id sid tid token lemma pos cord-296316-huyw5eo1 1 1 key key NN cord-296316-huyw5eo1 1 2 : : : cord-296316-huyw5eo1 1 3 cord-296316-huyw5eo1 cord-296316-huyw5eo1 VBN cord-296316-huyw5eo1 1 4 authors author NNS cord-296316-huyw5eo1 1 5 : : : cord-296316-huyw5eo1 1 6 Suresh Suresh NNP cord-296316-huyw5eo1 1 7 , , , cord-296316-huyw5eo1 1 8 Padmanaban Padmanaban NNP cord-296316-huyw5eo1 1 9 S. S. NNP cord-296316-huyw5eo1 1 10 title title NN cord-296316-huyw5eo1 1 11 : : : cord-296316-huyw5eo1 1 12 Curcumin Curcumin NNP cord-296316-huyw5eo1 1 13 and and CC cord-296316-huyw5eo1 1 14 Coagulopathy Coagulopathy NNP cord-296316-huyw5eo1 1 15 in in IN cord-296316-huyw5eo1 1 16 the the DT cord-296316-huyw5eo1 1 17 COVID19 COVID19 NNP cord-296316-huyw5eo1 1 18 Era era NN cord-296316-huyw5eo1 1 19 date date NN cord-296316-huyw5eo1 1 20 : : : cord-296316-huyw5eo1 1 21 2020 2020 CD cord-296316-huyw5eo1 1 22 - - HYPH cord-296316-huyw5eo1 1 23 07 07 CD cord-296316-huyw5eo1 1 24 - - SYM cord-296316-huyw5eo1 1 25 15 15 CD cord-296316-huyw5eo1 1 26 journal journal NN cord-296316-huyw5eo1 1 27 : : : cord-296316-huyw5eo1 1 28 Indian Indian NNP cord-296316-huyw5eo1 1 29 J J NNP cord-296316-huyw5eo1 1 30 Clin Clin NNP cord-296316-huyw5eo1 1 31 Biochem Biochem NNP cord-296316-huyw5eo1 1 32 DOI DOI NNP cord-296316-huyw5eo1 1 33 : : : cord-296316-huyw5eo1 1 34 10.1007 10.1007 CD cord-296316-huyw5eo1 1 35 / / SYM cord-296316-huyw5eo1 1 36 s12291 s12291 NNP cord-296316-huyw5eo1 1 37 - - HYPH cord-296316-huyw5eo1 1 38 020 020 CD cord-296316-huyw5eo1 1 39 - - HYPH cord-296316-huyw5eo1 1 40 00914 00914 CD cord-296316-huyw5eo1 1 41 - - SYM cord-296316-huyw5eo1 1 42 5 5 CD cord-296316-huyw5eo1 1 43 sha sha NNP cord-296316-huyw5eo1 1 44 : : : cord-296316-huyw5eo1 1 45 870ea6e7673bb427d58bc4d4d7f3a9514a7b5a0e 870ea6e7673bb427d58bc4d4d7f3a9514a7b5a0e CD cord-296316-huyw5eo1 1 46 doc_id doc_id CD cord-296316-huyw5eo1 1 47 : : : cord-296316-huyw5eo1 1 48 296316 296316 CD cord-296316-huyw5eo1 1 49 cord_uid cord_uid NNS cord-296316-huyw5eo1 1 50 : : : cord-296316-huyw5eo1 1 51 huyw5eo1 huyw5eo1 ADD cord-296316-huyw5eo1 2 1 nan nan NNP cord-296316-huyw5eo1 2 2 I -PRON- PRP cord-296316-huyw5eo1 2 3 read read VBP cord-296316-huyw5eo1 2 4 with with IN cord-296316-huyw5eo1 2 5 great great JJ cord-296316-huyw5eo1 2 6 interest interest NN cord-296316-huyw5eo1 2 7 the the DT cord-296316-huyw5eo1 2 8 article article NN cord-296316-huyw5eo1 2 9 by by IN cord-296316-huyw5eo1 2 10 Manoharan Manoharan NNP cord-296316-huyw5eo1 2 11 et et NNP cord-296316-huyw5eo1 2 12 al al NNP cord-296316-huyw5eo1 2 13 . . NNP cord-296316-huyw5eo1 2 14 , , , cord-296316-huyw5eo1 2 15 2020 2020 CD cord-296316-huyw5eo1 2 16 , , , cord-296316-huyw5eo1 2 17 proposing propose VBG cord-296316-huyw5eo1 2 18 Curcumin Curcumin NNP cord-296316-huyw5eo1 2 19 as as IN cord-296316-huyw5eo1 2 20 supportive supportive JJ cord-296316-huyw5eo1 2 21 therapy therapy NN cord-296316-huyw5eo1 2 22 for for IN cord-296316-huyw5eo1 2 23 COVID-19 COVID-19 NNP cord-296316-huyw5eo1 2 24 disease disease NN cord-296316-huyw5eo1 2 25 published publish VBN cord-296316-huyw5eo1 2 26 in in IN cord-296316-huyw5eo1 2 27 your -PRON- PRP$ cord-296316-huyw5eo1 2 28 journal journal NN cord-296316-huyw5eo1 2 29 [ [ -LRB- cord-296316-huyw5eo1 2 30 1 1 CD cord-296316-huyw5eo1 2 31 ] ] -RRB- cord-296316-huyw5eo1 2 32 . . . cord-296316-huyw5eo1 3 1 I -PRON- PRP cord-296316-huyw5eo1 3 2 want want VBP cord-296316-huyw5eo1 3 3 to to TO cord-296316-huyw5eo1 3 4 highlight highlight VB cord-296316-huyw5eo1 3 5 further far RBR cord-296316-huyw5eo1 3 6 the the DT cord-296316-huyw5eo1 3 7 connection connection NN cord-296316-huyw5eo1 3 8 between between IN cord-296316-huyw5eo1 3 9 COVID-19 COVID-19 NNP cord-296316-huyw5eo1 3 10 associated associated JJ cord-296316-huyw5eo1 3 11 coagulopathies coagulopathie NNS cord-296316-huyw5eo1 3 12 and and CC cord-296316-huyw5eo1 3 13 how how WRB cord-296316-huyw5eo1 3 14 proposing propose VBG cord-296316-huyw5eo1 3 15 curcumin curcumin NN cord-296316-huyw5eo1 3 16 will will MD cord-296316-huyw5eo1 3 17 be be VB cord-296316-huyw5eo1 3 18 beneficial beneficial JJ cord-296316-huyw5eo1 3 19 in in IN cord-296316-huyw5eo1 3 20 this this DT cord-296316-huyw5eo1 3 21 context context NN cord-296316-huyw5eo1 3 22 from from IN cord-296316-huyw5eo1 3 23 the the DT cord-296316-huyw5eo1 3 24 available available JJ cord-296316-huyw5eo1 3 25 literature literature NN cord-296316-huyw5eo1 3 26 knowledge knowledge NN cord-296316-huyw5eo1 3 27 . . . cord-296316-huyw5eo1 4 1 As as IN cord-296316-huyw5eo1 4 2 of of IN cord-296316-huyw5eo1 4 3 Jun Jun NNP cord-296316-huyw5eo1 4 4 18 18 CD cord-296316-huyw5eo1 4 5 , , , cord-296316-huyw5eo1 4 6 2020 2020 CD cord-296316-huyw5eo1 4 7 , , , cord-296316-huyw5eo1 4 8 COVID-19 COVID-19 NNP cord-296316-huyw5eo1 4 9 confirmed confirm VBN cord-296316-huyw5eo1 4 10 cases case NNS cord-296316-huyw5eo1 4 11 are be VBP cord-296316-huyw5eo1 4 12 8 8 CD cord-296316-huyw5eo1 4 13 , , , cord-296316-huyw5eo1 4 14 242 242 CD cord-296316-huyw5eo1 4 15 , , , cord-296316-huyw5eo1 4 16 999 999 CD cord-296316-huyw5eo1 4 17 , , , cord-296316-huyw5eo1 4 18 and and CC cord-296316-huyw5eo1 4 19 445 445 CD cord-296316-huyw5eo1 4 20 , , , cord-296316-huyw5eo1 4 21 535 535 CD cord-296316-huyw5eo1 4 22 deaths death NNS cord-296316-huyw5eo1 4 23 globally globally RB cord-296316-huyw5eo1 4 24 ( ( -LRB- cord-296316-huyw5eo1 4 25 World World NNP cord-296316-huyw5eo1 4 26 Health Health NNP cord-296316-huyw5eo1 4 27 Organization Organization NNP cord-296316-huyw5eo1 4 28 ) ) -RRB- cord-296316-huyw5eo1 4 29 . . . cord-296316-huyw5eo1 5 1 India India NNP cord-296316-huyw5eo1 5 2 reports report VBZ cord-296316-huyw5eo1 5 3 1 1 CD cord-296316-huyw5eo1 5 4 , , , cord-296316-huyw5eo1 5 5 63 63 CD cord-296316-huyw5eo1 5 6 , , , cord-296316-huyw5eo1 5 7 248 248 CD cord-296316-huyw5eo1 5 8 active active JJ cord-296316-huyw5eo1 5 9 cases case NNS cord-296316-huyw5eo1 5 10 and and CC cord-296316-huyw5eo1 5 11 12 12 CD cord-296316-huyw5eo1 5 12 , , , cord-296316-huyw5eo1 5 13 573 573 CD cord-296316-huyw5eo1 5 14 deaths death NNS cord-296316-huyw5eo1 5 15 due due JJ cord-296316-huyw5eo1 5 16 to to IN cord-296316-huyw5eo1 5 17 COVID-19 covid-19 JJ cord-296316-huyw5eo1 5 18 infections infection NNS cord-296316-huyw5eo1 5 19 ( ( -LRB- cord-296316-huyw5eo1 5 20 Ministry Ministry NNP cord-296316-huyw5eo1 5 21 of of IN cord-296316-huyw5eo1 5 22 Health Health NNP cord-296316-huyw5eo1 5 23 and and CC cord-296316-huyw5eo1 5 24 family family NN cord-296316-huyw5eo1 5 25 welfare welfare NN cord-296316-huyw5eo1 5 26 , , , cord-296316-huyw5eo1 5 27 Govt Govt NNP cord-296316-huyw5eo1 5 28 of of IN cord-296316-huyw5eo1 5 29 India India NNP cord-296316-huyw5eo1 5 30 ) ) -RRB- cord-296316-huyw5eo1 5 31 . . . cord-296316-huyw5eo1 6 1 COVID-19 covid-19 JJ cord-296316-huyw5eo1 6 2 patients patient NNS cord-296316-huyw5eo1 6 3 exhibit exhibit VBP cord-296316-huyw5eo1 6 4 thrombotic thrombotic JJ cord-296316-huyw5eo1 6 5 complications complication NNS cord-296316-huyw5eo1 6 6 apart apart RB cord-296316-huyw5eo1 6 7 from from IN cord-296316-huyw5eo1 6 8 sepsis sepsis NN cord-296316-huyw5eo1 6 9 , , , cord-296316-huyw5eo1 6 10 pneumonia pneumonia NN cord-296316-huyw5eo1 6 11 , , , cord-296316-huyw5eo1 6 12 respiratory respiratory JJ cord-296316-huyw5eo1 6 13 failure failure NN cord-296316-huyw5eo1 6 14 , , , cord-296316-huyw5eo1 6 15 etc etc FW cord-296316-huyw5eo1 6 16 . . . cord-296316-huyw5eo1 7 1 , , , cord-296316-huyw5eo1 7 2 One one CD cord-296316-huyw5eo1 7 3 of of IN cord-296316-huyw5eo1 7 4 the the DT cord-296316-huyw5eo1 7 5 characteristic characteristic JJ cord-296316-huyw5eo1 7 6 features feature NNS cord-296316-huyw5eo1 7 7 of of IN cord-296316-huyw5eo1 7 8 COVID-19 covid-19 JJ cord-296316-huyw5eo1 7 9 disease disease NN cord-296316-huyw5eo1 7 10 is be VBZ cord-296316-huyw5eo1 7 11 the the DT cord-296316-huyw5eo1 7 12 associated associated JJ cord-296316-huyw5eo1 7 13 coagulopathy coagulopathy NN cord-296316-huyw5eo1 7 14 with with IN cord-296316-huyw5eo1 7 15 increased increase VBN cord-296316-huyw5eo1 7 16 circulating circulate VBG cord-296316-huyw5eo1 7 17 D d NN cord-296316-huyw5eo1 7 18 - - HYPH cord-296316-huyw5eo1 7 19 dimer dimer NN cord-296316-huyw5eo1 7 20 concentrations concentration NNS cord-296316-huyw5eo1 7 21 . . . cord-296316-huyw5eo1 8 1 D D NNP cord-296316-huyw5eo1 8 2 -dimer -dimer NNP cord-296316-huyw5eo1 8 3 is be VBZ cord-296316-huyw5eo1 8 4 a a DT cord-296316-huyw5eo1 8 5 fibrin fibrin NN cord-296316-huyw5eo1 8 6 degradation degradation NN cord-296316-huyw5eo1 8 7 product product NN cord-296316-huyw5eo1 8 8 that that WDT cord-296316-huyw5eo1 8 9 is be VBZ cord-296316-huyw5eo1 8 10 present present JJ cord-296316-huyw5eo1 8 11 in in IN cord-296316-huyw5eo1 8 12 blood blood NN cord-296316-huyw5eo1 8 13 after after IN cord-296316-huyw5eo1 8 14 blood blood NN cord-296316-huyw5eo1 8 15 clot clot NN cord-296316-huyw5eo1 8 16 fibrinolysis fibrinolysis NN cord-296316-huyw5eo1 8 17 . . . cord-296316-huyw5eo1 9 1 It -PRON- PRP cord-296316-huyw5eo1 9 2 is be VBZ cord-296316-huyw5eo1 9 3 named name VBN cord-296316-huyw5eo1 9 4 because because IN cord-296316-huyw5eo1 9 5 it -PRON- PRP cord-296316-huyw5eo1 9 6 contains contain VBZ cord-296316-huyw5eo1 9 7 fibrin fibrin NN cord-296316-huyw5eo1 9 8 protein protein NN cord-296316-huyw5eo1 9 9 , , , cord-296316-huyw5eo1 9 10 two two CD cord-296316-huyw5eo1 9 11 D d NN cord-296316-huyw5eo1 9 12 fragments fragment NNS cord-296316-huyw5eo1 9 13 joined join VBN cord-296316-huyw5eo1 9 14 by by IN cord-296316-huyw5eo1 9 15 a a DT cord-296316-huyw5eo1 9 16 cross cross NN cord-296316-huyw5eo1 9 17 - - JJ cord-296316-huyw5eo1 9 18 link link NN cord-296316-huyw5eo1 9 19 . . . cord-296316-huyw5eo1 10 1 Evaluating evaluate VBG cord-296316-huyw5eo1 10 2 D d NN cord-296316-huyw5eo1 10 3 - - HYPH cord-296316-huyw5eo1 10 4 dimer dimer NN cord-296316-huyw5eo1 10 5 concentrations concentration NNS cord-296316-huyw5eo1 10 6 assist assist VBP cord-296316-huyw5eo1 10 7 in in IN cord-296316-huyw5eo1 10 8 predicting predict VBG cord-296316-huyw5eo1 10 9 the the DT cord-296316-huyw5eo1 10 10 mortality mortality NN cord-296316-huyw5eo1 10 11 in in IN cord-296316-huyw5eo1 10 12 COVID-19 covid-19 JJ cord-296316-huyw5eo1 10 13 patients patient NNS cord-296316-huyw5eo1 10 14 , , , cord-296316-huyw5eo1 10 15 and and CC cord-296316-huyw5eo1 10 16 patients patient NNS cord-296316-huyw5eo1 10 17 with with IN cord-296316-huyw5eo1 10 18 Ddimer Ddimer NNP cord-296316-huyw5eo1 10 19 levels level NNS cord-296316-huyw5eo1 10 20 [ [ -LRB- cord-296316-huyw5eo1 10 21 1 1 CD cord-296316-huyw5eo1 10 22 lg lg NNP cord-296316-huyw5eo1 10 23 / / SYM cord-296316-huyw5eo1 10 24 L L NNP cord-296316-huyw5eo1 10 25 on on IN cord-296316-huyw5eo1 10 26 admission admission NN cord-296316-huyw5eo1 10 27 were be VBD cord-296316-huyw5eo1 10 28 associated associate VBN cord-296316-huyw5eo1 10 29 with with IN cord-296316-huyw5eo1 10 30 higher high JJR cord-296316-huyw5eo1 10 31 mortality mortality NN cord-296316-huyw5eo1 10 32 [ [ -LRB- cord-296316-huyw5eo1 10 33 2 2 CD cord-296316-huyw5eo1 10 34 ] ] -RRB- cord-296316-huyw5eo1 10 35 [ [ -LRB- cord-296316-huyw5eo1 10 36 3 3 CD cord-296316-huyw5eo1 10 37 ] ] -RRB- cord-296316-huyw5eo1 10 38 [ [ -LRB- cord-296316-huyw5eo1 10 39 4 4 CD cord-296316-huyw5eo1 10 40 ] ] -RRB- cord-296316-huyw5eo1 10 41 . . . cord-296316-huyw5eo1 11 1 There there EX cord-296316-huyw5eo1 11 2 is be VBZ cord-296316-huyw5eo1 11 3 accumulating accumulate VBG cord-296316-huyw5eo1 11 4 evidence evidence NN cord-296316-huyw5eo1 11 5 of of IN cord-296316-huyw5eo1 11 6 COVID-19 COVID-19 NNP cord-296316-huyw5eo1 11 7 associated associated JJ cord-296316-huyw5eo1 11 8 coagulopathies coagulopathie NNS cord-296316-huyw5eo1 11 9 as as IN cord-296316-huyw5eo1 11 10 evident evident JJ cord-296316-huyw5eo1 11 11 by by IN cord-296316-huyw5eo1 11 12 the the DT cord-296316-huyw5eo1 11 13 rising rise VBG cord-296316-huyw5eo1 11 14 number number NN cord-296316-huyw5eo1 11 15 of of IN cord-296316-huyw5eo1 11 16 research research NN cord-296316-huyw5eo1 11 17 publications publication NNS cord-296316-huyw5eo1 11 18 in in IN cord-296316-huyw5eo1 11 19 this this DT cord-296316-huyw5eo1 11 20 context context NN cord-296316-huyw5eo1 11 21 . . . cord-296316-huyw5eo1 12 1 International international JJ cord-296316-huyw5eo1 12 2 society society NN cord-296316-huyw5eo1 12 3 of of IN cord-296316-huyw5eo1 12 4 thrombosis thrombosis NN cord-296316-huyw5eo1 12 5 and and CC cord-296316-huyw5eo1 12 6 hemostasis hemostasis NN cord-296316-huyw5eo1 12 7 proposes propose VBZ cord-296316-huyw5eo1 12 8 an an DT cord-296316-huyw5eo1 12 9 algorithm algorithm NN cord-296316-huyw5eo1 12 10 of of IN cord-296316-huyw5eo1 12 11 measuring measure VBG cord-296316-huyw5eo1 12 12 D d NN cord-296316-huyw5eo1 12 13 - - HYPH cord-296316-huyw5eo1 12 14 dimer dimer NN cord-296316-huyw5eo1 12 15 , , , cord-296316-huyw5eo1 12 16 prothrombin prothrombin JJ cord-296316-huyw5eo1 12 17 time time NN cord-296316-huyw5eo1 12 18 , , , cord-296316-huyw5eo1 12 19 platelet platelet NN cord-296316-huyw5eo1 12 20 count count NN cord-296316-huyw5eo1 12 21 and and CC cord-296316-huyw5eo1 12 22 fibrinogen fibrinogen NN cord-296316-huyw5eo1 12 23 in in IN cord-296316-huyw5eo1 12 24 all all DT cord-296316-huyw5eo1 12 25 patients patient NNS cord-296316-huyw5eo1 12 26 with with IN cord-296316-huyw5eo1 12 27 COVID-19 covid-19 JJ cord-296316-huyw5eo1 12 28 infection infection NN cord-296316-huyw5eo1 12 29 [ [ -LRB- cord-296316-huyw5eo1 12 30 5 5 CD cord-296316-huyw5eo1 12 31 ] ] -RRB- cord-296316-huyw5eo1 12 32 . . . cord-296316-huyw5eo1 13 1 Markedly markedly RB cord-296316-huyw5eo1 13 2 raised raise VBN cord-296316-huyw5eo1 13 3 D d NN cord-296316-huyw5eo1 13 4 - - HYPH cord-296316-huyw5eo1 13 5 dimer dimer NN cord-296316-huyw5eo1 13 6 ( ( -LRB- cord-296316-huyw5eo1 13 7 maybe maybe RB cord-296316-huyw5eo1 13 8 3 3 CD cord-296316-huyw5eo1 13 9 - - SYM cord-296316-huyw5eo1 13 10 4 4 CD cord-296316-huyw5eo1 13 11 fold fold VB cord-296316-huyw5eo1 13 12 increase increase NN cord-296316-huyw5eo1 13 13 ) ) -RRB- cord-296316-huyw5eo1 13 14 prolonged prolong VBN cord-296316-huyw5eo1 13 15 prothrombin prothrombin NN cord-296316-huyw5eo1 13 16 time time NN cord-296316-huyw5eo1 13 17 , , , cord-296316-huyw5eo1 13 18 platelet platelet NN cord-296316-huyw5eo1 13 19 count count NN cord-296316-huyw5eo1 13 20 ( ( -LRB- cord-296316-huyw5eo1 13 21 100 100 CD cord-296316-huyw5eo1 13 22 9 9 CD cord-296316-huyw5eo1 13 23 10 10 CD cord-296316-huyw5eo1 13 24 9 9 CD cord-296316-huyw5eo1 13 25 /L /l CD cord-296316-huyw5eo1 13 26 ) ) -RRB- cord-296316-huyw5eo1 13 27 , , , cord-296316-huyw5eo1 13 28 fibrinogen fibrinogen NN cord-296316-huyw5eo1 13 29 ( ( -LRB- cord-296316-huyw5eo1 13 30 \ \ NN cord-296316-huyw5eo1 13 31 2 2 CD cord-296316-huyw5eo1 13 32 g g NN cord-296316-huyw5eo1 13 33 / / SYM cord-296316-huyw5eo1 13 34 L L NNP cord-296316-huyw5eo1 13 35 ) ) -RRB- cord-296316-huyw5eo1 13 36 are be VBP cord-296316-huyw5eo1 13 37 guiding guide VBG cord-296316-huyw5eo1 13 38 parameters parameter NNS cord-296316-huyw5eo1 13 39 in in IN cord-296316-huyw5eo1 13 40 the the DT cord-296316-huyw5eo1 13 41 management management NN cord-296316-huyw5eo1 13 42 of of IN cord-296316-huyw5eo1 13 43 COVID-19 COVID-19 NNP cord-296316-huyw5eo1 13 44 patients patient NNS cord-296316-huyw5eo1 13 45 . . . cord-296316-huyw5eo1 14 1 Two two CD cord-296316-huyw5eo1 14 2 hypotheses hypothesis NNS cord-296316-huyw5eo1 14 3 can can MD cord-296316-huyw5eo1 14 4 explain explain VB cord-296316-huyw5eo1 14 5 the the DT cord-296316-huyw5eo1 14 6 hypercoagulable hypercoagulable JJ cord-296316-huyw5eo1 14 7 state state NN cord-296316-huyw5eo1 14 8 and and CC cord-296316-huyw5eo1 14 9 secondary secondary JJ cord-296316-huyw5eo1 14 10 hyperfibrinolysis hyperfibrinolysis NN cord-296316-huyw5eo1 14 11 in in IN cord-296316-huyw5eo1 14 12 vivo vivo NNP cord-296316-huyw5eo1 14 13 leading lead VBG cord-296316-huyw5eo1 14 14 to to IN cord-296316-huyw5eo1 14 15 coagulopathies coagulopathie NNS cord-296316-huyw5eo1 14 16 during during IN cord-296316-huyw5eo1 14 17 COVID-19 covid-19 CD cord-296316-huyw5eo1 14 18 infection infection NN cord-296316-huyw5eo1 14 19 . . . cord-296316-huyw5eo1 15 1 One one CD cord-296316-huyw5eo1 15 2 is be VBZ cord-296316-huyw5eo1 15 3 the the DT cord-296316-huyw5eo1 15 4 elevated elevated JJ cord-296316-huyw5eo1 15 5 proinflammatory proinflammatory JJ cord-296316-huyw5eo1 15 6 cytokines cytokine NNS cord-296316-huyw5eo1 15 7 ( ( -LRB- cord-296316-huyw5eo1 15 8 IL-6 IL-6 NNP cord-296316-huyw5eo1 15 9 , , , cord-296316-huyw5eo1 15 10 IL-1 IL-1 NNP cord-296316-huyw5eo1 15 11 , , , cord-296316-huyw5eo1 15 12 and and CC cord-296316-huyw5eo1 15 13 TNFa TNFa NNP cord-296316-huyw5eo1 15 14 ) ) -RRB- cord-296316-huyw5eo1 15 15 , , , cord-296316-huyw5eo1 15 16 leading lead VBG cord-296316-huyw5eo1 15 17 to to IN cord-296316-huyw5eo1 15 18 microvasculature microvasculature NN cord-296316-huyw5eo1 15 19 damage damage NN cord-296316-huyw5eo1 15 20 and and CC cord-296316-huyw5eo1 15 21 endothelial endothelial JJ cord-296316-huyw5eo1 15 22 dysfunction dysfunction NN cord-296316-huyw5eo1 15 23 in in IN cord-296316-huyw5eo1 15 24 the the DT cord-296316-huyw5eo1 15 25 lungs lung NNS cord-296316-huyw5eo1 15 26 , , , cord-296316-huyw5eo1 15 27 causing cause VBG cord-296316-huyw5eo1 15 28 hemostasis hemostasis NN cord-296316-huyw5eo1 15 29 derangements derangement NNS cord-296316-huyw5eo1 15 30 and and CC cord-296316-huyw5eo1 15 31 pulmonary pulmonary JJ cord-296316-huyw5eo1 15 32 thrombi thrombi NN cord-296316-huyw5eo1 15 33 . . . cord-296316-huyw5eo1 16 1 The the DT cord-296316-huyw5eo1 16 2 other other JJ cord-296316-huyw5eo1 16 3 alternative alternative JJ cord-296316-huyw5eo1 16 4 hypothesis hypothesis NN cord-296316-huyw5eo1 16 5 is be VBZ cord-296316-huyw5eo1 16 6 the the DT cord-296316-huyw5eo1 16 7 direct direct JJ cord-296316-huyw5eo1 16 8 or or CC cord-296316-huyw5eo1 16 9 indirect indirect JJ cord-296316-huyw5eo1 16 10 effect effect NN cord-296316-huyw5eo1 16 11 of of IN cord-296316-huyw5eo1 16 12 the the DT cord-296316-huyw5eo1 16 13 virus virus NN cord-296316-huyw5eo1 16 14 on on IN cord-296316-huyw5eo1 16 15 coagulation coagulation NN cord-296316-huyw5eo1 16 16 pathways pathway NNS cord-296316-huyw5eo1 16 17 causing cause VBG cord-296316-huyw5eo1 16 18 systemic systemic JJ cord-296316-huyw5eo1 16 19 thrombosis thrombosis NN cord-296316-huyw5eo1 16 20 [ [ -LRB- cord-296316-huyw5eo1 16 21 6 6 CD cord-296316-huyw5eo1 16 22 ] ] -RRB- cord-296316-huyw5eo1 16 23 . . . cord-296316-huyw5eo1 17 1 Antiviral antiviral JJ cord-296316-huyw5eo1 17 2 treatments treatment NNS cord-296316-huyw5eo1 17 3 are be VBP cord-296316-huyw5eo1 17 4 generally generally RB cord-296316-huyw5eo1 17 5 useful useful JJ cord-296316-huyw5eo1 17 6 and and CC cord-296316-huyw5eo1 17 7 benefit benefit VBP cord-296316-huyw5eo1 17 8 patients patient NNS cord-296316-huyw5eo1 17 9 ; ; : cord-296316-huyw5eo1 17 10 however however RB cord-296316-huyw5eo1 17 11 , , , cord-296316-huyw5eo1 17 12 treatment treatment NN cord-296316-huyw5eo1 17 13 strategies strategy NNS cord-296316-huyw5eo1 17 14 that that WDT cord-296316-huyw5eo1 17 15 counteract counteract VBP cord-296316-huyw5eo1 17 16 inflammation inflammation NN cord-296316-huyw5eo1 17 17 and and CC cord-296316-huyw5eo1 17 18 coagulopathies coagulopathie NNS cord-296316-huyw5eo1 17 19 may may MD cord-296316-huyw5eo1 17 20 be be VB cord-296316-huyw5eo1 17 21 more more RBR cord-296316-huyw5eo1 17 22 promising promising JJ cord-296316-huyw5eo1 17 23 for for IN cord-296316-huyw5eo1 17 24 COVID-19 covid-19 JJ cord-296316-huyw5eo1 17 25 patients patient NNS cord-296316-huyw5eo1 17 26 . . . cord-296316-huyw5eo1 18 1 Curcumin curcumin NN cord-296316-huyw5eo1 18 2 is be VBZ cord-296316-huyw5eo1 18 3 a a DT cord-296316-huyw5eo1 18 4 natural natural JJ cord-296316-huyw5eo1 18 5 compound compound NN cord-296316-huyw5eo1 18 6 that that WDT cord-296316-huyw5eo1 18 7 exhibits exhibit VBZ cord-296316-huyw5eo1 18 8 antiviral antiviral JJ cord-296316-huyw5eo1 18 9 , , , cord-296316-huyw5eo1 18 10 antiinflammatory antiinflammatory JJ cord-296316-huyw5eo1 18 11 properties property NNS cord-296316-huyw5eo1 18 12 , , , cord-296316-huyw5eo1 18 13 etc etc FW cord-296316-huyw5eo1 18 14 . . . cord-296316-huyw5eo1 19 1 [ [ -LRB- cord-296316-huyw5eo1 19 2 1 1 CD cord-296316-huyw5eo1 19 3 ] ] -RRB- cord-296316-huyw5eo1 19 4 , , , cord-296316-huyw5eo1 19 5 and and CC cord-296316-huyw5eo1 19 6 the the DT cord-296316-huyw5eo1 19 7 research research NN cord-296316-huyw5eo1 19 8 community community NN cord-296316-huyw5eo1 19 9 is be VBZ cord-296316-huyw5eo1 19 10 continuously continuously RB cord-296316-huyw5eo1 19 11 making make VBG cord-296316-huyw5eo1 19 12 an an DT cord-296316-huyw5eo1 19 13 impressive impressive JJ cord-296316-huyw5eo1 19 14 effort effort NN cord-296316-huyw5eo1 19 15 to to TO cord-296316-huyw5eo1 19 16 understand understand VB cord-296316-huyw5eo1 19 17 curcumin curcumin NN cord-296316-huyw5eo1 19 18 benefits benefit NNS cord-296316-huyw5eo1 19 19 as as IN cord-296316-huyw5eo1 19 20 an an DT cord-296316-huyw5eo1 19 21 alternative alternative JJ cord-296316-huyw5eo1 19 22 and and CC cord-296316-huyw5eo1 19 23 complementary complementary JJ cord-296316-huyw5eo1 19 24 medicine medicine NN cord-296316-huyw5eo1 19 25 . . . cord-296316-huyw5eo1 20 1 Investigators investigator NNS cord-296316-huyw5eo1 20 2 have have VBP cord-296316-huyw5eo1 20 3 explored explore VBN cord-296316-huyw5eo1 20 4 the the DT cord-296316-huyw5eo1 20 5 antithrombotic antithrombotic JJ cord-296316-huyw5eo1 20 6 activities activity NNS cord-296316-huyw5eo1 20 7 of of IN cord-296316-huyw5eo1 20 8 Curcumin curcumin NN cord-296316-huyw5eo1 20 9 and and CC cord-296316-huyw5eo1 20 10 mitigating mitigate VBG cord-296316-huyw5eo1 20 11 effect effect NN cord-296316-huyw5eo1 20 12 on on IN cord-296316-huyw5eo1 20 13 thrombosis thrombosis NN cord-296316-huyw5eo1 20 14 by by IN cord-296316-huyw5eo1 20 15 modulating modulate VBG cord-296316-huyw5eo1 20 16 platelet platelet NN cord-296316-huyw5eo1 20 17 numbers number NNS cord-296316-huyw5eo1 20 18 , , , cord-296316-huyw5eo1 20 19 D d NN cord-296316-huyw5eo1 20 20 - - HYPH cord-296316-huyw5eo1 20 21 dimer dimer NN cord-296316-huyw5eo1 20 22 and and CC cord-296316-huyw5eo1 20 23 plasminogen plasminogen NN cord-296316-huyw5eo1 20 24 activator activator NN cord-296316-huyw5eo1 20 25 inhibitor inhibitor NN cord-296316-huyw5eo1 20 26 -1 -1 VBN cord-296316-huyw5eo1 20 27 in in IN cord-296316-huyw5eo1 20 28 mice mouse NNS cord-296316-huyw5eo1 20 29 [ [ -LRB- cord-296316-huyw5eo1 20 30 7 7 CD cord-296316-huyw5eo1 20 31 ] ] -RRB- cord-296316-huyw5eo1 20 32 [ [ -LRB- cord-296316-huyw5eo1 20 33 8 8 CD cord-296316-huyw5eo1 20 34 ] ] -RRB- cord-296316-huyw5eo1 20 35 [ [ -LRB- cord-296316-huyw5eo1 20 36 9 9 CD cord-296316-huyw5eo1 20 37 ] ] -RRB- cord-296316-huyw5eo1 20 38 . . . cord-296316-huyw5eo1 21 1 COVID-19 covid-19 JJ cord-296316-huyw5eo1 21 2 patients patient NNS cord-296316-huyw5eo1 21 3 show show VBP cord-296316-huyw5eo1 21 4 improvement improvement NN cord-296316-huyw5eo1 21 5 on on IN cord-296316-huyw5eo1 21 6 treatment treatment NN cord-296316-huyw5eo1 21 7 with with IN cord-296316-huyw5eo1 21 8 low low JJ cord-296316-huyw5eo1 21 9 molecular molecular JJ cord-296316-huyw5eo1 21 10 weight weight NN cord-296316-huyw5eo1 21 11 heparin heparin NN cord-296316-huyw5eo1 21 12 that that WDT cord-296316-huyw5eo1 21 13 acts act VBZ cord-296316-huyw5eo1 21 14 as as IN cord-296316-huyw5eo1 21 15 an an DT cord-296316-huyw5eo1 21 16 anticoagulant anticoagulant JJ cord-296316-huyw5eo1 21 17 and and CC cord-296316-huyw5eo1 21 18 antiinflammatory antiinflammatory JJ cord-296316-huyw5eo1 21 19 agent agent NN cord-296316-huyw5eo1 21 20 and and CC cord-296316-huyw5eo1 21 21 various various JJ cord-296316-huyw5eo1 21 22 other other JJ cord-296316-huyw5eo1 21 23 anticoagulants anticoagulant NNS cord-296316-huyw5eo1 21 24 are be VBP cord-296316-huyw5eo1 21 25 being be VBG cord-296316-huyw5eo1 21 26 tried try VBN cord-296316-huyw5eo1 21 27 in in IN cord-296316-huyw5eo1 21 28 the the DT cord-296316-huyw5eo1 21 29 management management NN cord-296316-huyw5eo1 21 30 of of IN cord-296316-huyw5eo1 21 31 thrombotic thrombotic JJ cord-296316-huyw5eo1 21 32 complications complication NNS cord-296316-huyw5eo1 21 33 . . . cord-296316-huyw5eo1 22 1 Can Can MD cord-296316-huyw5eo1 22 2 Curcumin curcumin NN cord-296316-huyw5eo1 22 3 being be VBG cord-296316-huyw5eo1 22 4 a a DT cord-296316-huyw5eo1 22 5 natural natural JJ cord-296316-huyw5eo1 22 6 product product NN cord-296316-huyw5eo1 22 7 be be VB cord-296316-huyw5eo1 22 8 used use VBN cord-296316-huyw5eo1 22 9 as as IN cord-296316-huyw5eo1 22 10 an an DT cord-296316-huyw5eo1 22 11 adjunct adjunct NN cord-296316-huyw5eo1 22 12 to to IN cord-296316-huyw5eo1 22 13 the the DT cord-296316-huyw5eo1 22 14 above above JJ cord-296316-huyw5eo1 22 15 treatments treatment NNS cord-296316-huyw5eo1 22 16 ? ? . cord-296316-huyw5eo1 23 1 As as IN cord-296316-huyw5eo1 23 2 such such JJ cord-296316-huyw5eo1 23 3 therapeutic therapeutic JJ cord-296316-huyw5eo1 23 4 potential potential NN cord-296316-huyw5eo1 23 5 of of IN cord-296316-huyw5eo1 23 6 Curcumin Curcumin NNP cord-296316-huyw5eo1 23 7 is be VBZ cord-296316-huyw5eo1 23 8 explored explore VBN cord-296316-huyw5eo1 23 9 in in IN cord-296316-huyw5eo1 23 10 various various JJ cord-296316-huyw5eo1 23 11 clinical clinical JJ cord-296316-huyw5eo1 23 12 trials trial NNS cord-296316-huyw5eo1 23 13 , , , cord-296316-huyw5eo1 23 14 the the DT cord-296316-huyw5eo1 23 15 untapped untapped JJ cord-296316-huyw5eo1 23 16 potential potential NN cord-296316-huyw5eo1 23 17 of of IN cord-296316-huyw5eo1 23 18 Curcumin Curcumin NNP cord-296316-huyw5eo1 23 19 as as IN cord-296316-huyw5eo1 23 20 an an DT cord-296316-huyw5eo1 23 21 antithrombotic antithrombotic JJ cord-296316-huyw5eo1 23 22 agent agent NN cord-296316-huyw5eo1 23 23 in in IN cord-296316-huyw5eo1 23 24 COVID-19 COVID-19 NNP cord-296316-huyw5eo1 23 25 associated associated JJ cord-296316-huyw5eo1 23 26 coagulopathies coagulopathie NNS cord-296316-huyw5eo1 23 27 is be VBZ cord-296316-huyw5eo1 23 28 desirable desirable JJ cord-296316-huyw5eo1 23 29 . . . cord-296316-huyw5eo1 24 1 & & CC cord-296316-huyw5eo1 24 2 Padmanaban Padmanaban NNP cord-296316-huyw5eo1 24 3 S. S. NNP cord-296316-huyw5eo1 24 4 Suresh Suresh NNP cord-296316-huyw5eo1 24 5 surepadman@gmail.com surepadman@gmail.com ADD cord-296316-huyw5eo1 25 1 ; ; : cord-296316-huyw5eo1 25 2 surepadman@rediffmail.com surepadman@rediffmail.com ADD cord-296316-huyw5eo1 25 3 Curcumin Curcumin NNP cord-296316-huyw5eo1 25 4 : : : cord-296316-huyw5eo1 25 5 a a DT cord-296316-huyw5eo1 25 6 Wonder Wonder NNP cord-296316-huyw5eo1 25 7 Drug Drug NNP cord-296316-huyw5eo1 25 8 as as IN cord-296316-huyw5eo1 25 9 a a DT cord-296316-huyw5eo1 25 10 Preventive Preventive NNP cord-296316-huyw5eo1 25 11 Measure measure NN cord-296316-huyw5eo1 25 12 for for IN cord-296316-huyw5eo1 25 13 COVID19 COVID19 NNP cord-296316-huyw5eo1 25 14 Management Management NNP cord-296316-huyw5eo1 25 15 D d NN cord-296316-huyw5eo1 25 16 - - HYPH cord-296316-huyw5eo1 25 17 dimer dimer NN cord-296316-huyw5eo1 25 18 levels level NNS cord-296316-huyw5eo1 25 19 on on IN cord-296316-huyw5eo1 25 20 admission admission NN cord-296316-huyw5eo1 25 21 to to TO cord-296316-huyw5eo1 25 22 predict predict VB cord-296316-huyw5eo1 25 23 in in IN cord-296316-huyw5eo1 25 24 - - HYPH cord-296316-huyw5eo1 25 25 hospital hospital NN cord-296316-huyw5eo1 25 26 mortality mortality NN cord-296316-huyw5eo1 25 27 in in IN cord-296316-huyw5eo1 25 28 patients patient NNS cord-296316-huyw5eo1 25 29 with with IN cord-296316-huyw5eo1 25 30 Covid-19 Covid-19 NNP cord-296316-huyw5eo1 25 31 Clinical clinical JJ cord-296316-huyw5eo1 25 32 features feature NNS cord-296316-huyw5eo1 25 33 of of IN cord-296316-huyw5eo1 25 34 patients patient NNS cord-296316-huyw5eo1 25 35 infected infect VBN cord-296316-huyw5eo1 25 36 with with IN cord-296316-huyw5eo1 25 37 2019 2019 CD cord-296316-huyw5eo1 25 38 novel novel JJ cord-296316-huyw5eo1 25 39 coronavirus coronavirus NN cord-296316-huyw5eo1 25 40 in in IN cord-296316-huyw5eo1 25 41 Wuhan Wuhan NNP cord-296316-huyw5eo1 25 42 Clinical Clinical NNP cord-296316-huyw5eo1 25 43 course course NN cord-296316-huyw5eo1 25 44 and and CC cord-296316-huyw5eo1 25 45 risk risk NN cord-296316-huyw5eo1 25 46 factors factor NNS cord-296316-huyw5eo1 25 47 for for IN cord-296316-huyw5eo1 25 48 mortality mortality NN cord-296316-huyw5eo1 25 49 of of IN cord-296316-huyw5eo1 25 50 adult adult NN cord-296316-huyw5eo1 25 51 inpatients inpatient NNS cord-296316-huyw5eo1 25 52 with with IN cord-296316-huyw5eo1 25 53 COVID-19 COVID-19 NNP cord-296316-huyw5eo1 25 54 in in IN cord-296316-huyw5eo1 25 55 Wuhan Wuhan NNP cord-296316-huyw5eo1 25 56 , , , cord-296316-huyw5eo1 25 57 China China NNP cord-296316-huyw5eo1 25 58 : : : cord-296316-huyw5eo1 26 1 a a DT cord-296316-huyw5eo1 26 2 retrospective retrospective JJ cord-296316-huyw5eo1 26 3 cohort cohort NN cord-296316-huyw5eo1 26 4 study study NN cord-296316-huyw5eo1 26 5 ISTH ISTH NNP cord-296316-huyw5eo1 26 6 interim interim JJ cord-296316-huyw5eo1 26 7 guidance guidance NN cord-296316-huyw5eo1 26 8 on on IN cord-296316-huyw5eo1 26 9 recognition recognition NN cord-296316-huyw5eo1 26 10 and and CC cord-296316-huyw5eo1 26 11 management management NN cord-296316-huyw5eo1 26 12 of of IN cord-296316-huyw5eo1 26 13 coagulopathy coagulopathy NN cord-296316-huyw5eo1 26 14 in in IN cord-296316-huyw5eo1 26 15 COVID-19 COVID-19 NNP cord-296316-huyw5eo1 26 16 COVID-19 COVID-19 NNP cord-296316-huyw5eo1 26 17 coagulopathy coagulopathy NN cord-296316-huyw5eo1 26 18 : : : cord-296316-huyw5eo1 26 19 an an DT cord-296316-huyw5eo1 26 20 evolving evolve VBG cord-296316-huyw5eo1 26 21 story story NN cord-296316-huyw5eo1 26 22 Anticoagulant anticoagulant JJ cord-296316-huyw5eo1 26 23 activities activity NNS cord-296316-huyw5eo1 26 24 of of IN cord-296316-huyw5eo1 26 25 curcumin curcumin NN cord-296316-huyw5eo1 26 26 and and CC cord-296316-huyw5eo1 26 27 its -PRON- PRP$ cord-296316-huyw5eo1 26 28 derivative derivative JJ cord-296316-huyw5eo1 26 29 Protective protective JJ cord-296316-huyw5eo1 26 30 effect effect NN cord-296316-huyw5eo1 26 31 of of IN cord-296316-huyw5eo1 26 32 curcumin curcumin NN cord-296316-huyw5eo1 26 33 on on IN cord-296316-huyw5eo1 26 34 pulmonary pulmonary JJ cord-296316-huyw5eo1 26 35 and and CC cord-296316-huyw5eo1 26 36 cardiovascular cardiovascular JJ cord-296316-huyw5eo1 26 37 effects effect NNS cord-296316-huyw5eo1 26 38 induced induce VBN cord-296316-huyw5eo1 26 39 by by IN cord-296316-huyw5eo1 26 40 repeated repeat VBN cord-296316-huyw5eo1 26 41 exposure exposure NN cord-296316-huyw5eo1 26 42 to to IN cord-296316-huyw5eo1 26 43 diesel diesel NN cord-296316-huyw5eo1 26 44 exhaust exhaust NN cord-296316-huyw5eo1 26 45 particles particle NNS cord-296316-huyw5eo1 26 46 in in IN cord-296316-huyw5eo1 26 47 mice mouse NNS cord-296316-huyw5eo1 26 48 Curcumin curcumin NN cord-296316-huyw5eo1 26 49 , , , cord-296316-huyw5eo1 26 50 hemostasis hemostasis NN cord-296316-huyw5eo1 26 51 , , , cord-296316-huyw5eo1 26 52 thrombosis thrombosis NN cord-296316-huyw5eo1 26 53 , , , cord-296316-huyw5eo1 26 54 and and CC cord-296316-huyw5eo1 26 55 coagulation coagulation NN