id	sid	tid	token	lemma	pos
cord-299882-ee5wathm	1	1	key	key	NN
cord-299882-ee5wathm	1	2	:	:	:
cord-299882-ee5wathm	1	3	cord-299882-ee5wathm	cord-299882-ee5wathm	CD
cord-299882-ee5wathm	1	4	authors	author	NNS
cord-299882-ee5wathm	1	5	:	:	:
cord-299882-ee5wathm	1	6	Hsiehchen	Hsiehchen	NNP
cord-299882-ee5wathm	1	7	,	,	,
cord-299882-ee5wathm	1	8	David	David	NNP
cord-299882-ee5wathm	1	9	;	;	:
cord-299882-ee5wathm	1	10	Espinoza	Espinoza	NNP
cord-299882-ee5wathm	1	11	,	,	,
cord-299882-ee5wathm	1	12	Magdalena	Magdalena	NNP
cord-299882-ee5wathm	1	13	;	;	:
cord-299882-ee5wathm	1	14	Hsieh	Hsieh	NNP
cord-299882-ee5wathm	1	15	,	,	,
cord-299882-ee5wathm	1	16	Antony	Antony	NNP
cord-299882-ee5wathm	1	17	title	title	NN
cord-299882-ee5wathm	1	18	:	:	:
cord-299882-ee5wathm	2	1	Deficiencies	deficiency	NNS
cord-299882-ee5wathm	2	2	in	in	IN
cord-299882-ee5wathm	2	3	the	the	DT
cord-299882-ee5wathm	2	4	designs	design	NNS
cord-299882-ee5wathm	2	5	and	and	CC
cord-299882-ee5wathm	2	6	interventions	intervention	NNS
cord-299882-ee5wathm	2	7	of	of	IN
cord-299882-ee5wathm	2	8	COVID-19	covid-19	JJ
cord-299882-ee5wathm	2	9	clinical	clinical	JJ
cord-299882-ee5wathm	2	10	trials	trial	NNS
cord-299882-ee5wathm	2	11	date	date	NN
cord-299882-ee5wathm	2	12	:	:	:
cord-299882-ee5wathm	2	13	2020	2020	CD
cord-299882-ee5wathm	2	14	-	-	HYPH
cord-299882-ee5wathm	2	15	07	07	CD
cord-299882-ee5wathm	2	16	-	-	HYPH
cord-299882-ee5wathm	2	17	04	04	CD
cord-299882-ee5wathm	2	18	journal	journal	NN
cord-299882-ee5wathm	2	19	:	:	:
cord-299882-ee5wathm	3	1	Med	Med	NNP
cord-299882-ee5wathm	3	2	(	(	-LRB-
cord-299882-ee5wathm	3	3	N	N	NNP
cord-299882-ee5wathm	3	4	Y	Y	NNP
cord-299882-ee5wathm	3	5	)	)	-RRB-
cord-299882-ee5wathm	3	6	DOI	DOI	NNP
cord-299882-ee5wathm	3	7	:	:	:
cord-299882-ee5wathm	3	8	10.1016	10.1016	CD
cord-299882-ee5wathm	3	9	/	/	SYM
cord-299882-ee5wathm	3	10	j.medj.2020.06.007	j.medj.2020.06.007	NNP
cord-299882-ee5wathm	3	11	sha	sha	NNP
cord-299882-ee5wathm	3	12	:	:	:
cord-299882-ee5wathm	4	1	358bd2722bc3cc527146403a2c7573dba71c0a66	358bd2722bc3cc527146403a2c7573dba71c0a66	LS
cord-299882-ee5wathm	4	2	doc_id	doc_id	CD
cord-299882-ee5wathm	4	3	:	:	:
cord-299882-ee5wathm	5	1	299882	299882	CD
cord-299882-ee5wathm	5	2	cord_uid	cord_uid	NNS
cord-299882-ee5wathm	5	3	:	:	:
cord-299882-ee5wathm	5	4	ee5wathm	ee5wathm	.
cord-299882-ee5wathm	6	1	nan	nan	NNP
cord-299882-ee5wathm	7	1	The	the	DT
cord-299882-ee5wathm	7	2	coronavirus	coronavirus	NN
cord-299882-ee5wathm	7	3	disease	disease	NN
cord-299882-ee5wathm	7	4	2019	2019	CD
cord-299882-ee5wathm	7	5	(	(	-LRB-
cord-299882-ee5wathm	7	6	COVID-19	COVID-19	NNP
cord-299882-ee5wathm	7	7	)	)	-RRB-
cord-299882-ee5wathm	7	8	pandemic	pandemic	NN
cord-299882-ee5wathm	7	9	has	have	VBZ
cord-299882-ee5wathm	7	10	caused	cause	VBN
cord-299882-ee5wathm	7	11	an	an	DT
cord-299882-ee5wathm	7	12	unprecedented	unprecedented	JJ
cord-299882-ee5wathm	7	13	rush	rush	NN
cord-299882-ee5wathm	7	14	of	of	IN
cord-299882-ee5wathm	7	15	clinical	clinical	JJ
cord-299882-ee5wathm	7	16	investigations	investigation	NNS
cord-299882-ee5wathm	7	17	.	.	.
cord-299882-ee5wathm	8	1	However	however	RB
cord-299882-ee5wathm	8	2	,	,	,
cord-299882-ee5wathm	8	3	this	this	DT
cord-299882-ee5wathm	8	4	urgency	urgency	NN
cord-299882-ee5wathm	8	5	has	have	VBZ
cord-299882-ee5wathm	8	6	also	also	RB
cord-299882-ee5wathm	8	7	triggered	trigger	VBN
cord-299882-ee5wathm	8	8	concerns	concern	NNS
cord-299882-ee5wathm	8	9	regarding	regard	VBG
cord-299882-ee5wathm	8	10	the	the	DT
cord-299882-ee5wathm	8	11	quality	quality	NN
cord-299882-ee5wathm	8	12	of	of	IN
cord-299882-ee5wathm	8	13	evidence	evidence	NN
cord-299882-ee5wathm	8	14	being	be	VBG
cord-299882-ee5wathm	8	15	generated	generate	VBN
cord-299882-ee5wathm	8	16	.	.	.
cord-299882-ee5wathm	9	1	[	[	-LRB-
cord-299882-ee5wathm	9	2	1	1	CD
cord-299882-ee5wathm	9	3	]	]	-RRB-
cord-299882-ee5wathm	9	4	[	[	-LRB-
cord-299882-ee5wathm	9	5	2	2	CD
cord-299882-ee5wathm	9	6	]	]	-RRB-
cord-299882-ee5wathm	9	7	[	[	-LRB-
cord-299882-ee5wathm	9	8	3	3	CD
cord-299882-ee5wathm	9	9	]	]	-RRB-
cord-299882-ee5wathm	9	10	[	[	-LRB-
cord-299882-ee5wathm	9	11	4	4	CD
cord-299882-ee5wathm	9	12	]	]	-RRB-
cord-299882-ee5wathm	10	1	Particularly	particularly	RB
cord-299882-ee5wathm	10	2	concerning	concern	VBG
cord-299882-ee5wathm	10	3	is	be	VBZ
cord-299882-ee5wathm	10	4	that	that	IN
cord-299882-ee5wathm	10	5	the	the	DT
cord-299882-ee5wathm	10	6	dearth	dearth	NN
cord-299882-ee5wathm	10	7	of	of	IN
cord-299882-ee5wathm	10	8	high	high	JJ
cord-299882-ee5wathm	10	9	-	-	HYPH
cord-299882-ee5wathm	10	10	quality	quality	NN
cord-299882-ee5wathm	10	11	medical	medical	JJ
cord-299882-ee5wathm	10	12	evidence	evidence	NN
cord-299882-ee5wathm	10	13	has	have	VBZ
cord-299882-ee5wathm	10	14	contributed	contribute	VBN
cord-299882-ee5wathm	10	15	to	to	IN
cord-299882-ee5wathm	10	16	a	a	DT
cord-299882-ee5wathm	10	17	lack	lack	NN
cord-299882-ee5wathm	10	18	of	of	IN
cord-299882-ee5wathm	10	19	confidence	confidence	NN
cord-299882-ee5wathm	10	20	in	in	IN
cord-299882-ee5wathm	10	21	existing	exist	VBG
cord-299882-ee5wathm	10	22	guidelines	guideline	NNS
cord-299882-ee5wathm	10	23	on	on	IN
cord-299882-ee5wathm	10	24	COVID-19	COVID-19	NNP
cord-299882-ee5wathm	10	25	therapies	therapy	NNS
cord-299882-ee5wathm	10	26	,	,	,
cord-299882-ee5wathm	10	27	the	the	DT
cord-299882-ee5wathm	10	28	off	off	JJ
cord-299882-ee5wathm	10	29	-	-	HYPH
cord-299882-ee5wathm	10	30	label	label	NN
cord-299882-ee5wathm	10	31	use	use	NN
cord-299882-ee5wathm	10	32	of	of	IN
cord-299882-ee5wathm	10	33	unproven	unproven	JJ
cord-299882-ee5wathm	10	34	therapies	therapy	NNS
cord-299882-ee5wathm	10	35	by	by	IN
cord-299882-ee5wathm	10	36	patients	patient	NNS
cord-299882-ee5wathm	10	37	and	and	CC
cord-299882-ee5wathm	10	38	clinicians	clinician	NNS
cord-299882-ee5wathm	10	39	,	,	,
cord-299882-ee5wathm	10	40	and	and	CC
cord-299882-ee5wathm	10	41	predatory	predatory	JJ
cord-299882-ee5wathm	10	42	behaviors	behavior	NNS
cord-299882-ee5wathm	10	43	exploiting	exploit	VBG
cord-299882-ee5wathm	10	44	the	the	DT
cord-299882-ee5wathm	10	45	lack	lack	NN
cord-299882-ee5wathm	10	46	of	of	IN
cord-299882-ee5wathm	10	47	strong	strong	JJ
cord-299882-ee5wathm	10	48	scientific	scientific	JJ
cord-299882-ee5wathm	10	49	rationale	rationale	NN
cord-299882-ee5wathm	10	50	for	for	IN
cord-299882-ee5wathm	10	51	many	many	JJ
cord-299882-ee5wathm	10	52	tested	test	VBN
cord-299882-ee5wathm	10	53	interventions	intervention	NNS
cord-299882-ee5wathm	10	54	.	.	.
cord-299882-ee5wathm	11	1	3	3	CD
cord-299882-ee5wathm	11	2	,	,	,
cord-299882-ee5wathm	11	3	5	5	CD
cord-299882-ee5wathm	11	4	,	,	,
cord-299882-ee5wathm	11	5	6	6	CD
cord-299882-ee5wathm	11	6	Crucial	Crucial	NNP
cord-299882-ee5wathm	11	7	to	to	IN
cord-299882-ee5wathm	11	8	the	the	DT
cord-299882-ee5wathm	11	9	evaluation	evaluation	NN
cord-299882-ee5wathm	11	10	and	and	CC
cord-299882-ee5wathm	11	11	implementation	implementation	NN
cord-299882-ee5wathm	11	12	of	of	IN
cord-299882-ee5wathm	11	13	COVID-19	COVID-19	NNP
cord-299882-ee5wathm	11	14	interventions	intervention	NNS
cord-299882-ee5wathm	11	15	is	be	VBZ
cord-299882-ee5wathm	11	16	the	the	DT
cord-299882-ee5wathm	11	17	rigor	rigor	NN
cord-299882-ee5wathm	11	18	,	,	,
cord-299882-ee5wathm	11	19	quality	quality	NN
cord-299882-ee5wathm	11	20	,	,	,
cord-299882-ee5wathm	11	21	and	and	CC
cord-299882-ee5wathm	11	22	credibility	credibility	NN
cord-299882-ee5wathm	11	23	of	of	IN
cord-299882-ee5wathm	11	24	clinical	clinical	JJ
cord-299882-ee5wathm	11	25	trials	trial	NNS
cord-299882-ee5wathm	11	26	.	.	.
cord-299882-ee5wathm	12	1	We	-PRON-	PRP
cord-299882-ee5wathm	12	2	assess	assess	VBP
cord-299882-ee5wathm	12	3	these	these	DT
cord-299882-ee5wathm	12	4	characteristics	characteristic	NNS
cord-299882-ee5wathm	12	5	in	in	IN
cord-299882-ee5wathm	12	6	a	a	DT
cord-299882-ee5wathm	12	7	systematic	systematic	JJ
cord-299882-ee5wathm	12	8	analysis	analysis	NN
cord-299882-ee5wathm	12	9	of	of	IN
cord-299882-ee5wathm	12	10	all	all	DT
cord-299882-ee5wathm	12	11	registered	register	VBN
cord-299882-ee5wathm	12	12	interventional	interventional	JJ
cord-299882-ee5wathm	12	13	trials	trial	NNS
cord-299882-ee5wathm	12	14	on	on	IN
cord-299882-ee5wathm	12	15	COVID-19	COVID-19	NNP
cord-299882-ee5wathm	12	16	to	to	IN
cord-299882-ee5wathm	12	17	date	date	NN
cord-299882-ee5wathm	12	18	.	.	.
cord-299882-ee5wathm	13	1	We	-PRON-	PRP
cord-299882-ee5wathm	13	2	identified	identify	VBD
cord-299882-ee5wathm	13	3	all	all	DT
cord-299882-ee5wathm	13	4	interventional	interventional	JJ
cord-299882-ee5wathm	13	5	trials	trial	NNS
cord-299882-ee5wathm	13	6	registered	register	VBN
cord-299882-ee5wathm	13	7	up	up	RP
cord-299882-ee5wathm	13	8	to	to	IN
cord-299882-ee5wathm	13	9	5/5/20	5/5/20	CD
cord-299882-ee5wathm	13	10	from	from	IN
cord-299882-ee5wathm	13	11	the	the	DT
cord-299882-ee5wathm	13	12	WHO	WHO	NNP
cord-299882-ee5wathm	13	13	International	International	NNP
cord-299882-ee5wathm	13	14	Clinical	Clinical	NNP
cord-299882-ee5wathm	13	15	Trials	Trials	NNPS
cord-299882-ee5wathm	13	16	Registry	Registry	NNP
cord-299882-ee5wathm	13	17	and	and	CC
cord-299882-ee5wathm	13	18	the	the	DT
cord-299882-ee5wathm	13	19	Global	Global	NNP
cord-299882-ee5wathm	13	20	Coronavirus	Coronavirus	NNP
cord-299882-ee5wathm	13	21	COVID-19	COVID-19	NNP
cord-299882-ee5wathm	13	22	Clinical	Clinical	NNP
cord-299882-ee5wathm	13	23	Trial	Trial	NNP
cord-299882-ee5wathm	13	24	Tracker	Tracker	NNP
cord-299882-ee5wathm	13	25	.	.	.
cord-299882-ee5wathm	14	1	Trials	trial	NNS
cord-299882-ee5wathm	14	2	were	be	VBD
cord-299882-ee5wathm	14	3	manually	manually	RB
cord-299882-ee5wathm	14	4	reviewed	review	VBN
cord-299882-ee5wathm	14	5	to	to	TO
cord-299882-ee5wathm	14	6	exclude	exclude	VB
cord-299882-ee5wathm	14	7	non	non	JJ
cord-299882-ee5wathm	14	8	-	-	JJ
cord-299882-ee5wathm	14	9	interventional	interventional	JJ
cord-299882-ee5wathm	14	10	trials	trial	NNS
cord-299882-ee5wathm	14	11	and	and	CC
cord-299882-ee5wathm	14	12	duplicate	duplicate	VB
cord-299882-ee5wathm	14	13	entries	entry	NNS
cord-299882-ee5wathm	14	14	.	.	.
cord-299882-ee5wathm	15	1	Additional	additional	JJ
cord-299882-ee5wathm	15	2	trial	trial	NN
cord-299882-ee5wathm	15	3	characteristics	characteristic	NNS
cord-299882-ee5wathm	15	4	were	be	VBD
cord-299882-ee5wathm	15	5	abstracted	abstract	VBN
cord-299882-ee5wathm	15	6	from	from	IN
cord-299882-ee5wathm	15	7	individual	individual	JJ
cord-299882-ee5wathm	15	8	trial	trial	NN
cord-299882-ee5wathm	15	9	registries	registry	NNS
cord-299882-ee5wathm	15	10	from	from	IN
cord-299882-ee5wathm	15	11	the	the	DT
cord-299882-ee5wathm	15	12	European	European	NNP
cord-299882-ee5wathm	15	13	Union	Union	NNP
cord-299882-ee5wathm	15	14	,	,	,
cord-299882-ee5wathm	15	15	Australia	Australia	NNP
cord-299882-ee5wathm	15	16	/	/	SYM
cord-299882-ee5wathm	15	17	New	New	NNP
cord-299882-ee5wathm	15	18	Zealand	Zealand	NNP
cord-299882-ee5wathm	15	19	,	,	,
cord-299882-ee5wathm	15	20	China	China	NNP
cord-299882-ee5wathm	15	21	,	,	,
cord-299882-ee5wathm	15	22	India	India	NNP
cord-299882-ee5wathm	15	23	,	,	,
cord-299882-ee5wathm	15	24	Germany	Germany	NNP
cord-299882-ee5wathm	15	25	,	,	,
cord-299882-ee5wathm	15	26	Iran	Iran	NNP
cord-299882-ee5wathm	15	27	,	,	,
cord-299882-ee5wathm	15	28	Japan	Japan	NNP
cord-299882-ee5wathm	15	29	,	,	,
cord-299882-ee5wathm	15	30	Netherlands	Netherlands	NNP
cord-299882-ee5wathm	15	31	,	,	,
cord-299882-ee5wathm	15	32	Cuba	Cuba	NNP
cord-299882-ee5wathm	15	33	,	,	,
cord-299882-ee5wathm	15	34	Thailand	Thailand	NNP
cord-299882-ee5wathm	15	35	,	,	,
cord-299882-ee5wathm	15	36	ISRCTN	ISRCTN	NNP
cord-299882-ee5wathm	15	37	,	,	,
cord-299882-ee5wathm	15	38	and	and	CC
cord-299882-ee5wathm	15	39	clinicaltrials.gov	clinicaltrials.gov	NNP
cord-299882-ee5wathm	15	40	.	.	.
cord-299882-ee5wathm	16	1	Characteristics	characteristic	NNS
cord-299882-ee5wathm	16	2	of	of	IN
cord-299882-ee5wathm	16	3	1,029	1,029	CD
cord-299882-ee5wathm	16	4	interventional	interventional	JJ
cord-299882-ee5wathm	16	5	trials	trial	NNS
cord-299882-ee5wathm	16	6	registered	register	VBN
cord-299882-ee5wathm	16	7	between	between	IN
cord-299882-ee5wathm	16	8	1/23/2020	1/23/2020	CD
cord-299882-ee5wathm	16	9	and	and	CC
cord-299882-ee5wathm	16	10	5/5/2020	5/5/2020	CD
cord-299882-ee5wathm	16	11	organized	organize	VBN
cord-299882-ee5wathm	16	12	by	by	IN
cord-299882-ee5wathm	16	13	country	country	NN
cord-299882-ee5wathm	16	14	or	or	CC
cord-299882-ee5wathm	16	15	region	region	NN
cord-299882-ee5wathm	16	16	are	be	VBP
cord-299882-ee5wathm	16	17	shown	show	VBN
cord-299882-ee5wathm	16	18	in	in	IN
cord-299882-ee5wathm	16	19	Supplementary	Supplementary	NNP
cord-299882-ee5wathm	16	20	Table	Table	NNP
cord-299882-ee5wathm	16	21	1	1	CD
cord-299882-ee5wathm	16	22	.	.	.
cord-299882-ee5wathm	17	1	The	the	DT
cord-299882-ee5wathm	17	2	top	top	JJ
cord-299882-ee5wathm	17	3	countries	country	NNS
cord-299882-ee5wathm	17	4	by	by	IN
cord-299882-ee5wathm	17	5	registered	register	VBN
cord-299882-ee5wathm	17	6	trials	trial	NNS
cord-299882-ee5wathm	17	7	were	be	VBD
cord-299882-ee5wathm	17	8	China	China	NNP
cord-299882-ee5wathm	17	9	(	(	-LRB-
cord-299882-ee5wathm	17	10	337	337	CD
cord-299882-ee5wathm	17	11	)	)	-RRB-
cord-299882-ee5wathm	17	12	,	,	,
cord-299882-ee5wathm	17	13	US	US	NNP
cord-299882-ee5wathm	17	14	(	(	-LRB-
cord-299882-ee5wathm	17	15	185	185	CD
cord-299882-ee5wathm	17	16	)	)	-RRB-
cord-299882-ee5wathm	17	17	,	,	,
cord-299882-ee5wathm	17	18	and	and	CC
cord-299882-ee5wathm	17	19	Iran	Iran	NNP
cord-299882-ee5wathm	17	20	(	(	-LRB-
cord-299882-ee5wathm	17	21	117	117	CD
cord-299882-ee5wathm	17	22	)	)	-RRB-
cord-299882-ee5wathm	17	23	.	.	.
cord-299882-ee5wathm	18	1	Most	Most	JJS
cord-299882-ee5wathm	18	2	trials	trial	NNS
cord-299882-ee5wathm	18	3	tested	test	VBD
cord-299882-ee5wathm	18	4	treatments	treatment	NNS
cord-299882-ee5wathm	18	5	(	(	-LRB-
cord-299882-ee5wathm	18	6	93	93	CD
cord-299882-ee5wathm	18	7	%	%	NN
cord-299882-ee5wathm	18	8	)	)	-RRB-
cord-299882-ee5wathm	18	9	,	,	,
cord-299882-ee5wathm	18	10	planned	plan	VBN
cord-299882-ee5wathm	18	11	to	to	TO
cord-299882-ee5wathm	18	12	enroll	enroll	VB
cord-299882-ee5wathm	18	13	less	less	JJR
cord-299882-ee5wathm	18	14	than	than	IN
cord-299882-ee5wathm	18	15	1000	1000	CD
cord-299882-ee5wathm	18	16	patients	patient	NNS
cord-299882-ee5wathm	18	17	(	(	-LRB-
cord-299882-ee5wathm	18	18	88	88	CD
cord-299882-ee5wathm	18	19	%	%	NN
cord-299882-ee5wathm	18	20	)	)	-RRB-
cord-299882-ee5wathm	18	21	,	,	,
cord-299882-ee5wathm	18	22	included	include	VBD
cord-299882-ee5wathm	18	23	hospitalized	hospitalize	VBN
cord-299882-ee5wathm	18	24	patients	patient	NNS
cord-299882-ee5wathm	18	25	(	(	-LRB-
cord-299882-ee5wathm	18	26	71.8	71.8	CD
cord-299882-ee5wathm	18	27	%	%	NN
cord-299882-ee5wathm	18	28	)	)	-RRB-
cord-299882-ee5wathm	18	29	,	,	,
cord-299882-ee5wathm	18	30	and	and	CC
cord-299882-ee5wathm	18	31	were	be	VBD
cord-299882-ee5wathm	18	32	early	early	JJ
cord-299882-ee5wathm	18	33	phase	phase	NN
cord-299882-ee5wathm	18	34	studies	study	NNS
cord-299882-ee5wathm	18	35	(	(	-LRB-
cord-299882-ee5wathm	18	36	58.6	58.6	CD
cord-299882-ee5wathm	18	37	%	%	NN
cord-299882-ee5wathm	18	38	)	)	-RRB-
cord-299882-ee5wathm	18	39	.	.	.
cord-299882-ee5wathm	19	1	Trials	trial	NNS
cord-299882-ee5wathm	19	2	were	be	VBD
cord-299882-ee5wathm	19	3	often	often	RB
cord-299882-ee5wathm	19	4	single	single	JJ
cord-299882-ee5wathm	19	5	-	-	HYPH
cord-299882-ee5wathm	19	6	center	center	NN
cord-299882-ee5wathm	19	7	(	(	-LRB-
cord-299882-ee5wathm	19	8	64.4	64.4	CD
cord-299882-ee5wathm	19	9	%	%	NN
cord-299882-ee5wathm	19	10	)	)	-RRB-
cord-299882-ee5wathm	19	11	,	,	,
cord-299882-ee5wathm	19	12	randomized	randomize	VBN
cord-299882-ee5wathm	19	13	(	(	-LRB-
cord-299882-ee5wathm	19	14	78	78	CD
cord-299882-ee5wathm	19	15	%	%	NN
cord-299882-ee5wathm	19	16	)	)	-RRB-
cord-299882-ee5wathm	19	17	and	and	CC
cord-299882-ee5wathm	19	18	open	open	JJ
cord-299882-ee5wathm	19	19	-	-	HYPH
cord-299882-ee5wathm	19	20	label	label	NN
cord-299882-ee5wathm	19	21	(	(	-LRB-
cord-299882-ee5wathm	19	22	59.9	59.9	CD
cord-299882-ee5wathm	19	23	%	%	NN
cord-299882-ee5wathm	19	24	)	)	-RRB-
cord-299882-ee5wathm	19	25	.	.	.
cord-299882-ee5wathm	20	1	Placebo	placebo	NN
cord-299882-ee5wathm	20	2	comparisons	comparison	NNS
cord-299882-ee5wathm	20	3	were	be	VBD
cord-299882-ee5wathm	20	4	infrequent	infrequent	JJ
cord-299882-ee5wathm	20	5	(	(	-LRB-
cord-299882-ee5wathm	20	6	24.2	24.2	CD
cord-299882-ee5wathm	20	7	%	%	NN
cord-299882-ee5wathm	20	8	)	)	-RRB-
cord-299882-ee5wathm	20	9	,	,	,
cord-299882-ee5wathm	20	10	and	and	CC
cord-299882-ee5wathm	20	11	trials	trial	NNS
cord-299882-ee5wathm	20	12	rarely	rarely	RB
cord-299882-ee5wathm	20	13	excluded	exclude	VBN
cord-299882-ee5wathm	20	14	prior	prior	RB
cord-299882-ee5wathm	20	15	or	or	CC
cord-299882-ee5wathm	20	16	concurrent	concurrent	JJ
cord-299882-ee5wathm	20	17	use	use	NN
cord-299882-ee5wathm	20	18	of	of	IN
cord-299882-ee5wathm	20	19	hydroxychloroquine	hydroxychloroquine	NN
cord-299882-ee5wathm	20	20	/	/	SYM
cord-299882-ee5wathm	20	21	chloroquine	chloroquine	NN
cord-299882-ee5wathm	20	22	(	(	-LRB-
cord-299882-ee5wathm	20	23	7.9	7.9	CD
cord-299882-ee5wathm	20	24	%	%	NN
cord-299882-ee5wathm	20	25	)	)	-RRB-
cord-299882-ee5wathm	20	26	,	,	,
cord-299882-ee5wathm	20	27	or	or	CC
cord-299882-ee5wathm	20	28	non	non	JJ
cord-299882-ee5wathm	20	29	-	-	JJ
cord-299882-ee5wathm	20	30	study	study	JJ
cord-299882-ee5wathm	20	31	antiviral	antiviral	JJ
cord-299882-ee5wathm	20	32	agents	agent	NNS
cord-299882-ee5wathm	20	33	(	(	-LRB-
cord-299882-ee5wathm	20	34	3.6	3.6	CD
cord-299882-ee5wathm	20	35	%	%	NN
cord-299882-ee5wathm	20	36	)	)	-RRB-
cord-299882-ee5wathm	20	37	based	base	VBN
cord-299882-ee5wathm	20	38	on	on	IN
cord-299882-ee5wathm	20	39	stated	state	VBN
cord-299882-ee5wathm	20	40	inclusion	inclusion	NN
cord-299882-ee5wathm	20	41	and	and	CC
cord-299882-ee5wathm	20	42	exclusion	exclusion	NN
cord-299882-ee5wathm	20	43	criteria	criterion	NNS
cord-299882-ee5wathm	20	44	.	.	.
cord-299882-ee5wathm	21	1	Trial	trial	NN
cord-299882-ee5wathm	21	2	characteristics	characteristic	NNS
cord-299882-ee5wathm	21	3	differed	differ	VBN
cord-299882-ee5wathm	21	4	by	by	IN
cord-299882-ee5wathm	21	5	geography	geography	NN
cord-299882-ee5wathm	21	6	.	.	.
cord-299882-ee5wathm	22	1	European	european	JJ
cord-299882-ee5wathm	22	2	trials	trial	NNS
cord-299882-ee5wathm	22	3	had	have	VBD
cord-299882-ee5wathm	22	4	larger	large	JJR
cord-299882-ee5wathm	22	5	enrollments	enrollment	NNS
cord-299882-ee5wathm	22	6	,	,	,
cord-299882-ee5wathm	22	7	multiple	multiple	JJ
cord-299882-ee5wathm	22	8	sites	site	NNS
cord-299882-ee5wathm	22	9	,	,	,
cord-299882-ee5wathm	22	10	and	and	CC
cord-299882-ee5wathm	22	11	more	more	JJR
cord-299882-ee5wathm	22	12	than	than	IN
cord-299882-ee5wathm	22	13	3	3	CD
cord-299882-ee5wathm	22	14	arms	arm	NNS
cord-299882-ee5wathm	22	15	.	.	.
cord-299882-ee5wathm	23	1	US	US	NNP
cord-299882-ee5wathm	23	2	trials	trial	NNS
cord-299882-ee5wathm	23	3	tested	test	VBD
cord-299882-ee5wathm	23	4	more	more	JJR
cord-299882-ee5wathm	23	5	prevention	prevention	NN
cord-299882-ee5wathm	23	6	interventions	intervention	NNS
cord-299882-ee5wathm	23	7	,	,	,
cord-299882-ee5wathm	23	8	enrolled	enrol	VBD
cord-299882-ee5wathm	23	9	healthcare	healthcare	NN
cord-299882-ee5wathm	23	10	workers	worker	NNS
cord-299882-ee5wathm	23	11	,	,	,
cord-299882-ee5wathm	23	12	applied	apply	VBD
cord-299882-ee5wathm	23	13	blinding	blind	VBG
cord-299882-ee5wathm	23	14	,	,	,
cord-299882-ee5wathm	23	15	used	use	VBD
cord-299882-ee5wathm	23	16	placebos	placebo	NNS
cord-299882-ee5wathm	23	17	,	,	,
cord-299882-ee5wathm	23	18	had	have	VBD
cord-299882-ee5wathm	23	19	industry	industry	NN
cord-299882-ee5wathm	23	20	sponsors	sponsor	NNS
cord-299882-ee5wathm	23	21	,	,	,
cord-299882-ee5wathm	23	22	and	and	CC
cord-299882-ee5wathm	23	23	included	include	VBD
cord-299882-ee5wathm	23	24	international	international	JJ
cord-299882-ee5wathm	23	25	sites	site	NNS
cord-299882-ee5wathm	23	26	.	.	.
cord-299882-ee5wathm	24	1	China	China	NNP
cord-299882-ee5wathm	24	2	and	and	CC
cord-299882-ee5wathm	24	3	Iran	Iran	NNP
cord-299882-ee5wathm	24	4	trials	trial	NNS
cord-299882-ee5wathm	24	5	were	be	VBD
cord-299882-ee5wathm	24	6	associated	associate	VBN
cord-299882-ee5wathm	24	7	with	with	IN
cord-299882-ee5wathm	24	8	smaller	small	JJR
cord-299882-ee5wathm	24	9	enrollments	enrollment	NNS
cord-299882-ee5wathm	24	10	,	,	,
cord-299882-ee5wathm	24	11	single	single	JJ
cord-299882-ee5wathm	24	12	-	-	HYPH
cord-299882-ee5wathm	24	13	center	center	NN
cord-299882-ee5wathm	24	14	enrollment	enrollment	NN
cord-299882-ee5wathm	24	15	,	,	,
cord-299882-ee5wathm	24	16	testing	testing	NN
cord-299882-ee5wathm	24	17	of	of	IN
cord-299882-ee5wathm	24	18	Traditional	traditional	JJ
cord-299882-ee5wathm	24	19	medicines	medicine	NNS
cord-299882-ee5wathm	24	20	,	,	,
cord-299882-ee5wathm	24	21	and	and	CC
cord-299882-ee5wathm	24	22	rare	rare	JJ
cord-299882-ee5wathm	24	23	international	international	JJ
cord-299882-ee5wathm	24	24	collaborations	collaboration	NNS
cord-299882-ee5wathm	24	25	.	.	.
cord-299882-ee5wathm	25	1	Of	of	IN
cord-299882-ee5wathm	25	2	note	note	VB
cord-299882-ee5wathm	25	3	,	,	,
cord-299882-ee5wathm	25	4	many	many	JJ
cord-299882-ee5wathm	25	5	clinical	clinical	JJ
cord-299882-ee5wathm	25	6	trials	trial	NNS
cord-299882-ee5wathm	25	7	in	in	IN
cord-299882-ee5wathm	25	8	China	China	NNP
cord-299882-ee5wathm	25	9	were	be	VBD
cord-299882-ee5wathm	25	10	registered	register	VBN
cord-299882-ee5wathm	25	11	prior	prior	RB
cord-299882-ee5wathm	25	12	to	to	IN
cord-299882-ee5wathm	25	13	the	the	DT
cord-299882-ee5wathm	25	14	spread	spread	NN
cord-299882-ee5wathm	25	15	of	of	IN
cord-299882-ee5wathm	25	16	the	the	DT
cord-299882-ee5wathm	25	17	pandemic	pandemic	NN
cord-299882-ee5wathm	25	18	beyond	beyond	IN
cord-299882-ee5wathm	25	19	China	China	NNP
cord-299882-ee5wathm	25	20	and	and	CC
cord-299882-ee5wathm	25	21	neighboring	neighboring	NN
cord-299882-ee5wathm	25	22	countries	country	NNS
cord-299882-ee5wathm	25	23	,	,	,
cord-299882-ee5wathm	25	24	likely	likely	RB
cord-299882-ee5wathm	25	25	making	make	VBG
cord-299882-ee5wathm	25	26	it	-PRON-	PRP
cord-299882-ee5wathm	25	27	difficult	difficult	JJ
cord-299882-ee5wathm	25	28	to	to	TO
cord-299882-ee5wathm	25	29	involve	involve	VB
cord-299882-ee5wathm	25	30	international	international	JJ
cord-299882-ee5wathm	25	31	sites	site	NNS
cord-299882-ee5wathm	25	32	.	.	.
cord-299882-ee5wathm	26	1	Iran	Iran	NNP
cord-299882-ee5wathm	26	2	's	's	POS
cord-299882-ee5wathm	26	3	strained	strained	JJ
cord-299882-ee5wathm	26	4	international	international	JJ
cord-299882-ee5wathm	26	5	political	political	JJ
cord-299882-ee5wathm	26	6	relations	relation	NNS
cord-299882-ee5wathm	26	7	to	to	IN
cord-299882-ee5wathm	26	8	other	other	JJ
cord-299882-ee5wathm	26	9	countries	country	NNS
cord-299882-ee5wathm	26	10	including	include	VBG
cord-299882-ee5wathm	26	11	sanctions	sanction	NNS
cord-299882-ee5wathm	26	12	likely	likely	RB
cord-299882-ee5wathm	26	13	affects	affect	VBZ
cord-299882-ee5wathm	26	14	its	-PRON-	PRP$
cord-299882-ee5wathm	26	15	ability	ability	NN
cord-299882-ee5wathm	26	16	to	to	TO
cord-299882-ee5wathm	26	17	create	create	VB
cord-299882-ee5wathm	26	18	clinical	clinical	JJ
cord-299882-ee5wathm	26	19	studies	study	NNS
cord-299882-ee5wathm	26	20	including	include	VBG
cord-299882-ee5wathm	26	21	other	other	JJ
cord-299882-ee5wathm	26	22	countries	country	NNS
cord-299882-ee5wathm	26	23	.	.	.
cord-299882-ee5wathm	27	1	Supplementary	Supplementary	NNP
cord-299882-ee5wathm	27	2	Figure	Figure	NNP
cord-299882-ee5wathm	27	3	1A	1a	NN
cord-299882-ee5wathm	27	4	and	and	CC
cord-299882-ee5wathm	27	5	1B	1b	CD
cord-299882-ee5wathm	27	6	show	show	VBP
cord-299882-ee5wathm	27	7	a	a	DT
cord-299882-ee5wathm	27	8	positive	positive	JJ
cord-299882-ee5wathm	27	9	and	and	CC
cord-299882-ee5wathm	27	10	significant	significant	JJ
cord-299882-ee5wathm	27	11	correlation	correlation	NN
cord-299882-ee5wathm	27	12	between	between	IN
cord-299882-ee5wathm	27	13	trials	trial	NNS
cord-299882-ee5wathm	27	14	and	and	CC
cord-299882-ee5wathm	27	15	COVID-19	covid-19	JJ
cord-299882-ee5wathm	27	16	infections	infection	NNS
cord-299882-ee5wathm	27	17	and	and	CC
cord-299882-ee5wathm	27	18	deaths	death	NNS
cord-299882-ee5wathm	28	1	(	(	-LRB-
cord-299882-ee5wathm	28	2	Spearman	Spearman	NNP
cord-299882-ee5wathm	28	3	r	r	NNP
cord-299882-ee5wathm	28	4	,	,	,
cord-299882-ee5wathm	28	5	0.70	0.70	CD
cord-299882-ee5wathm	28	6	[	[	-LRB-
cord-299882-ee5wathm	28	7	P	p	NN
cord-299882-ee5wathm	28	8	<	<	XX
cord-299882-ee5wathm	28	9	.001	.001	CD
cord-299882-ee5wathm	28	10	]	]	-RRB-
cord-299882-ee5wathm	28	11	and	and	CC
cord-299882-ee5wathm	28	12	0.71	0.71	CD
cord-299882-ee5wathm	28	13	[	[	-LRB-
cord-299882-ee5wathm	28	14	P	p	NN
cord-299882-ee5wathm	28	15	<	<	XX
cord-299882-ee5wathm	28	16	.001	.001	CD
cord-299882-ee5wathm	28	17	]	]	-RRB-
cord-299882-ee5wathm	28	18	,	,	,
cord-299882-ee5wathm	28	19	respectively	respectively	RB
cord-299882-ee5wathm	28	20	)	)	-RRB-
cord-299882-ee5wathm	28	21	across	across	IN
cord-299882-ee5wathm	28	22	countries	country	NNS
cord-299882-ee5wathm	28	23	.	.	.
cord-299882-ee5wathm	29	1	However	however	RB
cord-299882-ee5wathm	29	2	,	,	,
cord-299882-ee5wathm	29	3	the	the	DT
cord-299882-ee5wathm	29	4	percent	percent	NN
cord-299882-ee5wathm	29	5	of	of	IN
cord-299882-ee5wathm	29	6	explained	explained	JJ
cord-299882-ee5wathm	29	7	variance	variance	NN
cord-299882-ee5wathm	29	8	for	for	IN
cord-299882-ee5wathm	29	9	either	either	DT
cord-299882-ee5wathm	29	10	correlation	correlation	NN
cord-299882-ee5wathm	29	11	was	be	VBD
cord-299882-ee5wathm	29	12	poor	poor	JJ
cord-299882-ee5wathm	29	13	,	,	,
cord-299882-ee5wathm	29	14	with	with	IN
cord-299882-ee5wathm	29	15	infections	infection	NNS
cord-299882-ee5wathm	29	16	and	and	CC
cord-299882-ee5wathm	29	17	deaths	death	NNS
cord-299882-ee5wathm	29	18	explaining	explain	VBG
cord-299882-ee5wathm	29	19	only	only	RB
cord-299882-ee5wathm	29	20	29.5	29.5	CD
cord-299882-ee5wathm	29	21	%	%	NN
cord-299882-ee5wathm	29	22	and	and	CC
cord-299882-ee5wathm	29	23	26.9	26.9	CD
cord-299882-ee5wathm	29	24	%	%	NN
cord-299882-ee5wathm	29	25	,	,	,
cord-299882-ee5wathm	29	26	respectively	respectively	RB
cord-299882-ee5wathm	29	27	,	,	,
cord-299882-ee5wathm	29	28	of	of	IN
cord-299882-ee5wathm	29	29	the	the	DT
cord-299882-ee5wathm	29	30	variance	variance	NN
cord-299882-ee5wathm	29	31	in	in	IN
cord-299882-ee5wathm	29	32	trials	trial	NNS
cord-299882-ee5wathm	29	33	between	between	IN
cord-299882-ee5wathm	29	34	countries	country	NNS
cord-299882-ee5wathm	29	35	.	.	.
cord-299882-ee5wathm	30	1	This	this	DT
cord-299882-ee5wathm	30	2	indicates	indicate	VBZ
cord-299882-ee5wathm	30	3	that	that	IN
cord-299882-ee5wathm	30	4	in	in	IN
cord-299882-ee5wathm	30	5	many	many	JJ
cord-299882-ee5wathm	30	6	areas	area	NNS
cord-299882-ee5wathm	30	7	effected	effect	VBN
cord-299882-ee5wathm	30	8	by	by	IN
cord-299882-ee5wathm	30	9	COVID-19	COVID-19	NNP
cord-299882-ee5wathm	30	10	,	,	,
cord-299882-ee5wathm	30	11	clinical	clinical	JJ
cord-299882-ee5wathm	30	12	trials	trial	NNS
cord-299882-ee5wathm	30	13	are	be	VBP
cord-299882-ee5wathm	30	14	generally	generally	RB
cord-299882-ee5wathm	30	15	not	not	RB
cord-299882-ee5wathm	30	16	accessible	accessible	JJ
cord-299882-ee5wathm	30	17	or	or	CC
cord-299882-ee5wathm	30	18	disproportionately	disproportionately	RB
cord-299882-ee5wathm	30	19	fewer	few	JJR
cord-299882-ee5wathm	30	20	than	than	IN
cord-299882-ee5wathm	30	21	would	would	MD
cord-299882-ee5wathm	30	22	be	be	VB
cord-299882-ee5wathm	30	23	expected	expect	VBN
cord-299882-ee5wathm	30	24	based	base	VBN
cord-299882-ee5wathm	30	25	on	on	IN
cord-299882-ee5wathm	30	26	disease	disease	NN
cord-299882-ee5wathm	30	27	burden	burden	NN
cord-299882-ee5wathm	30	28	.	.	.
cord-299882-ee5wathm	31	1	Trials	trial	NNS
cord-299882-ee5wathm	31	2	examined	examine	VBD
cord-299882-ee5wathm	31	3	309	309	CD
cord-299882-ee5wathm	31	4	unique	unique	JJ
cord-299882-ee5wathm	31	5	COVID-19	covid-19	JJ
cord-299882-ee5wathm	31	6	interventions	intervention	NNS
cord-299882-ee5wathm	31	7	,	,	,
cord-299882-ee5wathm	31	8	with	with	IN
cord-299882-ee5wathm	31	9	the	the	DT
cord-299882-ee5wathm	31	10	10	10	CD
cord-299882-ee5wathm	31	11	most	most	RBS
cord-299882-ee5wathm	31	12	prevalent	prevalent	JJ
cord-299882-ee5wathm	31	13	interventions	intervention	NNS
cord-299882-ee5wathm	31	14	being	be	VBG
cord-299882-ee5wathm	31	15	tested	test	VBN
cord-299882-ee5wathm	31	16	in	in	IN
cord-299882-ee5wathm	31	17	65	65	CD
cord-299882-ee5wathm	31	18	%	%	NN
cord-299882-ee5wathm	31	19	of	of	IN
cord-299882-ee5wathm	31	20	studies	study	NNS
cord-299882-ee5wathm	31	21	(	(	-LRB-
cord-299882-ee5wathm	31	22	Supplementary	Supplementary	NNP
cord-299882-ee5wathm	31	23	Figure	Figure	NNP
cord-299882-ee5wathm	31	24	1C	1c	NN
cord-299882-ee5wathm	31	25	)	)	-RRB-
cord-299882-ee5wathm	31	26	.	.	.
cord-299882-ee5wathm	32	1	Controversial	controversial	JJ
cord-299882-ee5wathm	32	2	or	or	CC
cord-299882-ee5wathm	32	3	undefined	undefined	JJ
cord-299882-ee5wathm	32	4	interventions	intervention	NNS
cord-299882-ee5wathm	32	5	including	include	VBG
cord-299882-ee5wathm	32	6	hydroxychloroquine	hydroxychloroquine	NN
cord-299882-ee5wathm	32	7	,	,	,
cord-299882-ee5wathm	32	8	Traditional	traditional	JJ
cord-299882-ee5wathm	32	9	medicine	medicine	NN
cord-299882-ee5wathm	32	10	,	,	,
cord-299882-ee5wathm	32	11	plasma	plasma	NN
cord-299882-ee5wathm	32	12	products	product	NNS
cord-299882-ee5wathm	32	13	,	,	,
cord-299882-ee5wathm	32	14	and	and	CC
cord-299882-ee5wathm	32	15	stem	stem	VB
cord-299882-ee5wathm	32	16	cell	cell	NN
cord-299882-ee5wathm	32	17	products	product	NNS
cord-299882-ee5wathm	32	18	were	be	VBD
cord-299882-ee5wathm	32	19	tested	test	VBN
cord-299882-ee5wathm	32	20	in	in	IN
cord-299882-ee5wathm	32	21	a	a	DT
cord-299882-ee5wathm	32	22	substantial	substantial	JJ
cord-299882-ee5wathm	32	23	number	number	NN
cord-299882-ee5wathm	32	24	of	of	IN
cord-299882-ee5wathm	32	25	trials	trial	NNS
cord-299882-ee5wathm	32	26	(	(	-LRB-
cord-299882-ee5wathm	32	27	217	217	CD
cord-299882-ee5wathm	32	28	,	,	,
cord-299882-ee5wathm	32	29	130	130	CD
cord-299882-ee5wathm	32	30	,	,	,
cord-299882-ee5wathm	32	31	58	58	CD
cord-299882-ee5wathm	32	32	,	,	,
cord-299882-ee5wathm	32	33	and	and	CC
cord-299882-ee5wathm	32	34	53	53	CD
cord-299882-ee5wathm	32	35	trials	trial	NNS
cord-299882-ee5wathm	32	36	,	,	,
cord-299882-ee5wathm	32	37	respectively	respectively	RB
cord-299882-ee5wathm	32	38	)	)	-RRB-
cord-299882-ee5wathm	32	39	.	.	.
cord-299882-ee5wathm	33	1	4	4	LS
cord-299882-ee5wathm	33	2	,	,	,
cord-299882-ee5wathm	33	3	6	6	CD
cord-299882-ee5wathm	34	1	We	-PRON-	PRP
cord-299882-ee5wathm	34	2	assessed	assess	VBD
cord-299882-ee5wathm	34	3	the	the	DT
cord-299882-ee5wathm	34	4	strength	strength	NN
cord-299882-ee5wathm	34	5	of	of	IN
cord-299882-ee5wathm	34	6	preclinical	preclinical	JJ
cord-299882-ee5wathm	34	7	evidence	evidence	NN
cord-299882-ee5wathm	34	8	supporting	support	VBG
cord-299882-ee5wathm	34	9	the	the	DT
cord-299882-ee5wathm	34	10	most	most	RBS
cord-299882-ee5wathm	34	11	popular	popular	JJ
cord-299882-ee5wathm	34	12	interventional	interventional	JJ
cord-299882-ee5wathm	34	13	drugs	drug	NNS
cord-299882-ee5wathm	34	14	purported	purport	VBN
cord-299882-ee5wathm	34	15	to	to	TO
cord-299882-ee5wathm	34	16	have	have	VB
cord-299882-ee5wathm	34	17	direct	direct	JJ
cord-299882-ee5wathm	34	18	anti	anti	JJ
cord-299882-ee5wathm	34	19	-	-	JJ
cord-299882-ee5wathm	34	20	viral	viral	JJ
cord-299882-ee5wathm	34	21	activity	activity	NN
cord-299882-ee5wathm	34	22	by	by	IN
cord-299882-ee5wathm	34	23	examining	examine	VBG
cord-299882-ee5wathm	34	24	all	all	DT
cord-299882-ee5wathm	34	25	related	relate	VBN
cord-299882-ee5wathm	34	26	PubMed	PubMed	NNP
cord-299882-ee5wathm	34	27	entries	entry	NNS
cord-299882-ee5wathm	34	28	(	(	-LRB-
cord-299882-ee5wathm	34	29	Supplementary	Supplementary	NNP
cord-299882-ee5wathm	34	30	Figure	Figure	NNP
cord-299882-ee5wathm	34	31	1D	1d	CD
cord-299882-ee5wathm	34	32	)	)	-RRB-
cord-299882-ee5wathm	34	33	.	.	.
cord-299882-ee5wathm	35	1	PubMed	PubMed	NNP
cord-299882-ee5wathm	35	2	queries	query	NNS
cord-299882-ee5wathm	35	3	were	be	VBD
cord-299882-ee5wathm	35	4	conducted	conduct	VBN
cord-299882-ee5wathm	35	5	by	by	IN
cord-299882-ee5wathm	35	6	manually	manually	RB
cord-299882-ee5wathm	35	7	searching	search	VBG
cord-299882-ee5wathm	35	8	for	for	IN
cord-299882-ee5wathm	35	9	the	the	DT
cord-299882-ee5wathm	35	10	intervention	intervention	NN
cord-299882-ee5wathm	35	11	name	name	NN
cord-299882-ee5wathm	35	12	and	and	CC
cord-299882-ee5wathm	36	1	COVID-19	COVID-19	NNP
cord-299882-ee5wathm	36	2	OR	OR	NNP
cord-299882-ee5wathm	36	3	SARS	SARS	NNP
cord-299882-ee5wathm	36	4	-	-	HYPH
cord-299882-ee5wathm	36	5	CoV-2	CoV-2	NNP
cord-299882-ee5wathm	36	6	and	and	CC
cord-299882-ee5wathm	36	7	reviewing	review	VBG
cord-299882-ee5wathm	36	8	each	each	DT
cord-299882-ee5wathm	36	9	entry	entry	NN
cord-299882-ee5wathm	36	10	.	.	.
cord-299882-ee5wathm	37	1	Hydroxychloroquine	Hydroxychloroquine	NNP
cord-299882-ee5wathm	37	2	,	,	,
cord-299882-ee5wathm	37	3	Traditional	traditional	JJ
cord-299882-ee5wathm	37	4	medicine	medicine	NN
cord-299882-ee5wathm	37	5	,	,	,
cord-299882-ee5wathm	37	6	and	and	CC
cord-299882-ee5wathm	37	7	remdesivir	remdesivir	NNP
cord-299882-ee5wathm	37	8	had	have	VBD
cord-299882-ee5wathm	37	9	more	more	JJR
cord-299882-ee5wathm	37	10	than	than	IN
cord-299882-ee5wathm	37	11	one	one	CD
cord-299882-ee5wathm	37	12	publication	publication	NN
cord-299882-ee5wathm	37	13	describing	describe	VBG
cord-299882-ee5wathm	37	14	experiments	experiment	NNS
cord-299882-ee5wathm	37	15	that	that	WDT
cord-299882-ee5wathm	37	16	directly	directly	RB
cord-299882-ee5wathm	37	17	assessed	assess	VBN
cord-299882-ee5wathm	37	18	In	in	IN
cord-299882-ee5wathm	37	19	vitro	vitro	FW
cord-299882-ee5wathm	37	20	or	or	CC
cord-299882-ee5wathm	37	21	in	in	IN
cord-299882-ee5wathm	37	22	vivo	vivo	FW
cord-299882-ee5wathm	37	23	anti	anti	JJ
cord-299882-ee5wathm	37	24	-	-	JJ
cord-299882-ee5wathm	37	25	viral	viral	JJ
cord-299882-ee5wathm	37	26	activity	activity	NN
cord-299882-ee5wathm	37	27	.	.	.
cord-299882-ee5wathm	38	1	Preclinical	preclinical	JJ
cord-299882-ee5wathm	38	2	evidence	evidence	NN
cord-299882-ee5wathm	38	3	for	for	IN
cord-299882-ee5wathm	38	4	lopinavir	lopinavir	NNS
cord-299882-ee5wathm	38	5	/	/	SYM
cord-299882-ee5wathm	38	6	ritonavir	ritonavir	NNS
cord-299882-ee5wathm	38	7	,	,	,
cord-299882-ee5wathm	38	8	azithromycin	azithromycin	NNP
cord-299882-ee5wathm	38	9	,	,	,
cord-299882-ee5wathm	38	10	and	and	CC
cord-299882-ee5wathm	38	11	arbidol	arbidol	NN
cord-299882-ee5wathm	38	12	were	be	VBD
cord-299882-ee5wathm	38	13	limited	limit	VBN
cord-299882-ee5wathm	38	14	to	to	IN
cord-299882-ee5wathm	38	15	single	single	JJ
cord-299882-ee5wathm	38	16	publications	publication	NNS
cord-299882-ee5wathm	38	17	.	.	.
cord-299882-ee5wathm	39	1	These	these	DT
cord-299882-ee5wathm	39	2	findings	finding	NNS
cord-299882-ee5wathm	39	3	indicate	indicate	VBP
cord-299882-ee5wathm	39	4	that	that	IN
cord-299882-ee5wathm	39	5	COVID-19	covid-19	VB
cord-299882-ee5wathm	39	6	interventional	interventional	JJ
cord-299882-ee5wathm	39	7	trials	trial	NNS
cord-299882-ee5wathm	39	8	have	have	VBP
cord-299882-ee5wathm	39	9	heterogenous	heterogenous	JJ
cord-299882-ee5wathm	39	10	designs	design	NNS
cord-299882-ee5wathm	39	11	,	,	,
cord-299882-ee5wathm	39	12	but	but	CC
cord-299882-ee5wathm	39	13	are	be	VBP
cord-299882-ee5wathm	39	14	predominantly	predominantly	RB
cord-299882-ee5wathm	39	15	open	open	JJ
cord-299882-ee5wathm	39	16	-	-	HYPH
cord-299882-ee5wathm	39	17	label	label	NN
cord-299882-ee5wathm	39	18	,	,	,
cord-299882-ee5wathm	39	19	single	single	JJ
cord-299882-ee5wathm	39	20	-	-	HYPH
cord-299882-ee5wathm	39	21	center	center	NN
cord-299882-ee5wathm	39	22	studies	study	NNS
cord-299882-ee5wathm	39	23	regardless	regardless	RB
cord-299882-ee5wathm	39	24	of	of	IN
cord-299882-ee5wathm	39	25	geography	geography	NN
cord-299882-ee5wathm	39	26	.	.	.
cord-299882-ee5wathm	40	1	Thus	thus	RB
cord-299882-ee5wathm	40	2	,	,	,
cord-299882-ee5wathm	40	3	most	most	JJS
cord-299882-ee5wathm	40	4	studies	study	NNS
cord-299882-ee5wathm	40	5	are	be	VBP
cord-299882-ee5wathm	40	6	unlikely	unlikely	JJ
cord-299882-ee5wathm	40	7	to	to	TO
cord-299882-ee5wathm	40	8	be	be	VB
cord-299882-ee5wathm	40	9	generalizable	generalizable	JJ
cord-299882-ee5wathm	40	10	,	,	,
cord-299882-ee5wathm	40	11	susceptible	susceptible	JJ
cord-299882-ee5wathm	40	12	to	to	IN
cord-299882-ee5wathm	40	13	reporting	report	VBG
cord-299882-ee5wathm	40	14	bias	bias	NN
cord-299882-ee5wathm	40	15	,	,	,
cord-299882-ee5wathm	40	16	and	and	CC
cord-299882-ee5wathm	40	17	may	may	MD
cord-299882-ee5wathm	40	18	not	not	RB
cord-299882-ee5wathm	40	19	be	be	VB
cord-299882-ee5wathm	40	20	feasible	feasible	JJ
cord-299882-ee5wathm	40	21	due	due	IN
cord-299882-ee5wathm	40	22	to	to	IN
cord-299882-ee5wathm	40	23	the	the	DT
cord-299882-ee5wathm	40	24	large	large	JJ
cord-299882-ee5wathm	40	25	planned	planned	JJ
cord-299882-ee5wathm	40	26	enrollment	enrollment	NN
cord-299882-ee5wathm	40	27	sizes	size	NNS
cord-299882-ee5wathm	40	28	.	.	.
cord-299882-ee5wathm	41	1	The	the	DT
cord-299882-ee5wathm	41	2	infrequent	infrequent	JJ
cord-299882-ee5wathm	41	3	use	use	NN
cord-299882-ee5wathm	41	4	of	of	IN
cord-299882-ee5wathm	41	5	placebo	placebo	NN
cord-299882-ee5wathm	41	6	for	for	IN
cord-299882-ee5wathm	41	7	comparisons	comparison	NNS
cord-299882-ee5wathm	41	8	or	or	CC
cord-299882-ee5wathm	41	9	exclusion	exclusion	NN
cord-299882-ee5wathm	41	10	of	of	IN
cord-299882-ee5wathm	41	11	other	other	JJ
cord-299882-ee5wathm	41	12	commonly	commonly	RB
cord-299882-ee5wathm	41	13	used	use	VBN
cord-299882-ee5wathm	41	14	COVID-19	COVID-19	NNP
cord-299882-ee5wathm	41	15	interventions	intervention	NNS
cord-299882-ee5wathm	41	16	limits	limit	VBZ
cord-299882-ee5wathm	41	17	the	the	DT
cord-299882-ee5wathm	41	18	interpretation	interpretation	NN
cord-299882-ee5wathm	41	19	of	of	IN
cord-299882-ee5wathm	41	20	many	many	JJ
cord-299882-ee5wathm	41	21	trials	trial	NNS
cord-299882-ee5wathm	41	22	as	as	IN
cord-299882-ee5wathm	41	23	interactions	interaction	NNS
cord-299882-ee5wathm	41	24	between	between	IN
cord-299882-ee5wathm	41	25	drugs	drug	NNS
cord-299882-ee5wathm	41	26	in	in	IN
cord-299882-ee5wathm	41	27	both	both	DT
cord-299882-ee5wathm	41	28	safety	safety	NN
cord-299882-ee5wathm	41	29	and	and	CC
cord-299882-ee5wathm	41	30	efficacy	efficacy	NN
cord-299882-ee5wathm	41	31	can	can	MD
cord-299882-ee5wathm	41	32	not	not	RB
cord-299882-ee5wathm	41	33	be	be	VB
cord-299882-ee5wathm	41	34	discounted	discount	VBN
cord-299882-ee5wathm	41	35	,	,	,
cord-299882-ee5wathm	41	36	and	and	CC
cord-299882-ee5wathm	41	37	the	the	DT
cord-299882-ee5wathm	41	38	additive	additive	NN
cord-299882-ee5wathm	41	39	or	or	CC
cord-299882-ee5wathm	41	40	synergistic	synergistic	JJ
cord-299882-ee5wathm	41	41	effects	effect	NNS
cord-299882-ee5wathm	41	42	of	of	IN
cord-299882-ee5wathm	41	43	treatments	treatment	NNS
cord-299882-ee5wathm	41	44	can	can	MD
cord-299882-ee5wathm	41	45	not	not	RB
cord-299882-ee5wathm	41	46	be	be	VB
cord-299882-ee5wathm	41	47	distinguished	distinguish	VBN
cord-299882-ee5wathm	41	48	.	.	.
cord-299882-ee5wathm	42	1	We	-PRON-	PRP
cord-299882-ee5wathm	42	2	also	also	RB
cord-299882-ee5wathm	42	3	noted	note	VBD
cord-299882-ee5wathm	42	4	that	that	IN
cord-299882-ee5wathm	42	5	endpoints	endpoint	NNS
cord-299882-ee5wathm	42	6	varied	vary	VBN
cord-299882-ee5wathm	42	7	widely	widely	RB
cord-299882-ee5wathm	42	8	and	and	CC
cord-299882-ee5wathm	42	9	included	include	VBD
cord-299882-ee5wathm	42	10	diverse	diverse	JJ
cord-299882-ee5wathm	42	11	surrogates	surrogate	NNS
cord-299882-ee5wathm	42	12	,	,	,
cord-299882-ee5wathm	42	13	which	which	WDT
cord-299882-ee5wathm	42	14	will	will	MD
cord-299882-ee5wathm	42	15	confound	confound	VB
cord-299882-ee5wathm	42	16	the	the	DT
cord-299882-ee5wathm	42	17	interpretation	interpretation	NN
cord-299882-ee5wathm	42	18	and	and	CC
cord-299882-ee5wathm	42	19	comparison	comparison	NN
cord-299882-ee5wathm	42	20	of	of	IN
cord-299882-ee5wathm	42	21	trials	trial	NNS
cord-299882-ee5wathm	42	22	.	.	.
cord-299882-ee5wathm	43	1	Geographic	geographic	JJ
cord-299882-ee5wathm	43	2	differences	difference	NNS
cord-299882-ee5wathm	43	3	in	in	IN
cord-299882-ee5wathm	43	4	trial	trial	NN
cord-299882-ee5wathm	43	5	characteristics	characteristic	NNS
cord-299882-ee5wathm	43	6	,	,	,
cord-299882-ee5wathm	43	7	the	the	DT
cord-299882-ee5wathm	43	8	poor	poor	JJ
cord-299882-ee5wathm	43	9	alignment	alignment	NN
cord-299882-ee5wathm	43	10	between	between	IN
cord-299882-ee5wathm	43	11	trial	trial	NN
cord-299882-ee5wathm	43	12	numbers	number	NNS
cord-299882-ee5wathm	43	13	and	and	CC
cord-299882-ee5wathm	43	14	COVID-19	covid-19	JJ
cord-299882-ee5wathm	43	15	disease	disease	NN
cord-299882-ee5wathm	43	16	burden	burden	NN
cord-299882-ee5wathm	43	17	,	,	,
cord-299882-ee5wathm	43	18	and	and	CC
cord-299882-ee5wathm	43	19	lack	lack	NN
cord-299882-ee5wathm	43	20	of	of	IN
cord-299882-ee5wathm	43	21	international	international	JJ
cord-299882-ee5wathm	43	22	collaborations	collaboration	NNS
cord-299882-ee5wathm	43	23	suggest	suggest	VBP
cord-299882-ee5wathm	43	24	that	that	IN
cord-299882-ee5wathm	43	25	better	well	JJR
cord-299882-ee5wathm	43	26	integration	integration	NN
cord-299882-ee5wathm	43	27	of	of	IN
cord-299882-ee5wathm	43	28	clinical	clinical	JJ
cord-299882-ee5wathm	43	29	research	research	NN
cord-299882-ee5wathm	43	30	efforts	effort	NNS
cord-299882-ee5wathm	43	31	is	be	VBZ
cord-299882-ee5wathm	43	32	warranted	warrant	VBN
cord-299882-ee5wathm	43	33	to	to	TO
cord-299882-ee5wathm	43	34	combat	combat	VB
cord-299882-ee5wathm	43	35	a	a	DT
cord-299882-ee5wathm	43	36	global	global	JJ
cord-299882-ee5wathm	43	37	public	public	JJ
cord-299882-ee5wathm	43	38	health	health	NN
cord-299882-ee5wathm	43	39	crisis	crisis	NN
cord-299882-ee5wathm	43	40	.	.	.
cord-299882-ee5wathm	44	1	In	in	IN
cord-299882-ee5wathm	44	2	particular	particular	JJ
cord-299882-ee5wathm	44	3	,	,	,
cord-299882-ee5wathm	44	4	given	give	VBN
cord-299882-ee5wathm	44	5	the	the	DT
cord-299882-ee5wathm	44	6	widespread	widespread	JJ
cord-299882-ee5wathm	44	7	impact	impact	NN
cord-299882-ee5wathm	44	8	of	of	IN
cord-299882-ee5wathm	44	9	the	the	DT
cord-299882-ee5wathm	44	10	COVID-19	COVID-19	NNP
cord-299882-ee5wathm	44	11	across	across	IN
cord-299882-ee5wathm	44	12	nearly	nearly	RB
cord-299882-ee5wathm	44	13	all	all	DT
cord-299882-ee5wathm	44	14	continents	continent	NNS
cord-299882-ee5wathm	44	15	,	,	,
cord-299882-ee5wathm	44	16	it	-PRON-	PRP
cord-299882-ee5wathm	44	17	is	be	VBZ
cord-299882-ee5wathm	44	18	surprising	surprising	JJ
cord-299882-ee5wathm	44	19	that	that	IN
cord-299882-ee5wathm	44	20	there	there	EX
cord-299882-ee5wathm	44	21	is	be	VBZ
cord-299882-ee5wathm	44	22	very	very	RB
cord-299882-ee5wathm	44	23	little	little	JJ
cord-299882-ee5wathm	44	24	evidence	evidence	NN
cord-299882-ee5wathm	44	25	of	of	IN
cord-299882-ee5wathm	44	26	any	any	DT
cord-299882-ee5wathm	44	27	international	international	JJ
cord-299882-ee5wathm	44	28	collaboration	collaboration	NN
cord-299882-ee5wathm	44	29	.	.	.
cord-299882-ee5wathm	45	1	This	this	DT
cord-299882-ee5wathm	45	2	has	have	VBZ
cord-299882-ee5wathm	45	3	undoubted	undoubted	JJ
cord-299882-ee5wathm	45	4	contributed	contribute	VBN
cord-299882-ee5wathm	45	5	to	to	IN
cord-299882-ee5wathm	45	6	many	many	JJ
cord-299882-ee5wathm	45	7	studies	study	NNS
cord-299882-ee5wathm	45	8	examining	examine	VBG
cord-299882-ee5wathm	45	9	the	the	DT
cord-299882-ee5wathm	45	10	same	same	JJ
cord-299882-ee5wathm	45	11	interventions	intervention	NNS
cord-299882-ee5wathm	45	12	,	,	,
cord-299882-ee5wathm	45	13	which	which	WDT
cord-299882-ee5wathm	45	14	is	be	VBZ
cord-299882-ee5wathm	45	15	likely	likely	RB
cord-299882-ee5wathm	45	16	wasteful	wasteful	JJ
cord-299882-ee5wathm	45	17	particularly	particularly	RB
cord-299882-ee5wathm	45	18	because	because	IN
cord-299882-ee5wathm	45	19	the	the	DT
cord-299882-ee5wathm	45	20	design	design	NN
cord-299882-ee5wathm	45	21	and	and	CC
cord-299882-ee5wathm	45	22	endpoints	endpoint	NNS
cord-299882-ee5wathm	45	23	in	in	IN
cord-299882-ee5wathm	45	24	many	many	JJ
cord-299882-ee5wathm	45	25	trials	trial	NNS
cord-299882-ee5wathm	45	26	are	be	VBP
cord-299882-ee5wathm	45	27	generally	generally	RB
cord-299882-ee5wathm	45	28	unique	unique	JJ
cord-299882-ee5wathm	45	29	and	and	CC
cord-299882-ee5wathm	45	30	preclude	preclude	VB
cord-299882-ee5wathm	45	31	comparisons	comparison	NNS
cord-299882-ee5wathm	45	32	.	.	.
cord-299882-ee5wathm	46	1	Internal	internal	JJ
cord-299882-ee5wathm	46	2	collaboration	collaboration	NN
cord-299882-ee5wathm	46	3	should	should	MD
cord-299882-ee5wathm	46	4	be	be	VB
cord-299882-ee5wathm	46	5	encouraged	encourage	VBN
cord-299882-ee5wathm	46	6	as	as	IN
cord-299882-ee5wathm	46	7	it	-PRON-	PRP
cord-299882-ee5wathm	46	8	may	may	MD
cord-299882-ee5wathm	46	9	improve	improve	VB
cord-299882-ee5wathm	46	10	the	the	DT
cord-299882-ee5wathm	46	11	quality	quality	NN
cord-299882-ee5wathm	46	12	of	of	IN
cord-299882-ee5wathm	46	13	trials	trial	NNS
cord-299882-ee5wathm	46	14	by	by	IN
cord-299882-ee5wathm	46	15	involving	involve	VBG
cord-299882-ee5wathm	46	16	additional	additional	JJ
cord-299882-ee5wathm	46	17	investigators	investigator	NNS
cord-299882-ee5wathm	46	18	,	,	,
cord-299882-ee5wathm	46	19	and	and	CC
cord-299882-ee5wathm	46	20	global	global	JJ
cord-299882-ee5wathm	46	21	participation	participation	NN
cord-299882-ee5wathm	46	22	may	may	MD
cord-299882-ee5wathm	46	23	help	help	VB
cord-299882-ee5wathm	46	24	address	address	VB
cord-299882-ee5wathm	46	25	health	health	NN
cord-299882-ee5wathm	46	26	needs	need	NNS
cord-299882-ee5wathm	46	27	across	across	IN
cord-299882-ee5wathm	46	28	the	the	DT
cord-299882-ee5wathm	46	29	world	world	NN
cord-299882-ee5wathm	46	30	and	and	CC
cord-299882-ee5wathm	46	31	improve	improve	VB
cord-299882-ee5wathm	46	32	the	the	DT
cord-299882-ee5wathm	46	33	generalizability	generalizability	NN
cord-299882-ee5wathm	46	34	of	of	IN
cord-299882-ee5wathm	46	35	results	result	NNS
cord-299882-ee5wathm	46	36	.	.	.
cord-299882-ee5wathm	47	1	This	this	DT
cord-299882-ee5wathm	47	2	analysis	analysis	NN
cord-299882-ee5wathm	47	3	also	also	RB
cord-299882-ee5wathm	47	4	highlights	highlight	VBZ
cord-299882-ee5wathm	47	5	neglected	neglect	VBN
cord-299882-ee5wathm	47	6	aspects	aspect	NNS
cord-299882-ee5wathm	47	7	of	of	IN
cord-299882-ee5wathm	47	8	COVID-19	covid-19	JJ
cord-299882-ee5wathm	47	9	research	research	NN
cord-299882-ee5wathm	47	10	.	.	.
cord-299882-ee5wathm	48	1	For	for	IN
cord-299882-ee5wathm	48	2	instance	instance	NN
cord-299882-ee5wathm	48	3	,	,	,
cord-299882-ee5wathm	48	4	multiplicity	multiplicity	NN
cord-299882-ee5wathm	48	5	of	of	IN
cord-299882-ee5wathm	48	6	interventions	intervention	NNS
cord-299882-ee5wathm	48	7	being	be	VBG
cord-299882-ee5wathm	48	8	tested	test	VBN
cord-299882-ee5wathm	48	9	was	be	VBD
cord-299882-ee5wathm	48	10	prevalent	prevalent	JJ
cord-299882-ee5wathm	48	11	,	,	,
cord-299882-ee5wathm	48	12	as	as	RB
cord-299882-ee5wathm	48	13	well	well	RB
cord-299882-ee5wathm	48	14	as	as	IN
cord-299882-ee5wathm	48	15	a	a	DT
cord-299882-ee5wathm	48	16	lack	lack	NN
cord-299882-ee5wathm	48	17	of	of	IN
cord-299882-ee5wathm	48	18	attention	attention	NN
cord-299882-ee5wathm	48	19	to	to	IN
cord-299882-ee5wathm	48	20	the	the	DT
cord-299882-ee5wathm	48	21	efficacy	efficacy	NN
cord-299882-ee5wathm	48	22	of	of	IN
cord-299882-ee5wathm	48	23	nonpharmaceutical	nonpharmaceutical	JJ
cord-299882-ee5wathm	48	24	and	and	CC
cord-299882-ee5wathm	48	25	prevention	prevention	NN
cord-299882-ee5wathm	48	26	interventions	intervention	NNS
cord-299882-ee5wathm	48	27	.	.	.
cord-299882-ee5wathm	49	1	The	the	DT
cord-299882-ee5wathm	49	2	scientific	scientific	JJ
cord-299882-ee5wathm	49	3	rationale	rationale	NN
cord-299882-ee5wathm	49	4	of	of	IN
cord-299882-ee5wathm	49	5	many	many	JJ
cord-299882-ee5wathm	49	6	trials	trial	NNS
cord-299882-ee5wathm	49	7	appears	appear	VBZ
cord-299882-ee5wathm	49	8	poor	poor	JJ
cord-299882-ee5wathm	49	9	,	,	,
cord-299882-ee5wathm	49	10	as	as	IN
cord-299882-ee5wathm	49	11	even	even	RB
cord-299882-ee5wathm	49	12	the	the	DT
cord-299882-ee5wathm	49	13	most	most	RBS
cord-299882-ee5wathm	49	14	prevalent	prevalent	JJ
cord-299882-ee5wathm	49	15	interventions	intervention	NNS
cord-299882-ee5wathm	49	16	purported	purport	VBN
cord-299882-ee5wathm	49	17	to	to	TO
cord-299882-ee5wathm	49	18	have	have	VB
cord-299882-ee5wathm	49	19	anti	anti	JJ
cord-299882-ee5wathm	49	20	-	-	JJ
cord-299882-ee5wathm	49	21	viral	viral	JJ
cord-299882-ee5wathm	49	22	activity	activity	NN
cord-299882-ee5wathm	49	23	were	be	VBD
cord-299882-ee5wathm	49	24	infrequently	infrequently	RB
cord-299882-ee5wathm	49	25	associated	associate	VBN
cord-299882-ee5wathm	49	26	with	with	IN
cord-299882-ee5wathm	49	27	preclinical	preclinical	JJ
cord-299882-ee5wathm	49	28	evidence	evidence	NN
cord-299882-ee5wathm	49	29	substantiated	substantiate	VBN
cord-299882-ee5wathm	49	30	by	by	IN
cord-299882-ee5wathm	49	31	independent	independent	JJ
cord-299882-ee5wathm	49	32	groups	group	NNS
cord-299882-ee5wathm	49	33	.	.	.
cord-299882-ee5wathm	50	1	Our	-PRON-	PRP$
cord-299882-ee5wathm	50	2	results	result	NNS
cord-299882-ee5wathm	50	3	call	call	VBP
cord-299882-ee5wathm	50	4	for	for	IN
cord-299882-ee5wathm	50	5	a	a	DT
cord-299882-ee5wathm	50	6	more	more	RBR
cord-299882-ee5wathm	50	7	careful	careful	JJ
cord-299882-ee5wathm	50	8	assessment	assessment	NN
cord-299882-ee5wathm	50	9	of	of	IN
cord-299882-ee5wathm	50	10	hypotheses	hypothesis	NNS
cord-299882-ee5wathm	50	11	prior	prior	RB
cord-299882-ee5wathm	50	12	to	to	IN
cord-299882-ee5wathm	50	13	clinical	clinical	JJ
cord-299882-ee5wathm	50	14	testing	testing	NN
cord-299882-ee5wathm	50	15	and	and	CC
cord-299882-ee5wathm	50	16	a	a	DT
cord-299882-ee5wathm	50	17	shift	shift	NN
cord-299882-ee5wathm	50	18	of	of	IN
cord-299882-ee5wathm	50	19	research	research	NN
cord-299882-ee5wathm	50	20	efforts	effort	NNS
cord-299882-ee5wathm	50	21	from	from	IN
cord-299882-ee5wathm	50	22	theory	theory	NN
cord-299882-ee5wathm	50	23	to	to	IN
cord-299882-ee5wathm	50	24	scientific	scientific	JJ
cord-299882-ee5wathm	50	25	experimentation	experimentation	NN
cord-299882-ee5wathm	50	26	.	.	.
cord-299882-ee5wathm	51	1	While	while	IN
cord-299882-ee5wathm	51	2	there	there	EX
cord-299882-ee5wathm	51	3	is	be	VBZ
cord-299882-ee5wathm	51	4	a	a	DT
cord-299882-ee5wathm	51	5	clear	clear	JJ
cord-299882-ee5wathm	51	6	need	need	NN
cord-299882-ee5wathm	51	7	for	for	IN
cord-299882-ee5wathm	51	8	speediness	speediness	NN
cord-299882-ee5wathm	51	9	,	,	,
cord-299882-ee5wathm	51	10	safe	safe	JJ
cord-299882-ee5wathm	51	11	and	and	CC
cord-299882-ee5wathm	51	12	effective	effective	JJ
cord-299882-ee5wathm	51	13	therapies	therapy	NNS
cord-299882-ee5wathm	51	14	can	can	MD
cord-299882-ee5wathm	51	15	only	only	RB
cord-299882-ee5wathm	51	16	be	be	VB
cord-299882-ee5wathm	51	17	discerned	discern	VBN
cord-299882-ee5wathm	51	18	from	from	IN
cord-299882-ee5wathm	51	19	rigorously	rigorously	RB
cord-299882-ee5wathm	51	20	designed	design	VBN
cord-299882-ee5wathm	51	21	and	and	CC
cord-299882-ee5wathm	51	22	conducted	conduct	VBN
cord-299882-ee5wathm	51	23	clinical	clinical	JJ
cord-299882-ee5wathm	51	24	trials	trial	NNS
cord-299882-ee5wathm	51	25	.	.	.
cord-299882-ee5wathm	52	1	We	-PRON-	PRP
cord-299882-ee5wathm	52	2	believe	believe	VBP
cord-299882-ee5wathm	52	3	that	that	IN
cord-299882-ee5wathm	52	4	an	an	DT
cord-299882-ee5wathm	52	5	assessment	assessment	NN
cord-299882-ee5wathm	52	6	of	of	IN
cord-299882-ee5wathm	52	7	the	the	DT
cord-299882-ee5wathm	52	8	quality	quality	NN
cord-299882-ee5wathm	52	9	and	and	CC
cord-299882-ee5wathm	52	10	rationale	rationale	NN
cord-299882-ee5wathm	52	11	for	for	IN
cord-299882-ee5wathm	52	12	COVID-	covid-	NN
cord-299882-ee5wathm	52	13	Randomized	Randomized	NNP
cord-299882-ee5wathm	52	14	Clinical	Clinical	NNP
cord-299882-ee5wathm	52	15	Trials	Trials	NNPS
cord-299882-ee5wathm	52	16	and	and	CC
cord-299882-ee5wathm	52	17	COVID-19	covid-19	NN
cord-299882-ee5wathm	52	18	:	:	:
cord-299882-ee5wathm	52	19	Managing	manage	VBG
cord-299882-ee5wathm	52	20	Expectations	expectation	NNS
cord-299882-ee5wathm	53	1	The	the	DT
cord-299882-ee5wathm	53	2	Urgency	Urgency	NNP
cord-299882-ee5wathm	53	3	of	of	IN
cord-299882-ee5wathm	53	4	Care	Care	NNP
cord-299882-ee5wathm	53	5	during	during	IN
cord-299882-ee5wathm	53	6	the	the	DT
cord-299882-ee5wathm	53	7	Covid-19	Covid-19	NNP
cord-299882-ee5wathm	53	8	Pandemic	Pandemic	NNP
cord-299882-ee5wathm	53	9	-Learning	-Learning	.
cord-299882-ee5wathm	54	1	as	as	IN
cord-299882-ee5wathm	54	2	We	-PRON-	PRP
cord-299882-ee5wathm	54	3	Go	go	VBP
cord-299882-ee5wathm	54	4	Waste	Waste	NNP
cord-299882-ee5wathm	54	5	in	in	IN
cord-299882-ee5wathm	54	6	covid-19	covid-19	NN
cord-299882-ee5wathm	54	7	research	research	NN
cord-299882-ee5wathm	55	1	COVID-19	covid-19	JJ
cord-299882-ee5wathm	55	2	coronavirus	coronavirus	NN
cord-299882-ee5wathm	55	3	research	research	NN
cord-299882-ee5wathm	55	4	has	have	VBZ
cord-299882-ee5wathm	55	5	overall	overall	RB
cord-299882-ee5wathm	55	6	low	low	JJ
cord-299882-ee5wathm	55	7	methodological	methodological	JJ
cord-299882-ee5wathm	55	8	quality	quality	NN
cord-299882-ee5wathm	55	9	thus	thus	RB
cord-299882-ee5wathm	55	10	far	far	RB
cord-299882-ee5wathm	55	11	:	:	:
cord-299882-ee5wathm	55	12	case	case	NN
cord-299882-ee5wathm	55	13	in	in	IN
cord-299882-ee5wathm	55	14	point	point	NN
cord-299882-ee5wathm	55	15	for	for	IN
cord-299882-ee5wathm	55	16	chloroquine	chloroquine	NN
cord-299882-ee5wathm	55	17	/	/	SYM
cord-299882-ee5wathm	55	18	hydroxychloroquine	hydroxychloroquine	NNP
cord-299882-ee5wathm	56	1	What	what	WP
cord-299882-ee5wathm	56	2	is	be	VBZ
cord-299882-ee5wathm	56	3	the	the	DT
cord-299882-ee5wathm	56	4	best	good	JJS
cord-299882-ee5wathm	56	5	drug	drug	NN
cord-299882-ee5wathm	56	6	to	to	TO
cord-299882-ee5wathm	56	7	treat	treat	VB
cord-299882-ee5wathm	56	8	COVID-19	COVID-19	NNP
cord-299882-ee5wathm	56	9	?	?	.
cord-299882-ee5wathm	57	1	The	the	DT
cord-299882-ee5wathm	57	2	need	need	NN
cord-299882-ee5wathm	57	3	for	for	IN
cord-299882-ee5wathm	57	4	randomized	randomized	JJ
cord-299882-ee5wathm	57	5	controlled	control	VBN
cord-299882-ee5wathm	57	6	trials	trial	NNS
cord-299882-ee5wathm	57	7	Preying	prey	VBG
cord-299882-ee5wathm	57	8	on	on	IN
cord-299882-ee5wathm	57	9	Public	Public	NNP
cord-299882-ee5wathm	57	10	Fears	Fears	NNPS
cord-299882-ee5wathm	57	11	and	and	CC
cord-299882-ee5wathm	57	12	Anxieties	Anxieties	NNPS
cord-299882-ee5wathm	57	13	in	in	IN
cord-299882-ee5wathm	57	14	a	a	DT
cord-299882-ee5wathm	57	15	Pandemic	pandemic	NN
cord-299882-ee5wathm	57	16	:	:	:
cord-299882-ee5wathm	57	17	Businesses	business	NNS
cord-299882-ee5wathm	57	18	Selling	sell	VBG
cord-299882-ee5wathm	57	19	Unproven	Unproven	NNP
cord-299882-ee5wathm	57	20	and	and	CC
cord-299882-ee5wathm	57	21	Unlicensed	unlicensed	JJ
cord-299882-ee5wathm	57	22	"	"	``
cord-299882-ee5wathm	57	23	Stem	Stem	NNP
cord-299882-ee5wathm	57	24	Cell	cell	NN
cord-299882-ee5wathm	57	25	Treatments	treatment	NNS
cord-299882-ee5wathm	57	26	"	"	''
cord-299882-ee5wathm	57	27	for	for	IN
cord-299882-ee5wathm	57	28	COVID-19	COVID-19	NNP
cord-299882-ee5wathm	57	29	Supplemental	Supplemental	NNP
cord-299882-ee5wathm	57	30	Table	Table	NNP
cord-299882-ee5wathm	57	31	1	1	CD
cord-299882-ee5wathm	57	32	.	.	.
cord-299882-ee5wathm	58	1	Characteristics	characteristic	NNS
cord-299882-ee5wathm	58	2	of	of	IN
cord-299882-ee5wathm	58	3	COVID-19	covid-19	JJ
cord-299882-ee5wathm	58	4	interventional	interventional	JJ
cord-299882-ee5wathm	58	5	trials	trial	NNS
cord-299882-ee5wathm	58	6	Scatter	scatter	VB
cord-299882-ee5wathm	58	7	plot	plot	NN
cord-299882-ee5wathm	58	8	of	of	IN
cord-299882-ee5wathm	58	9	COVID-19	covid-19	JJ
cord-299882-ee5wathm	58	10	trials	trial	NNS
cord-299882-ee5wathm	58	11	and	and	CC
cord-299882-ee5wathm	58	12	infections	infection	NNS
cord-299882-ee5wathm	58	13	(	(	-LRB-
cord-299882-ee5wathm	58	14	data	datum	NNS
cord-299882-ee5wathm	58	15	obtained	obtain	VBN
cord-299882-ee5wathm	58	16	from	from	IN
cord-299882-ee5wathm	58	17	the	the	DT
cord-299882-ee5wathm	58	18	Johns	Johns	NNP
cord-299882-ee5wathm	58	19	Hopkins	Hopkins	NNP
cord-299882-ee5wathm	58	20	COVID-19	COVID-19	NNP
cord-299882-ee5wathm	58	21	dashboard	dashboard	NN
cord-299882-ee5wathm	58	22	on	on	IN
cord-299882-ee5wathm	58	23	5/10/2020	5/10/2020	CD
cord-299882-ee5wathm	58	24	)	)	-RRB-
cord-299882-ee5wathm	58	25	across	across	IN
cord-299882-ee5wathm	58	26	60	60	CD
cord-299882-ee5wathm	58	27	countries	country	NNS
cord-299882-ee5wathm	58	28	with	with	IN
cord-299882-ee5wathm	58	29	available	available	JJ
cord-299882-ee5wathm	58	30	data	datum	NNS
cord-299882-ee5wathm	58	31	Scatter	scatter	NN
cord-299882-ee5wathm	58	32	plot	plot	NN
cord-299882-ee5wathm	58	33	of	of	IN
cord-299882-ee5wathm	58	34	COVID-19	covid-19	JJ
cord-299882-ee5wathm	58	35	trials	trial	NNS
cord-299882-ee5wathm	58	36	and	and	CC
cord-299882-ee5wathm	58	37	deaths	death	NNS
cord-299882-ee5wathm	58	38	across	across	IN
cord-299882-ee5wathm	58	39	58	58	CD
cord-299882-ee5wathm	58	40	countries	country	NNS
cord-299882-ee5wathm	58	41	with	with	IN
cord-299882-ee5wathm	58	42	available	available	JJ
cord-299882-ee5wathm	58	43	data	datum	NNS
cord-299882-ee5wathm	58	44	Number	number	NN
cord-299882-ee5wathm	58	45	of	of	IN
cord-299882-ee5wathm	58	46	trials	trial	NNS
cord-299882-ee5wathm	58	47	associated	associate	VBN
cord-299882-ee5wathm	58	48	with	with	IN
cord-299882-ee5wathm	58	49	each	each	DT
cord-299882-ee5wathm	58	50	COVID-19	COVID-19	NNP
cord-299882-ee5wathm	58	51	intervention	intervention	NN
cord-299882-ee5wathm	58	52	.	.	.
cord-299882-ee5wathm	59	1	The	the	DT
cord-299882-ee5wathm	59	2	5	5	CD
cord-299882-ee5wathm	59	3	most	most	RBS
cord-299882-ee5wathm	59	4	frequent	frequent	JJ
cord-299882-ee5wathm	59	5	interventions	intervention	NNS
cord-299882-ee5wathm	59	6	tested	test	VBN
cord-299882-ee5wathm	59	7	are	be	VBP
cord-299882-ee5wathm	59	8	highlighted	highlight	VBN
cord-299882-ee5wathm	59	9	PubMed	PubMed	NNP
cord-299882-ee5wathm	59	10	entries	entry	NNS
cord-299882-ee5wathm	59	11	associated	associate	VBN
cord-299882-ee5wathm	59	12	with	with	IN
cord-299882-ee5wathm	59	13	the	the	DT
cord-299882-ee5wathm	59	14	indicated	indicate	VBN
cord-299882-ee5wathm	59	15	intervention	intervention	NN
cord-299882-ee5wathm	59	16	are	be	VBP
cord-299882-ee5wathm	59	17	shown	show	VBN
cord-299882-ee5wathm	59	18	,	,	,
cord-299882-ee5wathm	59	19	including	include	VBG
cord-299882-ee5wathm	59	20	publications	publication	NNS
cord-299882-ee5wathm	59	21	describing	describe	VBG
cord-299882-ee5wathm	59	22	experiments	experiment	NNS
cord-299882-ee5wathm	59	23	that	that	WDT
cord-299882-ee5wathm	59	24	directly	directly	RB
cord-299882-ee5wathm	59	25	assessed	assess	VBN
cord-299882-ee5wathm	59	26	In	in	IN
cord-299882-ee5wathm	59	27	vitro	vitro	FW
cord-299882-ee5wathm	59	28	or	or	CC
cord-299882-ee5wathm	59	29	in	in	IN
cord-299882-ee5wathm	59	30	vivo	vivo	FW
cord-299882-ee5wathm	59	31	anti	anti	JJ
cord-299882-ee5wathm	59	32	-	-	JJ
cord-299882-ee5wathm	59	33	viral	viral	JJ
cord-299882-ee5wathm	59	34	activity	activity	NN