id	sid	tid	token	lemma	pos
cord-290677-3gdcyrrz	1	1	key	key	JJ
cord-290677-3gdcyrrz	1	2	:	:	:
cord-290677-3gdcyrrz	1	3	cord-290677	cord-290677	NNP
cord-290677-3gdcyrrz	1	4	-	-	HYPH
cord-290677-3gdcyrrz	1	5	3gdcyrrz	3gdcyrrz	CD
cord-290677-3gdcyrrz	1	6	authors	author	NNS
cord-290677-3gdcyrrz	1	7	:	:	:
cord-290677-3gdcyrrz	1	8	De	De	NNP
cord-290677-3gdcyrrz	1	9	Virgiliis	Virgiliis	NNP
cord-290677-3gdcyrrz	1	10	,	,	,
cord-290677-3gdcyrrz	1	11	Francesco	Francesco	NNP
cord-290677-3gdcyrrz	1	12	;	;	:
cord-290677-3gdcyrrz	1	13	Di	Di	NNP
cord-290677-3gdcyrrz	1	14	Giovanni	Giovanni	NNP
cord-290677-3gdcyrrz	1	15	,	,	,
cord-290677-3gdcyrrz	1	16	Simone	Simone	NNP
cord-290677-3gdcyrrz	1	17	title	title	NN
cord-290677-3gdcyrrz	1	18	:	:	:
cord-290677-3gdcyrrz	1	19	Lung	lung	NN
cord-290677-3gdcyrrz	1	20	innervation	innervation	NN
cord-290677-3gdcyrrz	1	21	in	in	IN
cord-290677-3gdcyrrz	1	22	the	the	DT
cord-290677-3gdcyrrz	1	23	eye	eye	NN
cord-290677-3gdcyrrz	1	24	of	of	IN
cord-290677-3gdcyrrz	1	25	a	a	DT
cord-290677-3gdcyrrz	1	26	cytokine	cytokine	NN
cord-290677-3gdcyrrz	1	27	storm	storm	NN
cord-290677-3gdcyrrz	1	28	:	:	:
cord-290677-3gdcyrrz	1	29	neuroimmune	neuroimmune	NNP
cord-290677-3gdcyrrz	1	30	interactions	interaction	NNS
cord-290677-3gdcyrrz	1	31	and	and	CC
cord-290677-3gdcyrrz	1	32	COVID-19	covid-19	CD
cord-290677-3gdcyrrz	1	33	date	date	NN
cord-290677-3gdcyrrz	1	34	:	:	:
cord-290677-3gdcyrrz	1	35	2020	2020	CD
cord-290677-3gdcyrrz	1	36	-	-	HYPH
cord-290677-3gdcyrrz	1	37	08	08	CD
cord-290677-3gdcyrrz	1	38	-	-	SYM
cord-290677-3gdcyrrz	1	39	25	25	CD
cord-290677-3gdcyrrz	1	40	journal	journal	NN
cord-290677-3gdcyrrz	1	41	:	:	:
cord-290677-3gdcyrrz	2	1	Nat	Nat	NNP
cord-290677-3gdcyrrz	2	2	Rev	Rev	NNP
cord-290677-3gdcyrrz	2	3	Neurol	Neurol	NNP
cord-290677-3gdcyrrz	2	4	DOI	DOI	NNP
cord-290677-3gdcyrrz	2	5	:	:	:
cord-290677-3gdcyrrz	2	6	10.1038	10.1038	CD
cord-290677-3gdcyrrz	2	7	/	/	SYM
cord-290677-3gdcyrrz	2	8	s41582	s41582	CD
cord-290677-3gdcyrrz	2	9	-	-	HYPH
cord-290677-3gdcyrrz	2	10	020	020	CD
cord-290677-3gdcyrrz	3	1	-0402-y	-0402-y	NNPS
cord-290677-3gdcyrrz	3	2	sha	sha	NNP
cord-290677-3gdcyrrz	3	3	:	:	:
cord-290677-3gdcyrrz	4	1	79d168a2dbf95780988feea63c2b2fd90b1bb14c	79d168a2dbf95780988feea63c2b2fd90b1bb14c	CD
cord-290677-3gdcyrrz	4	2	doc_id	doc_id	CD
cord-290677-3gdcyrrz	5	1	:	:	:
cord-290677-3gdcyrrz	5	2	290677	290677	CD
cord-290677-3gdcyrrz	5	3	cord_uid	cord_uid	NNS
cord-290677-3gdcyrrz	5	4	:	:	:
cord-290677-3gdcyrrz	6	1	3gdcyrrz	3gdcyrrz	LS
cord-290677-3gdcyrrz	7	1	COVID-19	COVID-19	NNP
cord-290677-3gdcyrrz	7	2	is	be	VBZ
cord-290677-3gdcyrrz	7	3	an	an	DT
cord-290677-3gdcyrrz	7	4	infectious	infectious	JJ
cord-290677-3gdcyrrz	7	5	disease	disease	NN
cord-290677-3gdcyrrz	7	6	caused	cause	VBN
cord-290677-3gdcyrrz	7	7	by	by	IN
cord-290677-3gdcyrrz	7	8	the	the	DT
cord-290677-3gdcyrrz	7	9	coronavirus	coronavirus	NN
cord-290677-3gdcyrrz	7	10	SARS	SARS	NNP
cord-290677-3gdcyrrz	7	11	-	-	HYPH
cord-290677-3gdcyrrz	7	12	CoV-2	CoV-2	NNP
cord-290677-3gdcyrrz	7	13	,	,	,
cord-290677-3gdcyrrz	7	14	which	which	WDT
cord-290677-3gdcyrrz	7	15	was	be	VBD
cord-290677-3gdcyrrz	7	16	first	first	RB
cord-290677-3gdcyrrz	7	17	reported	report	VBN
cord-290677-3gdcyrrz	7	18	in	in	IN
cord-290677-3gdcyrrz	7	19	Wuhan	Wuhan	NNP
cord-290677-3gdcyrrz	7	20	,	,	,
cord-290677-3gdcyrrz	7	21	China	China	NNP
cord-290677-3gdcyrrz	7	22	,	,	,
cord-290677-3gdcyrrz	7	23	in	in	IN
cord-290677-3gdcyrrz	7	24	December	December	NNP
cord-290677-3gdcyrrz	7	25	2019	2019	CD
cord-290677-3gdcyrrz	7	26	and	and	CC
cord-290677-3gdcyrrz	7	27	has	have	VBZ
cord-290677-3gdcyrrz	7	28	caused	cause	VBN
cord-290677-3gdcyrrz	7	29	a	a	DT
cord-290677-3gdcyrrz	7	30	global	global	JJ
cord-290677-3gdcyrrz	7	31	pandemic	pandemic	NN
cord-290677-3gdcyrrz	7	32	.	.	.
cord-290677-3gdcyrrz	8	1	Acute	acute	JJ
cord-290677-3gdcyrrz	8	2	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	8	3	distress	distress	NN
cord-290677-3gdcyrrz	8	4	syndrome	syndrome	NN
cord-290677-3gdcyrrz	8	5	(	(	-LRB-
cord-290677-3gdcyrrz	8	6	ARDS	ARDS	NNP
cord-290677-3gdcyrrz	8	7	)	)	-RRB-
cord-290677-3gdcyrrz	8	8	is	be	VBZ
cord-290677-3gdcyrrz	8	9	a	a	DT
cord-290677-3gdcyrrz	8	10	common	common	JJ
cord-290677-3gdcyrrz	8	11	feature	feature	NN
cord-290677-3gdcyrrz	8	12	of	of	IN
cord-290677-3gdcyrrz	8	13	severe	severe	JJ
cord-290677-3gdcyrrz	8	14	forms	form	NNS
cord-290677-3gdcyrrz	8	15	of	of	IN
cord-290677-3gdcyrrz	8	16	COVID-19	covid-19	NN
cord-290677-3gdcyrrz	8	17	and	and	CC
cord-290677-3gdcyrrz	8	18	can	can	MD
cord-290677-3gdcyrrz	8	19	lead	lead	VB
cord-290677-3gdcyrrz	8	20	to	to	IN
cord-290677-3gdcyrrz	8	21	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	8	22	failure	failure	NN
cord-290677-3gdcyrrz	8	23	,	,	,
cord-290677-3gdcyrrz	8	24	especially	especially	RB
cord-290677-3gdcyrrz	8	25	in	in	IN
cord-290677-3gdcyrrz	8	26	older	old	JJR
cord-290677-3gdcyrrz	8	27	individuals	individual	NNS
cord-290677-3gdcyrrz	8	28	.	.	.
cord-290677-3gdcyrrz	9	1	The	the	DT
cord-290677-3gdcyrrz	9	2	increasing	increase	VBG
cord-290677-3gdcyrrz	9	3	recognition	recognition	NN
cord-290677-3gdcyrrz	9	4	of	of	IN
cord-290677-3gdcyrrz	9	5	the	the	DT
cord-290677-3gdcyrrz	9	6	neurotropic	neurotropic	NNP
cord-290677-3gdcyrrz	9	7	potential	potential	NN
cord-290677-3gdcyrrz	9	8	of	of	IN
cord-290677-3gdcyrrz	9	9	SARS	SARS	NNP
cord-290677-3gdcyrrz	9	10	-	-	HYPH
cord-290677-3gdcyrrz	9	11	CoV-2	CoV-2	NNP
cord-290677-3gdcyrrz	9	12	has	have	VBZ
cord-290677-3gdcyrrz	9	13	sparked	spark	VBN
cord-290677-3gdcyrrz	9	14	interest	interest	NN
cord-290677-3gdcyrrz	9	15	in	in	IN
cord-290677-3gdcyrrz	9	16	the	the	DT
cord-290677-3gdcyrrz	9	17	role	role	NN
cord-290677-3gdcyrrz	9	18	of	of	IN
cord-290677-3gdcyrrz	9	19	the	the	DT
cord-290677-3gdcyrrz	9	20	nervous	nervous	JJ
cord-290677-3gdcyrrz	9	21	system	system	NN
cord-290677-3gdcyrrz	9	22	in	in	IN
cord-290677-3gdcyrrz	9	23	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	9	24	failure	failure	NN
cord-290677-3gdcyrrz	9	25	in	in	IN
cord-290677-3gdcyrrz	9	26	people	people	NNS
cord-290677-3gdcyrrz	9	27	with	with	IN
cord-290677-3gdcyrrz	9	28	COVID-19	COVID-19	NNP
cord-290677-3gdcyrrz	9	29	.	.	.
cord-290677-3gdcyrrz	10	1	However	however	RB
cord-290677-3gdcyrrz	10	2	,	,	,
cord-290677-3gdcyrrz	10	3	the	the	DT
cord-290677-3gdcyrrz	10	4	neuroimmune	neuroimmune	NNP
cord-290677-3gdcyrrz	10	5	interactions	interaction	NNS
cord-290677-3gdcyrrz	10	6	in	in	IN
cord-290677-3gdcyrrz	10	7	the	the	DT
cord-290677-3gdcyrrz	10	8	lung	lung	NN
cord-290677-3gdcyrrz	10	9	in	in	IN
cord-290677-3gdcyrrz	10	10	the	the	DT
cord-290677-3gdcyrrz	10	11	context	context	NN
cord-290677-3gdcyrrz	10	12	of	of	IN
cord-290677-3gdcyrrz	10	13	ARDS	ARDS	NNP
cord-290677-3gdcyrrz	10	14	are	be	VBP
cord-290677-3gdcyrrz	10	15	poorly	poorly	RB
cord-290677-3gdcyrrz	10	16	understood	understand	VBN
cord-290677-3gdcyrrz	10	17	.	.	.
cord-290677-3gdcyrrz	11	1	In	in	IN
cord-290677-3gdcyrrz	11	2	this	this	DT
cord-290677-3gdcyrrz	11	3	Perspectives	Perspectives	NNPS
cord-290677-3gdcyrrz	11	4	article	article	NN
cord-290677-3gdcyrrz	11	5	,	,	,
cord-290677-3gdcyrrz	11	6	we	-PRON-	PRP
cord-290677-3gdcyrrz	11	7	propose	propose	VBP
cord-290677-3gdcyrrz	11	8	the	the	DT
cord-290677-3gdcyrrz	11	9	concept	concept	NN
cord-290677-3gdcyrrz	11	10	of	of	IN
cord-290677-3gdcyrrz	11	11	the	the	DT
cord-290677-3gdcyrrz	11	12	neuroimmune	neuroimmune	NNP
cord-290677-3gdcyrrz	11	13	unit	unit	NN
cord-290677-3gdcyrrz	11	14	as	as	IN
cord-290677-3gdcyrrz	11	15	a	a	DT
cord-290677-3gdcyrrz	11	16	critical	critical	JJ
cord-290677-3gdcyrrz	11	17	determinant	determinant	NN
cord-290677-3gdcyrrz	11	18	of	of	IN
cord-290677-3gdcyrrz	11	19	lung	lung	NN
cord-290677-3gdcyrrz	11	20	function	function	NN
cord-290677-3gdcyrrz	11	21	in	in	IN
cord-290677-3gdcyrrz	11	22	the	the	DT
cord-290677-3gdcyrrz	11	23	context	context	NN
cord-290677-3gdcyrrz	11	24	of	of	IN
cord-290677-3gdcyrrz	11	25	COVID-19	COVID-19	NNP
cord-290677-3gdcyrrz	11	26	,	,	,
cord-290677-3gdcyrrz	11	27	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	11	28	conditions	condition	NNS
cord-290677-3gdcyrrz	11	29	and	and	CC
cord-290677-3gdcyrrz	11	30	ageing	ageing	NN
cord-290677-3gdcyrrz	11	31	,	,	,
cord-290677-3gdcyrrz	11	32	focusing	focus	VBG
cord-290677-3gdcyrrz	11	33	particularly	particularly	RB
cord-290677-3gdcyrrz	11	34	on	on	IN
cord-290677-3gdcyrrz	11	35	the	the	DT
cord-290677-3gdcyrrz	11	36	involvement	involvement	NN
cord-290677-3gdcyrrz	11	37	of	of	IN
cord-290677-3gdcyrrz	11	38	the	the	DT
cord-290677-3gdcyrrz	11	39	vagus	vagus	NN
cord-290677-3gdcyrrz	11	40	nerve	nerve	NN
cord-290677-3gdcyrrz	11	41	.	.	.
cord-290677-3gdcyrrz	12	1	We	-PRON-	PRP
cord-290677-3gdcyrrz	12	2	discuss	discuss	VBP
cord-290677-3gdcyrrz	12	3	approaches	approach	NNS
cord-290677-3gdcyrrz	12	4	such	such	JJ
cord-290677-3gdcyrrz	12	5	as	as	IN
cord-290677-3gdcyrrz	12	6	neurostimulation	neurostimulation	JJ
cord-290677-3gdcyrrz	12	7	and	and	CC
cord-290677-3gdcyrrz	12	8	pharmacological	pharmacological	JJ
cord-290677-3gdcyrrz	12	9	neuromodulation	neuromodulation	NN
cord-290677-3gdcyrrz	12	10	to	to	TO
cord-290677-3gdcyrrz	12	11	reduce	reduce	VB
cord-290677-3gdcyrrz	12	12	tissue	tissue	NN
cord-290677-3gdcyrrz	12	13	inflammation	inflammation	NN
cord-290677-3gdcyrrz	12	14	with	with	IN
cord-290677-3gdcyrrz	12	15	the	the	DT
cord-290677-3gdcyrrz	12	16	aim	aim	NN
cord-290677-3gdcyrrz	12	17	of	of	IN
cord-290677-3gdcyrrz	12	18	preventing	prevent	VBG
cord-290677-3gdcyrrz	12	19	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	12	20	failure	failure	NN
cord-290677-3gdcyrrz	12	21	.	.	.
cord-290677-3gdcyrrz	13	1	NL63	NL63	NNP
cord-290677-3gdcyrrz	13	2	and	and	CC
cord-290677-3gdcyrrz	13	3	HKU1	HKU1	NNP
cord-290677-3gdcyrrz	13	4	,	,	,
cord-290677-3gdcyrrz	13	5	cause	cause	VB
cord-290677-3gdcyrrz	13	6	mild	mild	JJ
cord-290677-3gdcyrrz	13	7	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	13	8	diseases	disease	NNS
cord-290677-3gdcyrrz	13	9	.	.	.
cord-290677-3gdcyrrz	14	1	However	however	RB
cord-290677-3gdcyrrz	14	2	,	,	,
cord-290677-3gdcyrrz	14	3	the	the	DT
cord-290677-3gdcyrrz	14	4	worldwide	worldwide	JJ
cord-290677-3gdcyrrz	14	5	spread	spread	NN
cord-290677-3gdcyrrz	14	6	of	of	IN
cord-290677-3gdcyrrz	14	7	two	two	CD
cord-290677-3gdcyrrz	14	8	previously	previously	RB
cord-290677-3gdcyrrz	14	9	unrecognized	unrecognized	JJ
cord-290677-3gdcyrrz	14	10	viruses	virus	NNS
cord-290677-3gdcyrrz	14	11	,	,	,
cord-290677-3gdcyrrz	14	12	the	the	DT
cord-290677-3gdcyrrz	14	13	severe	severe	JJ
cord-290677-3gdcyrrz	14	14	acute	acute	JJ
cord-290677-3gdcyrrz	14	15	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	14	16	syndrome	syndrome	NN
cord-290677-3gdcyrrz	14	17	coronavirus	coronavirus	NN
cord-290677-3gdcyrrz	14	18	(	(	-LRB-
cord-290677-3gdcyrrz	14	19	SARS	SARS	NNP
cord-290677-3gdcyrrz	14	20	-	-	HYPH
cord-290677-3gdcyrrz	14	21	CoV	CoV	NNP
cord-290677-3gdcyrrz	14	22	)	)	-RRB-
cord-290677-3gdcyrrz	14	23	and	and	CC
cord-290677-3gdcyrrz	14	24	Middle	Middle	NNP
cord-290677-3gdcyrrz	14	25	East	East	NNP
cord-290677-3gdcyrrz	14	26	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	14	27	syndrome	syndrome	NN
cord-290677-3gdcyrrz	14	28	coronavirus	coronavirus	NN
cord-290677-3gdcyrrz	14	29	(	(	-LRB-
cord-290677-3gdcyrrz	14	30	MERS	MERS	NNP
cord-290677-3gdcyrrz	14	31	-	-	HYPH
cord-290677-3gdcyrrz	14	32	CoV	CoV	NNP
cord-290677-3gdcyrrz	14	33	)	)	-RRB-
cord-290677-3gdcyrrz	14	34	,	,	,
cord-290677-3gdcyrrz	14	35	revealed	reveal	VBD
cord-290677-3gdcyrrz	14	36	to	to	IN
cord-290677-3gdcyrrz	14	37	the	the	DT
cord-290677-3gdcyrrz	14	38	world	world	NN
cord-290677-3gdcyrrz	14	39	the	the	DT
cord-290677-3gdcyrrz	14	40	lethal	lethal	JJ
cord-290677-3gdcyrrz	14	41	potential	potential	NN
cord-290677-3gdcyrrz	14	42	of	of	IN
cord-290677-3gdcyrrz	14	43	human	human	JJ
cord-290677-3gdcyrrz	14	44	coronaviruses	coronaviruse	NNS
cord-290677-3gdcyrrz	14	45	1	1	CD
cord-290677-3gdcyrrz	14	46	.	.	.
cord-290677-3gdcyrrz	15	1	Another	another	DT
cord-290677-3gdcyrrz	15	2	highly	highly	RB
cord-290677-3gdcyrrz	15	3	pathogenic	pathogenic	JJ
cord-290677-3gdcyrrz	15	4	coronavirus	coronavirus	NN
cord-290677-3gdcyrrz	15	5	,	,	,
cord-290677-3gdcyrrz	15	6	which	which	WDT
cord-290677-3gdcyrrz	15	7	has	have	VBZ
cord-290677-3gdcyrrz	15	8	been	be	VBN
cord-290677-3gdcyrrz	15	9	named	name	VBN
cord-290677-3gdcyrrz	15	10	SARS	SARS	NNP
cord-290677-3gdcyrrz	15	11	-	-	HYPH
cord-290677-3gdcyrrz	15	12	CoV-2	CoV-2	NNP
cord-290677-3gdcyrrz	15	13	and	and	CC
cord-290677-3gdcyrrz	15	14	causes	cause	VBZ
cord-290677-3gdcyrrz	15	15	a	a	DT
cord-290677-3gdcyrrz	15	16	disease	disease	NN
cord-290677-3gdcyrrz	15	17	known	know	VBN
cord-290677-3gdcyrrz	15	18	as	as	IN
cord-290677-3gdcyrrz	15	19	COVID-19	COVID-19	NNP
cord-290677-3gdcyrrz	15	20	,	,	,
cord-290677-3gdcyrrz	15	21	was	be	VBD
cord-290677-3gdcyrrz	15	22	reported	report	VBN
cord-290677-3gdcyrrz	15	23	in	in	IN
cord-290677-3gdcyrrz	15	24	December	December	NNP
cord-290677-3gdcyrrz	15	25	2019	2019	CD
cord-290677-3gdcyrrz	15	26	in	in	IN
cord-290677-3gdcyrrz	15	27	Wuhan	Wuhan	NNP
cord-290677-3gdcyrrz	15	28	,	,	,
cord-290677-3gdcyrrz	15	29	China	China	NNP
cord-290677-3gdcyrrz	15	30	2	2	CD
cord-290677-3gdcyrrz	15	31	.	.	.
cord-290677-3gdcyrrz	16	1	This	this	DT
cord-290677-3gdcyrrz	16	2	novel	novel	JJ
cord-290677-3gdcyrrz	16	3	virus	virus	NN
cord-290677-3gdcyrrz	16	4	caused	cause	VBD
cord-290677-3gdcyrrz	16	5	a	a	DT
cord-290677-3gdcyrrz	16	6	national	national	JJ
cord-290677-3gdcyrrz	16	7	outbreak	outbreak	NN
cord-290677-3gdcyrrz	16	8	of	of	IN
cord-290677-3gdcyrrz	16	9	severe	severe	JJ
cord-290677-3gdcyrrz	16	10	pneumonia	pneumonia	NN
cord-290677-3gdcyrrz	16	11	in	in	IN
cord-290677-3gdcyrrz	16	12	China	China	NNP
cord-290677-3gdcyrrz	16	13	and	and	CC
cord-290677-3gdcyrrz	16	14	has	have	VBZ
cord-290677-3gdcyrrz	16	15	rapidly	rapidly	RB
cord-290677-3gdcyrrz	16	16	spread	spread	VBN
cord-290677-3gdcyrrz	16	17	around	around	IN
cord-290677-3gdcyrrz	16	18	the	the	DT
cord-290677-3gdcyrrz	16	19	world	world	NN
cord-290677-3gdcyrrz	16	20	owing	owe	VBG
cord-290677-3gdcyrrz	16	21	to	to	IN
cord-290677-3gdcyrrz	16	22	its	-PRON-	PRP$
cord-290677-3gdcyrrz	16	23	high	high	JJ
cord-290677-3gdcyrrz	16	24	infectivity	infectivity	NN
cord-290677-3gdcyrrz	16	25	,	,	,
cord-290677-3gdcyrrz	16	26	causing	cause	VBG
cord-290677-3gdcyrrz	16	27	a	a	DT
cord-290677-3gdcyrrz	16	28	global	global	JJ
cord-290677-3gdcyrrz	16	29	pandemic	pandemic	NN
cord-290677-3gdcyrrz	16	30	.	.	.
cord-290677-3gdcyrrz	17	1	SARS	SARS	NNP
cord-290677-3gdcyrrz	17	2	-	-	HYPH
cord-290677-3gdcyrrz	17	3	CoV-2	CoV-2	NNP
cord-290677-3gdcyrrz	17	4	can	can	MD
cord-290677-3gdcyrrz	17	5	cause	cause	VB
cord-290677-3gdcyrrz	17	6	acute	acute	JJ
cord-290677-3gdcyrrz	17	7	,	,	,
cord-290677-3gdcyrrz	17	8	highly	highly	RB
cord-290677-3gdcyrrz	17	9	lethal	lethal	JJ
cord-290677-3gdcyrrz	17	10	pneumonia	pneumonia	NN
cord-290677-3gdcyrrz	17	11	with	with	IN
cord-290677-3gdcyrrz	17	12	clinical	clinical	JJ
cord-290677-3gdcyrrz	17	13	symptoms	symptom	NNS
cord-290677-3gdcyrrz	17	14	similar	similar	JJ
cord-290677-3gdcyrrz	17	15	to	to	IN
cord-290677-3gdcyrrz	17	16	those	those	DT
cord-290677-3gdcyrrz	17	17	reported	report	VBN
cord-290677-3gdcyrrz	17	18	for	for	IN
cord-290677-3gdcyrrz	17	19	SARS	SARS	NNP
cord-290677-3gdcyrrz	17	20	-	-	HYPH
cord-290677-3gdcyrrz	17	21	CoV	CoV	NNP
cord-290677-3gdcyrrz	17	22	and	and	CC
cord-290677-3gdcyrrz	17	23	MERS	MERS	NNP
cord-290677-3gdcyrrz	17	24	-	-	HYPH
cord-290677-3gdcyrrz	17	25	CoV	CoV	NNP
cord-290677-3gdcyrrz	17	26	1	1	CD
cord-290677-3gdcyrrz	17	27	.	.	.
cord-290677-3gdcyrrz	18	1	A	a	DT
cord-290677-3gdcyrrz	18	2	substantial	substantial	JJ
cord-290677-3gdcyrrz	18	3	proportion	proportion	NN
cord-290677-3gdcyrrz	18	4	of	of	IN
cord-290677-3gdcyrrz	18	5	patients	patient	NNS
cord-290677-3gdcyrrz	18	6	who	who	WP
cord-290677-3gdcyrrz	18	7	are	be	VBP
cord-290677-3gdcyrrz	18	8	admitted	admit	VBN
cord-290677-3gdcyrrz	18	9	to	to	IN
cord-290677-3gdcyrrz	18	10	intensive	intensive	JJ
cord-290677-3gdcyrrz	18	11	care	care	NN
cord-290677-3gdcyrrz	18	12	units	unit	NNS
cord-290677-3gdcyrrz	18	13	worsen	worsen	VBP
cord-290677-3gdcyrrz	18	14	in	in	IN
cord-290677-3gdcyrrz	18	15	a	a	DT
cord-290677-3gdcyrrz	18	16	short	short	JJ
cord-290677-3gdcyrrz	18	17	period	period	NN
cord-290677-3gdcyrrz	18	18	of	of	IN
cord-290677-3gdcyrrz	18	19	time	time	NN
cord-290677-3gdcyrrz	18	20	and	and	CC
cord-290677-3gdcyrrz	18	21	die	die	VB
cord-290677-3gdcyrrz	18	22	from	from	IN
cord-290677-3gdcyrrz	18	23	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	18	24	failure	failure	NN
cord-290677-3gdcyrrz	18	25	1	1	CD
cord-290677-3gdcyrrz	18	26	.	.	.
cord-290677-3gdcyrrz	19	1	to	to	IN
cord-290677-3gdcyrrz	19	2	infection	infection	NN
cord-290677-3gdcyrrz	19	3	.	.	.
cord-290677-3gdcyrrz	20	1	Interestingly	interestingly	RB
cord-290677-3gdcyrrz	20	2	,	,	,
cord-290677-3gdcyrrz	20	3	ACE2	ACE2	NNP
cord-290677-3gdcyrrz	20	4	is	be	VBZ
cord-290677-3gdcyrrz	20	5	expressed	express	VBN
cord-290677-3gdcyrrz	20	6	in	in	IN
cord-290677-3gdcyrrz	20	7	nuclei	nucleus	NNS
cord-290677-3gdcyrrz	20	8	involved	involve	VBN
cord-290677-3gdcyrrz	20	9	in	in	IN
cord-290677-3gdcyrrz	20	10	the	the	DT
cord-290677-3gdcyrrz	20	11	central	central	JJ
cord-290677-3gdcyrrz	20	12	regulation	regulation	NN
cord-290677-3gdcyrrz	20	13	of	of	IN
cord-290677-3gdcyrrz	20	14	cardiovascular	cardiovascular	JJ
cord-290677-3gdcyrrz	20	15	and	and	CC
cord-290677-3gdcyrrz	20	16	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	20	17	functions	function	NNS
cord-290677-3gdcyrrz	20	18	,	,	,
cord-290677-3gdcyrrz	20	19	such	such	JJ
cord-290677-3gdcyrrz	20	20	as	as	IN
cord-290677-3gdcyrrz	20	21	the	the	DT
cord-290677-3gdcyrrz	20	22	paraventricular	paraventricular	NNP
cord-290677-3gdcyrrz	20	23	nucleus	nucleus	NNP
cord-290677-3gdcyrrz	20	24	,	,	,
cord-290677-3gdcyrrz	20	25	the	the	DT
cord-290677-3gdcyrrz	20	26	nucleus	nucleus	NN
cord-290677-3gdcyrrz	20	27	of	of	IN
cord-290677-3gdcyrrz	20	28	the	the	DT
cord-290677-3gdcyrrz	20	29	tractus	tractus	NNP
cord-290677-3gdcyrrz	20	30	solitarius	solitarius	NN
cord-290677-3gdcyrrz	20	31	(	(	-LRB-
cord-290677-3gdcyrrz	20	32	NTS	NTS	NNP
cord-290677-3gdcyrrz	20	33	)	)	-RRB-
cord-290677-3gdcyrrz	20	34	and	and	CC
cord-290677-3gdcyrrz	20	35	the	the	DT
cord-290677-3gdcyrrz	20	36	rostral	rostral	JJ
cord-290677-3gdcyrrz	20	37	ventrolateral	ventrolateral	JJ
cord-290677-3gdcyrrz	20	38	medulla	medulla	NN
cord-290677-3gdcyrrz	20	39	,	,	,
cord-290677-3gdcyrrz	20	40	as	as	RB
cord-290677-3gdcyrrz	20	41	well	well	RB
cord-290677-3gdcyrrz	20	42	as	as	IN
cord-290677-3gdcyrrz	20	43	in	in	IN
cord-290677-3gdcyrrz	20	44	the	the	DT
cord-290677-3gdcyrrz	20	45	motor	motor	NN
cord-290677-3gdcyrrz	20	46	cortex	cortex	NN
cord-290677-3gdcyrrz	20	47	and	and	CC
cord-290677-3gdcyrrz	20	48	raphe	raphe	NNP
cord-290677-3gdcyrrz	20	49	17	17	CD
cord-290677-3gdcyrrz	20	50	.	.	.
cord-290677-3gdcyrrz	21	1	In	in	IN
cord-290677-3gdcyrrz	21	2	this	this	DT
cord-290677-3gdcyrrz	21	3	Perspective	perspective	NN
cord-290677-3gdcyrrz	21	4	,	,	,
cord-290677-3gdcyrrz	21	5	we	-PRON-	PRP
cord-290677-3gdcyrrz	21	6	briefly	briefly	RB
cord-290677-3gdcyrrz	21	7	summarize	summarize	VBP
cord-290677-3gdcyrrz	21	8	our	-PRON-	PRP$
cord-290677-3gdcyrrz	21	9	current	current	JJ
cord-290677-3gdcyrrz	21	10	knowledge	knowledge	NN
cord-290677-3gdcyrrz	21	11	regarding	regard	VBG
cord-290677-3gdcyrrz	21	12	the	the	DT
cord-290677-3gdcyrrz	21	13	immune	immune	JJ
cord-290677-3gdcyrrz	21	14	response	response	NN
cord-290677-3gdcyrrz	21	15	to	to	IN
cord-290677-3gdcyrrz	21	16	SARS	SARS	NNP
cord-290677-3gdcyrrz	21	17	-	-	HYPH
cord-290677-3gdcyrrz	21	18	CoV-2	CoV-2	NNP
cord-290677-3gdcyrrz	21	19	.	.	.
cord-290677-3gdcyrrz	22	1	We	-PRON-	PRP
cord-290677-3gdcyrrz	22	2	then	then	RB
cord-290677-3gdcyrrz	22	3	consider	consider	VBP
cord-290677-3gdcyrrz	22	4	how	how	WRB
cord-290677-3gdcyrrz	22	5	lung	lung	NN
cord-290677-3gdcyrrz	22	6	afferent	afferent	NN
cord-290677-3gdcyrrz	22	7	and	and	CC
cord-290677-3gdcyrrz	22	8	efferent	efferent	JJ
cord-290677-3gdcyrrz	22	9	innervation	innervation	NN
cord-290677-3gdcyrrz	22	10	might	may	MD
cord-290677-3gdcyrrz	22	11	crosstalk	crosstalk	VB
cord-290677-3gdcyrrz	22	12	with	with	IN
cord-290677-3gdcyrrz	22	13	the	the	DT
cord-290677-3gdcyrrz	22	14	immune	immune	JJ
cord-290677-3gdcyrrz	22	15	system	system	NN
cord-290677-3gdcyrrz	22	16	to	to	TO
cord-290677-3gdcyrrz	22	17	modulate	modulate	VB
cord-290677-3gdcyrrz	22	18	lung	lung	NN
cord-290677-3gdcyrrz	22	19	function	function	NN
cord-290677-3gdcyrrz	22	20	,	,	,
cord-290677-3gdcyrrz	22	21	thereby	thereby	RB
cord-290677-3gdcyrrz	22	22	critically	critically	RB
cord-290677-3gdcyrrz	22	23	affecting	affect	VBG
cord-290677-3gdcyrrz	22	24	clinical	clinical	JJ
cord-290677-3gdcyrrz	22	25	outcomes	outcome	NNS
cord-290677-3gdcyrrz	22	26	following	follow	VBG
cord-290677-3gdcyrrz	22	27	SARS	SARS	NNP
cord-290677-3gdcyrrz	22	28	-	-	HYPH
cord-290677-3gdcyrrz	22	29	CoV-2	CoV-2	NNP
cord-290677-3gdcyrrz	22	30	infection	infection	NN
cord-290677-3gdcyrrz	22	31	.	.	.
cord-290677-3gdcyrrz	23	1	The	the	DT
cord-290677-3gdcyrrz	23	2	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	23	3	tract	tract	NN
cord-290677-3gdcyrrz	23	4	is	be	VBZ
cord-290677-3gdcyrrz	23	5	a	a	DT
cord-290677-3gdcyrrz	23	6	major	major	JJ
cord-290677-3gdcyrrz	23	7	barrier	barrier	NN
cord-290677-3gdcyrrz	23	8	tissue	tissue	NN
cord-290677-3gdcyrrz	23	9	and	and	CC
cord-290677-3gdcyrrz	23	10	is	be	VBZ
cord-290677-3gdcyrrz	23	11	often	often	RB
cord-290677-3gdcyrrz	23	12	the	the	DT
cord-290677-3gdcyrrz	23	13	first	first	JJ
cord-290677-3gdcyrrz	23	14	point	point	NN
cord-290677-3gdcyrrz	23	15	of	of	IN
cord-290677-3gdcyrrz	23	16	contact	contact	NN
cord-290677-3gdcyrrz	23	17	and	and	CC
cord-290677-3gdcyrrz	23	18	entry	entry	NN
cord-290677-3gdcyrrz	23	19	for	for	IN
cord-290677-3gdcyrrz	23	20	harmful	harmful	JJ
cord-290677-3gdcyrrz	23	21	substances	substance	NNS
cord-290677-3gdcyrrz	23	22	and	and	CC
cord-290677-3gdcyrrz	23	23	pathogens	pathogen	NNS
cord-290677-3gdcyrrz	23	24	,	,	,
cord-290677-3gdcyrrz	23	25	including	include	VBG
cord-290677-3gdcyrrz	23	26	viruses	virus	NNS
cord-290677-3gdcyrrz	23	27	.	.	.
cord-290677-3gdcyrrz	24	1	Alveolar	alveolar	JJ
cord-290677-3gdcyrrz	24	2	epithelial	epithelial	JJ
cord-290677-3gdcyrrz	24	3	cells	cell	NNS
cord-290677-3gdcyrrz	24	4	are	be	VBP
cord-290677-3gdcyrrz	24	5	important	important	JJ
cord-290677-3gdcyrrz	24	6	cellular	cellular	JJ
cord-290677-3gdcyrrz	24	7	targets	target	NNS
cord-290677-3gdcyrrz	24	8	for	for	IN
cord-290677-3gdcyrrz	24	9	SARS	SARS	NNP
cord-290677-3gdcyrrz	24	10	-	-	HYPH
cord-290677-3gdcyrrz	24	11	CoVs	CoVs	NNP
cord-290677-3gdcyrrz	24	12	and	and	CC
cord-290677-3gdcyrrz	24	13	the	the	DT
cord-290677-3gdcyrrz	24	14	avian	avian	JJ
cord-290677-3gdcyrrz	24	15	H5N1	H5N1	NNP
cord-290677-3gdcyrrz	24	16	virus	virus	NN
cord-290677-3gdcyrrz	24	17	18	18	CD
cord-290677-3gdcyrrz	24	18	,	,	,
cord-290677-3gdcyrrz	24	19	19	19	CD
cord-290677-3gdcyrrz	24	20	,	,	,
cord-290677-3gdcyrrz	24	21	which	which	WDT
cord-290677-3gdcyrrz	24	22	elicit	elicit	VBP
cord-290677-3gdcyrrz	24	23	a	a	DT
cord-290677-3gdcyrrz	24	24	prompt	prompt	JJ
cord-290677-3gdcyrrz	24	25	immune	immune	JJ
cord-290677-3gdcyrrz	24	26	response	response	NN
cord-290677-3gdcyrrz	24	27	.	.	.
cord-290677-3gdcyrrz	25	1	While	while	IN
cord-290677-3gdcyrrz	25	2	attempting	attempt	VBG
cord-290677-3gdcyrrz	25	3	to	to	TO
cord-290677-3gdcyrrz	25	4	eliminate	eliminate	VB
cord-290677-3gdcyrrz	25	5	the	the	DT
cord-290677-3gdcyrrz	25	6	virus	virus	NN
cord-290677-3gdcyrrz	25	7	,	,	,
cord-290677-3gdcyrrz	25	8	this	this	DT
cord-290677-3gdcyrrz	25	9	response	response	NN
cord-290677-3gdcyrrz	25	10	can	can	MD
cord-290677-3gdcyrrz	25	11	compromise	compromise	VB
cord-290677-3gdcyrrz	25	12	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	25	13	function	function	NN
cord-290677-3gdcyrrz	25	14	owing	owe	VBG
cord-290677-3gdcyrrz	25	15	to	to	IN
cord-290677-3gdcyrrz	25	16	excessive	excessive	JJ
cord-290677-3gdcyrrz	25	17	tissue	tissue	NN
cord-290677-3gdcyrrz	25	18	inflammation	inflammation	NN
cord-290677-3gdcyrrz	25	19	,	,	,
cord-290677-3gdcyrrz	25	20	leading	lead	VBG
cord-290677-3gdcyrrz	25	21	to	to	IN
cord-290677-3gdcyrrz	25	22	acute	acute	JJ
cord-290677-3gdcyrrz	25	23	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	25	24	distress	distress	NN
cord-290677-3gdcyrrz	25	25	syndrome	syndrome	NN
cord-290677-3gdcyrrz	25	26	(	(	-LRB-
cord-290677-3gdcyrrz	25	27	ARDS	ARDS	NNP
cord-290677-3gdcyrrz	25	28	)	)	-RRB-
cord-290677-3gdcyrrz	25	29	.	.	.
cord-290677-3gdcyrrz	26	1	The	the	DT
cord-290677-3gdcyrrz	26	2	first	first	JJ
cord-290677-3gdcyrrz	26	3	immune	immune	JJ
cord-290677-3gdcyrrz	26	4	cell	cell	NN
cord-290677-3gdcyrrz	26	5	types	type	NNS
cord-290677-3gdcyrrz	26	6	to	to	TO
cord-290677-3gdcyrrz	26	7	encounter	encounter	VB
cord-290677-3gdcyrrz	26	8	viral	viral	JJ
cord-290677-3gdcyrrz	26	9	antigens	antigen	NNS
cord-290677-3gdcyrrz	26	10	in	in	IN
cord-290677-3gdcyrrz	26	11	the	the	DT
cord-290677-3gdcyrrz	26	12	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	26	13	tract	tract	NN
cord-290677-3gdcyrrz	26	14	are	be	VBP
cord-290677-3gdcyrrz	26	15	the	the	DT
cord-290677-3gdcyrrz	26	16	alveolar	alveolar	JJ
cord-290677-3gdcyrrz	26	17	and	and	CC
cord-290677-3gdcyrrz	26	18	interstitial	interstitial	JJ
cord-290677-3gdcyrrz	26	19	macrophages	macrophage	NNS
cord-290677-3gdcyrrz	26	20	,	,	,
cord-290677-3gdcyrrz	26	21	which	which	WDT
cord-290677-3gdcyrrz	26	22	are	be	VBP
cord-290677-3gdcyrrz	26	23	capable	capable	JJ
cord-290677-3gdcyrrz	26	24	of	of	IN
cord-290677-3gdcyrrz	26	25	eliminating	eliminate	VBG
cord-290677-3gdcyrrz	26	26	many	many	JJ
cord-290677-3gdcyrrz	26	27	different	different	JJ
cord-290677-3gdcyrrz	26	28	pathogens	pathogen	NNS
cord-290677-3gdcyrrz	26	29	from	from	IN
cord-290677-3gdcyrrz	26	30	the	the	DT
cord-290677-3gdcyrrz	26	31	lungs	lung	NNS
cord-290677-3gdcyrrz	26	32	by	by	IN
cord-290677-3gdcyrrz	26	33	phagocytosis	phagocytosis	NN
cord-290677-3gdcyrrz	26	34	.	.	.
cord-290677-3gdcyrrz	27	1	In	in	IN
cord-290677-3gdcyrrz	27	2	addition	addition	NN
cord-290677-3gdcyrrz	27	3	,	,	,
cord-290677-3gdcyrrz	27	4	interstitial	interstitial	JJ
cord-290677-3gdcyrrz	27	5	macrophages	macrophage	NNS
cord-290677-3gdcyrrz	27	6	seem	seem	VBP
cord-290677-3gdcyrrz	27	7	to	to	TO
cord-290677-3gdcyrrz	27	8	be	be	VB
cord-290677-3gdcyrrz	27	9	involved	involve	VBN
cord-290677-3gdcyrrz	27	10	in	in	IN
cord-290677-3gdcyrrz	27	11	dampening	dampen	VBG
cord-290677-3gdcyrrz	27	12	the	the	DT
cord-290677-3gdcyrrz	27	13	immune	immune	JJ
cord-290677-3gdcyrrz	27	14	response	response	NN
cord-290677-3gdcyrrz	27	15	in	in	IN
cord-290677-3gdcyrrz	27	16	loco	loco	NN
cord-290677-3gdcyrrz	27	17	after	after	IN
cord-290677-3gdcyrrz	27	18	influenza	influenza	NN
cord-290677-3gdcyrrz	27	19	virus	virus	NN
cord-290677-3gdcyrrz	27	20	infection	infection	NN
cord-290677-3gdcyrrz	27	21	20	20	CD
cord-290677-3gdcyrrz	27	22	,	,	,
cord-290677-3gdcyrrz	27	23	21	21	CD
cord-290677-3gdcyrrz	27	24	.	.	.
cord-290677-3gdcyrrz	28	1	Dendritic	dendritic	JJ
cord-290677-3gdcyrrz	28	2	cells	cell	NNS
cord-290677-3gdcyrrz	28	3	are	be	VBP
cord-290677-3gdcyrrz	28	4	the	the	DT
cord-290677-3gdcyrrz	28	5	primary	primary	JJ
cord-290677-3gdcyrrz	28	6	antigen	antigen	NN
cord-290677-3gdcyrrz	28	7	-	-	HYPH
cord-290677-3gdcyrrz	28	8	presenting	present	VBG
cord-290677-3gdcyrrz	28	9	cells	cell	NNS
cord-290677-3gdcyrrz	28	10	(	(	-LRB-
cord-290677-3gdcyrrz	28	11	APCs	apc	NNS
cord-290677-3gdcyrrz	28	12	)	)	-RRB-
cord-290677-3gdcyrrz	28	13	,	,	,
cord-290677-3gdcyrrz	28	14	and	and	CC
cord-290677-3gdcyrrz	28	15	resident	resident	NN
cord-290677-3gdcyrrz	28	16	mature	mature	VB
cord-290677-3gdcyrrz	28	17	MHCII	MHCII	NNP
cord-290677-3gdcyrrz	29	1	hi	hi	UH
cord-290677-3gdcyrrz	29	2	CD11c	CD11c	NNP
cord-290677-3gdcyrrz	30	1	hi	hi	UH
cord-290677-3gdcyrrz	30	2	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	30	3	dendritic	dendritic	JJ
cord-290677-3gdcyrrz	30	4	cells	cell	NNS
cord-290677-3gdcyrrz	30	5	are	be	VBP
cord-290677-3gdcyrrz	30	6	crucial	crucial	JJ
cord-290677-3gdcyrrz	30	7	for	for	IN
cord-290677-3gdcyrrz	30	8	the	the	DT
cord-290677-3gdcyrrz	30	9	induction	induction	NN
cord-290677-3gdcyrrz	30	10	of	of	IN
cord-290677-3gdcyrrz	30	11	adaptive	adaptive	JJ
cord-290677-3gdcyrrz	30	12	immune	immune	JJ
cord-290677-3gdcyrrz	30	13	responses	response	NNS
cord-290677-3gdcyrrz	30	14	.	.	.
cord-290677-3gdcyrrz	31	1	Plasmacytoid	Plasmacytoid	NNP
cord-290677-3gdcyrrz	31	2	dendritic	dendritic	JJ
cord-290677-3gdcyrrz	31	3	cells	cell	NNS
cord-290677-3gdcyrrz	31	4	are	be	VBP
cord-290677-3gdcyrrz	31	5	also	also	RB
cord-290677-3gdcyrrz	31	6	recognized	recognize	VBN
cord-290677-3gdcyrrz	31	7	as	as	IN
cord-290677-3gdcyrrz	31	8	major	major	JJ
cord-290677-3gdcyrrz	31	9	producers	producer	NNS
cord-290677-3gdcyrrz	31	10	of	of	IN
cord-290677-3gdcyrrz	31	11	type	type	NN
cord-290677-3gdcyrrz	31	12	I	-PRON-	PRP
cord-290677-3gdcyrrz	31	13	interferons	interferon	NNS
cord-290677-3gdcyrrz	31	14	during	during	IN
cord-290677-3gdcyrrz	31	15	infection	infection	NN
cord-290677-3gdcyrrz	31	16	and	and	CC
cord-290677-3gdcyrrz	31	17	can	can	MD
cord-290677-3gdcyrrz	31	18	transport	transport	VB
cord-290677-3gdcyrrz	31	19	antigens	antigen	NNS
cord-290677-3gdcyrrz	31	20	from	from	IN
cord-290677-3gdcyrrz	31	21	the	the	DT
cord-290677-3gdcyrrz	31	22	infected	infected	JJ
cord-290677-3gdcyrrz	31	23	lung	lung	NN
cord-290677-3gdcyrrz	31	24	to	to	IN
cord-290677-3gdcyrrz	31	25	the	the	DT
cord-290677-3gdcyrrz	31	26	draining	drain	VBG
cord-290677-3gdcyrrz	31	27	lymph	lymph	NN
cord-290677-3gdcyrrz	31	28	nodes	node	NNS
cord-290677-3gdcyrrz	31	29	,	,	,
cord-290677-3gdcyrrz	31	30	where	where	WRB
cord-290677-3gdcyrrz	31	31	they	-PRON-	PRP
cord-290677-3gdcyrrz	31	32	serve	serve	VBP
cord-290677-3gdcyrrz	31	33	as	as	RB
cord-290677-3gdcyrrz	31	34	potent	potent	JJ
cord-290677-3gdcyrrz	31	35	APCs	apc	NNS
cord-290677-3gdcyrrz	31	36	for	for	IN
cord-290677-3gdcyrrz	31	37	the	the	DT
cord-290677-3gdcyrrz	31	38	induction	induction	NN
cord-290677-3gdcyrrz	31	39	of	of	IN
cord-290677-3gdcyrrz	31	40	virus	virus	NN
cord-290677-3gdcyrrz	31	41	-	-	HYPH
cord-290677-3gdcyrrz	31	42	specific	specific	JJ
cord-290677-3gdcyrrz	31	43	T	t	NN
cord-290677-3gdcyrrz	31	44	cells	cell	NNS
cord-290677-3gdcyrrz	31	45	22	22	CD
cord-290677-3gdcyrrz	31	46	,	,	,
cord-290677-3gdcyrrz	31	47	23	23	CD
cord-290677-3gdcyrrz	31	48	.	.	.
cord-290677-3gdcyrrz	32	1	Following	follow	VBG
cord-290677-3gdcyrrz	32	2	exposure	exposure	NN
cord-290677-3gdcyrrz	32	3	to	to	IN
cord-290677-3gdcyrrz	32	4	APCs	apc	NNS
cord-290677-3gdcyrrz	32	5	in	in	IN
cord-290677-3gdcyrrz	32	6	the	the	DT
cord-290677-3gdcyrrz	32	7	draining	drain	VBG
cord-290677-3gdcyrrz	32	8	lymph	lymph	NN
cord-290677-3gdcyrrz	32	9	nodes	node	NNS
cord-290677-3gdcyrrz	32	10	,	,	,
cord-290677-3gdcyrrz	32	11	virus	virus	NN
cord-290677-3gdcyrrz	32	12	-	-	HYPH
cord-290677-3gdcyrrz	32	13	specific	specific	JJ
cord-290677-3gdcyrrz	32	14	naive	naive	JJ
cord-290677-3gdcyrrz	32	15	T	t	NN
cord-290677-3gdcyrrz	32	16	cells	cell	NNS
cord-290677-3gdcyrrz	32	17	undergo	undergo	VBP
cord-290677-3gdcyrrz	32	18	a	a	DT
cord-290677-3gdcyrrz	32	19	stepwise	stepwise	JJ
cord-290677-3gdcyrrz	32	20	process	process	NN
cord-290677-3gdcyrrz	32	21	of	of	IN
cord-290677-3gdcyrrz	32	22	activation	activation	NN
cord-290677-3gdcyrrz	32	23	,	,	,
cord-290677-3gdcyrrz	32	24	proliferation	proliferation	NN
cord-290677-3gdcyrrz	32	25	and	and	CC
cord-290677-3gdcyrrz	32	26	differentiation	differentiation	NN
cord-290677-3gdcyrrz	32	27	to	to	TO
cord-290677-3gdcyrrz	32	28	become	become	VB
cord-290677-3gdcyrrz	32	29	effector	effector	JJ
cord-290677-3gdcyrrz	32	30	T	t	NN
cord-290677-3gdcyrrz	32	31	cells	cell	NNS
cord-290677-3gdcyrrz	32	32	,	,	,
cord-290677-3gdcyrrz	32	33	which	which	WDT
cord-290677-3gdcyrrz	32	34	can	can	MD
cord-290677-3gdcyrrz	32	35	migrate	migrate	VB
cord-290677-3gdcyrrz	32	36	to	to	IN
cord-290677-3gdcyrrz	32	37	the	the	DT
cord-290677-3gdcyrrz	32	38	site	site	NN
cord-290677-3gdcyrrz	32	39	of	of	IN
cord-290677-3gdcyrrz	32	40	infection	infection	NN
cord-290677-3gdcyrrz	32	41	and	and	CC
cord-290677-3gdcyrrz	32	42	mediate	mediate	VB
cord-290677-3gdcyrrz	32	43	antiviral	antiviral	JJ
cord-290677-3gdcyrrz	32	44	immune	immune	JJ
cord-290677-3gdcyrrz	32	45	responses	response	NNS
cord-290677-3gdcyrrz	32	46	.	.	.
cord-290677-3gdcyrrz	33	1	Virus	virus	NN
cord-290677-3gdcyrrz	33	2	-	-	HYPH
cord-290677-3gdcyrrz	33	3	specific	specific	JJ
cord-290677-3gdcyrrz	33	4	memory	memory	NN
cord-290677-3gdcyrrz	33	5	T	t	NN
cord-290677-3gdcyrrz	33	6	cells	cell	NNS
cord-290677-3gdcyrrz	33	7	are	be	VBP
cord-290677-3gdcyrrz	33	8	antigen	antigen	NN
cord-290677-3gdcyrrz	33	9	-	-	HYPH
cord-290677-3gdcyrrz	33	10	experienced	experience	VBN
cord-290677-3gdcyrrz	33	11	Importantly	importantly	RB
cord-290677-3gdcyrrz	33	12	,	,	,
cord-290677-3gdcyrrz	33	13	coronavirus	coronavirus	NN
cord-290677-3gdcyrrz	33	14	infections	infection	NNS
cord-290677-3gdcyrrz	33	15	are	be	VBP
cord-290677-3gdcyrrz	33	16	not	not	RB
cord-290677-3gdcyrrz	33	17	always	always	RB
cord-290677-3gdcyrrz	33	18	confined	confine	VBN
cord-290677-3gdcyrrz	33	19	to	to	IN
cord-290677-3gdcyrrz	33	20	the	the	DT
cord-290677-3gdcyrrz	33	21	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	33	22	tract	tract	NN
cord-290677-3gdcyrrz	33	23	,	,	,
cord-290677-3gdcyrrz	33	24	and	and	CC
cord-290677-3gdcyrrz	33	25	clinical	clinical	JJ
cord-290677-3gdcyrrz	33	26	studies	study	NNS
cord-290677-3gdcyrrz	33	27	have	have	VBP
cord-290677-3gdcyrrz	33	28	revealed	reveal	VBN
cord-290677-3gdcyrrz	33	29	a	a	DT
cord-290677-3gdcyrrz	33	30	degree	degree	NN
cord-290677-3gdcyrrz	33	31	of	of	IN
cord-290677-3gdcyrrz	33	32	symptomatic	symptomatic	JJ
cord-290677-3gdcyrrz	33	33	heterogeneity	heterogeneity	NN
cord-290677-3gdcyrrz	33	34	in	in	IN
cord-290677-3gdcyrrz	33	35	people	people	NNS
cord-290677-3gdcyrrz	33	36	with	with	IN
cord-290677-3gdcyrrz	33	37	COVID-19	COVID-19	NNP
cord-290677-3gdcyrrz	33	38	,	,	,
cord-290677-3gdcyrrz	33	39	with	with	IN
cord-290677-3gdcyrrz	33	40	anosmia	anosmia	NN
cord-290677-3gdcyrrz	33	41	being	be	VBG
cord-290677-3gdcyrrz	33	42	a	a	DT
cord-290677-3gdcyrrz	33	43	frequent	frequent	JJ
cord-290677-3gdcyrrz	33	44	occurrence	occurrence	NN
cord-290677-3gdcyrrz	33	45	3	3	CD
cord-290677-3gdcyrrz	33	46	and	and	CC
cord-290677-3gdcyrrz	33	47	severe	severe	JJ
cord-290677-3gdcyrrz	33	48	neurological	neurological	JJ
cord-290677-3gdcyrrz	33	49	symptoms	symptom	NNS
cord-290677-3gdcyrrz	33	50	being	be	VBG
cord-290677-3gdcyrrz	33	51	reported	report	VBN
cord-290677-3gdcyrrz	33	52	in	in	IN
cord-290677-3gdcyrrz	33	53	some	some	DT
cord-290677-3gdcyrrz	33	54	cases	case	NNS
cord-290677-3gdcyrrz	33	55	[	[	-LRB-
cord-290677-3gdcyrrz	33	56	4	4	CD
cord-290677-3gdcyrrz	33	57	]	]	-RRB-
cord-290677-3gdcyrrz	33	58	[	[	-LRB-
cord-290677-3gdcyrrz	33	59	5	5	CD
cord-290677-3gdcyrrz	33	60	]	]	-RRB-
cord-290677-3gdcyrrz	33	61	[	[	-LRB-
cord-290677-3gdcyrrz	33	62	6	6	CD
cord-290677-3gdcyrrz	33	63	]	]	-RRB-
cord-290677-3gdcyrrz	33	64	[	[	-LRB-
cord-290677-3gdcyrrz	33	65	7	7	CD
cord-290677-3gdcyrrz	33	66	]	]	-RRB-
cord-290677-3gdcyrrz	33	67	.	.	.
cord-290677-3gdcyrrz	34	1	These	these	DT
cord-290677-3gdcyrrz	34	2	observations	observation	NNS
cord-290677-3gdcyrrz	34	3	suggest	suggest	VBP
cord-290677-3gdcyrrz	34	4	that	that	IN
cord-290677-3gdcyrrz	34	5	a	a	DT
cord-290677-3gdcyrrz	34	6	range	range	NN
cord-290677-3gdcyrrz	34	7	of	of	IN
cord-290677-3gdcyrrz	34	8	different	different	JJ
cord-290677-3gdcyrrz	34	9	tissues	tissue	NNS
cord-290677-3gdcyrrz	34	10	and	and	CC
cord-290677-3gdcyrrz	34	11	cell	cell	NN
cord-290677-3gdcyrrz	34	12	types	type	NNS
cord-290677-3gdcyrrz	34	13	,	,	,
cord-290677-3gdcyrrz	34	14	including	include	VBG
cord-290677-3gdcyrrz	34	15	the	the	DT
cord-290677-3gdcyrrz	34	16	nervous	nervous	JJ
cord-290677-3gdcyrrz	34	17	system	system	NN
cord-290677-3gdcyrrz	34	18	3	3	CD
cord-290677-3gdcyrrz	34	19	,	,	,
cord-290677-3gdcyrrz	34	20	8	8	CD
cord-290677-3gdcyrrz	34	21	,	,	,
cord-290677-3gdcyrrz	34	22	are	be	VBP
cord-290677-3gdcyrrz	34	23	affected	affect	VBN
cord-290677-3gdcyrrz	34	24	by	by	IN
cord-290677-3gdcyrrz	34	25	the	the	DT
cord-290677-3gdcyrrz	34	26	virus	virus	NN
cord-290677-3gdcyrrz	34	27	.	.	.
cord-290677-3gdcyrrz	35	1	The	the	DT
cord-290677-3gdcyrrz	35	2	entry	entry	NN
cord-290677-3gdcyrrz	35	3	of	of	IN
cord-290677-3gdcyrrz	35	4	SARS	SARS	NNP
cord-290677-3gdcyrrz	35	5	-	-	HYPH
cord-290677-3gdcyrrz	35	6	CoV-2	CoV-2	NNP
cord-290677-3gdcyrrz	35	7	into	into	IN
cord-290677-3gdcyrrz	35	8	human	human	JJ
cord-290677-3gdcyrrz	35	9	host	host	NN
cord-290677-3gdcyrrz	35	10	cells	cell	NNS
cord-290677-3gdcyrrz	35	11	is	be	VBZ
cord-290677-3gdcyrrz	35	12	mediated	mediate	VBN
cord-290677-3gdcyrrz	35	13	mainly	mainly	RB
cord-290677-3gdcyrrz	35	14	by	by	IN
cord-290677-3gdcyrrz	35	15	the	the	DT
cord-290677-3gdcyrrz	35	16	transmembrane	transmembrane	NNP
cord-290677-3gdcyrrz	35	17	proteins	protein	NNS
cord-290677-3gdcyrrz	35	18	angiotensin	angiotensin	NN
cord-290677-3gdcyrrz	35	19	-	-	HYPH
cord-290677-3gdcyrrz	35	20	converting	convert	VBG
cord-290677-3gdcyrrz	35	21	enzyme	enzyme	NN
cord-290677-3gdcyrrz	35	22	2	2	CD
cord-290677-3gdcyrrz	35	23	(	(	-LRB-
cord-290677-3gdcyrrz	35	24	ACE2	ACE2	NNP
cord-290677-3gdcyrrz	35	25	)	)	-RRB-
cord-290677-3gdcyrrz	35	26	and	and	CC
cord-290677-3gdcyrrz	35	27	transmembrane	transmembrane	NN
cord-290677-3gdcyrrz	35	28	protease	protease	NN
cord-290677-3gdcyrrz	35	29	serine	serine	NN
cord-290677-3gdcyrrz	35	30	2	2	CD
cord-290677-3gdcyrrz	35	31	(	(	-LRB-
cord-290677-3gdcyrrz	35	32	TMPRSS2	TMPRSS2	NNP
cord-290677-3gdcyrrz	35	33	)	)	-RRB-
cord-290677-3gdcyrrz	35	34	,	,	,
cord-290677-3gdcyrrz	35	35	which	which	WDT
cord-290677-3gdcyrrz	35	36	are	be	VBP
cord-290677-3gdcyrrz	35	37	highly	highly	RB
cord-290677-3gdcyrrz	35	38	expressed	express	VBN
cord-290677-3gdcyrrz	35	39	in	in	IN
cord-290677-3gdcyrrz	35	40	the	the	DT
cord-290677-3gdcyrrz	35	41	airway	airway	NN
cord-290677-3gdcyrrz	35	42	epithelium	epithelium	NN
cord-290677-3gdcyrrz	35	43	,	,	,
cord-290677-3gdcyrrz	35	44	lung	lung	NN
cord-290677-3gdcyrrz	35	45	parenchyma	parenchyma	NN
cord-290677-3gdcyrrz	35	46	,	,	,
cord-290677-3gdcyrrz	35	47	vascular	vascular	JJ
cord-290677-3gdcyrrz	35	48	endothelium	endothelium	NN
cord-290677-3gdcyrrz	35	49	,	,	,
cord-290677-3gdcyrrz	35	50	heart	heart	NN
cord-290677-3gdcyrrz	35	51	,	,	,
cord-290677-3gdcyrrz	35	52	kidney	kidney	NN
cord-290677-3gdcyrrz	35	53	and	and	CC
cord-290677-3gdcyrrz	35	54	small	small	JJ
cord-290677-3gdcyrrz	35	55	intestine	intestine	NN
cord-290677-3gdcyrrz	35	56	in	in	IN
cord-290677-3gdcyrrz	35	57	humans	human	NNS
cord-290677-3gdcyrrz	35	58	[	[	-LRB-
cord-290677-3gdcyrrz	35	59	9	9	CD
cord-290677-3gdcyrrz	35	60	]	]	-RRB-
cord-290677-3gdcyrrz	35	61	[	[	-LRB-
cord-290677-3gdcyrrz	35	62	10	10	CD
cord-290677-3gdcyrrz	35	63	]	]	-RRB-
cord-290677-3gdcyrrz	35	64	[	[	-LRB-
cord-290677-3gdcyrrz	35	65	11	11	CD
cord-290677-3gdcyrrz	35	66	]	]	-RRB-
cord-290677-3gdcyrrz	35	67	.	.	.
cord-290677-3gdcyrrz	36	1	Most	most	RBS
cord-290677-3gdcyrrz	36	2	notably	notably	RB
cord-290677-3gdcyrrz	36	3	,	,	,
cord-290677-3gdcyrrz	36	4	both	both	CC
cord-290677-3gdcyrrz	36	5	ACE2	ACE2	NNP
cord-290677-3gdcyrrz	36	6	and	and	CC
cord-290677-3gdcyrrz	36	7	TMPRSS2	TMPRSS2	NNP
cord-290677-3gdcyrrz	36	8	are	be	VBP
cord-290677-3gdcyrrz	36	9	expressed	express	VBN
cord-290677-3gdcyrrz	36	10	in	in	IN
cord-290677-3gdcyrrz	36	11	the	the	DT
cord-290677-3gdcyrrz	36	12	olfactory	olfactory	JJ
cord-290677-3gdcyrrz	36	13	epithelium	epithelium	NN
cord-290677-3gdcyrrz	36	14	and	and	CC
cord-290677-3gdcyrrz	36	15	lower	low	JJR
cord-290677-3gdcyrrz	36	16	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	36	17	tract	tract	NN
cord-290677-3gdcyrrz	36	18	,	,	,
cord-290677-3gdcyrrz	36	19	which	which	WDT
cord-290677-3gdcyrrz	36	20	are	be	VBP
cord-290677-3gdcyrrz	36	21	densely	densely	RB
cord-290677-3gdcyrrz	36	22	innervated	innervate	VBN
cord-290677-3gdcyrrz	36	23	12	12	CD
cord-290677-3gdcyrrz	36	24	,	,	,
cord-290677-3gdcyrrz	36	25	13	13	CD
cord-290677-3gdcyrrz	36	26	.	.	.
cord-290677-3gdcyrrz	37	1	These	these	DT
cord-290677-3gdcyrrz	37	2	barrier	barrier	NN
cord-290677-3gdcyrrz	37	3	tissues	tissue	NNS
cord-290677-3gdcyrrz	37	4	are	be	VBP
cord-290677-3gdcyrrz	37	5	postulated	postulate	VBN
cord-290677-3gdcyrrz	37	6	to	to	TO
cord-290677-3gdcyrrz	37	7	be	be	VB
cord-290677-3gdcyrrz	37	8	key	key	JJ
cord-290677-3gdcyrrz	37	9	invasion	invasion	NN
cord-290677-3gdcyrrz	37	10	sites	site	NNS
cord-290677-3gdcyrrz	37	11	for	for	IN
cord-290677-3gdcyrrz	37	12	SARS	SARS	NNP
cord-290677-3gdcyrrz	37	13	-	-	HYPH
cord-290677-3gdcyrrz	37	14	CoV-2	CoV-2	NNP
cord-290677-3gdcyrrz	37	15	and	and	CC
cord-290677-3gdcyrrz	37	16	might	may	MD
cord-290677-3gdcyrrz	37	17	be	be	VB
cord-290677-3gdcyrrz	37	18	involved	involve	VBN
cord-290677-3gdcyrrz	37	19	in	in	IN
cord-290677-3gdcyrrz	37	20	nervous	nervous	JJ
cord-290677-3gdcyrrz	37	21	system	system	NN
cord-290677-3gdcyrrz	37	22	infection	infection	NN
cord-290677-3gdcyrrz	37	23	.	.	.
cord-290677-3gdcyrrz	38	1	ACE2	ACE2	NNP
cord-290677-3gdcyrrz	38	2	is	be	VBZ
cord-290677-3gdcyrrz	38	3	widely	widely	RB
cord-290677-3gdcyrrz	38	4	expressed	express	VBN
cord-290677-3gdcyrrz	38	5	throughout	throughout	IN
cord-290677-3gdcyrrz	38	6	the	the	DT
cord-290677-3gdcyrrz	38	7	nervous	nervous	JJ
cord-290677-3gdcyrrz	38	8	system	system	NN
cord-290677-3gdcyrrz	38	9	[	[	-LRB-
cord-290677-3gdcyrrz	38	10	14	14	CD
cord-290677-3gdcyrrz	38	11	]	]	-RRB-
cord-290677-3gdcyrrz	38	12	[	[	-LRB-
cord-290677-3gdcyrrz	38	13	15	15	CD
cord-290677-3gdcyrrz	38	14	]	]	-RRB-
cord-290677-3gdcyrrz	38	15	[	[	-LRB-
cord-290677-3gdcyrrz	38	16	16	16	CD
cord-290677-3gdcyrrz	38	17	]	]	-RRB-
cord-290677-3gdcyrrz	38	18	,	,	,
cord-290677-3gdcyrrz	38	19	making	make	VBG
cord-290677-3gdcyrrz	38	20	neural	neural	JJ
cord-290677-3gdcyrrz	38	21	cells	cell	NNS
cord-290677-3gdcyrrz	38	22	susceptible	susceptible	JJ
cord-290677-3gdcyrrz	38	23	cells	cell	NNS
cord-290677-3gdcyrrz	38	24	that	that	WDT
cord-290677-3gdcyrrz	38	25	have	have	VBP
cord-290677-3gdcyrrz	38	26	acquired	acquire	VBN
cord-290677-3gdcyrrz	38	27	the	the	DT
cord-290677-3gdcyrrz	38	28	capacity	capacity	NN
cord-290677-3gdcyrrz	38	29	to	to	TO
cord-290677-3gdcyrrz	38	30	rapidly	rapidly	RB
cord-290677-3gdcyrrz	38	31	implement	implement	VB
cord-290677-3gdcyrrz	38	32	effector	effector	NN
cord-290677-3gdcyrrz	38	33	functions	function	NNS
cord-290677-3gdcyrrz	38	34	and	and	CC
cord-290677-3gdcyrrz	38	35	exert	exert	VB
cord-290677-3gdcyrrz	38	36	antiviral	antiviral	JJ
cord-290677-3gdcyrrz	38	37	activity	activity	NN
cord-290677-3gdcyrrz	38	38	.	.	.
cord-290677-3gdcyrrz	39	1	Three	three	CD
cord-290677-3gdcyrrz	39	2	main	main	JJ
cord-290677-3gdcyrrz	39	3	antiviral	antiviral	JJ
cord-290677-3gdcyrrz	39	4	effector	effector	NN
cord-290677-3gdcyrrz	39	5	mechanisms	mechanism	NNS
cord-290677-3gdcyrrz	39	6	have	have	VBP
cord-290677-3gdcyrrz	39	7	been	be	VBN
cord-290677-3gdcyrrz	39	8	identified	identify	VBN
cord-290677-3gdcyrrz	39	9	:	:	:
cord-290677-3gdcyrrz	39	10	lysis	lysis	NN
cord-290677-3gdcyrrz	39	11	of	of	IN
cord-290677-3gdcyrrz	39	12	infected	infected	JJ
cord-290677-3gdcyrrz	39	13	cells	cell	NNS
cord-290677-3gdcyrrz	39	14	following	follow	VBG
cord-290677-3gdcyrrz	39	15	exocytosis	exocytosis	NN
cord-290677-3gdcyrrz	39	16	of	of	IN
cord-290677-3gdcyrrz	39	17	granules	granule	NNS
cord-290677-3gdcyrrz	39	18	containing	contain	VBG
cord-290677-3gdcyrrz	39	19	perforin	perforin	NNP
cord-290677-3gdcyrrz	39	20	and	and	CC
cord-290677-3gdcyrrz	39	21	granzyme	granzyme	NNS
cord-290677-3gdcyrrz	39	22	from	from	IN
cord-290677-3gdcyrrz	39	23	cytotoxic	cytotoxic	JJ
cord-290677-3gdcyrrz	39	24	T	t	NN
cord-290677-3gdcyrrz	39	25	cells	cell	NNS
cord-290677-3gdcyrrz	39	26	,	,	,
cord-290677-3gdcyrrz	39	27	possibly	possibly	RB
cord-290677-3gdcyrrz	39	28	with	with	IN
cord-290677-3gdcyrrz	39	29	the	the	DT
cord-290677-3gdcyrrz	39	30	cooperation	cooperation	NN
cord-290677-3gdcyrrz	39	31	of	of	IN
cord-290677-3gdcyrrz	39	32	B	b	NN
cord-290677-3gdcyrrz	39	33	cells	cell	NNS
cord-290677-3gdcyrrz	39	34	;	;	:
cord-290677-3gdcyrrz	39	35	tumour	tumour	NN
cord-290677-3gdcyrrz	39	36	necrosis	necrosis	NN
cord-290677-3gdcyrrz	39	37	factor	factor	NN
cord-290677-3gdcyrrz	39	38	(	(	-LRB-
cord-290677-3gdcyrrz	39	39	TNF	TNF	NNP
cord-290677-3gdcyrrz	39	40	)	)	-RRB-
cord-290677-3gdcyrrz	39	41	receptor	receptor	NN
cord-290677-3gdcyrrz	39	42	family	family	NN
cord-290677-3gdcyrrz	39	43	-	-	HYPH
cord-290677-3gdcyrrz	39	44	dependent	dependent	JJ
cord-290677-3gdcyrrz	39	45	apoptosis	apoptosis	NN
cord-290677-3gdcyrrz	39	46	of	of	IN
cord-290677-3gdcyrrz	39	47	infected	infected	JJ
cord-290677-3gdcyrrz	39	48	cells	cell	NNS
cord-290677-3gdcyrrz	39	49	and	and	CC
cord-290677-3gdcyrrz	39	50	phagocytosis	phagocytosis	NN
cord-290677-3gdcyrrz	39	51	following	follow	VBG
cord-290677-3gdcyrrz	39	52	recognition	recognition	NN
cord-290677-3gdcyrrz	39	53	of	of	IN
cord-290677-3gdcyrrz	39	54	these	these	DT
cord-290677-3gdcyrrz	39	55	cells	cell	NNS
cord-290677-3gdcyrrz	39	56	by	by	IN
cord-290677-3gdcyrrz	39	57	antibodies	antibody	NNS
cord-290677-3gdcyrrz	39	58	;	;	:
cord-290677-3gdcyrrz	39	59	and	and	CC
cord-290677-3gdcyrrz	39	60	production	production	NN
cord-290677-3gdcyrrz	39	61	of	of	IN
cord-290677-3gdcyrrz	39	62	pro	pro	JJ
cord-290677-3gdcyrrz	39	63	-	-	JJ
cord-290677-3gdcyrrz	39	64	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	39	65	mediators	mediator	NNS
cord-290677-3gdcyrrz	39	66	by	by	IN
cord-290677-3gdcyrrz	39	67	T	T	NNP
cord-290677-3gdcyrrz	39	68	cells	cell	NNS
cord-290677-3gdcyrrz	39	69	in	in	IN
cord-290677-3gdcyrrz	39	70	response	response	NN
cord-290677-3gdcyrrz	39	71	to	to	IN
cord-290677-3gdcyrrz	39	72	encountering	encounter	VBG
cord-290677-3gdcyrrz	39	73	virus	virus	NN
cord-290677-3gdcyrrz	39	74	-	-	HYPH
cord-290677-3gdcyrrz	39	75	infected	infect	VBN
cord-290677-3gdcyrrz	39	76	cells	cell	NNS
cord-290677-3gdcyrrz	39	77	.	.	.
cord-290677-3gdcyrrz	40	1	Immune	immune	JJ
cord-290677-3gdcyrrz	40	2	responses	response	NNS
cord-290677-3gdcyrrz	40	3	to	to	IN
cord-290677-3gdcyrrz	40	4	SARS	SARS	NNP
cord-290677-3gdcyrrz	40	5	-	-	HYPH
cord-290677-3gdcyrrz	40	6	CoV-2	CoV-2	NNP
cord-290677-3gdcyrrz	41	1	Clinically	clinically	RB
cord-290677-3gdcyrrz	41	2	,	,	,
cord-290677-3gdcyrrz	41	3	the	the	DT
cord-290677-3gdcyrrz	41	4	immune	immune	JJ
cord-290677-3gdcyrrz	41	5	responses	response	NNS
cord-290677-3gdcyrrz	41	6	induced	induce	VBN
cord-290677-3gdcyrrz	41	7	by	by	IN
cord-290677-3gdcyrrz	41	8	SARS	SARS	NNP
cord-290677-3gdcyrrz	41	9	-	-	HYPH
cord-290677-3gdcyrrz	41	10	CoV-2	CoV-2	NNP
cord-290677-3gdcyrrz	41	11	infection	infection	NN
cord-290677-3gdcyrrz	41	12	consist	consist	VBP
cord-290677-3gdcyrrz	41	13	of	of	IN
cord-290677-3gdcyrrz	41	14	two	two	CD
cord-290677-3gdcyrrz	41	15	phases	phase	NNS
cord-290677-3gdcyrrz	41	16	.	.	.
cord-290677-3gdcyrrz	42	1	During	during	IN
cord-290677-3gdcyrrz	42	2	the	the	DT
cord-290677-3gdcyrrz	42	3	initial	initial	JJ
cord-290677-3gdcyrrz	42	4	incubation	incubation	NN
cord-290677-3gdcyrrz	42	5	and	and	CC
cord-290677-3gdcyrrz	42	6	in	in	IN
cord-290677-3gdcyrrz	42	7	non	non	JJ
cord-290677-3gdcyrrz	42	8	-	-	JJ
cord-290677-3gdcyrrz	42	9	severe	severe	JJ
cord-290677-3gdcyrrz	42	10	stages	stage	NNS
cord-290677-3gdcyrrz	42	11	,	,	,
cord-290677-3gdcyrrz	42	12	a	a	DT
cord-290677-3gdcyrrz	42	13	specific	specific	JJ
cord-290677-3gdcyrrz	42	14	adaptive	adaptive	JJ
cord-290677-3gdcyrrz	42	15	immune	immune	JJ
cord-290677-3gdcyrrz	42	16	response	response	NN
cord-290677-3gdcyrrz	42	17	is	be	VBZ
cord-290677-3gdcyrrz	42	18	produced	produce	VBN
cord-290677-3gdcyrrz	42	19	to	to	TO
cord-290677-3gdcyrrz	42	20	eliminate	eliminate	VB
cord-290677-3gdcyrrz	42	21	the	the	DT
cord-290677-3gdcyrrz	42	22	virus	virus	NN
cord-290677-3gdcyrrz	42	23	and	and	CC
cord-290677-3gdcyrrz	42	24	abort	abort	VB
cord-290677-3gdcyrrz	42	25	disease	disease	NN
cord-290677-3gdcyrrz	42	26	progression	progression	NN
cord-290677-3gdcyrrz	42	27	.	.	.
cord-290677-3gdcyrrz	43	1	If	if	IN
cord-290677-3gdcyrrz	43	2	the	the	DT
cord-290677-3gdcyrrz	43	3	protective	protective	JJ
cord-290677-3gdcyrrz	43	4	immune	immune	JJ
cord-290677-3gdcyrrz	43	5	response	response	NN
cord-290677-3gdcyrrz	43	6	is	be	VBZ
cord-290677-3gdcyrrz	43	7	impaired	impair	VBN
cord-290677-3gdcyrrz	43	8	,	,	,
cord-290677-3gdcyrrz	43	9	the	the	DT
cord-290677-3gdcyrrz	43	10	virus	virus	NN
cord-290677-3gdcyrrz	43	11	is	be	VBZ
cord-290677-3gdcyrrz	43	12	allowed	allow	VBN
cord-290677-3gdcyrrz	43	13	to	to	TO
cord-290677-3gdcyrrz	43	14	replicate	replicate	VB
cord-290677-3gdcyrrz	43	15	and	and	CC
cord-290677-3gdcyrrz	43	16	can	can	MD
cord-290677-3gdcyrrz	43	17	cause	cause	VB
cord-290677-3gdcyrrz	43	18	widespread	widespread	JJ
cord-290677-3gdcyrrz	43	19	tissue	tissue	NN
cord-290677-3gdcyrrz	43	20	damage	damage	NN
cord-290677-3gdcyrrz	43	21	.	.	.
cord-290677-3gdcyrrz	44	1	The	the	DT
cord-290677-3gdcyrrz	44	2	lungs	lung	NNS
cord-290677-3gdcyrrz	44	3	seem	seem	VBP
cord-290677-3gdcyrrz	44	4	to	to	TO
cord-290677-3gdcyrrz	44	5	be	be	VB
cord-290677-3gdcyrrz	44	6	the	the	DT
cord-290677-3gdcyrrz	44	7	main	main	JJ
cord-290677-3gdcyrrz	44	8	target	target	NN
cord-290677-3gdcyrrz	44	9	,	,	,
cord-290677-3gdcyrrz	44	10	although	although	IN
cord-290677-3gdcyrrz	44	11	other	other	JJ
cord-290677-3gdcyrrz	44	12	organs	organ	NNS
cord-290677-3gdcyrrz	44	13	with	with	IN
cord-290677-3gdcyrrz	44	14	high	high	JJ
cord-290677-3gdcyrrz	44	15	ACE2	ACE2	NNP
cord-290677-3gdcyrrz	44	16	expression	expression	NN
cord-290677-3gdcyrrz	44	17	,	,	,
cord-290677-3gdcyrrz	44	18	such	such	JJ
cord-290677-3gdcyrrz	44	19	as	as	IN
cord-290677-3gdcyrrz	44	20	the	the	DT
cord-290677-3gdcyrrz	44	21	intestine	intestine	NN
cord-290677-3gdcyrrz	44	22	,	,	,
cord-290677-3gdcyrrz	44	23	heart	heart	NN
cord-290677-3gdcyrrz	44	24	,	,	,
cord-290677-3gdcyrrz	44	25	brain	brain	NN
cord-290677-3gdcyrrz	44	26	and	and	CC
cord-290677-3gdcyrrz	44	27	kidney	kidney	NN
cord-290677-3gdcyrrz	44	28	,	,	,
cord-290677-3gdcyrrz	44	29	might	may	MD
cord-290677-3gdcyrrz	44	30	also	also	RB
cord-290677-3gdcyrrz	44	31	be	be	VB
cord-290677-3gdcyrrz	44	32	vulnerable	vulnerable	JJ
cord-290677-3gdcyrrz	44	33	11	11	CD
cord-290677-3gdcyrrz	44	34	,	,	,
cord-290677-3gdcyrrz	44	35	24	24	CD
cord-290677-3gdcyrrz	44	36	.	.	.
cord-290677-3gdcyrrz	45	1	The	the	DT
cord-290677-3gdcyrrz	45	2	second	second	JJ
cord-290677-3gdcyrrz	45	3	phase	phase	NN
cord-290677-3gdcyrrz	45	4	is	be	VBZ
cord-290677-3gdcyrrz	45	5	usually	usually	RB
cord-290677-3gdcyrrz	45	6	associated	associate	VBN
cord-290677-3gdcyrrz	45	7	with	with	IN
cord-290677-3gdcyrrz	45	8	increased	increase	VBN
cord-290677-3gdcyrrz	45	9	severity	severity	NN
cord-290677-3gdcyrrz	45	10	of	of	IN
cord-290677-3gdcyrrz	45	11	the	the	DT
cord-290677-3gdcyrrz	45	12	disease	disease	NN
cord-290677-3gdcyrrz	45	13	and	and	CC
cord-290677-3gdcyrrz	45	14	is	be	VBZ
cord-290677-3gdcyrrz	45	15	characterized	characterize	VBN
cord-290677-3gdcyrrz	45	16	by	by	IN
cord-290677-3gdcyrrz	45	17	potentially	potentially	RB
cord-290677-3gdcyrrz	45	18	life	life	NN
cord-290677-3gdcyrrz	45	19	-	-	HYPH
cord-290677-3gdcyrrz	45	20	threatening	threaten	VBG
cord-290677-3gdcyrrz	45	21	lung	lung	NN
cord-290677-3gdcyrrz	45	22	inflammation	inflammation	NN
cord-290677-3gdcyrrz	45	23	25	25	CD
cord-290677-3gdcyrrz	45	24	and	and	CC
cord-290677-3gdcyrrz	45	25	the	the	DT
cord-290677-3gdcyrrz	45	26	appearance	appearance	NN
cord-290677-3gdcyrrz	45	27	of	of	IN
cord-290677-3gdcyrrz	45	28	systemic	systemic	JJ
cord-290677-3gdcyrrz	45	29	symptoms	symptom	NNS
cord-290677-3gdcyrrz	45	30	such	such	JJ
cord-290677-3gdcyrrz	45	31	as	as	IN
cord-290677-3gdcyrrz	45	32	high	high	JJ
cord-290677-3gdcyrrz	45	33	fever	fever	NN
cord-290677-3gdcyrrz	45	34	and	and	CC
cord-290677-3gdcyrrz	45	35	severe	severe	JJ
cord-290677-3gdcyrrz	45	36	muscle	muscle	NN
cord-290677-3gdcyrrz	45	37	pain	pain	NN
cord-290677-3gdcyrrz	45	38	.	.	.
cord-290677-3gdcyrrz	46	1	The	the	DT
cord-290677-3gdcyrrz	46	2	damaged	damage	VBN
cord-290677-3gdcyrrz	46	3	cells	cell	NNS
cord-290677-3gdcyrrz	46	4	in	in	IN
cord-290677-3gdcyrrz	46	5	the	the	DT
cord-290677-3gdcyrrz	46	6	lungs	lung	NNS
cord-290677-3gdcyrrz	46	7	elicit	elicit	VBP
cord-290677-3gdcyrrz	46	8	a	a	DT
cord-290677-3gdcyrrz	46	9	strong	strong	JJ
cord-290677-3gdcyrrz	46	10	innate	innate	JJ
cord-290677-3gdcyrrz	46	11	immune	immune	JJ
cord-290677-3gdcyrrz	46	12	response	response	NN
cord-290677-3gdcyrrz	46	13	,	,	,
cord-290677-3gdcyrrz	46	14	which	which	WDT
cord-290677-3gdcyrrz	46	15	seems	seem	VBZ
cord-290677-3gdcyrrz	46	16	to	to	TO
cord-290677-3gdcyrrz	46	17	be	be	VB
cord-290677-3gdcyrrz	46	18	largely	largely	RB
cord-290677-3gdcyrrz	46	19	mediated	mediate	VBN
cord-290677-3gdcyrrz	46	20	by	by	IN
cord-290677-3gdcyrrz	46	21	pro	pro	JJ
cord-290677-3gdcyrrz	46	22	-	-	JJ
cord-290677-3gdcyrrz	46	23	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	46	24	macrophages	macrophage	NNS
cord-290677-3gdcyrrz	46	25	and	and	CC
cord-290677-3gdcyrrz	46	26	granulocytes	granulocyte	NNS
cord-290677-3gdcyrrz	46	27	26	26	CD
cord-290677-3gdcyrrz	46	28	,	,	,
cord-290677-3gdcyrrz	46	29	27	27	CD
cord-290677-3gdcyrrz	46	30	.	.	.
cord-290677-3gdcyrrz	47	1	This	this	DT
cord-290677-3gdcyrrz	47	2	response	response	NN
cord-290677-3gdcyrrz	47	3	is	be	VBZ
cord-290677-3gdcyrrz	47	4	thought	think	VBN
cord-290677-3gdcyrrz	47	5	to	to	TO
cord-290677-3gdcyrrz	47	6	be	be	VB
cord-290677-3gdcyrrz	47	7	responsible	responsible	JJ
cord-290677-3gdcyrrz	47	8	for	for	IN
cord-290677-3gdcyrrz	47	9	the	the	DT
cord-290677-3gdcyrrz	47	10	cytokine	cytokine	NN
cord-290677-3gdcyrrz	47	11	release	release	NN
cord-290677-3gdcyrrz	47	12	syndrome	syndrome	NN
cord-290677-3gdcyrrz	47	13	or	or	CC
cord-290677-3gdcyrrz	47	14	'	'	``
cord-290677-3gdcyrrz	47	15	cytokine	cytokine	NN
cord-290677-3gdcyrrz	47	16	storm	storm	NN
cord-290677-3gdcyrrz	47	17	'	'	''
cord-290677-3gdcyrrz	47	18	that	that	WDT
cord-290677-3gdcyrrz	47	19	is	be	VBZ
cord-290677-3gdcyrrz	47	20	believed	believe	VBN
cord-290677-3gdcyrrz	47	21	to	to	TO
cord-290677-3gdcyrrz	47	22	contribute	contribute	VB
cord-290677-3gdcyrrz	47	23	to	to	IN
cord-290677-3gdcyrrz	47	24	ARDS	ARDS	NNP
cord-290677-3gdcyrrz	47	25	25	25	CD
cord-290677-3gdcyrrz	47	26	.	.	.
cord-290677-3gdcyrrz	48	1	The	the	DT
cord-290677-3gdcyrrz	48	2	idea	idea	NN
cord-290677-3gdcyrrz	48	3	that	that	IN
cord-290677-3gdcyrrz	48	4	the	the	DT
cord-290677-3gdcyrrz	48	5	cytokine	cytokine	NN
cord-290677-3gdcyrrz	48	6	storm	storm	NN
cord-290677-3gdcyrrz	48	7	is	be	VBZ
cord-290677-3gdcyrrz	48	8	mediated	mediate	VBN
cord-290677-3gdcyrrz	48	9	by	by	IN
cord-290677-3gdcyrrz	48	10	leukocytes	leukocyte	NNS
cord-290677-3gdcyrrz	48	11	other	other	JJ
cord-290677-3gdcyrrz	48	12	than	than	IN
cord-290677-3gdcyrrz	48	13	T	T	NNP
cord-290677-3gdcyrrz	48	14	or	or	CC
cord-290677-3gdcyrrz	48	15	B	B	NNP
cord-290677-3gdcyrrz	48	16	cells	cell	NNS
cord-290677-3gdcyrrz	48	17	is	be	VBZ
cord-290677-3gdcyrrz	48	18	supported	support	VBN
cord-290677-3gdcyrrz	48	19	by	by	IN
cord-290677-3gdcyrrz	48	20	observations	observation	NNS
cord-290677-3gdcyrrz	48	21	of	of	IN
cord-290677-3gdcyrrz	48	22	lymphocytopenia	lymphocytopenia	NNP
cord-290677-3gdcyrrz	48	23	and	and	CC
cord-290677-3gdcyrrz	48	24	sometimes	sometimes	RB
cord-290677-3gdcyrrz	48	25	atrophy	atrophy	NN
cord-290677-3gdcyrrz	48	26	of	of	IN
cord-290677-3gdcyrrz	48	27	the	the	DT
cord-290677-3gdcyrrz	48	28	lymphatic	lymphatic	JJ
cord-290677-3gdcyrrz	48	29	tissues	tissue	NNS
cord-290677-3gdcyrrz	48	30	,	,	,
cord-290677-3gdcyrrz	48	31	such	such	JJ
cord-290677-3gdcyrrz	48	32	as	as	IN
cord-290677-3gdcyrrz	48	33	lymph	lymph	NN
cord-290677-3gdcyrrz	48	34	nodes	node	NNS
cord-290677-3gdcyrrz	48	35	and	and	CC
cord-290677-3gdcyrrz	48	36	spleen	spleen	NNS
cord-290677-3gdcyrrz	48	37	,	,	,
cord-290677-3gdcyrrz	48	38	in	in	IN
cord-290677-3gdcyrrz	48	39	patients	patient	NNS
cord-290677-3gdcyrrz	48	40	with	with	IN
cord-290677-3gdcyrrz	48	41	severe	severe	JJ
cord-290677-3gdcyrrz	48	42	COVID-19	COVID-19	NNP
cord-290677-3gdcyrrz	48	43	(	(	-LRB-
cord-290677-3gdcyrrz	48	44	refs	ref	VBZ
cord-290677-3gdcyrrz	48	45	24,26,28	24,26,28	CD
cord-290677-3gdcyrrz	48	46	-	-	SYM
cord-290677-3gdcyrrz	48	47	30	30	CD
cord-290677-3gdcyrrz	48	48	)	)	-RRB-
cord-290677-3gdcyrrz	48	49	.	.	.
cord-290677-3gdcyrrz	49	1	In	in	IN
cord-290677-3gdcyrrz	49	2	line	line	NN
cord-290677-3gdcyrrz	49	3	with	with	IN
cord-290677-3gdcyrrz	49	4	observations	observation	NNS
cord-290677-3gdcyrrz	49	5	in	in	IN
cord-290677-3gdcyrrz	49	6	lethal	lethal	JJ
cord-290677-3gdcyrrz	49	7	cases	case	NNS
cord-290677-3gdcyrrz	49	8	of	of	IN
cord-290677-3gdcyrrz	49	9	SARS	SARS	NNP
cord-290677-3gdcyrrz	49	10	31	31	CD
cord-290677-3gdcyrrz	49	11	and	and	CC
cord-290677-3gdcyrrz	49	12	MERS	MERS	NNP
cord-290677-3gdcyrrz	49	13	32	32	CD
cord-290677-3gdcyrrz	49	14	,	,	,
cord-290677-3gdcyrrz	49	15	patients	patient	NNS
cord-290677-3gdcyrrz	49	16	infected	infect	VBN
cord-290677-3gdcyrrz	49	17	with	with	IN
cord-290677-3gdcyrrz	49	18	SARS	SARS	NNP
cord-290677-3gdcyrrz	49	19	-	-	HYPH
cord-290677-3gdcyrrz	49	20	CoV-2	CoV-2	NNP
cord-290677-3gdcyrrz	49	21	show	show	NN
cord-290677-3gdcyrrz	49	22	increased	increase	VBN
cord-290677-3gdcyrrz	49	23	numbers	number	NNS
cord-290677-3gdcyrrz	49	24	of	of	IN
cord-290677-3gdcyrrz	49	25	neutrophils	neutrophil	NNS
cord-290677-3gdcyrrz	49	26	and	and	CC
cord-290677-3gdcyrrz	49	27	macrophages	macrophage	NNS
cord-290677-3gdcyrrz	49	28	in	in	IN
cord-290677-3gdcyrrz	49	29	their	-PRON-	PRP$
cord-290677-3gdcyrrz	49	30	airways	airway	NNS
cord-290677-3gdcyrrz	49	31	and	and	CC
cord-290677-3gdcyrrz	49	32	blood	blood	NN
cord-290677-3gdcyrrz	49	33	28	28	CD
cord-290677-3gdcyrrz	49	34	,	,	,
cord-290677-3gdcyrrz	49	35	33	33	CD
cord-290677-3gdcyrrz	49	36	.	.	.
cord-290677-3gdcyrrz	50	1	Levels	level	NNS
cord-290677-3gdcyrrz	50	2	of	of	IN
cord-290677-3gdcyrrz	50	3	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	50	4	cytokines	cytokine	NNS
cord-290677-3gdcyrrz	50	5	such	such	JJ
cord-290677-3gdcyrrz	50	6	as	as	IN
cord-290677-3gdcyrrz	50	7	IL-1	IL-1	NNP
cord-290677-3gdcyrrz	50	8	,	,	,
cord-290677-3gdcyrrz	50	9	TNF	TNF	NNP
cord-290677-3gdcyrrz	50	10	and	and	CC
cord-290677-3gdcyrrz	50	11	IL-6	IL-6	NNP
cord-290677-3gdcyrrz	50	12	can	can	MD
cord-290677-3gdcyrrz	50	13	be	be	VB
cord-290677-3gdcyrrz	50	14	high	high	JJ
cord-290677-3gdcyrrz	50	15	in	in	IN
cord-290677-3gdcyrrz	50	16	the	the	DT
cord-290677-3gdcyrrz	50	17	lungs	lung	NNS
cord-290677-3gdcyrrz	50	18	of	of	IN
cord-290677-3gdcyrrz	50	19	patients	patient	NNS
cord-290677-3gdcyrrz	50	20	with	with	IN
cord-290677-3gdcyrrz	50	21	COVID-19	COVID-19	NNP
cord-290677-3gdcyrrz	50	22	(	(	-LRB-
cord-290677-3gdcyrrz	50	23	refs	refs	NNP
cord-290677-3gdcyrrz	50	24	1,34	1,34	CD
cord-290677-3gdcyrrz	50	25	)	)	-RRB-
cord-290677-3gdcyrrz	50	26	;	;	:
cord-290677-3gdcyrrz	50	27	therefore	therefore	RB
cord-290677-3gdcyrrz	50	28	,	,	,
cord-290677-3gdcyrrz	50	29	blocking	block	VBG
cord-290677-3gdcyrrz	50	30	one	one	CD
cord-290677-3gdcyrrz	50	31	or	or	CC
cord-290677-3gdcyrrz	50	32	more	more	JJR
cord-290677-3gdcyrrz	50	33	of	of	IN
cord-290677-3gdcyrrz	50	34	these	these	DT
cord-290677-3gdcyrrz	50	35	cytokines	cytokine	NNS
cord-290677-3gdcyrrz	50	36	could	could	MD
cord-290677-3gdcyrrz	50	37	potentially	potentially	RB
cord-290677-3gdcyrrz	50	38	benefit	benefit	VB
cord-290677-3gdcyrrz	50	39	these	these	DT
cord-290677-3gdcyrrz	50	40	individuals	individual	NNS
cord-290677-3gdcyrrz	50	41	by	by	IN
cord-290677-3gdcyrrz	50	42	reducing	reduce	VBG
cord-290677-3gdcyrrz	50	43	the	the	DT
cord-290677-3gdcyrrz	50	44	severity	severity	NN
cord-290677-3gdcyrrz	50	45	of	of	IN
cord-290677-3gdcyrrz	50	46	the	the	DT
cord-290677-3gdcyrrz	50	47	cytokine	cytokine	NN
cord-290677-3gdcyrrz	50	48	storm	storm	NN
cord-290677-3gdcyrrz	50	49	and	and	CC
cord-290677-3gdcyrrz	50	50	ARDS	ARDS	NNP
cord-290677-3gdcyrrz	50	51	.	.	.
cord-290677-3gdcyrrz	51	1	Initial	initial	JJ
cord-290677-3gdcyrrz	51	2	attempts	attempt	NNS
cord-290677-3gdcyrrz	51	3	to	to	TO
cord-290677-3gdcyrrz	51	4	improve	improve	VB
cord-290677-3gdcyrrz	51	5	COVID-19	covid-19	JJ
cord-290677-3gdcyrrz	51	6	outcomes	outcome	NNS
cord-290677-3gdcyrrz	51	7	by	by	IN
cord-290677-3gdcyrrz	51	8	blocking	block	VBG
cord-290677-3gdcyrrz	51	9	IL-6	IL-6	NNP
cord-290677-3gdcyrrz	51	10	have	have	VBP
cord-290677-3gdcyrrz	51	11	shown	show	VBN
cord-290677-3gdcyrrz	51	12	some	some	DT
cord-290677-3gdcyrrz	51	13	promise	promise	NN
cord-290677-3gdcyrrz	51	14	35	35	CD
cord-290677-3gdcyrrz	51	15	,	,	,
cord-290677-3gdcyrrz	51	16	although	although	IN
cord-290677-3gdcyrrz	51	17	the	the	DT
cord-290677-3gdcyrrz	51	18	complexity	complexity	NN
cord-290677-3gdcyrrz	51	19	of	of	IN
cord-290677-3gdcyrrz	51	20	the	the	DT
cord-290677-3gdcyrrz	51	21	immune	immune	JJ
cord-290677-3gdcyrrz	51	22	response	response	NN
cord-290677-3gdcyrrz	51	23	to	to	IN
cord-290677-3gdcyrrz	51	24	SARS	SARS	NNP
cord-290677-3gdcyrrz	51	25	-	-	HYPH
cord-290677-3gdcyrrz	51	26	CoV-2	CoV-2	NNP
cord-290677-3gdcyrrz	51	27	might	may	MD
cord-290677-3gdcyrrz	51	28	limit	limit	VB
cord-290677-3gdcyrrz	51	29	the	the	DT
cord-290677-3gdcyrrz	51	30	efficacy	efficacy	NN
cord-290677-3gdcyrrz	51	31	of	of	IN
cord-290677-3gdcyrrz	51	32	this	this	DT
cord-290677-3gdcyrrz	51	33	approach	approach	NN
cord-290677-3gdcyrrz	51	34	.	.	.
cord-290677-3gdcyrrz	52	1	A	a	DT
cord-290677-3gdcyrrz	52	2	recent	recent	JJ
cord-290677-3gdcyrrz	52	3	study	study	NN
cord-290677-3gdcyrrz	52	4	found	find	VBD
cord-290677-3gdcyrrz	52	5	that	that	IN
cord-290677-3gdcyrrz	52	6	in	in	IN
cord-290677-3gdcyrrz	52	7	individuals	individual	NNS
cord-290677-3gdcyrrz	52	8	with	with	IN
cord-290677-3gdcyrrz	52	9	severe	severe	JJ
cord-290677-3gdcyrrz	52	10	COVID-19	covid-19	JJ
cord-290677-3gdcyrrz	52	11	,	,	,
cord-290677-3gdcyrrz	52	12	plasma	plasma	NN
cord-290677-3gdcyrrz	52	13	levels	level	NNS
cord-290677-3gdcyrrz	52	14	of	of	IN
cord-290677-3gdcyrrz	52	15	IL-6	IL-6	NNP
cord-290677-3gdcyrrz	52	16	were	be	VBD
cord-290677-3gdcyrrz	52	17	generally	generally	RB
cord-290677-3gdcyrrz	52	18	above	above	IN
cord-290677-3gdcyrrz	52	19	the	the	DT
cord-290677-3gdcyrrz	52	20	normal	normal	JJ
cord-290677-3gdcyrrz	52	21	range	range	NN
cord-290677-3gdcyrrz	52	22	but	but	CC
cord-290677-3gdcyrrz	52	23	lower	low	JJR
cord-290677-3gdcyrrz	52	24	than	than	IN
cord-290677-3gdcyrrz	52	25	the	the	DT
cord-290677-3gdcyrrz	52	26	median	median	JJ
cord-290677-3gdcyrrz	52	27	values	value	NNS
cord-290677-3gdcyrrz	52	28	typically	typically	RB
cord-290677-3gdcyrrz	52	29	reported	report	VBN
cord-290677-3gdcyrrz	52	30	in	in	IN
cord-290677-3gdcyrrz	52	31	ARDS	ARDS	NNP
cord-290677-3gdcyrrz	52	32	36	36	CD
cord-290677-3gdcyrrz	52	33	,	,	,
cord-290677-3gdcyrrz	52	34	suggesting	suggest	VBG
cord-290677-3gdcyrrz	52	35	that	that	IN
cord-290677-3gdcyrrz	52	36	the	the	DT
cord-290677-3gdcyrrz	52	37	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	52	38	and	and	CC
cord-290677-3gdcyrrz	52	39	cytokine	cytokine	NN
cord-290677-3gdcyrrz	52	40	profiles	profile	NNS
cord-290677-3gdcyrrz	52	41	induced	induce	VBN
cord-290677-3gdcyrrz	52	42	by	by	IN
cord-290677-3gdcyrrz	52	43	SARS	SARS	NNP
cord-290677-3gdcyrrz	52	44	-	-	HYPH
cord-290677-3gdcyrrz	52	45	CoV-2	CoV-2	NNP
cord-290677-3gdcyrrz	52	46	infection	infection	NN
cord-290677-3gdcyrrz	52	47	are	be	VBP
cord-290677-3gdcyrrz	52	48	more	more	RBR
cord-290677-3gdcyrrz	52	49	complex	complex	JJ
cord-290677-3gdcyrrz	52	50	than	than	IN
cord-290677-3gdcyrrz	52	51	previously	previously	RB
cord-290677-3gdcyrrz	52	52	thought	think	VBN
cord-290677-3gdcyrrz	52	53	,	,	,
cord-290677-3gdcyrrz	52	54	and	and	CC
cord-290677-3gdcyrrz	52	55	that	that	IN
cord-290677-3gdcyrrz	52	56	the	the	DT
cord-290677-3gdcyrrz	52	57	role	role	NN
cord-290677-3gdcyrrz	52	58	of	of	IN
cord-290677-3gdcyrrz	52	59	cytokine	cytokine	NN
cord-290677-3gdcyrrz	52	60	dysregulation	dysregulation	NN
cord-290677-3gdcyrrz	52	61	following	follow	VBG
cord-290677-3gdcyrrz	52	62	SARS	SARS	NNP
cord-290677-3gdcyrrz	52	63	-	-	HYPH
cord-290677-3gdcyrrz	52	64	CoV-2	CoV-2	NNP
cord-290677-3gdcyrrz	52	65	infection	infection	NN
cord-290677-3gdcyrrz	52	66	requires	require	VBZ
cord-290677-3gdcyrrz	52	67	further	further	JJ
cord-290677-3gdcyrrz	52	68	clarification	clarification	NN
cord-290677-3gdcyrrz	52	69	.	.	.
cord-290677-3gdcyrrz	53	1	Elevated	elevated	JJ
cord-290677-3gdcyrrz	53	2	levels	level	NNS
cord-290677-3gdcyrrz	53	3	of	of	IN
cord-290677-3gdcyrrz	53	4	cytokines	cytokine	NNS
cord-290677-3gdcyrrz	53	5	might	may	MD
cord-290677-3gdcyrrz	53	6	have	have	VB
cord-290677-3gdcyrrz	53	7	an	an	DT
cord-290677-3gdcyrrz	53	8	impact	impact	NN
cord-290677-3gdcyrrz	53	9	on	on	IN
cord-290677-3gdcyrrz	53	10	lung	lung	NN
cord-290677-3gdcyrrz	53	11	function	function	NN
cord-290677-3gdcyrrz	53	12	even	even	RB
cord-290677-3gdcyrrz	53	13	when	when	WRB
cord-290677-3gdcyrrz	53	14	below	below	IN
cord-290677-3gdcyrrz	53	15	the	the	DT
cord-290677-3gdcyrrz	53	16	cytokine	cytokine	NN
cord-290677-3gdcyrrz	53	17	storm	storm	NN
cord-290677-3gdcyrrz	53	18	threshold	threshold	NN
cord-290677-3gdcyrrz	53	19	because	because	IN
cord-290677-3gdcyrrz	53	20	of	of	IN
cord-290677-3gdcyrrz	53	21	the	the	DT
cord-290677-3gdcyrrz	53	22	unique	unique	JJ
cord-290677-3gdcyrrz	53	23	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	53	24	profile	profile	NN
cord-290677-3gdcyrrz	53	25	associated	associate	VBN
cord-290677-3gdcyrrz	53	26	with	with	IN
cord-290677-3gdcyrrz	53	27	COVID-19	COVID-19	NNP
cord-290677-3gdcyrrz	53	28	.	.	.
cord-290677-3gdcyrrz	54	1	In	in	IN
cord-290677-3gdcyrrz	54	2	addition	addition	NN
cord-290677-3gdcyrrz	54	3	,	,	,
cord-290677-3gdcyrrz	54	4	levels	level	NNS
cord-290677-3gdcyrrz	54	5	of	of	IN
cord-290677-3gdcyrrz	54	6	specific	specific	JJ
cord-290677-3gdcyrrz	54	7	cytokines	cytokine	NNS
cord-290677-3gdcyrrz	54	8	might	may	MD
cord-290677-3gdcyrrz	54	9	be	be	VB
cord-290677-3gdcyrrz	54	10	elevated	elevate	VBN
cord-290677-3gdcyrrz	54	11	predominantly	predominantly	RB
cord-290677-3gdcyrrz	54	12	in	in	IN
cord-290677-3gdcyrrz	54	13	the	the	DT
cord-290677-3gdcyrrz	54	14	lung	lung	NN
cord-290677-3gdcyrrz	54	15	alveolar	alveolar	NN
cord-290677-3gdcyrrz	54	16	microenvironment	microenvironment	NN
cord-290677-3gdcyrrz	54	17	,	,	,
cord-290677-3gdcyrrz	54	18	contributing	contribute	VBG
cord-290677-3gdcyrrz	54	19	to	to	IN
cord-290677-3gdcyrrz	54	20	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	54	21	distress	distress	NN
cord-290677-3gdcyrrz	54	22	.	.	.
cord-290677-3gdcyrrz	55	1	Interestingly	interestingly	RB
cord-290677-3gdcyrrz	55	2	,	,	,
cord-290677-3gdcyrrz	55	3	with	with	IN
cord-290677-3gdcyrrz	55	4	age	age	NN
cord-290677-3gdcyrrz	55	5	,	,	,
cord-290677-3gdcyrrz	55	6	macrophage	macrophage	NN
cord-290677-3gdcyrrz	55	7	activity	activity	NN
cord-290677-3gdcyrrz	55	8	declines	decline	VBZ
cord-290677-3gdcyrrz	55	9	and	and	CC
cord-290677-3gdcyrrz	55	10	pro	pro	JJ
cord-290677-3gdcyrrz	55	11	-	-	JJ
cord-290677-3gdcyrrz	55	12	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	55	13	cytokine	cytokine	NN
cord-290677-3gdcyrrz	55	14	levels	level	NNS
cord-290677-3gdcyrrz	55	15	increase	increase	VBP
cord-290677-3gdcyrrz	55	16	37	37	CD
cord-290677-3gdcyrrz	55	17	;	;	:
cord-290677-3gdcyrrz	55	18	moreover	moreover	RB
cord-290677-3gdcyrrz	55	19	,	,	,
cord-290677-3gdcyrrz	55	20	naive	naive	JJ
cord-290677-3gdcyrrz	55	21	T	t	NN
cord-290677-3gdcyrrz	55	22	cell	cell	NN
cord-290677-3gdcyrrz	55	23	production	production	NN
cord-290677-3gdcyrrz	55	24	and	and	CC
cord-290677-3gdcyrrz	55	25	effector	effector	NN
cord-290677-3gdcyrrz	55	26	memory	memory	NN
cord-290677-3gdcyrrz	55	27	T	T	NNP
cord-290677-3gdcyrrz	55	28	cell	cell	NN
cord-290677-3gdcyrrz	55	29	competency	competency	NN
cord-290677-3gdcyrrz	55	30	decline	decline	NN
cord-290677-3gdcyrrz	55	31	38	38	CD
cord-290677-3gdcyrrz	55	32	,	,	,
cord-290677-3gdcyrrz	55	33	39	39	CD
cord-290677-3gdcyrrz	55	34	.	.	.
cord-290677-3gdcyrrz	56	1	Together	together	RB
cord-290677-3gdcyrrz	56	2	,	,	,
cord-290677-3gdcyrrz	56	3	these	these	DT
cord-290677-3gdcyrrz	56	4	phenomena	phenomenon	NNS
cord-290677-3gdcyrrz	56	5	could	could	MD
cord-290677-3gdcyrrz	56	6	contribute	contribute	VB
cord-290677-3gdcyrrz	56	7	to	to	IN
cord-290677-3gdcyrrz	56	8	worsening	worsen	VBG
cord-290677-3gdcyrrz	56	9	of	of	IN
cord-290677-3gdcyrrz	56	10	the	the	DT
cord-290677-3gdcyrrz	56	11	severity	severity	NN
cord-290677-3gdcyrrz	56	12	and	and	CC
cord-290677-3gdcyrrz	56	13	outcomes	outcome	NNS
cord-290677-3gdcyrrz	56	14	of	of	IN
cord-290677-3gdcyrrz	56	15	SARS	SARS	NNP
cord-290677-3gdcyrrz	56	16	-	-	HYPH
cord-290677-3gdcyrrz	56	17	CoV-2	CoV-2	NNP
cord-290677-3gdcyrrz	56	18	infection	infection	NN
cord-290677-3gdcyrrz	56	19	in	in	IN
cord-290677-3gdcyrrz	56	20	older	old	JJR
cord-290677-3gdcyrrz	56	21	individuals	individual	NNS
cord-290677-3gdcyrrz	56	22	,	,	,
cord-290677-3gdcyrrz	56	23	as	as	IN
cord-290677-3gdcyrrz	56	24	discussed	discuss	VBN
cord-290677-3gdcyrrz	56	25	in	in	IN
cord-290677-3gdcyrrz	56	26	more	more	JJR
cord-290677-3gdcyrrz	56	27	detail	detail	NN
cord-290677-3gdcyrrz	56	28	below	below	RB
cord-290677-3gdcyrrz	56	29	.	.	.
cord-290677-3gdcyrrz	57	1	The	the	DT
cord-290677-3gdcyrrz	57	2	possible	possible	JJ
cord-290677-3gdcyrrz	57	3	role	role	NN
cord-290677-3gdcyrrz	57	4	of	of	IN
cord-290677-3gdcyrrz	57	5	lung	lung	NN
cord-290677-3gdcyrrz	57	6	innervation	innervation	NN
cord-290677-3gdcyrrz	57	7	in	in	IN
cord-290677-3gdcyrrz	57	8	the	the	DT
cord-290677-3gdcyrrz	57	9	regulation	regulation	NN
cord-290677-3gdcyrrz	57	10	of	of	IN
cord-290677-3gdcyrrz	57	11	the	the	DT
cord-290677-3gdcyrrz	57	12	immune	immune	JJ
cord-290677-3gdcyrrz	57	13	response	response	NN
cord-290677-3gdcyrrz	57	14	to	to	IN
cord-290677-3gdcyrrz	57	15	SARS	SARS	NNP
cord-290677-3gdcyrrz	57	16	-	-	HYPH
cord-290677-3gdcyrrz	57	17	CoV-2	CoV-2	NNP
cord-290677-3gdcyrrz	57	18	is	be	VBZ
cord-290677-3gdcyrrz	57	19	an	an	DT
cord-290677-3gdcyrrz	57	20	important	important	JJ
cord-290677-3gdcyrrz	57	21	area	area	NN
cord-290677-3gdcyrrz	57	22	of	of	IN
cord-290677-3gdcyrrz	57	23	investigation	investigation	NN
cord-290677-3gdcyrrz	57	24	.	.	.
cord-290677-3gdcyrrz	58	1	The	the	DT
cord-290677-3gdcyrrz	58	2	lungs	lung	NNS
cord-290677-3gdcyrrz	58	3	are	be	VBP
cord-290677-3gdcyrrz	58	4	highly	highly	RB
cord-290677-3gdcyrrz	58	5	innervated	innervate	VBN
cord-290677-3gdcyrrz	58	6	,	,	,
cord-290677-3gdcyrrz	58	7	receiving	receive	VBG
cord-290677-3gdcyrrz	58	8	sensory	sensory	JJ
cord-290677-3gdcyrrz	58	9	,	,	,
cord-290677-3gdcyrrz	58	10	sympathetic	sympathetic	JJ
cord-290677-3gdcyrrz	58	11	and	and	CC
cord-290677-3gdcyrrz	58	12	parasympathetic	parasympathetic	JJ
cord-290677-3gdcyrrz	58	13	fibres	fibre	NNS
cord-290677-3gdcyrrz	58	14	(	(	-LRB-
cord-290677-3gdcyrrz	58	15	fig	fig	NN
cord-290677-3gdcyrrz	58	16	.	.	NNP
cord-290677-3gdcyrrz	58	17	1	1	CD
cord-290677-3gdcyrrz	58	18	)	)	-RRB-
cord-290677-3gdcyrrz	58	19	.	.	.
cord-290677-3gdcyrrz	59	1	Sympathetic	sympathetic	JJ
cord-290677-3gdcyrrz	59	2	innervation	innervation	NN
cord-290677-3gdcyrrz	59	3	of	of	IN
cord-290677-3gdcyrrz	59	4	the	the	DT
cord-290677-3gdcyrrz	59	5	lungs	lung	NNS
cord-290677-3gdcyrrz	59	6	originates	originate	VBZ
cord-290677-3gdcyrrz	59	7	from	from	IN
cord-290677-3gdcyrrz	59	8	sympathetic	sympathetic	JJ
cord-290677-3gdcyrrz	59	9	ganglia	ganglion	NNS
cord-290677-3gdcyrrz	59	10	that	that	WDT
cord-290677-3gdcyrrz	59	11	arise	arise	VBP
cord-290677-3gdcyrrz	59	12	from	from	IN
cord-290677-3gdcyrrz	59	13	the	the	DT
cord-290677-3gdcyrrz	59	14	upper	upper	JJ
cord-290677-3gdcyrrz	59	15	thoracic	thoracic	JJ
cord-290677-3gdcyrrz	59	16	segments	segment	NNS
cord-290677-3gdcyrrz	59	17	of	of	IN
cord-290677-3gdcyrrz	59	18	the	the	DT
cord-290677-3gdcyrrz	59	19	spinal	spinal	JJ
cord-290677-3gdcyrrz	59	20	cord	cord	NN
cord-290677-3gdcyrrz	59	21	and	and	CC
cord-290677-3gdcyrrz	59	22	provide	provide	VB
cord-290677-3gdcyrrz	59	23	noradrenergic	noradrenergic	JJ
cord-290677-3gdcyrrz	59	24	innervation	innervation	NN
cord-290677-3gdcyrrz	59	25	to	to	IN
cord-290677-3gdcyrrz	59	26	bronchial	bronchial	JJ
cord-290677-3gdcyrrz	59	27	blood	blood	NN
cord-290677-3gdcyrrz	59	28	vessels	vessel	NNS
cord-290677-3gdcyrrz	59	29	and	and	CC
cord-290677-3gdcyrrz	59	30	submucosal	submucosal	NN
cord-290677-3gdcyrrz	59	31	glands	gland	NNS
cord-290677-3gdcyrrz	59	32	.	.	.
cord-290677-3gdcyrrz	60	1	The	the	DT
cord-290677-3gdcyrrz	60	2	tenth	tenth	JJ
cord-290677-3gdcyrrz	60	3	cranial	cranial	JJ
cord-290677-3gdcyrrz	60	4	nerve	nerve	NN
cord-290677-3gdcyrrz	60	5	,	,	,
cord-290677-3gdcyrrz	60	6	or	or	CC
cord-290677-3gdcyrrz	60	7	vagus	vagus	NN
cord-290677-3gdcyrrz	60	8	nerve	nerve	NN
cord-290677-3gdcyrrz	60	9	,	,	,
cord-290677-3gdcyrrz	60	10	supplies	supply	VBZ
cord-290677-3gdcyrrz	60	11	all	all	DT
cord-290677-3gdcyrrz	60	12	parasympathetic	parasympathetic	JJ
cord-290677-3gdcyrrz	60	13	and	and	CC
cord-290677-3gdcyrrz	60	14	most	most	JJS
cord-290677-3gdcyrrz	60	15	of	of	IN
cord-290677-3gdcyrrz	60	16	the	the	DT
cord-290677-3gdcyrrz	60	17	sensory	sensory	JJ
cord-290677-3gdcyrrz	60	18	nerve	nerve	NN
cord-290677-3gdcyrrz	60	19	fibres	fibre	NNS
cord-290677-3gdcyrrz	60	20	to	to	IN
cord-290677-3gdcyrrz	60	21	the	the	DT
cord-290677-3gdcyrrz	60	22	airways	airway	NNS
cord-290677-3gdcyrrz	60	23	,	,	,
cord-290677-3gdcyrrz	60	24	although	although	IN
cord-290677-3gdcyrrz	60	25	some	some	DT
cord-290677-3gdcyrrz	60	26	more	more	RBR
cord-290677-3gdcyrrz	60	27	minor	minor	JJ
cord-290677-3gdcyrrz	60	28	sensory	sensory	JJ
cord-290677-3gdcyrrz	60	29	innervation	innervation	NN
cord-290677-3gdcyrrz	60	30	originates	originate	VBZ
cord-290677-3gdcyrrz	60	31	from	from	IN
cord-290677-3gdcyrrz	60	32	the	the	DT
cord-290677-3gdcyrrz	60	33	T1-T6	T1-T6	NNP
cord-290677-3gdcyrrz	60	34	dorsal	dorsal	JJ
cord-290677-3gdcyrrz	60	35	root	root	NN
cord-290677-3gdcyrrz	60	36	ganglia	ganglion	NNS
cord-290677-3gdcyrrz	60	37	.	.	.
cord-290677-3gdcyrrz	61	1	The	the	DT
cord-290677-3gdcyrrz	61	2	vagus	vagus	NN
cord-290677-3gdcyrrz	61	3	nerve	nerve	NN
cord-290677-3gdcyrrz	61	4	divides	divide	VBZ
cord-290677-3gdcyrrz	61	5	into	into	IN
cord-290677-3gdcyrrz	61	6	the	the	DT
cord-290677-3gdcyrrz	61	7	superior	superior	JJ
cord-290677-3gdcyrrz	61	8	laryngeal	laryngeal	NN
cord-290677-3gdcyrrz	61	9	and	and	CC
cord-290677-3gdcyrrz	61	10	recurrent	recurrent	JJ
cord-290677-3gdcyrrz	61	11	laryngeal	laryngeal	NN
cord-290677-3gdcyrrz	61	12	nerves	nerve	NNS
cord-290677-3gdcyrrz	61	13	,	,	,
cord-290677-3gdcyrrz	61	14	which	which	WDT
cord-290677-3gdcyrrz	61	15	carry	carry	VBP
cord-290677-3gdcyrrz	61	16	sensory	sensory	JJ
cord-290677-3gdcyrrz	61	17	fibres	fibre	NNS
cord-290677-3gdcyrrz	61	18	originating	originate	VBG
cord-290677-3gdcyrrz	61	19	in	in	IN
cord-290677-3gdcyrrz	61	20	the	the	DT
cord-290677-3gdcyrrz	61	21	jugular	jugular	NN
cord-290677-3gdcyrrz	61	22	and	and	CC
cord-290677-3gdcyrrz	61	23	nodose	nodose	JJ
cord-290677-3gdcyrrz	61	24	ganglia	ganglion	NNS
cord-290677-3gdcyrrz	61	25	and	and	CC
cord-290677-3gdcyrrz	61	26	parasympathetic	parasympathetic	JJ
cord-290677-3gdcyrrz	61	27	cholinergic	cholinergic	JJ
cord-290677-3gdcyrrz	61	28	fibres	fibre	NNS
cord-290677-3gdcyrrz	61	29	originating	originate	VBG
cord-290677-3gdcyrrz	61	30	in	in	IN
cord-290677-3gdcyrrz	61	31	the	the	DT
cord-290677-3gdcyrrz	61	32	petrosal	petrosal	NN
cord-290677-3gdcyrrz	61	33	ganglion	ganglion	NN
cord-290677-3gdcyrrz	61	34	to	to	IN
cord-290677-3gdcyrrz	61	35	the	the	DT
cord-290677-3gdcyrrz	61	36	trachea	trachea	NN
cord-290677-3gdcyrrz	61	37	and	and	CC
cord-290677-3gdcyrrz	61	38	main	main	JJ
cord-290677-3gdcyrrz	61	39	bronchi	bronchi	NN
cord-290677-3gdcyrrz	61	40	.	.	.
cord-290677-3gdcyrrz	62	1	Smaller	small	JJR
cord-290677-3gdcyrrz	62	2	branches	branch	NNS
cord-290677-3gdcyrrz	62	3	of	of	IN
cord-290677-3gdcyrrz	62	4	the	the	DT
cord-290677-3gdcyrrz	62	5	vagus	vagus	NN
cord-290677-3gdcyrrz	62	6	nerve	nerve	NN
cord-290677-3gdcyrrz	62	7	innervate	innervate	VBP
cord-290677-3gdcyrrz	62	8	the	the	DT
cord-290677-3gdcyrrz	62	9	rest	rest	NN
cord-290677-3gdcyrrz	62	10	of	of	IN
cord-290677-3gdcyrrz	62	11	the	the	DT
cord-290677-3gdcyrrz	62	12	lower	low	JJR
cord-290677-3gdcyrrz	62	13	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	62	14	tract	tract	NN
cord-290677-3gdcyrrz	62	15	40	40	CD
cord-290677-3gdcyrrz	62	16	,	,	,
cord-290677-3gdcyrrz	62	17	41	41	CD
cord-290677-3gdcyrrz	62	18	.	.	.
cord-290677-3gdcyrrz	63	1	Stimulation	stimulation	NN
cord-290677-3gdcyrrz	63	2	of	of	IN
cord-290677-3gdcyrrz	63	3	parasympathetic	parasympathetic	JJ
cord-290677-3gdcyrrz	63	4	pathways	pathway	NNS
cord-290677-3gdcyrrz	63	5	induces	induce	VBZ
cord-290677-3gdcyrrz	63	6	bronchoconstriction	bronchoconstriction	VBP
cord-290677-3gdcyrrz	63	7	,	,	,
cord-290677-3gdcyrrz	63	8	mucus	mucus	NN
cord-290677-3gdcyrrz	63	9	secretion	secretion	NN
cord-290677-3gdcyrrz	63	10	and	and	CC
cord-290677-3gdcyrrz	63	11	bronchial	bronchial	JJ
cord-290677-3gdcyrrz	63	12	vasodilation	vasodilation	NN
cord-290677-3gdcyrrz	63	13	,	,	,
cord-290677-3gdcyrrz	63	14	mediated	mediate	VBN
cord-290677-3gdcyrrz	63	15	by	by	IN
cord-290677-3gdcyrrz	63	16	muscarinic	muscarinic	JJ
cord-290677-3gdcyrrz	63	17	M3	M3	NNP
cord-290677-3gdcyrrz	63	18	receptors	receptor	NNS
cord-290677-3gdcyrrz	63	19	42	42	CD
cord-290677-3gdcyrrz	63	20	,	,	,
cord-290677-3gdcyrrz	63	21	43	43	CD
cord-290677-3gdcyrrz	63	22	.	.	.
cord-290677-3gdcyrrz	64	1	Muscarinic	Muscarinic	NNP
cord-290677-3gdcyrrz	64	2	M2	M2	NNP
cord-290677-3gdcyrrz	64	3	receptors	receptor	NNS
cord-290677-3gdcyrrz	64	4	are	be	VBP
cord-290677-3gdcyrrz	64	5	present	present	JJ
cord-290677-3gdcyrrz	64	6	on	on	IN
cord-290677-3gdcyrrz	64	7	presynaptic	presynaptic	JJ
cord-290677-3gdcyrrz	64	8	cholinergic	cholinergic	JJ
cord-290677-3gdcyrrz	64	9	nerve	nerve	NN
cord-290677-3gdcyrrz	64	10	terminals	terminal	NNS
cord-290677-3gdcyrrz	64	11	44	44	CD
cord-290677-3gdcyrrz	64	12	,	,	,
cord-290677-3gdcyrrz	64	13	and	and	CC
cord-290677-3gdcyrrz	64	14	activation	activation	NN
cord-290677-3gdcyrrz	64	15	of	of	IN
cord-290677-3gdcyrrz	64	16	these	these	DT
cord-290677-3gdcyrrz	64	17	receptors	receptor	NNS
cord-290677-3gdcyrrz	64	18	inhibits	inhibit	VBZ
cord-290677-3gdcyrrz	64	19	acetylcholine	acetylcholine	NN
cord-290677-3gdcyrrz	64	20	release	release	NN
cord-290677-3gdcyrrz	64	21	and	and	CC
cord-290677-3gdcyrrz	64	22	might	may	MD
cord-290677-3gdcyrrz	64	23	serve	serve	VB
cord-290677-3gdcyrrz	64	24	to	to	TO
cord-290677-3gdcyrrz	64	25	limit	limit	VB
cord-290677-3gdcyrrz	64	26	cholinergic	cholinergic	JJ
cord-290677-3gdcyrrz	64	27	bronchoconstriction	bronchoconstriction	NN
cord-290677-3gdcyrrz	64	28	.	.	.
cord-290677-3gdcyrrz	65	1	Interestingly	interestingly	RB
cord-290677-3gdcyrrz	65	2	,	,	,
cord-290677-3gdcyrrz	65	3	parainfluenza	parainfluenza	NNP
cord-290677-3gdcyrrz	65	4	virus	virus	NN
cord-290677-3gdcyrrz	65	5	has	have	VBZ
cord-290677-3gdcyrrz	65	6	been	be	VBN
cord-290677-3gdcyrrz	65	7	shown	show	VBN
cord-290677-3gdcyrrz	65	8	to	to	TO
cord-290677-3gdcyrrz	65	9	decrease	decrease	VB
cord-290677-3gdcyrrz	65	10	M2	M2	NNP
cord-290677-3gdcyrrz	65	11	muscarinic	muscarinic	JJ
cord-290677-3gdcyrrz	65	12	receptor	receptor	NN
cord-290677-3gdcyrrz	65	13	function	function	NN
cord-290677-3gdcyrrz	65	14	on	on	IN
cord-290677-3gdcyrrz	65	15	parasympathetic	parasympathetic	JJ
cord-290677-3gdcyrrz	65	16	nerves	nerve	NNS
cord-290677-3gdcyrrz	65	17	45	45	CD
cord-290677-3gdcyrrz	65	18	,	,	,
cord-290677-3gdcyrrz	65	19	and	and	CC
cord-290677-3gdcyrrz	65	20	loss	loss	NN
cord-290677-3gdcyrrz	65	21	of	of	IN
cord-290677-3gdcyrrz	65	22	M2	m2	JJ
cord-290677-3gdcyrrz	65	23	receptor	receptor	NN
cord-290677-3gdcyrrz	65	24	-	-	HYPH
cord-290677-3gdcyrrz	65	25	dependent	dependent	JJ
cord-290677-3gdcyrrz	65	26	negative	negative	JJ
cord-290677-3gdcyrrz	65	27	feedback	feedback	NN
cord-290677-3gdcyrrz	65	28	increases	increase	VBZ
cord-290677-3gdcyrrz	65	29	acetylcholine	acetylcholine	NN
cord-290677-3gdcyrrz	65	30	release	release	NN
cord-290677-3gdcyrrz	65	31	onto	onto	IN
cord-290677-3gdcyrrz	65	32	airway	airway	JJ
cord-290677-3gdcyrrz	65	33	smooth	smooth	JJ
cord-290677-3gdcyrrz	65	34	muscle	muscle	NN
cord-290677-3gdcyrrz	65	35	46	46	CD
cord-290677-3gdcyrrz	65	36	.	.	.
cord-290677-3gdcyrrz	66	1	Expression	expression	NN
cord-290677-3gdcyrrz	66	2	of	of	IN
cord-290677-3gdcyrrz	66	3	M2	M2	NNP
cord-290677-3gdcyrrz	66	4	and	and	CC
cord-290677-3gdcyrrz	66	5	M3	M3	NNP
cord-290677-3gdcyrrz	66	6	receptors	receptor	NNS
cord-290677-3gdcyrrz	66	7	by	by	IN
cord-290677-3gdcyrrz	66	8	lung	lung	NN
cord-290677-3gdcyrrz	66	9	macrophages	macrophage	NNS
cord-290677-3gdcyrrz	66	10	has	have	VBZ
cord-290677-3gdcyrrz	66	11	been	be	VBN
cord-290677-3gdcyrrz	66	12	described	describe	VBN
cord-290677-3gdcyrrz	66	13	47	47	CD
cord-290677-3gdcyrrz	66	14	,	,	,
cord-290677-3gdcyrrz	66	15	suggesting	suggest	VBG
cord-290677-3gdcyrrz	66	16	that	that	IN
cord-290677-3gdcyrrz	66	17	acetylcholine	acetylcholine	NN
cord-290677-3gdcyrrz	66	18	could	could	MD
cord-290677-3gdcyrrz	66	19	directly	directly	RB
cord-290677-3gdcyrrz	66	20	influence	influence	VB
cord-290677-3gdcyrrz	66	21	lung	lung	NN
cord-290677-3gdcyrrz	66	22	macrophage	macrophage	NN
cord-290677-3gdcyrrz	66	23	activity	activity	NN
cord-290677-3gdcyrrz	66	24	and	and	CC
cord-290677-3gdcyrrz	66	25	,	,	,
cord-290677-3gdcyrrz	66	26	thus	thus	RB
cord-290677-3gdcyrrz	66	27	,	,	,
cord-290677-3gdcyrrz	66	28	inflammation	inflammation	NN
cord-290677-3gdcyrrz	66	29	.	.	.
cord-290677-3gdcyrrz	67	1	In	in	IN
cord-290677-3gdcyrrz	67	2	addition	addition	NN
cord-290677-3gdcyrrz	67	3	,	,	,
cord-290677-3gdcyrrz	67	4	cytokines	cytokine	NNS
cord-290677-3gdcyrrz	67	5	such	such	JJ
cord-290677-3gdcyrrz	67	6	as	as	IN
cord-290677-3gdcyrrz	67	7	IFNγ	IFNγ	NNS
cord-290677-3gdcyrrz	67	8	,	,	,
cord-290677-3gdcyrrz	67	9	TNF	TNF	NNP
cord-290677-3gdcyrrz	67	10	and	and	CC
cord-290677-3gdcyrrz	67	11	IL-1β	IL-1β	NNP
cord-290677-3gdcyrrz	67	12	seem	seem	VBP
cord-290677-3gdcyrrz	67	13	to	to	TO
cord-290677-3gdcyrrz	67	14	influence	influence	VB
cord-290677-3gdcyrrz	67	15	both	both	CC
cord-290677-3gdcyrrz	67	16	the	the	DT
cord-290677-3gdcyrrz	67	17	expression	expression	NN
cord-290677-3gdcyrrz	67	18	and	and	CC
cord-290677-3gdcyrrz	67	19	the	the	DT
cord-290677-3gdcyrrz	67	20	activity	activity	NN
cord-290677-3gdcyrrz	67	21	of	of	IN
cord-290677-3gdcyrrz	67	22	M2	m2	JJ
cord-290677-3gdcyrrz	67	23	receptors	receptor	NNS
cord-290677-3gdcyrrz	67	24	[	[	-LRB-
cord-290677-3gdcyrrz	67	25	48	48	CD
cord-290677-3gdcyrrz	67	26	]	]	-RRB-
cord-290677-3gdcyrrz	67	27	[	[	-LRB-
cord-290677-3gdcyrrz	67	28	49	49	CD
cord-290677-3gdcyrrz	67	29	]	]	-RRB-
cord-290677-3gdcyrrz	67	30	[	[	-LRB-
cord-290677-3gdcyrrz	67	31	50	50	CD
cord-290677-3gdcyrrz	67	32	]	]	-RRB-
cord-290677-3gdcyrrz	67	33	.	.	.
cord-290677-3gdcyrrz	68	1	These	these	DT
cord-290677-3gdcyrrz	68	2	cytokines	cytokine	NNS
cord-290677-3gdcyrrz	68	3	are	be	VBP
cord-290677-3gdcyrrz	68	4	released	release	VBN
cord-290677-3gdcyrrz	68	5	in	in	IN
cord-290677-3gdcyrrz	68	6	response	response	NN
cord-290677-3gdcyrrz	68	7	to	to	IN
cord-290677-3gdcyrrz	68	8	viral	viral	JJ
cord-290677-3gdcyrrz	68	9	infection	infection	NN
cord-290677-3gdcyrrz	68	10	and	and	CC
cord-290677-3gdcyrrz	68	11	their	-PRON-	PRP$
cord-290677-3gdcyrrz	68	12	levels	level	NNS
cord-290677-3gdcyrrz	68	13	are	be	VBP
cord-290677-3gdcyrrz	68	14	increased	increase	VBN
cord-290677-3gdcyrrz	68	15	in	in	IN
cord-290677-3gdcyrrz	68	16	the	the	DT
cord-290677-3gdcyrrz	68	17	lungs	lung	NNS
cord-290677-3gdcyrrz	68	18	of	of	IN
cord-290677-3gdcyrrz	68	19	patients	patient	NNS
cord-290677-3gdcyrrz	68	20	infected	infect	VBN
cord-290677-3gdcyrrz	68	21	with	with	IN
cord-290677-3gdcyrrz	68	22	SARS	SARS	NNP
cord-290677-3gdcyrrz	68	23	-	-	HYPH
cord-290677-3gdcyrrz	68	24	CoV	CoV	NNP
cord-290677-3gdcyrrz	68	25	or	or	CC
cord-290677-3gdcyrrz	68	26	SARS	SARS	NNP
cord-290677-3gdcyrrz	68	27	-	-	HYPH
cord-290677-3gdcyrrz	68	28	CoV-2	CoV-2	NNP
cord-290677-3gdcyrrz	68	29	(	(	-LRB-
cord-290677-3gdcyrrz	68	30	refs	ref	NNS
cord-290677-3gdcyrrz	68	31	1,51,52	1,51,52	CD
cord-290677-3gdcyrrz	68	32	)	)	-RRB-
cord-290677-3gdcyrrz	68	33	.	.	.
cord-290677-3gdcyrrz	69	1	In	in	IN
cord-290677-3gdcyrrz	69	2	line	line	NN
cord-290677-3gdcyrrz	69	3	with	with	IN
cord-290677-3gdcyrrz	69	4	these	these	DT
cord-290677-3gdcyrrz	69	5	findings	finding	NNS
cord-290677-3gdcyrrz	69	6	,	,	,
cord-290677-3gdcyrrz	69	7	virus	virus	NN
cord-290677-3gdcyrrz	69	8	-	-	HYPH
cord-290677-3gdcyrrz	69	9	induced	induce	VBN
cord-290677-3gdcyrrz	69	10	airway	airway	NN
cord-290677-3gdcyrrz	69	11	hyperresponsiveness	hyperresponsiveness	NN
cord-290677-3gdcyrrz	69	12	in	in	IN
cord-290677-3gdcyrrz	69	13	humans	human	NNS
cord-290677-3gdcyrrz	69	14	seems	seem	VBZ
cord-290677-3gdcyrrz	69	15	to	to	TO
cord-290677-3gdcyrrz	69	16	be	be	VB
cord-290677-3gdcyrrz	69	17	mediated	mediate	VBN
cord-290677-3gdcyrrz	69	18	by	by	IN
cord-290677-3gdcyrrz	69	19	the	the	DT
cord-290677-3gdcyrrz	69	20	vagus	vagus	NN
cord-290677-3gdcyrrz	69	21	nerve	nerve	NN
cord-290677-3gdcyrrz	69	22	53	53	CD
cord-290677-3gdcyrrz	69	23	,	,	,
cord-290677-3gdcyrrz	69	24	raising	raise	VBG
cord-290677-3gdcyrrz	69	25	the	the	DT
cord-290677-3gdcyrrz	69	26	possibility	possibility	NN
cord-290677-3gdcyrrz	69	27	that	that	IN
cord-290677-3gdcyrrz	69	28	the	the	DT
cord-290677-3gdcyrrz	69	29	dyspnoea	dyspnoea	NNS
cord-290677-3gdcyrrz	69	30	and	and	CC
cord-290677-3gdcyrrz	69	31	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	69	32	failure	failure	NN
cord-290677-3gdcyrrz	69	33	observed	observe	VBN
cord-290677-3gdcyrrz	69	34	in	in	IN
cord-290677-3gdcyrrz	69	35	patients	patient	NNS
cord-290677-3gdcyrrz	69	36	with	with	IN
cord-290677-3gdcyrrz	69	37	severe	severe	JJ
cord-290677-3gdcyrrz	69	38	COVID-19	covid-19	NN
cord-290677-3gdcyrrz	69	39	is	be	VBZ
cord-290677-3gdcyrrz	69	40	exacerbated	exacerbate	VBN
cord-290677-3gdcyrrz	69	41	by	by	IN
cord-290677-3gdcyrrz	69	42	neuroimmune	neuroimmune	NNP
cord-290677-3gdcyrrz	69	43	crosstalk	crosstalk	NN
cord-290677-3gdcyrrz	69	44	in	in	IN
cord-290677-3gdcyrrz	69	45	the	the	DT
cord-290677-3gdcyrrz	69	46	lungs	lung	NNS
cord-290677-3gdcyrrz	69	47	.	.	.
cord-290677-3gdcyrrz	70	1	Most	Most	JJS
cord-290677-3gdcyrrz	70	2	of	of	IN
cord-290677-3gdcyrrz	70	3	the	the	DT
cord-290677-3gdcyrrz	70	4	afferent	afferent	JJ
cord-290677-3gdcyrrz	70	5	sensory	sensory	JJ
cord-290677-3gdcyrrz	70	6	fibres	fibre	NNS
cord-290677-3gdcyrrz	70	7	arising	arise	VBG
cord-290677-3gdcyrrz	70	8	from	from	IN
cord-290677-3gdcyrrz	70	9	the	the	DT
cord-290677-3gdcyrrz	70	10	airways	airways	NNP
cord-290677-3gdcyrrz	70	11	run	run	VB
cord-290677-3gdcyrrz	70	12	along	along	IN
cord-290677-3gdcyrrz	70	13	the	the	DT
cord-290677-3gdcyrrz	70	14	vagus	vagus	NN
cord-290677-3gdcyrrz	70	15	nerve	nerve	NN
cord-290677-3gdcyrrz	70	16	and	and	CC
cord-290677-3gdcyrrz	70	17	project	project	NN
cord-290677-3gdcyrrz	70	18	to	to	IN
cord-290677-3gdcyrrz	70	19	the	the	DT
cord-290677-3gdcyrrz	70	20	NTS	NTS	NNPS
cord-290677-3gdcyrrz	70	21	in	in	IN
cord-290677-3gdcyrrz	70	22	the	the	DT
cord-290677-3gdcyrrz	70	23	medulla	medulla	NN
cord-290677-3gdcyrrz	70	24	.	.	.
cord-290677-3gdcyrrz	71	1	A	a	DT
cord-290677-3gdcyrrz	71	2	small	small	JJ
cord-290677-3gdcyrrz	71	3	population	population	NN
cord-290677-3gdcyrrz	71	4	of	of	IN
cord-290677-3gdcyrrz	71	5	sensory	sensory	JJ
cord-290677-3gdcyrrz	71	6	fibres	fibre	NNS
cord-290677-3gdcyrrz	71	7	that	that	WDT
cord-290677-3gdcyrrz	71	8	innervate	innervate	VBP
cord-290677-3gdcyrrz	71	9	the	the	DT
cord-290677-3gdcyrrz	71	10	lungs	lung	NNS
cord-290677-3gdcyrrz	71	11	,	,	,
cord-290677-3gdcyrrz	71	12	known	know	VBN
cord-290677-3gdcyrrz	71	13	as	as	IN
cord-290677-3gdcyrrz	71	14	the	the	DT
cord-290677-3gdcyrrz	71	15	chemosensitive	chemosensitive	JJ
cord-290677-3gdcyrrz	71	16	C	C	NNP
cord-290677-3gdcyrrz	71	17	-	-	HYPH
cord-290677-3gdcyrrz	71	18	fibres	fibre	NNS
cord-290677-3gdcyrrz	71	19	,	,	,
cord-290677-3gdcyrrz	71	20	contain	contain	VBP
cord-290677-3gdcyrrz	71	21	neuropeptides	neuropeptide	NNS
cord-290677-3gdcyrrz	71	22	,	,	,
cord-290677-3gdcyrrz	71	23	including	include	VBG
cord-290677-3gdcyrrz	71	24	calcitonin	calcitonin	NN
cord-290677-3gdcyrrz	71	25	gene	gene	NN
cord-290677-3gdcyrrz	71	26	-	-	HYPH
cord-290677-3gdcyrrz	71	27	related	relate	VBN
cord-290677-3gdcyrrz	71	28	peptide	peptide	NN
cord-290677-3gdcyrrz	71	29	(	(	-LRB-
cord-290677-3gdcyrrz	71	30	CGRP	CGRP	NNP
cord-290677-3gdcyrrz	71	31	)	)	-RRB-
cord-290677-3gdcyrrz	71	32	and	and	CC
cord-290677-3gdcyrrz	71	33	the	the	DT
cord-290677-3gdcyrrz	71	34	tachykinins	tachykinin	NNS
cord-290677-3gdcyrrz	71	35	substance	substance	NN
cord-290677-3gdcyrrz	71	36	P	P	NNP
cord-290677-3gdcyrrz	71	37	and	and	CC
cord-290677-3gdcyrrz	71	38	neurokinin	neurokinin	NN
cord-290677-3gdcyrrz	71	39	A.	a.	NN
cord-290677-3gdcyrrz	71	40	Substance	Substance	NNP
cord-290677-3gdcyrrz	71	41	P	P	NNP
cord-290677-3gdcyrrz	71	42	and	and	CC
cord-290677-3gdcyrrz	71	43	neurokinin	neurokinin	NNP
cord-290677-3gdcyrrz	71	44	A	a	NN
cord-290677-3gdcyrrz	71	45	are	be	VBP
cord-290677-3gdcyrrz	71	46	potent	potent	JJ
cord-290677-3gdcyrrz	71	47	inducers	inducer	NNS
cord-290677-3gdcyrrz	71	48	of	of	IN
cord-290677-3gdcyrrz	71	49	airway	airway	JJ
cord-290677-3gdcyrrz	71	50	smooth	smooth	JJ
cord-290677-3gdcyrrz	71	51	muscle	muscle	NN
cord-290677-3gdcyrrz	71	52	contraction	contraction	NN
cord-290677-3gdcyrrz	71	53	,	,	,
cord-290677-3gdcyrrz	71	54	vasodilation	vasodilation	NN
cord-290677-3gdcyrrz	71	55	,	,	,
cord-290677-3gdcyrrz	71	56	bronchial	bronchial	JJ
cord-290677-3gdcyrrz	71	57	oedema	oedema	NN
cord-290677-3gdcyrrz	71	58	and	and	CC
cord-290677-3gdcyrrz	71	59	mucus	mucus	NN
cord-290677-3gdcyrrz	71	60	hypersecretion	hypersecretion	NN
cord-290677-3gdcyrrz	71	61	,	,	,
cord-290677-3gdcyrrz	71	62	which	which	WDT
cord-290677-3gdcyrrz	71	63	are	be	VBP
cord-290677-3gdcyrrz	71	64	all	all	DT
cord-290677-3gdcyrrz	71	65	typical	typical	JJ
cord-290677-3gdcyrrz	71	66	symptoms	symptom	NNS
cord-290677-3gdcyrrz	71	67	of	of	IN
cord-290677-3gdcyrrz	71	68	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	71	69	airway	airway	NN
cord-290677-3gdcyrrz	71	70	diseases	disease	NNS
cord-290677-3gdcyrrz	71	71	.	.	.
cord-290677-3gdcyrrz	72	1	A	a	DT
cord-290677-3gdcyrrz	72	2	recently	recently	RB
cord-290677-3gdcyrrz	72	3	discovered	discover	VBN
cord-290677-3gdcyrrz	72	4	class	class	NN
cord-290677-3gdcyrrz	72	5	of	of	IN
cord-290677-3gdcyrrz	72	6	vagal	vagal	JJ
cord-290677-3gdcyrrz	72	7	throat	throat	NN
cord-290677-3gdcyrrz	72	8	-	-	HYPH
cord-290677-3gdcyrrz	72	9	innervating	innervate	VBG
cord-290677-3gdcyrrz	72	10	P2RY1	P2RY1	NNP
cord-290677-3gdcyrrz	72	11	+	+	CC
cord-290677-3gdcyrrz	72	12	neurons	neuron	NNS
cord-290677-3gdcyrrz	72	13	has	have	VBZ
cord-290677-3gdcyrrz	72	14	been	be	VBN
cord-290677-3gdcyrrz	72	15	shown	show	VBN
cord-290677-3gdcyrrz	72	16	to	to	TO
cord-290677-3gdcyrrz	72	17	be	be	VB
cord-290677-3gdcyrrz	72	18	involved	involve	VBN
cord-290677-3gdcyrrz	72	19	in	in	IN
cord-290677-3gdcyrrz	72	20	protective	protective	JJ
cord-290677-3gdcyrrz	72	21	reflexes	reflex	NNS
cord-290677-3gdcyrrz	72	22	elicited	elicit	VBN
cord-290677-3gdcyrrz	72	23	by	by	IN
cord-290677-3gdcyrrz	72	24	various	various	JJ
cord-290677-3gdcyrrz	72	25	airway	airway	NN
cord-290677-3gdcyrrz	72	26	irritants	irritant	NNS
cord-290677-3gdcyrrz	72	27	54	54	CD
cord-290677-3gdcyrrz	72	28	.	.	.
cord-290677-3gdcyrrz	73	1	Although	although	IN
cord-290677-3gdcyrrz	73	2	their	-PRON-	PRP$
cord-290677-3gdcyrrz	73	3	precise	precise	JJ
cord-290677-3gdcyrrz	73	4	mechanism	mechanism	NN
cord-290677-3gdcyrrz	73	5	of	of	IN
cord-290677-3gdcyrrz	73	6	action	action	NN
cord-290677-3gdcyrrz	73	7	remains	remain	VBZ
cord-290677-3gdcyrrz	73	8	elusive	elusive	JJ
cord-290677-3gdcyrrz	73	9	,	,	,
cord-290677-3gdcyrrz	73	10	these	these	DT
cord-290677-3gdcyrrz	73	11	sensory	sensory	JJ
cord-290677-3gdcyrrz	73	12	neurons	neuron	NNS
cord-290677-3gdcyrrz	73	13	seem	seem	VBP
cord-290677-3gdcyrrz	73	14	to	to	TO
cord-290677-3gdcyrrz	73	15	detect	detect	VB
cord-290677-3gdcyrrz	73	16	cell	cell	NN
cord-290677-3gdcyrrz	73	17	mechanical	mechanical	JJ
cord-290677-3gdcyrrz	73	18	responses	response	NNS
cord-290677-3gdcyrrz	73	19	mediated	mediate	VBN
cord-290677-3gdcyrrz	73	20	by	by	IN
cord-290677-3gdcyrrz	73	21	airway	airway	NN
cord-290677-3gdcyrrz	73	22	stretch	stretch	NN
cord-290677-3gdcyrrz	73	23	receptors	receptor	NNS
cord-290677-3gdcyrrz	73	24	such	such	JJ
cord-290677-3gdcyrrz	73	25	as	as	IN
cord-290677-3gdcyrrz	73	26	Piezo2	Piezo2	NNP
cord-290677-3gdcyrrz	73	27	and	and	CC
cord-290677-3gdcyrrz	73	28	initiate	initiate	VB
cord-290677-3gdcyrrz	73	29	defensive	defensive	JJ
cord-290677-3gdcyrrz	73	30	reflexes	reflex	NNS
cord-290677-3gdcyrrz	73	31	that	that	WDT
cord-290677-3gdcyrrz	73	32	ensure	ensure	VBP
cord-290677-3gdcyrrz	73	33	airway	airway	NN
cord-290677-3gdcyrrz	73	34	integrity	integrity	NN
cord-290677-3gdcyrrz	73	35	55	55	CD
cord-290677-3gdcyrrz	73	36	.	.	.
cord-290677-3gdcyrrz	74	1	Dysfunction	dysfunction	NN
cord-290677-3gdcyrrz	74	2	of	of	IN
cord-290677-3gdcyrrz	74	3	laryngeal	laryngeal	NN
cord-290677-3gdcyrrz	74	4	neurons	neuron	NNS
cord-290677-3gdcyrrz	74	5	,	,	,
cord-290677-3gdcyrrz	74	6	which	which	WDT
cord-290677-3gdcyrrz	74	7	is	be	VBZ
cord-290677-3gdcyrrz	74	8	life	life	NN
cord-290677-3gdcyrrz	74	9	-	-	HYPH
cord-290677-3gdcyrrz	74	10	threatening	threaten	VBG
cord-290677-3gdcyrrz	74	11	and	and	CC
cord-290677-3gdcyrrz	74	12	can	can	MD
cord-290677-3gdcyrrz	74	13	cause	cause	VB
cord-290677-3gdcyrrz	74	14	pulmonary	pulmonary	JJ
cord-290677-3gdcyrrz	74	15	aspiration	aspiration	NN
cord-290677-3gdcyrrz	74	16	,	,	,
cord-290677-3gdcyrrz	74	17	dysphagia	dysphagia	NN
cord-290677-3gdcyrrz	74	18	and	and	CC
cord-290677-3gdcyrrz	74	19	choking	choking	NN
cord-290677-3gdcyrrz	74	20	,	,	,
cord-290677-3gdcyrrz	74	21	might	may	MD
cord-290677-3gdcyrrz	74	22	contribute	contribute	VB
cord-290677-3gdcyrrz	74	23	to	to	IN
cord-290677-3gdcyrrz	74	24	the	the	DT
cord-290677-3gdcyrrz	74	25	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	74	26	distress	distress	NN
cord-290677-3gdcyrrz	74	27	observed	observe	VBN
cord-290677-3gdcyrrz	74	28	in	in	IN
cord-290677-3gdcyrrz	74	29	patients	patient	NNS
cord-290677-3gdcyrrz	74	30	with	with	IN
cord-290677-3gdcyrrz	74	31	COVID-19	COVID-19	NNP
cord-290677-3gdcyrrz	74	32	.	.	.
cord-290677-3gdcyrrz	75	1	Interestingly	interestingly	RB
cord-290677-3gdcyrrz	75	2	,	,	,
cord-290677-3gdcyrrz	75	3	www.nature.com/nrneurol	www.nature.com/nrneurol	NNP
cord-290677-3gdcyrrz	75	4	altered	alter	VBN
cord-290677-3gdcyrrz	75	5	activation	activation	NN
cord-290677-3gdcyrrz	75	6	of	of	IN
cord-290677-3gdcyrrz	75	7	vagal	vagal	JJ
cord-290677-3gdcyrrz	75	8	fibres	fibre	NNS
cord-290677-3gdcyrrz	75	9	can	can	MD
cord-290677-3gdcyrrz	75	10	lead	lead	VB
cord-290677-3gdcyrrz	75	11	to	to	IN
cord-290677-3gdcyrrz	75	12	many	many	JJ
cord-290677-3gdcyrrz	75	13	of	of	IN
cord-290677-3gdcyrrz	75	14	the	the	DT
cord-290677-3gdcyrrz	75	15	symptoms	symptom	NNS
cord-290677-3gdcyrrz	75	16	of	of	IN
cord-290677-3gdcyrrz	75	17	allergic	allergic	JJ
cord-290677-3gdcyrrz	75	18	diseases	disease	NNS
cord-290677-3gdcyrrz	75	19	,	,	,
cord-290677-3gdcyrrz	75	20	such	such	JJ
cord-290677-3gdcyrrz	75	21	as	as	IN
cord-290677-3gdcyrrz	75	22	asthma	asthma	NN
cord-290677-3gdcyrrz	75	23	and	and	CC
cord-290677-3gdcyrrz	75	24	rhinitis	rhinitis	NN
cord-290677-3gdcyrrz	75	25	,	,	,
cord-290677-3gdcyrrz	75	26	and	and	CC
cord-290677-3gdcyrrz	75	27	of	of	IN
cord-290677-3gdcyrrz	75	28	chronic	chronic	JJ
cord-290677-3gdcyrrz	75	29	obstructive	obstructive	JJ
cord-290677-3gdcyrrz	75	30	pulmonary	pulmonary	JJ
cord-290677-3gdcyrrz	75	31	disease	disease	NN
cord-290677-3gdcyrrz	75	32	(	(	-LRB-
cord-290677-3gdcyrrz	75	33	COPD	COPD	NNP
cord-290677-3gdcyrrz	75	34	)	)	-RRB-
cord-290677-3gdcyrrz	75	35	,	,	,
cord-290677-3gdcyrrz	75	36	including	include	VBG
cord-290677-3gdcyrrz	75	37	sneezing	sneeze	VBG
cord-290677-3gdcyrrz	75	38	,	,	,
cord-290677-3gdcyrrz	75	39	coughing	coughing	NN
cord-290677-3gdcyrrz	75	40	,	,	,
cord-290677-3gdcyrrz	75	41	mucus	mucus	NN
cord-290677-3gdcyrrz	75	42	hypersecretion	hypersecretion	NN
cord-290677-3gdcyrrz	75	43	and	and	CC
cord-290677-3gdcyrrz	75	44	bronchoconstriction	bronchoconstriction	VBP
cord-290677-3gdcyrrz	75	45	42	42	CD
cord-290677-3gdcyrrz	75	46	,	,	,
cord-290677-3gdcyrrz	75	47	56	56	CD
cord-290677-3gdcyrrz	75	48	.	.	.
cord-290677-3gdcyrrz	76	1	Another	another	DT
cord-290677-3gdcyrrz	76	2	class	class	NN
cord-290677-3gdcyrrz	76	3	of	of	IN
cord-290677-3gdcyrrz	76	4	sensors	sensor	NNS
cord-290677-3gdcyrrz	76	5	that	that	WDT
cord-290677-3gdcyrrz	76	6	are	be	VBP
cord-290677-3gdcyrrz	76	7	present	present	JJ
cord-290677-3gdcyrrz	76	8	in	in	IN
cord-290677-3gdcyrrz	76	9	the	the	DT
cord-290677-3gdcyrrz	76	10	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	76	11	tract	tract	NN
cord-290677-3gdcyrrz	76	12	are	be	VBP
cord-290677-3gdcyrrz	76	13	the	the	DT
cord-290677-3gdcyrrz	76	14	neuroepithelial	neuroepithelial	JJ
cord-290677-3gdcyrrz	76	15	cell	cell	NN
cord-290677-3gdcyrrz	76	16	bodies	body	NNS
cord-290677-3gdcyrrz	76	17	(	(	-LRB-
cord-290677-3gdcyrrz	76	18	NEBs	neb	NNS
cord-290677-3gdcyrrz	76	19	)	)	-RRB-
cord-290677-3gdcyrrz	76	20	.	.	.
cord-290677-3gdcyrrz	77	1	NEBs	neb	NNS
cord-290677-3gdcyrrz	77	2	contain	contain	VBP
cord-290677-3gdcyrrz	77	3	several	several	JJ
cord-290677-3gdcyrrz	77	4	bioactive	bioactive	JJ
cord-290677-3gdcyrrz	77	5	mediators	mediator	NNS
cord-290677-3gdcyrrz	77	6	,	,	,
cord-290677-3gdcyrrz	77	7	including	include	VBG
cord-290677-3gdcyrrz	77	8	bombesin	bombesin	NNP
cord-290677-3gdcyrrz	77	9	,	,	,
cord-290677-3gdcyrrz	77	10	CGRP	CGRP	NNP
cord-290677-3gdcyrrz	77	11	,	,	,
cord-290677-3gdcyrrz	77	12	5-hydroxytryptamine	5-hydroxytryptamine	CD
cord-290677-3gdcyrrz	77	13	and	and	CC
cord-290677-3gdcyrrz	77	14	ATP	ATP	NNP
cord-290677-3gdcyrrz	77	15	57	57	CD
cord-290677-3gdcyrrz	77	16	.	.	.
cord-290677-3gdcyrrz	78	1	They	-PRON-	PRP
cord-290677-3gdcyrrz	78	2	form	form	VBP
cord-290677-3gdcyrrz	78	3	compact	compact	JJ
cord-290677-3gdcyrrz	78	4	structures	structure	NNS
cord-290677-3gdcyrrz	78	5	located	locate	VBN
cord-290677-3gdcyrrz	78	6	within	within	IN
cord-290677-3gdcyrrz	78	7	the	the	DT
cord-290677-3gdcyrrz	78	8	airway	airway	NN
cord-290677-3gdcyrrz	78	9	mucosa	mucosa	NN
cord-290677-3gdcyrrz	78	10	with	with	IN
cord-290677-3gdcyrrz	78	11	their	-PRON-	PRP$
cord-290677-3gdcyrrz	78	12	apical	apical	JJ
cord-290677-3gdcyrrz	78	13	surface	surface	NN
cord-290677-3gdcyrrz	78	14	exposed	expose	VBN
cord-290677-3gdcyrrz	78	15	to	to	IN
cord-290677-3gdcyrrz	78	16	the	the	DT
cord-290677-3gdcyrrz	78	17	airway	airway	NN
cord-290677-3gdcyrrz	78	18	lumen	lumen	NN
cord-290677-3gdcyrrz	78	19	and	and	CC
cord-290677-3gdcyrrz	78	20	are	be	VBP
cord-290677-3gdcyrrz	78	21	innervated	innervate	VBN
cord-290677-3gdcyrrz	78	22	mostly	mostly	RB
cord-290677-3gdcyrrz	78	23	by	by	IN
cord-290677-3gdcyrrz	78	24	vagal	vagal	JJ
cord-290677-3gdcyrrz	78	25	afferent	afferent	JJ
cord-290677-3gdcyrrz	78	26	fibres	fibre	NNS
cord-290677-3gdcyrrz	78	27	58	58	CD
cord-290677-3gdcyrrz	78	28	.	.	.
cord-290677-3gdcyrrz	79	1	NEBs	neb	NNS
cord-290677-3gdcyrrz	79	2	are	be	VBP
cord-290677-3gdcyrrz	79	3	multimodal	multimodal	NN
cord-290677-3gdcyrrz	79	4	sensors	sensor	NNS
cord-290677-3gdcyrrz	79	5	that	that	WDT
cord-290677-3gdcyrrz	79	6	respond	respond	VBP
cord-290677-3gdcyrrz	79	7	to	to	IN
cord-290677-3gdcyrrz	79	8	a	a	DT
cord-290677-3gdcyrrz	79	9	range	range	NN
cord-290677-3gdcyrrz	79	10	of	of	IN
cord-290677-3gdcyrrz	79	11	stimuli	stimulus	NNS
cord-290677-3gdcyrrz	79	12	in	in	IN
cord-290677-3gdcyrrz	79	13	the	the	DT
cord-290677-3gdcyrrz	79	14	airway	airway	NN
cord-290677-3gdcyrrz	79	15	lumen	lumen	NN
cord-290677-3gdcyrrz	79	16	,	,	,
cord-290677-3gdcyrrz	79	17	including	include	VBG
cord-290677-3gdcyrrz	79	18	hypoxia	hypoxia	NN
cord-290677-3gdcyrrz	79	19	,	,	,
cord-290677-3gdcyrrz	79	20	hypercapnia	hypercapnia	NN
cord-290677-3gdcyrrz	79	21	,	,	,
cord-290677-3gdcyrrz	79	22	mechanical	mechanical	JJ
cord-290677-3gdcyrrz	79	23	stretch	stretch	NN
cord-290677-3gdcyrrz	79	24	,	,	,
cord-290677-3gdcyrrz	79	25	nicotine	nicotine	NN
cord-290677-3gdcyrrz	79	26	and	and	CC
cord-290677-3gdcyrrz	79	27	nociceptive	nociceptive	JJ
cord-290677-3gdcyrrz	79	28	irritants	irritant	NNS
cord-290677-3gdcyrrz	79	29	59	59	CD
cord-290677-3gdcyrrz	79	30	,	,	,
cord-290677-3gdcyrrz	79	31	60	60	CD
cord-290677-3gdcyrrz	79	32	.	.	.
cord-290677-3gdcyrrz	80	1	Hyperplasia	hyperplasia	NN
cord-290677-3gdcyrrz	80	2	of	of	IN
cord-290677-3gdcyrrz	80	3	NEBs	neb	NNS
cord-290677-3gdcyrrz	80	4	has	have	VBZ
cord-290677-3gdcyrrz	80	5	been	be	VBN
cord-290677-3gdcyrrz	80	6	reported	report	VBN
cord-290677-3gdcyrrz	80	7	in	in	IN
cord-290677-3gdcyrrz	80	8	a	a	DT
cord-290677-3gdcyrrz	80	9	number	number	NN
cord-290677-3gdcyrrz	80	10	of	of	IN
cord-290677-3gdcyrrz	80	11	paediatric	paediatric	JJ
cord-290677-3gdcyrrz	80	12	and	and	CC
cord-290677-3gdcyrrz	80	13	adult	adult	NN
cord-290677-3gdcyrrz	80	14	lung	lung	NN
cord-290677-3gdcyrrz	80	15	diseases	disease	NNS
cord-290677-3gdcyrrz	80	16	,	,	,
cord-290677-3gdcyrrz	80	17	including	include	VBG
cord-290677-3gdcyrrz	80	18	viral	viral	JJ
cord-290677-3gdcyrrz	80	19	infections	infection	NNS
cord-290677-3gdcyrrz	80	20	,	,	,
cord-290677-3gdcyrrz	80	21	many	many	JJ
cord-290677-3gdcyrrz	80	22	of	of	IN
cord-290677-3gdcyrrz	80	23	which	which	WDT
cord-290677-3gdcyrrz	80	24	are	be	VBP
cord-290677-3gdcyrrz	80	25	associated	associate	VBN
cord-290677-3gdcyrrz	80	26	with	with	IN
cord-290677-3gdcyrrz	80	27	symptoms	symptom	NNS
cord-290677-3gdcyrrz	80	28	of	of	IN
cord-290677-3gdcyrrz	80	29	dyspnoea	dyspnoea	NNS
cord-290677-3gdcyrrz	80	30	on	on	IN
cord-290677-3gdcyrrz	80	31	presentation	presentation	NN
cord-290677-3gdcyrrz	80	32	57	57	CD
cord-290677-3gdcyrrz	80	33	,	,	,
cord-290677-3gdcyrrz	80	34	61	61	CD
cord-290677-3gdcyrrz	80	35	.	.	.
cord-290677-3gdcyrrz	81	1	The	the	DT
cord-290677-3gdcyrrz	81	2	effects	effect	NNS
cord-290677-3gdcyrrz	81	3	of	of	IN
cord-290677-3gdcyrrz	81	4	NEB	neb	NN
cord-290677-3gdcyrrz	81	5	-	-	HYPH
cord-290677-3gdcyrrz	81	6	derived	derive	VBN
cord-290677-3gdcyrrz	81	7	CGRP	CGRP	NNP
cord-290677-3gdcyrrz	81	8	include	include	VBP
cord-290677-3gdcyrrz	81	9	bronchoconstriction	bronchoconstriction	NN
cord-290677-3gdcyrrz	81	10	,	,	,
cord-290677-3gdcyrrz	81	11	vasodilation	vasodilation	NN
cord-290677-3gdcyrrz	81	12	and	and	CC
cord-290677-3gdcyrrz	81	13	modulation	modulation	NN
cord-290677-3gdcyrrz	81	14	of	of	IN
cord-290677-3gdcyrrz	81	15	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	81	16	responses	response	NNS
cord-290677-3gdcyrrz	81	17	in	in	IN
cord-290677-3gdcyrrz	81	18	the	the	DT
cord-290677-3gdcyrrz	81	19	lung	lung	NN
cord-290677-3gdcyrrz	81	20	62	62	CD
cord-290677-3gdcyrrz	81	21	.	.	.
cord-290677-3gdcyrrz	82	1	Bombesin	Bombesin	NNP
cord-290677-3gdcyrrz	82	2	,	,	,
cord-290677-3gdcyrrz	82	3	the	the	DT
cord-290677-3gdcyrrz	82	4	principal	principal	JJ
cord-290677-3gdcyrrz	82	5	peptide	peptide	NN
cord-290677-3gdcyrrz	82	6	in	in	IN
cord-290677-3gdcyrrz	82	7	human	human	JJ
cord-290677-3gdcyrrz	82	8	NEBs	neb	NNS
cord-290677-3gdcyrrz	82	9	,	,	,
cord-290677-3gdcyrrz	82	10	might	may	MD
cord-290677-3gdcyrrz	82	11	also	also	RB
cord-290677-3gdcyrrz	82	12	be	be	VB
cord-290677-3gdcyrrz	82	13	involved	involve	VBN
cord-290677-3gdcyrrz	82	14	in	in	IN
cord-290677-3gdcyrrz	82	15	modulating	modulate	VBG
cord-290677-3gdcyrrz	82	16	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	82	17	function	function	NN
cord-290677-3gdcyrrz	82	18	and	and	CC
cord-290677-3gdcyrrz	82	19	immune	immune	JJ
cord-290677-3gdcyrrz	82	20	responses	response	NNS
cord-290677-3gdcyrrz	82	21	in	in	IN
cord-290677-3gdcyrrz	82	22	the	the	DT
cord-290677-3gdcyrrz	82	23	lungs	lung	NNS
cord-290677-3gdcyrrz	82	24	either	either	CC
cord-290677-3gdcyrrz	82	25	by	by	IN
cord-290677-3gdcyrrz	82	26	directly	directly	RB
cord-290677-3gdcyrrz	82	27	inducing	induce	VBG
cord-290677-3gdcyrrz	82	28	bronchoconstriction	bronchoconstriction	NN
cord-290677-3gdcyrrz	82	29	or	or	CC
cord-290677-3gdcyrrz	82	30	by	by	IN
cord-290677-3gdcyrrz	82	31	signalling	signal	VBG
cord-290677-3gdcyrrz	82	32	to	to	IN
cord-290677-3gdcyrrz	82	33	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	82	34	cells	cell	NNS
cord-290677-3gdcyrrz	82	35	63	63	CD
cord-290677-3gdcyrrz	82	36	,	,	,
cord-290677-3gdcyrrz	82	37	64	64	CD
cord-290677-3gdcyrrz	82	38	.	.	.
cord-290677-3gdcyrrz	83	1	Importantly	importantly	RB
cord-290677-3gdcyrrz	83	2	,	,	,
cord-290677-3gdcyrrz	83	3	in	in	IN
cord-290677-3gdcyrrz	83	4	a	a	DT
cord-290677-3gdcyrrz	83	5	number	number	NN
cord-290677-3gdcyrrz	83	6	of	of	IN
cord-290677-3gdcyrrz	83	7	studies	study	NNS
cord-290677-3gdcyrrz	83	8	the	the	DT
cord-290677-3gdcyrrz	83	9	vagus	vagus	NNP
cord-290677-3gdcyrrz	83	10	nerve	nerve	NN
cord-290677-3gdcyrrz	83	11	has	have	VBZ
cord-290677-3gdcyrrz	83	12	been	be	VBN
cord-290677-3gdcyrrz	83	13	found	find	VBN
cord-290677-3gdcyrrz	83	14	to	to	TO
cord-290677-3gdcyrrz	83	15	have	have	VB
cord-290677-3gdcyrrz	83	16	an	an	DT
cord-290677-3gdcyrrz	83	17	immunomodulatory	immunomodulatory	NN
cord-290677-3gdcyrrz	83	18	(	(	-LRB-
cord-290677-3gdcyrrz	83	19	but	but	CC
cord-290677-3gdcyrrz	83	20	mainly	mainly	RB
cord-290677-3gdcyrrz	83	21	anti	anti	JJ
cord-290677-3gdcyrrz	83	22	-	-	JJ
cord-290677-3gdcyrrz	83	23	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	83	24	)	)	-RRB-
cord-290677-3gdcyrrz	83	25	function	function	NN
cord-290677-3gdcyrrz	83	26	[	[	-LRB-
cord-290677-3gdcyrrz	83	27	65	65	CD
cord-290677-3gdcyrrz	83	28	]	]	-RRB-
cord-290677-3gdcyrrz	84	1	[	[	-LRB-
cord-290677-3gdcyrrz	84	2	66	66	CD
cord-290677-3gdcyrrz	84	3	]	]	-RRB-
cord-290677-3gdcyrrz	85	1	[	[	-LRB-
cord-290677-3gdcyrrz	85	2	67	67	CD
cord-290677-3gdcyrrz	85	3	]	]	-RRB-
cord-290677-3gdcyrrz	85	4	[	[	-LRB-
cord-290677-3gdcyrrz	85	5	68	68	CD
cord-290677-3gdcyrrz	85	6	]	]	-RRB-
cord-290677-3gdcyrrz	85	7	.	.	.
cord-290677-3gdcyrrz	86	1	The	the	DT
cord-290677-3gdcyrrz	86	2	immunomodulatory	immunomodulatory	JJ
cord-290677-3gdcyrrz	86	3	effects	effect	NNS
cord-290677-3gdcyrrz	86	4	seem	seem	VBP
cord-290677-3gdcyrrz	86	5	to	to	TO
cord-290677-3gdcyrrz	86	6	be	be	VB
cord-290677-3gdcyrrz	86	7	mediated	mediate	VBN
cord-290677-3gdcyrrz	86	8	by	by	IN
cord-290677-3gdcyrrz	86	9	three	three	CD
cord-290677-3gdcyrrz	86	10	different	different	JJ
cord-290677-3gdcyrrz	86	11	pathways	pathway	NNS
cord-290677-3gdcyrrz	86	12	.	.	.
cord-290677-3gdcyrrz	87	1	The	the	DT
cord-290677-3gdcyrrz	87	2	first	first	JJ
cord-290677-3gdcyrrz	87	3	pathway	pathway	NN
cord-290677-3gdcyrrz	87	4	is	be	VBZ
cord-290677-3gdcyrrz	87	5	the	the	DT
cord-290677-3gdcyrrz	87	6	neuroendocrine	neuroendocrine	JJ
cord-290677-3gdcyrrz	87	7	immune	immune	JJ
cord-290677-3gdcyrrz	87	8	axis	axis	NN
cord-290677-3gdcyrrz	87	9	that	that	WDT
cord-290677-3gdcyrrz	87	10	connects	connect	VBZ
cord-290677-3gdcyrrz	87	11	the	the	DT
cord-290677-3gdcyrrz	87	12	CNS	CNS	NNP
cord-290677-3gdcyrrz	87	13	with	with	IN
cord-290677-3gdcyrrz	87	14	the	the	DT
cord-290677-3gdcyrrz	87	15	intestinal	intestinal	JJ
cord-290677-3gdcyrrz	87	16	immune	immune	JJ
cord-290677-3gdcyrrz	87	17	system	system	NN
cord-290677-3gdcyrrz	87	18	,	,	,
cord-290677-3gdcyrrz	87	19	where	where	WRB
cord-290677-3gdcyrrz	87	20	pro	pro	JJ
cord-290677-3gdcyrrz	87	21	-	-	JJ
cord-290677-3gdcyrrz	87	22	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	87	23	cytokines	cytokine	NNS
cord-290677-3gdcyrrz	87	24	(	(	-LRB-
cord-290677-3gdcyrrz	87	25	IL-1β	IL-1β	NNP
cord-290677-3gdcyrrz	87	26	,	,	,
cord-290677-3gdcyrrz	87	27	IL-6	IL-6	NNP
cord-290677-3gdcyrrz	87	28	and	and	CC
cord-290677-3gdcyrrz	87	29	TNF	TNF	NNP
cord-290677-3gdcyrrz	87	30	)	)	-RRB-
cord-290677-3gdcyrrz	87	31	released	release	VBN
cord-290677-3gdcyrrz	87	32	from	from	IN
cord-290677-3gdcyrrz	87	33	the	the	DT
cord-290677-3gdcyrrz	87	34	intestinal	intestinal	JJ
cord-290677-3gdcyrrz	87	35	mucosa	mucosa	NN
cord-290677-3gdcyrrz	87	36	activate	activate	VBP
cord-290677-3gdcyrrz	87	37	vagal	vagal	JJ
cord-290677-3gdcyrrz	87	38	afferents	afferent	NNS
cord-290677-3gdcyrrz	87	39	that	that	WDT
cord-290677-3gdcyrrz	87	40	terminate	terminate	VBP
cord-290677-3gdcyrrz	87	41	in	in	IN
cord-290677-3gdcyrrz	87	42	the	the	DT
cord-290677-3gdcyrrz	87	43	NTS	NTS	NNP
cord-290677-3gdcyrrz	87	44	65	65	CD
cord-290677-3gdcyrrz	87	45	.	.	.
cord-290677-3gdcyrrz	88	1	The	the	DT
cord-290677-3gdcyrrz	88	2	second	second	JJ
cord-290677-3gdcyrrz	88	3	pathway	pathway	NN
cord-290677-3gdcyrrz	88	4	is	be	VBZ
cord-290677-3gdcyrrz	88	5	the	the	DT
cord-290677-3gdcyrrz	88	6	splenic	splenic	JJ
cord-290677-3gdcyrrz	88	7	sympathetic	sympathetic	JJ
cord-290677-3gdcyrrz	88	8	anti	anti	JJ
cord-290677-3gdcyrrz	88	9	-	-	JJ
cord-290677-3gdcyrrz	88	10	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	88	11	pathway	pathway	NN
cord-290677-3gdcyrrz	88	12	,	,	,
cord-290677-3gdcyrrz	88	13	in	in	IN
cord-290677-3gdcyrrz	88	14	which	which	WDT
cord-290677-3gdcyrrz	88	15	the	the	DT
cord-290677-3gdcyrrz	88	16	vagus	vagus	NN
cord-290677-3gdcyrrz	88	17	nerve	nerve	NN
cord-290677-3gdcyrrz	88	18	stimulates	stimulate	VBZ
cord-290677-3gdcyrrz	88	19	the	the	DT
cord-290677-3gdcyrrz	88	20	splenic	splenic	JJ
cord-290677-3gdcyrrz	88	21	sympathetic	sympathetic	JJ
cord-290677-3gdcyrrz	88	22	nerve	nerve	NN
cord-290677-3gdcyrrz	88	23	.	.	.
cord-290677-3gdcyrrz	89	1	In	in	IN
cord-290677-3gdcyrrz	89	2	this	this	DT
cord-290677-3gdcyrrz	89	3	pathway	pathway	NN
cord-290677-3gdcyrrz	89	4	,	,	,
cord-290677-3gdcyrrz	89	5	noradrenaline	noradrenaline	NN
cord-290677-3gdcyrrz	89	6	released	release	VBN
cord-290677-3gdcyrrz	89	7	at	at	IN
cord-290677-3gdcyrrz	89	8	the	the	DT
cord-290677-3gdcyrrz	89	9	distal	distal	JJ
cord-290677-3gdcyrrz	89	10	end	end	NN
cord-290677-3gdcyrrz	89	11	of	of	IN
cord-290677-3gdcyrrz	89	12	the	the	DT
cord-290677-3gdcyrrz	89	13	splenic	splenic	JJ
cord-290677-3gdcyrrz	89	14	nerve	nerve	NN
cord-290677-3gdcyrrz	89	15	activates	activate	VBZ
cord-290677-3gdcyrrz	89	16	β2	β2	NN
cord-290677-3gdcyrrz	89	17	adrenergic	adrenergic	JJ
cord-290677-3gdcyrrz	89	18	receptors	receptor	NNS
cord-290677-3gdcyrrz	89	19	of	of	IN
cord-290677-3gdcyrrz	89	20	splenic	splenic	JJ
cord-290677-3gdcyrrz	89	21	lymphocytes	lymphocyte	NNS
cord-290677-3gdcyrrz	89	22	,	,	,
cord-290677-3gdcyrrz	89	23	which	which	WDT
cord-290677-3gdcyrrz	89	24	release	release	VBP
cord-290677-3gdcyrrz	89	25	acetylcholine	acetylcholine	NN
cord-290677-3gdcyrrz	89	26	.	.	.
cord-290677-3gdcyrrz	90	1	In	in	IN
cord-290677-3gdcyrrz	90	2	turn	turn	NN
cord-290677-3gdcyrrz	90	3	,	,	,
cord-290677-3gdcyrrz	90	4	The	the	DT
cord-290677-3gdcyrrz	90	5	vagus	vagus	JJ
cord-290677-3gdcyrrz	90	6	nerve	nerve	NN
cord-290677-3gdcyrrz	90	7	originates	originate	VBZ
cord-290677-3gdcyrrz	90	8	in	in	IN
cord-290677-3gdcyrrz	90	9	the	the	DT
cord-290677-3gdcyrrz	90	10	brainstem	brainstem	NN
cord-290677-3gdcyrrz	90	11	and	and	CC
cord-290677-3gdcyrrz	90	12	provides	provide	VBZ
cord-290677-3gdcyrrz	90	13	most	most	JJS
cord-290677-3gdcyrrz	90	14	of	of	IN
cord-290677-3gdcyrrz	90	15	the	the	DT
cord-290677-3gdcyrrz	90	16	sensory	sensory	NN
cord-290677-3gdcyrrz	90	17	and	and	CC
cord-290677-3gdcyrrz	90	18	all	all	DT
cord-290677-3gdcyrrz	90	19	of	of	IN
cord-290677-3gdcyrrz	90	20	the	the	DT
cord-290677-3gdcyrrz	90	21	parasympathetic	parasympathetic	JJ
cord-290677-3gdcyrrz	90	22	nerve	nerve	NN
cord-290677-3gdcyrrz	90	23	fibres	fibre	NNS
cord-290677-3gdcyrrz	90	24	that	that	WDT
cord-290677-3gdcyrrz	90	25	innervate	innervate	VBP
cord-290677-3gdcyrrz	90	26	the	the	DT
cord-290677-3gdcyrrz	90	27	airways	airways	NNPS
cord-290677-3gdcyrrz	90	28	,	,	,
cord-290677-3gdcyrrz	90	29	via	via	IN
cord-290677-3gdcyrrz	90	30	the	the	DT
cord-290677-3gdcyrrz	90	31	jugular	jugular	NN
cord-290677-3gdcyrrz	90	32	and	and	CC
cord-290677-3gdcyrrz	90	33	nodose	nodose	JJ
cord-290677-3gdcyrrz	90	34	ganglia	ganglion	NNS
cord-290677-3gdcyrrz	90	35	(	(	-LRB-
cord-290677-3gdcyrrz	90	36	sensory	sensory	JJ
cord-290677-3gdcyrrz	90	37	)	)	-RRB-
cord-290677-3gdcyrrz	90	38	and	and	CC
cord-290677-3gdcyrrz	90	39	petrosal	petrosal	NN
cord-290677-3gdcyrrz	90	40	ganglion	ganglion	NN
cord-290677-3gdcyrrz	90	41	(	(	-LRB-
cord-290677-3gdcyrrz	90	42	parasympathetic	parasympathetic	NN
cord-290677-3gdcyrrz	90	43	)	)	-RRB-
cord-290677-3gdcyrrz	90	44	.	.	.
cord-290677-3gdcyrrz	91	1	A	a	DT
cord-290677-3gdcyrrz	91	2	minority	minority	NN
cord-290677-3gdcyrrz	91	3	of	of	IN
cord-290677-3gdcyrrz	91	4	sensory	sensory	JJ
cord-290677-3gdcyrrz	91	5	fibres	fibre	NNS
cord-290677-3gdcyrrz	91	6	in	in	IN
cord-290677-3gdcyrrz	91	7	the	the	DT
cord-290677-3gdcyrrz	91	8	lungs	lung	NNS
cord-290677-3gdcyrrz	91	9	originate	originate	VBP
cord-290677-3gdcyrrz	91	10	in	in	IN
cord-290677-3gdcyrrz	91	11	the	the	DT
cord-290677-3gdcyrrz	91	12	T1-T6	T1-T6	NNP
cord-290677-3gdcyrrz	91	13	dorsal	dorsal	JJ
cord-290677-3gdcyrrz	91	14	root	root	NN
cord-290677-3gdcyrrz	91	15	ganglia	ganglion	NNS
cord-290677-3gdcyrrz	91	16	and	and	CC
cord-290677-3gdcyrrz	91	17	run	run	VBN
cord-290677-3gdcyrrz	91	18	in	in	IN
cord-290677-3gdcyrrz	91	19	spinal	spinal	JJ
cord-290677-3gdcyrrz	91	20	nerves	nerve	NNS
cord-290677-3gdcyrrz	91	21	along	along	IN
cord-290677-3gdcyrrz	91	22	with	with	IN
cord-290677-3gdcyrrz	91	23	sympathetic	sympathetic	JJ
cord-290677-3gdcyrrz	91	24	fibres	fibre	NNS
cord-290677-3gdcyrrz	91	25	originating	originate	VBG
cord-290677-3gdcyrrz	91	26	in	in	IN
cord-290677-3gdcyrrz	91	27	the	the	DT
cord-290677-3gdcyrrz	91	28	thoracic	thoracic	JJ
cord-290677-3gdcyrrz	91	29	ganglia	ganglion	NNS
cord-290677-3gdcyrrz	91	30	.	.	.
cord-290677-3gdcyrrz	92	1	The	the	DT
cord-290677-3gdcyrrz	92	2	insets	inset	NNS
cord-290677-3gdcyrrz	92	3	show	show	VBP
cord-290677-3gdcyrrz	92	4	the	the	DT
cord-290677-3gdcyrrz	92	5	principal	principal	JJ
cord-290677-3gdcyrrz	92	6	neurotransmitters	neurotransmitter	NNS
cord-290677-3gdcyrrz	92	7	originating	originate	VBG
cord-290677-3gdcyrrz	92	8	from	from	IN
cord-290677-3gdcyrrz	92	9	the	the	DT
cord-290677-3gdcyrrz	92	10	fibres	fibre	NNS
cord-290677-3gdcyrrz	92	11	that	that	WDT
cord-290677-3gdcyrrz	92	12	innervate	innervate	VBP
cord-290677-3gdcyrrz	92	13	the	the	DT
cord-290677-3gdcyrrz	92	14	airways	airways	NNPS
cord-290677-3gdcyrrz	92	15	and	and	CC
cord-290677-3gdcyrrz	92	16	the	the	DT
cord-290677-3gdcyrrz	92	17	target	target	NN
cord-290677-3gdcyrrz	92	18	receptors	receptor	NNS
cord-290677-3gdcyrrz	92	19	of	of	IN
cord-290677-3gdcyrrz	92	20	these	these	DT
cord-290677-3gdcyrrz	92	21	neurotransmitters	neurotransmitter	NNS
cord-290677-3gdcyrrz	92	22	.	.	.
cord-290677-3gdcyrrz	93	1	5-HT	5-ht	CD
cord-290677-3gdcyrrz	93	2	,	,	,
cord-290677-3gdcyrrz	94	1	5-hydroxytryptamine	5-hydroxytryptamine	CD
cord-290677-3gdcyrrz	94	2	;	;	:
cord-290677-3gdcyrrz	94	3	ACh	ACh	NNP
cord-290677-3gdcyrrz	94	4	,	,	,
cord-290677-3gdcyrrz	94	5	acetylcholine	acetylcholine	NN
cord-290677-3gdcyrrz	94	6	;	;	:
cord-290677-3gdcyrrz	94	7	CGRP	CGRP	NNP
cord-290677-3gdcyrrz	94	8	,	,	,
cord-290677-3gdcyrrz	94	9	calcitonin	calcitonin	NN
cord-290677-3gdcyrrz	94	10	gene	gene	NN
cord-290677-3gdcyrrz	94	11	-	-	HYPH
cord-290677-3gdcyrrz	94	12	related	relate	VBN
cord-290677-3gdcyrrz	94	13	peptide	peptide	NN
cord-290677-3gdcyrrz	94	14	;	;	:
cord-290677-3gdcyrrz	94	15	mAChR	mAChR	NNP
cord-290677-3gdcyrrz	94	16	,	,	,
cord-290677-3gdcyrrz	94	17	muscarinic	muscarinic	NNP
cord-290677-3gdcyrrz	94	18	ACh	ACh	NNP
cord-290677-3gdcyrrz	94	19	receptor	receptor	NN
cord-290677-3gdcyrrz	94	20	;	;	:
cord-290677-3gdcyrrz	94	21	nAChR	nAChR	NNP
cord-290677-3gdcyrrz	94	22	,	,	,
cord-290677-3gdcyrrz	94	23	nicotinic	nicotinic	NNP
cord-290677-3gdcyrrz	94	24	ACh	ACh	NNP
cord-290677-3gdcyrrz	94	25	receptor	receptor	NN
cord-290677-3gdcyrrz	94	26	;	;	:
cord-290677-3gdcyrrz	94	27	NO	no	UH
cord-290677-3gdcyrrz	94	28	,	,	,
cord-290677-3gdcyrrz	94	29	nitric	nitric	JJ
cord-290677-3gdcyrrz	94	30	oxide	oxide	NN
cord-290677-3gdcyrrz	94	31	;	;	:
cord-290677-3gdcyrrz	94	32	SK	SK	NNP
cord-290677-3gdcyrrz	94	33	,	,	,
cord-290677-3gdcyrrz	94	34	substance	substance	NN
cord-290677-3gdcyrrz	94	35	K	K	NNP
cord-290677-3gdcyrrz	94	36	;	;	:
cord-290677-3gdcyrrz	94	37	SP	SP	NNP
cord-290677-3gdcyrrz	94	38	,	,	,
cord-290677-3gdcyrrz	94	39	substance	substance	NN
cord-290677-3gdcyrrz	94	40	P.	p.	NN
cord-290677-3gdcyrrz	94	41	acetylcholine	acetylcholine	NN
cord-290677-3gdcyrrz	94	42	inhibits	inhibit	VBZ
cord-290677-3gdcyrrz	94	43	the	the	DT
cord-290677-3gdcyrrz	94	44	release	release	NN
cord-290677-3gdcyrrz	94	45	of	of	IN
cord-290677-3gdcyrrz	94	46	TNF	TNF	NNP
cord-290677-3gdcyrrz	94	47	by	by	IN
cord-290677-3gdcyrrz	94	48	spleen	spleen	NN
cord-290677-3gdcyrrz	94	49	macrophages	macrophage	NNS
cord-290677-3gdcyrrz	94	50	through	through	IN
cord-290677-3gdcyrrz	94	51	α7	α7	NNP
cord-290677-3gdcyrrz	94	52	nicotinic	nicotinic	JJ
cord-290677-3gdcyrrz	94	53	acetylcholine	acetylcholine	NN
cord-290677-3gdcyrrz	94	54	receptors	receptor	NNS
cord-290677-3gdcyrrz	94	55	(	(	-LRB-
cord-290677-3gdcyrrz	94	56	α7nAChRs	α7nachrs	ADD
cord-290677-3gdcyrrz	94	57	)	)	-RRB-
cord-290677-3gdcyrrz	94	58	.	.	.
cord-290677-3gdcyrrz	95	1	The	the	DT
cord-290677-3gdcyrrz	95	2	third	third	JJ
cord-290677-3gdcyrrz	95	3	pathway	pathway	NN
cord-290677-3gdcyrrz	95	4	is	be	VBZ
cord-290677-3gdcyrrz	95	5	the	the	DT
cord-290677-3gdcyrrz	95	6	cholinergic	cholinergic	JJ
cord-290677-3gdcyrrz	95	7	anti	anti	JJ
cord-290677-3gdcyrrz	95	8	-	-	JJ
cord-290677-3gdcyrrz	95	9	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	95	10	pathway	pathway	NN
cord-290677-3gdcyrrz	95	11	mediated	mediate	VBN
cord-290677-3gdcyrrz	95	12	through	through	IN
cord-290677-3gdcyrrz	95	13	vagal	vagal	JJ
cord-290677-3gdcyrrz	95	14	efferent	efferent	JJ
cord-290677-3gdcyrrz	95	15	fibres	fibre	NNS
cord-290677-3gdcyrrz	95	16	that	that	WDT
cord-290677-3gdcyrrz	95	17	synapse	synapse	NN
cord-290677-3gdcyrrz	95	18	onto	onto	IN
cord-290677-3gdcyrrz	95	19	enteric	enteric	JJ
cord-290677-3gdcyrrz	95	20	neurons	neuron	NNS
cord-290677-3gdcyrrz	95	21	,	,	,
cord-290677-3gdcyrrz	95	22	which	which	WDT
cord-290677-3gdcyrrz	95	23	in	in	IN
cord-290677-3gdcyrrz	95	24	turn	turn	NN
cord-290677-3gdcyrrz	95	25	release	release	VBZ
cord-290677-3gdcyrrz	95	26	acetylcholine	acetylcholine	NN
cord-290677-3gdcyrrz	95	27	at	at	IN
cord-290677-3gdcyrrz	95	28	the	the	DT
cord-290677-3gdcyrrz	95	29	synaptic	synaptic	JJ
cord-290677-3gdcyrrz	95	30	junction	junction	NN
cord-290677-3gdcyrrz	95	31	with	with	IN
cord-290677-3gdcyrrz	95	32	macrophages	macrophage	NNS
cord-290677-3gdcyrrz	95	33	65	65	CD
cord-290677-3gdcyrrz	95	34	,	,	,
cord-290677-3gdcyrrz	95	35	69	69	CD
cord-290677-3gdcyrrz	95	36	.	.	.
cord-290677-3gdcyrrz	96	1	As	as	IN
cord-290677-3gdcyrrz	96	2	lung	lung	NN
cord-290677-3gdcyrrz	96	3	macrophages	macrophage	NNS
cord-290677-3gdcyrrz	96	4	have	have	VBP
cord-290677-3gdcyrrz	96	5	been	be	VBN
cord-290677-3gdcyrrz	96	6	shown	show	VBN
cord-290677-3gdcyrrz	96	7	to	to	TO
cord-290677-3gdcyrrz	96	8	express	express	VB
cord-290677-3gdcyrrz	96	9	M2	M2	NNP
cord-290677-3gdcyrrz	96	10	and	and	CC
cord-290677-3gdcyrrz	96	11	M3	M3	NNP
cord-290677-3gdcyrrz	96	12	receptors	receptor	NNS
cord-290677-3gdcyrrz	96	13	47	47	CD
cord-290677-3gdcyrrz	96	14	,	,	,
cord-290677-3gdcyrrz	96	15	acetylcholine	acetylcholine	NN
cord-290677-3gdcyrrz	96	16	release	release	NN
cord-290677-3gdcyrrz	96	17	in	in	IN
cord-290677-3gdcyrrz	96	18	the	the	DT
cord-290677-3gdcyrrz	96	19	airways	airway	NNS
cord-290677-3gdcyrrz	96	20	is	be	VBZ
cord-290677-3gdcyrrz	96	21	likely	likely	JJ
cord-290677-3gdcyrrz	96	22	to	to	TO
cord-290677-3gdcyrrz	96	23	contribute	contribute	VB
cord-290677-3gdcyrrz	96	24	to	to	IN
cord-290677-3gdcyrrz	96	25	immune	immune	JJ
cord-290677-3gdcyrrz	96	26	modulation	modulation	NN
cord-290677-3gdcyrrz	96	27	and	and	CC
cord-290677-3gdcyrrz	96	28	cytokine	cytokine	NN
cord-290677-3gdcyrrz	96	29	release	release	NN
cord-290677-3gdcyrrz	96	30	in	in	IN
cord-290677-3gdcyrrz	96	31	the	the	DT
cord-290677-3gdcyrrz	96	32	lung	lung	NN
cord-290677-3gdcyrrz	96	33	microenvironment	microenvironment	NN
cord-290677-3gdcyrrz	96	34	.	.	.
cord-290677-3gdcyrrz	97	1	Nerve	nerve	NN
cord-290677-3gdcyrrz	97	2	-	-	HYPH
cord-290677-3gdcyrrz	97	3	and	and	CC
cord-290677-3gdcyrrz	97	4	airway	airway	NN
cord-290677-3gdcyrrz	97	5	-	-	HYPH
cord-290677-3gdcyrrz	97	6	associated	associate	VBN
cord-290677-3gdcyrrz	97	7	macro	macro	NN
cord-290677-3gdcyrrz	97	8	phages	phage	NNS
cord-290677-3gdcyrrz	97	9	(	(	-LRB-
cord-290677-3gdcyrrz	97	10	NAMs	NAMs	NNP
cord-290677-3gdcyrrz	97	11	)	)	-RRB-
cord-290677-3gdcyrrz	97	12	are	be	VBP
cord-290677-3gdcyrrz	97	13	a	a	DT
cord-290677-3gdcyrrz	97	14	newly	newly	RB
cord-290677-3gdcyrrz	97	15	discovered	discover	VBN
cord-290677-3gdcyrrz	97	16	interstitial	interstitial	JJ
cord-290677-3gdcyrrz	97	17	tissue	tissue	NN
cord-290677-3gdcyrrz	97	18	-	-	HYPH
cord-290677-3gdcyrrz	97	19	resident	resident	NN
cord-290677-3gdcyrrz	97	20	macrophage	macrophage	NN
cord-290677-3gdcyrrz	97	21	subset	subset	VBN
cord-290677-3gdcyrrz	97	22	found	find	VBN
cord-290677-3gdcyrrz	97	23	in	in	IN
cord-290677-3gdcyrrz	97	24	close	close	JJ
cord-290677-3gdcyrrz	97	25	association	association	NN
cord-290677-3gdcyrrz	97	26	with	with	IN
cord-290677-3gdcyrrz	97	27	neuronal	neuronal	JJ
cord-290677-3gdcyrrz	97	28	projections	projection	NNS
cord-290677-3gdcyrrz	97	29	in	in	IN
cord-290677-3gdcyrrz	97	30	the	the	DT
cord-290677-3gdcyrrz	97	31	airways	airways	NNP
cord-290677-3gdcyrrz	97	32	21	21	CD
cord-290677-3gdcyrrz	97	33	.	.	.
cord-290677-3gdcyrrz	98	1	These	these	DT
cord-290677-3gdcyrrz	98	2	cells	cell	NNS
cord-290677-3gdcyrrz	98	3	show	show	VBP
cord-290677-3gdcyrrz	98	4	distinct	distinct	JJ
cord-290677-3gdcyrrz	98	5	transcriptional	transcriptional	JJ
cord-290677-3gdcyrrz	98	6	signatures	signature	NNS
cord-290677-3gdcyrrz	98	7	,	,	,
cord-290677-3gdcyrrz	98	8	including	include	VBG
cord-290677-3gdcyrrz	98	9	CD169	cd169	XX
cord-290677-3gdcyrrz	98	10	+	+	SYM
cord-290677-3gdcyrrz	98	11	CD11c	CD11c	NNP
cord-290677-3gdcyrrz	98	12	−	−	NNP
cord-290677-3gdcyrrz	98	13	and	and	CC
cord-290677-3gdcyrrz	98	14	MHCII	MHCII	NNP
cord-290677-3gdcyrrz	99	1	hi	hi	UH
cord-290677-3gdcyrrz	99	2	,	,	,
cord-290677-3gdcyrrz	99	3	as	as	RB
cord-290677-3gdcyrrz	99	4	well	well	RB
cord-290677-3gdcyrrz	99	5	as	as	IN
cord-290677-3gdcyrrz	99	6	high	high	JJ
cord-290677-3gdcyrrz	99	7	expression	expression	NN
cord-290677-3gdcyrrz	99	8	of	of	IN
cord-290677-3gdcyrrz	99	9	genes	gene	NNS
cord-290677-3gdcyrrz	99	10	involved	involve	VBN
cord-290677-3gdcyrrz	99	11	in	in	IN
cord-290677-3gdcyrrz	99	12	communication	communication	NN
cord-290677-3gdcyrrz	99	13	with	with	IN
cord-290677-3gdcyrrz	99	14	nerve	nerve	NN
cord-290677-3gdcyrrz	99	15	cells	cell	NNS
cord-290677-3gdcyrrz	99	16	,	,	,
cord-290677-3gdcyrrz	99	17	such	such	JJ
cord-290677-3gdcyrrz	99	18	as	as	IN
cord-290677-3gdcyrrz	99	19	C1q	C1q	NNP
cord-290677-3gdcyrrz	99	20	and	and	CC
cord-290677-3gdcyrrz	99	21	CX3CR1	CX3CR1	NNP
cord-290677-3gdcyrrz	99	22	.	.	.
cord-290677-3gdcyrrz	100	1	Ural	Ural	NNP
cord-290677-3gdcyrrz	100	2	et	et	NNP
cord-290677-3gdcyrrz	100	3	al	al	NNP
cord-290677-3gdcyrrz	100	4	.	.	NNP
cord-290677-3gdcyrrz	100	5	showed	show	VBD
cord-290677-3gdcyrrz	100	6	that	that	IN
cord-290677-3gdcyrrz	100	7	NAMs	nam	NNS
cord-290677-3gdcyrrz	100	8	proliferated	proliferate	VBD
cord-290677-3gdcyrrz	100	9	robustly	robustly	RB
cord-290677-3gdcyrrz	100	10	following	follow	VBG
cord-290677-3gdcyrrz	100	11	infection	infection	NN
cord-290677-3gdcyrrz	100	12	with	with	IN
cord-290677-3gdcyrrz	100	13	influenza	influenza	NN
cord-290677-3gdcyrrz	100	14	virus	virus	NN
cord-290677-3gdcyrrz	100	15	in	in	IN
cord-290677-3gdcyrrz	100	16	wild	wild	JJ
cord-290677-3gdcyrrz	100	17	-	-	HYPH
cord-290677-3gdcyrrz	100	18	type	type	NN
cord-290677-3gdcyrrz	100	19	mice	mouse	NNS
cord-290677-3gdcyrrz	100	20	.	.	.
cord-290677-3gdcyrrz	101	1	However	however	RB
cord-290677-3gdcyrrz	101	2	,	,	,
cord-290677-3gdcyrrz	101	3	in	in	IN
cord-290677-3gdcyrrz	101	4	mice	mouse	NNS
cord-290677-3gdcyrrz	101	5	genetically	genetically	RB
cord-290677-3gdcyrrz	101	6	depleted	deplete	VBN
cord-290677-3gdcyrrz	101	7	of	of	IN
cord-290677-3gdcyrrz	101	8	NAMs	nam	NNS
cord-290677-3gdcyrrz	101	9	,	,	,
cord-290677-3gdcyrrz	101	10	infection	infection	NN
cord-290677-3gdcyrrz	101	11	induced	induce	VBD
cord-290677-3gdcyrrz	101	12	an	an	DT
cord-290677-3gdcyrrz	101	13	exaggerated	exaggerated	JJ
cord-290677-3gdcyrrz	101	14	immune	immune	JJ
cord-290677-3gdcyrrz	101	15	response	response	NN
cord-290677-3gdcyrrz	101	16	with	with	IN
cord-290677-3gdcyrrz	101	17	excessive	excessive	JJ
cord-290677-3gdcyrrz	101	18	production	production	NN
cord-290677-3gdcyrrz	101	19	of	of	IN
cord-290677-3gdcyrrz	101	20	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	101	21	cytokines	cytokine	NNS
cord-290677-3gdcyrrz	101	22	and	and	CC
cord-290677-3gdcyrrz	101	23	immune	immune	JJ
cord-290677-3gdcyrrz	101	24	cell	cell	NN
cord-290677-3gdcyrrz	101	25	infiltration	infiltration	NN
cord-290677-3gdcyrrz	101	26	into	into	IN
cord-290677-3gdcyrrz	101	27	tissues	tissue	NNS
cord-290677-3gdcyrrz	101	28	21	21	CD
cord-290677-3gdcyrrz	101	29	.	.	.
cord-290677-3gdcyrrz	102	1	Alveolar	alveolar	JJ
cord-290677-3gdcyrrz	102	2	macrophages	macrophage	NNS
cord-290677-3gdcyrrz	102	3	are	be	VBP
cord-290677-3gdcyrrz	102	4	responsible	responsible	JJ
cord-290677-3gdcyrrz	102	5	for	for	IN
cord-290677-3gdcyrrz	102	6	direct	direct	JJ
cord-290677-3gdcyrrz	102	7	clearance	clearance	NN
cord-290677-3gdcyrrz	102	8	of	of	IN
cord-290677-3gdcyrrz	102	9	viruses	virus	NNS
cord-290677-3gdcyrrz	102	10	,	,	,
cord-290677-3gdcyrrz	102	11	whereas	whereas	IN
cord-290677-3gdcyrrz	102	12	NAMs	nam	NNS
cord-290677-3gdcyrrz	102	13	seem	seem	VBP
cord-290677-3gdcyrrz	102	14	to	to	TO
cord-290677-3gdcyrrz	102	15	be	be	VB
cord-290677-3gdcyrrz	102	16	involved	involve	VBN
cord-290677-3gdcyrrz	102	17	in	in	IN
cord-290677-3gdcyrrz	102	18	moderating	moderate	VBG
cord-290677-3gdcyrrz	102	19	inflammation	inflammation	NN
cord-290677-3gdcyrrz	102	20	in	in	IN
cord-290677-3gdcyrrz	102	21	the	the	DT
cord-290677-3gdcyrrz	102	22	lungs	lung	NNS
cord-290677-3gdcyrrz	102	23	during	during	IN
cord-290677-3gdcyrrz	102	24	viral	viral	JJ
cord-290677-3gdcyrrz	102	25	infection	infection	NN
cord-290677-3gdcyrrz	102	26	,	,	,
cord-290677-3gdcyrrz	102	27	in	in	IN
cord-290677-3gdcyrrz	102	28	part	part	NN
cord-290677-3gdcyrrz	102	29	by	by	IN
cord-290677-3gdcyrrz	102	30	functioning	function	VBG
cord-290677-3gdcyrrz	102	31	as	as	IN
cord-290677-3gdcyrrz	102	32	APCs	apc	NNS
cord-290677-3gdcyrrz	102	33	,	,	,
cord-290677-3gdcyrrz	102	34	in	in	IN
cord-290677-3gdcyrrz	102	35	addition	addition	NN
cord-290677-3gdcyrrz	102	36	to	to	IN
cord-290677-3gdcyrrz	102	37	playing	play	VBG
cord-290677-3gdcyrrz	102	38	a	a	DT
cord-290677-3gdcyrrz	102	39	possible	possible	JJ
cord-290677-3gdcyrrz	102	40	role	role	NN
cord-290677-3gdcyrrz	102	41	in	in	IN
cord-290677-3gdcyrrz	102	42	neuroimmune	neuroimmune	NNP
cord-290677-3gdcyrrz	102	43	communication	communication	NN
cord-290677-3gdcyrrz	102	44	.	.	.
cord-290677-3gdcyrrz	103	1	A	a	DT
cord-290677-3gdcyrrz	103	2	plausible	plausible	JJ
cord-290677-3gdcyrrz	103	3	hypothesis	hypothesis	NN
cord-290677-3gdcyrrz	103	4	is	be	VBZ
cord-290677-3gdcyrrz	103	5	that	that	IN
cord-290677-3gdcyrrz	103	6	these	these	DT
cord-290677-3gdcyrrz	103	7	NAMs	nam	NNS
cord-290677-3gdcyrrz	103	8	act	act	VBP
cord-290677-3gdcyrrz	103	9	in	in	IN
cord-290677-3gdcyrrz	103	10	concert	concert	NN
cord-290677-3gdcyrrz	103	11	with	with	IN
cord-290677-3gdcyrrz	103	12	neuronal	neuronal	JJ
cord-290677-3gdcyrrz	103	13	cells	cell	NNS
cord-290677-3gdcyrrz	103	14	to	to	TO
cord-290677-3gdcyrrz	103	15	control	control	VB
cord-290677-3gdcyrrz	103	16	inflammation	inflammation	NN
cord-290677-3gdcyrrz	103	17	,	,	,
cord-290677-3gdcyrrz	103	18	and	and	CC
cord-290677-3gdcyrrz	103	19	that	that	IN
cord-290677-3gdcyrrz	103	20	malfunctioning	malfunctioning	NN
cord-290677-3gdcyrrz	103	21	of	of	IN
cord-290677-3gdcyrrz	103	22	this	this	DT
cord-290677-3gdcyrrz	103	23	system	system	NN
cord-290677-3gdcyrrz	103	24	in	in	IN
cord-290677-3gdcyrrz	103	25	older	old	JJR
cord-290677-3gdcyrrz	103	26	or	or	CC
cord-290677-3gdcyrrz	103	27	immunocompromised	immunocompromised	JJ
cord-290677-3gdcyrrz	103	28	people	people	NNS
cord-290677-3gdcyrrz	103	29	could	could	MD
cord-290677-3gdcyrrz	103	30	contribute	contribute	VB
cord-290677-3gdcyrrz	103	31	to	to	IN
cord-290677-3gdcyrrz	103	32	the	the	DT
cord-290677-3gdcyrrz	103	33	cytokine	cytokine	NN
cord-290677-3gdcyrrz	103	34	storm	storm	NN
cord-290677-3gdcyrrz	103	35	and	and	CC
cord-290677-3gdcyrrz	103	36	ARDS	ARDS	NNP
cord-290677-3gdcyrrz	103	37	in	in	IN
cord-290677-3gdcyrrz	103	38	patients	patient	NNS
cord-290677-3gdcyrrz	103	39	with	with	IN
cord-290677-3gdcyrrz	103	40	severe	severe	JJ
cord-290677-3gdcyrrz	103	41	COVID-19	covid-19	JJ
cord-290677-3gdcyrrz	103	42	or	or	CC
cord-290677-3gdcyrrz	103	43	other	other	JJ
cord-290677-3gdcyrrz	103	44	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	103	45	virus	virus	NN
cord-290677-3gdcyrrz	103	46	infections	infection	NNS
cord-290677-3gdcyrrz	103	47	.	.	.
cord-290677-3gdcyrrz	104	1	Taken	take	VBN
cord-290677-3gdcyrrz	104	2	together	together	RB
cord-290677-3gdcyrrz	104	3	,	,	,
cord-290677-3gdcyrrz	104	4	the	the	DT
cord-290677-3gdcyrrz	104	5	findings	finding	NNS
cord-290677-3gdcyrrz	104	6	described	describe	VBN
cord-290677-3gdcyrrz	104	7	in	in	IN
cord-290677-3gdcyrrz	104	8	this	this	DT
cord-290677-3gdcyrrz	104	9	section	section	NN
cord-290677-3gdcyrrz	104	10	indicate	indicate	VBP
cord-290677-3gdcyrrz	104	11	that	that	IN
cord-290677-3gdcyrrz	104	12	vagus	vagus	JJ
cord-290677-3gdcyrrz	104	13	nerve	nerve	NN
cord-290677-3gdcyrrz	104	14	activity	activity	NN
cord-290677-3gdcyrrz	104	15	could	could	MD
cord-290677-3gdcyrrz	104	16	modulate	modulate	VB
cord-290677-3gdcyrrz	104	17	systemic	systemic	JJ
cord-290677-3gdcyrrz	104	18	and	and	CC
cord-290677-3gdcyrrz	104	19	local	local	JJ
cord-290677-3gdcyrrz	104	20	inflammation	inflammation	NN
cord-290677-3gdcyrrz	104	21	,	,	,
cord-290677-3gdcyrrz	104	22	probably	probably	RB
cord-290677-3gdcyrrz	104	23	by	by	IN
cord-290677-3gdcyrrz	104	24	acting	act	VBG
cord-290677-3gdcyrrz	104	25	on	on	IN
cord-290677-3gdcyrrz	104	26	tissue	tissue	NN
cord-290677-3gdcyrrz	104	27	-	-	HYPH
cord-290677-3gdcyrrz	104	28	resident	resident	NN
cord-290677-3gdcyrrz	104	29	immune	immune	JJ
cord-290677-3gdcyrrz	104	30	cells	cell	NNS
cord-290677-3gdcyrrz	104	31	,	,	,
cord-290677-3gdcyrrz	104	32	such	such	JJ
cord-290677-3gdcyrrz	104	33	as	as	IN
cord-290677-3gdcyrrz	104	34	NAMs	nam	NNS
cord-290677-3gdcyrrz	104	35	in	in	IN
cord-290677-3gdcyrrz	104	36	the	the	DT
cord-290677-3gdcyrrz	104	37	lungs	lung	NNS
cord-290677-3gdcyrrz	104	38	.	.	.
cord-290677-3gdcyrrz	105	1	We	-PRON-	PRP
cord-290677-3gdcyrrz	105	2	have	have	VBP
cord-290677-3gdcyrrz	105	3	termed	term	VBN
cord-290677-3gdcyrrz	105	4	this	this	DT
cord-290677-3gdcyrrz	105	5	functional	functional	JJ
cord-290677-3gdcyrrz	105	6	association	association	NN
cord-290677-3gdcyrrz	105	7	between	between	IN
cord-290677-3gdcyrrz	105	8	immune	immune	NN
cord-290677-3gdcyrrz	105	9	and	and	CC
cord-290677-3gdcyrrz	105	10	nerve	nerve	NN
cord-290677-3gdcyrrz	105	11	cells	cell	NNS
cord-290677-3gdcyrrz	105	12	the	the	DT
cord-290677-3gdcyrrz	105	13	neuroimmune	neuroimmune	NNP
cord-290677-3gdcyrrz	105	14	unit	unit	NN
cord-290677-3gdcyrrz	105	15	(	(	-LRB-
cord-290677-3gdcyrrz	105	16	NIU	NIU	NNP
cord-290677-3gdcyrrz	105	17	)	)	-RRB-
cord-290677-3gdcyrrz	105	18	,	,	,
cord-290677-3gdcyrrz	105	19	which	which	WDT
cord-290677-3gdcyrrz	105	20	is	be	VBZ
cord-290677-3gdcyrrz	105	21	schematically	schematically	RB
cord-290677-3gdcyrrz	105	22	summarized	summarize	VBN
cord-290677-3gdcyrrz	105	23	in	in	IN
cord-290677-3gdcyrrz	105	24	fig	fig	NN
cord-290677-3gdcyrrz	105	25	.	.	.
cord-290677-3gdcyrrz	106	1	2	2	LS
cord-290677-3gdcyrrz	106	2	.	.	.
cord-290677-3gdcyrrz	107	1	The	the	DT
cord-290677-3gdcyrrz	107	2	morbidity	morbidity	NN
cord-290677-3gdcyrrz	107	3	due	due	IN
cord-290677-3gdcyrrz	107	4	to	to	IN
cord-290677-3gdcyrrz	107	5	infectious	infectious	JJ
cord-290677-3gdcyrrz	107	6	diseases	disease	NNS
cord-290677-3gdcyrrz	107	7	such	such	JJ
cord-290677-3gdcyrrz	107	8	as	as	IN
cord-290677-3gdcyrrz	107	9	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	107	10	syncytial	syncytial	JJ
cord-290677-3gdcyrrz	107	11	virus	virus	NN
cord-290677-3gdcyrrz	107	12	infection	infection	NN
cord-290677-3gdcyrrz	107	13	,	,	,
cord-290677-3gdcyrrz	107	14	viral	viral	JJ
cord-290677-3gdcyrrz	107	15	influenza	influenza	NN
cord-290677-3gdcyrrz	107	16	and	and	CC
cord-290677-3gdcyrrz	107	17	pneumococcal	pneumococcal	JJ
cord-290677-3gdcyrrz	107	18	pneumonia	pneumonia	NN
cord-290677-3gdcyrrz	107	19	is	be	VBZ
cord-290677-3gdcyrrz	107	20	higher	high	JJR
cord-290677-3gdcyrrz	107	21	in	in	IN
cord-290677-3gdcyrrz	107	22	older	old	JJR
cord-290677-3gdcyrrz	107	23	individuals	individual	NNS
cord-290677-3gdcyrrz	107	24	than	than	IN
cord-290677-3gdcyrrz	107	25	in	in	IN
cord-290677-3gdcyrrz	107	26	the	the	DT
cord-290677-3gdcyrrz	107	27	younger	young	JJR
cord-290677-3gdcyrrz	107	28	population	population	NN
cord-290677-3gdcyrrz	107	29	,	,	,
cord-290677-3gdcyrrz	107	30	suggesting	suggest	VBG
cord-290677-3gdcyrrz	107	31	that	that	IN
cord-290677-3gdcyrrz	107	32	the	the	DT
cord-290677-3gdcyrrz	107	33	ability	ability	NN
cord-290677-3gdcyrrz	107	34	to	to	TO
cord-290677-3gdcyrrz	107	35	resist	resist	VB
cord-290677-3gdcyrrz	107	36	infectious	infectious	JJ
cord-290677-3gdcyrrz	107	37	diseases	disease	NNS
cord-290677-3gdcyrrz	107	38	and	and	CC
cord-290677-3gdcyrrz	107	39	mount	mount	VB
cord-290677-3gdcyrrz	107	40	protective	protective	JJ
cord-290677-3gdcyrrz	107	41	immune	immune	JJ
cord-290677-3gdcyrrz	107	42	responses	response	NNS
cord-290677-3gdcyrrz	107	43	declines	decline	VBZ
cord-290677-3gdcyrrz	107	44	with	with	IN
cord-290677-3gdcyrrz	107	45	age	age	NN
cord-290677-3gdcyrrz	107	46	70	70	CD
cord-290677-3gdcyrrz	107	47	.	.	.
cord-290677-3gdcyrrz	108	1	In	in	IN
cord-290677-3gdcyrrz	108	2	addition	addition	NN
cord-290677-3gdcyrrz	108	3	,	,	,
cord-290677-3gdcyrrz	108	4	ageing	age	VBG
cord-290677-3gdcyrrz	108	5	is	be	VBZ
cord-290677-3gdcyrrz	108	6	associated	associate	VBN
cord-290677-3gdcyrrz	108	7	with	with	IN
cord-290677-3gdcyrrz	108	8	enhanced	enhanced	JJ
cord-290677-3gdcyrrz	108	9	homeostatic	homeostatic	JJ
cord-290677-3gdcyrrz	108	10	activation	activation	NN
cord-290677-3gdcyrrz	108	11	of	of	IN
cord-290677-3gdcyrrz	108	12	the	the	DT
cord-290677-3gdcyrrz	108	13	innate	innate	JJ
cord-290677-3gdcyrrz	108	14	immune	immune	JJ
cord-290677-3gdcyrrz	108	15	system	system	NN
cord-290677-3gdcyrrz	108	16	,	,	,
cord-290677-3gdcyrrz	108	17	marked	mark	VBN
cord-290677-3gdcyrrz	108	18	by	by	IN
cord-290677-3gdcyrrz	108	19	elevated	elevated	JJ
cord-290677-3gdcyrrz	108	20	levels	level	NNS
cord-290677-3gdcyrrz	108	21	of	of	IN
cord-290677-3gdcyrrz	108	22	tissue	tissue	NN
cord-290677-3gdcyrrz	108	23	and	and	CC
cord-290677-3gdcyrrz	108	24	circulating	circulate	VBG
cord-290677-3gdcyrrz	108	25	pro	pro	JJ
cord-290677-3gdcyrrz	108	26	-	-	JJ
cord-290677-3gdcyrrz	108	27	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	108	28	cytokines	cytokine	NNS
cord-290677-3gdcyrrz	108	29	such	such	JJ
cord-290677-3gdcyrrz	108	30	as	as	IN
cord-290677-3gdcyrrz	108	31	IFNγ	IFNγ	NNS
cord-290677-3gdcyrrz	108	32	,	,	,
cord-290677-3gdcyrrz	108	33	IL-1β	IL-1β	NNP
cord-290677-3gdcyrrz	108	34	,	,	,
cord-290677-3gdcyrrz	108	35	IL-6	IL-6	NNP
cord-290677-3gdcyrrz	108	36	and	and	CC
cord-290677-3gdcyrrz	108	37	TNF	TNF	NNP
cord-290677-3gdcyrrz	108	38	71	71	CD
cord-290677-3gdcyrrz	108	39	surveillance	surveillance	NN
cord-290677-3gdcyrrz	108	40	as	as	RB
cord-290677-3gdcyrrz	108	41	well	well	RB
cord-290677-3gdcyrrz	108	42	as	as	IN
cord-290677-3gdcyrrz	108	43	an	an	DT
cord-290677-3gdcyrrz	108	44	increase	increase	NN
cord-290677-3gdcyrrz	108	45	in	in	IN
cord-290677-3gdcyrrz	108	46	the	the	DT
cord-290677-3gdcyrrz	108	47	production	production	NN
cord-290677-3gdcyrrz	108	48	of	of	IN
cord-290677-3gdcyrrz	108	49	pro	pro	JJ
cord-290677-3gdcyrrz	108	50	-	-	JJ
cord-290677-3gdcyrrz	108	51	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	108	52	cytokines	cytokine	NNS
cord-290677-3gdcyrrz	108	53	.	.	.
cord-290677-3gdcyrrz	109	1	Following	follow	VBG
cord-290677-3gdcyrrz	109	2	viral	viral	JJ
cord-290677-3gdcyrrz	109	3	infection	infection	NN
cord-290677-3gdcyrrz	109	4	,	,	,
cord-290677-3gdcyrrz	109	5	these	these	DT
cord-290677-3gdcyrrz	109	6	cytokines	cytokine	NNS
cord-290677-3gdcyrrz	109	7	are	be	VBP
cord-290677-3gdcyrrz	109	8	further	further	RB
cord-290677-3gdcyrrz	109	9	produced	produce	VBN
cord-290677-3gdcyrrz	109	10	locally	locally	RB
cord-290677-3gdcyrrz	109	11	by	by	IN
cord-290677-3gdcyrrz	109	12	immune	immune	JJ
cord-290677-3gdcyrrz	109	13	cells	cell	NNS
cord-290677-3gdcyrrz	109	14	,	,	,
cord-290677-3gdcyrrz	109	15	but	but	CC
cord-290677-3gdcyrrz	109	16	their	-PRON-	PRP$
cord-290677-3gdcyrrz	109	17	levels	level	NNS
cord-290677-3gdcyrrz	109	18	are	be	VBP
cord-290677-3gdcyrrz	109	19	potentially	potentially	RB
cord-290677-3gdcyrrz	109	20	reduced	reduce	VBN
cord-290677-3gdcyrrz	109	21	by	by	IN
cord-290677-3gdcyrrz	109	22	vagus	vagus	JJ
cord-290677-3gdcyrrz	109	23	nerve	nerve	NN
cord-290677-3gdcyrrz	109	24	activity	activity	NN
cord-290677-3gdcyrrz	109	25	,	,	,
cord-290677-3gdcyrrz	109	26	leading	lead	VBG
cord-290677-3gdcyrrz	109	27	to	to	IN
cord-290677-3gdcyrrz	109	28	resolution	resolution	NN
cord-290677-3gdcyrrz	109	29	of	of	IN
cord-290677-3gdcyrrz	109	30	inflammation	inflammation	NN
cord-290677-3gdcyrrz	109	31	.	.	.
cord-290677-3gdcyrrz	110	1	With	with	IN
cord-290677-3gdcyrrz	110	2	ageing	age	VBG
cord-290677-3gdcyrrz	110	3	,	,	,
cord-290677-3gdcyrrz	110	4	decreases	decrease	NNS
cord-290677-3gdcyrrz	110	5	in	in	IN
cord-290677-3gdcyrrz	110	6	vagal	vagal	JJ
cord-290677-3gdcyrrz	110	7	immunomodulatory	immunomodulatory	JJ
cord-290677-3gdcyrrz	110	8	function	function	NN
cord-290677-3gdcyrrz	110	9	and	and	CC
cord-290677-3gdcyrrz	110	10	the	the	DT
cord-290677-3gdcyrrz	110	11	immune	immune	JJ
cord-290677-3gdcyrrz	110	12	cell	cell	NN
cord-290677-3gdcyrrz	110	13	response	response	NN
cord-290677-3gdcyrrz	110	14	to	to	IN
cord-290677-3gdcyrrz	110	15	pathogens	pathogen	NNS
cord-290677-3gdcyrrz	110	16	,	,	,
cord-290677-3gdcyrrz	110	17	combined	combine	VBN
cord-290677-3gdcyrrz	110	18	with	with	IN
cord-290677-3gdcyrrz	110	19	increased	increase	VBN
cord-290677-3gdcyrrz	110	20	levels	level	NNS
cord-290677-3gdcyrrz	110	21	of	of	IN
cord-290677-3gdcyrrz	110	22	pro	pro	JJ
cord-290677-3gdcyrrz	110	23	-	-	JJ
cord-290677-3gdcyrrz	110	24	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	110	25	cytokines	cytokine	NNS
cord-290677-3gdcyrrz	110	26	,	,	,
cord-290677-3gdcyrrz	110	27	could	could	MD
cord-290677-3gdcyrrz	110	28	contribute	contribute	VB
cord-290677-3gdcyrrz	110	29	to	to	IN
cord-290677-3gdcyrrz	110	30	the	the	DT
cord-290677-3gdcyrrz	110	31	induction	induction	NN
cord-290677-3gdcyrrz	110	32	of	of	IN
cord-290677-3gdcyrrz	110	33	a	a	DT
cord-290677-3gdcyrrz	110	34	cytokine	cytokine	NN
cord-290677-3gdcyrrz	110	35	storm	storm	NN
cord-290677-3gdcyrrz	110	36	,	,	,
cord-290677-3gdcyrrz	110	37	leading	lead	VBG
cord-290677-3gdcyrrz	110	38	to	to	IN
cord-290677-3gdcyrrz	110	39	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	110	40	failure	failure	NN
cord-290677-3gdcyrrz	110	41	and	and	CC
cord-290677-3gdcyrrz	110	42	death	death	NN
cord-290677-3gdcyrrz	110	43	.	.	.
cord-290677-3gdcyrrz	111	1	mAChR	mAChR	NNP
cord-290677-3gdcyrrz	111	2	,	,	,
cord-290677-3gdcyrrz	111	3	muscarinic	muscarinic	NNP
cord-290677-3gdcyrrz	111	4	ACh	ACh	NNP
cord-290677-3gdcyrrz	111	5	receptor	receptor	NN
cord-290677-3gdcyrrz	111	6	;	;	:
cord-290677-3gdcyrrz	111	7	TNF	TNF	NNP
cord-290677-3gdcyrrz	111	8	,	,	,
cord-290677-3gdcyrrz	111	9	tumour	tumour	NN
cord-290677-3gdcyrrz	111	10	necrosis	necrosis	NN
cord-290677-3gdcyrrz	111	11	factor	factor	NN
cord-290677-3gdcyrrz	111	12	.	.	.
cord-290677-3gdcyrrz	112	1	www.nature.com/nrneurol	www.nature.com/nrneurol	JJ
cord-290677-3gdcyrrz	113	1	resulting	result	VBG
cord-290677-3gdcyrrz	113	2	in	in	IN
cord-290677-3gdcyrrz	113	3	macrophages	macrophage	NNS
cord-290677-3gdcyrrz	113	4	with	with	IN
cord-290677-3gdcyrrz	113	5	reduced	reduce	VBN
cord-290677-3gdcyrrz	113	6	phagocytosis	phagocytosis	NN
cord-290677-3gdcyrrz	113	7	and	and	CC
cord-290677-3gdcyrrz	113	8	nitrite	nitrite	NN
cord-290677-3gdcyrrz	113	9	burst	burst	NN
cord-290677-3gdcyrrz	113	10	activity	activity	NN
cord-290677-3gdcyrrz	113	11	in	in	IN
cord-290677-3gdcyrrz	113	12	the	the	DT
cord-290677-3gdcyrrz	113	13	presence	presence	NN
cord-290677-3gdcyrrz	113	14	of	of	IN
cord-290677-3gdcyrrz	113	15	a	a	DT
cord-290677-3gdcyrrz	113	16	markedly	markedly	RB
cord-290677-3gdcyrrz	113	17	increased	increase	VBN
cord-290677-3gdcyrrz	113	18	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	113	19	cytokine	cytokine	NN
cord-290677-3gdcyrrz	113	20	response	response	NN
cord-290677-3gdcyrrz	113	21	72	72	CD
cord-290677-3gdcyrrz	113	22	.	.	.
cord-290677-3gdcyrrz	114	1	Modulation	modulation	NN
cord-290677-3gdcyrrz	114	2	of	of	IN
cord-290677-3gdcyrrz	114	3	autophagy	autophagy	NN
cord-290677-3gdcyrrz	114	4	might	may	MD
cord-290677-3gdcyrrz	114	5	preserve	preserve	VB
cord-290677-3gdcyrrz	114	6	macrophage	macrophage	NN
cord-290677-3gdcyrrz	114	7	function	function	NN
cord-290677-3gdcyrrz	114	8	during	during	IN
cord-290677-3gdcyrrz	114	9	ageing	age	VBG
cord-290677-3gdcyrrz	114	10	,	,	,
cord-290677-3gdcyrrz	114	11	therefore	therefore	RB
cord-290677-3gdcyrrz	114	12	reducing	reduce	VBG
cord-290677-3gdcyrrz	114	13	the	the	DT
cord-290677-3gdcyrrz	114	14	morbidity	morbidity	NN
cord-290677-3gdcyrrz	114	15	and	and	CC
cord-290677-3gdcyrrz	114	16	mortality	mortality	NN
cord-290677-3gdcyrrz	114	17	associated	associate	VBN
cord-290677-3gdcyrrz	114	18	with	with	IN
cord-290677-3gdcyrrz	114	19	inflammageing	inflammagee	VBG
cord-290677-3gdcyrrz	114	20	73	73	CD
cord-290677-3gdcyrrz	114	21	.	.	.
cord-290677-3gdcyrrz	115	1	The	the	DT
cord-290677-3gdcyrrz	115	2	term	term	NN
cord-290677-3gdcyrrz	115	3	'	'	``
cord-290677-3gdcyrrz	115	4	immunosenescence	immunosenescence	NN
cord-290677-3gdcyrrz	115	5	'	'	''
cord-290677-3gdcyrrz	115	6	refers	refer	VBZ
cord-290677-3gdcyrrz	115	7	to	to	IN
cord-290677-3gdcyrrz	115	8	the	the	DT
cord-290677-3gdcyrrz	115	9	functional	functional	JJ
cord-290677-3gdcyrrz	115	10	decay	decay	NN
cord-290677-3gdcyrrz	115	11	of	of	IN
cord-290677-3gdcyrrz	115	12	immunity	immunity	NN
cord-290677-3gdcyrrz	115	13	with	with	IN
cord-290677-3gdcyrrz	115	14	age	age	NN
cord-290677-3gdcyrrz	115	15	,	,	,
cord-290677-3gdcyrrz	115	16	with	with	IN
cord-290677-3gdcyrrz	115	17	thymic	thymic	JJ
cord-290677-3gdcyrrz	115	18	involution	involution	NN
cord-290677-3gdcyrrz	115	19	being	be	VBG
cord-290677-3gdcyrrz	115	20	an	an	DT
cord-290677-3gdcyrrz	115	21	early	early	JJ
cord-290677-3gdcyrrz	115	22	sign	sign	NN
cord-290677-3gdcyrrz	115	23	.	.	.
cord-290677-3gdcyrrz	116	1	The	the	DT
cord-290677-3gdcyrrz	116	2	hallmarks	hallmark	NNS
cord-290677-3gdcyrrz	116	3	of	of	IN
cord-290677-3gdcyrrz	116	4	immunosenescence	immunosenescence	NN
cord-290677-3gdcyrrz	116	5	include	include	VB
cord-290677-3gdcyrrz	116	6	an	an	DT
cord-290677-3gdcyrrz	116	7	inverted	inverted	JJ
cord-290677-3gdcyrrz	116	8	CD4	CD4	NNP
cord-290677-3gdcyrrz	116	9	to	to	IN
cord-290677-3gdcyrrz	116	10	CD8	CD8	NNP
cord-290677-3gdcyrrz	116	11	ratio	ratio	NN
cord-290677-3gdcyrrz	116	12	,	,	,
cord-290677-3gdcyrrz	116	13	loss	loss	NN
cord-290677-3gdcyrrz	116	14	of	of	IN
cord-290677-3gdcyrrz	116	15	naive	naive	JJ
cord-290677-3gdcyrrz	116	16	T	t	NN
cord-290677-3gdcyrrz	116	17	cells	cell	NNS
cord-290677-3gdcyrrz	116	18	,	,	,
cord-290677-3gdcyrrz	116	19	increased	increase	VBD
cord-290677-3gdcyrrz	116	20	numbers	number	NNS
cord-290677-3gdcyrrz	116	21	of	of	IN
cord-290677-3gdcyrrz	116	22	terminally	terminally	RB
cord-290677-3gdcyrrz	116	23	differentiated	differentiate	VBN
cord-290677-3gdcyrrz	116	24	T	t	NN
cord-290677-3gdcyrrz	116	25	cells	cell	NNS
cord-290677-3gdcyrrz	116	26	and	and	CC
cord-290677-3gdcyrrz	116	27	oligoclonal	oligoclonal	JJ
cord-290677-3gdcyrrz	116	28	expansion	expansion	NN
cord-290677-3gdcyrrz	116	29	of	of	IN
cord-290677-3gdcyrrz	116	30	virus	virus	NN
cord-290677-3gdcyrrz	116	31	-	-	HYPH
cord-290677-3gdcyrrz	116	32	specific	specific	JJ
cord-290677-3gdcyrrz	116	33	T	t	NN
cord-290677-3gdcyrrz	116	34	cells	cell	NNS
cord-290677-3gdcyrrz	116	35	38	38	CD
cord-290677-3gdcyrrz	116	36	,	,	,
cord-290677-3gdcyrrz	116	37	74	74	CD
cord-290677-3gdcyrrz	116	38	.	.	.
cord-290677-3gdcyrrz	117	1	The	the	DT
cord-290677-3gdcyrrz	117	2	activation	activation	NN
cord-290677-3gdcyrrz	117	3	of	of	IN
cord-290677-3gdcyrrz	117	4	natural	natural	JJ
cord-290677-3gdcyrrz	117	5	killer	killer	NN
cord-290677-3gdcyrrz	117	6	(	(	-LRB-
cord-290677-3gdcyrrz	117	7	NK	NK	NNP
cord-290677-3gdcyrrz	117	8	)	)	-RRB-
cord-290677-3gdcyrrz	117	9	cells	cell	NNS
cord-290677-3gdcyrrz	117	10	is	be	VBZ
cord-290677-3gdcyrrz	117	11	substantially	substantially	RB
cord-290677-3gdcyrrz	117	12	enhanced	enhance	VBN
cord-290677-3gdcyrrz	117	13	in	in	IN
cord-290677-3gdcyrrz	117	14	older	old	JJR
cord-290677-3gdcyrrz	117	15	individuals	individual	NNS
cord-290677-3gdcyrrz	117	16	75	75	CD
cord-290677-3gdcyrrz	117	17	,	,	,
cord-290677-3gdcyrrz	117	18	and	and	CC
cord-290677-3gdcyrrz	117	19	latent	latent	JJ
cord-290677-3gdcyrrz	117	20	cytomegalovirus	cytomegalovirus	JJ
cord-290677-3gdcyrrz	117	21	infection	infection	NN
cord-290677-3gdcyrrz	117	22	has	have	VBZ
cord-290677-3gdcyrrz	117	23	been	be	VBN
cord-290677-3gdcyrrz	117	24	shown	show	VBN
cord-290677-3gdcyrrz	117	25	to	to	TO
cord-290677-3gdcyrrz	117	26	contribute	contribute	VB
cord-290677-3gdcyrrz	117	27	to	to	IN
cord-290677-3gdcyrrz	117	28	the	the	DT
cord-290677-3gdcyrrz	117	29	immunosenescence	immunosenescence	NN
cord-290677-3gdcyrrz	117	30	of	of	IN
cord-290677-3gdcyrrz	117	31	T	T	NNP
cord-290677-3gdcyrrz	117	32	and	and	CC
cord-290677-3gdcyrrz	117	33	NK	NK	NNP
cord-290677-3gdcyrrz	117	34	cells	cell	VBZ
cord-290677-3gdcyrrz	117	35	76	76	CD
cord-290677-3gdcyrrz	117	36	,	,	,
cord-290677-3gdcyrrz	117	37	77	77	CD
cord-290677-3gdcyrrz	117	38	.	.	.
cord-290677-3gdcyrrz	118	1	Importantly	importantly	RB
cord-290677-3gdcyrrz	118	2	,	,	,
cord-290677-3gdcyrrz	118	3	senescent	senescent	JJ
cord-290677-3gdcyrrz	118	4	CD8	CD8	NNP
cord-290677-3gdcyrrz	118	5	+	+	CC
cord-290677-3gdcyrrz	118	6	CD28	CD28	NNP
cord-290677-3gdcyrrz	118	7	−	−	NNP
cord-290677-3gdcyrrz	119	1	effector	effector	NNP
cord-290677-3gdcyrrz	119	2	T	T	NNP
cord-290677-3gdcyrrz	119	3	cells	cell	NNS
cord-290677-3gdcyrrz	119	4	lack	lack	VBP
cord-290677-3gdcyrrz	119	5	perforin	perforin	NNP
cord-290677-3gdcyrrz	119	6	,	,	,
cord-290677-3gdcyrrz	119	7	rendering	render	VBG
cord-290677-3gdcyrrz	119	8	them	-PRON-	PRP
cord-290677-3gdcyrrz	119	9	inefficient	inefficient	JJ
cord-290677-3gdcyrrz	119	10	as	as	IN
cord-290677-3gdcyrrz	119	11	antigen	antigen	NN
cord-290677-3gdcyrrz	119	12	-	-	HYPH
cord-290677-3gdcyrrz	119	13	specific	specific	JJ
cord-290677-3gdcyrrz	119	14	killers	killer	NNS
cord-290677-3gdcyrrz	119	15	during	during	IN
cord-290677-3gdcyrrz	119	16	viral	viral	JJ
cord-290677-3gdcyrrz	119	17	infection	infection	NN
cord-290677-3gdcyrrz	119	18	78	78	CD
cord-290677-3gdcyrrz	119	19	,	,	,
cord-290677-3gdcyrrz	119	20	79	79	CD
cord-290677-3gdcyrrz	119	21	.	.	.
cord-290677-3gdcyrrz	120	1	However	however	RB
cord-290677-3gdcyrrz	120	2	,	,	,
cord-290677-3gdcyrrz	120	3	in	in	IN
cord-290677-3gdcyrrz	120	4	certain	certain	JJ
cord-290677-3gdcyrrz	120	5	diseases	disease	NNS
cord-290677-3gdcyrrz	120	6	such	such	JJ
cord-290677-3gdcyrrz	120	7	as	as	IN
cord-290677-3gdcyrrz	120	8	COPD	COPD	NNP
cord-290677-3gdcyrrz	120	9	and	and	CC
cord-290677-3gdcyrrz	120	10	rheumatoid	rheumatoid	NN
cord-290677-3gdcyrrz	120	11	arthritis	arthritis	NN
cord-290677-3gdcyrrz	120	12	,	,	.
cord-290677-3gdcyrrz	121	1	CD8	CD8	NNP
cord-290677-3gdcyrrz	121	2	+	+	SYM
cord-290677-3gdcyrrz	121	3	CD28	CD28	NNP
cord-290677-3gdcyrrz	121	4	−	−	NNP
cord-290677-3gdcyrrz	121	5	cells	cell	NNS
cord-290677-3gdcyrrz	121	6	have	have	VBP
cord-290677-3gdcyrrz	121	7	been	be	VBN
cord-290677-3gdcyrrz	121	8	reported	report	VBN
cord-290677-3gdcyrrz	121	9	to	to	TO
cord-290677-3gdcyrrz	121	10	express	express	VB
cord-290677-3gdcyrrz	121	11	increased	increased	JJ
cord-290677-3gdcyrrz	121	12	levels	level	NNS
cord-290677-3gdcyrrz	121	13	of	of	IN
cord-290677-3gdcyrrz	121	14	the	the	DT
cord-290677-3gdcyrrz	121	15	cytotoxic	cytotoxic	JJ
cord-290677-3gdcyrrz	121	16	mediators	mediator	NNS
cord-290677-3gdcyrrz	121	17	perforin	perforin	NNS
cord-290677-3gdcyrrz	121	18	and	and	CC
cord-290677-3gdcyrrz	121	19	granzyme	granzyme	NNP
cord-290677-3gdcyrrz	121	20	B	B	NNP
cord-290677-3gdcyrrz	121	21	and	and	CC
cord-290677-3gdcyrrz	121	22	the	the	DT
cord-290677-3gdcyrrz	121	23	pro	pro	JJ
cord-290677-3gdcyrrz	121	24	-	-	JJ
cord-290677-3gdcyrrz	121	25	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	121	26	cytokines	cytokine	NNS
cord-290677-3gdcyrrz	121	27	IFNγ	IFNγ	NNS
cord-290677-3gdcyrrz	121	28	and	and	CC
cord-290677-3gdcyrrz	121	29	TNF	TNF	NNP
cord-290677-3gdcyrrz	121	30	,	,	,
cord-290677-3gdcyrrz	121	31	and	and	CC
cord-290677-3gdcyrrz	121	32	can	can	MD
cord-290677-3gdcyrrz	121	33	cause	cause	VB
cord-290677-3gdcyrrz	121	34	substantial	substantial	JJ
cord-290677-3gdcyrrz	121	35	tissue	tissue	NN
cord-290677-3gdcyrrz	121	36	damage	damage	NN
cord-290677-3gdcyrrz	121	37	in	in	IN
cord-290677-3gdcyrrz	121	38	an	an	DT
cord-290677-3gdcyrrz	121	39	antigen	antigen	NN
cord-290677-3gdcyrrz	121	40	non	non	JJ
cord-290677-3gdcyrrz	121	41	-	-	JJ
cord-290677-3gdcyrrz	121	42	specific	specific	JJ
cord-290677-3gdcyrrz	121	43	manner	manner	NN
cord-290677-3gdcyrrz	121	44	80	80	CD
cord-290677-3gdcyrrz	121	45	.	.	.
cord-290677-3gdcyrrz	122	1	Ageing	age	VBG
cord-290677-3gdcyrrz	122	2	is	be	VBZ
cord-290677-3gdcyrrz	122	3	also	also	RB
cord-290677-3gdcyrrz	122	4	associated	associate	VBN
cord-290677-3gdcyrrz	122	5	with	with	IN
cord-290677-3gdcyrrz	122	6	changes	change	NNS
cord-290677-3gdcyrrz	122	7	in	in	IN
cord-290677-3gdcyrrz	122	8	autonomic	autonomic	JJ
cord-290677-3gdcyrrz	122	9	nervous	nervous	JJ
cord-290677-3gdcyrrz	122	10	system	system	NN
cord-290677-3gdcyrrz	122	11	function	function	NN
cord-290677-3gdcyrrz	122	12	,	,	,
cord-290677-3gdcyrrz	122	13	characterized	characterize	VBN
cord-290677-3gdcyrrz	122	14	by	by	IN
cord-290677-3gdcyrrz	122	15	increases	increase	NNS
cord-290677-3gdcyrrz	122	16	in	in	IN
cord-290677-3gdcyrrz	122	17	sympathetic	sympathetic	JJ
cord-290677-3gdcyrrz	122	18	and	and	CC
cord-290677-3gdcyrrz	122	19	decreases	decrease	VBZ
cord-290677-3gdcyrrz	122	20	in	in	IN
cord-290677-3gdcyrrz	122	21	parasympathetic	parasympathetic	JJ
cord-290677-3gdcyrrz	122	22	nervous	nervous	JJ
cord-290677-3gdcyrrz	122	23	activity	activity	NN
cord-290677-3gdcyrrz	122	24	81	81	CD
cord-290677-3gdcyrrz	122	25	,	,	,
cord-290677-3gdcyrrz	122	26	82	82	CD
cord-290677-3gdcyrrz	122	27	.	.	.
cord-290677-3gdcyrrz	123	1	A	a	DT
cord-290677-3gdcyrrz	123	2	study	study	NN
cord-290677-3gdcyrrz	123	3	of	of	IN
cord-290677-3gdcyrrz	123	4	heart	heart	NN
cord-290677-3gdcyrrz	123	5	physiology	physiology	NN
cord-290677-3gdcyrrz	123	6	showed	show	VBD
cord-290677-3gdcyrrz	123	7	that	that	IN
cord-290677-3gdcyrrz	123	8	vagal	vagal	JJ
cord-290677-3gdcyrrz	123	9	control	control	NN
cord-290677-3gdcyrrz	123	10	of	of	IN
cord-290677-3gdcyrrz	123	11	heart	heart	NN
cord-290677-3gdcyrrz	123	12	rate	rate	NN
cord-290677-3gdcyrrz	123	13	and	and	CC
cord-290677-3gdcyrrz	123	14	the	the	DT
cord-290677-3gdcyrrz	123	15	response	response	NN
cord-290677-3gdcyrrz	123	16	of	of	IN
cord-290677-3gdcyrrz	123	17	the	the	DT
cord-290677-3gdcyrrz	123	18	vagus	vagus	NN
cord-290677-3gdcyrrz	123	19	nerve	nerve	NN
cord-290677-3gdcyrrz	123	20	to	to	IN
cord-290677-3gdcyrrz	123	21	stimulation	stimulation	NN
cord-290677-3gdcyrrz	123	22	decrease	decrease	NN
cord-290677-3gdcyrrz	123	23	with	with	IN
cord-290677-3gdcyrrz	123	24	age	age	NN
cord-290677-3gdcyrrz	123	25	83	83	CD
cord-290677-3gdcyrrz	123	26	.	.	.
cord-290677-3gdcyrrz	124	1	Furthermore	furthermore	RB
cord-290677-3gdcyrrz	124	2	,	,	,
cord-290677-3gdcyrrz	124	3	the	the	DT
cord-290677-3gdcyrrz	124	4	responsiveness	responsiveness	NN
cord-290677-3gdcyrrz	124	5	of	of	IN
cord-290677-3gdcyrrz	124	6	muscarinic	muscarinic	JJ
cord-290677-3gdcyrrz	124	7	receptors	receptor	NNS
cord-290677-3gdcyrrz	124	8	in	in	IN
cord-290677-3gdcyrrz	124	9	the	the	DT
cord-290677-3gdcyrrz	124	10	heart	heart	NN
cord-290677-3gdcyrrz	124	11	,	,	,
cord-290677-3gdcyrrz	124	12	but	but	CC
cord-290677-3gdcyrrz	124	13	not	not	RB
cord-290677-3gdcyrrz	124	14	in	in	IN
cord-290677-3gdcyrrz	124	15	the	the	DT
cord-290677-3gdcyrrz	124	16	peripheral	peripheral	JJ
cord-290677-3gdcyrrz	124	17	vasculature	vasculature	NN
cord-290677-3gdcyrrz	124	18	,	,	,
cord-290677-3gdcyrrz	124	19	was	be	VBD
cord-290677-3gdcyrrz	124	20	shown	show	VBN
cord-290677-3gdcyrrz	124	21	to	to	TO
cord-290677-3gdcyrrz	124	22	decline	decline	VB
cord-290677-3gdcyrrz	124	23	with	with	IN
cord-290677-3gdcyrrz	124	24	age	age	NN
cord-290677-3gdcyrrz	124	25	83	83	CD
cord-290677-3gdcyrrz	124	26	.	.	.
cord-290677-3gdcyrrz	125	1	In	in	IN
cord-290677-3gdcyrrz	125	2	line	line	NN
cord-290677-3gdcyrrz	125	3	with	with	IN
cord-290677-3gdcyrrz	125	4	these	these	DT
cord-290677-3gdcyrrz	125	5	findings	finding	NNS
cord-290677-3gdcyrrz	125	6	,	,	,
cord-290677-3gdcyrrz	125	7	vagus	vagus	JJ
cord-290677-3gdcyrrz	125	8	nerve	nerve	NN
cord-290677-3gdcyrrz	125	9	stimulation	stimulation	NN
cord-290677-3gdcyrrz	125	10	(	(	-LRB-
cord-290677-3gdcyrrz	125	11	VNS	VNS	NNP
cord-290677-3gdcyrrz	125	12	)	)	-RRB-
cord-290677-3gdcyrrz	125	13	can	can	MD
cord-290677-3gdcyrrz	125	14	ameliorate	ameliorate	VB
cord-290677-3gdcyrrz	125	15	age	age	NN
cord-290677-3gdcyrrz	125	16	-	-	HYPH
cord-290677-3gdcyrrz	125	17	related	relate	VBN
cord-290677-3gdcyrrz	125	18	alterations	alteration	NNS
cord-290677-3gdcyrrz	125	19	in	in	IN
cord-290677-3gdcyrrz	125	20	the	the	DT
cord-290677-3gdcyrrz	125	21	cardiac	cardiac	JJ
cord-290677-3gdcyrrz	125	22	baroreflex	baroreflex	NN
cord-290677-3gdcyrrz	125	23	,	,	,
cord-290677-3gdcyrrz	125	24	heart	heart	NN
cord-290677-3gdcyrrz	125	25	rate	rate	NN
cord-290677-3gdcyrrz	125	26	and	and	CC
cord-290677-3gdcyrrz	125	27	autonomic	autonomic	JJ
cord-290677-3gdcyrrz	125	28	responses	response	NNS
cord-290677-3gdcyrrz	125	29	,	,	,
cord-290677-3gdcyrrz	125	30	and	and	CC
cord-290677-3gdcyrrz	125	31	is	be	VBZ
cord-290677-3gdcyrrz	125	32	associated	associate	VBN
cord-290677-3gdcyrrz	125	33	with	with	IN
cord-290677-3gdcyrrz	125	34	improved	improved	JJ
cord-290677-3gdcyrrz	125	35	cardiopulmonary	cardiopulmonary	JJ
cord-290677-3gdcyrrz	125	36	outcomes	outcome	NNS
cord-290677-3gdcyrrz	125	37	84	84	CD
cord-290677-3gdcyrrz	125	38	,	,	,
cord-290677-3gdcyrrz	125	39	85	85	CD
cord-290677-3gdcyrrz	125	40	.	.	.
cord-290677-3gdcyrrz	126	1	Ageing	age	VBG
cord-290677-3gdcyrrz	126	2	is	be	VBZ
cord-290677-3gdcyrrz	126	3	associated	associate	VBN
cord-290677-3gdcyrrz	126	4	with	with	IN
cord-290677-3gdcyrrz	126	5	alterations	alteration	NNS
cord-290677-3gdcyrrz	126	6	in	in	IN
cord-290677-3gdcyrrz	126	7	neuronal	neuronal	JJ
cord-290677-3gdcyrrz	126	8	activity	activity	NN
cord-290677-3gdcyrrz	126	9	in	in	IN
cord-290677-3gdcyrrz	126	10	multiple	multiple	JJ
cord-290677-3gdcyrrz	126	11	systems	system	NNS
cord-290677-3gdcyrrz	126	12	,	,	,
cord-290677-3gdcyrrz	126	13	and	and	CC
cord-290677-3gdcyrrz	126	14	changes	change	NNS
cord-290677-3gdcyrrz	126	15	in	in	IN
cord-290677-3gdcyrrz	126	16	neuropeptide	neuropeptide	NN
cord-290677-3gdcyrrz	126	17	release	release	NN
cord-290677-3gdcyrrz	126	18	in	in	IN
cord-290677-3gdcyrrz	126	19	the	the	DT
cord-290677-3gdcyrrz	126	20	lung	lung	NN
cord-290677-3gdcyrrz	126	21	mucosa	mucosa	NN
cord-290677-3gdcyrrz	126	22	could	could	MD
cord-290677-3gdcyrrz	126	23	lead	lead	VB
cord-290677-3gdcyrrz	126	24	to	to	IN
cord-290677-3gdcyrrz	126	25	aberrant	aberrant	JJ
cord-290677-3gdcyrrz	126	26	pulmonary	pulmonary	JJ
cord-290677-3gdcyrrz	126	27	function	function	NN
cord-290677-3gdcyrrz	126	28	and	and	CC
cord-290677-3gdcyrrz	126	29	immunological	immunological	JJ
cord-290677-3gdcyrrz	126	30	modulation	modulation	NN
cord-290677-3gdcyrrz	126	31	.	.	.
cord-290677-3gdcyrrz	127	1	Age	age	NN
cord-290677-3gdcyrrz	127	2	-	-	HYPH
cord-290677-3gdcyrrz	127	3	related	relate	VBN
cord-290677-3gdcyrrz	127	4	disruption	disruption	NN
cord-290677-3gdcyrrz	127	5	of	of	IN
cord-290677-3gdcyrrz	127	6	the	the	DT
cord-290677-3gdcyrrz	127	7	crosstalk	crosstalk	NN
cord-290677-3gdcyrrz	127	8	between	between	IN
cord-290677-3gdcyrrz	127	9	the	the	DT
cord-290677-3gdcyrrz	127	10	nervous	nervous	JJ
cord-290677-3gdcyrrz	127	11	and	and	CC
cord-290677-3gdcyrrz	127	12	immune	immune	JJ
cord-290677-3gdcyrrz	127	13	systems	system	NNS
cord-290677-3gdcyrrz	127	14	might	may	MD
cord-290677-3gdcyrrz	127	15	lead	lead	VB
cord-290677-3gdcyrrz	127	16	to	to	IN
cord-290677-3gdcyrrz	127	17	impaired	impaired	JJ
cord-290677-3gdcyrrz	127	18	immunity	immunity	NN
cord-290677-3gdcyrrz	127	19	,	,	,
cord-290677-3gdcyrrz	127	20	clearance	clearance	NN
cord-290677-3gdcyrrz	127	21	and	and	CC
cord-290677-3gdcyrrz	127	22	contractility	contractility	NN
cord-290677-3gdcyrrz	127	23	of	of	IN
cord-290677-3gdcyrrz	127	24	the	the	DT
cord-290677-3gdcyrrz	127	25	airways	airway	NNS
cord-290677-3gdcyrrz	127	26	and	and	CC
cord-290677-3gdcyrrz	127	27	could	could	MD
cord-290677-3gdcyrrz	127	28	potentially	potentially	RB
cord-290677-3gdcyrrz	127	29	contribute	contribute	VB
cord-290677-3gdcyrrz	127	30	to	to	IN
cord-290677-3gdcyrrz	127	31	the	the	DT
cord-290677-3gdcyrrz	127	32	cytokine	cytokine	NN
cord-290677-3gdcyrrz	127	33	storm	storm	NN
cord-290677-3gdcyrrz	127	34	and	and	CC
cord-290677-3gdcyrrz	127	35	ARDS	ARDS	NNP
cord-290677-3gdcyrrz	127	36	in	in	IN
cord-290677-3gdcyrrz	127	37	people	people	NNS
cord-290677-3gdcyrrz	127	38	with	with	IN
cord-290677-3gdcyrrz	127	39	severe	severe	JJ
cord-290677-3gdcyrrz	127	40	COVID-19	covid-19	NN
cord-290677-3gdcyrrz	127	41	.	.	.
cord-290677-3gdcyrrz	128	1	The	the	DT
cord-290677-3gdcyrrz	128	2	high	high	JJ
cord-290677-3gdcyrrz	128	3	infectivity	infectivity	NN
cord-290677-3gdcyrrz	128	4	of	of	IN
cord-290677-3gdcyrrz	128	5	SARS	SARS	NNP
cord-290677-3gdcyrrz	128	6	-	-	HYPH
cord-290677-3gdcyrrz	128	7	CoV-2	CoV-2	NNP
cord-290677-3gdcyrrz	128	8	and	and	CC
cord-290677-3gdcyrrz	128	9	the	the	DT
cord-290677-3gdcyrrz	128	10	severe	severe	JJ
cord-290677-3gdcyrrz	128	11	morbidity	morbidity	NN
cord-290677-3gdcyrrz	128	12	associated	associate	VBN
cord-290677-3gdcyrrz	128	13	with	with	IN
cord-290677-3gdcyrrz	128	14	SARS	SARS	NNP
cord-290677-3gdcyrrz	128	15	-	-	HYPH
cord-290677-3gdcyrrz	128	16	CoV-2	CoV-2	NNP
cord-290677-3gdcyrrz	128	17	infection	infection	NN
cord-290677-3gdcyrrz	128	18	,	,	,
cord-290677-3gdcyrrz	128	19	along	along	IN
cord-290677-3gdcyrrz	128	20	with	with	IN
cord-290677-3gdcyrrz	128	21	our	-PRON-	PRP$
cord-290677-3gdcyrrz	128	22	limited	limited	JJ
cord-290677-3gdcyrrz	128	23	understanding	understanding	NN
cord-290677-3gdcyrrz	128	24	of	of	IN
cord-290677-3gdcyrrz	128	25	the	the	DT
cord-290677-3gdcyrrz	128	26	biology	biology	NN
cord-290677-3gdcyrrz	128	27	of	of	IN
cord-290677-3gdcyrrz	128	28	the	the	DT
cord-290677-3gdcyrrz	128	29	virus	virus	NN
cord-290677-3gdcyrrz	128	30	and	and	CC
cord-290677-3gdcyrrz	128	31	a	a	DT
cord-290677-3gdcyrrz	128	32	lack	lack	NN
cord-290677-3gdcyrrz	128	33	of	of	IN
cord-290677-3gdcyrrz	128	34	effective	effective	JJ
cord-290677-3gdcyrrz	128	35	treatments	treatment	NNS
cord-290677-3gdcyrrz	128	36	or	or	CC
cord-290677-3gdcyrrz	128	37	vaccines	vaccine	NNS
cord-290677-3gdcyrrz	128	38	for	for	IN
cord-290677-3gdcyrrz	128	39	COVID-19	COVID-19	NNP
cord-290677-3gdcyrrz	128	40	,	,	,
cord-290677-3gdcyrrz	128	41	has	have	VBZ
cord-290677-3gdcyrrz	128	42	made	make	VBN
cord-290677-3gdcyrrz	128	43	the	the	DT
cord-290677-3gdcyrrz	128	44	COVID-19	COVID-19	NNP
cord-290677-3gdcyrrz	128	45	outbreak	outbreak	NN
cord-290677-3gdcyrrz	128	46	a	a	DT
cord-290677-3gdcyrrz	128	47	global	global	JJ
cord-290677-3gdcyrrz	128	48	emergency	emergency	NN
cord-290677-3gdcyrrz	128	49	.	.	.
cord-290677-3gdcyrrz	129	1	The	the	DT
cord-290677-3gdcyrrz	129	2	principal	principal	JJ
cord-290677-3gdcyrrz	129	3	lethal	lethal	JJ
cord-290677-3gdcyrrz	129	4	threats	threat	NNS
cord-290677-3gdcyrrz	129	5	for	for	IN
cord-290677-3gdcyrrz	129	6	patients	patient	NNS
cord-290677-3gdcyrrz	129	7	with	with	IN
cord-290677-3gdcyrrz	129	8	COVID-19	COVID-19	NNP
cord-290677-3gdcyrrz	129	9	are	be	VBP
cord-290677-3gdcyrrz	129	10	ARDS	ARDS	NNP
cord-290677-3gdcyrrz	129	11	and	and	CC
cord-290677-3gdcyrrz	129	12	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	129	13	failure	failure	NN
cord-290677-3gdcyrrz	129	14	.	.	.
cord-290677-3gdcyrrz	130	1	These	these	DT
cord-290677-3gdcyrrz	130	2	complications	complication	NNS
cord-290677-3gdcyrrz	130	3	of	of	IN
cord-290677-3gdcyrrz	130	4	SARS	SARS	NNP
cord-290677-3gdcyrrz	130	5	-	-	HYPH
cord-290677-3gdcyrrz	130	6	CoV-2	CoV-2	NNP
cord-290677-3gdcyrrz	130	7	infection	infection	NN
cord-290677-3gdcyrrz	130	8	are	be	VBP
cord-290677-3gdcyrrz	130	9	predominantly	predominantly	RB
cord-290677-3gdcyrrz	130	10	observed	observe	VBN
cord-290677-3gdcyrrz	130	11	in	in	IN
cord-290677-3gdcyrrz	130	12	older	old	JJR
cord-290677-3gdcyrrz	130	13	86	86	CD
cord-290677-3gdcyrrz	130	14	and	and	CC
cord-290677-3gdcyrrz	130	15	immunocompromised	immunocompromised	JJ
cord-290677-3gdcyrrz	130	16	people	people	NNS
cord-290677-3gdcyrrz	130	17	86	86	CD
cord-290677-3gdcyrrz	130	18	and	and	CC
cord-290677-3gdcyrrz	130	19	are	be	VBP
cord-290677-3gdcyrrz	130	20	mainly	mainly	RB
cord-290677-3gdcyrrz	130	21	due	due	JJ
cord-290677-3gdcyrrz	130	22	to	to	IN
cord-290677-3gdcyrrz	130	23	hyperreactivity	hyperreactivity	NN
cord-290677-3gdcyrrz	130	24	and	and	CC
cord-290677-3gdcyrrz	130	25	maladaptive	maladaptive	JJ
cord-290677-3gdcyrrz	130	26	responses	response	NNS
cord-290677-3gdcyrrz	130	27	of	of	IN
cord-290677-3gdcyrrz	130	28	the	the	DT
cord-290677-3gdcyrrz	130	29	immune	immune	JJ
cord-290677-3gdcyrrz	130	30	system	system	NN
cord-290677-3gdcyrrz	130	31	,	,	,
cord-290677-3gdcyrrz	130	32	which	which	WDT
cord-290677-3gdcyrrz	130	33	is	be	VBZ
cord-290677-3gdcyrrz	130	34	unable	unable	JJ
cord-290677-3gdcyrrz	130	35	to	to	TO
cord-290677-3gdcyrrz	130	36	mount	mount	VB
cord-290677-3gdcyrrz	130	37	a	a	DT
cord-290677-3gdcyrrz	130	38	balanced	balanced	JJ
cord-290677-3gdcyrrz	130	39	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	130	40	response	response	NN
cord-290677-3gdcyrrz	130	41	and	and	CC
cord-290677-3gdcyrrz	130	42	instead	instead	RB
cord-290677-3gdcyrrz	130	43	produces	produce	VBZ
cord-290677-3gdcyrrz	130	44	a	a	DT
cord-290677-3gdcyrrz	130	45	sustained	sustained	JJ
cord-290677-3gdcyrrz	130	46	,	,	,
cord-290677-3gdcyrrz	130	47	ineffective	ineffective	JJ
cord-290677-3gdcyrrz	130	48	and	and	CC
cord-290677-3gdcyrrz	130	49	often	often	RB
cord-290677-3gdcyrrz	130	50	detrimental	detrimental	JJ
cord-290677-3gdcyrrz	130	51	reaction	reaction	NN
cord-290677-3gdcyrrz	130	52	known	know	VBN
cord-290677-3gdcyrrz	130	53	as	as	IN
cord-290677-3gdcyrrz	130	54	a	a	DT
cord-290677-3gdcyrrz	130	55	cytokine	cytokine	NN
cord-290677-3gdcyrrz	130	56	storm	storm	NN
cord-290677-3gdcyrrz	130	57	.	.	.
cord-290677-3gdcyrrz	131	1	Age	age	NN
cord-290677-3gdcyrrz	131	2	-	-	HYPH
cord-290677-3gdcyrrz	131	3	related	relate	VBN
cord-290677-3gdcyrrz	131	4	increases	increase	NNS
cord-290677-3gdcyrrz	131	5	in	in	IN
cord-290677-3gdcyrrz	131	6	pro	pro	JJ
cord-290677-3gdcyrrz	131	7	-	-	JJ
cord-290677-3gdcyrrz	131	8	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	131	9	cytokine	cytokine	NN
cord-290677-3gdcyrrz	131	10	levels	level	NNS
cord-290677-3gdcyrrz	131	11	and	and	CC
cord-290677-3gdcyrrz	131	12	decreases	decrease	NNS
cord-290677-3gdcyrrz	131	13	in	in	IN
cord-290677-3gdcyrrz	131	14	the	the	DT
cord-290677-3gdcyrrz	131	15	efficiency	efficiency	NN
cord-290677-3gdcyrrz	131	16	of	of	IN
cord-290677-3gdcyrrz	131	17	immune	immune	JJ
cord-290677-3gdcyrrz	131	18	effector	effector	NN
cord-290677-3gdcyrrz	131	19	cells	cell	NNS
cord-290677-3gdcyrrz	131	20	,	,	,
cord-290677-3gdcyrrz	131	21	such	such	JJ
cord-290677-3gdcyrrz	131	22	as	as	IN
cord-290677-3gdcyrrz	131	23	macrophages	macrophage	NNS
cord-290677-3gdcyrrz	131	24	or	or	CC
cord-290677-3gdcyrrz	131	25	T	t	NN
cord-290677-3gdcyrrz	131	26	cells	cell	NNS
cord-290677-3gdcyrrz	131	27	,	,	,
cord-290677-3gdcyrrz	131	28	could	could	MD
cord-290677-3gdcyrrz	131	29	make	make	VB
cord-290677-3gdcyrrz	131	30	older	old	JJR
cord-290677-3gdcyrrz	131	31	and	and	CC
cord-290677-3gdcyrrz	131	32	immunocompromised	immunocompromised	JJ
cord-290677-3gdcyrrz	131	33	people	people	NNS
cord-290677-3gdcyrrz	131	34	particularly	particularly	RB
cord-290677-3gdcyrrz	131	35	vulnerable	vulnerable	JJ
cord-290677-3gdcyrrz	131	36	to	to	IN
cord-290677-3gdcyrrz	131	37	the	the	DT
cord-290677-3gdcyrrz	131	38	virus	virus	NN
cord-290677-3gdcyrrz	131	39	.	.	.
cord-290677-3gdcyrrz	132	1	Treatments	treatment	NNS
cord-290677-3gdcyrrz	132	2	that	that	WDT
cord-290677-3gdcyrrz	132	3	target	target	VBP
cord-290677-3gdcyrrz	132	4	immune	immune	JJ
cord-290677-3gdcyrrz	132	5	cells	cell	NNS
cord-290677-3gdcyrrz	132	6	or	or	CC
cord-290677-3gdcyrrz	132	7	pro	pro	JJ
cord-290677-3gdcyrrz	132	8	-	-	JJ
cord-290677-3gdcyrrz	132	9	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	132	10	cytokines	cytokine	NNS
cord-290677-3gdcyrrz	132	11	have	have	VBP
cord-290677-3gdcyrrz	132	12	been	be	VBN
cord-290677-3gdcyrrz	132	13	tested	test	VBN
cord-290677-3gdcyrrz	132	14	with	with	IN
cord-290677-3gdcyrrz	132	15	some	some	DT
cord-290677-3gdcyrrz	132	16	degree	degree	NN
cord-290677-3gdcyrrz	132	17	of	of	IN
cord-290677-3gdcyrrz	132	18	success	success	NN
cord-290677-3gdcyrrz	132	19	,	,	,
cord-290677-3gdcyrrz	132	20	but	but	CC
cord-290677-3gdcyrrz	132	21	the	the	DT
cord-290677-3gdcyrrz	132	22	role	role	NN
cord-290677-3gdcyrrz	132	23	of	of	IN
cord-290677-3gdcyrrz	132	24	neuroimmune	neuroimmune	NNP
cord-290677-3gdcyrrz	132	25	crosstalk	crosstalk	NN
cord-290677-3gdcyrrz	132	26	in	in	IN
cord-290677-3gdcyrrz	132	27	the	the	DT
cord-290677-3gdcyrrz	132	28	context	context	NN
cord-290677-3gdcyrrz	132	29	of	of	IN
cord-290677-3gdcyrrz	132	30	infectious	infectious	JJ
cord-290677-3gdcyrrz	132	31	and	and	CC
cord-290677-3gdcyrrz	132	32	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	132	33	diseases	disease	NNS
cord-290677-3gdcyrrz	132	34	,	,	,
cord-290677-3gdcyrrz	132	35	including	include	VBG
cord-290677-3gdcyrrz	132	36	SARS	SARS	NNP
cord-290677-3gdcyrrz	132	37	-	-	HYPH
cord-290677-3gdcyrrz	132	38	CoV-2	CoV-2	NNP
cord-290677-3gdcyrrz	132	39	infection	infection	NN
cord-290677-3gdcyrrz	132	40	,	,	,
cord-290677-3gdcyrrz	132	41	has	have	VBZ
cord-290677-3gdcyrrz	132	42	been	be	VBN
cord-290677-3gdcyrrz	132	43	largely	largely	RB
cord-290677-3gdcyrrz	132	44	overlooked	overlook	VBN
cord-290677-3gdcyrrz	132	45	.	.	.
cord-290677-3gdcyrrz	133	1	Nevertheless	nevertheless	RB
cord-290677-3gdcyrrz	133	2	,	,	,
cord-290677-3gdcyrrz	133	3	strong	strong	JJ
cord-290677-3gdcyrrz	133	4	evidence	evidence	NN
cord-290677-3gdcyrrz	133	5	exists	exist	VBZ
cord-290677-3gdcyrrz	133	6	of	of	IN
cord-290677-3gdcyrrz	133	7	a	a	DT
cord-290677-3gdcyrrz	133	8	mutual	mutual	JJ
cord-290677-3gdcyrrz	133	9	association	association	NN
cord-290677-3gdcyrrz	133	10	between	between	IN
cord-290677-3gdcyrrz	133	11	nerve	nerve	NN
cord-290677-3gdcyrrz	133	12	and	and	CC
cord-290677-3gdcyrrz	133	13	immune	immune	JJ
cord-290677-3gdcyrrz	133	14	cells	cell	NNS
cord-290677-3gdcyrrz	133	15	,	,	,
cord-290677-3gdcyrrz	133	16	with	with	IN
cord-290677-3gdcyrrz	133	17	aberrant	aberrant	JJ
cord-290677-3gdcyrrz	133	18	activity	activity	NN
cord-290677-3gdcyrrz	133	19	of	of	IN
cord-290677-3gdcyrrz	133	20	one	one	CD
cord-290677-3gdcyrrz	133	21	cell	cell	NN
cord-290677-3gdcyrrz	133	22	type	type	NN
cord-290677-3gdcyrrz	133	23	affecting	affect	VBG
cord-290677-3gdcyrrz	133	24	the	the	DT
cord-290677-3gdcyrrz	133	25	other	other	JJ
cord-290677-3gdcyrrz	133	26	.	.	.
cord-290677-3gdcyrrz	134	1	In	in	IN
cord-290677-3gdcyrrz	134	2	the	the	DT
cord-290677-3gdcyrrz	134	3	context	context	NN
cord-290677-3gdcyrrz	134	4	of	of	IN
cord-290677-3gdcyrrz	134	5	SARS	SARS	NNP
cord-290677-3gdcyrrz	134	6	-	-	HYPH
cord-290677-3gdcyrrz	134	7	CoV-2	CoV-2	NNP
cord-290677-3gdcyrrz	134	8	infection	infection	NN
cord-290677-3gdcyrrz	134	9	,	,	,
cord-290677-3gdcyrrz	134	10	specific	specific	JJ
cord-290677-3gdcyrrz	134	11	tissueresident	tissueresident	JJ
cord-290677-3gdcyrrz	134	12	macrophages	macrophage	NNS
cord-290677-3gdcyrrz	134	13	that	that	WDT
cord-290677-3gdcyrrz	134	14	are	be	VBP
cord-290677-3gdcyrrz	134	15	involved	involve	VBN
cord-290677-3gdcyrrz	134	16	in	in	IN
cord-290677-3gdcyrrz	134	17	modulating	modulate	VBG
cord-290677-3gdcyrrz	134	18	inflammation	inflammation	NN
cord-290677-3gdcyrrz	134	19	following	follow	VBG
cord-290677-3gdcyrrz	134	20	viral	viral	JJ
cord-290677-3gdcyrrz	134	21	infection	infection	NN
cord-290677-3gdcyrrz	134	22	are	be	VBP
cord-290677-3gdcyrrz	134	23	in	in	IN
cord-290677-3gdcyrrz	134	24	close	close	JJ
cord-290677-3gdcyrrz	134	25	contact	contact	NN
cord-290677-3gdcyrrz	134	26	with	with	IN
cord-290677-3gdcyrrz	134	27	vagal	vagal	JJ
cord-290677-3gdcyrrz	134	28	fibres	fibre	NNS
cord-290677-3gdcyrrz	134	29	innervating	innervate	VBG
cord-290677-3gdcyrrz	134	30	the	the	DT
cord-290677-3gdcyrrz	134	31	lungs	lung	NNS
cord-290677-3gdcyrrz	134	32	,	,	,
cord-290677-3gdcyrrz	134	33	and	and	CC
cord-290677-3gdcyrrz	134	34	this	this	DT
cord-290677-3gdcyrrz	134	35	'	'	``
cord-290677-3gdcyrrz	134	36	neuroimmune	neuroimmune	NNP
cord-290677-3gdcyrrz	134	37	synapse	synapse	NNP
cord-290677-3gdcyrrz	134	38	'	'	''
cord-290677-3gdcyrrz	134	39	could	could	MD
cord-290677-3gdcyrrz	134	40	be	be	VB
cord-290677-3gdcyrrz	134	41	one	one	CD
cord-290677-3gdcyrrz	134	42	of	of	IN
cord-290677-3gdcyrrz	134	43	the	the	DT
cord-290677-3gdcyrrz	134	44	keys	key	NNS
cord-290677-3gdcyrrz	134	45	to	to	IN
cord-290677-3gdcyrrz	134	46	controlling	control	VBG
cord-290677-3gdcyrrz	134	47	aberrant	aberrant	JJ
cord-290677-3gdcyrrz	134	48	inflammation	inflammation	NN
cord-290677-3gdcyrrz	134	49	in	in	IN
cord-290677-3gdcyrrz	134	50	patients	patient	NNS
cord-290677-3gdcyrrz	134	51	with	with	IN
cord-290677-3gdcyrrz	134	52	severe	severe	JJ
cord-290677-3gdcyrrz	134	53	COVID-19	covid-19	NN
cord-290677-3gdcyrrz	134	54	.	.	.
cord-290677-3gdcyrrz	135	1	In	in	IN
cord-290677-3gdcyrrz	135	2	addition	addition	NN
cord-290677-3gdcyrrz	135	3	,	,	,
cord-290677-3gdcyrrz	135	4	in	in	IN
cord-290677-3gdcyrrz	135	5	several	several	JJ
cord-290677-3gdcyrrz	135	6	studies	study	NNS
cord-290677-3gdcyrrz	135	7	neurological	neurological	JJ
cord-290677-3gdcyrrz	135	8	symptoms	symptom	NNS
cord-290677-3gdcyrrz	135	9	have	have	VBP
cord-290677-3gdcyrrz	135	10	been	be	VBN
cord-290677-3gdcyrrz	135	11	observed	observe	VBN
cord-290677-3gdcyrrz	135	12	in	in	IN
cord-290677-3gdcyrrz	135	13	patients	patient	NNS
cord-290677-3gdcyrrz	135	14	with	with	IN
cord-290677-3gdcyrrz	135	15	COVID-19	COVID-19	NNP
cord-290677-3gdcyrrz	135	16	(	(	-LRB-
cord-290677-3gdcyrrz	135	17	refs	ref	NNS
cord-290677-3gdcyrrz	135	18	4,5,13,87	4,5,13,87	CD
cord-290677-3gdcyrrz	135	19	)	)	-RRB-
cord-290677-3gdcyrrz	135	20	,	,	,
cord-290677-3gdcyrrz	135	21	suggesting	suggest	VBG
cord-290677-3gdcyrrz	135	22	a	a	DT
cord-290677-3gdcyrrz	135	23	possible	possible	JJ
cord-290677-3gdcyrrz	135	24	role	role	NN
cord-290677-3gdcyrrz	135	25	for	for	IN
cord-290677-3gdcyrrz	135	26	the	the	DT
cord-290677-3gdcyrrz	135	27	nervous	nervous	JJ
cord-290677-3gdcyrrz	135	28	system	system	NN
cord-290677-3gdcyrrz	135	29	in	in	IN
cord-290677-3gdcyrrz	135	30	disease	disease	NN
cord-290677-3gdcyrrz	135	31	progression	progression	NN
cord-290677-3gdcyrrz	135	32	.	.	.
cord-290677-3gdcyrrz	136	1	A	a	DT
cord-290677-3gdcyrrz	136	2	feasible	feasible	JJ
cord-290677-3gdcyrrz	136	3	clinical	clinical	JJ
cord-290677-3gdcyrrz	136	4	approach	approach	NN
cord-290677-3gdcyrrz	136	5	to	to	IN
cord-290677-3gdcyrrz	136	6	COVID-19	COVID-19	NNP
cord-290677-3gdcyrrz	136	7	could	could	MD
cord-290677-3gdcyrrz	136	8	involve	involve	VB
cord-290677-3gdcyrrz	136	9	the	the	DT
cord-290677-3gdcyrrz	136	10	modulation	modulation	NN
cord-290677-3gdcyrrz	136	11	of	of	IN
cord-290677-3gdcyrrz	136	12	the	the	DT
cord-290677-3gdcyrrz	136	13	pulmonary	pulmonary	JJ
cord-290677-3gdcyrrz	136	14	NIU	NIU	NNP
cord-290677-3gdcyrrz	136	15	by	by	IN
cord-290677-3gdcyrrz	136	16	VNS	VNS	NNP
cord-290677-3gdcyrrz	136	17	,	,	,
cord-290677-3gdcyrrz	136	18	using	use	VBG
cord-290677-3gdcyrrz	136	19	stimulators	stimulator	NNS
cord-290677-3gdcyrrz	136	20	that	that	WDT
cord-290677-3gdcyrrz	136	21	are	be	VBP
cord-290677-3gdcyrrz	136	22	currently	currently	RB
cord-290677-3gdcyrrz	136	23	available	available	JJ
cord-290677-3gdcyrrz	136	24	to	to	TO
cord-290677-3gdcyrrz	136	25	treat	treat	VB
cord-290677-3gdcyrrz	136	26	certain	certain	JJ
cord-290677-3gdcyrrz	136	27	forms	form	NNS
cord-290677-3gdcyrrz	136	28	of	of	IN
cord-290677-3gdcyrrz	136	29	pharmacoresistant	pharmacoresistant	JJ
cord-290677-3gdcyrrz	136	30	epilepsy	epilepsy	NN
cord-290677-3gdcyrrz	136	31	.	.	.
cord-290677-3gdcyrrz	137	1	VNS	VNS	NNP
cord-290677-3gdcyrrz	137	2	has	have	VBZ
cord-290677-3gdcyrrz	137	3	been	be	VBN
cord-290677-3gdcyrrz	137	4	shown	show	VBN
cord-290677-3gdcyrrz	137	5	to	to	TO
cord-290677-3gdcyrrz	137	6	reduce	reduce	VB
cord-290677-3gdcyrrz	137	7	lipopolysaccharide	lipopolysaccharide	NN
cord-290677-3gdcyrrz	137	8	-	-	HYPH
cord-290677-3gdcyrrz	137	9	induced	induce	VBN
cord-290677-3gdcyrrz	137	10	expression	expression	NN
cord-290677-3gdcyrrz	137	11	of	of	IN
cord-290677-3gdcyrrz	137	12	pro	pro	JJ
cord-290677-3gdcyrrz	137	13	-	-	JJ
cord-290677-3gdcyrrz	137	14	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	137	15	cytokines	cytokine	NNS
cord-290677-3gdcyrrz	137	16	such	such	JJ
cord-290677-3gdcyrrz	137	17	as	as	IN
cord-290677-3gdcyrrz	137	18	IL-1β	IL-1β	NNP
cord-290677-3gdcyrrz	137	19	,	,	,
cord-290677-3gdcyrrz	137	20	IL-6	IL-6	NNP
cord-290677-3gdcyrrz	137	21	and	and	CC
cord-290677-3gdcyrrz	137	22	TNF	TNF	NNP
cord-290677-3gdcyrrz	137	23	in	in	IN
cord-290677-3gdcyrrz	137	24	the	the	DT
cord-290677-3gdcyrrz	137	25	brain	brain	NN
cord-290677-3gdcyrrz	137	26	and	and	CC
cord-290677-3gdcyrrz	137	27	spleen	spleen	NN
cord-290677-3gdcyrrz	137	28	68	68	CD
cord-290677-3gdcyrrz	137	29	.	.	.
cord-290677-3gdcyrrz	138	1	As	as	IN
cord-290677-3gdcyrrz	138	2	the	the	DT
cord-290677-3gdcyrrz	138	3	vagus	vagus	NN
cord-290677-3gdcyrrz	138	4	nerve	nerve	NN
cord-290677-3gdcyrrz	138	5	extensively	extensively	RB
cord-290677-3gdcyrrz	138	6	innervates	innervate	VBZ
cord-290677-3gdcyrrz	138	7	the	the	DT
cord-290677-3gdcyrrz	138	8	lungs	lung	NNS
cord-290677-3gdcyrrz	138	9	,	,	,
cord-290677-3gdcyrrz	138	10	VNS	VNS	NNP
cord-290677-3gdcyrrz	138	11	could	could	MD
cord-290677-3gdcyrrz	138	12	potentially	potentially	RB
cord-290677-3gdcyrrz	138	13	exert	exert	VB
cord-290677-3gdcyrrz	138	14	anti	anti	JJ
cord-290677-3gdcyrrz	138	15	-	-	JJ
cord-290677-3gdcyrrz	138	16	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	138	17	actions	action	NNS
cord-290677-3gdcyrrz	138	18	on	on	IN
cord-290677-3gdcyrrz	138	19	the	the	DT
cord-290677-3gdcyrrz	138	20	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	138	21	tract	tract	NN
cord-290677-3gdcyrrz	138	22	.	.	.
cord-290677-3gdcyrrz	139	1	Vagal	vagal	JJ
cord-290677-3gdcyrrz	139	2	activity	activity	NN
cord-290677-3gdcyrrz	139	3	has	have	VBZ
cord-290677-3gdcyrrz	139	4	a	a	DT
cord-290677-3gdcyrrz	139	5	crucial	crucial	JJ
cord-290677-3gdcyrrz	139	6	role	role	NN
cord-290677-3gdcyrrz	139	7	in	in	IN
cord-290677-3gdcyrrz	139	8	lung	lung	NN
cord-290677-3gdcyrrz	139	9	physiology	physiology	NN
cord-290677-3gdcyrrz	139	10	by	by	IN
cord-290677-3gdcyrrz	139	11	controlling	control	VBG
cord-290677-3gdcyrrz	139	12	airway	airway	NN
cord-290677-3gdcyrrz	139	13	smooth	smooth	JJ
cord-290677-3gdcyrrz	139	14	muscle	muscle	NN
cord-290677-3gdcyrrz	139	15	tone	tone	NN
cord-290677-3gdcyrrz	139	16	,	,	,
cord-290677-3gdcyrrz	139	17	vasodilation	vasodilation	NN
cord-290677-3gdcyrrz	139	18	,	,	,
cord-290677-3gdcyrrz	139	19	mucus	mucus	NN
cord-290677-3gdcyrrz	139	20	secretion	secretion	NN
cord-290677-3gdcyrrz	139	21	and	and	CC
cord-290677-3gdcyrrz	139	22	mucociliary	mucociliary	JJ
cord-290677-3gdcyrrz	139	23	clearance	clearance	NN
cord-290677-3gdcyrrz	139	24	,	,	,
cord-290677-3gdcyrrz	139	25	mainly	mainly	RB
cord-290677-3gdcyrrz	139	26	through	through	IN
cord-290677-3gdcyrrz	139	27	muscarinic	muscarinic	JJ
cord-290677-3gdcyrrz	139	28	receptor	receptor	NN
cord-290677-3gdcyrrz	139	29	activity	activity	NN
cord-290677-3gdcyrrz	139	30	88	88	CD
cord-290677-3gdcyrrz	139	31	.	.	.
cord-290677-3gdcyrrz	140	1	In	in	IN
cord-290677-3gdcyrrz	140	2	healthy	healthy	JJ
cord-290677-3gdcyrrz	140	3	individuals	individual	NNS
cord-290677-3gdcyrrz	140	4	,	,	,
cord-290677-3gdcyrrz	140	5	muscarinic	muscarinic	JJ
cord-290677-3gdcyrrz	140	6	acetylcholine	acetylcholine	NN
cord-290677-3gdcyrrz	140	7	receptor	receptor	NN
cord-290677-3gdcyrrz	140	8	(	(	-LRB-
cord-290677-3gdcyrrz	140	9	mAChR	mAChR	NNP
cord-290677-3gdcyrrz	140	10	)	)	-RRB-
cord-290677-3gdcyrrz	140	11	physiology	physiology	NN
cord-290677-3gdcyrrz	140	12	is	be	VBZ
cord-290677-3gdcyrrz	140	13	in	in	IN
cord-290677-3gdcyrrz	140	14	homeostasis	homeostasis	NN
cord-290677-3gdcyrrz	140	15	;	;	:
cord-290677-3gdcyrrz	140	16	however	however	RB
cord-290677-3gdcyrrz	140	17	,	,	,
cord-290677-3gdcyrrz	140	18	following	follow	VBG
cord-290677-3gdcyrrz	140	19	SARS	SARS	NNP
cord-290677-3gdcyrrz	140	20	-	-	HYPH
cord-290677-3gdcyrrz	140	21	CoV-2	CoV-2	NNP
cord-290677-3gdcyrrz	140	22	infection	infection	NN
cord-290677-3gdcyrrz	140	23	,	,	,
cord-290677-3gdcyrrz	140	24	physiological	physiological	JJ
cord-290677-3gdcyrrz	140	25	responses	response	NNS
cord-290677-3gdcyrrz	140	26	may	may	MD
cord-290677-3gdcyrrz	140	27	be	be	VB
cord-290677-3gdcyrrz	140	28	disrupted	disrupt	VBN
cord-290677-3gdcyrrz	140	29	,	,	,
cord-290677-3gdcyrrz	140	30	leading	lead	VBG
cord-290677-3gdcyrrz	140	31	to	to	IN
cord-290677-3gdcyrrz	140	32	a	a	DT
cord-290677-3gdcyrrz	140	33	maladaptive	maladaptive	JJ
cord-290677-3gdcyrrz	140	34	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	140	35	response	response	NN
cord-290677-3gdcyrrz	140	36	.	.	.
cord-290677-3gdcyrrz	141	1	This	this	DT
cord-290677-3gdcyrrz	141	2	disruption	disruption	NN
cord-290677-3gdcyrrz	141	3	could	could	MD
cord-290677-3gdcyrrz	141	4	be	be	VB
cord-290677-3gdcyrrz	141	5	especially	especially	RB
cord-290677-3gdcyrrz	141	6	marked	mark	VBN
cord-290677-3gdcyrrz	141	7	in	in	IN
cord-290677-3gdcyrrz	141	8	older	old	JJR
cord-290677-3gdcyrrz	141	9	and	and	CC
cord-290677-3gdcyrrz	141	10	immunocompromised	immunocompromised	JJ
cord-290677-3gdcyrrz	141	11	individuals	individual	NNS
cord-290677-3gdcyrrz	141	12	,	,	,
cord-290677-3gdcyrrz	141	13	in	in	IN
cord-290677-3gdcyrrz	141	14	whom	whom	WP
cord-290677-3gdcyrrz	141	15	the	the	DT
cord-290677-3gdcyrrz	141	16	vagal	vagal	JJ
cord-290677-3gdcyrrz	141	17	tone	tone	NN
cord-290677-3gdcyrrz	141	18	is	be	VBZ
cord-290677-3gdcyrrz	141	19	typically	typically	RB
cord-290677-3gdcyrrz	141	20	altered	alter	VBN
cord-290677-3gdcyrrz	141	21	and	and	CC
cord-290677-3gdcyrrz	141	22	the	the	DT
cord-290677-3gdcyrrz	141	23	ageing	age	VBG
cord-290677-3gdcyrrz	141	24	-	-	HYPH
cord-290677-3gdcyrrz	141	25	dependent	dependent	JJ
cord-290677-3gdcyrrz	141	26	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	141	27	response	response	NN
cord-290677-3gdcyrrz	141	28	to	to	IN
cord-290677-3gdcyrrz	141	29	viral	viral	JJ
cord-290677-3gdcyrrz	141	30	infection	infection	NN
cord-290677-3gdcyrrz	141	31	is	be	VBZ
cord-290677-3gdcyrrz	141	32	poorly	poorly	RB
cord-290677-3gdcyrrz	141	33	controlled	control	VBN
cord-290677-3gdcyrrz	141	34	.	.	.
cord-290677-3gdcyrrz	142	1	The	the	DT
cord-290677-3gdcyrrz	142	2	exploration	exploration	NN
cord-290677-3gdcyrrz	142	3	of	of	IN
cord-290677-3gdcyrrz	142	4	VNS	VNS	NNP
cord-290677-3gdcyrrz	142	5	as	as	IN
cord-290677-3gdcyrrz	142	6	a	a	DT
cord-290677-3gdcyrrz	142	7	possible	possible	JJ
cord-290677-3gdcyrrz	142	8	treatment	treatment	NN
cord-290677-3gdcyrrz	142	9	for	for	IN
cord-290677-3gdcyrrz	142	10	COVID-19	COVID-19	NNP
cord-290677-3gdcyrrz	142	11	is	be	VBZ
cord-290677-3gdcyrrz	142	12	currently	currently	RB
cord-290677-3gdcyrrz	142	13	limited	limit	VBN
cord-290677-3gdcyrrz	142	14	by	by	IN
cord-290677-3gdcyrrz	142	15	the	the	DT
cord-290677-3gdcyrrz	142	16	complexity	complexity	NN
cord-290677-3gdcyrrz	142	17	of	of	IN
cord-290677-3gdcyrrz	142	18	vagus	vagus	JJ
cord-290677-3gdcyrrz	142	19	nerve	nerve	NN
cord-290677-3gdcyrrz	142	20	anatomy	anatomy	NN
cord-290677-3gdcyrrz	142	21	and	and	CC
cord-290677-3gdcyrrz	142	22	a	a	DT
cord-290677-3gdcyrrz	142	23	lack	lack	NN
cord-290677-3gdcyrrz	142	24	of	of	IN
cord-290677-3gdcyrrz	142	25	knowledge	knowledge	NN
cord-290677-3gdcyrrz	142	26	of	of	IN
cord-290677-3gdcyrrz	142	27	the	the	DT
cord-290677-3gdcyrrz	142	28	optimum	optimum	JJ
cord-290677-3gdcyrrz	142	29	stimulation	stimulation	NN
cord-290677-3gdcyrrz	142	30	parameters	parameter	NNS
cord-290677-3gdcyrrz	142	31	.	.	.
cord-290677-3gdcyrrz	143	1	Development	development	NN
cord-290677-3gdcyrrz	143	2	of	of	IN
cord-290677-3gdcyrrz	143	3	a	a	DT
cord-290677-3gdcyrrz	143	4	tailored	tailor	VBN
cord-290677-3gdcyrrz	143	5	neuromodulatory	neuromodulatory	NNP
cord-290677-3gdcyrrz	143	6	approach	approach	NN
cord-290677-3gdcyrrz	143	7	would	would	MD
cord-290677-3gdcyrrz	143	8	require	require	VB
cord-290677-3gdcyrrz	143	9	a	a	DT
cord-290677-3gdcyrrz	143	10	detailed	detailed	JJ
cord-290677-3gdcyrrz	143	11	investigation	investigation	NN
cord-290677-3gdcyrrz	143	12	of	of	IN
cord-290677-3gdcyrrz	143	13	vagus	vagus	NNP
cord-290677-3gdcyrrz	143	14	nerve	nerve	NN
cord-290677-3gdcyrrz	143	15	anatomy	anatomy	NN
cord-290677-3gdcyrrz	143	16	and	and	CC
cord-290677-3gdcyrrz	143	17	activity	activity	NN
cord-290677-3gdcyrrz	143	18	during	during	IN
cord-290677-3gdcyrrz	143	19	lung	lung	NN
cord-290677-3gdcyrrz	143	20	inflammation	inflammation	NN
cord-290677-3gdcyrrz	143	21	(	(	-LRB-
cord-290677-3gdcyrrz	143	22	fig	fig	NN
cord-290677-3gdcyrrz	143	23	.	.	.
cord-290677-3gdcyrrz	143	24	3	3	CD
cord-290677-3gdcyrrz	143	25	)	)	-RRB-
cord-290677-3gdcyrrz	143	26	.	.	.
cord-290677-3gdcyrrz	144	1	It	-PRON-	PRP
cord-290677-3gdcyrrz	144	2	is	be	VBZ
cord-290677-3gdcyrrz	144	3	known	know	VBN
cord-290677-3gdcyrrz	144	4	that	that	IN
cord-290677-3gdcyrrz	144	5	the	the	DT
cord-290677-3gdcyrrz	144	6	release	release	NN
cord-290677-3gdcyrrz	144	7	of	of	IN
cord-290677-3gdcyrrz	144	8	acetylcholine	acetylcholine	NN
cord-290677-3gdcyrrz	144	9	by	by	IN
cord-290677-3gdcyrrz	144	10	vagal	vagal	JJ
cord-290677-3gdcyrrz	144	11	terminations	termination	NNS
cord-290677-3gdcyrrz	144	12	in	in	IN
cord-290677-3gdcyrrz	144	13	the	the	DT
cord-290677-3gdcyrrz	144	14	airways	airway	NNS
cord-290677-3gdcyrrz	144	15	could	could	MD
cord-290677-3gdcyrrz	144	16	be	be	VB
cord-290677-3gdcyrrz	144	17	important	important	JJ
cord-290677-3gdcyrrz	144	18	not	not	RB
cord-290677-3gdcyrrz	144	19	only	only	RB
cord-290677-3gdcyrrz	144	20	for	for	IN
cord-290677-3gdcyrrz	144	21	smooth	smooth	JJ
cord-290677-3gdcyrrz	144	22	muscle	muscle	NN
cord-290677-3gdcyrrz	144	23	contraction	contraction	NN
cord-290677-3gdcyrrz	144	24	89	89	CD
cord-290677-3gdcyrrz	144	25	,	,	,
cord-290677-3gdcyrrz	144	26	mucus	mucus	NN
cord-290677-3gdcyrrz	144	27	secretion	secretion	NN
cord-290677-3gdcyrrz	144	28	90	90	CD
cord-290677-3gdcyrrz	144	29	,	,	,
cord-290677-3gdcyrrz	144	30	91	91	CD
cord-290677-3gdcyrrz	144	31	and	and	CC
cord-290677-3gdcyrrz	144	32	vasodilation	vasodilation	NN
cord-290677-3gdcyrrz	144	33	in	in	IN
cord-290677-3gdcyrrz	144	34	pulmonary	pulmonary	JJ
cord-290677-3gdcyrrz	144	35	vessels	vessel	NNS
cord-290677-3gdcyrrz	144	36	92	92	CD
cord-290677-3gdcyrrz	145	1	but	but	CC
cord-290677-3gdcyrrz	145	2	also	also	RB
cord-290677-3gdcyrrz	145	3	to	to	TO
cord-290677-3gdcyrrz	145	4	modulate	modulate	VB
cord-290677-3gdcyrrz	145	5	lung	lung	NN
cord-290677-3gdcyrrz	145	6	macrophage	macrophage	NN
cord-290677-3gdcyrrz	145	7	activity	activity	NN
cord-290677-3gdcyrrz	145	8	and	and	CC
cord-290677-3gdcyrrz	145	9	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	145	10	responses	response	NNS
cord-290677-3gdcyrrz	145	11	.	.	.
cord-290677-3gdcyrrz	146	1	A	a	DT
cord-290677-3gdcyrrz	146	2	functional	functional	JJ
cord-290677-3gdcyrrz	146	3	role	role	NN
cord-290677-3gdcyrrz	146	4	for	for	IN
cord-290677-3gdcyrrz	146	5	mAChRs	machrs	NN
cord-290677-3gdcyrrz	146	6	in	in	IN
cord-290677-3gdcyrrz	146	7	immune	immune	JJ
cord-290677-3gdcyrrz	146	8	responses	response	NNS
cord-290677-3gdcyrrz	146	9	has	have	VBZ
cord-290677-3gdcyrrz	146	10	been	be	VBN
cord-290677-3gdcyrrz	146	11	demonstrated	demonstrate	VBN
cord-290677-3gdcyrrz	146	12	in	in	IN
cord-290677-3gdcyrrz	146	13	lung	lung	NN
cord-290677-3gdcyrrz	146	14	mast	mast	NN
cord-290677-3gdcyrrz	146	15	cells	cell	NNS
cord-290677-3gdcyrrz	146	16	and	and	CC
cord-290677-3gdcyrrz	146	17	alveolar	alveolar	JJ
cord-290677-3gdcyrrz	146	18	macrophages	macrophage	NNS
cord-290677-3gdcyrrz	146	19	.	.	.
cord-290677-3gdcyrrz	147	1	For	for	IN
cord-290677-3gdcyrrz	147	2	instance	instance	NN
cord-290677-3gdcyrrz	147	3	,	,	,
cord-290677-3gdcyrrz	147	4	histamine	histamine	NN
cord-290677-3gdcyrrz	147	5	release	release	NN
cord-290677-3gdcyrrz	147	6	from	from	IN
cord-290677-3gdcyrrz	147	7	mast	mast	NN
cord-290677-3gdcyrrz	147	8	cells	cell	NNS
cord-290677-3gdcyrrz	147	9	is	be	VBZ
cord-290677-3gdcyrrz	147	10	blocked	block	VBN
cord-290677-3gdcyrrz	147	11	by	by	IN
cord-290677-3gdcyrrz	147	12	acetylcholine	acetylcholine	NN
cord-290677-3gdcyrrz	147	13	and	and	CC
cord-290677-3gdcyrrz	147	14	other	other	JJ
cord-290677-3gdcyrrz	147	15	mAChR	mAChR	NNP
cord-290677-3gdcyrrz	147	16	agonists	agonist	NNS
cord-290677-3gdcyrrz	147	17	in	in	IN
cord-290677-3gdcyrrz	147	18	human	human	JJ
cord-290677-3gdcyrrz	147	19	bronchi	bronchi	NN
cord-290677-3gdcyrrz	147	20	93	93	CD
cord-290677-3gdcyrrz	147	21	,	,	,
cord-290677-3gdcyrrz	147	22	94	94	CD
cord-290677-3gdcyrrz	147	23	.	.	.
cord-290677-3gdcyrrz	148	1	In	in	IN
cord-290677-3gdcyrrz	148	2	support	support	NN
cord-290677-3gdcyrrz	148	3	of	of	IN
cord-290677-3gdcyrrz	148	4	a	a	DT
cord-290677-3gdcyrrz	148	5	macrophage	macrophage	NN
cord-290677-3gdcyrrz	148	6	-	-	HYPH
cord-290677-3gdcyrrz	148	7	dependent	dependent	JJ
cord-290677-3gdcyrrz	148	8	mechanism	mechanism	NN
cord-290677-3gdcyrrz	148	9	,	,	,
cord-290677-3gdcyrrz	148	10	M3	M3	NNP
cord-290677-3gdcyrrz	148	11	receptor	receptor	NN
cord-290677-3gdcyrrz	148	12	antagonists	antagonist	NNS
cord-290677-3gdcyrrz	148	13	prevent	prevent	VBP
cord-290677-3gdcyrrz	148	14	acetylcholine	acetylcholine	NN
cord-290677-3gdcyrrz	148	15	-	-	HYPH
cord-290677-3gdcyrrz	148	16	induced	induce	VBN
cord-290677-3gdcyrrz	148	17	release	release	NN
cord-290677-3gdcyrrz	148	18	of	of	IN
cord-290677-3gdcyrrz	148	19	chemotactic	chemotactic	JJ
cord-290677-3gdcyrrz	148	20	cytokines	cytokine	NNS
cord-290677-3gdcyrrz	148	21	from	from	IN
cord-290677-3gdcyrrz	148	22	macrophages	macrophage	NNS
cord-290677-3gdcyrrz	148	23	95	95	CD
cord-290677-3gdcyrrz	148	24	.	.	.
cord-290677-3gdcyrrz	149	1	In	in	IN
cord-290677-3gdcyrrz	149	2	addition	addition	NN
cord-290677-3gdcyrrz	149	3	to	to	IN
cord-290677-3gdcyrrz	149	4	muscarinic	muscarinic	JJ
cord-290677-3gdcyrrz	149	5	-	-	HYPH
cord-290677-3gdcyrrz	149	6	dependent	dependent	JJ
cord-290677-3gdcyrrz	149	7	inflammation	inflammation	NN
cord-290677-3gdcyrrz	149	8	,	,	,
cord-290677-3gdcyrrz	149	9	nAChRs	nachr	NNS
cord-290677-3gdcyrrz	149	10	have	have	VBP
cord-290677-3gdcyrrz	149	11	been	be	VBN
cord-290677-3gdcyrrz	149	12	suggested	suggest	VBN
cord-290677-3gdcyrrz	149	13	to	to	TO
cord-290677-3gdcyrrz	149	14	serve	serve	VB
cord-290677-3gdcyrrz	149	15	as	as	IN
cord-290677-3gdcyrrz	149	16	co	co	NNS
cord-290677-3gdcyrrz	149	17	-	-	NNS
cord-290677-3gdcyrrz	149	18	receptors	receptor	NNS
cord-290677-3gdcyrrz	149	19	for	for	IN
cord-290677-3gdcyrrz	149	20	SARS	SARS	NNP
cord-290677-3gdcyrrz	149	21	-	-	HYPH
cord-290677-3gdcyrrz	149	22	CoV-2	CoV-2	NNP
cord-290677-3gdcyrrz	149	23	(	(	-LRB-
cord-290677-3gdcyrrz	149	24	ref	ref	NN
cord-290677-3gdcyrrz	149	25	.	.	.
cord-290677-3gdcyrrz	150	1	96	96	CD
cord-290677-3gdcyrrz	150	2	)	)	-RRB-
cord-290677-3gdcyrrz	150	3	.	.	.
cord-290677-3gdcyrrz	151	1	The	the	DT
cord-290677-3gdcyrrz	151	2	nAChR	nAChR	NNP
cord-290677-3gdcyrrz	151	3	pathways	pathway	NNS
cord-290677-3gdcyrrz	151	4	that	that	WDT
cord-290677-3gdcyrrz	151	5	respond	respond	VBP
cord-290677-3gdcyrrz	151	6	to	to	IN
cord-290677-3gdcyrrz	151	7	VNS	VNS	NNP
cord-290677-3gdcyrrz	151	8	can	can	MD
cord-290677-3gdcyrrz	151	9	modulate	modulate	VB
cord-290677-3gdcyrrz	151	10	inflammation	inflammation	NN
cord-290677-3gdcyrrz	151	11	via	via	IN
cord-290677-3gdcyrrz	151	12	α7nAChR	α7nachr	CD
cord-290677-3gdcyrrz	151	13	69	69	CD
cord-290677-3gdcyrrz	151	14	,	,	,
cord-290677-3gdcyrrz	151	15	which	which	WDT
cord-290677-3gdcyrrz	151	16	is	be	VBZ
cord-290677-3gdcyrrz	151	17	expressed	express	VBN
cord-290677-3gdcyrrz	151	18	by	by	IN
cord-290677-3gdcyrrz	151	19	macrophages	macrophage	NNS
cord-290677-3gdcyrrz	151	20	.	.	.
cord-290677-3gdcyrrz	152	1	Agonists	agonist	NNS
cord-290677-3gdcyrrz	152	2	of	of	IN
cord-290677-3gdcyrrz	152	3	α7nAChR	α7nachr	CD
cord-290677-3gdcyrrz	152	4	,	,	,
cord-290677-3gdcyrrz	152	5	including	include	VBG
cord-290677-3gdcyrrz	152	6	nicotine	nicotine	NN
cord-290677-3gdcyrrz	152	7	,	,	,
cord-290677-3gdcyrrz	152	8	have	have	VBP
cord-290677-3gdcyrrz	152	9	been	be	VBN
cord-290677-3gdcyrrz	152	10	proven	prove	VBN
cord-290677-3gdcyrrz	152	11	to	to	TO
cord-290677-3gdcyrrz	152	12	reduce	reduce	VB
cord-290677-3gdcyrrz	152	13	macrophage	macrophage	NN
cord-290677-3gdcyrrz	152	14	-	-	HYPH
cord-290677-3gdcyrrz	152	15	dependent	dependent	JJ
cord-290677-3gdcyrrz	152	16	cytokine	cytokine	NN
cord-290677-3gdcyrrz	152	17	production	production	NN
cord-290677-3gdcyrrz	152	18	and	and	CC
cord-290677-3gdcyrrz	152	19	inflammation	inflammation	NN
cord-290677-3gdcyrrz	152	20	in	in	IN
cord-290677-3gdcyrrz	152	21	animal	animal	NN
cord-290677-3gdcyrrz	152	22	models	model	NNS
cord-290677-3gdcyrrz	152	23	of	of	IN
cord-290677-3gdcyrrz	152	24	pancreatitis	pancreatitis	NN
cord-290677-3gdcyrrz	152	25	97	97	CD
cord-290677-3gdcyrrz	152	26	and	and	CC
cord-290677-3gdcyrrz	152	27	peritonitis	peritonitis	NN
cord-290677-3gdcyrrz	152	28	98	98	CD
cord-290677-3gdcyrrz	152	29	.	.	.
cord-290677-3gdcyrrz	153	1	Thus	thus	RB
cord-290677-3gdcyrrz	153	2	,	,	,
cord-290677-3gdcyrrz	153	3	nAChR	nAChR	NNP
cord-290677-3gdcyrrz	153	4	modulation	modulation	NN
cord-290677-3gdcyrrz	153	5	by	by	IN
cord-290677-3gdcyrrz	153	6	SARS	SARS	NNP
cord-290677-3gdcyrrz	153	7	-	-	HYPH
cord-290677-3gdcyrrz	153	8	CoV-2	CoV-2	NNP
cord-290677-3gdcyrrz	153	9	might	may	MD
cord-290677-3gdcyrrz	153	10	account	account	VB
cord-290677-3gdcyrrz	153	11	for	for	IN
cord-290677-3gdcyrrz	153	12	the	the	DT
cord-290677-3gdcyrrz	153	13	hyperinflammatory	hyperinflammatory	NNP
cord-290677-3gdcyrrz	153	14	features	feature	NNS
cord-290677-3gdcyrrz	153	15	that	that	WDT
cord-290677-3gdcyrrz	153	16	are	be	VBP
cord-290677-3gdcyrrz	153	17	observed	observe	VBN
cord-290677-3gdcyrrz	153	18	in	in	IN
cord-290677-3gdcyrrz	153	19	a	a	DT
cord-290677-3gdcyrrz	153	20	subgroup	subgroup	NN
cord-290677-3gdcyrrz	153	21	of	of	IN
cord-290677-3gdcyrrz	153	22	patients	patient	NNS
cord-290677-3gdcyrrz	153	23	with	with	IN
cord-290677-3gdcyrrz	153	24	COVID-19	COVID-19	NNP
cord-290677-3gdcyrrz	153	25	.	.	.
cord-290677-3gdcyrrz	154	1	Together	together	RB
cord-290677-3gdcyrrz	154	2	,	,	,
cord-290677-3gdcyrrz	154	3	these	these	DT
cord-290677-3gdcyrrz	154	4	observations	observation	NNS
cord-290677-3gdcyrrz	154	5	suggest	suggest	VBP
cord-290677-3gdcyrrz	154	6	that	that	IN
cord-290677-3gdcyrrz	154	7	the	the	DT
cord-290677-3gdcyrrz	154	8	use	use	NN
cord-290677-3gdcyrrz	154	9	of	of	IN
cord-290677-3gdcyrrz	154	10	clinically	clinically	RB
cord-290677-3gdcyrrz	154	11	suitable	suitable	JJ
cord-290677-3gdcyrrz	154	12	acetylcholine	acetylcholine	NN
cord-290677-3gdcyrrz	154	13	receptor	receptor	NN
cord-290677-3gdcyrrz	154	14	agonists	agonist	NNS
cord-290677-3gdcyrrz	154	15	or	or	CC
cord-290677-3gdcyrrz	154	16	antagonists	antagonist	NNS
cord-290677-3gdcyrrz	154	17	could	could	MD
cord-290677-3gdcyrrz	154	18	help	help	VB
cord-290677-3gdcyrrz	154	19	dampen	dampen	VB
cord-290677-3gdcyrrz	154	20	the	the	DT
cord-290677-3gdcyrrz	154	21	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	154	22	response	response	NN
cord-290677-3gdcyrrz	154	23	in	in	IN
cord-290677-3gdcyrrz	154	24	the	the	DT
cord-290677-3gdcyrrz	154	25	lung	lung	NN
cord-290677-3gdcyrrz	154	26	microenvironment	microenvironment	NN
cord-290677-3gdcyrrz	154	27	in	in	IN
cord-290677-3gdcyrrz	154	28	the	the	DT
cord-290677-3gdcyrrz	154	29	context	context	NN
cord-290677-3gdcyrrz	154	30	of	of	IN
cord-290677-3gdcyrrz	154	31	SARS	SARS	NNP
cord-290677-3gdcyrrz	154	32	-	-	HYPH
cord-290677-3gdcyrrz	154	33	CoV-2	CoV-2	NNP
cord-290677-3gdcyrrz	154	34	infection	infection	NN
cord-290677-3gdcyrrz	154	35	.	.	.
cord-290677-3gdcyrrz	155	1	Further	further	JJ
cord-290677-3gdcyrrz	155	2	studies	study	NNS
cord-290677-3gdcyrrz	155	3	are	be	VBP
cord-290677-3gdcyrrz	155	4	needed	need	VBN
cord-290677-3gdcyrrz	155	5	to	to	TO
cord-290677-3gdcyrrz	155	6	clarify	clarify	VB
cord-290677-3gdcyrrz	155	7	the	the	DT
cord-290677-3gdcyrrz	155	8	role	role	NN
cord-290677-3gdcyrrz	155	9	and	and	CC
cord-290677-3gdcyrrz	155	10	importance	importance	NN
cord-290677-3gdcyrrz	155	11	of	of	IN
cord-290677-3gdcyrrz	155	12	neuroimmune	neuroimmune	NNP
cord-290677-3gdcyrrz	155	13	crosstalk	crosstalk	NN
cord-290677-3gdcyrrz	155	14	both	both	DT
cord-290677-3gdcyrrz	155	15	in	in	IN
cord-290677-3gdcyrrz	155	16	patients	patient	NNS
cord-290677-3gdcyrrz	155	17	with	with	IN
cord-290677-3gdcyrrz	155	18	COVID-19	COVID-19	NNP
cord-290677-3gdcyrrz	155	19	and	and	CC
cord-290677-3gdcyrrz	155	20	in	in	IN
cord-290677-3gdcyrrz	155	21	animal	animal	NN
cord-290677-3gdcyrrz	155	22	models	model	NNS
cord-290677-3gdcyrrz	155	23	of	of	IN
cord-290677-3gdcyrrz	155	24	COVID-19	COVID-19	NNP
cord-290677-3gdcyrrz	155	25	(	(	-LRB-
cord-290677-3gdcyrrz	155	26	fig	fig	NN
cord-290677-3gdcyrrz	155	27	.	.	.
cord-290677-3gdcyrrz	155	28	3	3	CD
cord-290677-3gdcyrrz	155	29	)	)	-RRB-
cord-290677-3gdcyrrz	155	30	.	.	.
cord-290677-3gdcyrrz	156	1	The	the	DT
cord-290677-3gdcyrrz	156	2	use	use	NN
cord-290677-3gdcyrrz	156	3	of	of	IN
cord-290677-3gdcyrrz	156	4	animal	animal	NN
cord-290677-3gdcyrrz	156	5	models	model	NNS
cord-290677-3gdcyrrz	156	6	could	could	MD
cord-290677-3gdcyrrz	156	7	help	help	VB
cord-290677-3gdcyrrz	156	8	uncover	uncover	VB
cord-290677-3gdcyrrz	156	9	the	the	DT
cord-290677-3gdcyrrz	156	10	cellular	cellular	JJ
cord-290677-3gdcyrrz	156	11	and	and	CC
cord-290677-3gdcyrrz	156	12	molecular	molecular	JJ
cord-290677-3gdcyrrz	156	13	mechanisms	mechanism	NNS
cord-290677-3gdcyrrz	156	14	that	that	WDT
cord-290677-3gdcyrrz	156	15	underlie	underlie	VBP
cord-290677-3gdcyrrz	156	16	the	the	DT
cord-290677-3gdcyrrz	156	17	mutual	mutual	JJ
cord-290677-3gdcyrrz	156	18	relationships	relationship	NNS
cord-290677-3gdcyrrz	156	19	between	between	IN
cord-290677-3gdcyrrz	156	20	specific	specific	JJ
cord-290677-3gdcyrrz	156	21	nerve	nerve	NN
cord-290677-3gdcyrrz	156	22	fibres	fibre	NNS
cord-290677-3gdcyrrz	156	23	and	and	CC
cord-290677-3gdcyrrz	156	24	selected	select	VBN
cord-290677-3gdcyrrz	156	25	immune	immune	JJ
cord-290677-3gdcyrrz	156	26	cell	cell	NN
cord-290677-3gdcyrrz	156	27	subsets	subset	NNS
cord-290677-3gdcyrrz	156	28	.	.	.
cord-290677-3gdcyrrz	157	1	In	in	IN
cord-290677-3gdcyrrz	157	2	experimental	experimental	JJ
cord-290677-3gdcyrrz	157	3	models	model	NNS
cord-290677-3gdcyrrz	157	4	,	,	,
cord-290677-3gdcyrrz	157	5	chemogenetic	chemogenetic	JJ
cord-290677-3gdcyrrz	157	6	and	and	CC
cord-290677-3gdcyrrz	157	7	optogenetic	optogenetic	JJ
cord-290677-3gdcyrrz	157	8	techniques	technique	NNS
cord-290677-3gdcyrrz	157	9	can	can	MD
cord-290677-3gdcyrrz	157	10	be	be	VB
cord-290677-3gdcyrrz	157	11	used	use	VBN
cord-290677-3gdcyrrz	157	12	to	to	TO
cord-290677-3gdcyrrz	157	13	manipulate	manipulate	VB
cord-290677-3gdcyrrz	157	14	neuronal	neuronal	JJ
cord-290677-3gdcyrrz	157	15	activity	activity	NN
cord-290677-3gdcyrrz	157	16	by	by	IN
cord-290677-3gdcyrrz	157	17	targeting	target	VBG
cord-290677-3gdcyrrz	157	18	specific	specific	JJ
cord-290677-3gdcyrrz	157	19	nerve	nerve	NN
cord-290677-3gdcyrrz	157	20	fibres	fibre	NNS
cord-290677-3gdcyrrz	157	21	to	to	TO
cord-290677-3gdcyrrz	157	22	test	test	VB
cord-290677-3gdcyrrz	157	23	how	how	WRB
cord-290677-3gdcyrrz	157	24	they	-PRON-	PRP
cord-290677-3gdcyrrz	157	25	modulate	modulate	VBP
cord-290677-3gdcyrrz	157	26	immunity	immunity	NN
cord-290677-3gdcyrrz	157	27	.	.	.
cord-290677-3gdcyrrz	158	1	Selective	selective	JJ
cord-290677-3gdcyrrz	158	2	immune	immune	JJ
cord-290677-3gdcyrrz	158	3	cell	cell	NN
cord-290677-3gdcyrrz	158	4	depletion	depletion	NN
cord-290677-3gdcyrrz	158	5	or	or	CC
cord-290677-3gdcyrrz	158	6	immunomodulation	immunomodulation	NN
cord-290677-3gdcyrrz	158	7	could	could	MD
cord-290677-3gdcyrrz	158	8	provide	provide	VB
cord-290677-3gdcyrrz	158	9	further	further	JJ
cord-290677-3gdcyrrz	158	10	insights	insight	NNS
cord-290677-3gdcyrrz	158	11	into	into	IN
cord-290677-3gdcyrrz	158	12	neuroimmune	neuroimmune	NNP
cord-290677-3gdcyrrz	158	13	communication	communication	NN
cord-290677-3gdcyrrz	158	14	.	.	.
cord-290677-3gdcyrrz	159	1	In	in	IN
cord-290677-3gdcyrrz	159	2	the	the	DT
cord-290677-3gdcyrrz	159	3	clinic	clinic	NN
cord-290677-3gdcyrrz	159	4	,	,	,
cord-290677-3gdcyrrz	159	5	the	the	DT
cord-290677-3gdcyrrz	159	6	neuroimmune	neuroimmune	NNP
cord-290677-3gdcyrrz	159	7	synapses	synapsis	NNS
cord-290677-3gdcyrrz	159	8	could	could	MD
cord-290677-3gdcyrrz	159	9	be	be	VB
cord-290677-3gdcyrrz	159	10	visualized	visualize	VBN
cord-290677-3gdcyrrz	159	11	by	by	IN
cord-290677-3gdcyrrz	159	12	electron	electron	NN
cord-290677-3gdcyrrz	159	13	microscopy	microscopy	NNS
cord-290677-3gdcyrrz	159	14	and	and	CC
cord-290677-3gdcyrrz	159	15	further	further	RB
cord-290677-3gdcyrrz	159	16	analysed	analyse	VBN
cord-290677-3gdcyrrz	159	17	by	by	IN
cord-290677-3gdcyrrz	159	18	immunohistochemistry	immunohistochemistry	NN
cord-290677-3gdcyrrz	159	19	in	in	IN
cord-290677-3gdcyrrz	159	20	human	human	JJ
cord-290677-3gdcyrrz	159	21	biopsy	biopsy	NN
cord-290677-3gdcyrrz	159	22	or	or	CC
cord-290677-3gdcyrrz	159	23	post	post	JJ
cord-290677-3gdcyrrz	159	24	-	-	JJ
cord-290677-3gdcyrrz	159	25	mortem	mortem	JJ
cord-290677-3gdcyrrz	159	26	tissues	tissue	NNS
cord-290677-3gdcyrrz	159	27	.	.	.
cord-290677-3gdcyrrz	160	1	Human	human	JJ
cord-290677-3gdcyrrz	160	2	sputum	sputum	NN
cord-290677-3gdcyrrz	160	3	or	or	CC
cord-290677-3gdcyrrz	160	4	blood	blood	NN
cord-290677-3gdcyrrz	160	5	samples	sample	NNS
cord-290677-3gdcyrrz	160	6	,	,	,
cord-290677-3gdcyrrz	160	7	as	as	RB
cord-290677-3gdcyrrz	160	8	well	well	RB
cord-290677-3gdcyrrz	160	9	as	as	IN
cord-290677-3gdcyrrz	160	10	lung	lung	NN
cord-290677-3gdcyrrz	160	11	parenchyma	parenchyma	NNS
cord-290677-3gdcyrrz	160	12	obtained	obtain	VBN
cord-290677-3gdcyrrz	160	13	by	by	IN
cord-290677-3gdcyrrz	160	14	biopsy	biopsy	NN
cord-290677-3gdcyrrz	160	15	,	,	,
cord-290677-3gdcyrrz	160	16	could	could	MD
cord-290677-3gdcyrrz	160	17	also	also	RB
cord-290677-3gdcyrrz	160	18	be	be	VB
cord-290677-3gdcyrrz	160	19	tested	test	VBN
cord-290677-3gdcyrrz	160	20	for	for	IN
cord-290677-3gdcyrrz	160	21	the	the	DT
cord-290677-3gdcyrrz	160	22	presence	presence	NN
cord-290677-3gdcyrrz	160	23	of	of	IN
cord-290677-3gdcyrrz	160	24	specific	specific	JJ
cord-290677-3gdcyrrz	160	25	cytokines	cytokine	NNS
cord-290677-3gdcyrrz	160	26	and	and	CC
cord-290677-3gdcyrrz	160	27	cell	cell	NN
cord-290677-3gdcyrrz	160	28	types	type	NNS
cord-290677-3gdcyrrz	160	29	.	.	.
cord-290677-3gdcyrrz	161	1	The	the	DT
cord-290677-3gdcyrrz	161	2	presence	presence	NN
cord-290677-3gdcyrrz	161	3	of	of	IN
cord-290677-3gdcyrrz	161	4	ACE2	ACE2	NNP
cord-290677-3gdcyrrz	161	5	on	on	IN
cord-290677-3gdcyrrz	161	6	neurons	neuron	NNS
cord-290677-3gdcyrrz	161	7	makes	make	VBZ
cord-290677-3gdcyrrz	161	8	them	-PRON-	PRP
cord-290677-3gdcyrrz	161	9	susceptible	susceptible	JJ
cord-290677-3gdcyrrz	161	10	to	to	IN
cord-290677-3gdcyrrz	161	11	SARS	SARS	NNP
cord-290677-3gdcyrrz	161	12	-	-	HYPH
cord-290677-3gdcyrrz	161	13	CoV-2	CoV-2	NNP
cord-290677-3gdcyrrz	161	14	infection	infection	NN
cord-290677-3gdcyrrz	161	15	,	,	,
cord-290677-3gdcyrrz	161	16	which	which	WDT
cord-290677-3gdcyrrz	161	17	could	could	MD
cord-290677-3gdcyrrz	161	18	lead	lead	VB
cord-290677-3gdcyrrz	161	19	to	to	IN
cord-290677-3gdcyrrz	161	20	neuronal	neuronal	JJ
cord-290677-3gdcyrrz	161	21	damage	damage	NN
cord-290677-3gdcyrrz	161	22	and	and	CC
cord-290677-3gdcyrrz	161	23	aberrant	aberrant	JJ
cord-290677-3gdcyrrz	161	24	signalling	signalling	NN
cord-290677-3gdcyrrz	161	25	.	.	.
cord-290677-3gdcyrrz	162	1	Afferent	Afferent	NNP
cord-290677-3gdcyrrz	162	2	and	and	CC
cord-290677-3gdcyrrz	162	3	efferent	efferent	JJ
cord-290677-3gdcyrrz	162	4	vagal	vagal	JJ
cord-290677-3gdcyrrz	162	5	fibres	fibre	NNS
cord-290677-3gdcyrrz	162	6	are	be	VBP
cord-290677-3gdcyrrz	162	7	functionally	functionally	RB
cord-290677-3gdcyrrz	162	8	and	and	CC
cord-290677-3gdcyrrz	162	9	molecularly	molecularly	RB
cord-290677-3gdcyrrz	162	10	distinct	distinct	JJ
cord-290677-3gdcyrrz	162	11	as	as	IN
cord-290677-3gdcyrrz	162	12	they	-PRON-	PRP
cord-290677-3gdcyrrz	162	13	convey	convey	VBP
cord-290677-3gdcyrrz	162	14	information	information	NN
cord-290677-3gdcyrrz	162	15	in	in	IN
cord-290677-3gdcyrrz	162	16	opposite	opposite	JJ
cord-290677-3gdcyrrz	162	17	directions	direction	NNS
cord-290677-3gdcyrrz	162	18	,	,	,
cord-290677-3gdcyrrz	162	19	release	release	VB
cord-290677-3gdcyrrz	162	20	specific	specific	JJ
cord-290677-3gdcyrrz	162	21	neurotransmitters	neurotransmitter	NNS
cord-290677-3gdcyrrz	162	22	and	and	CC
cord-290677-3gdcyrrz	162	23	express	express	VB
cord-290677-3gdcyrrz	162	24	unique	unique	JJ
cord-290677-3gdcyrrz	162	25	combinations	combination	NNS
cord-290677-3gdcyrrz	162	26	of	of	IN
cord-290677-3gdcyrrz	162	27	receptors	receptor	NNS
cord-290677-3gdcyrrz	162	28	that	that	WDT
cord-290677-3gdcyrrz	162	29	could	could	MD
cord-290677-3gdcyrrz	162	30	communicate	communicate	VB
cord-290677-3gdcyrrz	162	31	with	with	IN
cord-290677-3gdcyrrz	162	32	different	different	JJ
cord-290677-3gdcyrrz	162	33	immune	immune	JJ
cord-290677-3gdcyrrz	162	34	cell	cell	NN
cord-290677-3gdcyrrz	162	35	subtypes	subtype	NNS
cord-290677-3gdcyrrz	162	36	.	.	.
cord-290677-3gdcyrrz	163	1	These	these	DT
cord-290677-3gdcyrrz	163	2	fibres	fibre	NNS
cord-290677-3gdcyrrz	163	3	comprise	comprise	VBP
cord-290677-3gdcyrrz	163	4	a	a	DT
cord-290677-3gdcyrrz	163	5	sensory	sensory	JJ
cord-290677-3gdcyrrz	163	6	-	-	HYPH
cord-290677-3gdcyrrz	163	7	motor	motor	NN
cord-290677-3gdcyrrz	163	8	feedback	feedback	NN
cord-290677-3gdcyrrz	163	9	loop	loop	NN
cord-290677-3gdcyrrz	163	10	that	that	WDT
cord-290677-3gdcyrrz	163	11	regulates	regulate	VBZ
cord-290677-3gdcyrrz	163	12	physiological	physiological	JJ
cord-290677-3gdcyrrz	163	13	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	163	14	functions	function	NNS
cord-290677-3gdcyrrz	163	15	,	,	,
cord-290677-3gdcyrrz	163	16	the	the	DT
cord-290677-3gdcyrrz	163	17	disruption	disruption	NN
cord-290677-3gdcyrrz	163	18	of	of	IN
cord-290677-3gdcyrrz	163	19	which	which	WDT
cord-290677-3gdcyrrz	163	20	by	by	IN
cord-290677-3gdcyrrz	163	21	viral	viral	JJ
cord-290677-3gdcyrrz	163	22	infection	infection	NN
cord-290677-3gdcyrrz	163	23	could	could	MD
cord-290677-3gdcyrrz	163	24	cause	cause	VB
cord-290677-3gdcyrrz	163	25	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	163	26	dysfunction	dysfunction	NN
cord-290677-3gdcyrrz	163	27	.	.	.
cord-290677-3gdcyrrz	164	1	The	the	DT
cord-290677-3gdcyrrz	164	2	vagus	vagus	NN
cord-290677-3gdcyrrz	164	3	nerve	nerve	NN
cord-290677-3gdcyrrz	164	4	could	could	MD
cord-290677-3gdcyrrz	164	5	also	also	RB
cord-290677-3gdcyrrz	164	6	provide	provide	VB
cord-290677-3gdcyrrz	164	7	an	an	DT
cord-290677-3gdcyrrz	164	8	entry	entry	NN
cord-290677-3gdcyrrz	164	9	point	point	NN
cord-290677-3gdcyrrz	164	10	for	for	IN
cord-290677-3gdcyrrz	164	11	the	the	DT
cord-290677-3gdcyrrz	164	12	virus	virus	NN
cord-290677-3gdcyrrz	164	13	to	to	IN
cord-290677-3gdcyrrz	164	14	the	the	DT
cord-290677-3gdcyrrz	164	15	CNS	CNS	NNP
cord-290677-3gdcyrrz	164	16	,	,	,
cord-290677-3gdcyrrz	164	17	including	include	VBG
cord-290677-3gdcyrrz	164	18	areas	area	NNS
cord-290677-3gdcyrrz	164	19	of	of	IN
cord-290677-3gdcyrrz	164	20	the	the	DT
cord-290677-3gdcyrrz	164	21	brain	brain	NN
cord-290677-3gdcyrrz	164	22	that	that	WDT
cord-290677-3gdcyrrz	164	23	control	control	NN
cord-290677-3gdcyrrz	164	24	respiration	respiration	NN
cord-290677-3gdcyrrz	164	25	,	,	,
cord-290677-3gdcyrrz	164	26	such	such	JJ
cord-290677-3gdcyrrz	164	27	us	-PRON-	PRP
cord-290677-3gdcyrrz	164	28	the	the	DT
cord-290677-3gdcyrrz	164	29	NTS	NTS	NNPS
cord-290677-3gdcyrrz	164	30	.	.	.
cord-290677-3gdcyrrz	165	1	The	the	DT
cord-290677-3gdcyrrz	165	2	NTS	NTS	NNPS
cord-290677-3gdcyrrz	165	3	is	be	VBZ
cord-290677-3gdcyrrz	165	4	involved	involve	VBN
cord-290677-3gdcyrrz	165	5	in	in	IN
cord-290677-3gdcyrrz	165	6	the	the	DT
cord-290677-3gdcyrrz	165	7	control	control	NN
cord-290677-3gdcyrrz	165	8	of	of	IN
cord-290677-3gdcyrrz	165	9	several	several	JJ
cord-290677-3gdcyrrz	165	10	critical	critical	JJ
cord-290677-3gdcyrrz	165	11	functions	function	NNS
cord-290677-3gdcyrrz	165	12	besides	besides	IN
cord-290677-3gdcyrrz	165	13	respiration	respiration	NN
cord-290677-3gdcyrrz	165	14	that	that	WDT
cord-290677-3gdcyrrz	165	15	might	may	MD
cord-290677-3gdcyrrz	165	16	be	be	VB
cord-290677-3gdcyrrz	165	17	affected	affect	VBN
cord-290677-3gdcyrrz	165	18	following	follow	VBG
cord-290677-3gdcyrrz	165	19	infection	infection	NN
cord-290677-3gdcyrrz	165	20	,	,	,
cord-290677-3gdcyrrz	165	21	including	include	VBG
cord-290677-3gdcyrrz	165	22	cardiac	cardiac	JJ
cord-290677-3gdcyrrz	165	23	rhythm	rhythm	NN
cord-290677-3gdcyrrz	165	24	and	and	CC
cord-290677-3gdcyrrz	165	25	food	food	NN
cord-290677-3gdcyrrz	165	26	intake	intake	NN
cord-290677-3gdcyrrz	165	27	regulation	regulation	NN
cord-290677-3gdcyrrz	165	28	.	.	.
cord-290677-3gdcyrrz	166	1	Therefore	therefore	RB
cord-290677-3gdcyrrz	166	2	,	,	,
cord-290677-3gdcyrrz	166	3	vagal	vagal	JJ
cord-290677-3gdcyrrz	166	4	infection	infection	NN
cord-290677-3gdcyrrz	166	5	may	may	MD
cord-290677-3gdcyrrz	166	6	result	result	VB
cord-290677-3gdcyrrz	166	7	not	not	RB
cord-290677-3gdcyrrz	166	8	only	only	RB
cord-290677-3gdcyrrz	166	9	in	in	IN
cord-290677-3gdcyrrz	166	10	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	166	11	distress	distress	NN
cord-290677-3gdcyrrz	166	12	but	but	CC
cord-290677-3gdcyrrz	166	13	also	also	RB
cord-290677-3gdcyrrz	166	14	in	in	IN
cord-290677-3gdcyrrz	166	15	other	other	JJ
cord-290677-3gdcyrrz	166	16	symptoms	symptom	NNS
cord-290677-3gdcyrrz	166	17	such	such	JJ
cord-290677-3gdcyrrz	166	18	as	as	IN
cord-290677-3gdcyrrz	166	19	cardiac	cardiac	JJ
cord-290677-3gdcyrrz	166	20	dysfunction	dysfunction	NN
cord-290677-3gdcyrrz	166	21	or	or	CC
cord-290677-3gdcyrrz	166	22	loss	loss	NN
cord-290677-3gdcyrrz	166	23	of	of	IN
cord-290677-3gdcyrrz	166	24	appetite	appetite	NN
cord-290677-3gdcyrrz	166	25	.	.	.
cord-290677-3gdcyrrz	167	1	These	these	DT
cord-290677-3gdcyrrz	167	2	hypotheses	hypothesis	NNS
cord-290677-3gdcyrrz	167	3	could	could	MD
cord-290677-3gdcyrrz	167	4	be	be	VB
cord-290677-3gdcyrrz	167	5	tested	test	VBN
cord-290677-3gdcyrrz	167	6	experimentally	experimentally	RB
cord-290677-3gdcyrrz	167	7	using	use	VBG
cord-290677-3gdcyrrz	167	8	chemogenetic	chemogenetic	JJ
cord-290677-3gdcyrrz	167	9	and	and	CC
cord-290677-3gdcyrrz	167	10	optogenetic	optogenetic	JJ
cord-290677-3gdcyrrz	167	11	techniques	technique	NNS
cord-290677-3gdcyrrz	167	12	to	to	TO
cord-290677-3gdcyrrz	167	13	selectively	selectively	RB
cord-290677-3gdcyrrz	167	14	activate	activate	VB
cord-290677-3gdcyrrz	167	15	or	or	CC
cord-290677-3gdcyrrz	167	16	inhibit	inhibit	VB
cord-290677-3gdcyrrz	167	17	afferent	afferent	JJ
cord-290677-3gdcyrrz	167	18	or	or	CC
cord-290677-3gdcyrrz	167	19	efferent	efferent	JJ
cord-290677-3gdcyrrz	167	20	vagal	vagal	JJ
cord-290677-3gdcyrrz	167	21	tracts	tract	NNS
cord-290677-3gdcyrrz	167	22	and	and	CC
cord-290677-3gdcyrrz	167	23	examine	examine	VB
cord-290677-3gdcyrrz	167	24	whether	whether	IN
cord-290677-3gdcyrrz	167	25	this	this	DT
cord-290677-3gdcyrrz	167	26	modulation	modulation	NN
cord-290677-3gdcyrrz	167	27	affects	affect	VBZ
cord-290677-3gdcyrrz	167	28	immune	immune	NN
cord-290677-3gdcyrrz	167	29	-	-	HYPH
cord-290677-3gdcyrrz	167	30	dependent	dependent	JJ
cord-290677-3gdcyrrz	167	31	and	and	CC
cord-290677-3gdcyrrz	167	32	immune	immune	JJ
cord-290677-3gdcyrrz	167	33	-	-	HYPH
cord-290677-3gdcyrrz	167	34	independent	independent	JJ
cord-290677-3gdcyrrz	167	35	respiratory	respiratory	NN
cord-290677-3gdcyrrz	167	36	,	,	,
cord-290677-3gdcyrrz	167	37	cardiac	cardiac	JJ
cord-290677-3gdcyrrz	167	38	and	and	CC
cord-290677-3gdcyrrz	167	39	other	other	JJ
cord-290677-3gdcyrrz	167	40	autonomic	autonomic	JJ
cord-290677-3gdcyrrz	167	41	functions	function	NNS
cord-290677-3gdcyrrz	167	42	in	in	IN
cord-290677-3gdcyrrz	167	43	health	health	NN
cord-290677-3gdcyrrz	167	44	and	and	CC
cord-290677-3gdcyrrz	167	45	disease	disease	NN
cord-290677-3gdcyrrz	167	46	.	.	.
cord-290677-3gdcyrrz	168	1	In	in	IN
cord-290677-3gdcyrrz	168	2	line	line	NN
cord-290677-3gdcyrrz	168	3	with	with	IN
cord-290677-3gdcyrrz	168	4	our	-PRON-	PRP$
cord-290677-3gdcyrrz	168	5	NIU	NIU	NNP
cord-290677-3gdcyrrz	168	6	model	model	NN
cord-290677-3gdcyrrz	168	7	,	,	,
cord-290677-3gdcyrrz	168	8	therapeutic	therapeutic	JJ
cord-290677-3gdcyrrz	168	9	targeting	targeting	NN
cord-290677-3gdcyrrz	168	10	of	of	IN
cord-290677-3gdcyrrz	168	11	transient	transient	JJ
cord-290677-3gdcyrrz	168	12	receptor	receptor	NN
cord-290677-3gdcyrrz	168	13	potential	potential	JJ
cord-290677-3gdcyrrz	168	14	cation	cation	NN
cord-290677-3gdcyrrz	168	15	channel	channel	NN
cord-290677-3gdcyrrz	168	16	subfamily	subfamily	NN
cord-290677-3gdcyrrz	168	17	V	V	NNP
cord-290677-3gdcyrrz	168	18	member	member	NN
cord-290677-3gdcyrrz	168	19	1	1	CD
cord-290677-3gdcyrrz	168	20	(	(	-LRB-
cord-290677-3gdcyrrz	168	21	TRPV1)-expressing	trpv1)-expresse	VBG
cord-290677-3gdcyrrz	168	22	nerve	nerve	NN
cord-290677-3gdcyrrz	168	23	fibres	fibre	NNS
cord-290677-3gdcyrrz	168	24	in	in	IN
cord-290677-3gdcyrrz	168	25	the	the	DT
cord-290677-3gdcyrrz	168	26	lungs	lung	NNS
cord-290677-3gdcyrrz	168	27	,	,	,
cord-290677-3gdcyrrz	168	28	using	use	VBG
cord-290677-3gdcyrrz	168	29	the	the	DT
cord-290677-3gdcyrrz	168	30	TRPV1	TRPV1	NNP
cord-290677-3gdcyrrz	168	31	agonist	agonist	NN
cord-290677-3gdcyrrz	168	32	resiniferatoxin	resiniferatoxin	NNP
cord-290677-3gdcyrrz	168	33	,	,	,
cord-290677-3gdcyrrz	168	34	has	have	VBZ
cord-290677-3gdcyrrz	168	35	been	be	VBN
cord-290677-3gdcyrrz	168	36	suggested	suggest	VBN
cord-290677-3gdcyrrz	168	37	to	to	TO
cord-290677-3gdcyrrz	168	38	modulate	modulate	VB
cord-290677-3gdcyrrz	168	39	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	168	40	and	and	CC
cord-290677-3gdcyrrz	168	41	immune	immune	JJ
cord-290677-3gdcyrrz	168	42	signalling	signal	VBG
cord-290677-3gdcyrrz	168	43	activity	activity	NN
cord-290677-3gdcyrrz	168	44	,	,	,
cord-290677-3gdcyrrz	168	45	leading	lead	VBG
cord-290677-3gdcyrrz	168	46	to	to	IN
cord-290677-3gdcyrrz	168	47	reduced	reduce	VBN
cord-290677-3gdcyrrz	168	48	mortality	mortality	NN
cord-290677-3gdcyrrz	168	49	and	and	CC
cord-290677-3gdcyrrz	168	50	better	well	JJR
cord-290677-3gdcyrrz	168	51	overall	overall	JJ
cord-290677-3gdcyrrz	168	52	outcomes	outcome	NNS
cord-290677-3gdcyrrz	168	53	in	in	IN
cord-290677-3gdcyrrz	168	54	people	people	NNS
cord-290677-3gdcyrrz	168	55	with	with	IN
cord-290677-3gdcyrrz	168	56	COVID-19	COVID-19	NNP
cord-290677-3gdcyrrz	168	57	(	(	-LRB-
cord-290677-3gdcyrrz	168	58	ref	ref	NN
cord-290677-3gdcyrrz	168	59	.	.	.
cord-290677-3gdcyrrz	169	1	99	99	CD
cord-290677-3gdcyrrz	169	2	)	)	-RRB-
cord-290677-3gdcyrrz	169	3	.	.	.
cord-290677-3gdcyrrz	170	1	Although	although	IN
cord-290677-3gdcyrrz	170	2	this	this	DT
cord-290677-3gdcyrrz	170	3	approach	approach	NN
cord-290677-3gdcyrrz	170	4	seems	seem	VBZ
cord-290677-3gdcyrrz	170	5	promising	promising	JJ
cord-290677-3gdcyrrz	170	6	,	,	,
cord-290677-3gdcyrrz	170	7	several	several	JJ
cord-290677-3gdcyrrz	170	8	potential	potential	JJ
cord-290677-3gdcyrrz	170	9	downsides	downside	NNS
cord-290677-3gdcyrrz	170	10	need	need	VBP
cord-290677-3gdcyrrz	170	11	to	to	TO
cord-290677-3gdcyrrz	170	12	be	be	VB
cord-290677-3gdcyrrz	170	13	considered	consider	VBN
cord-290677-3gdcyrrz	170	14	.	.	.
cord-290677-3gdcyrrz	171	1	TRPV1	TRPV1	NNP
cord-290677-3gdcyrrz	171	2	is	be	VBZ
cord-290677-3gdcyrrz	171	3	expressed	express	VBN
cord-290677-3gdcyrrz	171	4	only	only	RB
cord-290677-3gdcyrrz	171	5	by	by	IN
cord-290677-3gdcyrrz	171	6	a	a	DT
cord-290677-3gdcyrrz	171	7	small	small	JJ
cord-290677-3gdcyrrz	171	8	subset	subset	NN
cord-290677-3gdcyrrz	171	9	of	of	IN
cord-290677-3gdcyrrz	171	10	chemoreceptor	chemoreceptor	NN
cord-290677-3gdcyrrz	171	11	fibres	fibre	NNS
cord-290677-3gdcyrrz	171	12	(	(	-LRB-
cord-290677-3gdcyrrz	171	13	the	the	DT
cord-290677-3gdcyrrz	171	14	C	C	NNP
cord-290677-3gdcyrrz	171	15	-	-	HYPH
cord-290677-3gdcyrrz	171	16	fibres	fibre	NNS
cord-290677-3gdcyrrz	171	17	)	)	-RRB-
cord-290677-3gdcyrrz	171	18	,	,	,
cord-290677-3gdcyrrz	171	19	but	but	CC
cord-290677-3gdcyrrz	171	20	the	the	DT
cord-290677-3gdcyrrz	171	21	majority	majority	NN
cord-290677-3gdcyrrz	171	22	of	of	IN
cord-290677-3gdcyrrz	171	23	afferent	afferent	JJ
cord-290677-3gdcyrrz	171	24	fibres	fibre	NNS
cord-290677-3gdcyrrz	171	25	innervating	innervate	VBG
cord-290677-3gdcyrrz	171	26	pulmonary	pulmonary	JJ
cord-290677-3gdcyrrz	171	27	structures	structure	NNS
cord-290677-3gdcyrrz	171	28	are	be	VBP
cord-290677-3gdcyrrz	171	29	carried	carry	VBN
cord-290677-3gdcyrrz	171	30	by	by	IN
cord-290677-3gdcyrrz	171	31	vagal	vagal	JJ
cord-290677-3gdcyrrz	171	32	or	or	CC
cord-290677-3gdcyrrz	171	33	dorsal	dorsal	JJ
cord-290677-3gdcyrrz	171	34	root	root	NN
cord-290677-3gdcyrrz	171	35	ganglion	ganglion	NN
cord-290677-3gdcyrrz	171	36	fibres	fibre	NNS
cord-290677-3gdcyrrz	171	37	from	from	IN
cord-290677-3gdcyrrz	171	38	the	the	DT
cord-290677-3gdcyrrz	171	39	upper	upper	JJ
cord-290677-3gdcyrrz	171	40	thoracic	thoracic	JJ
cord-290677-3gdcyrrz	171	41	segments	segment	NNS
cord-290677-3gdcyrrz	171	42	.	.	.
cord-290677-3gdcyrrz	172	1	In	in	IN
cord-290677-3gdcyrrz	172	2	addition	addition	NN
cord-290677-3gdcyrrz	172	3	,	,	,
cord-290677-3gdcyrrz	172	4	resiniferatoxin	resiniferatoxin	NNP
cord-290677-3gdcyrrz	172	5	is	be	VBZ
cord-290677-3gdcyrrz	172	6	an	an	DT
cord-290677-3gdcyrrz	172	7	ultra	ultra	JJ
cord-290677-3gdcyrrz	172	8	-	-	JJ
cord-290677-3gdcyrrz	172	9	potent	potent	JJ
cord-290677-3gdcyrrz	172	10	agonist	agonist	NN
cord-290677-3gdcyrrz	172	11	that	that	WDT
cord-290677-3gdcyrrz	172	12	binds	bind	VBZ
cord-290677-3gdcyrrz	172	13	to	to	IN
cord-290677-3gdcyrrz	172	14	and	and	CC
cord-290677-3gdcyrrz	172	15	forces	force	VBZ
cord-290677-3gdcyrrz	172	16	the	the	DT
cord-290677-3gdcyrrz	172	17	opening	opening	NN
cord-290677-3gdcyrrz	172	18	of	of	IN
cord-290677-3gdcyrrz	172	19	the	the	DT
cord-290677-3gdcyrrz	172	20	TRPV1	TRPV1	NNP
cord-290677-3gdcyrrz	172	21	channel	channel	NN
cord-290677-3gdcyrrz	172	22	,	,	,
cord-290677-3gdcyrrz	172	23	leading	lead	VBG
cord-290677-3gdcyrrz	172	24	to	to	IN
cord-290677-3gdcyrrz	172	25	a	a	DT
cord-290677-3gdcyrrz	172	26	sustained	sustained	JJ
cord-290677-3gdcyrrz	172	27	increase	increase	NN
cord-290677-3gdcyrrz	172	28	in	in	IN
cord-290677-3gdcyrrz	172	29	intracellular	intracellular	JJ
cord-290677-3gdcyrrz	172	30	calcium	calcium	NN
cord-290677-3gdcyrrz	172	31	levels	level	NNS
cord-290677-3gdcyrrz	172	32	100	100	CD
cord-290677-3gdcyrrz	172	33	.	.	.
cord-290677-3gdcyrrz	173	1	This	this	DT
cord-290677-3gdcyrrz	173	2	,	,	,
cord-290677-3gdcyrrz	173	3	in	in	IN
cord-290677-3gdcyrrz	173	4	turns	turn	NNS
cord-290677-3gdcyrrz	173	5	,	,	,
cord-290677-3gdcyrrz	173	6	disrupts	disrupt	VBZ
cord-290677-3gdcyrrz	173	7	mitochondrial	mitochondrial	JJ
cord-290677-3gdcyrrz	173	8	metabolism	metabolism	NN
cord-290677-3gdcyrrz	173	9	and	and	CC
cord-290677-3gdcyrrz	173	10	results	result	NNS
cord-290677-3gdcyrrz	173	11	in	in	IN
cord-290677-3gdcyrrz	173	12	permanent	permanent	JJ
cord-290677-3gdcyrrz	173	13	neurolysis	neurolysis	NN
cord-290677-3gdcyrrz	173	14	,	,	,
cord-290677-3gdcyrrz	173	15	making	make	VBG
cord-290677-3gdcyrrz	173	16	this	this	DT
cord-290677-3gdcyrrz	173	17	drug	drug	NN
cord-290677-3gdcyrrz	173	18	potentially	potentially	RB
cord-290677-3gdcyrrz	173	19	toxic	toxic	JJ
cord-290677-3gdcyrrz	173	20	for	for	IN
cord-290677-3gdcyrrz	173	21	nerve	nerve	NN
cord-290677-3gdcyrrz	173	22	cells	cell	NNS
cord-290677-3gdcyrrz	173	23	and	and	CC
cord-290677-3gdcyrrz	173	24	pulmonary	pulmonary	JJ
cord-290677-3gdcyrrz	173	25	neuroimmune	neuroimmune	NN
cord-290677-3gdcyrrz	173	26	homeostasis	homeostasis	NN
cord-290677-3gdcyrrz	173	27	.	.	.
cord-290677-3gdcyrrz	174	1	Another	another	DT
cord-290677-3gdcyrrz	174	2	potentially	potentially	RB
cord-290677-3gdcyrrz	174	3	interesting	interesting	JJ
cord-290677-3gdcyrrz	174	4	unexplored	unexplored	JJ
cord-290677-3gdcyrrz	174	5	target	target	NN
cord-290677-3gdcyrrz	174	6	is	be	VBZ
cord-290677-3gdcyrrz	174	7	the	the	DT
cord-290677-3gdcyrrz	174	8	neuropeptide	neuropeptide	NN
cord-290677-3gdcyrrz	174	9	CGRP	CGRP	NNP
cord-290677-3gdcyrrz	174	10	.	.	.
cord-290677-3gdcyrrz	175	1	CGRP	CGRP	NNP
cord-290677-3gdcyrrz	175	2	antagonism	antagonism	NN
cord-290677-3gdcyrrz	175	3	could	could	MD
cord-290677-3gdcyrrz	175	4	limit	limit	VB
cord-290677-3gdcyrrz	175	5	bronchoconstriction	bronchoconstriction	NN
cord-290677-3gdcyrrz	175	6	and	and	CC
cord-290677-3gdcyrrz	175	7	vasodilation	vasodilation	NN
cord-290677-3gdcyrrz	175	8	and	and	CC
cord-290677-3gdcyrrz	175	9	limit	limit	VB
cord-290677-3gdcyrrz	175	10	the	the	DT
cord-290677-3gdcyrrz	175	11	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	175	12	response	response	NN
cord-290677-3gdcyrrz	175	13	62	62	CD
cord-290677-3gdcyrrz	175	14	,	,	,
cord-290677-3gdcyrrz	175	15	and	and	CC
cord-290677-3gdcyrrz	175	16	the	the	DT
cord-290677-3gdcyrrz	175	17	recent	recent	JJ
cord-290677-3gdcyrrz	175	18	development	development	NN
cord-290677-3gdcyrrz	175	19	and	and	CC
cord-290677-3gdcyrrz	175	20	commercialization	commercialization	NN
cord-290677-3gdcyrrz	175	21	of	of	IN
cord-290677-3gdcyrrz	175	22	anti	anti	JJ
cord-290677-3gdcyrrz	175	23	-	-	JJ
cord-290677-3gdcyrrz	175	24	CGRP	cgrp	JJ
cord-290677-3gdcyrrz	175	25	and	and	CC
cord-290677-3gdcyrrz	175	26	anti	anti	JJ
cord-290677-3gdcyrrz	175	27	-	-	JJ
cord-290677-3gdcyrrz	175	28	CGRP	cgrp	JJ
cord-290677-3gdcyrrz	175	29	receptor	receptor	NN
cord-290677-3gdcyrrz	175	30	monoclonal	monoclonal	JJ
cord-290677-3gdcyrrz	175	31	antibodies	antibody	NNS
cord-290677-3gdcyrrz	175	32	for	for	IN
cord-290677-3gdcyrrz	175	33	the	the	DT
cord-290677-3gdcyrrz	175	34	treatment	treatment	NN
cord-290677-3gdcyrrz	175	35	of	of	IN
cord-290677-3gdcyrrz	175	36	migraine	migraine	NN
cord-290677-3gdcyrrz	175	37	might	may	MD
cord-290677-3gdcyrrz	175	38	enable	enable	VB
cord-290677-3gdcyrrz	175	39	fast	fast	JJ
cord-290677-3gdcyrrz	175	40	repurposing	repurposing	NN
cord-290677-3gdcyrrz	175	41	for	for	IN
cord-290677-3gdcyrrz	175	42	ARDS	ARDS	NNP
cord-290677-3gdcyrrz	175	43	.	.	.
cord-290677-3gdcyrrz	176	1	Similarly	similarly	RB
cord-290677-3gdcyrrz	176	2	,	,	,
cord-290677-3gdcyrrz	176	3	neurokinin	neurokinin	NNP
cord-290677-3gdcyrrz	176	4	A	a	DT
cord-290677-3gdcyrrz	176	5	receptor	receptor	NN
cord-290677-3gdcyrrz	176	6	antagonists	antagonist	NNS
cord-290677-3gdcyrrz	176	7	,	,	,
cord-290677-3gdcyrrz	176	8	which	which	WDT
cord-290677-3gdcyrrz	176	9	antagonize	antagonize	VBP
cord-290677-3gdcyrrz	176	10	the	the	DT
cord-290677-3gdcyrrz	176	11	binding	binding	NN
cord-290677-3gdcyrrz	176	12	of	of	IN
cord-290677-3gdcyrrz	176	13	both	both	DT
cord-290677-3gdcyrrz	176	14	neurokinin	neurokinin	NNS
cord-290677-3gdcyrrz	176	15	A	A	NNP
cord-290677-3gdcyrrz	176	16	and	and	CC
cord-290677-3gdcyrrz	176	17	the	the	DT
cord-290677-3gdcyrrz	176	18	closely	closely	RB
cord-290677-3gdcyrrz	176	19	related	related	JJ
cord-290677-3gdcyrrz	176	20	substance	substance	NN
cord-290677-3gdcyrrz	176	21	P	p	NN
cord-290677-3gdcyrrz	176	22	,	,	,
cord-290677-3gdcyrrz	176	23	have	have	VBP
cord-290677-3gdcyrrz	176	24	been	be	VBN
cord-290677-3gdcyrrz	176	25	developed	develop	VBN
cord-290677-3gdcyrrz	176	26	for	for	IN
cord-290677-3gdcyrrz	176	27	clinical	clinical	JJ
cord-290677-3gdcyrrz	176	28	use	use	NN
cord-290677-3gdcyrrz	176	29	against	against	IN
cord-290677-3gdcyrrz	176	30	nausea	nausea	NN
cord-290677-3gdcyrrz	176	31	and	and	CC
cord-290677-3gdcyrrz	176	32	vomiting	vomit	VBG
cord-290677-3gdcyrrz	176	33	following	follow	VBG
cord-290677-3gdcyrrz	176	34	surgery	surgery	NN
cord-290677-3gdcyrrz	176	35	and	and	CC
cord-290677-3gdcyrrz	176	36	chemotherapy	chemotherapy	NN
cord-290677-3gdcyrrz	176	37	101	101	CD
cord-290677-3gdcyrrz	176	38	,	,	,
cord-290677-3gdcyrrz	176	39	102	102	CD
cord-290677-3gdcyrrz	176	40	,	,	,
cord-290677-3gdcyrrz	176	41	and	and	CC
cord-290677-3gdcyrrz	176	42	could	could	MD
cord-290677-3gdcyrrz	176	43	be	be	VB
cord-290677-3gdcyrrz	176	44	repurposed	repurpose	VBN
cord-290677-3gdcyrrz	176	45	to	to	TO
cord-290677-3gdcyrrz	176	46	counteract	counteract	VB
cord-290677-3gdcyrrz	176	47	lung	lung	NN
cord-290677-3gdcyrrz	176	48	inflammation	inflammation	NN
cord-290677-3gdcyrrz	176	49	and	and	CC
cord-290677-3gdcyrrz	176	50	bronchoconstriction	bronchoconstriction	NN
cord-290677-3gdcyrrz	176	51	in	in	IN
cord-290677-3gdcyrrz	176	52	people	people	NNS
cord-290677-3gdcyrrz	176	53	with	with	IN
cord-290677-3gdcyrrz	176	54	COVID-19	COVID-19	NNP
cord-290677-3gdcyrrz	176	55	.	.	.
cord-290677-3gdcyrrz	177	1	Nausea	nausea	NN
cord-290677-3gdcyrrz	177	2	and	and	CC
cord-290677-3gdcyrrz	177	3	vomiting	vomiting	NN
cord-290677-3gdcyrrz	177	4	,	,	,
cord-290677-3gdcyrrz	177	5	which	which	WDT
cord-290677-3gdcyrrz	177	6	are	be	VBP
cord-290677-3gdcyrrz	177	7	controlled	control	VBN
cord-290677-3gdcyrrz	177	8	by	by	IN
cord-290677-3gdcyrrz	177	9	the	the	DT
cord-290677-3gdcyrrz	177	10	area	area	NN
cord-290677-3gdcyrrz	177	11	postrema	postrema	NN
cord-290677-3gdcyrrz	177	12	,	,	,
cord-290677-3gdcyrrz	177	13	NTS	NTS	NNP
cord-290677-3gdcyrrz	177	14	and	and	CC
cord-290677-3gdcyrrz	177	15	dorsal	dorsal	JJ
cord-290677-3gdcyrrz	177	16	motor	motor	NN
cord-290677-3gdcyrrz	177	17	nucleus	nucleus	NN
cord-290677-3gdcyrrz	177	18	of	of	IN
cord-290677-3gdcyrrz	177	19	the	the	DT
cord-290677-3gdcyrrz	177	20	vagus	vagus	NN
cord-290677-3gdcyrrz	177	21	,	,	,
cord-290677-3gdcyrrz	177	22	have	have	VBP
cord-290677-3gdcyrrz	177	23	also	also	RB
cord-290677-3gdcyrrz	177	24	been	be	VBN
cord-290677-3gdcyrrz	177	25	reported	report	VBN
cord-290677-3gdcyrrz	177	26	in	in	IN
cord-290677-3gdcyrrz	177	27	patients	patient	NNS
cord-290677-3gdcyrrz	177	28	with	with	IN
cord-290677-3gdcyrrz	177	29	COVID-19	COVID-19	NNP
cord-290677-3gdcyrrz	177	30	and	and	CC
cord-290677-3gdcyrrz	177	31	could	could	MD
cord-290677-3gdcyrrz	177	32	potentially	potentially	RB
cord-290677-3gdcyrrz	177	33	be	be	VB
cord-290677-3gdcyrrz	177	34	treated	treat	VBN
cord-290677-3gdcyrrz	177	35	with	with	IN
cord-290677-3gdcyrrz	177	36	neurokinin	neurokinin	NNP
cord-290677-3gdcyrrz	177	37	A	a	DT
cord-290677-3gdcyrrz	177	38	receptor	receptor	NN
cord-290677-3gdcyrrz	177	39	antagonists	antagonist	NNS
cord-290677-3gdcyrrz	177	40	.	.	.
cord-290677-3gdcyrrz	178	1	Additional	additional	JJ
cord-290677-3gdcyrrz	178	2	drugs	drug	NNS
cord-290677-3gdcyrrz	178	3	that	that	WDT
cord-290677-3gdcyrrz	178	4	specifically	specifically	RB
cord-290677-3gdcyrrz	178	5	modulate	modulate	VBP
cord-290677-3gdcyrrz	178	6	the	the	DT
cord-290677-3gdcyrrz	178	7	NIU	NIU	NNP
cord-290677-3gdcyrrz	178	8	,	,	,
cord-290677-3gdcyrrz	178	9	such	such	JJ
cord-290677-3gdcyrrz	178	10	as	as	IN
cord-290677-3gdcyrrz	178	11	bombesin	bombesin	NNP
cord-290677-3gdcyrrz	178	12	antagonists	antagonist	NNS
cord-290677-3gdcyrrz	178	13	,	,	,
cord-290677-3gdcyrrz	178	14	might	may	MD
cord-290677-3gdcyrrz	178	15	be	be	VB
cord-290677-3gdcyrrz	178	16	developed	develop	VBN
cord-290677-3gdcyrrz	178	17	to	to	TO
cord-290677-3gdcyrrz	178	18	improve	improve	VB
cord-290677-3gdcyrrz	178	19	clinical	clinical	JJ
cord-290677-3gdcyrrz	178	20	outcomes	outcome	NNS
cord-290677-3gdcyrrz	178	21	in	in	IN
cord-290677-3gdcyrrz	178	22	patients	patient	NNS
cord-290677-3gdcyrrz	178	23	with	with	IN
cord-290677-3gdcyrrz	178	24	COVID-19	COVID-19	NNP
cord-290677-3gdcyrrz	178	25	and	and	CC
cord-290677-3gdcyrrz	178	26	could	could	MD
cord-290677-3gdcyrrz	178	27	also	also	RB
cord-290677-3gdcyrrz	178	28	be	be	VB
cord-290677-3gdcyrrz	178	29	tested	test	VBN
cord-290677-3gdcyrrz	178	30	in	in	IN
cord-290677-3gdcyrrz	178	31	a	a	DT
cord-290677-3gdcyrrz	178	32	broader	broad	JJR
cord-290677-3gdcyrrz	178	33	range	range	NN
cord-290677-3gdcyrrz	178	34	of	of	IN
cord-290677-3gdcyrrz	178	35	neuroimmune	neuroimmune	NNP
cord-290677-3gdcyrrz	178	36	diseases	disease	NNS
cord-290677-3gdcyrrz	178	37	.	.	.
cord-290677-3gdcyrrz	179	1	In	in	IN
cord-290677-3gdcyrrz	179	2	conclusion	conclusion	NN
cord-290677-3gdcyrrz	179	3	,	,	,
cord-290677-3gdcyrrz	179	4	the	the	DT
cord-290677-3gdcyrrz	179	5	integrated	integrate	VBN
cord-290677-3gdcyrrz	179	6	NIU	NIU	NNP
cord-290677-3gdcyrrz	179	7	model	model	NN
cord-290677-3gdcyrrz	179	8	that	that	IN
cord-290677-3gdcyrrz	179	9	we	-PRON-	PRP
cord-290677-3gdcyrrz	179	10	have	have	VBP
cord-290677-3gdcyrrz	179	11	proposed	propose	VBN
cord-290677-3gdcyrrz	179	12	suggests	suggest	VBZ
cord-290677-3gdcyrrz	179	13	novel	novel	JJ
cord-290677-3gdcyrrz	179	14	strategies	strategy	NNS
cord-290677-3gdcyrrz	179	15	for	for	IN
cord-290677-3gdcyrrz	179	16	the	the	DT
cord-290677-3gdcyrrz	179	17	development	development	NN
cord-290677-3gdcyrrz	179	18	of	of	IN
cord-290677-3gdcyrrz	179	19	targeted	target	VBN
cord-290677-3gdcyrrz	179	20	and	and	CC
cord-290677-3gdcyrrz	179	21	effective	effective	JJ
cord-290677-3gdcyrrz	179	22	treatments	treatment	NNS
cord-290677-3gdcyrrz	179	23	that	that	WDT
cord-290677-3gdcyrrz	179	24	could	could	MD
cord-290677-3gdcyrrz	179	25	ameliorate	ameliorate	VB
cord-290677-3gdcyrrz	179	26	the	the	DT
cord-290677-3gdcyrrz	179	27	symptoms	symptom	NNS
cord-290677-3gdcyrrz	179	28	and	and	CC
cord-290677-3gdcyrrz	179	29	mitigate	mitigate	VB
cord-290677-3gdcyrrz	179	30	the	the	DT
cord-290677-3gdcyrrz	179	31	life	life	NN
cord-290677-3gdcyrrz	179	32	-	-	HYPH
cord-290677-3gdcyrrz	179	33	threatening	threaten	VBG
cord-290677-3gdcyrrz	179	34	consequences	consequence	NNS
cord-290677-3gdcyrrz	179	35	of	of	IN
cord-290677-3gdcyrrz	179	36	SARS	SARS	NNP
cord-290677-3gdcyrrz	179	37	-	-	HYPH
cord-290677-3gdcyrrz	179	38	CoV-2	CoV-2	NNP
cord-290677-3gdcyrrz	179	39	infection	infection	NN
cord-290677-3gdcyrrz	179	40	.	.	.
cord-290677-3gdcyrrz	180	1	A	a	DT
cord-290677-3gdcyrrz	180	2	strategic	strategic	JJ
cord-290677-3gdcyrrz	180	3	roadmap	roadmap	NN
cord-290677-3gdcyrrz	180	4	for	for	IN
cord-290677-3gdcyrrz	180	5	further	further	JJ
cord-290677-3gdcyrrz	180	6	research	research	NN
cord-290677-3gdcyrrz	180	7	and	and	CC
cord-290677-3gdcyrrz	180	8	therapeutic	therapeutic	JJ
cord-290677-3gdcyrrz	180	9	development	development	NN
cord-290677-3gdcyrrz	180	10	is	be	VBZ
cord-290677-3gdcyrrz	180	11	provided	provide	VBN
cord-290677-3gdcyrrz	180	12	in	in	IN
cord-290677-3gdcyrrz	180	13	fig	fig	NN
cord-290677-3gdcyrrz	180	14	.	.	.
cord-290677-3gdcyrrz	181	1	3	3	LS
cord-290677-3gdcyrrz	181	2	.	.	.
cord-290677-3gdcyrrz	182	1	In	in	IN
cord-290677-3gdcyrrz	182	2	the	the	DT
cord-290677-3gdcyrrz	182	3	long	long	JJ
cord-290677-3gdcyrrz	182	4	term	term	NN
cord-290677-3gdcyrrz	182	5	,	,	,
cord-290677-3gdcyrrz	182	6	this	this	DT
cord-290677-3gdcyrrz	182	7	model	model	NN
cord-290677-3gdcyrrz	182	8	might	may	MD
cord-290677-3gdcyrrz	182	9	also	also	RB
cord-290677-3gdcyrrz	182	10	provide	provide	VB
cord-290677-3gdcyrrz	182	11	a	a	DT
cord-290677-3gdcyrrz	182	12	new	new	JJ
cord-290677-3gdcyrrz	182	13	perspective	perspective	NN
cord-290677-3gdcyrrz	182	14	for	for	IN
cord-290677-3gdcyrrz	182	15	the	the	DT
cord-290677-3gdcyrrz	182	16	discovery	discovery	NN
cord-290677-3gdcyrrz	182	17	of	of	IN
cord-290677-3gdcyrrz	182	18	effective	effective	JJ
cord-290677-3gdcyrrz	182	19	therapies	therapy	NNS
cord-290677-3gdcyrrz	182	20	for	for	IN
cord-290677-3gdcyrrz	182	21	a	a	DT
cord-290677-3gdcyrrz	182	22	broad	broad	JJ
cord-290677-3gdcyrrz	182	23	range	range	NN
cord-290677-3gdcyrrz	182	24	of	of	IN
cord-290677-3gdcyrrz	182	25	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	182	26	and	and	CC
cord-290677-3gdcyrrz	182	27	infectious	infectious	JJ
cord-290677-3gdcyrrz	182	28	diseases	disease	NNS
cord-290677-3gdcyrrz	182	29	and	and	CC
cord-290677-3gdcyrrz	182	30	the	the	DT
cord-290677-3gdcyrrz	182	31	discovery	discovery	NN
cord-290677-3gdcyrrz	182	32	of	of	IN
cord-290677-3gdcyrrz	182	33	potentially	potentially	RB
cord-290677-3gdcyrrz	182	34	novel	novel	JJ
cord-290677-3gdcyrrz	182	35	biological	biological	JJ
cord-290677-3gdcyrrz	182	36	phenomena	phenomenon	NNS
cord-290677-3gdcyrrz	182	37	.	.	.
cord-290677-3gdcyrrz	183	1	Fig	Fig	NNP
cord-290677-3gdcyrrz	183	2	.	.	.
cord-290677-3gdcyrrz	184	1	3	3	LS
cord-290677-3gdcyrrz	184	2	|	|	NFP
cord-290677-3gdcyrrz	184	3	Studying	study	VBG
cord-290677-3gdcyrrz	184	4	the	the	DT
cord-290677-3gdcyrrz	184	5	neuroimmune	neuroimmune	NNP
cord-290677-3gdcyrrz	184	6	unit	unit	NN
cord-290677-3gdcyrrz	184	7	:	:	:
cord-290677-3gdcyrrz	184	8	a	a	DT
cord-290677-3gdcyrrz	184	9	roadmap	roadmap	NN
cord-290677-3gdcyrrz	184	10	.	.	.
cord-290677-3gdcyrrz	185	1	The	the	DT
cord-290677-3gdcyrrz	185	2	diagram	diagram	NN
cord-290677-3gdcyrrz	185	3	depicts	depict	VBZ
cord-290677-3gdcyrrz	185	4	a	a	DT
cord-290677-3gdcyrrz	185	5	stepwise	stepwise	JJ
cord-290677-3gdcyrrz	185	6	roadmap	roadmap	NN
cord-290677-3gdcyrrz	185	7	to	to	TO
cord-290677-3gdcyrrz	185	8	increase	increase	VB
cord-290677-3gdcyrrz	185	9	our	-PRON-	PRP$
cord-290677-3gdcyrrz	185	10	understanding	understanding	NN
cord-290677-3gdcyrrz	185	11	of	of	IN
cord-290677-3gdcyrrz	185	12	the	the	DT
cord-290677-3gdcyrrz	185	13	neuroimmune	neuroimmune	NNP
cord-290677-3gdcyrrz	185	14	unit	unit	NN
cord-290677-3gdcyrrz	185	15	and	and	CC
cord-290677-3gdcyrrz	185	16	the	the	DT
cord-290677-3gdcyrrz	185	17	potential	potential	JJ
cord-290677-3gdcyrrz	185	18	discovery	discovery	NN
cord-290677-3gdcyrrz	185	19	of	of	IN
cord-290677-3gdcyrrz	185	20	pharmacological	pharmacological	JJ
cord-290677-3gdcyrrz	185	21	,	,	,
cord-290677-3gdcyrrz	185	22	genetic	genetic	JJ
cord-290677-3gdcyrrz	185	23	and	and	CC
cord-290677-3gdcyrrz	185	24	physiological	physiological	JJ
cord-290677-3gdcyrrz	185	25	treatments	treatment	NNS
cord-290677-3gdcyrrz	185	26	that	that	WDT
cord-290677-3gdcyrrz	185	27	could	could	MD
cord-290677-3gdcyrrz	185	28	be	be	VB
cord-290677-3gdcyrrz	185	29	used	use	VBN
cord-290677-3gdcyrrz	185	30	in	in	IN
cord-290677-3gdcyrrz	185	31	the	the	DT
cord-290677-3gdcyrrz	185	32	clinic	clinic	NN
cord-290677-3gdcyrrz	185	33	.	.	.
cord-290677-3gdcyrrz	186	1	CGRP	CGRP	NNP
cord-290677-3gdcyrrz	186	2	,	,	,
cord-290677-3gdcyrrz	186	3	calcitonin	calcitonin	NN
cord-290677-3gdcyrrz	186	4	gene	gene	NN
cord-290677-3gdcyrrz	186	5	-	-	HYPH
cord-290677-3gdcyrrz	186	6	related	relate	VBN
cord-290677-3gdcyrrz	186	7	peptide	peptide	NN
cord-290677-3gdcyrrz	186	8	.	.	.
cord-290677-3gdcyrrz	187	1	www.nature.com/nrneurol	www.nature.com/nrneurol	JJ
cord-290677-3gdcyrrz	188	1	Clinical	clinical	JJ
cord-290677-3gdcyrrz	188	2	features	feature	NNS
cord-290677-3gdcyrrz	188	3	of	of	IN
cord-290677-3gdcyrrz	188	4	patients	patient	NNS
cord-290677-3gdcyrrz	188	5	infected	infect	VBN
cord-290677-3gdcyrrz	188	6	with	with	IN
cord-290677-3gdcyrrz	188	7	2019	2019	CD
cord-290677-3gdcyrrz	188	8	novel	novel	JJ
cord-290677-3gdcyrrz	188	9	coronavirus	coronavirus	NN
cord-290677-3gdcyrrz	188	10	in	in	IN
cord-290677-3gdcyrrz	188	11	Wuhan	Wuhan	NNP
cord-290677-3gdcyrrz	188	12	A	a	DT
cord-290677-3gdcyrrz	188	13	pneumonia	pneumonia	NN
cord-290677-3gdcyrrz	188	14	outbreak	outbreak	NN
cord-290677-3gdcyrrz	188	15	associated	associate	VBN
cord-290677-3gdcyrrz	188	16	with	with	IN
cord-290677-3gdcyrrz	188	17	a	a	DT
cord-290677-3gdcyrrz	188	18	new	new	JJ
cord-290677-3gdcyrrz	188	19	coronavirus	coronavirus	NN
cord-290677-3gdcyrrz	188	20	of	of	IN
cord-290677-3gdcyrrz	188	21	probable	probable	JJ
cord-290677-3gdcyrrz	188	22	bat	bat	NN
cord-290677-3gdcyrrz	189	1	origin	origin	NNP
cord-290677-3gdcyrrz	189	2	CoV-2	CoV-2	NNP
cord-290677-3gdcyrrz	189	3	:	:	:
cord-290677-3gdcyrrz	189	4	olfaction	olfaction	NN
cord-290677-3gdcyrrz	189	5	,	,	,
cord-290677-3gdcyrrz	189	6	brain	brain	NN
cord-290677-3gdcyrrz	189	7	infection	infection	NN
cord-290677-3gdcyrrz	189	8	,	,	,
cord-290677-3gdcyrrz	189	9	and	and	CC
cord-290677-3gdcyrrz	189	10	the	the	DT
cord-290677-3gdcyrrz	189	11	urgent	urgent	JJ
cord-290677-3gdcyrrz	189	12	need	need	NN
cord-290677-3gdcyrrz	189	13	for	for	IN
cord-290677-3gdcyrrz	189	14	clinical	clinical	JJ
cord-290677-3gdcyrrz	189	15	samples	sample	NNS
cord-290677-3gdcyrrz	189	16	allowing	allow	VBG
cord-290677-3gdcyrrz	189	17	earlier	early	JJR
cord-290677-3gdcyrrz	189	18	virus	virus	NN
cord-290677-3gdcyrrz	189	19	detection	detection	NN
cord-290677-3gdcyrrz	189	20	Concomitant	concomitant	JJ
cord-290677-3gdcyrrz	189	21	neurological	neurological	JJ
cord-290677-3gdcyrrz	189	22	symptoms	symptom	NNS
cord-290677-3gdcyrrz	189	23	observed	observe	VBN
cord-290677-3gdcyrrz	189	24	in	in	IN
cord-290677-3gdcyrrz	189	25	a	a	DT
cord-290677-3gdcyrrz	189	26	patient	patient	NN
cord-290677-3gdcyrrz	189	27	diagnosed	diagnose	VBN
cord-290677-3gdcyrrz	189	28	with	with	IN
cord-290677-3gdcyrrz	189	29	coronavirus	coronavirus	NN
cord-290677-3gdcyrrz	189	30	disease	disease	NN
cord-290677-3gdcyrrz	189	31	2019	2019	CD
cord-290677-3gdcyrrz	189	32	Neurologic	neurologic	JJ
cord-290677-3gdcyrrz	189	33	manifestations	manifestation	NNS
cord-290677-3gdcyrrz	189	34	of	of	IN
cord-290677-3gdcyrrz	189	35	hospitalized	hospitalize	VBN
cord-290677-3gdcyrrz	189	36	patients	patient	NNS
cord-290677-3gdcyrrz	189	37	with	with	IN
cord-290677-3gdcyrrz	189	38	coronavirus	coronavirus	NN
cord-290677-3gdcyrrz	189	39	disease	disease	NN
cord-290677-3gdcyrrz	189	40	Involvement	Involvement	NNP
cord-290677-3gdcyrrz	189	41	of	of	IN
cord-290677-3gdcyrrz	189	42	the	the	DT
cord-290677-3gdcyrrz	189	43	nervous	nervous	JJ
cord-290677-3gdcyrrz	189	44	system	system	NN
cord-290677-3gdcyrrz	189	45	in	in	IN
cord-290677-3gdcyrrz	189	46	SARS	SARS	NNP
cord-290677-3gdcyrrz	189	47	-	-	HYPH
cord-290677-3gdcyrrz	189	48	CoV-2	CoV-2	NNP
cord-290677-3gdcyrrz	189	49	infection	infection	NN
cord-290677-3gdcyrrz	189	50	Psychiatric	psychiatric	JJ
cord-290677-3gdcyrrz	189	51	and	and	CC
cord-290677-3gdcyrrz	189	52	neuropsychiatric	neuropsychiatric	JJ
cord-290677-3gdcyrrz	189	53	presentations	presentation	NNS
cord-290677-3gdcyrrz	189	54	associated	associate	VBN
cord-290677-3gdcyrrz	189	55	with	with	IN
cord-290677-3gdcyrrz	189	56	severe	severe	JJ
cord-290677-3gdcyrrz	189	57	coronavirus	coronavirus	NN
cord-290677-3gdcyrrz	189	58	infections	infection	NNS
cord-290677-3gdcyrrz	189	59	:	:	:
cord-290677-3gdcyrrz	189	60	a	a	DT
cord-290677-3gdcyrrz	189	61	systematic	systematic	JJ
cord-290677-3gdcyrrz	189	62	review	review	NN
cord-290677-3gdcyrrz	189	63	and	and	CC
cord-290677-3gdcyrrz	189	64	meta	meta	NNP
cord-290677-3gdcyrrz	189	65	-	-	HYPH
cord-290677-3gdcyrrz	189	66	analysis	analysis	NN
cord-290677-3gdcyrrz	189	67	with	with	IN
cord-290677-3gdcyrrz	189	68	comparison	comparison	NN
cord-290677-3gdcyrrz	189	69	to	to	IN
cord-290677-3gdcyrrz	189	70	the	the	DT
cord-290677-3gdcyrrz	189	71	COVID-19	COVID-19	NNP
cord-290677-3gdcyrrz	189	72	pandemic	pandemic	NN
cord-290677-3gdcyrrz	189	73	Severe	severe	JJ
cord-290677-3gdcyrrz	189	74	acute	acute	JJ
cord-290677-3gdcyrrz	189	75	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	189	76	syndrome	syndrome	NN
cord-290677-3gdcyrrz	189	77	coronavirus	coronavirus	NN
cord-290677-3gdcyrrz	189	78	2	2	CD
cord-290677-3gdcyrrz	189	79	(	(	-LRB-
cord-290677-3gdcyrrz	189	80	SARS	SARS	NNP
cord-290677-3gdcyrrz	189	81	-	-	HYPH
cord-290677-3gdcyrrz	189	82	CoV-2	CoV-2	NNP
cord-290677-3gdcyrrz	189	83	)	)	-RRB-
cord-290677-3gdcyrrz	189	84	and	and	CC
cord-290677-3gdcyrrz	189	85	the	the	DT
cord-290677-3gdcyrrz	189	86	central	central	JJ
cord-290677-3gdcyrrz	189	87	nervous	nervous	JJ
cord-290677-3gdcyrrz	189	88	system	system	NN
cord-290677-3gdcyrrz	189	89	Tissue	tissue	NN
cord-290677-3gdcyrrz	189	90	distribution	distribution	NN
cord-290677-3gdcyrrz	189	91	of	of	IN
cord-290677-3gdcyrrz	189	92	ACE2	ACE2	NNP
cord-290677-3gdcyrrz	189	93	protein	protein	NN
cord-290677-3gdcyrrz	189	94	,	,	,
cord-290677-3gdcyrrz	189	95	the	the	DT
cord-290677-3gdcyrrz	189	96	functional	functional	JJ
cord-290677-3gdcyrrz	189	97	receptor	receptor	NN
cord-290677-3gdcyrrz	189	98	for	for	IN
cord-290677-3gdcyrrz	189	99	SARS	SARS	NNP
cord-290677-3gdcyrrz	189	100	coronavirus	coronavirus	NN
cord-290677-3gdcyrrz	189	101	.	.	.
cord-290677-3gdcyrrz	190	1	A	a	DT
cord-290677-3gdcyrrz	190	2	first	first	JJ
cord-290677-3gdcyrrz	190	3	step	step	NN
cord-290677-3gdcyrrz	190	4	in	in	IN
cord-290677-3gdcyrrz	190	5	understanding	understand	VBG
cord-290677-3gdcyrrz	190	6	SARS	SARS	NNP
cord-290677-3gdcyrrz	190	7	pathogenesis	pathogenesis	NN
cord-290677-3gdcyrrz	190	8	SARS	SARS	NNP
cord-290677-3gdcyrrz	190	9	-	-	HYPH
cord-290677-3gdcyrrz	190	10	CoV-2	CoV-2	NNP
cord-290677-3gdcyrrz	190	11	cell	cell	NN
cord-290677-3gdcyrrz	190	12	entry	entry	NN
cord-290677-3gdcyrrz	190	13	depends	depend	VBZ
cord-290677-3gdcyrrz	190	14	on	on	IN
cord-290677-3gdcyrrz	190	15	ACE2	ACE2	NNP
cord-290677-3gdcyrrz	190	16	and	and	CC
cord-290677-3gdcyrrz	190	17	TMPRSS2	TMPRSS2	NNP
cord-290677-3gdcyrrz	190	18	and	and	CC
cord-290677-3gdcyrrz	190	19	is	be	VBZ
cord-290677-3gdcyrrz	190	20	blocked	block	VBN
cord-290677-3gdcyrrz	190	21	by	by	IN
cord-290677-3gdcyrrz	190	22	a	a	DT
cord-290677-3gdcyrrz	190	23	clinically	clinically	RB
cord-290677-3gdcyrrz	190	24	proven	prove	VBN
cord-290677-3gdcyrrz	190	25	protease	protease	NN
cord-290677-3gdcyrrz	190	26	inhibitor	inhibitor	NN
cord-290677-3gdcyrrz	190	27	The	the	DT
cord-290677-3gdcyrrz	190	28	ACE2	ACE2	NNP
cord-290677-3gdcyrrz	190	29	expression	expression	NN
cord-290677-3gdcyrrz	190	30	in	in	IN
cord-290677-3gdcyrrz	190	31	human	human	JJ
cord-290677-3gdcyrrz	190	32	heart	heart	NN
cord-290677-3gdcyrrz	190	33	indicates	indicate	VBZ
cord-290677-3gdcyrrz	190	34	new	new	JJ
cord-290677-3gdcyrrz	190	35	potential	potential	JJ
cord-290677-3gdcyrrz	190	36	mechanism	mechanism	NN
cord-290677-3gdcyrrz	190	37	of	of	IN
cord-290677-3gdcyrrz	190	38	heart	heart	NN
cord-290677-3gdcyrrz	190	39	injury	injury	NN
cord-290677-3gdcyrrz	190	40	among	among	IN
cord-290677-3gdcyrrz	190	41	patients	patient	NNS
cord-290677-3gdcyrrz	190	42	infected	infect	VBN
cord-290677-3gdcyrrz	190	43	with	with	IN
cord-290677-3gdcyrrz	190	44	SARS	SARS	NNP
cord-290677-3gdcyrrz	190	45	-	-	HYPH
cord-290677-3gdcyrrz	190	46	CoV-2	CoV-2	NNP
cord-290677-3gdcyrrz	190	47	Hierarchical	hierarchical	JJ
cord-290677-3gdcyrrz	190	48	deconstruction	deconstruction	NN
cord-290677-3gdcyrrz	190	49	of	of	IN
cord-290677-3gdcyrrz	190	50	mouse	mouse	NN
cord-290677-3gdcyrrz	190	51	olfactory	olfactory	JJ
cord-290677-3gdcyrrz	190	52	sensory	sensory	JJ
cord-290677-3gdcyrrz	190	53	neurons	neuron	NNS
cord-290677-3gdcyrrz	190	54	:	:	:
cord-290677-3gdcyrrz	190	55	from	from	IN
cord-290677-3gdcyrrz	190	56	whole	whole	JJ
cord-290677-3gdcyrrz	190	57	mucosa	mucosa	NN
cord-290677-3gdcyrrz	190	58	to	to	IN
cord-290677-3gdcyrrz	190	59	single	single	JJ
cord-290677-3gdcyrrz	190	60	-	-	HYPH
cord-290677-3gdcyrrz	190	61	cell	cell	NN
cord-290677-3gdcyrrz	190	62	RNA	RNA	NNP
cord-290677-3gdcyrrz	190	63	-	-	HYPH
cord-290677-3gdcyrrz	190	64	seq	seq	NNP
cord-290677-3gdcyrrz	190	65	Novel	Novel	NNP
cord-290677-3gdcyrrz	190	66	coronavirus	coronavirus	NN
cord-290677-3gdcyrrz	190	67	disease	disease	NN
cord-290677-3gdcyrrz	190	68	(	(	-LRB-
cord-290677-3gdcyrrz	190	69	COVID-19	COVID-19	NNP
cord-290677-3gdcyrrz	190	70	)	)	-RRB-
cord-290677-3gdcyrrz	190	71	and	and	CC
cord-290677-3gdcyrrz	190	72	central	central	JJ
cord-290677-3gdcyrrz	190	73	nervous	nervous	JJ
cord-290677-3gdcyrrz	190	74	system	system	NN
cord-290677-3gdcyrrz	190	75	complications	complication	NNS
cord-290677-3gdcyrrz	190	76	:	:	:
cord-290677-3gdcyrrz	190	77	what	what	WP
cord-290677-3gdcyrrz	190	78	neurologist	neurologist	NN
cord-290677-3gdcyrrz	190	79	need	need	VBP
cord-290677-3gdcyrrz	190	80	to	to	TO
cord-290677-3gdcyrrz	190	81	know	know	VB
cord-290677-3gdcyrrz	190	82	Brain	Brain	NNP
cord-290677-3gdcyrrz	190	83	angiotensin	angiotensin	NN
cord-290677-3gdcyrrz	190	84	-	-	HYPH
cord-290677-3gdcyrrz	190	85	converting	convert	VBG
cord-290677-3gdcyrrz	190	86	enzymes	enzyme	NNS
cord-290677-3gdcyrrz	190	87	:	:	:
cord-290677-3gdcyrrz	190	88	role	role	NN
cord-290677-3gdcyrrz	190	89	of	of	IN
cord-290677-3gdcyrrz	190	90	angiotensin	angiotensin	NN
cord-290677-3gdcyrrz	190	91	-	-	HYPH
cord-290677-3gdcyrrz	190	92	converting	convert	VBG
cord-290677-3gdcyrrz	190	93	enzyme	enzyme	NN
cord-290677-3gdcyrrz	190	94	2	2	CD
cord-290677-3gdcyrrz	190	95	in	in	IN
cord-290677-3gdcyrrz	190	96	processing	process	VBG
cord-290677-3gdcyrrz	190	97	angiotensin	angiotensin	NN
cord-290677-3gdcyrrz	190	98	II	II	NNP
cord-290677-3gdcyrrz	190	99	in	in	IN
cord-290677-3gdcyrrz	190	100	mice	mouse	NNS
cord-290677-3gdcyrrz	190	101	Anti	anti	JJ
cord-290677-3gdcyrrz	190	102	-	-	JJ
cord-290677-3gdcyrrz	190	103	hypersensitive	hypersensitive	JJ
cord-290677-3gdcyrrz	190	104	effect	effect	NN
cord-290677-3gdcyrrz	190	105	of	of	IN
cord-290677-3gdcyrrz	190	106	angiotensin	angiotensin	NN
cord-290677-3gdcyrrz	190	107	(	(	-LRB-
cord-290677-3gdcyrrz	190	108	1	1	CD
cord-290677-3gdcyrrz	190	109	-	-	SYM
cord-290677-3gdcyrrz	190	110	7	7	CD
cord-290677-3gdcyrrz	190	111	)	)	-RRB-
cord-290677-3gdcyrrz	190	112	on	on	IN
cord-290677-3gdcyrrz	190	113	streptozotocin	streptozotocin	NNS
cord-290677-3gdcyrrz	190	114	-	-	HYPH
cord-290677-3gdcyrrz	190	115	induced	induce	VBN
cord-290677-3gdcyrrz	190	116	diabetic	diabetic	JJ
cord-290677-3gdcyrrz	190	117	neuropathic	neuropathic	JJ
cord-290677-3gdcyrrz	190	118	pain	pain	NN
cord-290677-3gdcyrrz	190	119	in	in	IN
cord-290677-3gdcyrrz	190	120	mice	mouse	NNS
cord-290677-3gdcyrrz	191	1	Angiotensin	angiotensin	NN
cord-290677-3gdcyrrz	191	2	-	-	HYPH
cord-290677-3gdcyrrz	191	3	converting	convert	VBG
cord-290677-3gdcyrrz	191	4	enzyme	enzyme	NN
cord-290677-3gdcyrrz	191	5	2	2	CD
cord-290677-3gdcyrrz	191	6	in	in	IN
cord-290677-3gdcyrrz	191	7	the	the	DT
cord-290677-3gdcyrrz	191	8	rostral	rostral	JJ
cord-290677-3gdcyrrz	191	9	ventrolateral	ventrolateral	JJ
cord-290677-3gdcyrrz	191	10	medulla	medulla	NNP
cord-290677-3gdcyrrz	191	11	regulates	regulate	VBZ
cord-290677-3gdcyrrz	191	12	cholinergic	cholinergic	JJ
cord-290677-3gdcyrrz	191	13	signaling	signaling	NN
cord-290677-3gdcyrrz	191	14	and	and	CC
cord-290677-3gdcyrrz	191	15	cardiovascular	cardiovascular	JJ
cord-290677-3gdcyrrz	191	16	and	and	CC
cord-290677-3gdcyrrz	191	17	sympathetic	sympathetic	JJ
cord-290677-3gdcyrrz	191	18	responses	response	NNS
cord-290677-3gdcyrrz	191	19	in	in	IN
cord-290677-3gdcyrrz	191	20	hypertensive	hypertensive	JJ
cord-290677-3gdcyrrz	191	21	rats	rat	NNS
cord-290677-3gdcyrrz	192	1	Angiotensin	angiotensin	NN
cord-290677-3gdcyrrz	192	2	-	-	HYPH
cord-290677-3gdcyrrz	192	3	converting	convert	VBG
cord-290677-3gdcyrrz	192	4	enzyme	enzyme	NN
cord-290677-3gdcyrrz	192	5	2	2	CD
cord-290677-3gdcyrrz	192	6	:	:	:
cord-290677-3gdcyrrz	192	7	central	central	JJ
cord-290677-3gdcyrrz	192	8	regulator	regulator	NN
cord-290677-3gdcyrrz	192	9	for	for	IN
cord-290677-3gdcyrrz	192	10	cardiovascular	cardiovascular	JJ
cord-290677-3gdcyrrz	192	11	function	function	NN
cord-290677-3gdcyrrz	193	1	Avian	avian	JJ
cord-290677-3gdcyrrz	193	2	flu	flu	NN
cord-290677-3gdcyrrz	193	3	:	:	:
cord-290677-3gdcyrrz	194	1	influenza	influenza	NN
cord-290677-3gdcyrrz	194	2	virus	virus	NN
cord-290677-3gdcyrrz	194	3	receptors	receptor	NNS
cord-290677-3gdcyrrz	194	4	in	in	IN
cord-290677-3gdcyrrz	194	5	the	the	DT
cord-290677-3gdcyrrz	194	6	human	human	JJ
cord-290677-3gdcyrrz	194	7	airway	airway	NN
cord-290677-3gdcyrrz	194	8	H5N1	H5N1	NNP
cord-290677-3gdcyrrz	194	9	virus	virus	NN
cord-290677-3gdcyrrz	194	10	attachment	attachment	NN
cord-290677-3gdcyrrz	194	11	to	to	TO
cord-290677-3gdcyrrz	194	12	lower	lower	VB
cord-290677-3gdcyrrz	194	13	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	194	14	tract	tract	NN
cord-290677-3gdcyrrz	194	15	A	a	DT
cord-290677-3gdcyrrz	194	16	critical	critical	JJ
cord-290677-3gdcyrrz	194	17	function	function	NN
cord-290677-3gdcyrrz	194	18	for	for	IN
cord-290677-3gdcyrrz	194	19	CD200	cd200	NN
cord-290677-3gdcyrrz	194	20	in	in	IN
cord-290677-3gdcyrrz	194	21	lung	lung	NN
cord-290677-3gdcyrrz	194	22	immune	immune	JJ
cord-290677-3gdcyrrz	194	23	homeostasis	homeostasis	NN
cord-290677-3gdcyrrz	194	24	and	and	CC
cord-290677-3gdcyrrz	194	25	the	the	DT
cord-290677-3gdcyrrz	194	26	severity	severity	NN
cord-290677-3gdcyrrz	194	27	of	of	IN
cord-290677-3gdcyrrz	194	28	influenza	influenza	NN
cord-290677-3gdcyrrz	194	29	infection	infection	NN
cord-290677-3gdcyrrz	194	30	Identification	identification	NN
cord-290677-3gdcyrrz	194	31	of	of	IN
cord-290677-3gdcyrrz	194	32	a	a	DT
cord-290677-3gdcyrrz	194	33	nerve	nerve	NN
cord-290677-3gdcyrrz	194	34	-	-	HYPH
cord-290677-3gdcyrrz	194	35	associated	associate	VBN
cord-290677-3gdcyrrz	194	36	,	,	,
cord-290677-3gdcyrrz	194	37	lung	lung	NN
cord-290677-3gdcyrrz	194	38	-	-	HYPH
cord-290677-3gdcyrrz	194	39	resident	resident	JJ
cord-290677-3gdcyrrz	194	40	interstitial	interstitial	JJ
cord-290677-3gdcyrrz	194	41	macrophage	macrophage	NN
cord-290677-3gdcyrrz	194	42	subset	subset	VBN
cord-290677-3gdcyrrz	194	43	with	with	IN
cord-290677-3gdcyrrz	194	44	distinct	distinct	JJ
cord-290677-3gdcyrrz	194	45	localization	localization	NN
cord-290677-3gdcyrrz	194	46	and	and	CC
cord-290677-3gdcyrrz	194	47	immunoregulatory	immunoregulatory	JJ
cord-290677-3gdcyrrz	194	48	properties	property	NNS
cord-290677-3gdcyrrz	194	49	Regulating	regulate	VBG
cord-290677-3gdcyrrz	194	50	the	the	DT
cord-290677-3gdcyrrz	194	51	adaptive	adaptive	JJ
cord-290677-3gdcyrrz	194	52	immune	immune	JJ
cord-290677-3gdcyrrz	194	53	response	response	NN
cord-290677-3gdcyrrz	194	54	to	to	IN
cord-290677-3gdcyrrz	194	55	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	194	56	virus	virus	NN
cord-290677-3gdcyrrz	194	57	infection	infection	NN
cord-290677-3gdcyrrz	194	58	Respiratory	respiratory	JJ
cord-290677-3gdcyrrz	194	59	dendritic	dendritic	JJ
cord-290677-3gdcyrrz	194	60	cell	cell	NN
cord-290677-3gdcyrrz	194	61	subsets	subset	NNS
cord-290677-3gdcyrrz	194	62	differ	differ	VBP
cord-290677-3gdcyrrz	194	63	in	in	IN
cord-290677-3gdcyrrz	194	64	their	-PRON-	PRP$
cord-290677-3gdcyrrz	194	65	capacity	capacity	NN
cord-290677-3gdcyrrz	194	66	to	to	TO
cord-290677-3gdcyrrz	194	67	support	support	VB
cord-290677-3gdcyrrz	194	68	the	the	DT
cord-290677-3gdcyrrz	194	69	induction	induction	NN
cord-290677-3gdcyrrz	194	70	of	of	IN
cord-290677-3gdcyrrz	194	71	virus	virus	NN
cord-290677-3gdcyrrz	194	72	-	-	HYPH
cord-290677-3gdcyrrz	194	73	specific	specific	JJ
cord-290677-3gdcyrrz	194	74	cytotoxic	cytotoxic	JJ
cord-290677-3gdcyrrz	194	75	CD8	CD8	NNP
cord-290677-3gdcyrrz	194	76	+	+	CC
cord-290677-3gdcyrrz	194	77	T	T	NNP
cord-290677-3gdcyrrz	194	78	cell	cell	NN
cord-290677-3gdcyrrz	194	79	responses	response	NNS
cord-290677-3gdcyrrz	194	80	COVID-19	covid-19	CD
cord-290677-3gdcyrrz	194	81	infection	infection	NN
cord-290677-3gdcyrrz	194	82	:	:	:
cord-290677-3gdcyrrz	194	83	the	the	DT
cord-290677-3gdcyrrz	194	84	perspectives	perspective	NNS
cord-290677-3gdcyrrz	194	85	on	on	IN
cord-290677-3gdcyrrz	194	86	immune	immune	JJ
cord-290677-3gdcyrrz	194	87	responses	response	NNS
cord-290677-3gdcyrrz	194	88	Pathological	pathological	JJ
cord-290677-3gdcyrrz	194	89	findings	finding	NNS
cord-290677-3gdcyrrz	194	90	of	of	IN
cord-290677-3gdcyrrz	194	91	COVID-19	COVID-19	NNP
cord-290677-3gdcyrrz	194	92	associated	associate	VBN
cord-290677-3gdcyrrz	194	93	with	with	IN
cord-290677-3gdcyrrz	194	94	acute	acute	JJ
cord-290677-3gdcyrrz	194	95	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	194	96	distress	distress	NN
cord-290677-3gdcyrrz	194	97	syndrome	syndrome	NN
cord-290677-3gdcyrrz	194	98	Immune	immune	JJ
cord-290677-3gdcyrrz	194	99	cell	cell	NN
cord-290677-3gdcyrrz	194	100	profiling	profiling	NN
cord-290677-3gdcyrrz	194	101	of	of	IN
cord-290677-3gdcyrrz	194	102	COVID-19	covid-19	JJ
cord-290677-3gdcyrrz	194	103	patients	patient	NNS
cord-290677-3gdcyrrz	194	104	in	in	IN
cord-290677-3gdcyrrz	194	105	the	the	DT
cord-290677-3gdcyrrz	194	106	recovery	recovery	NN
cord-290677-3gdcyrrz	194	107	stage	stage	NN
cord-290677-3gdcyrrz	194	108	by	by	IN
cord-290677-3gdcyrrz	194	109	single	single	JJ
cord-290677-3gdcyrrz	194	110	-	-	HYPH
cord-290677-3gdcyrrz	194	111	cell	cell	NN
cord-290677-3gdcyrrz	194	112	sequencing	sequencing	NN
cord-290677-3gdcyrrz	194	113	COVID-19	COVID-19	NNP
cord-290677-3gdcyrrz	194	114	infection	infection	NN
cord-290677-3gdcyrrz	194	115	induces	induce	VBZ
cord-290677-3gdcyrrz	194	116	readily	readily	RB
cord-290677-3gdcyrrz	194	117	detectable	detectable	JJ
cord-290677-3gdcyrrz	194	118	morphological	morphological	JJ
cord-290677-3gdcyrrz	194	119	and	and	CC
cord-290677-3gdcyrrz	194	120	inflammation	inflammation	NN
cord-290677-3gdcyrrz	194	121	-	-	HYPH
cord-290677-3gdcyrrz	194	122	related	relate	VBN
cord-290677-3gdcyrrz	194	123	phenotypic	phenotypic	JJ
cord-290677-3gdcyrrz	194	124	changes	change	NNS
cord-290677-3gdcyrrz	194	125	in	in	IN
cord-290677-3gdcyrrz	194	126	peripheral	peripheral	JJ
cord-290677-3gdcyrrz	194	127	blood	blood	NN
cord-290677-3gdcyrrz	194	128	monocytes	monocyte	NNS
cord-290677-3gdcyrrz	194	129	,	,	,
cord-290677-3gdcyrrz	194	130	the	the	DT
cord-290677-3gdcyrrz	194	131	severity	severity	NN
cord-290677-3gdcyrrz	194	132	of	of	IN
cord-290677-3gdcyrrz	194	133	which	which	WDT
cord-290677-3gdcyrrz	194	134	correlate	correlate	VBP
cord-290677-3gdcyrrz	194	135	with	with	IN
cord-290677-3gdcyrrz	194	136	patient	patient	JJ
cord-290677-3gdcyrrz	194	137	outcome	outcome	NN
cord-290677-3gdcyrrz	195	1	A	a	DT
cord-290677-3gdcyrrz	195	2	new	new	JJ
cord-290677-3gdcyrrz	195	3	coronavirus	coronavirus	NN
cord-290677-3gdcyrrz	195	4	associated	associate	VBN
cord-290677-3gdcyrrz	195	5	with	with	IN
cord-290677-3gdcyrrz	195	6	human	human	JJ
cord-290677-3gdcyrrz	195	7	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	195	8	disease	disease	NN
cord-290677-3gdcyrrz	195	9	in	in	IN
cord-290677-3gdcyrrz	195	10	China	China	NNP
cord-290677-3gdcyrrz	195	11	Dysregulation	Dysregulation	NNP
cord-290677-3gdcyrrz	195	12	of	of	IN
cord-290677-3gdcyrrz	195	13	immune	immune	JJ
cord-290677-3gdcyrrz	195	14	response	response	NN
cord-290677-3gdcyrrz	195	15	in	in	IN
cord-290677-3gdcyrrz	195	16	patients	patient	NNS
cord-290677-3gdcyrrz	195	17	with	with	IN
cord-290677-3gdcyrrz	195	18	COVID-19	COVID-19	NNP
cord-290677-3gdcyrrz	195	19	in	in	IN
cord-290677-3gdcyrrz	195	20	Wuhan	Wuhan	NNP
cord-290677-3gdcyrrz	195	21	,	,	,
cord-290677-3gdcyrrz	195	22	China	China	NNP
cord-290677-3gdcyrrz	195	23	Clinical	clinical	JJ
cord-290677-3gdcyrrz	195	24	and	and	CC
cord-290677-3gdcyrrz	195	25	immunological	immunological	JJ
cord-290677-3gdcyrrz	195	26	features	feature	NNS
cord-290677-3gdcyrrz	195	27	of	of	IN
cord-290677-3gdcyrrz	195	28	severe	severe	JJ
cord-290677-3gdcyrrz	195	29	and	and	CC
cord-290677-3gdcyrrz	195	30	moderate	moderate	JJ
cord-290677-3gdcyrrz	195	31	coronavirus	coronavirus	NN
cord-290677-3gdcyrrz	195	32	disease	disease	NN
cord-290677-3gdcyrrz	195	33	2019	2019	CD
cord-290677-3gdcyrrz	195	34	Immunopathogenesis	Immunopathogenesis	NNP
cord-290677-3gdcyrrz	195	35	of	of	IN
cord-290677-3gdcyrrz	195	36	coronavirus	coronavirus	NN
cord-290677-3gdcyrrz	195	37	infections	infection	NNS
cord-290677-3gdcyrrz	195	38	:	:	:
cord-290677-3gdcyrrz	195	39	implications	implication	NNS
cord-290677-3gdcyrrz	195	40	for	for	IN
cord-290677-3gdcyrrz	195	41	SARS	SARS	NNP
cord-290677-3gdcyrrz	195	42	Middle	Middle	NNP
cord-290677-3gdcyrrz	195	43	East	East	NNP
cord-290677-3gdcyrrz	195	44	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	195	45	syndrome	syndrome	NN
cord-290677-3gdcyrrz	196	1	Clinical	clinical	JJ
cord-290677-3gdcyrrz	196	2	features	feature	NNS
cord-290677-3gdcyrrz	196	3	of	of	IN
cord-290677-3gdcyrrz	196	4	85	85	CD
cord-290677-3gdcyrrz	196	5	fatal	fatal	JJ
cord-290677-3gdcyrrz	196	6	cases	case	NNS
cord-290677-3gdcyrrz	196	7	of	of	IN
cord-290677-3gdcyrrz	196	8	COVID-19	COVID-19	NNP
cord-290677-3gdcyrrz	196	9	from	from	IN
cord-290677-3gdcyrrz	196	10	Wuhan	Wuhan	NNP
cord-290677-3gdcyrrz	196	11	.	.	.
cord-290677-3gdcyrrz	197	1	A	a	DT
cord-290677-3gdcyrrz	197	2	retrospective	retrospective	JJ
cord-290677-3gdcyrrz	197	3	observational	observational	JJ
cord-290677-3gdcyrrz	197	4	study	study	NN
cord-290677-3gdcyrrz	197	5	Hematologic	Hematologic	NNP
cord-290677-3gdcyrrz	197	6	,	,	,
cord-290677-3gdcyrrz	197	7	biochemical	biochemical	JJ
cord-290677-3gdcyrrz	197	8	and	and	CC
cord-290677-3gdcyrrz	197	9	immune	immune	JJ
cord-290677-3gdcyrrz	197	10	biomarker	biomarker	NN
cord-290677-3gdcyrrz	197	11	abnormalities	abnormality	NNS
cord-290677-3gdcyrrz	197	12	associated	associate	VBN
cord-290677-3gdcyrrz	197	13	with	with	IN
cord-290677-3gdcyrrz	197	14	severe	severe	JJ
cord-290677-3gdcyrrz	197	15	illness	illness	NN
cord-290677-3gdcyrrz	197	16	and	and	CC
cord-290677-3gdcyrrz	197	17	mortality	mortality	NN
cord-290677-3gdcyrrz	197	18	in	in	IN
cord-290677-3gdcyrrz	197	19	coronavirus	coronavirus	NN
cord-290677-3gdcyrrz	197	20	disease	disease	NN
cord-290677-3gdcyrrz	197	21	2019	2019	CD
cord-290677-3gdcyrrz	197	22	(	(	-LRB-
cord-290677-3gdcyrrz	197	23	COVID-19	COVID-19	NNP
cord-290677-3gdcyrrz	197	24	)	)	-RRB-
cord-290677-3gdcyrrz	197	25	:	:	:
cord-290677-3gdcyrrz	197	26	a	a	DT
cord-290677-3gdcyrrz	197	27	meta	meta	JJ
cord-290677-3gdcyrrz	197	28	-	-	HYPH
cord-290677-3gdcyrrz	197	29	analysis	analysis	NN
cord-290677-3gdcyrrz	197	30	IL-6	IL-6	NNP
cord-290677-3gdcyrrz	197	31	signalling	signal	VBG
cord-290677-3gdcyrrz	197	32	pathway	pathway	NN
cord-290677-3gdcyrrz	197	33	inactivation	inactivation	NN
cord-290677-3gdcyrrz	197	34	with	with	IN
cord-290677-3gdcyrrz	197	35	siltuximab	siltuximab	NNS
cord-290677-3gdcyrrz	197	36	in	in	IN
cord-290677-3gdcyrrz	197	37	patients	patient	NNS
cord-290677-3gdcyrrz	197	38	with	with	IN
cord-290677-3gdcyrrz	197	39	COVID-19	covid-19	JJ
cord-290677-3gdcyrrz	197	40	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	197	41	failure	failure	NN
cord-290677-3gdcyrrz	197	42	:	:	:
cord-290677-3gdcyrrz	198	1	an	an	DT
cord-290677-3gdcyrrz	198	2	observational	observational	JJ
cord-290677-3gdcyrrz	198	3	cohort	cohort	NN
cord-290677-3gdcyrrz	198	4	study	study	NN
cord-290677-3gdcyrrz	198	5	Is	be	VBZ
cord-290677-3gdcyrrz	198	6	a	a	DT
cord-290677-3gdcyrrz	198	7	"	"	``
cord-290677-3gdcyrrz	198	8	cytokine	cytokine	NN
cord-290677-3gdcyrrz	198	9	storm	storm	NN
cord-290677-3gdcyrrz	198	10	"	"	''
cord-290677-3gdcyrrz	198	11	relevant	relevant	JJ
cord-290677-3gdcyrrz	198	12	to	to	IN
cord-290677-3gdcyrrz	198	13	COVID-19	covid-19	VB
cord-290677-3gdcyrrz	198	14	?	?	.
cord-290677-3gdcyrrz	199	1	Ageing	age	VBG
cord-290677-3gdcyrrz	199	2	and	and	CC
cord-290677-3gdcyrrz	199	3	the	the	DT
cord-290677-3gdcyrrz	199	4	immune	immune	JJ
cord-290677-3gdcyrrz	199	5	system	system	NN
cord-290677-3gdcyrrz	199	6	:	:	:
cord-290677-3gdcyrrz	199	7	focus	focus	VB
cord-290677-3gdcyrrz	199	8	on	on	IN
cord-290677-3gdcyrrz	199	9	macrophages	macrophage	NNS
cord-290677-3gdcyrrz	200	1	Age	age	NN
cord-290677-3gdcyrrz	200	2	related	relate	VBD
cord-290677-3gdcyrrz	200	3	human	human	JJ
cord-290677-3gdcyrrz	200	4	T	t	NN
cord-290677-3gdcyrrz	200	5	cell	cell	NN
cord-290677-3gdcyrrz	200	6	subset	subset	VBN
cord-290677-3gdcyrrz	200	7	evolution	evolution	NN
cord-290677-3gdcyrrz	200	8	and	and	CC
cord-290677-3gdcyrrz	200	9	senescence	senescence	NN
cord-290677-3gdcyrrz	200	10	Age	Age	NNP
cord-290677-3gdcyrrz	200	11	is	be	VBZ
cord-290677-3gdcyrrz	200	12	not	not	RB
cord-290677-3gdcyrrz	200	13	just	just	RB
cord-290677-3gdcyrrz	200	14	a	a	DT
cord-290677-3gdcyrrz	200	15	number	number	NN
cord-290677-3gdcyrrz	200	16	:	:	:
cord-290677-3gdcyrrz	200	17	naive	naive	JJ
cord-290677-3gdcyrrz	200	18	T	t	NN
cord-290677-3gdcyrrz	200	19	cells	cell	NNS
cord-290677-3gdcyrrz	200	20	increase	increase	VBP
cord-290677-3gdcyrrz	200	21	their	-PRON-	PRP$
cord-290677-3gdcyrrz	200	22	ability	ability	NN
cord-290677-3gdcyrrz	200	23	to	to	TO
cord-290677-3gdcyrrz	200	24	persist	persist	VB
cord-290677-3gdcyrrz	200	25	in	in	IN
cord-290677-3gdcyrrz	200	26	the	the	DT
cord-290677-3gdcyrrz	200	27	circulation	circulation	NN
cord-290677-3gdcyrrz	200	28	over	over	IN
cord-290677-3gdcyrrz	200	29	time	time	NN
cord-290677-3gdcyrrz	201	1	Innervation	innervation	NN
cord-290677-3gdcyrrz	201	2	of	of	IN
cord-290677-3gdcyrrz	201	3	the	the	DT
cord-290677-3gdcyrrz	201	4	guinea	guinea	NN
cord-290677-3gdcyrrz	201	5	pig	pig	NN
cord-290677-3gdcyrrz	201	6	trachea	trachea	NNP
cord-290677-3gdcyrrz	201	7	:	:	:
cord-290677-3gdcyrrz	201	8	a	a	DT
cord-290677-3gdcyrrz	201	9	quantitative	quantitative	JJ
cord-290677-3gdcyrrz	201	10	morphological	morphological	JJ
cord-290677-3gdcyrrz	201	11	study	study	NN
cord-290677-3gdcyrrz	201	12	of	of	IN
cord-290677-3gdcyrrz	201	13	intrinsic	intrinsic	JJ
cord-290677-3gdcyrrz	201	14	neurons	neuron	NNS
cord-290677-3gdcyrrz	201	15	and	and	CC
cord-290677-3gdcyrrz	201	16	extrinsic	extrinsic	JJ
cord-290677-3gdcyrrz	201	17	nerves	nerve	NNS
cord-290677-3gdcyrrz	202	1	The	the	DT
cord-290677-3gdcyrrz	202	2	sensory	sensory	JJ
cord-290677-3gdcyrrz	202	3	and	and	CC
cord-290677-3gdcyrrz	202	4	sympathetic	sympathetic	JJ
cord-290677-3gdcyrrz	202	5	innervation	innervation	NN
cord-290677-3gdcyrrz	202	6	of	of	IN
cord-290677-3gdcyrrz	202	7	guinea	guinea	NN
cord-290677-3gdcyrrz	202	8	-	-	HYPH
cord-290677-3gdcyrrz	202	9	pig	pig	NN
cord-290677-3gdcyrrz	202	10	lung	lung	NN
cord-290677-3gdcyrrz	202	11	and	and	CC
cord-290677-3gdcyrrz	202	12	trachea	trachea	NN
cord-290677-3gdcyrrz	202	13	as	as	IN
cord-290677-3gdcyrrz	202	14	studied	study	VBN
cord-290677-3gdcyrrz	202	15	by	by	IN
cord-290677-3gdcyrrz	202	16	retrograde	retrograde	JJ
cord-290677-3gdcyrrz	202	17	neuronal	neuronal	JJ
cord-290677-3gdcyrrz	202	18	tracing	tracing	NN
cord-290677-3gdcyrrz	202	19	and	and	CC
cord-290677-3gdcyrrz	202	20	double	double	JJ
cord-290677-3gdcyrrz	202	21	-	-	HYPH
cord-290677-3gdcyrrz	202	22	labelling	labelling	NN
cord-290677-3gdcyrrz	202	23	immunohistochemistry	immunohistochemistry	NN
cord-290677-3gdcyrrz	202	24	Chronic	chronic	JJ
cord-290677-3gdcyrrz	202	25	obstructive	obstructive	JJ
cord-290677-3gdcyrrz	202	26	pulmonary	pulmonary	JJ
cord-290677-3gdcyrrz	202	27	disease	disease	NN
cord-290677-3gdcyrrz	202	28	Overview	Overview	NNP
cord-290677-3gdcyrrz	202	29	of	of	IN
cord-290677-3gdcyrrz	202	30	neural	neural	JJ
cord-290677-3gdcyrrz	202	31	mechanisms	mechanism	NNS
cord-290677-3gdcyrrz	202	32	in	in	IN
cord-290677-3gdcyrrz	202	33	asthma	asthma	NN
cord-290677-3gdcyrrz	202	34	Evidence	evidence	NN
cord-290677-3gdcyrrz	202	35	for	for	IN
cord-290677-3gdcyrrz	202	36	prejunctional	prejunctional	JJ
cord-290677-3gdcyrrz	202	37	muscarinic	muscarinic	JJ
cord-290677-3gdcyrrz	202	38	autoreceptors	autoreceptor	NNS
cord-290677-3gdcyrrz	202	39	in	in	IN
cord-290677-3gdcyrrz	202	40	human	human	JJ
cord-290677-3gdcyrrz	202	41	and	and	CC
cord-290677-3gdcyrrz	202	42	guinea	guinea	NN
cord-290677-3gdcyrrz	202	43	pig	pig	NN
cord-290677-3gdcyrrz	202	44	trachea	trachea	NN
cord-290677-3gdcyrrz	202	45	Parainfluenza	Parainfluenza	NNP
cord-290677-3gdcyrrz	202	46	virus	virus	NN
cord-290677-3gdcyrrz	202	47	infection	infection	NN
cord-290677-3gdcyrrz	202	48	damages	damage	VBZ
cord-290677-3gdcyrrz	202	49	inhibitory	inhibitory	JJ
cord-290677-3gdcyrrz	202	50	M2	m2	JJ
cord-290677-3gdcyrrz	202	51	muscarinic	muscarinic	JJ
cord-290677-3gdcyrrz	202	52	receptors	receptor	NNS
cord-290677-3gdcyrrz	202	53	on	on	IN
cord-290677-3gdcyrrz	202	54	pulmonary	pulmonary	JJ
cord-290677-3gdcyrrz	202	55	parasympathetic	parasympathetic	JJ
cord-290677-3gdcyrrz	202	56	nerves	nerve	NNS
cord-290677-3gdcyrrz	202	57	in	in	IN
cord-290677-3gdcyrrz	202	58	the	the	DT
cord-290677-3gdcyrrz	202	59	guinea	guinea	NN
cord-290677-3gdcyrrz	202	60	-	-	HYPH
cord-290677-3gdcyrrz	202	61	pig	pig	NN
cord-290677-3gdcyrrz	202	62	Dysfunction	Dysfunction	NNP
cord-290677-3gdcyrrz	202	63	of	of	IN
cord-290677-3gdcyrrz	202	64	M2-muscarinic	m2-muscarinic	JJ
cord-290677-3gdcyrrz	202	65	receptors	receptor	NNS
cord-290677-3gdcyrrz	202	66	in	in	IN
cord-290677-3gdcyrrz	202	67	pulmonary	pulmonary	JJ
cord-290677-3gdcyrrz	202	68	parasympathetic	parasympathetic	JJ
cord-290677-3gdcyrrz	202	69	nerves	nerve	NNS
cord-290677-3gdcyrrz	202	70	after	after	IN
cord-290677-3gdcyrrz	202	71	antigen	antigen	NN
cord-290677-3gdcyrrz	202	72	challenge	challenge	NN
cord-290677-3gdcyrrz	202	73	Expression	expression	NN
cord-290677-3gdcyrrz	202	74	of	of	IN
cord-290677-3gdcyrrz	202	75	muscarinic	muscarinic	JJ
cord-290677-3gdcyrrz	202	76	receptors	receptor	NNS
cord-290677-3gdcyrrz	202	77	by	by	IN
cord-290677-3gdcyrrz	202	78	human	human	JJ
cord-290677-3gdcyrrz	202	79	macrophages	macrophage	NNS
cord-290677-3gdcyrrz	203	1	Interleukin-1β	Interleukin-1β	NNP
cord-290677-3gdcyrrz	203	2	mediates	mediate	VBZ
cord-290677-3gdcyrrz	203	3	virus	virus	NN
cord-290677-3gdcyrrz	203	4	-	-	HYPH
cord-290677-3gdcyrrz	203	5	induced	induce	VBN
cord-290677-3gdcyrrz	203	6	M2	M2	NNP
cord-290677-3gdcyrrz	203	7	muscarinic	muscarinic	JJ
cord-290677-3gdcyrrz	203	8	receptor	receptor	NN
cord-290677-3gdcyrrz	203	9	dysfunction	dysfunction	NN
cord-290677-3gdcyrrz	203	10	and	and	CC
cord-290677-3gdcyrrz	203	11	airway	airway	NNP
cord-290677-3gdcyrrz	203	12	hyperreactivity	hyperreactivity	NNP
cord-290677-3gdcyrrz	203	13	Virus	Virus	NNP
cord-290677-3gdcyrrz	203	14	-	-	:
cord-290677-3gdcyrrz	203	15	and	and	CC
cord-290677-3gdcyrrz	203	16	interferon	interferon	NN
cord-290677-3gdcyrrz	203	17	-	-	HYPH
cord-290677-3gdcyrrz	203	18	induced	induce	VBN
cord-290677-3gdcyrrz	203	19	loss	loss	NN
cord-290677-3gdcyrrz	203	20	of	of	IN
cord-290677-3gdcyrrz	203	21	inhibitory	inhibitory	JJ
cord-290677-3gdcyrrz	203	22	M2	m2	JJ
cord-290677-3gdcyrrz	203	23	muscarinic	muscarinic	JJ
cord-290677-3gdcyrrz	203	24	receptor	receptor	NN
cord-290677-3gdcyrrz	203	25	function	function	NN
cord-290677-3gdcyrrz	203	26	and	and	CC
cord-290677-3gdcyrrz	203	27	gene	gene	NN
cord-290677-3gdcyrrz	203	28	expression	expression	NN
cord-290677-3gdcyrrz	203	29	in	in	IN
cord-290677-3gdcyrrz	204	1	cultured	cultured	JJ
cord-290677-3gdcyrrz	204	2	airway	airway	NN
cord-290677-3gdcyrrz	204	3	parasympathetic	parasympathetic	JJ
cord-290677-3gdcyrrz	204	4	neurons	neuron	NNS
cord-290677-3gdcyrrz	204	5	IFNγ	IFNγ	NNS
cord-290677-3gdcyrrz	204	6	increases	increase	VBZ
cord-290677-3gdcyrrz	204	7	M2	M2	NNP
cord-290677-3gdcyrrz	204	8	muscarinic	muscarinic	JJ
cord-290677-3gdcyrrz	204	9	receptor	receptor	NN
cord-290677-3gdcyrrz	204	10	expression	expression	NN
cord-290677-3gdcyrrz	204	11	in	in	IN
cord-290677-3gdcyrrz	204	12	cultured	cultured	JJ
cord-290677-3gdcyrrz	204	13	sympathetic	sympathetic	JJ
cord-290677-3gdcyrrz	204	14	neurons	neuron	NNS
cord-290677-3gdcyrrz	204	15	Severe	severe	JJ
cord-290677-3gdcyrrz	204	16	acute	acute	JJ
cord-290677-3gdcyrrz	204	17	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	204	18	syndrome	syndrome	NN
cord-290677-3gdcyrrz	204	19	(	(	-LRB-
cord-290677-3gdcyrrz	205	1	SARS	SARS	NNP
cord-290677-3gdcyrrz	205	2	)	)	-RRB-
cord-290677-3gdcyrrz	205	3	coronavirus	coronavirus	NN
cord-290677-3gdcyrrz	205	4	-	-	HYPH
cord-290677-3gdcyrrz	205	5	induced	induce	VBN
cord-290677-3gdcyrrz	205	6	lung	lung	NN
cord-290677-3gdcyrrz	205	7	epithelial	epithelial	JJ
cord-290677-3gdcyrrz	205	8	cytokines	cytokine	NNS
cord-290677-3gdcyrrz	205	9	exacerbate	exacerbate	VBP
cord-290677-3gdcyrrz	205	10	SARS	SARS	NNP
cord-290677-3gdcyrrz	205	11	pathogenesis	pathogenesis	NN
cord-290677-3gdcyrrz	205	12	by	by	IN
cord-290677-3gdcyrrz	205	13	modulating	modulate	VBG
cord-290677-3gdcyrrz	205	14	intrinsic	intrinsic	JJ
cord-290677-3gdcyrrz	205	15	functions	function	NNS
cord-290677-3gdcyrrz	205	16	of	of	IN
cord-290677-3gdcyrrz	205	17	monocyte	monocyte	NNP
cord-290677-3gdcyrrz	205	18	-	-	HYPH
cord-290677-3gdcyrrz	205	19	derived	derive	VBN
cord-290677-3gdcyrrz	205	20	macrophages	macrophage	NNS
cord-290677-3gdcyrrz	205	21	and	and	CC
cord-290677-3gdcyrrz	205	22	dendritic	dendritic	JJ
cord-290677-3gdcyrrz	205	23	cells	cell	NNS
cord-290677-3gdcyrrz	205	24	Induction	Induction	NNP
cord-290677-3gdcyrrz	205	25	of	of	IN
cord-290677-3gdcyrrz	205	26	pro	pro	JJ
cord-290677-3gdcyrrz	205	27	-	-	JJ
cord-290677-3gdcyrrz	205	28	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	205	29	cytokines	cytokine	NNS
cord-290677-3gdcyrrz	205	30	(	(	-LRB-
cord-290677-3gdcyrrz	205	31	IL-1	IL-1	NNP
cord-290677-3gdcyrrz	205	32	and	and	CC
cord-290677-3gdcyrrz	205	33	IL-6	IL-6	NNP
cord-290677-3gdcyrrz	205	34	)	)	-RRB-
cord-290677-3gdcyrrz	205	35	and	and	CC
cord-290677-3gdcyrrz	205	36	lung	lung	NN
cord-290677-3gdcyrrz	205	37	inflammation	inflammation	NN
cord-290677-3gdcyrrz	205	38	by	by	IN
cord-290677-3gdcyrrz	205	39	Coronavirus-19	Coronavirus-19	NNP
cord-290677-3gdcyrrz	205	40	(	(	-LRB-
cord-290677-3gdcyrrz	205	41	COVI-19	COVI-19	NNP
cord-290677-3gdcyrrz	205	42	or	or	CC
cord-290677-3gdcyrrz	205	43	SARS	SARS	NNP
cord-290677-3gdcyrrz	205	44	-	-	HYPH
cord-290677-3gdcyrrz	205	45	CoV-2	CoV-2	NNP
cord-290677-3gdcyrrz	205	46	)	)	-RRB-
cord-290677-3gdcyrrz	205	47	:	:	:
cord-290677-3gdcyrrz	205	48	anti	anti	JJ
cord-290677-3gdcyrrz	205	49	-	-	JJ
cord-290677-3gdcyrrz	205	50	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	205	51	strategies	strategy	NNS
cord-290677-3gdcyrrz	205	52	Mechanisms	Mechanisms	NNPS
cord-290677-3gdcyrrz	205	53	of	of	IN
cord-290677-3gdcyrrz	205	54	bronchial	bronchial	JJ
cord-290677-3gdcyrrz	205	55	hyperreactivity	hyperreactivity	NN
cord-290677-3gdcyrrz	205	56	in	in	IN
cord-290677-3gdcyrrz	205	57	normal	normal	JJ
cord-290677-3gdcyrrz	205	58	subjects	subject	NNS
cord-290677-3gdcyrrz	205	59	after	after	IN
cord-290677-3gdcyrrz	205	60	upper	upper	JJ
cord-290677-3gdcyrrz	205	61	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	205	62	tract	tract	NN
cord-290677-3gdcyrrz	205	63	infection	infection	NN
cord-290677-3gdcyrrz	206	1	An	an	DT
cord-290677-3gdcyrrz	206	2	airway	airway	NN
cord-290677-3gdcyrrz	206	3	protection	protection	NN
cord-290677-3gdcyrrz	206	4	program	program	NN
cord-290677-3gdcyrrz	206	5	revealed	reveal	VBN
cord-290677-3gdcyrrz	206	6	by	by	IN
cord-290677-3gdcyrrz	206	7	sweeping	sweeping	JJ
cord-290677-3gdcyrrz	206	8	genetic	genetic	JJ
cord-290677-3gdcyrrz	206	9	control	control	NN
cord-290677-3gdcyrrz	206	10	of	of	IN
cord-290677-3gdcyrrz	206	11	vagal	vagal	JJ
cord-290677-3gdcyrrz	206	12	afferents	afferent	NNS
cord-290677-3gdcyrrz	206	13	Piezo2	Piezo2	NNP
cord-290677-3gdcyrrz	206	14	senses	sense	VBZ
cord-290677-3gdcyrrz	206	15	airway	airway	NN
cord-290677-3gdcyrrz	206	16	stretch	stretch	NN
cord-290677-3gdcyrrz	206	17	and	and	CC
cord-290677-3gdcyrrz	206	18	mediates	mediate	VBZ
cord-290677-3gdcyrrz	206	19	lung	lung	NN
cord-290677-3gdcyrrz	206	20	inflation	inflation	NN
cord-290677-3gdcyrrz	206	21	-	-	HYPH
cord-290677-3gdcyrrz	206	22	induced	induce	VBN
cord-290677-3gdcyrrz	206	23	apnoea	apnoea	NN
cord-290677-3gdcyrrz	206	24	Mechanisms	Mechanisms	NNPS
cord-290677-3gdcyrrz	206	25	in	in	IN
cord-290677-3gdcyrrz	206	26	COPD	COPD	NNP
cord-290677-3gdcyrrz	206	27	:	:	:
cord-290677-3gdcyrrz	206	28	differences	difference	NNS
cord-290677-3gdcyrrz	206	29	from	from	IN
cord-290677-3gdcyrrz	206	30	asthma	asthma	NN
cord-290677-3gdcyrrz	206	31	Pulmonary	pulmonary	JJ
cord-290677-3gdcyrrz	206	32	neuroendocrine	neuroendocrine	JJ
cord-290677-3gdcyrrz	206	33	cell	cell	NN
cord-290677-3gdcyrrz	206	34	system	system	NN
cord-290677-3gdcyrrz	206	35	in	in	IN
cord-290677-3gdcyrrz	206	36	health	health	NN
cord-290677-3gdcyrrz	206	37	and	and	CC
cord-290677-3gdcyrrz	206	38	disease	disease	NN
cord-290677-3gdcyrrz	206	39	Functional	functional	JJ
cord-290677-3gdcyrrz	206	40	morphology	morphology	NN
cord-290677-3gdcyrrz	206	41	of	of	IN
cord-290677-3gdcyrrz	206	42	pulmonary	pulmonary	JJ
cord-290677-3gdcyrrz	206	43	neuroepithelial	neuroepithelial	JJ
cord-290677-3gdcyrrz	206	44	bodies	body	NNS
cord-290677-3gdcyrrz	206	45	:	:	:
cord-290677-3gdcyrrz	206	46	extremely	extremely	RB
cord-290677-3gdcyrrz	206	47	complex	complex	JJ
cord-290677-3gdcyrrz	206	48	airway	airway	NN
cord-290677-3gdcyrrz	206	49	receptors	receptor	NNS
cord-290677-3gdcyrrz	206	50	Pulmonary	pulmonary	JJ
cord-290677-3gdcyrrz	206	51	neuroendocrine	neuroendocrine	JJ
cord-290677-3gdcyrrz	206	52	cells	cell	NNS
cord-290677-3gdcyrrz	206	53	.	.	.
cord-290677-3gdcyrrz	207	1	Their	-PRON-	PRP$
cord-290677-3gdcyrrz	207	2	secretory	secretory	JJ
cord-290677-3gdcyrrz	207	3	products	product	NNS
cord-290677-3gdcyrrz	207	4	and	and	CC
cord-290677-3gdcyrrz	207	5	their	-PRON-	PRP$
cord-290677-3gdcyrrz	207	6	potential	potential	JJ
cord-290677-3gdcyrrz	207	7	roles	role	NNS
cord-290677-3gdcyrrz	207	8	in	in	IN
cord-290677-3gdcyrrz	207	9	health	health	NN
cord-290677-3gdcyrrz	207	10	and	and	CC
cord-290677-3gdcyrrz	207	11	chronic	chronic	JJ
cord-290677-3gdcyrrz	207	12	lung	lung	NN
cord-290677-3gdcyrrz	207	13	disease	disease	NN
cord-290677-3gdcyrrz	207	14	in	in	IN
cord-290677-3gdcyrrz	207	15	infancy	infancy	JJ
cord-290677-3gdcyrrz	207	16	Functional	functional	JJ
cord-290677-3gdcyrrz	207	17	facets	facet	NNS
cord-290677-3gdcyrrz	207	18	of	of	IN
cord-290677-3gdcyrrz	207	19	the	the	DT
cord-290677-3gdcyrrz	207	20	pulmonary	pulmonary	JJ
cord-290677-3gdcyrrz	207	21	neuroendocrine	neuroendocrine	JJ
cord-290677-3gdcyrrz	207	22	system	system	NN
cord-290677-3gdcyrrz	208	1	The	the	DT
cord-290677-3gdcyrrz	208	2	role	role	NN
cord-290677-3gdcyrrz	208	3	of	of	IN
cord-290677-3gdcyrrz	208	4	virus	virus	NN
cord-290677-3gdcyrrz	208	5	-	-	HYPH
cord-290677-3gdcyrrz	208	6	specific	specific	JJ
cord-290677-3gdcyrrz	208	7	immunoglobulin	immunoglobulin	NN
cord-290677-3gdcyrrz	208	8	E	e	NN
cord-290677-3gdcyrrz	208	9	in	in	IN
cord-290677-3gdcyrrz	208	10	airway	airway	NNP
cord-290677-3gdcyrrz	208	11	hyperresponsiveness	hyperresponsiveness	NNP
cord-290677-3gdcyrrz	209	1	Calcitonin	calcitonin	JJ
cord-290677-3gdcyrrz	209	2	gene	gene	NN
cord-290677-3gdcyrrz	209	3	-	-	HYPH
cord-290677-3gdcyrrz	209	4	related	relate	VBN
cord-290677-3gdcyrrz	209	5	peptide	peptide	NN
cord-290677-3gdcyrrz	209	6	as	as	IN
cord-290677-3gdcyrrz	209	7	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	209	8	mediator	mediator	NN
cord-290677-3gdcyrrz	209	9	Bombesin	Bombesin	NNP
cord-290677-3gdcyrrz	209	10	-	-	HYPH
cord-290677-3gdcyrrz	209	11	related	relate	VBN
cord-290677-3gdcyrrz	209	12	peptides	peptide	NNS
cord-290677-3gdcyrrz	209	13	and	and	CC
cord-290677-3gdcyrrz	209	14	their	-PRON-	PRP$
cord-290677-3gdcyrrz	209	15	receptors	receptor	NNS
cord-290677-3gdcyrrz	209	16	:	:	:
cord-290677-3gdcyrrz	210	1	recent	recent	JJ
cord-290677-3gdcyrrz	210	2	advances	advance	NNS
cord-290677-3gdcyrrz	210	3	in	in	IN
cord-290677-3gdcyrrz	210	4	their	-PRON-	PRP$
cord-290677-3gdcyrrz	210	5	role	role	NN
cord-290677-3gdcyrrz	210	6	in	in	IN
cord-290677-3gdcyrrz	210	7	physiology	physiology	NN
cord-290677-3gdcyrrz	210	8	and	and	CC
cord-290677-3gdcyrrz	210	9	disease	disease	NN
cord-290677-3gdcyrrz	210	10	states	state	NNS
cord-290677-3gdcyrrz	210	11	Immunomodulatory	immunomodulatory	JJ
cord-290677-3gdcyrrz	210	12	functions	function	NNS
cord-290677-3gdcyrrz	210	13	of	of	IN
cord-290677-3gdcyrrz	210	14	the	the	DT
cord-290677-3gdcyrrz	210	15	diffuse	diffuse	JJ
cord-290677-3gdcyrrz	210	16	neuroendocrine	neuroendocrine	JJ
cord-290677-3gdcyrrz	210	17	system	system	NN
cord-290677-3gdcyrrz	210	18	:	:	:
cord-290677-3gdcyrrz	210	19	implications	implication	NNS
cord-290677-3gdcyrrz	210	20	for	for	IN
cord-290677-3gdcyrrz	210	21	bronchopulmonary	bronchopulmonary	JJ
cord-290677-3gdcyrrz	210	22	dysplasia	dysplasia	NN
cord-290677-3gdcyrrz	211	1	The	the	DT
cord-290677-3gdcyrrz	211	2	vagus	vagus	NN
cord-290677-3gdcyrrz	211	3	nerve	nerve	NN
cord-290677-3gdcyrrz	211	4	in	in	IN
cord-290677-3gdcyrrz	211	5	the	the	DT
cord-290677-3gdcyrrz	211	6	neuro	neuro	NNP
cord-290677-3gdcyrrz	211	7	-	-	HYPH
cord-290677-3gdcyrrz	211	8	immune	immune	JJ
cord-290677-3gdcyrrz	211	9	axis	axis	NN
cord-290677-3gdcyrrz	211	10	:	:	:
cord-290677-3gdcyrrz	211	11	implications	implication	NNS
cord-290677-3gdcyrrz	211	12	in	in	IN
cord-290677-3gdcyrrz	211	13	the	the	DT
cord-290677-3gdcyrrz	211	14	pathology	pathology	NN
cord-290677-3gdcyrrz	211	15	of	of	IN
cord-290677-3gdcyrrz	211	16	the	the	DT
cord-290677-3gdcyrrz	211	17	gastrointestinal	gastrointestinal	JJ
cord-290677-3gdcyrrz	211	18	tract	tract	NN
cord-290677-3gdcyrrz	211	19	Anti	anti	JJ
cord-290677-3gdcyrrz	211	20	-	-	JJ
cord-290677-3gdcyrrz	211	21	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	211	22	effects	effect	NNS
cord-290677-3gdcyrrz	211	23	of	of	IN
cord-290677-3gdcyrrz	211	24	abdominal	abdominal	JJ
cord-290677-3gdcyrrz	211	25	vagus	vagus	NN
cord-290677-3gdcyrrz	211	26	nerve	nerve	NN
cord-290677-3gdcyrrz	211	27	stimulation	stimulation	NN
cord-290677-3gdcyrrz	211	28	on	on	IN
cord-290677-3gdcyrrz	211	29	experimental	experimental	JJ
cord-290677-3gdcyrrz	211	30	intestinal	intestinal	JJ
cord-290677-3gdcyrrz	211	31	inflammation	inflammation	NN
cord-290677-3gdcyrrz	212	1	The	the	DT
cord-290677-3gdcyrrz	212	2	vagus	vagus	NN
cord-290677-3gdcyrrz	212	3	nerve	nerve	NN
cord-290677-3gdcyrrz	212	4	and	and	CC
cord-290677-3gdcyrrz	212	5	the	the	DT
cord-290677-3gdcyrrz	212	6	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	212	7	reflex	reflex	NN
cord-290677-3gdcyrrz	213	1	-linking	-linke	VBG
cord-290677-3gdcyrrz	213	2	immunity	immunity	NN
cord-290677-3gdcyrrz	213	3	and	and	CC
cord-290677-3gdcyrrz	213	4	metabolism	metabolism	NN
cord-290677-3gdcyrrz	213	5	Electric	electric	JJ
cord-290677-3gdcyrrz	213	6	stimulation	stimulation	NN
cord-290677-3gdcyrrz	213	7	of	of	IN
cord-290677-3gdcyrrz	213	8	the	the	DT
cord-290677-3gdcyrrz	213	9	vagus	vagus	NN
cord-290677-3gdcyrrz	213	10	nerve	nerve	NN
cord-290677-3gdcyrrz	213	11	reduced	reduce	VBN
cord-290677-3gdcyrrz	213	12	mouse	mouse	NN
cord-290677-3gdcyrrz	213	13	neuroinflammation	neuroinflammation	NN
cord-290677-3gdcyrrz	213	14	induced	induce	VBN
cord-290677-3gdcyrrz	213	15	by	by	IN
cord-290677-3gdcyrrz	213	16	lipopolysaccharide	lipopolysaccharide	NN
cord-290677-3gdcyrrz	213	17	α7	α7	NNP
cord-290677-3gdcyrrz	213	18	nicotinic	nicotinic	JJ
cord-290677-3gdcyrrz	213	19	acetylcholine	acetylcholine	NN
cord-290677-3gdcyrrz	213	20	receptor	receptor	NN
cord-290677-3gdcyrrz	213	21	(	(	-LRB-
cord-290677-3gdcyrrz	213	22	α7nAChR	α7nachr	CD
cord-290677-3gdcyrrz	213	23	)	)	-RRB-
cord-290677-3gdcyrrz	213	24	expression	expression	NN
cord-290677-3gdcyrrz	213	25	in	in	IN
cord-290677-3gdcyrrz	213	26	bone	bone	NN
cord-290677-3gdcyrrz	213	27	marrowderived	marrowderive	VBN
cord-290677-3gdcyrrz	213	28	non	non	NNP
cord-290677-3gdcyrrz	213	29	-	-	NNP
cord-290677-3gdcyrrz	213	30	T	t	JJ
cord-290677-3gdcyrrz	213	31	cells	cell	NNS
cord-290677-3gdcyrrz	213	32	is	be	VBZ
cord-290677-3gdcyrrz	213	33	required	require	VBN
cord-290677-3gdcyrrz	213	34	for	for	IN
cord-290677-3gdcyrrz	213	35	the	the	DT
cord-290677-3gdcyrrz	213	36	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	213	37	reflex	reflex	NN
cord-290677-3gdcyrrz	213	38	Influenza	influenza	NN
cord-290677-3gdcyrrz	213	39	-	-	,
cord-290677-3gdcyrrz	213	40	and	and	CC
cord-290677-3gdcyrrz	213	41	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	213	42	syncytial	syncytial	JJ
cord-290677-3gdcyrrz	213	43	virus	virus	NN
cord-290677-3gdcyrrz	213	44	-	-	HYPH
cord-290677-3gdcyrrz	213	45	associated	associate	VBN
cord-290677-3gdcyrrz	213	46	mortality	mortality	NN
cord-290677-3gdcyrrz	213	47	and	and	CC
cord-290677-3gdcyrrz	213	48	hospitalisations	hospitalisation	NNS
cord-290677-3gdcyrrz	213	49	Age	age	NN
cord-290677-3gdcyrrz	213	50	-	-	HYPH
cord-290677-3gdcyrrz	213	51	associated	associate	VBN
cord-290677-3gdcyrrz	213	52	increased	increase	VBN
cord-290677-3gdcyrrz	213	53	interleukin-6	interleukin-6	NNP
cord-290677-3gdcyrrz	213	54	gene	gene	NN
cord-290677-3gdcyrrz	213	55	expression	expression	NN
cord-290677-3gdcyrrz	213	56	,	,	,
cord-290677-3gdcyrrz	213	57	late	late	JJ
cord-290677-3gdcyrrz	213	58	-	-	HYPH
cord-290677-3gdcyrrz	213	59	life	life	NN
cord-290677-3gdcyrrz	213	60	diseases	disease	NNS
cord-290677-3gdcyrrz	213	61	,	,	,
cord-290677-3gdcyrrz	213	62	and	and	CC
cord-290677-3gdcyrrz	213	63	frailty	frailty	NN
cord-290677-3gdcyrrz	213	64	Autophagy	Autophagy	NNP
cord-290677-3gdcyrrz	213	65	controls	control	VBZ
cord-290677-3gdcyrrz	213	66	acquisition	acquisition	NN
cord-290677-3gdcyrrz	213	67	of	of	IN
cord-290677-3gdcyrrz	213	68	aging	age	VBG
cord-290677-3gdcyrrz	213	69	features	feature	NNS
cord-290677-3gdcyrrz	213	70	in	in	IN
cord-290677-3gdcyrrz	213	71	macrophages	macrophage	NNS
cord-290677-3gdcyrrz	213	72	Pulmonary	pulmonary	JJ
cord-290677-3gdcyrrz	213	73	macrophages	macrophage	NNS
cord-290677-3gdcyrrz	213	74	:	:	:
cord-290677-3gdcyrrz	213	75	key	key	JJ
cord-290677-3gdcyrrz	213	76	players	player	NNS
cord-290677-3gdcyrrz	213	77	in	in	IN
cord-290677-3gdcyrrz	213	78	the	the	DT
cord-290677-3gdcyrrz	213	79	innate	innate	JJ
cord-290677-3gdcyrrz	213	80	defence	defence	NN
cord-290677-3gdcyrrz	213	81	of	of	IN
cord-290677-3gdcyrrz	213	82	the	the	DT
cord-290677-3gdcyrrz	213	83	airways	airway	NNS
cord-290677-3gdcyrrz	213	84	Ageing	ageing	NN
cord-290677-3gdcyrrz	213	85	and	and	CC
cord-290677-3gdcyrrz	213	86	life	life	NN
cord-290677-3gdcyrrz	213	87	-	-	HYPH
cord-290677-3gdcyrrz	213	88	long	long	JJ
cord-290677-3gdcyrrz	213	89	maintenance	maintenance	NN
cord-290677-3gdcyrrz	213	90	of	of	IN
cord-290677-3gdcyrrz	213	91	T	t	NN
cord-290677-3gdcyrrz	213	92	-	-	HYPH
cord-290677-3gdcyrrz	213	93	cell	cell	NN
cord-290677-3gdcyrrz	213	94	subsets	subset	NNS
cord-290677-3gdcyrrz	213	95	in	in	IN
cord-290677-3gdcyrrz	213	96	the	the	DT
cord-290677-3gdcyrrz	213	97	face	face	NN
cord-290677-3gdcyrrz	213	98	of	of	IN
cord-290677-3gdcyrrz	213	99	latent	latent	JJ
cord-290677-3gdcyrrz	213	100	persistent	persistent	JJ
cord-290677-3gdcyrrz	213	101	infections	infection	NNS
cord-290677-3gdcyrrz	214	1	The	the	DT
cord-290677-3gdcyrrz	214	2	impact	impact	NN
cord-290677-3gdcyrrz	214	3	of	of	IN
cord-290677-3gdcyrrz	214	4	ageing	age	VBG
cord-290677-3gdcyrrz	214	5	on	on	IN
cord-290677-3gdcyrrz	214	6	natural	natural	JJ
cord-290677-3gdcyrrz	214	7	killer	killer	NN
cord-290677-3gdcyrrz	214	8	cell	cell	NN
cord-290677-3gdcyrrz	214	9	function	function	NN
cord-290677-3gdcyrrz	214	10	and	and	CC
cord-290677-3gdcyrrz	214	11	potential	potential	JJ
cord-290677-3gdcyrrz	214	12	consequences	consequence	NNS
cord-290677-3gdcyrrz	214	13	for	for	IN
cord-290677-3gdcyrrz	214	14	health	health	NN
cord-290677-3gdcyrrz	214	15	in	in	IN
cord-290677-3gdcyrrz	214	16	older	old	JJR
cord-290677-3gdcyrrz	214	17	adults	adult	NNS
cord-290677-3gdcyrrz	215	1	Aging	age	VBG
cord-290677-3gdcyrrz	215	2	and	and	CC
cord-290677-3gdcyrrz	215	3	the	the	DT
cord-290677-3gdcyrrz	215	4	immune	immune	JJ
cord-290677-3gdcyrrz	215	5	system	system	NN
cord-290677-3gdcyrrz	215	6	:	:	:
cord-290677-3gdcyrrz	215	7	the	the	DT
cord-290677-3gdcyrrz	215	8	impact	impact	NN
cord-290677-3gdcyrrz	215	9	of	of	IN
cord-290677-3gdcyrrz	215	10	immunosenescence	immunosenescence	NN
cord-290677-3gdcyrrz	215	11	on	on	IN
cord-290677-3gdcyrrz	215	12	viral	viral	JJ
cord-290677-3gdcyrrz	215	13	infection	infection	NN
cord-290677-3gdcyrrz	215	14	,	,	,
cord-290677-3gdcyrrz	215	15	immunity	immunity	NN
cord-290677-3gdcyrrz	215	16	and	and	CC
cord-290677-3gdcyrrz	215	17	vaccine	vaccine	NN
cord-290677-3gdcyrrz	215	18	immunogenicity	immunogenicity	NN
cord-290677-3gdcyrrz	216	1	Immunosenescence	immunosenescence	RB
cord-290677-3gdcyrrz	216	2	:	:	:
cord-290677-3gdcyrrz	216	3	implications	implication	NNS
cord-290677-3gdcyrrz	216	4	for	for	IN
cord-290677-3gdcyrrz	216	5	response	response	NN
cord-290677-3gdcyrrz	216	6	to	to	IN
cord-290677-3gdcyrrz	216	7	infection	infection	NN
cord-290677-3gdcyrrz	216	8	and	and	CC
cord-290677-3gdcyrrz	216	9	vaccination	vaccination	NN
cord-290677-3gdcyrrz	216	10	in	in	IN
cord-290677-3gdcyrrz	216	11	older	old	JJR
cord-290677-3gdcyrrz	216	12	people	people	NNS
cord-290677-3gdcyrrz	217	1	HIV	HIV	NNP
cord-290677-3gdcyrrz	217	2	-	-	HYPH
cord-290677-3gdcyrrz	217	3	specific	specific	JJ
cord-290677-3gdcyrrz	217	4	CD8	CD8	NNP
cord-290677-3gdcyrrz	217	5	+	+	CC
cord-290677-3gdcyrrz	217	6	T	T	NNP
cord-290677-3gdcyrrz	217	7	cells	cell	NNS
cord-290677-3gdcyrrz	217	8	exhibit	exhibit	VBP
cord-290677-3gdcyrrz	217	9	reduced	reduce	VBN
cord-290677-3gdcyrrz	217	10	and	and	CC
cord-290677-3gdcyrrz	217	11	differentially	differentially	RB
cord-290677-3gdcyrrz	217	12	regulated	regulate	VBN
cord-290677-3gdcyrrz	217	13	cytolytic	cytolytic	JJ
cord-290677-3gdcyrrz	217	14	activity	activity	NN
cord-290677-3gdcyrrz	217	15	in	in	IN
cord-290677-3gdcyrrz	217	16	lymphoid	lymphoid	JJ
cord-290677-3gdcyrrz	217	17	tissue	tissue	NN
cord-290677-3gdcyrrz	217	18	Harnessing	harness	VBG
cord-290677-3gdcyrrz	217	19	CD8	CD8	NNP
cord-290677-3gdcyrrz	217	20	+	+	CC
cord-290677-3gdcyrrz	217	21	T	T	NNP
cord-290677-3gdcyrrz	217	22	cells	cell	NNS
cord-290677-3gdcyrrz	217	23	under	under	IN
cord-290677-3gdcyrrz	218	1	HIV	HIV	NNP
cord-290677-3gdcyrrz	218	2	antiretroviral	antiretroviral	JJ
cord-290677-3gdcyrrz	218	3	therapy	therapy	NN
cord-290677-3gdcyrrz	218	4	Steroid	steroid	NN
cord-290677-3gdcyrrz	218	5	resistant	resistant	JJ
cord-290677-3gdcyrrz	218	6	CD8	CD8	NNS
cord-290677-3gdcyrrz	218	7	+	+	CC
cord-290677-3gdcyrrz	219	1	CD28	CD28	NNP
cord-290677-3gdcyrrz	219	2	null	null	JJ
cord-290677-3gdcyrrz	220	1	NKT	NKT	NNP
cord-290677-3gdcyrrz	220	2	-	-	HYPH
cord-290677-3gdcyrrz	220	3	like	like	JJ
cord-290677-3gdcyrrz	220	4	pro	pro	JJ
cord-290677-3gdcyrrz	220	5	-	-	JJ
cord-290677-3gdcyrrz	220	6	inflammatory	inflammatory	JJ
cord-290677-3gdcyrrz	220	7	cytotoxic	cytotoxic	JJ
cord-290677-3gdcyrrz	220	8	cells	cell	NNS
cord-290677-3gdcyrrz	220	9	in	in	IN
cord-290677-3gdcyrrz	220	10	chronic	chronic	JJ
cord-290677-3gdcyrrz	220	11	obstructive	obstructive	JJ
cord-290677-3gdcyrrz	220	12	pulmonary	pulmonary	JJ
cord-290677-3gdcyrrz	220	13	disease	disease	NN
cord-290677-3gdcyrrz	220	14	Effect	effect	NN
cord-290677-3gdcyrrz	220	15	of	of	IN
cord-290677-3gdcyrrz	220	16	aging	age	VBG
cord-290677-3gdcyrrz	220	17	on	on	IN
cord-290677-3gdcyrrz	220	18	gender	gender	NN
cord-290677-3gdcyrrz	220	19	differences	difference	NNS
cord-290677-3gdcyrrz	220	20	in	in	IN
cord-290677-3gdcyrrz	220	21	neural	neural	JJ
cord-290677-3gdcyrrz	220	22	control	control	NN
cord-290677-3gdcyrrz	220	23	of	of	IN
cord-290677-3gdcyrrz	220	24	heart	heart	NN
cord-290677-3gdcyrrz	220	25	rate	rate	NN
cord-290677-3gdcyrrz	220	26	Aging	aging	NN
cord-290677-3gdcyrrz	220	27	of	of	IN
cord-290677-3gdcyrrz	220	28	the	the	DT
cord-290677-3gdcyrrz	220	29	autonomic	autonomic	JJ
cord-290677-3gdcyrrz	220	30	nervous	nervous	JJ
cord-290677-3gdcyrrz	220	31	system	system	NN
cord-290677-3gdcyrrz	220	32	and	and	CC
cord-290677-3gdcyrrz	220	33	possible	possible	JJ
cord-290677-3gdcyrrz	220	34	improvements	improvement	NNS
cord-290677-3gdcyrrz	220	35	in	in	IN
cord-290677-3gdcyrrz	220	36	autonomic	autonomic	JJ
cord-290677-3gdcyrrz	220	37	activity	activity	NN
cord-290677-3gdcyrrz	220	38	using	use	VBG
cord-290677-3gdcyrrz	220	39	somatic	somatic	JJ
cord-290677-3gdcyrrz	220	40	afferent	afferent	JJ
cord-290677-3gdcyrrz	220	41	stimulation	stimulation	NN
cord-290677-3gdcyrrz	220	42	Changes	change	NNS
cord-290677-3gdcyrrz	220	43	in	in	IN
cord-290677-3gdcyrrz	220	44	vagal	vagal	JJ
cord-290677-3gdcyrrz	220	45	activity	activity	NN
cord-290677-3gdcyrrz	220	46	and	and	CC
cord-290677-3gdcyrrz	220	47	response	response	NN
cord-290677-3gdcyrrz	220	48	to	to	IN
cord-290677-3gdcyrrz	220	49	muscarinic	muscarinic	JJ
cord-290677-3gdcyrrz	220	50	receptor	receptor	NN
cord-290677-3gdcyrrz	220	51	agonists	agonist	NNS
cord-290677-3gdcyrrz	220	52	with	with	IN
cord-290677-3gdcyrrz	220	53	age	age	NN
cord-290677-3gdcyrrz	220	54	Effects	effect	NNS
cord-290677-3gdcyrrz	220	55	of	of	IN
cord-290677-3gdcyrrz	220	56	transcutaneous	transcutaneous	JJ
cord-290677-3gdcyrrz	220	57	vagus	vagus	NN
cord-290677-3gdcyrrz	220	58	nerve	nerve	NN
cord-290677-3gdcyrrz	220	59	stimulation	stimulation	NN
cord-290677-3gdcyrrz	220	60	in	in	IN
cord-290677-3gdcyrrz	220	61	individuals	individual	NNS
cord-290677-3gdcyrrz	220	62	aged	age	VBN
cord-290677-3gdcyrrz	220	63	55	55	CD
cord-290677-3gdcyrrz	220	64	years	year	NNS
cord-290677-3gdcyrrz	220	65	or	or	CC
cord-290677-3gdcyrrz	220	66	above	above	RB
cord-290677-3gdcyrrz	220	67	:	:	:
cord-290677-3gdcyrrz	220	68	potential	potential	JJ
cord-290677-3gdcyrrz	220	69	benefits	benefit	NNS
cord-290677-3gdcyrrz	220	70	of	of	IN
cord-290677-3gdcyrrz	220	71	daily	daily	JJ
cord-290677-3gdcyrrz	220	72	stimulation	stimulation	NN
cord-290677-3gdcyrrz	220	73	Vagus	Vagus	NNP
cord-290677-3gdcyrrz	220	74	nerve	nerve	NN
cord-290677-3gdcyrrz	220	75	and	and	CC
cord-290677-3gdcyrrz	220	76	vagus	vagus	NN
cord-290677-3gdcyrrz	220	77	nerve	nerve	NN
cord-290677-3gdcyrrz	220	78	stimulation	stimulation	NN
cord-290677-3gdcyrrz	220	79	,	,	,
cord-290677-3gdcyrrz	220	80	a	a	DT
cord-290677-3gdcyrrz	220	81	comprehensive	comprehensive	JJ
cord-290677-3gdcyrrz	220	82	review	review	NN
cord-290677-3gdcyrrz	220	83	:	:	:
cord-290677-3gdcyrrz	220	84	part	part	NN
cord-290677-3gdcyrrz	221	1	I	-PRON-	PRP
cord-290677-3gdcyrrz	221	2	SARS	SARS	NNP
cord-290677-3gdcyrrz	221	3	-	-	HYPH
cord-290677-3gdcyrrz	221	4	CoV-2	CoV-2	NNP
cord-290677-3gdcyrrz	221	5	and	and	CC
cord-290677-3gdcyrrz	221	6	COVID-19	covid-19	VB
cord-290677-3gdcyrrz	221	7	in	in	IN
cord-290677-3gdcyrrz	221	8	older	old	JJR
cord-290677-3gdcyrrz	221	9	adults	adult	NNS
cord-290677-3gdcyrrz	222	1	:	:	:
cord-290677-3gdcyrrz	222	2	what	what	WP
cord-290677-3gdcyrrz	222	3	we	-PRON-	PRP
cord-290677-3gdcyrrz	222	4	may	may	MD
cord-290677-3gdcyrrz	222	5	expect	expect	VB
cord-290677-3gdcyrrz	222	6	regarding	regard	VBG
cord-290677-3gdcyrrz	222	7	pathogenesis	pathogenesis	NN
cord-290677-3gdcyrrz	222	8	,	,	,
cord-290677-3gdcyrrz	222	9	immune	immune	JJ
cord-290677-3gdcyrrz	222	10	responses	response	NNS
cord-290677-3gdcyrrz	222	11	,	,	,
cord-290677-3gdcyrrz	222	12	and	and	CC
cord-290677-3gdcyrrz	222	13	outcomes	outcome	NNS
cord-290677-3gdcyrrz	223	1	The	the	DT
cord-290677-3gdcyrrz	223	2	international	international	JJ
cord-290677-3gdcyrrz	223	3	European	European	NNP
cord-290677-3gdcyrrz	223	4	Academy	Academy	NNP
cord-290677-3gdcyrrz	223	5	of	of	IN
cord-290677-3gdcyrrz	223	6	Neurology	Neurology	NNP
cord-290677-3gdcyrrz	223	7	survey	survey	NN
cord-290677-3gdcyrrz	223	8	on	on	IN
cord-290677-3gdcyrrz	223	9	neurological	neurological	JJ
cord-290677-3gdcyrrz	223	10	symptoms	symptom	NNS
cord-290677-3gdcyrrz	223	11	in	in	IN
cord-290677-3gdcyrrz	223	12	patients	patient	NNS
cord-290677-3gdcyrrz	223	13	with	with	IN
cord-290677-3gdcyrrz	223	14	COVID-19	covid-19	JJ
cord-290677-3gdcyrrz	223	15	infection	infection	NN
cord-290677-3gdcyrrz	223	16	Muscarinic	Muscarinic	NNP
cord-290677-3gdcyrrz	223	17	receptor	receptor	NN
cord-290677-3gdcyrrz	223	18	antagonists	antagonist	NNS
cord-290677-3gdcyrrz	223	19	:	:	:
cord-290677-3gdcyrrz	223	20	effects	effect	NNS
cord-290677-3gdcyrrz	223	21	on	on	IN
cord-290677-3gdcyrrz	223	22	pulmonary	pulmonary	JJ
cord-290677-3gdcyrrz	223	23	function	function	NN
cord-290677-3gdcyrrz	223	24	Sympathetic	sympathetic	JJ
cord-290677-3gdcyrrz	223	25	versus	versus	IN
cord-290677-3gdcyrrz	223	26	parasympathetic	parasympathetic	JJ
cord-290677-3gdcyrrz	223	27	nervous	nervous	JJ
cord-290677-3gdcyrrz	223	28	regulation	regulation	NN
cord-290677-3gdcyrrz	223	29	of	of	IN
cord-290677-3gdcyrrz	223	30	airways	airway	NNS
cord-290677-3gdcyrrz	223	31	in	in	IN
cord-290677-3gdcyrrz	223	32	dogs	dog	NNS
cord-290677-3gdcyrrz	223	33	Nervous	nervous	JJ
cord-290677-3gdcyrrz	223	34	control	control	NN
cord-290677-3gdcyrrz	223	35	of	of	IN
cord-290677-3gdcyrrz	223	36	mucin	mucin	NN
cord-290677-3gdcyrrz	223	37	secretion	secretion	NN
cord-290677-3gdcyrrz	223	38	into	into	IN
cord-290677-3gdcyrrz	223	39	human	human	JJ
cord-290677-3gdcyrrz	223	40	bronchi	bronchi	NN
cord-290677-3gdcyrrz	224	1	On	on	IN
cord-290677-3gdcyrrz	224	2	muscarinic	muscarinic	JJ
cord-290677-3gdcyrrz	224	3	control	control	NN
cord-290677-3gdcyrrz	224	4	of	of	IN
cord-290677-3gdcyrrz	224	5	neurogenic	neurogenic	JJ
cord-290677-3gdcyrrz	224	6	mucus	mucus	NN
cord-290677-3gdcyrrz	224	7	secretion	secretion	NN
cord-290677-3gdcyrrz	224	8	in	in	IN
cord-290677-3gdcyrrz	224	9	ferret	ferret	JJ
cord-290677-3gdcyrrz	224	10	trachea	trachea	NN
cord-290677-3gdcyrrz	224	11	Parasympathetic	parasympathetic	JJ
cord-290677-3gdcyrrz	224	12	nervous	nervous	JJ
cord-290677-3gdcyrrz	224	13	control	control	NN
cord-290677-3gdcyrrz	224	14	of	of	IN
cord-290677-3gdcyrrz	224	15	tracheal	tracheal	JJ
cord-290677-3gdcyrrz	224	16	vascular	vascular	JJ
cord-290677-3gdcyrrz	224	17	resistance	resistance	NN
cord-290677-3gdcyrrz	224	18	in	in	IN
cord-290677-3gdcyrrz	224	19	the	the	DT
cord-290677-3gdcyrrz	224	20	dog	dog	NN
cord-290677-3gdcyrrz	224	21	Acetylcholine	acetylcholine	NN
cord-290677-3gdcyrrz	224	22	via	via	IN
cord-290677-3gdcyrrz	224	23	muscarinic	muscarinic	JJ
cord-290677-3gdcyrrz	224	24	receptors	receptor	NNS
cord-290677-3gdcyrrz	224	25	inhibits	inhibit	VBZ
cord-290677-3gdcyrrz	224	26	histamine	histamine	NN
cord-290677-3gdcyrrz	224	27	release	release	NN
cord-290677-3gdcyrrz	224	28	from	from	IN
cord-290677-3gdcyrrz	224	29	human	human	JJ
cord-290677-3gdcyrrz	224	30	isolated	isolate	VBN
cord-290677-3gdcyrrz	224	31	bronchi	bronchi	NN
cord-290677-3gdcyrrz	224	32	Muscarinic	Muscarinic	NNP
cord-290677-3gdcyrrz	224	33	control	control	NN
cord-290677-3gdcyrrz	224	34	of	of	IN
cord-290677-3gdcyrrz	224	35	histamine	histamine	NN
cord-290677-3gdcyrrz	224	36	release	release	NN
cord-290677-3gdcyrrz	224	37	from	from	IN
cord-290677-3gdcyrrz	224	38	airways	airway	NNS
cord-290677-3gdcyrrz	224	39	.	.	.
cord-290677-3gdcyrrz	225	1	Inhibitory	inhibitory	JJ
cord-290677-3gdcyrrz	225	2	M1-receptors	m1-receptor	NNS
cord-290677-3gdcyrrz	225	3	in	in	IN
cord-290677-3gdcyrrz	225	4	human	human	JJ
cord-290677-3gdcyrrz	225	5	bronchi	bronchi	NN
cord-290677-3gdcyrrz	225	6	but	but	CC
cord-290677-3gdcyrrz	226	1	absence	absence	NN
cord-290677-3gdcyrrz	226	2	in	in	IN
cord-290677-3gdcyrrz	226	3	rat	rat	NN
cord-290677-3gdcyrrz	226	4	trachea	trachea	NN
cord-290677-3gdcyrrz	226	5	Glucocorticoids	Glucocorticoids	NNP
cord-290677-3gdcyrrz	226	6	mediate	mediate	VBP
cord-290677-3gdcyrrz	226	7	reduction	reduction	NN
cord-290677-3gdcyrrz	226	8	of	of	IN
cord-290677-3gdcyrrz	226	9	epithelial	epithelial	JJ
cord-290677-3gdcyrrz	226	10	acetylcholine	acetylcholine	NN
cord-290677-3gdcyrrz	226	11	content	content	NN
cord-290677-3gdcyrrz	226	12	in	in	IN
cord-290677-3gdcyrrz	226	13	the	the	DT
cord-290677-3gdcyrrz	226	14	airways	airway	NNS
cord-290677-3gdcyrrz	226	15	of	of	IN
cord-290677-3gdcyrrz	226	16	rats	rat	NNS
cord-290677-3gdcyrrz	226	17	and	and	CC
cord-290677-3gdcyrrz	227	1	humans	human	NNS
cord-290677-3gdcyrrz	227	2	A	a	DT
cord-290677-3gdcyrrz	227	3	nicotinic	nicotinic	JJ
cord-290677-3gdcyrrz	227	4	hypothesis	hypothesis	NN
cord-290677-3gdcyrrz	227	5	for	for	IN
cord-290677-3gdcyrrz	227	6	Covid-19	Covid-19	NNP
cord-290677-3gdcyrrz	227	7	with	with	IN
cord-290677-3gdcyrrz	227	8	preventive	preventive	JJ
cord-290677-3gdcyrrz	227	9	and	and	CC
cord-290677-3gdcyrrz	227	10	therapeutic	therapeutic	JJ
cord-290677-3gdcyrrz	227	11	implications	implication	NNS
cord-290677-3gdcyrrz	227	12	The	the	DT
cord-290677-3gdcyrrz	227	13	vagus	vagus	NN
cord-290677-3gdcyrrz	227	14	nerve	nerve	NN
cord-290677-3gdcyrrz	227	15	and	and	CC
cord-290677-3gdcyrrz	227	16	nicotinic	nicotinic	JJ
cord-290677-3gdcyrrz	227	17	receptors	receptor	NNS
cord-290677-3gdcyrrz	227	18	modulate	modulate	VBP
cord-290677-3gdcyrrz	227	19	experimental	experimental	JJ
cord-290677-3gdcyrrz	227	20	pancreatitis	pancreatitis	NN
cord-290677-3gdcyrrz	227	21	severity	severity	NN
cord-290677-3gdcyrrz	227	22	in	in	IN
cord-290677-3gdcyrrz	227	23	mice	mouse	NNS
cord-290677-3gdcyrrz	228	1	The	the	DT
cord-290677-3gdcyrrz	228	2	cholinergic	cholinergic	JJ
cord-290677-3gdcyrrz	228	3	antiinflammatory	antiinflammatory	JJ
cord-290677-3gdcyrrz	228	4	pathway	pathway	NN
cord-290677-3gdcyrrz	228	5	regulates	regulate	VBZ
cord-290677-3gdcyrrz	228	6	the	the	DT
cord-290677-3gdcyrrz	228	7	host	host	NN
cord-290677-3gdcyrrz	228	8	response	response	NN
cord-290677-3gdcyrrz	228	9	during	during	IN
cord-290677-3gdcyrrz	228	10	septic	septic	JJ
cord-290677-3gdcyrrz	228	11	peritonitis	peritonitis	NN
cord-290677-3gdcyrrz	229	1	The	the	DT
cord-290677-3gdcyrrz	229	2	role	role	NN
cord-290677-3gdcyrrz	229	3	of	of	IN
cord-290677-3gdcyrrz	229	4	afferent	afferent	JJ
cord-290677-3gdcyrrz	229	5	pulmonary	pulmonary	JJ
cord-290677-3gdcyrrz	229	6	innervation	innervation	NN
cord-290677-3gdcyrrz	229	7	in	in	IN
cord-290677-3gdcyrrz	229	8	poor	poor	JJ
cord-290677-3gdcyrrz	229	9	prognosis	prognosis	NN
cord-290677-3gdcyrrz	229	10	of	of	IN
cord-290677-3gdcyrrz	229	11	acute	acute	JJ
cord-290677-3gdcyrrz	229	12	respiratory	respiratory	JJ
cord-290677-3gdcyrrz	229	13	distress	distress	NN
cord-290677-3gdcyrrz	229	14	syndrome	syndrome	NN
cord-290677-3gdcyrrz	229	15	in	in	IN
cord-290677-3gdcyrrz	229	16	COVID-19	COVID-19	NNP
cord-290677-3gdcyrrz	229	17	patients	patient	NNS
cord-290677-3gdcyrrz	229	18	and	and	CC
cord-290677-3gdcyrrz	229	19	proposed	propose	VBN
cord-290677-3gdcyrrz	229	20	use	use	NN
cord-290677-3gdcyrrz	229	21	of	of	IN
cord-290677-3gdcyrrz	229	22	resiniferatoxin	resiniferatoxin	NNP
cord-290677-3gdcyrrz	229	23	(	(	-LRB-
cord-290677-3gdcyrrz	229	24	RTX	RTX	NNP
cord-290677-3gdcyrrz	229	25	)	)	-RRB-
cord-290677-3gdcyrrz	229	26	to	to	TO
cord-290677-3gdcyrrz	229	27	improve	improve	VB
cord-290677-3gdcyrrz	229	28	patient	patient	JJ
cord-290677-3gdcyrrz	229	29	outcomes	outcome	NNS
cord-290677-3gdcyrrz	229	30	in	in	IN
cord-290677-3gdcyrrz	229	31	advanced	advanced	JJ
cord-290677-3gdcyrrz	229	32	disease	disease	NN
cord-290677-3gdcyrrz	229	33	state	state	NN
cord-290677-3gdcyrrz	229	34	:	:	:
cord-290677-3gdcyrrz	229	35	a	a	DT
cord-290677-3gdcyrrz	229	36	review	review	NN
cord-290677-3gdcyrrz	229	37	Deletion	deletion	NN
cord-290677-3gdcyrrz	229	38	of	of	IN
cord-290677-3gdcyrrz	229	39	vanilloid	vanilloid	NNP
cord-290677-3gdcyrrz	229	40	receptor	receptor	NN
cord-290677-3gdcyrrz	229	41	1-expressing	1-expressing	CD
cord-290677-3gdcyrrz	229	42	primary	primary	JJ
cord-290677-3gdcyrrz	229	43	afferent	afferent	JJ
cord-290677-3gdcyrrz	229	44	neurons	neuron	NNS
cord-290677-3gdcyrrz	229	45	for	for	IN
cord-290677-3gdcyrrz	229	46	pain	pain	NN
cord-290677-3gdcyrrz	229	47	control	control	NN
cord-290677-3gdcyrrz	229	48	Human	human	JJ
cord-290677-3gdcyrrz	229	49	substance	substance	NN
cord-290677-3gdcyrrz	229	50	P	p	NN
cord-290677-3gdcyrrz	229	51	receptor	receptor	NN
cord-290677-3gdcyrrz	229	52	binding	binding	NN
cord-290677-3gdcyrrz	229	53	mode	mode	NN
cord-290677-3gdcyrrz	229	54	of	of	IN
cord-290677-3gdcyrrz	229	55	the	the	DT
cord-290677-3gdcyrrz	229	56	antagonist	antagonist	NN
cord-290677-3gdcyrrz	229	57	drug	drug	NN
cord-290677-3gdcyrrz	229	58	aprepitant	aprepitant	NN
cord-290677-3gdcyrrz	229	59	by	by	IN
cord-290677-3gdcyrrz	229	60	NMR	NMR	NNP
cord-290677-3gdcyrrz	229	61	and	and	CC
cord-290677-3gdcyrrz	229	62	crystallography	crystallography	NN
cord-290677-3gdcyrrz	229	63	Aprepitant	Aprepitant	NNP
cord-290677-3gdcyrrz	229	64	:	:	:
cord-290677-3gdcyrrz	229	65	a	a	DT
cord-290677-3gdcyrrz	229	66	review	review	NN
cord-290677-3gdcyrrz	229	67	of	of	IN
cord-290677-3gdcyrrz	229	68	its	-PRON-	PRP$
cord-290677-3gdcyrrz	229	69	use	use	NN
cord-290677-3gdcyrrz	229	70	in	in	IN
cord-290677-3gdcyrrz	229	71	the	the	DT
cord-290677-3gdcyrrz	229	72	prevention	prevention	NN
cord-290677-3gdcyrrz	229	73	of	of	IN
cord-290677-3gdcyrrz	229	74	nausea	nausea	NN
cord-290677-3gdcyrrz	229	75	and	and	CC
cord-290677-3gdcyrrz	229	76	vomiting	vomit	VBG
cord-290677-3gdcyrrz	229	77	The	the	DT
cord-290677-3gdcyrrz	229	78	authors	author	NNS
cord-290677-3gdcyrrz	229	79	thank	thank	VBP
cord-290677-3gdcyrrz	229	80	P.	P.	NNP
cord-290677-3gdcyrrz	229	81	Muraro	Muraro	NNP
cord-290677-3gdcyrrz	229	82	,	,	,
cord-290677-3gdcyrrz	229	83	M.	M.	NNP
cord-290677-3gdcyrrz	229	84	Botto	Botto	NNP
cord-290677-3gdcyrrz	229	85	and	and	CC
cord-290677-3gdcyrrz	229	86	R.	R.	NNP
cord-290677-3gdcyrrz	229	87	Reynolds	Reynolds	NNP
cord-290677-3gdcyrrz	229	88	for	for	IN
cord-290677-3gdcyrrz	229	89	their	-PRON-	PRP$
cord-290677-3gdcyrrz	229	90	valuable	valuable	JJ
cord-290677-3gdcyrrz	229	91	critical	critical	JJ
cord-290677-3gdcyrrz	229	92	insight	insight	NN
cord-290677-3gdcyrrz	229	93	and	and	CC
cord-290677-3gdcyrrz	229	94	suggestions	suggestion	NNS
cord-290677-3gdcyrrz	229	95	.	.	.
cord-290677-3gdcyrrz	230	1	Both	both	DT
cord-290677-3gdcyrrz	230	2	authors	author	NNS
cord-290677-3gdcyrrz	230	3	contributed	contribute	VBD
cord-290677-3gdcyrrz	230	4	to	to	IN
cord-290677-3gdcyrrz	230	5	all	all	DT
cord-290677-3gdcyrrz	230	6	aspects	aspect	NNS
cord-290677-3gdcyrrz	230	7	of	of	IN
cord-290677-3gdcyrrz	230	8	the	the	DT
cord-290677-3gdcyrrz	230	9	article	article	NN
cord-290677-3gdcyrrz	230	10	.	.	.
cord-290677-3gdcyrrz	231	1	The	the	DT
cord-290677-3gdcyrrz	231	2	authors	author	NNS
cord-290677-3gdcyrrz	231	3	declare	declare	VBP
cord-290677-3gdcyrrz	231	4	no	no	DT
cord-290677-3gdcyrrz	231	5	competing	compete	VBG
cord-290677-3gdcyrrz	231	6	interests	interest	NNS
cord-290677-3gdcyrrz	231	7	.	.	.
cord-290677-3gdcyrrz	232	1	Nature	Nature	NNP
cord-290677-3gdcyrrz	232	2	Reviews	Reviews	NNPS
cord-290677-3gdcyrrz	232	3	Neurology	Neurology	NNP
cord-290677-3gdcyrrz	232	4	thanks	thank	NNS
cord-290677-3gdcyrrz	232	5	J.	J.	NNP
cord-290677-3gdcyrrz	232	6	Sellner	Sellner	NNP
cord-290677-3gdcyrrz	232	7	,	,	,
cord-290677-3gdcyrrz	232	8	F.	F.	NNP
cord-290677-3gdcyrrz	232	9	Chigr	Chigr	NNPS
cord-290677-3gdcyrrz	232	10	and	and	CC
cord-290677-3gdcyrrz	232	11	other	other	JJ
cord-290677-3gdcyrrz	233	1	,	,	,
cord-290677-3gdcyrrz	233	2	anonymous	anonymous	JJ
cord-290677-3gdcyrrz	233	3	,	,	,
cord-290677-3gdcyrrz	233	4	reviewer(s	reviewer(s	NNP
cord-290677-3gdcyrrz	233	5	)	)	-RRB-
cord-290677-3gdcyrrz	233	6	for	for	IN
cord-290677-3gdcyrrz	233	7	their	-PRON-	PRP$
cord-290677-3gdcyrrz	233	8	contribution	contribution	NN
cord-290677-3gdcyrrz	233	9	to	to	IN
cord-290677-3gdcyrrz	233	10	the	the	DT
cord-290677-3gdcyrrz	233	11	peer	peer	NN
cord-290677-3gdcyrrz	233	12	review	review	NN
cord-290677-3gdcyrrz	233	13	of	of	IN
cord-290677-3gdcyrrz	233	14	this	this	DT
cord-290677-3gdcyrrz	233	15	work	work	NN
cord-290677-3gdcyrrz	233	16	.	.	.
cord-290677-3gdcyrrz	234	1	Springer	Springer	NNP
cord-290677-3gdcyrrz	234	2	Nature	Nature	NNP
cord-290677-3gdcyrrz	234	3	remains	remain	VBZ
cord-290677-3gdcyrrz	234	4	neutral	neutral	JJ
cord-290677-3gdcyrrz	234	5	with	with	IN
cord-290677-3gdcyrrz	234	6	regard	regard	NN
cord-290677-3gdcyrrz	234	7	to	to	IN
cord-290677-3gdcyrrz	234	8	jurisdictional	jurisdictional	JJ
cord-290677-3gdcyrrz	234	9	claims	claim	NNS
cord-290677-3gdcyrrz	234	10	in	in	IN
cord-290677-3gdcyrrz	234	11	published	publish	VBN
cord-290677-3gdcyrrz	234	12	maps	map	NNS
cord-290677-3gdcyrrz	234	13	and	and	CC
cord-290677-3gdcyrrz	234	14	institutional	institutional	JJ
cord-290677-3gdcyrrz	234	15	affiliations	affiliation	NNS
cord-290677-3gdcyrrz	234	16	.	.	.