopharyngeal JJ cord-302115-r39ser2c 43 9 specimens specimen NNS cord-302115-r39ser2c 43 10 as as IN cord-302115-r39ser2c 43 11 a a DT cord-302115-r39ser2c 43 12 prognostic prognostic JJ cord-302115-r39ser2c 43 13 indicator indicator NN cord-302115-r39ser2c 43 14 of of IN cord-302115-r39ser2c 43 15 respiratory respiratory JJ cord-302115-r39ser2c 43 16 failure failure NN cord-302115-r39ser2c 43 17 or or CC cord-302115-r39ser2c 43 18 mortality mortality NN cord-302115-r39ser2c 43 19 , , , cord-302115-r39ser2c 43 20 with with IN cord-302115-r39ser2c 43 21 or or CC cord-302115-r39ser2c 43 22 without without IN cord-302115-r39ser2c 43 23 a a DT cord-302115-r39ser2c 43 24 high high JJ cord-302115-r39ser2c 43 25 viral viral JJ cord-302115-r39ser2c 43 26 load load NN cord-302115-r39ser2c 43 27 in in IN cord-302115-r39ser2c 43 28 serum serum NN cord-302115-r39ser2c 43 29 , , , cord-302115-r39ser2c 43 30 has have VBZ cord-302115-r39ser2c 43 31 been be VBN cord-302115-r39ser2c 43 32 previously previously RB cord-302115-r39ser2c 43 33 characterized characterize VBN cord-302115-r39ser2c 43 34 in in IN cord-302115-r39ser2c 43 35 SARS SARS NNP cord-302115-r39ser2c 43 36 . . . cord-302115-r39ser2c 44 1 [ [ -LRB- cord-302115-r39ser2c 44 2 52 52 CD cord-302115-r39ser2c 44 3 ] ] -RRB- cord-302115-r39ser2c 45 1 A a DT cord-302115-r39ser2c 45 2 link link NN cord-302115-r39ser2c 45 3 has have VBZ cord-302115-r39ser2c 45 4 been be VBN cord-302115-r39ser2c 45 5 established establish VBN cord-302115-r39ser2c 45 6 between between IN cord-302115-r39ser2c 45 7 the the DT cord-302115-r39ser2c 45 8 initial initial JJ cord-302115-r39ser2c 45 9 dose dose NN cord-302115-r39ser2c 45 10 and and CC cord-302115-r39ser2c 45 11 subsequent subsequent JJ cord-302115-r39ser2c 45 12 severity severity NN cord-302115-r39ser2c 45 13 of of IN cord-302115-r39ser2c 45 14 the the DT cord-302115-r39ser2c 45 15 disease disease NN cord-302115-r39ser2c 45 16 to to IN cord-302115-r39ser2c 45 17 the the DT cord-302115-r39ser2c 45 18 1918 1918 CD cord-302115-r39ser2c 45 19 - - SYM cord-302115-r39ser2c 45 20 19 19 CD cord-302115-r39ser2c 45 21 Spanish spanish JJ cord-302115-r39ser2c 45 22 Flu Flu NNP cord-302115-r39ser2c 45 23 pandemic pandemic NN cord-302115-r39ser2c 45 24 . . . cord-302115-r39ser2c 46 1 It -PRON- PRP cord-302115-r39ser2c 46 2 was be VBD cord-302115-r39ser2c 46 3 demonstrated demonstrate VBN cord-302115-r39ser2c 46 4 by by IN cord-302115-r39ser2c 46 5 simulation simulation NN cord-302115-r39ser2c 46 6 models model NNS cord-302115-r39ser2c 46 7 that that IN cord-302115-r39ser2c 46 8 the the DT cord-302115-r39ser2c 46 9 number number NN cord-302115-r39ser2c 46 10 of of IN cord-302115-r39ser2c 46 11 This this DT cord-302115-r39ser2c 46 12 article article NN cord-302115-r39ser2c 46 13 is be VBZ cord-302115-r39ser2c 46 14 protected protect VBN cord-302115-r39ser2c 46 15 by by IN cord-302115-r39ser2c 46 16 copyright copyright NN cord-302115-r39ser2c 46 17 . . . cord-302115-r39ser2c 47 1 All all DT cord-302115-r39ser2c 47 2 rights right NNS cord-302115-r39ser2c 47 3 reserved reserve VBD cord-302115-r39ser2c 47 4 simultaneous simultaneous JJ cord-302115-r39ser2c 47 5 contacts contact NNS cord-302115-r39ser2c 47 6 a a DT cord-302115-r39ser2c 47 7 susceptible susceptible JJ cord-302115-r39ser2c 47 8 person person NN cord-302115-r39ser2c 47 9 has have VBZ cord-302115-r39ser2c 47 10 with with IN cord-302115-r39ser2c 47 11 infectious infectious JJ cord-302115-r39ser2c 47 12 ones one NNS cord-302115-r39ser2c 47 13 are be VBP cord-302115-r39ser2c 47 14 correlated correlate VBN cord-302115-r39ser2c 47 15 with with IN cord-302115-r39ser2c 47 16 the the DT cord-302115-r39ser2c 47 17 infectious infectious JJ cord-302115-r39ser2c 47 18 dose dose NN cord-302115-r39ser2c 47 19 ; ; : cord-302115-r39ser2c 47 20 that that IN cord-302115-r39ser2c 47 21 severe severe JJ cord-302115-r39ser2c 47 22 cases case NNS cord-302115-r39ser2c 47 23 of of IN cord-302115-r39ser2c 47 24 influenza influenza NN cord-302115-r39ser2c 47 25 result result NN cord-302115-r39ser2c 47 26 from from IN cord-302115-r39ser2c 47 27 higher high JJR cord-302115-r39ser2c 47 28 infectious infectious JJ cord-302115-r39ser2c 47 29 doses dose NNS cord-302115-r39ser2c 47 30 of of IN cord-302115-r39ser2c 47 31 the the DT cord-302115-r39ser2c 47 32 virus virus NN cord-302115-r39ser2c 47 33 ; ; : cord-302115-r39ser2c 47 34 and and CC cord-302115-r39ser2c 47 35 that that IN cord-302115-r39ser2c 47 36 a a DT cord-302115-r39ser2c 47 37 susceptible susceptible JJ cord-302115-r39ser2c 47 38 person person NN cord-302115-r39ser2c 47 39 can can MD cord-302115-r39ser2c 47 40 be be VB cord-302115-r39ser2c 47 41 easily easily RB cord-302115-r39ser2c 47 42 exposed expose VBN cord-302115-r39ser2c 47 43 to to IN cord-302115-r39ser2c 47 44 very very RB cord-302115-r39ser2c 47 45 high high JJ cord-302115-r39ser2c 47 46 infectious infectious JJ cord-302115-r39ser2c 47 47 doses dose NNS cord-302115-r39ser2c 47 48 of of IN cord-302115-r39ser2c 47 49 influenza influenza NN cord-302115-r39ser2c 47 50 in in IN cord-302115-r39ser2c 47 51 over over RB cord-302115-r39ser2c 47 52 - - HYPH cord-302115-r39ser2c 47 53 crowded crowd VBN cord-302115-r39ser2c 47 54 places place NNS cord-302115-r39ser2c 47 55 . . . cord-302115-r39ser2c 48 1 [ [ -LRB- cord-302115-r39ser2c 48 2 53 53 CD cord-302115-r39ser2c 48 3 ] ] -RRB- cord-302115-r39ser2c 48 4 The the DT cord-302115-r39ser2c 48 5 viral viral JJ cord-302115-r39ser2c 48 6 replication replication NN cord-302115-r39ser2c 48 7 is be VBZ cord-302115-r39ser2c 48 8 more more RBR cord-302115-r39ser2c 48 9 active active JJ cord-302115-r39ser2c 48 10 and and CC cord-302115-r39ser2c 48 11 prolonged prolong VBN cord-302115-r39ser2c 48 12 in in IN cord-302115-r39ser2c 48 13 patients patient NNS cord-302115-r39ser2c 48 14 suffering suffer VBG cord-302115-r39ser2c 48 15 from from IN cord-302115-r39ser2c 48 16 severe severe JJ cord-302115-r39ser2c 48 17 influenza influenza NN cord-302115-r39ser2c 48 18 . . . cord-302115-r39ser2c 49 1 Viral viral JJ cord-302115-r39ser2c 49 2 clearance clearance NN cord-302115-r39ser2c 49 3 is be VBZ cord-302115-r39ser2c 49 4 slow slow JJ cord-302115-r39ser2c 49 5 when when WRB cord-302115-r39ser2c 49 6 host host NN cord-302115-r39ser2c 49 7 defenses defense NNS cord-302115-r39ser2c 49 8 are be VBP cord-302115-r39ser2c 49 9 weakened weaken VBN cord-302115-r39ser2c 49 10 , , , cord-302115-r39ser2c 49 11 however however RB cord-302115-r39ser2c 49 12 it -PRON- PRP cord-302115-r39ser2c 49 13 is be VBZ cord-302115-r39ser2c 49 14 enhanced enhance VBN cord-302115-r39ser2c 49 15 when when WRB cord-302115-r39ser2c 49 16 antivirals antiviral NNS cord-302115-r39ser2c 49 17 start start VBP cord-302115-r39ser2c 49 18 within within IN cord-302115-r39ser2c 49 19 the the DT cord-302115-r39ser2c 49 20 first first JJ cord-302115-r39ser2c 49 21 4 4 CD cord-302115-r39ser2c 49 22 days day NNS cord-302115-r39ser2c 49 23 of of IN cord-302115-r39ser2c 49 24 illness illness NN cord-302115-r39ser2c 49 25 . . . cord-302115-r39ser2c 50 1 [ [ -LRB- cord-302115-r39ser2c 50 2 54 54 CD cord-302115-r39ser2c 50 3 ] ] -RRB- cord-302115-r39ser2c 51 1 Among among IN cord-302115-r39ser2c 51 2 over over IN cord-302115-r39ser2c 51 3 70 70 CD cord-302115-r39ser2c 51 4 thousand thousand CD cord-302115-r39ser2c 51 5 Chinese Chinese NNPS cord-302115-r39ser2c 51 6 with with IN cord-302115-r39ser2c 51 7 COVID-19 COVID-19 NNP cord-302115-r39ser2c 51 8 , , , cord-302115-r39ser2c 51 9 most most JJS cord-302115-r39ser2c 51 10 were be VBD cord-302115-r39ser2c 51 11 aged age VBN cord-302115-r39ser2c 51 12 over over IN cord-302115-r39ser2c 51 13 30 30 CD cord-302115-r39ser2c 51 14 years year NNS cord-302115-r39ser2c 51 15 ( ( -LRB- cord-302115-r39ser2c 51 16 90 90 CD cord-302115-r39ser2c 51 17 % % NN cord-302115-r39ser2c 51 18 ) ) -RRB- cord-302115-r39ser2c 51 19 , , , cord-302115-r39ser2c 51 20 while while IN cord-302115-r39ser2c 51 21 only only RB cord-302115-r39ser2c 51 22 1 1 CD cord-302115-r39ser2c 51 23 % % NN cord-302115-r39ser2c 51 24 were be VBD cord-302115-r39ser2c 51 25 aged aged JJ cord-302115-r39ser2c 51 26 9 9 CD cord-302115-r39ser2c 51 27 years year NNS cord-302115-r39ser2c 51 28 or or CC cord-302115-r39ser2c 51 29 younger young JJR cord-302115-r39ser2c 51 30 , , , cord-302115-r39ser2c 51 31 1 1 CD cord-302115-r39ser2c 51 32 % % NN cord-302115-r39ser2c 51 33 were be VBD cord-302115-r39ser2c 51 34 aged age VBN cord-302115-r39ser2c 51 35 10 10 CD cord-302115-r39ser2c 51 36 to to TO cord-302115-r39ser2c 51 37 19 19 CD cord-302115-r39ser2c 51 38 years year NNS cord-302115-r39ser2c 51 39 an an DT cord-302115-r39ser2c 51 40 8 8 CD cord-302115-r39ser2c 51 41 % % NN cord-302115-r39ser2c 51 42 aged age VBN cord-302115-r39ser2c 51 43 20 20 CD cord-302115-r39ser2c 51 44 to to TO cord-302115-r39ser2c 51 45 29 29 CD cord-302115-r39ser2c 51 46 years year NNS cord-302115-r39ser2c 51 47 . . . cord-302115-r39ser2c 52 1 [ [ -LRB- cord-302115-r39ser2c 52 2 55 55 CD cord-302115-r39ser2c 52 3 ] ] -RRB- cord-302115-r39ser2c 53 1 Moreover moreover RB cord-302115-r39ser2c 53 2 , , , cord-302115-r39ser2c 53 3 most most JJS cord-302115-r39ser2c 53 4 of of IN cord-302115-r39ser2c 53 5 the the DT cord-302115-r39ser2c 53 6 relatively relatively RB cord-302115-r39ser2c 53 7 few few JJ cord-302115-r39ser2c 53 8 pediatric pediatric JJ cord-302115-r39ser2c 53 9 cases case NNS cord-302115-r39ser2c 53 10 were be VBD cord-302115-r39ser2c 53 11 classified classify VBN cord-302115-r39ser2c 53 12 as as IN cord-302115-r39ser2c 53 13 mild mild JJ cord-302115-r39ser2c 53 14 ( ( -LRB- cord-302115-r39ser2c 53 15 81 81 CD cord-302115-r39ser2c 53 16 % % NN cord-302115-r39ser2c 53 17 ) ) -RRB- cord-302115-r39ser2c 53 18 , , , cord-302115-r39ser2c 53 19 only only RB cord-302115-r39ser2c 53 20 14 14 CD cord-302115-r39ser2c 53 21 % % NN cord-302115-r39ser2c 53 22 severe severe JJ cord-302115-r39ser2c 53 23 and and CC cord-302115-r39ser2c 53 24 5 5 CD cord-302115-r39ser2c 53 25 % % NN cord-302115-r39ser2c 53 26 critical critical JJ cord-302115-r39ser2c 53 27 . . . cord-302115-r39ser2c 54 1 [ [ -LRB- cord-302115-r39ser2c 54 2 _SP cord-302115-r39ser2c 54 3 This this DT cord-302115-r39ser2c 54 4 article article NN cord-302115-r39ser2c 54 5 is be VBZ cord-302115-r39ser2c 54 6 protected protect VBN cord-302115-r39ser2c 54 7 by by IN cord-302115-r39ser2c 54 8 copyright copyright NN cord-302115-r39ser2c 54 9 . . . cord-302115-r39ser2c 55 1 All all DT cord-302115-r39ser2c 55 2 rights right NNS cord-302115-r39ser2c 55 3 reserved reserve VBN cord-302115-r39ser2c 56 1 COVID-19 covid-19 JJ cord-302115-r39ser2c 56 2 mortality mortality NN cord-302115-r39ser2c 56 3 has have VBZ cord-302115-r39ser2c 56 4 been be VBN cord-302115-r39ser2c 56 5 lower low JJR cord-302115-r39ser2c 56 6 among among IN cord-302115-r39ser2c 56 7 Chinese chinese JJ cord-302115-r39ser2c 56 8 females female NNS cord-302115-r39ser2c 56 9 than than IN cord-302115-r39ser2c 56 10 males male NNS cord-302115-r39ser2c 56 11 . . . cord-302115-r39ser2c 57 1 [ [ -LRB- cord-302115-r39ser2c 57 2 59 59 CD cord-302115-r39ser2c 57 3 ] ] -RRB- cord-302115-r39ser2c 58 1 In in IN cord-302115-r39ser2c 58 2 Italy Italy NNP cord-302115-r39ser2c 58 3 , , , cord-302115-r39ser2c 58 4 mortality mortality NN cord-302115-r39ser2c 58 5 and and CC cord-302115-r39ser2c 58 6 hospitalization hospitalization NN cord-302115-r39ser2c 58 7 rates rate NNS cord-302115-r39ser2c 58 8 have have VBP cord-302115-r39ser2c 58 9 been be VBN cord-302115-r39ser2c 58 10 also also RB cord-302115-r39ser2c 58 11 more more RBR cord-302115-r39ser2c 58 12 frequent frequent JJ cord-302115-r39ser2c 58 13 among among IN cord-302115-r39ser2c 58 14 males male NNS cord-302115-r39ser2c 58 15 than than IN cord-302115-r39ser2c 58 16 among among IN cord-302115-r39ser2c 58 17 females female NNS cord-302115-r39ser2c 58 18 . . . cord-302115-r39ser2c 59 1 [ [ -LRB- cord-302115-r39ser2c 59 2 60 60 CD cord-302115-r39ser2c 59 3 ] ] -RRB- cord-302115-r39ser2c 60 1 Moreover moreover RB cord-302115-r39ser2c 60 2 , , , cord-302115-r39ser2c 60 3 patients patient NNS cord-302115-r39ser2c 60 4 with with IN cord-302115-r39ser2c 60 5 blood blood NN cord-302115-r39ser2c 60 6 group group NN cord-302115-r39ser2c 60 7 0 0 NFP cord-302115-r39ser2c 60 8 and and CC cord-302115-r39ser2c 60 9 A a DT cord-302115-r39ser2c 60 10 have have VBP cord-302115-r39ser2c 60 11 slightly slightly RB cord-302115-r39ser2c 60 12 lower low JJR cord-302115-r39ser2c 60 13 and and CC cord-302115-r39ser2c 60 14 a a DT cord-302115-r39ser2c 60 15 slightly slightly RB cord-302115-r39ser2c 60 16 higher high JJR cord-302115-r39ser2c 60 17 risk risk NN cord-302115-r39ser2c 60 18 , , , cord-302115-r39ser2c 60 19 _SP cord-302115-r39ser2c 61 1 The the DT cord-302115-r39ser2c 61 2 first first JJ cord-302115-r39ser2c 61 3 diagnosis diagnosis NN cord-302115-r39ser2c 61 4 of of IN cord-302115-r39ser2c 61 5 COVID-19 COVID-19 NNP cord-302115-r39ser2c 61 6 in in IN cord-302115-r39ser2c 61 7 Europe Europe NNP cord-302115-r39ser2c 61 8 has have VBZ cord-302115-r39ser2c 61 9 been be VBN cord-302115-r39ser2c 61 10 confirmed confirm VBN cord-302115-r39ser2c 61 11 in in IN cord-302115-r39ser2c 61 12 a a DT cord-302115-r39ser2c 61 13 38 38 CD cord-302115-r39ser2c 61 14 year year NN cord-302115-r39ser2c 61 15 - - HYPH cord-302115-r39ser2c 61 16 old old JJ cord-302115-r39ser2c 61 17 Italian italian JJ cord-302115-r39ser2c 61 18 healthy healthy JJ cord-302115-r39ser2c 61 19 male male NN cord-302115-r39ser2c 61 20 who who WP cord-302115-r39ser2c 61 21 regularly regularly RB cord-302115-r39ser2c 61 22 participated participate VBD cord-302115-r39ser2c 61 23 in in IN cord-302115-r39ser2c 61 24 running run VBG cord-302115-r39ser2c 61 25 events event NNS cord-302115-r39ser2c 61 26 and and CC cord-302115-r39ser2c 61 27 soccer soccer NN cord-302115-r39ser2c 61 28 games game NNS cord-302115-r39ser2c 61 29 . . . cord-302115-r39ser2c 62 1 One one CD cord-302115-r39ser2c 62 2 day day NN cord-302115-r39ser2c 62 3 before before IN cord-302115-r39ser2c 62 4 starting start VBG cord-302115-r39ser2c 62 5 COVID-19 covid-19 JJ cord-302115-r39ser2c 62 6 symptoms symptom NNS cord-302115-r39ser2c 62 7 , , , cord-302115-r39ser2c 62 8 he -PRON- PRP cord-302115-r39ser2c 62 9 had have VBD cord-302115-r39ser2c 62 10 been be VBN cord-302115-r39ser2c 62 11 training train VBG cord-302115-r39ser2c 62 12 sport sport NN cord-302115-r39ser2c 62 13 . . . cord-302115-r39ser2c 63 1 The the DT cord-302115-r39ser2c 63 2 time time NN cord-302115-r39ser2c 63 3 - - HYPH cord-302115-r39ser2c 63 4 lapse lapse NN cord-302115-r39ser2c 63 5 between between IN cord-302115-r39ser2c 63 6 the the DT cord-302115-r39ser2c 63 7 onset onset NN cord-302115-r39ser2c 63 8 of of IN cord-302115-r39ser2c 63 9 upper upper JJ cord-302115-r39ser2c 63 10 airways airway NNS cord-302115-r39ser2c 63 11 symptoms symptom NNS cord-302115-r39ser2c 63 12 and and CC cord-302115-r39ser2c 63 13 pneumonia pneumonia NN cord-302115-r39ser2c 63 14 was be VBD cord-302115-r39ser2c 63 15 2 2 CD cord-302115-r39ser2c 63 16 days day NNS cord-302115-r39ser2c 63 17 only only RB cord-302115-r39ser2c 63 18 . . . cord-302115-r39ser2c 64 1 Only only RB cord-302115-r39ser2c 64 2 4 4 CD cord-302115-r39ser2c 64 3 days day NNS cord-302115-r39ser2c 64 4 after after IN cord-302115-r39ser2c 64 5 the the DT cord-302115-r39ser2c 64 6 onset onset NN cord-302115-r39ser2c 64 7 of of IN cord-302115-r39ser2c 64 8 COVID-19 COVID-19 NNP cord-302115-r39ser2c 64 9 , , , cord-302115-r39ser2c 64 10 the the DT cord-302115-r39ser2c 64 11 patient patient NN cord-302115-r39ser2c 64 12 was be VBD cord-302115-r39ser2c 64 13 admitted admit VBN cord-302115-r39ser2c 64 14 to to IN cord-302115-r39ser2c 64 15 the the DT cord-302115-r39ser2c 64 16 intensive intensive JJ cord-302115-r39ser2c 64 17 care care NN cord-302115-r39ser2c 64 18 unit unit NN cord-302115-r39ser2c 64 19 of of IN cord-302115-r39ser2c 64 20 the the DT cord-302115-r39ser2c 64 21 Policlinico Policlinico NNP cord-302115-r39ser2c 64 22 San San NNP cord-302115-r39ser2c 64 23 Matteo Matteo NNP cord-302115-r39ser2c 64 24 in in IN cord-302115-r39ser2c 64 25 Pavia Pavia NNP cord-302115-r39ser2c 64 26 because because IN cord-302115-r39ser2c 64 27 of of IN cord-302115-r39ser2c 64 28 respiratory respiratory JJ cord-302115-r39ser2c 64 29 failure failure NN cord-302115-r39ser2c 64 30 . . . cord-302115-r39ser2c 65 1 After after IN cord-302115-r39ser2c 65 2 weeks week NNS cord-302115-r39ser2c 65 3 of of IN cord-302115-r39ser2c 65 4 intubation intubation NN cord-302115-r39ser2c 65 5 and and CC cord-302115-r39ser2c 65 6 supportive supportive JJ cord-302115-r39ser2c 65 7 treatment treatment NN cord-302115-r39ser2c 65 8 , , , cord-302115-r39ser2c 65 9 the the DT cord-302115-r39ser2c 65 10 patient patient NN cord-302115-r39ser2c 65 11 luckily luckily RB cord-302115-r39ser2c 65 12 recovered recover VBD cord-302115-r39ser2c 65 13 and and CC cord-302115-r39ser2c 65 14 could could MD cord-302115-r39ser2c 65 15 be be VB cord-302115-r39ser2c 65 16 discharged discharge VBN cord-302115-r39ser2c 65 17 in in IN cord-302115-r39ser2c 65 18 good good JJ cord-302115-r39ser2c 65 19 conditions condition NNS cord-302115-r39ser2c 65 20 . . . cord-302115-r39ser2c 66 1 The the DT cord-302115-r39ser2c 66 2 Italian italian JJ cord-302115-r39ser2c 66 3 first first JJ cord-302115-r39ser2c 66 4 COVID-19 COVID-19 NNP cord-302115-r39ser2c 66 5 case case NN cord-302115-r39ser2c 66 6 is be VBZ cord-302115-r39ser2c 66 7 worldwide worldwide RB cord-302115-r39ser2c 66 8 famous famous JJ cord-302115-r39ser2c 66 9 but but CC cord-302115-r39ser2c 66 10 , , , cord-302115-r39ser2c 66 11 surprisingly surprisingly RB cord-302115-r39ser2c 66 12 , , , cord-302115-r39ser2c 66 13 no no DT cord-302115-r39ser2c 66 14 official official JJ cord-302115-r39ser2c 66 15 study study NN cord-302115-r39ser2c 66 16 on on IN cord-302115-r39ser2c 66 17 it -PRON- PRP cord-302115-r39ser2c 66 18 has have VBZ cord-302115-r39ser2c 66 19 been be VBN cord-302115-r39ser2c 66 20 so so RB cord-302115-r39ser2c 66 21 far far RB cord-302115-r39ser2c 66 22 published publish VBN cord-302115-r39ser2c 66 23 . . . cord-302115-r39ser2c 67 1 The the DT cord-302115-r39ser2c 67 2 example example NN cord-302115-r39ser2c 67 3 of of IN cord-302115-r39ser2c 67 4 this this DT cord-302115-r39ser2c 67 5 physically physically RB cord-302115-r39ser2c 67 6 active active JJ cord-302115-r39ser2c 67 7 , , , cord-302115-r39ser2c 67 8 young young JJ cord-302115-r39ser2c 67 9 patient patient NN cord-302115-r39ser2c 67 10 offers offer VBZ cord-302115-r39ser2c 67 11 room room NN cord-302115-r39ser2c 67 12 for for IN cord-302115-r39ser2c 67 13 reasoning reason VBG cord-302115-r39ser2c 67 14 with with IN cord-302115-r39ser2c 67 15 regard regard NN cord-302115-r39ser2c 67 16 to to IN cord-302115-r39ser2c 67 17 the the DT cord-302115-r39ser2c 67 18 importance importance NN cord-302115-r39ser2c 67 19 of of IN cord-302115-r39ser2c 67 20 sport sport NN cord-302115-r39ser2c 67 21 for for IN cord-302115-r39ser2c 67 22 virus virus NN cord-302115-r39ser2c 67 23 transmission transmission NN cord-302115-r39ser2c 67 24 and and CC cord-302115-r39ser2c 67 25 course course NN cord-302115-r39ser2c 67 26 of of IN cord-302115-r39ser2c 67 27 disease disease NN cord-302115-r39ser2c 67 28 . . . cord-302115-r39ser2c 68 1 Indeed indeed RB cord-302115-r39ser2c 68 2 , , , cord-302115-r39ser2c 68 3 other other JJ cord-302115-r39ser2c 68 4 cases case NNS cord-302115-r39ser2c 68 5 of of IN cord-302115-r39ser2c 68 6 COVID-19 covid-19 CD cord-302115-r39ser2c 68 7 in in IN cord-302115-r39ser2c 68 8 ( ( -LRB- cord-302115-r39ser2c 68 9 semi- semi- NN cord-302115-r39ser2c 68 10 ) ) -RRB- cord-302115-r39ser2c 68 11 professional professional JJ cord-302115-r39ser2c 68 12 athletes athlete NNS cord-302115-r39ser2c 68 13 have have VBP cord-302115-r39ser2c 68 14 been be VBN cord-302115-r39ser2c 68 15 described describe VBN cord-302115-r39ser2c 68 16 . . . cord-302115-r39ser2c 69 1 The the DT cord-302115-r39ser2c 69 2 pattern pattern NN cord-302115-r39ser2c 69 3 of of IN cord-302115-r39ser2c 69 4 breathing breathing NN cord-302115-r39ser2c 69 5 during during IN cord-302115-r39ser2c 69 6 strenuous strenuous JJ cord-302115-r39ser2c 69 7 exercise exercise NN cord-302115-r39ser2c 69 8 changes change NNS cord-302115-r39ser2c 69 9 dramatically dramatically RB cord-302115-r39ser2c 69 10 by by IN cord-302115-r39ser2c 69 11 a a DT cord-302115-r39ser2c 69 12 tremendous tremendous JJ cord-302115-r39ser2c 69 13 increase increase NN cord-302115-r39ser2c 69 14 of of IN cord-302115-r39ser2c 69 15 ventilation ventilation NN cord-302115-r39ser2c 69 16 ( ( -LRB- cord-302115-r39ser2c 69 17 i.e. i.e. FW cord-302115-r39ser2c 69 18 : : : cord-302115-r39ser2c 69 19 inspiratory inspiratory JJ cord-302115-r39ser2c 69 20 and and CC cord-302115-r39ser2c 69 21 expiratory expiratory JJ cord-302115-r39ser2c 69 22 volumes volume NNS cord-302115-r39ser2c 69 23 of of IN cord-302115-r39ser2c 69 24 air air NN cord-302115-r39ser2c 69 25 ) ) -RRB- cord-302115-r39ser2c 69 26 , , , cord-302115-r39ser2c 69 27 and and CC cord-302115-r39ser2c 69 28 of of IN cord-302115-r39ser2c 69 29 alveolar alveolar JJ cord-302115-r39ser2c 69 30 ventilation ventilation NN cord-302115-r39ser2c 69 31 in in IN cord-302115-r39ser2c 69 32 particular particular JJ cord-302115-r39ser2c 69 33 . . . cord-302115-r39ser2c 70 1 Obviously obviously RB cord-302115-r39ser2c 70 2 , , , cord-302115-r39ser2c 70 3 these these DT cord-302115-r39ser2c 70 4 changes change NNS cord-302115-r39ser2c 70 5 mostly mostly RB cord-302115-r39ser2c 70 6 attain attain JJ cord-302115-r39ser2c 70 7 to to IN cord-302115-r39ser2c 70 8 whatever whatever WDT cord-302115-r39ser2c 70 9 kind kind NN cord-302115-r39ser2c 70 10 of of IN cord-302115-r39ser2c 70 11 runners runner NNS cord-302115-r39ser2c 70 12 belonging belong VBG cord-302115-r39ser2c 70 13 to to IN cord-302115-r39ser2c 70 14 all all DT cord-302115-r39ser2c 70 15 sport sport NN cord-302115-r39ser2c 70 16 disciplines discipline NNS cord-302115-r39ser2c 70 17 , , , cord-302115-r39ser2c 70 18 being be VBG cord-302115-r39ser2c 70 19 semi semi JJ cord-302115-r39ser2c 70 20 - - JJ cord-302115-r39ser2c 70 21 professional professional JJ cord-302115-r39ser2c 70 22 and and CC cord-302115-r39ser2c 70 23 professional professional JJ cord-302115-r39ser2c 70 24 athletes athlete NNS cord-302115-r39ser2c 70 25 particularly particularly RB cord-302115-r39ser2c 70 26 exposed expose VBN cord-302115-r39ser2c 70 27 ( ( -LRB- cord-302115-r39ser2c 70 28 such such JJ cord-302115-r39ser2c 70 29 as as RB cord-302115-r39ser2c 70 30 much much RB cord-302115-r39ser2c 70 31 more more JJR cord-302115-r39ser2c 70 32 than than IN cord-302115-r39ser2c 70 33 individuals individual NNS cord-302115-r39ser2c 70 34 of of IN cord-302115-r39ser2c 70 35 common common JJ cord-302115-r39ser2c 70 36 population population NN cord-302115-r39ser2c 70 37 ) ) -RRB- cord-302115-r39ser2c 70 38 due due IN cord-302115-r39ser2c 70 39 to to IN cord-302115-r39ser2c 70 40 their -PRON- PRP$ cord-302115-r39ser2c 70 41 frequent frequent JJ cord-302115-r39ser2c 70 42 practice practice NN cord-302115-r39ser2c 70 43 of of IN cord-302115-r39ser2c 70 44 extreme extreme JJ cord-302115-r39ser2c 70 45 and and CC cord-302115-r39ser2c 70 46 long long RB cord-302115-r39ser2c 70 47 - - HYPH cord-302115-r39ser2c 70 48 lasting last VBG cord-302115-r39ser2c 70 49 exercise exercise NN cord-302115-r39ser2c 70 50 . . . cord-302115-r39ser2c 71 1 Furthermore furthermore RB cord-302115-r39ser2c 71 2 , , , cord-302115-r39ser2c 71 3 the the DT cord-302115-r39ser2c 71 4 majority majority NN cord-302115-r39ser2c 71 5 of of IN cord-302115-r39ser2c 71 6 these these DT cord-302115-r39ser2c 71 7 athletes athlete NNS cord-302115-r39ser2c 71 8 have have VBP cord-302115-r39ser2c 71 9 their -PRON- PRP$ cord-302115-r39ser2c 71 10 lungs lung NNS cord-302115-r39ser2c 71 11 that that WDT cord-302115-r39ser2c 71 12 usually usually RB cord-302115-r39ser2c 71 13 work work VBP cord-302115-r39ser2c 71 14 in in IN cord-302115-r39ser2c 71 15 perfect perfect JJ cord-302115-r39ser2c 71 16 physiological physiological JJ cord-302115-r39ser2c 71 17 conditions condition NNS cord-302115-r39ser2c 71 18 , , , cord-302115-r39ser2c 71 19 such such JJ cord-302115-r39ser2c 71 20 as as IN cord-302115-r39ser2c 71 21 very very RB cord-302115-r39ser2c 71 22 close close JJ cord-302115-r39ser2c 71 23 to to IN cord-302115-r39ser2c 71 24 those those DT cord-302115-r39ser2c 71 25 of of IN cord-302115-r39ser2c 71 26 the the DT cord-302115-r39ser2c 71 27 " " `` cord-302115-r39ser2c 71 28 ideal ideal JJ cord-302115-r39ser2c 71 29 lung lung NN cord-302115-r39ser2c 71 30 " " '' cord-302115-r39ser2c 71 31 . . . cord-302115-r39ser2c 72 1 In in IN cord-302115-r39ser2c 72 2 other other JJ cord-302115-r39ser2c 72 3 words word NNS cord-302115-r39ser2c 72 4 , , , cord-302115-r39ser2c 72 5 in in IN cord-302115-r39ser2c 72 6 the the DT cord-302115-r39ser2c 72 7 absence absence NN cord-302115-r39ser2c 72 8 of of IN cord-302115-r39ser2c 72 9 any any DT cord-302115-r39ser2c 72 10 anatomical anatomical JJ cord-302115-r39ser2c 72 11 or or CC cord-302115-r39ser2c 72 12 physiological physiological JJ cord-302115-r39ser2c 72 13 factor factor NN cord-302115-r39ser2c 72 14 causing cause VBG cord-302115-r39ser2c 72 15 a a DT cord-302115-r39ser2c 72 16 significant significant JJ cord-302115-r39ser2c 72 17 unevenness unevenness NN cord-302115-r39ser2c 72 18 in in IN cord-302115-r39ser2c 72 19 distribution distribution NN cord-302115-r39ser2c 72 20 of of IN cord-302115-r39ser2c 72 21 their -PRON- PRP$ cord-302115-r39ser2c 72 22 alveolar alveolar NN cord-302115-r39ser2c 72 23 ventilation ventilation NN cord-302115-r39ser2c 72 24 . . . cord-302115-r39ser2c 73 1 Paradoxically paradoxically RB cord-302115-r39ser2c 73 2 , , , cord-302115-r39ser2c 73 3 these these DT cord-302115-r39ser2c 73 4 pre pre JJ cord-302115-r39ser2c 73 5 - - JJ cord-302115-r39ser2c 73 6 existing exist VBG cord-302115-r39ser2c 73 7 ideal ideal NN cord-302115-r39ser2c 73 8 This this DT cord-302115-r39ser2c 73 9 article article NN cord-302115-r39ser2c 73 10 is be VBZ cord-302115-r39ser2c 73 11 protected protect VBN cord-302115-r39ser2c 73 12 by by IN cord-302115-r39ser2c 73 13 copyright copyright NN cord-302115-r39ser2c 73 14 . . . cord-302115-r39ser2c 74 1 All all DT cord-302115-r39ser2c 74 2 rights right NNS cord-302115-r39ser2c 74 3 reserved reserve VBN cord-302115-r39ser2c 74 4 conditions condition NNS cord-302115-r39ser2c 74 5 significantly significantly RB cord-302115-r39ser2c 74 6 favor favor VBP cord-302115-r39ser2c 74 7 the the DT cord-302115-r39ser2c 74 8 deep deep JJ cord-302115-r39ser2c 74 9 inhalation inhalation NN cord-302115-r39ser2c 74 10 of of IN cord-302115-r39ser2c 74 11 several several JJ cord-302115-r39ser2c 74 12 irritants irritant NNS cord-302115-r39ser2c 74 13 , , , cord-302115-r39ser2c 74 14 allergens allergen NNS cord-302115-r39ser2c 74 15 , , , cord-302115-r39ser2c 74 16 infectious infectious JJ cord-302115-r39ser2c 74 17 agents agent NNS cord-302115-r39ser2c 74 18 . . . cord-302115-r39ser2c 75 1 Even even RB cord-302115-r39ser2c 75 2 the the DT cord-302115-r39ser2c 75 3 SARS SARS NNP cord-302115-r39ser2c 75 4 - - HYPH cord-302115-r39ser2c 75 5 CoV-2 CoV-2 NNP cord-302115-r39ser2c 75 6 can can MD cord-302115-r39ser2c 75 7 then then RB cord-302115-r39ser2c 75 8 spread spread VB cord-302115-r39ser2c 75 9 more more RBR cord-302115-r39ser2c 75 10 easily easily RB cord-302115-r39ser2c 75 11 to to IN cord-302115-r39ser2c 75 12 the the DT cord-302115-r39ser2c 75 13 deepest deep JJS cord-302115-r39ser2c 75 14 areas area NNS cord-302115-r39ser2c 75 15 of of IN cord-302115-r39ser2c 75 16 the the DT cord-302115-r39ser2c 75 17 lungs lung NNS cord-302115-r39ser2c 75 18 ( ( -LRB- cord-302115-r39ser2c 75 19 alveolar alveolar JJ cord-302115-r39ser2c 75 20 bronchioles bronchiole NNS cord-302115-r39ser2c 75 21 and and CC cord-302115-r39ser2c 75 22 alveoli alveolus NNS cord-302115-r39ser2c 75 23 ) ) -RRB- cord-302115-r39ser2c 75 24 during during IN cord-302115-r39ser2c 75 25 strenuous strenuous JJ cord-302115-r39ser2c 75 26 exercise exercise NN cord-302115-r39ser2c 75 27 , , , cord-302115-r39ser2c 75 28 and and CC cord-302115-r39ser2c 75 29 there there EX cord-302115-r39ser2c 75 30 starts start VBZ cord-302115-r39ser2c 75 31 its -PRON- PRP$ cord-302115-r39ser2c 75 32 aggressive aggressive JJ cord-302115-r39ser2c 75 33 action action NN cord-302115-r39ser2c 75 34 . . . cord-302115-r39ser2c 76 1 Not not RB cord-302115-r39ser2c 76 2 by by IN cord-302115-r39ser2c 76 3 chance chance NN cord-302115-r39ser2c 76 4 , , , cord-302115-r39ser2c 76 5 a a DT cord-302115-r39ser2c 76 6 great great JJ cord-302115-r39ser2c 76 7 proportion proportion NN cord-302115-r39ser2c 76 8 of of IN cord-302115-r39ser2c 76 9 professional professional JJ cord-302115-r39ser2c 76 10 football football NN cord-302115-r39ser2c 76 11 players player NNS cord-302115-r39ser2c 76 12 claimed claim VBD cord-302115-r39ser2c 76 13 the the DT cord-302115-r39ser2c 76 14 occurrence occurrence NN cord-302115-r39ser2c 76 15 of of IN cord-302115-r39ser2c 76 16 fever fever NN cord-302115-r39ser2c 76 17 , , , cord-302115-r39ser2c 76 18 dry dry JJ cord-302115-r39ser2c 76 19 cough cough NN cord-302115-r39ser2c 76 20 and and CC cord-302115-r39ser2c 76 21 malaise malaise NN cord-302115-r39ser2c 76 22 ( ( -LRB- cord-302115-r39ser2c 76 23 and and CC cord-302115-r39ser2c 76 24 dyspnea dyspnea NN cord-302115-r39ser2c 76 25 in in IN cord-302115-r39ser2c 76 26 some some DT cord-302115-r39ser2c 76 27 cases case NNS cord-302115-r39ser2c 76 28 ) ) -RRB- cord-302115-r39ser2c 76 29 immediately immediately RB cord-302115-r39ser2c 76 30 after after RB cord-302115-r39ser2c 76 31 , , , cord-302115-r39ser2c 76 32 or or CC cord-302115-r39ser2c 76 33 a a DT cord-302115-r39ser2c 76 34 few few JJ cord-302115-r39ser2c 76 35 hours hour NNS cord-302115-r39ser2c 76 36 following follow VBG cord-302115-r39ser2c 76 37 their -PRON- PRP$ cord-302115-r39ser2c 76 38 last last JJ cord-302115-r39ser2c 76 39 official official JJ cord-302115-r39ser2c 76 40 match match NN cord-302115-r39ser2c 76 41 . . . cord-302115-r39ser2c 77 1 In in IN cord-302115-r39ser2c 77 2 COVID-19 COVID-19 NNP cord-302115-r39ser2c 77 3 , , , cord-302115-r39ser2c 77 4 the the DT cord-302115-r39ser2c 77 5 occurrence occurrence NN cord-302115-r39ser2c 77 6 of of IN cord-302115-r39ser2c 77 7 pneumonia pneumonia NN cord-302115-r39ser2c 77 8 requiring require VBG cord-302115-r39ser2c 77 9 oxygen oxygen NN cord-302115-r39ser2c 77 10 therapy therapy NN cord-302115-r39ser2c 77 11 is be VBZ cord-302115-r39ser2c 77 12 a a DT cord-302115-r39ser2c 77 13 critical critical JJ cord-302115-r39ser2c 77 14 event event NN cord-302115-r39ser2c 77 15 discriminating discriminate VBG cord-302115-r39ser2c 77 16 asymptomatic asymptomatic JJ cord-302115-r39ser2c 77 17 or or CC cord-302115-r39ser2c 77 18 mild mild JJ cord-302115-r39ser2c 77 19 cases case NNS cord-302115-r39ser2c 77 20 , , , cord-302115-r39ser2c 77 21 whose whose WP$ cord-302115-r39ser2c 77 22 infection infection NN cord-302115-r39ser2c 77 23 remains remain VBZ cord-302115-r39ser2c 77 24 mostly mostly RB cord-302115-r39ser2c 77 25 confined confine VBN cord-302115-r39ser2c 77 26 to to IN cord-302115-r39ser2c 77 27 the the DT cord-302115-r39ser2c 77 28 upper upper NNP cord-302115-r39ser2c 77 29 airways airway NNS cord-302115-r39ser2c 77 30 , , , cord-302115-r39ser2c 77 31 from from IN cord-302115-r39ser2c 77 32 those those DT cord-302115-r39ser2c 77 33 with with IN cord-302115-r39ser2c 77 34 severe severe JJ cord-302115-r39ser2c 77 35 disease disease NN cord-302115-r39ser2c 77 36 , , , cord-302115-r39ser2c 77 37 who who WP cord-302115-r39ser2c 77 38 experience experience VBP cord-302115-r39ser2c 77 39 massive massive JJ cord-302115-r39ser2c 77 40 viral viral JJ cord-302115-r39ser2c 77 41 invasion invasion NN cord-302115-r39ser2c 77 42 of of IN cord-302115-r39ser2c 77 43 their -PRON- PRP$ cord-302115-r39ser2c 77 44 lower low JJR cord-302115-r39ser2c 77 45 airways airway NNS cord-302115-r39ser2c 77 46 . . . cord-302115-r39ser2c 78 1 [ [ -LRB- cord-302115-r39ser2c 78 2 19 19 CD cord-302115-r39ser2c 78 3 ] ] -RRB- cord-302115-r39ser2c 79 1 What what WP cord-302115-r39ser2c 79 2 makes make VBZ cord-302115-r39ser2c 79 3 the the DT cord-302115-r39ser2c 79 4 difference difference NN cord-302115-r39ser2c 79 5 ? ? . cord-302115-r39ser2c 80 1 What what WP cord-302115-r39ser2c 80 2 prevents prevent VBZ cord-302115-r39ser2c 80 3 the the DT cord-302115-r39ser2c 80 4 virus virus NN cord-302115-r39ser2c 80 5 from from IN cord-302115-r39ser2c 80 6 rapidly rapidly RB cord-302115-r39ser2c 80 7 reaching reach VBG cord-302115-r39ser2c 80 8 the the DT cord-302115-r39ser2c 80 9 lungs lung NNS cord-302115-r39ser2c 80 10 and and CC cord-302115-r39ser2c 80 11 then then RB cord-302115-r39ser2c 80 12 causing cause VBG cord-302115-r39ser2c 80 13 severe severe JJ cord-302115-r39ser2c 80 14 pneumonia pneumonia NN cord-302115-r39ser2c 80 15 ? ? . cord-302115-r39ser2c 81 1 What what WP cord-302115-r39ser2c 81 2 makes make VBZ cord-302115-r39ser2c 81 3 COVID-19 covid-19 VB cord-302115-r39ser2c 81 4 pneumonia pneumonia NN cord-302115-r39ser2c 81 5 a a DT cord-302115-r39ser2c 81 6 life life NN cord-302115-r39ser2c 81 7 - - HYPH cord-302115-r39ser2c 81 8 threatening threaten VBG cord-302115-r39ser2c 81 9 disease disease NN cord-302115-r39ser2c 81 10 ? ? . cord-302115-r39ser2c 82 1 2 2 LS cord-302115-r39ser2c 82 2 ) ) -RRB- cord-302115-r39ser2c 82 3 Pneumonia Pneumonia NNP cord-302115-r39ser2c 82 4 may may MD cord-302115-r39ser2c 82 5 start start VB cord-302115-r39ser2c 82 6 before before IN cord-302115-r39ser2c 82 7 adaptive adaptive JJ cord-302115-r39ser2c 82 8 immune immune JJ cord-302115-r39ser2c 82 9 response response NN cord-302115-r39ser2c 82 10 develops develop VBZ cord-302115-r39ser2c 82 11 ; ; : cord-302115-r39ser2c 82 12 [ [ -LRB- cord-302115-r39ser2c 82 13 20 20 CD cord-302115-r39ser2c 82 14 ] ] -RRB- cord-302115-r39ser2c 82 15 3 3 CD cord-302115-r39ser2c 82 16 ) ) -RRB- cord-302115-r39ser2c 83 1 Serious serious JJ cord-302115-r39ser2c 83 2 complications complication NNS cord-302115-r39ser2c 83 3 begin begin VBP cord-302115-r39ser2c 83 4 together together RB cord-302115-r39ser2c 83 5 with with IN cord-302115-r39ser2c 83 6 the the DT cord-302115-r39ser2c 83 7 adaptive adaptive JJ cord-302115-r39ser2c 83 8 immune immune JJ cord-302115-r39ser2c 83 9 response response NN cord-302115-r39ser2c 83 10 . . . cord-302115-r39ser2c 84 1 The the DT cord-302115-r39ser2c 84 2 first first JJ cord-302115-r39ser2c 84 3 two two CD cord-302115-r39ser2c 84 4 weeks week NNS cord-302115-r39ser2c 84 5 after after IN cord-302115-r39ser2c 84 6 infection infection NN cord-302115-r39ser2c 84 7 are be VBP cord-302115-r39ser2c 84 8 crucial crucial JJ cord-302115-r39ser2c 84 9 . . . cord-302115-r39ser2c 85 1 [ [ -LRB- cord-302115-r39ser2c 85 2 18,20 18,20 CD cord-302115-r39ser2c 85 3 ] ] -RRB- cord-302115-r39ser2c 85 4 Innate innate JJ cord-302115-r39ser2c 85 5 immunity immunity NN cord-302115-r39ser2c 85 6 is be VBZ cord-302115-r39ser2c 85 7 the the DT cord-302115-r39ser2c 85 8 only only JJ cord-302115-r39ser2c 85 9 first first JJ cord-302115-r39ser2c 85 10 - - HYPH cord-302115-r39ser2c 85 11 line line NN cord-302115-r39ser2c 85 12 , , , cord-302115-r39ser2c 85 13 early early JJ cord-302115-r39ser2c 85 14 defense defense NN cord-302115-r39ser2c 85 15 against against IN cord-302115-r39ser2c 85 16 the the DT cord-302115-r39ser2c 85 17 new new JJ cord-302115-r39ser2c 85 18 SARS SARS NNP cord-302115-r39ser2c 85 19 - - HYPH cord-302115-r39ser2c 85 20 CoV-2 CoV-2 NNP cord-302115-r39ser2c 85 21 virus virus NN cord-302115-r39ser2c 85 22 . . . cord-302115-r39ser2c 86 1 Consequently consequently RB cord-302115-r39ser2c 86 2 , , , cord-302115-r39ser2c 86 3 the the DT cord-302115-r39ser2c 86 4 early early JJ cord-302115-r39ser2c 86 5 confrontation confrontation NN cord-302115-r39ser2c 86 6 between between IN cord-302115-r39ser2c 86 7 host host NN cord-302115-r39ser2c 86 8 's 's POS cord-302115-r39ser2c 86 9 innate innate JJ cord-302115-r39ser2c 86 10 immunity immunity NN cord-302115-r39ser2c 86 11 and and CC cord-302115-r39ser2c 86 12 SARS SARS NNP cord-302115-r39ser2c 86 13 - - HYPH cord-302115-r39ser2c 86 14 CoV-2 CoV-2 NNP cord-302115-r39ser2c 86 15 , , , cord-302115-r39ser2c 86 16 at at IN cord-302115-r39ser2c 86 17 exposure exposure NN cord-302115-r39ser2c 86 18 and and CC cord-302115-r39ser2c 86 19 during during IN cord-302115-r39ser2c 86 20 the the DT cord-302115-r39ser2c 86 21 following following JJ cord-302115-r39ser2c 86 22 two two CD cord-302115-r39ser2c 86 23 weeks week NNS cord-302115-r39ser2c 86 24 , , , cord-302115-r39ser2c 86 25 decides decide VBZ cord-302115-r39ser2c 86 26 the the DT cord-302115-r39ser2c 86 27 natural natural JJ cord-302115-r39ser2c 86 28 history history NN cord-302115-r39ser2c 86 29 of of IN cord-302115-r39ser2c 86 30 the the DT cord-302115-r39ser2c 86 31 disease disease NN cord-302115-r39ser2c 86 32 . . . cord-302115-r39ser2c 87 1 This this DT cord-302115-r39ser2c 87 2 confrontation confrontation NN cord-302115-r39ser2c 87 3 also also RB cord-302115-r39ser2c 87 4 decides decide VBZ cord-302115-r39ser2c 87 5 whether whether IN cord-302115-r39ser2c 87 6 the the DT cord-302115-r39ser2c 87 7 infection infection NN cord-302115-r39ser2c 87 8 will will MD cord-302115-r39ser2c 87 9 be be VB cord-302115-r39ser2c 87 10 efficiently efficiently RB cord-302115-r39ser2c 87 11 blocked block VBN cord-302115-r39ser2c 87 12 in in IN cord-302115-r39ser2c 87 13 upper upper JJ cord-302115-r39ser2c 87 14 airways airway NNS cord-302115-r39ser2c 87 15 , , , cord-302115-r39ser2c 87 16 or or CC cord-302115-r39ser2c 87 17 how how WRB cord-302115-r39ser2c 87 18 many many JJ cord-302115-r39ser2c 87 19 virus virus NN cord-302115-r39ser2c 87 20 particles particle NNS cord-302115-r39ser2c 87 21 reach reach VBP cord-302115-r39ser2c 87 22 the the DT cord-302115-r39ser2c 87 23 lungs lung NNS cord-302115-r39ser2c 87 24 , , , cord-302115-r39ser2c 87 25 and and CC cord-302115-r39ser2c 87 26 when when WRB cord-302115-r39ser2c 87 27 . . . cord-302115-r39ser2c 88 1 To to TO cord-302115-r39ser2c 88 2 understand understand VB cord-302115-r39ser2c 88 3 which which WDT cord-302115-r39ser2c 88 4 part part NN cord-302115-r39ser2c 88 5 of of IN cord-302115-r39ser2c 88 6 the the DT cord-302115-r39ser2c 88 7 innate innate JJ cord-302115-r39ser2c 88 8 immunity immunity NN cord-302115-r39ser2c 88 9 involved involve VBN cord-302115-r39ser2c 88 10 in in IN cord-302115-r39ser2c 88 11 early early JJ cord-302115-r39ser2c 88 12 protection protection NN cord-302115-r39ser2c 88 13 from from IN cord-302115-r39ser2c 88 14 SARS SARS NNP cord-302115-r39ser2c 88 15 - - HYPH cord-302115-r39ser2c 88 16 CoV-2 CoV-2 NNP cord-302115-r39ser2c 88 17 , , , cord-302115-r39ser2c 88 18 we -PRON- PRP cord-302115-r39ser2c 88 19 have have VBP cord-302115-r39ser2c 88 20 : : : cord-302115-r39ser2c 88 21 1 1 LS cord-302115-r39ser2c 88 22 ) ) -RRB- cord-302115-r39ser2c 88 23 Examined examine VBN cord-302115-r39ser2c 88 24 which which WDT cord-302115-r39ser2c 88 25 Primary Primary NNP cord-302115-r39ser2c 88 26 Immune Immune NNP cord-302115-r39ser2c 88 27 Deficiencies Deficiencies NNPS cord-302115-r39ser2c 88 28 are be VBP cord-302115-r39ser2c 88 29 associated associate VBN cord-302115-r39ser2c 88 30 with with IN cord-302115-r39ser2c 88 31 pneumonia pneumonia NN cord-302115-r39ser2c 88 32 . . . cord-302115-r39ser2c 89 1 2 2 LS cord-302115-r39ser2c 89 2 ) ) -RRB- cord-302115-r39ser2c 89 3 Examined examine VBD cord-302115-r39ser2c 89 4 the the DT cord-302115-r39ser2c 89 5 patterns pattern NNS cord-302115-r39ser2c 89 6 of of IN cord-302115-r39ser2c 89 7 risk risk NN cord-302115-r39ser2c 89 8 factors factor NNS cord-302115-r39ser2c 89 9 for for IN cord-302115-r39ser2c 89 10 COVID-19 covid-19 JJ cord-302115-r39ser2c 89 11 severity severity NN cord-302115-r39ser2c 89 12 : : : cord-302115-r39ser2c 89 13 dose dose NN cord-302115-r39ser2c 89 14 of of IN cord-302115-r39ser2c 89 15 exposure exposure NN cord-302115-r39ser2c 89 16 to to IN cord-302115-r39ser2c 89 17 SARS SARS NNP cord-302115-r39ser2c 89 18 - - HYPH cord-302115-r39ser2c 89 19 CoV-2 CoV-2 NNP cord-302115-r39ser2c 89 20 ; ; : cord-302115-r39ser2c 89 21 age age NN cord-302115-r39ser2c 89 22 , , , cord-302115-r39ser2c 89 23 gender gender NN cord-302115-r39ser2c 89 24 , , , cord-302115-r39ser2c 89 25 ABO ABO NNP cord-302115-r39ser2c 89 26 group group NN cord-302115-r39ser2c 89 27 ; ; : cord-302115-r39ser2c 89 28 3 3 LS cord-302115-r39ser2c 89 29 ) ) -RRB- cord-302115-r39ser2c 89 30 Identified identify VBD cord-302115-r39ser2c 89 31 the the DT cord-302115-r39ser2c 89 32 innate innate JJ cord-302115-r39ser2c 89 33 immunity immunity NN cord-302115-r39ser2c 89 34 components component NNS cord-302115-r39ser2c 89 35 fitting fit VBG cord-302115-r39ser2c 89 36 the the DT cord-302115-r39ser2c 89 37 same same JJ cord-302115-r39ser2c 89 38 patterns pattern NNS cord-302115-r39ser2c 89 39 of of IN cord-302115-r39ser2c 89 40 risk risk NN cord-302115-r39ser2c 89 41 factors factor NNS cord-302115-r39ser2c 89 42 ; ; : cord-302115-r39ser2c 89 43 This this DT cord-302115-r39ser2c 89 44 article article NN cord-302115-r39ser2c 89 45 is be VBZ cord-302115-r39ser2c 89 46 protected protect VBN cord-302115-r39ser2c 89 47 by by IN cord-302115-r39ser2c 89 48 copyright copyright NN cord-302115-r39ser2c 89 49 . . . cord-302115-r39ser2c 90 1 All all DT cord-302115-r39ser2c 90 2 rights right NNS cord-302115-r39ser2c 90 3 reserved reserve VBN cord-302115-r39ser2c 90 4 4 4 CD cord-302115-r39ser2c 90 5 ) ) -RRB- cord-302115-r39ser2c 90 6 Examined examine VBD cord-302115-r39ser2c 90 7 the the DT cord-302115-r39ser2c 90 8 biological biological JJ cord-302115-r39ser2c 90 9 plausibility plausibility NN cord-302115-r39ser2c 90 10 that that IN cord-302115-r39ser2c 90 11 the the DT cord-302115-r39ser2c 90 12 candidate candidate NN cord-302115-r39ser2c 90 13 molecules molecule NNS cord-302115-r39ser2c 90 14 , , , cord-302115-r39ser2c 90 15 emerging emerge VBG cord-302115-r39ser2c 90 16 from from IN cord-302115-r39ser2c 90 17 the the DT cord-302115-r39ser2c 90 18 previous previous JJ cord-302115-r39ser2c 90 19 reasoning reasoning NN cord-302115-r39ser2c 90 20 , , , cord-302115-r39ser2c 90 21 are be VBP cord-302115-r39ser2c 90 22 really really RB cord-302115-r39ser2c 90 23 essential essential JJ cord-302115-r39ser2c 90 24 in in IN cord-302115-r39ser2c 90 25 limiting limit VBG cord-302115-r39ser2c 90 26 the the DT cord-302115-r39ser2c 90 27 consequences consequence NNS cord-302115-r39ser2c 90 28 of of IN cord-302115-r39ser2c 90 29 SARS SARS NNP cord-302115-r39ser2c 90 30 - - HYPH cord-302115-r39ser2c 90 31 CoV-2 CoV-2 NNP cord-302115-r39ser2c 90 32 infection infection NN cord-302115-r39ser2c 90 33 to to IN cord-302115-r39ser2c 90 34 upper upper JJ cord-302115-r39ser2c 90 35 airways airway NNS cord-302115-r39ser2c 90 36 or or CC cord-302115-r39ser2c 90 37 to to TO cord-302115-r39ser2c 90 38 mitigate mitigate VB cord-302115-r39ser2c 90 39 the the DT cord-302115-r39ser2c 90 40 course course NN cord-302115-r39ser2c 90 41 of of IN cord-302115-r39ser2c 90 42 pneumonia pneumonia NN cord-302115-r39ser2c 90 43 . . . cord-302115-r39ser2c 91 1 These these DT cord-302115-r39ser2c 91 2 data datum NNS cord-302115-r39ser2c 91 3 suggest suggest VBP cord-302115-r39ser2c 91 4 that that IN cord-302115-r39ser2c 91 5 the the DT cord-302115-r39ser2c 91 6 lack lack NN cord-302115-r39ser2c 91 7 of of IN cord-302115-r39ser2c 91 8 natural natural JJ cord-302115-r39ser2c 91 9 IgM IgM NNP cord-302115-r39ser2c 91 10 and and CC cord-302115-r39ser2c 91 11 IgA IgA NNP cord-302115-r39ser2c 91 12 in in IN cord-302115-r39ser2c 91 13 the the DT cord-302115-r39ser2c 91 14 upper upper JJ cord-302115-r39ser2c 91 15 respiratory respiratory JJ cord-302115-r39ser2c 91 16 airways airway NNS cord-302115-r39ser2c 91 17 may may MD cord-302115-r39ser2c 91 18 have have VB cord-302115-r39ser2c 91 19 contributed contribute VBN cord-302115-r39ser2c 91 20 to to IN cord-302115-r39ser2c 91 21 the the DT cord-302115-r39ser2c 91 22 rapid rapid JJ cord-302115-r39ser2c 91 23 viral viral JJ cord-302115-r39ser2c 91 24 spread spread NN cord-302115-r39ser2c 91 25 to to IN cord-302115-r39ser2c 91 26 lungs lung NNS cord-302115-r39ser2c 91 27 , , , cord-302115-r39ser2c 91 28 causing cause VBG cord-302115-r39ser2c 91 29 pneumonia pneumonia NN cord-302115-r39ser2c 91 30 . . . cord-302115-r39ser2c 92 1 Unexpectedly unexpectedly RB cord-302115-r39ser2c 92 2 in in IN cord-302115-r39ser2c 92 3 immunodeficient immunodeficient JJ cord-302115-r39ser2c 92 4 individuals individual NNS cord-302115-r39ser2c 92 5 , , , cord-302115-r39ser2c 92 6 agammaglobulinemic agammaglobulinemic JJ cord-302115-r39ser2c 92 7 patients patient NNS cord-302115-r39ser2c 92 8 , , , cord-302115-r39ser2c 92 9 who who WP cord-302115-r39ser2c 92 10 are be VBP cord-302115-r39ser2c 92 11 unable unable JJ cord-302115-r39ser2c 92 12 to to TO cord-302115-r39ser2c 92 13 develop develop VB cord-302115-r39ser2c 92 14 specific specific JJ cord-302115-r39ser2c 92 15 SARS SARS NNP cord-302115-r39ser2c 92 16 - - HYPH cord-302115-r39ser2c 92 17 CoV-2 CoV-2 NNP cord-302115-r39ser2c 92 18 Igs Igs NNP cord-302115-r39ser2c 92 19 , , , cord-302115-r39ser2c 92 20 did do VBD cord-302115-r39ser2c 92 21 not not RB cord-302115-r39ser2c 92 22 develop develop VB cord-302115-r39ser2c 92 23 severe severe JJ cord-302115-r39ser2c 92 24 pneumonia pneumonia NN cord-302115-r39ser2c 92 25 , , , cord-302115-r39ser2c 92 26 suggesting suggest VBG cord-302115-r39ser2c 92 27 that that IN cord-302115-r39ser2c 92 28 the the DT cord-302115-r39ser2c 92 29 serious serious JJ cord-302115-r39ser2c 92 30 complications complication NNS cord-302115-r39ser2c 92 31 observed observe VBN cord-302115-r39ser2c 92 32 in in IN cord-302115-r39ser2c 92 33 other other JJ cord-302115-r39ser2c 92 34 patients patient NNS cord-302115-r39ser2c 92 35 may may MD cord-302115-r39ser2c 92 36 be be VB cord-302115-r39ser2c 92 37 related relate VBN cord-302115-r39ser2c 92 38 to to IN cord-302115-r39ser2c 92 39 the the DT cord-302115-r39ser2c 92 40 development development NN cord-302115-r39ser2c 92 41 of of IN cord-302115-r39ser2c 92 42 acquired acquire VBN cord-302115-r39ser2c 92 43 immunity immunity NN cord-302115-r39ser2c 92 44 . . . cord-302115-r39ser2c 93 1 Under under IN cord-302115-r39ser2c 93 2 the the DT cord-302115-r39ser2c 93 3 circumstances circumstance NNS cord-302115-r39ser2c 93 4 described describe VBN cord-302115-r39ser2c 93 5 above above RB cord-302115-r39ser2c 93 6 , , , cord-302115-r39ser2c 93 7 innate innate JJ cord-302115-r39ser2c 93 8 immunity immunity NN cord-302115-r39ser2c 93 9 become become VBP cord-302115-r39ser2c 93 10 an an DT cord-302115-r39ser2c 93 11 obvious obvious JJ cord-302115-r39ser2c 93 12 candidate candidate NN cord-302115-r39ser2c 93 13 to to TO cord-302115-r39ser2c 93 14 act act VB cord-302115-r39ser2c 93 15 as as RB cord-302115-r39ser2c 93 16 very very RB cord-302115-r39ser2c 93 17 first first JJ cord-302115-r39ser2c 93 18 barrier barrier NN cord-302115-r39ser2c 93 19 protecting protect VBG cord-302115-r39ser2c 93 20 of of IN cord-302115-r39ser2c 93 21 children child NNS cord-302115-r39ser2c 93 22 , , , cord-302115-r39ser2c 93 23 almost almost RB cord-302115-r39ser2c 93 24 all all DT cord-302115-r39ser2c 93 25 adults adult NNS cord-302115-r39ser2c 93 26 and and CC cord-302115-r39ser2c 93 27 most most JJS cord-302115-r39ser2c 93 28 elders elder NNS cord-302115-r39ser2c 93 29 from from IN cord-302115-r39ser2c 93 30 SARS SARS NNP cord-302115-r39ser2c 93 31 - - HYPH cord-302115-r39ser2c 93 32 CoV-2 CoV-2 NNP cord-302115-r39ser2c 93 33 . . . cord-302115-r39ser2c 94 1 Innate innate JJ cord-302115-r39ser2c 94 2 immunity immunity NN cord-302115-r39ser2c 94 3 is be VBZ cord-302115-r39ser2c 94 4 essential essential JJ cord-302115-r39ser2c 94 5 to to TO cord-302115-r39ser2c 94 6 control control VB cord-302115-r39ser2c 94 7 virus virus NN cord-302115-r39ser2c 94 8 replication replication NN cord-302115-r39ser2c 94 9 early early RB cord-302115-r39ser2c 94 10 enough enough RB cord-302115-r39ser2c 94 11 , , , cord-302115-r39ser2c 94 12 before before IN cord-302115-r39ser2c 94 13 a a DT cord-302115-r39ser2c 94 14 very very RB cord-302115-r39ser2c 94 15 effective effective JJ cord-302115-r39ser2c 94 16 adaptive adaptive JJ cord-302115-r39ser2c 94 17 immune immune JJ cord-302115-r39ser2c 94 18 response response NN cord-302115-r39ser2c 94 19 is be VBZ cord-302115-r39ser2c 94 20 generated generate VBN cord-302115-r39ser2c 94 21 . . . cord-302115-r39ser2c 95 1 [ [ -LRB- cord-302115-r39ser2c 95 2 77 77 CD cord-302115-r39ser2c 95 3 ] ] -RRB- cord-302115-r39ser2c 95 4 Accepted accepted JJ cord-302115-r39ser2c 95 5 Article Article NNP cord-302115-r39ser2c 95 6 This this DT cord-302115-r39ser2c 95 7 article article NN cord-302115-r39ser2c 95 8 is be VBZ cord-302115-r39ser2c 95 9 protected protect VBN cord-302115-r39ser2c 95 10 by by IN cord-302115-r39ser2c 95 11 copyright copyright NN cord-302115-r39ser2c 95 12 . . . cord-302115-r39ser2c 96 1 All all DT cord-302115-r39ser2c 96 2 rights right NNS cord-302115-r39ser2c 96 3 reserved reserve VBN cord-302115-r39ser2c 96 4 We -PRON- PRP cord-302115-r39ser2c 96 5 focused focus VBD cord-302115-r39ser2c 96 6 on on IN cord-302115-r39ser2c 96 7 humoral humoral JJ cord-302115-r39ser2c 96 8 components component NNS cord-302115-r39ser2c 96 9 and and CC cord-302115-r39ser2c 96 10 , , , cord-302115-r39ser2c 96 11 in in IN cord-302115-r39ser2c 96 12 particular particular JJ cord-302115-r39ser2c 96 13 on on IN cord-302115-r39ser2c 96 14 natural natural JJ cord-302115-r39ser2c 96 15 antibodies antibody NNS cord-302115-r39ser2c 96 16 and and CC cord-302115-r39ser2c 96 17 MBL MBL NNP cord-302115-r39ser2c 96 18 , , , cord-302115-r39ser2c 96 19 to to TO cord-302115-r39ser2c 96 20 ascertain ascertain VB cord-302115-r39ser2c 96 21 whether whether IN cord-302115-r39ser2c 96 22 these these DT cord-302115-r39ser2c 96 23 players player NNS cord-302115-r39ser2c 96 24 of of IN cord-302115-r39ser2c 96 25 the the DT cord-302115-r39ser2c 96 26 innate innate JJ cord-302115-r39ser2c 96 27 immunity immunity NN cord-302115-r39ser2c 96 28 fit fit VBD cord-302115-r39ser2c 96 29 all all PDT cord-302115-r39ser2c 96 30 the the DT cord-302115-r39ser2c 96 31 epidemiological epidemiological JJ cord-302115-r39ser2c 96 32 and and CC cord-302115-r39ser2c 96 33 clinical clinical JJ cord-302115-r39ser2c 96 34 pre pre NNS cord-302115-r39ser2c 96 35 - - NNS cord-302115-r39ser2c 96 36 conditions condition NNS cord-302115-r39ser2c 96 37 presented present VBN cord-302115-r39ser2c 96 38 in in IN cord-302115-r39ser2c 96 39 the the DT cord-302115-r39ser2c 96 40 last last JJ cord-302115-r39ser2c 96 41 three three CD cord-302115-r39ser2c 96 42 months month NNS cord-302115-r39ser2c 96 43 by by IN cord-302115-r39ser2c 96 44 SARS SARS NNP cord-302115-r39ser2c 96 45 - - HYPH cord-302115-r39ser2c 96 46 CoV-2 CoV-2 NNP cord-302115-r39ser2c 96 47 . . . cord-302115-r39ser2c 97 1 Finally finally RB cord-302115-r39ser2c 97 2 , , , cord-302115-r39ser2c 97 3 we -PRON- PRP cord-302115-r39ser2c 97 4 tentatively tentatively RB cord-302115-r39ser2c 97 5 describe describe VBP cord-302115-r39ser2c 97 6 mechanisms mechanism NNS cord-302115-r39ser2c 97 7 beyond beyond IN cord-302115-r39ser2c 97 8 the the DT cord-302115-r39ser2c 97 9 most most RBS cord-302115-r39ser2c 97 10 severe severe JJ cord-302115-r39ser2c 97 11 cases case NNS cord-302115-r39ser2c 97 12 of of IN cord-302115-r39ser2c 97 13 pneumonia pneumonia NN cord-302115-r39ser2c 97 14 as as IN cord-302115-r39ser2c 97 15 a a DT cord-302115-r39ser2c 97 16 possible possible JJ cord-302115-r39ser2c 97 17 consequence consequence NN cord-302115-r39ser2c 97 18 of of IN cord-302115-r39ser2c 97 19 the the DT cord-302115-r39ser2c 97 20 development development NN cord-302115-r39ser2c 97 21 of of IN cord-302115-r39ser2c 97 22 adaptive adaptive JJ cord-302115-r39ser2c 97 23 immunity immunity NN cord-302115-r39ser2c 97 24 in in IN cord-302115-r39ser2c 97 25 individuals individual NNS cord-302115-r39ser2c 97 26 with with IN cord-302115-r39ser2c 97 27 an an DT cord-302115-r39ser2c 97 28 early early JJ cord-302115-r39ser2c 97 29 high high JJ cord-302115-r39ser2c 97 30 viral viral JJ cord-302115-r39ser2c 97 31 spread spread NN cord-302115-r39ser2c 97 32 in in IN cord-302115-r39ser2c 97 33 lungs lung NNS cord-302115-r39ser2c 97 34 . . . cord-302115-r39ser2c 98 1 Anti anti JJ cord-302115-r39ser2c 98 2 - - JJ cord-302115-r39ser2c 98 3 glycan glycan JJ cord-302115-r39ser2c 98 4 natural natural JJ cord-302115-r39ser2c 98 5 antibodies antibody NNS cord-302115-r39ser2c 98 6 are be VBP cord-302115-r39ser2c 98 7 detected detect VBN cord-302115-r39ser2c 98 8 in in IN cord-302115-r39ser2c 98 9 serum serum NN cord-302115-r39ser2c 98 10 in in IN cord-302115-r39ser2c 98 11 the the DT cord-302115-r39ser2c 98 12 absence absence NN cord-302115-r39ser2c 98 13 of of IN cord-302115-r39ser2c 98 14 previous previous JJ cord-302115-r39ser2c 98 15 immunization immunization NN cord-302115-r39ser2c 98 16 , , , cord-302115-r39ser2c 98 17 are be VBP cord-302115-r39ser2c 98 18 observed observe VBN cord-302115-r39ser2c 98 19 also also RB cord-302115-r39ser2c 98 20 in in IN cord-302115-r39ser2c 98 21 gnotobiotic gnotobiotic JJ cord-302115-r39ser2c 98 22 animals animal NNS cord-302115-r39ser2c 98 23 , , , cord-302115-r39ser2c 98 24 and and CC cord-302115-r39ser2c 98 25 belong belong VBP cord-302115-r39ser2c 98 26 mostly mostly RB cord-302115-r39ser2c 98 27 to to IN cord-302115-r39ser2c 98 28 the the DT cord-302115-r39ser2c 98 29 IgM IgM NNP cord-302115-r39ser2c 98 30 isotype isotype NN cord-302115-r39ser2c 98 31 [ [ -LRB- cord-302115-r39ser2c 98 32 79 79 CD cord-302115-r39ser2c 98 33 ] ] -RRB- cord-302115-r39ser2c 98 34 but but CC cord-302115-r39ser2c 98 35 also also RB cord-302115-r39ser2c 98 36 to to IN cord-302115-r39ser2c 98 37 the the DT cord-302115-r39ser2c 98 38 IgA IgA NNP cord-302115-r39ser2c 98 39 and and CC cord-302115-r39ser2c 98 40 IgG IgG NNP cord-302115-r39ser2c 98 41 isotype isotype NN cord-302115-r39ser2c 98 42 . . . cord-302115-r39ser2c 99 1 ( ( -LRB- cord-302115-r39ser2c 99 2 B b NN cord-302115-r39ser2c 99 3 ) ) -RRB- cord-302115-r39ser2c 99 4 old old JJ cord-302115-r39ser2c 99 5 patients patient NNS cord-302115-r39ser2c 99 6 -viral -viral JJ cord-302115-r39ser2c 99 7 exposure exposure NN cord-302115-r39ser2c 99 8 is be VBZ cord-302115-r39ser2c 99 9 probably probably RB cord-302115-r39ser2c 99 10 higher high JJR cord-302115-r39ser2c 99 11 ( ( -LRB- cord-302115-r39ser2c 99 12 the the DT cord-302115-r39ser2c 99 13 source source NN cord-302115-r39ser2c 99 14 of of IN cord-302115-r39ser2c 99 15 contagion contagion NN cord-302115-r39ser2c 99 16 is be VBZ cord-302115-r39ser2c 99 17 also also RB cord-302115-r39ser2c 99 18 an an DT cord-302115-r39ser2c 99 19 old old JJ cord-302115-r39ser2c 99 20 person person NN cord-302115-r39ser2c 99 21 ) ) -RRB- cord-302115-r39ser2c 99 22 but but CC cord-302115-r39ser2c 99 23 the the DT cord-302115-r39ser2c 99 24 innate innate JJ cord-302115-r39ser2c 99 25 immunity immunity NN cord-302115-r39ser2c 99 26 is be VBZ cord-302115-r39ser2c 99 27 much much RB cord-302115-r39ser2c 99 28 weaker weak JJR cord-302115-r39ser2c 99 29 ; ; : cord-302115-r39ser2c 99 30 a a DT cord-302115-r39ser2c 99 31 high high JJ cord-302115-r39ser2c 99 32 number number NN cord-302115-r39ser2c 99 33 of of IN cord-302115-r39ser2c 99 34 viral viral JJ cord-302115-r39ser2c 99 35 particles particle NNS cord-302115-r39ser2c 99 36 can can MD cord-302115-r39ser2c 99 37 reach reach VB cord-302115-r39ser2c 99 38 the the DT cord-302115-r39ser2c 99 39 alveoli alveolus NNS cord-302115-r39ser2c 99 40 and and CC cord-302115-r39ser2c 99 41 replicate replicate VB cord-302115-r39ser2c 99 42 in in IN cord-302115-r39ser2c 99 43 type type NN cord-302115-r39ser2c 99 44 II II NNP cord-302115-r39ser2c 99 45 pneumocytes pneumocyte NNS cord-302115-r39ser2c 99 46 in in IN cord-302115-r39ser2c 99 47 coincidence coincidence NN cord-302115-r39ser2c 99 48 or or CC cord-302115-r39ser2c 99 49 even even RB cord-302115-r39ser2c 99 50 much much RB cord-302115-r39ser2c 99 51 before before IN cord-302115-r39ser2c 99 52 the the DT cord-302115-r39ser2c 99 53 This this DT cord-302115-r39ser2c 99 54 article article NN cord-302115-r39ser2c 99 55 is be VBZ cord-302115-r39ser2c 99 56 protected protect VBN cord-302115-r39ser2c 99 57 by by IN cord-302115-r39ser2c 99 58 copyright copyright NN cord-302115-r39ser2c 99 59 . . . cord-302115-r39ser2c 100 1 All all DT cord-302115-r39ser2c 100 2 rights right NNS cord-302115-r39ser2c 100 3 reserved reserve VBN cord-302115-r39ser2c 100 4 expansion expansion NN cord-302115-r39ser2c 100 5 of of IN cord-302115-r39ser2c 100 6 the the DT cord-302115-r39ser2c 100 7 specific specific JJ cord-302115-r39ser2c 100 8 immune immune JJ cord-302115-r39ser2c 100 9 response response NN cord-302115-r39ser2c 100 10 leading lead VBG cord-302115-r39ser2c 100 11 to to IN cord-302115-r39ser2c 100 12 a a DT cord-302115-r39ser2c 100 13 more more RBR cord-302115-r39ser2c 100 14 severe severe JJ cord-302115-r39ser2c 100 15 and and CC cord-302115-r39ser2c 100 16 symptomatic symptomatic JJ cord-302115-r39ser2c 100 17 pneumonia pneumonia NN cord-302115-r39ser2c 100 18 ; ; . cord-302115-r39ser2c 101 1 ( ( -LRB- cord-302115-r39ser2c 101 2 C C NNP cord-302115-r39ser2c 101 3 ) ) -RRB- cord-302115-r39ser2c 101 4 young young JJ cord-302115-r39ser2c 101 5 but but CC cord-302115-r39ser2c 101 6 highly highly RB cord-302115-r39ser2c 101 7 exposed expose VBN cord-302115-r39ser2c 101 8 patients patient NNS cord-302115-r39ser2c 102 1 -the -the NFP cord-302115-r39ser2c 102 2 exposure exposure NN cord-302115-r39ser2c 102 3 to to IN cord-302115-r39ser2c 102 4 an an DT cord-302115-r39ser2c 102 5 excessive excessive JJ cord-302115-r39ser2c 102 6 cumulative cumulative JJ cord-302115-r39ser2c 102 7 viral viral JJ cord-302115-r39ser2c 102 8 dose dose NN cord-302115-r39ser2c 102 9 ( ( -LRB- cord-302115-r39ser2c 102 10 i.e. i.e. FW cord-302115-r39ser2c 102 11 unprotected unprotected JJ cord-302115-r39ser2c 102 12 health health NN cord-302115-r39ser2c 102 13 care care NN cord-302115-r39ser2c 102 14 personnel personnel NNS cord-302115-r39ser2c 102 15 ) ) -RRB- cord-302115-r39ser2c 102 16 will will MD cord-302115-r39ser2c 102 17 overcome overcome VB cord-302115-r39ser2c 102 18 their -PRON- PRP$ cord-302115-r39ser2c 102 19 efficient efficient JJ cord-302115-r39ser2c 102 20 innate innate JJ cord-302115-r39ser2c 102 21 immunity immunity NN cord-302115-r39ser2c 102 22 . . . cord-302115-r39ser2c 103 1 Viral viral JJ cord-302115-r39ser2c 103 2 particles particle NNS cord-302115-r39ser2c 103 3 will will MD cord-302115-r39ser2c 103 4 reach reach VB cord-302115-r39ser2c 103 5 the the DT cord-302115-r39ser2c 103 6 alveoli alveolus NNS cord-302115-r39ser2c 103 7 in in IN cord-302115-r39ser2c 103 8 early early JJ cord-302115-r39ser2c 103 9 stages stage NNS cord-302115-r39ser2c 103 10 and and CC cord-302115-r39ser2c 103 11 cause cause VB cord-302115-r39ser2c 103 12 symptomatic symptomatic JJ cord-302115-r39ser2c 103 13 pneumonia pneumonia NN cord-302115-r39ser2c 103 14 ; ; : cord-302115-r39ser2c 103 15 _SP cord-302115-r39ser2c 103 16 This this DT cord-302115-r39ser2c 103 17 article article NN cord-302115-r39ser2c 103 18 is be VBZ cord-302115-r39ser2c 103 19 protected protect VBN cord-302115-r39ser2c 103 20 by by IN cord-302115-r39ser2c 103 21 copyright copyright NN cord-302115-r39ser2c 103 22 . . . cord-302115-r39ser2c 104 1 All all DT cord-302115-r39ser2c 104 2 rights right NNS cord-302115-r39ser2c 104 3 reserved reserve VBN cord-302115-r39ser2c 104 4 macrophages macrophage NNS cord-302115-r39ser2c 104 5 via via IN cord-302115-r39ser2c 104 6 Fc Fc NNP cord-302115-r39ser2c 104 7 - - HYPH cord-302115-r39ser2c 104 8 receptors receptor NNS cord-302115-r39ser2c 104 9 . . . cord-302115-r39ser2c 105 1 In in IN cord-302115-r39ser2c 105 2 addition addition NN cord-302115-r39ser2c 105 3 , , , cord-302115-r39ser2c 105 4 Ig Ig NNP cord-302115-r39ser2c 105 5 binding bind VBG cord-302115-r39ser2c 105 6 to to IN cord-302115-r39ser2c 105 7 the the DT cord-302115-r39ser2c 105 8 S S NNP cord-302115-r39ser2c 105 9 protein protein NN cord-302115-r39ser2c 105 10 of of IN cord-302115-r39ser2c 105 11 SARS SARS NNP cord-302115-r39ser2c 105 12 - - HYPH cord-302115-r39ser2c 105 13 CoV-2 CoV-2 NNP cord-302115-r39ser2c 105 14 may may MD cord-302115-r39ser2c 105 15 cause cause VB cord-302115-r39ser2c 105 16 its -PRON- PRP$ cord-302115-r39ser2c 105 17 conformational conformational JJ cord-302115-r39ser2c 105 18 changes change NNS cord-302115-r39ser2c 105 19 that that WDT cord-302115-r39ser2c 105 20 make make VBP cord-302115-r39ser2c 105 21 the the DT cord-302115-r39ser2c 105 22 binding binding NN cord-302115-r39ser2c 105 23 to to IN cord-302115-r39ser2c 105 24 the the DT cord-302115-r39ser2c 105 25 ACE-2 ACE-2 NNP cord-302115-r39ser2c 105 26 receptor receptor NN cord-302115-r39ser2c 105 27 more more RBR cord-302115-r39ser2c 105 28 effective effective JJ cord-302115-r39ser2c 105 29 for for IN cord-302115-r39ser2c 105 30 the the DT cord-302115-r39ser2c 105 31 viral viral JJ cord-302115-r39ser2c 105 32 fusion fusion NN cord-302115-r39ser2c 105 33 with with IN cord-302115-r39ser2c 105 34 the the DT cord-302115-r39ser2c 105 35 cell cell NN cord-302115-r39ser2c 105 36 membrane membrane NN cord-302115-r39ser2c 105 37 . . . cord-302115-r39ser2c 106 1 The the DT cord-302115-r39ser2c 106 2 local local JJ cord-302115-r39ser2c 106 3 high high JJ cord-302115-r39ser2c 106 4 concentration concentration NN cord-302115-r39ser2c 106 5 of of IN cord-302115-r39ser2c 106 6 cytokines cytokine NNS cord-302115-r39ser2c 106 7 and and CC cord-302115-r39ser2c 106 8 chemokines chemokine NNS cord-302115-r39ser2c 106 9 that that WDT cord-302115-r39ser2c 106 10 contribute contribute VBP cord-302115-r39ser2c 106 11 to to IN cord-302115-r39ser2c 106 12 recruitment recruitment NN cord-302115-r39ser2c 106 13 of of IN cord-302115-r39ser2c 106 14 inflammatory inflammatory JJ cord-302115-r39ser2c 106 15 cells cell NNS cord-302115-r39ser2c 106 16 and and CC cord-302115-r39ser2c 106 17 vasodilatation vasodilatation NN cord-302115-r39ser2c 106 18 , , , cord-302115-r39ser2c 106 19 permits permit VBZ cord-302115-r39ser2c 106 20 to to TO cord-302115-r39ser2c 106 21 serum serum VB cord-302115-r39ser2c 106 22 natural natural JJ cord-302115-r39ser2c 106 23 Igs Igs NNP cord-302115-r39ser2c 106 24 and and CC cord-302115-r39ser2c 106 25 MBL MBL NNP cord-302115-r39ser2c 106 26 to to TO cord-302115-r39ser2c 106 27 maintain maintain VB cord-302115-r39ser2c 106 28 a a DT cord-302115-r39ser2c 106 29 vicious vicious JJ cord-302115-r39ser2c 106 30 circle circle NN cord-302115-r39ser2c 106 31 of of IN cord-302115-r39ser2c 106 32 inflammation inflammation NN cord-302115-r39ser2c 106 33 with with IN cord-302115-r39ser2c 106 34 complement complement JJ cord-302115-r39ser2c 106 35 activation activation NN cord-302115-r39ser2c 106 36 and and CC cord-302115-r39ser2c 106 37 immunocomplexes immunocomplexes JJ cord-302115-r39ser2c 106 38 deposition deposition NN cord-302115-r39ser2c 106 39 . . . cord-302115-r39ser2c 107 1 In in IN cord-302115-r39ser2c 107 2 this this DT cord-302115-r39ser2c 107 3 light light NN cord-302115-r39ser2c 107 4 , , , cord-302115-r39ser2c 107 5 it -PRON- PRP cord-302115-r39ser2c 107 6 can can MD cord-302115-r39ser2c 107 7 not not RB cord-302115-r39ser2c 107 8 be be VB cord-302115-r39ser2c 107 9 excluded exclude VBN cord-302115-r39ser2c 107 10 that that IN cord-302115-r39ser2c 107 11 MBL MBL NNP cord-302115-r39ser2c 107 12 or or CC cord-302115-r39ser2c 107 13 IgM IgM NNP cord-302115-r39ser2c 107 14 mediated mediate VBD cord-302115-r39ser2c 107 15 immunocomplexes immunocomplexes NNP cord-302115-r39ser2c 107 16 contribute contribute VBP cord-302115-r39ser2c 107 17 to to IN cord-302115-r39ser2c 107 18 activation activation NN cord-302115-r39ser2c 107 19 of of IN cord-302115-r39ser2c 107 20 platelets platelet NNS cord-302115-r39ser2c 107 21 or or CC cord-302115-r39ser2c 107 22 tissue tissue NN cord-302115-r39ser2c 107 23 factor factor NN cord-302115-r39ser2c 107 24 leading lead VBG cord-302115-r39ser2c 107 25 to to IN cord-302115-r39ser2c 107 26 coagulation coagulation NN cord-302115-r39ser2c 107 27 and and CC cord-302115-r39ser2c 107 28 microthrombosis microthrombosis NN cord-302115-r39ser2c 107 29 that that WDT cord-302115-r39ser2c 107 30 have have VBP cord-302115-r39ser2c 107 31 been be VBN cord-302115-r39ser2c 107 32 described describe VBN cord-302115-r39ser2c 107 33 in in IN cord-302115-r39ser2c 107 34 COVID-19 COVID-19 NNP cord-302115-r39ser2c 107 35 patients patient NNS cord-302115-r39ser2c 107 36 with with IN cord-302115-r39ser2c 107 37 acute acute JJ cord-302115-r39ser2c 107 38 respiratory respiratory JJ cord-302115-r39ser2c 107 39 failure failure NN cord-302115-r39ser2c 107 40 . . . cord-302115-r39ser2c 108 1 In in IN cord-302115-r39ser2c 108 2 this this DT cord-302115-r39ser2c 108 3 phase phase NN cord-302115-r39ser2c 108 4 of of IN cord-302115-r39ser2c 108 5 the the DT cord-302115-r39ser2c 108 6 disease disease NN cord-302115-r39ser2c 108 7 , , , cord-302115-r39ser2c 108 8 natural natural JJ cord-302115-r39ser2c 108 9 IgM IgM NNP cord-302115-r39ser2c 108 10 and and CC cord-302115-r39ser2c 108 11 MBL MBL NNP cord-302115-r39ser2c 108 12 that that WDT cord-302115-r39ser2c 108 13 circulate circulate VBP cord-302115-r39ser2c 108 14 in in IN cord-302115-r39ser2c 108 15 serum serum NN cord-302115-r39ser2c 108 16 may may MD cord-302115-r39ser2c 108 17 have have VB cord-302115-r39ser2c 108 18 no no DT cord-302115-r39ser2c 108 19 protective protective JJ cord-302115-r39ser2c 108 20 role role NN cord-302115-r39ser2c 108 21 , , , cord-302115-r39ser2c 108 22 but but CC cord-302115-r39ser2c 108 23 , , , cord-302115-r39ser2c 108 24 rather rather RB cord-302115-r39ser2c 108 25 may may MD cord-302115-r39ser2c 108 26 contribute contribute VB cord-302115-r39ser2c 108 27 to to IN cord-302115-r39ser2c 108 28 tissue tissue NN cord-302115-r39ser2c 108 29 damage damage NN cord-302115-r39ser2c 108 30 . . . cord-302115-r39ser2c 109 1 Moreover moreover RB cord-302115-r39ser2c 109 2 , , , cord-302115-r39ser2c 109 3 during during IN cord-302115-r39ser2c 109 4 this this DT cord-302115-r39ser2c 109 5 second second JJ cord-302115-r39ser2c 109 6 phase phase NN cord-302115-r39ser2c 109 7 of of IN cord-302115-r39ser2c 109 8 the the DT cord-302115-r39ser2c 109 9 disease disease NN cord-302115-r39ser2c 109 10 , , , cord-302115-r39ser2c 109 11 the the DT cord-302115-r39ser2c 109 12 adaptive adaptive JJ cord-302115-r39ser2c 109 13 response response NN cord-302115-r39ser2c 109 14 is be VBZ cord-302115-r39ser2c 109 15 also also RB cord-302115-r39ser2c 109 16 progressively progressively RB cord-302115-r39ser2c 109 17 on on IN cord-302115-r39ser2c 109 18 the the DT cord-302115-r39ser2c 109 19 increase increase NN cord-302115-r39ser2c 109 20 . . . cord-302115-r39ser2c 110 1 This this DT cord-302115-r39ser2c 110 2 may may MD cord-302115-r39ser2c 110 3 be be VB cord-302115-r39ser2c 110 4 one one CD cord-302115-r39ser2c 110 5 side side NN cord-302115-r39ser2c 110 6 protective protective JJ cord-302115-r39ser2c 110 7 against against IN cord-302115-r39ser2c 110 8 further further JJ cord-302115-r39ser2c 110 9 virus virus NN cord-302115-r39ser2c 110 10 spread spread VBN cord-302115-r39ser2c 110 11 in in IN cord-302115-r39ser2c 110 12 the the DT cord-302115-r39ser2c 110 13 lungs lung NNS cord-302115-r39ser2c 110 14 , , , cord-302115-r39ser2c 110 15 but but CC cord-302115-r39ser2c 110 16 may may MD cord-302115-r39ser2c 110 17 also also RB cord-302115-r39ser2c 110 18 reinforce reinforce VB cord-302115-r39ser2c 110 19 the the DT cord-302115-r39ser2c 110 20 immunological immunological JJ cord-302115-r39ser2c 110 21 and and CC cord-302115-r39ser2c 110 22 coagulation coagulation NN cord-302115-r39ser2c 110 23 cascades cascade NNS cord-302115-r39ser2c 110 24 provoking provoke VBG cord-302115-r39ser2c 110 25 complications complication NNS cord-302115-r39ser2c 110 26 . . . cord-302115-r39ser2c 111 1 MBL MBL NNP cord-302115-r39ser2c 111 2 binds bind VBZ cord-302115-r39ser2c 111 3 to to IN cord-302115-r39ser2c 111 4 polymeric polymeric JJ cord-302115-r39ser2c 111 5 IgA IgA NNP cord-302115-r39ser2c 111 6 and and CC cord-302115-r39ser2c 111 7 initiates initiate VBZ cord-302115-r39ser2c 111 8 complement complement JJ cord-302115-r39ser2c 111 9 cascade cascade NN cord-302115-r39ser2c 111 10 , , , cord-302115-r39ser2c 111 11 a a DT cord-302115-r39ser2c 111 12 defense defense NN cord-302115-r39ser2c 111 13 against against IN cord-302115-r39ser2c 111 14 invading invade VBG cord-302115-r39ser2c 111 15 pathogens pathogen NNS cord-302115-r39ser2c 111 16 in in IN cord-302115-r39ser2c 111 17 mucosal mucosal JJ cord-302115-r39ser2c 111 18 immunity immunity NN cord-302115-r39ser2c 111 19 . . . cord-302115-r39ser2c 112 1 Polymeric polymeric JJ cord-302115-r39ser2c 112 2 IgA IgA NNP cord-302115-r39ser2c 112 3 also also RB cord-302115-r39ser2c 112 4 has have VBZ cord-302115-r39ser2c 112 5 a a DT cord-302115-r39ser2c 112 6 role role NN cord-302115-r39ser2c 112 7 in in IN cord-302115-r39ser2c 112 8 activating activate VBG cord-302115-r39ser2c 112 9 lectin lectin NN cord-302115-r39ser2c 112 10 - - HYPH cord-302115-r39ser2c 112 11 mediated mediate VBN cord-302115-r39ser2c 112 12 complement complement NN cord-302115-r39ser2c 112 13 signaling signaling NN cord-302115-r39ser2c 112 14 . . . cord-302115-r39ser2c 113 1 The the DT cord-302115-r39ser2c 113 2 complement complement NN cord-302115-r39ser2c 113 3 cascade cascade NN cord-302115-r39ser2c 113 4 links link VBZ cord-302115-r39ser2c 113 5 the the DT cord-302115-r39ser2c 113 6 innate innate JJ cord-302115-r39ser2c 113 7 and and CC cord-302115-r39ser2c 113 8 the the DT cord-302115-r39ser2c 113 9 adaptive adaptive JJ cord-302115-r39ser2c 113 10 immune immune JJ cord-302115-r39ser2c 113 11 system system NN cord-302115-r39ser2c 113 12 , , , cord-302115-r39ser2c 113 13 protecting protect VBG cord-302115-r39ser2c 113 14 against against IN cord-302115-r39ser2c 113 15 invading invade VBG cord-302115-r39ser2c 113 16 pathogens pathogen NNS cord-302115-r39ser2c 113 17 during during IN cord-302115-r39ser2c 113 18 the the DT cord-302115-r39ser2c 113 19 first first JJ cord-302115-r39ser2c 113 20 phase phase NN cord-302115-r39ser2c 113 21 of of IN cord-302115-r39ser2c 113 22 the the DT cord-302115-r39ser2c 113 23 diseases disease NNS cord-302115-r39ser2c 113 24 . . . cord-302115-r39ser2c 114 1 In in IN cord-302115-r39ser2c 114 2 this this DT cord-302115-r39ser2c 114 3 sense sense NN cord-302115-r39ser2c 114 4 , , , cord-302115-r39ser2c 114 5 Ab ab NN cord-302115-r39ser2c 114 6 - - HYPH cord-302115-r39ser2c 114 7 mediated mediate VBN cord-302115-r39ser2c 114 8 complement complement NN cord-302115-r39ser2c 114 9 activation activation NN cord-302115-r39ser2c 114 10 flows flow NNS cord-302115-r39ser2c 114 11 in in IN cord-302115-r39ser2c 114 12 parallel parallel NN cord-302115-r39ser2c 114 13 between between IN cord-302115-r39ser2c 114 14 MBL MBL NNP cord-302115-r39ser2c 114 15 and and CC cord-302115-r39ser2c 114 16 C1q C1q NNP cord-302115-r39ser2c 114 17 . . . cord-302115-r39ser2c 115 1 Additionally additionally RB cord-302115-r39ser2c 115 2 , , , cord-302115-r39ser2c 115 3 it -PRON- PRP cord-302115-r39ser2c 115 4 can can MD cord-302115-r39ser2c 115 5 boost boost VB cord-302115-r39ser2c 115 6 proinflammatory proinflammatory JJ cord-302115-r39ser2c 115 7 effects effect NNS cord-302115-r39ser2c 115 8 of of IN cord-302115-r39ser2c 115 9 IgA IgA NNP cord-302115-r39ser2c 115 10 deposition deposition NN cord-302115-r39ser2c 115 11 with with IN cord-302115-r39ser2c 115 12 the the DT cord-302115-r39ser2c 115 13 same same JJ cord-302115-r39ser2c 115 14 mechanism mechanism NN cord-302115-r39ser2c 115 15 that that WDT cord-302115-r39ser2c 115 16 is be VBZ cord-302115-r39ser2c 115 17 supposed suppose VBN cord-302115-r39ser2c 115 18 to to TO cord-302115-r39ser2c 115 19 occur occur VB cord-302115-r39ser2c 115 20 in in IN cord-302115-r39ser2c 115 21 the the DT cord-302115-r39ser2c 115 22 glomerulus glomerulus NN cord-302115-r39ser2c 115 23 , , , cord-302115-r39ser2c 115 24 and and CC cord-302115-r39ser2c 115 25 results result NNS cord-302115-r39ser2c 115 26 in in IN cord-302115-r39ser2c 115 27 renal renal JJ cord-302115-r39ser2c 115 28 injury injury NN cord-302115-r39ser2c 115 29 . . . cord-302115-r39ser2c 116 1 This this DT cord-302115-r39ser2c 116 2 article article NN cord-302115-r39ser2c 116 3 is be VBZ cord-302115-r39ser2c 116 4 protected protect VBN cord-302115-r39ser2c 116 5 by by IN cord-302115-r39ser2c 116 6 copyright copyright NN cord-302115-r39ser2c 116 7 . . . cord-302115-r39ser2c 117 1 All all DT cord-302115-r39ser2c 117 2 rights right NNS cord-302115-r39ser2c 117 3 reserved reserve VBN cord-302115-r39ser2c 117 4 Evidence evidence NN cord-302115-r39ser2c 117 5 - - HYPH cord-302115-r39ser2c 117 6 based base VBN cord-302115-r39ser2c 117 7 medicine medicine NN cord-302115-r39ser2c 117 8 should should MD cord-302115-r39ser2c 117 9 also also RB cord-302115-r39ser2c 117 10 apply apply VB cord-302115-r39ser2c 117 11 for for IN cord-302115-r39ser2c 117 12 Covid-19 covid-19 NN cord-302115-r39ser2c 117 13 patients patient NNS cord-302115-r39ser2c 117 14 , , , cord-302115-r39ser2c 117 15 so so IN cord-302115-r39ser2c 117 16 that that IN cord-302115-r39ser2c 117 17 " " `` cord-302115-r39ser2c 117 18 new new JJ cord-302115-r39ser2c 117 19 " " '' cord-302115-r39ser2c 117 20 or or CC cord-302115-r39ser2c 117 21 off off IN cord-302115-r39ser2c 117 22 - - HYPH cord-302115-r39ser2c 117 23 label label NN cord-302115-r39ser2c 117 24 drugs drug NNS cord-302115-r39ser2c 117 25 or or CC cord-302115-r39ser2c 117 26 treatment treatment NN cord-302115-r39ser2c 117 27 regimens regimen NNS cord-302115-r39ser2c 117 28 should should MD cord-302115-r39ser2c 117 29 only only RB cord-302115-r39ser2c 117 30 be be VB cord-302115-r39ser2c 117 31 given give VBN cord-302115-r39ser2c 117 32 in in IN cord-302115-r39ser2c 117 33 a a DT cord-302115-r39ser2c 117 34 clinical clinical JJ cord-302115-r39ser2c 117 35 study study NN cord-302115-r39ser2c 117 36 context context NN cord-302115-r39ser2c 117 37 , , , cord-302115-r39ser2c 117 38 following follow VBG cord-302115-r39ser2c 117 39 approval approval NN cord-302115-r39ser2c 117 40 by by IN cord-302115-r39ser2c 117 41 relevant relevant JJ cord-302115-r39ser2c 117 42 national national JJ cord-302115-r39ser2c 117 43 or or CC cord-302115-r39ser2c 117 44 international international JJ cord-302115-r39ser2c 117 45 agencies agency NNS cord-302115-r39ser2c 117 46 . . . cord-302115-r39ser2c 118 1 However however RB cord-302115-r39ser2c 118 2 , , , cord-302115-r39ser2c 118 3 we -PRON- PRP cord-302115-r39ser2c 118 4 believe believe VBP cord-302115-r39ser2c 118 5 that that IN cord-302115-r39ser2c 118 6 these these DT cord-302115-r39ser2c 118 7 points point NNS cord-302115-r39ser2c 118 8 are be VBP cord-302115-r39ser2c 118 9 first first JJ cord-302115-r39ser2c 118 10 priorities priority NNS cord-302115-r39ser2c 118 11 for for IN cord-302115-r39ser2c 118 12 intensively intensively RB cord-302115-r39ser2c 118 13 and and CC cord-302115-r39ser2c 118 14 focused focus VBD cord-302115-r39ser2c 118 15 clinically clinically RB cord-302115-r39ser2c 118 16 oriented orient VBN cord-302115-r39ser2c 118 17 research research NN cord-302115-r39ser2c 118 18 . . . cord-302115-r39ser2c 118 19 _SP cord-302115-r39ser2c 119 1 microarras microarras NNP cord-302115-r39ser2c 119 2 and and CC cord-302115-r39ser2c 119 3 other other JJ cord-302115-r39ser2c 119 4 tests test NNS cord-302115-r39ser2c 119 5 aimed aim VBN cord-302115-r39ser2c 119 6 at at IN cord-302115-r39ser2c 119 7 measuring measure VBG cord-302115-r39ser2c 119 8 natural natural JJ cord-302115-r39ser2c 119 9 antibodies antibody NNS cord-302115-r39ser2c 119 10 , , , cord-302115-r39ser2c 119 11 that that WDT cord-302115-r39ser2c 119 12 might may MD cord-302115-r39ser2c 119 13 be be VB cord-302115-r39ser2c 119 14 protective protective JJ cord-302115-r39ser2c 119 15 against against IN cord-302115-r39ser2c 119 16 SARS SARS NNP cord-302115-r39ser2c 119 17 - - HYPH cord-302115-r39ser2c 119 18 CoV-2 CoV-2 NNP cord-302115-r39ser2c 119 19 and and CC cord-302115-r39ser2c 119 20 other other JJ cord-302115-r39ser2c 119 21 viruses virus NNS cord-302115-r39ser2c 119 22 , , , cord-302115-r39ser2c 119 23 should should MD cord-302115-r39ser2c 119 24 be be VB cord-302115-r39ser2c 119 25 developed develop VBN cord-302115-r39ser2c 119 26 . . . cord-302115-r39ser2c 120 1 Individuals individual NNS cord-302115-r39ser2c 120 2 with with IN cord-302115-r39ser2c 120 3 low low JJ cord-302115-r39ser2c 120 4 natural natural JJ cord-302115-r39ser2c 120 5 antibody antibody NN cord-302115-r39ser2c 120 6 and and CC cord-302115-r39ser2c 120 7 MBL MBL NNP cord-302115-r39ser2c 120 8 levels level NNS cord-302115-r39ser2c 120 9 should should MD cord-302115-r39ser2c 120 10 be be VB cord-302115-r39ser2c 120 11 identified identify VBN cord-302115-r39ser2c 120 12 and and CC cord-302115-r39ser2c 120 13 specifically specifically RB cord-302115-r39ser2c 120 14 protected protect VBN cord-302115-r39ser2c 120 15 . . . cord-302115-r39ser2c 121 1 Moreover moreover RB cord-302115-r39ser2c 121 2 , , , cord-302115-r39ser2c 121 3 governments government NNS cord-302115-r39ser2c 121 4 promoting promote VBG cord-302115-r39ser2c 121 5 herd herd NN cord-302115-r39ser2c 121 6 immunity immunity NN cord-302115-r39ser2c 121 7 must must MD cord-302115-r39ser2c 121 8 protect protect VB cord-302115-r39ser2c 121 9 individuals individual NNS cord-302115-r39ser2c 121 10 , , , cord-302115-r39ser2c 121 11 even even RB cord-302115-r39ser2c 121 12 if if IN cord-302115-r39ser2c 121 13 young young JJ cord-302115-r39ser2c 121 14 , , , cord-302115-r39ser2c 121 15 who who WP cord-302115-r39ser2c 121 16 may may MD cord-302115-r39ser2c 121 17 have have VB cord-302115-r39ser2c 121 18 low low JJ cord-302115-r39ser2c 121 19 levels level NNS cord-302115-r39ser2c 121 20 of of IN cord-302115-r39ser2c 121 21 natural natural JJ cord-302115-r39ser2c 121 22 antibodies antibody NNS cord-302115-r39ser2c 121 23 . . . cord-302115-r39ser2c 122 1 These these DT cord-302115-r39ser2c 122 2 individuals individual NNS cord-302115-r39ser2c 122 3 should should MD cord-302115-r39ser2c 122 4 be be VB cord-302115-r39ser2c 122 5 not not RB cord-302115-r39ser2c 122 6 exposed expose VBN cord-302115-r39ser2c 122 7 to to IN cord-302115-r39ser2c 122 8 the the DT cord-302115-r39ser2c 122 9 virus virus NN cord-302115-r39ser2c 122 10 , , , cord-302115-r39ser2c 122 11 especially especially RB cord-302115-r39ser2c 122 12 if if IN cord-302115-r39ser2c 122 13 shed shed VBN cord-302115-r39ser2c 122 14 at at IN cord-302115-r39ser2c 122 15 high high JJ cord-302115-r39ser2c 122 16 doses dose NNS cord-302115-r39ser2c 122 17 . . . cord-302115-r39ser2c 123 1 including include VBG cord-302115-r39ser2c 123 2 strenuous strenuous JJ cord-302115-r39ser2c 123 3 sport sport NN cord-302115-r39ser2c 123 4 activities activity NNS cord-302115-r39ser2c 123 5 requiring require VBG cord-302115-r39ser2c 123 6 high high JJ cord-302115-r39ser2c 123 7 respiratory respiratory JJ cord-302115-r39ser2c 123 8 volumes volume NNS cord-302115-r39ser2c 123 9 and and CC cord-302115-r39ser2c 123 10 flows flow NNS cord-302115-r39ser2c 123 11 , , , cord-302115-r39ser2c 123 12 should should MD cord-302115-r39ser2c 123 13 be be VB cord-302115-r39ser2c 123 14 avoided avoid VBN cord-302115-r39ser2c 123 15 during during IN cord-302115-r39ser2c 123 16 the the DT cord-302115-r39ser2c 123 17 early early JJ cord-302115-r39ser2c 123 18 stage stage NN cord-302115-r39ser2c 123 19 of of IN cord-302115-r39ser2c 123 20 infection infection NN cord-302115-r39ser2c 123 21 . . . cord-302115-r39ser2c 124 1 when when WRB cord-302115-r39ser2c 124 2 the the DT cord-302115-r39ser2c 124 3 adaptive adaptive JJ cord-302115-r39ser2c 124 4 immune immune JJ cord-302115-r39ser2c 124 5 response response NN cord-302115-r39ser2c 124 6 is be VBZ cord-302115-r39ser2c 124 7 This this DT cord-302115-r39ser2c 124 8 article article NN cord-302115-r39ser2c 124 9 is be VBZ cord-302115-r39ser2c 124 10 protected protect VBN cord-302115-r39ser2c 124 11 by by IN cord-302115-r39ser2c 124 12 copyright copyright NN cord-302115-r39ser2c 124 13 . . . cord-302115-r39ser2c 125 1 All all DT cord-302115-r39ser2c 125 2 rights right NNS cord-302115-r39ser2c 125 3 reserved reserve VBN cord-302115-r39ser2c 125 4 still still RB cord-302115-r39ser2c 125 5 not not RB cord-302115-r39ser2c 125 6 initiated initiate VBN cord-302115-r39ser2c 125 7 . . . cord-302115-r39ser2c 126 1 Particular particular JJ cord-302115-r39ser2c 126 2 precautions precaution NNS cord-302115-r39ser2c 126 3 should should MD cord-302115-r39ser2c 126 4 be be VB cord-302115-r39ser2c 126 5 given give VBN cord-302115-r39ser2c 126 6 to to IN cord-302115-r39ser2c 126 7 athletes athlete NNS cord-302115-r39ser2c 126 8 performing perform VBG cord-302115-r39ser2c 126 9 fatiguing fatiguing JJ cord-302115-r39ser2c 126 10 sports sport NNS cord-302115-r39ser2c 126 11 , , , cord-302115-r39ser2c 126 12 since since IN cord-302115-r39ser2c 126 13 a a DT cord-302115-r39ser2c 126 14 portion portion NN cord-302115-r39ser2c 126 15 of of IN cord-302115-r39ser2c 126 16 sub sub JJ cord-302115-r39ser2c 126 17 - - HYPH cord-302115-r39ser2c 126 18 micrometer micrometer NN cord-302115-r39ser2c 126 19 - - HYPH cord-302115-r39ser2c 126 20 size size NN cord-302115-r39ser2c 126 21 , , , cord-302115-r39ser2c 126 22 aerosolized aerosolize VBN cord-302115-r39ser2c 126 23 particles particle NNS cord-302115-r39ser2c 126 24 , , , cord-302115-r39ser2c 126 25 are be VBP cord-302115-r39ser2c 126 26 expired expire VBN cord-302115-r39ser2c 126 27 by by IN cord-302115-r39ser2c 126 28 the the DT cord-302115-r39ser2c 126 29 runner runner NN cord-302115-r39ser2c 126 30 or or CC cord-302115-r39ser2c 126 31 eliminated eliminate VBN cord-302115-r39ser2c 126 32 by by IN cord-302115-r39ser2c 126 33 cough cough NN cord-302115-r39ser2c 126 34 or or CC cord-302115-r39ser2c 126 35 nasal nasal NN cord-302115-r39ser2c 126 36 secretions secretion NNS cord-302115-r39ser2c 126 37 and and CC cord-302115-r39ser2c 126 38 may may MD cord-302115-r39ser2c 126 39 contain contain VB cord-302115-r39ser2c 126 40 viruses virus NNS cord-302115-r39ser2c 126 41 if if IN cord-302115-r39ser2c 126 42 the the DT cord-302115-r39ser2c 126 43 athlete athlete NN cord-302115-r39ser2c 126 44 is be VBZ cord-302115-r39ser2c 126 45 an an DT cord-302115-r39ser2c 126 46 asymptomatic asymptomatic JJ cord-302115-r39ser2c 126 47 but but CC cord-302115-r39ser2c 126 48 SARS SARS NNP cord-302115-r39ser2c 126 49 - - HYPH cord-302115-r39ser2c 126 50 CoV2 CoV2 NNP cord-302115-r39ser2c 126 51 infected infect VBN cord-302115-r39ser2c 126 52 individual individual NN cord-302115-r39ser2c 126 53 . . . cord-302115-r39ser2c 127 1 These these DT cord-302115-r39ser2c 127 2 droplets droplet NNS cord-302115-r39ser2c 127 3 or or CC cord-302115-r39ser2c 127 4 aerosol aerosol NN cord-302115-r39ser2c 127 5 might may MD cord-302115-r39ser2c 127 6 be be VB cord-302115-r39ser2c 127 7 re re VBN cord-302115-r39ser2c 127 8 - - VBN cord-302115-r39ser2c 127 9 inhaled inhale VBN cord-302115-r39ser2c 127 10 and and CC cord-302115-r39ser2c 127 11 facilitate facilitate VB cord-302115-r39ser2c 127 12 the the DT cord-302115-r39ser2c 127 13 spread spread NN cord-302115-r39ser2c 127 14 of of IN cord-302115-r39ser2c 127 15 the the DT cord-302115-r39ser2c 127 16 virus virus NN cord-302115-r39ser2c 127 17 from from IN cord-302115-r39ser2c 127 18 the the DT cord-302115-r39ser2c 127 19 upper upper NN cord-302115-r39ser2c 127 20 to to IN cord-302115-r39ser2c 127 21 the the DT cord-302115-r39ser2c 127 22 lower low JJR cord-302115-r39ser2c 127 23 airways airway NNS cord-302115-r39ser2c 127 24 . . . cord-302115-r39ser2c 127 25 _SP cord-302115-r39ser2c 128 1 This this DT cord-302115-r39ser2c 128 2 article article NN cord-302115-r39ser2c 128 3 is be VBZ cord-302115-r39ser2c 128 4 protected protect VBN cord-302115-r39ser2c 128 5 by by IN cord-302115-r39ser2c 128 6 copyright copyright NN cord-302115-r39ser2c 128 7 . . . cord-302115-r39ser2c 129 1 All all DT cord-302115-r39ser2c 129 2 rights right NNS cord-302115-r39ser2c 129 3 reserved reserve VBN cord-302115-r39ser2c 129 4 moieties moiety NNS cord-302115-r39ser2c 129 5 flanking flank VBG cord-302115-r39ser2c 129 6 SARS SARS NNP cord-302115-r39ser2c 129 7 - - HYPH cord-302115-r39ser2c 129 8 CoV-2 CoV-2 NNP cord-302115-r39ser2c 129 9 S1-RBS S1-RBS NNP cord-302115-r39ser2c 129 10 may may MD cord-302115-r39ser2c 129 11 be be VB cord-302115-r39ser2c 129 12 useful useful JJ cord-302115-r39ser2c 129 13 , , , cord-302115-r39ser2c 129 14 among among IN cord-302115-r39ser2c 129 15 elders elder NNS cord-302115-r39ser2c 129 16 , , , cord-302115-r39ser2c 129 17 to to TO cord-302115-r39ser2c 129 18 identify identify VB cord-302115-r39ser2c 129 19 those those DT cord-302115-r39ser2c 129 20 at at IN cord-302115-r39ser2c 129 21 higher high JJR cord-302115-r39ser2c 129 22 risk risk NN cord-302115-r39ser2c 129 23 of of IN cord-302115-r39ser2c 129 24 severe severe JJ cord-302115-r39ser2c 129 25 disease disease NN cord-302115-r39ser2c 129 26 . . . cord-302115-r39ser2c 130 1 Glycan glycan JJ cord-302115-r39ser2c 130 2 microarrays microarray NNS cord-302115-r39ser2c 130 3 will will MD cord-302115-r39ser2c 130 4 be be VB cord-302115-r39ser2c 130 5 instrumental instrumental JJ cord-302115-r39ser2c 130 6 for for IN cord-302115-r39ser2c 130 7 this this DT cord-302115-r39ser2c 130 8 target target NN cord-302115-r39ser2c 130 9 . . . cord-302115-r39ser2c 131 1 paucisymptomatic paucisymptomatic JJ cord-302115-r39ser2c 131 2 individuals individual NNS cord-302115-r39ser2c 131 3 could could MD cord-302115-r39ser2c 131 4 be be VB cord-302115-r39ser2c 131 5 pursued pursue VBN cord-302115-r39ser2c 131 6 by by IN cord-302115-r39ser2c 131 7 measuring measure VBG cord-302115-r39ser2c 131 8 SARS SARS NNP cord-302115-r39ser2c 131 9 - - HYPH cord-302115-r39ser2c 131 10 CoV-2 CoV-2 NNP cord-302115-r39ser2c 131 11 specific specific JJ cord-302115-r39ser2c 131 12 serum serum NN cord-302115-r39ser2c 131 13 IgG igg NN cord-302115-r39ser2c 131 14 and and CC cord-302115-r39ser2c 131 15 IgA IgA NNP cord-302115-r39ser2c 131 16 that that WDT cord-302115-r39ser2c 131 17 are be VBP cord-302115-r39ser2c 131 18 expected expect VBN cord-302115-r39ser2c 131 19 to to TO cord-302115-r39ser2c 131 20 persist persist VB cord-302115-r39ser2c 131 21 as as IN cord-302115-r39ser2c 131 22 a a DT cord-302115-r39ser2c 131 23 memory memory NN cord-302115-r39ser2c 131 24 response response NN cord-302115-r39ser2c 131 25 to to IN cord-302115-r39ser2c 131 26 infection infection NN cord-302115-r39ser2c 131 27 . . . cord-302115-r39ser2c 132 1 Appropriate appropriate JJ cord-302115-r39ser2c 132 2 and and CC cord-302115-r39ser2c 132 3 high high JJ cord-302115-r39ser2c 132 4 performing perform VBG cord-302115-r39ser2c 132 5 validated validate VBN cord-302115-r39ser2c 132 6 tests test NNS cord-302115-r39ser2c 132 7 should should MD cord-302115-r39ser2c 132 8 be be VB cord-302115-r39ser2c 132 9 used use VBN cord-302115-r39ser2c 132 10 to to TO cord-302115-r39ser2c 132 11 retrospectively retrospectively RB cord-302115-r39ser2c 132 12 evaluate evaluate VB cord-302115-r39ser2c 132 13 the the DT cord-302115-r39ser2c 132 14 seroconversion seroconversion NN cord-302115-r39ser2c 132 15 status status NN cord-302115-r39ser2c 132 16 to to TO cord-302115-r39ser2c 132 17 estimate estimate VB cord-302115-r39ser2c 132 18 the the DT cord-302115-r39ser2c 132 19 herd herd NN cord-302115-r39ser2c 132 20 immunity immunity NN cord-302115-r39ser2c 132 21 of of IN cord-302115-r39ser2c 132 22 a a DT cord-302115-r39ser2c 132 23 given give VBN cord-302115-r39ser2c 132 24 population population NN cord-302115-r39ser2c 132 25 . . . cord-302115-r39ser2c 133 1 Immunization immunization NN cord-302115-r39ser2c 133 2 strategy strategy NN cord-302115-r39ser2c 133 3 : : : cord-302115-r39ser2c 133 4 innate innate JJ cord-302115-r39ser2c 133 5 and and CC cord-302115-r39ser2c 133 6 adaptive adaptive JJ cord-302115-r39ser2c 133 7 immunity immunity NN cord-302115-r39ser2c 133 8 10.5.1 10.5.1 CD cord-302115-r39ser2c 134 1 While while IN cord-302115-r39ser2c 134 2 effective effective JJ cord-302115-r39ser2c 134 3 vaccines vaccine NNS cord-302115-r39ser2c 134 4 are be VBP cord-302115-r39ser2c 134 5 being be VBG cord-302115-r39ser2c 134 6 developed develop VBN cord-302115-r39ser2c 134 7 , , , cord-302115-r39ser2c 134 8 produced produce VBN cord-302115-r39ser2c 134 9 , , , cord-302115-r39ser2c 134 10 tested test VBN cord-302115-r39ser2c 134 11 , , , cord-302115-r39ser2c 134 12 and and CC cord-302115-r39ser2c 134 13 validated validate VBD cord-302115-r39ser2c 134 14 , , , cord-302115-r39ser2c 134 15 a a DT cord-302115-r39ser2c 134 16 strategy strategy NN cord-302115-r39ser2c 134 17 to to TO cord-302115-r39ser2c 134 18 stimulate stimulate VB cord-302115-r39ser2c 134 19 innate innate JJ cord-302115-r39ser2c 134 20 immunity immunity NN cord-302115-r39ser2c 134 21 and and CC cord-302115-r39ser2c 134 22 natural natural JJ cord-302115-r39ser2c 134 23 IgM IgM NNP cord-302115-r39ser2c 134 24 antibody antibody NNP cord-302115-r39ser2c 134 25 production production NN cord-302115-r39ser2c 134 26 in in IN cord-302115-r39ser2c 134 27 particular particular JJ cord-302115-r39ser2c 134 28 , , , cord-302115-r39ser2c 134 29 would would MD cord-302115-r39ser2c 134 30 empower empower VB cord-302115-r39ser2c 134 31 the the DT cord-302115-r39ser2c 134 32 defences defence NNS cord-302115-r39ser2c 134 33 of of IN cord-302115-r39ser2c 134 34 at at IN cord-302115-r39ser2c 134 35 - - HYPH cord-302115-r39ser2c 134 36 risk risk NN cord-302115-r39ser2c 134 37 elderly elderly JJ cord-302115-r39ser2c 134 38 population population NN cord-302115-r39ser2c 134 39 . . . cord-302115-r39ser2c 135 1 These these DT cord-302115-r39ser2c 135 2 measures measure NNS cord-302115-r39ser2c 135 3 may may MD cord-302115-r39ser2c 135 4 include include VB cord-302115-r39ser2c 135 5 influenza influenza NN cord-302115-r39ser2c 135 6 , , , cord-302115-r39ser2c 135 7 pneumococcal pneumococcal JJ cord-302115-r39ser2c 135 8 , , , cord-302115-r39ser2c 135 9 BCG BCG NNP cord-302115-r39ser2c 135 10 and and CC cord-302115-r39ser2c 135 11 other other JJ cord-302115-r39ser2c 135 12 immunizations immunization NNS cord-302115-r39ser2c 135 13 that that WDT cord-302115-r39ser2c 135 14 have have VBP cord-302115-r39ser2c 135 15 been be VBN cord-302115-r39ser2c 135 16 proved prove VBN cord-302115-r39ser2c 135 17 to to TO cord-302115-r39ser2c 135 18 reinforce reinforce VB cord-302115-r39ser2c 135 19 natural natural JJ cord-302115-r39ser2c 135 20 immunity immunity NN cord-302115-r39ser2c 135 21 in in IN cord-302115-r39ser2c 135 22 general general NN cord-302115-r39ser2c 135 23 . . . cord-302115-r39ser2c 136 1 This this DT cord-302115-r39ser2c 136 2 can can MD cord-302115-r39ser2c 136 3 be be VB cord-302115-r39ser2c 136 4 valid valid JJ cord-302115-r39ser2c 136 5 especially especially RB cord-302115-r39ser2c 136 6 considering consider VBG cord-302115-r39ser2c 136 7 that that IN cord-302115-r39ser2c 136 8 pneumococcus pneumococcus NNP cord-302115-r39ser2c 136 9 is be VBZ cord-302115-r39ser2c 136 10 also also RB cord-302115-r39ser2c 136 11 a a DT cord-302115-r39ser2c 136 12 frequent frequent JJ cord-302115-r39ser2c 136 13 cause cause NN cord-302115-r39ser2c 136 14 of of IN cord-302115-r39ser2c 136 15 co co NN cord-302115-r39ser2c 136 16 - - NN cord-302115-r39ser2c 136 17 infection infection NN cord-302115-r39ser2c 136 18 causing cause VBG cord-302115-r39ser2c 136 19 severe severe JJ cord-302115-r39ser2c 136 20 pneumonia pneumonia NN cord-302115-r39ser2c 136 21 and and CC cord-302115-r39ser2c 136 22 complications complication NNS cord-302115-r39ser2c 136 23 . . . cord-302115-r39ser2c 137 1 Given give VBN cord-302115-r39ser2c 137 2 the the DT cord-302115-r39ser2c 137 3 relevance relevance NN cord-302115-r39ser2c 137 4 of of IN cord-302115-r39ser2c 137 5 the the DT cord-302115-r39ser2c 137 6 local local JJ cord-302115-r39ser2c 137 7 immune immune JJ cord-302115-r39ser2c 137 8 response response NN cord-302115-r39ser2c 137 9 to to IN cord-302115-r39ser2c 137 10 SARS SARS NNP cord-302115-r39ser2c 137 11 - - HYPH cord-302115-r39ser2c 137 12 CoV-2 CoV-2 NNP cord-302115-r39ser2c 137 13 , , , cord-302115-r39ser2c 137 14 an an DT cord-302115-r39ser2c 137 15 immunization immunization NN cord-302115-r39ser2c 137 16 strategy strategy NN cord-302115-r39ser2c 137 17 based base VBN cord-302115-r39ser2c 137 18 on on IN cord-302115-r39ser2c 137 19 a a DT cord-302115-r39ser2c 137 20 mucosal mucosal JJ cord-302115-r39ser2c 137 21 vaccination vaccination NN cord-302115-r39ser2c 137 22 would would MD cord-302115-r39ser2c 137 23 assure assure VB cord-302115-r39ser2c 137 24 a a DT cord-302115-r39ser2c 137 25 higher high JJR cord-302115-r39ser2c 137 26 protection protection NN cord-302115-r39ser2c 137 27 . . . cord-302115-r39ser2c 138 1 This this DT cord-302115-r39ser2c 138 2 article article NN cord-302115-r39ser2c 138 3 is be VBZ cord-302115-r39ser2c 138 4 protected protect VBN cord-302115-r39ser2c 138 5 by by IN cord-302115-r39ser2c 138 6 copyright copyright NN cord-302115-r39ser2c 138 7 . . . cord-302115-r39ser2c 139 1 All all DT cord-302115-r39ser2c 139 2 rights right NNS cord-302115-r39ser2c 139 3 reserved reserve VBN cord-302115-r39ser2c 139 4 _SP cord-302115-r39ser2c 139 5 This this DT cord-302115-r39ser2c 139 6 article article NN cord-302115-r39ser2c 139 7 is be VBZ cord-302115-r39ser2c 139 8 protected protect VBN cord-302115-r39ser2c 139 9 by by IN cord-302115-r39ser2c 139 10 copyright copyright NN cord-302115-r39ser2c 139 11 . . . cord-302115-r39ser2c 140 1 All all DT cord-302115-r39ser2c 140 2 rights right NNS cord-302115-r39ser2c 140 3 reserved reserve VBD cord-302115-r39ser2c 140 4 _SP cord-302115-r39ser2c 140 5 A a DT cord-302115-r39ser2c 140 6 Novel Novel NNP cord-302115-r39ser2c 140 7 Coronavirus Coronavirus NNP cord-302115-r39ser2c 140 8 from from IN cord-302115-r39ser2c 140 9 Patients patient NNS cord-302115-r39ser2c 140 10 with with IN cord-302115-r39ser2c 140 11 Pneumonia Pneumonia NNP cord-302115-r39ser2c 140 12 in in IN cord-302115-r39ser2c 140 13 China China NNP cord-302115-r39ser2c 140 14 Detection Detection NNP cord-302115-r39ser2c 140 15 of of IN cord-302115-r39ser2c 140 16 2019 2019 CD cord-302115-r39ser2c 140 17 novel novel JJ cord-302115-r39ser2c 140 18 coronavirus coronavirus NN cord-302115-r39ser2c 140 19 ( ( -LRB- cord-302115-r39ser2c 140 20 2019-nCoV 2019-ncov CD cord-302115-r39ser2c 140 21 ) ) -RRB- cord-302115-r39ser2c 140 22 by by IN cord-302115-r39ser2c 140 23 real real JJ cord-302115-r39ser2c 140 24 - - HYPH cord-302115-r39ser2c 140 25 time time NN cord-302115-r39ser2c 140 26 RT RT NNP cord-302115-r39ser2c 140 27 - - HYPH cord-302115-r39ser2c 140 28 PCR PCR NNP cord-302115-r39ser2c 140 29 Identification Identification NNP cord-302115-r39ser2c 140 30 of of IN cord-302115-r39ser2c 140 31 a a DT cord-302115-r39ser2c 140 32 Novel Novel NNP cord-302115-r39ser2c 140 33 Coronavirus Coronavirus NNP cord-302115-r39ser2c 140 34 in in IN cord-302115-r39ser2c 140 35 Patients patient NNS cord-302115-r39ser2c 140 36 with with IN cord-302115-r39ser2c 140 37 Severe severe JJ cord-302115-r39ser2c 140 38 Acute acute JJ cord-302115-r39ser2c 140 39 Respiratory Respiratory NNP cord-302115-r39ser2c 140 40 Syndrome Syndrome NNP cord-302115-r39ser2c 140 41 Severe severe JJ cord-302115-r39ser2c 140 42 acute acute JJ cord-302115-r39ser2c 140 43 respiratory respiratory JJ cord-302115-r39ser2c 140 44 syndrome syndrome NN cord-302115-r39ser2c 140 45 - - HYPH cord-302115-r39ser2c 140 46 related relate VBN cord-302115-r39ser2c 140 47 coronavirus coronavirus NN cord-302115-r39ser2c 140 48 : : : cord-302115-r39ser2c 141 1 The the DT cord-302115-r39ser2c 141 2 species specie NNS cord-302115-r39ser2c 141 3 and and CC cord-302115-r39ser2c 141 4 its -PRON- PRP$ cord-302115-r39ser2c 141 5 viruses virus NNS cord-302115-r39ser2c 141 6 - - : cord-302115-r39ser2c 141 7 A a DT cord-302115-r39ser2c 141 8 statement statement NN cord-302115-r39ser2c 141 9 of of IN cord-302115-r39ser2c 141 10 the the DT cord-302115-r39ser2c 141 11 Coronavirus Coronavirus NNP cord-302115-r39ser2c 141 12 Study Study NNP cord-302115-r39ser2c 141 13 Group Group NNP cord-302115-r39ser2c 141 14 COVID-19 COVID-19 NNP cord-302115-r39ser2c 141 15 : : : cord-302115-r39ser2c 141 16 what what WP cord-302115-r39ser2c 141 17 is be VBZ cord-302115-r39ser2c 141 18 next next JJ cord-302115-r39ser2c 141 19 for for IN cord-302115-r39ser2c 141 20 public public JJ cord-302115-r39ser2c 141 21 health health NN cord-302115-r39ser2c 141 22 ? ? . cord-302115-r39ser2c 142 1 All all DT cord-302115-r39ser2c 142 2 rights right NNS cord-302115-r39ser2c 142 3 reserved reserve VBD cord-302115-r39ser2c 142 4 6 6 CD cord-302115-r39ser2c 142 5 -WHO -WHO -LRB- cord-302115-r39ser2c 142 6 pandemic pandemic JJ cord-302115-r39ser2c 142 7 statement statement NN cord-302115-r39ser2c 143 1 Evolving evolve VBG cord-302115-r39ser2c 143 2 epidemiology epidemiology NN cord-302115-r39ser2c 143 3 and and CC cord-302115-r39ser2c 143 4 transmission transmission NN cord-302115-r39ser2c 143 5 dynamics dynamic NNS cord-302115-r39ser2c 143 6 of of IN cord-302115-r39ser2c 143 7 coronavirus coronavirus NN cord-302115-r39ser2c 143 8 disease disease NN cord-302115-r39ser2c 143 9 2019 2019 CD cord-302115-r39ser2c 143 10 outside outside IN cord-302115-r39ser2c 143 11 Hubei Hubei NNP cord-302115-r39ser2c 143 12 province province NN cord-302115-r39ser2c 143 13 , , , cord-302115-r39ser2c 143 14 China China NNP cord-302115-r39ser2c 143 15 : : : cord-302115-r39ser2c 143 16 a a DT cord-302115-r39ser2c 143 17 descriptive descriptive JJ cord-302115-r39ser2c 143 18 and and CC cord-302115-r39ser2c 143 19 modelling modelling NN cord-302115-r39ser2c 143 20 study study NN cord-302115-r39ser2c 143 21 . . . cord-302115-r39ser2c 144 1 The the DT cord-302115-r39ser2c 144 2 Lancet Lancet NNP cord-302115-r39ser2c 144 3 , , , cord-302115-r39ser2c 144 4 Infectious Infectious NNP cord-302115-r39ser2c 144 5 Diseases Diseases NNPS cord-302115-r39ser2c 144 6 Clinical Clinical NNP cord-302115-r39ser2c 144 7 presentation presentation NN cord-302115-r39ser2c 144 8 and and CC cord-302115-r39ser2c 144 9 virological virological JJ cord-302115-r39ser2c 144 10 assessment assessment NN cord-302115-r39ser2c 144 11 of of IN cord-302115-r39ser2c 144 12 hospitalized hospitalize VBN cord-302115-r39ser2c 144 13 cases case NNS cord-302115-r39ser2c 144 14 of of IN cord-302115-r39ser2c 144 15 coronavirus coronavirus NN cord-302115-r39ser2c 144 16 disease disease NN cord-302115-r39ser2c 144 17 2019 2019 CD cord-302115-r39ser2c 144 18 in in IN cord-302115-r39ser2c 144 19 a a DT cord-302115-r39ser2c 144 20 travel travel NN cord-302115-r39ser2c 144 21 - - HYPH cord-302115-r39ser2c 144 22 associated associate VBN cord-302115-r39ser2c 144 23 transmission transmission NN cord-302115-r39ser2c 144 24 cluster cluster NN cord-302115-r39ser2c 144 25 . . . cord-302115-r39ser2c 145 1 medRxiv medRxiv NNP cord-302115-r39ser2c 145 2 preprint preprint NN cord-302115-r39ser2c 145 3 2020 2020 CD cord-302115-r39ser2c 146 1 Minimum minimum JJ cord-302115-r39ser2c 146 2 infective infective JJ cord-302115-r39ser2c 146 3 dose dose NN cord-302115-r39ser2c 146 4 of of IN cord-302115-r39ser2c 146 5 the the DT cord-302115-r39ser2c 146 6 major major JJ cord-302115-r39ser2c 146 7 human human JJ cord-302115-r39ser2c 146 8 respiratory respiratory NN cord-302115-r39ser2c 146 9 and and CC cord-302115-r39ser2c 146 10 enteric enteric JJ cord-302115-r39ser2c 146 11 viruses virus NNS cord-302115-r39ser2c 146 12 transmitted transmit VBN cord-302115-r39ser2c 146 13 through through IN cord-302115-r39ser2c 146 14 food food NN cord-302115-r39ser2c 146 15 and and CC cord-302115-r39ser2c 146 16 the the DT cord-302115-r39ser2c 146 17 environment environment NN cord-302115-r39ser2c 146 18 SARS SARS NNP cord-302115-r39ser2c 146 19 - - HYPH cord-302115-r39ser2c 146 20 CoV-2 CoV-2 NNP cord-302115-r39ser2c 146 21 viral viral JJ cord-302115-r39ser2c 146 22 load load NN cord-302115-r39ser2c 146 23 and and CC cord-302115-r39ser2c 146 24 the the DT cord-302115-r39ser2c 146 25 severity severity NN cord-302115-r39ser2c 146 26 of of IN cord-302115-r39ser2c 146 27 COVID-19 COVID-19 NNP cord-302115-r39ser2c 146 28 Clinical Clinical NNP cord-302115-r39ser2c 146 29 Characteristics Characteristics NNPS cord-302115-r39ser2c 146 30 of of IN cord-302115-r39ser2c 146 31 138 138 CD cord-302115-r39ser2c 146 32 Hospitalized hospitalize VBN cord-302115-r39ser2c 146 33 Patients patient NNS cord-302115-r39ser2c 146 34 With with IN cord-302115-r39ser2c 146 35 2019 2019 CD cord-302115-r39ser2c 146 36 Novel Novel NNP cord-302115-r39ser2c 146 37 Coronavirus Coronavirus NNP cord-302115-r39ser2c 146 38 - - HYPH cord-302115-r39ser2c 146 39 Infected infect VBN cord-302115-r39ser2c 146 40 Pneumonia Pneumonia NNP cord-302115-r39ser2c 146 41 in in IN cord-302115-r39ser2c 146 42 Wuhan Wuhan NNP cord-302115-r39ser2c 146 43 Incubation Incubation NNP cord-302115-r39ser2c 146 44 Period Period NNP cord-302115-r39ser2c 146 45 and and CC cord-302115-r39ser2c 146 46 Other other JJ cord-302115-r39ser2c 146 47 Epidemiological epidemiological JJ cord-302115-r39ser2c 146 48 Characteristics characteristic NNS cord-302115-r39ser2c 146 49 of of IN cord-302115-r39ser2c 146 50 2019 2019 CD cord-302115-r39ser2c 146 51 Novel Novel NNP cord-302115-r39ser2c 146 52 Coronavirus Coronavirus NNP cord-302115-r39ser2c 146 53 Infections Infections NNPS cord-302115-r39ser2c 146 54 with with IN cord-302115-r39ser2c 146 55 Right Right NNP cord-302115-r39ser2c 146 56 Truncation truncation NN cord-302115-r39ser2c 146 57 : : : cord-302115-r39ser2c 146 58 A a DT cord-302115-r39ser2c 146 59 Statistical Statistical NNP cord-302115-r39ser2c 146 60 Analysis Analysis NNP cord-302115-r39ser2c 146 61 of of IN cord-302115-r39ser2c 146 62 Publicly publicly RB cord-302115-r39ser2c 146 63 Available Available NNP cord-302115-r39ser2c 146 64 Case Case NNP cord-302115-r39ser2c 146 65 Data Data NNP cord-302115-r39ser2c 146 66 SARS SARS NNP cord-302115-r39ser2c 146 67 - - HYPH cord-302115-r39ser2c 146 68 CoV-2 CoV-2 NNP cord-302115-r39ser2c 146 69 viral viral JJ cord-302115-r39ser2c 146 70 load load NN cord-302115-r39ser2c 146 71 in in IN cord-302115-r39ser2c 146 72 upper upper JJ cord-302115-r39ser2c 146 73 respiratory respiratory JJ cord-302115-r39ser2c 146 74 specimens specimen NNS cord-302115-r39ser2c 146 75 of of IN cord-302115-r39ser2c 146 76 infected infected JJ cord-302115-r39ser2c 146 77 patients patient NNS cord-302115-r39ser2c 146 78 Chest Chest NNP cord-302115-r39ser2c 146 79 CT CT NNP cord-302115-r39ser2c 146 80 Findings Findings NNPS cord-302115-r39ser2c 146 81 in in IN cord-302115-r39ser2c 146 82 Cases case NNS cord-302115-r39ser2c 146 83 from from IN cord-302115-r39ser2c 146 84 the the DT cord-302115-r39ser2c 146 85 Cruise Cruise NNP cord-302115-r39ser2c 146 86 Ship Ship NNP cord-302115-r39ser2c 146 87 " " '' cord-302115-r39ser2c 146 88 Diamond Diamond NNP cord-302115-r39ser2c 146 89 Princess Princess NNP cord-302115-r39ser2c 146 90 Clinical clinical JJ cord-302115-r39ser2c 146 91 course course NN cord-302115-r39ser2c 146 92 and and CC cord-302115-r39ser2c 146 93 risk risk NN cord-302115-r39ser2c 146 94 factors factor NNS cord-302115-r39ser2c 146 95 for for IN cord-302115-r39ser2c 146 96 mortality mortality NN cord-302115-r39ser2c 146 97 of of IN cord-302115-r39ser2c 146 98 adult adult NN cord-302115-r39ser2c 146 99 inpatients inpatient NNS cord-302115-r39ser2c 146 100 with with IN cord-302115-r39ser2c 146 101 COVID-19 COVID-19 NNP cord-302115-r39ser2c 146 102 in in IN cord-302115-r39ser2c 146 103 Wuhan Wuhan NNP cord-302115-r39ser2c 146 104 , , , cord-302115-r39ser2c 146 105 China China NNP cord-302115-r39ser2c 146 106 : : : cord-302115-r39ser2c 146 107 a a DT cord-302115-r39ser2c 146 108 retrospective retrospective JJ cord-302115-r39ser2c 146 109 cohort cohort NN cord-302115-r39ser2c 146 110 study study NN cord-302115-r39ser2c 146 111 Organ Organ NNP cord-302115-r39ser2c 146 112 distribution distribution NN cord-302115-r39ser2c 146 113 of of IN cord-302115-r39ser2c 146 114 severe severe JJ cord-302115-r39ser2c 146 115 acute acute JJ cord-302115-r39ser2c 146 116 respiratory respiratory JJ cord-302115-r39ser2c 146 117 syndrome syndrome NN cord-302115-r39ser2c 146 118 ( ( -LRB- cord-302115-r39ser2c 146 119 SARS SARS NNP cord-302115-r39ser2c 146 120 ) ) -RRB- cord-302115-r39ser2c 146 121 associated associate VBD cord-302115-r39ser2c 146 122 coronavirus coronavirus NN cord-302115-r39ser2c 146 123 ( ( -LRB- cord-302115-r39ser2c 146 124 SARS SARS NNP cord-302115-r39ser2c 146 125 - - HYPH cord-302115-r39ser2c 146 126 CoV CoV NNP cord-302115-r39ser2c 146 127 ) ) -RRB- cord-302115-r39ser2c 146 128 in in IN cord-302115-r39ser2c 146 129 SARS SARS NNP cord-302115-r39ser2c 146 130 patients patient NNS cord-302115-r39ser2c 146 131 : : : cord-302115-r39ser2c 146 132 implications implication NNS cord-302115-r39ser2c 146 133 for for IN cord-302115-r39ser2c 146 134 Accepted Accepted NNP cord-302115-r39ser2c 146 135 Article Article NNP cord-302115-r39ser2c 147 1 This this DT cord-302115-r39ser2c 147 2 article article NN cord-302115-r39ser2c 147 3 is be VBZ cord-302115-r39ser2c 147 4 protected protect VBN cord-302115-r39ser2c 147 5 by by IN cord-302115-r39ser2c 147 6 copyright copyright NN cord-302115-r39ser2c 147 7 . . . cord-302115-r39ser2c 148 1 All all DT cord-302115-r39ser2c 148 2 rights right NNS cord-302115-r39ser2c 148 3 reserved reserve VBN cord-302115-r39ser2c 148 4 pathogenesis pathogenesis NN cord-302115-r39ser2c 148 5 and and CC cord-302115-r39ser2c 148 6 virus virus NN cord-302115-r39ser2c 148 7 transmission transmission NN cord-302115-r39ser2c 148 8 pathways pathway NNS cord-302115-r39ser2c 148 9 Exploring explore VBG cord-302115-r39ser2c 148 10 the the DT cord-302115-r39ser2c 148 11 pathogenesis pathogenesis NN cord-302115-r39ser2c 148 12 of of IN cord-302115-r39ser2c 148 13 severe severe JJ cord-302115-r39ser2c 148 14 acute acute JJ cord-302115-r39ser2c 148 15 respiratory respiratory JJ cord-302115-r39ser2c 148 16 syndrome syndrome NN cord-302115-r39ser2c 148 17 ( ( -LRB- cord-302115-r39ser2c 148 18 SARS SARS NNP cord-302115-r39ser2c 148 19 ) ) -RRB- cord-302115-r39ser2c 148 20 : : : cord-302115-r39ser2c 148 21 the the DT cord-302115-r39ser2c 148 22 tissue tissue NN cord-302115-r39ser2c 148 23 distribution distribution NN cord-302115-r39ser2c 148 24 of of IN cord-302115-r39ser2c 148 25 the the DT cord-302115-r39ser2c 148 26 coronavirus coronavirus NN cord-302115-r39ser2c 148 27 ( ( -LRB- cord-302115-r39ser2c 148 28 SARS SARS NNP cord-302115-r39ser2c 148 29 - - HYPH cord-302115-r39ser2c 148 30 CoV CoV NNP cord-302115-r39ser2c 148 31 ) ) -RRB- cord-302115-r39ser2c 148 32 and and CC cord-302115-r39ser2c 148 33 its -PRON- PRP$ cord-302115-r39ser2c 148 34 putative putative JJ cord-302115-r39ser2c 148 35 receptor receptor NN cord-302115-r39ser2c 148 36 , , , cord-302115-r39ser2c 148 37 angiotensin angiotensin NN cord-302115-r39ser2c 148 38 - - HYPH cord-302115-r39ser2c 148 39 converting convert VBG cord-302115-r39ser2c 148 40 enzyme enzyme NN cord-302115-r39ser2c 148 41 2 2 CD cord-302115-r39ser2c 148 42 ( ( -LRB- cord-302115-r39ser2c 148 43 ACE2 ACE2 NNP cord-302115-r39ser2c 148 44 ) ) -RRB- cord-302115-r39ser2c 149 1 Accessible accessible JJ cord-302115-r39ser2c 149 2 surface surface NN cord-302115-r39ser2c 149 3 glycopeptide glycopeptide NN cord-302115-r39ser2c 149 4 motifs motif NNS cord-302115-r39ser2c 149 5 on on IN cord-302115-r39ser2c 149 6 Spike Spike NNP cord-302115-r39ser2c 149 7 glycoprotein glycoprotein NN cord-302115-r39ser2c 149 8 of of IN cord-302115-r39ser2c 149 9 2019-nCoV 2019-ncov CD cord-302115-r39ser2c 149 10 : : : cord-302115-r39ser2c 150 1 implications implication NNS cord-302115-r39ser2c 150 2 on on IN cord-302115-r39ser2c 150 3 vaccination vaccination NN cord-302115-r39ser2c 150 4 and and CC cord-302115-r39ser2c 150 5 antibody antibody NN cord-302115-r39ser2c 150 6 therapeutics therapeutic NNS cord-302115-r39ser2c 150 7 . . . cord-302115-r39ser2c 151 1 Preprints preprint NNS cord-302115-r39ser2c 151 2 . . . cord-302115-r39ser2c 152 1 2020 2020 CD cord-302115-r39ser2c 153 1 Profiling profile VBG cord-302115-r39ser2c 153 2 Early early JJ cord-302115-r39ser2c 153 3 Humoral Humoral NNP cord-302115-r39ser2c 153 4 Response response NN cord-302115-r39ser2c 153 5 to to TO cord-302115-r39ser2c 153 6 Diagnose diagnose VB cord-302115-r39ser2c 153 7 Novel Novel NNP cord-302115-r39ser2c 153 8 Coronavirus Coronavirus NNP cord-302115-r39ser2c 153 9 Disease Disease NNP cord-302115-r39ser2c 153 10 ( ( -LRB- cord-302115-r39ser2c 153 11 COVID-19 COVID-19 NNP cord-302115-r39ser2c 153 12 ) ) -RRB- cord-302115-r39ser2c 154 1 The the DT cord-302115-r39ser2c 154 2 effectiveness effectiveness NN cord-302115-r39ser2c 154 3 of of IN cord-302115-r39ser2c 154 4 convalescent convalescent JJ cord-302115-r39ser2c 154 5 plasma plasma NN cord-302115-r39ser2c 154 6 and and CC cord-302115-r39ser2c 154 7 hyperimmune hyperimmune NNP cord-302115-r39ser2c 154 8 immunoglobulin immunoglobulin NN cord-302115-r39ser2c 154 9 for for IN cord-302115-r39ser2c 154 10 the the DT cord-302115-r39ser2c 154 11 treatment treatment NN cord-302115-r39ser2c 154 12 of of IN cord-302115-r39ser2c 154 13 severe severe JJ cord-302115-r39ser2c 154 14 acute acute JJ cord-302115-r39ser2c 154 15 respiratory respiratory JJ cord-302115-r39ser2c 154 16 infections infection NNS cord-302115-r39ser2c 154 17 of of IN cord-302115-r39ser2c 154 18 viral viral JJ cord-302115-r39ser2c 154 19 etiology etiology NN cord-302115-r39ser2c 154 20 : : : cord-302115-r39ser2c 154 21 a a DT cord-302115-r39ser2c 154 22 systematic systematic JJ cord-302115-r39ser2c 154 23 review review NN cord-302115-r39ser2c 154 24 and and CC cord-302115-r39ser2c 154 25 exploratory exploratory JJ cord-302115-r39ser2c 154 26 metaanalysis metaanalysis NN cord-302115-r39ser2c 154 27 38 38 CD cord-302115-r39ser2c 154 28 -Casadevall -Casadevall . cord-302115-r39ser2c 155 1 A a LS cord-302115-r39ser2c 155 2 , , , cord-302115-r39ser2c 155 3 Pirofski Pirofski NNP cord-302115-r39ser2c 155 4 L. L. NNP cord-302115-r39ser2c 156 1 The the DT cord-302115-r39ser2c 156 2 convalescent convalescent JJ cord-302115-r39ser2c 156 3 sera sera NN cord-302115-r39ser2c 156 4 option option NN cord-302115-r39ser2c 156 5 for for IN cord-302115-r39ser2c 156 6 containing contain VBG cord-302115-r39ser2c 156 7 COVID-19 COVID-19 NNP cord-302115-r39ser2c 156 8 Identify identify VB cord-302115-r39ser2c 156 9 - - HYPH cord-302115-r39ser2c 156 10 Isolate isolate VB cord-302115-r39ser2c 156 11 - - HYPH cord-302115-r39ser2c 156 12 Inform inform NN cord-302115-r39ser2c 156 13 : : : cord-302115-r39ser2c 156 14 a a DT cord-302115-r39ser2c 156 15 modified modify VBN cord-302115-r39ser2c 156 16 tool tool NN cord-302115-r39ser2c 156 17 for for IN cord-302115-r39ser2c 156 18 initial initial JJ cord-302115-r39ser2c 156 19 detection detection NN cord-302115-r39ser2c 156 20 and and CC cord-302115-r39ser2c 156 21 management management NN cord-302115-r39ser2c 156 22 of of IN cord-302115-r39ser2c 156 23 Middle Middle NNP cord-302115-r39ser2c 156 24 East East NNP cord-302115-r39ser2c 156 25 Respiratory Respiratory NNP cord-302115-r39ser2c 156 26 Syndrome Syndrome NNP cord-302115-r39ser2c 156 27 patients patient NNS cord-302115-r39ser2c 156 28 in in IN cord-302115-r39ser2c 156 29 the the DT cord-302115-r39ser2c 156 30 emergency emergency NN cord-302115-r39ser2c 156 31 department department NN cord-302115-r39ser2c 156 32 Effectiveness Effectiveness NNP cord-302115-r39ser2c 156 33 of of IN cord-302115-r39ser2c 156 34 convalescent convalescent JJ cord-302115-r39ser2c 156 35 plasma plasma NN cord-302115-r39ser2c 156 36 therapy therapy NN cord-302115-r39ser2c 156 37 in in IN cord-302115-r39ser2c 156 38 severe severe JJ cord-302115-r39ser2c 156 39 COVID-19 COVID-19 NNP cord-302115-r39ser2c 156 40 patients patient NNS cord-302115-r39ser2c 156 41 Treatment Treatment NNP cord-302115-r39ser2c 156 42 of of IN cord-302115-r39ser2c 156 43 5 5 CD cord-302115-r39ser2c 157 1 Critically critically RB cord-302115-r39ser2c 157 2 Ill Ill NNP cord-302115-r39ser2c 157 3 Patients Patients NNPS cord-302115-r39ser2c 157 4 With with IN cord-302115-r39ser2c 157 5 COVID-19 COVID-19 NNP cord-302115-r39ser2c 158 1 With with IN cord-302115-r39ser2c 158 2 Convalescent Convalescent NNP cord-302115-r39ser2c 158 3 Plasma Plasma NNP cord-302115-r39ser2c 159 1 Beyond beyond IN cord-302115-r39ser2c 159 2 the the DT cord-302115-r39ser2c 159 3 assistance assistance NN cord-302115-r39ser2c 159 4 : : : cord-302115-r39ser2c 159 5 additional additional JJ cord-302115-r39ser2c 159 6 exposure exposure NN cord-302115-r39ser2c 159 7 situations situation NNS cord-302115-r39ser2c 159 8 to to TO cord-302115-r39ser2c 159 9 COVID-19 covid-19 VB cord-302115-r39ser2c 159 10 for for IN cord-302115-r39ser2c 159 11 healthcare healthcare NN cord-302115-r39ser2c 159 12 workers worker NNS cord-302115-r39ser2c 159 13 Li Li NNP cord-302115-r39ser2c 159 14 Wenliang Wenliang NNP cord-302115-r39ser2c 159 15 , , , cord-302115-r39ser2c 159 16 a a DT cord-302115-r39ser2c 159 17 face face NN cord-302115-r39ser2c 159 18 to to IN cord-302115-r39ser2c 159 19 the the DT cord-302115-r39ser2c 159 20 frontline frontline JJ cord-302115-r39ser2c 159 21 healthcare healthcare NN cord-302115-r39ser2c 159 22 worker worker NN cord-302115-r39ser2c 159 23 . . . cord-302115-r39ser2c 160 1 The the DT cord-302115-r39ser2c 160 2 first first JJ cord-302115-r39ser2c 160 3 doctor doctor NN cord-302115-r39ser2c 160 4 to to TO cord-302115-r39ser2c 160 5 notify notify VB cord-302115-r39ser2c 160 6 the the DT cord-302115-r39ser2c 160 7 emergence emergence NN cord-302115-r39ser2c 160 8 of of IN cord-302115-r39ser2c 160 9 the the DT cord-302115-r39ser2c 160 10 SARS SARS NNP cord-302115-r39ser2c 160 11 - - HYPH cord-302115-r39ser2c 160 12 CoV-2 CoV-2 NNP cord-302115-r39ser2c 160 13 , , , cord-302115-r39ser2c 160 14 ( ( -LRB- cord-302115-r39ser2c 160 15 COVID-19 COVID-19 NNP cord-302115-r39ser2c 160 16 ) ) -RRB- cord-302115-r39ser2c 160 17 , , , cord-302115-r39ser2c 160 18 outbreak outbreak NN cord-302115-r39ser2c 160 19 Viral viral JJ cord-302115-r39ser2c 160 20 loads load NNS cord-302115-r39ser2c 160 21 in in IN cord-302115-r39ser2c 160 22 clinical clinical JJ cord-302115-r39ser2c 160 23 specimens specimen NNS cord-302115-r39ser2c 160 24 and and CC cord-302115-r39ser2c 160 25 SARS SARS NNP cord-302115-r39ser2c 160 26 manifestations manifestation NNS cord-302115-r39ser2c 161 1 Influenza Influenza NNP cord-302115-r39ser2c 161 2 Infectious Infectious NNP cord-302115-r39ser2c 161 3 Dose Dose NNP cord-302115-r39ser2c 161 4 May May NNP cord-302115-r39ser2c 161 5 Explain explain VB cord-302115-r39ser2c 161 6 the the DT cord-302115-r39ser2c 161 7 High High NNP cord-302115-r39ser2c 161 8 Mortality Mortality NNP cord-302115-r39ser2c 161 9 of of IN cord-302115-r39ser2c 161 10 the the DT cord-302115-r39ser2c 161 11 Second second JJ cord-302115-r39ser2c 161 12 and and CC cord-302115-r39ser2c 161 13 Third Third NNP cord-302115-r39ser2c 161 14 Wave Wave NNP cord-302115-r39ser2c 161 15 of of IN cord-302115-r39ser2c 161 16 1918 1918 CD cord-302115-r39ser2c 161 17 - - SYM cord-302115-r39ser2c 161 18 1919 1919 CD cord-302115-r39ser2c 161 19 Influenza Influenza NNP cord-302115-r39ser2c 161 20 Pandemic Pandemic NNP cord-302115-r39ser2c 161 21 Summary Summary NNP cord-302115-r39ser2c 161 22 of of IN cord-302115-r39ser2c 161 23 a a DT cord-302115-r39ser2c 161 24 Report Report NNP cord-302115-r39ser2c 161 25 of of IN cord-302115-r39ser2c 161 26 72 72 CD cord-302115-r39ser2c 161 27 314 314 CD cord-302115-r39ser2c 161 28 Cases case NNS cord-302115-r39ser2c 161 29 From from IN cord-302115-r39ser2c 161 30 the the DT cord-302115-r39ser2c 161 31 Chinese Chinese NNP cord-302115-r39ser2c 161 32 Center Center NNP cord-302115-r39ser2c 161 33 for for IN cord-302115-r39ser2c 161 34 Disease Disease NNP cord-302115-r39ser2c 161 35 Control Control NNP cord-302115-r39ser2c 161 36 and and CC cord-302115-r39ser2c 161 37 Prevention Prevention NNP cord-302115-r39ser2c 161 38 Epidemiological epidemiological JJ cord-302115-r39ser2c 161 39 characteristics characteristic NNS cord-302115-r39ser2c 161 40 of of IN cord-302115-r39ser2c 161 41 2143 2143 CD cord-302115-r39ser2c 161 42 pediatric pediatric JJ cord-302115-r39ser2c 161 43 patients patient NNS cord-302115-r39ser2c 161 44 with with IN cord-302115-r39ser2c 161 45 2019 2019 CD cord-302115-r39ser2c 161 46 coronavirus coronavirus NN cord-302115-r39ser2c 161 47 disease disease NN cord-302115-r39ser2c 161 48 in in IN cord-302115-r39ser2c 161 49 China China NNP cord-302115-r39ser2c 161 50 Disparities Disparities NNPS cord-302115-r39ser2c 161 51 in in IN cord-302115-r39ser2c 161 52 Age Age NNP cord-302115-r39ser2c 161 53 - - HYPH cord-302115-r39ser2c 161 54 Specific Specific NNP cord-302115-r39ser2c 161 55 Morbidity Morbidity NNP cord-302115-r39ser2c 161 56 and and CC cord-302115-r39ser2c 161 57 Mortality mortality NN cord-302115-r39ser2c 161 58 from from IN cord-302115-r39ser2c 161 59 SARS SARS NNP cord-302115-r39ser2c 161 60 - - HYPH cord-302115-r39ser2c 161 61 CoV-2 CoV-2 NNP cord-302115-r39ser2c 161 62 in in IN cord-302115-r39ser2c 161 63 China China NNP cord-302115-r39ser2c 161 64 and and CC cord-302115-r39ser2c 161 65 the the DT cord-302115-r39ser2c 161 66 Republic Republic NNP cord-302115-r39ser2c 161 67 of of IN cord-302115-r39ser2c 161 68 Korea Korea NNP cord-302115-r39ser2c 161 69 Baseline Baseline NNP cord-302115-r39ser2c 161 70 Characteristics Characteristics NNP cord-302115-r39ser2c 161 71 and and CC cord-302115-r39ser2c 161 72 Outcomes Outcomes NNPS cord-302115-r39ser2c 161 73 of of IN cord-302115-r39ser2c 161 74 1591 1591 CD cord-302115-r39ser2c 161 75 Patients patient NNS cord-302115-r39ser2c 161 76 Infected infect VBN cord-302115-r39ser2c 161 77 . . . cord-302115-r39ser2c 162 1 With with IN cord-302115-r39ser2c 162 2 SARS SARS NNP cord-302115-r39ser2c 162 3 - - HYPH cord-302115-r39ser2c 162 4 CoV-2 CoV-2 NNP cord-302115-r39ser2c 162 5 Admitted admit VBD cord-302115-r39ser2c 162 6 to to IN cord-302115-r39ser2c 162 7 ICUs ICUs NNP cord-302115-r39ser2c 162 8 of of IN cord-302115-r39ser2c 162 9 the the DT cord-302115-r39ser2c 162 10 Lombardy Lombardy NNP cord-302115-r39ser2c 162 11 Region Region NNP cord-302115-r39ser2c 162 12 Accepted Accepted NNP cord-302115-r39ser2c 162 13 Article Article NNP cord-302115-r39ser2c 162 14 and and CC cord-302115-r39ser2c 162 15 the the DT cord-302115-r39ser2c 162 16 COVID-19 COVID-19 NNP cord-302115-r39ser2c 162 17 Susceptibility Susceptibility NNP cord-302115-r39ser2c 162 18 . . . cord-302115-r39ser2c 163 1 medRxiv medRxiv NNP cord-302115-r39ser2c 163 2 PREPRINT PREPRINT NNP cord-302115-r39ser2c 164 1 The the DT cord-302115-r39ser2c 164 2 compelling compelling JJ cord-302115-r39ser2c 164 3 link link NN cord-302115-r39ser2c 164 4 between between IN cord-302115-r39ser2c 164 5 physical physical JJ cord-302115-r39ser2c 164 6 activity activity NN cord-302115-r39ser2c 164 7 and and CC cord-302115-r39ser2c 164 8 the the DT cord-302115-r39ser2c 164 9 body body NN cord-302115-r39ser2c 164 10 's 's POS cord-302115-r39ser2c 164 11 defense defense NN cord-302115-r39ser2c 164 12 system system NN cord-302115-r39ser2c 165 1 Arabatzis Arabatzis NNP cord-302115-r39ser2c 165 2 K. K. NNP cord-302115-r39ser2c 166 1 -Infectious -infectious JJ cord-302115-r39ser2c 166 2 episodes episode NNS cord-302115-r39ser2c 166 3 in in IN cord-302115-r39ser2c 166 4 runners runner NNS cord-302115-r39ser2c 166 5 before before IN cord-302115-r39ser2c 166 6 and and CC cord-302115-r39ser2c 166 7 after after IN cord-302115-r39ser2c 166 8 the the DT cord-302115-r39ser2c 166 9 Los Los NNP cord-302115-r39ser2c 166 10 Angeles Angeles NNP cord-302115-r39ser2c 166 11 Marathon Marathon NNP cord-302115-r39ser2c 166 12 A a DT cord-302115-r39ser2c 166 13 familial familial JJ cord-302115-r39ser2c 166 14 cluster cluster NN cord-302115-r39ser2c 166 15 of of IN cord-302115-r39ser2c 166 16 pneumonia pneumonia NN cord-302115-r39ser2c 166 17 associated associate VBN cord-302115-r39ser2c 166 18 with with IN cord-302115-r39ser2c 166 19 the the DT cord-302115-r39ser2c 166 20 2019 2019 CD cord-302115-r39ser2c 166 21 novel novel NN cord-302115-r39ser2c 166 22 coronavirus coronavirus NN cord-302115-r39ser2c 166 23 indicating indicate VBG cord-302115-r39ser2c 166 24 person person NN cord-302115-r39ser2c 166 25 - - HYPH cord-302115-r39ser2c 166 26 to to IN cord-302115-r39ser2c 166 27 - - HYPH cord-302115-r39ser2c 166 28 person person NN cord-302115-r39ser2c 166 29 transmission transmission NN cord-302115-r39ser2c 166 30 : : : cord-302115-r39ser2c 166 31 a a DT cord-302115-r39ser2c 166 32 study study NN cord-302115-r39ser2c 166 33 of of IN cord-302115-r39ser2c 166 34 a a DT cord-302115-r39ser2c 166 35 family family NN cord-302115-r39ser2c 166 36 cluster cluster NN cord-302115-r39ser2c 166 37 Common common JJ cord-302115-r39ser2c 166 38 sports sport NNS cord-302115-r39ser2c 166 39 - - HYPH cord-302115-r39ser2c 166 40 related relate VBN cord-302115-r39ser2c 166 41 infections infection NNS cord-302115-r39ser2c 166 42 : : : cord-302115-r39ser2c 166 43 a a DT cord-302115-r39ser2c 166 44 review review NN cord-302115-r39ser2c 166 45 on on IN cord-302115-r39ser2c 166 46 clinical clinical JJ cord-302115-r39ser2c 166 47 pictures picture NNS cord-302115-r39ser2c 166 48 , , , cord-302115-r39ser2c 166 49 management management NN cord-302115-r39ser2c 166 50 and and CC cord-302115-r39ser2c 166 51 time time NN cord-302115-r39ser2c 166 52 to to TO cord-302115-r39ser2c 166 53 return return VB cord-302115-r39ser2c 166 54 to to IN cord-302115-r39ser2c 166 55 sports sport NNS cord-302115-r39ser2c 166 56 70 70 CD cord-302115-r39ser2c 166 57 -Nehlsen -Nehlsen NNP cord-302115-r39ser2c 166 58 - - HYPH cord-302115-r39ser2c 166 59 Cannarella Cannarella NNP cord-302115-r39ser2c 166 60 SL SL NNP cord-302115-r39ser2c 166 61 , , , cord-302115-r39ser2c 166 62 Nieman Nieman NNP cord-302115-r39ser2c 166 63 DC DC NNP cord-302115-r39ser2c 166 64 , , , cord-302115-r39ser2c 166 65 Fagoaga Fagoaga NNP cord-302115-r39ser2c 166 66 OR OR NNP cord-302115-r39ser2c 166 67 , , , cord-302115-r39ser2c 166 68 et et NNP cord-302115-r39ser2c 166 69 al al NNP cord-302115-r39ser2c 166 70 . . . cord-302115-r39ser2c 167 1 Saliva saliva NN cord-302115-r39ser2c 167 2 immunoglobulins immunoglobulin NNS cord-302115-r39ser2c 167 3 in in IN cord-302115-r39ser2c 167 4 elite elite JJ cord-302115-r39ser2c 167 5 women woman NNS cord-302115-r39ser2c 167 6 rowers rower NNS cord-302115-r39ser2c 167 7 Exercise Exercise NNP cord-302115-r39ser2c 167 8 , , , cord-302115-r39ser2c 167 9 immunology immunology NN cord-302115-r39ser2c 167 10 and and CC cord-302115-r39ser2c 167 11 upper upper JJ cord-302115-r39ser2c 167 12 respiratory respiratory JJ cord-302115-r39ser2c 167 13 tract tract NN cord-302115-r39ser2c 167 14 infections infection NNS cord-302115-r39ser2c 168 1 All all DT cord-302115-r39ser2c 168 2 rights right NNS cord-302115-r39ser2c 168 3 reserved reserve VBD cord-302115-r39ser2c 168 4 72 72 CD cord-302115-r39ser2c 169 1 -Bouhuys -bouhuy VBZ cord-302115-r39ser2c 169 2 A. A. NNP cord-302115-r39ser2c 170 1 The the DT cord-302115-r39ser2c 170 2 physiology physiology NN cord-302115-r39ser2c 170 3 of of IN cord-302115-r39ser2c 170 4 Breathing breathing NN cord-302115-r39ser2c 170 5 . . . cord-302115-r39ser2c 171 1 Grune Grune NNP cord-302115-r39ser2c 171 2 & & CC cord-302115-r39ser2c 171 3 Stratton Stratton NNP cord-302115-r39ser2c 171 4 . . NNP cord-302115-r39ser2c 171 5 1977 1977 CD cord-302115-r39ser2c 171 6 . . . cord-302115-r39ser2c 172 1 New New NNP cord-302115-r39ser2c 172 2 York.p.60 York.p.60 NNP cord-302115-r39ser2c 172 3 - - HYPH cord-302115-r39ser2c 172 4 98 98 CD cord-302115-r39ser2c 172 5 73 73 CD cord-302115-r39ser2c 173 1 -Raymond -Raymond : cord-302115-r39ser2c 173 2 Tellier Tellier NNP cord-302115-r39ser2c 173 3 -Review -Review : cord-302115-r39ser2c 173 4 of of IN cord-302115-r39ser2c 173 5 Aerosol Aerosol NNP cord-302115-r39ser2c 173 6 Transmission Transmission NNP cord-302115-r39ser2c 173 7 of of IN cord-302115-r39ser2c 173 8 Influenza Influenza NNP cord-302115-r39ser2c 173 9 A A NNP cord-302115-r39ser2c 173 10 Virus virus NN cord-302115-r39ser2c 173 11 74 74 CD cord-302115-r39ser2c 174 1 -Nieman -Nieman NNP cord-302115-r39ser2c 174 2 DC DC NNP cord-302115-r39ser2c 174 3 . . . cord-302115-r39ser2c 175 1 Exercise exercise NN cord-302115-r39ser2c 175 2 , , , cord-302115-r39ser2c 175 3 upper upper JJ cord-302115-r39ser2c 175 4 respiratory respiratory JJ cord-302115-r39ser2c 175 5 tract tract NN cord-302115-r39ser2c 175 6 infection infection NN cord-302115-r39ser2c 175 7 , , , cord-302115-r39ser2c 175 8 and and CC cord-302115-r39ser2c 175 9 the the DT cord-302115-r39ser2c 175 10 immune immune JJ cord-302115-r39ser2c 175 11 system system NN cord-302115-r39ser2c 175 12 Favorable favorable JJ cord-302115-r39ser2c 175 13 outcome outcome NN cord-302115-r39ser2c 175 14 of of IN cord-302115-r39ser2c 175 15 COVID19 COVID19 NNP cord-302115-r39ser2c 175 16 in in IN cord-302115-r39ser2c 175 17 two two CD cord-302115-r39ser2c 175 18 patients patient NNS cord-302115-r39ser2c 175 19 with with IN cord-302115-r39ser2c 175 20 X x NN cord-302115-r39ser2c 175 21 - - HYPH cord-302115-r39ser2c 175 22 linked link VBN cord-302115-r39ser2c 175 23 agammaglobulinemia agammaglobulinemia NN cord-302115-r39ser2c 175 24 A a DT cord-302115-r39ser2c 175 25 possible possible JJ cord-302115-r39ser2c 175 26 role role NN cord-302115-r39ser2c 175 27 for for IN cord-302115-r39ser2c 175 28 B b NN cord-302115-r39ser2c 175 29 cells cell NNS cord-302115-r39ser2c 175 30 in in IN cord-302115-r39ser2c 175 31 COVID-19 COVID-19 NNP cord-302115-r39ser2c 175 32 ? ? . cord-302115-r39ser2c 175 33 : : : cord-302115-r39ser2c 176 1 Lesson lesson NN cord-302115-r39ser2c 176 2 from from IN cord-302115-r39ser2c 176 3 patients patient NNS cord-302115-r39ser2c 176 4 with with IN cord-302115-r39ser2c 176 5 Agammaglobulinemia Agammaglobulinemia NNP cord-302115-r39ser2c 176 6 Defense Defense NNP cord-302115-r39ser2c 176 7 mechanisms mechanism NNS cord-302115-r39ser2c 176 8 against against IN cord-302115-r39ser2c 176 9 influenza influenza NN cord-302115-r39ser2c 176 10 virus virus NN cord-302115-r39ser2c 176 11 infection infection NN cord-302115-r39ser2c 176 12 in in IN cord-302115-r39ser2c 176 13 the the DT cord-302115-r39ser2c 176 14 respiratory respiratory JJ cord-302115-r39ser2c 176 15 tract tract NN cord-302115-r39ser2c 176 16 mucosa mucosa NN cord-302115-r39ser2c 176 17 Invariance invariance NN cord-302115-r39ser2c 176 18 and and CC cord-302115-r39ser2c 176 19 restriction restriction NN cord-302115-r39ser2c 176 20 toward toward IN cord-302115-r39ser2c 176 21 a a DT cord-302115-r39ser2c 176 22 limited limited JJ cord-302115-r39ser2c 176 23 set set NN cord-302115-r39ser2c 176 24 of of IN cord-302115-r39ser2c 176 25 self self NN cord-302115-r39ser2c 176 26 - - HYPH cord-302115-r39ser2c 176 27 antigens antigen NNS cord-302115-r39ser2c 176 28 characterize characterize VBP cord-302115-r39ser2c 176 29 neonatal neonatal JJ cord-302115-r39ser2c 176 30 IgM IgM NNP cord-302115-r39ser2c 176 31 antibody antibody NN cord-302115-r39ser2c 176 32 repertoires repertoire NNS cord-302115-r39ser2c 176 33 and and CC cord-302115-r39ser2c 176 34 prevail prevail VBP cord-302115-r39ser2c 176 35 in in IN cord-302115-r39ser2c 176 36 autoreactive autoreactive JJ cord-302115-r39ser2c 176 37 repertoires repertoire NNS cord-302115-r39ser2c 176 38 of of IN cord-302115-r39ser2c 176 39 healthy healthy JJ cord-302115-r39ser2c 176 40 adults adult NNS cord-302115-r39ser2c 177 1 Natural natural JJ cord-302115-r39ser2c 177 2 autoantibodies autoantibody NNS cord-302115-r39ser2c 177 3 Accepted accept VBD cord-302115-r39ser2c 177 4 Article Article NNP cord-302115-r39ser2c 178 1 This this DT cord-302115-r39ser2c 178 2 article article NN cord-302115-r39ser2c 178 3 is be VBZ cord-302115-r39ser2c 178 4 protected protect VBN cord-302115-r39ser2c 178 5 by by IN cord-302115-r39ser2c 178 6 copyright copyright NN cord-302115-r39ser2c 178 7 . . . cord-302115-r39ser2c 179 1 All all DT cord-302115-r39ser2c 179 2 rights right NNS cord-302115-r39ser2c 179 3 reserved reserve VBD cord-302115-r39ser2c 179 4 83 83 CD cord-302115-r39ser2c 180 1 -Panda -Panda NNP cord-302115-r39ser2c 180 2 S S NNP cord-302115-r39ser2c 180 3 , , , cord-302115-r39ser2c 180 4 Ding Ding NNP cord-302115-r39ser2c 180 5 JL JL NNP cord-302115-r39ser2c 180 6 . . . cord-302115-r39ser2c 181 1 Natural natural JJ cord-302115-r39ser2c 181 2 antibodies antibody NNS cord-302115-r39ser2c 181 3 bridge bridge VBP cord-302115-r39ser2c 181 4 innate innate JJ cord-302115-r39ser2c 181 5 and and CC cord-302115-r39ser2c 181 6 adaptive adaptive JJ cord-302115-r39ser2c 181 7 immunity immunity NN cord-302115-r39ser2c 182 1 A a DT cord-302115-r39ser2c 182 2 study study NN cord-302115-r39ser2c 182 3 of of IN cord-302115-r39ser2c 182 4 serum serum NN cord-302115-r39ser2c 182 5 immunoglobulin immunoglobulin NN cord-302115-r39ser2c 182 6 levels level NNS cord-302115-r39ser2c 182 7 in in IN cord-302115-r39ser2c 182 8 elderly elderly JJ cord-302115-r39ser2c 182 9 persons person NNS cord-302115-r39ser2c 182 10 that that WDT cord-302115-r39ser2c 182 11 provides provide VBZ cord-302115-r39ser2c 182 12 new new JJ cord-302115-r39ser2c 182 13 insights insight NNS cord-302115-r39ser2c 182 14 into into IN cord-302115-r39ser2c 182 15 B b NN cord-302115-r39ser2c 182 16 cell cell NN cord-302115-r39ser2c 182 17 immunosenescence immunosenescence IN cord-302115-r39ser2c 182 18 Influence influence NN cord-302115-r39ser2c 182 19 of of IN cord-302115-r39ser2c 182 20 sex sex NN cord-302115-r39ser2c 182 21 and and CC cord-302115-r39ser2c 182 22 age age NN cord-302115-r39ser2c 182 23 on on IN cord-302115-r39ser2c 182 24 serum serum NN cord-302115-r39ser2c 182 25 immunoglobulin immunoglobulin NN cord-302115-r39ser2c 182 26 concentrations concentration NNS cord-302115-r39ser2c 182 27 in in IN cord-302115-r39ser2c 182 28 healthy healthy JJ cord-302115-r39ser2c 182 29 subjects subject NNS cord-302115-r39ser2c 182 30 89 89 CD cord-302115-r39ser2c 183 1 -Cooling -coole VBG cord-302115-r39ser2c 183 2 L. L. NNP cord-302115-r39ser2c 183 3 Blood Blood NNP cord-302115-r39ser2c 183 4 Groups Groups NNPS cord-302115-r39ser2c 183 5 in in IN cord-302115-r39ser2c 183 6 Infection Infection NNP cord-302115-r39ser2c 183 7 and and CC cord-302115-r39ser2c 183 8 Host Host NNP cord-302115-r39ser2c 183 9 Susceptibility Susceptibility NNP cord-302115-r39ser2c 183 10 ABO ABO NNP cord-302115-r39ser2c 183 11 Blood Blood NNP cord-302115-r39ser2c 183 12 Group Group NNP cord-302115-r39ser2c 183 13 and and CC cord-302115-r39ser2c 183 14 Susceptibility Susceptibility NNP cord-302115-r39ser2c 183 15 to to IN cord-302115-r39ser2c 183 16 Severe severe JJ cord-302115-r39ser2c 183 17 Acute acute JJ cord-302115-r39ser2c 183 18 Respiratory Respiratory NNP cord-302115-r39ser2c 183 19 Syndrome Syndrome NNP cord-302115-r39ser2c 183 20 Inhibition Inhibition NNP cord-302115-r39ser2c 183 21 of of IN cord-302115-r39ser2c 183 22 the the DT cord-302115-r39ser2c 183 23 interaction interaction NN cord-302115-r39ser2c 183 24 between between IN cord-302115-r39ser2c 183 25 the the DT cord-302115-r39ser2c 183 26 SARS SARS NNP cord-302115-r39ser2c 183 27 - - HYPH cord-302115-r39ser2c 183 28 CoV CoV NNP cord-302115-r39ser2c 183 29 spike spike NN cord-302115-r39ser2c 183 30 protein protein NN cord-302115-r39ser2c 183 31 and and CC cord-302115-r39ser2c 183 32 its -PRON- PRP$ cord-302115-r39ser2c 183 33 cellular cellular JJ cord-302115-r39ser2c 183 34 receptor receptor NN cord-302115-r39ser2c 183 35 by by IN cord-302115-r39ser2c 183 36 anti anti JJ cord-302115-r39ser2c 183 37 - - JJ cord-302115-r39ser2c 183 38 histoblood histoblood JJ cord-302115-r39ser2c 183 39 group group NN cord-302115-r39ser2c 183 40 antibodies antibody NNS cord-302115-r39ser2c 183 41 Human Human NNP cord-302115-r39ser2c 183 42 serum serum NN cord-302115-r39ser2c 183 43 mannose mannose NN cord-302115-r39ser2c 183 44 binding bind VBG cord-302115-r39ser2c 183 45 protein protein NN cord-302115-r39ser2c 183 46 ( ( -LRB- cord-302115-r39ser2c 183 47 MBP MBP NNP cord-302115-r39ser2c 183 48 ) ) -RRB- cord-302115-r39ser2c 184 1 : : : cord-302115-r39ser2c 184 2 development development NN cord-302115-r39ser2c 184 3 of of IN cord-302115-r39ser2c 184 4 an an DT cord-302115-r39ser2c 184 5 enzyme enzyme NN cord-302115-r39ser2c 184 6 - - HYPH cord-302115-r39ser2c 184 7 linked link VBN cord-302115-r39ser2c 184 8 immunosorbent immunosorbent JJ cord-302115-r39ser2c 184 9 assay assay NN cord-302115-r39ser2c 184 10 ( ( -LRB- cord-302115-r39ser2c 184 11 ELISA ELISA NNP cord-302115-r39ser2c 184 12 ) ) -RRB- cord-302115-r39ser2c 184 13 and and CC cord-302115-r39ser2c 184 14 determination determination NN cord-302115-r39ser2c 184 15 of of IN cord-302115-r39ser2c 184 16 levels level NNS cord-302115-r39ser2c 184 17 in in IN cord-302115-r39ser2c 184 18 serum serum NN cord-302115-r39ser2c 184 19 from from IN cord-302115-r39ser2c 184 20 1085 1085 CD cord-302115-r39ser2c 184 21 normal normal JJ cord-302115-r39ser2c 184 22 Japanese Japanese NNPS cord-302115-r39ser2c 184 23 and and CC cord-302115-r39ser2c 184 24 in in IN cord-302115-r39ser2c 184 25 some some DT cord-302115-r39ser2c 184 26 body body NN cord-302115-r39ser2c 184 27 fluids fluid VBZ cord-302115-r39ser2c 184 28 96 96 CD cord-302115-r39ser2c 185 1 -Terai -Terai . cord-302115-r39ser2c 186 1 I -PRON- PRP cord-302115-r39ser2c 186 2 , , , cord-302115-r39ser2c 186 3 Kobayashi Kobayashi NNP cord-302115-r39ser2c 186 4 K. K. NNP cord-302115-r39ser2c 186 5 Perinatal Perinatal NNP cord-302115-r39ser2c 186 6 changes change VBZ cord-302115-r39ser2c 186 7 in in IN cord-302115-r39ser2c 186 8 serum serum NN cord-302115-r39ser2c 186 9 mannose mannose NN cord-302115-r39ser2c 186 10 - - HYPH cord-302115-r39ser2c 186 11 binding bind VBG cord-302115-r39ser2c 186 12 protein protein NN cord-302115-r39ser2c 186 13 ( ( -LRB- cord-302115-r39ser2c 186 14 MBP)levels mbp)level NNS cord-302115-r39ser2c 187 1 Childhood childhood NN cord-302115-r39ser2c 187 2 levels level NNS cord-302115-r39ser2c 187 3 of of IN cord-302115-r39ser2c 187 4 immunoglobulins immunoglobulin NNS cord-302115-r39ser2c 187 5 and and CC cord-302115-r39ser2c 187 6 mannan mannan NN cord-302115-r39ser2c 187 7 - - HYPH cord-302115-r39ser2c 187 8 binding bind VBG cord-302115-r39ser2c 187 9 lectin lectin NN cord-302115-r39ser2c 187 10 in in IN cord-302115-r39ser2c 187 11 relation relation NN cord-302115-r39ser2c 187 12 to to IN cord-302115-r39ser2c 187 13 infections infection NNS cord-302115-r39ser2c 187 14 and and CC cord-302115-r39ser2c 187 15 allergy allergy NN cord-302115-r39ser2c 187 16 Functional functional JJ cord-302115-r39ser2c 187 17 polymorphisms polymorphism NNS cord-302115-r39ser2c 187 18 of of IN cord-302115-r39ser2c 187 19 the the DT cord-302115-r39ser2c 187 20 CCL2 CCL2 NNP cord-302115-r39ser2c 187 21 and and CC cord-302115-r39ser2c 187 22 MBL MBL NNP cord-302115-r39ser2c 187 23 genes gene NNS cord-302115-r39ser2c 187 24 cumulatively cumulatively RB cord-302115-r39ser2c 187 25 increase increase VBP cord-302115-r39ser2c 187 26 susceptibility susceptibility NN cord-302115-r39ser2c 187 27 to to IN cord-302115-r39ser2c 187 28 severe severe JJ cord-302115-r39ser2c 187 29 acute acute JJ cord-302115-r39ser2c 187 30 respiratory respiratory JJ cord-302115-r39ser2c 187 31 syndrome syndrome NN cord-302115-r39ser2c 187 32 coronavirus coronavirus NN cord-302115-r39ser2c 187 33 infection infection NN cord-302115-r39ser2c 188 1 A a DT cord-302115-r39ser2c 188 2 Single single JJ cord-302115-r39ser2c 188 3 Asparagine asparagine NN cord-302115-r39ser2c 188 4 - - HYPH cord-302115-r39ser2c 188 5 Linked link VBN cord-302115-r39ser2c 188 6 Glycosylation Glycosylation NNP cord-302115-r39ser2c 188 7 Site site NN cord-302115-r39ser2c 188 8 of of IN cord-302115-r39ser2c 188 9 the the DT cord-302115-r39ser2c 188 10 Severe severe JJ cord-302115-r39ser2c 188 11 Acute acute JJ cord-302115-r39ser2c 188 12 Respiratory Respiratory NNP cord-302115-r39ser2c 188 13 Syndrome Syndrome NNP cord-302115-r39ser2c 188 14 Coronavirus Coronavirus NNP cord-302115-r39ser2c 188 15 Spike Spike NNP cord-302115-r39ser2c 188 16 Glycoprotein Glycoprotein NNP cord-302115-r39ser2c 189 1 Accepted Accepted NNP cord-302115-r39ser2c 189 2 Article Article NNP cord-302115-r39ser2c 190 1 This this DT cord-302115-r39ser2c 190 2 article article NN cord-302115-r39ser2c 190 3 is be VBZ cord-302115-r39ser2c 190 4 protected protect VBN cord-302115-r39ser2c 190 5 by by IN cord-302115-r39ser2c 190 6 copyright copyright NN cord-302115-r39ser2c 190 7 . . . cord-302115-r39ser2c 191 1 All all DT cord-302115-r39ser2c 191 2 rights right NNS cord-302115-r39ser2c 191 3 reserved reserve VBN cord-302115-r39ser2c 191 4 Facilitates facilitate VBZ cord-302115-r39ser2c 191 5 Inhibition inhibition NN cord-302115-r39ser2c 191 6 by by IN cord-302115-r39ser2c 191 7 Mannose Mannose NNP cord-302115-r39ser2c 191 8 - - HYPH cord-302115-r39ser2c 191 9 Binding bind VBG cord-302115-r39ser2c 191 10 Lectin Lectin NNP cord-302115-r39ser2c 191 11 through through IN cord-302115-r39ser2c 191 12 Multiple Multiple NNP cord-302115-r39ser2c 191 13 Mechanisms Mechanisms NNPS cord-302115-r39ser2c 191 14 Highly highly RB cord-302115-r39ser2c 191 15 pathogenic pathogenic JJ cord-302115-r39ser2c 191 16 coronavirus coronavirus NN cord-302115-r39ser2c 191 17 N n CD cord-302115-r39ser2c 191 18 protein protein NN cord-302115-r39ser2c 191 19 aggravates aggravate VBZ cord-302115-r39ser2c 191 20 lung lung NN cord-302115-r39ser2c 191 21 injury injury NN cord-302115-r39ser2c 191 22 by by IN cord-302115-r39ser2c 191 23 MASP-2-mediated masp-2-mediate VBN cord-302115-r39ser2c 191 24 complement complement VB cord-302115-r39ser2c 191 25 over over IN cord-302115-r39ser2c 191 26 - - HYPH cord-302115-r39ser2c 191 27 activation activation NN cord-302115-r39ser2c 191 28 . . . cord-302115-r39ser2c 192 1 medRxiv medRxiv NNP cord-302115-r39ser2c 192 2 preprint preprint NN cord-302115-r39ser2c 192 3 2020 2020 CD cord-302115-r39ser2c 193 1 How how WRB cord-302115-r39ser2c 193 2 does do VBZ cord-302115-r39ser2c 193 3 COVID-19 covid-19 VB cord-302115-r39ser2c 193 4 kill kill VB cord-302115-r39ser2c 193 5 ? ? . cord-302115-r39ser2c 194 1 Uncertainty uncertainty NN cord-302115-r39ser2c 194 2 is be VBZ cord-302115-r39ser2c 194 3 hampering hamper VBG cord-302115-r39ser2c 194 4 doctors doctor NNS cord-302115-r39ser2c 194 5 ' ' POS cord-302115-r39ser2c 194 6 ability ability NN cord-302115-r39ser2c 194 7 to to TO cord-302115-r39ser2c 194 8 choose choose VB cord-302115-r39ser2c 194 9 treatments treatment NNS cord-302115-r39ser2c 194 10 Comparative comparative JJ cord-302115-r39ser2c 194 11 replication replication NN cord-302115-r39ser2c 194 12 and and CC cord-302115-r39ser2c 194 13 immune immune JJ cord-302115-r39ser2c 194 14 activation activation NN cord-302115-r39ser2c 194 15 profiles profile NNS cord-302115-r39ser2c 194 16 of of IN cord-302115-r39ser2c 194 17 SARS SARS NNP cord-302115-r39ser2c 194 18 - - HYPH cord-302115-r39ser2c 194 19 CoV-2 CoV-2 NNP cord-302115-r39ser2c 194 20 and and CC cord-302115-r39ser2c 194 21 SARS SARS NNP cord-302115-r39ser2c 194 22 - - HYPH cord-302115-r39ser2c 194 23 CoV CoV NNP cord-302115-r39ser2c 194 24 in in IN cord-302115-r39ser2c 194 25 human human JJ cord-302115-r39ser2c 194 26 lungs lung NNS cord-302115-r39ser2c 194 27 : : : cord-302115-r39ser2c 194 28 an an DT cord-302115-r39ser2c 194 29 ex ex FW cord-302115-r39ser2c 194 30 vivo vivo NN cord-302115-r39ser2c 194 31 study study NN cord-302115-r39ser2c 194 32 with with IN cord-302115-r39ser2c 194 33 implications implication NNS cord-302115-r39ser2c 194 34 for for IN cord-302115-r39ser2c 194 35 the the DT cord-302115-r39ser2c 194 36 pathogenesis pathogenesis NN cord-302115-r39ser2c 194 37 of of IN cord-302115-r39ser2c 194 38 COVID-19 COVID-19 NNP cord-302115-r39ser2c 194 39 Level Level NNP cord-302115-r39ser2c 194 40 of of IN cord-302115-r39ser2c 194 41 IL-6 IL-6 NNP cord-302115-r39ser2c 194 42 predicts predict VBZ cord-302115-r39ser2c 194 43 respiratory respiratory JJ cord-302115-r39ser2c 194 44 failure failure NN cord-302115-r39ser2c 194 45 in in IN cord-302115-r39ser2c 194 46 hospitalized hospitalize VBN cord-302115-r39ser2c 194 47 symptomatic symptomatic JJ cord-302115-r39ser2c 194 48 COVID-19 covid-19 CD cord-302115-r39ser2c 194 49 patients patient NNS cord-302115-r39ser2c 194 50 Off off IN cord-302115-r39ser2c 194 51 - - HYPH cord-302115-r39ser2c 194 52 label label NN cord-302115-r39ser2c 194 53 Use use NN cord-302115-r39ser2c 194 54 of of IN cord-302115-r39ser2c 194 55 Tocilizumab Tocilizumab NNP cord-302115-r39ser2c 194 56 in in IN cord-302115-r39ser2c 194 57 Patients patient NNS cord-302115-r39ser2c 194 58 with with IN cord-302115-r39ser2c 194 59 SARS SARS NNP cord-302115-r39ser2c 194 60 - - HYPH cord-302115-r39ser2c 194 61 CoV-2 CoV-2 NNP cord-302115-r39ser2c 194 62 Infection Infection NNP cord-302115-r39ser2c 194 63 Pathological pathological JJ cord-302115-r39ser2c 194 64 study study NN cord-302115-r39ser2c 194 65 of of IN cord-302115-r39ser2c 194 66 the the DT cord-302115-r39ser2c 194 67 2019 2019 CD cord-302115-r39ser2c 194 68 novel novel JJ cord-302115-r39ser2c 194 69 coronavirus coronavirus NN cord-302115-r39ser2c 194 70 disease disease NN cord-302115-r39ser2c 194 71 ( ( -LRB- cord-302115-r39ser2c 194 72 COVID-19 covid-19 VB cord-302115-r39ser2c 194 73 ) ) -RRB- cord-302115-r39ser2c 194 74 through through IN cord-302115-r39ser2c 194 75 postmortem postmortem JJ cord-302115-r39ser2c 194 76 core core NN cord-302115-r39ser2c 194 77 biopsies biopsy NNS cord-302115-r39ser2c 195 1 Abnormal abnormal JJ cord-302115-r39ser2c 195 2 coagulation coagulation NN cord-302115-r39ser2c 195 3 parameters parameter NNS cord-302115-r39ser2c 195 4 are be VBP cord-302115-r39ser2c 195 5 associated associate VBN cord-302115-r39ser2c 195 6 with with IN cord-302115-r39ser2c 195 7 poor poor JJ cord-302115-r39ser2c 195 8 prognosis prognosis NN cord-302115-r39ser2c 195 9 in in IN cord-302115-r39ser2c 195 10 patients patient NNS cord-302115-r39ser2c 195 11 with with IN cord-302115-r39ser2c 195 12 novel novel JJ cord-302115-r39ser2c 195 13 coronavirus coronavirus NN cord-302115-r39ser2c 195 14 pneumonia pneumonia NN cord-302115-r39ser2c 195 15 Accepted Accepted NNP cord-302115-r39ser2c 195 16 Article Article NNP cord-302115-r39ser2c 195 17 thrombomodulin thrombomodulin NNP cord-302115-r39ser2c 195 18 is be VBZ cord-302115-r39ser2c 195 19 associated associate VBN cord-302115-r39ser2c 195 20 with with IN cord-302115-r39ser2c 195 21 organ organ NN cord-302115-r39ser2c 195 22 failure failure NN cord-302115-r39ser2c 195 23 and and CC cord-302115-r39ser2c 195 24 mortality mortality NN cord-302115-r39ser2c 195 25 in in IN cord-302115-r39ser2c 195 26 children child NNS cord-302115-r39ser2c 195 27 with with IN cord-302115-r39ser2c 195 28 acute acute JJ cord-302115-r39ser2c 195 29 respiratory respiratory JJ cord-302115-r39ser2c 195 30 distress distress NN cord-302115-r39ser2c 195 31 syndrome syndrome NN cord-302115-r39ser2c 195 32 ( ( -LRB- cord-302115-r39ser2c 195 33 ARDS ARDS NNP cord-302115-r39ser2c 195 34 ) ) -RRB- cord-302115-r39ser2c 195 35 : : : cord-302115-r39ser2c 195 36 a a DT cord-302115-r39ser2c 195 37 prospective prospective JJ cord-302115-r39ser2c 195 38 observational observational JJ cord-302115-r39ser2c 195 39 cohort cohort NN cord-302115-r39ser2c 195 40 study study NN cord-302115-r39ser2c 195 41 Analytical analytical JJ cord-302115-r39ser2c 195 42 performances performance NNS cord-302115-r39ser2c 195 43 of of IN cord-302115-r39ser2c 195 44 a a DT cord-302115-r39ser2c 195 45 chemiluminescence chemiluminescence NN cord-302115-r39ser2c 195 46 immunoassay immunoassay NN cord-302115-r39ser2c 195 47 for for IN cord-302115-r39ser2c 195 48 SARS SARS NNP cord-302115-r39ser2c 195 49 - - HYPH cord-302115-r39ser2c 195 50 CoV-2 CoV-2 NNP cord-302115-r39ser2c 195 51 IgM IgM NNP cord-302115-r39ser2c 195 52 / / SYM cord-302115-r39ser2c 195 53 IgG IgG NNP cord-302115-r39ser2c 195 54 and and CC cord-302115-r39ser2c 195 55 antibody antibody NN cord-302115-r39ser2c 195 56 kinetics kinetics NNP cord-302115-r39ser2c 195 57 Microvascular Microvascular NNP cord-302115-r39ser2c 195 58 COVID-19 covid-19 POS cord-302115-r39ser2c 195 59 lung lung NN cord-302115-r39ser2c 195 60 vessels vessel NNS cord-302115-r39ser2c 196 1 obstructive obstructive JJ cord-302115-r39ser2c 196 2 thromboinflammatory thromboinflammatory NNP cord-302115-r39ser2c 196 3 syndrome syndrome NN cord-302115-r39ser2c 196 4 ( ( -LRB- cord-302115-r39ser2c 196 5 MicroCLOTS MicroCLOTS NNP cord-302115-r39ser2c 196 6 ) ) -RRB- cord-302115-r39ser2c 196 7 : : : cord-302115-r39ser2c 197 1 an an DT cord-302115-r39ser2c 197 2 atypical atypical JJ cord-302115-r39ser2c 197 3 acute acute JJ cord-302115-r39ser2c 197 4 respiratory respiratory JJ cord-302115-r39ser2c 197 5 distress distress NN cord-302115-r39ser2c 197 6 syndrome syndrome NN cord-302115-r39ser2c 197 7 working work VBG cord-302115-r39ser2c 197 8 hypothesis hypothesis NN cord-302115-r39ser2c 197 9 Unexpected unexpected JJ cord-302115-r39ser2c 197 10 receptor receptor NN cord-302115-r39ser2c 197 11 functional functional JJ cord-302115-r39ser2c 197 12 mimicry mimicry NN cord-302115-r39ser2c 197 13 elucidates elucidate VBZ cord-302115-r39ser2c 197 14 activation activation NN cord-302115-r39ser2c 197 15 of of IN cord-302115-r39ser2c 197 16 coronavirus coronavirus NN cord-302115-r39ser2c 197 17 fusion fusion NN cord-302115-r39ser2c 197 18 Accepted accept VBN cord-302115-r39ser2c 197 19 Article Article NNP cord-302115-r39ser2c 198 1 The the DT cord-302115-r39ser2c 198 2 text text NN cord-302115-r39ser2c 198 3 contains contain VBZ cord-302115-r39ser2c 198 4 the the DT cord-302115-r39ser2c 198 5 personal personal JJ cord-302115-r39ser2c 198 6 opinion opinion NN cord-302115-r39ser2c 198 7 of of IN cord-302115-r39ser2c 198 8 the the DT cord-302115-r39ser2c 198 9 Authors author NNS cord-302115-r39ser2c 198 10 , , , cord-302115-r39ser2c 198 11 not not RB cord-302115-r39ser2c 198 12 of of IN cord-302115-r39ser2c 198 13 their -PRON- PRP$ cord-302115-r39ser2c 198 14 Institutions institution NNS cord-302115-r39ser2c 198 15 : : : cord-302115-r39ser2c 198 16 Charité Charité NNP cord-302115-r39ser2c 198 17 Universitaetsmedizin Universitaetsmedizin NNP cord-302115-r39ser2c 198 18 Berlin Berlin NNP cord-302115-r39ser2c 198 19 , , , cord-302115-r39ser2c 198 20 Germany Germany NNP cord-302115-r39ser2c 198 21 ( ( -LRB- cord-302115-r39ser2c 198 22 PMM PMM NNP cord-302115-r39ser2c 198 23 ) ) -RRB- cord-302115-r39ser2c 198 24 and and CC cord-302115-r39ser2c 198 25 Istituto Istituto NNP cord-302115-r39ser2c 198 26 Superiore Superiore NNP cord-302115-r39ser2c 198 27 di di NNP cord-302115-r39ser2c 198 28 Sanità Sanità NNP cord-302115-r39ser2c 198 29 , , , cord-302115-r39ser2c 198 30 Rome Rome NNP cord-302115-r39ser2c 198 31 , , , cord-302115-r39ser2c 198 32 Italy Italy NNP cord-302115-r39ser2c 199 1 ( ( -LRB- cord-302115-r39ser2c 199 2 RN).All RN).All `` cord-302115-r39ser2c 199 3 authors author NNS cord-302115-r39ser2c 199 4 declare declare VBP cord-302115-r39ser2c 199 5 no no DT cord-302115-r39ser2c 199 6 conflict conflict NN cord-302115-r39ser2c 199 7 of of IN cord-302115-r39ser2c 199 8 interest interest NN cord-302115-r39ser2c 199 9 . . .