id sid tid token lemma pos cord-300360-h6gr91eg 1 1 key key JJ cord-300360-h6gr91eg 1 2 : : : cord-300360-h6gr91eg 1 3 cord-300360-h6gr91eg cord-300360-h6gr91eg NN cord-300360-h6gr91eg 1 4 authors author NNS cord-300360-h6gr91eg 1 5 : : : cord-300360-h6gr91eg 1 6 Górski Górski NNP cord-300360-h6gr91eg 1 7 , , , cord-300360-h6gr91eg 1 8 Andrzej Andrzej NNP cord-300360-h6gr91eg 1 9 ; ; : cord-300360-h6gr91eg 1 10 Międzybrodzki Międzybrodzki NNP cord-300360-h6gr91eg 1 11 , , , cord-300360-h6gr91eg 1 12 Ryszard Ryszard NNP cord-300360-h6gr91eg 1 13 ; ; : cord-300360-h6gr91eg 1 14 Żaczek Żaczek NNP cord-300360-h6gr91eg 1 15 , , , cord-300360-h6gr91eg 1 16 Maciej Maciej NNP cord-300360-h6gr91eg 1 17 ; ; : cord-300360-h6gr91eg 1 18 Borysowski Borysowski NNP cord-300360-h6gr91eg 1 19 , , , cord-300360-h6gr91eg 2 1 Jan Jan NNP cord-300360-h6gr91eg 2 2 title title NN cord-300360-h6gr91eg 2 3 : : : cord-300360-h6gr91eg 2 4 Phages phage NNS cord-300360-h6gr91eg 2 5 in in IN cord-300360-h6gr91eg 2 6 the the DT cord-300360-h6gr91eg 2 7 fight fight NN cord-300360-h6gr91eg 2 8 against against IN cord-300360-h6gr91eg 2 9 COVID-19 COVID-19 NNP cord-300360-h6gr91eg 2 10 ? ? . cord-300360-h6gr91eg 3 1 date date NN cord-300360-h6gr91eg 3 2 : : : cord-300360-h6gr91eg 3 3 2020 2020 CD cord-300360-h6gr91eg 3 4 - - HYPH cord-300360-h6gr91eg 3 5 08 08 CD cord-300360-h6gr91eg 3 6 - - SYM cord-300360-h6gr91eg 3 7 26 26 CD cord-300360-h6gr91eg 3 8 journal journal NN cord-300360-h6gr91eg 3 9 : : : cord-300360-h6gr91eg 4 1 Future future JJ cord-300360-h6gr91eg 4 2 microbiology microbiology NN cord-300360-h6gr91eg 4 3 DOI doi NN cord-300360-h6gr91eg 4 4 : : : cord-300360-h6gr91eg 5 1 10.2217 10.2217 LS cord-300360-h6gr91eg 5 2 / / SYM cord-300360-h6gr91eg 5 3 fmb-2020 fmb-2020 NN cord-300360-h6gr91eg 5 4 - - HYPH cord-300360-h6gr91eg 5 5 0082 0082 CD cord-300360-h6gr91eg 6 1 sha sha NNP cord-300360-h6gr91eg 6 2 : : : cord-300360-h6gr91eg 6 3 ae963006a5d82fa808d17d0ca2d9c342ed38575d ae963006a5d82fa808d17d0ca2d9c342ed38575d NNP cord-300360-h6gr91eg 6 4 doc_id doc_id CD cord-300360-h6gr91eg 6 5 : : : cord-300360-h6gr91eg 6 6 300360 300360 CD cord-300360-h6gr91eg 6 7 cord_uid cord_uid NN cord-300360-h6gr91eg 6 8 : : : cord-300360-h6gr91eg 7 1 h6gr91eg h6gr91eg UH cord-300360-h6gr91eg 7 2 nan nan NNP cord-300360-h6gr91eg 8 1 The the DT cord-300360-h6gr91eg 8 2 COVID-19 COVID-19 NNP cord-300360-h6gr91eg 8 3 pandemic pandemic NN cord-300360-h6gr91eg 8 4 has have VBZ cord-300360-h6gr91eg 8 5 overwhelmed overwhelm VBN cord-300360-h6gr91eg 8 6 healthcare healthcare NN cord-300360-h6gr91eg 8 7 systems system NNS cord-300360-h6gr91eg 8 8 , , , cord-300360-h6gr91eg 8 9 putting put VBG cord-300360-h6gr91eg 8 10 staff staff NN cord-300360-h6gr91eg 8 11 under under IN cord-300360-h6gr91eg 8 12 stress stress NN cord-300360-h6gr91eg 8 13 and and CC cord-300360-h6gr91eg 8 14 bringing bring VBG cord-300360-h6gr91eg 8 15 unprecedented unprecedented JJ cord-300360-h6gr91eg 8 16 challenges challenge NNS cord-300360-h6gr91eg 8 17 to to IN cord-300360-h6gr91eg 8 18 the the DT cord-300360-h6gr91eg 8 19 economy economy NN cord-300360-h6gr91eg 8 20 and and CC cord-300360-h6gr91eg 8 21 social social JJ cord-300360-h6gr91eg 8 22 life life NN cord-300360-h6gr91eg 8 23 [ [ -LRB- cord-300360-h6gr91eg 8 24 1 1 CD cord-300360-h6gr91eg 8 25 ] ] -RRB- cord-300360-h6gr91eg 8 26 . . . cord-300360-h6gr91eg 9 1 At at RB cord-300360-h6gr91eg 9 2 least least RBS cord-300360-h6gr91eg 9 3 15 15 CD cord-300360-h6gr91eg 9 4 % % NN cord-300360-h6gr91eg 9 5 of of IN cord-300360-h6gr91eg 9 6 COVID-19 covid-19 CD cord-300360-h6gr91eg 9 7 patients patient NNS cord-300360-h6gr91eg 9 8 suffer suffer VBP cord-300360-h6gr91eg 9 9 from from IN cord-300360-h6gr91eg 9 10 severe severe JJ cord-300360-h6gr91eg 9 11 disease disease NN cord-300360-h6gr91eg 9 12 , , , cord-300360-h6gr91eg 9 13 so so RB cord-300360-h6gr91eg 9 14 effective effective JJ cord-300360-h6gr91eg 9 15 treatment treatment NN cord-300360-h6gr91eg 9 16 is be VBZ cord-300360-h6gr91eg 9 17 desperately desperately RB cord-300360-h6gr91eg 9 18 needed need VBN cord-300360-h6gr91eg 9 19 . . . cord-300360-h6gr91eg 10 1 The the DT cord-300360-h6gr91eg 10 2 international international JJ cord-300360-h6gr91eg 10 3 scientific scientific JJ cord-300360-h6gr91eg 10 4 community community NN cord-300360-h6gr91eg 10 5 has have VBZ cord-300360-h6gr91eg 10 6 engaged engage VBN cord-300360-h6gr91eg 10 7 in in IN cord-300360-h6gr91eg 10 8 many many JJ cord-300360-h6gr91eg 10 9 studies study NNS cord-300360-h6gr91eg 10 10 to to TO cord-300360-h6gr91eg 10 11 find find VB cord-300360-h6gr91eg 10 12 drugs drug NNS cord-300360-h6gr91eg 10 13 to to TO cord-300360-h6gr91eg 10 14 treat treat VB cord-300360-h6gr91eg 10 15 the the DT cord-300360-h6gr91eg 10 16 disease disease NN cord-300360-h6gr91eg 10 17 and and CC cord-300360-h6gr91eg 10 18 there there EX cord-300360-h6gr91eg 10 19 are be VBP cord-300360-h6gr91eg 10 20 reports report NNS cord-300360-h6gr91eg 10 21 suggesting suggest VBG cord-300360-h6gr91eg 10 22 the the DT cord-300360-h6gr91eg 10 23 potential potential JJ cord-300360-h6gr91eg 10 24 efficacy efficacy NN cord-300360-h6gr91eg 10 25 of of IN cord-300360-h6gr91eg 10 26 some some DT cord-300360-h6gr91eg 10 27 agents agent NNS cord-300360-h6gr91eg 10 28 . . . cord-300360-h6gr91eg 11 1 However however RB cord-300360-h6gr91eg 11 2 , , , cord-300360-h6gr91eg 11 3 it -PRON- PRP cord-300360-h6gr91eg 11 4 must must MD cord-300360-h6gr91eg 11 5 be be VB cord-300360-h6gr91eg 11 6 emphasized emphasize VBN cord-300360-h6gr91eg 11 7 that that IN cord-300360-h6gr91eg 11 8 although although IN cord-300360-h6gr91eg 11 9 " " `` cord-300360-h6gr91eg 11 10 many many JJ cord-300360-h6gr91eg 11 11 drugs drug NNS cord-300360-h6gr91eg 11 12 have have VBP cord-300360-h6gr91eg 11 13 in in FW cord-300360-h6gr91eg 11 14 vitro vitro FW cord-300360-h6gr91eg 11 15 activity activity NN cord-300360-h6gr91eg 11 16 against against IN cord-300360-h6gr91eg 11 17 different different JJ cord-300360-h6gr91eg 11 18 coronaviruses coronaviruse NNS cord-300360-h6gr91eg 11 19 , , , cord-300360-h6gr91eg 11 20 no no DT cord-300360-h6gr91eg 11 21 clinical clinical JJ cord-300360-h6gr91eg 11 22 evidence evidence NN cord-300360-h6gr91eg 11 23 currently currently RB cord-300360-h6gr91eg 11 24 supports support VBZ cord-300360-h6gr91eg 11 25 the the DT cord-300360-h6gr91eg 11 26 efficacy efficacy NN cord-300360-h6gr91eg 11 27 and and CC cord-300360-h6gr91eg 11 28 safety safety NN cord-300360-h6gr91eg 11 29 of of IN cord-300360-h6gr91eg 11 30 any any DT cord-300360-h6gr91eg 11 31 drug drug NN cord-300360-h6gr91eg 11 32 in in IN cord-300360-h6gr91eg 11 33 humans human NNS cord-300360-h6gr91eg 11 34 " " '' cord-300360-h6gr91eg 11 35 [ [ -LRB- cord-300360-h6gr91eg 11 36 2 2 CD cord-300360-h6gr91eg 11 37 ] ] -RRB- cord-300360-h6gr91eg 11 38 . . . cord-300360-h6gr91eg 12 1 At at IN cord-300360-h6gr91eg 12 2 the the DT cord-300360-h6gr91eg 12 3 same same JJ cord-300360-h6gr91eg 12 4 time time NN cord-300360-h6gr91eg 12 5 , , , cord-300360-h6gr91eg 12 6 the the DT cord-300360-h6gr91eg 12 7 progress progress NN cord-300360-h6gr91eg 12 8 of of IN cord-300360-h6gr91eg 12 9 clinical clinical JJ cord-300360-h6gr91eg 12 10 investigation investigation NN cord-300360-h6gr91eg 12 11 is be VBZ cord-300360-h6gr91eg 12 12 under under IN cord-300360-h6gr91eg 12 13 threat threat NN cord-300360-h6gr91eg 12 14 as as IN cord-300360-h6gr91eg 12 15 the the DT cord-300360-h6gr91eg 12 16 pandemic pandemic NN cord-300360-h6gr91eg 12 17 shuts shut VBZ cord-300360-h6gr91eg 12 18 down down RP cord-300360-h6gr91eg 12 19 research research NN cord-300360-h6gr91eg 12 20 on on IN cord-300360-h6gr91eg 12 21 drugs drug NNS cord-300360-h6gr91eg 12 22 for for IN cord-300360-h6gr91eg 12 23 multiple multiple JJ cord-300360-h6gr91eg 12 24 other other JJ cord-300360-h6gr91eg 12 25 diseases disease NNS cord-300360-h6gr91eg 12 26 , , , cord-300360-h6gr91eg 12 27 including include VBG cord-300360-h6gr91eg 12 28 cancer cancer NN cord-300360-h6gr91eg 12 29 , , , cord-300360-h6gr91eg 12 30 where where WRB cord-300360-h6gr91eg 12 31 , , , cord-300360-h6gr91eg 12 32 as as IN cord-300360-h6gr91eg 12 33 some some DT cord-300360-h6gr91eg 12 34 experts expert NNS cord-300360-h6gr91eg 12 35 believe believe VBP cord-300360-h6gr91eg 12 36 , , , cord-300360-h6gr91eg 12 37 clinical clinical JJ cord-300360-h6gr91eg 12 38 studies study NNS cord-300360-h6gr91eg 12 39 have have VBP cord-300360-h6gr91eg 12 40 been be VBN cord-300360-h6gr91eg 12 41 cut cut VBN cord-300360-h6gr91eg 12 42 to to IN cord-300360-h6gr91eg 12 43 almost almost RB cord-300360-h6gr91eg 12 44 zero zero CD cord-300360-h6gr91eg 12 45 [ [ -LRB- cord-300360-h6gr91eg 12 46 3 3 CD cord-300360-h6gr91eg 12 47 ] ] -RRB- cord-300360-h6gr91eg 12 48 . . . cord-300360-h6gr91eg 13 1 In in IN cord-300360-h6gr91eg 13 2 this this DT cord-300360-h6gr91eg 13 3 extreme extreme JJ cord-300360-h6gr91eg 13 4 situation situation NN cord-300360-h6gr91eg 13 5 repurposing repurpose VBG cord-300360-h6gr91eg 13 6 drugs drug NNS cord-300360-h6gr91eg 13 7 may may MD cord-300360-h6gr91eg 13 8 be be VB cord-300360-h6gr91eg 13 9 the the DT cord-300360-h6gr91eg 13 10 appropriate appropriate JJ cord-300360-h6gr91eg 13 11 strategy strategy NN cord-300360-h6gr91eg 13 12 to to TO cord-300360-h6gr91eg 13 13 seek seek VB cord-300360-h6gr91eg 13 14 a a DT cord-300360-h6gr91eg 13 15 prompt prompt NN cord-300360-h6gr91eg 13 16 and and CC cord-300360-h6gr91eg 13 17 hopefully hopefully RB cord-300360-h6gr91eg 13 18 efficient efficient JJ cord-300360-h6gr91eg 13 19 therapeutic therapeutic JJ cord-300360-h6gr91eg 13 20 response response NN cord-300360-h6gr91eg 13 21 to to IN cord-300360-h6gr91eg 13 22 the the DT cord-300360-h6gr91eg 13 23 COVID-19 COVID-19 NNP cord-300360-h6gr91eg 13 24 pandemic pandemic NN cord-300360-h6gr91eg 13 25 . . . cord-300360-h6gr91eg 14 1 A a DT cord-300360-h6gr91eg 14 2 good good JJ cord-300360-h6gr91eg 14 3 example example NN cord-300360-h6gr91eg 14 4 of of IN cord-300360-h6gr91eg 14 5 such such PDT cord-300360-h6gr91eg 14 6 a a DT cord-300360-h6gr91eg 14 7 strategy strategy NN cord-300360-h6gr91eg 14 8 is be VBZ cord-300360-h6gr91eg 14 9 the the DT cord-300360-h6gr91eg 14 10 current current JJ cord-300360-h6gr91eg 14 11 enthusiasm enthusiasm NN cord-300360-h6gr91eg 14 12 for for IN cord-300360-h6gr91eg 14 13 repurposing repurpose VBG cord-300360-h6gr91eg 14 14 metformin metformin NNP cord-300360-h6gr91eg 14 15 , , , cord-300360-h6gr91eg 14 16 a a DT cord-300360-h6gr91eg 14 17 well well RB cord-300360-h6gr91eg 14 18 - - HYPH cord-300360-h6gr91eg 14 19 known know VBN cord-300360-h6gr91eg 14 20 drug drug NN cord-300360-h6gr91eg 14 21 used use VBN cord-300360-h6gr91eg 14 22 for for IN cord-300360-h6gr91eg 14 23 the the DT cord-300360-h6gr91eg 14 24 treatment treatment NN cord-300360-h6gr91eg 14 25 of of IN cord-300360-h6gr91eg 14 26 diabetes diabetes NN cord-300360-h6gr91eg 14 27 Type type NN cord-300360-h6gr91eg 14 28 2 2 CD cord-300360-h6gr91eg 14 29 , , , cord-300360-h6gr91eg 14 30 for for IN cord-300360-h6gr91eg 14 31 the the DT cord-300360-h6gr91eg 14 32 prevention prevention NN cord-300360-h6gr91eg 14 33 and and CC cord-300360-h6gr91eg 14 34 treatment treatment NN cord-300360-h6gr91eg 14 35 of of IN cord-300360-h6gr91eg 14 36 cancer cancer NN cord-300360-h6gr91eg 14 37 [ [ -LRB- cord-300360-h6gr91eg 14 38 4 4 CD cord-300360-h6gr91eg 14 39 ] ] -RRB- cord-300360-h6gr91eg 14 40 . . . cord-300360-h6gr91eg 15 1 There there EX cord-300360-h6gr91eg 15 2 have have VBP cord-300360-h6gr91eg 15 3 also also RB cord-300360-h6gr91eg 15 4 been be VBN cord-300360-h6gr91eg 15 5 attempts attempt NNS cord-300360-h6gr91eg 15 6 to to TO cord-300360-h6gr91eg 15 7 repurpose repurpose VB cord-300360-h6gr91eg 15 8 metformin metformin NNP cord-300360-h6gr91eg 15 9 for for IN cord-300360-h6gr91eg 15 10 cardiovascular cardiovascular JJ cord-300360-h6gr91eg 15 11 diseases disease NNS cord-300360-h6gr91eg 15 12 [ [ -LRB- cord-300360-h6gr91eg 15 13 5 5 CD cord-300360-h6gr91eg 15 14 ] ] -RRB- cord-300360-h6gr91eg 15 15 , , , cord-300360-h6gr91eg 15 16 and and CC cord-300360-h6gr91eg 15 17 even even RB cord-300360-h6gr91eg 15 18 for for IN cord-300360-h6gr91eg 15 19 bacterial bacterial JJ cord-300360-h6gr91eg 15 20 infections infection NNS cord-300360-h6gr91eg 15 21 [ [ -LRB- cord-300360-h6gr91eg 15 22 6 6 CD cord-300360-h6gr91eg 15 23 ] ] -RRB- cord-300360-h6gr91eg 15 24 . . . cord-300360-h6gr91eg 16 1 As as IN cord-300360-h6gr91eg 16 2 mentioned mention VBN cord-300360-h6gr91eg 16 3 , , , cord-300360-h6gr91eg 16 4 a a DT cord-300360-h6gr91eg 16 5 number number NN cord-300360-h6gr91eg 16 6 of of IN cord-300360-h6gr91eg 16 7 drugs drug NNS cord-300360-h6gr91eg 16 8 are be VBP cord-300360-h6gr91eg 16 9 currently currently RB cord-300360-h6gr91eg 16 10 being be VBG cord-300360-h6gr91eg 16 11 studied study VBN cord-300360-h6gr91eg 16 12 for for IN cord-300360-h6gr91eg 16 13 their -PRON- PRP$ cord-300360-h6gr91eg 16 14 ability ability NN cord-300360-h6gr91eg 16 15 to to TO cord-300360-h6gr91eg 16 16 be be VB cord-300360-h6gr91eg 16 17 repurposed repurpose VBN cord-300360-h6gr91eg 16 18 as as IN cord-300360-h6gr91eg 16 19 a a DT cord-300360-h6gr91eg 16 20 treatment treatment NN cord-300360-h6gr91eg 16 21 for for IN cord-300360-h6gr91eg 16 22 COVID-19 COVID-19 NNP cord-300360-h6gr91eg 16 23 ( ( -LRB- cord-300360-h6gr91eg 16 24 chloroquine chloroquine NN cord-300360-h6gr91eg 16 25 , , , cord-300360-h6gr91eg 16 26 azithromycin azithromycin NNP cord-300360-h6gr91eg 16 27 , , , cord-300360-h6gr91eg 16 28 lopinavir lopinavir NNS cord-300360-h6gr91eg 16 29 - - HYPH cord-300360-h6gr91eg 16 30 ritonavir ritonavir NNP cord-300360-h6gr91eg 16 31 ) ) -RRB- cord-300360-h6gr91eg 16 32 . . . cord-300360-h6gr91eg 17 1 These these DT cord-300360-h6gr91eg 17 2 drugs drug NNS cord-300360-h6gr91eg 17 3 may may MD cord-300360-h6gr91eg 17 4 cause cause VB cord-300360-h6gr91eg 17 5 significant significant JJ cord-300360-h6gr91eg 17 6 side side NN cord-300360-h6gr91eg 17 7 effects effect NNS cord-300360-h6gr91eg 17 8 , , , cord-300360-h6gr91eg 17 9 such such JJ cord-300360-h6gr91eg 17 10 as as IN cord-300360-h6gr91eg 17 11 cardiac cardiac JJ cord-300360-h6gr91eg 17 12 and and CC cord-300360-h6gr91eg 17 13 hepatic hepatic JJ cord-300360-h6gr91eg 17 14 toxicity toxicity NN cord-300360-h6gr91eg 17 15 , , , cord-300360-h6gr91eg 17 16 pancreatitis pancreatitis NN cord-300360-h6gr91eg 17 17 , , , cord-300360-h6gr91eg 17 18 bone bone NN cord-300360-h6gr91eg 17 19 marrow marrow NN cord-300360-h6gr91eg 17 20 toxicity toxicity NN cord-300360-h6gr91eg 17 21 , , , cord-300360-h6gr91eg 17 22 etc etc FW cord-300360-h6gr91eg 17 23 . . FW cord-300360-h6gr91eg 17 24 , , , cord-300360-h6gr91eg 17 25 yet yet CC cord-300360-h6gr91eg 17 26 their -PRON- PRP$ cord-300360-h6gr91eg 17 27 clinical clinical JJ cord-300360-h6gr91eg 17 28 efficacy efficacy NN cord-300360-h6gr91eg 17 29 has have VBZ cord-300360-h6gr91eg 17 30 not not RB cord-300360-h6gr91eg 17 31 been be VBN cord-300360-h6gr91eg 17 32 proven prove VBN cord-300360-h6gr91eg 17 33 so so RB cord-300360-h6gr91eg 17 34 far far RB cord-300360-h6gr91eg 17 35 -no -no : cord-300360-h6gr91eg 17 36 ' ' POS cord-300360-h6gr91eg 17 37 magic magic JJ cord-300360-h6gr91eg 17 38 pill pill NN cord-300360-h6gr91eg 17 39 ' ' '' cord-300360-h6gr91eg 17 40 is be VBZ cord-300360-h6gr91eg 17 41 currently currently RB cord-300360-h6gr91eg 17 42 available available JJ cord-300360-h6gr91eg 17 43 . . . cord-300360-h6gr91eg 18 1 Therefore therefore RB cord-300360-h6gr91eg 18 2 , , , cord-300360-h6gr91eg 18 3 there there EX cord-300360-h6gr91eg 18 4 is be VBZ cord-300360-h6gr91eg 18 5 an an DT cord-300360-h6gr91eg 18 6 urgent urgent JJ cord-300360-h6gr91eg 18 7 need need NN cord-300360-h6gr91eg 18 8 for for IN cord-300360-h6gr91eg 18 9 other other JJ cord-300360-h6gr91eg 18 10 agents agent NNS cord-300360-h6gr91eg 18 11 that that WDT cord-300360-h6gr91eg 18 12 could could MD cord-300360-h6gr91eg 18 13 be be VB cord-300360-h6gr91eg 18 14 repurposed repurpose VBN cord-300360-h6gr91eg 18 15 to to TO cord-300360-h6gr91eg 18 16 combat combat VB cord-300360-h6gr91eg 18 17 the the DT cord-300360-h6gr91eg 18 18 epidemic epidemic NN cord-300360-h6gr91eg 18 19 [ [ -LRB- cord-300360-h6gr91eg 18 20 7 7 CD cord-300360-h6gr91eg 18 21 ] ] -RRB- cord-300360-h6gr91eg 18 22 . . . cord-300360-h6gr91eg 19 1 The the DT cord-300360-h6gr91eg 19 2 present present JJ cord-300360-h6gr91eg 19 3 antibiotic antibiotic JJ cord-300360-h6gr91eg 19 4 crisis crisis NN cord-300360-h6gr91eg 19 5 has have VBZ cord-300360-h6gr91eg 19 6 greatly greatly RB cord-300360-h6gr91eg 19 7 ignited ignite VBN cord-300360-h6gr91eg 19 8 interest interest NN cord-300360-h6gr91eg 19 9 in in IN cord-300360-h6gr91eg 19 10 the the DT cord-300360-h6gr91eg 19 11 potential potential NN cord-300360-h6gr91eg 19 12 of of IN cord-300360-h6gr91eg 19 13 phages phage NNS cord-300360-h6gr91eg 19 14 in in IN cord-300360-h6gr91eg 19 15 treating treat VBG cord-300360-h6gr91eg 19 16 multidrug multidrug NN cord-300360-h6gr91eg 19 17 - - HYPH cord-300360-h6gr91eg 19 18 resistant resistant JJ cord-300360-h6gr91eg 19 19 bacterial bacterial JJ cord-300360-h6gr91eg 19 20 infections infection NNS cord-300360-h6gr91eg 19 21 with with IN cord-300360-h6gr91eg 19 22 the the DT cord-300360-h6gr91eg 19 23 aid aid NN cord-300360-h6gr91eg 19 24 of of IN cord-300360-h6gr91eg 19 25 phage phage NN cord-300360-h6gr91eg 19 26 therapy therapy NN cord-300360-h6gr91eg 19 27 . . . cord-300360-h6gr91eg 20 1 Hopefully hopefully RB cord-300360-h6gr91eg 20 2 , , , cord-300360-h6gr91eg 20 3 the the DT cord-300360-h6gr91eg 20 4 current current JJ cord-300360-h6gr91eg 20 5 trend trend NN cord-300360-h6gr91eg 20 6 toward toward IN cord-300360-h6gr91eg 20 7 a a DT cord-300360-h6gr91eg 20 8 personalized personalized JJ cord-300360-h6gr91eg 20 9 medicine medicine NN cord-300360-h6gr91eg 20 10 may may MD cord-300360-h6gr91eg 20 11 help help VB cord-300360-h6gr91eg 20 12 to to TO cord-300360-h6gr91eg 20 13 introduce introduce VB cord-300360-h6gr91eg 20 14 the the DT cord-300360-h6gr91eg 20 15 therapy therapy NN cord-300360-h6gr91eg 20 16 in in IN cord-300360-h6gr91eg 20 17 modern modern JJ cord-300360-h6gr91eg 20 18 clinical clinical JJ cord-300360-h6gr91eg 20 19 medicine medicine NN cord-300360-h6gr91eg 20 20 [ [ -LRB- cord-300360-h6gr91eg 20 21 8 8 CD cord-300360-h6gr91eg 20 22 ] ] -RRB- cord-300360-h6gr91eg 20 23 . . . cord-300360-h6gr91eg 21 1 On on IN cord-300360-h6gr91eg 21 2 the the DT cord-300360-h6gr91eg 21 3 other other JJ cord-300360-h6gr91eg 21 4 hand hand NN cord-300360-h6gr91eg 21 5 , , , cord-300360-h6gr91eg 21 6 recent recent JJ cord-300360-h6gr91eg 21 7 progress progress NN cord-300360-h6gr91eg 21 8 in in IN cord-300360-h6gr91eg 21 9 our -PRON- PRP$ cord-300360-h6gr91eg 21 10 understanding understanding NN cord-300360-h6gr91eg 21 11 of of IN cord-300360-h6gr91eg 21 12 phage phage NN cord-300360-h6gr91eg 21 13 immunobiology immunobiology NN cord-300360-h6gr91eg 21 14 opens open VBZ cord-300360-h6gr91eg 21 15 perspectives perspective NNS cord-300360-h6gr91eg 21 16 for for IN cord-300360-h6gr91eg 21 17 the the DT cord-300360-h6gr91eg 21 18 repurposing repurposing NN cord-300360-h6gr91eg 21 19 of of IN cord-300360-h6gr91eg 21 20 phage phage NN cord-300360-h6gr91eg 21 21 therapy therapy NN cord-300360-h6gr91eg 21 22 to to IN cord-300360-h6gr91eg 21 23 clinical clinical JJ cord-300360-h6gr91eg 21 24 indications indication NNS cord-300360-h6gr91eg 21 25 other other JJ cord-300360-h6gr91eg 21 26 than than IN cord-300360-h6gr91eg 21 27 bacterial bacterial JJ cord-300360-h6gr91eg 21 28 infections infection NNS cord-300360-h6gr91eg 21 29 alone alone RB cord-300360-h6gr91eg 21 30 . . . cord-300360-h6gr91eg 22 1 There there EX cord-300360-h6gr91eg 22 2 are be VBP cord-300360-h6gr91eg 22 3 data datum NNS cord-300360-h6gr91eg 22 4 suggesting suggest VBG cord-300360-h6gr91eg 22 5 that that IN cord-300360-h6gr91eg 22 6 such such JJ cord-300360-h6gr91eg 22 7 indications indication NNS cord-300360-h6gr91eg 22 8 could could MD cord-300360-h6gr91eg 22 9 also also RB cord-300360-h6gr91eg 22 10 include include VB cord-300360-h6gr91eg 22 11 viral viral JJ cord-300360-h6gr91eg 22 12 infections infection NNS cord-300360-h6gr91eg 22 13 , , , cord-300360-h6gr91eg 22 14 possibly possibly RB cord-300360-h6gr91eg 22 15 including include VBG cord-300360-h6gr91eg 22 16 COVID-19 covid-19 VB cord-300360-h6gr91eg 22 17 . . . cord-300360-h6gr91eg 23 1 In in IN cord-300360-h6gr91eg 23 2 2005 2005 CD cord-300360-h6gr91eg 23 3 we -PRON- PRP cord-300360-h6gr91eg 23 4 published publish VBD cord-300360-h6gr91eg 23 5 a a DT cord-300360-h6gr91eg 23 6 short short JJ cord-300360-h6gr91eg 23 7 review review NN cord-300360-h6gr91eg 23 8 summarizing summarize VBG cord-300360-h6gr91eg 23 9 available available JJ cord-300360-h6gr91eg 23 10 historical historical JJ cord-300360-h6gr91eg 23 11 data datum NNS cord-300360-h6gr91eg 23 12 strongly strongly RB cord-300360-h6gr91eg 23 13 suggesting suggest VBG cord-300360-h6gr91eg 23 14 that that IN cord-300360-h6gr91eg 23 15 phages phage NNS cord-300360-h6gr91eg 23 16 , , , cord-300360-h6gr91eg 23 17 both both CC cord-300360-h6gr91eg 23 18 in in IN cord-300360-h6gr91eg 23 19 vitro vitro FW cord-300360-h6gr91eg 23 20 and and CC cord-300360-h6gr91eg 23 21 in in IN cord-300360-h6gr91eg 23 22 vivo vivo NNP cord-300360-h6gr91eg 23 23 , , , cord-300360-h6gr91eg 23 24 may may MD cord-300360-h6gr91eg 23 25 interfere interfere VB cord-300360-h6gr91eg 23 26 with with IN cord-300360-h6gr91eg 23 27 eukaryotic eukaryotic JJ cord-300360-h6gr91eg 23 28 viruses virus NNS cord-300360-h6gr91eg 23 29 . . . cord-300360-h6gr91eg 24 1 These these DT cord-300360-h6gr91eg 24 2 studies study NNS cord-300360-h6gr91eg 24 3 were be VBD cord-300360-h6gr91eg 24 4 initiated initiate VBN cord-300360-h6gr91eg 24 5 some some DT cord-300360-h6gr91eg 24 6 half half PDT cord-300360-h6gr91eg 24 7 a a DT cord-300360-h6gr91eg 24 8 century century NN cord-300360-h6gr91eg 24 9 ago ago RB cord-300360-h6gr91eg 24 10 and and CC cord-300360-h6gr91eg 24 11 pointed point VBD cord-300360-h6gr91eg 24 12 to to IN cord-300360-h6gr91eg 24 13 antiviral antiviral JJ cord-300360-h6gr91eg 24 14 effects effect NNS cord-300360-h6gr91eg 24 15 of of IN cord-300360-h6gr91eg 24 16 intact intact JJ cord-300360-h6gr91eg 24 17 phages phage NNS cord-300360-h6gr91eg 24 18 , , , cord-300360-h6gr91eg 24 19 phage phage NN cord-300360-h6gr91eg 24 20 lysates lysate NNS cord-300360-h6gr91eg 24 21 , , , cord-300360-h6gr91eg 24 22 as as RB cord-300360-h6gr91eg 24 23 well well RB cord-300360-h6gr91eg 24 24 as as IN cord-300360-h6gr91eg 24 25 phage phage NN cord-300360-h6gr91eg 24 26 - - HYPH cord-300360-h6gr91eg 24 27 derived derive VBN cord-300360-h6gr91eg 24 28 nucleid nucleid NNP cord-300360-h6gr91eg 24 29 acids acid NNS cord-300360-h6gr91eg 24 30 . . . cord-300360-h6gr91eg 25 1 Such such JJ cord-300360-h6gr91eg 25 2 antiviral antiviral JJ cord-300360-h6gr91eg 25 3 activities activity NNS cord-300360-h6gr91eg 25 4 of of IN cord-300360-h6gr91eg 25 5 phages phage NNS cord-300360-h6gr91eg 25 6 could could MD cord-300360-h6gr91eg 25 7 depend depend VB cord-300360-h6gr91eg 25 8 on on IN cord-300360-h6gr91eg 25 9 phage phage NN cord-300360-h6gr91eg 25 10 - - HYPH cord-300360-h6gr91eg 25 11 induced induce VBN cord-300360-h6gr91eg 25 12 inteferon inteferon NNP cord-300360-h6gr91eg 25 13 production production NN cord-300360-h6gr91eg 25 14 , , , cord-300360-h6gr91eg 25 15 competition competition NN cord-300360-h6gr91eg 25 16 of of IN cord-300360-h6gr91eg 25 17 phages phage NNS cord-300360-h6gr91eg 25 18 and and CC cord-300360-h6gr91eg 25 19 eukaryotic eukaryotic JJ cord-300360-h6gr91eg 25 20 viruses virus NNS cord-300360-h6gr91eg 25 21 for for IN cord-300360-h6gr91eg 25 22 the the DT cord-300360-h6gr91eg 25 23 same same JJ cord-300360-h6gr91eg 25 24 cellular cellular JJ cord-300360-h6gr91eg 25 25 receptors receptor NNS cord-300360-h6gr91eg 25 26 , , , cord-300360-h6gr91eg 25 27 as as RB cord-300360-h6gr91eg 25 28 well well RB cord-300360-h6gr91eg 25 29 as as IN cord-300360-h6gr91eg 25 30 induction induction NN cord-300360-h6gr91eg 25 31 of of IN cord-300360-h6gr91eg 25 32 antiviral antiviral JJ cord-300360-h6gr91eg 25 33 antibodies antibody NNS cord-300360-h6gr91eg 25 34 cross cross VBP cord-300360-h6gr91eg 25 35 - - NN cord-300360-h6gr91eg 25 36 reacting react VBG cord-300360-h6gr91eg 25 37 with with IN cord-300360-h6gr91eg 25 38 pathogenic pathogenic JJ cord-300360-h6gr91eg 25 39 viruses virus NNS cord-300360-h6gr91eg 25 40 ( ( -LRB- cord-300360-h6gr91eg 25 41 phage phage NN cord-300360-h6gr91eg 25 42 vaccines vaccine NNS cord-300360-h6gr91eg 25 43 ) ) -RRB- cord-300360-h6gr91eg 25 44 . . . cord-300360-h6gr91eg 26 1 In in IN cord-300360-h6gr91eg 26 2 addition addition NN cord-300360-h6gr91eg 26 3 , , , cord-300360-h6gr91eg 26 4 phage phage NN cord-300360-h6gr91eg 26 5 - - HYPH cord-300360-h6gr91eg 26 6 mediated mediate VBN cord-300360-h6gr91eg 26 7 inhibition inhibition NN cord-300360-h6gr91eg 26 8 of of IN cord-300360-h6gr91eg 26 9 other other JJ cord-300360-h6gr91eg 26 10 phenomena phenomenon NNS cord-300360-h6gr91eg 26 11 relevant relevant JJ cord-300360-h6gr91eg 26 12 in in IN cord-300360-h6gr91eg 26 13 virus virus NN cord-300360-h6gr91eg 26 14 - - HYPH cord-300360-h6gr91eg 26 15 dependent dependent JJ cord-300360-h6gr91eg 26 16 pathology pathology NN cord-300360-h6gr91eg 26 17 may may MD cord-300360-h6gr91eg 26 18 also also RB cord-300360-h6gr91eg 26 19 be be VB cord-300360-h6gr91eg 26 20 involved involve VBN cord-300360-h6gr91eg 26 21 [ [ -LRB- cord-300360-h6gr91eg 26 22 9 9 CD cord-300360-h6gr91eg 26 23 ] ] -RRB- cord-300360-h6gr91eg 26 24 . . . cord-300360-h6gr91eg 27 1 The the DT cord-300360-h6gr91eg 27 2 results result NNS cord-300360-h6gr91eg 27 3 of of IN cord-300360-h6gr91eg 27 4 research research NN cord-300360-h6gr91eg 27 5 carried carry VBN cord-300360-h6gr91eg 27 6 out out RP cord-300360-h6gr91eg 27 7 in in IN cord-300360-h6gr91eg 27 8 the the DT cord-300360-h6gr91eg 27 9 following follow VBG cord-300360-h6gr91eg 27 10 15 15 CD cord-300360-h6gr91eg 27 11 years year NNS cord-300360-h6gr91eg 27 12 support support VBP cord-300360-h6gr91eg 27 13 the the DT cord-300360-h6gr91eg 27 14 assumption assumption NN cord-300360-h6gr91eg 27 15 that that IN cord-300360-h6gr91eg 27 16 studies study NNS cord-300360-h6gr91eg 27 17 focusing focus VBG cord-300360-h6gr91eg 27 18 on on IN cord-300360-h6gr91eg 27 19 repurposing repurpose VBG cord-300360-h6gr91eg 27 20 phage phage NN cord-300360-h6gr91eg 27 21 therapy therapy NN cord-300360-h6gr91eg 27 22 at at RB cord-300360-h6gr91eg 27 23 least least JJS cord-300360-h6gr91eg 27 24 as as IN cord-300360-h6gr91eg 27 25 an an DT cord-300360-h6gr91eg 27 26 adjunct adjunct JJ cord-300360-h6gr91eg 27 27 therapy therapy NN cord-300360-h6gr91eg 27 28 for for IN cord-300360-h6gr91eg 27 29 viral viral JJ cord-300360-h6gr91eg 27 30 infections infection NNS cord-300360-h6gr91eg 27 31 , , , cord-300360-h6gr91eg 27 32 are be VBP cord-300360-h6gr91eg 27 33 warranted warrant VBN cord-300360-h6gr91eg 27 34 . . . cord-300360-h6gr91eg 28 1 We -PRON- PRP cord-300360-h6gr91eg 28 2 demonstrated demonstrate VBD cord-300360-h6gr91eg 28 3 protective protective JJ cord-300360-h6gr91eg 28 4 activity activity NN cord-300360-h6gr91eg 28 5 of of IN cord-300360-h6gr91eg 28 6 the the DT cord-300360-h6gr91eg 28 7 T4 T4 NNP cord-300360-h6gr91eg 28 8 phage phage NN cord-300360-h6gr91eg 28 9 on on IN cord-300360-h6gr91eg 28 10 the the DT cord-300360-h6gr91eg 28 11 survival survival NN cord-300360-h6gr91eg 28 12 of of IN cord-300360-h6gr91eg 28 13 human human JJ cord-300360-h6gr91eg 28 14 lung lung NN cord-300360-h6gr91eg 28 15 epithelial epithelial NN cord-300360-h6gr91eg 28 16 cells cell NNS cord-300360-h6gr91eg 28 17 infected infect VBN cord-300360-h6gr91eg 28 18 with with IN cord-300360-h6gr91eg 28 19 human human JJ cord-300360-h6gr91eg 28 20 Adv Adv NNP cord-300360-h6gr91eg 28 21 when when WRB cord-300360-h6gr91eg 28 22 the the DT cord-300360-h6gr91eg 28 23 phage phage NN cord-300360-h6gr91eg 28 24 was be VBD cord-300360-h6gr91eg 28 25 added add VBN cord-300360-h6gr91eg 28 26 before before IN cord-300360-h6gr91eg 28 27 or or CC cord-300360-h6gr91eg 28 28 during during IN cord-300360-h6gr91eg 28 29 the the DT cord-300360-h6gr91eg 28 30 entire entire JJ cord-300360-h6gr91eg 28 31 time time NN cord-300360-h6gr91eg 28 32 of of IN cord-300360-h6gr91eg 28 33 Adv Adv NNP cord-300360-h6gr91eg 28 34 infection infection NN cord-300360-h6gr91eg 28 35 ; ; : cord-300360-h6gr91eg 28 36 preincubation preincubation NN cord-300360-h6gr91eg 28 37 with with IN cord-300360-h6gr91eg 28 38 the the DT cord-300360-h6gr91eg 28 39 phage phage NN cord-300360-h6gr91eg 28 40 was be VBD cord-300360-h6gr91eg 28 41 also also RB cord-300360-h6gr91eg 28 42 protective protective JJ cord-300360-h6gr91eg 28 43 [ [ -LRB- cord-300360-h6gr91eg 28 44 10 10 CD cord-300360-h6gr91eg 28 45 ] ] -RRB- cord-300360-h6gr91eg 28 46 . . . cord-300360-h6gr91eg 29 1 Interestingly interestingly RB cord-300360-h6gr91eg 29 2 , , , cord-300360-h6gr91eg 29 3 while while IN cord-300360-h6gr91eg 29 4 SARS SARS NNP cord-300360-h6gr91eg 29 5 - - HYPH cord-300360-h6gr91eg 29 6 CoV CoV NNP cord-300360-h6gr91eg 29 7 and and CC cord-300360-h6gr91eg 29 8 SARS SARS NNP cord-300360-h6gr91eg 29 9 - - HYPH cord-300360-h6gr91eg 29 10 CoV-2 CoV-2 NNP cord-300360-h6gr91eg 29 11 are be VBP cord-300360-h6gr91eg 29 12 known know VBN cord-300360-h6gr91eg 29 13 to to TO cord-300360-h6gr91eg 29 14 induce induce VB cord-300360-h6gr91eg 29 15 apoptosis apoptosis NN cord-300360-h6gr91eg 29 16 and and CC cord-300360-h6gr91eg 29 17 resulting result VBG cord-300360-h6gr91eg 29 18 lymphocytopenia lymphocytopenia NNP cord-300360-h6gr91eg 29 19 is be VBZ cord-300360-h6gr91eg 29 20 a a DT cord-300360-h6gr91eg 29 21 common common JJ cord-300360-h6gr91eg 29 22 laboratory laboratory NN cord-300360-h6gr91eg 29 23 finding finding NN cord-300360-h6gr91eg 29 24 ( ( -LRB- cord-300360-h6gr91eg 30 1 > > XX cord-300360-h6gr91eg 30 2 60 60 CD cord-300360-h6gr91eg 30 3 of of IN cord-300360-h6gr91eg 30 4 patients patient NNS cord-300360-h6gr91eg 30 5 and and CC cord-300360-h6gr91eg 30 6 > > SYM cord-300360-h6gr91eg 30 7 80 80 CD cord-300360-h6gr91eg 30 8 % % NN cord-300360-h6gr91eg 30 9 in in IN cord-300360-h6gr91eg 30 10 the the DT cord-300360-h6gr91eg 30 11 dead dead JJ cord-300360-h6gr91eg 30 12 patients patient NNS cord-300360-h6gr91eg 30 13 ) ) -RRB- cord-300360-h6gr91eg 31 1 [ [ -LRB- cord-300360-h6gr91eg 31 2 11 11 CD cord-300360-h6gr91eg 31 3 , , , cord-300360-h6gr91eg 31 4 12 12 CD cord-300360-h6gr91eg 31 5 ] ] -RRB- cord-300360-h6gr91eg 31 6 , , , cord-300360-h6gr91eg 31 7 apoptosis apoptosis NN cord-300360-h6gr91eg 31 8 is be VBZ cord-300360-h6gr91eg 31 9 reduced reduce VBN cord-300360-h6gr91eg 31 10 in in IN cord-300360-h6gr91eg 31 11 airway airway NN cord-300360-h6gr91eg 31 12 epithelial epithelial JJ cord-300360-h6gr91eg 31 13 cells cell NNS cord-300360-h6gr91eg 31 14 harvested harvest VBN cord-300360-h6gr91eg 31 15 from from IN cord-300360-h6gr91eg 31 16 the the DT cord-300360-h6gr91eg 31 17 human human JJ cord-300360-h6gr91eg 31 18 bronchi bronchi NN cord-300360-h6gr91eg 31 19 and and CC cord-300360-h6gr91eg 31 20 cultured culture VBN cord-300360-h6gr91eg 31 21 with with IN cord-300360-h6gr91eg 31 22 phages phage NNS cord-300360-h6gr91eg 31 23 in in IN cord-300360-h6gr91eg 31 24 vitro vitro FW cord-300360-h6gr91eg 31 25 [ [ -LRB- cord-300360-h6gr91eg 31 26 13 13 CD cord-300360-h6gr91eg 31 27 ] ] -RRB- cord-300360-h6gr91eg 31 28 . . . cord-300360-h6gr91eg 32 1 Furthermore furthermore RB cord-300360-h6gr91eg 32 2 , , , cord-300360-h6gr91eg 32 3 both both CC cord-300360-h6gr91eg 32 4 T4 T4 NNP cord-300360-h6gr91eg 32 5 and and CC cord-300360-h6gr91eg 32 6 A3 A3 NNP cord-300360-h6gr91eg 32 7 / / SYM cord-300360-h6gr91eg 32 8 R r NN cord-300360-h6gr91eg 32 9 ( ( -LRB- cord-300360-h6gr91eg 32 10 staphylococcal staphylococcal JJ cord-300360-h6gr91eg 32 11 phage phage NN cord-300360-h6gr91eg 32 12 ) ) -RRB- cord-300360-h6gr91eg 32 13 preparations preparation NNS cord-300360-h6gr91eg 32 14 significantly significantly RB cord-300360-h6gr91eg 32 15 reduce reduce VBP cord-300360-h6gr91eg 32 16 the the DT cord-300360-h6gr91eg 32 17 percentage percentage NN cord-300360-h6gr91eg 32 18 of of IN cord-300360-h6gr91eg 32 19 DEC-205 DEC-205 NNP cord-300360-h6gr91eg 32 20 + + CC cord-300360-h6gr91eg 32 21 human human JJ cord-300360-h6gr91eg 32 22 myeloid myeloid NN cord-300360-h6gr91eg 32 23 cells cell NNS cord-300360-h6gr91eg 32 24 ( ( -LRB- cord-300360-h6gr91eg 32 25 lectin lectin NN cord-300360-h6gr91eg 32 26 receptor receptor NN cord-300360-h6gr91eg 32 27 recognizing recognize VBG cord-300360-h6gr91eg 32 28 ligands ligand NNS cord-300360-h6gr91eg 32 29 expressed express VBN cord-300360-h6gr91eg 32 30 during during IN cord-300360-h6gr91eg 32 31 apoptosis apoptosis NN cord-300360-h6gr91eg 32 32 and and CC cord-300360-h6gr91eg 32 33 necrosis necrosis NN cord-300360-h6gr91eg 32 34 of of IN cord-300360-h6gr91eg 32 35 different different JJ cord-300360-h6gr91eg 32 36 cell cell NN cord-300360-h6gr91eg 32 37 populations population NNS cord-300360-h6gr91eg 32 38 ) ) -RRB- cord-300360-h6gr91eg 32 39 [ [ -LRB- cord-300360-h6gr91eg 32 40 14 14 CD cord-300360-h6gr91eg 32 41 ] ] -RRB- cord-300360-h6gr91eg 32 42 . . . cord-300360-h6gr91eg 33 1 Both both DT cord-300360-h6gr91eg 33 2 T4 T4 NNP cord-300360-h6gr91eg 33 3 and and CC cord-300360-h6gr91eg 33 4 A5/80 A5/80 NNP cord-300360-h6gr91eg 33 5 phages phage NNS cord-300360-h6gr91eg 33 6 may may MD cord-300360-h6gr91eg 33 7 cause cause VB cord-300360-h6gr91eg 33 8 a a DT cord-300360-h6gr91eg 33 9 high high JJ cord-300360-h6gr91eg 33 10 overexpression overexpression NN cord-300360-h6gr91eg 33 11 of of IN cord-300360-h6gr91eg 33 12 the the DT cord-300360-h6gr91eg 33 13 HSA1 HSA1 NNP cord-300360-h6gr91eg 33 14 gene gene NN cord-300360-h6gr91eg 33 15 coding code VBG cord-300360-h6gr91eg 33 16 a a DT cord-300360-h6gr91eg 33 17 heat heat NN cord-300360-h6gr91eg 33 18 shock shock NN cord-300360-h6gr91eg 33 19 protein protein NN cord-300360-h6gr91eg 33 20 , , , cord-300360-h6gr91eg 33 21 Hsp70 Hsp70 NNP cord-300360-h6gr91eg 33 22 , , , cord-300360-h6gr91eg 33 23 in in IN cord-300360-h6gr91eg 33 24 human human JJ cord-300360-h6gr91eg 33 25 alveolar alveolar NN cord-300360-h6gr91eg 33 26 cells cell NNS cord-300360-h6gr91eg 33 27 [ [ -LRB- cord-300360-h6gr91eg 33 28 15 15 CD cord-300360-h6gr91eg 33 29 ] ] -RRB- cord-300360-h6gr91eg 33 30 . . . cord-300360-h6gr91eg 34 1 This this DT cord-300360-h6gr91eg 34 2 well well RB cord-300360-h6gr91eg 34 3 - - HYPH cord-300360-h6gr91eg 34 4 known know VBN cord-300360-h6gr91eg 34 5 cellular cellular JJ cord-300360-h6gr91eg 34 6 chaperone chaperone NN cord-300360-h6gr91eg 34 7 may may MD cord-300360-h6gr91eg 34 8 protect protect VB cord-300360-h6gr91eg 34 9 cells cell NNS cord-300360-h6gr91eg 34 10 undergoing undergo VBG cord-300360-h6gr91eg 34 11 transcytosis transcytosis NN cord-300360-h6gr91eg 34 12 from from IN cord-300360-h6gr91eg 34 13 potential potential JJ cord-300360-h6gr91eg 34 14 injury injury NN cord-300360-h6gr91eg 34 15 by by IN cord-300360-h6gr91eg 34 16 cellular cellular JJ cord-300360-h6gr91eg 34 17 phages phage NNS cord-300360-h6gr91eg 34 18 [ [ -LRB- cord-300360-h6gr91eg 34 19 16 16 CD cord-300360-h6gr91eg 34 20 ] ] -RRB- cord-300360-h6gr91eg 34 21 . . . cord-300360-h6gr91eg 35 1 On on IN cord-300360-h6gr91eg 35 2 the the DT cord-300360-h6gr91eg 35 3 other other JJ cord-300360-h6gr91eg 35 4 hand hand NN cord-300360-h6gr91eg 35 5 , , , cord-300360-h6gr91eg 35 6 expression expression NN cord-300360-h6gr91eg 35 7 of of IN cord-300360-h6gr91eg 35 8 another another DT cord-300360-h6gr91eg 35 9 heat heat NN cord-300360-h6gr91eg 35 10 shock shock NN cord-300360-h6gr91eg 35 11 protein protein NN cord-300360-h6gr91eg 35 12 Hsp90 Hsp90 NNP cord-300360-h6gr91eg 35 13 , , , cord-300360-h6gr91eg 35 14 may may MD cord-300360-h6gr91eg 35 15 be be VB cord-300360-h6gr91eg 35 16 downregulated downregulate VBN cord-300360-h6gr91eg 35 17 by by IN cord-300360-h6gr91eg 35 18 T4 T4 NNP cord-300360-h6gr91eg 35 19 and and CC cord-300360-h6gr91eg 35 20 M13 M13 NNP cord-300360-h6gr91eg 35 21 phages phage NNS cord-300360-h6gr91eg 35 22 [ [ -LRB- cord-300360-h6gr91eg 35 23 17 17 CD cord-300360-h6gr91eg 35 24 ] ] -RRB- cord-300360-h6gr91eg 35 25 . . . cord-300360-h6gr91eg 36 1 Hsp90 Hsp90 NNP cord-300360-h6gr91eg 36 2 is be VBZ cord-300360-h6gr91eg 36 3 relevant relevant JJ cord-300360-h6gr91eg 36 4 for for IN cord-300360-h6gr91eg 36 5 the the DT cord-300360-h6gr91eg 36 6 life life NN cord-300360-h6gr91eg 36 7 cycle cycle NN cord-300360-h6gr91eg 36 8 of of IN cord-300360-h6gr91eg 36 9 viruses virus NNS cord-300360-h6gr91eg 36 10 and and CC cord-300360-h6gr91eg 36 11 its -PRON- PRP$ cord-300360-h6gr91eg 36 12 inhibitors inhibitor NNS cord-300360-h6gr91eg 36 13 may may MD cord-300360-h6gr91eg 36 14 have have VB cord-300360-h6gr91eg 36 15 antiviral antiviral JJ cord-300360-h6gr91eg 36 16 properties property NNS cord-300360-h6gr91eg 36 17 [ [ -LRB- cord-300360-h6gr91eg 36 18 18 18 CD cord-300360-h6gr91eg 36 19 , , , cord-300360-h6gr91eg 36 20 19 19 CD cord-300360-h6gr91eg 36 21 ] ] -RRB- cord-300360-h6gr91eg 36 22 . . . cord-300360-h6gr91eg 37 1 We -PRON- PRP cord-300360-h6gr91eg 37 2 hypothesized hypothesize VBD cord-300360-h6gr91eg 37 3 that that IN cord-300360-h6gr91eg 37 4 phages phage NNS cord-300360-h6gr91eg 37 5 present present JJ cord-300360-h6gr91eg 37 6 in in IN cord-300360-h6gr91eg 37 7 the the DT cord-300360-h6gr91eg 37 8 human human JJ cord-300360-h6gr91eg 37 9 body body NN cord-300360-h6gr91eg 37 10 may may MD cord-300360-h6gr91eg 37 11 transmigrate transmigrate VB cord-300360-h6gr91eg 37 12 from from IN cord-300360-h6gr91eg 37 13 the the DT cord-300360-h6gr91eg 37 14 gut gut NN cord-300360-h6gr91eg 37 15 and and CC cord-300360-h6gr91eg 37 16 mediate mediate VB cord-300360-h6gr91eg 37 17 immunomodulatory immunomodulatory JJ cord-300360-h6gr91eg 37 18 activities activity NNS cord-300360-h6gr91eg 37 19 at at IN cord-300360-h6gr91eg 37 20 different different JJ cord-300360-h6gr91eg 37 21 tissue tissue NN cord-300360-h6gr91eg 37 22 sites site NNS cord-300360-h6gr91eg 37 23 [ [ -LRB- cord-300360-h6gr91eg 37 24 20 20 CD cord-300360-h6gr91eg 37 25 ] ] -RRB- cord-300360-h6gr91eg 37 26 . . . cord-300360-h6gr91eg 38 1 This this DT cord-300360-h6gr91eg 38 2 hypothesis hypothesis NN cord-300360-h6gr91eg 38 3 has have VBZ cord-300360-h6gr91eg 38 4 been be VBN cord-300360-h6gr91eg 38 5 fully fully RB cord-300360-h6gr91eg 38 6 confirmed confirm VBN cord-300360-h6gr91eg 38 7 by by IN cord-300360-h6gr91eg 38 8 recent recent JJ cord-300360-h6gr91eg 38 9 studies study NNS cord-300360-h6gr91eg 38 10 that that WDT cord-300360-h6gr91eg 38 11 have have VBP cord-300360-h6gr91eg 38 12 revealed reveal VBN cord-300360-h6gr91eg 38 13 that that IN cord-300360-h6gr91eg 38 14 phages phage NNS cord-300360-h6gr91eg 38 15 present present JJ cord-300360-h6gr91eg 38 16 in in IN cord-300360-h6gr91eg 38 17 the the DT cord-300360-h6gr91eg 38 18 human human JJ cord-300360-h6gr91eg 38 19 body body NN cord-300360-h6gr91eg 38 20 may may MD cord-300360-h6gr91eg 38 21 penetrate penetrate VB cord-300360-h6gr91eg 38 22 epithelial epithelial JJ cord-300360-h6gr91eg 38 23 cell cell NN cord-300360-h6gr91eg 38 24 layers layer NNS cord-300360-h6gr91eg 38 25 from from IN cord-300360-h6gr91eg 38 26 gut gut NN cord-300360-h6gr91eg 38 27 , , , cord-300360-h6gr91eg 38 28 lung lung NN cord-300360-h6gr91eg 38 29 and and CC cord-300360-h6gr91eg 38 30 other other JJ cord-300360-h6gr91eg 38 31 organs organ NNS cord-300360-h6gr91eg 38 32 without without IN cord-300360-h6gr91eg 38 33 causing cause VBG cord-300360-h6gr91eg 38 34 any any DT cord-300360-h6gr91eg 38 35 harmful harmful JJ cord-300360-h6gr91eg 38 36 effects effect NNS cord-300360-h6gr91eg 38 37 . . . cord-300360-h6gr91eg 39 1 For for IN cord-300360-h6gr91eg 39 2 example example NN cord-300360-h6gr91eg 39 3 , , , cord-300360-h6gr91eg 39 4 T4 T4 NNP cord-300360-h6gr91eg 39 5 phage phage NN cord-300360-h6gr91eg 39 6 can can MD cord-300360-h6gr91eg 39 7 transcytose transcytose VB cord-300360-h6gr91eg 39 8 across across IN cord-300360-h6gr91eg 39 9 epithelial epithelial JJ cord-300360-h6gr91eg 39 10 cells cell NNS cord-300360-h6gr91eg 39 11 and and CC cord-300360-h6gr91eg 39 12 this this DT cord-300360-h6gr91eg 39 13 phenomenon phenomenon NN cord-300360-h6gr91eg 39 14 encompasses encompass VBZ cord-300360-h6gr91eg 39 15 diverse diverse JJ cord-300360-h6gr91eg 39 16 phages phage NNS cord-300360-h6gr91eg 39 17 from from IN cord-300360-h6gr91eg 39 18 major major JJ cord-300360-h6gr91eg 39 19 morphotypes morphotype NNS cord-300360-h6gr91eg 39 20 and and CC cord-300360-h6gr91eg 39 21 Gram gram NN cord-300360-h6gr91eg 39 22 - - HYPH cord-300360-h6gr91eg 39 23 positive positive JJ cord-300360-h6gr91eg 39 24 and and CC cord-300360-h6gr91eg 39 25 negative negative JJ cord-300360-h6gr91eg 39 26 hosts host NNS cord-300360-h6gr91eg 39 27 . . . cord-300360-h6gr91eg 40 1 The the DT cord-300360-h6gr91eg 40 2 average average JJ cord-300360-h6gr91eg 40 3 human human JJ cord-300360-h6gr91eg 40 4 body body NN cord-300360-h6gr91eg 40 5 transcytoses transcytoses NNP cord-300360-h6gr91eg 40 6 3.1×10 3.1×10 CD cord-300360-h6gr91eg 40 7 10 10 CD cord-300360-h6gr91eg 40 8 phages phage NNS cord-300360-h6gr91eg 40 9 per per IN cord-300360-h6gr91eg 40 10 day day NN cord-300360-h6gr91eg 41 1 and and CC cord-300360-h6gr91eg 41 2 it -PRON- PRP cord-300360-h6gr91eg 41 3 is be VBZ cord-300360-h6gr91eg 41 4 believed believe VBN cord-300360-h6gr91eg 41 5 that that IN cord-300360-h6gr91eg 41 6 this this DT cord-300360-h6gr91eg 41 7 continuous continuous JJ cord-300360-h6gr91eg 41 8 stream stream NN cord-300360-h6gr91eg 41 9 of of IN cord-300360-h6gr91eg 41 10 endogenous endogenous JJ cord-300360-h6gr91eg 41 11 phages phage NNS cord-300360-h6gr91eg 41 12 disseminating disseminate VBG cord-300360-h6gr91eg 41 13 through through IN cord-300360-h6gr91eg 41 14 the the DT cord-300360-h6gr91eg 41 15 blood blood NN cord-300360-h6gr91eg 41 16 and and CC cord-300360-h6gr91eg 41 17 organs organ NNS cord-300360-h6gr91eg 41 18 may may MD cord-300360-h6gr91eg 41 19 provide provide VB cord-300360-h6gr91eg 41 20 antimicrobial antimicrobial JJ cord-300360-h6gr91eg 41 21 defenses defense NNS cord-300360-h6gr91eg 41 22 [ [ -LRB- cord-300360-h6gr91eg 41 23 21 21 CD cord-300360-h6gr91eg 41 24 , , , cord-300360-h6gr91eg 41 25 22 22 CD cord-300360-h6gr91eg 41 26 ] ] -RRB- cord-300360-h6gr91eg 41 27 . . . cord-300360-h6gr91eg 42 1 Furthermore furthermore RB cord-300360-h6gr91eg 42 2 , , , cord-300360-h6gr91eg 42 3 a a DT cord-300360-h6gr91eg 42 4 comparable comparable JJ cord-300360-h6gr91eg 42 5 load load NN cord-300360-h6gr91eg 42 6 of of IN cord-300360-h6gr91eg 42 7 phages phage NNS cord-300360-h6gr91eg 42 8 may may MD cord-300360-h6gr91eg 42 9 be be VB cord-300360-h6gr91eg 42 10 infused infuse VBN cord-300360-h6gr91eg 42 11 to to IN cord-300360-h6gr91eg 42 12 patients patient NNS cord-300360-h6gr91eg 42 13 during during IN cord-300360-h6gr91eg 42 14 phage phage NN cord-300360-h6gr91eg 42 15 therapy therapy NN cord-300360-h6gr91eg 42 16 [ [ -LRB- cord-300360-h6gr91eg 42 17 23 23 CD cord-300360-h6gr91eg 42 18 ] ] -RRB- cord-300360-h6gr91eg 42 19 . . . cord-300360-h6gr91eg 43 1 Thus thus RB cord-300360-h6gr91eg 43 2 , , , cord-300360-h6gr91eg 43 3 phages phage NNS cord-300360-h6gr91eg 43 4 infused infuse VBN cord-300360-h6gr91eg 43 5 during during IN cord-300360-h6gr91eg 43 6 phage phage NN cord-300360-h6gr91eg 43 7 therapy therapy NN cord-300360-h6gr91eg 43 8 provide provide VBP cord-300360-h6gr91eg 43 9 significant significant JJ cord-300360-h6gr91eg 43 10 additional additional JJ cord-300360-h6gr91eg 43 11 loads load NNS cord-300360-h6gr91eg 43 12 of of IN cord-300360-h6gr91eg 43 13 circulating circulate VBG cord-300360-h6gr91eg 43 14 phages phage NNS cord-300360-h6gr91eg 43 15 , , , cord-300360-h6gr91eg 43 16 able able JJ cord-300360-h6gr91eg 43 17 to to TO cord-300360-h6gr91eg 43 18 permeate permeate VB cord-300360-h6gr91eg 43 19 epithelial epithelial JJ cord-300360-h6gr91eg 43 20 cells cell NNS cord-300360-h6gr91eg 43 21 in in IN cord-300360-h6gr91eg 43 22 a a DT cord-300360-h6gr91eg 43 23 process process NN cord-300360-h6gr91eg 43 24 described describe VBN cord-300360-h6gr91eg 43 25 by by IN cord-300360-h6gr91eg 43 26 Nguyen Nguyen NNP cord-300360-h6gr91eg 43 27 et et NNP cord-300360-h6gr91eg 43 28 al al NNP cord-300360-h6gr91eg 43 29 . . . cord-300360-h6gr91eg 44 1 [ [ -LRB- cord-300360-h6gr91eg 44 2 21 21 CD cord-300360-h6gr91eg 44 3 ] ] -RRB- cord-300360-h6gr91eg 44 4 . . . cord-300360-h6gr91eg 45 1 In in IN cord-300360-h6gr91eg 45 2 other other JJ cord-300360-h6gr91eg 45 3 words word NNS cord-300360-h6gr91eg 45 4 , , , cord-300360-h6gr91eg 45 5 an an DT cord-300360-h6gr91eg 45 6 increase increase NN cord-300360-h6gr91eg 45 7 in in IN cord-300360-h6gr91eg 45 8 phage phage NN cord-300360-h6gr91eg 45 9 transcytosis transcytosis NN cord-300360-h6gr91eg 45 10 by by IN cord-300360-h6gr91eg 45 11 epithelial epithelial JJ cord-300360-h6gr91eg 45 12 cells cell NNS cord-300360-h6gr91eg 45 13 caused cause VBN cord-300360-h6gr91eg 45 14 by by IN cord-300360-h6gr91eg 45 15 phage phage NN cord-300360-h6gr91eg 45 16 therapy therapy NN cord-300360-h6gr91eg 45 17 could could MD cord-300360-h6gr91eg 45 18 build build VB cord-300360-h6gr91eg 45 19 a a DT cord-300360-h6gr91eg 45 20 protective protective JJ cord-300360-h6gr91eg 45 21 barrier barrier NN cord-300360-h6gr91eg 45 22 to to IN cord-300360-h6gr91eg 45 23 eukaryotic eukaryotic JJ cord-300360-h6gr91eg 45 24 virus virus NN cord-300360-h6gr91eg 45 25 particles particle NNS cord-300360-h6gr91eg 45 26 . . . cord-300360-h6gr91eg 46 1 Since since IN cord-300360-h6gr91eg 46 2 lung lung NN cord-300360-h6gr91eg 46 3 epithelium epithelium NN cord-300360-h6gr91eg 46 4 is be VBZ cord-300360-h6gr91eg 46 5 also also RB cord-300360-h6gr91eg 46 6 engaged engage VBN cord-300360-h6gr91eg 46 7 in in IN cord-300360-h6gr91eg 46 8 transcytosis transcytosis NN cord-300360-h6gr91eg 46 9 of of IN cord-300360-h6gr91eg 46 10 phages phage NNS cord-300360-h6gr91eg 46 11 [ [ -LRB- cord-300360-h6gr91eg 46 12 21 21 CD cord-300360-h6gr91eg 46 13 ] ] -RRB- cord-300360-h6gr91eg 46 14 , , , cord-300360-h6gr91eg 46 15 this this DT cord-300360-h6gr91eg 46 16 phenomenon phenomenon NN cord-300360-h6gr91eg 46 17 could could MD cord-300360-h6gr91eg 46 18 play play VB cord-300360-h6gr91eg 46 19 some some DT cord-300360-h6gr91eg 46 20 role role NN cord-300360-h6gr91eg 46 21 in in IN cord-300360-h6gr91eg 46 22 protecting protect VBG cord-300360-h6gr91eg 46 23 those those DT cord-300360-h6gr91eg 46 24 cells cell NNS cord-300360-h6gr91eg 46 25 from from IN cord-300360-h6gr91eg 46 26 invasion invasion NN cord-300360-h6gr91eg 46 27 by by IN cord-300360-h6gr91eg 46 28 coronaviruses coronaviruse NNS cord-300360-h6gr91eg 46 29 . . . cord-300360-h6gr91eg 47 1 It -PRON- PRP cord-300360-h6gr91eg 47 2 was be VBD cord-300360-h6gr91eg 47 3 shown show VBN cord-300360-h6gr91eg 47 4 that that IN cord-300360-h6gr91eg 47 5 the the DT cord-300360-h6gr91eg 47 6 T4 T4 NNP cord-300360-h6gr91eg 47 7 phage phage NN cord-300360-h6gr91eg 47 8 inhibits inhibit VBZ cord-300360-h6gr91eg 47 9 adsorption adsorption NN cord-300360-h6gr91eg 47 10 of of IN cord-300360-h6gr91eg 47 11 human human JJ cord-300360-h6gr91eg 47 12 Adv Adv NNP cord-300360-h6gr91eg 47 13 to to IN cord-300360-h6gr91eg 47 14 human human JJ cord-300360-h6gr91eg 47 15 lung lung NN cord-300360-h6gr91eg 47 16 and and CC cord-300360-h6gr91eg 47 17 kidney kidney NN cord-300360-h6gr91eg 47 18 epithelial epithelial JJ cord-300360-h6gr91eg 47 19 cells cell NNS cord-300360-h6gr91eg 47 20 ; ; : cord-300360-h6gr91eg 47 21 moreover moreover RB cord-300360-h6gr91eg 47 22 , , , cord-300360-h6gr91eg 47 23 viral viral JJ cord-300360-h6gr91eg 47 24 replication replication NN cord-300360-h6gr91eg 47 25 was be VBD cord-300360-h6gr91eg 47 26 also also RB cord-300360-h6gr91eg 47 27 inhibited inhibit VBN cord-300360-h6gr91eg 47 28 [ [ -LRB- cord-300360-h6gr91eg 47 29 24 24 CD cord-300360-h6gr91eg 47 30 ] ] -RRB- cord-300360-h6gr91eg 47 31 . . . cord-300360-h6gr91eg 48 1 T4 T4 NNP cord-300360-h6gr91eg 48 2 phage phage NN cord-300360-h6gr91eg 48 3 could could MD cord-300360-h6gr91eg 48 4 also also RB cord-300360-h6gr91eg 48 5 impair impair VB cord-300360-h6gr91eg 48 6 CoV cov NN cord-300360-h6gr91eg 48 7 attachment attachment NN cord-300360-h6gr91eg 48 8 to to TO cord-300360-h6gr91eg 48 9 target target VB cord-300360-h6gr91eg 48 10 cells cell NNS cord-300360-h6gr91eg 48 11 through through IN cord-300360-h6gr91eg 48 12 its -PRON- PRP$ cord-300360-h6gr91eg 48 13 KGD KGD NNP cord-300360-h6gr91eg 48 14 sequence sequence NN cord-300360-h6gr91eg 48 15 . . . cord-300360-h6gr91eg 49 1 This this DT cord-300360-h6gr91eg 49 2 integrin integrin JJ cord-300360-h6gr91eg 49 3 KGD kgd NN cord-300360-h6gr91eg 49 4 motif motif NN cord-300360-h6gr91eg 49 5 ( ( -LRB- cord-300360-h6gr91eg 49 6 Lys Lys NNP cord-300360-h6gr91eg 49 7 - - HYPH cord-300360-h6gr91eg 49 8 Gly Gly NNP cord-300360-h6gr91eg 49 9 - - HYPH cord-300360-h6gr91eg 49 10 Asp Asp NNP cord-300360-h6gr91eg 49 11 ) ) -RRB- cord-300360-h6gr91eg 49 12 present present JJ cord-300360-h6gr91eg 49 13 in in IN cord-300360-h6gr91eg 49 14 the the DT cord-300360-h6gr91eg 49 15 capsid capsid JJ cord-300360-h6gr91eg 49 16 protein protein NN cord-300360-h6gr91eg 49 17 of of IN cord-300360-h6gr91eg 49 18 the the DT cord-300360-h6gr91eg 49 19 T4 T4 NNP cord-300360-h6gr91eg 49 20 phage phage NN cord-300360-h6gr91eg 49 21 is be VBZ cord-300360-h6gr91eg 49 22 functional functional JJ cord-300360-h6gr91eg 49 23 and and CC cord-300360-h6gr91eg 49 24 may may MD cord-300360-h6gr91eg 49 25 mediate mediate VB cord-300360-h6gr91eg 49 26 interactions interaction NNS cord-300360-h6gr91eg 49 27 of of IN cord-300360-h6gr91eg 49 28 phage phage NN cord-300360-h6gr91eg 49 29 with with IN cord-300360-h6gr91eg 49 30 eukaryotic eukaryotic JJ cord-300360-h6gr91eg 49 31 cells cell NNS cord-300360-h6gr91eg 49 32 [ [ -LRB- cord-300360-h6gr91eg 49 33 16 16 CD cord-300360-h6gr91eg 49 34 ] ] -RRB- cord-300360-h6gr91eg 49 35 . . . cord-300360-h6gr91eg 50 1 KGD KGD NNP cord-300360-h6gr91eg 50 2 is be VBZ cord-300360-h6gr91eg 50 3 found find VBN cord-300360-h6gr91eg 50 4 prominently prominently RB cord-300360-h6gr91eg 50 5 on on IN cord-300360-h6gr91eg 50 6 gH gH NNP cord-300360-h6gr91eg 50 7 / / SYM cord-300360-h6gr91eg 50 8 gl gl NNP cord-300360-h6gr91eg 50 9 glycoprotein glycoprotein NN cord-300360-h6gr91eg 50 10 orchestrating orchestrate VBG cord-300360-h6gr91eg 50 11 infection infection NN cord-300360-h6gr91eg 50 12 of of IN cord-300360-h6gr91eg 50 13 EBV EBV NNP cord-300360-h6gr91eg 50 14 of of IN cord-300360-h6gr91eg 50 15 B b NN cord-300360-h6gr91eg 50 16 cells cell NNS cord-300360-h6gr91eg 50 17 and and CC cord-300360-h6gr91eg 50 18 epithelial epithelial JJ cord-300360-h6gr91eg 50 19 cells cell NNS cord-300360-h6gr91eg 50 20 , , , cord-300360-h6gr91eg 50 21 and and CC cord-300360-h6gr91eg 50 22 its -PRON- PRP$ cord-300360-h6gr91eg 50 23 inactivation inactivation NN cord-300360-h6gr91eg 50 24 downregulates downregulate VBZ cord-300360-h6gr91eg 50 25 EBV EBV NNP cord-300360-h6gr91eg 50 26 interaction interaction NN cord-300360-h6gr91eg 50 27 with with IN cord-300360-h6gr91eg 50 28 target target NN cord-300360-h6gr91eg 50 29 cells cell NNS cord-300360-h6gr91eg 50 30 [ [ -LRB- cord-300360-h6gr91eg 50 31 25 25 CD cord-300360-h6gr91eg 50 32 ] ] -RRB- cord-300360-h6gr91eg 50 33 . . . cord-300360-h6gr91eg 51 1 Therefore therefore RB cord-300360-h6gr91eg 51 2 , , , cord-300360-h6gr91eg 51 3 T4 T4 NNP cord-300360-h6gr91eg 51 4 could could MD cord-300360-h6gr91eg 51 5 interfere interfere VB cord-300360-h6gr91eg 51 6 with with IN cord-300360-h6gr91eg 51 7 EBV EBV NNP cord-300360-h6gr91eg 51 8 infection infection NN cord-300360-h6gr91eg 51 9 [ [ -LRB- cord-300360-h6gr91eg 51 10 26 26 CD cord-300360-h6gr91eg 51 11 ] ] -RRB- cord-300360-h6gr91eg 51 12 . . . cord-300360-h6gr91eg 52 1 Interestingly interestingly RB cord-300360-h6gr91eg 52 2 , , , cord-300360-h6gr91eg 52 3 this this DT cord-300360-h6gr91eg 52 4 amino amino NN cord-300360-h6gr91eg 52 5 acid acid NN cord-300360-h6gr91eg 52 6 sequence sequence NN cord-300360-h6gr91eg 52 7 is be VBZ cord-300360-h6gr91eg 52 8 conserved conserve VBN cord-300360-h6gr91eg 52 9 in in IN cord-300360-h6gr91eg 52 10 several several JJ cord-300360-h6gr91eg 52 11 coronaviruses coronaviruse NNS cord-300360-h6gr91eg 52 12 and and CC cord-300360-h6gr91eg 52 13 it -PRON- PRP cord-300360-h6gr91eg 52 14 is be VBZ cord-300360-h6gr91eg 52 15 also also RB cord-300360-h6gr91eg 52 16 displayed display VBN cord-300360-h6gr91eg 52 17 in in IN cord-300360-h6gr91eg 52 18 exposed expose VBN cord-300360-h6gr91eg 52 19 loop loop NN cord-300360-h6gr91eg 52 20 of of IN cord-300360-h6gr91eg 52 21 major major JJ cord-300360-h6gr91eg 52 22 structural structural JJ cord-300360-h6gr91eg 52 23 SARS SARS NNP cord-300360-h6gr91eg 52 24 - - HYPH cord-300360-h6gr91eg 52 25 CoV CoV NNP cord-300360-h6gr91eg 52 26 protein protein NN cord-300360-h6gr91eg 53 1 S. S. NNP cord-300360-h6gr91eg 53 2 Moreover moreover RB cord-300360-h6gr91eg 53 3 , , , cord-300360-h6gr91eg 53 4 the the DT cord-300360-h6gr91eg 53 5 same same JJ cord-300360-h6gr91eg 53 6 KGD KGD NNP cord-300360-h6gr91eg 53 7 sequence sequence NN cord-300360-h6gr91eg 53 8 is be VBZ cord-300360-h6gr91eg 53 9 also also RB cord-300360-h6gr91eg 53 10 expressed express VBN cord-300360-h6gr91eg 53 11 in in IN cord-300360-h6gr91eg 53 12 angiotensin angiotensin NN cord-300360-h6gr91eg 53 13 - - HYPH cord-300360-h6gr91eg 53 14 converting convert VBG cord-300360-h6gr91eg 53 15 enzyme enzyme NN cord-300360-h6gr91eg 53 16 2 2 CD cord-300360-h6gr91eg 53 17 molecule molecule NN cord-300360-h6gr91eg 53 18 , , , cord-300360-h6gr91eg 53 19 a a DT cord-300360-h6gr91eg 53 20 recognition recognition NN cord-300360-h6gr91eg 53 21 receptor receptor NN cord-300360-h6gr91eg 53 22 for for IN cord-300360-h6gr91eg 53 23 protein protein NN cord-300360-h6gr91eg 53 24 S S NNP cord-300360-h6gr91eg 53 25 , , , cord-300360-h6gr91eg 53 26 suggesting suggest VBG cord-300360-h6gr91eg 53 27 a a DT cord-300360-h6gr91eg 53 28 potential potential JJ cord-300360-h6gr91eg 53 29 inhibitory inhibitory JJ cord-300360-h6gr91eg 53 30 role role NN cord-300360-h6gr91eg 53 31 for for IN cord-300360-h6gr91eg 53 32 integrins integrin NNS cord-300360-h6gr91eg 53 33 in in IN cord-300360-h6gr91eg 53 34 the the DT cord-300360-h6gr91eg 53 35 receptor receptor NN cord-300360-h6gr91eg 53 36 targeting target VBG cord-300360-h6gr91eg 53 37 of of IN cord-300360-h6gr91eg 53 38 SARS SARS NNP cord-300360-h6gr91eg 53 39 - - HYPH cord-300360-h6gr91eg 53 40 CoV CoV NNP cord-300360-h6gr91eg 53 41 and and CC cord-300360-h6gr91eg 53 42 SARS SARS NNP cord-300360-h6gr91eg 53 43 - - HYPH cord-300360-h6gr91eg 53 44 CoV-2 CoV-2 NNP cord-300360-h6gr91eg 53 45 [ [ -LRB- cord-300360-h6gr91eg 53 46 27 27 CD cord-300360-h6gr91eg 53 47 ] ] -RRB- cord-300360-h6gr91eg 53 48 . . . cord-300360-h6gr91eg 54 1 Therefore therefore RB cord-300360-h6gr91eg 54 2 , , , cord-300360-h6gr91eg 54 3 T4 T4 NNP cord-300360-h6gr91eg 54 4 phage phage NN cord-300360-h6gr91eg 54 5 could could MD cord-300360-h6gr91eg 54 6 also also RB cord-300360-h6gr91eg 54 7 compete compete VB cord-300360-h6gr91eg 54 8 with with IN cord-300360-h6gr91eg 54 9 coronaviruses coronaviruse NNS cord-300360-h6gr91eg 54 10 and and CC cord-300360-h6gr91eg 54 11 angiotensin angiotensin NN cord-300360-h6gr91eg 54 12 - - HYPH cord-300360-h6gr91eg 54 13 converting convert VBG cord-300360-h6gr91eg 54 14 enzyme enzyme NN cord-300360-h6gr91eg 54 15 2 2 CD cord-300360-h6gr91eg 54 16 binding binding NN cord-300360-h6gr91eg 54 17 and and CC cord-300360-h6gr91eg 54 18 thereby thereby RB cord-300360-h6gr91eg 54 19 inhibit inhibit VB cord-300360-h6gr91eg 54 20 coronavirus coronavirus NN cord-300360-h6gr91eg 54 21 infection infection NN cord-300360-h6gr91eg 54 22 of of IN cord-300360-h6gr91eg 54 23 target target NN cord-300360-h6gr91eg 54 24 cells cell NNS cord-300360-h6gr91eg 54 25 . . . cord-300360-h6gr91eg 55 1 Both both DT cord-300360-h6gr91eg 55 2 T4 T4 NNP cord-300360-h6gr91eg 55 3 and and CC cord-300360-h6gr91eg 55 4 A5/80 A5/80 NNP cord-300360-h6gr91eg 55 5 antistaphylococcal antistaphylococcal JJ cord-300360-h6gr91eg 55 6 phages phage NNS cord-300360-h6gr91eg 55 7 significantly significantly RB cord-300360-h6gr91eg 55 8 reduced reduce VBD cord-300360-h6gr91eg 55 9 the the DT cord-300360-h6gr91eg 55 10 expression expression NN cord-300360-h6gr91eg 55 11 of of IN cord-300360-h6gr91eg 55 12 HAdV hadv JJ cord-300360-h6gr91eg 55 13 genes gene NNS cord-300360-h6gr91eg 55 14 while while IN cord-300360-h6gr91eg 55 15 synthesis synthesis NN cord-300360-h6gr91eg 55 16 of of IN cord-300360-h6gr91eg 55 17 HAdV HAdV NNP cord-300360-h6gr91eg 55 18 DNA DNA NNP cord-300360-h6gr91eg 55 19 was be VBD cord-300360-h6gr91eg 55 20 inhibited inhibit VBN cord-300360-h6gr91eg 55 21 only only RB cord-300360-h6gr91eg 55 22 by by IN cord-300360-h6gr91eg 55 23 the the DT cord-300360-h6gr91eg 55 24 T4 T4 NNP cord-300360-h6gr91eg 55 25 phage phage NN cord-300360-h6gr91eg 55 26 [ [ -LRB- cord-300360-h6gr91eg 55 27 28 28 CD cord-300360-h6gr91eg 55 28 ] ] -RRB- cord-300360-h6gr91eg 55 29 . . . cord-300360-h6gr91eg 56 1 Pathogenic pathogenic JJ cord-300360-h6gr91eg 56 2 viruses virus NNS cord-300360-h6gr91eg 56 3 ( ( -LRB- cord-300360-h6gr91eg 56 4 including include VBG cord-300360-h6gr91eg 56 5 coronaviruses coronaviruse NNS cord-300360-h6gr91eg 56 6 ) ) -RRB- cord-300360-h6gr91eg 56 7 induce induce VBP cord-300360-h6gr91eg 56 8 NF NF NNP cord-300360-h6gr91eg 56 9 - - HYPH cord-300360-h6gr91eg 56 10 κB κb CD cord-300360-h6gr91eg 56 11 transcription transcription NN cord-300360-h6gr91eg 56 12 factor factor NN cord-300360-h6gr91eg 56 13 upregulating upregulate VBG cord-300360-h6gr91eg 56 14 the the DT cord-300360-h6gr91eg 56 15 expression expression NN cord-300360-h6gr91eg 56 16 of of IN cord-300360-h6gr91eg 56 17 genes gene NNS cord-300360-h6gr91eg 56 18 involved involve VBN cord-300360-h6gr91eg 56 19 in in IN cord-300360-h6gr91eg 56 20 immune immune JJ cord-300360-h6gr91eg 56 21 response response NN cord-300360-h6gr91eg 56 22 [ [ -LRB- cord-300360-h6gr91eg 56 23 11 11 CD cord-300360-h6gr91eg 56 24 ] ] -RRB- cord-300360-h6gr91eg 56 25 . . . cord-300360-h6gr91eg 57 1 Preincubation preincubation NN cord-300360-h6gr91eg 57 2 of of IN cord-300360-h6gr91eg 57 3 endothelial endothelial JJ cord-300360-h6gr91eg 57 4 and and CC cord-300360-h6gr91eg 57 5 epithelial epithelial JJ cord-300360-h6gr91eg 57 6 cells cell NNS cord-300360-h6gr91eg 57 7 with with IN cord-300360-h6gr91eg 57 8 the the DT cord-300360-h6gr91eg 57 9 T4 T4 NNP cord-300360-h6gr91eg 57 10 phage phage NN cord-300360-h6gr91eg 57 11 can can MD cord-300360-h6gr91eg 57 12 abolish abolish VB cord-300360-h6gr91eg 57 13 or or CC cord-300360-h6gr91eg 57 14 significantly significantly RB cord-300360-h6gr91eg 57 15 reduce reduce VB cord-300360-h6gr91eg 57 16 NF nf NN cord-300360-h6gr91eg 57 17 - - HYPH cord-300360-h6gr91eg 57 18 κB κb CD cord-300360-h6gr91eg 57 19 activation activation NN cord-300360-h6gr91eg 57 20 triggered trigger VBN cord-300360-h6gr91eg 57 21 by by IN cord-300360-h6gr91eg 57 22 herpes herpes NN cord-300360-h6gr91eg 57 23 virus virus NN cord-300360-h6gr91eg 57 24 [ [ -LRB- cord-300360-h6gr91eg 57 25 29 29 CD cord-300360-h6gr91eg 57 26 ] ] -RRB- cord-300360-h6gr91eg 57 27 . . . cord-300360-h6gr91eg 58 1 Interestingly interestingly RB cord-300360-h6gr91eg 58 2 , , , cord-300360-h6gr91eg 58 3 Zhang Zhang NNP cord-300360-h6gr91eg 58 4 et et NNP cord-300360-h6gr91eg 58 5 al al NNP cord-300360-h6gr91eg 58 6 . . . cord-300360-h6gr91eg 59 1 [ [ -LRB- cord-300360-h6gr91eg 59 2 30 30 CD cord-300360-h6gr91eg 59 3 ] ] -RRB- cord-300360-h6gr91eg 59 4 . . . cord-300360-h6gr91eg 60 1 reported report VBD cord-300360-h6gr91eg 60 2 similar similar JJ cord-300360-h6gr91eg 60 3 effects effect NNS cord-300360-h6gr91eg 60 4 using use VBG cord-300360-h6gr91eg 60 5 an an DT cord-300360-h6gr91eg 60 6 antistaphylococcal antistaphylococcal JJ cord-300360-h6gr91eg 60 7 phage phage NN cord-300360-h6gr91eg 60 8 . . . cord-300360-h6gr91eg 61 1 Lung lung NN cord-300360-h6gr91eg 61 2 infection infection NN cord-300360-h6gr91eg 61 3 with with IN cord-300360-h6gr91eg 61 4 respiratory respiratory JJ cord-300360-h6gr91eg 61 5 viruses virus NNS cord-300360-h6gr91eg 61 6 is be VBZ cord-300360-h6gr91eg 61 7 associated associate VBN cord-300360-h6gr91eg 61 8 with with IN cord-300360-h6gr91eg 61 9 inflammation inflammation NN cord-300360-h6gr91eg 61 10 and and CC cord-300360-h6gr91eg 61 11 cell cell NN cord-300360-h6gr91eg 61 12 death death NN cord-300360-h6gr91eg 61 13 caused cause VBN cord-300360-h6gr91eg 61 14 by by IN cord-300360-h6gr91eg 61 15 excessive excessive JJ cord-300360-h6gr91eg 61 16 reactive reactive JJ cord-300360-h6gr91eg 61 17 oxygen oxygen NN cord-300360-h6gr91eg 61 18 species specie NNS cord-300360-h6gr91eg 62 1 ( ( -LRB- cord-300360-h6gr91eg 62 2 ROS ROS NNP cord-300360-h6gr91eg 62 3 ) ) -RRB- cord-300360-h6gr91eg 62 4 production production NN cord-300360-h6gr91eg 62 5 and and CC cord-300360-h6gr91eg 62 6 the the DT cord-300360-h6gr91eg 62 7 correlation correlation NN cord-300360-h6gr91eg 62 8 between between IN cord-300360-h6gr91eg 62 9 severity severity NN cord-300360-h6gr91eg 62 10 of of IN cord-300360-h6gr91eg 62 11 lung lung NN cord-300360-h6gr91eg 62 12 injury injury NN cord-300360-h6gr91eg 62 13 and and CC cord-300360-h6gr91eg 62 14 the the DT cord-300360-h6gr91eg 62 15 markers marker NNS cord-300360-h6gr91eg 62 16 of of IN cord-300360-h6gr91eg 62 17 oxidative oxidative JJ cord-300360-h6gr91eg 62 18 stress stress NN cord-300360-h6gr91eg 62 19 was be VBD cord-300360-h6gr91eg 62 20 noted note VBN cord-300360-h6gr91eg 62 21 in in IN cord-300360-h6gr91eg 62 22 patients patient NNS cord-300360-h6gr91eg 62 23 infected infect VBN cord-300360-h6gr91eg 62 24 with with IN cord-300360-h6gr91eg 62 25 the the DT cord-300360-h6gr91eg 62 26 human human JJ cord-300360-h6gr91eg 62 27 respiratory respiratory JJ cord-300360-h6gr91eg 62 28 syncytial syncytial JJ cord-300360-h6gr91eg 62 29 virus virus NN cord-300360-h6gr91eg 62 30 [ [ -LRB- cord-300360-h6gr91eg 62 31 31 31 CD cord-300360-h6gr91eg 62 32 ] ] -RRB- cord-300360-h6gr91eg 62 33 . . . cord-300360-h6gr91eg 63 1 Moreover moreover RB cord-300360-h6gr91eg 63 2 , , , cord-300360-h6gr91eg 63 3 cellular cellular JJ cord-300360-h6gr91eg 63 4 ROS ROS NNP cord-300360-h6gr91eg 63 5 are be VBP cord-300360-h6gr91eg 63 6 markedly markedly RB cord-300360-h6gr91eg 63 7 increased increase VBN cord-300360-h6gr91eg 63 8 in in IN cord-300360-h6gr91eg 63 9 SARS SARS NNP cord-300360-h6gr91eg 63 10 - - HYPH cord-300360-h6gr91eg 63 11 CoV CoV NNP cord-300360-h6gr91eg 63 12 expressing express VBG cord-300360-h6gr91eg 63 13 cells cell NNS cord-300360-h6gr91eg 63 14 [ [ -LRB- cord-300360-h6gr91eg 63 15 11 11 CD cord-300360-h6gr91eg 63 16 ] ] -RRB- cord-300360-h6gr91eg 63 17 , , , cord-300360-h6gr91eg 63 18 while while IN cord-300360-h6gr91eg 63 19 high high JJ cord-300360-h6gr91eg 63 20 levels level NNS cord-300360-h6gr91eg 63 21 of of IN cord-300360-h6gr91eg 63 22 ROS ROS NNP cord-300360-h6gr91eg 63 23 associated associate VBN cord-300360-h6gr91eg 63 24 with with IN cord-300360-h6gr91eg 63 25 a a DT cord-300360-h6gr91eg 63 26 decrease decrease NN cord-300360-h6gr91eg 63 27 in in IN cord-300360-h6gr91eg 63 28 chest chest NN cord-300360-h6gr91eg 63 29 radiographic radiographic JJ cord-300360-h6gr91eg 63 30 scores score NNS cord-300360-h6gr91eg 63 31 are be VBP cord-300360-h6gr91eg 63 32 observed observe VBN cord-300360-h6gr91eg 63 33 early early RB cord-300360-h6gr91eg 63 34 in in IN cord-300360-h6gr91eg 63 35 COVID-19 COVID-19 NNP cord-300360-h6gr91eg 63 36 [ [ -LRB- cord-300360-h6gr91eg 63 37 32 32 CD cord-300360-h6gr91eg 63 38 ] ] -RRB- cord-300360-h6gr91eg 63 39 . . . cord-300360-h6gr91eg 64 1 Phages phage NNS cord-300360-h6gr91eg 64 2 are be VBP cord-300360-h6gr91eg 64 3 known know VBN cord-300360-h6gr91eg 64 4 to to TO cord-300360-h6gr91eg 64 5 downregulate downregulate VB cord-300360-h6gr91eg 64 6 ROS ROS NNP cord-300360-h6gr91eg 64 7 production production NN cord-300360-h6gr91eg 64 8 [ [ -LRB- cord-300360-h6gr91eg 64 9 9 9 CD cord-300360-h6gr91eg 64 10 ] ] -RRB- cord-300360-h6gr91eg 64 11 . . . cord-300360-h6gr91eg 65 1 Many many JJ cord-300360-h6gr91eg 65 2 studies study NNS cord-300360-h6gr91eg 65 3 point point VBP cord-300360-h6gr91eg 65 4 to to IN cord-300360-h6gr91eg 65 5 the the DT cord-300360-h6gr91eg 65 6 positive positive JJ cord-300360-h6gr91eg 65 7 role role NN cord-300360-h6gr91eg 65 8 of of IN cord-300360-h6gr91eg 65 9 anti anti JJ cord-300360-h6gr91eg 65 10 - - JJ cord-300360-h6gr91eg 65 11 oxidant oxidant JJ cord-300360-h6gr91eg 65 12 therapy therapy NN cord-300360-h6gr91eg 65 13 in in IN cord-300360-h6gr91eg 65 14 infected infected JJ cord-300360-h6gr91eg 65 15 cells cell NNS cord-300360-h6gr91eg 65 16 and and CC cord-300360-h6gr91eg 65 17 animals animal NNS cord-300360-h6gr91eg 65 18 ; ; : cord-300360-h6gr91eg 65 19 however however RB cord-300360-h6gr91eg 65 20 , , , cord-300360-h6gr91eg 65 21 there there EX cord-300360-h6gr91eg 65 22 are be VBP cord-300360-h6gr91eg 65 23 almost almost RB cord-300360-h6gr91eg 65 24 no no DT cord-300360-h6gr91eg 65 25 clinical clinical JJ cord-300360-h6gr91eg 65 26 data datum NNS cord-300360-h6gr91eg 65 27 [ [ -LRB- cord-300360-h6gr91eg 65 28 31 31 CD cord-300360-h6gr91eg 65 29 ] ] -RRB- cord-300360-h6gr91eg 65 30 . . . cord-300360-h6gr91eg 66 1 Nevertheless nevertheless RB cord-300360-h6gr91eg 66 2 , , , cord-300360-h6gr91eg 66 3 anti anti JJ cord-300360-h6gr91eg 66 4 - - JJ cord-300360-h6gr91eg 66 5 oxidant oxidant JJ cord-300360-h6gr91eg 66 6 supplementation supplementation NN cord-300360-h6gr91eg 66 7 was be VBD cord-300360-h6gr91eg 66 8 recommended recommend VBN cord-300360-h6gr91eg 66 9 for for IN cord-300360-h6gr91eg 66 10 the the DT cord-300360-h6gr91eg 66 11 treatment treatment NN cord-300360-h6gr91eg 66 12 of of IN cord-300360-h6gr91eg 66 13 COVID-19 COVID-19 NNP cord-300360-h6gr91eg 66 14 [ [ -LRB- cord-300360-h6gr91eg 66 15 33 33 CD cord-300360-h6gr91eg 66 16 , , , cord-300360-h6gr91eg 66 17 34 34 CD cord-300360-h6gr91eg 66 18 ] ] -RRB- cord-300360-h6gr91eg 66 19 . . . cord-300360-h6gr91eg 67 1 There there EX cord-300360-h6gr91eg 67 2 are be VBP cord-300360-h6gr91eg 67 3 also also RB cord-300360-h6gr91eg 67 4 data datum NNS cord-300360-h6gr91eg 67 5 suggesting suggest VBG cord-300360-h6gr91eg 67 6 that that IN cord-300360-h6gr91eg 67 7 phages phage NNS cord-300360-h6gr91eg 67 8 may may MD cord-300360-h6gr91eg 67 9 drive drive VB cord-300360-h6gr91eg 67 10 antiviral antiviral JJ cord-300360-h6gr91eg 67 11 immunity immunity NN cord-300360-h6gr91eg 67 12 by by IN cord-300360-h6gr91eg 67 13 inducing induce VBG cord-300360-h6gr91eg 67 14 antiviral antiviral JJ cord-300360-h6gr91eg 67 15 cytokines cytokine NNS cord-300360-h6gr91eg 67 16 , , , cord-300360-h6gr91eg 67 17 for for IN cord-300360-h6gr91eg 67 18 example example NN cord-300360-h6gr91eg 67 19 , , , cord-300360-h6gr91eg 67 20 IFN IFN NNP cord-300360-h6gr91eg 67 21 -α -α VBZ cord-300360-h6gr91eg 67 22 and and CC cord-300360-h6gr91eg 67 23 IL-12 IL-12 NNP cord-300360-h6gr91eg 67 24 . . . cord-300360-h6gr91eg 68 1 Already already RB cord-300360-h6gr91eg 68 2 in in IN cord-300360-h6gr91eg 68 3 1977 1977 CD cord-300360-h6gr91eg 68 4 , , , cord-300360-h6gr91eg 68 5 Taborsky Taborsky NNP cord-300360-h6gr91eg 68 6 and and CC cord-300360-h6gr91eg 68 7 Dolnik Dolnik NNP cord-300360-h6gr91eg 68 8 showed show VBD cord-300360-h6gr91eg 68 9 that that IN cord-300360-h6gr91eg 68 10 phage phage NN cord-300360-h6gr91eg 68 11 RNA RNA NNP cord-300360-h6gr91eg 68 12 may may MD cord-300360-h6gr91eg 68 13 induce induce VB cord-300360-h6gr91eg 68 14 IFN IFN NNP cord-300360-h6gr91eg 68 15 - - HYPH cord-300360-h6gr91eg 68 16 α α NN cord-300360-h6gr91eg 68 17 in in IN cord-300360-h6gr91eg 68 18 human human JJ cord-300360-h6gr91eg 68 19 granulocytes granulocyte NNS cord-300360-h6gr91eg 68 20 [ [ -LRB- cord-300360-h6gr91eg 68 21 35 35 CD cord-300360-h6gr91eg 68 22 ] ] -RRB- cord-300360-h6gr91eg 68 23 . . . cord-300360-h6gr91eg 69 1 Recently recently RB cord-300360-h6gr91eg 69 2 , , , cord-300360-h6gr91eg 69 3 Sweere Sweere NNP cord-300360-h6gr91eg 69 4 et et FW cord-300360-h6gr91eg 69 5 al al NNP cord-300360-h6gr91eg 69 6 . . NNP cord-300360-h6gr91eg 69 7 demonstrated demonstrate VBD cord-300360-h6gr91eg 69 8 that that IN cord-300360-h6gr91eg 69 9 Pf Pf NNP cord-300360-h6gr91eg 69 10 phages phage NNS cord-300360-h6gr91eg 69 11 ( ( -LRB- cord-300360-h6gr91eg 69 12 and and CC cord-300360-h6gr91eg 69 13 phage phage NNP cord-300360-h6gr91eg 69 14 RNA RNA NNP cord-300360-h6gr91eg 69 15 ) ) -RRB- cord-300360-h6gr91eg 69 16 endocytosed endocytose VBN cord-300360-h6gr91eg 69 17 by by IN cord-300360-h6gr91eg 69 18 leukocytes leukocyte NNS cord-300360-h6gr91eg 69 19 trigger trigger NN cord-300360-h6gr91eg 69 20 TLR3-dependent tlr3-dependent NN cord-300360-h6gr91eg 69 21 pattern pattern NN cord-300360-h6gr91eg 69 22 recognition recognition NN cord-300360-h6gr91eg 69 23 receptors receptor NNS cord-300360-h6gr91eg 69 24 and and CC cord-300360-h6gr91eg 69 25 inhibit inhibit VB cord-300360-h6gr91eg 69 26 TNF tnf NN cord-300360-h6gr91eg 69 27 - - HYPH cord-300360-h6gr91eg 69 28 driving drive VBG cord-300360-h6gr91eg 69 29 type type NN cord-300360-h6gr91eg 70 1 I -PRON- PRP cord-300360-h6gr91eg 70 2 IFN IFN NNP cord-300360-h6gr91eg 70 3 production production NN cord-300360-h6gr91eg 70 4 [ [ -LRB- cord-300360-h6gr91eg 70 5 36 36 CD cord-300360-h6gr91eg 70 6 ] ] -RRB- cord-300360-h6gr91eg 70 7 . . . cord-300360-h6gr91eg 71 1 In in IN cord-300360-h6gr91eg 71 2 the the DT cord-300360-h6gr91eg 71 3 absence absence NN cord-300360-h6gr91eg 71 4 of of IN cord-300360-h6gr91eg 71 5 bacterial bacterial JJ cord-300360-h6gr91eg 71 6 infection infection NN cord-300360-h6gr91eg 71 7 , , , cord-300360-h6gr91eg 71 8 the the DT cord-300360-h6gr91eg 71 9 Escherichia Escherichia NNP cord-300360-h6gr91eg 71 10 coli coli NNS cord-300360-h6gr91eg 71 11 phage phage NN cord-300360-h6gr91eg 71 12 536 536 CD cord-300360-h6gr91eg 71 13 PI pi NN cord-300360-h6gr91eg 71 14 promotes promote VBZ cord-300360-h6gr91eg 71 15 an an DT cord-300360-h6gr91eg 71 16 increase increase NN cord-300360-h6gr91eg 71 17 in in IN cord-300360-h6gr91eg 71 18 the the DT cord-300360-h6gr91eg 71 19 production production NN cord-300360-h6gr91eg 71 20 of of IN cord-300360-h6gr91eg 71 21 IFN IFN NNP cord-300360-h6gr91eg 71 22 - - HYPH cord-300360-h6gr91eg 71 23 α α NNP cord-300360-h6gr91eg 71 24 and and CC cord-300360-h6gr91eg 71 25 IL-12 IL-12 NNP cord-300360-h6gr91eg 71 26 in in IN cord-300360-h6gr91eg 71 27 the the DT cord-300360-h6gr91eg 71 28 lungs lung NNS cord-300360-h6gr91eg 71 29 ( ( -LRB- cord-300360-h6gr91eg 71 30 but but CC cord-300360-h6gr91eg 71 31 not not RB cord-300360-h6gr91eg 71 32 in in IN cord-300360-h6gr91eg 71 33 the the DT cord-300360-h6gr91eg 71 34 blood blood NN cord-300360-h6gr91eg 71 35 ) ) -RRB- cord-300360-h6gr91eg 71 36 , , , cord-300360-h6gr91eg 71 37 allowing allow VBG cord-300360-h6gr91eg 71 38 for for IN cord-300360-h6gr91eg 71 39 the the DT cord-300360-h6gr91eg 71 40 presence presence NN cord-300360-h6gr91eg 71 41 of of IN cord-300360-h6gr91eg 71 42 an an DT cord-300360-h6gr91eg 71 43 antiviral antiviral JJ cord-300360-h6gr91eg 71 44 signature signature NN cord-300360-h6gr91eg 71 45 in in IN cord-300360-h6gr91eg 71 46 the the DT cord-300360-h6gr91eg 71 47 lungs lung NNS cord-300360-h6gr91eg 71 48 of of IN cord-300360-h6gr91eg 71 49 healthy healthy JJ cord-300360-h6gr91eg 71 50 uninfected uninfected JJ cord-300360-h6gr91eg 71 51 mice mouse NNS cord-300360-h6gr91eg 71 52 ( ( -LRB- cord-300360-h6gr91eg 71 53 this this DT cord-300360-h6gr91eg 71 54 effect effect NN cord-300360-h6gr91eg 71 55 was be VBD cord-300360-h6gr91eg 71 56 phage phage NN cord-300360-h6gr91eg 71 57 specific specific JJ cord-300360-h6gr91eg 71 58 and and CC cord-300360-h6gr91eg 71 59 mediated mediate VBN cord-300360-h6gr91eg 71 60 by by IN cord-300360-h6gr91eg 71 61 536 536 CD cord-300360-h6gr91eg 71 62 P1 P1 NNP cord-300360-h6gr91eg 71 63 and and CC cord-300360-h6gr91eg 71 64 not not RB cord-300360-h6gr91eg 71 65 LM33 LM33 NNP cord-300360-h6gr91eg 71 66 P1 P1 NNP cord-300360-h6gr91eg 71 67 phages phage NNS cord-300360-h6gr91eg 71 68 ) ) -RRB- cord-300360-h6gr91eg 71 69 [ [ -LRB- cord-300360-h6gr91eg 71 70 37 37 CD cord-300360-h6gr91eg 71 71 ] ] -RRB- cord-300360-h6gr91eg 71 72 . . . cord-300360-h6gr91eg 72 1 This this DT cord-300360-h6gr91eg 72 2 phage phage NN cord-300360-h6gr91eg 72 3 - - HYPH cord-300360-h6gr91eg 72 4 dependent dependent JJ cord-300360-h6gr91eg 72 5 antiviral antiviral JJ cord-300360-h6gr91eg 72 6 signature signature NN cord-300360-h6gr91eg 72 7 in in IN cord-300360-h6gr91eg 72 8 the the DT cord-300360-h6gr91eg 72 9 lungs lung NNS cord-300360-h6gr91eg 72 10 may may MD cord-300360-h6gr91eg 72 11 occur occur VB cord-300360-h6gr91eg 72 12 since since IN cord-300360-h6gr91eg 72 13 phages phage NNS cord-300360-h6gr91eg 72 14 have have VBP cord-300360-h6gr91eg 72 15 the the DT cord-300360-h6gr91eg 72 16 ability ability NN cord-300360-h6gr91eg 72 17 to to TO cord-300360-h6gr91eg 72 18 penetrate penetrate VB cord-300360-h6gr91eg 72 19 this this DT cord-300360-h6gr91eg 72 20 organ organ NN cord-300360-h6gr91eg 72 21 through through IN cord-300360-h6gr91eg 72 22 multiple multiple JJ cord-300360-h6gr91eg 72 23 routes route NNS cord-300360-h6gr91eg 72 24 , , , cord-300360-h6gr91eg 72 25 so so IN cord-300360-h6gr91eg 72 26 phage phage NN cord-300360-h6gr91eg 72 27 therapy therapy NN cord-300360-h6gr91eg 72 28 has have VBZ cord-300360-h6gr91eg 72 29 been be VBN cord-300360-h6gr91eg 72 30 used use VBN cord-300360-h6gr91eg 72 31 successfully successfully RB cord-300360-h6gr91eg 72 32 in in IN cord-300360-h6gr91eg 72 33 bacterial bacterial JJ cord-300360-h6gr91eg 72 34 infections infection NNS cord-300360-h6gr91eg 72 35 of of IN cord-300360-h6gr91eg 72 36 the the DT cord-300360-h6gr91eg 72 37 lungs lung NNS cord-300360-h6gr91eg 72 38 in in IN cord-300360-h6gr91eg 72 39 animals animal NNS cord-300360-h6gr91eg 72 40 and and CC cord-300360-h6gr91eg 72 41 humans human NNS cord-300360-h6gr91eg 72 42 [ [ -LRB- cord-300360-h6gr91eg 72 43 38 38 CD cord-300360-h6gr91eg 72 44 ] ] -RRB- cord-300360-h6gr91eg 72 45 . . . cord-300360-h6gr91eg 73 1 Interestingly interestingly RB cord-300360-h6gr91eg 73 2 , , , cord-300360-h6gr91eg 73 3 a a DT cord-300360-h6gr91eg 73 4 healthy healthy JJ cord-300360-h6gr91eg 73 5 respiratory respiratory JJ cord-300360-h6gr91eg 73 6 virome virome NN cord-300360-h6gr91eg 73 7 includes include VBZ cord-300360-h6gr91eg 73 8 phages phage NNS cord-300360-h6gr91eg 73 9 , , , cord-300360-h6gr91eg 73 10 while while IN cord-300360-h6gr91eg 73 11 the the DT cord-300360-h6gr91eg 73 12 incidence incidence NN cord-300360-h6gr91eg 73 13 of of IN cord-300360-h6gr91eg 73 14 viral viral JJ cord-300360-h6gr91eg 73 15 pathogens pathogen NNS cord-300360-h6gr91eg 73 16 ( ( -LRB- cord-300360-h6gr91eg 73 17 including include VBG cord-300360-h6gr91eg 73 18 CoV CoV NNP cord-300360-h6gr91eg 73 19 ) ) -RRB- cord-300360-h6gr91eg 73 20 is be VBZ cord-300360-h6gr91eg 73 21 associated associate VBN cord-300360-h6gr91eg 73 22 with with IN cord-300360-h6gr91eg 73 23 a a DT cord-300360-h6gr91eg 73 24 reduced reduce VBN cord-300360-h6gr91eg 73 25 percentage percentage NN cord-300360-h6gr91eg 73 26 of of IN cord-300360-h6gr91eg 73 27 phages phage NNS cord-300360-h6gr91eg 73 28 [ [ -LRB- cord-300360-h6gr91eg 73 29 39 39 CD cord-300360-h6gr91eg 73 30 ] ] -RRB- cord-300360-h6gr91eg 73 31 . . . cord-300360-h6gr91eg 74 1 Recent recent JJ cord-300360-h6gr91eg 74 2 data datum NNS cord-300360-h6gr91eg 74 3 by by IN cord-300360-h6gr91eg 74 4 Gogokhia Gogokhia NNP cord-300360-h6gr91eg 74 5 et et NNP cord-300360-h6gr91eg 74 6 al al NNP cord-300360-h6gr91eg 74 7 . . . cord-300360-h6gr91eg 74 8 indicate indicate VBP cord-300360-h6gr91eg 74 9 that that IN cord-300360-h6gr91eg 74 10 Lactobacillus Lactobacillus NNP cord-300360-h6gr91eg 74 11 , , , cord-300360-h6gr91eg 74 12 E. E. NNP cord-300360-h6gr91eg 74 13 coli coli NNS cord-300360-h6gr91eg 74 14 and and CC cord-300360-h6gr91eg 74 15 Bacteroides Bacteroides NNP cord-300360-h6gr91eg 74 16 phages phage NNS cord-300360-h6gr91eg 74 17 and and CC cord-300360-h6gr91eg 74 18 phage phage NN cord-300360-h6gr91eg 74 19 DNA DNA NNP cord-300360-h6gr91eg 74 20 may may MD cord-300360-h6gr91eg 74 21 stimulate stimulate VB cord-300360-h6gr91eg 74 22 IFN IFN NNP cord-300360-h6gr91eg 74 23 - - HYPH cord-300360-h6gr91eg 74 24 γ γ NN cord-300360-h6gr91eg 74 25 production production NN cord-300360-h6gr91eg 74 26 via via IN cord-300360-h6gr91eg 74 27 TLR9 tlr9 CD cord-300360-h6gr91eg 74 28 activation activation NN cord-300360-h6gr91eg 74 29 [ [ -LRB- cord-300360-h6gr91eg 74 30 40 40 CD cord-300360-h6gr91eg 74 31 ] ] -RRB- cord-300360-h6gr91eg 74 32 . . . cord-300360-h6gr91eg 75 1 IFN IFN NNP cord-300360-h6gr91eg 75 2 - - HYPH cord-300360-h6gr91eg 75 3 γ γ NNP cord-300360-h6gr91eg 75 4 is be VBZ cord-300360-h6gr91eg 75 5 another another DT cord-300360-h6gr91eg 75 6 potent potent JJ cord-300360-h6gr91eg 75 7 antiviral antiviral JJ cord-300360-h6gr91eg 75 8 cytokine cytokine NN cord-300360-h6gr91eg 75 9 [ [ -LRB- cord-300360-h6gr91eg 75 10 41 41 CD cord-300360-h6gr91eg 75 11 ] ] -RRB- cord-300360-h6gr91eg 75 12 . . . cord-300360-h6gr91eg 76 1 TNF TNF NNP cord-300360-h6gr91eg 76 2 produced produce VBD cord-300360-h6gr91eg 76 3 during during IN cord-300360-h6gr91eg 76 4 inflammation inflammation NN cord-300360-h6gr91eg 76 5 is be VBZ cord-300360-h6gr91eg 76 6 relevant relevant JJ cord-300360-h6gr91eg 76 7 for for IN cord-300360-h6gr91eg 76 8 the the DT cord-300360-h6gr91eg 76 9 coordinated coordinated JJ cord-300360-h6gr91eg 76 10 development development NN cord-300360-h6gr91eg 76 11 of of IN cord-300360-h6gr91eg 76 12 the the DT cord-300360-h6gr91eg 76 13 inflammatory inflammatory JJ cord-300360-h6gr91eg 76 14 response response NN cord-300360-h6gr91eg 76 15 . . . cord-300360-h6gr91eg 77 1 However however RB cord-300360-h6gr91eg 77 2 , , , cord-300360-h6gr91eg 77 3 excessive excessive JJ cord-300360-h6gr91eg 77 4 TNF tnf NN cord-300360-h6gr91eg 77 5 production production NN cord-300360-h6gr91eg 77 6 can can MD cord-300360-h6gr91eg 77 7 cause cause VB cord-300360-h6gr91eg 77 8 an an DT cord-300360-h6gr91eg 77 9 increased increase VBN cord-300360-h6gr91eg 77 10 risk risk NN cord-300360-h6gr91eg 77 11 of of IN cord-300360-h6gr91eg 77 12 viral viral JJ cord-300360-h6gr91eg 77 13 replication replication NN cord-300360-h6gr91eg 77 14 and and CC cord-300360-h6gr91eg 77 15 bacterial bacterial JJ cord-300360-h6gr91eg 77 16 infections infection NNS cord-300360-h6gr91eg 77 17 . . . cord-300360-h6gr91eg 78 1 Therefore therefore RB cord-300360-h6gr91eg 78 2 , , , cord-300360-h6gr91eg 78 3 a a DT cord-300360-h6gr91eg 78 4 therapeutic therapeutic JJ cord-300360-h6gr91eg 78 5 agent agent NN cord-300360-h6gr91eg 78 6 whose whose WP$ cord-300360-h6gr91eg 78 7 action action NN cord-300360-h6gr91eg 78 8 could could MD cord-300360-h6gr91eg 78 9 regulate regulate VB cord-300360-h6gr91eg 78 10 TNF TNF NNP cord-300360-h6gr91eg 78 11 production production NN cord-300360-h6gr91eg 78 12 to to TO cord-300360-h6gr91eg 78 13 keep keep VB cord-300360-h6gr91eg 78 14 it -PRON- PRP cord-300360-h6gr91eg 78 15 at at IN cord-300360-h6gr91eg 78 16 levels level NNS cord-300360-h6gr91eg 78 17 optimal optimal JJ cord-300360-h6gr91eg 78 18 for for IN cord-300360-h6gr91eg 78 19 patients patient NNS cord-300360-h6gr91eg 78 20 would would MD cord-300360-h6gr91eg 78 21 be be VB cord-300360-h6gr91eg 78 22 particularly particularly RB cord-300360-h6gr91eg 78 23 welcome welcome JJ cord-300360-h6gr91eg 78 24 . . . cord-300360-h6gr91eg 79 1 Preclinical preclinical JJ cord-300360-h6gr91eg 79 2 studies study NNS cord-300360-h6gr91eg 79 3 suggest suggest VBP cord-300360-h6gr91eg 79 4 that that IN cord-300360-h6gr91eg 79 5 experimental experimental JJ cord-300360-h6gr91eg 79 6 viral viral JJ cord-300360-h6gr91eg 79 7 pneumonia pneumonia NN cord-300360-h6gr91eg 79 8 may may MD cord-300360-h6gr91eg 79 9 be be VB cord-300360-h6gr91eg 79 10 ameliorated ameliorate VBN cord-300360-h6gr91eg 79 11 by by IN cord-300360-h6gr91eg 79 12 anti anti JJ cord-300360-h6gr91eg 79 13 - - JJ cord-300360-h6gr91eg 79 14 TNF TNF NNP cord-300360-h6gr91eg 79 15 therapy therapy NN cord-300360-h6gr91eg 79 16 . . . cord-300360-h6gr91eg 80 1 As as IN cord-300360-h6gr91eg 80 2 increased increase VBN cord-300360-h6gr91eg 80 3 levels level NNS cord-300360-h6gr91eg 80 4 of of IN cord-300360-h6gr91eg 80 5 TNF TNF NNP cord-300360-h6gr91eg 80 6 are be VBP cord-300360-h6gr91eg 80 7 demonstrable demonstrable JJ cord-300360-h6gr91eg 80 8 in in IN cord-300360-h6gr91eg 80 9 blood blood NN cord-300360-h6gr91eg 80 10 and and CC cord-300360-h6gr91eg 80 11 tissue tissue NN cord-300360-h6gr91eg 80 12 samples sample NNS cord-300360-h6gr91eg 80 13 from from IN cord-300360-h6gr91eg 80 14 patients patient NNS cord-300360-h6gr91eg 80 15 with with IN cord-300360-h6gr91eg 80 16 COVID-19 COVID-19 NNP cord-300360-h6gr91eg 80 17 the the DT cord-300360-h6gr91eg 80 18 recent recent JJ cord-300360-h6gr91eg 80 19 article article NN cord-300360-h6gr91eg 80 20 in in IN cord-300360-h6gr91eg 80 21 The the DT cord-300360-h6gr91eg 80 22 Lancet Lancet NNP cord-300360-h6gr91eg 80 23 calls call VBZ cord-300360-h6gr91eg 80 24 for for IN cord-300360-h6gr91eg 80 25 urgent urgent JJ cord-300360-h6gr91eg 80 26 trials trial NNS cord-300360-h6gr91eg 80 27 of of IN cord-300360-h6gr91eg 80 28 anti anti JJ cord-300360-h6gr91eg 80 29 - - JJ cord-300360-h6gr91eg 80 30 TNF tnf JJ cord-300360-h6gr91eg 80 31 therapy therapy NN cord-300360-h6gr91eg 80 32 in in IN cord-300360-h6gr91eg 80 33 this this DT cord-300360-h6gr91eg 80 34 disorder disorder NN cord-300360-h6gr91eg 80 35 [ [ -LRB- cord-300360-h6gr91eg 80 36 42 42 CD cord-300360-h6gr91eg 80 37 ] ] -RRB- cord-300360-h6gr91eg 80 38 . . . cord-300360-h6gr91eg 81 1 As as IN cord-300360-h6gr91eg 81 2 mentioned mention VBN cord-300360-h6gr91eg 81 3 [ [ -LRB- cord-300360-h6gr91eg 81 4 36 36 CD cord-300360-h6gr91eg 81 5 ] ] -RRB- cord-300360-h6gr91eg 81 6 some some DT cord-300360-h6gr91eg 81 7 phages phage NNS cord-300360-h6gr91eg 81 8 may may MD cord-300360-h6gr91eg 81 9 inhibit inhibit VB cord-300360-h6gr91eg 81 10 TNF TNF NNP cord-300360-h6gr91eg 81 11 production production NN cord-300360-h6gr91eg 81 12 , , , cord-300360-h6gr91eg 81 13 which which WDT cord-300360-h6gr91eg 81 14 is be VBZ cord-300360-h6gr91eg 81 15 confirmed confirm VBN cord-300360-h6gr91eg 81 16 by by IN cord-300360-h6gr91eg 81 17 earlier early JJR cord-300360-h6gr91eg 81 18 data datum NNS cord-300360-h6gr91eg 81 19 by by IN cord-300360-h6gr91eg 81 20 other other JJ cord-300360-h6gr91eg 81 21 authors author NNS cord-300360-h6gr91eg 81 22 who who WP cord-300360-h6gr91eg 81 23 showed show VBD cord-300360-h6gr91eg 81 24 that that IN cord-300360-h6gr91eg 81 25 phages phage NNS cord-300360-h6gr91eg 81 26 may may MD cord-300360-h6gr91eg 81 27 downregulate downregulate VB cord-300360-h6gr91eg 81 28 TNF TNF NNP cord-300360-h6gr91eg 81 29 - - HYPH cord-300360-h6gr91eg 81 30 α α NNP cord-300360-h6gr91eg 81 31 levels level NNS cord-300360-h6gr91eg 81 32 in in IN cord-300360-h6gr91eg 81 33 serum serum NN cord-300360-h6gr91eg 81 34 and and CC cord-300360-h6gr91eg 81 35 lungs lung NNS cord-300360-h6gr91eg 81 36 of of IN cord-300360-h6gr91eg 81 37 mice mouse NNS cord-300360-h6gr91eg 81 38 with with IN cord-300360-h6gr91eg 81 39 experimental experimental JJ cord-300360-h6gr91eg 81 40 acute acute JJ cord-300360-h6gr91eg 81 41 pneumonia pneumonia NN cord-300360-h6gr91eg 81 42 [ [ -LRB- cord-300360-h6gr91eg 81 43 43 43 CD cord-300360-h6gr91eg 81 44 , , , cord-300360-h6gr91eg 81 45 44 44 CD cord-300360-h6gr91eg 81 46 ] ] -RRB- cord-300360-h6gr91eg 81 47 . . . cord-300360-h6gr91eg 82 1 Interestingly interestingly RB cord-300360-h6gr91eg 82 2 , , , cord-300360-h6gr91eg 82 3 clinical clinical JJ cord-300360-h6gr91eg 82 4 phage phage NN cord-300360-h6gr91eg 82 5 therapy therapy NN cord-300360-h6gr91eg 82 6 may may MD cord-300360-h6gr91eg 82 7 reduce reduce VB cord-300360-h6gr91eg 82 8 TNF TNF NNP cord-300360-h6gr91eg 82 9 production production NN cord-300360-h6gr91eg 82 10 when when WRB cord-300360-h6gr91eg 82 11 its -PRON- PRP$ cord-300360-h6gr91eg 82 12 pretreatment pretreatment NN cord-300360-h6gr91eg 82 13 level level NN cord-300360-h6gr91eg 82 14 is be VBZ cord-300360-h6gr91eg 82 15 high high JJ cord-300360-h6gr91eg 82 16 and and CC cord-300360-h6gr91eg 82 17 increase increase VB cord-300360-h6gr91eg 82 18 it -PRON- PRP cord-300360-h6gr91eg 82 19 in in IN cord-300360-h6gr91eg 82 20 low low JJ cord-300360-h6gr91eg 82 21 responders responder NNS cord-300360-h6gr91eg 82 22 [ [ -LRB- cord-300360-h6gr91eg 82 23 45 45 CD cord-300360-h6gr91eg 82 24 ] ] -RRB- cord-300360-h6gr91eg 82 25 . . . cord-300360-h6gr91eg 83 1 Those those DT cord-300360-h6gr91eg 83 2 data datum NNS cord-300360-h6gr91eg 83 3 may may MD cord-300360-h6gr91eg 83 4 be be VB cord-300360-h6gr91eg 83 5 considered consider VBN cord-300360-h6gr91eg 83 6 as as IN cord-300360-h6gr91eg 83 7 a a DT cord-300360-h6gr91eg 83 8 relevant relevant JJ cord-300360-h6gr91eg 83 9 argument argument NN cord-300360-h6gr91eg 83 10 for for IN cord-300360-h6gr91eg 83 11 also also RB cord-300360-h6gr91eg 83 12 considering consider VBG cord-300360-h6gr91eg 83 13 phages phage NNS cord-300360-h6gr91eg 83 14 as as IN cord-300360-h6gr91eg 83 15 a a DT cord-300360-h6gr91eg 83 16 potential potential JJ cord-300360-h6gr91eg 83 17 agent agent NN cord-300360-h6gr91eg 83 18 that that WDT cord-300360-h6gr91eg 83 19 could could MD cord-300360-h6gr91eg 83 20 help help VB cord-300360-h6gr91eg 83 21 achieving achieve VBG cord-300360-h6gr91eg 83 22 and and CC cord-300360-h6gr91eg 83 23 maintaining maintain VBG cord-300360-h6gr91eg 83 24 TNF TNF NNP cord-300360-h6gr91eg 83 25 levels level NNS cord-300360-h6gr91eg 83 26 , , , cord-300360-h6gr91eg 83 27 allowing allow VBG cord-300360-h6gr91eg 83 28 for for IN cord-300360-h6gr91eg 83 29 appropriate appropriate JJ cord-300360-h6gr91eg 83 30 antiviral antiviral JJ cord-300360-h6gr91eg 83 31 immune immune JJ cord-300360-h6gr91eg 83 32 responses response NNS cord-300360-h6gr91eg 83 33 in in IN cord-300360-h6gr91eg 83 34 COVID-19 COVID-19 NNP cord-300360-h6gr91eg 83 35 while while IN cord-300360-h6gr91eg 83 36 reducing reduce VBG cord-300360-h6gr91eg 83 37 the the DT cord-300360-h6gr91eg 83 38 risks risk NNS cord-300360-h6gr91eg 83 39 of of IN cord-300360-h6gr91eg 83 40 excessive excessive JJ cord-300360-h6gr91eg 83 41 immunosuppression immunosuppression NN cord-300360-h6gr91eg 83 42 . . . cord-300360-h6gr91eg 84 1 Phages phage NNS cord-300360-h6gr91eg 84 2 may may MD cord-300360-h6gr91eg 84 3 also also RB cord-300360-h6gr91eg 84 4 interact interact VB cord-300360-h6gr91eg 84 5 with with IN cord-300360-h6gr91eg 84 6 TLR TLR NNP cord-300360-h6gr91eg 84 7 . . . cord-300360-h6gr91eg 85 1 In in IN cord-300360-h6gr91eg 85 2 this this DT cord-300360-h6gr91eg 85 3 regard regard NN cord-300360-h6gr91eg 85 4 , , , cord-300360-h6gr91eg 85 5 we -PRON- PRP cord-300360-h6gr91eg 85 6 have have VBP cord-300360-h6gr91eg 85 7 shown show VBN cord-300360-h6gr91eg 85 8 that that IN cord-300360-h6gr91eg 85 9 the the DT cord-300360-h6gr91eg 85 10 T4 T4 NNP cord-300360-h6gr91eg 85 11 phage phage NN cord-300360-h6gr91eg 85 12 increases increase VBZ cord-300360-h6gr91eg 85 13 the the DT cord-300360-h6gr91eg 85 14 expression expression NN cord-300360-h6gr91eg 85 15 of of IN cord-300360-h6gr91eg 85 16 the the DT cord-300360-h6gr91eg 85 17 TLR2 TLR2 NNP cord-300360-h6gr91eg 85 18 gene gene NN cord-300360-h6gr91eg 85 19 [ [ -LRB- cord-300360-h6gr91eg 85 20 15 15 CD cord-300360-h6gr91eg 85 21 ] ] -RRB- cord-300360-h6gr91eg 85 22 . . . cord-300360-h6gr91eg 86 1 TLR2 TLR2 NNP cord-300360-h6gr91eg 86 2 is be VBZ cord-300360-h6gr91eg 86 3 involved involve VBN cord-300360-h6gr91eg 86 4 in in IN cord-300360-h6gr91eg 86 5 antiviral antiviral JJ cord-300360-h6gr91eg 86 6 responses response NNS cord-300360-h6gr91eg 86 7 as as IN cord-300360-h6gr91eg 86 8 a a DT cord-300360-h6gr91eg 86 9 result result NN cord-300360-h6gr91eg 86 10 of of IN cord-300360-h6gr91eg 86 11 recognition recognition NN cord-300360-h6gr91eg 86 12 of of IN cord-300360-h6gr91eg 86 13 the the DT cord-300360-h6gr91eg 86 14 repeating repeat VBG cord-300360-h6gr91eg 86 15 protein protein NN cord-300360-h6gr91eg 86 16 subunit subunit NN cord-300360-h6gr91eg 86 17 patterns pattern NNS cord-300360-h6gr91eg 86 18 common common JJ cord-300360-h6gr91eg 86 19 to to IN cord-300360-h6gr91eg 86 20 many many JJ cord-300360-h6gr91eg 86 21 viral viral JJ cord-300360-h6gr91eg 86 22 capsids capsid NNS cord-300360-h6gr91eg 86 23 [ [ -LRB- cord-300360-h6gr91eg 86 24 46 46 CD cord-300360-h6gr91eg 86 25 ] ] -RRB- cord-300360-h6gr91eg 86 26 . . . cord-300360-h6gr91eg 87 1 Other other JJ cord-300360-h6gr91eg 87 2 antiviral antiviral JJ cord-300360-h6gr91eg 87 3 effects effect NNS cord-300360-h6gr91eg 87 4 could could MD cord-300360-h6gr91eg 87 5 be be VB cord-300360-h6gr91eg 87 6 mediated mediate VBN cord-300360-h6gr91eg 87 7 by by IN cord-300360-h6gr91eg 87 8 the the DT cord-300360-h6gr91eg 87 9 A5/80 A5/80 NNP cord-300360-h6gr91eg 87 10 staphylococcal staphylococcal JJ cord-300360-h6gr91eg 87 11 phage phage NN cord-300360-h6gr91eg 87 12 through through IN cord-300360-h6gr91eg 87 13 its -PRON- PRP$ cord-300360-h6gr91eg 87 14 ability ability NN cord-300360-h6gr91eg 87 15 to to TO cord-300360-h6gr91eg 87 16 increase increase VB cord-300360-h6gr91eg 87 17 the the DT cord-300360-h6gr91eg 87 18 expression expression NN cord-300360-h6gr91eg 87 19 of of IN cord-300360-h6gr91eg 87 20 the the DT cord-300360-h6gr91eg 87 21 IL-2 IL-2 NNP cord-300360-h6gr91eg 87 22 gene gene NN cord-300360-h6gr91eg 87 23 . . . cord-300360-h6gr91eg 88 1 IL-2 IL-2 NNP cord-300360-h6gr91eg 88 2 drives drive VBZ cord-300360-h6gr91eg 88 3 NK NK NNP cord-300360-h6gr91eg 88 4 cell cell NN cord-300360-h6gr91eg 88 5 activity activity NN cord-300360-h6gr91eg 88 6 , , , cord-300360-h6gr91eg 88 7 which which WDT cord-300360-h6gr91eg 88 8 is be VBZ cord-300360-h6gr91eg 88 9 important important JJ cord-300360-h6gr91eg 88 10 in in IN cord-300360-h6gr91eg 88 11 the the DT cord-300360-h6gr91eg 88 12 defense defense NN cord-300360-h6gr91eg 88 13 against against IN cord-300360-h6gr91eg 88 14 viral viral JJ cord-300360-h6gr91eg 88 15 infections infection NNS cord-300360-h6gr91eg 88 16 [ [ -LRB- cord-300360-h6gr91eg 88 17 15 15 CD cord-300360-h6gr91eg 88 18 ] ] -RRB- cord-300360-h6gr91eg 88 19 . . . cord-300360-h6gr91eg 89 1 Phages phage NNS cord-300360-h6gr91eg 89 2 can can MD cord-300360-h6gr91eg 89 3 also also RB cord-300360-h6gr91eg 89 4 induce induce VB cord-300360-h6gr91eg 89 5 antiviral antiviral JJ cord-300360-h6gr91eg 89 6 immunity immunity NN cord-300360-h6gr91eg 89 7 by by IN cord-300360-h6gr91eg 89 8 upregulating upregulate VBG cord-300360-h6gr91eg 89 9 expression expression NN cord-300360-h6gr91eg 89 10 of of IN cord-300360-h6gr91eg 89 11 defensin defensin NNP cord-300360-h6gr91eg 89 12 2 2 CD cord-300360-h6gr91eg 89 13 , , , cord-300360-h6gr91eg 89 14 we -PRON- PRP cord-300360-h6gr91eg 89 15 have have VBP cord-300360-h6gr91eg 89 16 recently recently RB cord-300360-h6gr91eg 89 17 shown show VBN cord-300360-h6gr91eg 89 18 that that IN cord-300360-h6gr91eg 89 19 the the DT cord-300360-h6gr91eg 89 20 T4 T4 NNP cord-300360-h6gr91eg 89 21 phage phage NN cord-300360-h6gr91eg 89 22 may may MD cord-300360-h6gr91eg 89 23 induce induce VB cord-300360-h6gr91eg 89 24 a a DT cord-300360-h6gr91eg 89 25 marked marked JJ cord-300360-h6gr91eg 89 26 upregulation upregulation NN cord-300360-h6gr91eg 89 27 of of IN cord-300360-h6gr91eg 89 28 gene gene NN cord-300360-h6gr91eg 89 29 coding coding NN cord-300360-h6gr91eg 89 30 for for IN cord-300360-h6gr91eg 89 31 hBD2 hBD2 NNP cord-300360-h6gr91eg 89 32 , , , cord-300360-h6gr91eg 89 33 a a DT cord-300360-h6gr91eg 89 34 multifunctional multifunctional JJ cord-300360-h6gr91eg 89 35 peptide peptide NN cord-300360-h6gr91eg 89 36 expressed express VBN cord-300360-h6gr91eg 89 37 mainly mainly RB cord-300360-h6gr91eg 89 38 in in IN cord-300360-h6gr91eg 89 39 epithelial epithelial JJ cord-300360-h6gr91eg 89 40 cells cell NNS cord-300360-h6gr91eg 89 41 with with IN cord-300360-h6gr91eg 89 42 antiviral antiviral JJ cord-300360-h6gr91eg 89 43 activity activity NN cord-300360-h6gr91eg 89 44 [ [ -LRB- cord-300360-h6gr91eg 89 45 47 47 CD cord-300360-h6gr91eg 89 46 ] ] -RRB- cord-300360-h6gr91eg 89 47 . . . cord-300360-h6gr91eg 90 1 Viral viral JJ cord-300360-h6gr91eg 90 2 inactivation inactivation NN cord-300360-h6gr91eg 90 3 by by IN cord-300360-h6gr91eg 90 4 that that DT cord-300360-h6gr91eg 90 5 peptide peptide NN cord-300360-h6gr91eg 90 6 includes include VBZ cord-300360-h6gr91eg 90 7 direct direct JJ cord-300360-h6gr91eg 90 8 binding binding NN cord-300360-h6gr91eg 90 9 of of IN cord-300360-h6gr91eg 90 10 the the DT cord-300360-h6gr91eg 90 11 virus virus NN cord-300360-h6gr91eg 90 12 by by IN cord-300360-h6gr91eg 90 13 hBD2 hbd2 NN cord-300360-h6gr91eg 90 14 , , , cord-300360-h6gr91eg 90 15 reduction reduction NN cord-300360-h6gr91eg 90 16 of of IN cord-300360-h6gr91eg 90 17 viral viral JJ cord-300360-h6gr91eg 90 18 replication replication NN cord-300360-h6gr91eg 90 19 and and CC cord-300360-h6gr91eg 90 20 modulation modulation NN cord-300360-h6gr91eg 90 21 of of IN cord-300360-h6gr91eg 90 22 signaling signal VBG cord-300360-h6gr91eg 90 23 pathways pathway NNS cord-300360-h6gr91eg 90 24 necessary necessary JJ cord-300360-h6gr91eg 90 25 for for IN cord-300360-h6gr91eg 90 26 antiviral antiviral JJ cord-300360-h6gr91eg 90 27 effects effect NNS cord-300360-h6gr91eg 90 28 , , , cord-300360-h6gr91eg 90 29 as as RB cord-300360-h6gr91eg 90 30 well well RB cord-300360-h6gr91eg 90 31 as as IN cord-300360-h6gr91eg 90 32 recruitment recruitment NN cord-300360-h6gr91eg 90 33 of of IN cord-300360-h6gr91eg 90 34 immune immune JJ cord-300360-h6gr91eg 90 35 cells cell NNS cord-300360-h6gr91eg 90 36 contributing contribute VBG cord-300360-h6gr91eg 90 37 to to IN cord-300360-h6gr91eg 90 38 antiviral antiviral JJ cord-300360-h6gr91eg 90 39 activity activity NN cord-300360-h6gr91eg 90 40 leading lead VBG cord-300360-h6gr91eg 90 41 to to IN cord-300360-h6gr91eg 90 42 downregulation downregulation NN cord-300360-h6gr91eg 90 43 of of IN cord-300360-h6gr91eg 90 44 cytopathic cytopathic JJ cord-300360-h6gr91eg 90 45 effects effect NNS cord-300360-h6gr91eg 90 46 in in IN cord-300360-h6gr91eg 90 47 human human JJ cord-300360-h6gr91eg 90 48 alveolar alveolar NN cord-300360-h6gr91eg 90 49 and and CC cord-300360-h6gr91eg 90 50 laryngeal laryngeal JJ cord-300360-h6gr91eg 90 51 epithelial epithelial JJ cord-300360-h6gr91eg 90 52 cells cell NNS cord-300360-h6gr91eg 90 53 [ [ -LRB- cord-300360-h6gr91eg 90 54 48 48 CD cord-300360-h6gr91eg 90 55 ] ] -RRB- cord-300360-h6gr91eg 90 56 . . . cord-300360-h6gr91eg 91 1 Experimental experimental JJ cord-300360-h6gr91eg 91 2 studies study NNS cord-300360-h6gr91eg 91 3 in in IN cord-300360-h6gr91eg 91 4 mice mouse NNS cord-300360-h6gr91eg 91 5 have have VBP cord-300360-h6gr91eg 91 6 revealed reveal VBN cord-300360-h6gr91eg 91 7 a a DT cord-300360-h6gr91eg 91 8 direct direct JJ cord-300360-h6gr91eg 91 9 link link NN cord-300360-h6gr91eg 91 10 between between IN cord-300360-h6gr91eg 91 11 beta beta JJ cord-300360-h6gr91eg 91 12 - - HYPH cord-300360-h6gr91eg 91 13 defensin defensin NN cord-300360-h6gr91eg 91 14 expression expression NN cord-300360-h6gr91eg 91 15 and and CC cord-300360-h6gr91eg 91 16 pulmonary pulmonary JJ cord-300360-h6gr91eg 91 17 immunity immunity NN cord-300360-h6gr91eg 91 18 . . . cord-300360-h6gr91eg 92 1 Moreover moreover RB cord-300360-h6gr91eg 92 2 , , , cord-300360-h6gr91eg 92 3 participation participation NN cord-300360-h6gr91eg 92 4 of of IN cord-300360-h6gr91eg 92 5 hBD2 hbd2 NN cord-300360-h6gr91eg 92 6 in in IN cord-300360-h6gr91eg 92 7 antiviral antiviral JJ cord-300360-h6gr91eg 92 8 defenses defense NNS cord-300360-h6gr91eg 92 9 in in IN cord-300360-h6gr91eg 92 10 the the DT cord-300360-h6gr91eg 92 11 respiratory respiratory JJ cord-300360-h6gr91eg 92 12 tract tract NN cord-300360-h6gr91eg 92 13 has have VBZ cord-300360-h6gr91eg 92 14 been be VBN cord-300360-h6gr91eg 92 15 confirmed confirm VBN cord-300360-h6gr91eg 92 16 in in IN cord-300360-h6gr91eg 92 17 human human JJ cord-300360-h6gr91eg 92 18 disorders disorder NNS cord-300360-h6gr91eg 92 19 [ [ -LRB- cord-300360-h6gr91eg 92 20 49 49 CD cord-300360-h6gr91eg 92 21 ] ] -RRB- cord-300360-h6gr91eg 92 22 . . . cord-300360-h6gr91eg 93 1 It -PRON- PRP cord-300360-h6gr91eg 93 2 has have VBZ cord-300360-h6gr91eg 93 3 been be VBN cord-300360-h6gr91eg 93 4 suggested suggest VBN cord-300360-h6gr91eg 93 5 that that IN cord-300360-h6gr91eg 93 6 phages phage NNS cord-300360-h6gr91eg 93 7 may may MD cord-300360-h6gr91eg 93 8 be be VB cord-300360-h6gr91eg 93 9 repurposed repurpose VBN cord-300360-h6gr91eg 93 10 for for IN cord-300360-h6gr91eg 93 11 the the DT cord-300360-h6gr91eg 93 12 treatment treatment NN cord-300360-h6gr91eg 93 13 of of IN cord-300360-h6gr91eg 93 14 not not RB cord-300360-h6gr91eg 93 15 only only RB cord-300360-h6gr91eg 93 16 bacterial bacterial JJ cord-300360-h6gr91eg 93 17 , , , cord-300360-h6gr91eg 93 18 but but CC cord-300360-h6gr91eg 93 19 also also RB cord-300360-h6gr91eg 93 20 nonbacterial nonbacterial JJ cord-300360-h6gr91eg 93 21 infections infection NNS cord-300360-h6gr91eg 93 22 including include VBG cord-300360-h6gr91eg 93 23 viral viral JJ cord-300360-h6gr91eg 93 24 and and CC cord-300360-h6gr91eg 93 25 fungal fungal JJ cord-300360-h6gr91eg 93 26 infections infection NNS cord-300360-h6gr91eg 93 27 ( ( -LRB- cord-300360-h6gr91eg 93 28 Adv Adv NNP cord-300360-h6gr91eg 93 29 , , , cord-300360-h6gr91eg 93 30 Epstein Epstein NNP cord-300360-h6gr91eg 93 31 - - HYPH cord-300360-h6gr91eg 93 32 Barr Barr NNP cord-300360-h6gr91eg 93 33 virus virus NN cord-300360-h6gr91eg 93 34 , , , cord-300360-h6gr91eg 93 35 Aspergillus aspergillus NN cord-300360-h6gr91eg 93 36 fumigatus fumigatus NN cord-300360-h6gr91eg 93 37 , , , cord-300360-h6gr91eg 93 38 Candida Candida NNP cord-300360-h6gr91eg 93 39 albicans albican NNS cord-300360-h6gr91eg 93 40 ) ) -RRB- cord-300360-h6gr91eg 93 41 [ [ -LRB- cord-300360-h6gr91eg 93 42 26 26 CD cord-300360-h6gr91eg 93 43 , , , cord-300360-h6gr91eg 93 44 29 29 CD cord-300360-h6gr91eg 93 45 ] ] -RRB- cord-300360-h6gr91eg 93 46 . . . cord-300360-h6gr91eg 94 1 It -PRON- PRP cord-300360-h6gr91eg 94 2 appears appear VBZ cord-300360-h6gr91eg 94 3 that that IN cord-300360-h6gr91eg 94 4 there there EX cord-300360-h6gr91eg 94 5 are be VBP cord-300360-h6gr91eg 94 6 grounds ground NNS cord-300360-h6gr91eg 94 7 to to TO cord-300360-h6gr91eg 94 8 believe believe VB cord-300360-h6gr91eg 94 9 that that IN cord-300360-h6gr91eg 94 10 phages phage NNS cord-300360-h6gr91eg 94 11 may may MD cord-300360-h6gr91eg 94 12 be be VB cord-300360-h6gr91eg 94 13 included include VBN cord-300360-h6gr91eg 94 14 among among IN cord-300360-h6gr91eg 94 15 drugs drug NNS cord-300360-h6gr91eg 94 16 currently currently RB cord-300360-h6gr91eg 94 17 being be VBG cord-300360-h6gr91eg 94 18 studied study VBN cord-300360-h6gr91eg 94 19 for for IN cord-300360-h6gr91eg 94 20 repurposing repurpose VBG cord-300360-h6gr91eg 94 21 in in IN cord-300360-h6gr91eg 94 22 the the DT cord-300360-h6gr91eg 94 23 treatment treatment NN cord-300360-h6gr91eg 94 24 of of IN cord-300360-h6gr91eg 94 25 COVID-19 COVID-19 NNP cord-300360-h6gr91eg 94 26 . . . cord-300360-h6gr91eg 95 1 Based base VBN cord-300360-h6gr91eg 95 2 on on IN cord-300360-h6gr91eg 95 3 the the DT cord-300360-h6gr91eg 95 4 above above JJ cord-300360-h6gr91eg 95 5 data datum NNS cord-300360-h6gr91eg 95 6 the the DT cord-300360-h6gr91eg 95 7 most most RBS cord-300360-h6gr91eg 95 8 likely likely JJ cord-300360-h6gr91eg 95 9 application application NN cord-300360-h6gr91eg 95 10 of of IN cord-300360-h6gr91eg 95 11 phages phage NNS cord-300360-h6gr91eg 95 12 in in IN cord-300360-h6gr91eg 95 13 COVID-19 COVID-19 NNP cord-300360-h6gr91eg 95 14 could could MD cord-300360-h6gr91eg 95 15 be be VB cord-300360-h6gr91eg 95 16 in in IN cord-300360-h6gr91eg 95 17 an an DT cord-300360-h6gr91eg 95 18 adjunct adjunct JJ cord-300360-h6gr91eg 95 19 antiviral antiviral JJ cord-300360-h6gr91eg 95 20 therapy therapy NN cord-300360-h6gr91eg 95 21 , , , cord-300360-h6gr91eg 95 22 similar similar JJ cord-300360-h6gr91eg 95 23 to to IN cord-300360-h6gr91eg 95 24 the the DT cord-300360-h6gr91eg 95 25 current current JJ cord-300360-h6gr91eg 95 26 trend trend NN cord-300360-h6gr91eg 95 27 to to TO cord-300360-h6gr91eg 95 28 combine combine VB cord-300360-h6gr91eg 95 29 phages phage NNS cord-300360-h6gr91eg 95 30 with with IN cord-300360-h6gr91eg 95 31 antibiotic antibiotic JJ cord-300360-h6gr91eg 95 32 therapy therapy NN cord-300360-h6gr91eg 95 33 in in IN cord-300360-h6gr91eg 95 34 bacterial bacterial JJ cord-300360-h6gr91eg 95 35 infections infection NNS cord-300360-h6gr91eg 95 36 . . . cord-300360-h6gr91eg 96 1 In in IN cord-300360-h6gr91eg 96 2 addition addition NN cord-300360-h6gr91eg 96 3 , , , cord-300360-h6gr91eg 96 4 standard standard JJ cord-300360-h6gr91eg 96 5 phage phage NN cord-300360-h6gr91eg 96 6 therapy therapy NN cord-300360-h6gr91eg 96 7 could could MD cord-300360-h6gr91eg 96 8 be be VB cord-300360-h6gr91eg 96 9 considered consider VBN cord-300360-h6gr91eg 96 10 for for IN cord-300360-h6gr91eg 96 11 the the DT cord-300360-h6gr91eg 96 12 treatment treatment NN cord-300360-h6gr91eg 96 13 of of IN cord-300360-h6gr91eg 96 14 bacterial bacterial JJ cord-300360-h6gr91eg 96 15 complications complication NNS cord-300360-h6gr91eg 96 16 of of IN cord-300360-h6gr91eg 96 17 COVID-19 COVID-19 NNP cord-300360-h6gr91eg 96 18 , , , cord-300360-h6gr91eg 96 19 which which WDT cord-300360-h6gr91eg 96 20 occur occur VBP cord-300360-h6gr91eg 96 21 in in IN cord-300360-h6gr91eg 96 22 > > $ cord-300360-h6gr91eg 96 23 40 40 CD cord-300360-h6gr91eg 96 24 % % NN cord-300360-h6gr91eg 96 25 of of IN cord-300360-h6gr91eg 96 26 patients patient NNS cord-300360-h6gr91eg 96 27 [ [ -LRB- cord-300360-h6gr91eg 96 28 12 12 CD cord-300360-h6gr91eg 96 29 ] ] -RRB- cord-300360-h6gr91eg 96 30 . . . cord-300360-h6gr91eg 97 1 Phages phage NNS cord-300360-h6gr91eg 97 2 may may MD cord-300360-h6gr91eg 97 3 protect protect VB cord-300360-h6gr91eg 97 4 eukaryotic eukaryotic JJ cord-300360-h6gr91eg 97 5 cells cell NNS cord-300360-h6gr91eg 97 6 by by IN cord-300360-h6gr91eg 97 7 competing compete VBG cord-300360-h6gr91eg 97 8 with with IN cord-300360-h6gr91eg 97 9 viral viral JJ cord-300360-h6gr91eg 97 10 adsorption adsorption NN cord-300360-h6gr91eg 97 11 and and CC cord-300360-h6gr91eg 97 12 viral viral JJ cord-300360-h6gr91eg 97 13 penetration penetration NN cord-300360-h6gr91eg 97 14 of of IN cord-300360-h6gr91eg 97 15 cells cell NNS cord-300360-h6gr91eg 97 16 , , , cord-300360-h6gr91eg 97 17 virusmediated virusmediated JJ cord-300360-h6gr91eg 97 18 cell cell NN cord-300360-h6gr91eg 97 19 apoptosis apoptosis NN cord-300360-h6gr91eg 97 20 as as RB cord-300360-h6gr91eg 97 21 well well RB cord-300360-h6gr91eg 97 22 as as IN cord-300360-h6gr91eg 97 23 viral viral JJ cord-300360-h6gr91eg 97 24 replication replication NN cord-300360-h6gr91eg 97 25 . . . cord-300360-h6gr91eg 98 1 Phages phage NNS cord-300360-h6gr91eg 98 2 may may MD cord-300360-h6gr91eg 98 3 also also RB cord-300360-h6gr91eg 98 4 induce induce VB cord-300360-h6gr91eg 98 5 antiviral antiviral JJ cord-300360-h6gr91eg 98 6 immunity immunity NN cord-300360-h6gr91eg 98 7 while while IN cord-300360-h6gr91eg 98 8 contributing contribute VBG cord-300360-h6gr91eg 98 9 to to IN cord-300360-h6gr91eg 98 10 maintaining maintain VBG cord-300360-h6gr91eg 98 11 a a DT cord-300360-h6gr91eg 98 12 balanced balanced JJ cord-300360-h6gr91eg 98 13 immune immune JJ cord-300360-h6gr91eg 98 14 response response NN cord-300360-h6gr91eg 98 15 . . . cord-300360-h6gr91eg 99 1 Moreover moreover RB cord-300360-h6gr91eg 99 2 , , , cord-300360-h6gr91eg 99 3 by by IN cord-300360-h6gr91eg 99 4 inhibiting inhibit VBG cord-300360-h6gr91eg 99 5 activation activation NN cord-300360-h6gr91eg 99 6 of of IN cord-300360-h6gr91eg 99 7 NF nf NN cord-300360-h6gr91eg 99 8 - - HYPH cord-300360-h6gr91eg 99 9 κB κB NNP cord-300360-h6gr91eg 99 10 and and CC cord-300360-h6gr91eg 99 11 ROS ROS NNP cord-300360-h6gr91eg 99 12 production production NN cord-300360-h6gr91eg 99 13 , , , cord-300360-h6gr91eg 99 14 phages phage NNS cord-300360-h6gr91eg 99 15 can can MD cord-300360-h6gr91eg 99 16 downregulate downregulate VB cord-300360-h6gr91eg 99 17 excessive excessive JJ cord-300360-h6gr91eg 99 18 inflammatory inflammatory JJ cord-300360-h6gr91eg 99 19 reactions reaction NNS cord-300360-h6gr91eg 99 20 relevant relevant JJ cord-300360-h6gr91eg 99 21 in in IN cord-300360-h6gr91eg 99 22 pathology pathology NN cord-300360-h6gr91eg 99 23 and and CC cord-300360-h6gr91eg 99 24 clinical clinical JJ cord-300360-h6gr91eg 99 25 course course NN cord-300360-h6gr91eg 99 26 of of IN cord-300360-h6gr91eg 99 27 COVID-19 COVID-19 NNP cord-300360-h6gr91eg 99 28 . . . cord-300360-h6gr91eg 100 1 The the DT cord-300360-h6gr91eg 100 2 data datum NNS cord-300360-h6gr91eg 100 3 presented present VBN cord-300360-h6gr91eg 100 4 in in IN cord-300360-h6gr91eg 100 5 this this DT cord-300360-h6gr91eg 100 6 Commentary commentary NN cord-300360-h6gr91eg 100 7 are be VBP cord-300360-h6gr91eg 100 8 often often RB cord-300360-h6gr91eg 100 9 preliminary preliminary JJ cord-300360-h6gr91eg 100 10 but but CC cord-300360-h6gr91eg 100 11 suggest suggest VBP cord-300360-h6gr91eg 100 12 that that IN cord-300360-h6gr91eg 100 13 further further JJ cord-300360-h6gr91eg 100 14 studies study NNS cord-300360-h6gr91eg 100 15 focused focus VBD cord-300360-h6gr91eg 100 16 on on IN cord-300360-h6gr91eg 100 17 the the DT cord-300360-h6gr91eg 100 18 potential potential NN cord-300360-h6gr91eg 100 19 of of IN cord-300360-h6gr91eg 100 20 phage phage NN cord-300360-h6gr91eg 100 21 therapy therapy NN cord-300360-h6gr91eg 100 22 as as IN cord-300360-h6gr91eg 100 23 at at IN cord-300360-h6gr91eg 100 24 least least JJS cord-300360-h6gr91eg 100 25 an an DT cord-300360-h6gr91eg 100 26 adjunct adjunct JJ cord-300360-h6gr91eg 100 27 treatment treatment NN cord-300360-h6gr91eg 100 28 of of IN cord-300360-h6gr91eg 100 29 COVID-19 COVID-19 NNP cord-300360-h6gr91eg 100 30 are be VBP cord-300360-h6gr91eg 100 31 warranted warrant VBN cord-300360-h6gr91eg 100 32 . . . cord-300360-h6gr91eg 101 1 Both both DT cord-300360-h6gr91eg 101 2 general general JJ cord-300360-h6gr91eg 101 3 and and CC cord-300360-h6gr91eg 101 4 remote remote JJ cord-300360-h6gr91eg 101 5 safety safety NN cord-300360-h6gr91eg 101 6 of of IN cord-300360-h6gr91eg 101 7 phage phage NN cord-300360-h6gr91eg 101 8 therapy therapy NN cord-300360-h6gr91eg 101 9 was be VBD cord-300360-h6gr91eg 101 10 confirmed confirm VBN cord-300360-h6gr91eg 101 11 [ [ -LRB- cord-300360-h6gr91eg 101 12 23 23 CD cord-300360-h6gr91eg 101 13 , , , cord-300360-h6gr91eg 101 14 [ [ -LRB- cord-300360-h6gr91eg 101 15 50 50 CD cord-300360-h6gr91eg 101 16 ] ] -RRB- cord-300360-h6gr91eg 101 17 [ [ -LRB- cord-300360-h6gr91eg 101 18 51 51 CD cord-300360-h6gr91eg 101 19 ] ] -RRB- cord-300360-h6gr91eg 102 1 [ [ -LRB- cord-300360-h6gr91eg 102 2 52 52 CD cord-300360-h6gr91eg 102 3 ] ] -RRB- cord-300360-h6gr91eg 102 4 . . . cord-300360-h6gr91eg 103 1 Therefore therefore RB cord-300360-h6gr91eg 103 2 , , , cord-300360-h6gr91eg 103 3 more more JJR cord-300360-h6gr91eg 103 4 studies study NNS cord-300360-h6gr91eg 103 5 including include VBG cord-300360-h6gr91eg 103 6 relevant relevant JJ cord-300360-h6gr91eg 103 7 clinical clinical JJ cord-300360-h6gr91eg 103 8 trials trial NNS cord-300360-h6gr91eg 103 9 are be VBP cord-300360-h6gr91eg 103 10 needed need VBN cord-300360-h6gr91eg 103 11 to to TO cord-300360-h6gr91eg 103 12 shed shed VB cord-300360-h6gr91eg 103 13 more more JJR cord-300360-h6gr91eg 103 14 light light NN cord-300360-h6gr91eg 103 15 on on IN cord-300360-h6gr91eg 103 16 the the DT cord-300360-h6gr91eg 103 17 potential potential NN cord-300360-h6gr91eg 103 18 of of IN cord-300360-h6gr91eg 103 19 phages phage NNS cord-300360-h6gr91eg 103 20 to to TO cord-300360-h6gr91eg 103 21 help help VB cord-300360-h6gr91eg 103 22 combat combat VB cord-300360-h6gr91eg 103 23 the the DT cord-300360-h6gr91eg 103 24 COVID-19 COVID-19 NNP cord-300360-h6gr91eg 103 25 pandemic pandemic NN cord-300360-h6gr91eg 103 26 . . . cord-300360-h6gr91eg 104 1 financial financial JJ cord-300360-h6gr91eg 104 2 involvement involvement NN cord-300360-h6gr91eg 104 3 with with IN cord-300360-h6gr91eg 104 4 any any DT cord-300360-h6gr91eg 104 5 organization organization NN cord-300360-h6gr91eg 104 6 or or CC cord-300360-h6gr91eg 104 7 entity entity NN cord-300360-h6gr91eg 104 8 with with IN cord-300360-h6gr91eg 104 9 a a DT cord-300360-h6gr91eg 104 10 financial financial JJ cord-300360-h6gr91eg 104 11 interest interest NN cord-300360-h6gr91eg 104 12 in in IN cord-300360-h6gr91eg 104 13 or or CC cord-300360-h6gr91eg 104 14 financial financial JJ cord-300360-h6gr91eg 104 15 conflict conflict NN cord-300360-h6gr91eg 104 16 with with IN cord-300360-h6gr91eg 104 17 the the DT cord-300360-h6gr91eg 104 18 subject subject JJ cord-300360-h6gr91eg 104 19 matter matter NN cord-300360-h6gr91eg 104 20 or or CC cord-300360-h6gr91eg 104 21 materials material NNS cord-300360-h6gr91eg 104 22 discussed discuss VBN cord-300360-h6gr91eg 104 23 in in IN cord-300360-h6gr91eg 104 24 the the DT cord-300360-h6gr91eg 104 25 manuscript manuscript NN cord-300360-h6gr91eg 104 26 apart apart RB cord-300360-h6gr91eg 104 27 from from IN cord-300360-h6gr91eg 104 28 those those DT cord-300360-h6gr91eg 104 29 disclosed disclose VBN cord-300360-h6gr91eg 104 30 . . . cord-300360-h6gr91eg 105 1 No no DT cord-300360-h6gr91eg 105 2 writing writing NN cord-300360-h6gr91eg 105 3 assistance assistance NN cord-300360-h6gr91eg 105 4 was be VBD cord-300360-h6gr91eg 105 5 utilized utilize VBN cord-300360-h6gr91eg 105 6 in in IN cord-300360-h6gr91eg 105 7 the the DT cord-300360-h6gr91eg 105 8 production production NN cord-300360-h6gr91eg 105 9 of of IN cord-300360-h6gr91eg 105 10 this this DT cord-300360-h6gr91eg 105 11 manuscript manuscript NN cord-300360-h6gr91eg 105 12 . . . cord-300360-h6gr91eg 106 1 Management management NN cord-300360-h6gr91eg 106 2 of of IN cord-300360-h6gr91eg 106 3 critically critically RB cord-300360-h6gr91eg 106 4 ill ill JJ cord-300360-h6gr91eg 106 5 adults adult NNS cord-300360-h6gr91eg 106 6 with with IN cord-300360-h6gr91eg 106 7 COVID-19 COVID-19 NNP cord-300360-h6gr91eg 106 8 Pharmacologic Pharmacologic NNP cord-300360-h6gr91eg 106 9 treatments treatment NNS cord-300360-h6gr91eg 106 10 for for IN cord-300360-h6gr91eg 106 11 coronavirus coronavirus NN cord-300360-h6gr91eg 106 12 disease disease NN cord-300360-h6gr91eg 106 13 2019 2019 CD cord-300360-h6gr91eg 106 14 ( ( -LRB- cord-300360-h6gr91eg 106 15 COVID-19 COVID-19 NNP cord-300360-h6gr91eg 106 16 ) ) -RRB- cord-300360-h6gr91eg 106 17 : : : cord-300360-h6gr91eg 106 18 a a DT cord-300360-h6gr91eg 106 19 review review NN cord-300360-h6gr91eg 107 1 Coronavirus Coronavirus NNP cord-300360-h6gr91eg 107 2 shuts shut VBZ cord-300360-h6gr91eg 107 3 down down RP cord-300360-h6gr91eg 107 4 trials trial NNS cord-300360-h6gr91eg 107 5 of of IN cord-300360-h6gr91eg 107 6 drugs drug NNS cord-300360-h6gr91eg 107 7 for for IN cord-300360-h6gr91eg 107 8 multiple multiple JJ cord-300360-h6gr91eg 107 9 other other JJ cord-300360-h6gr91eg 107 10 diseases disease NNS cord-300360-h6gr91eg 108 1 Old old JJ cord-300360-h6gr91eg 108 2 wine wine NN cord-300360-h6gr91eg 108 3 in in IN cord-300360-h6gr91eg 108 4 new new JJ cord-300360-h6gr91eg 108 5 bottles bottle NNS cord-300360-h6gr91eg 108 6 : : : cord-300360-h6gr91eg 108 7 drug drug NN cord-300360-h6gr91eg 108 8 repurposing repurposing NN cord-300360-h6gr91eg 108 9 in in IN cord-300360-h6gr91eg 108 10 oncology oncology NN cord-300360-h6gr91eg 108 11 Repurposing Repurposing NNP cord-300360-h6gr91eg 108 12 metformin metformin NNP cord-300360-h6gr91eg 108 13 for for IN cord-300360-h6gr91eg 108 14 cardiovascular cardiovascular JJ cord-300360-h6gr91eg 108 15 disease disease NN cord-300360-h6gr91eg 108 16 Repurposing repurposing NN cord-300360-h6gr91eg 108 17 of of IN cord-300360-h6gr91eg 108 18 existing exist VBG cord-300360-h6gr91eg 108 19 drugs drug NNS cord-300360-h6gr91eg 108 20 for for IN cord-300360-h6gr91eg 108 21 the the DT cord-300360-h6gr91eg 108 22 bacterial bacterial JJ cord-300360-h6gr91eg 108 23 infections infection NNS cord-300360-h6gr91eg 108 24 : : : cord-300360-h6gr91eg 108 25 an an DT cord-300360-h6gr91eg 108 26 in in IN cord-300360-h6gr91eg 108 27 silico silico NNS cord-300360-h6gr91eg 108 28 and and CC cord-300360-h6gr91eg 108 29 in in IN cord-300360-h6gr91eg 108 30 vitro vitro FW cord-300360-h6gr91eg 108 31 study study NN cord-300360-h6gr91eg 109 1 No no DT cord-300360-h6gr91eg 109 2 ' ' `` cord-300360-h6gr91eg 109 3 magic magic JJ cord-300360-h6gr91eg 109 4 pill pill NN cord-300360-h6gr91eg 109 5 ' ' '' cord-300360-h6gr91eg 109 6 : : : cord-300360-h6gr91eg 110 1 the the DT cord-300360-h6gr91eg 110 2 fight fight NN cord-300360-h6gr91eg 110 3 over over IN cord-300360-h6gr91eg 110 4 unproven unproven JJ cord-300360-h6gr91eg 110 5 drugs drug NNS cord-300360-h6gr91eg 110 6 for for IN cord-300360-h6gr91eg 110 7 coronavirus coronavirus NN cord-300360-h6gr91eg 110 8 Phage phage NN cord-300360-h6gr91eg 110 9 therapy therapy NN cord-300360-h6gr91eg 110 10 : : : cord-300360-h6gr91eg 110 11 unexpected unexpected JJ cord-300360-h6gr91eg 110 12 drawbacks drawback NNS cord-300360-h6gr91eg 110 13 to to TO cord-300360-h6gr91eg 110 14 reach reach VB cord-300360-h6gr91eg 110 15 hospitals hospital NNS cord-300360-h6gr91eg 110 16 Bacterial bacterial JJ cord-300360-h6gr91eg 110 17 viruses virus NNS cord-300360-h6gr91eg 110 18 against against IN cord-300360-h6gr91eg 110 19 viruses virus NNS cord-300360-h6gr91eg 110 20 pathogenic pathogenic JJ cord-300360-h6gr91eg 110 21 for for IN cord-300360-h6gr91eg 110 22 man man NN cord-300360-h6gr91eg 110 23 ? ? . cord-300360-h6gr91eg 111 1 The the DT cord-300360-h6gr91eg 111 2 in in FW cord-300360-h6gr91eg 111 3 vitro vitro FW cord-300360-h6gr91eg 111 4 studies study NNS cord-300360-h6gr91eg 111 5 on on IN cord-300360-h6gr91eg 111 6 bacteriophage bacteriophage NN cord-300360-h6gr91eg 111 7 influence influence NN cord-300360-h6gr91eg 111 8 on on IN cord-300360-h6gr91eg 111 9 the the DT cord-300360-h6gr91eg 111 10 ability ability NN cord-300360-h6gr91eg 111 11 of of IN cord-300360-h6gr91eg 111 12 human human JJ cord-300360-h6gr91eg 111 13 viruses virus NNS cord-300360-h6gr91eg 111 14 to to TO cord-300360-h6gr91eg 111 15 infect infect VB cord-300360-h6gr91eg 111 16 epithelial epithelial JJ cord-300360-h6gr91eg 111 17 cells cell NNS cord-300360-h6gr91eg 111 18 . . . cord-300360-h6gr91eg 112 1 Presented present VBN cord-300360-h6gr91eg 112 2 at at IN cord-300360-h6gr91eg 112 3 : : : cord-300360-h6gr91eg 112 4 20th 20th JJ cord-300360-h6gr91eg 112 5 Biennial Biennial NNP cord-300360-h6gr91eg 112 6 Evergreen Evergreen NNP cord-300360-h6gr91eg 112 7 International International NNP cord-300360-h6gr91eg 112 8 Phage Phage NNP cord-300360-h6gr91eg 112 9 Meeting Meeting NNP cord-300360-h6gr91eg 112 10 Severe severe JJ cord-300360-h6gr91eg 112 11 acute acute JJ cord-300360-h6gr91eg 112 12 respiratory respiratory JJ cord-300360-h6gr91eg 112 13 syndrome syndrome NN cord-300360-h6gr91eg 112 14 coronavirus coronavirus NN cord-300360-h6gr91eg 112 15 3C 3c NN cord-300360-h6gr91eg 112 16 - - HYPH cord-300360-h6gr91eg 112 17 like like JJ cord-300360-h6gr91eg 112 18 protease protease NN cord-300360-h6gr91eg 112 19 - - HYPH cord-300360-h6gr91eg 112 20 induced induce VBN cord-300360-h6gr91eg 112 21 apoptosis apoptosis NN cord-300360-h6gr91eg 112 22 Coronavirus Coronavirus NNP cord-300360-h6gr91eg 112 23 disease disease NN cord-300360-h6gr91eg 112 24 2019 2019 CD cord-300360-h6gr91eg 112 25 in in IN cord-300360-h6gr91eg 112 26 elderly elderly JJ cord-300360-h6gr91eg 112 27 patients patient NNS cord-300360-h6gr91eg 112 28 : : : cord-300360-h6gr91eg 113 1 characteristics characteristic NNS cord-300360-h6gr91eg 113 2 and and CC cord-300360-h6gr91eg 113 3 prognostic prognostic JJ cord-300360-h6gr91eg 113 4 factors factor NNS cord-300360-h6gr91eg 113 5 based base VBN cord-300360-h6gr91eg 113 6 on on IN cord-300360-h6gr91eg 113 7 4-week 4-week CD cord-300360-h6gr91eg 113 8 follow follow NN cord-300360-h6gr91eg 113 9 - - HYPH cord-300360-h6gr91eg 113 10 up up NN cord-300360-h6gr91eg 113 11 Use Use NNP cord-300360-h6gr91eg 113 12 of of IN cord-300360-h6gr91eg 113 13 a a DT cord-300360-h6gr91eg 113 14 primary primary JJ cord-300360-h6gr91eg 113 15 epithelial epithelial JJ cord-300360-h6gr91eg 113 16 cell cell NN cord-300360-h6gr91eg 113 17 screening screening NN cord-300360-h6gr91eg 113 18 tool tool NN cord-300360-h6gr91eg 113 19 to to TO cord-300360-h6gr91eg 113 20 investigate investigate VB cord-300360-h6gr91eg 113 21 phage phage NN cord-300360-h6gr91eg 113 22 therapy therapy NN cord-300360-h6gr91eg 113 23 in in IN cord-300360-h6gr91eg 113 24 cystic cystic JJ cord-300360-h6gr91eg 113 25 fibrosis fibrosis NN cord-300360-h6gr91eg 114 1 The the DT cord-300360-h6gr91eg 114 2 effects effect NNS cord-300360-h6gr91eg 114 3 of of IN cord-300360-h6gr91eg 114 4 T4 T4 NNP cord-300360-h6gr91eg 114 5 and and CC cord-300360-h6gr91eg 114 6 A3 A3 NNP cord-300360-h6gr91eg 114 7 / / SYM cord-300360-h6gr91eg 114 8 R r NN cord-300360-h6gr91eg 114 9 bacteriophages bacteriophage NNS cord-300360-h6gr91eg 114 10 on on IN cord-300360-h6gr91eg 114 11 differentiation differentiation NN cord-300360-h6gr91eg 114 12 of of IN cord-300360-h6gr91eg 114 13 human human JJ cord-300360-h6gr91eg 114 14 myeloid myeloid NN cord-300360-h6gr91eg 114 15 dendritic dendritic JJ cord-300360-h6gr91eg 114 16 cells cell NNS cord-300360-h6gr91eg 115 1 The the DT cord-300360-h6gr91eg 115 2 effects effect NNS cord-300360-h6gr91eg 115 3 of of IN cord-300360-h6gr91eg 115 4 bacteriophages bacteriophage NNS cord-300360-h6gr91eg 115 5 on on IN cord-300360-h6gr91eg 115 6 the the DT cord-300360-h6gr91eg 115 7 expression expression NN cord-300360-h6gr91eg 115 8 of of IN cord-300360-h6gr91eg 115 9 genes gene NNS cord-300360-h6gr91eg 115 10 involved involve VBN cord-300360-h6gr91eg 115 11 in in IN cord-300360-h6gr91eg 115 12 antimicrobial antimicrobial JJ cord-300360-h6gr91eg 115 13 immunity immunity NN cord-300360-h6gr91eg 115 14 Phage phage NN cord-300360-h6gr91eg 115 15 - - HYPH cord-300360-h6gr91eg 115 16 specific specific JJ cord-300360-h6gr91eg 115 17 diverse diverse JJ cord-300360-h6gr91eg 115 18 effects effect NNS cord-300360-h6gr91eg 115 19 of of IN cord-300360-h6gr91eg 115 20 bacterial bacterial JJ cord-300360-h6gr91eg 115 21 viruses virus NNS cord-300360-h6gr91eg 115 22 on on IN cord-300360-h6gr91eg 115 23 the the DT cord-300360-h6gr91eg 115 24 immune immune JJ cord-300360-h6gr91eg 115 25 system system NN cord-300360-h6gr91eg 115 26 Natural natural JJ cord-300360-h6gr91eg 115 27 bacteriophages bacteriophage NNS cord-300360-h6gr91eg 115 28 T4 T4 NNP cord-300360-h6gr91eg 115 29 and and CC cord-300360-h6gr91eg 115 30 M13 M13 NNP cord-300360-h6gr91eg 115 31 down down RB cord-300360-h6gr91eg 115 32 - - HYPH cord-300360-h6gr91eg 115 33 regulates regulate NNS cord-300360-h6gr91eg 115 34 Hsp90 Hsp90 NNP cord-300360-h6gr91eg 115 35 gene gene NN cord-300360-h6gr91eg 115 36 expression expression NN cord-300360-h6gr91eg 115 37 in in IN cord-300360-h6gr91eg 115 38 human human JJ cord-300360-h6gr91eg 115 39 prostate prostate NN cord-300360-h6gr91eg 115 40 cancer cancer NN cord-300360-h6gr91eg 115 41 cells cell NNS cord-300360-h6gr91eg 115 42 ( ( -LRB- cord-300360-h6gr91eg 115 43 PC-3 PC-3 NNP cord-300360-h6gr91eg 115 44 ) ) -RRB- cord-300360-h6gr91eg 115 45 representing represent VBG cord-300360-h6gr91eg 115 46 a a DT cord-300360-h6gr91eg 115 47 potential potential JJ cord-300360-h6gr91eg 115 48 nanoparticle nanoparticle NN cord-300360-h6gr91eg 115 49 against against IN cord-300360-h6gr91eg 115 50 cancer cancer NN cord-300360-h6gr91eg 115 51 Anti anti JJ cord-300360-h6gr91eg 115 52 - - JJ cord-300360-h6gr91eg 115 53 influenza influenza JJ cord-300360-h6gr91eg 115 54 virus virus NN cord-300360-h6gr91eg 115 55 activity activity NN cord-300360-h6gr91eg 115 56 of of IN cord-300360-h6gr91eg 115 57 benzo[d]thiazoles benzo[d]thiazole NNS cord-300360-h6gr91eg 115 58 that that WDT cord-300360-h6gr91eg 115 59 target target NN cord-300360-h6gr91eg 115 60 heat heat NN cord-300360-h6gr91eg 115 61 shock shock NN cord-300360-h6gr91eg 115 62 protein protein NN cord-300360-h6gr91eg 116 1 90 90 CD cord-300360-h6gr91eg 116 2 Effect effect NN cord-300360-h6gr91eg 116 3 of of IN cord-300360-h6gr91eg 116 4 heat heat NN cord-300360-h6gr91eg 116 5 shock shock NN cord-300360-h6gr91eg 116 6 on on IN cord-300360-h6gr91eg 116 7 murine murine JJ cord-300360-h6gr91eg 116 8 norovirus norovirus NN cord-300360-h6gr91eg 116 9 replication replication NN cord-300360-h6gr91eg 116 10 in in IN cord-300360-h6gr91eg 116 11 RAW264.7 RAW264.7 NNP cord-300360-h6gr91eg 116 12 cells cell NNS cord-300360-h6gr91eg 116 13 Bacteriophage Bacteriophage NNP cord-300360-h6gr91eg 116 14 translocation translocation NN cord-300360-h6gr91eg 116 15 Epub Epub NNP cord-300360-h6gr91eg 116 16 ahead ahead RB cord-300360-h6gr91eg 116 17 of of IN cord-300360-h6gr91eg 116 18 print print NN cord-300360-h6gr91eg 116 19 ) ) -RRB- cord-300360-h6gr91eg 117 1 future future JJ cord-300360-h6gr91eg 117 2 science science NN cord-300360-h6gr91eg 117 3 group group NN cord-300360-h6gr91eg 117 4 Bacteriophage Bacteriophage NNP cord-300360-h6gr91eg 117 5 transcytosis transcytosis NNP cord-300360-h6gr91eg 117 6 provides provide VBZ cord-300360-h6gr91eg 117 7 a a DT cord-300360-h6gr91eg 117 8 mechanism mechanism NN cord-300360-h6gr91eg 117 9 to to TO cord-300360-h6gr91eg 117 10 cross cross VB cord-300360-h6gr91eg 117 11 epithelial epithelial JJ cord-300360-h6gr91eg 117 12 cell cell NN cord-300360-h6gr91eg 117 13 layers layer NNS cord-300360-h6gr91eg 117 14 Phage phage NN cord-300360-h6gr91eg 117 15 penetration penetration NN cord-300360-h6gr91eg 117 16 of of IN cord-300360-h6gr91eg 117 17 eukaryotic eukaryotic JJ cord-300360-h6gr91eg 117 18 cells cell NNS cord-300360-h6gr91eg 117 19 : : : cord-300360-h6gr91eg 117 20 practical practical JJ cord-300360-h6gr91eg 117 21 implications implication NNS cord-300360-h6gr91eg 118 1 Phage phage NN cord-300360-h6gr91eg 118 2 therapy therapy NN cord-300360-h6gr91eg 118 3 for for IN cord-300360-h6gr91eg 118 4 limb limb NN cord-300360-h6gr91eg 118 5 - - HYPH cord-300360-h6gr91eg 118 6 threatening threaten VBG cord-300360-h6gr91eg 118 7 prosthetic prosthetic JJ cord-300360-h6gr91eg 118 8 knee knee NN cord-300360-h6gr91eg 118 9 Klebsiella Klebsiella NNP cord-300360-h6gr91eg 118 10 pneumoniae pneumoniae NN cord-300360-h6gr91eg 118 11 infection infection NN cord-300360-h6gr91eg 118 12 : : : cord-300360-h6gr91eg 119 1 case case NNP cord-300360-h6gr91eg 119 2 report report NN cord-300360-h6gr91eg 119 3 and and CC cord-300360-h6gr91eg 119 4 in in IN cord-300360-h6gr91eg 119 5 vitro vitro FW cord-300360-h6gr91eg 119 6 characterization characterization NN cord-300360-h6gr91eg 119 7 of of IN cord-300360-h6gr91eg 119 8 anti anti JJ cord-300360-h6gr91eg 119 9 - - JJ cord-300360-h6gr91eg 119 10 biofilm biofilm JJ cord-300360-h6gr91eg 119 11 activity activity NN cord-300360-h6gr91eg 119 12 T4 T4 NNP cord-300360-h6gr91eg 119 13 bacteriophage bacteriophage NN cord-300360-h6gr91eg 119 14 - - HYPH cord-300360-h6gr91eg 119 15 mediated mediate VBN cord-300360-h6gr91eg 119 16 inhibition inhibition NN cord-300360-h6gr91eg 119 17 of of IN cord-300360-h6gr91eg 119 18 adsorption adsorption NN cord-300360-h6gr91eg 119 19 and and CC cord-300360-h6gr91eg 119 20 replication replication NN cord-300360-h6gr91eg 119 21 of of IN cord-300360-h6gr91eg 119 22 human human JJ cord-300360-h6gr91eg 119 23 adenovirus adenovirus NN cord-300360-h6gr91eg 119 24 in in IN cord-300360-h6gr91eg 119 25 vitro vitro FW cord-300360-h6gr91eg 119 26 The the DT cord-300360-h6gr91eg 119 27 KGD KGD NNP cord-300360-h6gr91eg 119 28 motif motif NN cord-300360-h6gr91eg 119 29 of of IN cord-300360-h6gr91eg 119 30 Epstein Epstein NNP cord-300360-h6gr91eg 119 31 - - HYPH cord-300360-h6gr91eg 119 32 Barr Barr NNP cord-300360-h6gr91eg 119 33 virus virus NN cord-300360-h6gr91eg 119 34 gH gH NNP cord-300360-h6gr91eg 119 35 / / SYM cord-300360-h6gr91eg 119 36 gl gl NNP cord-300360-h6gr91eg 119 37 is be VBZ cord-300360-h6gr91eg 119 38 bifunctional bifunctional JJ cord-300360-h6gr91eg 119 39 , , , cord-300360-h6gr91eg 119 40 orchestrating orchestrate VBG cord-300360-h6gr91eg 119 41 infection infection NN cord-300360-h6gr91eg 119 42 of of IN cord-300360-h6gr91eg 119 43 B b NN cord-300360-h6gr91eg 119 44 cells cell NNS cord-300360-h6gr91eg 119 45 and and CC cord-300360-h6gr91eg 119 46 epithelial epithelial JJ cord-300360-h6gr91eg 119 47 cells cell NNS cord-300360-h6gr91eg 120 1 Perspectives perspective NNS cord-300360-h6gr91eg 120 2 of of IN cord-300360-h6gr91eg 120 3 phage phage NN cord-300360-h6gr91eg 120 4 - - HYPH cord-300360-h6gr91eg 120 5 eukaryotic eukaryotic JJ cord-300360-h6gr91eg 120 6 cell cell NN cord-300360-h6gr91eg 120 7 interactions interaction NNS cord-300360-h6gr91eg 120 8 to to TO cord-300360-h6gr91eg 120 9 control control VB cord-300360-h6gr91eg 120 10 Epstein Epstein NNP cord-300360-h6gr91eg 120 11 - - HYPH cord-300360-h6gr91eg 120 12 Barr Barr NNP cord-300360-h6gr91eg 120 13 virus virus NN cord-300360-h6gr91eg 120 14 infections infection NNS cord-300360-h6gr91eg 121 1 A a DT cord-300360-h6gr91eg 121 2 potential potential JJ cord-300360-h6gr91eg 121 3 inhibitory inhibitory JJ cord-300360-h6gr91eg 121 4 role role NN cord-300360-h6gr91eg 121 5 for for IN cord-300360-h6gr91eg 121 6 integrin integrin NN cord-300360-h6gr91eg 121 7 in in IN cord-300360-h6gr91eg 121 8 the the DT cord-300360-h6gr91eg 121 9 receptor receptor NN cord-300360-h6gr91eg 121 10 targeting target VBG cord-300360-h6gr91eg 121 11 of of IN cord-300360-h6gr91eg 121 12 SARS SARS NNP cord-300360-h6gr91eg 121 13 - - HYPH cord-300360-h6gr91eg 121 14 CoV-2 CoV-2 NNP cord-300360-h6gr91eg 121 15 Inhibitory inhibitory JJ cord-300360-h6gr91eg 121 16 effects effect NNS cord-300360-h6gr91eg 121 17 of of IN cord-300360-h6gr91eg 121 18 bacteriophage bacteriophage NN cord-300360-h6gr91eg 121 19 preparations preparation NNS cord-300360-h6gr91eg 121 20 on on IN cord-300360-h6gr91eg 121 21 adenoviral adenoviral JJ cord-300360-h6gr91eg 121 22 replication replication NN cord-300360-h6gr91eg 121 23 Perspectives perspective NNS cord-300360-h6gr91eg 121 24 of of IN cord-300360-h6gr91eg 121 25 phage phage NN cord-300360-h6gr91eg 121 26 therapy therapy NN cord-300360-h6gr91eg 121 27 in in IN cord-300360-h6gr91eg 121 28 non non JJ cord-300360-h6gr91eg 121 29 - - JJ cord-300360-h6gr91eg 121 30 bacterial bacterial JJ cord-300360-h6gr91eg 121 31 infections infection NNS cord-300360-h6gr91eg 122 1 Staphylococcus Staphylococcus NNP cord-300360-h6gr91eg 122 2 aureus aureus NN cord-300360-h6gr91eg 122 3 bacteriophage bacteriophage NN cord-300360-h6gr91eg 122 4 suppresses suppress VBZ cord-300360-h6gr91eg 122 5 LPS LPS NNP cord-300360-h6gr91eg 122 6 - - HYPH cord-300360-h6gr91eg 122 7 induced induce VBN cord-300360-h6gr91eg 122 8 inflammation inflammation NN cord-300360-h6gr91eg 122 9 in in IN cord-300360-h6gr91eg 122 10 MAC MAC NNP cord-300360-h6gr91eg 122 11 - - HYPH cord-300360-h6gr91eg 122 12 T T NNP cord-300360-h6gr91eg 122 13 bovine bovine JJ cord-300360-h6gr91eg 122 14 mammary mammary JJ cord-300360-h6gr91eg 122 15 epithelial epithelial JJ cord-300360-h6gr91eg 122 16 cells cell NNS cord-300360-h6gr91eg 122 17 Redox Redox NNP cord-300360-h6gr91eg 122 18 biology biology NN cord-300360-h6gr91eg 122 19 of of IN cord-300360-h6gr91eg 122 20 respiratory respiratory JJ cord-300360-h6gr91eg 122 21 viral viral JJ cord-300360-h6gr91eg 122 22 infections infection NNS cord-300360-h6gr91eg 122 23 Clinical clinical JJ cord-300360-h6gr91eg 122 24 course course NN cord-300360-h6gr91eg 122 25 and and CC cord-300360-h6gr91eg 122 26 outcomes outcome NNS cord-300360-h6gr91eg 122 27 of of IN cord-300360-h6gr91eg 122 28 patients patient NNS cord-300360-h6gr91eg 122 29 with with IN cord-300360-h6gr91eg 122 30 severe severe JJ cord-300360-h6gr91eg 122 31 acute acute JJ cord-300360-h6gr91eg 122 32 respiratory respiratory JJ cord-300360-h6gr91eg 122 33 syndrome syndrome NN cord-300360-h6gr91eg 122 34 coronavirus coronavirus NN cord-300360-h6gr91eg 122 35 2 2 CD cord-300360-h6gr91eg 122 36 infection infection NN cord-300360-h6gr91eg 122 37 : : : cord-300360-h6gr91eg 122 38 a a DT cord-300360-h6gr91eg 122 39 preliminary preliminary JJ cord-300360-h6gr91eg 122 40 report report NN cord-300360-h6gr91eg 122 41 of of IN cord-300360-h6gr91eg 122 42 the the DT cord-300360-h6gr91eg 122 43 first first JJ cord-300360-h6gr91eg 122 44 28 28 CD cord-300360-h6gr91eg 122 45 patients patient NNS cord-300360-h6gr91eg 122 46 from from IN cord-300360-h6gr91eg 122 47 the the DT cord-300360-h6gr91eg 122 48 Korean korean JJ cord-300360-h6gr91eg 122 49 cohort cohort NN cord-300360-h6gr91eg 122 50 study study NN cord-300360-h6gr91eg 122 51 on on IN cord-300360-h6gr91eg 122 52 COVID-19 COVID-19 NNP cord-300360-h6gr91eg 122 53 Oxidative oxidative JJ cord-300360-h6gr91eg 122 54 stress stress NN cord-300360-h6gr91eg 122 55 associated associate VBN cord-300360-h6gr91eg 122 56 with with IN cord-300360-h6gr91eg 122 57 SARS SARS NNP cord-300360-h6gr91eg 122 58 - - HYPH cord-300360-h6gr91eg 122 59 Cov-2 Cov-2 NNP cord-300360-h6gr91eg 122 60 ( ( -LRB- cord-300360-h6gr91eg 122 61 COVID-19 COVID-19 NNP cord-300360-h6gr91eg 122 62 ) ) -RRB- cord-300360-h6gr91eg 122 63 increases increase VBZ cord-300360-h6gr91eg 122 64 the the DT cord-300360-h6gr91eg 122 65 severity severity NN cord-300360-h6gr91eg 122 66 of of IN cord-300360-h6gr91eg 122 67 the the DT cord-300360-h6gr91eg 122 68 lung lung NN cord-300360-h6gr91eg 122 69 disease disease NN cord-300360-h6gr91eg 122 70 -a -a : cord-300360-h6gr91eg 122 71 systematic systematic JJ cord-300360-h6gr91eg 122 72 review review NN cord-300360-h6gr91eg 123 1 COVID-19 covid-19 JJ cord-300360-h6gr91eg 123 2 infection infection NN cord-300360-h6gr91eg 123 3 and and CC cord-300360-h6gr91eg 123 4 oxidative oxidative JJ cord-300360-h6gr91eg 123 5 stress stress NN cord-300360-h6gr91eg 123 6 : : : cord-300360-h6gr91eg 123 7 an an DT cord-300360-h6gr91eg 123 8 under under RB cord-300360-h6gr91eg 123 9 - - HYPH cord-300360-h6gr91eg 123 10 explored explore VBN cord-300360-h6gr91eg 123 11 approach approach NN cord-300360-h6gr91eg 123 12 for for IN cord-300360-h6gr91eg 123 13 prevention prevention NN cord-300360-h6gr91eg 123 14 and and CC cord-300360-h6gr91eg 123 15 treatment treatment NN cord-300360-h6gr91eg 123 16 ? ? . cord-300360-h6gr91eg 124 1 Ability ability NN cord-300360-h6gr91eg 124 2 of of IN cord-300360-h6gr91eg 124 3 human human JJ cord-300360-h6gr91eg 124 4 polymorhonuclear polymorhonuclear NN cord-300360-h6gr91eg 124 5 blood blood NN cord-300360-h6gr91eg 124 6 cells cell NNS cord-300360-h6gr91eg 124 7 to to TO cord-300360-h6gr91eg 124 8 produce produce VB cord-300360-h6gr91eg 124 9 interferon interferon NN cord-300360-h6gr91eg 124 10 after after IN cord-300360-h6gr91eg 124 11 induction induction NN cord-300360-h6gr91eg 124 12 with with IN cord-300360-h6gr91eg 124 13 phage phage NN cord-300360-h6gr91eg 124 14 double double RB cord-300360-h6gr91eg 124 15 - - HYPH cord-300360-h6gr91eg 124 16 stranded strand VBN cord-300360-h6gr91eg 124 17 RNA RNA NNP cord-300360-h6gr91eg 124 18 Bacteriophage Bacteriophage NNP cord-300360-h6gr91eg 124 19 trigger trigger NN cord-300360-h6gr91eg 124 20 antiviral antiviral JJ cord-300360-h6gr91eg 124 21 immunity immunity NN cord-300360-h6gr91eg 124 22 and and CC cord-300360-h6gr91eg 124 23 prevent prevent VB cord-300360-h6gr91eg 124 24 clearance clearance NN cord-300360-h6gr91eg 124 25 of of IN cord-300360-h6gr91eg 124 26 bacterial bacterial JJ cord-300360-h6gr91eg 124 27 infection infection NN cord-300360-h6gr91eg 124 28 Phage phage NN cord-300360-h6gr91eg 124 29 therapy therapy NN cord-300360-h6gr91eg 124 30 of of IN cord-300360-h6gr91eg 124 31 pneumonia pneumonia NN cord-300360-h6gr91eg 124 32 is be VBZ cord-300360-h6gr91eg 124 33 not not RB cord-300360-h6gr91eg 124 34 associated associate VBN cord-300360-h6gr91eg 124 35 with with IN cord-300360-h6gr91eg 124 36 an an DT cord-300360-h6gr91eg 124 37 overstimulation overstimulation NN cord-300360-h6gr91eg 124 38 of of IN cord-300360-h6gr91eg 124 39 the the DT cord-300360-h6gr91eg 124 40 inflammatory inflammatory JJ cord-300360-h6gr91eg 124 41 response response NN cord-300360-h6gr91eg 124 42 compared compare VBN cord-300360-h6gr91eg 124 43 to to IN cord-300360-h6gr91eg 124 44 antibiotic antibiotic JJ cord-300360-h6gr91eg 124 45 treatment treatment NN cord-300360-h6gr91eg 124 46 in in IN cord-300360-h6gr91eg 124 47 mice mouse NNS cord-300360-h6gr91eg 124 48 Bacteriophage Bacteriophage NNP cord-300360-h6gr91eg 124 49 interactions interaction NNS cord-300360-h6gr91eg 124 50 with with IN cord-300360-h6gr91eg 124 51 mammalian mammalian JJ cord-300360-h6gr91eg 124 52 tissue tissue NN cord-300360-h6gr91eg 124 53 : : : cord-300360-h6gr91eg 125 1 therapeutic therapeutic JJ cord-300360-h6gr91eg 125 2 applications application NNS cord-300360-h6gr91eg 126 1 The the DT cord-300360-h6gr91eg 126 2 respiratory respiratory JJ cord-300360-h6gr91eg 126 3 virome virome NN cord-300360-h6gr91eg 126 4 and and CC cord-300360-h6gr91eg 126 5 exacerbations exacerbation NNS cord-300360-h6gr91eg 126 6 in in IN cord-300360-h6gr91eg 126 7 patients patient NNS cord-300360-h6gr91eg 126 8 with with IN cord-300360-h6gr91eg 126 9 chronic chronic JJ cord-300360-h6gr91eg 126 10 obstructive obstructive JJ cord-300360-h6gr91eg 126 11 pulmonary pulmonary JJ cord-300360-h6gr91eg 126 12 disease disease NN cord-300360-h6gr91eg 126 13 Expansion Expansion NNP cord-300360-h6gr91eg 126 14 of of IN cord-300360-h6gr91eg 126 15 bacteriophages bacteriophage NNS cord-300360-h6gr91eg 126 16 is be VBZ cord-300360-h6gr91eg 126 17 linked link VBN cord-300360-h6gr91eg 126 18 to to IN cord-300360-h6gr91eg 126 19 aggravated aggravated JJ cord-300360-h6gr91eg 126 20 intestinal intestinal JJ cord-300360-h6gr91eg 126 21 inflammation inflammation NN cord-300360-h6gr91eg 126 22 and and CC cord-300360-h6gr91eg 126 23 colitis colitis NN cord-300360-h6gr91eg 126 24 Direct direct JJ cord-300360-h6gr91eg 126 25 antiviral antiviral JJ cord-300360-h6gr91eg 126 26 mechanisms mechanism NNS cord-300360-h6gr91eg 126 27 of of IN cord-300360-h6gr91eg 126 28 interferon interferon NN cord-300360-h6gr91eg 126 29 - - HYPH cord-300360-h6gr91eg 126 30 gamma gamma NN cord-300360-h6gr91eg 126 31 Trials trial NNS cord-300360-h6gr91eg 126 32 of of IN cord-300360-h6gr91eg 126 33 anti anti JJ cord-300360-h6gr91eg 126 34 - - JJ cord-300360-h6gr91eg 126 35 tumour tumour JJ cord-300360-h6gr91eg 126 36 necrosis necrosis NN cord-300360-h6gr91eg 126 37 factor factor NN cord-300360-h6gr91eg 126 38 therapy therapy NN cord-300360-h6gr91eg 126 39 for for IN cord-300360-h6gr91eg 126 40 COVID-19 COVID-19 NNP cord-300360-h6gr91eg 126 41 are be VBP cord-300360-h6gr91eg 126 42 urgently urgently RB cord-300360-h6gr91eg 126 43 needed need VBN cord-300360-h6gr91eg 126 44 Efficacy Efficacy NNP cord-300360-h6gr91eg 126 45 of of IN cord-300360-h6gr91eg 126 46 ϕkm18p ϕkm18p NNP cord-300360-h6gr91eg 126 47 phage phage NN cord-300360-h6gr91eg 126 48 therapy therapy NN cord-300360-h6gr91eg 126 49 in in IN cord-300360-h6gr91eg 126 50 a a DT cord-300360-h6gr91eg 126 51 murine murine JJ cord-300360-h6gr91eg 126 52 model model NN cord-300360-h6gr91eg 126 53 of of IN cord-300360-h6gr91eg 126 54 extensively extensively RB cord-300360-h6gr91eg 126 55 drug drug NN cord-300360-h6gr91eg 126 56 - - HYPH cord-300360-h6gr91eg 126 57 resistant resistant JJ cord-300360-h6gr91eg 126 58 Acinetobacter Acinetobacter NNP cord-300360-h6gr91eg 126 59 baumannii baumannii NN cord-300360-h6gr91eg 126 60 infection infection NN cord-300360-h6gr91eg 126 61 Efficacy Efficacy NNP cord-300360-h6gr91eg 126 62 of of IN cord-300360-h6gr91eg 126 63 bacteriophage bacteriophage NN cord-300360-h6gr91eg 126 64 treatment treatment NN cord-300360-h6gr91eg 126 65 against against IN cord-300360-h6gr91eg 126 66 carbapenem carbapenem NNP cord-300360-h6gr91eg 126 67 - - HYPH cord-300360-h6gr91eg 126 68 resistant resistant JJ cord-300360-h6gr91eg 126 69 Acinetobacter Acinetobacter NNP cord-300360-h6gr91eg 126 70 baumannii baumannii NN cord-300360-h6gr91eg 126 71 in in IN cord-300360-h6gr91eg 126 72 Galleria Galleria NNP cord-300360-h6gr91eg 126 73 mellonella mellonella NNP cord-300360-h6gr91eg 126 74 larvae larva NNS cord-300360-h6gr91eg 126 75 and and CC cord-300360-h6gr91eg 126 76 a a DT cord-300360-h6gr91eg 126 77 mouse mouse NN cord-300360-h6gr91eg 126 78 model model NN cord-300360-h6gr91eg 126 79 of of IN cord-300360-h6gr91eg 126 80 acute acute JJ cord-300360-h6gr91eg 126 81 pneumonia pneumonia NN cord-300360-h6gr91eg 126 82 Bacteriophage Bacteriophage NNP cord-300360-h6gr91eg 126 83 therapy therapy NN cord-300360-h6gr91eg 126 84 of of IN cord-300360-h6gr91eg 126 85 bacterial bacterial JJ cord-300360-h6gr91eg 126 86 infections infection NNS cord-300360-h6gr91eg 126 87 : : : cord-300360-h6gr91eg 127 1 an an DT cord-300360-h6gr91eg 127 2 update update NN cord-300360-h6gr91eg 127 3 of of IN cord-300360-h6gr91eg 127 4 our -PRON- PRP$ cord-300360-h6gr91eg 127 5 Institute Institute NNP cord-300360-h6gr91eg 127 6 's 's POS cord-300360-h6gr91eg 127 7 experience experience NN cord-300360-h6gr91eg 127 8 Induction Induction NNP cord-300360-h6gr91eg 127 9 of of IN cord-300360-h6gr91eg 127 10 antiviral antiviral JJ cord-300360-h6gr91eg 127 11 immune immune JJ cord-300360-h6gr91eg 127 12 response response NN cord-300360-h6gr91eg 127 13 through through IN cord-300360-h6gr91eg 127 14 recognition recognition NN cord-300360-h6gr91eg 127 15 of of IN cord-300360-h6gr91eg 127 16 the the DT cord-300360-h6gr91eg 127 17 repeating repeat VBG cord-300360-h6gr91eg 127 18 subunit subunit NN cord-300360-h6gr91eg 127 19 pattern pattern NN cord-300360-h6gr91eg 127 20 of of IN cord-300360-h6gr91eg 127 21 viral viral JJ cord-300360-h6gr91eg 127 22 capsids capsid NNS cord-300360-h6gr91eg 127 23 is be VBZ cord-300360-h6gr91eg 127 24 toll toll NN cord-300360-h6gr91eg 127 25 - - HYPH cord-300360-h6gr91eg 127 26 like like JJ cord-300360-h6gr91eg 127 27 receptor receptor NN cord-300360-h6gr91eg 127 28 2 2 CD cord-300360-h6gr91eg 127 29 dependent dependent JJ cord-300360-h6gr91eg 127 30 The the DT cord-300360-h6gr91eg 127 31 effects effect NNS cord-300360-h6gr91eg 127 32 of of IN cord-300360-h6gr91eg 127 33 bacteriophages bacteriophage NNS cord-300360-h6gr91eg 127 34 on on IN cord-300360-h6gr91eg 127 35 the the DT cord-300360-h6gr91eg 127 36 expression expression NN cord-300360-h6gr91eg 127 37 of of IN cord-300360-h6gr91eg 127 38 immunologically immunologically RB cord-300360-h6gr91eg 127 39 important important JJ cord-300360-h6gr91eg 127 40 genes gene NNS cord-300360-h6gr91eg 127 41 in in IN cord-300360-h6gr91eg 127 42 CaCo2 CaCo2 NNP cord-300360-h6gr91eg 127 43 cells cell NNS cord-300360-h6gr91eg 127 44 Effect effect NN cord-300360-h6gr91eg 127 45 of of IN cord-300360-h6gr91eg 127 46 human human JJ cord-300360-h6gr91eg 127 47 beta beta NN cord-300360-h6gr91eg 127 48 defensin-2 defensin-2 NN cord-300360-h6gr91eg 127 49 in in IN cord-300360-h6gr91eg 127 50 epithelial epithelial JJ cord-300360-h6gr91eg 127 51 cell cell NN cord-300360-h6gr91eg 127 52 lines line NNS cord-300360-h6gr91eg 127 53 infected infect VBN cord-300360-h6gr91eg 127 54 with with IN cord-300360-h6gr91eg 127 55 respiratory respiratory JJ cord-300360-h6gr91eg 127 56 viruses virus NNS cord-300360-h6gr91eg 127 57 β β XX cord-300360-h6gr91eg 127 58 - - HYPH cord-300360-h6gr91eg 127 59 defensins defensins NNP cord-300360-h6gr91eg 127 60 : : : cord-300360-h6gr91eg 127 61 farming farm VBG cord-300360-h6gr91eg 127 62 the the DT cord-300360-h6gr91eg 127 63 microbiome microbiome NN cord-300360-h6gr91eg 127 64 for for IN cord-300360-h6gr91eg 127 65 homeostasis homeostasis NN cord-300360-h6gr91eg 127 66 and and CC cord-300360-h6gr91eg 127 67 health health NN cord-300360-h6gr91eg 127 68 Safety Safety NNP cord-300360-h6gr91eg 127 69 of of IN cord-300360-h6gr91eg 127 70 bacteriophage bacteriophage NN cord-300360-h6gr91eg 127 71 therapy therapy NN cord-300360-h6gr91eg 127 72 in in IN cord-300360-h6gr91eg 127 73 severe severe JJ cord-300360-h6gr91eg 127 74 Staphylococcus Staphylococcus NNP cord-300360-h6gr91eg 127 75 aureus aureus NN cord-300360-h6gr91eg 127 76 infection infection NN cord-300360-h6gr91eg 127 77 Phages phage NNS cord-300360-h6gr91eg 127 78 needed need VBD cord-300360-h6gr91eg 127 79 against against IN cord-300360-h6gr91eg 127 80 resistant resistant JJ cord-300360-h6gr91eg 127 81 bacteria bacteria NNS cord-300360-h6gr91eg 127 82 Phage Phage NNP cord-300360-h6gr91eg 127 83 therapy therapy NN cord-300360-h6gr91eg 127 84 in in IN cord-300360-h6gr91eg 127 85 ortopedic ortopedic NNP cord-300360-h6gr91eg 127 86 implant implant JJ cord-300360-h6gr91eg 127 87 - - HYPH cord-300360-h6gr91eg 127 88 associated associate VBN cord-300360-h6gr91eg 127 89 infections infection NNS cord-300360-h6gr91eg 127 90 Epub epub RB cord-300360-h6gr91eg 127 91 ahead ahead RB cord-300360-h6gr91eg 127 92 of of IN cord-300360-h6gr91eg 127 93 print print NN cord-300360-h6gr91eg 127 94 ) ) -RRB- cord-300360-h6gr91eg 127 95 future future JJ cord-300360-h6gr91eg 127 96 science science NN cord-300360-h6gr91eg 127 97 group group NN