id sid tid token lemma pos cord-288020-vhtr3l0w 1 1 key key JJ cord-288020-vhtr3l0w 1 2 : : : cord-288020-vhtr3l0w 1 3 cord-288020-vhtr3l0w cord-288020-vhtr3l0w NN cord-288020-vhtr3l0w 2 1 authors author NNS cord-288020-vhtr3l0w 2 2 : : : cord-288020-vhtr3l0w 2 3 Côté Côté NNP cord-288020-vhtr3l0w 2 4 , , , cord-288020-vhtr3l0w 2 5 Andréanne Andréanne NNP cord-288020-vhtr3l0w 2 6 ; ; : cord-288020-vhtr3l0w 2 7 Ternacle Ternacle NNP cord-288020-vhtr3l0w 2 8 , , , cord-288020-vhtr3l0w 2 9 Julien Julien NNP cord-288020-vhtr3l0w 2 10 ; ; : cord-288020-vhtr3l0w 2 11 Pibarot Pibarot NNP cord-288020-vhtr3l0w 2 12 , , , cord-288020-vhtr3l0w 2 13 Philippe Philippe NNP cord-288020-vhtr3l0w 2 14 title title NN cord-288020-vhtr3l0w 2 15 : : : cord-288020-vhtr3l0w 2 16 Early early JJ cord-288020-vhtr3l0w 2 17 prediction prediction NN cord-288020-vhtr3l0w 2 18 of of IN cord-288020-vhtr3l0w 2 19 the the DT cord-288020-vhtr3l0w 2 20 risk risk NN cord-288020-vhtr3l0w 2 21 of of IN cord-288020-vhtr3l0w 2 22 severe severe JJ cord-288020-vhtr3l0w 2 23 coronavirus coronavirus NN cord-288020-vhtr3l0w 2 24 disease disease NN cord-288020-vhtr3l0w 2 25 2019 2019 CD cord-288020-vhtr3l0w 2 26 : : : cord-288020-vhtr3l0w 3 1 A a DT cord-288020-vhtr3l0w 3 2 key key JJ cord-288020-vhtr3l0w 3 3 step step NN cord-288020-vhtr3l0w 3 4 in in IN cord-288020-vhtr3l0w 3 5 therapeutic therapeutic JJ cord-288020-vhtr3l0w 3 6 decision decision NN cord-288020-vhtr3l0w 3 7 making make VBG cord-288020-vhtr3l0w 3 8 date date NN cord-288020-vhtr3l0w 3 9 : : : cord-288020-vhtr3l0w 3 10 2020 2020 CD cord-288020-vhtr3l0w 3 11 - - HYPH cord-288020-vhtr3l0w 3 12 08 08 CD cord-288020-vhtr3l0w 3 13 - - SYM cord-288020-vhtr3l0w 3 14 15 15 CD cord-288020-vhtr3l0w 3 15 journal journal NN cord-288020-vhtr3l0w 3 16 : : : cord-288020-vhtr3l0w 4 1 EBioMedicine ebiomedicine NN cord-288020-vhtr3l0w 4 2 DOI DOI NNP cord-288020-vhtr3l0w 4 3 : : : cord-288020-vhtr3l0w 4 4 10.1016 10.1016 CD cord-288020-vhtr3l0w 4 5 / / SYM cord-288020-vhtr3l0w 4 6 j.ebiom.2020.102948 j.ebiom.2020.102948 NN cord-288020-vhtr3l0w 4 7 sha sha NNP cord-288020-vhtr3l0w 4 8 : : : cord-288020-vhtr3l0w 4 9 26fdc6de719fdf960b3fa80032402c2deebac7e3 26fdc6de719fdf960b3fa80032402c2deebac7e3 NNP cord-288020-vhtr3l0w 4 10 doc_id doc_id CD cord-288020-vhtr3l0w 4 11 : : : cord-288020-vhtr3l0w 4 12 288020 288020 CD cord-288020-vhtr3l0w 4 13 cord_uid cord_uid NNS cord-288020-vhtr3l0w 4 14 : : : cord-288020-vhtr3l0w 5 1 vhtr3l0w vhtr3l0w JJ cord-288020-vhtr3l0w 6 1 nan nan NNP cord-288020-vhtr3l0w 6 2 Article Article NNP cord-288020-vhtr3l0w 6 3 History history NN cord-288020-vhtr3l0w 6 4 : : : cord-288020-vhtr3l0w 6 5 Received receive VBD cord-288020-vhtr3l0w 6 6 11 11 CD cord-288020-vhtr3l0w 6 7 July July NNP cord-288020-vhtr3l0w 6 8 2020 2020 CD cord-288020-vhtr3l0w 7 1 Accepted accept VBN cord-288020-vhtr3l0w 7 2 28 28 CD cord-288020-vhtr3l0w 7 3 July July NNP cord-288020-vhtr3l0w 7 4 2020 2020 CD cord-288020-vhtr3l0w 8 1 COVID-19 COVID-19 NNP cord-288020-vhtr3l0w 8 2 is be VBZ cord-288020-vhtr3l0w 8 3 caused cause VBN cord-288020-vhtr3l0w 8 4 by by IN cord-288020-vhtr3l0w 8 5 the the DT cord-288020-vhtr3l0w 8 6 SARS SARS NNP cord-288020-vhtr3l0w 8 7 - - HYPH cord-288020-vhtr3l0w 8 8 COV-2 COV-2 NNP cord-288020-vhtr3l0w 8 9 virus virus NN cord-288020-vhtr3l0w 8 10 and and CC cord-288020-vhtr3l0w 8 11 leads lead VBZ cord-288020-vhtr3l0w 8 12 to to IN cord-288020-vhtr3l0w 8 13 primarily primarily RB cord-288020-vhtr3l0w 8 14 respiratory respiratory JJ cord-288020-vhtr3l0w 8 15 symptoms symptom NNS cord-288020-vhtr3l0w 8 16 . . . cord-288020-vhtr3l0w 9 1 So so RB cord-288020-vhtr3l0w 9 2 far far RB cord-288020-vhtr3l0w 9 3 , , , cord-288020-vhtr3l0w 9 4 a a DT cord-288020-vhtr3l0w 9 5 wide wide JJ cord-288020-vhtr3l0w 9 6 range range NN cord-288020-vhtr3l0w 9 7 of of IN cord-288020-vhtr3l0w 9 8 clinical clinical JJ cord-288020-vhtr3l0w 9 9 manifestations manifestation NNS cord-288020-vhtr3l0w 9 10 have have VBP cord-288020-vhtr3l0w 9 11 been be VBN cord-288020-vhtr3l0w 9 12 reported report VBN cord-288020-vhtr3l0w 9 13 from from IN cord-288020-vhtr3l0w 9 14 complete complete JJ cord-288020-vhtr3l0w 9 15 lack lack NN cord-288020-vhtr3l0w 9 16 of of IN cord-288020-vhtr3l0w 9 17 symptoms symptom NNS cord-288020-vhtr3l0w 9 18 to to IN cord-288020-vhtr3l0w 9 19 life life NN cord-288020-vhtr3l0w 9 20 - - HYPH cord-288020-vhtr3l0w 9 21 threatening threaten VBG cord-288020-vhtr3l0w 9 22 multiple multiple JJ cord-288020-vhtr3l0w 9 23 organ organ NN cord-288020-vhtr3l0w 9 24 failure failure NN cord-288020-vhtr3l0w 9 25 . . . cord-288020-vhtr3l0w 10 1 Currently currently RB cord-288020-vhtr3l0w 10 2 , , , cord-288020-vhtr3l0w 10 3 therapeutic therapeutic JJ cord-288020-vhtr3l0w 10 4 management management NN cord-288020-vhtr3l0w 10 5 is be VBZ cord-288020-vhtr3l0w 10 6 mainly mainly RB cord-288020-vhtr3l0w 10 7 supportive supportive JJ cord-288020-vhtr3l0w 10 8 and and CC cord-288020-vhtr3l0w 10 9 primarily primarily RB cord-288020-vhtr3l0w 10 10 driven drive VBN cord-288020-vhtr3l0w 10 11 by by IN cord-288020-vhtr3l0w 10 12 the the DT cord-288020-vhtr3l0w 10 13 presence presence NN cord-288020-vhtr3l0w 10 14 and and CC cord-288020-vhtr3l0w 10 15 severity severity NN cord-288020-vhtr3l0w 10 16 of of IN cord-288020-vhtr3l0w 10 17 an an DT cord-288020-vhtr3l0w 10 18 individual individual NN cord-288020-vhtr3l0w 10 19 's 's POS cord-288020-vhtr3l0w 10 20 symptoms symptom NNS cord-288020-vhtr3l0w 10 21 . . . cord-288020-vhtr3l0w 11 1 It -PRON- PRP cord-288020-vhtr3l0w 11 2 is be VBZ cord-288020-vhtr3l0w 11 3 becoming become VBG cord-288020-vhtr3l0w 11 4 increasingly increasingly RB cord-288020-vhtr3l0w 11 5 obvious obvious JJ cord-288020-vhtr3l0w 11 6 that that IN cord-288020-vhtr3l0w 11 7 a a DT cord-288020-vhtr3l0w 11 8 substantial substantial JJ cord-288020-vhtr3l0w 11 9 proportion proportion NN cord-288020-vhtr3l0w 11 10 of of IN cord-288020-vhtr3l0w 11 11 patients patient NNS cord-288020-vhtr3l0w 11 12 initially initially RB cord-288020-vhtr3l0w 11 13 presenting present VBG cord-288020-vhtr3l0w 11 14 with with IN cord-288020-vhtr3l0w 11 15 mild mild JJ cord-288020-vhtr3l0w 11 16 symptoms symptom NNS cord-288020-vhtr3l0w 11 17 are be VBP cord-288020-vhtr3l0w 11 18 at at IN cord-288020-vhtr3l0w 11 19 increased increase VBN cord-288020-vhtr3l0w 11 20 risk risk NN cord-288020-vhtr3l0w 11 21 of of IN cord-288020-vhtr3l0w 11 22 developing develop VBG cord-288020-vhtr3l0w 11 23 severe severe JJ cord-288020-vhtr3l0w 11 24 disease disease NN cord-288020-vhtr3l0w 11 25 and and CC cord-288020-vhtr3l0w 11 26 would would MD cord-288020-vhtr3l0w 11 27 benefit benefit VB cord-288020-vhtr3l0w 11 28 from from IN cord-288020-vhtr3l0w 11 29 early early RB cord-288020-vhtr3l0w 11 30 and and CC cord-288020-vhtr3l0w 11 31 more more RBR cord-288020-vhtr3l0w 11 32 aggressive aggressive JJ cord-288020-vhtr3l0w 11 33 intervention intervention NN cord-288020-vhtr3l0w 11 34 . . . cord-288020-vhtr3l0w 12 1 There there EX cord-288020-vhtr3l0w 12 2 is be VBZ cord-288020-vhtr3l0w 12 3 thus thus RB cord-288020-vhtr3l0w 12 4 a a DT cord-288020-vhtr3l0w 12 5 need need NN cord-288020-vhtr3l0w 12 6 to to TO cord-288020-vhtr3l0w 12 7 develop develop VB cord-288020-vhtr3l0w 12 8 and and CC cord-288020-vhtr3l0w 12 9 validate validate VB cord-288020-vhtr3l0w 12 10 risk risk NN cord-288020-vhtr3l0w 12 11 stratification stratification NN cord-288020-vhtr3l0w 12 12 models model NNS cord-288020-vhtr3l0w 12 13 that that WDT cord-288020-vhtr3l0w 12 14 can can MD cord-288020-vhtr3l0w 12 15 provide provide VB cord-288020-vhtr3l0w 12 16 early early JJ cord-288020-vhtr3l0w 12 17 prediction prediction NN cord-288020-vhtr3l0w 12 18 of of IN cord-288020-vhtr3l0w 12 19 those those DT cord-288020-vhtr3l0w 12 20 individuals individual NNS cord-288020-vhtr3l0w 12 21 who who WP cord-288020-vhtr3l0w 12 22 are be VBP cord-288020-vhtr3l0w 12 23 at at IN cord-288020-vhtr3l0w 12 24 risk risk NN cord-288020-vhtr3l0w 12 25 of of IN cord-288020-vhtr3l0w 12 26 developing develop VBG cord-288020-vhtr3l0w 12 27 a a DT cord-288020-vhtr3l0w 12 28 severe severe JJ cord-288020-vhtr3l0w 12 29 disease disease NN cord-288020-vhtr3l0w 12 30 . . . cord-288020-vhtr3l0w 13 1 In in IN cord-288020-vhtr3l0w 13 2 an an DT cord-288020-vhtr3l0w 13 3 article article NN cord-288020-vhtr3l0w 13 4 published publish VBN cord-288020-vhtr3l0w 13 5 in in IN cord-288020-vhtr3l0w 13 6 the the DT cord-288020-vhtr3l0w 13 7 July July NNP cord-288020-vhtr3l0w 13 8 issue issue NN cord-288020-vhtr3l0w 13 9 of of IN cord-288020-vhtr3l0w 13 10 EBioMedicine EBioMedicine NNP cord-288020-vhtr3l0w 13 11 , , , cord-288020-vhtr3l0w 13 12 Xiao Xiao NNP cord-288020-vhtr3l0w 13 13 et et NNP cord-288020-vhtr3l0w 13 14 al al NNP cord-288020-vhtr3l0w 13 15 . . . cord-288020-vhtr3l0w 14 1 propose propose VB cord-288020-vhtr3l0w 14 2 a a DT cord-288020-vhtr3l0w 14 3 novel novel JJ cord-288020-vhtr3l0w 14 4 risk risk NN cord-288020-vhtr3l0w 14 5 score score NN cord-288020-vhtr3l0w 14 6 for for IN cord-288020-vhtr3l0w 14 7 this this DT cord-288020-vhtr3l0w 14 8 purpose purpose NN cord-288020-vhtr3l0w 14 9 ; ; : cord-288020-vhtr3l0w 14 10 the the DT cord-288020-vhtr3l0w 14 11 HNC HNC NNP cord-288020-vhtr3l0w 14 12 - - HYPH cord-288020-vhtr3l0w 14 13 LL LL NNP cord-288020-vhtr3l0w 14 14 score score NN cord-288020-vhtr3l0w 14 15 [ [ -LRB- cord-288020-vhtr3l0w 14 16 1 1 CD cord-288020-vhtr3l0w 14 17 ] ] -RRB- cord-288020-vhtr3l0w 14 18 . . . cord-288020-vhtr3l0w 15 1 Specifically specifically RB cord-288020-vhtr3l0w 15 2 , , , cord-288020-vhtr3l0w 15 3 the the DT cord-288020-vhtr3l0w 15 4 HNC HNC NNP cord-288020-vhtr3l0w 15 5 - - HYPH cord-288020-vhtr3l0w 15 6 LL LL NNP cord-288020-vhtr3l0w 15 7 score score NN cord-288020-vhtr3l0w 15 8 includes include VBZ cord-288020-vhtr3l0w 15 9 hypertension hypertension NN cord-288020-vhtr3l0w 15 10 , , , cord-288020-vhtr3l0w 15 11 neutrophil neutrophil NN cord-288020-vhtr3l0w 15 12 count count NN cord-288020-vhtr3l0w 15 13 , , , cord-288020-vhtr3l0w 15 14 C C NNP cord-288020-vhtr3l0w 15 15 - - HYPH cord-288020-vhtr3l0w 15 16 Reactive Reactive NNP cord-288020-vhtr3l0w 15 17 Protein Protein NNP cord-288020-vhtr3l0w 15 18 ( ( -LRB- cord-288020-vhtr3l0w 15 19 CRP CRP NNP cord-288020-vhtr3l0w 15 20 ) ) -RRB- cord-288020-vhtr3l0w 15 21 , , , cord-288020-vhtr3l0w 15 22 lymphocyte lymphocyte NN cord-288020-vhtr3l0w 15 23 count count NN cord-288020-vhtr3l0w 15 24 , , , cord-288020-vhtr3l0w 15 25 and and CC cord-288020-vhtr3l0w 15 26 lactate lactate NN cord-288020-vhtr3l0w 15 27 dehydrogenase dehydrogenase NN cord-288020-vhtr3l0w 15 28 . . . cord-288020-vhtr3l0w 16 1 Their -PRON- PRP$ cord-288020-vhtr3l0w 16 2 retrospective retrospective JJ cord-288020-vhtr3l0w 16 3 study study NN cord-288020-vhtr3l0w 16 4 included include VBD cord-288020-vhtr3l0w 16 5 690 690 CD cord-288020-vhtr3l0w 16 6 patients patient NNS cord-288020-vhtr3l0w 16 7 from from IN cord-288020-vhtr3l0w 16 8 hospitals hospital NNS cord-288020-vhtr3l0w 16 9 in in IN cord-288020-vhtr3l0w 16 10 Honghu Honghu NNP cord-288020-vhtr3l0w 16 11 and and CC cord-288020-vhtr3l0w 16 12 Nanchang Nanchang NNP cord-288020-vhtr3l0w 16 13 , , , cord-288020-vhtr3l0w 16 14 China China NNP cord-288020-vhtr3l0w 16 15 . . . cord-288020-vhtr3l0w 17 1 The the DT cord-288020-vhtr3l0w 17 2 stratification stratification NN cord-288020-vhtr3l0w 17 3 results result NNS cord-288020-vhtr3l0w 17 4 showed show VBD cord-288020-vhtr3l0w 17 5 good good JJ cord-288020-vhtr3l0w 17 6 accuracy accuracy NN cord-288020-vhtr3l0w 17 7 ( ( -LRB- cord-288020-vhtr3l0w 17 8 Area area NN cord-288020-vhtr3l0w 17 9 under under IN cord-288020-vhtr3l0w 17 10 the the DT cord-288020-vhtr3l0w 17 11 Receiver Receiver NNP cord-288020-vhtr3l0w 17 12 Operating Operating NNP cord-288020-vhtr3l0w 17 13 Characteristic characteristic JJ cord-288020-vhtr3l0w 17 14 curve curve NN cord-288020-vhtr3l0w 17 15 > > XX cord-288020-vhtr3l0w 17 16 0.85 0.85 CD cord-288020-vhtr3l0w 17 17 ) ) -RRB- cord-288020-vhtr3l0w 17 18 to to TO cord-288020-vhtr3l0w 17 19 predict predict VB cord-288020-vhtr3l0w 17 20 severe severe JJ cord-288020-vhtr3l0w 17 21 disease disease NN cord-288020-vhtr3l0w 17 22 in in IN cord-288020-vhtr3l0w 17 23 both both CC cord-288020-vhtr3l0w 17 24 the the DT cord-288020-vhtr3l0w 17 25 training training NN cord-288020-vhtr3l0w 17 26 and and CC cord-288020-vhtr3l0w 17 27 validation validation NN cord-288020-vhtr3l0w 17 28 cohorts cohort NNS cord-288020-vhtr3l0w 17 29 . . . cord-288020-vhtr3l0w 18 1 The the DT cord-288020-vhtr3l0w 18 2 main main JJ cord-288020-vhtr3l0w 18 3 strength strength NN cord-288020-vhtr3l0w 18 4 is be VBZ cord-288020-vhtr3l0w 18 5 the the DT cord-288020-vhtr3l0w 18 6 simplicity simplicity NN cord-288020-vhtr3l0w 18 7 of of IN cord-288020-vhtr3l0w 18 8 application application NN cord-288020-vhtr3l0w 18 9 in in IN cord-288020-vhtr3l0w 18 10 the the DT cord-288020-vhtr3l0w 18 11 clinical clinical JJ cord-288020-vhtr3l0w 18 12 setting setting NN cord-288020-vhtr3l0w 18 13 , , , cord-288020-vhtr3l0w 18 14 whereby whereby WRB cord-288020-vhtr3l0w 18 15 it -PRON- PRP cord-288020-vhtr3l0w 18 16 has have VBZ cord-288020-vhtr3l0w 18 17 the the DT cord-288020-vhtr3l0w 18 18 advantage advantage NN cord-288020-vhtr3l0w 18 19 of of IN cord-288020-vhtr3l0w 18 20 including include VBG cord-288020-vhtr3l0w 18 21 a a DT cord-288020-vhtr3l0w 18 22 small small JJ cord-288020-vhtr3l0w 18 23 number number NN cord-288020-vhtr3l0w 18 24 of of IN cord-288020-vhtr3l0w 18 25 parameters parameter NNS cord-288020-vhtr3l0w 18 26 that that WDT cord-288020-vhtr3l0w 18 27 are be VBP cord-288020-vhtr3l0w 18 28 easily easily RB cord-288020-vhtr3l0w 18 29 and and CC cord-288020-vhtr3l0w 18 30 routinely routinely RB cord-288020-vhtr3l0w 18 31 measured measure VBN cord-288020-vhtr3l0w 18 32 in in IN cord-288020-vhtr3l0w 18 33 hospitalized hospitalize VBN cord-288020-vhtr3l0w 18 34 patients patient NNS cord-288020-vhtr3l0w 18 35 with with IN cord-288020-vhtr3l0w 18 36 respiratory respiratory JJ cord-288020-vhtr3l0w 18 37 infections infection NNS cord-288020-vhtr3l0w 18 38 . . . cord-288020-vhtr3l0w 19 1 Furthermore furthermore RB cord-288020-vhtr3l0w 19 2 , , , cord-288020-vhtr3l0w 19 3 the the DT cord-288020-vhtr3l0w 19 4 HNC HNC NNP cord-288020-vhtr3l0w 19 5 - - HYPH cord-288020-vhtr3l0w 19 6 LL LL NNP cord-288020-vhtr3l0w 19 7 appears appear VBZ cord-288020-vhtr3l0w 19 8 to to TO cord-288020-vhtr3l0w 19 9 outperform outperform VB cord-288020-vhtr3l0w 19 10 comparable comparable JJ cord-288020-vhtr3l0w 19 11 scores score NNS cord-288020-vhtr3l0w 19 12 that that WDT cord-288020-vhtr3l0w 19 13 have have VBP cord-288020-vhtr3l0w 19 14 been be VBN cord-288020-vhtr3l0w 19 15 proposed propose VBN cord-288020-vhtr3l0w 19 16 during during IN cord-288020-vhtr3l0w 19 17 the the DT cord-288020-vhtr3l0w 19 18 COVID-19 COVID-19 NNP cord-288020-vhtr3l0w 19 19 pandemic pandemic NN cord-288020-vhtr3l0w 19 20 , , , cord-288020-vhtr3l0w 19 21 such such JJ cord-288020-vhtr3l0w 19 22 as as IN cord-288020-vhtr3l0w 19 23 the the DT cord-288020-vhtr3l0w 19 24 CURB-65 CURB-65 NNP cord-288020-vhtr3l0w 19 25 score score NN cord-288020-vhtr3l0w 19 26 ( ( -LRB- cord-288020-vhtr3l0w 19 27 confusion confusion NN cord-288020-vhtr3l0w 19 28 , , , cord-288020-vhtr3l0w 19 29 urea urea NN cord-288020-vhtr3l0w 19 30 , , , cord-288020-vhtr3l0w 19 31 respiratory respiratory JJ cord-288020-vhtr3l0w 19 32 rate rate NN cord-288020-vhtr3l0w 19 33 , , , cord-288020-vhtr3l0w 19 34 blood blood NN cord-288020-vhtr3l0w 19 35 pressure pressure NN cord-288020-vhtr3l0w 19 36 , , , cord-288020-vhtr3l0w 19 37 65 65 CD cord-288020-vhtr3l0w 19 38 years year NNS cord-288020-vhtr3l0w 19 39 ) ) -RRB- cord-288020-vhtr3l0w 19 40 , , , cord-288020-vhtr3l0w 19 41 the the DT cord-288020-vhtr3l0w 19 42 MuLBSTA MuLBSTA NNP cord-288020-vhtr3l0w 19 43 score score NN cord-288020-vhtr3l0w 19 44 ( ( -LRB- cord-288020-vhtr3l0w 19 45 multilobular multilobular JJ cord-288020-vhtr3l0w 19 46 infiltration infiltration NN cord-288020-vhtr3l0w 19 47 , , , cord-288020-vhtr3l0w 19 48 hypo hypo NN cord-288020-vhtr3l0w 19 49 - - HYPH cord-288020-vhtr3l0w 19 50 lymphocytosis lymphocytosis JJ cord-288020-vhtr3l0w 19 51 , , , cord-288020-vhtr3l0w 19 52 bacterial bacterial JJ cord-288020-vhtr3l0w 19 53 coinfection coinfection NN cord-288020-vhtr3l0w 19 54 , , , cord-288020-vhtr3l0w 19 55 smoking smoke VBG cord-288020-vhtr3l0w 19 56 history history NN cord-288020-vhtr3l0w 19 57 , , , cord-288020-vhtr3l0w 19 58 hypertension hypertension NN cord-288020-vhtr3l0w 19 59 , , , cord-288020-vhtr3l0w 19 60 and and CC cord-288020-vhtr3l0w 19 61 age age NN cord-288020-vhtr3l0w 19 62 ) ) -RRB- cord-288020-vhtr3l0w 19 63 and and CC cord-288020-vhtr3l0w 19 64 the the DT cord-288020-vhtr3l0w 19 65 neutrophil neutrophil NN cord-288020-vhtr3l0w 19 66 - - HYPH cord-288020-vhtr3l0w 19 67 to to IN cord-288020-vhtr3l0w 19 68 - - HYPH cord-288020-vhtr3l0w 19 69 lymphocyte lymphocyte NN cord-288020-vhtr3l0w 19 70 ratio ratio NN cord-288020-vhtr3l0w 19 71 . . . cord-288020-vhtr3l0w 20 1 Importantly importantly RB cord-288020-vhtr3l0w 20 2 , , , cord-288020-vhtr3l0w 20 3 the the DT cord-288020-vhtr3l0w 20 4 HNC HNC NNP cord-288020-vhtr3l0w 20 5 - - HYPH cord-288020-vhtr3l0w 20 6 LL LL NNP cord-288020-vhtr3l0w 20 7 score score NN cord-288020-vhtr3l0w 20 8 also also RB cord-288020-vhtr3l0w 20 9 had have VBD cord-288020-vhtr3l0w 20 10 a a DT cord-288020-vhtr3l0w 20 11 good good JJ cord-288020-vhtr3l0w 20 12 predictive predictive JJ cord-288020-vhtr3l0w 20 13 ability ability NN cord-288020-vhtr3l0w 20 14 to to TO cord-288020-vhtr3l0w 20 15 identify identify VB cord-288020-vhtr3l0w 20 16 those those DT cord-288020-vhtr3l0w 20 17 patients patient NNS cord-288020-vhtr3l0w 20 18 who who WP cord-288020-vhtr3l0w 20 19 were be VBD cord-288020-vhtr3l0w 20 20 admitted admit VBN cord-288020-vhtr3l0w 20 21 to to IN cord-288020-vhtr3l0w 20 22 hospital hospital NN cord-288020-vhtr3l0w 20 23 with with IN cord-288020-vhtr3l0w 20 24 mild mild JJ cord-288020-vhtr3l0w 20 25 disease disease NN cord-288020-vhtr3l0w 20 26 and and CC cord-288020-vhtr3l0w 20 27 progressed progress VBD cord-288020-vhtr3l0w 20 28 to to IN cord-288020-vhtr3l0w 20 29 a a DT cord-288020-vhtr3l0w 20 30 severe severe JJ cord-288020-vhtr3l0w 20 31 disease disease NN cord-288020-vhtr3l0w 20 32 during during IN cord-288020-vhtr3l0w 20 33 their -PRON- PRP$ cord-288020-vhtr3l0w 20 34 hospital hospital NN cord-288020-vhtr3l0w 20 35 stay stay NN cord-288020-vhtr3l0w 20 36 . . . cord-288020-vhtr3l0w 21 1 The the DT cord-288020-vhtr3l0w 21 2 timing timing NN cord-288020-vhtr3l0w 21 3 of of IN cord-288020-vhtr3l0w 21 4 the the DT cord-288020-vhtr3l0w 21 5 risk risk NN cord-288020-vhtr3l0w 21 6 stratification stratification NN cord-288020-vhtr3l0w 21 7 process process NN cord-288020-vhtr3l0w 21 8 in in IN cord-288020-vhtr3l0w 21 9 the the DT cord-288020-vhtr3l0w 21 10 course course NN cord-288020-vhtr3l0w 21 11 of of IN cord-288020-vhtr3l0w 21 12 the the DT cord-288020-vhtr3l0w 21 13 disease disease NN cord-288020-vhtr3l0w 21 14 for for IN cord-288020-vhtr3l0w 21 15 each each DT cord-288020-vhtr3l0w 21 16 individual individual JJ cord-288020-vhtr3l0w 21 17 patient patient NN cord-288020-vhtr3l0w 21 18 is be VBZ cord-288020-vhtr3l0w 21 19 critical critical JJ cord-288020-vhtr3l0w 21 20 . . . cord-288020-vhtr3l0w 22 1 In in IN cord-288020-vhtr3l0w 22 2 the the DT cord-288020-vhtr3l0w 22 3 present present JJ cord-288020-vhtr3l0w 22 4 study study NN cord-288020-vhtr3l0w 22 5 , , , cord-288020-vhtr3l0w 22 6 the the DT cord-288020-vhtr3l0w 22 7 blood blood NN cord-288020-vhtr3l0w 22 8 sampling sampling NN cord-288020-vhtr3l0w 22 9 and and CC cord-288020-vhtr3l0w 22 10 assessment assessment NN cord-288020-vhtr3l0w 22 11 of of IN cord-288020-vhtr3l0w 22 12 risk risk NN cord-288020-vhtr3l0w 22 13 factors factor NNS cord-288020-vhtr3l0w 22 14 used use VBN cord-288020-vhtr3l0w 22 15 to to TO cord-288020-vhtr3l0w 22 16 determine determine VB cord-288020-vhtr3l0w 22 17 the the DT cord-288020-vhtr3l0w 22 18 HNC HNC NNP cord-288020-vhtr3l0w 22 19 - - HYPH cord-288020-vhtr3l0w 22 20 LL LL NNP cord-288020-vhtr3l0w 22 21 risk risk NN cord-288020-vhtr3l0w 22 22 score score NN cord-288020-vhtr3l0w 22 23 were be VBD cord-288020-vhtr3l0w 22 24 performed perform VBN cord-288020-vhtr3l0w 22 25 on on IN cord-288020-vhtr3l0w 22 26 the the DT cord-288020-vhtr3l0w 22 27 day day NN cord-288020-vhtr3l0w 22 28 of of IN cord-288020-vhtr3l0w 22 29 hospital hospital NN cord-288020-vhtr3l0w 22 30 admission admission NN cord-288020-vhtr3l0w 22 31 . . . cord-288020-vhtr3l0w 23 1 However however RB cord-288020-vhtr3l0w 23 2 , , , cord-288020-vhtr3l0w 23 3 patients patient NNS cord-288020-vhtr3l0w 23 4 likely likely RB cord-288020-vhtr3l0w 23 5 presented present VBN cord-288020-vhtr3l0w 23 6 to to IN cord-288020-vhtr3l0w 23 7 the the DT cord-288020-vhtr3l0w 23 8 hospital hospital NN cord-288020-vhtr3l0w 23 9 at at IN cord-288020-vhtr3l0w 23 10 different different JJ cord-288020-vhtr3l0w 23 11 stages stage NNS cord-288020-vhtr3l0w 23 12 of of IN cord-288020-vhtr3l0w 23 13 their -PRON- PRP$ cord-288020-vhtr3l0w 23 14 disease disease NN cord-288020-vhtr3l0w 23 15 . . . cord-288020-vhtr3l0w 24 1 The the DT cord-288020-vhtr3l0w 24 2 delay delay NN cord-288020-vhtr3l0w 24 3 between between IN cord-288020-vhtr3l0w 24 4 the the DT cord-288020-vhtr3l0w 24 5 onset onset NN cord-288020-vhtr3l0w 24 6 of of IN cord-288020-vhtr3l0w 24 7 symptoms symptom NNS cord-288020-vhtr3l0w 24 8 and and CC cord-288020-vhtr3l0w 24 9 the the DT cord-288020-vhtr3l0w 24 10 medical medical JJ cord-288020-vhtr3l0w 24 11 examination examination NN cord-288020-vhtr3l0w 24 12 is be VBZ cord-288020-vhtr3l0w 24 13 a a DT cord-288020-vhtr3l0w 24 14 key key JJ cord-288020-vhtr3l0w 24 15 factor factor NN cord-288020-vhtr3l0w 24 16 to to TO cord-288020-vhtr3l0w 24 17 consider consider VB cord-288020-vhtr3l0w 24 18 as as IN cord-288020-vhtr3l0w 24 19 it -PRON- PRP cord-288020-vhtr3l0w 24 20 provides provide VBZ cord-288020-vhtr3l0w 24 21 an an DT cord-288020-vhtr3l0w 24 22 estimation estimation NN cord-288020-vhtr3l0w 24 23 of of IN cord-288020-vhtr3l0w 24 24 the the DT cord-288020-vhtr3l0w 24 25 stage stage NN cord-288020-vhtr3l0w 24 26 of of IN cord-288020-vhtr3l0w 24 27 disease disease NN cord-288020-vhtr3l0w 24 28 , , , cord-288020-vhtr3l0w 24 29 which which WDT cord-288020-vhtr3l0w 24 30 was be VBD cord-288020-vhtr3l0w 24 31 not not RB cord-288020-vhtr3l0w 24 32 taken take VBN cord-288020-vhtr3l0w 24 33 into into IN cord-288020-vhtr3l0w 24 34 account account NN cord-288020-vhtr3l0w 24 35 in in IN cord-288020-vhtr3l0w 24 36 the the DT cord-288020-vhtr3l0w 24 37 study study NN cord-288020-vhtr3l0w 24 38 by by IN cord-288020-vhtr3l0w 24 39 Xiao Xiao NNP cord-288020-vhtr3l0w 24 40 et et NNP cord-288020-vhtr3l0w 24 41 al al NNP cord-288020-vhtr3l0w 24 42 . . . cord-288020-vhtr3l0w 25 1 [ [ -LRB- cord-288020-vhtr3l0w 25 2 1 1 CD cord-288020-vhtr3l0w 25 3 ] ] -RRB- cord-288020-vhtr3l0w 26 1 Another another DT cord-288020-vhtr3l0w 26 2 limitation limitation NN cord-288020-vhtr3l0w 26 3 of of IN cord-288020-vhtr3l0w 26 4 the the DT cord-288020-vhtr3l0w 26 5 HNC HNC NNP cord-288020-vhtr3l0w 26 6 - - HYPH cord-288020-vhtr3l0w 26 7 LL LL NNP cord-288020-vhtr3l0w 26 8 , , , cord-288020-vhtr3l0w 26 9 CURB-65 CURB-65 NNP cord-288020-vhtr3l0w 26 10 or or CC cord-288020-vhtr3l0w 26 11 MuLBSTA MuLBSTA NNP cord-288020-vhtr3l0w 26 12 scores score NNS cord-288020-vhtr3l0w 26 13 is be VBZ cord-288020-vhtr3l0w 26 14 that that IN cord-288020-vhtr3l0w 26 15 they -PRON- PRP cord-288020-vhtr3l0w 26 16 require require VBP cord-288020-vhtr3l0w 26 17 blood blood NN cord-288020-vhtr3l0w 26 18 sampling sampling NN cord-288020-vhtr3l0w 26 19 [ [ -LRB- cord-288020-vhtr3l0w 26 20 2 2 CD cord-288020-vhtr3l0w 26 21 , , , cord-288020-vhtr3l0w 26 22 3 3 CD cord-288020-vhtr3l0w 26 23 ] ] -RRB- cord-288020-vhtr3l0w 26 24 , , , cord-288020-vhtr3l0w 26 25 which which WDT cord-288020-vhtr3l0w 26 26 limit limit VBP cord-288020-vhtr3l0w 26 27 their -PRON- PRP$ cord-288020-vhtr3l0w 26 28 utilisation utilisation NN cord-288020-vhtr3l0w 26 29 for for IN cord-288020-vhtr3l0w 26 30 non non JJ cord-288020-vhtr3l0w 26 31 - - JJ cord-288020-vhtr3l0w 26 32 hospitalized hospitalize VBN cord-288020-vhtr3l0w 26 33 patients patient NNS cord-288020-vhtr3l0w 26 34 with with IN cord-288020-vhtr3l0w 26 35 mild mild JJ cord-288020-vhtr3l0w 26 36 or or CC cord-288020-vhtr3l0w 26 37 moderate moderate JJ cord-288020-vhtr3l0w 26 38 symptoms symptom NNS cord-288020-vhtr3l0w 26 39 . . . cord-288020-vhtr3l0w 27 1 A a DT cord-288020-vhtr3l0w 27 2 recent recent JJ cord-288020-vhtr3l0w 27 3 study study NN cord-288020-vhtr3l0w 27 4 reported report VBD cord-288020-vhtr3l0w 27 5 that that IN cord-288020-vhtr3l0w 27 6 21 21 CD cord-288020-vhtr3l0w 27 7 % % NN cord-288020-vhtr3l0w 27 8 of of IN cord-288020-vhtr3l0w 27 9 COVID-19 covid-19 JJ cord-288020-vhtr3l0w 27 10 patients patient NNS cord-288020-vhtr3l0w 27 11 initially initially RB cord-288020-vhtr3l0w 27 12 considered consider VBN cord-288020-vhtr3l0w 27 13 to to TO cord-288020-vhtr3l0w 27 14 be be VB cord-288020-vhtr3l0w 27 15 at at IN cord-288020-vhtr3l0w 27 16 low low JJ cord-288020-vhtr3l0w 27 17 risk risk NN cord-288020-vhtr3l0w 27 18 , , , cord-288020-vhtr3l0w 27 19 in in IN cord-288020-vhtr3l0w 27 20 fact fact NN cord-288020-vhtr3l0w 27 21 , , , cord-288020-vhtr3l0w 27 22 had have VBD cord-288020-vhtr3l0w 27 23 poor poor JJ cord-288020-vhtr3l0w 27 24 outcomes outcome NNS cord-288020-vhtr3l0w 27 25 [ [ -LRB- cord-288020-vhtr3l0w 27 26 4 4 CD cord-288020-vhtr3l0w 27 27 ] ] -RRB- cord-288020-vhtr3l0w 27 28 . . . cord-288020-vhtr3l0w 28 1 One one CD cord-288020-vhtr3l0w 28 2 potential potential JJ cord-288020-vhtr3l0w 28 3 solution solution NN cord-288020-vhtr3l0w 28 4 to to TO cord-288020-vhtr3l0w 28 5 optimize optimize VB cord-288020-vhtr3l0w 28 6 the the DT cord-288020-vhtr3l0w 28 7 risk risk NN cord-288020-vhtr3l0w 28 8 stratification stratification NN cord-288020-vhtr3l0w 28 9 process process NN cord-288020-vhtr3l0w 28 10 would would MD cord-288020-vhtr3l0w 28 11 be be VB cord-288020-vhtr3l0w 28 12 to to TO cord-288020-vhtr3l0w 28 13 use use VB cord-288020-vhtr3l0w 28 14 different different JJ cord-288020-vhtr3l0w 28 15 scores score NNS cord-288020-vhtr3l0w 28 16 adapted adapt VBN cord-288020-vhtr3l0w 28 17 to to IN cord-288020-vhtr3l0w 28 18 the the DT cord-288020-vhtr3l0w 28 19 setting setting NN cord-288020-vhtr3l0w 28 20 and and CC cord-288020-vhtr3l0w 28 21 the the DT cord-288020-vhtr3l0w 28 22 timing timing NN cord-288020-vhtr3l0w 28 23 of of IN cord-288020-vhtr3l0w 28 24 the the DT cord-288020-vhtr3l0w 28 25 patient patient JJ cord-288020-vhtr3l0w 28 26 presentation presentation NN cord-288020-vhtr3l0w 28 27 . . . cord-288020-vhtr3l0w 29 1 Hence hence RB cord-288020-vhtr3l0w 29 2 , , , cord-288020-vhtr3l0w 29 3 in in IN cord-288020-vhtr3l0w 29 4 an an DT cord-288020-vhtr3l0w 29 5 outpatient outpatient NN cord-288020-vhtr3l0w 29 6 setting setting NN cord-288020-vhtr3l0w 29 7 , , , cord-288020-vhtr3l0w 29 8 where where WRB cord-288020-vhtr3l0w 29 9 patients patient NNS cord-288020-vhtr3l0w 29 10 would would MD cord-288020-vhtr3l0w 29 11 generally generally RB cord-288020-vhtr3l0w 29 12 be be VB cord-288020-vhtr3l0w 29 13 at at IN cord-288020-vhtr3l0w 29 14 an an DT cord-288020-vhtr3l0w 29 15 earlier early JJR cord-288020-vhtr3l0w 29 16 stage stage NN cord-288020-vhtr3l0w 29 17 of of IN cord-288020-vhtr3l0w 29 18 the the DT cord-288020-vhtr3l0w 29 19 disease disease NN cord-288020-vhtr3l0w 29 20 , , , cord-288020-vhtr3l0w 29 21 clinical clinical JJ cord-288020-vhtr3l0w 29 22 scores score NNS cord-288020-vhtr3l0w 29 23 such such JJ cord-288020-vhtr3l0w 29 24 as as IN cord-288020-vhtr3l0w 29 25 the the DT cord-288020-vhtr3l0w 29 26 CRB-65 CRB-65 NNP cord-288020-vhtr3l0w 29 27 ( ( -LRB- cord-288020-vhtr3l0w 29 28 CURB-65 curb-65 NN cord-288020-vhtr3l0w 29 29 without without IN cord-288020-vhtr3l0w 29 30 urea urea NN cord-288020-vhtr3l0w 29 31 ) ) -RRB- cord-288020-vhtr3l0w 29 32 or or CC cord-288020-vhtr3l0w 29 33 the the DT cord-288020-vhtr3l0w 29 34 qSOFA qsofa JJ cord-288020-vhtr3l0w 29 35 score score NN cord-288020-vhtr3l0w 29 36 ( ( -LRB- cord-288020-vhtr3l0w 29 37 quick quick JJ cord-288020-vhtr3l0w 29 38 sepsis sepsis NN cord-288020-vhtr3l0w 29 39 - - HYPH cord-288020-vhtr3l0w 29 40 related relate VBN cord-288020-vhtr3l0w 29 41 organ organ NN cord-288020-vhtr3l0w 29 42 failure failure NN cord-288020-vhtr3l0w 29 43 assessment assessment NN cord-288020-vhtr3l0w 29 44 ) ) -RRB- cord-288020-vhtr3l0w 29 45 could could MD cord-288020-vhtr3l0w 29 46 be be VB cord-288020-vhtr3l0w 29 47 considered consider VBN cord-288020-vhtr3l0w 29 48 [ [ -LRB- cord-288020-vhtr3l0w 29 49 5 5 CD cord-288020-vhtr3l0w 29 50 ] ] -RRB- cord-288020-vhtr3l0w 29 51 . . . cord-288020-vhtr3l0w 30 1 Given give VBN cord-288020-vhtr3l0w 30 2 that that IN cord-288020-vhtr3l0w 30 3 these these DT cord-288020-vhtr3l0w 30 4 scores score NNS cord-288020-vhtr3l0w 30 5 are be VBP cord-288020-vhtr3l0w 30 6 usually usually RB cord-288020-vhtr3l0w 30 7 utilized utilize VBN cord-288020-vhtr3l0w 30 8 in in IN cord-288020-vhtr3l0w 30 9 the the DT cord-288020-vhtr3l0w 30 10 context context NN cord-288020-vhtr3l0w 30 11 of of IN cord-288020-vhtr3l0w 30 12 severe severe JJ cord-288020-vhtr3l0w 30 13 disease disease NN cord-288020-vhtr3l0w 30 14 , , , cord-288020-vhtr3l0w 30 15 lower lower RBR cord-288020-vhtr3l0w 30 16 cut cut VB cord-288020-vhtr3l0w 30 17 - - HYPH cord-288020-vhtr3l0w 30 18 off off RP cord-288020-vhtr3l0w 30 19 values value NNS cord-288020-vhtr3l0w 30 20 should should MD cord-288020-vhtr3l0w 30 21 likely likely RB cord-288020-vhtr3l0w 30 22 be be VB cord-288020-vhtr3l0w 30 23 applied apply VBN cord-288020-vhtr3l0w 30 24 to to TO cord-288020-vhtr3l0w 30 25 improve improve VB cord-288020-vhtr3l0w 30 26 their -PRON- PRP$ cord-288020-vhtr3l0w 30 27 sensitivity sensitivity NN cord-288020-vhtr3l0w 30 28 to to TO cord-288020-vhtr3l0w 30 29 identify identify VB cord-288020-vhtr3l0w 30 30 the the DT cord-288020-vhtr3l0w 30 31 patients patient NNS cord-288020-vhtr3l0w 30 32 being be VBG cord-288020-vhtr3l0w 30 33 at at IN cord-288020-vhtr3l0w 30 34 risk risk NN cord-288020-vhtr3l0w 30 35 of of IN cord-288020-vhtr3l0w 30 36 hospitalization hospitalization NN cord-288020-vhtr3l0w 30 37 and and CC cord-288020-vhtr3l0w 30 38 complications complication NNS cord-288020-vhtr3l0w 30 39 ( ( -LRB- cord-288020-vhtr3l0w 30 40 Fig fig NN cord-288020-vhtr3l0w 30 41 . . NNP cord-288020-vhtr3l0w 30 42 1 1 CD cord-288020-vhtr3l0w 30 43 ) ) -RRB- cord-288020-vhtr3l0w 30 44 . . . cord-288020-vhtr3l0w 31 1 Another another DT cord-288020-vhtr3l0w 31 2 way way NN cord-288020-vhtr3l0w 31 3 to to TO cord-288020-vhtr3l0w 31 4 potentially potentially RB cord-288020-vhtr3l0w 31 5 improve improve VB cord-288020-vhtr3l0w 31 6 the the DT cord-288020-vhtr3l0w 31 7 performance performance NN cord-288020-vhtr3l0w 31 8 of of IN cord-288020-vhtr3l0w 31 9 those those DT cord-288020-vhtr3l0w 31 10 risk risk NN cord-288020-vhtr3l0w 31 11 scores score NNS cord-288020-vhtr3l0w 31 12 in in IN cord-288020-vhtr3l0w 31 13 the the DT cord-288020-vhtr3l0w 31 14 management management NN cord-288020-vhtr3l0w 31 15 of of IN cord-288020-vhtr3l0w 31 16 COVD-19 COVD-19 NNP cord-288020-vhtr3l0w 31 17 would would MD cord-288020-vhtr3l0w 31 18 be be VB cord-288020-vhtr3l0w 31 19 to to TO cord-288020-vhtr3l0w 31 20 include include VB cord-288020-vhtr3l0w 31 21 clinical clinical JJ cord-288020-vhtr3l0w 31 22 factors factor NNS cord-288020-vhtr3l0w 31 23 proven prove VBN cord-288020-vhtr3l0w 31 24 relevant relevant JJ cord-288020-vhtr3l0w 31 25 to to IN cord-288020-vhtr3l0w 31 26 affected affected JJ cord-288020-vhtr3l0w 31 27 patients patient NNS cord-288020-vhtr3l0w 31 28 ( ( -LRB- cord-288020-vhtr3l0w 31 29 Fig Fig NNP cord-288020-vhtr3l0w 31 30 . . . cord-288020-vhtr3l0w 31 31 1 1 CD cord-288020-vhtr3l0w 31 32 ) ) -RRB- cord-288020-vhtr3l0w 31 33 . . . cord-288020-vhtr3l0w 32 1 Indeed indeed RB cord-288020-vhtr3l0w 32 2 , , , cord-288020-vhtr3l0w 32 3 a a DT cord-288020-vhtr3l0w 32 4 striking striking JJ cord-288020-vhtr3l0w 32 5 difference difference NN cord-288020-vhtr3l0w 32 6 of of IN cord-288020-vhtr3l0w 32 7 SARS SARS NNP cord-288020-vhtr3l0w 32 8 - - HYPH cord-288020-vhtr3l0w 32 9 COV-2 COV-2 NNP cord-288020-vhtr3l0w 32 10 infection infection NN cord-288020-vhtr3l0w 32 11 compared compare VBN cord-288020-vhtr3l0w 32 12 to to IN cord-288020-vhtr3l0w 32 13 other other JJ cord-288020-vhtr3l0w 32 14 respiratory respiratory JJ cord-288020-vhtr3l0w 32 15 viral viral JJ cord-288020-vhtr3l0w 32 16 infections infection NNS cord-288020-vhtr3l0w 32 17 is be VBZ cord-288020-vhtr3l0w 32 18 that that IN cord-288020-vhtr3l0w 32 19 cardiometabolic cardiometabolic JJ cord-288020-vhtr3l0w 32 20 comorbidities comorbiditie NNS cord-288020-vhtr3l0w 32 21 have have VBP cord-288020-vhtr3l0w 32 22 been be VBN cord-288020-vhtr3l0w 32 23 over over RB cord-288020-vhtr3l0w 32 24 - - HYPH cord-288020-vhtr3l0w 32 25 represented represent VBN cord-288020-vhtr3l0w 32 26 in in IN cord-288020-vhtr3l0w 32 27 patients patient NNS cord-288020-vhtr3l0w 32 28 presenting present VBG cord-288020-vhtr3l0w 32 29 complications complication NNS cord-288020-vhtr3l0w 32 30 , , , cord-288020-vhtr3l0w 32 31 while while IN cord-288020-vhtr3l0w 32 32 other other JJ cord-288020-vhtr3l0w 32 33 pulmonary pulmonary JJ cord-288020-vhtr3l0w 32 34 comorbidities comorbiditie NNS cord-288020-vhtr3l0w 32 35 that that WDT cord-288020-vhtr3l0w 32 36 are be VBP cord-288020-vhtr3l0w 32 37 usually usually RB cord-288020-vhtr3l0w 32 38 more more RBR cord-288020-vhtr3l0w 32 39 prevalent prevalent JJ cord-288020-vhtr3l0w 32 40 with with IN cord-288020-vhtr3l0w 32 41 respiratory respiratory JJ cord-288020-vhtr3l0w 32 42 viral viral JJ cord-288020-vhtr3l0w 32 43 infections infection NNS cord-288020-vhtr3l0w 32 44 such such JJ cord-288020-vhtr3l0w 32 45 as as IN cord-288020-vhtr3l0w 32 46 asthma asthma NN cord-288020-vhtr3l0w 32 47 , , , cord-288020-vhtr3l0w 32 48 smoking smoking NN cord-288020-vhtr3l0w 32 49 , , , cord-288020-vhtr3l0w 32 50 or or CC cord-288020-vhtr3l0w 32 51 COPD COPD NNP cord-288020-vhtr3l0w 32 52 are be VBP cord-288020-vhtr3l0w 32 53 under under RB cord-288020-vhtr3l0w 32 54 - - HYPH cord-288020-vhtr3l0w 32 55 represented represent VBN cord-288020-vhtr3l0w 32 56 . . . cord-288020-vhtr3l0w 33 1 In in IN cord-288020-vhtr3l0w 33 2 the the DT cord-288020-vhtr3l0w 33 3 study study NN cord-288020-vhtr3l0w 33 4 of of IN cord-288020-vhtr3l0w 33 5 Xiao Xiao NNP cord-288020-vhtr3l0w 33 6 et et NNP cord-288020-vhtr3l0w 33 7 al al NNP cord-288020-vhtr3l0w 33 8 . . . cord-288020-vhtr3l0w 34 1 hypertension hypertension NN cord-288020-vhtr3l0w 34 2 was be VBD cord-288020-vhtr3l0w 34 3 included include VBN cord-288020-vhtr3l0w 34 4 into into IN cord-288020-vhtr3l0w 34 5 the the DT cord-288020-vhtr3l0w 34 6 risk risk NN cord-288020-vhtr3l0w 34 7 score score NN cord-288020-vhtr3l0w 34 8 but but CC cord-288020-vhtr3l0w 34 9 not not RB cord-288020-vhtr3l0w 34 10 obesity obesity NN cord-288020-vhtr3l0w 34 11 or or CC cord-288020-vhtr3l0w 34 12 diabetes diabetes NN cord-288020-vhtr3l0w 34 13 [ [ -LRB- cord-288020-vhtr3l0w 34 14 1 1 CD cord-288020-vhtr3l0w 34 15 ] ] -RRB- cord-288020-vhtr3l0w 34 16 , , , cord-288020-vhtr3l0w 34 17 which which WDT cord-288020-vhtr3l0w 34 18 have have VBP cord-288020-vhtr3l0w 34 19 previously previously RB cord-288020-vhtr3l0w 34 20 been be VBN cord-288020-vhtr3l0w 34 21 shown show VBN cord-288020-vhtr3l0w 34 22 to to TO cord-288020-vhtr3l0w 34 23 be be VB cord-288020-vhtr3l0w 34 24 strongly strongly RB cord-288020-vhtr3l0w 34 25 associated associate VBN cord-288020-vhtr3l0w 34 26 with with IN cord-288020-vhtr3l0w 34 27 poor poor JJ cord-288020-vhtr3l0w 34 28 outcomes outcome NNS cord-288020-vhtr3l0w 34 29 in in IN cord-288020-vhtr3l0w 34 30 patients patient NNS cord-288020-vhtr3l0w 34 31 with with IN cord-288020-vhtr3l0w 34 32 COVID-19 COVID-19 NNP cord-288020-vhtr3l0w 34 33 [ [ -LRB- cord-288020-vhtr3l0w 34 34 6 6 CD cord-288020-vhtr3l0w 34 35 ] ] -RRB- cord-288020-vhtr3l0w 34 36 . . . cord-288020-vhtr3l0w 35 1 The the DT cord-288020-vhtr3l0w 35 2 set set NN cord-288020-vhtr3l0w 35 3 of of IN cord-288020-vhtr3l0w 35 4 variables variable NNS cord-288020-vhtr3l0w 35 5 included include VBN cord-288020-vhtr3l0w 35 6 in in IN cord-288020-vhtr3l0w 35 7 the the DT cord-288020-vhtr3l0w 35 8 final final JJ cord-288020-vhtr3l0w 35 9 score score NN cord-288020-vhtr3l0w 35 10 by by IN cord-288020-vhtr3l0w 35 11 Xiao Xiao NNP cord-288020-vhtr3l0w 35 12 et et NNP cord-288020-vhtr3l0w 35 13 al al NNP cord-288020-vhtr3l0w 35 14 . . NNP cord-288020-vhtr3l0w 35 15 presents present VBZ cord-288020-vhtr3l0w 35 16 several several JJ cord-288020-vhtr3l0w 35 17 limitations limitation NNS cord-288020-vhtr3l0w 35 18 and and CC cord-288020-vhtr3l0w 35 19 pitfalls pitfall NNS cord-288020-vhtr3l0w 35 20 that that WDT cord-288020-vhtr3l0w 35 21 warrant warrant VBP cord-288020-vhtr3l0w 35 22 discussion discussion NN cord-288020-vhtr3l0w 35 23 . . . cord-288020-vhtr3l0w 36 1 First first RB cord-288020-vhtr3l0w 36 2 , , , cord-288020-vhtr3l0w 36 3 the the DT cord-288020-vhtr3l0w 36 4 authors author NNS cord-288020-vhtr3l0w 36 5 included include VBD cord-288020-vhtr3l0w 36 6 two two CD cord-288020-vhtr3l0w 36 7 markers marker NNS cord-288020-vhtr3l0w 36 8 of of IN cord-288020-vhtr3l0w 36 9 white white JJ cord-288020-vhtr3l0w 36 10 blood blood NN cord-288020-vhtr3l0w 36 11 cells cell NNS cord-288020-vhtr3l0w 36 12 , , , cord-288020-vhtr3l0w 36 13 which which WDT cord-288020-vhtr3l0w 36 14 may may MD cord-288020-vhtr3l0w 36 15 , , , cord-288020-vhtr3l0w 36 16 to to IN cord-288020-vhtr3l0w 36 17 some some DT cord-288020-vhtr3l0w 36 18 extent extent NN cord-288020-vhtr3l0w 36 19 be be VB cord-288020-vhtr3l0w 36 20 redundant redundant JJ cord-288020-vhtr3l0w 36 21 . . . cord-288020-vhtr3l0w 37 1 It -PRON- PRP cord-288020-vhtr3l0w 37 2 also also RB cord-288020-vhtr3l0w 37 3 likely likely RB cord-288020-vhtr3l0w 37 4 suggests suggest VBZ cord-288020-vhtr3l0w 37 5 that that IN cord-288020-vhtr3l0w 37 6 patients patient NNS cord-288020-vhtr3l0w 37 7 had have VBD cord-288020-vhtr3l0w 37 8 been be VBN cord-288020-vhtr3l0w 37 9 infected infect VBN cord-288020-vhtr3l0w 37 10 for for IN cord-288020-vhtr3l0w 37 11 several several JJ cord-288020-vhtr3l0w 37 12 days day NNS cord-288020-vhtr3l0w 37 13 and and CC cord-288020-vhtr3l0w 37 14 had have VBD cord-288020-vhtr3l0w 37 15 developed develop VBN cord-288020-vhtr3l0w 37 16 a a DT cord-288020-vhtr3l0w 37 17 bacterial bacterial JJ cord-288020-vhtr3l0w 37 18 infection infection NN cord-288020-vhtr3l0w 37 19 rendering render VBG cord-288020-vhtr3l0w 37 20 the the DT cord-288020-vhtr3l0w 37 21 neutrophil neutrophil NN cord-288020-vhtr3l0w 37 22 count count NN cord-288020-vhtr3l0w 37 23 significant significant JJ cord-288020-vhtr3l0w 37 24 . . . cord-288020-vhtr3l0w 38 1 The the DT cord-288020-vhtr3l0w 38 2 complications complication NNS cord-288020-vhtr3l0w 38 3 and and CC cord-288020-vhtr3l0w 38 4 adverse adverse JJ cord-288020-vhtr3l0w 38 5 events event NNS cord-288020-vhtr3l0w 38 6 associated associate VBN cord-288020-vhtr3l0w 38 7 with with IN cord-288020-vhtr3l0w 38 8 COVID-19 COVID-19 NNP cord-288020-vhtr3l0w 38 9 are be VBP cord-288020-vhtr3l0w 38 10 _SP cord-288020-vhtr3l0w 38 11 EBioMedicine EBioMedicine NNP cord-288020-vhtr3l0w 38 12 journal journal NN cord-288020-vhtr3l0w 38 13 homepage homepage NN cord-288020-vhtr3l0w 38 14 : : : cord-288020-vhtr3l0w 38 15 www.elsevier.com/locate/ebiom www.elsevier.com/locate/ebiom NNP cord-288020-vhtr3l0w 38 16 generally generally RB cord-288020-vhtr3l0w 38 17 related relate VBN cord-288020-vhtr3l0w 38 18 to to IN cord-288020-vhtr3l0w 38 19 inflammation inflammation NN cord-288020-vhtr3l0w 38 20 and and CC cord-288020-vhtr3l0w 38 21 the the DT cord-288020-vhtr3l0w 38 22 ensuing ensue VBG cord-288020-vhtr3l0w 38 23 " " `` cord-288020-vhtr3l0w 38 24 cytokine cytokine NN cord-288020-vhtr3l0w 38 25 storm storm NN cord-288020-vhtr3l0w 38 26 " " '' cord-288020-vhtr3l0w 38 27 , , , cord-288020-vhtr3l0w 38 28 thromboembolism thromboembolism NN cord-288020-vhtr3l0w 38 29 , , , cord-288020-vhtr3l0w 38 30 and and CC cord-288020-vhtr3l0w 38 31 cardiac cardiac JJ cord-288020-vhtr3l0w 38 32 damage damage NN cord-288020-vhtr3l0w 38 33 . . . cord-288020-vhtr3l0w 39 1 Previous previous JJ cord-288020-vhtr3l0w 39 2 studies study NNS cord-288020-vhtr3l0w 39 3 have have VBP cord-288020-vhtr3l0w 39 4 reported report VBN cord-288020-vhtr3l0w 39 5 that that IN cord-288020-vhtr3l0w 39 6 an an DT cord-288020-vhtr3l0w 39 7 important important JJ cord-288020-vhtr3l0w 39 8 proportion proportion NN cord-288020-vhtr3l0w 39 9 ( ( -LRB- cord-288020-vhtr3l0w 39 10 > > NFP cord-288020-vhtr3l0w 39 11 20 20 CD cord-288020-vhtr3l0w 39 12 % % NN cord-288020-vhtr3l0w 39 13 ) ) -RRB- cord-288020-vhtr3l0w 39 14 of of IN cord-288020-vhtr3l0w 39 15 hospitalized hospitalize VBN cord-288020-vhtr3l0w 39 16 patients patient NNS cord-288020-vhtr3l0w 39 17 with with IN cord-288020-vhtr3l0w 39 18 COVID-19 covid-19 DT cord-288020-vhtr3l0w 39 19 present present JJ cord-288020-vhtr3l0w 39 20 with with IN cord-288020-vhtr3l0w 39 21 a a DT cord-288020-vhtr3l0w 39 22 marked marked JJ cord-288020-vhtr3l0w 39 23 elevation elevation NN cord-288020-vhtr3l0w 39 24 of of IN cord-288020-vhtr3l0w 39 25 circulating circulate VBG cord-288020-vhtr3l0w 39 26 biomarkers biomarker NNS cord-288020-vhtr3l0w 39 27 of of IN cord-288020-vhtr3l0w 39 28 inflammation inflammation NN cord-288020-vhtr3l0w 39 29 ( ( -LRB- cord-288020-vhtr3l0w 39 30 CRP CRP NNP cord-288020-vhtr3l0w 39 31 , , , cord-288020-vhtr3l0w 39 32 Ferritin Ferritin NNP cord-288020-vhtr3l0w 39 33 ) ) -RRB- cord-288020-vhtr3l0w 39 34 , , , cord-288020-vhtr3l0w 39 35 cardiovascular cardiovascular JJ cord-288020-vhtr3l0w 39 36 damage damage NN cord-288020-vhtr3l0w 39 37 ( ( -LRB- cord-288020-vhtr3l0w 39 38 Troponin Troponin NNP cord-288020-vhtr3l0w 39 39 ) ) -RRB- cord-288020-vhtr3l0w 39 40 and and CC cord-288020-vhtr3l0w 39 41 thrombo thrombo NN cord-288020-vhtr3l0w 39 42 - - HYPH cord-288020-vhtr3l0w 39 43 embolism embolism NN cord-288020-vhtr3l0w 39 44 ( ( -LRB- cord-288020-vhtr3l0w 39 45 D D NNP cord-288020-vhtr3l0w 39 46 - - HYPH cord-288020-vhtr3l0w 39 47 Dimers Dimers NNPS cord-288020-vhtr3l0w 39 48 ) ) -RRB- cord-288020-vhtr3l0w 39 49 , , , cord-288020-vhtr3l0w 39 50 identifying identify VBG cord-288020-vhtr3l0w 39 51 subgroups subgroup NNS cord-288020-vhtr3l0w 39 52 of of IN cord-288020-vhtr3l0w 39 53 patients patient NNS cord-288020-vhtr3l0w 39 54 at at IN cord-288020-vhtr3l0w 39 55 high high JJ cord-288020-vhtr3l0w 39 56 risk risk NN cord-288020-vhtr3l0w 39 57 of of IN cord-288020-vhtr3l0w 39 58 in in IN cord-288020-vhtr3l0w 39 59 - - HYPH cord-288020-vhtr3l0w 39 60 hospital hospital NN cord-288020-vhtr3l0w 39 61 morbidity morbidity NN cord-288020-vhtr3l0w 39 62 and and CC cord-288020-vhtr3l0w 39 63 mortality mortality NN cord-288020-vhtr3l0w 39 64 [ [ -LRB- cord-288020-vhtr3l0w 39 65 7 7 CD cord-288020-vhtr3l0w 39 66 ] ] -RRB- cord-288020-vhtr3l0w 39 67 [ [ -LRB- cord-288020-vhtr3l0w 39 68 8 8 CD cord-288020-vhtr3l0w 39 69 ] ] -RRB- cord-288020-vhtr3l0w 39 70 [ [ -LRB- cord-288020-vhtr3l0w 39 71 9 9 CD cord-288020-vhtr3l0w 39 72 ] ] -RRB- cord-288020-vhtr3l0w 39 73 . . . cord-288020-vhtr3l0w 40 1 The the DT cord-288020-vhtr3l0w 40 2 authors author NNS cord-288020-vhtr3l0w 40 3 included include VBD cord-288020-vhtr3l0w 40 4 CRP CRP NNP cord-288020-vhtr3l0w 40 5 , , , cord-288020-vhtr3l0w 40 6 but but CC cord-288020-vhtr3l0w 40 7 did do VBD cord-288020-vhtr3l0w 40 8 not not RB cord-288020-vhtr3l0w 40 9 include include VB cord-288020-vhtr3l0w 40 10 other other JJ cord-288020-vhtr3l0w 40 11 potentially potentially RB cord-288020-vhtr3l0w 40 12 valuable valuable JJ cord-288020-vhtr3l0w 40 13 blood blood NN cord-288020-vhtr3l0w 40 14 biomarkers biomarker NNS cord-288020-vhtr3l0w 40 15 , , , cord-288020-vhtr3l0w 40 16 such such JJ cord-288020-vhtr3l0w 40 17 as as IN cord-288020-vhtr3l0w 40 18 D D NNP cord-288020-vhtr3l0w 40 19 - - HYPH cord-288020-vhtr3l0w 40 20 Dimers Dimers NNPS cord-288020-vhtr3l0w 40 21 , , , cord-288020-vhtr3l0w 40 22 Troponin Troponin NNP cord-288020-vhtr3l0w 40 23 and and CC cord-288020-vhtr3l0w 40 24 Ferritin ferritin NN cord-288020-vhtr3l0w 40 25 . . . cord-288020-vhtr3l0w 41 1 The the DT cord-288020-vhtr3l0w 41 2 proportion proportion NN cord-288020-vhtr3l0w 41 3 of of IN cord-288020-vhtr3l0w 41 4 these these DT cord-288020-vhtr3l0w 41 5 high high JJ cord-288020-vhtr3l0w 41 6 - - HYPH cord-288020-vhtr3l0w 41 7 risk risk NN cord-288020-vhtr3l0w 41 8 patients patient NNS cord-288020-vhtr3l0w 41 9 is be VBZ cord-288020-vhtr3l0w 41 10 relatively relatively RB cord-288020-vhtr3l0w 41 11 small small JJ cord-288020-vhtr3l0w 41 12 but but CC cord-288020-vhtr3l0w 41 13 there there EX cord-288020-vhtr3l0w 41 14 is be VBZ cord-288020-vhtr3l0w 41 15 , , , cord-288020-vhtr3l0w 41 16 nonetheless nonetheless RB cord-288020-vhtr3l0w 41 17 , , , cord-288020-vhtr3l0w 41 18 a a DT cord-288020-vhtr3l0w 41 19 need need NN cord-288020-vhtr3l0w 41 20 to to TO cord-288020-vhtr3l0w 41 21 identify identify VB cord-288020-vhtr3l0w 41 22 them -PRON- PRP cord-288020-vhtr3l0w 41 23 early early RB cord-288020-vhtr3l0w 41 24 in in IN cord-288020-vhtr3l0w 41 25 the the DT cord-288020-vhtr3l0w 41 26 course course NN cord-288020-vhtr3l0w 41 27 of of IN cord-288020-vhtr3l0w 41 28 the the DT cord-288020-vhtr3l0w 41 29 disease disease NN cord-288020-vhtr3l0w 41 30 to to TO cord-288020-vhtr3l0w 41 31 enable enable VB cord-288020-vhtr3l0w 41 32 timely timely JJ cord-288020-vhtr3l0w 41 33 and and CC cord-288020-vhtr3l0w 41 34 individualized individualized JJ cord-288020-vhtr3l0w 41 35 interventions intervention NNS cord-288020-vhtr3l0w 41 36 , , , cord-288020-vhtr3l0w 41 37 such such JJ cord-288020-vhtr3l0w 41 38 as as IN cord-288020-vhtr3l0w 41 39 anti anti JJ cord-288020-vhtr3l0w 41 40 - - JJ cord-288020-vhtr3l0w 41 41 inflammatory inflammatory JJ cord-288020-vhtr3l0w 41 42 or or CC cord-288020-vhtr3l0w 41 43 anti anti JJ cord-288020-vhtr3l0w 41 44 - - JJ cord-288020-vhtr3l0w 41 45 thrombotic thrombotic JJ cord-288020-vhtr3l0w 41 46 pharmacotherapy pharmacotherapy NN cord-288020-vhtr3l0w 41 47 . . . cord-288020-vhtr3l0w 42 1 To to IN cord-288020-vhtr3l0w 42 2 this this DT cord-288020-vhtr3l0w 42 3 point point NN cord-288020-vhtr3l0w 42 4 , , , cord-288020-vhtr3l0w 42 5 preliminary preliminary JJ cord-288020-vhtr3l0w 42 6 analyses analysis NNS cord-288020-vhtr3l0w 42 7 of of IN cord-288020-vhtr3l0w 42 8 the the DT cord-288020-vhtr3l0w 42 9 RECOVERY recovery NN cord-288020-vhtr3l0w 42 10 trial trial NN cord-288020-vhtr3l0w 42 11 data datum NNS cord-288020-vhtr3l0w 42 12 suggest suggest VBP cord-288020-vhtr3l0w 42 13 that that IN cord-288020-vhtr3l0w 42 14 treatment treatment NN cord-288020-vhtr3l0w 42 15 with with IN cord-288020-vhtr3l0w 42 16 dexamethasone dexamethasone NN cord-288020-vhtr3l0w 42 17 reduces reduce VBZ cord-288020-vhtr3l0w 42 18 mortality mortality NN cord-288020-vhtr3l0w 42 19 by~30 by~30 NNP cord-288020-vhtr3l0w 42 20 % % NN cord-288020-vhtr3l0w 42 21 in in IN cord-288020-vhtr3l0w 42 22 COVID-19 COVID-19 NNP cord-288020-vhtr3l0w 42 23 hospitalized hospitalize VBN cord-288020-vhtr3l0w 42 24 patients patient NNS cord-288020-vhtr3l0w 42 25 with with IN cord-288020-vhtr3l0w 42 26 supplemental supplemental JJ cord-288020-vhtr3l0w 42 27 oxygen oxygen NN cord-288020-vhtr3l0w 42 28 [ [ -LRB- cord-288020-vhtr3l0w 42 29 10 10 CD cord-288020-vhtr3l0w 42 30 ] ] -RRB- cord-288020-vhtr3l0w 42 31 . . . cord-288020-vhtr3l0w 43 1 Predictive predictive JJ cord-288020-vhtr3l0w 43 2 scores score NNS cord-288020-vhtr3l0w 43 3 that that WDT cord-288020-vhtr3l0w 43 4 include include VBP cord-288020-vhtr3l0w 43 5 blood blood NN cord-288020-vhtr3l0w 43 6 biomarkers biomarker NNS cord-288020-vhtr3l0w 43 7 of of IN cord-288020-vhtr3l0w 43 8 inflammation inflammation NN cord-288020-vhtr3l0w 43 9 may may MD cord-288020-vhtr3l0w 43 10 help help VB cord-288020-vhtr3l0w 43 11 to to TO cord-288020-vhtr3l0w 43 12 target target VB cord-288020-vhtr3l0w 43 13 the the DT cord-288020-vhtr3l0w 43 14 subset subset NN cord-288020-vhtr3l0w 43 15 of of IN cord-288020-vhtr3l0w 43 16 patients patient NNS cord-288020-vhtr3l0w 43 17 who who WP cord-288020-vhtr3l0w 43 18 should should MD cord-288020-vhtr3l0w 43 19 receive receive VB cord-288020-vhtr3l0w 43 20 dexamethasone dexamethasone NN cord-288020-vhtr3l0w 43 21 or or CC cord-288020-vhtr3l0w 43 22 other other JJ cord-288020-vhtr3l0w 43 23 anti anti JJ cord-288020-vhtr3l0w 43 24 - - JJ cord-288020-vhtr3l0w 43 25 inflammatory inflammatory JJ cord-288020-vhtr3l0w 43 26 therapy therapy NN cord-288020-vhtr3l0w 43 27 at at IN cord-288020-vhtr3l0w 43 28 an an DT cord-288020-vhtr3l0w 43 29 early early JJ cord-288020-vhtr3l0w 43 30 stage stage NN cord-288020-vhtr3l0w 43 31 of of IN cord-288020-vhtr3l0w 43 32 the the DT cord-288020-vhtr3l0w 43 33 disease disease NN cord-288020-vhtr3l0w 43 34 and and CC cord-288020-vhtr3l0w 43 35 could could MD cord-288020-vhtr3l0w 43 36 aid aid VB cord-288020-vhtr3l0w 43 37 in in IN cord-288020-vhtr3l0w 43 38 the the DT cord-288020-vhtr3l0w 43 39 optimal optimal JJ cord-288020-vhtr3l0w 43 40 design design NN cord-288020-vhtr3l0w 43 41 of of IN cord-288020-vhtr3l0w 43 42 new new JJ cord-288020-vhtr3l0w 43 43 therapeutic therapeutic JJ cord-288020-vhtr3l0w 43 44 trials trial NNS cord-288020-vhtr3l0w 43 45 . . . cord-288020-vhtr3l0w 44 1 With with IN cord-288020-vhtr3l0w 44 2 the the DT cord-288020-vhtr3l0w 44 3 COVID-19 covid-19 JJ cord-288020-vhtr3l0w 44 4 pandemic pandemic NN cord-288020-vhtr3l0w 44 5 , , , cord-288020-vhtr3l0w 44 6 the the DT cord-288020-vhtr3l0w 44 7 world world NN cord-288020-vhtr3l0w 44 8 is be VBZ cord-288020-vhtr3l0w 44 9 currently currently RB cord-288020-vhtr3l0w 44 10 facing face VBG cord-288020-vhtr3l0w 44 11 a a DT cord-288020-vhtr3l0w 44 12 major major JJ cord-288020-vhtr3l0w 44 13 health health NN cord-288020-vhtr3l0w 44 14 crisis crisis NN cord-288020-vhtr3l0w 44 15 . . . cord-288020-vhtr3l0w 45 1 An an DT cord-288020-vhtr3l0w 45 2 integrative integrative JJ cord-288020-vhtr3l0w 45 3 multi multi JJ cord-288020-vhtr3l0w 45 4 - - NN cord-288020-vhtr3l0w 45 5 parameter parameter NN cord-288020-vhtr3l0w 45 6 stepwise stepwise JJ cord-288020-vhtr3l0w 45 7 approach approach NN cord-288020-vhtr3l0w 45 8 , , , cord-288020-vhtr3l0w 45 9 such such JJ cord-288020-vhtr3l0w 45 10 as as IN cord-288020-vhtr3l0w 45 11 the the DT cord-288020-vhtr3l0w 45 12 one one NN cord-288020-vhtr3l0w 45 13 we -PRON- PRP cord-288020-vhtr3l0w 45 14 propose propose VBP cord-288020-vhtr3l0w 45 15 in in IN cord-288020-vhtr3l0w 45 16 Fig Fig NNP cord-288020-vhtr3l0w 45 17 . . . cord-288020-vhtr3l0w 46 1 1 1 LS cord-288020-vhtr3l0w 46 2 , , , cord-288020-vhtr3l0w 46 3 may may MD cord-288020-vhtr3l0w 46 4 help help VB cord-288020-vhtr3l0w 46 5 to to TO cord-288020-vhtr3l0w 46 6 optimize optimize VB cord-288020-vhtr3l0w 46 7 the the DT cord-288020-vhtr3l0w 46 8 management management NN cord-288020-vhtr3l0w 46 9 of of IN cord-288020-vhtr3l0w 46 10 patients patient NNS cord-288020-vhtr3l0w 46 11 with with IN cord-288020-vhtr3l0w 46 12 COVID-19 COVID-19 NNP cord-288020-vhtr3l0w 46 13 . . . cord-288020-vhtr3l0w 47 1 The the DT cord-288020-vhtr3l0w 47 2 HNC HNC NNP cord-288020-vhtr3l0w 47 3 - - HYPH cord-288020-vhtr3l0w 47 4 LL LL NNP cord-288020-vhtr3l0w 47 5 score score NN cord-288020-vhtr3l0w 47 6 proposed propose VBN cord-288020-vhtr3l0w 47 7 by by IN cord-288020-vhtr3l0w 47 8 Xiao Xiao NNP cord-288020-vhtr3l0w 47 9 et et NNP cord-288020-vhtr3l0w 47 10 al al NNP cord-288020-vhtr3l0w 47 11 . . . cord-288020-vhtr3l0w 48 1 in in IN cord-288020-vhtr3l0w 48 2 EBioMedicine EBioMedicine NNP cord-288020-vhtr3l0w 48 3 is be VBZ cord-288020-vhtr3l0w 48 4 a a DT cord-288020-vhtr3l0w 48 5 promising promising JJ cord-288020-vhtr3l0w 48 6 development development NN cord-288020-vhtr3l0w 48 7 but but CC cord-288020-vhtr3l0w 48 8 needs need VBZ cord-288020-vhtr3l0w 48 9 to to TO cord-288020-vhtr3l0w 48 10 be be VB cord-288020-vhtr3l0w 48 11 further further RB cord-288020-vhtr3l0w 48 12 validated validate VBN cord-288020-vhtr3l0w 48 13 in in IN cord-288020-vhtr3l0w 48 14 other other JJ cord-288020-vhtr3l0w 48 15 independent independent JJ cord-288020-vhtr3l0w 48 16 patient patient JJ cord-288020-vhtr3l0w 48 17 cohorts cohort NNS cord-288020-vhtr3l0w 48 18 in in IN cord-288020-vhtr3l0w 48 19 other other JJ cord-288020-vhtr3l0w 48 20 countries country NNS cord-288020-vhtr3l0w 48 21 and and CC cord-288020-vhtr3l0w 48 22 in in IN cord-288020-vhtr3l0w 48 23 larger large JJR cord-288020-vhtr3l0w 48 24 cohorts cohort NNS cord-288020-vhtr3l0w 48 25 with with IN cord-288020-vhtr3l0w 48 26 mild mild JJ cord-288020-vhtr3l0w 48 27 disease disease NN cord-288020-vhtr3l0w 48 28 who who WP cord-288020-vhtr3l0w 48 29 are be VBP cord-288020-vhtr3l0w 48 30 not not RB cord-288020-vhtr3l0w 48 31 yet yet RB cord-288020-vhtr3l0w 48 32 hospitalized hospitalize VBN cord-288020-vhtr3l0w 48 33 . . . cord-288020-vhtr3l0w 49 1 Furthermore furthermore RB cord-288020-vhtr3l0w 49 2 , , , cord-288020-vhtr3l0w 49 3 the the DT cord-288020-vhtr3l0w 49 4 addition addition NN cord-288020-vhtr3l0w 49 5 of of IN cord-288020-vhtr3l0w 49 6 other other JJ cord-288020-vhtr3l0w 49 7 relevant relevant JJ cord-288020-vhtr3l0w 49 8 parameters parameter NNS cord-288020-vhtr3l0w 49 9 , , , cord-288020-vhtr3l0w 49 10 symptom symptom NN cord-288020-vhtr3l0w 49 11 duration duration NN cord-288020-vhtr3l0w 49 12 and and CC cord-288020-vhtr3l0w 49 13 other other JJ cord-288020-vhtr3l0w 49 14 blood blood NN cord-288020-vhtr3l0w 49 15 biomarkers biomarker NNS cord-288020-vhtr3l0w 49 16 ( ( -LRB- cord-288020-vhtr3l0w 49 17 e.g. e.g. IN cord-288020-vhtr3l0w 49 18 Ferritin ferritin NN cord-288020-vhtr3l0w 49 19 , , , cord-288020-vhtr3l0w 49 20 D D NNP cord-288020-vhtr3l0w 49 21 - - HYPH cord-288020-vhtr3l0w 49 22 Dimers Dimers NNPS cord-288020-vhtr3l0w 49 23 or or CC cord-288020-vhtr3l0w 49 24 Troponin Troponin NNP cord-288020-vhtr3l0w 49 25 ) ) -RRB- cord-288020-vhtr3l0w 49 26 should should MD cord-288020-vhtr3l0w 49 27 be be VB cord-288020-vhtr3l0w 49 28 explored explore VBN cord-288020-vhtr3l0w 49 29 to to TO cord-288020-vhtr3l0w 49 30 determine determine VB cord-288020-vhtr3l0w 49 31 whether whether IN cord-288020-vhtr3l0w 49 32 this this DT cord-288020-vhtr3l0w 49 33 would would MD cord-288020-vhtr3l0w 49 34 improve improve VB cord-288020-vhtr3l0w 49 35 the the DT cord-288020-vhtr3l0w 49 36 predictive predictive JJ cord-288020-vhtr3l0w 49 37 value value NN cord-288020-vhtr3l0w 49 38 of of IN cord-288020-vhtr3l0w 49 39 the the DT cord-288020-vhtr3l0w 49 40 risk risk NN cord-288020-vhtr3l0w 49 41 score score NN cord-288020-vhtr3l0w 49 42 . . . cord-288020-vhtr3l0w 50 1 Another another DT cord-288020-vhtr3l0w 50 2 promising promising JJ cord-288020-vhtr3l0w 50 3 approach approach NN cord-288020-vhtr3l0w 50 4 to to TO cord-288020-vhtr3l0w 50 5 rationalize rationalize VB cord-288020-vhtr3l0w 50 6 and and CC cord-288020-vhtr3l0w 50 7 optimize optimize VB cord-288020-vhtr3l0w 50 8 the the DT cord-288020-vhtr3l0w 50 9 risk risk NN cord-288020-vhtr3l0w 50 10 stratification stratification NN cord-288020-vhtr3l0w 50 11 scores score NNS cord-288020-vhtr3l0w 50 12 for for IN cord-288020-vhtr3l0w 50 13 COVID-19 COVID-19 NNP cord-288020-vhtr3l0w 50 14 is be VBZ cord-288020-vhtr3l0w 50 15 to to TO cord-288020-vhtr3l0w 50 16 use use VB cord-288020-vhtr3l0w 50 17 artificial artificial JJ cord-288020-vhtr3l0w 50 18 intelligence intelligence NN cord-288020-vhtr3l0w 50 19 and and CC cord-288020-vhtr3l0w 50 20 machine machine NN cord-288020-vhtr3l0w 50 21 learning learn VBG cord-288020-vhtr3l0w 50 22 to to TO cord-288020-vhtr3l0w 50 23 select select VB cord-288020-vhtr3l0w 50 24 and and CC cord-288020-vhtr3l0w 50 25 include include VB cord-288020-vhtr3l0w 50 26 the the DT cord-288020-vhtr3l0w 50 27 most most RBS cord-288020-vhtr3l0w 50 28 powerful powerful JJ cord-288020-vhtr3l0w 50 29 and and CC cord-288020-vhtr3l0w 50 30 informative informative JJ cord-288020-vhtr3l0w 50 31 clinical clinical JJ cord-288020-vhtr3l0w 50 32 factors factor NNS cord-288020-vhtr3l0w 50 33 and and CC cord-288020-vhtr3l0w 50 34 blood blood NN cord-288020-vhtr3l0w 50 35 biomarkers biomarker NNS cord-288020-vhtr3l0w 50 36 into into IN cord-288020-vhtr3l0w 50 37 the the DT cord-288020-vhtr3l0w 50 38 final final JJ cord-288020-vhtr3l0w 50 39 score score NN cord-288020-vhtr3l0w 50 40 . . . cord-288020-vhtr3l0w 51 1 Developing develop VBG cord-288020-vhtr3l0w 51 2 an an DT cord-288020-vhtr3l0w 51 3 easily easily RB cord-288020-vhtr3l0w 51 4 applicable applicable JJ cord-288020-vhtr3l0w 51 5 and and CC cord-288020-vhtr3l0w 51 6 reliable reliable JJ cord-288020-vhtr3l0w 51 7 clinical clinical JJ cord-288020-vhtr3l0w 51 8 tool tool NN cord-288020-vhtr3l0w 51 9 to to TO cord-288020-vhtr3l0w 51 10 predict predict VB cord-288020-vhtr3l0w 51 11 patient patient JJ cord-288020-vhtr3l0w 51 12 outcome outcome NN cord-288020-vhtr3l0w 51 13 at at IN cord-288020-vhtr3l0w 51 14 an an DT cord-288020-vhtr3l0w 51 15 early early JJ cord-288020-vhtr3l0w 51 16 disease disease NN cord-288020-vhtr3l0w 51 17 stage stage NN cord-288020-vhtr3l0w 51 18 may may MD cord-288020-vhtr3l0w 51 19 dramatically dramatically RB cord-288020-vhtr3l0w 51 20 improve improve VB cord-288020-vhtr3l0w 51 21 the the DT cord-288020-vhtr3l0w 51 22 management management NN cord-288020-vhtr3l0w 51 23 of of IN cord-288020-vhtr3l0w 51 24 patients patient NNS cord-288020-vhtr3l0w 51 25 , , , cord-288020-vhtr3l0w 51 26 while while IN cord-288020-vhtr3l0w 51 27 ensuring ensure VBG cord-288020-vhtr3l0w 51 28 optimal optimal JJ cord-288020-vhtr3l0w 51 29 and and CC cord-288020-vhtr3l0w 51 30 rationale rationale NN cord-288020-vhtr3l0w 51 31 utilization utilization NN cord-288020-vhtr3l0w 51 32 of of IN cord-288020-vhtr3l0w 51 33 health health NN cord-288020-vhtr3l0w 51 34 care care NN cord-288020-vhtr3l0w 51 35 resources resource NNS cord-288020-vhtr3l0w 51 36 and and CC cord-288020-vhtr3l0w 51 37 providers provider NNS cord-288020-vhtr3l0w 51 38 . . . cord-288020-vhtr3l0w 51 39 _SP cord-288020-vhtr3l0w 52 1 Authors author NNS cord-288020-vhtr3l0w 52 2 have have VBP cord-288020-vhtr3l0w 52 3 nothing nothing NN cord-288020-vhtr3l0w 52 4 to to TO cord-288020-vhtr3l0w 52 5 disclose disclose VB cord-288020-vhtr3l0w 52 6 . . . cord-288020-vhtr3l0w 53 1 Development development NN cord-288020-vhtr3l0w 53 2 and and CC cord-288020-vhtr3l0w 53 3 validation validation NN cord-288020-vhtr3l0w 53 4 of of IN cord-288020-vhtr3l0w 53 5 the the DT cord-288020-vhtr3l0w 53 6 HNC HNC NNP cord-288020-vhtr3l0w 53 7 - - HYPH cord-288020-vhtr3l0w 53 8 LL LL NNP cord-288020-vhtr3l0w 53 9 score score NN cord-288020-vhtr3l0w 53 10 for for IN cord-288020-vhtr3l0w 53 11 predicting predict VBG cord-288020-vhtr3l0w 53 12 the the DT cord-288020-vhtr3l0w 53 13 severity severity NN cord-288020-vhtr3l0w 53 14 of of IN cord-288020-vhtr3l0w 53 15 coronavirus coronavirus NN cord-288020-vhtr3l0w 53 16 disease disease NN cord-288020-vhtr3l0w 53 17 2019 2019 CD cord-288020-vhtr3l0w 53 18 Sociodemographic sociodemographic JJ cord-288020-vhtr3l0w 53 19 , , , cord-288020-vhtr3l0w 53 20 clinical clinical JJ cord-288020-vhtr3l0w 53 21 and and CC cord-288020-vhtr3l0w 53 22 laboratory laboratory NN cord-288020-vhtr3l0w 53 23 factors factor NNS cord-288020-vhtr3l0w 53 24 on on IN cord-288020-vhtr3l0w 53 25 admission admission NN cord-288020-vhtr3l0w 53 26 associated associate VBN cord-288020-vhtr3l0w 53 27 with with IN cord-288020-vhtr3l0w 53 28 COVID-19 covid-19 JJ cord-288020-vhtr3l0w 53 29 mortality mortality NN cord-288020-vhtr3l0w 53 30 in in IN cord-288020-vhtr3l0w 53 31 hospitalized hospitalize VBN cord-288020-vhtr3l0w 53 32 patients patient NNS cord-288020-vhtr3l0w 53 33 : : : cord-288020-vhtr3l0w 53 34 a a DT cord-288020-vhtr3l0w 53 35 retrospective retrospective JJ cord-288020-vhtr3l0w 53 36 observational observational JJ cord-288020-vhtr3l0w 53 37 study study NN cord-288020-vhtr3l0w 53 38 Clinical Clinical NNP cord-288020-vhtr3l0w 53 39 Features Features NNPS cord-288020-vhtr3l0w 54 1 Predicting predict VBG cord-288020-vhtr3l0w 54 2 Mortality Mortality NNP cord-288020-vhtr3l0w 54 3 Risk risk NN cord-288020-vhtr3l0w 54 4 in in IN cord-288020-vhtr3l0w 54 5 Patients patient NNS cord-288020-vhtr3l0w 54 6 With with IN cord-288020-vhtr3l0w 54 7 Viral Viral NNP cord-288020-vhtr3l0w 54 8 Pneumonia pneumonia NN cord-288020-vhtr3l0w 54 9 : : : cord-288020-vhtr3l0w 54 10 the the DT cord-288020-vhtr3l0w 54 11 MuLBSTA MuLBSTA NNP cord-288020-vhtr3l0w 54 12 Score Score NNP cord-288020-vhtr3l0w 54 13 Applicability Applicability NNP cord-288020-vhtr3l0w 54 14 of of IN cord-288020-vhtr3l0w 54 15 the the DT cord-288020-vhtr3l0w 54 16 CURB-65 curb-65 JJ cord-288020-vhtr3l0w 54 17 pneumonia pneumonia NN cord-288020-vhtr3l0w 54 18 severity severity NN cord-288020-vhtr3l0w 54 19 score score NN cord-288020-vhtr3l0w 54 20 for for IN cord-288020-vhtr3l0w 54 21 outpatient outpatient NN cord-288020-vhtr3l0w 54 22 treatment treatment NN cord-288020-vhtr3l0w 54 23 of of IN cord-288020-vhtr3l0w 54 24 COVID-19 COVID-19 NNP cord-288020-vhtr3l0w 54 25 Comparison Comparison NNP cord-288020-vhtr3l0w 54 26 of of IN cord-288020-vhtr3l0w 54 27 CRB-65 CRB-65 NNP cord-288020-vhtr3l0w 54 28 and and CC cord-288020-vhtr3l0w 54 29 quick quick JJ cord-288020-vhtr3l0w 54 30 sepsis sepsis NN cord-288020-vhtr3l0w 54 31 - - HYPH cord-288020-vhtr3l0w 54 32 related relate VBN cord-288020-vhtr3l0w 54 33 organ organ NN cord-288020-vhtr3l0w 54 34 failure failure NN cord-288020-vhtr3l0w 54 35 assessment assessment NN cord-288020-vhtr3l0w 54 36 for for IN cord-288020-vhtr3l0w 54 37 predicting predict VBG cord-288020-vhtr3l0w 54 38 the the DT cord-288020-vhtr3l0w 54 39 need need NN cord-288020-vhtr3l0w 54 40 for for IN cord-288020-vhtr3l0w 54 41 intensive intensive JJ cord-288020-vhtr3l0w 54 42 respiratory respiratory NN cord-288020-vhtr3l0w 54 43 or or CC cord-288020-vhtr3l0w 54 44 vasopressor vasopressor NN cord-288020-vhtr3l0w 54 45 support support NN cord-288020-vhtr3l0w 54 46 in in IN cord-288020-vhtr3l0w 54 47 patients patient NNS cord-288020-vhtr3l0w 54 48 with with IN cord-288020-vhtr3l0w 54 49 COVID-19 COVID-19 NNP cord-288020-vhtr3l0w 54 50 Presenting present VBG cord-288020-vhtr3l0w 54 51 characteristics characteristic NNS cord-288020-vhtr3l0w 54 52 , , , cord-288020-vhtr3l0w 54 53 comorbidities comorbiditie NNS cord-288020-vhtr3l0w 54 54 , , , cord-288020-vhtr3l0w 54 55 and and CC cord-288020-vhtr3l0w 54 56 outcomes outcome NNS cord-288020-vhtr3l0w 54 57 among among IN cord-288020-vhtr3l0w 54 58 5700 5700 CD cord-288020-vhtr3l0w 54 59 patients patient NNS cord-288020-vhtr3l0w 54 60 hospitalized hospitalize VBN cord-288020-vhtr3l0w 54 61 with with IN cord-288020-vhtr3l0w 54 62 COVID-19 COVID-19 NNP cord-288020-vhtr3l0w 54 63 in in IN cord-288020-vhtr3l0w 54 64 the the DT cord-288020-vhtr3l0w 54 65 New New NNP cord-288020-vhtr3l0w 54 66 York York NNP cord-288020-vhtr3l0w 54 67 City City NNP cord-288020-vhtr3l0w 54 68 Area Area NNP cord-288020-vhtr3l0w 54 69 Association Association NNP cord-288020-vhtr3l0w 54 70 of of IN cord-288020-vhtr3l0w 54 71 cardiac cardiac JJ cord-288020-vhtr3l0w 54 72 injury injury NN cord-288020-vhtr3l0w 54 73 with with IN cord-288020-vhtr3l0w 54 74 mortality mortality NN cord-288020-vhtr3l0w 54 75 in in IN cord-288020-vhtr3l0w 54 76 hospitalized hospitalize VBN cord-288020-vhtr3l0w 54 77 patients patient NNS cord-288020-vhtr3l0w 54 78 with with IN cord-288020-vhtr3l0w 54 79 COVID-19 COVID-19 NNP cord-288020-vhtr3l0w 54 80 in in IN cord-288020-vhtr3l0w 54 81 Wuhan Wuhan NNP cord-288020-vhtr3l0w 54 82 , , , cord-288020-vhtr3l0w 54 83 China China NNP cord-288020-vhtr3l0w 54 84 Abnormal abnormal JJ cord-288020-vhtr3l0w 54 85 coagulation coagulation NN cord-288020-vhtr3l0w 54 86 parameters parameter NNS cord-288020-vhtr3l0w 54 87 are be VBP cord-288020-vhtr3l0w 54 88 associated associate VBN cord-288020-vhtr3l0w 54 89 with with IN cord-288020-vhtr3l0w 54 90 poor poor JJ cord-288020-vhtr3l0w 54 91 prognosis prognosis NN cord-288020-vhtr3l0w 54 92 in in IN cord-288020-vhtr3l0w 54 93 patients patient NNS cord-288020-vhtr3l0w 54 94 with with IN cord-288020-vhtr3l0w 54 95 novel novel JJ cord-288020-vhtr3l0w 54 96 coronavirus coronavirus NN cord-288020-vhtr3l0w 54 97 pneumonia pneumonia NN cord-288020-vhtr3l0w 54 98 COVID-19 COVID-19 NNP cord-288020-vhtr3l0w 54 99 : : : cord-288020-vhtr3l0w 54 100 consider consider VB cord-288020-vhtr3l0w 54 101 cytokine cytokine JJ cord-288020-vhtr3l0w 54 102 storm storm NN cord-288020-vhtr3l0w 54 103 syndromes syndrome NNS cord-288020-vhtr3l0w 54 104 and and CC cord-288020-vhtr3l0w 54 105 immunosuppression immunosuppression NN cord-288020-vhtr3l0w 54 106 Effect effect NN cord-288020-vhtr3l0w 54 107 of of IN cord-288020-vhtr3l0w 54 108 dexamethasone dexamethasone NN cord-288020-vhtr3l0w 54 109 in in IN cord-288020-vhtr3l0w 54 110 hospitalized hospitalize VBN cord-288020-vhtr3l0w 54 111 patients patient NNS cord-288020-vhtr3l0w 54 112 with with IN cord-288020-vhtr3l0w 54 113 COVID-19 covid-19 NN cord-288020-vhtr3l0w 54 114 : : : cord-288020-vhtr3l0w 54 115 preliminary preliminary JJ