id	sid	tid	token	lemma	pos
cord-300805-apli48ih	1	1	key	key	NN
cord-300805-apli48ih	1	2	:	:	:
cord-300805-apli48ih	1	3	cord-300805-apli48ih	cord-300805-apli48ih	JJR
cord-300805-apli48ih	1	4	authors	author	NNS
cord-300805-apli48ih	1	5	:	:	:
cord-300805-apli48ih	1	6	Augoustides	Augoustides	NNP
cord-300805-apli48ih	1	7	,	,	,
cord-300805-apli48ih	1	8	John	John	NNP
cord-300805-apli48ih	1	9	G.	G.	NNP
cord-300805-apli48ih	1	10	title	title	NN
cord-300805-apli48ih	1	11	:	:	:
cord-300805-apli48ih	2	1	The	the	DT
cord-300805-apli48ih	2	2	Renin	Renin	NNP
cord-300805-apli48ih	2	3	-	-	HYPH
cord-300805-apli48ih	2	4	Angiotensin	Angiotensin	NNP
cord-300805-apli48ih	2	5	-	-	HYPH
cord-300805-apli48ih	2	6	Aldosterone	Aldosterone	NNP
cord-300805-apli48ih	2	7	System	System	NNP
cord-300805-apli48ih	2	8	in	in	IN
cord-300805-apli48ih	2	9	Coronavirus	Coronavirus	NNP
cord-300805-apli48ih	2	10	Infection	infection	NN
cord-300805-apli48ih	2	11	–	–	:
cord-300805-apli48ih	2	12	current	current	JJ
cord-300805-apli48ih	2	13	considerations	consideration	NNS
cord-300805-apli48ih	2	14	during	during	IN
cord-300805-apli48ih	2	15	the	the	DT
cord-300805-apli48ih	2	16	pandemic	pandemic	NN
cord-300805-apli48ih	2	17	date	date	NN
cord-300805-apli48ih	2	18	:	:	:
cord-300805-apli48ih	2	19	2020	2020	CD
cord-300805-apli48ih	2	20	-	-	HYPH
cord-300805-apli48ih	2	21	04	04	CD
cord-300805-apli48ih	2	22	-	-	HYPH
cord-300805-apli48ih	2	23	16	16	CD
cord-300805-apli48ih	2	24	journal	journal	NN
cord-300805-apli48ih	2	25	:	:	:
cord-300805-apli48ih	3	1	J	J	NNP
cord-300805-apli48ih	3	2	Cardiothorac	Cardiothorac	NNP
cord-300805-apli48ih	3	3	Vasc	Vasc	NNP
cord-300805-apli48ih	4	1	Anesth	Anesth	NNP
cord-300805-apli48ih	4	2	DOI	DOI	NNP
cord-300805-apli48ih	4	3	:	:	:
cord-300805-apli48ih	5	1	10.1053/	10.1053/	CD
cord-300805-apli48ih	6	1	j.jvca.2020.04.010	j.jvca.2020.04.010	XX
cord-300805-apli48ih	7	1	sha	sha	NNP
cord-300805-apli48ih	7	2	:	:	:
cord-300805-apli48ih	8	1	638913cbcd37530b1122400714a25cc3336cd19e	638913cbcd37530b1122400714a25cc3336cd19e	NNP
cord-300805-apli48ih	8	2	doc_id	doc_id	CD
cord-300805-apli48ih	8	3	:	:	:
cord-300805-apli48ih	8	4	300805	300805	CD
cord-300805-apli48ih	8	5	cord_uid	cord_uid	NNS
cord-300805-apli48ih	8	6	:	:	:
cord-300805-apli48ih	9	1	apli48ih	apli48ih	NNP
cord-300805-apli48ih	9	2	nan	nan	NNP
cord-300805-apli48ih	10	1	The	the	DT
cord-300805-apli48ih	10	2	renin	renin	NN
cord-300805-apli48ih	10	3	-	-	HYPH
cord-300805-apli48ih	10	4	angiotensin	angiotensin	NN
cord-300805-apli48ih	10	5	-	-	HYPH
cord-300805-apli48ih	10	6	aldosterone	aldosterone	NN
cord-300805-apli48ih	10	7	system	system	NN
cord-300805-apli48ih	10	8	(	(	-LRB-
cord-300805-apli48ih	10	9	RAAS	RAAS	NNP
cord-300805-apli48ih	10	10	)	)	-RRB-
cord-300805-apli48ih	10	11	is	be	VBZ
cord-300805-apli48ih	10	12	a	a	DT
cord-300805-apli48ih	10	13	complex	complex	JJ
cord-300805-apli48ih	10	14	peptide	peptide	NN
cord-300805-apli48ih	10	15	cascade	cascade	NN
cord-300805-apli48ih	10	16	that	that	WDT
cord-300805-apli48ih	10	17	has	have	VBZ
cord-300805-apli48ih	10	18	a	a	DT
cord-300805-apli48ih	10	19	prominent	prominent	JJ
cord-300805-apli48ih	10	20	role	role	NN
cord-300805-apli48ih	10	21	in	in	IN
cord-300805-apli48ih	10	22	multiple	multiple	JJ
cord-300805-apli48ih	10	23	important	important	JJ
cord-300805-apli48ih	10	24	physiological	physiological	JJ
cord-300805-apli48ih	10	25	processes	process	NNS
cord-300805-apli48ih	10	26	such	such	JJ
cord-300805-apli48ih	10	27	as	as	IN
cord-300805-apli48ih	10	28	vascular	vascular	JJ
cord-300805-apli48ih	10	29	tone	tone	NN
cord-300805-apli48ih	10	30	,	,	,
cord-300805-apli48ih	10	31	vascular	vascular	JJ
cord-300805-apli48ih	10	32	permeability	permeability	NN
cord-300805-apli48ih	10	33	,	,	,
cord-300805-apli48ih	10	34	and	and	CC
cord-300805-apli48ih	10	35	myocardial	myocardial	JJ
cord-300805-apli48ih	10	36	remodeling	remodeling	NN
cord-300805-apli48ih	10	37	.	.	.
cord-300805-apli48ih	11	1	[	[	-LRB-
cord-300805-apli48ih	11	2	1	1	CD
cord-300805-apli48ih	11	3	]	]	-RRB-
cord-300805-apli48ih	11	4	[	[	-LRB-
cord-300805-apli48ih	11	5	2	2	CD
cord-300805-apli48ih	11	6	]	]	-RRB-
cord-300805-apli48ih	11	7	[	[	-LRB-
cord-300805-apli48ih	11	8	3	3	CD
cord-300805-apli48ih	11	9	]	]	-RRB-
cord-300805-apli48ih	11	10	The	the	DT
cord-300805-apli48ih	11	11	pharmacologic	pharmacologic	JJ
cord-300805-apli48ih	11	12	modulation	modulation	NN
cord-300805-apli48ih	11	13	of	of	IN
cord-300805-apli48ih	11	14	this	this	DT
cord-300805-apli48ih	11	15	system	system	NN
cord-300805-apli48ih	11	16	with	with	IN
cord-300805-apli48ih	11	17	agents	agent	NNS
cord-300805-apli48ih	11	18	such	such	JJ
cord-300805-apli48ih	11	19	as	as	IN
cord-300805-apli48ih	11	20	angiotensin	angiotensin	NN
cord-300805-apli48ih	11	21	-	-	HYPH
cord-300805-apli48ih	11	22	converting	convert	VBG
cord-300805-apli48ih	11	23	enzyme	enzyme	NN
cord-300805-apli48ih	11	24	inhibitors	inhibitor	NNS
cord-300805-apli48ih	11	25	(	(	-LRB-
cord-300805-apli48ih	11	26	ACEI	ACEI	NNP
cord-300805-apli48ih	11	27	)	)	-RRB-
cord-300805-apli48ih	11	28	and	and	CC
cord-300805-apli48ih	11	29	angiotensin	angiotensin	NN
cord-300805-apli48ih	11	30	receptor	receptor	NN
cord-300805-apli48ih	11	31	blockers	blocker	NNS
cord-300805-apli48ih	11	32	(	(	-LRB-
cord-300805-apli48ih	11	33	ARBS	ARBS	NNP
cord-300805-apli48ih	11	34	)	)	-RRB-
cord-300805-apli48ih	11	35	has	have	VBZ
cord-300805-apli48ih	11	36	resulted	result	VBN
cord-300805-apli48ih	11	37	in	in	IN
cord-300805-apli48ih	11	38	major	major	JJ
cord-300805-apli48ih	11	39	clinical	clinical	JJ
cord-300805-apli48ih	11	40	benefits	benefit	NNS
cord-300805-apli48ih	11	41	in	in	IN
cord-300805-apli48ih	11	42	the	the	DT
cord-300805-apli48ih	11	43	medical	medical	JJ
cord-300805-apli48ih	11	44	management	management	NN
cord-300805-apli48ih	11	45	of	of	IN
cord-300805-apli48ih	11	46	hypertension	hypertension	NN
cord-300805-apli48ih	11	47	and	and	CC
cord-300805-apli48ih	11	48	heart	heart	NN
cord-300805-apli48ih	11	49	failure	failure	NN
cord-300805-apli48ih	11	50	.	.	.
cord-300805-apli48ih	12	1	3	3	LS
cord-300805-apli48ih	13	1	Furthermore	furthermore	RB
cord-300805-apli48ih	13	2	,	,	,
cord-300805-apli48ih	13	3	the	the	DT
cord-300805-apli48ih	13	4	consequences	consequence	NNS
cord-300805-apli48ih	13	5	of	of	IN
cord-300805-apli48ih	13	6	this	this	DT
cord-300805-apli48ih	13	7	pharmacologic	pharmacologic	JJ
cord-300805-apli48ih	13	8	blockade	blockade	NN
cord-300805-apli48ih	13	9	of	of	IN
cord-300805-apli48ih	13	10	the	the	DT
cord-300805-apli48ih	13	11	RAAS	raa	NNS
cord-300805-apli48ih	13	12	in	in	IN
cord-300805-apli48ih	13	13	perioperative	perioperative	JJ
cord-300805-apli48ih	13	14	cardiothoracic	cardiothoracic	JJ
cord-300805-apli48ih	13	15	and	and	CC
cord-300805-apli48ih	13	16	vascular	vascular	JJ
cord-300805-apli48ih	13	17	practice	practice	NN
cord-300805-apli48ih	13	18	has	have	VBZ
cord-300805-apli48ih	13	19	been	be	VBN
cord-300805-apli48ih	13	20	well	well	RB
cord-300805-apli48ih	13	21	-	-	HYPH
cord-300805-apli48ih	13	22	recognized	recognize	VBN
cord-300805-apli48ih	13	23	,	,	,
cord-300805-apli48ih	13	24	leading	lead	VBG
cord-300805-apli48ih	13	25	to	to	IN
cord-300805-apli48ih	13	26	the	the	DT
cord-300805-apli48ih	13	27	emergence	emergence	NN
cord-300805-apli48ih	13	28	of	of	IN
cord-300805-apli48ih	13	29	rescue	rescue	NN
cord-300805-apli48ih	13	30	therapies	therapy	NNS
cord-300805-apli48ih	13	31	for	for	IN
cord-300805-apli48ih	13	32	support	support	NN
cord-300805-apli48ih	13	33	of	of	IN
cord-300805-apli48ih	13	34	vascular	vascular	JJ
cord-300805-apli48ih	13	35	tone	tone	NN
cord-300805-apli48ih	13	36	.	.	.
cord-300805-apli48ih	14	1	[	[	-LRB-
cord-300805-apli48ih	14	2	4	4	CD
cord-300805-apli48ih	14	3	]	]	-RRB-
cord-300805-apli48ih	14	4	[	[	-LRB-
cord-300805-apli48ih	14	5	5	5	CD
cord-300805-apli48ih	14	6	]	]	-RRB-
cord-300805-apli48ih	15	1	The	the	DT
cord-300805-apli48ih	15	2	severe	severe	JJ
cord-300805-apli48ih	15	3	acute	acute	JJ
cord-300805-apli48ih	15	4	respiratory	respiratory	JJ
cord-300805-apli48ih	15	5	syndrome	syndrome	NN
cord-300805-apli48ih	15	6	coronavirus-2	coronavirus-2	NN
cord-300805-apli48ih	15	7	infects	infect	VBZ
cord-300805-apli48ih	15	8	human	human	JJ
cord-300805-apli48ih	15	9	cells	cell	NNS
cord-300805-apli48ih	15	10	such	such	JJ
cord-300805-apli48ih	15	11	as	as	IN
cord-300805-apli48ih	15	12	alveolar	alveolar	JJ
cord-300805-apli48ih	15	13	endothelium	endothelium	NN
cord-300805-apli48ih	15	14	in	in	IN
cord-300805-apli48ih	15	15	the	the	DT
cord-300805-apli48ih	15	16	lung	lung	NN
cord-300805-apli48ih	15	17	by	by	IN
cord-300805-apli48ih	15	18	binding	bind	VBG
cord-300805-apli48ih	15	19	to	to	IN
cord-300805-apli48ih	15	20	the	the	DT
cord-300805-apli48ih	15	21	membrane	membrane	NN
cord-300805-apli48ih	15	22	receptor	receptor	NN
cord-300805-apli48ih	15	23	,	,	,
cord-300805-apli48ih	15	24	angiotensin	angiotensin	NN
cord-300805-apli48ih	15	25	-	-	HYPH
cord-300805-apli48ih	15	26	converting	convert	VBG
cord-300805-apli48ih	15	27	enzyme	enzyme	NN
cord-300805-apli48ih	15	28	2	2	CD
cord-300805-apli48ih	15	29	(	(	-LRB-
cord-300805-apli48ih	15	30	ACE2	ACE2	NNP
cord-300805-apli48ih	15	31	)	)	-RRB-
cord-300805-apli48ih	15	32	.	.	.
cord-300805-apli48ih	16	1	[	[	-LRB-
cord-300805-apli48ih	16	2	1	1	CD
cord-300805-apli48ih	16	3	]	]	-RRB-
cord-300805-apli48ih	16	4	[	[	-LRB-
cord-300805-apli48ih	16	5	2	2	CD
cord-300805-apli48ih	16	6	]	]	-RRB-
cord-300805-apli48ih	16	7	[	[	-LRB-
cord-300805-apli48ih	16	8	3	3	CD
cord-300805-apli48ih	16	9	]	]	-RRB-
cord-300805-apli48ih	17	1	Although	although	IN
cord-300805-apli48ih	17	2	the	the	DT
cord-300805-apli48ih	17	3	physiologic	physiologic	JJ
cord-300805-apli48ih	17	4	functions	function	NNS
cord-300805-apli48ih	17	5	of	of	IN
cord-300805-apli48ih	17	6	ACE2	ACE2	NNP
cord-300805-apli48ih	17	7	include	include	VBP
cord-300805-apli48ih	17	8	counteracting	counteract	VBG
cord-300805-apli48ih	17	9	the	the	DT
cord-300805-apli48ih	17	10	effects	effect	NNS
cord-300805-apli48ih	17	11	of	of	IN
cord-300805-apli48ih	17	12	RAAS	RAAS	NNP
cord-300805-apli48ih	17	13	activation	activation	NN
cord-300805-apli48ih	17	14	,	,	,
cord-300805-apli48ih	17	15	it	-PRON-	PRP
cord-300805-apli48ih	17	16	also	also	RB
cord-300805-apli48ih	17	17	functions	function	VBZ
cord-300805-apli48ih	17	18	as	as	IN
cord-300805-apli48ih	17	19	a	a	DT
cord-300805-apli48ih	17	20	membrane	membrane	NN
cord-300805-apli48ih	17	21	receptor	receptor	NN
cord-300805-apli48ih	17	22	for	for	IN
cord-300805-apli48ih	17	23	the	the	DT
cord-300805-apli48ih	17	24	coronavirus	coronavirus	NN
cord-300805-apli48ih	17	25	.	.	.
cord-300805-apli48ih	18	1	[	[	-LRB-
cord-300805-apli48ih	18	2	1	1	CD
cord-300805-apli48ih	18	3	]	]	-RRB-
cord-300805-apli48ih	18	4	[	[	-LRB-
cord-300805-apli48ih	18	5	2	2	CD
cord-300805-apli48ih	18	6	]	]	-RRB-
cord-300805-apli48ih	18	7	[	[	-LRB-
cord-300805-apli48ih	18	8	3	3	CD
cord-300805-apli48ih	18	9	]	]	-RRB-
cord-300805-apli48ih	19	1	This	this	DT
cord-300805-apli48ih	19	2	binding	bind	VBG
cord-300805-apli48ih	19	3	results	result	NNS
cord-300805-apli48ih	19	4	in	in	IN
cord-300805-apli48ih	19	5	endocytosis	endocytosis	NN
cord-300805-apli48ih	19	6	of	of	IN
cord-300805-apli48ih	19	7	the	the	DT
cord-300805-apli48ih	19	8	viral	viral	JJ
cord-300805-apli48ih	19	9	complex	complex	NN
cord-300805-apli48ih	19	10	with	with	IN
cord-300805-apli48ih	19	11	consequent	consequent	JJ
cord-300805-apli48ih	19	12	local	local	JJ
cord-300805-apli48ih	19	13	activation	activation	NN
cord-300805-apli48ih	19	14	of	of	IN
cord-300805-apli48ih	19	15	the	the	DT
cord-300805-apli48ih	19	16	RAAS	raa	NNS
cord-300805-apli48ih	19	17	,	,	,
cord-300805-apli48ih	19	18	resulting	result	VBG
cord-300805-apli48ih	19	19	in	in	IN
cord-300805-apli48ih	19	20	acute	acute	JJ
cord-300805-apli48ih	19	21	lung	lung	NN
cord-300805-apli48ih	19	22	injury	injury	NN
cord-300805-apli48ih	19	23	that	that	WDT
cord-300805-apli48ih	19	24	may	may	MD
cord-300805-apli48ih	19	25	progress	progress	VB
cord-300805-apli48ih	19	26	to	to	IN
cord-300805-apli48ih	19	27	adult	adult	JJ
cord-300805-apli48ih	19	28	respiratory	respiratory	JJ
cord-300805-apli48ih	19	29	distress	distress	NN
cord-300805-apli48ih	19	30	syndrome	syndrome	NN
cord-300805-apli48ih	19	31	.	.	.
cord-300805-apli48ih	20	1	1	1	LS
cord-300805-apli48ih	20	2	-	-	SYM
cord-300805-apli48ih	20	3	2	2	CD
cord-300805-apli48ih	20	4	;	;	:
cord-300805-apli48ih	20	5	6	6	CD
cord-300805-apli48ih	20	6	-	-	SYM
cord-300805-apli48ih	20	7	7	7	CD
cord-300805-apli48ih	20	8	The	the	DT
cord-300805-apli48ih	20	9	purpose	purpose	NN
cord-300805-apli48ih	20	10	of	of	IN
cord-300805-apli48ih	20	11	this	this	DT
cord-300805-apli48ih	20	12	freestanding	freestanding	JJ
cord-300805-apli48ih	20	13	editorial	editorial	NN
cord-300805-apli48ih	20	14	is	be	VBZ
cord-300805-apli48ih	20	15	to	to	TO
cord-300805-apli48ih	20	16	highlight	highlight	VB
cord-300805-apli48ih	20	17	the	the	DT
cord-300805-apli48ih	20	18	considerations	consideration	NNS
cord-300805-apli48ih	20	19	concerning	concern	VBG
cord-300805-apli48ih	20	20	the	the	DT
cord-300805-apli48ih	20	21	RAAS	raa	NNS
cord-300805-apli48ih	20	22	in	in	IN
cord-300805-apli48ih	20	23	patients	patient	NNS
cord-300805-apli48ih	20	24	presenting	present	VBG
cord-300805-apli48ih	20	25	with	with	IN
cord-300805-apli48ih	20	26	severe	severe	JJ
cord-300805-apli48ih	20	27	coronavirus	coronavirus	NN
cord-300805-apli48ih	20	28	disease	disease	NN
cord-300805-apli48ih	20	29	2019	2019	CD
cord-300805-apli48ih	20	30	.	.	.
cord-300805-apli48ih	21	1	This	this	DT
cord-300805-apli48ih	21	2	perspective	perspective	NN
cord-300805-apli48ih	21	3	will	will	MD
cord-300805-apli48ih	21	4	focus	focus	VB
cord-300805-apli48ih	21	5	on	on	IN
cord-300805-apli48ih	21	6	the	the	DT
cord-300805-apli48ih	21	7	clinical	clinical	JJ
cord-300805-apli48ih	21	8	relevance	relevance	NN
cord-300805-apli48ih	21	9	of	of	IN
cord-300805-apli48ih	21	10	these	these	DT
cord-300805-apli48ih	21	11	considerations	consideration	NNS
cord-300805-apli48ih	21	12	to	to	TO
cord-300805-apli48ih	21	13	inform	inform	VB
cord-300805-apli48ih	21	14	the	the	DT
cord-300805-apli48ih	21	15	management	management	NN
cord-300805-apli48ih	21	16	of	of	IN
cord-300805-apli48ih	21	17	these	these	DT
cord-300805-apli48ih	21	18	challenging	challenging	JJ
cord-300805-apli48ih	21	19	patients	patient	NNS
cord-300805-apli48ih	21	20	.	.	.
cord-300805-apli48ih	22	1	[	[	-LRB-
cord-300805-apli48ih	22	2	8	8	CD
cord-300805-apli48ih	22	3	]	]	-RRB-
cord-300805-apli48ih	22	4	[	[	-LRB-
cord-300805-apli48ih	22	5	9	9	CD
cord-300805-apli48ih	22	6	]	]	-RRB-
cord-300805-apli48ih	22	7	[	[	-LRB-
cord-300805-apli48ih	22	8	10	10	CD
cord-300805-apli48ih	22	9	]	]	-RRB-
cord-300805-apli48ih	23	1	[	[	-LRB-
cord-300805-apli48ih	23	2	11	11	CD
cord-300805-apli48ih	23	3	]	]	-RRB-
cord-300805-apli48ih	24	1	The	the	DT
cord-300805-apli48ih	24	2	references	reference	NNS
cord-300805-apli48ih	24	3	provide	provide	VBP
cord-300805-apli48ih	24	4	further	further	JJ
cord-300805-apli48ih	24	5	detail	detail	NN
cord-300805-apli48ih	24	6	for	for	IN
cord-300805-apli48ih	24	7	healthcare	healthcare	NN
cord-300805-apli48ih	24	8	teams	team	NNS
cord-300805-apli48ih	24	9	as	as	IN
cord-300805-apli48ih	24	10	they	-PRON-	PRP
cord-300805-apli48ih	24	11	manage	manage	VBP
cord-300805-apli48ih	24	12	the	the	DT
cord-300805-apli48ih	24	13	demands	demand	NNS
cord-300805-apli48ih	24	14	of	of	IN
cord-300805-apli48ih	24	15	the	the	DT
cord-300805-apli48ih	24	16	pandemic	pandemic	NN
cord-300805-apli48ih	24	17	at	at	IN
cord-300805-apli48ih	24	18	their	-PRON-	PRP$
cord-300805-apli48ih	24	19	respective	respective	JJ
cord-300805-apli48ih	24	20	institutions	institution	NNS
cord-300805-apli48ih	24	21	.	.	.
cord-300805-apli48ih	25	1	3	3	LS
cord-300805-apli48ih	26	1	The	the	DT
cord-300805-apli48ih	26	2	prevalence	prevalence	NN
cord-300805-apli48ih	26	3	of	of	IN
cord-300805-apli48ih	26	4	coexisting	coexist	VBG
cord-300805-apli48ih	26	5	hypertension	hypertension	NN
cord-300805-apli48ih	26	6	has	have	VBZ
cord-300805-apli48ih	26	7	been	be	VBN
cord-300805-apli48ih	26	8	estimated	estimate	VBN
cord-300805-apli48ih	26	9	to	to	TO
cord-300805-apli48ih	26	10	be	be	VB
cord-300805-apli48ih	26	11	in	in	IN
cord-300805-apli48ih	26	12	the	the	DT
cord-300805-apli48ih	26	13	(	(	-LRB-
cord-300805-apli48ih	26	14	10	10	CD
cord-300805-apli48ih	26	15	-	-	SYM
cord-300805-apli48ih	26	16	25)%	25)%	CD
cord-300805-apli48ih	26	17	range	range	NN
cord-300805-apli48ih	26	18	amongst	amongst	IN
cord-300805-apli48ih	26	19	patients	patient	NNS
cord-300805-apli48ih	26	20	presenting	present	VBG
cord-300805-apli48ih	26	21	with	with	IN
cord-300805-apli48ih	26	22	COVID-19	COVID-19	NNP
cord-300805-apli48ih	26	23	.	.	.
cord-300805-apli48ih	27	1	[	[	-LRB-
cord-300805-apli48ih	27	2	11	11	CD
cord-300805-apli48ih	27	3	]	]	-RRB-
cord-300805-apli48ih	27	4	[	[	-LRB-
cord-300805-apli48ih	27	5	12	12	CD
cord-300805-apli48ih	27	6	]	]	-RRB-
cord-300805-apli48ih	27	7	[	[	-LRB-
cord-300805-apli48ih	27	8	13	13	CD
cord-300805-apli48ih	27	9	]	]	-RRB-
cord-300805-apli48ih	28	1	[	[	-LRB-
cord-300805-apli48ih	28	2	14	14	CD
cord-300805-apli48ih	28	3	]	]	-RRB-
cord-300805-apli48ih	29	1	The	the	DT
cord-300805-apli48ih	29	2	coexisting	coexist	VBG
cord-300805-apli48ih	29	3	conditions	condition	NNS
cord-300805-apli48ih	29	4	such	such	JJ
cord-300805-apli48ih	29	5	as	as	IN
cord-300805-apli48ih	29	6	hypertension	hypertension	NN
cord-300805-apli48ih	29	7	,	,	,
cord-300805-apli48ih	29	8	older	old	JJR
cord-300805-apli48ih	29	9	age	age	NN
cord-300805-apli48ih	29	10	,	,	,
cord-300805-apli48ih	29	11	diabetes	diabetes	NN
cord-300805-apli48ih	29	12	,	,	,
cord-300805-apli48ih	29	13	cardiovascular	cardiovascular	JJ
cord-300805-apli48ih	29	14	disease	disease	NN
cord-300805-apli48ih	29	15	have	have	VBP
cord-300805-apli48ih	29	16	all	all	DT
cord-300805-apli48ih	29	17	been	be	VBN
cord-300805-apli48ih	29	18	reported	report	VBN
cord-300805-apli48ih	29	19	to	to	TO
cord-300805-apli48ih	29	20	be	be	VB
cord-300805-apli48ih	29	21	more	more	RBR
cord-300805-apli48ih	29	22	common	common	JJ
cord-300805-apli48ih	29	23	in	in	IN
cord-300805-apli48ih	29	24	patients	patient	NNS
cord-300805-apli48ih	29	25	with	with	IN
cord-300805-apli48ih	29	26	severe	severe	JJ
cord-300805-apli48ih	29	27	COVID-19	covid-19	NN
cord-300805-apli48ih	29	28	requiring	require	VBG
cord-300805-apli48ih	29	29	intensive	intensive	JJ
cord-300805-apli48ih	29	30	care	care	NN
cord-300805-apli48ih	29	31	.	.	.
cord-300805-apli48ih	30	1	[	[	-LRB-
cord-300805-apli48ih	30	2	14	14	CD
cord-300805-apli48ih	30	3	]	]	-RRB-
cord-300805-apli48ih	30	4	[	[	-LRB-
cord-300805-apli48ih	30	5	15	15	CD
cord-300805-apli48ih	30	6	]	]	-RRB-
cord-300805-apli48ih	30	7	[	[	-LRB-
cord-300805-apli48ih	30	8	16	16	CD
cord-300805-apli48ih	30	9	]	]	-RRB-
cord-300805-apli48ih	31	1	[	[	-LRB-
cord-300805-apli48ih	31	2	17	17	CD
cord-300805-apli48ih	31	3	]	]	-RRB-
cord-300805-apli48ih	32	1	The	the	DT
cord-300805-apli48ih	32	2	comorbidities	comorbiditie	NNS
cord-300805-apli48ih	32	3	,	,	,
cord-300805-apli48ih	32	4	including	include	VBG
cord-300805-apli48ih	32	5	hypertension	hypertension	NN
cord-300805-apli48ih	32	6	,	,	,
cord-300805-apli48ih	32	7	have	have	VBP
cord-300805-apli48ih	32	8	also	also	RB
cord-300805-apli48ih	32	9	been	be	VBN
cord-300805-apli48ih	32	10	significantly	significantly	RB
cord-300805-apli48ih	32	11	associated	associate	VBN
cord-300805-apli48ih	32	12	with	with	IN
cord-300805-apli48ih	32	13	adverse	adverse	JJ
cord-300805-apli48ih	32	14	outcomes	outcome	NNS
cord-300805-apli48ih	32	15	in	in	IN
cord-300805-apli48ih	32	16	COVID-19	COVID-19	NNP
cord-300805-apli48ih	32	17	such	such	JJ
cord-300805-apli48ih	32	18	as	as	IN
cord-300805-apli48ih	32	19	adult	adult	NN
cord-300805-apli48ih	32	20	respiratory	respiratory	JJ
cord-300805-apli48ih	32	21	distress	distress	NN
cord-300805-apli48ih	32	22	syndrome	syndrome	NN
cord-300805-apli48ih	32	23	,	,	,
cord-300805-apli48ih	32	24	cardiovascular	cardiovascular	JJ
cord-300805-apli48ih	32	25	compromise	compromise	NN
cord-300805-apli48ih	32	26	,	,	,
cord-300805-apli48ih	32	27	and	and	CC
cord-300805-apli48ih	32	28	mortality	mortality	NN
cord-300805-apli48ih	32	29	.	.	.
cord-300805-apli48ih	33	1	[	[	-LRB-
cord-300805-apli48ih	33	2	14	14	CD
cord-300805-apli48ih	33	3	]	]	-RRB-
cord-300805-apli48ih	33	4	[	[	-LRB-
cord-300805-apli48ih	33	5	15	15	CD
cord-300805-apli48ih	33	6	]	]	-RRB-
cord-300805-apli48ih	33	7	[	[	-LRB-
cord-300805-apli48ih	33	8	16	16	CD
cord-300805-apli48ih	33	9	]	]	-RRB-
cord-300805-apli48ih	33	10	[	[	-LRB-
cord-300805-apli48ih	33	11	17	17	CD
cord-300805-apli48ih	33	12	]	]	-RRB-
cord-300805-apli48ih	34	1	[	[	-LRB-
cord-300805-apli48ih	34	2	18	18	CD
cord-300805-apli48ih	34	3	]	]	-RRB-
cord-300805-apli48ih	35	1	Since	since	IN
cord-300805-apli48ih	35	2	the	the	DT
cord-300805-apli48ih	35	3	comorbidity	comorbidity	NN
cord-300805-apli48ih	35	4	of	of	IN
cord-300805-apli48ih	35	5	hypertension	hypertension	NN
cord-300805-apli48ih	35	6	has	have	VBZ
cord-300805-apli48ih	35	7	been	be	VBN
cord-300805-apli48ih	35	8	associated	associate	VBN
cord-300805-apli48ih	35	9	with	with	IN
cord-300805-apli48ih	35	10	severe	severe	JJ
cord-300805-apli48ih	35	11	COVID-19	covid-19	NN
cord-300805-apli48ih	35	12	and	and	CC
cord-300805-apli48ih	35	13	its	-PRON-	PRP$
cord-300805-apli48ih	35	14	consequences	consequence	NNS
cord-300805-apli48ih	35	15	,	,	,
cord-300805-apli48ih	35	16	the	the	DT
cord-300805-apli48ih	35	17	question	question	NN
cord-300805-apli48ih	35	18	has	have	VBZ
cord-300805-apli48ih	35	19	emerged	emerge	VBN
cord-300805-apli48ih	35	20	about	about	IN
cord-300805-apli48ih	35	21	the	the	DT
cord-300805-apli48ih	35	22	roles	role	NNS
cord-300805-apli48ih	35	23	of	of	IN
cord-300805-apli48ih	35	24	RAAS	RAAS	NNP
cord-300805-apli48ih	35	25	inhibitors	inhibitor	NNS
cord-300805-apli48ih	35	26	such	such	JJ
cord-300805-apli48ih	35	27	as	as	IN
cord-300805-apli48ih	35	28	ACEI	ACEI	NNP
cord-300805-apli48ih	35	29	and	and	CC
cord-300805-apli48ih	35	30	ARBS	arb	NNS
cord-300805-apli48ih	35	31	in	in	IN
cord-300805-apli48ih	35	32	the	the	DT
cord-300805-apli48ih	35	33	pathogenesis	pathogenesis	NN
cord-300805-apli48ih	35	34	of	of	IN
cord-300805-apli48ih	35	35	severe	severe	JJ
cord-300805-apli48ih	35	36	COVID-19	covid-19	NN
cord-300805-apli48ih	35	37	.	.	.
cord-300805-apli48ih	36	1	Given	give	VBN
cord-300805-apli48ih	36	2	that	that	IN
cord-300805-apli48ih	36	3	these	these	DT
cord-300805-apli48ih	36	4	RAAS	raa	NNS
cord-300805-apli48ih	36	5	inhibitors	inhibitor	NNS
cord-300805-apli48ih	36	6	are	be	VBP
cord-300805-apli48ih	36	7	common	common	JJ
cord-300805-apli48ih	36	8	therapies	therapy	NNS
cord-300805-apli48ih	36	9	for	for	IN
cord-300805-apli48ih	36	10	hypertension	hypertension	NN
cord-300805-apli48ih	36	11	and	and	CC
cord-300805-apli48ih	36	12	that	that	IN
cord-300805-apli48ih	36	13	they	-PRON-	PRP
cord-300805-apli48ih	36	14	may	may	MD
cord-300805-apli48ih	36	15	up	up	RB
cord-300805-apli48ih	36	16	-	-	VB
cord-300805-apli48ih	36	17	regulate	regulate	VB
cord-300805-apli48ih	36	18	the	the	DT
cord-300805-apli48ih	36	19	expression	expression	NN
cord-300805-apli48ih	36	20	of	of	IN
cord-300805-apli48ih	36	21	ACE2	ACE2	NNP
cord-300805-apli48ih	36	22	,	,	,
cord-300805-apli48ih	36	23	the	the	DT
cord-300805-apli48ih	36	24	clinical	clinical	JJ
cord-300805-apli48ih	36	25	concern	concern	NN
cord-300805-apli48ih	36	26	has	have	VBZ
cord-300805-apli48ih	36	27	been	be	VBN
cord-300805-apli48ih	36	28	formulated	formulate	VBN
cord-300805-apli48ih	36	29	that	that	DT
cord-300805-apli48ih	36	30	therapy	therapy	NN
cord-300805-apli48ih	36	31	with	with	IN
cord-300805-apli48ih	36	32	these	these	DT
cord-300805-apli48ih	36	33	agents	agent	NNS
cord-300805-apli48ih	36	34	may	may	MD
cord-300805-apli48ih	36	35	increase	increase	VB
cord-300805-apli48ih	36	36	the	the	DT
cord-300805-apli48ih	36	37	risk	risk	NN
cord-300805-apli48ih	36	38	and	and	CC
cord-300805-apli48ih	36	39	severity	severity	NN
cord-300805-apli48ih	36	40	of	of	IN
cord-300805-apli48ih	36	41	coronavirus	coronavirus	NN
cord-300805-apli48ih	36	42	infection	infection	NN
cord-300805-apli48ih	36	43	.	.	.
cord-300805-apli48ih	37	1	[	[	-LRB-
cord-300805-apli48ih	37	2	19	19	CD
cord-300805-apli48ih	37	3	]	]	-RRB-
cord-300805-apli48ih	37	4	[	[	-LRB-
cord-300805-apli48ih	37	5	20	20	CD
cord-300805-apli48ih	37	6	]	]	-RRB-
cord-300805-apli48ih	37	7	[	[	-LRB-
cord-300805-apli48ih	37	8	21	21	CD
cord-300805-apli48ih	37	9	]	]	-RRB-
cord-300805-apli48ih	38	1	[	[	-LRB-
cord-300805-apli48ih	38	2	22	22	CD
cord-300805-apli48ih	38	3	]	]	-RRB-
cord-300805-apli48ih	38	4	There	there	EX
cord-300805-apli48ih	38	5	is	be	VBZ
cord-300805-apli48ih	38	6	currently	currently	RB
cord-300805-apli48ih	38	7	insufficient	insufficient	JJ
cord-300805-apli48ih	38	8	evidence	evidence	NN
cord-300805-apli48ih	38	9	to	to	TO
cord-300805-apli48ih	38	10	address	address	VB
cord-300805-apli48ih	38	11	this	this	DT
cord-300805-apli48ih	38	12	question	question	NN
cord-300805-apli48ih	38	13	in	in	IN
cord-300805-apli48ih	38	14	a	a	DT
cord-300805-apli48ih	38	15	definitive	definitive	JJ
cord-300805-apli48ih	38	16	fashion	fashion	NN
cord-300805-apli48ih	38	17	.	.	.
cord-300805-apli48ih	39	1	1	1	LS
cord-300805-apli48ih	39	2	;	;	:
cord-300805-apli48ih	39	3	14	14	CD
cord-300805-apli48ih	39	4	The	the	DT
cord-300805-apli48ih	39	5	published	publish	VBN
cord-300805-apli48ih	39	6	literature	literature	NN
cord-300805-apli48ih	39	7	both	both	DT
cord-300805-apli48ih	39	8	in	in	IN
cord-300805-apli48ih	39	9	preclinical	preclinical	JJ
cord-300805-apli48ih	39	10	and	and	CC
cord-300805-apli48ih	39	11	clinical	clinical	JJ
cord-300805-apli48ih	39	12	studies	study	NNS
cord-300805-apli48ih	39	13	has	have	VBZ
cord-300805-apli48ih	39	14	conflicting	conflict	VBG
cord-300805-apli48ih	39	15	results	result	NNS
cord-300805-apli48ih	39	16	about	about	IN
cord-300805-apli48ih	39	17	the	the	DT
cord-300805-apli48ih	39	18	potential	potential	NN
cord-300805-apli48ih	39	19	for	for	IN
cord-300805-apli48ih	39	20	harm	harm	NN
cord-300805-apli48ih	39	21	with	with	IN
cord-300805-apli48ih	39	22	respect	respect	NN
cord-300805-apli48ih	39	23	to	to	IN
cord-300805-apli48ih	39	24	the	the	DT
cord-300805-apli48ih	39	25	interactions	interaction	NNS
cord-300805-apli48ih	39	26	between	between	IN
cord-300805-apli48ih	39	27	RAAS	RAAS	NNP
cord-300805-apli48ih	39	28	inhibitors	inhibitor	NNS
cord-300805-apli48ih	39	29	and	and	CC
cord-300805-apli48ih	39	30	coronavirus	coronavirus	NN
cord-300805-apli48ih	39	31	19	19	CD
cord-300805-apli48ih	39	32	.	.	.
cord-300805-apli48ih	40	1	Further	further	JJ
cord-300805-apli48ih	40	2	trials	trial	NNS
cord-300805-apli48ih	40	3	will	will	MD
cord-300805-apli48ih	40	4	likely	likely	RB
cord-300805-apli48ih	40	5	focus	focus	VB
cord-300805-apli48ih	40	6	on	on	IN
cord-300805-apli48ih	40	7	the	the	DT
cord-300805-apli48ih	40	8	current	current	JJ
cord-300805-apli48ih	40	9	evidence	evidence	NN
cord-300805-apli48ih	40	10	gaps	gap	NNS
cord-300805-apli48ih	40	11	related	relate	VBN
cord-300805-apli48ih	40	12	to	to	IN
cord-300805-apli48ih	40	13	this	this	DT
cord-300805-apli48ih	40	14	question	question	NN
cord-300805-apli48ih	40	15	in	in	IN
cord-300805-apli48ih	40	16	severe	severe	JJ
cord-300805-apli48ih	40	17	COVID-19	covid-19	JJ
cord-300805-apli48ih	40	18	including	include	VBG
cord-300805-apli48ih	40	19	mechanisms	mechanism	NNS
cord-300805-apli48ih	40	20	,	,	,
cord-300805-apli48ih	40	21	the	the	DT
cord-300805-apli48ih	40	22	prevalence	prevalence	NN
cord-300805-apli48ih	40	23	of	of	IN
cord-300805-apli48ih	40	24	RAAS	RAAS	NNP
cord-300805-apli48ih	40	25	inhibitors	inhibitor	NNS
cord-300805-apli48ih	40	26	,	,	,
cord-300805-apli48ih	40	27	and	and	CC
cord-300805-apli48ih	40	28	careful	careful	JJ
cord-300805-apli48ih	40	29	correlation	correlation	NN
cord-300805-apli48ih	40	30	of	of	IN
cord-300805-apli48ih	40	31	this	this	DT
cord-300805-apli48ih	40	32	prevalence	prevalence	NN
cord-300805-apli48ih	40	33	with	with	IN
cord-300805-apli48ih	40	34	clinical	clinical	JJ
cord-300805-apli48ih	40	35	outcomes	outcome	NNS
cord-300805-apli48ih	40	36	.	.	.
cord-300805-apli48ih	41	1	1	1	LS
cord-300805-apli48ih	41	2	;	;	:
cord-300805-apli48ih	41	3	18	18	CD
cord-300805-apli48ih	41	4	-	-	SYM
cord-300805-apli48ih	41	5	19	19	CD
cord-300805-apli48ih	42	1	Although	although	IN
cord-300805-apli48ih	42	2	hypertension	hypertension	NN
cord-300805-apli48ih	42	3	and	and	CC
cord-300805-apli48ih	42	4	consequent	consequent	JJ
cord-300805-apli48ih	42	5	exposure	exposure	NN
cord-300805-apli48ih	42	6	to	to	IN
cord-300805-apli48ih	42	7	ACEI	ACEI	NNP
cord-300805-apli48ih	42	8	and	and	CC
cord-300805-apli48ih	42	9	ARBS	arb	NNS
cord-300805-apli48ih	42	10	are	be	VBP
cord-300805-apli48ih	42	11	likely	likely	RB
cord-300805-apli48ih	42	12	common	common	JJ
cord-300805-apli48ih	42	13	in	in	IN
cord-300805-apli48ih	42	14	severe	severe	JJ
cord-300805-apli48ih	42	15	COVID-19	covid-19	NN
cord-300805-apli48ih	42	16	,	,	,
cord-300805-apli48ih	42	17	this	this	DT
cord-300805-apli48ih	42	18	association	association	NN
cord-300805-apli48ih	42	19	does	do	VBZ
cord-300805-apli48ih	42	20	link	link	VB
cord-300805-apli48ih	42	21	to	to	IN
cord-300805-apli48ih	42	22	causality	causality	NN
cord-300805-apli48ih	42	23	,	,	,
cord-300805-apli48ih	42	24	as	as	IN
cord-300805-apli48ih	42	25	outlined	outline	VBN
cord-300805-apli48ih	42	26	above	above	RB
cord-300805-apli48ih	42	27	.	.	.
cord-300805-apli48ih	43	1	[	[	-LRB-
cord-300805-apli48ih	43	2	23	23	CD
cord-300805-apli48ih	43	3	]	]	-RRB-
cord-300805-apli48ih	43	4	[	[	-LRB-
cord-300805-apli48ih	43	5	24	24	CD
cord-300805-apli48ih	43	6	]	]	-RRB-
cord-300805-apli48ih	44	1	There	there	EX
cord-300805-apli48ih	44	2	may	may	MD
cord-300805-apli48ih	44	3	also	also	RB
cord-300805-apli48ih	44	4	be	be	VB
cord-300805-apli48ih	44	5	confounding	confound	VBG
cord-300805-apli48ih	44	6	by	by	IN
cord-300805-apli48ih	44	7	association	association	NN
cord-300805-apli48ih	44	8	here	here	RB
cord-300805-apli48ih	44	9	in	in	IN
cord-300805-apli48ih	44	10	that	that	DT
cord-300805-apli48ih	44	11	patients	patient	NNS
cord-300805-apli48ih	44	12	with	with	IN
cord-300805-apli48ih	44	13	severe	severe	JJ
cord-300805-apli48ih	44	14	COVID-19	covid-19	NN
cord-300805-apli48ih	45	1	are	be	VBP
cord-300805-apli48ih	45	2	more	more	RBR
cord-300805-apli48ih	45	3	likely	likely	JJ
cord-300805-apli48ih	45	4	to	to	TO
cord-300805-apli48ih	45	5	be	be	VB
cord-300805-apli48ih	45	6	4	4	CD
cord-300805-apli48ih	45	7	hypertensive	hypertensive	JJ
cord-300805-apli48ih	45	8	,	,	,
cord-300805-apli48ih	45	9	diabetic	diabetic	JJ
cord-300805-apli48ih	45	10	and	and	CC
cord-300805-apli48ih	45	11	older	old	JJR
cord-300805-apli48ih	45	12	.	.	.
cord-300805-apli48ih	46	1	This	this	DT
cord-300805-apli48ih	46	2	comorbidity	comorbidity	NN
cord-300805-apli48ih	46	3	burden	burden	NN
cord-300805-apli48ih	46	4	rather	rather	RB
cord-300805-apli48ih	46	5	than	than	IN
cord-300805-apli48ih	46	6	the	the	DT
cord-300805-apli48ih	46	7	associated	associate	VBN
cord-300805-apli48ih	46	8	drug	drug	NN
cord-300805-apli48ih	46	9	therapy	therapy	NN
cord-300805-apli48ih	46	10	may	may	MD
cord-300805-apli48ih	46	11	better	better	RB
cord-300805-apli48ih	46	12	explain	explain	VB
cord-300805-apli48ih	46	13	the	the	DT
cord-300805-apli48ih	46	14	adverse	adverse	JJ
cord-300805-apli48ih	46	15	outcomes	outcome	NNS
cord-300805-apli48ih	46	16	in	in	IN
cord-300805-apli48ih	46	17	coronavirus	coronavirus	NN
cord-300805-apli48ih	46	18	infection	infection	NN
cord-300805-apli48ih	46	19	.	.	.
cord-300805-apli48ih	47	1	[	[	-LRB-
cord-300805-apli48ih	47	2	17	17	CD
cord-300805-apli48ih	47	3	]	]	-RRB-
cord-300805-apli48ih	47	4	[	[	-LRB-
cord-300805-apli48ih	47	5	18	18	CD
cord-300805-apli48ih	47	6	]	]	-RRB-
cord-300805-apli48ih	47	7	[	[	-LRB-
cord-300805-apli48ih	47	8	19	19	CD
cord-300805-apli48ih	47	9	]	]	-RRB-
cord-300805-apli48ih	48	1	In	in	IN
cord-300805-apli48ih	48	2	contrast	contrast	NN
cord-300805-apli48ih	48	3	,	,	,
cord-300805-apli48ih	48	4	animal	animal	NN
cord-300805-apli48ih	48	5	studies	study	NNS
cord-300805-apli48ih	48	6	have	have	VBP
cord-300805-apli48ih	48	7	clearly	clearly	RB
cord-300805-apli48ih	48	8	documented	document	VBN
cord-300805-apli48ih	48	9	that	that	IN
cord-300805-apli48ih	48	10	ACE2	ACE2	NNP
cord-300805-apli48ih	48	11	may	may	MD
cord-300805-apli48ih	48	12	have	have	VB
cord-300805-apli48ih	48	13	a	a	DT
cord-300805-apli48ih	48	14	protective	protective	JJ
cord-300805-apli48ih	48	15	role	role	NN
cord-300805-apli48ih	48	16	in	in	IN
cord-300805-apli48ih	48	17	acute	acute	JJ
cord-300805-apli48ih	48	18	lung	lung	NN
cord-300805-apli48ih	48	19	injury	injury	NN
cord-300805-apli48ih	48	20	related	relate	VBN
cord-300805-apli48ih	48	21	to	to	IN
cord-300805-apli48ih	48	22	coronavirus	coronavirus	NN
cord-300805-apli48ih	48	23	infection	infection	NN
cord-300805-apli48ih	48	24	.	.	.
cord-300805-apli48ih	49	1	[	[	-LRB-
cord-300805-apli48ih	49	2	25	25	CD
cord-300805-apli48ih	49	3	]	]	-RRB-
cord-300805-apli48ih	49	4	[	[	-LRB-
cord-300805-apli48ih	49	5	26	26	CD
cord-300805-apli48ih	49	6	]	]	-RRB-
cord-300805-apli48ih	50	1	Functional	functional	JJ
cord-300805-apli48ih	50	2	ACE2	ACE2	NNP
cord-300805-apli48ih	50	3	typically	typically	RB
cord-300805-apli48ih	50	4	converts	convert	VBZ
cord-300805-apli48ih	50	5	angiotensin	angiotensin	NN
cord-300805-apli48ih	50	6	II	II	NNP
cord-300805-apli48ih	50	7	to	to	IN
cord-300805-apli48ih	50	8	angiotensin	angiotensin	NN
cord-300805-apli48ih	50	9	1	1	CD
cord-300805-apli48ih	50	10	-	-	SYM
cord-300805-apli48ih	50	11	7	7	CD
cord-300805-apli48ih	50	12	,	,	,
cord-300805-apli48ih	50	13	thereby	thereby	RB
cord-300805-apli48ih	50	14	reducing	reduce	VBG
cord-300805-apli48ih	50	15	the	the	DT
cord-300805-apli48ih	50	16	adverse	adverse	JJ
cord-300805-apli48ih	50	17	effects	effect	NNS
cord-300805-apli48ih	50	18	of	of	IN
cord-300805-apli48ih	50	19	angiotensin	angiotensin	NN
cord-300805-apli48ih	50	20	II	II	NNP
cord-300805-apli48ih	50	21	via	via	IN
cord-300805-apli48ih	50	22	the	the	DT
cord-300805-apli48ih	50	23	angiotensin	angiotensin	NN
cord-300805-apli48ih	50	24	type	type	NN
cord-300805-apli48ih	50	25	I	-PRON-	PRP
cord-300805-apli48ih	50	26	receptor	receptor	VBP
cord-300805-apli48ih	50	27	in	in	IN
cord-300805-apli48ih	50	28	the	the	DT
cord-300805-apli48ih	50	29	lung	lung	NN
cord-300805-apli48ih	50	30	that	that	WDT
cord-300805-apli48ih	50	31	lead	lead	VBP
cord-300805-apli48ih	50	32	to	to	IN
cord-300805-apli48ih	50	33	acute	acute	JJ
cord-300805-apli48ih	50	34	lung	lung	NN
cord-300805-apli48ih	50	35	injury	injury	NN
cord-300805-apli48ih	50	36	.	.	.
cord-300805-apli48ih	51	1	1	1	LS
cord-300805-apli48ih	51	2	;	;	:
cord-300805-apli48ih	51	3	21	21	CD
cord-300805-apli48ih	51	4	Since	since	IN
cord-300805-apli48ih	51	5	therapy	therapy	NN
cord-300805-apli48ih	51	6	with	with	IN
cord-300805-apli48ih	51	7	ACEI	ACEI	NNP
cord-300805-apli48ih	51	8	and	and	CC
cord-300805-apli48ih	51	9	/	/	SYM
cord-300805-apli48ih	51	10	ot	ot	VBP
cord-300805-apli48ih	51	11	ARBS	ARBS	NNP
cord-300805-apli48ih	51	12	also	also	RB
cord-300805-apli48ih	51	13	reduces	reduce	VBZ
cord-300805-apli48ih	51	14	angiotensin	angiotensin	NN
cord-300805-apli48ih	51	15	II	ii	CD
cord-300805-apli48ih	51	16	levels	level	NNS
cord-300805-apli48ih	51	17	,	,	,
cord-300805-apli48ih	51	18	it	-PRON-	PRP
cord-300805-apli48ih	51	19	follows	follow	VBZ
cord-300805-apli48ih	51	20	that	that	IN
cord-300805-apli48ih	51	21	these	these	DT
cord-300805-apli48ih	51	22	agents	agent	NNS
cord-300805-apli48ih	51	23	may	may	MD
cord-300805-apli48ih	51	24	also	also	RB
cord-300805-apli48ih	51	25	protect	protect	VB
cord-300805-apli48ih	51	26	against	against	IN
cord-300805-apli48ih	51	27	acute	acute	JJ
cord-300805-apli48ih	51	28	lung	lung	NN
cord-300805-apli48ih	51	29	injury	injury	NN
cord-300805-apli48ih	51	30	in	in	IN
cord-300805-apli48ih	51	31	the	the	DT
cord-300805-apli48ih	51	32	setting	setting	NN
cord-300805-apli48ih	51	33	of	of	IN
cord-300805-apli48ih	51	34	COVID-19	COVID-19	NNP
cord-300805-apli48ih	51	35	.	.	.
cord-300805-apli48ih	51	36	 	 	_SP
cord-300805-apli48ih	52	1	Patients	patient	NNS
cord-300805-apli48ih	52	2	with	with	IN
cord-300805-apli48ih	52	3	severe	severe	JJ
cord-300805-apli48ih	52	4	COVID-19	COVID-19	NNP
cord-300805-apli48ih	52	5	may	may	MD
cord-300805-apli48ih	52	6	also	also	RB
cord-300805-apli48ih	52	7	develop	develop	VB
cord-300805-apli48ih	52	8	vasoplegic	vasoplegic	JJ
cord-300805-apli48ih	52	9	shock	shock	NN
cord-300805-apli48ih	52	10	with	with	IN
cord-300805-apli48ih	52	11	or	or	CC
cord-300805-apli48ih	52	12	without	without	IN
cord-300805-apli48ih	52	13	concomitant	concomitant	JJ
cord-300805-apli48ih	52	14	sepsis	sepsis	NN
cord-300805-apli48ih	52	15	.	.	.
cord-300805-apli48ih	53	1	30	30	CD
cord-300805-apli48ih	54	1	In	in	IN
cord-300805-apli48ih	54	2	the	the	DT
cord-300805-apli48ih	54	3	initial	initial	JJ
cord-300805-apli48ih	54	4	wave	wave	NN
cord-300805-apli48ih	54	5	of	of	IN
cord-300805-apli48ih	54	6	COVID-19	COVID-19	NNP
cord-300805-apli48ih	54	7	in	in	IN
cord-300805-apli48ih	54	8	Seattle	Seattle	NNP
cord-300805-apli48ih	54	9	,	,	,
cord-300805-apli48ih	54	10	patients	patient	NNS
cord-300805-apli48ih	54	11	with	with	IN
cord-300805-apli48ih	54	12	cardiovascular	cardiovascular	JJ
cord-300805-apli48ih	54	13	compromise	compromise	NN
cord-300805-apli48ih	54	14	seldom	seldom	RB
cord-300805-apli48ih	54	15	had	have	VBD
cord-300805-apli48ih	54	16	superinfection	superinfection	NN
cord-300805-apli48ih	54	17	,	,	,
cord-300805-apli48ih	54	18	suggesting	suggest	VBG
cord-300805-apli48ih	54	19	that	that	IN
cord-300805-apli48ih	54	20	the	the	DT
cord-300805-apli48ih	54	21	cardiovascular	cardiovascular	JJ
cord-300805-apli48ih	54	22	instability	instability	NN
cord-300805-apli48ih	54	23	was	be	VBD
cord-300805-apli48ih	54	24	mostly	mostly	RB
cord-300805-apli48ih	54	25	due	due	JJ
cord-300805-apli48ih	54	26	to	to	IN
cord-300805-apli48ih	54	27	the	the	DT
cord-300805-apli48ih	54	28	consequences	consequence	NNS
cord-300805-apli48ih	54	29	of	of	IN
cord-300805-apli48ih	54	30	viral	viral	JJ
cord-300805-apli48ih	54	31	infection	infection	NN
cord-300805-apli48ih	54	32	.	.	.
cord-300805-apli48ih	55	1	6	6	CD
cord-300805-apli48ih	56	1	Furthermore	furthermore	RB
cord-300805-apli48ih	56	2	,	,	,
cord-300805-apli48ih	56	3	in	in	IN
cord-300805-apli48ih	56	4	this	this	DT
cord-300805-apli48ih	56	5	patient	patient	JJ
cord-300805-apli48ih	56	6	cohort	cohort	NN
cord-300805-apli48ih	56	7	,	,	,
cord-300805-apli48ih	56	8	echocardiography	echocardiography	NN
cord-300805-apli48ih	56	9	also	also	RB
cord-300805-apli48ih	56	10	rarely	rarely	RB
cord-300805-apli48ih	56	11	identified	identify	VBD
cord-300805-apli48ih	56	12	ventricular	ventricular	JJ
cord-300805-apli48ih	56	13	dysfunction	dysfunction	NN
cord-300805-apli48ih	56	14	,	,	,
cord-300805-apli48ih	56	15	although	although	IN
cord-300805-apli48ih	56	16	myocarditis	myocarditis	NN
cord-300805-apli48ih	56	17	is	be	VBZ
cord-300805-apli48ih	56	18	a	a	DT
cord-300805-apli48ih	56	19	possibility	possibility	NN
cord-300805-apli48ih	56	20	in	in	IN
cord-300805-apli48ih	56	21	this	this	DT
cord-300805-apli48ih	56	22	disease	disease	NN
cord-300805-apli48ih	56	23	.	.	.
cord-300805-apli48ih	57	1	30	30	CD
cord-300805-apli48ih	58	1	This	this	DT
cord-300805-apli48ih	58	2	latest	late	JJS
cord-300805-apli48ih	58	3	data	datum	NNS
cord-300805-apli48ih	58	4	from	from	IN
cord-300805-apli48ih	58	5	the	the	DT
cord-300805-apli48ih	58	6	pandemic	pandemic	NN
cord-300805-apli48ih	58	7	in	in	IN
cord-300805-apli48ih	58	8	the	the	DT
cord-300805-apli48ih	58	9	United	United	NNP
cord-300805-apli48ih	58	10	States	States	NNP
cord-300805-apli48ih	58	11	suggests	suggest	VBZ
cord-300805-apli48ih	58	12	that	that	IN
cord-300805-apli48ih	58	13	vasoplegic	vasoplegic	JJ
cord-300805-apli48ih	58	14	shock	shock	NN
cord-300805-apli48ih	58	15	from	from	IN
cord-300805-apli48ih	58	16	the	the	DT
cord-300805-apli48ih	58	17	effects	effect	NNS
cord-300805-apli48ih	58	18	of	of	IN
cord-300805-apli48ih	58	19	the	the	DT
cord-300805-apli48ih	58	20	coronavirus	coronavirus	NN
cord-300805-apli48ih	58	21	is	be	VBZ
cord-300805-apli48ih	58	22	a	a	DT
cord-300805-apli48ih	58	23	likely	likely	JJ
cord-300805-apli48ih	58	24	clinical	clinical	JJ
cord-300805-apli48ih	58	25	presentation	presentation	NN
cord-300805-apli48ih	58	26	in	in	IN
cord-300805-apli48ih	58	27	severe	severe	JJ
cord-300805-apli48ih	58	28	COVID-19	covid-19	NN
cord-300805-apli48ih	58	29	.	.	.
cord-300805-apli48ih	58	30	 	 	_SP
cord-300805-apli48ih	59	1	The	the	DT
cord-300805-apli48ih	59	2	status	status	NN
cord-300805-apli48ih	59	3	quo	quo	FW
cord-300805-apli48ih	59	4	with	with	IN
cord-300805-apli48ih	59	5	respect	respect	NN
cord-300805-apli48ih	59	6	to	to	IN
cord-300805-apli48ih	59	7	ACEI	ACEI	NNP
cord-300805-apli48ih	59	8	and	and	CC
cord-300805-apli48ih	59	9	ARBS	ARBS	NNPS
cord-300805-apli48ih	59	10	in	in	IN
cord-300805-apli48ih	59	11	COVID-19	COVID-19	NNP
cord-300805-apli48ih	59	12	can	can	MD
cord-300805-apli48ih	59	13	be	be	VB
cord-300805-apli48ih	59	14	confusing	confusing	JJ
cord-300805-apli48ih	59	15	to	to	IN
cord-300805-apli48ih	59	16	clinicians	clinician	NNS
cord-300805-apli48ih	59	17	in	in	IN
cord-300805-apli48ih	59	18	the	the	DT
cord-300805-apli48ih	59	19	front	front	JJ
cord-300805-apli48ih	59	20	lines	line	NNS
cord-300805-apli48ih	59	21	of	of	IN
cord-300805-apli48ih	59	22	patient	patient	NN
cord-300805-apli48ih	59	23	care	care	NN
cord-300805-apli48ih	59	24	during	during	IN
cord-300805-apli48ih	59	25	the	the	DT
cord-300805-apli48ih	59	26	pandemic	pandemic	NN
cord-300805-apli48ih	59	27	,	,	,
cord-300805-apli48ih	59	28	given	give	VBN
cord-300805-apli48ih	59	29	the	the	DT
cord-300805-apli48ih	59	30	possibilities	possibility	NNS
cord-300805-apli48ih	59	31	for	for	IN
cord-300805-apli48ih	59	32	both	both	DT
cord-300805-apli48ih	59	33	benefit	benefit	NN
cord-300805-apli48ih	59	34	and	and	CC
cord-300805-apli48ih	59	35	6	6	CD
cord-300805-apli48ih	59	36	harm	harm	NN
cord-300805-apli48ih	59	37	.	.	.
cord-300805-apli48ih	60	1	[	[	-LRB-
cord-300805-apli48ih	60	2	14	14	CD
cord-300805-apli48ih	60	3	]	]	-RRB-
cord-300805-apli48ih	60	4	[	[	-LRB-
cord-300805-apli48ih	60	5	15	15	CD
cord-300805-apli48ih	60	6	]	]	-RRB-
cord-300805-apli48ih	61	1	This	this	DT
cord-300805-apli48ih	61	2	priority	priority	NN
cord-300805-apli48ih	61	3	for	for	IN
cord-300805-apli48ih	61	4	clinical	clinical	JJ
cord-300805-apli48ih	61	5	guidance	guidance	NN
cord-300805-apli48ih	61	6	during	during	IN
cord-300805-apli48ih	61	7	the	the	DT
cord-300805-apli48ih	61	8	coronavirus	coronavirus	NN
cord-300805-apli48ih	61	9	virus	virus	NN
cord-300805-apli48ih	61	10	has	have	VBZ
cord-300805-apli48ih	61	11	prompted	prompt	VBN
cord-300805-apli48ih	61	12	recent	recent	JJ
cord-300805-apli48ih	61	13	statements	statement	NNS
cord-300805-apli48ih	61	14	from	from	IN
cord-300805-apli48ih	61	15	multiple	multiple	JJ
cord-300805-apli48ih	61	16	professional	professional	JJ
cord-300805-apli48ih	61	17	societies	society	NNS
cord-300805-apli48ih	61	18	including	include	VBG
cord-300805-apli48ih	61	19	the	the	DT
cord-300805-apli48ih	61	20	Canadian	Canadian	NNP
cord-300805-apli48ih	61	21	Cardiovascular	Cardiovascular	NNP
cord-300805-apli48ih	61	22	Society	Society	NNP
cord-300805-apli48ih	61	23	,	,	,
cord-300805-apli48ih	61	24	the	the	DT
cord-300805-apli48ih	61	25	European	European	NNP
cord-300805-apli48ih	61	26	Society	Society	NNP
cord-300805-apli48ih	61	27	of	of	IN
cord-300805-apli48ih	61	28	Hypertension	Hypertension	NNP
cord-300805-apli48ih	61	29	,	,	,
cord-300805-apli48ih	61	30	the	the	DT
cord-300805-apli48ih	61	31	International	International	NNP
cord-300805-apli48ih	61	32	Society	Society	NNP
cord-300805-apli48ih	61	33	of	of	IN
cord-300805-apli48ih	61	34	Hypertension	Hypertension	NNP
cord-300805-apli48ih	61	35	,	,	,
cord-300805-apli48ih	61	36	the	the	DT
cord-300805-apli48ih	61	37	European	European	NNP
cord-300805-apli48ih	61	38	Society	Society	NNP
cord-300805-apli48ih	61	39	of	of	IN
cord-300805-apli48ih	61	40	Cardiology	Cardiology	NNP
cord-300805-apli48ih	61	41	and	and	CC
cord-300805-apli48ih	61	42	American	American	NNP
cord-300805-apli48ih	61	43	College	College	NNP
cord-300805-apli48ih	61	44	of	of	IN
cord-300805-apli48ih	61	45	Cardiology	Cardiology	NNP
cord-300805-apli48ih	61	46	.	.	.
cord-300805-apli48ih	62	1	[	[	-LRB-
cord-300805-apli48ih	62	2	13	13	CD
cord-300805-apli48ih	62	3	]	]	-RRB-
cord-300805-apli48ih	62	4	[	[	-LRB-
cord-300805-apli48ih	62	5	14	14	CD
cord-300805-apli48ih	62	6	]	]	-RRB-
cord-300805-apli48ih	63	1	In	in	IN
cord-300805-apli48ih	63	2	summary	summary	NN
cord-300805-apli48ih	63	3	,	,	,
cord-300805-apli48ih	63	4	the	the	DT
cord-300805-apli48ih	63	5	expert	expert	JJ
cord-300805-apli48ih	63	6	consensus	consensus	NN
cord-300805-apli48ih	63	7	from	from	IN
cord-300805-apli48ih	63	8	all	all	PDT
cord-300805-apli48ih	63	9	these	these	DT
cord-300805-apli48ih	63	10	professional	professional	JJ
cord-300805-apli48ih	63	11	societies	society	NNS
cord-300805-apli48ih	63	12	is	be	VBZ
cord-300805-apli48ih	63	13	that	that	IN
cord-300805-apli48ih	63	14	patients	patient	NNS
cord-300805-apli48ih	63	15	with	with	IN
cord-300805-apli48ih	63	16	COVID-19	COVID-19	NNP
cord-300805-apli48ih	63	17	should	should	MD
cord-300805-apli48ih	63	18	continue	continue	VB
cord-300805-apli48ih	63	19	their	-PRON-	PRP$
cord-300805-apli48ih	63	20	regular	regular	JJ
cord-300805-apli48ih	63	21	home	home	NN
cord-300805-apli48ih	63	22	blood	blood	NN
cord-300805-apli48ih	63	23	antihypertensive	antihypertensive	JJ
cord-300805-apli48ih	63	24	regimen	regimen	NN
cord-300805-apli48ih	63	25	,	,	,
cord-300805-apli48ih	63	26	even	even	RB
cord-300805-apli48ih	63	27	if	if	IN
cord-300805-apli48ih	63	28	it	-PRON-	PRP
cord-300805-apli48ih	63	29	includes	include	VBZ
cord-300805-apli48ih	63	30	ACEI	ACEI	NNP
cord-300805-apli48ih	63	31	and	and	CC
cord-300805-apli48ih	63	32	ARBS	arb	NNS
cord-300805-apli48ih	63	33	.	.	.
cord-300805-apli48ih	64	1	14	14	CD
cord-300805-apli48ih	65	1	In	in	IN
cord-300805-apli48ih	65	2	patients	patient	NNS
cord-300805-apli48ih	65	3	with	with	IN
cord-300805-apli48ih	65	4	COVID-19	COVID-19	NNP
cord-300805-apli48ih	65	5	who	who	WP
cord-300805-apli48ih	65	6	develop	develop	VBP
cord-300805-apli48ih	65	7	shock	shock	NN
cord-300805-apli48ih	65	8	,	,	,
cord-300805-apli48ih	65	9	the	the	DT
cord-300805-apli48ih	65	10	vasodilator	vasodilator	NN
cord-300805-apli48ih	65	11	regimen	regimen	NN
cord-300805-apli48ih	65	12	with	with	IN
cord-300805-apli48ih	65	13	RAAS	RAAS	NNP
cord-300805-apli48ih	65	14	inhibitors	inhibitor	NNS
cord-300805-apli48ih	65	15	can	can	MD
cord-300805-apli48ih	65	16	be	be	VB
cord-300805-apli48ih	65	17	discontinued	discontinue	VBN
cord-300805-apli48ih	65	18	.	.	.
cord-300805-apli48ih	66	1	14	14	CD
cord-300805-apli48ih	67	1	Although	although	IN
cord-300805-apli48ih	67	2	not	not	RB
cord-300805-apli48ih	67	3	specifically	specifically	RB
cord-300805-apli48ih	67	4	addressed	address	VBN
cord-300805-apli48ih	67	5	in	in	IN
cord-300805-apli48ih	67	6	these	these	DT
cord-300805-apli48ih	67	7	multiple	multiple	JJ
cord-300805-apli48ih	67	8	professional	professional	JJ
cord-300805-apli48ih	67	9	guidelines	guideline	NNS
cord-300805-apli48ih	67	10	,	,	,
cord-300805-apli48ih	67	11	the	the	DT
cord-300805-apli48ih	67	12	roles	role	NNS
cord-300805-apli48ih	67	13	of	of	IN
cord-300805-apli48ih	67	14	rescue	rescue	NN
cord-300805-apli48ih	67	15	therapy	therapy	NN
cord-300805-apli48ih	67	16	for	for	IN
cord-300805-apli48ih	67	17	vasoplegic	vasoplegic	JJ
cord-300805-apli48ih	67	18	shock	shock	NN
cord-300805-apli48ih	67	19	can	can	MD
cord-300805-apli48ih	67	20	also	also	RB
cord-300805-apli48ih	67	21	be	be	VB
cord-300805-apli48ih	67	22	considered	consider	VBN
cord-300805-apli48ih	67	23	in	in	IN
cord-300805-apli48ih	67	24	refractory	refractory	JJ
cord-300805-apli48ih	67	25	cases	case	NNS
cord-300805-apli48ih	67	26	,	,	,
cord-300805-apli48ih	67	27	including	include	VBG
cord-300805-apli48ih	67	28	angiotensin	angiotensin	NN
cord-300805-apli48ih	67	29	II	II	NNP
cord-300805-apli48ih	67	30	.	.	.
cord-300805-apli48ih	68	1	2;4	2;4	CD
cord-300805-apli48ih	68	2	-	-	SYM
cord-300805-apli48ih	68	3	5	5	CD
cord-300805-apli48ih	69	1	Furthermore	furthermore	RB
cord-300805-apli48ih	69	2	,	,	,
cord-300805-apli48ih	69	3	in	in	IN
cord-300805-apli48ih	69	4	treatment	treatment	NN
cord-300805-apli48ih	69	5	-	-	HYPH
cord-300805-apli48ih	69	6	resistant	resistant	JJ
cord-300805-apli48ih	69	7	cases	case	NNS
cord-300805-apli48ih	69	8	of	of	IN
cord-300805-apli48ih	69	9	COPVID-19	COPVID-19	NNP
cord-300805-apli48ih	69	10	,	,	,
cord-300805-apli48ih	69	11	the	the	DT
cord-300805-apli48ih	69	12	mechanisms	mechanism	NNS
cord-300805-apli48ih	69	13	for	for	IN
cord-300805-apli48ih	69	14	cardiogenic	cardiogenic	JJ
cord-300805-apli48ih	69	15	shock	shock	NN
cord-300805-apli48ih	69	16	and	and	CC
cord-300805-apli48ih	69	17	the	the	DT
cord-300805-apli48ih	69	18	supportive	supportive	JJ
cord-300805-apli48ih	69	19	roles	role	NNS
cord-300805-apli48ih	69	20	of	of	IN
cord-300805-apli48ih	69	21	extracorporeal	extracorporeal	JJ
cord-300805-apli48ih	69	22	membrane	membrane	NN
cord-300805-apli48ih	69	23	oxygenation	oxygenation	NN
cord-300805-apli48ih	69	24	should	should	MD
cord-300805-apli48ih	69	25	be	be	VB
cord-300805-apli48ih	69	26	entertained	entertain	VBN
cord-300805-apli48ih	69	27	early	early	RB
cord-300805-apli48ih	69	28	,	,	,
cord-300805-apli48ih	69	29	as	as	IN
cord-300805-apli48ih	69	30	these	these	DT
cord-300805-apli48ih	69	31	considerations	consideration	NNS
cord-300805-apli48ih	69	32	can	can	MD
cord-300805-apli48ih	69	33	often	often	RB
cord-300805-apli48ih	69	34	lead	lead	VB
cord-300805-apli48ih	69	35	to	to	IN
cord-300805-apli48ih	69	36	therapeutic	therapeutic	JJ
cord-300805-apli48ih	69	37	breakthroughs	breakthrough	NNS
cord-300805-apli48ih	69	38	.	.	.
cord-300805-apli48ih	70	1	[	[	-LRB-
cord-300805-apli48ih	70	2	29	29	CD
cord-300805-apli48ih	70	3	]	]	-RRB-
cord-300805-apli48ih	70	4	[	[	-LRB-
cord-300805-apli48ih	70	5	30	30	CD
cord-300805-apli48ih	70	6	]	]	-RRB-
cord-300805-apli48ih	71	1	[	[	-LRB-
cord-300805-apli48ih	71	2	31	31	CD
cord-300805-apli48ih	71	3	]	]	-RRB-
cord-300805-apli48ih	71	4	 	 	_SP
cord-300805-apli48ih	72	1	The	the	DT
cord-300805-apli48ih	72	2	spectrum	spectrum	NN
cord-300805-apli48ih	72	3	of	of	IN
cord-300805-apli48ih	72	4	severe	severe	JJ
cord-300805-apli48ih	72	5	COVID-19	covid-19	NN
cord-300805-apli48ih	72	6	includes	include	VBZ
cord-300805-apli48ih	72	7	significant	significant	JJ
cord-300805-apli48ih	72	8	disruption	disruption	NN
cord-300805-apli48ih	72	9	of	of	IN
cord-300805-apli48ih	72	10	the	the	DT
cord-300805-apli48ih	72	11	RAAS	raa	NNS
cord-300805-apli48ih	72	12	,	,	,
cord-300805-apli48ih	72	13	with	with	IN
cord-300805-apli48ih	72	14	significant	significant	JJ
cord-300805-apli48ih	72	15	implications	implication	NNS
cord-300805-apli48ih	72	16	for	for	IN
cord-300805-apli48ih	72	17	organ	organ	NN
cord-300805-apli48ih	72	18	dysfunction	dysfunction	NN
cord-300805-apli48ih	72	19	,	,	,
cord-300805-apli48ih	72	20	vascular	vascular	JJ
cord-300805-apli48ih	72	21	tone	tone	NN
cord-300805-apli48ih	72	22	,	,	,
cord-300805-apli48ih	72	23	as	as	RB
cord-300805-apli48ih	72	24	well	well	RB
cord-300805-apli48ih	72	25	as	as	IN
cord-300805-apli48ih	72	26	therapy	therapy	NN
cord-300805-apli48ih	72	27	with	with	IN
cord-300805-apli48ih	72	28	ACEI	ACEI	NNP
cord-300805-apli48ih	72	29	and	and	CC
cord-300805-apli48ih	72	30	ARBS	arb	NNS
cord-300805-apli48ih	72	31	.	.	.
cord-300805-apli48ih	73	1	Although	although	IN
cord-300805-apli48ih	73	2	clinical	clinical	JJ
cord-300805-apli48ih	73	3	trials	trial	NNS
cord-300805-apli48ih	73	4	are	be	VBP
cord-300805-apli48ih	73	5	in	in	IN
cord-300805-apli48ih	73	6	progress	progress	NN
cord-300805-apli48ih	73	7	to	to	TO
cord-300805-apli48ih	73	8	close	close	VB
cord-300805-apli48ih	73	9	the	the	DT
cord-300805-apli48ih	73	10	current	current	JJ
cord-300805-apli48ih	73	11	evidence	evidence	NN
cord-300805-apli48ih	73	12	gaps	gap	NNS
cord-300805-apli48ih	73	13	,	,	,
cord-300805-apli48ih	73	14	the	the	DT
cord-300805-apli48ih	73	15	current	current	JJ
cord-300805-apli48ih	73	16	expert	expert	NN
cord-300805-apli48ih	73	17	consensus	consensus	NN
cord-300805-apli48ih	73	18	has	have	VBZ
cord-300805-apli48ih	73	19	recommended	recommend	VBN
cord-300805-apli48ih	73	20	that	that	IN
cord-300805-apli48ih	73	21	in	in	IN
cord-300805-apli48ih	73	22	most	most	JJS
cord-300805-apli48ih	73	23	cases	case	NNS
cord-300805-apli48ih	73	24	,	,	,
cord-300805-apli48ih	73	25	existing	exist	VBG
cord-300805-apli48ih	73	26	therapy	therapy	NN
cord-300805-apli48ih	73	27	with	with	IN
cord-300805-apli48ih	73	28	ACEI	ACEI	NNP
cord-300805-apli48ih	73	29	and	and	CC
cord-300805-apli48ih	73	30	ARBS	arb	NNS
cord-300805-apli48ih	73	31	be	be	VB
cord-300805-apli48ih	73	32	continued	continue	VBN
cord-300805-apli48ih	73	33	.	.	.
cord-300805-apli48ih	74	1	In	in	IN
cord-300805-apli48ih	74	2	the	the	DT
cord-300805-apli48ih	74	3	setting	setting	NN
cord-300805-apli48ih	74	4	of	of	IN
cord-300805-apli48ih	74	5	circulatory	circulatory	JJ
cord-300805-apli48ih	74	6	shock	shock	NN
cord-300805-apli48ih	74	7	,	,	,
cord-300805-apli48ih	74	8	these	these	DT
cord-300805-apli48ih	74	9	agents	agent	NNS
cord-300805-apli48ih	74	10	may	may	MD
cord-300805-apli48ih	74	11	be	be	VB
cord-300805-apli48ih	74	12	discontinued	discontinue	VBN
cord-300805-apli48ih	74	13	and	and	CC
cord-300805-apli48ih	74	14	early	early	JJ
cord-300805-apli48ih	74	15	consideration	consideration	NN
cord-300805-apli48ih	74	16	of	of	IN
cord-300805-apli48ih	74	17	therapies	therapy	NNS
cord-300805-apli48ih	74	18	for	for	IN
cord-300805-apli48ih	74	19	medical	medical	JJ
cord-300805-apli48ih	74	20	and	and	CC
cord-300805-apli48ih	74	21	mechanical	mechanical	JJ
cord-300805-apli48ih	74	22	rescue	rescue	NN
cord-300805-apli48ih	74	23	may	may	MD
cord-300805-apli48ih	74	24	be	be	VB
cord-300805-apli48ih	74	25	lifesaving	lifesave	VBG
cord-300805-apli48ih	74	26	.	.	.
cord-300805-apli48ih	75	1	The	the	DT
cord-300805-apli48ih	75	2	management	management	NN
cord-300805-apli48ih	75	3	of	of	IN
cord-300805-apli48ih	75	4	patients	patient	NNS
cord-300805-apli48ih	75	5	through	through	IN
cord-300805-apli48ih	75	6	this	this	DT
cord-300805-apli48ih	75	7	pandemic	pandemic	NN
cord-300805-apli48ih	75	8	must	must	MD
cord-300805-apli48ih	75	9	also	also	RB
cord-300805-apli48ih	75	10	consider	consider	VB
cord-300805-apli48ih	75	11	infection	infection	NN
cord-300805-apli48ih	75	12	control	control	NN
cord-300805-apli48ih	75	13	to	to	TO
cord-300805-apli48ih	75	14	prevent	prevent	VB
cord-300805-apli48ih	75	15	further	further	JJ
cord-300805-apli48ih	75	16	viral	viral	JJ
cord-300805-apli48ih	75	17	transmission	transmission	NN
cord-300805-apli48ih	75	18	.	.	.
cord-300805-apli48ih	76	1	Renin	renin	NN
cord-300805-apli48ih	76	2	-	-	HYPH
cord-300805-apli48ih	76	3	angiotensin	angiotensin	NN
cord-300805-apli48ih	76	4	-	-	HYPH
cord-300805-apli48ih	76	5	aldosterone	aldosterone	NN
cord-300805-apli48ih	76	6	system	system	NN
cord-300805-apli48ih	76	7	inhibitors	inhibitor	NNS
cord-300805-apli48ih	76	8	in	in	IN
cord-300805-apli48ih	76	9	patients	patient	NNS
cord-300805-apli48ih	76	10	with	with	IN
cord-300805-apli48ih	76	11	COVID-19	COVID-19	NNP
cord-300805-apli48ih	76	12	Angiotensin	Angiotensin	NNP
cord-300805-apli48ih	76	13	II	II	NNP
cord-300805-apli48ih	76	14	for	for	IN
cord-300805-apli48ih	76	15	the	the	DT
cord-300805-apli48ih	76	16	treatment	treatment	NN
cord-300805-apli48ih	76	17	of	of	IN
cord-300805-apli48ih	76	18	COVID-19-related	COVID-19-related	NNP
cord-300805-apli48ih	76	19	vasodilatory	vasodilatory	NNP
cord-300805-apli48ih	76	20	shock	shock	NN
cord-300805-apli48ih	77	1	The	the	DT
cord-300805-apli48ih	77	2	vasoactive	vasoactive	JJ
cord-300805-apli48ih	77	3	Mas	Mas	NNP
cord-300805-apli48ih	77	4	receptor	receptor	NN
cord-300805-apli48ih	77	5	in	in	IN
cord-300805-apli48ih	77	6	essential	essential	JJ
cord-300805-apli48ih	77	7	hypertension	hypertension	NN
cord-300805-apli48ih	77	8	Vasoplegia	Vasoplegia	NNP
cord-300805-apli48ih	77	9	during	during	IN
cord-300805-apli48ih	77	10	cardiopulmonary	cardiopulmonary	JJ
cord-300805-apli48ih	77	11	bypass	bypass	NN
cord-300805-apli48ih	77	12	:	:	:
cord-300805-apli48ih	77	13	current	current	JJ
cord-300805-apli48ih	77	14	literature	literature	NN
cord-300805-apli48ih	77	15	and	and	CC
cord-300805-apli48ih	77	16	rescue	rescue	NN
cord-300805-apli48ih	77	17	therapy	therapy	NN
cord-300805-apli48ih	77	18	options	option	NNS
cord-300805-apli48ih	77	19	Vasoplegia	Vasoplegia	NNP
cord-300805-apli48ih	77	20	after	after	IN
cord-300805-apli48ih	77	21	cardiovascular	cardiovascular	JJ
cord-300805-apli48ih	77	22	procedurespathophysiology	procedurespathophysiology	NN
cord-300805-apli48ih	77	23	and	and	CC
cord-300805-apli48ih	77	24	targeted	target	VBN
cord-300805-apli48ih	77	25	therapy	therapy	NN
cord-300805-apli48ih	77	26	COVID-19	COVID-19	,
cord-300805-apli48ih	77	27	in	in	IN
cord-300805-apli48ih	77	28	critically	critically	RB
cord-300805-apli48ih	77	29	ill	ill	JJ
cord-300805-apli48ih	77	30	patients	patient	NNS
cord-300805-apli48ih	77	31	in	in	IN
cord-300805-apli48ih	77	32	the	the	DT
cord-300805-apli48ih	77	33	Seattle	Seattle	NNP
cord-300805-apli48ih	77	34	region	region	NN
cord-300805-apli48ih	78	1	-case	-case	NNP
cord-300805-apli48ih	78	2	series	series	NNP
cord-300805-apli48ih	79	1	Clinical	clinical	JJ
cord-300805-apli48ih	79	2	course	course	NN
cord-300805-apli48ih	79	3	and	and	CC
cord-300805-apli48ih	79	4	outcomes	outcome	NNS
cord-300805-apli48ih	79	5	of	of	IN
cord-300805-apli48ih	79	6	critically	critically	RB
cord-300805-apli48ih	79	7	ill	ill	JJ
cord-300805-apli48ih	79	8	patients	patient	NNS
cord-300805-apli48ih	79	9	with	with	IN
cord-300805-apli48ih	79	10	SARS	SARS	NNP
cord-300805-apli48ih	79	11	-	-	HYPH
cord-300805-apli48ih	79	12	CoV-2	CoV-2	NNP
cord-300805-apli48ih	79	13	pneumonia	pneumonia	NN
cord-300805-apli48ih	79	14	in	in	IN
cord-300805-apli48ih	79	15	Wuhan	Wuhan	NNP
cord-300805-apli48ih	79	16	,	,	,
cord-300805-apli48ih	79	17	China	China	NNP
cord-300805-apli48ih	79	18	:	:	:
cord-300805-apli48ih	79	19	a	a	DT
cord-300805-apli48ih	79	20	single	single	RB
cord-300805-apli48ih	79	21	-	-	HYPH
cord-300805-apli48ih	79	22	centered	centered	JJ
cord-300805-apli48ih	79	23	,	,	,
cord-300805-apli48ih	79	24	retrospective	retrospective	JJ
cord-300805-apli48ih	79	25	,	,	,
cord-300805-apli48ih	79	26	observational	observational	JJ
cord-300805-apli48ih	79	27	study	study	NN
cord-300805-apli48ih	79	28	Outbreak	outbreak	NN
cord-300805-apli48ih	79	29	of	of	IN
cord-300805-apli48ih	79	30	a	a	DT
cord-300805-apli48ih	79	31	new	new	JJ
cord-300805-apli48ih	79	32	coronavirus	coronavirus	NN
cord-300805-apli48ih	79	33	:	:	:
cord-300805-apli48ih	79	34	what	what	WP
cord-300805-apli48ih	79	35	anaesthetists	anaesthetist	NNS
cord-300805-apli48ih	79	36	should	should	MD
cord-300805-apli48ih	79	37	know	know	VB
cord-300805-apli48ih	79	38	Chinese	Chinese	NNP
cord-300805-apli48ih	79	39	Society	Society	NNP
cord-300805-apli48ih	79	40	of	of	IN
cord-300805-apli48ih	79	41	Anesthesiologists	Anesthesiologists	NNPS
cord-300805-apli48ih	80	1	expert	expert	JJ
cord-300805-apli48ih	80	2	consensus	consensus	NN
cord-300805-apli48ih	80	3	on	on	IN
cord-300805-apli48ih	80	4	anesthetic	anesthetic	JJ
cord-300805-apli48ih	80	5	management	management	NN
cord-300805-apli48ih	80	6	of	of	IN
cord-300805-apli48ih	80	7	cardiac	cardiac	JJ
cord-300805-apli48ih	80	8	surgical	surgical	JJ
cord-300805-apli48ih	80	9	patients	patient	NNS
cord-300805-apli48ih	80	10	with	with	IN
cord-300805-apli48ih	80	11	suspected	suspect	VBN
cord-300805-apli48ih	80	12	or	or	CC
cord-300805-apli48ih	80	13	confirmed	confirm	VBN
cord-300805-apli48ih	80	14	coronavirus	coronavirus	NN
cord-300805-apli48ih	80	15	disease	disease	NN
cord-300805-apli48ih	80	16	2019	2019	CD
cord-300805-apli48ih	80	17	Anesthetic	anesthetic	JJ
cord-300805-apli48ih	80	18	management	management	NN
cord-300805-apli48ih	80	19	of	of	IN
cord-300805-apli48ih	80	20	patients	patient	NNS
cord-300805-apli48ih	80	21	undergoing	undergo	VBG
cord-300805-apli48ih	80	22	aortic	aortic	JJ
cord-300805-apli48ih	80	23	dissection	dissection	NN
cord-300805-apli48ih	80	24	repair	repair	NN
cord-300805-apli48ih	80	25	with	with	IN
cord-300805-apli48ih	80	26	suspected	suspect	VBN
cord-300805-apli48ih	80	27	severe	severe	JJ
cord-300805-apli48ih	80	28	acute	acute	JJ
cord-300805-apli48ih	80	29	respiratory	respiratory	JJ
cord-300805-apli48ih	80	30	syndrome	syndrome	NN
cord-300805-apli48ih	80	31	Coronavirus-2	coronavirus-2	NN
cord-300805-apli48ih	80	32	infection	infection	NN
cord-300805-apli48ih	80	33	Clinical	clinical	JJ
cord-300805-apli48ih	80	34	characteristics	characteristic	NNS
cord-300805-apli48ih	80	35	of	of	IN
cord-300805-apli48ih	80	36	coronavirus	coronavirus	NN
cord-300805-apli48ih	80	37	disease	disease	NN
cord-300805-apli48ih	80	38	2019	2019	CD
cord-300805-apli48ih	80	39	in	in	IN
cord-300805-apli48ih	80	40	China	China	NNP
cord-300805-apli48ih	80	41	Clinical	clinical	JJ
cord-300805-apli48ih	80	42	features	feature	NNS
cord-300805-apli48ih	80	43	of	of	IN
cord-300805-apli48ih	80	44	patients	patient	NNS
cord-300805-apli48ih	80	45	with	with	IN
cord-300805-apli48ih	80	46	2019	2019	CD
cord-300805-apli48ih	80	47	novel	novel	JJ
cord-300805-apli48ih	80	48	coronavirus	coronavirus	NN
cord-300805-apli48ih	80	49	in	in	IN
cord-300805-apli48ih	80	50	Wuhan	Wuhan	NNP
cord-300805-apli48ih	80	51	Clinical	Clinical	NNP
cord-300805-apli48ih	80	52	management	management	NN
cord-300805-apli48ih	80	53	of	of	IN
cord-300805-apli48ih	80	54	severe	severe	JJ
cord-300805-apli48ih	80	55	acute	acute	JJ
cord-300805-apli48ih	80	56	respiratory	respiratory	JJ
cord-300805-apli48ih	80	57	infection	infection	NN
cord-300805-apli48ih	80	58	when	when	WRB
cord-300805-apli48ih	80	59	novel	novel	JJ
cord-300805-apli48ih	80	60	coronavirus	coronavirus	NN
cord-300805-apli48ih	80	61	(	(	-LRB-
cord-300805-apli48ih	80	62	2019-nCoV	2019-ncov	CD
cord-300805-apli48ih	80	63	)	)	-RRB-
cord-300805-apli48ih	80	64	infection	infection	NN
cord-300805-apli48ih	80	65	is	be	VBZ
cord-300805-apli48ih	80	66	suspected	suspect	VBN
cord-300805-apli48ih	80	67	-interim	-interim	NN
cord-300805-apli48ih	80	68	guidance	guidance	NN
cord-300805-apli48ih	80	69	.	.	.
cord-300805-apli48ih	81	1	(	(	-LRB-
cord-300805-apli48ih	81	2	the	the	DT
cord-300805-apli48ih	81	3	full	full	JJ
cord-300805-apli48ih	81	4	details	detail	NNS
cord-300805-apli48ih	81	5	are	be	VBP
cord-300805-apli48ih	81	6	available	available	JJ
cord-300805-apli48ih	81	7	at	at	IN
cord-300805-apli48ih	81	8	this	this	DT
cord-300805-apli48ih	81	9	link	link	NN
cord-300805-apli48ih	81	10	-last	-last	NN
cord-300805-apli48ih	81	11	accessed	access	VBN
cord-300805-apli48ih	81	12	March	March	NNP
cord-300805-apli48ih	81	13	Cardiovascular	Cardiovascular	NNP
cord-300805-apli48ih	81	14	considerations	consideration	NNS
cord-300805-apli48ih	81	15	for	for	IN
cord-300805-apli48ih	81	16	patients	patient	NNS
cord-300805-apli48ih	81	17	,	,	,
cord-300805-apli48ih	81	18	health	health	NN
cord-300805-apli48ih	81	19	care	care	NN
cord-300805-apli48ih	81	20	workers	worker	NNS
cord-300805-apli48ih	81	21	,	,	,
cord-300805-apli48ih	81	22	and	and	CC
cord-300805-apli48ih	81	23	health	health	NN
cord-300805-apli48ih	81	24	systems	system	NNS
cord-300805-apli48ih	81	25	during	during	IN
cord-300805-apli48ih	81	26	the	the	DT
cord-300805-apli48ih	81	27	coronavirus	coronavirus	NN
cord-300805-apli48ih	81	28	disease	disease	NN
cord-300805-apli48ih	81	29	2019	2019	CD
cord-300805-apli48ih	81	30	(	(	-LRB-
cord-300805-apli48ih	81	31	COVID-19	covid-19	VB
cord-300805-apli48ih	81	32	)	)	-RRB-
cord-300805-apli48ih	81	33	pandemic	pandemic	NN
cord-300805-apli48ih	81	34	Potential	potential	JJ
cord-300805-apli48ih	81	35	effects	effect	NNS
cord-300805-apli48ih	81	36	of	of	IN
cord-300805-apli48ih	81	37	coronaviruses	coronaviruse	NNS
cord-300805-apli48ih	81	38	on	on	IN
cord-300805-apli48ih	81	39	the	the	DT
cord-300805-apli48ih	81	40	cardiovascular	cardiovascular	JJ
cord-300805-apli48ih	81	41	system	system	NN
cord-300805-apli48ih	81	42	:	:	:
cord-300805-apli48ih	82	1	a	a	DT
cord-300805-apli48ih	82	2	review	review	NN
cord-300805-apli48ih	83	1	CSC	CSC	NNP
cord-300805-apli48ih	83	2	expert	expert	NN
cord-300805-apli48ih	83	3	consensus	consensus	NN
cord-300805-apli48ih	83	4	on	on	IN
cord-300805-apli48ih	83	5	principles	principle	NNS
cord-300805-apli48ih	83	6	of	of	IN
cord-300805-apli48ih	83	7	clinical	clinical	JJ
cord-300805-apli48ih	83	8	management	management	NN
cord-300805-apli48ih	83	9	Coronavirus	Coronavirus	NNP
cord-300805-apli48ih	83	10	disease	disease	NN
cord-300805-apli48ih	83	11	2019	2019	CD
cord-300805-apli48ih	83	12	(	(	-LRB-
cord-300805-apli48ih	83	13	COVID-19	COVID-19	NNP
cord-300805-apli48ih	83	14	)	)	-RRB-
cord-300805-apli48ih	83	15	and	and	CC
cord-300805-apli48ih	83	16	cardiovascular	cardiovascular	JJ
cord-300805-apli48ih	83	17	disease	disease	NN
cord-300805-apli48ih	84	1	COVID-19	covid-19	VB
cord-300805-apli48ih	84	2	and	and	CC
cord-300805-apli48ih	84	3	the	the	DT
cord-300805-apli48ih	84	4	cardiovascular	cardiovascular	JJ
cord-300805-apli48ih	84	5	system	system	NN
cord-300805-apli48ih	84	6	Coronaviruses	Coronaviruses	NNPS
cord-300805-apli48ih	84	7	and	and	CC
cord-300805-apli48ih	84	8	the	the	DT
cord-300805-apli48ih	84	9	cardiovascular	cardiovascular	JJ
cord-300805-apli48ih	84	10	system	system	NN
cord-300805-apli48ih	84	11	:	:	:
cord-300805-apli48ih	84	12	acute	acute	JJ
cord-300805-apli48ih	84	13	and	and	CC
cord-300805-apli48ih	84	14	long	long	JJ
cord-300805-apli48ih	84	15	-	-	HYPH
cord-300805-apli48ih	84	16	term	term	NN
cord-300805-apli48ih	84	17	implications	implication	NNS
cord-300805-apli48ih	85	1	Can	Can	MD
cord-300805-apli48ih	85	2	angiotensin	angiotensin	NN
cord-300805-apli48ih	85	3	receptor	receptor	NN
cord-300805-apli48ih	85	4	-	-	HYPH
cord-300805-apli48ih	85	5	blocking	block	VBG
cord-300805-apli48ih	85	6	drugs	drug	NNS
cord-300805-apli48ih	85	7	perhaps	perhaps	RB
cord-300805-apli48ih	85	8	be	be	VB
cord-300805-apli48ih	85	9	harmful	harmful	JJ
cord-300805-apli48ih	85	10	in	in	IN
cord-300805-apli48ih	85	11	the	the	DT
cord-300805-apli48ih	85	12	COVID-19	covid-19	JJ
cord-300805-apli48ih	85	13	pandemic	pandemic	NN
cord-300805-apli48ih	85	14	?	?	.
cord-300805-apli48ih	86	1	SARS	SARS	NNP
cord-300805-apli48ih	86	2	-	-	HYPH
cord-300805-apli48ih	86	3	CoV2	CoV2	NNP
cord-300805-apli48ih	86	4	:	:	:
cord-300805-apli48ih	87	1	Should	Should	MD
cord-300805-apli48ih	87	2	inhibitors	inhibitor	NNS
cord-300805-apli48ih	87	3	of	of	IN
cord-300805-apli48ih	87	4	the	the	DT
cord-300805-apli48ih	87	5	reninangiotensin	reninangiotensin	NNP
cord-300805-apli48ih	87	6	system	system	NN
cord-300805-apli48ih	87	7	be	be	VB
cord-300805-apli48ih	87	8	withdrawn	withdraw	VBN
cord-300805-apli48ih	87	9	in	in	IN
cord-300805-apli48ih	87	10	patients	patient	NNS
cord-300805-apli48ih	87	11	with	with	IN
cord-300805-apli48ih	87	12	COVID-19	COVID-19	NNP
cord-300805-apli48ih	87	13	?	?	.
cord-300805-apli48ih	88	1	Hypothesis	hypothesis	NN
cord-300805-apli48ih	88	2	:	:	:
cord-300805-apli48ih	89	1	angiotensin	angiotensin	NN
cord-300805-apli48ih	89	2	-	-	HYPH
cord-300805-apli48ih	89	3	converting	convert	VBG
cord-300805-apli48ih	89	4	enzyme	enzyme	NN
cord-300805-apli48ih	89	5	inhibitors	inhibitor	NNS
cord-300805-apli48ih	89	6	and	and	CC
cord-300805-apli48ih	89	7	angiotensin	angiotensin	NN
cord-300805-apli48ih	89	8	receptor	receptor	NN
cord-300805-apli48ih	89	9	blockers	blocker	NNS
cord-300805-apli48ih	89	10	may	may	MD
cord-300805-apli48ih	89	11	increase	increase	VB
cord-300805-apli48ih	89	12	the	the	DT
cord-300805-apli48ih	89	13	risk	risk	NN
cord-300805-apli48ih	89	14	of	of	IN
cord-300805-apli48ih	89	15	severe	severe	JJ
cord-300805-apli48ih	89	16	COVID-19	covid-19	JJ
cord-300805-apli48ih	89	17	Prevalence	prevalence	NN
cord-300805-apli48ih	89	18	of	of	IN
cord-300805-apli48ih	89	19	comorbidities	comorbiditie	NNS
cord-300805-apli48ih	89	20	in	in	IN
cord-300805-apli48ih	89	21	the	the	DT
cord-300805-apli48ih	89	22	novel	novel	JJ
cord-300805-apli48ih	89	23	Wuhan	Wuhan	NNP
cord-300805-apli48ih	89	24	coronavirus	coronavirus	NN
cord-300805-apli48ih	89	25	(	(	-LRB-
cord-300805-apli48ih	89	26	COVID-19	covid-19	VB
cord-300805-apli48ih	89	27	)	)	-RRB-
cord-300805-apli48ih	89	28	infection	infection	NN
cord-300805-apli48ih	89	29	:	:	:
cord-300805-apli48ih	89	30	a	a	DT
cord-300805-apli48ih	89	31	systematic	systematic	JJ
cord-300805-apli48ih	89	32	review	review	NN
cord-300805-apli48ih	89	33	and	and	CC
cord-300805-apli48ih	89	34	meta	meta	NNP
cord-300805-apli48ih	89	35	-	-	HYPH
cord-300805-apli48ih	89	36	analysis	analysis	NN
cord-300805-apli48ih	89	37	Comorbidity	comorbidity	NN
cord-300805-apli48ih	89	38	and	and	CC
cord-300805-apli48ih	89	39	its	-PRON-	PRP$
cord-300805-apli48ih	89	40	impact	impact	NN
cord-300805-apli48ih	89	41	on	on	IN
cord-300805-apli48ih	89	42	1590	1590	CD
cord-300805-apli48ih	89	43	patients	patient	NNS
cord-300805-apli48ih	89	44	with	with	IN
cord-300805-apli48ih	89	45	COVID-19	COVID-19	NNP
cord-300805-apli48ih	89	46	in	in	IN
cord-300805-apli48ih	89	47	China	China	NNP
cord-300805-apli48ih	89	48	:	:	:
cord-300805-apli48ih	89	49	a	a	DT
cord-300805-apli48ih	89	50	nationwide	nationwide	JJ
cord-300805-apli48ih	89	51	analysis	analysis	NN
cord-300805-apli48ih	89	52	Angiotensin	angiotensin	NN
cord-300805-apli48ih	89	53	-	-	HYPH
cord-300805-apli48ih	89	54	converting	convert	VBG
cord-300805-apli48ih	89	55	enzyme	enzyme	NN
cord-300805-apli48ih	89	56	2	2	CD
cord-300805-apli48ih	89	57	protects	protect	VBZ
cord-300805-apli48ih	89	58	from	from	IN
cord-300805-apli48ih	89	59	severe	severe	JJ
cord-300805-apli48ih	89	60	acute	acute	JJ
cord-300805-apli48ih	89	61	lung	lung	NN
cord-300805-apli48ih	89	62	failure	failure	NN
cord-300805-apli48ih	90	1	A	a	DT
cord-300805-apli48ih	90	2	crucial	crucial	JJ
cord-300805-apli48ih	90	3	role	role	NN
cord-300805-apli48ih	90	4	of	of	IN
cord-300805-apli48ih	90	5	angiotensin	angiotensin	NN
cord-300805-apli48ih	90	6	converting	convert	VBG
cord-300805-apli48ih	90	7	enzyme	enzyme	NN
cord-300805-apli48ih	90	8	2	2	CD
cord-300805-apli48ih	90	9	(	(	-LRB-
cord-300805-apli48ih	90	10	ACE2	ACE2	NNP
cord-300805-apli48ih	90	11	)	)	-RRB-
cord-300805-apli48ih	90	12	in	in	IN
cord-300805-apli48ih	90	13	SARS	SARS	NNP
cord-300805-apli48ih	90	14	coronavirus	coronavirus	NN
cord-300805-apli48ih	90	15	-	-	HYPH
cord-300805-apli48ih	90	16	induced	induce	VBN
cord-300805-apli48ih	90	17	lung	lung	NN
cord-300805-apli48ih	90	18	injury	injury	NN
cord-300805-apli48ih	90	19	Angiotensin	Angiotensin	NNP
cord-300805-apli48ih	90	20	receptor	receptor	NN
cord-300805-apli48ih	90	21	blockers	blocker	NNS
cord-300805-apli48ih	90	22	as	as	IN
cord-300805-apli48ih	90	23	tentative	tentative	JJ
cord-300805-apli48ih	90	24	SARS	SARS	NNP
cord-300805-apli48ih	90	25	-	-	HYPH
cord-300805-apli48ih	90	26	CoV-2	CoV-2	NNP
cord-300805-apli48ih	90	27	therapeutics	therapeutic	NNS
cord-300805-apli48ih	90	28	Angiotensin	Angiotensin	NNP
cord-300805-apli48ih	90	29	-	-	HYPH
cord-300805-apli48ih	90	30	converting	convert	VBG
cord-300805-apli48ih	90	31	enzyme	enzyme	NN
cord-300805-apli48ih	90	32	2	2	CD
cord-300805-apli48ih	90	33	(	(	-LRB-
cord-300805-apli48ih	90	34	ACE2	ACE2	NNP
cord-300805-apli48ih	90	35	)	)	-RRB-
cord-300805-apli48ih	90	36	as	as	IN
cord-300805-apli48ih	90	37	a	a	DT
cord-300805-apli48ih	90	38	SARS	SARS	NNP
cord-300805-apli48ih	90	39	CoV-2	CoV-2	NNP
cord-300805-apli48ih	90	40	receptor	receptor	NN
cord-300805-apli48ih	90	41	:	:	:
cord-300805-apli48ih	90	42	molecular	molecular	JJ
cord-300805-apli48ih	90	43	mechanisms	mechanism	NNS
cord-300805-apli48ih	90	44	and	and	CC
cord-300805-apli48ih	90	45	potential	potential	JJ
cord-300805-apli48ih	90	46	therapeutic	therapeutic	JJ
cord-300805-apli48ih	90	47	target	target	NN
cord-300805-apli48ih	90	48	Cardiovascular	cardiovascular	JJ
cord-300805-apli48ih	90	49	consequences	consequence	NNS
cord-300805-apli48ih	90	50	and	and	CC
cord-300805-apli48ih	90	51	considerations	consideration	NNS
cord-300805-apli48ih	90	52	of	of	IN
cord-300805-apli48ih	90	53	coronavirus	coronavirus	NN
cord-300805-apli48ih	90	54	infectionperspectives	infectionperspective	NNS
cord-300805-apli48ih	90	55	for	for	IN
cord-300805-apli48ih	90	56	the	the	DT
cord-300805-apli48ih	90	57	cardiothoracic	cardiothoracic	JJ
cord-300805-apli48ih	90	58	anesthesiologist	anesthesiologist	NN
cord-300805-apli48ih	90	59	and	and	CC
cord-300805-apli48ih	90	60	intensivist	intensivist	NN
cord-300805-apli48ih	90	61	during	during	IN
cord-300805-apli48ih	90	62	the	the	DT
cord-300805-apli48ih	90	63	coronavirus	coronavirus	NN
cord-300805-apli48ih	90	64	crisis	crisis	NN
cord-300805-apli48ih	90	65	Management	management	NN
cord-300805-apli48ih	90	66	strategies	strategy	NNS
cord-300805-apli48ih	90	67	for	for	IN
cord-300805-apli48ih	90	68	severe	severe	JJ
cord-300805-apli48ih	90	69	and	and	CC
cord-300805-apli48ih	90	70	refractory	refractory	JJ
cord-300805-apli48ih	90	71	acute	acute	JJ
cord-300805-apli48ih	90	72	respiratory	respiratory	JJ
cord-300805-apli48ih	90	73	distress	distress	NN
cord-300805-apli48ih	90	74	syndrome	syndrome	NN
cord-300805-apli48ih	90	75	:	:	:
cord-300805-apli48ih	90	76	where	where	WRB
cord-300805-apli48ih	90	77	do	do	VBP
cord-300805-apli48ih	90	78	we	-PRON-	PRP
cord-300805-apli48ih	90	79	stand	stand	VB
cord-300805-apli48ih	90	80	in	in	IN
cord-300805-apli48ih	90	81	2018	2018	CD
cord-300805-apli48ih	90	82	?	?	.
cord-300805-apli48ih	91	1	Extracorporeal	extracorporeal	JJ
cord-300805-apli48ih	91	2	membrane	membrane	NN
cord-300805-apli48ih	91	3	oxygenation	oxygenation	NN
cord-300805-apli48ih	92	1	-crucial	-crucial	JJ
cord-300805-apli48ih	92	2	considerations	consideration	NNS
cord-300805-apli48ih	92	3	during	during	IN
cord-300805-apli48ih	92	4	the	the	DT
cord-300805-apli48ih	92	5	coronavirus	coronavirus	NN
cord-300805-apli48ih	92	6	crisis	crisis	NN