id sid tid token lemma pos cord-286923-o4fj8kx0 1 1 key key JJ cord-286923-o4fj8kx0 1 2 : : : cord-286923-o4fj8kx0 1 3 cord-286923-o4fj8kx0 cord-286923-o4fj8kx0 NNS cord-286923-o4fj8kx0 1 4 authors author NNS cord-286923-o4fj8kx0 1 5 : : : cord-286923-o4fj8kx0 1 6 Berhan Berhan NNP cord-286923-o4fj8kx0 1 7 , , , cord-286923-o4fj8kx0 1 8 Yifru Yifru NNP cord-286923-o4fj8kx0 1 9 title title NN cord-286923-o4fj8kx0 1 10 : : : cord-286923-o4fj8kx0 2 1 What what WDT cord-286923-o4fj8kx0 2 2 immunological immunological JJ cord-286923-o4fj8kx0 2 3 and and CC cord-286923-o4fj8kx0 2 4 hormonal hormonal JJ cord-286923-o4fj8kx0 2 5 protective protective JJ cord-286923-o4fj8kx0 2 6 factors factor NNS cord-286923-o4fj8kx0 2 7 lower lower VBP cord-286923-o4fj8kx0 2 8 the the DT cord-286923-o4fj8kx0 2 9 risk risk NN cord-286923-o4fj8kx0 2 10 of of IN cord-286923-o4fj8kx0 2 11 COVID-19 covid-19 JJ cord-286923-o4fj8kx0 2 12 related related JJ cord-286923-o4fj8kx0 2 13 deaths death NNS cord-286923-o4fj8kx0 2 14 in in IN cord-286923-o4fj8kx0 2 15 pregnant pregnant JJ cord-286923-o4fj8kx0 2 16 women woman NNS cord-286923-o4fj8kx0 2 17 ? ? . cord-286923-o4fj8kx0 3 1 date date NN cord-286923-o4fj8kx0 3 2 : : : cord-286923-o4fj8kx0 3 3 2020 2020 CD cord-286923-o4fj8kx0 3 4 - - HYPH cord-286923-o4fj8kx0 3 5 07 07 CD cord-286923-o4fj8kx0 3 6 - - SYM cord-286923-o4fj8kx0 3 7 18 18 CD cord-286923-o4fj8kx0 3 8 journal journal NN cord-286923-o4fj8kx0 3 9 : : : cord-286923-o4fj8kx0 4 1 J J NNP cord-286923-o4fj8kx0 4 2 Reprod Reprod NNP cord-286923-o4fj8kx0 4 3 Immunol Immunol NNP cord-286923-o4fj8kx0 4 4 DOI DOI NNP cord-286923-o4fj8kx0 4 5 : : : cord-286923-o4fj8kx0 4 6 10.1016/ 10.1016/ CD cord-286923-o4fj8kx0 5 1 j.jri.2020.103180 j.jri.2020.103180 NNP cord-286923-o4fj8kx0 6 1 sha sha NNP cord-286923-o4fj8kx0 6 2 : : : cord-286923-o4fj8kx0 6 3 0c01cda9f5bec4a52faf2eaa494100294dad5c32 0c01cda9f5bec4a52faf2eaa494100294dad5c32 CD cord-286923-o4fj8kx0 6 4 doc_id doc_id CD cord-286923-o4fj8kx0 6 5 : : : cord-286923-o4fj8kx0 6 6 286923 286923 CD cord-286923-o4fj8kx0 6 7 cord_uid cord_uid NNS cord-286923-o4fj8kx0 6 8 : : : cord-286923-o4fj8kx0 6 9 o4fj8kx0 o4fj8kx0 CD cord-286923-o4fj8kx0 7 1 Despite despite IN cord-286923-o4fj8kx0 7 2 anticipated anticipated JJ cord-286923-o4fj8kx0 7 3 increased increased JJ cord-286923-o4fj8kx0 7 4 risk risk NN cord-286923-o4fj8kx0 7 5 of of IN cord-286923-o4fj8kx0 7 6 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 7 7 and and CC cord-286923-o4fj8kx0 7 8 increased increase VBN cord-286923-o4fj8kx0 7 9 expression expression NN cord-286923-o4fj8kx0 7 10 of of IN cord-286923-o4fj8kx0 7 11 the the DT cord-286923-o4fj8kx0 7 12 SARS SARS NNP cord-286923-o4fj8kx0 7 13 CoV-2 CoV-2 NNP cord-286923-o4fj8kx0 7 14 receptor receptor NN cord-286923-o4fj8kx0 7 15 ( ( -LRB- cord-286923-o4fj8kx0 7 16 ACE2 ACE2 NNP cord-286923-o4fj8kx0 7 17 ) ) -RRB- cord-286923-o4fj8kx0 7 18 , , , cord-286923-o4fj8kx0 7 19 the the DT cord-286923-o4fj8kx0 7 20 relatively relatively RB cord-286923-o4fj8kx0 7 21 low low JJ cord-286923-o4fj8kx0 7 22 mortality mortality NN cord-286923-o4fj8kx0 7 23 of of IN cord-286923-o4fj8kx0 7 24 pregnant pregnant JJ cord-286923-o4fj8kx0 7 25 women woman NNS cord-286923-o4fj8kx0 7 26 with with IN cord-286923-o4fj8kx0 7 27 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 7 28 has have VBZ cord-286923-o4fj8kx0 7 29 been be VBN cord-286923-o4fj8kx0 7 30 an an DT cord-286923-o4fj8kx0 7 31 area area NN cord-286923-o4fj8kx0 7 32 of of IN cord-286923-o4fj8kx0 7 33 wonder wonder NN cord-286923-o4fj8kx0 7 34 . . . cord-286923-o4fj8kx0 8 1 The the DT cord-286923-o4fj8kx0 8 2 immunological immunological JJ cord-286923-o4fj8kx0 8 3 changes change NNS cord-286923-o4fj8kx0 8 4 predominantly predominantly RB cord-286923-o4fj8kx0 8 5 inclining incline VBG cord-286923-o4fj8kx0 8 6 to to IN cord-286923-o4fj8kx0 8 7 anti anti JJ cord-286923-o4fj8kx0 8 8 - - JJ cord-286923-o4fj8kx0 8 9 inflammatory inflammatory JJ cord-286923-o4fj8kx0 8 10 state state NN cord-286923-o4fj8kx0 8 11 , , , cord-286923-o4fj8kx0 8 12 which which WDT cord-286923-o4fj8kx0 8 13 is be VBZ cord-286923-o4fj8kx0 8 14 augmented augment VBN cord-286923-o4fj8kx0 8 15 by by IN cord-286923-o4fj8kx0 8 16 placental placental JJ cord-286923-o4fj8kx0 8 17 hormones hormone NNS cord-286923-o4fj8kx0 8 18 ’ ’ POS cord-286923-o4fj8kx0 8 19 immune immune JJ cord-286923-o4fj8kx0 8 20 modulating modulate VBG cord-286923-o4fj8kx0 8 21 action action NN cord-286923-o4fj8kx0 8 22 , , , cord-286923-o4fj8kx0 8 23 looks look VBZ cord-286923-o4fj8kx0 8 24 against against IN cord-286923-o4fj8kx0 8 25 with with IN cord-286923-o4fj8kx0 8 26 COVID-19 covid-19 JJ cord-286923-o4fj8kx0 8 27 inflammatory inflammatory JJ cord-286923-o4fj8kx0 8 28 reaction reaction NN cord-286923-o4fj8kx0 8 29 leading lead VBG cord-286923-o4fj8kx0 8 30 to to IN cord-286923-o4fj8kx0 8 31 cytokine cytokine JJ cord-286923-o4fj8kx0 8 32 storm storm NN cord-286923-o4fj8kx0 8 33 and and CC cord-286923-o4fj8kx0 8 34 multiple multiple JJ cord-286923-o4fj8kx0 8 35 organ organ NN cord-286923-o4fj8kx0 8 36 failure failure NN cord-286923-o4fj8kx0 8 37 . . . cord-286923-o4fj8kx0 9 1 Unlike unlike IN cord-286923-o4fj8kx0 9 2 many many JJ cord-286923-o4fj8kx0 9 3 other other JJ cord-286923-o4fj8kx0 9 4 viral viral JJ cord-286923-o4fj8kx0 9 5 infections infection NNS cord-286923-o4fj8kx0 9 6 , , , cord-286923-o4fj8kx0 9 7 the the DT cord-286923-o4fj8kx0 9 8 bilateral bilateral JJ cord-286923-o4fj8kx0 9 9 immune immune JJ cord-286923-o4fj8kx0 9 10 activation activation NN cord-286923-o4fj8kx0 9 11 of of IN cord-286923-o4fj8kx0 9 12 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 9 13 may may MD cord-286923-o4fj8kx0 9 14 preferentially preferentially RB cord-286923-o4fj8kx0 9 15 make make VB cord-286923-o4fj8kx0 9 16 pregnant pregnant JJ cord-286923-o4fj8kx0 9 17 women woman NNS cord-286923-o4fj8kx0 9 18 at at IN cord-286923-o4fj8kx0 9 19 low low JJ cord-286923-o4fj8kx0 9 20 risk risk NN cord-286923-o4fj8kx0 9 21 . . . cord-286923-o4fj8kx0 10 1 Taking take VBG cord-286923-o4fj8kx0 10 2 the the DT cord-286923-o4fj8kx0 10 3 physiological physiological JJ cord-286923-o4fj8kx0 10 4 advantage advantage NN cord-286923-o4fj8kx0 10 5 of of IN cord-286923-o4fj8kx0 10 6 pregnant pregnant JJ cord-286923-o4fj8kx0 10 7 women woman NNS cord-286923-o4fj8kx0 10 8 , , , cord-286923-o4fj8kx0 10 9 potential potential JJ cord-286923-o4fj8kx0 10 10 clinical clinical JJ cord-286923-o4fj8kx0 10 11 trials trial NNS cord-286923-o4fj8kx0 10 12 are be VBP cord-286923-o4fj8kx0 10 13 proposed propose VBN cord-286923-o4fj8kx0 10 14 . . . cord-286923-o4fj8kx0 11 1 Quite quite PDT cord-286923-o4fj8kx0 11 2 a a DT cord-286923-o4fj8kx0 11 3 large large JJ cord-286923-o4fj8kx0 11 4 number number NN cord-286923-o4fj8kx0 11 5 of of IN cord-286923-o4fj8kx0 11 6 epidemiological epidemiological JJ cord-286923-o4fj8kx0 11 7 and and CC cord-286923-o4fj8kx0 11 8 obstetrics obstetric NNS cord-286923-o4fj8kx0 11 9 related relate VBN cord-286923-o4fj8kx0 11 10 studies study NNS cord-286923-o4fj8kx0 11 11 have have VBP cord-286923-o4fj8kx0 11 12 addressed address VBN cord-286923-o4fj8kx0 11 13 the the DT cord-286923-o4fj8kx0 11 14 cases case NNS cord-286923-o4fj8kx0 11 15 of of IN cord-286923-o4fj8kx0 11 16 women woman NNS cord-286923-o4fj8kx0 11 17 with with IN cord-286923-o4fj8kx0 11 18 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 11 19 . . . cord-286923-o4fj8kx0 12 1 However however RB cord-286923-o4fj8kx0 12 2 , , , cord-286923-o4fj8kx0 12 3 to to IN cord-286923-o4fj8kx0 12 4 the the DT cord-286923-o4fj8kx0 12 5 best good JJS cord-286923-o4fj8kx0 12 6 of of IN cord-286923-o4fj8kx0 12 7 the the DT cord-286923-o4fj8kx0 12 8 author author NN cord-286923-o4fj8kx0 12 9 's 's POS cord-286923-o4fj8kx0 12 10 knowledge knowledge NN cord-286923-o4fj8kx0 12 11 , , , cord-286923-o4fj8kx0 12 12 little little JJ cord-286923-o4fj8kx0 12 13 is be VBZ cord-286923-o4fj8kx0 12 14 done do VBN cord-286923-o4fj8kx0 12 15 to to TO cord-286923-o4fj8kx0 12 16 explore explore VB cord-286923-o4fj8kx0 12 17 the the DT cord-286923-o4fj8kx0 12 18 physiological physiological JJ cord-286923-o4fj8kx0 12 19 internal internal JJ cord-286923-o4fj8kx0 12 20 milieu milieu NN cord-286923-o4fj8kx0 12 21 of of IN cord-286923-o4fj8kx0 12 22 pregnant pregnant JJ cord-286923-o4fj8kx0 12 23 women woman NNS cord-286923-o4fj8kx0 12 24 in in IN cord-286923-o4fj8kx0 12 25 relation relation NN cord-286923-o4fj8kx0 12 26 to to IN cord-286923-o4fj8kx0 12 27 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 12 28 . . . cord-286923-o4fj8kx0 13 1 This this DT cord-286923-o4fj8kx0 13 2 review review NN cord-286923-o4fj8kx0 13 3 provides provide VBZ cord-286923-o4fj8kx0 13 4 an an DT cord-286923-o4fj8kx0 13 5 insight insight NN cord-286923-o4fj8kx0 13 6 into into IN cord-286923-o4fj8kx0 13 7 how how WRB cord-286923-o4fj8kx0 13 8 the the DT cord-286923-o4fj8kx0 13 9 hormonal hormonal JJ cord-286923-o4fj8kx0 13 10 and and CC cord-286923-o4fj8kx0 13 11 immunological immunological JJ cord-286923-o4fj8kx0 13 12 changes change NNS cord-286923-o4fj8kx0 13 13 in in IN cord-286923-o4fj8kx0 13 14 pregnancy pregnancy NN cord-286923-o4fj8kx0 13 15 potentially potentially RB cord-286923-o4fj8kx0 13 16 reduce reduce VBP cord-286923-o4fj8kx0 13 17 SARS SARS NNP cord-286923-o4fj8kx0 13 18 - - HYPH cord-286923-o4fj8kx0 13 19 CoV-2-mediated cov-2-mediate VBN cord-286923-o4fj8kx0 13 20 inflammatory inflammatory JJ cord-286923-o4fj8kx0 13 21 response response NN cord-286923-o4fj8kx0 13 22 . . . cord-286923-o4fj8kx0 14 1 Coronavirus Coronavirus NNP cord-286923-o4fj8kx0 14 2 disease disease NN cord-286923-o4fj8kx0 14 3 ( ( -LRB- cord-286923-o4fj8kx0 14 4 COVID- covid- NN cord-286923-o4fj8kx0 14 5 19 19 CD cord-286923-o4fj8kx0 14 6 ) ) -RRB- cord-286923-o4fj8kx0 14 7 was be VBD cord-286923-o4fj8kx0 14 8 first first RB cord-286923-o4fj8kx0 14 9 recognized recognize VBN cord-286923-o4fj8kx0 14 10 in in IN cord-286923-o4fj8kx0 14 11 late late JJ cord-286923-o4fj8kx0 14 12 2019 2019 CD cord-286923-o4fj8kx0 14 13 in in IN cord-286923-o4fj8kx0 14 14 Wuhan Wuhan NNP cord-286923-o4fj8kx0 14 15 / / SYM cord-286923-o4fj8kx0 14 16 China China NNP cord-286923-o4fj8kx0 14 17 as as IN cord-286923-o4fj8kx0 14 18 caused cause VBN cord-286923-o4fj8kx0 14 19 by by IN cord-286923-o4fj8kx0 14 20 severe severe JJ cord-286923-o4fj8kx0 14 21 acute acute JJ cord-286923-o4fj8kx0 14 22 respiratory respiratory JJ cord-286923-o4fj8kx0 14 23 syndrome syndrome NN cord-286923-o4fj8kx0 14 24 corona corona NN cord-286923-o4fj8kx0 14 25 virus virus NN cord-286923-o4fj8kx0 14 26 ( ( -LRB- cord-286923-o4fj8kx0 14 27 SARS SARS NNP cord-286923-o4fj8kx0 14 28 CoV-2 CoV-2 NNP cord-286923-o4fj8kx0 14 29 ) ) -RRB- cord-286923-o4fj8kx0 15 1 and and CC cord-286923-o4fj8kx0 15 2 has have VBZ cord-286923-o4fj8kx0 15 3 become become VBN cord-286923-o4fj8kx0 15 4 pandemic pandemic JJ cord-286923-o4fj8kx0 15 5 [ [ -LRB- cord-286923-o4fj8kx0 15 6 1 1 CD cord-286923-o4fj8kx0 15 7 ] ] -RRB- cord-286923-o4fj8kx0 15 8 . . . cord-286923-o4fj8kx0 16 1 In in IN cord-286923-o4fj8kx0 16 2 due due JJ cord-286923-o4fj8kx0 16 3 course course NN cord-286923-o4fj8kx0 16 4 , , , cord-286923-o4fj8kx0 16 5 among among IN cord-286923-o4fj8kx0 16 6 several several JJ cord-286923-o4fj8kx0 16 7 unprecedented unprecedented JJ cord-286923-o4fj8kx0 16 8 events event NNS cord-286923-o4fj8kx0 16 9 , , , cord-286923-o4fj8kx0 16 10 the the DT cord-286923-o4fj8kx0 16 11 relatively relatively RB cord-286923-o4fj8kx0 16 12 low low JJ cord-286923-o4fj8kx0 16 13 mortality mortality NN cord-286923-o4fj8kx0 16 14 of of IN cord-286923-o4fj8kx0 16 15 COVID-19 covid-19 CD cord-286923-o4fj8kx0 16 16 in in IN cord-286923-o4fj8kx0 16 17 pregnant pregnant JJ cord-286923-o4fj8kx0 16 18 women woman NNS cord-286923-o4fj8kx0 16 19 has have VBZ cord-286923-o4fj8kx0 16 20 been be VBN cord-286923-o4fj8kx0 16 21 an an DT cord-286923-o4fj8kx0 16 22 area area NN cord-286923-o4fj8kx0 16 23 of of IN cord-286923-o4fj8kx0 16 24 wonder wonder NN cord-286923-o4fj8kx0 16 25 . . . cord-286923-o4fj8kx0 17 1 What what WP cord-286923-o4fj8kx0 17 2 is be VBZ cord-286923-o4fj8kx0 17 3 known know VBN cord-286923-o4fj8kx0 17 4 before before RB cord-286923-o4fj8kx0 17 5 is be VBZ cord-286923-o4fj8kx0 17 6 that that IN cord-286923-o4fj8kx0 17 7 the the DT cord-286923-o4fj8kx0 17 8 immunological immunological JJ cord-286923-o4fj8kx0 17 9 change change NN cord-286923-o4fj8kx0 17 10 during during IN cord-286923-o4fj8kx0 17 11 pregnancy pregnancy NN cord-286923-o4fj8kx0 17 12 inclining incline VBG cord-286923-o4fj8kx0 17 13 to to IN cord-286923-o4fj8kx0 17 14 the the DT cord-286923-o4fj8kx0 17 15 anti anti JJ cord-286923-o4fj8kx0 17 16 - - JJ cord-286923-o4fj8kx0 17 17 inflammatory inflammatory JJ cord-286923-o4fj8kx0 17 18 state state NN cord-286923-o4fj8kx0 17 19 is be VBZ cord-286923-o4fj8kx0 17 20 for for IN cord-286923-o4fj8kx0 17 21 the the DT cord-286923-o4fj8kx0 17 22 benefit benefit NN cord-286923-o4fj8kx0 17 23 of of IN cord-286923-o4fj8kx0 17 24 the the DT cord-286923-o4fj8kx0 17 25 fetus fetus NN cord-286923-o4fj8kx0 17 26 , , , cord-286923-o4fj8kx0 17 27 but but CC cord-286923-o4fj8kx0 17 28 an an DT cord-286923-o4fj8kx0 17 29 increased increase VBN cord-286923-o4fj8kx0 17 30 risk risk NN cord-286923-o4fj8kx0 17 31 for for IN cord-286923-o4fj8kx0 17 32 the the DT cord-286923-o4fj8kx0 17 33 mother mother NN cord-286923-o4fj8kx0 17 34 to to TO cord-286923-o4fj8kx0 17 35 have have VB cord-286923-o4fj8kx0 17 36 many many JJ cord-286923-o4fj8kx0 17 37 of of IN cord-286923-o4fj8kx0 17 38 the the DT cord-286923-o4fj8kx0 17 39 viral viral JJ cord-286923-o4fj8kx0 17 40 infections infection NNS cord-286923-o4fj8kx0 17 41 ( ( -LRB- cord-286923-o4fj8kx0 17 42 predominantly predominantly RB cord-286923-o4fj8kx0 17 43 in in IN cord-286923-o4fj8kx0 17 44 the the DT cord-286923-o4fj8kx0 17 45 respiratory respiratory JJ cord-286923-o4fj8kx0 17 46 system system NN cord-286923-o4fj8kx0 17 47 ) ) -RRB- cord-286923-o4fj8kx0 17 48 and and CC cord-286923-o4fj8kx0 17 49 severity severity NN cord-286923-o4fj8kx0 17 50 of of IN cord-286923-o4fj8kx0 17 51 malaria malaria NN cord-286923-o4fj8kx0 17 52 [ [ -LRB- cord-286923-o4fj8kx0 17 53 2 2 CD cord-286923-o4fj8kx0 17 54 , , , cord-286923-o4fj8kx0 17 55 3 3 CD cord-286923-o4fj8kx0 17 56 ] ] -RRB- cord-286923-o4fj8kx0 17 57 . . . cord-286923-o4fj8kx0 18 1 Interestingly interestingly RB cord-286923-o4fj8kx0 18 2 , , , cord-286923-o4fj8kx0 18 3 pregnant pregnant JJ cord-286923-o4fj8kx0 18 4 women woman NNS cord-286923-o4fj8kx0 18 5 can can MD cord-286923-o4fj8kx0 18 6 have have VB cord-286923-o4fj8kx0 18 7 as as IN cord-286923-o4fj8kx0 18 8 remission remission NN cord-286923-o4fj8kx0 18 9 of of IN cord-286923-o4fj8kx0 18 10 symptoms symptom NNS cord-286923-o4fj8kx0 18 11 of of IN cord-286923-o4fj8kx0 18 12 many many JJ cord-286923-o4fj8kx0 18 13 of of IN cord-286923-o4fj8kx0 18 14 the the DT cord-286923-o4fj8kx0 18 15 autoimmune autoimmune JJ cord-286923-o4fj8kx0 18 16 diseases disease NNS cord-286923-o4fj8kx0 18 17 as as IN cord-286923-o4fj8kx0 18 18 noted note VBN cord-286923-o4fj8kx0 18 19 below below IN cord-286923-o4fj8kx0 18 20 [ [ -LRB- cord-286923-o4fj8kx0 18 21 4 4 CD cord-286923-o4fj8kx0 18 22 , , , cord-286923-o4fj8kx0 18 23 5 5 CD cord-286923-o4fj8kx0 18 24 ] ] -RRB- cord-286923-o4fj8kx0 18 25 . . . cord-286923-o4fj8kx0 19 1 It -PRON- PRP cord-286923-o4fj8kx0 19 2 looks look VBZ cord-286923-o4fj8kx0 19 3 that that IN cord-286923-o4fj8kx0 19 4 autoimmune autoimmune JJ cord-286923-o4fj8kx0 19 5 diseases disease NNS cord-286923-o4fj8kx0 19 6 and and CC cord-286923-o4fj8kx0 19 7 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 19 8 have have VBP cord-286923-o4fj8kx0 19 9 something something NN cord-286923-o4fj8kx0 19 10 in in IN cord-286923-o4fj8kx0 19 11 common common JJ cord-286923-o4fj8kx0 19 12 during during IN cord-286923-o4fj8kx0 19 13 pregnancy pregnancy NN cord-286923-o4fj8kx0 19 14 . . . cord-286923-o4fj8kx0 20 1 Previous previous JJ cord-286923-o4fj8kx0 20 2 studies study NNS cord-286923-o4fj8kx0 20 3 have have VBP cord-286923-o4fj8kx0 20 4 shown show VBN cord-286923-o4fj8kx0 20 5 that that IN cord-286923-o4fj8kx0 20 6 pregnant pregnant JJ cord-286923-o4fj8kx0 20 7 women woman NNS cord-286923-o4fj8kx0 20 8 are be VBP cord-286923-o4fj8kx0 20 9 at at IN cord-286923-o4fj8kx0 20 10 increased increase VBN cord-286923-o4fj8kx0 20 11 risk risk NN cord-286923-o4fj8kx0 20 12 of of IN cord-286923-o4fj8kx0 20 13 morbidity morbidity NN cord-286923-o4fj8kx0 20 14 and and CC cord-286923-o4fj8kx0 20 15 mortality mortality NN cord-286923-o4fj8kx0 20 16 due due IN cord-286923-o4fj8kx0 20 17 to to IN cord-286923-o4fj8kx0 20 18 many many JJ cord-286923-o4fj8kx0 20 19 of of IN cord-286923-o4fj8kx0 20 20 the the DT cord-286923-o4fj8kx0 20 21 fatal fatal JJ cord-286923-o4fj8kx0 20 22 viral viral JJ cord-286923-o4fj8kx0 20 23 infections infection NNS cord-286923-o4fj8kx0 20 24 , , , cord-286923-o4fj8kx0 20 25 including include VBG cord-286923-o4fj8kx0 20 26 hepatitis hepatitis NN cord-286923-o4fj8kx0 20 27 E e NN cord-286923-o4fj8kx0 20 28 virus virus NN cord-286923-o4fj8kx0 20 29 , , , cord-286923-o4fj8kx0 20 30 influenza influenza NN cord-286923-o4fj8kx0 20 31 A a DT cord-286923-o4fj8kx0 20 32 virus virus NN cord-286923-o4fj8kx0 20 33 , , , cord-286923-o4fj8kx0 20 34 SARS SARS NNP cord-286923-o4fj8kx0 20 35 CoV CoV NNP cord-286923-o4fj8kx0 20 36 , , , cord-286923-o4fj8kx0 20 37 and and CC cord-286923-o4fj8kx0 20 38 MERS MERS NNP cord-286923-o4fj8kx0 20 39 CoV CoV NNP cord-286923-o4fj8kx0 20 40 [ [ -LRB- cord-286923-o4fj8kx0 20 41 6 6 CD cord-286923-o4fj8kx0 20 42 , , , cord-286923-o4fj8kx0 20 43 7 7 CD cord-286923-o4fj8kx0 20 44 ] ] -RRB- cord-286923-o4fj8kx0 20 45 . . . cord-286923-o4fj8kx0 21 1 Table table NN cord-286923-o4fj8kx0 21 2 1 1 CD cord-286923-o4fj8kx0 21 3 summarizes summarize VBZ cord-286923-o4fj8kx0 21 4 the the DT cord-286923-o4fj8kx0 21 5 comparative comparative JJ cord-286923-o4fj8kx0 21 6 maternal maternal JJ cord-286923-o4fj8kx0 21 7 mortality mortality NN cord-286923-o4fj8kx0 21 8 risks risk NNS cord-286923-o4fj8kx0 21 9 in in IN cord-286923-o4fj8kx0 21 10 different different JJ cord-286923-o4fj8kx0 21 11 infection infection NN cord-286923-o4fj8kx0 21 12 outbreaks outbreak NNS cord-286923-o4fj8kx0 21 13 over over IN cord-286923-o4fj8kx0 21 14 the the DT cord-286923-o4fj8kx0 21 15 past past JJ cord-286923-o4fj8kx0 21 16 two two CD cord-286923-o4fj8kx0 21 17 decades decade NNS cord-286923-o4fj8kx0 21 18 [ [ -LRB- cord-286923-o4fj8kx0 21 19 8 8 CD cord-286923-o4fj8kx0 21 20 ] ] -RRB- cord-286923-o4fj8kx0 22 1 [ [ -LRB- cord-286923-o4fj8kx0 22 2 9 9 CD cord-286923-o4fj8kx0 22 3 ] ] -RRB- cord-286923-o4fj8kx0 22 4 [ [ -LRB- cord-286923-o4fj8kx0 22 5 10 10 CD cord-286923-o4fj8kx0 22 6 ] ] -RRB- cord-286923-o4fj8kx0 22 7 [ [ -LRB- cord-286923-o4fj8kx0 22 8 11 11 CD cord-286923-o4fj8kx0 22 9 ] ] -RRB- cord-286923-o4fj8kx0 22 10 [ [ -LRB- cord-286923-o4fj8kx0 22 11 12 12 CD cord-286923-o4fj8kx0 22 12 ] ] -RRB- cord-286923-o4fj8kx0 22 13 [ [ -LRB- cord-286923-o4fj8kx0 22 14 13 13 CD cord-286923-o4fj8kx0 22 15 ] ] -RRB- cord-286923-o4fj8kx0 23 1 [ [ -LRB- cord-286923-o4fj8kx0 23 2 14 14 CD cord-286923-o4fj8kx0 23 3 ] ] -RRB- cord-286923-o4fj8kx0 24 1 [ [ -LRB- cord-286923-o4fj8kx0 24 2 15 15 CD cord-286923-o4fj8kx0 24 3 ] ] -RRB- cord-286923-o4fj8kx0 24 4 [ [ -LRB- cord-286923-o4fj8kx0 24 5 16 16 CD cord-286923-o4fj8kx0 24 6 ] ] -RRB- cord-286923-o4fj8kx0 24 7 [ [ -LRB- cord-286923-o4fj8kx0 24 8 17 17 CD cord-286923-o4fj8kx0 24 9 ] ] -RRB- cord-286923-o4fj8kx0 24 10 [ [ -LRB- cord-286923-o4fj8kx0 24 11 18 18 CD cord-286923-o4fj8kx0 24 12 ] ] -RRB- cord-286923-o4fj8kx0 24 13 . . . cord-286923-o4fj8kx0 25 1 The the DT cord-286923-o4fj8kx0 25 2 systematic systematic JJ cord-286923-o4fj8kx0 25 3 review review NN cord-286923-o4fj8kx0 25 4 of of IN cord-286923-o4fj8kx0 25 5 108 108 CD cord-286923-o4fj8kx0 25 6 pregnant pregnant JJ cord-286923-o4fj8kx0 25 7 women woman NNS cord-286923-o4fj8kx0 25 8 from from IN cord-286923-o4fj8kx0 25 9 different different JJ cord-286923-o4fj8kx0 25 10 countries country NNS cord-286923-o4fj8kx0 25 11 has have VBZ cord-286923-o4fj8kx0 25 12 shown show VBN cord-286923-o4fj8kx0 25 13 that that IN cord-286923-o4fj8kx0 25 14 severe severe JJ cord-286923-o4fj8kx0 25 15 infections infection NNS cord-286923-o4fj8kx0 25 16 were be VBD cord-286923-o4fj8kx0 25 17 relatively relatively RB cord-286923-o4fj8kx0 25 18 uncommon uncommon JJ cord-286923-o4fj8kx0 25 19 and and CC cord-286923-o4fj8kx0 25 20 there there EX cord-286923-o4fj8kx0 25 21 was be VBD cord-286923-o4fj8kx0 25 22 no no DT cord-286923-o4fj8kx0 25 23 maternal maternal JJ cord-286923-o4fj8kx0 25 24 death death NN cord-286923-o4fj8kx0 25 25 as as IN cord-286923-o4fj8kx0 25 26 compared compare VBN cord-286923-o4fj8kx0 25 27 to to IN cord-286923-o4fj8kx0 25 28 the the DT cord-286923-o4fj8kx0 25 29 aforementioned aforementioned JJ cord-286923-o4fj8kx0 25 30 viral viral JJ cord-286923-o4fj8kx0 25 31 infections infection NNS cord-286923-o4fj8kx0 25 32 [ [ -LRB- cord-286923-o4fj8kx0 25 33 14 14 CD cord-286923-o4fj8kx0 25 34 ] ] -RRB- cord-286923-o4fj8kx0 25 35 . . . cord-286923-o4fj8kx0 26 1 Report report NN cord-286923-o4fj8kx0 26 2 of of IN cord-286923-o4fj8kx0 26 3 the the DT cord-286923-o4fj8kx0 26 4 WHO WHO NNP cord-286923-o4fj8kx0 26 5 - - HYPH cord-286923-o4fj8kx0 26 6 China China NNP cord-286923-o4fj8kx0 26 7 Joint Joint NNP cord-286923-o4fj8kx0 26 8 Mission Mission NNP cord-286923-o4fj8kx0 26 9 has have VBZ cord-286923-o4fj8kx0 26 10 also also RB cord-286923-o4fj8kx0 26 11 concluded conclude VBN cord-286923-o4fj8kx0 26 12 that that IN cord-286923-o4fj8kx0 26 13 severe severe JJ cord-286923-o4fj8kx0 26 14 disease disease NN cord-286923-o4fj8kx0 26 15 due due IN cord-286923-o4fj8kx0 26 16 to to IN cord-286923-o4fj8kx0 26 17 SARS SARS NNP cord-286923-o4fj8kx0 26 18 CoV-2 CoV-2 NNP cord-286923-o4fj8kx0 26 19 infection infection NN cord-286923-o4fj8kx0 26 20 was be VBD cord-286923-o4fj8kx0 26 21 uncommon uncommon JJ cord-286923-o4fj8kx0 26 22 among among IN cord-286923-o4fj8kx0 26 23 pregnant pregnant JJ cord-286923-o4fj8kx0 26 24 women woman NNS cord-286923-o4fj8kx0 26 25 [ [ -LRB- cord-286923-o4fj8kx0 26 26 17 17 CD cord-286923-o4fj8kx0 26 27 ] ] -RRB- cord-286923-o4fj8kx0 26 28 . . . cord-286923-o4fj8kx0 27 1 As as IN cord-286923-o4fj8kx0 27 2 an an DT cord-286923-o4fj8kx0 27 3 unpublished unpublished JJ cord-286923-o4fj8kx0 27 4 data data NN cord-286923-o4fj8kx0 27 5 shows show NNS cord-286923-o4fj8kx0 27 6 , , , cord-286923-o4fj8kx0 27 7 the the DT cord-286923-o4fj8kx0 27 8 infection infection NN cord-286923-o4fj8kx0 27 9 rate rate NN cord-286923-o4fj8kx0 27 10 of of IN cord-286923-o4fj8kx0 27 11 COVID-19 covid-19 DT cord-286923-o4fj8kx0 27 12 to to IN cord-286923-o4fj8kx0 27 13 pregnant pregnant JJ cord-286923-o4fj8kx0 27 14 women woman NNS cord-286923-o4fj8kx0 27 15 , , , cord-286923-o4fj8kx0 27 16 however however RB cord-286923-o4fj8kx0 27 17 , , , cord-286923-o4fj8kx0 27 18 is be VBZ cord-286923-o4fj8kx0 27 19 not not RB cord-286923-o4fj8kx0 27 20 different different JJ cord-286923-o4fj8kx0 27 21 from from IN cord-286923-o4fj8kx0 27 22 the the DT cord-286923-o4fj8kx0 27 23 general general JJ cord-286923-o4fj8kx0 27 24 population population NN cord-286923-o4fj8kx0 27 25 . . . cord-286923-o4fj8kx0 28 1 So so RB cord-286923-o4fj8kx0 28 2 , , , cord-286923-o4fj8kx0 28 3 multiple multiple JJ cord-286923-o4fj8kx0 28 4 cases case NNS cord-286923-o4fj8kx0 28 5 series series NN cord-286923-o4fj8kx0 28 6 reviews review NNS cord-286923-o4fj8kx0 28 7 have have VBP cord-286923-o4fj8kx0 28 8 demonstrated demonstrate VBN cord-286923-o4fj8kx0 28 9 that that DT cord-286923-o4fj8kx0 28 10 pregnancy pregnancy NN cord-286923-o4fj8kx0 28 11 did do VBD cord-286923-o4fj8kx0 28 12 not not RB cord-286923-o4fj8kx0 28 13 add add VB cord-286923-o4fj8kx0 28 14 risk risk NN cord-286923-o4fj8kx0 28 15 to to IN cord-286923-o4fj8kx0 28 16 deterioration deterioration NN cord-286923-o4fj8kx0 28 17 due due IN cord-286923-o4fj8kx0 28 18 to to IN cord-286923-o4fj8kx0 28 19 SARS SARS NNP cord-286923-o4fj8kx0 28 20 CoV-2 CoV-2 NNP cord-286923-o4fj8kx0 28 21 infection infection NN cord-286923-o4fj8kx0 28 22 [ [ -LRB- cord-286923-o4fj8kx0 28 23 14 14 CD cord-286923-o4fj8kx0 28 24 , , , cord-286923-o4fj8kx0 28 25 19 19 CD cord-286923-o4fj8kx0 28 26 , , , cord-286923-o4fj8kx0 28 27 20 20 CD cord-286923-o4fj8kx0 28 28 ] ] -RRB- cord-286923-o4fj8kx0 28 29 . . . cord-286923-o4fj8kx0 29 1 The the DT cord-286923-o4fj8kx0 29 2 second second RB cord-286923-o4fj8kx0 29 3 largest large JJS cord-286923-o4fj8kx0 29 4 cohort cohort NN cord-286923-o4fj8kx0 29 5 study study NN cord-286923-o4fj8kx0 29 6 has have VBZ cord-286923-o4fj8kx0 29 7 shown show VBN cord-286923-o4fj8kx0 29 8 that that IN cord-286923-o4fj8kx0 29 9 427 427 CD cord-286923-o4fj8kx0 29 10 pregnant pregnant JJ cord-286923-o4fj8kx0 29 11 women woman NNS cord-286923-o4fj8kx0 29 12 ( ( -LRB- cord-286923-o4fj8kx0 29 13 0.5 0.5 CD cord-286923-o4fj8kx0 29 14 % % NN cord-286923-o4fj8kx0 29 15 of of IN cord-286923-o4fj8kx0 29 16 estimated estimate VBN cord-286923-o4fj8kx0 29 17 maternity maternity NN cord-286923-o4fj8kx0 29 18 across across IN cord-286923-o4fj8kx0 29 19 the the DT cord-286923-o4fj8kx0 29 20 UK UK NNP cord-286923-o4fj8kx0 29 21 ) ) -RRB- cord-286923-o4fj8kx0 29 22 with with IN cord-286923-o4fj8kx0 29 23 confirmed confirm VBN cord-286923-o4fj8kx0 29 24 SARS SARS NNP cord-286923-o4fj8kx0 29 25 - - HYPH cord-286923-o4fj8kx0 29 26 CoV-2 CoV-2 NNP cord-286923-o4fj8kx0 29 27 infection infection NN cord-286923-o4fj8kx0 29 28 were be VBD cord-286923-o4fj8kx0 29 29 hospitalized hospitalize VBN cord-286923-o4fj8kx0 29 30 in in IN cord-286923-o4fj8kx0 29 31 about about RB cord-286923-o4fj8kx0 29 32 one one CD cord-286923-o4fj8kx0 29 33 and and CC cord-286923-o4fj8kx0 29 34 half half NN cord-286923-o4fj8kx0 29 35 months month NNS cord-286923-o4fj8kx0 29 36 , , , cord-286923-o4fj8kx0 29 37 dominantly dominantly RB cord-286923-o4fj8kx0 29 38 black black JJ cord-286923-o4fj8kx0 29 39 and and CC cord-286923-o4fj8kx0 29 40 minor minor JJ cord-286923-o4fj8kx0 29 41 ethnicity ethnicity NN cord-286923-o4fj8kx0 29 42 with with IN cord-286923-o4fj8kx0 29 43 preexisting preexisting JJ cord-286923-o4fj8kx0 29 44 co co NNS cord-286923-o4fj8kx0 29 45 - - NNS cord-286923-o4fj8kx0 29 46 morbidities morbidity NNS cord-286923-o4fj8kx0 29 47 , , , cord-286923-o4fj8kx0 29 48 overweight overweight JJ cord-286923-o4fj8kx0 29 49 / / SYM cord-286923-o4fj8kx0 29 50 obesity obesity NN cord-286923-o4fj8kx0 29 51 , , , cord-286923-o4fj8kx0 29 52 and and CC cord-286923-o4fj8kx0 29 53 older old JJR cord-286923-o4fj8kx0 29 54 maternal maternal JJ cord-286923-o4fj8kx0 29 55 age age NN cord-286923-o4fj8kx0 29 56 [ [ -LRB- cord-286923-o4fj8kx0 29 57 13 13 CD cord-286923-o4fj8kx0 29 58 ] ] -RRB- cord-286923-o4fj8kx0 29 59 . . . cord-286923-o4fj8kx0 30 1 In in IN cord-286923-o4fj8kx0 30 2 the the DT cord-286923-o4fj8kx0 30 3 same same JJ cord-286923-o4fj8kx0 30 4 study study NN cord-286923-o4fj8kx0 30 5 , , , cord-286923-o4fj8kx0 30 6 40(9 40(9 CD cord-286923-o4fj8kx0 30 7 % % NN cord-286923-o4fj8kx0 30 8 ) ) -RRB- cord-286923-o4fj8kx0 30 9 required require VBD cord-286923-o4fj8kx0 30 10 critical critical JJ cord-286923-o4fj8kx0 30 11 care care NN cord-286923-o4fj8kx0 30 12 ( ( -LRB- cord-286923-o4fj8kx0 30 13 the the DT cord-286923-o4fj8kx0 30 14 majority majority NN cord-286923-o4fj8kx0 30 15 in in IN cord-286923-o4fj8kx0 30 16 the the DT cord-286923-o4fj8kx0 30 17 third third JJ cord-286923-o4fj8kx0 30 18 trimester trimester NN cord-286923-o4fj8kx0 30 19 ) ) -RRB- cord-286923-o4fj8kx0 30 20 ; ; : cord-286923-o4fj8kx0 30 21 4(0.9 4(0.9 CD cord-286923-o4fj8kx0 30 22 % % NN cord-286923-o4fj8kx0 30 23 ) ) -RRB- cord-286923-o4fj8kx0 30 24 required require VBN cord-286923-o4fj8kx0 30 25 cardiopulmonary cardiopulmonary JJ cord-286923-o4fj8kx0 30 26 life life NN cord-286923-o4fj8kx0 30 27 support support NN cord-286923-o4fj8kx0 30 28 ; ; : cord-286923-o4fj8kx0 30 29 5(1.2 5(1.2 CD cord-286923-o4fj8kx0 30 30 % % NN cord-286923-o4fj8kx0 30 31 ) ) -RRB- cord-286923-o4fj8kx0 30 32 died die VBD cord-286923-o4fj8kx0 30 33 ; ; : cord-286923-o4fj8kx0 30 34 and and CC cord-286923-o4fj8kx0 30 35 was be VBD cord-286923-o4fj8kx0 30 36 concluded conclude VBN cord-286923-o4fj8kx0 30 37 that that IN cord-286923-o4fj8kx0 30 38 most most JJS cord-286923-o4fj8kx0 30 39 women woman NNS cord-286923-o4fj8kx0 30 40 do do VBP cord-286923-o4fj8kx0 30 41 not not RB cord-286923-o4fj8kx0 30 42 have have VB cord-286923-o4fj8kx0 30 43 severe severe JJ cord-286923-o4fj8kx0 30 44 illness illness NN cord-286923-o4fj8kx0 30 45 . . . cord-286923-o4fj8kx0 31 1 The the DT cord-286923-o4fj8kx0 31 2 USA USA NNP cord-286923-o4fj8kx0 31 3 cohort cohort NN cord-286923-o4fj8kx0 31 4 study study NN cord-286923-o4fj8kx0 31 5 has have VBZ cord-286923-o4fj8kx0 31 6 shown show VBN cord-286923-o4fj8kx0 31 7 an an DT cord-286923-o4fj8kx0 31 8 increased increase VBN cord-286923-o4fj8kx0 31 9 risk risk NN cord-286923-o4fj8kx0 31 10 of of IN cord-286923-o4fj8kx0 31 11 hospitalization hospitalization NN cord-286923-o4fj8kx0 31 12 and and CC cord-286923-o4fj8kx0 31 13 intensive intensive JJ cord-286923-o4fj8kx0 31 14 care care NN cord-286923-o4fj8kx0 31 15 unit unit NN cord-286923-o4fj8kx0 31 16 admission admission NN cord-286923-o4fj8kx0 31 17 ( ( -LRB- cord-286923-o4fj8kx0 31 18 ICU ICU NNP cord-286923-o4fj8kx0 31 19 ) ) -RRB- cord-286923-o4fj8kx0 31 20 , , , cord-286923-o4fj8kx0 31 21 but but CC cord-286923-o4fj8kx0 31 22 not not RB cord-286923-o4fj8kx0 31 23 death death NN cord-286923-o4fj8kx0 31 24 ; ; : cord-286923-o4fj8kx0 31 25 out out IN cord-286923-o4fj8kx0 31 26 of of IN cord-286923-o4fj8kx0 31 27 8207 8207 CD cord-286923-o4fj8kx0 31 28 pregnant pregnant JJ cord-286923-o4fj8kx0 31 29 women woman NNS cord-286923-o4fj8kx0 31 30 with with IN cord-286923-o4fj8kx0 31 31 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 31 32 , , , cord-286923-o4fj8kx0 31 33 the the DT cord-286923-o4fj8kx0 31 34 proportion proportion NN cord-286923-o4fj8kx0 31 35 of of IN cord-286923-o4fj8kx0 31 36 death death NN cord-286923-o4fj8kx0 31 37 was be VBD cord-286923-o4fj8kx0 31 38 0.2 0.2 CD cord-286923-o4fj8kx0 31 39 % % NN cord-286923-o4fj8kx0 31 40 [ [ -LRB- cord-286923-o4fj8kx0 31 41 18 18 CD cord-286923-o4fj8kx0 31 42 ] ] -RRB- cord-286923-o4fj8kx0 31 43 . . . cord-286923-o4fj8kx0 32 1 The the DT cord-286923-o4fj8kx0 32 2 big big JJ cord-286923-o4fj8kx0 32 3 limitation limitation NN cord-286923-o4fj8kx0 32 4 of of IN cord-286923-o4fj8kx0 32 5 these these DT cord-286923-o4fj8kx0 32 6 two two CD cord-286923-o4fj8kx0 32 7 studies study NNS cord-286923-o4fj8kx0 32 8 was be VBD cord-286923-o4fj8kx0 32 9 that that IN cord-286923-o4fj8kx0 32 10 pregnancy pregnancy NN cord-286923-o4fj8kx0 32 11 related relate VBN cord-286923-o4fj8kx0 32 12 problems problem NNS cord-286923-o4fj8kx0 32 13 for for IN cord-286923-o4fj8kx0 32 14 hospitalization hospitalization NN cord-286923-o4fj8kx0 32 15 and and CC cord-286923-o4fj8kx0 33 1 ICU ICU NNP cord-286923-o4fj8kx0 33 2 care care NN cord-286923-o4fj8kx0 33 3 were be VBD cord-286923-o4fj8kx0 33 4 not not RB cord-286923-o4fj8kx0 33 5 included include VBN cord-286923-o4fj8kx0 33 6 in in IN cord-286923-o4fj8kx0 33 7 the the DT cord-286923-o4fj8kx0 33 8 reports report NNS cord-286923-o4fj8kx0 33 9 . . . cord-286923-o4fj8kx0 34 1 This this DT cord-286923-o4fj8kx0 34 2 is be VBZ cord-286923-o4fj8kx0 34 3 despite despite IN cord-286923-o4fj8kx0 34 4 anticipated anticipate VBN cord-286923-o4fj8kx0 34 5 increased increased JJ cord-286923-o4fj8kx0 34 6 risk risk NN cord-286923-o4fj8kx0 34 7 of of IN cord-286923-o4fj8kx0 34 8 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 34 9 ( ( -LRB- cord-286923-o4fj8kx0 34 10 taking take VBG cord-286923-o4fj8kx0 34 11 their -PRON- PRP$ cord-286923-o4fj8kx0 34 12 high high JJ cord-286923-o4fj8kx0 34 13 vulnerability vulnerability NN cord-286923-o4fj8kx0 34 14 to to IN cord-286923-o4fj8kx0 34 15 viral viral JJ cord-286923-o4fj8kx0 34 16 infections infection NNS cord-286923-o4fj8kx0 34 17 ) ) -RRB- cord-286923-o4fj8kx0 34 18 [ [ -LRB- cord-286923-o4fj8kx0 34 19 2 2 CD cord-286923-o4fj8kx0 34 20 ] ] -RRB- cord-286923-o4fj8kx0 34 21 , , , cord-286923-o4fj8kx0 34 22 and and CC cord-286923-o4fj8kx0 34 23 increased increase VBN cord-286923-o4fj8kx0 34 24 expression expression NN cord-286923-o4fj8kx0 34 25 of of IN cord-286923-o4fj8kx0 34 26 the the DT cord-286923-o4fj8kx0 34 27 SARS SARS NNP cord-286923-o4fj8kx0 34 28 CoV-2 CoV-2 NNP cord-286923-o4fj8kx0 34 29 receptor receptor NN cord-286923-o4fj8kx0 34 30 ( ( -LRB- cord-286923-o4fj8kx0 34 31 angiotensin angiotensin NN cord-286923-o4fj8kx0 34 32 converting convert VBG cord-286923-o4fj8kx0 34 33 enzyme enzyme NN cord-286923-o4fj8kx0 34 34 / / SYM cord-286923-o4fj8kx0 34 35 ACE2 ACE2 NNP cord-286923-o4fj8kx0 34 36 ) ) -RRB- cord-286923-o4fj8kx0 34 37 [ [ -LRB- cord-286923-o4fj8kx0 34 38 21 21 CD cord-286923-o4fj8kx0 34 39 ] ] -RRB- cord-286923-o4fj8kx0 34 40 . . . cord-286923-o4fj8kx0 35 1 A a DT cord-286923-o4fj8kx0 35 2 recent recent JJ cord-286923-o4fj8kx0 35 3 review review NN cord-286923-o4fj8kx0 35 4 by by IN cord-286923-o4fj8kx0 35 5 Liu Liu NNP cord-286923-o4fj8kx0 35 6 and and CC cord-286923-o4fj8kx0 35 7 colleagues colleague NNS cord-286923-o4fj8kx0 35 8 have have VBP cord-286923-o4fj8kx0 35 9 also also RB cord-286923-o4fj8kx0 35 10 predicted predict VBN cord-286923-o4fj8kx0 35 11 as as IN cord-286923-o4fj8kx0 35 12 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 35 13 may may MD cord-286923-o4fj8kx0 35 14 be be VB cord-286923-o4fj8kx0 35 15 altering alter VBG cord-286923-o4fj8kx0 35 16 the the DT cord-286923-o4fj8kx0 35 17 maternal maternal JJ cord-286923-o4fj8kx0 35 18 immune immune JJ cord-286923-o4fj8kx0 35 19 responses response NNS cord-286923-o4fj8kx0 35 20 , , , cord-286923-o4fj8kx0 35 21 and and CC cord-286923-o4fj8kx0 35 22 affect affect VB cord-286923-o4fj8kx0 35 23 the the DT cord-286923-o4fj8kx0 35 24 well well NN cord-286923-o4fj8kx0 35 25 - - HYPH cord-286923-o4fj8kx0 35 26 being being NN cord-286923-o4fj8kx0 35 27 of of IN cord-286923-o4fj8kx0 35 28 mothers mother NNS cord-286923-o4fj8kx0 35 29 and and CC cord-286923-o4fj8kx0 35 30 their -PRON- PRP$ cord-286923-o4fj8kx0 35 31 babies baby NNS cord-286923-o4fj8kx0 35 32 [ [ -LRB- cord-286923-o4fj8kx0 35 33 22 22 CD cord-286923-o4fj8kx0 35 34 ] ] -RRB- cord-286923-o4fj8kx0 35 35 . . . cord-286923-o4fj8kx0 36 1 Hereunder Hereunder NNP cord-286923-o4fj8kx0 36 2 , , , cord-286923-o4fj8kx0 36 3 in in IN cord-286923-o4fj8kx0 36 4 depth depth NN cord-286923-o4fj8kx0 36 5 review review NN cord-286923-o4fj8kx0 36 6 of of IN cord-286923-o4fj8kx0 36 7 the the DT cord-286923-o4fj8kx0 36 8 multisystem multisystem JJ cord-286923-o4fj8kx0 36 9 physiological physiological JJ cord-286923-o4fj8kx0 36 10 changes change NNS cord-286923-o4fj8kx0 36 11 in in IN cord-286923-o4fj8kx0 36 12 pregnancy pregnancy NN cord-286923-o4fj8kx0 36 13 as as IN cord-286923-o4fj8kx0 36 14 protective protective JJ cord-286923-o4fj8kx0 36 15 factor factor NN cord-286923-o4fj8kx0 36 16 , , , cord-286923-o4fj8kx0 36 17 which which WDT cord-286923-o4fj8kx0 36 18 may may MD cord-286923-o4fj8kx0 36 19 show show VB cord-286923-o4fj8kx0 36 20 the the DT cord-286923-o4fj8kx0 36 21 window window NN cord-286923-o4fj8kx0 36 22 of of IN cord-286923-o4fj8kx0 36 23 acumen acumen NN cord-286923-o4fj8kx0 36 24 to to TO cord-286923-o4fj8kx0 36 25 search search VB cord-286923-o4fj8kx0 36 26 for for IN cord-286923-o4fj8kx0 36 27 a a DT cord-286923-o4fj8kx0 36 28 possible possible JJ cord-286923-o4fj8kx0 36 29 remedy remedy NN cord-286923-o4fj8kx0 36 30 for for IN cord-286923-o4fj8kx0 36 31 those those DT cord-286923-o4fj8kx0 36 32 who who WP cord-286923-o4fj8kx0 36 33 developed develop VBD cord-286923-o4fj8kx0 36 34 the the DT cord-286923-o4fj8kx0 36 35 disease disease NN cord-286923-o4fj8kx0 36 36 of of IN cord-286923-o4fj8kx0 36 37 SARS SARS NNP cord-286923-o4fj8kx0 36 38 CoV-2 CoV-2 NNP cord-286923-o4fj8kx0 36 39 . . . cord-286923-o4fj8kx0 37 1 Therefore therefore RB cord-286923-o4fj8kx0 37 2 , , , cord-286923-o4fj8kx0 37 3 the the DT cord-286923-o4fj8kx0 37 4 purpose purpose NN cord-286923-o4fj8kx0 37 5 of of IN cord-286923-o4fj8kx0 37 6 this this DT cord-286923-o4fj8kx0 37 7 review review NN cord-286923-o4fj8kx0 37 8 is be VBZ cord-286923-o4fj8kx0 37 9 primarily primarily RB cord-286923-o4fj8kx0 37 10 to to TO cord-286923-o4fj8kx0 37 11 give give VB cord-286923-o4fj8kx0 37 12 an an DT cord-286923-o4fj8kx0 37 13 insight insight NN cord-286923-o4fj8kx0 37 14 on on IN cord-286923-o4fj8kx0 37 15 the the DT cord-286923-o4fj8kx0 37 16 physiological physiological JJ cord-286923-o4fj8kx0 37 17 and and CC cord-286923-o4fj8kx0 37 18 immunological immunological JJ cord-286923-o4fj8kx0 37 19 changes change NNS cord-286923-o4fj8kx0 37 20 of of IN cord-286923-o4fj8kx0 37 21 pregnancy pregnancy NN cord-286923-o4fj8kx0 37 22 and and CC cord-286923-o4fj8kx0 37 23 shed shed VBD cord-286923-o4fj8kx0 37 24 light light NN cord-286923-o4fj8kx0 37 25 on on IN cord-286923-o4fj8kx0 37 26 the the DT cord-286923-o4fj8kx0 37 27 unfavorable unfavorable JJ cord-286923-o4fj8kx0 37 28 nature nature NN cord-286923-o4fj8kx0 37 29 of of IN cord-286923-o4fj8kx0 37 30 the the DT cord-286923-o4fj8kx0 37 31 internal internal JJ cord-286923-o4fj8kx0 37 32 milieu milieu NN cord-286923-o4fj8kx0 37 33 of of IN cord-286923-o4fj8kx0 37 34 the the DT cord-286923-o4fj8kx0 37 35 pregnant pregnant JJ cord-286923-o4fj8kx0 37 36 women woman NNS cord-286923-o4fj8kx0 37 37 to to IN cord-286923-o4fj8kx0 37 38 the the DT cord-286923-o4fj8kx0 37 39 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 37 40 related related JJ cord-286923-o4fj8kx0 37 41 inflammatory inflammatory JJ cord-286923-o4fj8kx0 37 42 tissue tissue NN cord-286923-o4fj8kx0 37 43 damage damage NN cord-286923-o4fj8kx0 37 44 and and CC cord-286923-o4fj8kx0 37 45 microthrombotic microthrombotic JJ cord-286923-o4fj8kx0 37 46 events event NNS cord-286923-o4fj8kx0 37 47 and and CC cord-286923-o4fj8kx0 37 48 propose propose VB cord-286923-o4fj8kx0 37 49 potential potential JJ cord-286923-o4fj8kx0 37 50 clinical clinical JJ cord-286923-o4fj8kx0 37 51 trials trial NNS cord-286923-o4fj8kx0 37 52 . . . cord-286923-o4fj8kx0 38 1 The the DT cord-286923-o4fj8kx0 38 2 spectrum spectrum NN cord-286923-o4fj8kx0 38 3 of of IN cord-286923-o4fj8kx0 38 4 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 38 5 is be VBZ cord-286923-o4fj8kx0 38 6 broad broad JJ cord-286923-o4fj8kx0 38 7 and and CC cord-286923-o4fj8kx0 38 8 not not RB cord-286923-o4fj8kx0 38 9 yet yet RB cord-286923-o4fj8kx0 38 10 clearly clearly RB cord-286923-o4fj8kx0 38 11 defined define VBN cord-286923-o4fj8kx0 38 12 . . . cord-286923-o4fj8kx0 39 1 Since since IN cord-286923-o4fj8kx0 39 2 SARS SARS NNP cord-286923-o4fj8kx0 39 3 CoV-2 CoV-2 NNP cord-286923-o4fj8kx0 39 4 can can MD cord-286923-o4fj8kx0 39 5 infect infect VB cord-286923-o4fj8kx0 39 6 a a DT cord-286923-o4fj8kx0 39 7 large large JJ cord-286923-o4fj8kx0 39 8 array array NN cord-286923-o4fj8kx0 39 9 of of IN cord-286923-o4fj8kx0 39 10 respiratory respiratory JJ cord-286923-o4fj8kx0 39 11 and and CC cord-286923-o4fj8kx0 39 12 extra extra JJ cord-286923-o4fj8kx0 39 13 - - JJ cord-286923-o4fj8kx0 39 14 respiratory respiratory JJ cord-286923-o4fj8kx0 39 15 tract tract NN cord-286923-o4fj8kx0 39 16 cells cell NNS cord-286923-o4fj8kx0 39 17 , , , cord-286923-o4fj8kx0 39 18 the the DT cord-286923-o4fj8kx0 39 19 severity severity NN cord-286923-o4fj8kx0 39 20 and and CC cord-286923-o4fj8kx0 39 21 mortality mortality NN cord-286923-o4fj8kx0 39 22 risks risk NNS cord-286923-o4fj8kx0 39 23 were be VBD cord-286923-o4fj8kx0 39 24 reported report VBN cord-286923-o4fj8kx0 39 25 as as IN cord-286923-o4fj8kx0 39 26 being be VBG cord-286923-o4fj8kx0 39 27 predominantly predominantly RB cord-286923-o4fj8kx0 39 28 related relate VBN cord-286923-o4fj8kx0 39 29 to to IN cord-286923-o4fj8kx0 39 30 pneumonia pneumonia NN cord-286923-o4fj8kx0 39 31 , , , cord-286923-o4fj8kx0 39 32 respiratory respiratory JJ cord-286923-o4fj8kx0 39 33 failure failure NN cord-286923-o4fj8kx0 39 34 , , , cord-286923-o4fj8kx0 39 35 acute acute JJ cord-286923-o4fj8kx0 39 36 respiratory respiratory JJ cord-286923-o4fj8kx0 39 37 distress distress NN cord-286923-o4fj8kx0 39 38 syndrome syndrome NN cord-286923-o4fj8kx0 39 39 ( ( -LRB- cord-286923-o4fj8kx0 39 40 ARDS ARDS NNP cord-286923-o4fj8kx0 39 41 ) ) -RRB- cord-286923-o4fj8kx0 39 42 and and CC cord-286923-o4fj8kx0 39 43 sepsis sepsis NN cord-286923-o4fj8kx0 39 44 [ [ -LRB- cord-286923-o4fj8kx0 39 45 23 23 CD cord-286923-o4fj8kx0 39 46 , , , cord-286923-o4fj8kx0 39 47 24 24 CD cord-286923-o4fj8kx0 39 48 ] ] -RRB- cord-286923-o4fj8kx0 39 49 . . . cord-286923-o4fj8kx0 40 1 In in IN cord-286923-o4fj8kx0 40 2 recently recently RB cord-286923-o4fj8kx0 40 3 emerging emerge VBG cord-286923-o4fj8kx0 40 4 reports report NNS cord-286923-o4fj8kx0 40 5 , , , cord-286923-o4fj8kx0 40 6 however however RB cord-286923-o4fj8kx0 40 7 , , , cord-286923-o4fj8kx0 40 8 viral viral JJ cord-286923-o4fj8kx0 40 9 pneumonia pneumonia NN cord-286923-o4fj8kx0 40 10 is be VBZ cord-286923-o4fj8kx0 40 11 highly highly RB cord-286923-o4fj8kx0 40 12 questioned question VBN cord-286923-o4fj8kx0 40 13 ; ; : cord-286923-o4fj8kx0 40 14 rather rather RB cord-286923-o4fj8kx0 40 15 , , , cord-286923-o4fj8kx0 40 16 thrombotic thrombotic JJ cord-286923-o4fj8kx0 40 17 microangiopathy microangiopathy NN cord-286923-o4fj8kx0 40 18 or or CC cord-286923-o4fj8kx0 40 19 atypical atypical JJ cord-286923-o4fj8kx0 40 20 disseminated disseminate VBN cord-286923-o4fj8kx0 40 21 intravascular intravascular JJ cord-286923-o4fj8kx0 40 22 coagulation coagulation NN cord-286923-o4fj8kx0 40 23 ( ( -LRB- cord-286923-o4fj8kx0 40 24 DIC DIC NNP cord-286923-o4fj8kx0 40 25 ) ) -RRB- cord-286923-o4fj8kx0 40 26 with with IN cord-286923-o4fj8kx0 40 27 increased increase VBN cord-286923-o4fj8kx0 40 28 risk risk NN cord-286923-o4fj8kx0 40 29 of of IN cord-286923-o4fj8kx0 40 30 pulmonary pulmonary JJ cord-286923-o4fj8kx0 40 31 vascular vascular JJ cord-286923-o4fj8kx0 40 32 coagulation coagulation NN cord-286923-o4fj8kx0 40 33 and and CC cord-286923-o4fj8kx0 40 34 thromboembolism thromboembolism NN cord-286923-o4fj8kx0 40 35 are be VBP cord-286923-o4fj8kx0 40 36 emphasized emphasize VBN cord-286923-o4fj8kx0 40 37 as as IN cord-286923-o4fj8kx0 40 38 major major JJ cord-286923-o4fj8kx0 40 39 pathological pathological JJ cord-286923-o4fj8kx0 40 40 disorders disorder NNS cord-286923-o4fj8kx0 40 41 associated associate VBN cord-286923-o4fj8kx0 40 42 with with IN cord-286923-o4fj8kx0 40 43 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 40 44 [ [ -LRB- cord-286923-o4fj8kx0 40 45 25 25 CD cord-286923-o4fj8kx0 40 46 ] ] -RRB- cord-286923-o4fj8kx0 41 1 [ [ -LRB- cord-286923-o4fj8kx0 41 2 26 26 CD cord-286923-o4fj8kx0 41 3 ] ] -RRB- cord-286923-o4fj8kx0 41 4 [ [ -LRB- cord-286923-o4fj8kx0 41 5 27 27 CD cord-286923-o4fj8kx0 41 6 ] ] -RRB- cord-286923-o4fj8kx0 41 7 . . . cord-286923-o4fj8kx0 42 1 Unlike unlike IN cord-286923-o4fj8kx0 42 2 other other JJ cord-286923-o4fj8kx0 42 3 causes cause NNS cord-286923-o4fj8kx0 42 4 of of IN cord-286923-o4fj8kx0 42 5 ARDS ARDS NNP cord-286923-o4fj8kx0 42 6 , , , cord-286923-o4fj8kx0 42 7 the the DT cord-286923-o4fj8kx0 42 8 typical typical JJ cord-286923-o4fj8kx0 42 9 features feature NNS cord-286923-o4fj8kx0 42 10 of of IN cord-286923-o4fj8kx0 42 11 ARDS ARDS NNP cord-286923-o4fj8kx0 42 12 with with IN cord-286923-o4fj8kx0 42 13 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 42 14 leading lead VBG cord-286923-o4fj8kx0 42 15 to to IN cord-286923-o4fj8kx0 42 16 respiratory respiratory JJ cord-286923-o4fj8kx0 42 17 failure failure NN cord-286923-o4fj8kx0 42 18 ( ( -LRB- cord-286923-o4fj8kx0 42 19 relatively relatively RB cord-286923-o4fj8kx0 42 20 preserved preserve VBN cord-286923-o4fj8kx0 42 21 lung lung NN cord-286923-o4fj8kx0 42 22 compliance compliance NN cord-286923-o4fj8kx0 42 23 , , , cord-286923-o4fj8kx0 42 24 high high JJ cord-286923-o4fj8kx0 42 25 alveolar alveolar NN cord-286923-o4fj8kx0 42 26 - - HYPH cord-286923-o4fj8kx0 42 27 arterial arterial JJ cord-286923-o4fj8kx0 42 28 oxygen oxygen NN cord-286923-o4fj8kx0 42 29 gradient gradient NN cord-286923-o4fj8kx0 42 30 , , , cord-286923-o4fj8kx0 42 31 and and CC cord-286923-o4fj8kx0 42 32 diffuse diffuse VB cord-286923-o4fj8kx0 42 33 pulmonary pulmonary JJ cord-286923-o4fj8kx0 42 34 microthrombi microthrombi NN cord-286923-o4fj8kx0 42 35 ) ) -RRB- cord-286923-o4fj8kx0 42 36 are be VBP cord-286923-o4fj8kx0 42 37 also also RB cord-286923-o4fj8kx0 42 38 attributed attribute VBN cord-286923-o4fj8kx0 42 39 to to IN cord-286923-o4fj8kx0 42 40 occlusion occlusion NN cord-286923-o4fj8kx0 42 41 of of IN cord-286923-o4fj8kx0 42 42 the the DT cord-286923-o4fj8kx0 42 43 pulmonary pulmonary JJ cord-286923-o4fj8kx0 42 44 microvasculature microvasculature NN cord-286923-o4fj8kx0 42 45 [ [ -LRB- cord-286923-o4fj8kx0 42 46 28 28 CD cord-286923-o4fj8kx0 42 47 ] ] -RRB- cord-286923-o4fj8kx0 42 48 . . . cord-286923-o4fj8kx0 43 1 The the DT cord-286923-o4fj8kx0 43 2 previously previously RB cord-286923-o4fj8kx0 43 3 thought think VBN cord-286923-o4fj8kx0 43 4 interstitial interstitial JJ cord-286923-o4fj8kx0 43 5 pneumonia pneumonia NN cord-286923-o4fj8kx0 43 6 from from IN cord-286923-o4fj8kx0 43 7 lungs lung NNS cord-286923-o4fj8kx0 43 8 X x NN cord-286923-o4fj8kx0 43 9 - - NN cord-286923-o4fj8kx0 43 10 ray ray NN cord-286923-o4fj8kx0 43 11 is be VBZ cord-286923-o4fj8kx0 43 12 reinterpreted reinterpret VBN cord-286923-o4fj8kx0 43 13 as as IN cord-286923-o4fj8kx0 43 14 disseminated disseminate VBN cord-286923-o4fj8kx0 43 15 interstitial interstitial JJ cord-286923-o4fj8kx0 43 16 coagulation coagulation NN cord-286923-o4fj8kx0 43 17 , , , cord-286923-o4fj8kx0 43 18 primed prime VBN cord-286923-o4fj8kx0 43 19 by by IN cord-286923-o4fj8kx0 43 20 inflammation inflammation NN cord-286923-o4fj8kx0 43 21 . . . cord-286923-o4fj8kx0 44 1 Postmortem postmortem JJ cord-286923-o4fj8kx0 44 2 examinations examination NNS cord-286923-o4fj8kx0 44 3 have have VBP cord-286923-o4fj8kx0 44 4 also also RB cord-286923-o4fj8kx0 44 5 indicated indicate VBN cord-286923-o4fj8kx0 44 6 the the DT cord-286923-o4fj8kx0 44 7 diffused diffused JJ cord-286923-o4fj8kx0 44 8 microthrombi microthrombi NN cord-286923-o4fj8kx0 44 9 , , , cord-286923-o4fj8kx0 44 10 which which WDT cord-286923-o4fj8kx0 44 11 are be VBP cord-286923-o4fj8kx0 44 12 more more JJR cord-286923-o4fj8kx0 44 13 of of IN cord-286923-o4fj8kx0 44 14 fibrin fibrin NN cord-286923-o4fj8kx0 44 15 deposits deposit NNS cord-286923-o4fj8kx0 44 16 and and CC cord-286923-o4fj8kx0 44 17 mainly mainly RB cord-286923-o4fj8kx0 44 18 in in IN cord-286923-o4fj8kx0 44 19 the the DT cord-286923-o4fj8kx0 44 20 pulmonary pulmonary JJ cord-286923-o4fj8kx0 44 21 microvascular microvascular JJ cord-286923-o4fj8kx0 44 22 system system NN cord-286923-o4fj8kx0 44 23 . . . cord-286923-o4fj8kx0 45 1 Further further RB cord-286923-o4fj8kx0 45 2 , , , cord-286923-o4fj8kx0 45 3 unlike unlike IN cord-286923-o4fj8kx0 45 4 other other JJ cord-286923-o4fj8kx0 45 5 causes cause NNS cord-286923-o4fj8kx0 45 6 of of IN cord-286923-o4fj8kx0 45 7 DIC DIC NNP cord-286923-o4fj8kx0 45 8 , , , cord-286923-o4fj8kx0 45 9 modest modest JJ cord-286923-o4fj8kx0 45 10 thrombocytopenia thrombocytopenia NN cord-286923-o4fj8kx0 45 11 , , , cord-286923-o4fj8kx0 45 12 little little JJ cord-286923-o4fj8kx0 45 13 change change NN cord-286923-o4fj8kx0 45 14 in in IN cord-286923-o4fj8kx0 45 15 fibrinogen fibrinogen NN cord-286923-o4fj8kx0 45 16 level level NN cord-286923-o4fj8kx0 45 17 , , , cord-286923-o4fj8kx0 45 18 prothrombin prothrombin JJ cord-286923-o4fj8kx0 45 19 time time NN cord-286923-o4fj8kx0 45 20 and and CC cord-286923-o4fj8kx0 45 21 activated activate VBD cord-286923-o4fj8kx0 45 22 partial partial JJ cord-286923-o4fj8kx0 45 23 thromboplastin thromboplastin NNP cord-286923-o4fj8kx0 45 24 time time NN cord-286923-o4fj8kx0 45 25 are be VBP cord-286923-o4fj8kx0 45 26 observed observe VBN cord-286923-o4fj8kx0 45 27 , , , cord-286923-o4fj8kx0 45 28 but but CC cord-286923-o4fj8kx0 45 29 the the DT cord-286923-o4fj8kx0 45 30 d d NN cord-286923-o4fj8kx0 45 31 - - HYPH cord-286923-o4fj8kx0 45 32 dimer dimer NN cord-286923-o4fj8kx0 45 33 is be VBZ cord-286923-o4fj8kx0 45 34 exceptionally exceptionally RB cord-286923-o4fj8kx0 45 35 high high JJ cord-286923-o4fj8kx0 45 36 in in IN cord-286923-o4fj8kx0 45 37 severely severely RB cord-286923-o4fj8kx0 45 38 ill ill JJ cord-286923-o4fj8kx0 45 39 COVID-19 covid-19 CD cord-286923-o4fj8kx0 45 40 patients patient NNS cord-286923-o4fj8kx0 45 41 [ [ -LRB- cord-286923-o4fj8kx0 45 42 23 23 CD cord-286923-o4fj8kx0 45 43 , , , cord-286923-o4fj8kx0 45 44 24 24 CD cord-286923-o4fj8kx0 45 45 , , , cord-286923-o4fj8kx0 45 46 29 29 CD cord-286923-o4fj8kx0 45 47 ] ] -RRB- cord-286923-o4fj8kx0 45 48 . . . cord-286923-o4fj8kx0 46 1 One one CD cord-286923-o4fj8kx0 46 2 more more JJR cord-286923-o4fj8kx0 46 3 , , , cord-286923-o4fj8kx0 46 4 the the DT cord-286923-o4fj8kx0 46 5 absence absence NN cord-286923-o4fj8kx0 46 6 of of IN cord-286923-o4fj8kx0 46 7 hemolysis hemolysis NN cord-286923-o4fj8kx0 46 8 indicators indicator NNS cord-286923-o4fj8kx0 46 9 ( ( -LRB- cord-286923-o4fj8kx0 46 10 like like IN cord-286923-o4fj8kx0 46 11 schistocytes schistocytes NNP cord-286923-o4fj8kx0 46 12 ) ) -RRB- cord-286923-o4fj8kx0 46 13 and and CC cord-286923-o4fj8kx0 46 14 low low JJ cord-286923-o4fj8kx0 46 15 hemorrhagic hemorrhagic JJ cord-286923-o4fj8kx0 46 16 disease disease NN cord-286923-o4fj8kx0 46 17 , , , cord-286923-o4fj8kx0 46 18 even even RB cord-286923-o4fj8kx0 46 19 in in IN cord-286923-o4fj8kx0 46 20 severe severe JJ cord-286923-o4fj8kx0 46 21 cases case NNS cord-286923-o4fj8kx0 46 22 , , , cord-286923-o4fj8kx0 46 23 are be VBP cord-286923-o4fj8kx0 46 24 additional additional JJ cord-286923-o4fj8kx0 46 25 findings finding NNS cord-286923-o4fj8kx0 46 26 for for IN cord-286923-o4fj8kx0 46 27 the the DT cord-286923-o4fj8kx0 46 28 distinct distinct JJ cord-286923-o4fj8kx0 46 29 nature nature NN cord-286923-o4fj8kx0 46 30 of of IN cord-286923-o4fj8kx0 46 31 DIC DIC NNP cord-286923-o4fj8kx0 46 32 and and CC cord-286923-o4fj8kx0 46 33 for for IN cord-286923-o4fj8kx0 46 34 non non JJ cord-286923-o4fj8kx0 46 35 - - JJ cord-286923-o4fj8kx0 46 36 red red JJ cord-286923-o4fj8kx0 46 37 blood blood NN cord-286923-o4fj8kx0 46 38 cells cell NNS cord-286923-o4fj8kx0 46 39 source source NN cord-286923-o4fj8kx0 46 40 of of IN cord-286923-o4fj8kx0 46 41 the the DT cord-286923-o4fj8kx0 46 42 high high JJ cord-286923-o4fj8kx0 46 43 lactate lactate NN cord-286923-o4fj8kx0 46 44 dehydrogenase dehydrogenase NN cord-286923-o4fj8kx0 46 45 ( ( -LRB- cord-286923-o4fj8kx0 46 46 LDH LDH NNP cord-286923-o4fj8kx0 46 47 ) ) -RRB- cord-286923-o4fj8kx0 46 48 in in IN cord-286923-o4fj8kx0 46 49 COVID-19 covid-19 CD cord-286923-o4fj8kx0 46 50 patients patient NNS cord-286923-o4fj8kx0 46 51 [ [ -LRB- cord-286923-o4fj8kx0 46 52 24 24 CD cord-286923-o4fj8kx0 46 53 , , , cord-286923-o4fj8kx0 46 54 27 27 CD cord-286923-o4fj8kx0 46 55 , , , cord-286923-o4fj8kx0 46 56 30 30 CD cord-286923-o4fj8kx0 46 57 ] ] -RRB- cord-286923-o4fj8kx0 46 58 . . . cord-286923-o4fj8kx0 47 1 The the DT cord-286923-o4fj8kx0 47 2 pathological pathological JJ cord-286923-o4fj8kx0 47 3 changes change NNS cord-286923-o4fj8kx0 47 4 in in IN cord-286923-o4fj8kx0 47 5 the the DT cord-286923-o4fj8kx0 47 6 lungs lung NNS cord-286923-o4fj8kx0 47 7 in in IN cord-286923-o4fj8kx0 47 8 a a DT cord-286923-o4fj8kx0 47 9 state state NN cord-286923-o4fj8kx0 47 10 of of IN cord-286923-o4fj8kx0 47 11 ARDS ARDS NNP cord-286923-o4fj8kx0 47 12 , , , cord-286923-o4fj8kx0 47 13 for for IN cord-286923-o4fj8kx0 47 14 instance instance NN cord-286923-o4fj8kx0 47 15 , , , cord-286923-o4fj8kx0 47 16 include include VBP cord-286923-o4fj8kx0 47 17 diffused diffuse VBN cord-286923-o4fj8kx0 47 18 alveolar alveolar JJ cord-286923-o4fj8kx0 47 19 damage damage NN cord-286923-o4fj8kx0 47 20 , , , cord-286923-o4fj8kx0 47 21 hyaline hyaline JJ cord-286923-o4fj8kx0 47 22 membrane membrane NN cord-286923-o4fj8kx0 47 23 formation formation NN cord-286923-o4fj8kx0 47 24 , , , cord-286923-o4fj8kx0 47 25 extensive extensive JJ cord-286923-o4fj8kx0 47 26 microvascular microvascular JJ cord-286923-o4fj8kx0 47 27 thrombosis thrombosis NN cord-286923-o4fj8kx0 47 28 and and CC cord-286923-o4fj8kx0 47 29 interstitial interstitial JJ cord-286923-o4fj8kx0 47 30 edema edema NN cord-286923-o4fj8kx0 47 31 , , , cord-286923-o4fj8kx0 47 32 which which WDT cord-286923-o4fj8kx0 47 33 may may MD cord-286923-o4fj8kx0 47 34 progress progress VB cord-286923-o4fj8kx0 47 35 to to IN cord-286923-o4fj8kx0 47 36 fibrosis fibrosis NN cord-286923-o4fj8kx0 47 37 among among IN cord-286923-o4fj8kx0 47 38 survivors survivor NNS cord-286923-o4fj8kx0 47 39 of of IN cord-286923-o4fj8kx0 47 40 the the DT cord-286923-o4fj8kx0 47 41 acute acute JJ cord-286923-o4fj8kx0 47 42 insult insult NN cord-286923-o4fj8kx0 47 43 [ [ -LRB- cord-286923-o4fj8kx0 47 44 27 27 CD cord-286923-o4fj8kx0 47 45 , , , cord-286923-o4fj8kx0 47 46 31 31 CD cord-286923-o4fj8kx0 47 47 ] ] -RRB- cord-286923-o4fj8kx0 47 48 . . . cord-286923-o4fj8kx0 48 1 As as IN cord-286923-o4fj8kx0 48 2 a a DT cord-286923-o4fj8kx0 48 3 result result NN cord-286923-o4fj8kx0 48 4 , , , cord-286923-o4fj8kx0 48 5 most most JJS cord-286923-o4fj8kx0 48 6 of of IN cord-286923-o4fj8kx0 48 7 the the DT cord-286923-o4fj8kx0 48 8 deaths death NNS cord-286923-o4fj8kx0 48 9 were be VBD cord-286923-o4fj8kx0 48 10 reported report VBN cord-286923-o4fj8kx0 48 11 to to TO cord-286923-o4fj8kx0 48 12 be be VB cord-286923-o4fj8kx0 48 13 due due JJ cord-286923-o4fj8kx0 48 14 to to IN cord-286923-o4fj8kx0 48 15 diffused diffuse VBN cord-286923-o4fj8kx0 48 16 thrombotic thrombotic JJ cord-286923-o4fj8kx0 48 17 microangiopathy microangiopathy NN cord-286923-o4fj8kx0 48 18 and and CC cord-286923-o4fj8kx0 48 19 respiratory respiratory JJ cord-286923-o4fj8kx0 48 20 failure failure NN cord-286923-o4fj8kx0 48 21 [ [ -LRB- cord-286923-o4fj8kx0 48 22 25 25 CD cord-286923-o4fj8kx0 48 23 , , , cord-286923-o4fj8kx0 48 24 32 32 CD cord-286923-o4fj8kx0 48 25 ] ] -RRB- cord-286923-o4fj8kx0 48 26 . . . cord-286923-o4fj8kx0 49 1 The the DT cord-286923-o4fj8kx0 49 2 unregulated unregulated JJ cord-286923-o4fj8kx0 49 3 overproduction overproduction NN cord-286923-o4fj8kx0 49 4 of of IN cord-286923-o4fj8kx0 49 5 proinflammatory proinflammatory JJ cord-286923-o4fj8kx0 49 6 chemokines chemokine NNS cord-286923-o4fj8kx0 49 7 and and CC cord-286923-o4fj8kx0 49 8 cytokines cytokine NNS cord-286923-o4fj8kx0 49 9 ( ( -LRB- cord-286923-o4fj8kx0 49 10 interleukin-6 interleukin-6 NNP cord-286923-o4fj8kx0 49 11 / / SYM cord-286923-o4fj8kx0 49 12 IL-6 IL-6 NNP cord-286923-o4fj8kx0 49 13 and and CC cord-286923-o4fj8kx0 49 14 tumor tumor NN cord-286923-o4fj8kx0 49 15 necrosis necrosis NN cord-286923-o4fj8kx0 49 16 factor factor NN cord-286923-o4fj8kx0 49 17 - - HYPH cord-286923-o4fj8kx0 49 18 alpha alpha NN cord-286923-o4fj8kx0 49 19 / / SYM cord-286923-o4fj8kx0 49 20 TNF TNF NNP cord-286923-o4fj8kx0 49 21 - - HYPH cord-286923-o4fj8kx0 49 22 α α NNP cord-286923-o4fj8kx0 49 23 , , , cord-286923-o4fj8kx0 49 24 in in IN cord-286923-o4fj8kx0 49 25 particular particular JJ cord-286923-o4fj8kx0 49 26 ) ) -RRB- cord-286923-o4fj8kx0 49 27 are be VBP cord-286923-o4fj8kx0 49 28 attributed attribute VBN cord-286923-o4fj8kx0 49 29 to to IN cord-286923-o4fj8kx0 49 30 many many JJ cord-286923-o4fj8kx0 49 31 of of IN cord-286923-o4fj8kx0 49 32 the the DT cord-286923-o4fj8kx0 49 33 severe severe JJ cord-286923-o4fj8kx0 49 34 and and CC cord-286923-o4fj8kx0 49 35 fatal fatal JJ cord-286923-o4fj8kx0 49 36 complications complication NNS cord-286923-o4fj8kx0 49 37 of of IN cord-286923-o4fj8kx0 49 38 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 49 39 ( ( -LRB- cord-286923-o4fj8kx0 49 40 what what WP cord-286923-o4fj8kx0 49 41 is be VBZ cord-286923-o4fj8kx0 49 42 commonly commonly RB cord-286923-o4fj8kx0 49 43 described describe VBN cord-286923-o4fj8kx0 49 44 as as IN cord-286923-o4fj8kx0 49 45 " " `` cord-286923-o4fj8kx0 49 46 cytokine cytokine NN cord-286923-o4fj8kx0 49 47 storm storm NN cord-286923-o4fj8kx0 49 48 " " '' cord-286923-o4fj8kx0 49 49 with with IN cord-286923-o4fj8kx0 49 50 ARDS ARDS NNP cord-286923-o4fj8kx0 49 51 ) ) -RRB- cord-286923-o4fj8kx0 49 52 [ [ -LRB- cord-286923-o4fj8kx0 49 53 33 33 CD cord-286923-o4fj8kx0 49 54 , , , cord-286923-o4fj8kx0 49 55 34 34 CD cord-286923-o4fj8kx0 49 56 ] ] -RRB- cord-286923-o4fj8kx0 49 57 . . . cord-286923-o4fj8kx0 50 1 On on IN cord-286923-o4fj8kx0 50 2 top top NN cord-286923-o4fj8kx0 50 3 of of IN cord-286923-o4fj8kx0 50 4 mediating mediate VBG cord-286923-o4fj8kx0 50 5 inflammation inflammation NN cord-286923-o4fj8kx0 50 6 , , , cord-286923-o4fj8kx0 50 7 the the DT cord-286923-o4fj8kx0 50 8 increased increase VBN cord-286923-o4fj8kx0 50 9 IL-6 IL-6 NNP cord-286923-o4fj8kx0 50 10 level level NN cord-286923-o4fj8kx0 50 11 in in IN cord-286923-o4fj8kx0 50 12 COVID-19 covid-19 JJ cord-286923-o4fj8kx0 50 13 patients patient NNS cord-286923-o4fj8kx0 50 14 is be VBZ cord-286923-o4fj8kx0 50 15 also also RB cord-286923-o4fj8kx0 50 16 attributed attribute VBN cord-286923-o4fj8kx0 50 17 to to IN cord-286923-o4fj8kx0 50 18 initiating initiate VBG cord-286923-o4fj8kx0 50 19 coagulation coagulation NN cord-286923-o4fj8kx0 50 20 activation activation NN cord-286923-o4fj8kx0 50 21 and and CC cord-286923-o4fj8kx0 50 22 thrombin thrombin JJ cord-286923-o4fj8kx0 50 23 generation generation NN cord-286923-o4fj8kx0 50 24 by by IN cord-286923-o4fj8kx0 50 25 inducing induce VBG cord-286923-o4fj8kx0 50 26 tissue tissue NN cord-286923-o4fj8kx0 50 27 factor factor NN cord-286923-o4fj8kx0 50 28 expression expression NN cord-286923-o4fj8kx0 50 29 on on IN cord-286923-o4fj8kx0 50 30 mononuclear mononuclear JJ cord-286923-o4fj8kx0 50 31 cells cell NNS cord-286923-o4fj8kx0 50 32 [ [ -LRB- cord-286923-o4fj8kx0 50 33 27 27 CD cord-286923-o4fj8kx0 50 34 ] ] -RRB- cord-286923-o4fj8kx0 50 35 . . . cord-286923-o4fj8kx0 51 1 As as IN cord-286923-o4fj8kx0 51 2 discussed discuss VBN cord-286923-o4fj8kx0 51 3 hereunder hereunder RB cord-286923-o4fj8kx0 51 4 , , , cord-286923-o4fj8kx0 51 5 accumulating accumulate VBG cord-286923-o4fj8kx0 51 6 evidence evidence NN cord-286923-o4fj8kx0 51 7 from from IN cord-286923-o4fj8kx0 51 8 other other JJ cord-286923-o4fj8kx0 51 9 infections infection NNS cord-286923-o4fj8kx0 51 10 and and CC cord-286923-o4fj8kx0 51 11 autoimmune autoimmune JJ cord-286923-o4fj8kx0 51 12 diseases disease NNS cord-286923-o4fj8kx0 51 13 shows show VBZ cord-286923-o4fj8kx0 51 14 that that IN cord-286923-o4fj8kx0 51 15 immune immune VBP cord-286923-o4fj8kx0 51 16 modulating modulate VBG cord-286923-o4fj8kx0 51 17 hormones hormone NNS cord-286923-o4fj8kx0 51 18 , , , cord-286923-o4fj8kx0 51 19 cytokines cytokine NNS cord-286923-o4fj8kx0 51 20 and and CC cord-286923-o4fj8kx0 51 21 other other JJ cord-286923-o4fj8kx0 51 22 anti anti JJ cord-286923-o4fj8kx0 51 23 - - JJ cord-286923-o4fj8kx0 51 24 inflammatory inflammatory JJ cord-286923-o4fj8kx0 51 25 endogenous endogenous JJ cord-286923-o4fj8kx0 51 26 ligands ligand NNS cord-286923-o4fj8kx0 51 27 are be VBP cord-286923-o4fj8kx0 51 28 determinant determinant JJ cord-286923-o4fj8kx0 51 29 factors factor NNS cord-286923-o4fj8kx0 51 30 in in IN cord-286923-o4fj8kx0 51 31 reducing reduce VBG cord-286923-o4fj8kx0 51 32 the the DT cord-286923-o4fj8kx0 51 33 severity severity NN cord-286923-o4fj8kx0 51 34 of of IN cord-286923-o4fj8kx0 51 35 several several JJ cord-286923-o4fj8kx0 51 36 diseases disease NNS cord-286923-o4fj8kx0 51 37 during during IN cord-286923-o4fj8kx0 51 38 pregnancy pregnancy NN cord-286923-o4fj8kx0 51 39 ; ; : cord-286923-o4fj8kx0 51 40 which which WDT cord-286923-o4fj8kx0 51 41 could could MD cord-286923-o4fj8kx0 51 42 also also RB cord-286923-o4fj8kx0 51 43 be be VB cord-286923-o4fj8kx0 51 44 the the DT cord-286923-o4fj8kx0 51 45 most most RBS cord-286923-o4fj8kx0 51 46 plausible plausible JJ cord-286923-o4fj8kx0 51 47 explanation explanation NN cord-286923-o4fj8kx0 51 48 for for IN cord-286923-o4fj8kx0 51 49 the the DT cord-286923-o4fj8kx0 51 50 less less JJR cord-286923-o4fj8kx0 51 51 severity severity NN cord-286923-o4fj8kx0 51 52 and and CC cord-286923-o4fj8kx0 51 53 mortality mortality NN cord-286923-o4fj8kx0 51 54 of of IN cord-286923-o4fj8kx0 51 55 Covid-19 covid-19 NN cord-286923-o4fj8kx0 51 56 in in IN cord-286923-o4fj8kx0 51 57 pregnant pregnant JJ cord-286923-o4fj8kx0 51 58 women woman NNS cord-286923-o4fj8kx0 51 59 . . . cord-286923-o4fj8kx0 52 1 Pregnancy pregnancy NN cord-286923-o4fj8kx0 52 2 has have VBZ cord-286923-o4fj8kx0 52 3 a a DT cord-286923-o4fj8kx0 52 4 triphasic triphasic JJ cord-286923-o4fj8kx0 52 5 shift shift NN cord-286923-o4fj8kx0 52 6 of of IN cord-286923-o4fj8kx0 52 7 immunological immunological JJ cord-286923-o4fj8kx0 52 8 response response NN cord-286923-o4fj8kx0 52 9 : : : cord-286923-o4fj8kx0 52 10 a a DT cord-286923-o4fj8kx0 52 11 proinflammatory proinflammatory NN cord-286923-o4fj8kx0 52 12 in in IN cord-286923-o4fj8kx0 52 13 early early JJ cord-286923-o4fj8kx0 52 14 stages stage NNS cord-286923-o4fj8kx0 52 15 of of IN cord-286923-o4fj8kx0 52 16 pregnancy pregnancy NN cord-286923-o4fj8kx0 52 17 , , , cord-286923-o4fj8kx0 52 18 anti anti JJ cord-286923-o4fj8kx0 52 19 - - JJ cord-286923-o4fj8kx0 52 20 inflammatory inflammatory JJ cord-286923-o4fj8kx0 52 21 throughout throughout IN cord-286923-o4fj8kx0 52 22 the the DT cord-286923-o4fj8kx0 52 23 rest rest NN cord-286923-o4fj8kx0 52 24 of of IN cord-286923-o4fj8kx0 52 25 pregnancy pregnancy NN cord-286923-o4fj8kx0 52 26 and and CC cord-286923-o4fj8kx0 52 27 proinflammatory proinflammatory JJ cord-286923-o4fj8kx0 52 28 in in IN cord-286923-o4fj8kx0 52 29 the the DT cord-286923-o4fj8kx0 52 30 peripartum peripartum NN cord-286923-o4fj8kx0 52 31 and and CC cord-286923-o4fj8kx0 52 32 postpartum postpartum NN cord-286923-o4fj8kx0 52 33 period period NN cord-286923-o4fj8kx0 52 34 [ [ -LRB- cord-286923-o4fj8kx0 52 35 35 35 CD cord-286923-o4fj8kx0 52 36 ] ] -RRB- cord-286923-o4fj8kx0 52 37 . . . cord-286923-o4fj8kx0 53 1 The the DT cord-286923-o4fj8kx0 53 2 proinflammatory proinflammatory JJ cord-286923-o4fj8kx0 53 3 state state NN cord-286923-o4fj8kx0 53 4 is be VBZ cord-286923-o4fj8kx0 53 5 characterized characterize VBN cord-286923-o4fj8kx0 53 6 by by IN cord-286923-o4fj8kx0 53 7 T t NN cord-286923-o4fj8kx0 53 8 - - HYPH cord-286923-o4fj8kx0 53 9 helper helper NN cord-286923-o4fj8kx0 53 10 / / SYM cord-286923-o4fj8kx0 53 11 Th-1 Th-1 NNP cord-286923-o4fj8kx0 53 12 and and CC cord-286923-o4fj8kx0 53 13 Th-17 Th-17 NNP cord-286923-o4fj8kx0 53 14 immunity immunity NN cord-286923-o4fj8kx0 53 15 dominance dominance NN cord-286923-o4fj8kx0 53 16 ( ( -LRB- cord-286923-o4fj8kx0 53 17 hereafter hereafter RB cord-286923-o4fj8kx0 53 18 Th-1 Th-1 NNP cord-286923-o4fj8kx0 53 19 ) ) -RRB- cord-286923-o4fj8kx0 53 20 , , , cord-286923-o4fj8kx0 53 21 resulting result VBG cord-286923-o4fj8kx0 53 22 in in IN cord-286923-o4fj8kx0 53 23 overproduction overproduction NN cord-286923-o4fj8kx0 53 24 of of IN cord-286923-o4fj8kx0 53 25 proinflammatory proinflammatory JJ cord-286923-o4fj8kx0 53 26 cytokines cytokine NNS cord-286923-o4fj8kx0 53 27 , , , cord-286923-o4fj8kx0 53 28 including include VBG cord-286923-o4fj8kx0 53 29 IL-1β il-1β NN cord-286923-o4fj8kx0 53 30 , , , cord-286923-o4fj8kx0 53 31 IL-6 IL-6 NNP cord-286923-o4fj8kx0 53 32 , , , cord-286923-o4fj8kx0 53 33 Il-8 il-8 FW cord-286923-o4fj8kx0 53 34 , , , cord-286923-o4fj8kx0 53 35 IL-12 IL-12 NNP cord-286923-o4fj8kx0 53 36 , , , cord-286923-o4fj8kx0 53 37 TNF TNF NNP cord-286923-o4fj8kx0 53 38 - - HYPH cord-286923-o4fj8kx0 53 39 α α NNP cord-286923-o4fj8kx0 53 40 , , , cord-286923-o4fj8kx0 53 41 chemotactic chemotactic JJ cord-286923-o4fj8kx0 53 42 cytokines cytokine NNS cord-286923-o4fj8kx0 53 43 ( ( -LRB- cord-286923-o4fj8kx0 53 44 interferon interferon NNP cord-286923-o4fj8kx0 53 45 gamma gamma NN cord-286923-o4fj8kx0 53 46 / / SYM cord-286923-o4fj8kx0 53 47 IFNγ IFNγ NNS cord-286923-o4fj8kx0 53 48 , , , cord-286923-o4fj8kx0 53 49 eotaxin eotaxin NNP cord-286923-o4fj8kx0 53 50 ) ) -RRB- cord-286923-o4fj8kx0 53 51 and and CC cord-286923-o4fj8kx0 53 52 growth growth NN cord-286923-o4fj8kx0 53 53 factors factor NNS cord-286923-o4fj8kx0 53 54 . . . cord-286923-o4fj8kx0 54 1 ( ( -LRB- cord-286923-o4fj8kx0 54 2 IFNγ IFNγ NNS cord-286923-o4fj8kx0 54 3 , , , cord-286923-o4fj8kx0 54 4 IL-1β IL-1β NNP cord-286923-o4fj8kx0 54 5 , , , cord-286923-o4fj8kx0 54 6 IL-6 IL-6 NNP cord-286923-o4fj8kx0 54 7 , , , cord-286923-o4fj8kx0 54 8 and and CC cord-286923-o4fj8kx0 54 9 IL-12 IL-12 NNP cord-286923-o4fj8kx0 54 10 ) ) -RRB- cord-286923-o4fj8kx0 54 11 , , , cord-286923-o4fj8kx0 54 12 which which WDT cord-286923-o4fj8kx0 54 13 were be VBD cord-286923-o4fj8kx0 54 14 attributed attribute VBN cord-286923-o4fj8kx0 54 15 to to IN cord-286923-o4fj8kx0 54 16 the the DT cord-286923-o4fj8kx0 54 17 extensive extensive JJ cord-286923-o4fj8kx0 54 18 lungs lung NNS cord-286923-o4fj8kx0 54 19 damage damage NN cord-286923-o4fj8kx0 54 20 and and CC cord-286923-o4fj8kx0 54 21 high high JJ cord-286923-o4fj8kx0 54 22 mortality mortality NN cord-286923-o4fj8kx0 54 23 [ [ -LRB- cord-286923-o4fj8kx0 54 24 40 40 CD cord-286923-o4fj8kx0 54 25 , , , cord-286923-o4fj8kx0 54 26 41 41 CD cord-286923-o4fj8kx0 54 27 ] ] -RRB- cord-286923-o4fj8kx0 54 28 . . . cord-286923-o4fj8kx0 55 1 It -PRON- PRP cord-286923-o4fj8kx0 55 2 is be VBZ cord-286923-o4fj8kx0 55 3 not not RB cord-286923-o4fj8kx0 55 4 clearly clearly RB cord-286923-o4fj8kx0 55 5 known know VBN cord-286923-o4fj8kx0 55 6 why why WRB cord-286923-o4fj8kx0 55 7 the the DT cord-286923-o4fj8kx0 55 8 Th-2 Th-2 NNP cord-286923-o4fj8kx0 55 9 immunity immunity NN cord-286923-o4fj8kx0 55 10 / / SYM cord-286923-o4fj8kx0 55 11 anti anti JJ cord-286923-o4fj8kx0 55 12 - - JJ cord-286923-o4fj8kx0 55 13 inflammatory inflammatory JJ cord-286923-o4fj8kx0 55 14 cytokines cytokine NNS cord-286923-o4fj8kx0 55 15 were be VBD cord-286923-o4fj8kx0 55 16 equally equally RB cord-286923-o4fj8kx0 55 17 prominent prominent JJ cord-286923-o4fj8kx0 55 18 in in IN cord-286923-o4fj8kx0 55 19 all all DT cord-286923-o4fj8kx0 55 20 investigated investigate VBN cord-286923-o4fj8kx0 55 21 COVID-19 covid-19 CD cord-286923-o4fj8kx0 55 22 cases case NNS cord-286923-o4fj8kx0 55 23 . . . cord-286923-o4fj8kx0 56 1 Although although IN cord-286923-o4fj8kx0 56 2 the the DT cord-286923-o4fj8kx0 56 3 overall overall JJ cord-286923-o4fj8kx0 56 4 condition condition NN cord-286923-o4fj8kx0 56 5 is be VBZ cord-286923-o4fj8kx0 56 6 a a DT cord-286923-o4fj8kx0 56 7 sort sort NN cord-286923-o4fj8kx0 56 8 of of IN cord-286923-o4fj8kx0 56 9 cytokine cytokine NN cord-286923-o4fj8kx0 56 10 release release NN cord-286923-o4fj8kx0 56 11 syndrome syndrome NN cord-286923-o4fj8kx0 56 12 ( ( -LRB- cord-286923-o4fj8kx0 56 13 CRS CRS NNP cord-286923-o4fj8kx0 56 14 ) ) -RRB- cord-286923-o4fj8kx0 56 15 , , . cord-286923-o4fj8kx0 57 1 the the DT cord-286923-o4fj8kx0 57 2 concentration concentration NN cord-286923-o4fj8kx0 57 3 of of IN cord-286923-o4fj8kx0 57 4 proinflammatory proinflammatory JJ cord-286923-o4fj8kx0 57 5 cytokines cytokine NNS cord-286923-o4fj8kx0 57 6 such such JJ cord-286923-o4fj8kx0 57 7 as as IN cord-286923-o4fj8kx0 57 8 IL-6 IL-6 NNP cord-286923-o4fj8kx0 57 9 , , , cord-286923-o4fj8kx0 57 10 TNF TNF NNP cord-286923-o4fj8kx0 57 11 - - HYPH cord-286923-o4fj8kx0 57 12 α α NNP cord-286923-o4fj8kx0 57 13 , , , cord-286923-o4fj8kx0 57 14 IL-1 IL-1 NNP cord-286923-o4fj8kx0 57 15 and and CC cord-286923-o4fj8kx0 57 16 IP-10 IP-10 NNP cord-286923-o4fj8kx0 57 17 was be VBD cord-286923-o4fj8kx0 57 18 much much RB cord-286923-o4fj8kx0 57 19 higher high JJR cord-286923-o4fj8kx0 57 20 among among IN cord-286923-o4fj8kx0 57 21 severe severe JJ cord-286923-o4fj8kx0 57 22 COVID-19 covid-19 JJ cord-286923-o4fj8kx0 57 23 patients patient NNS cord-286923-o4fj8kx0 57 24 [ [ -LRB- cord-286923-o4fj8kx0 57 25 39 39 CD cord-286923-o4fj8kx0 57 26 , , , cord-286923-o4fj8kx0 57 27 42 42 CD cord-286923-o4fj8kx0 57 28 ] ] -RRB- cord-286923-o4fj8kx0 57 29 . . . cord-286923-o4fj8kx0 58 1 IL-6 IL-6 NNP cord-286923-o4fj8kx0 58 2 is be VBZ cord-286923-o4fj8kx0 58 3 thought think VBN cord-286923-o4fj8kx0 58 4 to to TO cord-286923-o4fj8kx0 58 5 be be VB cord-286923-o4fj8kx0 58 6 responsible responsible JJ cord-286923-o4fj8kx0 58 7 for for IN cord-286923-o4fj8kx0 58 8 increased increase VBN cord-286923-o4fj8kx0 58 9 capillary capillary JJ cord-286923-o4fj8kx0 58 10 leakage leakage NN cord-286923-o4fj8kx0 58 11 , , , cord-286923-o4fj8kx0 58 12 activation activation NN cord-286923-o4fj8kx0 58 13 of of IN cord-286923-o4fj8kx0 58 14 complement complement NN cord-286923-o4fj8kx0 58 15 and and CC cord-286923-o4fj8kx0 58 16 the the DT cord-286923-o4fj8kx0 58 17 coagulation coagulation NN cord-286923-o4fj8kx0 58 18 cascade cascade NN cord-286923-o4fj8kx0 58 19 , , , cord-286923-o4fj8kx0 58 20 partly partly RB cord-286923-o4fj8kx0 58 21 leading lead VBG cord-286923-o4fj8kx0 58 22 to to IN cord-286923-o4fj8kx0 58 23 the the DT cord-286923-o4fj8kx0 58 24 development development NN cord-286923-o4fj8kx0 58 25 of of IN cord-286923-o4fj8kx0 58 26 the the DT cord-286923-o4fj8kx0 58 27 atypical atypical JJ cord-286923-o4fj8kx0 58 28 DIC DIC NNP cord-286923-o4fj8kx0 58 29 [ [ -LRB- cord-286923-o4fj8kx0 58 30 43 43 CD cord-286923-o4fj8kx0 58 31 , , , cord-286923-o4fj8kx0 58 32 44 44 CD cord-286923-o4fj8kx0 58 33 ] ] -RRB- cord-286923-o4fj8kx0 58 34 . . . cord-286923-o4fj8kx0 59 1 Therefore therefore RB cord-286923-o4fj8kx0 59 2 , , , cord-286923-o4fj8kx0 59 3 the the DT cord-286923-o4fj8kx0 59 4 parallel parallel JJ cord-286923-o4fj8kx0 59 5 activation activation NN cord-286923-o4fj8kx0 59 6 of of IN cord-286923-o4fj8kx0 59 7 the the DT cord-286923-o4fj8kx0 59 8 Th-1 Th-1 NNP cord-286923-o4fj8kx0 59 9 and and CC cord-286923-o4fj8kx0 59 10 Th-2 Th-2 NNP cord-286923-o4fj8kx0 59 11 immunity immunity NN cord-286923-o4fj8kx0 59 12 in in IN cord-286923-o4fj8kx0 59 13 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 59 14 may may MD cord-286923-o4fj8kx0 59 15 not not RB cord-286923-o4fj8kx0 59 16 lead lead VB cord-286923-o4fj8kx0 59 17 to to IN cord-286923-o4fj8kx0 59 18 a a DT cord-286923-o4fj8kx0 59 19 profound profound JJ cord-286923-o4fj8kx0 59 20 proinflammatory proinflammatory JJ cord-286923-o4fj8kx0 59 21 cytokine cytokine NN cord-286923-o4fj8kx0 59 22 storm storm NN cord-286923-o4fj8kx0 59 23 in in IN cord-286923-o4fj8kx0 59 24 pregnant pregnant JJ cord-286923-o4fj8kx0 59 25 women woman NNS cord-286923-o4fj8kx0 59 26 who who WP cord-286923-o4fj8kx0 59 27 already already RB cord-286923-o4fj8kx0 59 28 have have VBP cord-286923-o4fj8kx0 59 29 dominant dominant JJ cord-286923-o4fj8kx0 59 30 Th-2 Th-2 NNP cord-286923-o4fj8kx0 59 31 immunity immunity NN cord-286923-o4fj8kx0 59 32 . . . cord-286923-o4fj8kx0 60 1 That that DT cord-286923-o4fj8kx0 60 2 is be VBZ cord-286923-o4fj8kx0 60 3 to to TO cord-286923-o4fj8kx0 60 4 mean mean VB cord-286923-o4fj8kx0 60 5 , , , cord-286923-o4fj8kx0 60 6 as as IN cord-286923-o4fj8kx0 60 7 noted note VBN cord-286923-o4fj8kx0 60 8 below below RB cord-286923-o4fj8kx0 60 9 , , , cord-286923-o4fj8kx0 60 10 the the DT cord-286923-o4fj8kx0 60 11 dominated dominate VBN cord-286923-o4fj8kx0 60 12 anti anti JJ cord-286923-o4fj8kx0 60 13 - - JJ cord-286923-o4fj8kx0 60 14 inflammatory inflammatory JJ cord-286923-o4fj8kx0 60 15 state state NN cord-286923-o4fj8kx0 60 16 during during IN cord-286923-o4fj8kx0 60 17 pregnancy pregnancy NN cord-286923-o4fj8kx0 60 18 ( ( -LRB- cord-286923-o4fj8kx0 60 19 the the DT cord-286923-o4fj8kx0 60 20 IL-10 IL-10 NNP cord-286923-o4fj8kx0 60 21 and and CC cord-286923-o4fj8kx0 60 22 placental placental JJ cord-286923-o4fj8kx0 60 23 hormones hormone NNS cord-286923-o4fj8kx0 60 24 , , , cord-286923-o4fj8kx0 60 25 in in IN cord-286923-o4fj8kx0 60 26 particular particular JJ cord-286923-o4fj8kx0 60 27 ) ) -RRB- cord-286923-o4fj8kx0 60 28 may may MD cord-286923-o4fj8kx0 60 29 reduce reduce VB cord-286923-o4fj8kx0 60 30 the the DT cord-286923-o4fj8kx0 60 31 risk risk NN cord-286923-o4fj8kx0 60 32 of of IN cord-286923-o4fj8kx0 60 33 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 60 34 mediated mediate VBN cord-286923-o4fj8kx0 60 35 cytokine cytokine NN cord-286923-o4fj8kx0 60 36 storm storm NN cord-286923-o4fj8kx0 60 37 and and CC cord-286923-o4fj8kx0 60 38 thrombotic thrombotic JJ cord-286923-o4fj8kx0 60 39 microangiopathy microangiopathy NNP cord-286923-o4fj8kx0 60 40 . . . cord-286923-o4fj8kx0 61 1 The the DT cord-286923-o4fj8kx0 61 2 markedly markedly RB cord-286923-o4fj8kx0 61 3 elevated elevate VBN cord-286923-o4fj8kx0 61 4 IL-10 IL-10 NNP cord-286923-o4fj8kx0 61 5 level level NN cord-286923-o4fj8kx0 61 6 , , , cord-286923-o4fj8kx0 61 7 starting start VBG cord-286923-o4fj8kx0 61 8 from from IN cord-286923-o4fj8kx0 61 9 early early JJ cord-286923-o4fj8kx0 61 10 pregnancy pregnancy NN cord-286923-o4fj8kx0 61 11 and and CC cord-286923-o4fj8kx0 61 12 throughout throughout IN cord-286923-o4fj8kx0 61 13 pregnancy pregnancy NN cord-286923-o4fj8kx0 61 14 , , , cord-286923-o4fj8kx0 61 15 is be VBZ cord-286923-o4fj8kx0 61 16 a a DT cord-286923-o4fj8kx0 61 17 unique unique JJ cord-286923-o4fj8kx0 61 18 characteristic characteristic NN cord-286923-o4fj8kx0 61 19 of of IN cord-286923-o4fj8kx0 61 20 normal normal JJ cord-286923-o4fj8kx0 61 21 pregnancy pregnancy NN cord-286923-o4fj8kx0 61 22 . . . cord-286923-o4fj8kx0 62 1 The the DT cord-286923-o4fj8kx0 62 2 multitude multitude JJ cord-286923-o4fj8kx0 62 3 sources source NNS cord-286923-o4fj8kx0 62 4 of of IN cord-286923-o4fj8kx0 62 5 IL-10 IL-10 NNP cord-286923-o4fj8kx0 62 6 , , , cord-286923-o4fj8kx0 62 7 particularly particularly RB cord-286923-o4fj8kx0 62 8 at at IN cord-286923-o4fj8kx0 62 9 the the DT cord-286923-o4fj8kx0 62 10 placental placental JJ cord-286923-o4fj8kx0 62 11 - - HYPH cord-286923-o4fj8kx0 62 12 decidual decidual NN cord-286923-o4fj8kx0 62 13 interface interface NN cord-286923-o4fj8kx0 62 14 ( ( -LRB- cord-286923-o4fj8kx0 62 15 trophoblasts trophoblast NNS cord-286923-o4fj8kx0 62 16 , , , cord-286923-o4fj8kx0 62 17 uterine uterine JJ cord-286923-o4fj8kx0 62 18 natural natural JJ cord-286923-o4fj8kx0 62 19 killer killer NN cord-286923-o4fj8kx0 62 20 cells cell NNS cord-286923-o4fj8kx0 62 21 , , , cord-286923-o4fj8kx0 62 22 monocytes monocyte NNS cord-286923-o4fj8kx0 62 23 , , , cord-286923-o4fj8kx0 62 24 and and CC cord-286923-o4fj8kx0 62 25 Tg Tg NNP cord-286923-o4fj8kx0 62 26 cells cell NNS cord-286923-o4fj8kx0 62 27 ) ) -RRB- cord-286923-o4fj8kx0 62 28 , , , cord-286923-o4fj8kx0 62 29 make make VB cord-286923-o4fj8kx0 62 30 it -PRON- PRP cord-286923-o4fj8kx0 62 31 to to TO cord-286923-o4fj8kx0 62 32 be be VB cord-286923-o4fj8kx0 62 33 available available JJ cord-286923-o4fj8kx0 62 34 in in IN cord-286923-o4fj8kx0 62 35 abundant abundant JJ cord-286923-o4fj8kx0 62 36 amount amount NN cord-286923-o4fj8kx0 62 37 [ [ -LRB- cord-286923-o4fj8kx0 62 38 45 45 CD cord-286923-o4fj8kx0 62 39 ] ] -RRB- cord-286923-o4fj8kx0 62 40 , , , cord-286923-o4fj8kx0 62 41 which which WDT cord-286923-o4fj8kx0 62 42 is be VBZ cord-286923-o4fj8kx0 62 43 a a DT cord-286923-o4fj8kx0 62 44 benefit benefit NN cord-286923-o4fj8kx0 62 45 for for IN cord-286923-o4fj8kx0 62 46 the the DT cord-286923-o4fj8kx0 62 47 dominance dominance NN cord-286923-o4fj8kx0 62 48 of of IN cord-286923-o4fj8kx0 62 49 the the DT cord-286923-o4fj8kx0 62 50 anti anti JJ cord-286923-o4fj8kx0 62 51 - - JJ cord-286923-o4fj8kx0 62 52 inflammatory inflammatory JJ cord-286923-o4fj8kx0 62 53 state state NN cord-286923-o4fj8kx0 62 54 of of IN cord-286923-o4fj8kx0 62 55 pregnancy pregnancy NN cord-286923-o4fj8kx0 62 56 . . . cord-286923-o4fj8kx0 63 1 The the DT cord-286923-o4fj8kx0 63 2 implication implication NN cord-286923-o4fj8kx0 63 3 is be VBZ cord-286923-o4fj8kx0 63 4 that that IN cord-286923-o4fj8kx0 63 5 the the DT cord-286923-o4fj8kx0 63 6 antiinflammatory antiinflammatory JJ cord-286923-o4fj8kx0 63 7 and and CC cord-286923-o4fj8kx0 63 8 antifibrotic antifibrotic JJ cord-286923-o4fj8kx0 63 9 actions action NNS cord-286923-o4fj8kx0 63 10 of of IN cord-286923-o4fj8kx0 63 11 IL-10 IL-10 NNP cord-286923-o4fj8kx0 63 12 in in IN cord-286923-o4fj8kx0 63 13 the the DT cord-286923-o4fj8kx0 63 14 lungs lung NNS cord-286923-o4fj8kx0 63 15 and and CC cord-286923-o4fj8kx0 63 16 other other JJ cord-286923-o4fj8kx0 63 17 tissues tissue NNS cord-286923-o4fj8kx0 63 18 by by IN cord-286923-o4fj8kx0 63 19 suppressing suppress VBG cord-286923-o4fj8kx0 63 20 the the DT cord-286923-o4fj8kx0 63 21 Th-1 Th-1 NNP cord-286923-o4fj8kx0 63 22 immunity immunity NN cord-286923-o4fj8kx0 63 23 [ [ -LRB- cord-286923-o4fj8kx0 63 24 46 46 CD cord-286923-o4fj8kx0 63 25 ] ] -RRB- cord-286923-o4fj8kx0 63 26 is be VBZ cord-286923-o4fj8kx0 63 27 probably probably RB cord-286923-o4fj8kx0 63 28 protective protective JJ cord-286923-o4fj8kx0 63 29 from from IN cord-286923-o4fj8kx0 63 30 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 63 31 . . . cord-286923-o4fj8kx0 64 1 Interestingly interestingly RB cord-286923-o4fj8kx0 64 2 , , , cord-286923-o4fj8kx0 64 3 while while IN cord-286923-o4fj8kx0 64 4 inhibiting inhibit VBG cord-286923-o4fj8kx0 64 5 the the DT cord-286923-o4fj8kx0 64 6 Th-1 Th-1 NNP cord-286923-o4fj8kx0 64 7 cells cell NNS cord-286923-o4fj8kx0 64 8 , , , cord-286923-o4fj8kx0 64 9 IL-10 IL-10 NNP cord-286923-o4fj8kx0 64 10 enhances enhance VBZ cord-286923-o4fj8kx0 64 11 B b NN cord-286923-o4fj8kx0 64 12 cells cell NNS cord-286923-o4fj8kx0 64 13 survival survival NN cord-286923-o4fj8kx0 64 14 and and CC cord-286923-o4fj8kx0 64 15 antibody antibody NN cord-286923-o4fj8kx0 64 16 production production NN cord-286923-o4fj8kx0 64 17 , , , cord-286923-o4fj8kx0 64 18 which which WDT cord-286923-o4fj8kx0 64 19 is be VBZ cord-286923-o4fj8kx0 64 20 beneficiary beneficiary NN cord-286923-o4fj8kx0 64 21 to to TO cord-286923-o4fj8kx0 64 22 balance balance VB cord-286923-o4fj8kx0 64 23 the the DT cord-286923-o4fj8kx0 64 24 immune immune JJ cord-286923-o4fj8kx0 64 25 suppression suppression NN cord-286923-o4fj8kx0 64 26 and and CC cord-286923-o4fj8kx0 64 27 induction induction NN cord-286923-o4fj8kx0 64 28 [ [ -LRB- cord-286923-o4fj8kx0 64 29 47 47 CD cord-286923-o4fj8kx0 64 30 ] ] -RRB- cord-286923-o4fj8kx0 64 31 . . . cord-286923-o4fj8kx0 65 1 Generally generally RB cord-286923-o4fj8kx0 65 2 , , , cord-286923-o4fj8kx0 65 3 there there EX cord-286923-o4fj8kx0 65 4 is be VBZ cord-286923-o4fj8kx0 65 5 a a DT cord-286923-o4fj8kx0 65 6 large large JJ cord-286923-o4fj8kx0 65 7 body body NN cord-286923-o4fj8kx0 65 8 of of IN cord-286923-o4fj8kx0 65 9 evidence evidence NN cord-286923-o4fj8kx0 65 10 which which WDT cord-286923-o4fj8kx0 65 11 showed show VBD cord-286923-o4fj8kx0 65 12 that that IN cord-286923-o4fj8kx0 65 13 IL-10 IL-10 NNP cord-286923-o4fj8kx0 65 14 is be VBZ cord-286923-o4fj8kx0 65 15 a a DT cord-286923-o4fj8kx0 65 16 key key JJ cord-286923-o4fj8kx0 65 17 cytokine cytokine NN cord-286923-o4fj8kx0 65 18 with with IN cord-286923-o4fj8kx0 65 19 multifaceted multifaceted JJ cord-286923-o4fj8kx0 65 20 actions action NNS cord-286923-o4fj8kx0 65 21 during during IN cord-286923-o4fj8kx0 65 22 healthy healthy JJ cord-286923-o4fj8kx0 65 23 pregnancy pregnancy NN cord-286923-o4fj8kx0 65 24 . . . cord-286923-o4fj8kx0 66 1 The the DT cord-286923-o4fj8kx0 66 2 significantly significantly RB cord-286923-o4fj8kx0 66 3 lower low JJR cord-286923-o4fj8kx0 66 4 level level NN cord-286923-o4fj8kx0 66 5 of of IN cord-286923-o4fj8kx0 66 6 IL-10 IL-10 NNP cord-286923-o4fj8kx0 66 7 in in IN cord-286923-o4fj8kx0 66 8 the the DT cord-286923-o4fj8kx0 66 9 placenta placenta NN cord-286923-o4fj8kx0 66 10 and and CC cord-286923-o4fj8kx0 66 11 decidua decidua NN cord-286923-o4fj8kx0 66 12 of of IN cord-286923-o4fj8kx0 66 13 women woman NNS cord-286923-o4fj8kx0 66 14 with with IN cord-286923-o4fj8kx0 66 15 missed miss VBN cord-286923-o4fj8kx0 66 16 abortion abortion NN cord-286923-o4fj8kx0 66 17 , , , cord-286923-o4fj8kx0 66 18 recurrent recurrent JJ cord-286923-o4fj8kx0 66 19 spontaneous spontaneous JJ cord-286923-o4fj8kx0 66 20 abortion abortion NN cord-286923-o4fj8kx0 66 21 , , , cord-286923-o4fj8kx0 66 22 preterm preterm NNS cord-286923-o4fj8kx0 66 23 birth birth NN cord-286923-o4fj8kx0 66 24 , , , cord-286923-o4fj8kx0 66 25 preeclampsia preeclampsia NN cord-286923-o4fj8kx0 66 26 , , , cord-286923-o4fj8kx0 66 27 and and CC cord-286923-o4fj8kx0 66 28 fetal fetal JJ cord-286923-o4fj8kx0 66 29 growth growth NN cord-286923-o4fj8kx0 66 30 restriction restriction NN cord-286923-o4fj8kx0 66 31 [ [ -LRB- cord-286923-o4fj8kx0 66 32 46 46 CD cord-286923-o4fj8kx0 66 33 ] ] -RRB- cord-286923-o4fj8kx0 66 34 may may MD cord-286923-o4fj8kx0 66 35 also also RB cord-286923-o4fj8kx0 66 36 suggest suggest VB cord-286923-o4fj8kx0 66 37 how how WRB cord-286923-o4fj8kx0 66 38 potent potent JJ cord-286923-o4fj8kx0 66 39 it -PRON- PRP cord-286923-o4fj8kx0 66 40 is be VBZ cord-286923-o4fj8kx0 66 41 in in IN cord-286923-o4fj8kx0 66 42 protecting protect VBG cord-286923-o4fj8kx0 66 43 the the DT cord-286923-o4fj8kx0 66 44 normal normal JJ cord-286923-o4fj8kx0 66 45 progress progress NN cord-286923-o4fj8kx0 66 46 of of IN cord-286923-o4fj8kx0 66 47 pregnancy pregnancy NN cord-286923-o4fj8kx0 66 48 unless unless IN cord-286923-o4fj8kx0 66 49 the the DT cord-286923-o4fj8kx0 66 50 other other JJ cord-286923-o4fj8kx0 66 51 way way NN cord-286923-o4fj8kx0 66 52 round round RB cord-286923-o4fj8kx0 66 53 is be VBZ cord-286923-o4fj8kx0 66 54 considered consider VBN cord-286923-o4fj8kx0 66 55 ( ( -LRB- cord-286923-o4fj8kx0 66 56 some some DT cord-286923-o4fj8kx0 66 57 other other JJ cord-286923-o4fj8kx0 66 58 pathology pathology NN cord-286923-o4fj8kx0 66 59 compromising compromise VBG cord-286923-o4fj8kx0 66 60 its -PRON- PRP$ cord-286923-o4fj8kx0 66 61 secretion secretion NN cord-286923-o4fj8kx0 66 62 ) ) -RRB- cord-286923-o4fj8kx0 66 63 . . . cord-286923-o4fj8kx0 67 1 Several several JJ cord-286923-o4fj8kx0 67 2 studies study NNS cord-286923-o4fj8kx0 67 3 have have VBP cord-286923-o4fj8kx0 67 4 also also RB cord-286923-o4fj8kx0 67 5 indicated indicate VBN cord-286923-o4fj8kx0 67 6 the the DT cord-286923-o4fj8kx0 67 7 _SP cord-286923-o4fj8kx0 67 8 The the DT cord-286923-o4fj8kx0 67 9 deterioration deterioration NN cord-286923-o4fj8kx0 67 10 of of IN cord-286923-o4fj8kx0 67 11 COVID-19 covid-19 JJ cord-286923-o4fj8kx0 67 12 patients patient NNS cord-286923-o4fj8kx0 67 13 is be VBZ cord-286923-o4fj8kx0 67 14 mainly mainly RB cord-286923-o4fj8kx0 67 15 due due JJ cord-286923-o4fj8kx0 67 16 to to IN cord-286923-o4fj8kx0 67 17 overproduction overproduction NN cord-286923-o4fj8kx0 67 18 of of IN cord-286923-o4fj8kx0 67 19 proinflammatory proinflammatory JJ cord-286923-o4fj8kx0 67 20 cytokines cytokine NNS cord-286923-o4fj8kx0 67 21 and and CC cord-286923-o4fj8kx0 67 22 activation activation NN cord-286923-o4fj8kx0 67 23 of of IN cord-286923-o4fj8kx0 67 24 the the DT cord-286923-o4fj8kx0 67 25 coagulation coagulation NN cord-286923-o4fj8kx0 67 26 pathway pathway NN cord-286923-o4fj8kx0 67 27 partly partly RB cord-286923-o4fj8kx0 67 28 via via IN cord-286923-o4fj8kx0 67 29 protease protease NN cord-286923-o4fj8kx0 67 30 activated activate VBN cord-286923-o4fj8kx0 67 31 receptors receptor NNS cord-286923-o4fj8kx0 67 32 ( ( -LRB- cord-286923-o4fj8kx0 67 33 principally principally RB cord-286923-o4fj8kx0 67 34 PAR-1 PAR-1 NNP cord-286923-o4fj8kx0 67 35 ) ) -RRB- cord-286923-o4fj8kx0 67 36 and and CC cord-286923-o4fj8kx0 67 37 IL-6 IL-6 NNP cord-286923-o4fj8kx0 67 38 [ [ -LRB- cord-286923-o4fj8kx0 67 39 51 51 CD cord-286923-o4fj8kx0 67 40 , , , cord-286923-o4fj8kx0 67 41 52 52 CD cord-286923-o4fj8kx0 67 42 ] ] -RRB- cord-286923-o4fj8kx0 67 43 . . . cord-286923-o4fj8kx0 68 1 This this DT cord-286923-o4fj8kx0 68 2 will will MD cord-286923-o4fj8kx0 68 3 lead lead VB cord-286923-o4fj8kx0 68 4 to to IN cord-286923-o4fj8kx0 68 5 exaggerated exaggerated JJ cord-286923-o4fj8kx0 68 6 inflammatory inflammatory JJ cord-286923-o4fj8kx0 68 7 response response NN cord-286923-o4fj8kx0 68 8 and and CC cord-286923-o4fj8kx0 68 9 procoagulant procoagulant NN cord-286923-o4fj8kx0 68 10 - - HYPH cord-286923-o4fj8kx0 68 11 anticoagulant anticoagulant JJ cord-286923-o4fj8kx0 68 12 imbalance imbalance NN cord-286923-o4fj8kx0 68 13 , , , cord-286923-o4fj8kx0 68 14 which which WDT cord-286923-o4fj8kx0 68 15 in in IN cord-286923-o4fj8kx0 68 16 turn turn NN cord-286923-o4fj8kx0 68 17 results result VBZ cord-286923-o4fj8kx0 68 18 in in IN cord-286923-o4fj8kx0 68 19 a a DT cord-286923-o4fj8kx0 68 20 cascade cascade NN cord-286923-o4fj8kx0 68 21 of of IN cord-286923-o4fj8kx0 68 22 catastrophic catastrophic JJ cord-286923-o4fj8kx0 68 23 events event NNS cord-286923-o4fj8kx0 68 24 ( ( -LRB- cord-286923-o4fj8kx0 68 25 extensive extensive JJ cord-286923-o4fj8kx0 68 26 tissue tissue NN cord-286923-o4fj8kx0 68 27 damage damage NN cord-286923-o4fj8kx0 68 28 , , , cord-286923-o4fj8kx0 68 29 release release NN cord-286923-o4fj8kx0 68 30 of of IN cord-286923-o4fj8kx0 68 31 excess excess JJ cord-286923-o4fj8kx0 68 32 tissue tissue NN cord-286923-o4fj8kx0 68 33 thromboplastin thromboplastin NNS cord-286923-o4fj8kx0 68 34 , , , cord-286923-o4fj8kx0 68 35 diffused diffuse VBN cord-286923-o4fj8kx0 68 36 microthrombosis microthrombosis NN cord-286923-o4fj8kx0 68 37 , , , cord-286923-o4fj8kx0 68 38 DIC DIC NNP cord-286923-o4fj8kx0 68 39 , , , cord-286923-o4fj8kx0 68 40 and and CC cord-286923-o4fj8kx0 68 41 multiorgan multiorgan NNP cord-286923-o4fj8kx0 68 42 failure failure NN cord-286923-o4fj8kx0 68 43 ) ) -RRB- cord-286923-o4fj8kx0 68 44 . . . cord-286923-o4fj8kx0 69 1 In in IN cord-286923-o4fj8kx0 69 2 pregnant pregnant JJ cord-286923-o4fj8kx0 69 3 women woman NNS cord-286923-o4fj8kx0 69 4 , , , cord-286923-o4fj8kx0 69 5 however however RB cord-286923-o4fj8kx0 69 6 , , , cord-286923-o4fj8kx0 69 7 this this DT cord-286923-o4fj8kx0 69 8 is be VBZ cord-286923-o4fj8kx0 69 9 not not RB cord-286923-o4fj8kx0 69 10 the the DT cord-286923-o4fj8kx0 69 11 case case NN cord-286923-o4fj8kx0 69 12 probably probably RB cord-286923-o4fj8kx0 69 13 partly partly RB cord-286923-o4fj8kx0 69 14 because because IN cord-286923-o4fj8kx0 69 15 of of IN cord-286923-o4fj8kx0 69 16 the the DT cord-286923-o4fj8kx0 69 17 physiological physiological JJ cord-286923-o4fj8kx0 69 18 changes change NNS cord-286923-o4fj8kx0 69 19 in in IN cord-286923-o4fj8kx0 69 20 the the DT cord-286923-o4fj8kx0 69 21 hematological hematological JJ cord-286923-o4fj8kx0 69 22 system system NN cord-286923-o4fj8kx0 69 23 . . . cord-286923-o4fj8kx0 70 1 Among among IN cord-286923-o4fj8kx0 70 2 multiple multiple JJ cord-286923-o4fj8kx0 70 3 actions action NNS cord-286923-o4fj8kx0 70 4 of of IN cord-286923-o4fj8kx0 70 5 thrombin thrombin NN cord-286923-o4fj8kx0 70 6 , , , cord-286923-o4fj8kx0 70 7 there there EX cord-286923-o4fj8kx0 70 8 is be VBZ cord-286923-o4fj8kx0 70 9 a a DT cord-286923-o4fj8kx0 70 10 large large JJ cord-286923-o4fj8kx0 70 11 body body NN cord-286923-o4fj8kx0 70 12 of of IN cord-286923-o4fj8kx0 70 13 data datum NNS cord-286923-o4fj8kx0 70 14 that that WDT cord-286923-o4fj8kx0 70 15 has have VBZ cord-286923-o4fj8kx0 70 16 shown show VBN cord-286923-o4fj8kx0 70 17 its -PRON- PRP$ cord-286923-o4fj8kx0 70 18 involvement involvement NN cord-286923-o4fj8kx0 70 19 in in IN cord-286923-o4fj8kx0 70 20 the the DT cord-286923-o4fj8kx0 70 21 induction induction NN cord-286923-o4fj8kx0 70 22 of of IN cord-286923-o4fj8kx0 70 23 systemic systemic JJ cord-286923-o4fj8kx0 70 24 intravascular intravascular JJ cord-286923-o4fj8kx0 70 25 inflammation inflammation NN cord-286923-o4fj8kx0 70 26 mediated mediate VBN cord-286923-o4fj8kx0 70 27 through through IN cord-286923-o4fj8kx0 70 28 PAR-1 PAR-1 NNP cord-286923-o4fj8kx0 70 29 ( ( -LRB- cord-286923-o4fj8kx0 70 30 by by IN cord-286923-o4fj8kx0 70 31 increasing increase VBG cord-286923-o4fj8kx0 70 32 the the DT cord-286923-o4fj8kx0 70 33 release release NN cord-286923-o4fj8kx0 70 34 of of IN cord-286923-o4fj8kx0 70 35 IL-1β IL-1β NNP cord-286923-o4fj8kx0 70 36 , , , cord-286923-o4fj8kx0 70 37 IL-6 IL-6 NNP cord-286923-o4fj8kx0 70 38 and and CC cord-286923-o4fj8kx0 70 39 IL-8 IL-8 NNP cord-286923-o4fj8kx0 70 40 , , , cord-286923-o4fj8kx0 70 41 activation activation NN cord-286923-o4fj8kx0 70 42 of of IN cord-286923-o4fj8kx0 70 43 endothelial endothelial JJ cord-286923-o4fj8kx0 70 44 and and CC cord-286923-o4fj8kx0 70 45 mast mast NN cord-286923-o4fj8kx0 70 46 cells cell NNS cord-286923-o4fj8kx0 70 47 , , , cord-286923-o4fj8kx0 70 48 and and CC cord-286923-o4fj8kx0 70 49 recruitment recruitment NN cord-286923-o4fj8kx0 70 50 of of IN cord-286923-o4fj8kx0 70 51 monocytes monocyte NNS cord-286923-o4fj8kx0 70 52 ) ) -RRB- cord-286923-o4fj8kx0 70 53 , , , cord-286923-o4fj8kx0 70 54 which which WDT cord-286923-o4fj8kx0 70 55 is be VBZ cord-286923-o4fj8kx0 70 56 also also RB cord-286923-o4fj8kx0 70 57 ascribed ascribe VBN cord-286923-o4fj8kx0 70 58 for for IN cord-286923-o4fj8kx0 70 59 the the DT cord-286923-o4fj8kx0 70 60 pathogenesis pathogenesis NN cord-286923-o4fj8kx0 70 61 of of IN cord-286923-o4fj8kx0 70 62 preeclampsia preeclampsia NN cord-286923-o4fj8kx0 70 63 [ [ -LRB- cord-286923-o4fj8kx0 70 64 53 53 CD cord-286923-o4fj8kx0 70 65 ] ] -RRB- cord-286923-o4fj8kx0 70 66 [ [ -LRB- cord-286923-o4fj8kx0 70 67 54 54 CD cord-286923-o4fj8kx0 70 68 ] ] -RRB- cord-286923-o4fj8kx0 70 69 [ [ -LRB- cord-286923-o4fj8kx0 70 70 55 55 CD cord-286923-o4fj8kx0 70 71 ] ] -RRB- cord-286923-o4fj8kx0 70 72 . . . cord-286923-o4fj8kx0 71 1 In in IN cord-286923-o4fj8kx0 71 2 non non JJ cord-286923-o4fj8kx0 71 3 - - JJ cord-286923-o4fj8kx0 71 4 pregnant pregnant JJ cord-286923-o4fj8kx0 71 5 COVID-19 covid-19 JJ cord-286923-o4fj8kx0 71 6 patients patient NNS cord-286923-o4fj8kx0 71 7 , , , cord-286923-o4fj8kx0 71 8 the the DT cord-286923-o4fj8kx0 71 9 diffused diffuse VBN cord-286923-o4fj8kx0 71 10 inflammatory inflammatory JJ cord-286923-o4fj8kx0 71 11 reaction reaction NN cord-286923-o4fj8kx0 71 12 already already RB cord-286923-o4fj8kx0 71 13 induced induce VBN cord-286923-o4fj8kx0 71 14 by by IN cord-286923-o4fj8kx0 71 15 the the DT cord-286923-o4fj8kx0 71 16 proinflammatory proinflammatory JJ cord-286923-o4fj8kx0 71 17 cytokines cytokine NNS cord-286923-o4fj8kx0 71 18 is be VBZ cord-286923-o4fj8kx0 71 19 a a DT cord-286923-o4fj8kx0 71 20 triggering trigger VBG cord-286923-o4fj8kx0 71 21 factor factor NN cord-286923-o4fj8kx0 71 22 in in IN cord-286923-o4fj8kx0 71 23 the the DT cord-286923-o4fj8kx0 71 24 over over JJ cord-286923-o4fj8kx0 71 25 activation activation NN cord-286923-o4fj8kx0 71 26 of of IN cord-286923-o4fj8kx0 71 27 PAR-1thrombin PAR-1thrombin NNP cord-286923-o4fj8kx0 71 28 induced induce VBD cord-286923-o4fj8kx0 71 29 inflammation inflammation NN cord-286923-o4fj8kx0 71 30 and and CC cord-286923-o4fj8kx0 71 31 defective defective JJ cord-286923-o4fj8kx0 71 32 anticoagulant anticoagulant JJ cord-286923-o4fj8kx0 71 33 system system NN cord-286923-o4fj8kx0 71 34 ( ( -LRB- cord-286923-o4fj8kx0 71 35 ineffective ineffective JJ cord-286923-o4fj8kx0 71 36 J J NNP cord-286923-o4fj8kx0 71 37 o o NN cord-286923-o4fj8kx0 71 38 u u NN cord-286923-o4fj8kx0 71 39 r r NN cord-286923-o4fj8kx0 71 40 n n NN cord-286923-o4fj8kx0 71 41 a a DT cord-286923-o4fj8kx0 71 42 l l NN cord-286923-o4fj8kx0 71 43 P p NN cord-286923-o4fj8kx0 71 44 r r NN cord-286923-o4fj8kx0 71 45 e e NN cord-286923-o4fj8kx0 72 1 -p -p NNP cord-286923-o4fj8kx0 72 2 r r NN cord-286923-o4fj8kx0 72 3 o o NN cord-286923-o4fj8kx0 72 4 o o NN cord-286923-o4fj8kx0 72 5 f f NN cord-286923-o4fj8kx0 73 1 antithrombin antithrombin NNP cord-286923-o4fj8kx0 73 2 III III NNP cord-286923-o4fj8kx0 73 3 , , , cord-286923-o4fj8kx0 73 4 tissue tissue NN cord-286923-o4fj8kx0 73 5 factor factor NN cord-286923-o4fj8kx0 73 6 pathway pathway NN cord-286923-o4fj8kx0 73 7 inhibitor inhibitor NN cord-286923-o4fj8kx0 73 8 , , , cord-286923-o4fj8kx0 73 9 and and CC cord-286923-o4fj8kx0 73 10 the the DT cord-286923-o4fj8kx0 73 11 protein protein NN cord-286923-o4fj8kx0 73 12 C C NNP cord-286923-o4fj8kx0 73 13 system system NN cord-286923-o4fj8kx0 73 14 ) ) -RRB- cord-286923-o4fj8kx0 74 1 as as RB cord-286923-o4fj8kx0 74 2 already already RB cord-286923-o4fj8kx0 74 3 noted note VBN cord-286923-o4fj8kx0 74 4 in in IN cord-286923-o4fj8kx0 74 5 other other JJ cord-286923-o4fj8kx0 74 6 fibroproliferative fibroproliferative JJ cord-286923-o4fj8kx0 74 7 inflammatory inflammatory JJ cord-286923-o4fj8kx0 74 8 lung lung NN cord-286923-o4fj8kx0 74 9 disease disease NN cord-286923-o4fj8kx0 74 10 [ [ -LRB- cord-286923-o4fj8kx0 74 11 51 51 CD cord-286923-o4fj8kx0 74 12 ] ] -RRB- cord-286923-o4fj8kx0 74 13 . . . cord-286923-o4fj8kx0 75 1 Interestingly interestingly RB cord-286923-o4fj8kx0 75 2 , , , cord-286923-o4fj8kx0 75 3 in in IN cord-286923-o4fj8kx0 75 4 normal normal JJ cord-286923-o4fj8kx0 75 5 pregnancy pregnancy NN cord-286923-o4fj8kx0 75 6 , , , cord-286923-o4fj8kx0 75 7 however however RB cord-286923-o4fj8kx0 75 8 , , , cord-286923-o4fj8kx0 75 9 PAR-1 PAR-1 NNP cord-286923-o4fj8kx0 75 10 is be VBZ cord-286923-o4fj8kx0 75 11 undetectable undetectable JJ cord-286923-o4fj8kx0 75 12 after after IN cord-286923-o4fj8kx0 75 13 12 12 CD cord-286923-o4fj8kx0 75 14 weeks week NNS cord-286923-o4fj8kx0 75 15 of of IN cord-286923-o4fj8kx0 75 16 gestation gestation NN cord-286923-o4fj8kx0 75 17 [ [ -LRB- cord-286923-o4fj8kx0 75 18 56 56 CD cord-286923-o4fj8kx0 75 19 ] ] -RRB- cord-286923-o4fj8kx0 75 20 . . . cord-286923-o4fj8kx0 76 1 Taken take VBN cord-286923-o4fj8kx0 76 2 together together RB cord-286923-o4fj8kx0 76 3 , , , cord-286923-o4fj8kx0 76 4 the the DT cord-286923-o4fj8kx0 76 5 suppression suppression NN cord-286923-o4fj8kx0 76 6 of of IN cord-286923-o4fj8kx0 76 7 PAR-1 PAR-1 NNP cord-286923-o4fj8kx0 76 8 expression expression NN cord-286923-o4fj8kx0 76 9 and and CC cord-286923-o4fj8kx0 76 10 the the DT cord-286923-o4fj8kx0 76 11 domination domination NN cord-286923-o4fj8kx0 76 12 of of IN cord-286923-o4fj8kx0 76 13 Th-2 Th-2 NNP cord-286923-o4fj8kx0 76 14 anti anti JJ cord-286923-o4fj8kx0 76 15 - - JJ cord-286923-o4fj8kx0 76 16 inflammatory inflammatory JJ cord-286923-o4fj8kx0 76 17 state state NN cord-286923-o4fj8kx0 76 18 during during IN cord-286923-o4fj8kx0 76 19 pregnancy pregnancy NN cord-286923-o4fj8kx0 76 20 may may MD cord-286923-o4fj8kx0 76 21 contribute contribute VB cord-286923-o4fj8kx0 76 22 to to IN cord-286923-o4fj8kx0 76 23 the the DT cord-286923-o4fj8kx0 76 24 relatively relatively RB cord-286923-o4fj8kx0 76 25 benign benign JJ cord-286923-o4fj8kx0 76 26 course course NN cord-286923-o4fj8kx0 76 27 of of IN cord-286923-o4fj8kx0 76 28 COVID-19 covid-19 DT cord-286923-o4fj8kx0 76 29 in in IN cord-286923-o4fj8kx0 76 30 normal normal JJ cord-286923-o4fj8kx0 76 31 pregnancy pregnancy NN cord-286923-o4fj8kx0 76 32 . . . cord-286923-o4fj8kx0 77 1 Further further RB cord-286923-o4fj8kx0 77 2 , , , cord-286923-o4fj8kx0 77 3 being be VBG cord-286923-o4fj8kx0 77 4 the the DT cord-286923-o4fj8kx0 77 5 risk risk NN cord-286923-o4fj8kx0 77 6 of of IN cord-286923-o4fj8kx0 77 7 DIC DIC NNP cord-286923-o4fj8kx0 77 8 in in IN cord-286923-o4fj8kx0 77 9 women woman NNS cord-286923-o4fj8kx0 77 10 with with IN cord-286923-o4fj8kx0 77 11 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 77 12 is be VBZ cord-286923-o4fj8kx0 77 13 lower low JJR cord-286923-o4fj8kx0 77 14 while while IN cord-286923-o4fj8kx0 77 15 pregnancy pregnancy NN cord-286923-o4fj8kx0 77 16 is be VBZ cord-286923-o4fj8kx0 77 17 a a DT cord-286923-o4fj8kx0 77 18 hypercoagulable hypercoagulable JJ cord-286923-o4fj8kx0 77 19 state state NN cord-286923-o4fj8kx0 77 20 [ [ -LRB- cord-286923-o4fj8kx0 77 21 57 57 CD cord-286923-o4fj8kx0 77 22 ] ] -RRB- cord-286923-o4fj8kx0 77 23 , , , cord-286923-o4fj8kx0 77 24 which which WDT cord-286923-o4fj8kx0 77 25 is be VBZ cord-286923-o4fj8kx0 77 26 another another DT cord-286923-o4fj8kx0 77 27 evidence evidence NN cord-286923-o4fj8kx0 77 28 to to TO cord-286923-o4fj8kx0 77 29 deduce deduce VB cord-286923-o4fj8kx0 77 30 that that IN cord-286923-o4fj8kx0 77 31 the the DT cord-286923-o4fj8kx0 77 32 anti anti JJ cord-286923-o4fj8kx0 77 33 - - JJ cord-286923-o4fj8kx0 77 34 inflammatory inflammatory JJ cord-286923-o4fj8kx0 77 35 cytokines cytokine NNS cord-286923-o4fj8kx0 77 36 and and CC cord-286923-o4fj8kx0 77 37 placental placental JJ cord-286923-o4fj8kx0 77 38 hormones hormone NNS cord-286923-o4fj8kx0 77 39 are be VBP cord-286923-o4fj8kx0 77 40 strong strong JJ cord-286923-o4fj8kx0 77 41 in in IN cord-286923-o4fj8kx0 77 42 normal normal JJ cord-286923-o4fj8kx0 77 43 pregnancy pregnancy NN cord-286923-o4fj8kx0 77 44 . . . cord-286923-o4fj8kx0 78 1 As as IN cord-286923-o4fj8kx0 78 2 noted note VBN cord-286923-o4fj8kx0 78 3 earlier early RBR cord-286923-o4fj8kx0 78 4 , , , cord-286923-o4fj8kx0 78 5 progesterone progesterone NN cord-286923-o4fj8kx0 78 6 is be VBZ cord-286923-o4fj8kx0 78 7 one one CD cord-286923-o4fj8kx0 78 8 of of IN cord-286923-o4fj8kx0 78 9 the the DT cord-286923-o4fj8kx0 78 10 anti anti JJ cord-286923-o4fj8kx0 78 11 - - JJ cord-286923-o4fj8kx0 78 12 inflammatory inflammatory JJ cord-286923-o4fj8kx0 78 13 hormones hormone NNS cord-286923-o4fj8kx0 78 14 . . . cord-286923-o4fj8kx0 79 1 It -PRON- PRP cord-286923-o4fj8kx0 79 2 promotes promote VBZ cord-286923-o4fj8kx0 79 3 the the DT cord-286923-o4fj8kx0 79 4 production production NN cord-286923-o4fj8kx0 79 5 of of IN cord-286923-o4fj8kx0 79 6 Th-2 Th-2 NNP cord-286923-o4fj8kx0 79 7 cytokines cytokine NNS cord-286923-o4fj8kx0 79 8 to to TO cord-286923-o4fj8kx0 79 9 protect protect VB cord-286923-o4fj8kx0 79 10 the the DT cord-286923-o4fj8kx0 79 11 pregnancy pregnancy NN cord-286923-o4fj8kx0 79 12 [ [ -LRB- cord-286923-o4fj8kx0 79 13 58 58 CD cord-286923-o4fj8kx0 79 14 ] ] -RRB- cord-286923-o4fj8kx0 80 1 [ [ -LRB- cord-286923-o4fj8kx0 80 2 59 59 CD cord-286923-o4fj8kx0 80 3 ] ] -RRB- cord-286923-o4fj8kx0 80 4 [ [ -LRB- cord-286923-o4fj8kx0 80 5 60 60 CD cord-286923-o4fj8kx0 80 6 ] ] -RRB- cord-286923-o4fj8kx0 80 7 . . . cord-286923-o4fj8kx0 81 1 The the DT cord-286923-o4fj8kx0 81 2 increased increased JJ cord-286923-o4fj8kx0 81 3 level level NN cord-286923-o4fj8kx0 81 4 of of IN cord-286923-o4fj8kx0 81 5 progesterone progesterone NN cord-286923-o4fj8kx0 81 6 ( ( -LRB- cord-286923-o4fj8kx0 81 7 mainly mainly RB cord-286923-o4fj8kx0 81 8 from from IN cord-286923-o4fj8kx0 81 9 the the DT cord-286923-o4fj8kx0 81 10 placenta placenta NN cord-286923-o4fj8kx0 81 11 ) ) -RRB- cord-286923-o4fj8kx0 81 12 stimulates stimulate VBZ cord-286923-o4fj8kx0 81 13 the the DT cord-286923-o4fj8kx0 81 14 synthesis synthesis NN cord-286923-o4fj8kx0 81 15 of of IN cord-286923-o4fj8kx0 81 16 progesterone progesterone NN cord-286923-o4fj8kx0 81 17 - - HYPH cord-286923-o4fj8kx0 81 18 induced induce VBN cord-286923-o4fj8kx0 81 19 binding binding NN cord-286923-o4fj8kx0 81 20 factor factor NN cord-286923-o4fj8kx0 81 21 ( ( -LRB- cord-286923-o4fj8kx0 81 22 PIBF PIBF NNP cord-286923-o4fj8kx0 81 23 ) ) -RRB- cord-286923-o4fj8kx0 81 24 in in IN cord-286923-o4fj8kx0 81 25 lymphocytes lymphocyte NNS cord-286923-o4fj8kx0 81 26 [ [ -LRB- cord-286923-o4fj8kx0 81 27 7 7 CD cord-286923-o4fj8kx0 81 28 ] ] -RRB- cord-286923-o4fj8kx0 81 29 . . . cord-286923-o4fj8kx0 82 1 The the DT cord-286923-o4fj8kx0 82 2 increased increase VBN cord-286923-o4fj8kx0 82 3 concentration concentration NN cord-286923-o4fj8kx0 82 4 of of IN cord-286923-o4fj8kx0 82 5 PIBF PIBF NNP cord-286923-o4fj8kx0 82 6 in in IN cord-286923-o4fj8kx0 82 7 pregnancy pregnancy NN cord-286923-o4fj8kx0 82 8 promotes promote VBZ cord-286923-o4fj8kx0 82 9 the the DT cord-286923-o4fj8kx0 82 10 differentiation differentiation NN cord-286923-o4fj8kx0 82 11 of of IN cord-286923-o4fj8kx0 82 12 Th-1 Th-1 NNP cord-286923-o4fj8kx0 82 13 cells cell NNS cord-286923-o4fj8kx0 82 14 into into IN cord-286923-o4fj8kx0 82 15 Th-2 Th-2 NNP cord-286923-o4fj8kx0 82 16 cells cell NNS cord-286923-o4fj8kx0 82 17 , , , cord-286923-o4fj8kx0 82 18 which which WDT cord-286923-o4fj8kx0 82 19 results result VBZ cord-286923-o4fj8kx0 82 20 in in IN cord-286923-o4fj8kx0 82 21 augmented augment VBN cord-286923-o4fj8kx0 82 22 production production NN cord-286923-o4fj8kx0 82 23 of of IN cord-286923-o4fj8kx0 82 24 the the DT cord-286923-o4fj8kx0 82 25 aforementioned aforementioned JJ cord-286923-o4fj8kx0 82 26 anti anti JJ cord-286923-o4fj8kx0 82 27 - - JJ cord-286923-o4fj8kx0 82 28 inflammatory inflammatory JJ cord-286923-o4fj8kx0 82 29 cytokines cytokine NNS cord-286923-o4fj8kx0 82 30 and and CC cord-286923-o4fj8kx0 82 31 progressive progressive JJ cord-286923-o4fj8kx0 82 32 decline decline NN cord-286923-o4fj8kx0 82 33 in in IN cord-286923-o4fj8kx0 82 34 Th-1 Th-1 NNP cord-286923-o4fj8kx0 82 35 secreted secrete VBD cord-286923-o4fj8kx0 82 36 proinflammatory proinflammatory JJ cord-286923-o4fj8kx0 82 37 cytokines cytokine NNS cord-286923-o4fj8kx0 82 38 [ [ -LRB- cord-286923-o4fj8kx0 82 39 7 7 CD cord-286923-o4fj8kx0 82 40 ] ] -RRB- cord-286923-o4fj8kx0 82 41 . . . cord-286923-o4fj8kx0 83 1 Abnormally abnormally RB cord-286923-o4fj8kx0 83 2 elevated elevated JJ cord-286923-o4fj8kx0 83 3 IFN IFN NNP cord-286923-o4fj8kx0 83 4 - - HYPH cord-286923-o4fj8kx0 83 5 γ γ NNP cord-286923-o4fj8kx0 83 6 and and CC cord-286923-o4fj8kx0 83 7 TNF TNF NNP cord-286923-o4fj8kx0 83 8 - - HYPH cord-286923-o4fj8kx0 83 9 α α NNP cord-286923-o4fj8kx0 83 10 ( ( -LRB- cord-286923-o4fj8kx0 83 11 Th-1 Th-1 NNP cord-286923-o4fj8kx0 83 12 cytokines cytokine NNS cord-286923-o4fj8kx0 83 13 ) ) -RRB- cord-286923-o4fj8kx0 83 14 can can MD cord-286923-o4fj8kx0 83 15 cause cause VB cord-286923-o4fj8kx0 83 16 damage damage NN cord-286923-o4fj8kx0 83 17 to to IN cord-286923-o4fj8kx0 83 18 the the DT cord-286923-o4fj8kx0 83 19 placenta placenta NN cord-286923-o4fj8kx0 83 20 and and CC cord-286923-o4fj8kx0 83 21 fetal fetal JJ cord-286923-o4fj8kx0 83 22 tissue tissue NN cord-286923-o4fj8kx0 83 23 by by IN cord-286923-o4fj8kx0 83 24 activating activate VBG cord-286923-o4fj8kx0 83 25 the the DT cord-286923-o4fj8kx0 83 26 inflammatory inflammatory JJ cord-286923-o4fj8kx0 83 27 reaction reaction NN cord-286923-o4fj8kx0 83 28 , , , cord-286923-o4fj8kx0 83 29 macrophage macrophage NN cord-286923-o4fj8kx0 83 30 , , , cord-286923-o4fj8kx0 83 31 cytotoxic cytotoxic JJ cord-286923-o4fj8kx0 83 32 cell cell NN cord-286923-o4fj8kx0 83 33 , , , cord-286923-o4fj8kx0 83 34 and and CC cord-286923-o4fj8kx0 83 35 natural natural JJ cord-286923-o4fj8kx0 83 36 killer killer NN cord-286923-o4fj8kx0 83 37 cell cell NN cord-286923-o4fj8kx0 83 38 . . . cord-286923-o4fj8kx0 84 1 Progesterone progesterone NN cord-286923-o4fj8kx0 84 2 also also RB cord-286923-o4fj8kx0 84 3 inhibits inhibit VBZ cord-286923-o4fj8kx0 84 4 macrophage macrophage NN cord-286923-o4fj8kx0 84 5 and and CC cord-286923-o4fj8kx0 84 6 natural natural JJ cord-286923-o4fj8kx0 84 7 killer killer NN cord-286923-o4fj8kx0 84 8 cell cell NN cord-286923-o4fj8kx0 84 9 activity activity NN cord-286923-o4fj8kx0 84 10 , , , cord-286923-o4fj8kx0 84 11 tolllike tolllike NN cord-286923-o4fj8kx0 84 12 receptor receptor NN cord-286923-o4fj8kx0 84 13 ( ( -LRB- cord-286923-o4fj8kx0 84 14 TLR-4 TLR-4 NNP cord-286923-o4fj8kx0 84 15 ) ) -RRB- cord-286923-o4fj8kx0 84 16 induced induce VBN cord-286923-o4fj8kx0 84 17 cytokine cytokine NN cord-286923-o4fj8kx0 84 18 production production NN cord-286923-o4fj8kx0 84 19 and and CC cord-286923-o4fj8kx0 84 20 TNF TNF NNP cord-286923-o4fj8kx0 84 21 - - HYPH cord-286923-o4fj8kx0 84 22 α α NNP cord-286923-o4fj8kx0 84 23 , , , cord-286923-o4fj8kx0 84 24 thereby thereby RB cord-286923-o4fj8kx0 84 25 exposing expose VBG cord-286923-o4fj8kx0 84 26 to to IN cord-286923-o4fj8kx0 84 27 bacterial bacterial JJ cord-286923-o4fj8kx0 84 28 infection infection NN cord-286923-o4fj8kx0 84 29 and and CC cord-286923-o4fj8kx0 84 30 complications complication NNS cord-286923-o4fj8kx0 84 31 [ [ -LRB- cord-286923-o4fj8kx0 84 32 61 61 CD cord-286923-o4fj8kx0 84 33 ] ] -RRB- cord-286923-o4fj8kx0 84 34 , , , cord-286923-o4fj8kx0 84 35 as as IN cord-286923-o4fj8kx0 84 36 the the DT cord-286923-o4fj8kx0 84 37 Th-2 Th-2 NNP cord-286923-o4fj8kx0 84 38 dominated dominate VBD cord-286923-o4fj8kx0 84 39 immunity immunity NN cord-286923-o4fj8kx0 84 40 increases increase VBZ cord-286923-o4fj8kx0 84 41 the the DT cord-286923-o4fj8kx0 84 42 risk risk NN cord-286923-o4fj8kx0 84 43 of of IN cord-286923-o4fj8kx0 84 44 viral viral JJ cord-286923-o4fj8kx0 84 45 infection infection NN cord-286923-o4fj8kx0 84 46 . . . cord-286923-o4fj8kx0 85 1 In in IN cord-286923-o4fj8kx0 85 2 animal animal NN cord-286923-o4fj8kx0 85 3 model model NN cord-286923-o4fj8kx0 85 4 with with IN cord-286923-o4fj8kx0 85 5 autoimmune autoimmune JJ cord-286923-o4fj8kx0 85 6 encephalomyelitis encephalomyelitis NN cord-286923-o4fj8kx0 85 7 , , , cord-286923-o4fj8kx0 85 8 progesterone progesterone NN cord-286923-o4fj8kx0 85 9 treatment treatment NN cord-286923-o4fj8kx0 85 10 has have VBZ cord-286923-o4fj8kx0 85 11 shown show VBN cord-286923-o4fj8kx0 85 12 a a DT cord-286923-o4fj8kx0 85 13 significant significant JJ cord-286923-o4fj8kx0 85 14 reduction reduction NN cord-286923-o4fj8kx0 85 15 in in IN cord-286923-o4fj8kx0 85 16 disease disease NN cord-286923-o4fj8kx0 85 17 severity severity NN cord-286923-o4fj8kx0 85 18 and and CC cord-286923-o4fj8kx0 85 19 increases increase VBZ cord-286923-o4fj8kx0 85 20 the the DT cord-286923-o4fj8kx0 85 21 level level NN cord-286923-o4fj8kx0 85 22 of of IN cord-286923-o4fj8kx0 85 23 IL-10 IL-10 NNP cord-286923-o4fj8kx0 85 24 [ [ -LRB- cord-286923-o4fj8kx0 85 25 62 62 CD cord-286923-o4fj8kx0 85 26 ] ] -RRB- cord-286923-o4fj8kx0 85 27 , , , cord-286923-o4fj8kx0 85 28 which which WDT cord-286923-o4fj8kx0 85 29 is be VBZ cord-286923-o4fj8kx0 85 30 another another DT cord-286923-o4fj8kx0 85 31 important important JJ cord-286923-o4fj8kx0 85 32 indicator indicator NN cord-286923-o4fj8kx0 85 33 of of IN cord-286923-o4fj8kx0 85 34 its -PRON- PRP$ cord-286923-o4fj8kx0 85 35 multiplied multiply VBN cord-286923-o4fj8kx0 85 36 effect effect NN cord-286923-o4fj8kx0 85 37 . . . cord-286923-o4fj8kx0 86 1 Therefore therefore RB cord-286923-o4fj8kx0 86 2 , , , cord-286923-o4fj8kx0 86 3 the the DT cord-286923-o4fj8kx0 86 4 increased increased JJ cord-286923-o4fj8kx0 86 5 level level NN cord-286923-o4fj8kx0 86 6 of of IN cord-286923-o4fj8kx0 86 7 progesterone progesterone NN cord-286923-o4fj8kx0 86 8 during during IN cord-286923-o4fj8kx0 86 9 pregnancy pregnancy NN cord-286923-o4fj8kx0 86 10 may may MD cord-286923-o4fj8kx0 86 11 complement complement VB cord-286923-o4fj8kx0 86 12 to to IN cord-286923-o4fj8kx0 86 13 the the DT cord-286923-o4fj8kx0 86 14 physiological physiological JJ cord-286923-o4fj8kx0 86 15 defense defense NN cord-286923-o4fj8kx0 86 16 to to IN cord-286923-o4fj8kx0 86 17 COVID-19 covid-19 VB cord-286923-o4fj8kx0 86 18 . . . cord-286923-o4fj8kx0 87 1 The the DT cord-286923-o4fj8kx0 87 2 immune immune JJ cord-286923-o4fj8kx0 87 3 modulating modulating NN cord-286923-o4fj8kx0 87 4 and and CC cord-286923-o4fj8kx0 87 5 anti anti JJ cord-286923-o4fj8kx0 87 6 - - JJ cord-286923-o4fj8kx0 87 7 inflammatory inflammatory JJ cord-286923-o4fj8kx0 87 8 actions action NNS cord-286923-o4fj8kx0 87 9 of of IN cord-286923-o4fj8kx0 87 10 estradiol estradiol NN cord-286923-o4fj8kx0 87 11 ( ( -LRB- cord-286923-o4fj8kx0 87 12 E2 E2 NNP cord-286923-o4fj8kx0 87 13 ) ) -RRB- cord-286923-o4fj8kx0 87 14 and and CC cord-286923-o4fj8kx0 87 15 estriol estriol NNP cord-286923-o4fj8kx0 87 16 ( ( -LRB- cord-286923-o4fj8kx0 87 17 E3 E3 NNP cord-286923-o4fj8kx0 87 18 ) ) -RRB- cord-286923-o4fj8kx0 87 19 is be VBZ cord-286923-o4fj8kx0 87 20 also also RB cord-286923-o4fj8kx0 87 21 well well RB cord-286923-o4fj8kx0 87 22 noted note VBN cord-286923-o4fj8kx0 87 23 during during IN cord-286923-o4fj8kx0 87 24 pregnancy pregnancy NN cord-286923-o4fj8kx0 87 25 . . . cord-286923-o4fj8kx0 88 1 E3 E3 NNP cord-286923-o4fj8kx0 88 2 ( ( -LRB- cord-286923-o4fj8kx0 88 3 90 90 CD cord-286923-o4fj8kx0 88 4 % % NN cord-286923-o4fj8kx0 88 5 of of IN cord-286923-o4fj8kx0 88 6 all all DT cord-286923-o4fj8kx0 88 7 estrogens estrogen NNS cord-286923-o4fj8kx0 88 8 secreted secrete VBN cord-286923-o4fj8kx0 88 9 during during IN cord-286923-o4fj8kx0 88 10 pregnancy pregnancy NN cord-286923-o4fj8kx0 88 11 ) ) -RRB- cord-286923-o4fj8kx0 88 12 increases increase VBZ cord-286923-o4fj8kx0 88 13 1000 1000 CD cord-286923-o4fj8kx0 88 14 times time NNS cord-286923-o4fj8kx0 88 15 during during IN cord-286923-o4fj8kx0 88 16 pregnancy pregnancy NN cord-286923-o4fj8kx0 88 17 from from IN cord-286923-o4fj8kx0 88 18 the the DT cord-286923-o4fj8kx0 88 19 only only JJ cord-286923-o4fj8kx0 88 20 detectable detectable JJ cord-286923-o4fj8kx0 88 21 level level NN cord-286923-o4fj8kx0 88 22 in in IN cord-286923-o4fj8kx0 88 23 non non JJ cord-286923-o4fj8kx0 88 24 - - JJ cord-286923-o4fj8kx0 88 25 pregnant pregnant JJ cord-286923-o4fj8kx0 88 26 women woman NNS cord-286923-o4fj8kx0 88 27 [ [ -LRB- cord-286923-o4fj8kx0 88 28 63 63 CD cord-286923-o4fj8kx0 88 29 ] ] -RRB- cord-286923-o4fj8kx0 88 30 . . . cord-286923-o4fj8kx0 89 1 Emphatic emphatic JJ cord-286923-o4fj8kx0 89 2 E3 E3 NNP cord-286923-o4fj8kx0 89 3 increases increase VBZ cord-286923-o4fj8kx0 89 4 the the DT cord-286923-o4fj8kx0 89 5 production production NN cord-286923-o4fj8kx0 89 6 of of IN cord-286923-o4fj8kx0 89 7 anti anti JJ cord-286923-o4fj8kx0 89 8 - - JJ cord-286923-o4fj8kx0 89 9 inflammatory inflammatory JJ cord-286923-o4fj8kx0 89 10 cytokines cytokine NNS cord-286923-o4fj8kx0 89 11 ( ( -LRB- cord-286923-o4fj8kx0 89 12 IL-10 IL-10 NNP cord-286923-o4fj8kx0 89 13 and and CC cord-286923-o4fj8kx0 89 14 IL-5 IL-5 NNP cord-286923-o4fj8kx0 89 15 ) ) -RRB- cord-286923-o4fj8kx0 89 16 and and CC cord-286923-o4fj8kx0 89 17 reduces reduce VBZ cord-286923-o4fj8kx0 89 18 the the DT cord-286923-o4fj8kx0 89 19 production production NN cord-286923-o4fj8kx0 89 20 of of IN cord-286923-o4fj8kx0 89 21 proinflammatory proinflammatory JJ cord-286923-o4fj8kx0 89 22 cytokines cytokine NNS cord-286923-o4fj8kx0 89 23 ( ( -LRB- cord-286923-o4fj8kx0 89 24 like like IN cord-286923-o4fj8kx0 89 25 TNF TNF NNP cord-286923-o4fj8kx0 89 26 - - HYPH cord-286923-o4fj8kx0 89 27 α α NNP cord-286923-o4fj8kx0 89 28 ) ) -RRB- cord-286923-o4fj8kx0 89 29 [ [ -LRB- cord-286923-o4fj8kx0 89 30 64 64 CD cord-286923-o4fj8kx0 89 31 ] ] -RRB- cord-286923-o4fj8kx0 89 32 . . . cord-286923-o4fj8kx0 90 1 The the DT cord-286923-o4fj8kx0 90 2 relatively relatively RB cord-286923-o4fj8kx0 90 3 increased increase VBN cord-286923-o4fj8kx0 90 4 E2 e2 NN cord-286923-o4fj8kx0 90 5 level level NN cord-286923-o4fj8kx0 90 6 ( ( -LRB- cord-286923-o4fj8kx0 90 7 100 100 CD cord-286923-o4fj8kx0 90 8 times time NNS cord-286923-o4fj8kx0 90 9 ) ) -RRB- cord-286923-o4fj8kx0 90 10 [ [ -LRB- cord-286923-o4fj8kx0 90 11 63 63 CD cord-286923-o4fj8kx0 90 12 ] ] -RRB- cord-286923-o4fj8kx0 90 13 and and CC cord-286923-o4fj8kx0 90 14 the the DT cord-286923-o4fj8kx0 90 15 extremely extremely RB cord-286923-o4fj8kx0 90 16 elevated elevated JJ cord-286923-o4fj8kx0 90 17 E3 e3 NN cord-286923-o4fj8kx0 90 18 level level NN cord-286923-o4fj8kx0 90 19 during during IN cord-286923-o4fj8kx0 90 20 pregnancy pregnancy NN cord-286923-o4fj8kx0 90 21 promote promote VBP cord-286923-o4fj8kx0 90 22 Th-2 Th-2 NNP cord-286923-o4fj8kx0 90 23 responses response NNS cord-286923-o4fj8kx0 90 24 and and CC cord-286923-o4fj8kx0 90 25 humoral humoral JJ cord-286923-o4fj8kx0 90 26 immunity immunity NN cord-286923-o4fj8kx0 90 27 . . . cord-286923-o4fj8kx0 91 1 Whereas whereas IN cord-286923-o4fj8kx0 91 2 a a DT cord-286923-o4fj8kx0 91 3 reduction reduction NN cord-286923-o4fj8kx0 91 4 in in IN cord-286923-o4fj8kx0 91 5 E2 E2 NNP cord-286923-o4fj8kx0 91 6 level level NN cord-286923-o4fj8kx0 91 7 results result NNS cord-286923-o4fj8kx0 91 8 in in IN cord-286923-o4fj8kx0 91 9 augmented augment VBN cord-286923-o4fj8kx0 91 10 Th-1 Th-1 NNP cord-286923-o4fj8kx0 91 11 responses response NNS cord-286923-o4fj8kx0 91 12 / / SYM cord-286923-o4fj8kx0 91 13 proinflammatory proinflammatory JJ cord-286923-o4fj8kx0 91 14 cell cell NN cord-286923-o4fj8kx0 91 15 - - HYPH cord-286923-o4fj8kx0 91 16 mediated mediate VBN cord-286923-o4fj8kx0 91 17 immunity immunity NN cord-286923-o4fj8kx0 91 18 and and CC cord-286923-o4fj8kx0 91 19 bad bad JJ cord-286923-o4fj8kx0 91 20 pregnancy pregnancy NN cord-286923-o4fj8kx0 91 21 outcome outcome NN cord-286923-o4fj8kx0 91 22 [ [ -LRB- cord-286923-o4fj8kx0 91 23 65 65 CD cord-286923-o4fj8kx0 91 24 , , , cord-286923-o4fj8kx0 91 25 66 66 CD cord-286923-o4fj8kx0 91 26 ] ] -RRB- cord-286923-o4fj8kx0 91 27 . . . cord-286923-o4fj8kx0 92 1 As as IN cord-286923-o4fj8kx0 92 2 a a DT cord-286923-o4fj8kx0 92 3 result result NN cord-286923-o4fj8kx0 92 4 , , , cord-286923-o4fj8kx0 92 5 the the DT cord-286923-o4fj8kx0 92 6 anti anti JJ cord-286923-o4fj8kx0 92 7 - - JJ cord-286923-o4fj8kx0 92 8 inflammatory inflammatory JJ cord-286923-o4fj8kx0 92 9 action action NN cord-286923-o4fj8kx0 92 10 of of IN cord-286923-o4fj8kx0 92 11 estriol estriol NNP cord-286923-o4fj8kx0 92 12 , , , cord-286923-o4fj8kx0 92 13 in in IN cord-286923-o4fj8kx0 92 14 particular particular JJ cord-286923-o4fj8kx0 92 15 , , , cord-286923-o4fj8kx0 92 16 is be VBZ cord-286923-o4fj8kx0 92 17 opening open VBG cord-286923-o4fj8kx0 92 18 a a DT cord-286923-o4fj8kx0 92 19 new new JJ cord-286923-o4fj8kx0 92 20 horizon horizon NN cord-286923-o4fj8kx0 92 21 of of IN cord-286923-o4fj8kx0 92 22 research research NN cord-286923-o4fj8kx0 92 23 to to TO cord-286923-o4fj8kx0 92 24 use use VB cord-286923-o4fj8kx0 92 25 it -PRON- PRP cord-286923-o4fj8kx0 92 26 as as IN cord-286923-o4fj8kx0 92 27 an an DT cord-286923-o4fj8kx0 92 28 important important JJ cord-286923-o4fj8kx0 92 29 therapeutic therapeutic JJ cord-286923-o4fj8kx0 92 30 option option NN cord-286923-o4fj8kx0 92 31 for for IN cord-286923-o4fj8kx0 92 32 viral viral JJ cord-286923-o4fj8kx0 92 33 , , , cord-286923-o4fj8kx0 92 34 autoimmune autoimmune JJ cord-286923-o4fj8kx0 92 35 and and CC cord-286923-o4fj8kx0 92 36 neurodegenerative neurodegenerative JJ cord-286923-o4fj8kx0 92 37 diseases disease NNS cord-286923-o4fj8kx0 92 38 outside outside IN cord-286923-o4fj8kx0 92 39 pregnancy pregnancy NN cord-286923-o4fj8kx0 92 40 , , , cord-286923-o4fj8kx0 92 41 including include VBG cord-286923-o4fj8kx0 92 42 men man NNS cord-286923-o4fj8kx0 92 43 and and CC cord-286923-o4fj8kx0 92 44 postmenopausal postmenopausal JJ cord-286923-o4fj8kx0 92 45 women woman NNS cord-286923-o4fj8kx0 92 46 [ [ -LRB- cord-286923-o4fj8kx0 92 47 67 67 CD cord-286923-o4fj8kx0 92 48 ] ] -RRB- cord-286923-o4fj8kx0 92 49 [ [ -LRB- cord-286923-o4fj8kx0 92 50 68 68 CD cord-286923-o4fj8kx0 92 51 ] ] -RRB- cord-286923-o4fj8kx0 92 52 [ [ -LRB- cord-286923-o4fj8kx0 92 53 69 69 CD cord-286923-o4fj8kx0 92 54 ] ] -RRB- cord-286923-o4fj8kx0 92 55 . . . cord-286923-o4fj8kx0 93 1 In in IN cord-286923-o4fj8kx0 93 2 animal animal NN cord-286923-o4fj8kx0 93 3 models model NNS cord-286923-o4fj8kx0 93 4 , , , cord-286923-o4fj8kx0 93 5 E3 E3 NNP cord-286923-o4fj8kx0 93 6 had have VBD cord-286923-o4fj8kx0 93 7 significantly significantly RB cord-286923-o4fj8kx0 93 8 reduced reduce VBN cord-286923-o4fj8kx0 93 9 proinflammatory proinflammatory JJ cord-286923-o4fj8kx0 93 10 transcriptional transcriptional JJ cord-286923-o4fj8kx0 93 11 activity activity NN cord-286923-o4fj8kx0 93 12 , , , cord-286923-o4fj8kx0 93 13 pulmonary pulmonary JJ cord-286923-o4fj8kx0 93 14 immune immune JJ cord-286923-o4fj8kx0 93 15 cell cell NN cord-286923-o4fj8kx0 93 16 recruitment recruitment NN cord-286923-o4fj8kx0 93 17 , , , cord-286923-o4fj8kx0 93 18 and and CC cord-286923-o4fj8kx0 93 19 pulmonary pulmonary JJ cord-286923-o4fj8kx0 93 20 inflammation inflammation NN cord-286923-o4fj8kx0 93 21 during during IN cord-286923-o4fj8kx0 93 22 influenza influenza NN cord-286923-o4fj8kx0 93 23 A a DT cord-286923-o4fj8kx0 93 24 virus virus NN cord-286923-o4fj8kx0 93 25 infection infection NN cord-286923-o4fj8kx0 93 26 [ [ -LRB- cord-286923-o4fj8kx0 93 27 70 70 CD cord-286923-o4fj8kx0 93 28 ] ] -RRB- cord-286923-o4fj8kx0 93 29 . . . cord-286923-o4fj8kx0 94 1 A a DT cord-286923-o4fj8kx0 94 2 pilot pilot NN cord-286923-o4fj8kx0 94 3 trial trial NN cord-286923-o4fj8kx0 94 4 of of IN cord-286923-o4fj8kx0 94 5 exogenous exogenous JJ cord-286923-o4fj8kx0 94 6 estriol estriol NNP cord-286923-o4fj8kx0 94 7 administration administration NNP cord-286923-o4fj8kx0 94 8 to to IN cord-286923-o4fj8kx0 94 9 non non JJ cord-286923-o4fj8kx0 94 10 - - JJ cord-286923-o4fj8kx0 94 11 pregnant pregnant JJ cord-286923-o4fj8kx0 94 12 women woman NNS cord-286923-o4fj8kx0 94 13 with with IN cord-286923-o4fj8kx0 94 14 multiple multiple JJ cord-286923-o4fj8kx0 94 15 sclerosis sclerosis NN cord-286923-o4fj8kx0 94 16 has have VBZ cord-286923-o4fj8kx0 94 17 resulted result VBN cord-286923-o4fj8kx0 94 18 in in IN cord-286923-o4fj8kx0 94 19 80 80 CD cord-286923-o4fj8kx0 94 20 % % NN cord-286923-o4fj8kx0 94 21 reduction reduction NN cord-286923-o4fj8kx0 94 22 in in IN cord-286923-o4fj8kx0 94 23 gadolinium gadolinium NN cord-286923-o4fj8kx0 94 24 - - HYPH cord-286923-o4fj8kx0 94 25 enhancing enhance VBG cord-286923-o4fj8kx0 94 26 lesions lesion NNS cord-286923-o4fj8kx0 94 27 from from IN cord-286923-o4fj8kx0 94 28 the the DT cord-286923-o4fj8kx0 94 29 pretreatment pretreatment NN cord-286923-o4fj8kx0 94 30 state state NN cord-286923-o4fj8kx0 94 31 within within IN cord-286923-o4fj8kx0 94 32 3 3 CD cord-286923-o4fj8kx0 94 33 months month NNS cord-286923-o4fj8kx0 94 34 , , , cord-286923-o4fj8kx0 94 35 which which WDT cord-286923-o4fj8kx0 94 36 was be VBD cord-286923-o4fj8kx0 94 37 correlated correlate VBN cord-286923-o4fj8kx0 94 38 with with IN cord-286923-o4fj8kx0 94 39 the the DT cord-286923-o4fj8kx0 94 40 favorable favorable JJ cord-286923-o4fj8kx0 94 41 shift shift NN cord-286923-o4fj8kx0 94 42 in in IN cord-286923-o4fj8kx0 94 43 cytokine cytokine NN cord-286923-o4fj8kx0 94 44 profiles profile NNS cord-286923-o4fj8kx0 94 45 [ [ -LRB- cord-286923-o4fj8kx0 94 46 64 64 CD cord-286923-o4fj8kx0 94 47 , , , cord-286923-o4fj8kx0 94 48 71 71 CD cord-286923-o4fj8kx0 94 49 ] ] -RRB- cord-286923-o4fj8kx0 94 50 . . . cord-286923-o4fj8kx0 95 1 Therefore therefore RB cord-286923-o4fj8kx0 95 2 , , , cord-286923-o4fj8kx0 95 3 the the DT cord-286923-o4fj8kx0 95 4 Th-2 Th-2 NNP cord-286923-o4fj8kx0 95 5 immunity immunity NN cord-286923-o4fj8kx0 95 6 activation activation NN cord-286923-o4fj8kx0 95 7 and and CC cord-286923-o4fj8kx0 95 8 anti anti JJ cord-286923-o4fj8kx0 95 9 - - JJ cord-286923-o4fj8kx0 95 10 inflammatory inflammatory JJ cord-286923-o4fj8kx0 95 11 actions action NNS cord-286923-o4fj8kx0 95 12 of of IN cord-286923-o4fj8kx0 95 13 E2 E2 NNP cord-286923-o4fj8kx0 95 14 and and CC cord-286923-o4fj8kx0 95 15 E3 E3 NNP cord-286923-o4fj8kx0 95 16 are be VBP cord-286923-o4fj8kx0 95 17 likely likely JJ cord-286923-o4fj8kx0 95 18 to to TO cord-286923-o4fj8kx0 95 19 contribute contribute VB cord-286923-o4fj8kx0 95 20 to to TO cord-286923-o4fj8kx0 95 21 reduce reduce VB cord-286923-o4fj8kx0 95 22 the the DT cord-286923-o4fj8kx0 95 23 proinflammatory proinflammatory JJ cord-286923-o4fj8kx0 95 24 cytokine cytokine NN cord-286923-o4fj8kx0 95 25 storm storm NN cord-286923-o4fj8kx0 95 26 and and CC cord-286923-o4fj8kx0 95 27 subsequent subsequent JJ cord-286923-o4fj8kx0 95 28 complications complication NNS cord-286923-o4fj8kx0 95 29 of of IN cord-286923-o4fj8kx0 95 30 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 95 31 , , , cord-286923-o4fj8kx0 95 32 which which WDT cord-286923-o4fj8kx0 95 33 need need VBP cord-286923-o4fj8kx0 95 34 to to TO cord-286923-o4fj8kx0 95 35 be be VB cord-286923-o4fj8kx0 95 36 further further RB cord-286923-o4fj8kx0 95 37 explored explore VBN cord-286923-o4fj8kx0 95 38 with with IN cord-286923-o4fj8kx0 95 39 clinical clinical JJ cord-286923-o4fj8kx0 95 40 trial trial NN cord-286923-o4fj8kx0 95 41 . . . cord-286923-o4fj8kx0 96 1 Vitamin vitamin NN cord-286923-o4fj8kx0 96 2 D d NN cord-286923-o4fj8kx0 96 3 is be VBZ cord-286923-o4fj8kx0 96 4 another another DT cord-286923-o4fj8kx0 96 5 important important JJ cord-286923-o4fj8kx0 96 6 hormone hormone NN cord-286923-o4fj8kx0 96 7 , , , cord-286923-o4fj8kx0 96 8 which which WDT cord-286923-o4fj8kx0 96 9 has have VBZ cord-286923-o4fj8kx0 96 10 both both DT cord-286923-o4fj8kx0 96 11 immune immune JJ cord-286923-o4fj8kx0 96 12 modulation modulation NN cord-286923-o4fj8kx0 96 13 and and CC cord-286923-o4fj8kx0 96 14 antiinflammatory antiinflammatory JJ cord-286923-o4fj8kx0 96 15 actions action NNS cord-286923-o4fj8kx0 96 16 [ [ -LRB- cord-286923-o4fj8kx0 96 17 72 72 CD cord-286923-o4fj8kx0 96 18 ] ] -RRB- cord-286923-o4fj8kx0 96 19 , , , cord-286923-o4fj8kx0 96 20 that that WDT cord-286923-o4fj8kx0 96 21 can can MD cord-286923-o4fj8kx0 96 22 positively positively RB cord-286923-o4fj8kx0 96 23 influence influence VB cord-286923-o4fj8kx0 96 24 pregnancy pregnancy NN cord-286923-o4fj8kx0 96 25 outcome outcome NN cord-286923-o4fj8kx0 96 26 and and CC cord-286923-o4fj8kx0 96 27 response response NN cord-286923-o4fj8kx0 96 28 to to IN cord-286923-o4fj8kx0 96 29 acute acute JJ cord-286923-o4fj8kx0 96 30 and and CC cord-286923-o4fj8kx0 96 31 chronic chronic JJ cord-286923-o4fj8kx0 96 32 inflammatory inflammatory JJ cord-286923-o4fj8kx0 96 33 diseases disease NNS cord-286923-o4fj8kx0 96 34 during during IN cord-286923-o4fj8kx0 96 35 pregnancy pregnancy NN cord-286923-o4fj8kx0 96 36 . . . cord-286923-o4fj8kx0 97 1 Apart apart RB cord-286923-o4fj8kx0 97 2 from from IN cord-286923-o4fj8kx0 97 3 a a DT cord-286923-o4fj8kx0 97 4 wide wide JJ cord-286923-o4fj8kx0 97 5 array array NN cord-286923-o4fj8kx0 97 6 of of IN cord-286923-o4fj8kx0 97 7 J J NNP cord-286923-o4fj8kx0 97 8 o o NNP cord-286923-o4fj8kx0 97 9 u u NN cord-286923-o4fj8kx0 97 10 r r NNP cord-286923-o4fj8kx0 97 11 n n NN cord-286923-o4fj8kx0 97 12 a a DT cord-286923-o4fj8kx0 97 13 l l NN cord-286923-o4fj8kx0 97 14 P p NN cord-286923-o4fj8kx0 97 15 r r NN cord-286923-o4fj8kx0 97 16 e e NN cord-286923-o4fj8kx0 97 17 -p -p NN cord-286923-o4fj8kx0 97 18 r r NN cord-286923-o4fj8kx0 97 19 o o NN cord-286923-o4fj8kx0 97 20 o o NN cord-286923-o4fj8kx0 97 21 f f NN cord-286923-o4fj8kx0 97 22 immune immune JJ cord-286923-o4fj8kx0 97 23 cell cell NN cord-286923-o4fj8kx0 97 24 activation activation NN cord-286923-o4fj8kx0 97 25 during during IN cord-286923-o4fj8kx0 97 26 pregnancy pregnancy NN cord-286923-o4fj8kx0 97 27 , , , cord-286923-o4fj8kx0 97 28 the the DT cord-286923-o4fj8kx0 97 29 stimulating stimulating JJ cord-286923-o4fj8kx0 97 30 effect effect NN cord-286923-o4fj8kx0 97 31 to to IN cord-286923-o4fj8kx0 97 32 Th-2 Th-2 NNP cord-286923-o4fj8kx0 97 33 cytokine cytokine NN cord-286923-o4fj8kx0 97 34 production production NN cord-286923-o4fj8kx0 97 35 and and CC cord-286923-o4fj8kx0 97 36 the the DT cord-286923-o4fj8kx0 97 37 inhibition inhibition NN cord-286923-o4fj8kx0 97 38 effect effect NN cord-286923-o4fj8kx0 97 39 to to IN cord-286923-o4fj8kx0 97 40 Th-1 Th-1 NNP cord-286923-o4fj8kx0 97 41 / / SYM cord-286923-o4fj8kx0 97 42 Th-17 Th-17 NNP cord-286923-o4fj8kx0 97 43 cytokine cytokine NN cord-286923-o4fj8kx0 97 44 release release NN cord-286923-o4fj8kx0 97 45 is be VBZ cord-286923-o4fj8kx0 97 46 a a DT cord-286923-o4fj8kx0 97 47 synchronized synchronized JJ cord-286923-o4fj8kx0 97 48 effect effect NN cord-286923-o4fj8kx0 97 49 of of IN cord-286923-o4fj8kx0 97 50 vitamin vitamin NN cord-286923-o4fj8kx0 97 51 D d NN cord-286923-o4fj8kx0 97 52 with with IN cord-286923-o4fj8kx0 97 53 progesterone progesterone NN cord-286923-o4fj8kx0 97 54 and and CC cord-286923-o4fj8kx0 97 55 estriol estriol NNP cord-286923-o4fj8kx0 97 56 [ [ -LRB- cord-286923-o4fj8kx0 97 57 73 73 CD cord-286923-o4fj8kx0 97 58 , , , cord-286923-o4fj8kx0 97 59 74 74 CD cord-286923-o4fj8kx0 97 60 ] ] -RRB- cord-286923-o4fj8kx0 97 61 . . . cord-286923-o4fj8kx0 98 1 A a DT cord-286923-o4fj8kx0 98 2 few few JJ cord-286923-o4fj8kx0 98 3 anecdotal anecdotal JJ cord-286923-o4fj8kx0 98 4 evidences evidence NNS cord-286923-o4fj8kx0 98 5 have have VBP cord-286923-o4fj8kx0 98 6 shown show VBN cord-286923-o4fj8kx0 98 7 the the DT cord-286923-o4fj8kx0 98 8 increased increase VBN cord-286923-o4fj8kx0 98 9 risk risk NN cord-286923-o4fj8kx0 98 10 of of IN cord-286923-o4fj8kx0 98 11 severity severity NN cord-286923-o4fj8kx0 98 12 and and CC cord-286923-o4fj8kx0 98 13 mortality mortality NN cord-286923-o4fj8kx0 98 14 among among IN cord-286923-o4fj8kx0 98 15 non non JJ cord-286923-o4fj8kx0 98 16 - - JJ cord-286923-o4fj8kx0 98 17 pregnant pregnant JJ cord-286923-o4fj8kx0 98 18 COVID-19 covid-19 JJ cord-286923-o4fj8kx0 98 19 patients patient NNS cord-286923-o4fj8kx0 98 20 when when WRB cord-286923-o4fj8kx0 98 21 there there EX cord-286923-o4fj8kx0 98 22 is be VBZ cord-286923-o4fj8kx0 98 23 vitamin vitamin NN cord-286923-o4fj8kx0 98 24 D D NNP cord-286923-o4fj8kx0 98 25 deficiency deficiency NN cord-286923-o4fj8kx0 98 26 in in IN cord-286923-o4fj8kx0 98 27 their -PRON- PRP$ cord-286923-o4fj8kx0 98 28 serum serum NN cord-286923-o4fj8kx0 98 29 ( ( -LRB- cord-286923-o4fj8kx0 98 30 1 1 CD cord-286923-o4fj8kx0 99 1 , , , cord-286923-o4fj8kx0 99 2 25-Dihydroxy 25-dihydroxy CD cord-286923-o4fj8kx0 99 3 vitamin vitamin NN cord-286923-o4fj8kx0 99 4 D3 D3 NNP cord-286923-o4fj8kx0 99 5 < < XX cord-286923-o4fj8kx0 100 1 10 10 CD cord-286923-o4fj8kx0 100 2 mg mg NNP cord-286923-o4fj8kx0 100 3 / / SYM cord-286923-o4fj8kx0 100 4 dl dl NN cord-286923-o4fj8kx0 100 5 ) ) -RRB- cord-286923-o4fj8kx0 101 1 [ [ -LRB- cord-286923-o4fj8kx0 101 2 75 75 CD cord-286923-o4fj8kx0 101 3 ] ] -RRB- cord-286923-o4fj8kx0 101 4 [ [ -LRB- cord-286923-o4fj8kx0 101 5 76 76 CD cord-286923-o4fj8kx0 101 6 ] ] -RRB- cord-286923-o4fj8kx0 101 7 [ [ -LRB- cord-286923-o4fj8kx0 101 8 77 77 CD cord-286923-o4fj8kx0 101 9 ] ] -RRB- cord-286923-o4fj8kx0 101 10 . . . cord-286923-o4fj8kx0 102 1 As as IN cord-286923-o4fj8kx0 102 2 learnt learn VBN cord-286923-o4fj8kx0 102 3 from from IN cord-286923-o4fj8kx0 102 4 animal animal NN cord-286923-o4fj8kx0 102 5 models model NNS cord-286923-o4fj8kx0 102 6 and and CC cord-286923-o4fj8kx0 102 7 human human JJ cord-286923-o4fj8kx0 102 8 trials trial NNS cord-286923-o4fj8kx0 102 9 , , , cord-286923-o4fj8kx0 102 10 among among IN cord-286923-o4fj8kx0 102 11 many many JJ cord-286923-o4fj8kx0 102 12 of of IN cord-286923-o4fj8kx0 102 13 the the DT cord-286923-o4fj8kx0 102 14 Vitamin vitamin NN cord-286923-o4fj8kx0 102 15 D d NN cord-286923-o4fj8kx0 102 16 innate innate JJ cord-286923-o4fj8kx0 102 17 and and CC cord-286923-o4fj8kx0 102 18 adaptive adaptive JJ cord-286923-o4fj8kx0 102 19 immune immune JJ cord-286923-o4fj8kx0 102 20 modulating modulate VBG cord-286923-o4fj8kx0 102 21 actions action NNS cord-286923-o4fj8kx0 102 22 , , , cord-286923-o4fj8kx0 102 23 its -PRON- PRP$ cord-286923-o4fj8kx0 102 24 inhibitory inhibitory JJ cord-286923-o4fj8kx0 102 25 action action NN cord-286923-o4fj8kx0 102 26 to to IN cord-286923-o4fj8kx0 102 27 IL-6 IL-6 NNP cord-286923-o4fj8kx0 102 28 and and CC cord-286923-o4fj8kx0 102 29 TNF TNF NNP cord-286923-o4fj8kx0 102 30 - - HYPH cord-286923-o4fj8kx0 102 31 α α NNP cord-286923-o4fj8kx0 102 32 [ [ -LRB- cord-286923-o4fj8kx0 102 33 71 71 CD cord-286923-o4fj8kx0 102 34 , , , cord-286923-o4fj8kx0 102 35 78 78 CD cord-286923-o4fj8kx0 102 36 ] ] -RRB- cord-286923-o4fj8kx0 102 37 is be VBZ cord-286923-o4fj8kx0 102 38 implicated implicate VBN cord-286923-o4fj8kx0 102 39 in in IN cord-286923-o4fj8kx0 102 40 the the DT cord-286923-o4fj8kx0 102 41 reduced reduced JJ cord-286923-o4fj8kx0 102 42 risk risk NN cord-286923-o4fj8kx0 102 43 of of IN cord-286923-o4fj8kx0 102 44 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 102 45 in in IN cord-286923-o4fj8kx0 102 46 Vitamin vitamin NN cord-286923-o4fj8kx0 102 47 D d NN cord-286923-o4fj8kx0 102 48 sufficient sufficient JJ cord-286923-o4fj8kx0 102 49 individuals individual NNS cord-286923-o4fj8kx0 102 50 . . . cord-286923-o4fj8kx0 103 1 Vitamin vitamin NN cord-286923-o4fj8kx0 103 2 D d NN cord-286923-o4fj8kx0 103 3 reduces reduce VBZ cord-286923-o4fj8kx0 103 4 the the DT cord-286923-o4fj8kx0 103 5 inflammatory inflammatory NN cord-286923-o4fj8kx0 103 6 and and CC cord-286923-o4fj8kx0 103 7 T t NN cord-286923-o4fj8kx0 103 8 cell cell NN cord-286923-o4fj8kx0 103 9 stimulatory stimulatory JJ cord-286923-o4fj8kx0 103 10 actions action NNS cord-286923-o4fj8kx0 103 11 of of IN cord-286923-o4fj8kx0 103 12 macrophages macrophage NNS cord-286923-o4fj8kx0 103 13 through through IN cord-286923-o4fj8kx0 103 14 an an DT cord-286923-o4fj8kx0 103 15 IL-10dependent IL-10dependent NNP cord-286923-o4fj8kx0 103 16 mechanism mechanism NN cord-286923-o4fj8kx0 103 17 [ [ -LRB- cord-286923-o4fj8kx0 103 18 79 79 CD cord-286923-o4fj8kx0 103 19 ] ] -RRB- cord-286923-o4fj8kx0 103 20 . . . cord-286923-o4fj8kx0 104 1 Other other JJ cord-286923-o4fj8kx0 104 2 investigators investigator NNS cord-286923-o4fj8kx0 104 3 also also RB cord-286923-o4fj8kx0 104 4 verified verify VBD cord-286923-o4fj8kx0 104 5 its -PRON- PRP$ cord-286923-o4fj8kx0 104 6 effect effect NN cord-286923-o4fj8kx0 104 7 in in IN cord-286923-o4fj8kx0 104 8 monocytes monocyte NNS cord-286923-o4fj8kx0 104 9 IL-10 IL-10 NNP cord-286923-o4fj8kx0 104 10 production production NN cord-286923-o4fj8kx0 104 11 ( ( -LRB- cord-286923-o4fj8kx0 104 12 first first JJ cord-286923-o4fj8kx0 104 13 and and CC cord-286923-o4fj8kx0 104 14 short short JJ cord-286923-o4fj8kx0 104 15 lasting last VBG cord-286923-o4fj8kx0 104 16 repression repression NN cord-286923-o4fj8kx0 104 17 and and CC cord-286923-o4fj8kx0 104 18 long long JJ cord-286923-o4fj8kx0 104 19 lasting last VBG cord-286923-o4fj8kx0 104 20 induction induction NN cord-286923-o4fj8kx0 104 21 action action NN cord-286923-o4fj8kx0 104 22 ) ) -RRB- cord-286923-o4fj8kx0 104 23 [ [ -LRB- cord-286923-o4fj8kx0 104 24 47 47 CD cord-286923-o4fj8kx0 104 25 ] ] -RRB- cord-286923-o4fj8kx0 104 26 . . . cord-286923-o4fj8kx0 105 1 Furthermore furthermore RB cord-286923-o4fj8kx0 105 2 , , , cord-286923-o4fj8kx0 105 3 Vitamin vitamin NN cord-286923-o4fj8kx0 105 4 D d NN cord-286923-o4fj8kx0 105 5 is be VBZ cord-286923-o4fj8kx0 105 6 a a DT cord-286923-o4fj8kx0 105 7 potent potent JJ cord-286923-o4fj8kx0 105 8 suppressor suppressor NN cord-286923-o4fj8kx0 105 9 of of IN cord-286923-o4fj8kx0 105 10 IFNγ IFNγ NNS cord-286923-o4fj8kx0 105 11 - - HYPH cord-286923-o4fj8kx0 105 12 mediated mediate VBN cord-286923-o4fj8kx0 105 13 macrophage macrophage NN cord-286923-o4fj8kx0 105 14 activation activation NN cord-286923-o4fj8kx0 105 15 [ [ -LRB- cord-286923-o4fj8kx0 105 16 80 80 CD cord-286923-o4fj8kx0 105 17 ] ] -RRB- cord-286923-o4fj8kx0 105 18 , , , cord-286923-o4fj8kx0 105 19 which which WDT cord-286923-o4fj8kx0 105 20 all all PDT cord-286923-o4fj8kx0 105 21 these these DT cord-286923-o4fj8kx0 105 22 are be VBP cord-286923-o4fj8kx0 105 23 likely likely JJ cord-286923-o4fj8kx0 105 24 to to TO cord-286923-o4fj8kx0 105 25 be be VB cord-286923-o4fj8kx0 105 26 protective protective JJ cord-286923-o4fj8kx0 105 27 of of IN cord-286923-o4fj8kx0 105 28 the the DT cord-286923-o4fj8kx0 105 29 COVID-19 covid-19 JJ cord-286923-o4fj8kx0 105 30 severity severity NN cord-286923-o4fj8kx0 105 31 . . . cord-286923-o4fj8kx0 106 1 Till till IN cord-286923-o4fj8kx0 106 2 proved prove VBN cord-286923-o4fj8kx0 106 3 otherwise otherwise RB cord-286923-o4fj8kx0 106 4 , , , cord-286923-o4fj8kx0 106 5 the the DT cord-286923-o4fj8kx0 106 6 reduction reduction NN cord-286923-o4fj8kx0 106 7 of of IN cord-286923-o4fj8kx0 106 8 Covid-19 covid-19 JJ cord-286923-o4fj8kx0 106 9 severity severity NN cord-286923-o4fj8kx0 106 10 in in IN cord-286923-o4fj8kx0 106 11 Vitamin vitamin NN cord-286923-o4fj8kx0 106 12 D d NN cord-286923-o4fj8kx0 107 1 sufficient sufficient JJ cord-286923-o4fj8kx0 107 2 individuals individual NNS cord-286923-o4fj8kx0 107 3 is be VBZ cord-286923-o4fj8kx0 107 4 an an DT cord-286923-o4fj8kx0 107 5 interesting interesting JJ cord-286923-o4fj8kx0 107 6 observation observation NN cord-286923-o4fj8kx0 107 7 and and CC cord-286923-o4fj8kx0 107 8 another another DT cord-286923-o4fj8kx0 107 9 milestone milestone NN cord-286923-o4fj8kx0 107 10 to to TO cord-286923-o4fj8kx0 107 11 consolidate consolidate VB cord-286923-o4fj8kx0 107 12 the the DT cord-286923-o4fj8kx0 107 13 significance significance NN cord-286923-o4fj8kx0 107 14 of of IN cord-286923-o4fj8kx0 107 15 antiinflammatory antiinflammatory JJ cord-286923-o4fj8kx0 107 16 endogenous endogenous JJ cord-286923-o4fj8kx0 107 17 mediators mediator NNS cord-286923-o4fj8kx0 107 18 in in IN cord-286923-o4fj8kx0 107 19 the the DT cord-286923-o4fj8kx0 107 20 amelioration amelioration NN cord-286923-o4fj8kx0 107 21 of of IN cord-286923-o4fj8kx0 107 22 the the DT cord-286923-o4fj8kx0 107 23 COVID-19 covid-19 JJ cord-286923-o4fj8kx0 107 24 morbidity morbidity NN cord-286923-o4fj8kx0 107 25 and and CC cord-286923-o4fj8kx0 107 26 mortality mortality NN cord-286923-o4fj8kx0 107 27 . . . cord-286923-o4fj8kx0 108 1 This this DT cord-286923-o4fj8kx0 108 2 observation observation NN cord-286923-o4fj8kx0 108 3 may may MD cord-286923-o4fj8kx0 108 4 have have VB cord-286923-o4fj8kx0 108 5 as as RB cord-286923-o4fj8kx0 108 6 well well RB cord-286923-o4fj8kx0 108 7 programmatic programmatic JJ cord-286923-o4fj8kx0 108 8 implication implication NN cord-286923-o4fj8kx0 108 9 as as IN cord-286923-o4fj8kx0 108 10 the the DT cord-286923-o4fj8kx0 108 11 world world NN cord-286923-o4fj8kx0 108 12 is be VBZ cord-286923-o4fj8kx0 108 13 advocating advocate VBG cord-286923-o4fj8kx0 108 14 " " `` cord-286923-o4fj8kx0 108 15 stay stay VB cord-286923-o4fj8kx0 108 16 at at IN cord-286923-o4fj8kx0 108 17 home home NN cord-286923-o4fj8kx0 108 18 / / SYM cord-286923-o4fj8kx0 108 19 lockdown lockdown NN cord-286923-o4fj8kx0 108 20 " " `` cord-286923-o4fj8kx0 108 21 preventive preventive JJ cord-286923-o4fj8kx0 108 22 measures measure NNS cord-286923-o4fj8kx0 108 23 , , , cord-286923-o4fj8kx0 108 24 while while IN cord-286923-o4fj8kx0 108 25 physical physical JJ cord-286923-o4fj8kx0 108 26 distancing distancing NN cord-286923-o4fj8kx0 108 27 at at IN cord-286923-o4fj8kx0 108 28 outdoor outdoor NN cord-286923-o4fj8kx0 108 29 is be VBZ cord-286923-o4fj8kx0 108 30 probably probably RB cord-286923-o4fj8kx0 108 31 an an DT cord-286923-o4fj8kx0 108 32 appropriate appropriate JJ cord-286923-o4fj8kx0 108 33 decision decision NN cord-286923-o4fj8kx0 108 34 . . . cord-286923-o4fj8kx0 109 1 Vitamin vitamin NN cord-286923-o4fj8kx0 109 2 D d NN cord-286923-o4fj8kx0 109 3 deficiency deficiency NN cord-286923-o4fj8kx0 109 4 is be VBZ cord-286923-o4fj8kx0 109 5 associated associate VBN cord-286923-o4fj8kx0 109 6 with with IN cord-286923-o4fj8kx0 109 7 many many JJ cord-286923-o4fj8kx0 109 8 acute acute JJ cord-286923-o4fj8kx0 109 9 and and CC cord-286923-o4fj8kx0 109 10 chronic chronic JJ cord-286923-o4fj8kx0 109 11 inflammatory inflammatory JJ cord-286923-o4fj8kx0 109 12 diseases disease NNS cord-286923-o4fj8kx0 109 13 , , , cord-286923-o4fj8kx0 109 14 including include VBG cord-286923-o4fj8kx0 109 15 increased increase VBN cord-286923-o4fj8kx0 109 16 risk risk NN cord-286923-o4fj8kx0 109 17 of of IN cord-286923-o4fj8kx0 109 18 acute acute JJ cord-286923-o4fj8kx0 109 19 respiratory respiratory JJ cord-286923-o4fj8kx0 109 20 tract tract NN cord-286923-o4fj8kx0 109 21 infections infection NNS cord-286923-o4fj8kx0 109 22 , , , cord-286923-o4fj8kx0 109 23 tumorigenesis tumorigenesis NN cord-286923-o4fj8kx0 109 24 , , , cord-286923-o4fj8kx0 109 25 pulmonary pulmonary JJ cord-286923-o4fj8kx0 109 26 tuberculosis tuberculosis NN cord-286923-o4fj8kx0 109 27 , , , cord-286923-o4fj8kx0 109 28 atherosclerosis atherosclerosis NN cord-286923-o4fj8kx0 109 29 , , , cord-286923-o4fj8kx0 109 30 inflammatory inflammatory JJ cord-286923-o4fj8kx0 109 31 bowel bowel NN cord-286923-o4fj8kx0 109 32 disease disease NN cord-286923-o4fj8kx0 109 33 , , , cord-286923-o4fj8kx0 109 34 and and CC cord-286923-o4fj8kx0 109 35 rheumatoid rheumatoid NN cord-286923-o4fj8kx0 109 36 arthritis arthritis NN cord-286923-o4fj8kx0 109 37 [ [ -LRB- cord-286923-o4fj8kx0 109 38 81 81 CD cord-286923-o4fj8kx0 109 39 ] ] -RRB- cord-286923-o4fj8kx0 109 40 [ [ -LRB- cord-286923-o4fj8kx0 109 41 82 82 CD cord-286923-o4fj8kx0 109 42 ] ] -RRB- cord-286923-o4fj8kx0 109 43 [ [ -LRB- cord-286923-o4fj8kx0 109 44 83 83 CD cord-286923-o4fj8kx0 109 45 ] ] -RRB- cord-286923-o4fj8kx0 109 46 [ [ -LRB- cord-286923-o4fj8kx0 109 47 84 84 CD cord-286923-o4fj8kx0 109 48 ] ] -RRB- cord-286923-o4fj8kx0 109 49 [ [ -LRB- cord-286923-o4fj8kx0 109 50 85 85 CD cord-286923-o4fj8kx0 109 51 ] ] -RRB- cord-286923-o4fj8kx0 109 52 [ [ -LRB- cord-286923-o4fj8kx0 109 53 86 86 CD cord-286923-o4fj8kx0 109 54 ] ] -RRB- cord-286923-o4fj8kx0 109 55 . . . cord-286923-o4fj8kx0 110 1 What what WP cord-286923-o4fj8kx0 110 2 is be VBZ cord-286923-o4fj8kx0 110 3 special special JJ cord-286923-o4fj8kx0 110 4 for for IN cord-286923-o4fj8kx0 110 5 pregnancy pregnancy NN cord-286923-o4fj8kx0 110 6 ( ( -LRB- cord-286923-o4fj8kx0 110 7 specific specific JJ cord-286923-o4fj8kx0 110 8 to to IN cord-286923-o4fj8kx0 110 9 Vitamin vitamin NN cord-286923-o4fj8kx0 110 10 D d NN cord-286923-o4fj8kx0 110 11 ) ) -RRB- cord-286923-o4fj8kx0 110 12 is be VBZ cord-286923-o4fj8kx0 110 13 again again RB cord-286923-o4fj8kx0 110 14 its -PRON- PRP$ cord-286923-o4fj8kx0 110 15 additional additional JJ cord-286923-o4fj8kx0 110 16 production production NN cord-286923-o4fj8kx0 110 17 by by IN cord-286923-o4fj8kx0 110 18 the the DT cord-286923-o4fj8kx0 110 19 placenta placenta NN cord-286923-o4fj8kx0 110 20 . . . cord-286923-o4fj8kx0 111 1 According accord VBG cord-286923-o4fj8kx0 111 2 to to IN cord-286923-o4fj8kx0 111 3 one one CD cord-286923-o4fj8kx0 111 4 study study NN cord-286923-o4fj8kx0 111 5 , , , cord-286923-o4fj8kx0 111 6 the the DT cord-286923-o4fj8kx0 111 7 placenta placenta NN cord-286923-o4fj8kx0 111 8 and and CC cord-286923-o4fj8kx0 111 9 decidua decidua NN cord-286923-o4fj8kx0 111 10 ( ( -LRB- cord-286923-o4fj8kx0 111 11 mainly mainly RB cord-286923-o4fj8kx0 111 12 from from IN cord-286923-o4fj8kx0 111 13 macrophages macrophage NNS cord-286923-o4fj8kx0 111 14 , , , cord-286923-o4fj8kx0 111 15 uterine uterine JJ cord-286923-o4fj8kx0 111 16 natural natural JJ cord-286923-o4fj8kx0 111 17 killer killer NN cord-286923-o4fj8kx0 111 18 cells cell NNS cord-286923-o4fj8kx0 111 19 , , , cord-286923-o4fj8kx0 111 20 B b NN cord-286923-o4fj8kx0 111 21 cells cell NNS cord-286923-o4fj8kx0 111 22 , , , cord-286923-o4fj8kx0 111 23 T t NN cord-286923-o4fj8kx0 111 24 cells cell NNS cord-286923-o4fj8kx0 111 25 , , , cord-286923-o4fj8kx0 111 26 dendritic dendritic JJ cord-286923-o4fj8kx0 111 27 cells cell NNS cord-286923-o4fj8kx0 111 28 ) ) -RRB- cord-286923-o4fj8kx0 111 29 is be VBZ cord-286923-o4fj8kx0 111 30 the the DT cord-286923-o4fj8kx0 111 31 principal principal JJ cord-286923-o4fj8kx0 111 32 source source NN cord-286923-o4fj8kx0 111 33 of of IN cord-286923-o4fj8kx0 111 34 Vitamin vitamin NN cord-286923-o4fj8kx0 111 35 D d NN cord-286923-o4fj8kx0 111 36 outside outside IN cord-286923-o4fj8kx0 111 37 the the DT cord-286923-o4fj8kx0 111 38 renal renal JJ cord-286923-o4fj8kx0 111 39 site site NN cord-286923-o4fj8kx0 111 40 [ [ -LRB- cord-286923-o4fj8kx0 111 41 74 74 CD cord-286923-o4fj8kx0 111 42 , , , cord-286923-o4fj8kx0 111 43 87 87 CD cord-286923-o4fj8kx0 111 44 , , , cord-286923-o4fj8kx0 111 45 88 88 CD cord-286923-o4fj8kx0 111 46 ] ] -RRB- cord-286923-o4fj8kx0 111 47 , , , cord-286923-o4fj8kx0 111 48 probably probably RB cord-286923-o4fj8kx0 111 49 to to TO cord-286923-o4fj8kx0 111 50 meet meet VB cord-286923-o4fj8kx0 111 51 the the DT cord-286923-o4fj8kx0 111 52 high high JJ cord-286923-o4fj8kx0 111 53 demand demand NN cord-286923-o4fj8kx0 111 54 of of IN cord-286923-o4fj8kx0 111 55 it -PRON- PRP cord-286923-o4fj8kx0 111 56 for for IN cord-286923-o4fj8kx0 111 57 the the DT cord-286923-o4fj8kx0 111 58 fetal fetal JJ cord-286923-o4fj8kx0 111 59 physical physical JJ cord-286923-o4fj8kx0 111 60 growth growth NN cord-286923-o4fj8kx0 111 61 in in IN cord-286923-o4fj8kx0 111 62 the the DT cord-286923-o4fj8kx0 111 63 state state NN cord-286923-o4fj8kx0 111 64 of of IN cord-286923-o4fj8kx0 111 65 deficiency deficiency NN cord-286923-o4fj8kx0 111 66 . . . cord-286923-o4fj8kx0 112 1 The the DT cord-286923-o4fj8kx0 112 2 lower low JJR cord-286923-o4fj8kx0 112 3 level level NN cord-286923-o4fj8kx0 112 4 of of IN cord-286923-o4fj8kx0 112 5 IL-10 IL-10 NNP cord-286923-o4fj8kx0 112 6 and and CC cord-286923-o4fj8kx0 112 7 TGF TGF NNP cord-286923-o4fj8kx0 112 8 - - HYPH cord-286923-o4fj8kx0 112 9 β β NNP cord-286923-o4fj8kx0 112 10 in in IN cord-286923-o4fj8kx0 112 11 vitamin vitamin NN cord-286923-o4fj8kx0 112 12 D d NN cord-286923-o4fj8kx0 112 13 deficient deficient JJ cord-286923-o4fj8kx0 112 14 pregnant pregnant JJ cord-286923-o4fj8kx0 112 15 women woman NNS cord-286923-o4fj8kx0 112 16 is be VBZ cord-286923-o4fj8kx0 112 17 another another DT cord-286923-o4fj8kx0 112 18 evidence evidence NN cord-286923-o4fj8kx0 112 19 on on IN cord-286923-o4fj8kx0 112 20 its -PRON- PRP$ cord-286923-o4fj8kx0 112 21 significance significance NN cord-286923-o4fj8kx0 112 22 in in IN cord-286923-o4fj8kx0 112 23 upregulating upregulate VBG cord-286923-o4fj8kx0 112 24 effect effect NN cord-286923-o4fj8kx0 112 25 of of IN cord-286923-o4fj8kx0 112 26 the the DT cord-286923-o4fj8kx0 112 27 anti anti JJ cord-286923-o4fj8kx0 112 28 - - JJ cord-286923-o4fj8kx0 112 29 inflammatory inflammatory JJ cord-286923-o4fj8kx0 112 30 cytokines cytokine NNS cord-286923-o4fj8kx0 112 31 [ [ -LRB- cord-286923-o4fj8kx0 112 32 88 88 CD cord-286923-o4fj8kx0 112 33 ] ] -RRB- cord-286923-o4fj8kx0 112 34 . . . cord-286923-o4fj8kx0 113 1 Another another DT cord-286923-o4fj8kx0 113 2 study study NN cord-286923-o4fj8kx0 113 3 has have VBZ cord-286923-o4fj8kx0 113 4 also also RB cord-286923-o4fj8kx0 113 5 demonstrated demonstrate VBN cord-286923-o4fj8kx0 113 6 that that IN cord-286923-o4fj8kx0 113 7 the the DT cord-286923-o4fj8kx0 113 8 placenta placenta NN cord-286923-o4fj8kx0 113 9 , , , cord-286923-o4fj8kx0 113 10 decidua decidua NN cord-286923-o4fj8kx0 113 11 , , , cord-286923-o4fj8kx0 113 12 Therefore therefore RB cord-286923-o4fj8kx0 113 13 , , , cord-286923-o4fj8kx0 113 14 on on IN cord-286923-o4fj8kx0 113 15 top top NN cord-286923-o4fj8kx0 113 16 of of IN cord-286923-o4fj8kx0 113 17 its -PRON- PRP$ cord-286923-o4fj8kx0 113 18 tolerogenic tolerogenic JJ cord-286923-o4fj8kx0 113 19 effect effect NN cord-286923-o4fj8kx0 113 20 , , , cord-286923-o4fj8kx0 113 21 the the DT cord-286923-o4fj8kx0 113 22 immune immune JJ cord-286923-o4fj8kx0 113 23 modulating modulate VBG cord-286923-o4fj8kx0 113 24 action action NN cord-286923-o4fj8kx0 113 25 J J NNP cord-286923-o4fj8kx0 113 26 o o NN cord-286923-o4fj8kx0 113 27 u u NN cord-286923-o4fj8kx0 113 28 r r NN cord-286923-o4fj8kx0 113 29 n n NN cord-286923-o4fj8kx0 113 30 a a DT cord-286923-o4fj8kx0 113 31 l l NN cord-286923-o4fj8kx0 113 32 P p NN cord-286923-o4fj8kx0 113 33 r r NN cord-286923-o4fj8kx0 113 34 e e NN cord-286923-o4fj8kx0 113 35 -p -p NN cord-286923-o4fj8kx0 114 1 r r LS cord-286923-o4fj8kx0 115 1 o o UH cord-286923-o4fj8kx0 116 1 o o UH cord-286923-o4fj8kx0 116 2 f f NNP cord-286923-o4fj8kx0 116 3 is be VBZ cord-286923-o4fj8kx0 116 4 as as RB cord-286923-o4fj8kx0 116 5 well well RB cord-286923-o4fj8kx0 116 6 towards towards IN cord-286923-o4fj8kx0 116 7 infection infection NN cord-286923-o4fj8kx0 116 8 prevention prevention NN cord-286923-o4fj8kx0 116 9 , , , cord-286923-o4fj8kx0 116 10 which which WDT cord-286923-o4fj8kx0 116 11 is be VBZ cord-286923-o4fj8kx0 116 12 probably probably RB cord-286923-o4fj8kx0 116 13 an an DT cord-286923-o4fj8kx0 116 14 additional additional JJ cord-286923-o4fj8kx0 116 15 advantage advantage NN cord-286923-o4fj8kx0 116 16 for for IN cord-286923-o4fj8kx0 116 17 pregnant pregnant JJ cord-286923-o4fj8kx0 116 18 women woman NNS cord-286923-o4fj8kx0 116 19 to to TO cord-286923-o4fj8kx0 116 20 clear clear VB cord-286923-o4fj8kx0 116 21 SARS SARS NNP cord-286923-o4fj8kx0 116 22 CoV-2 CoV-2 NNP cord-286923-o4fj8kx0 116 23 before before IN cord-286923-o4fj8kx0 116 24 causing cause VBG cord-286923-o4fj8kx0 116 25 serious serious JJ cord-286923-o4fj8kx0 116 26 tissue tissue NN cord-286923-o4fj8kx0 116 27 damage damage NN cord-286923-o4fj8kx0 116 28 . . . cord-286923-o4fj8kx0 117 1 Pregnancy pregnancy NN cord-286923-o4fj8kx0 117 2 is be VBZ cord-286923-o4fj8kx0 117 3 also also RB cord-286923-o4fj8kx0 117 4 an an DT cord-286923-o4fj8kx0 117 5 advantage advantage NN cord-286923-o4fj8kx0 117 6 to to TO cord-286923-o4fj8kx0 117 7 get get VB cord-286923-o4fj8kx0 117 8 temporary temporary JJ cord-286923-o4fj8kx0 117 9 amelioration amelioration NN cord-286923-o4fj8kx0 117 10 from from IN cord-286923-o4fj8kx0 117 11 several several JJ cord-286923-o4fj8kx0 117 12 Th-1 Th-1 NNP cord-286923-o4fj8kx0 117 13 associated associate VBD cord-286923-o4fj8kx0 117 14 autoimmune autoimmune JJ cord-286923-o4fj8kx0 117 15 diseases disease NNS cord-286923-o4fj8kx0 117 16 ( ( -LRB- cord-286923-o4fj8kx0 117 17 including include VBG cord-286923-o4fj8kx0 117 18 multiple multiple JJ cord-286923-o4fj8kx0 117 19 sclerosis sclerosis NN cord-286923-o4fj8kx0 117 20 , , , cord-286923-o4fj8kx0 117 21 rheumatoid rheumatoid NN cord-286923-o4fj8kx0 117 22 arthritis arthritis NN cord-286923-o4fj8kx0 117 23 , , , cord-286923-o4fj8kx0 117 24 Graves Graves NNP cord-286923-o4fj8kx0 117 25 ' ' POS cord-286923-o4fj8kx0 117 26 disease disease NN cord-286923-o4fj8kx0 117 27 , , , cord-286923-o4fj8kx0 117 28 myasthenia myasthenia NN cord-286923-o4fj8kx0 117 29 gravis gravis NN cord-286923-o4fj8kx0 117 30 , , , cord-286923-o4fj8kx0 117 31 psoriasis psoriasis NN cord-286923-o4fj8kx0 117 32 , , , cord-286923-o4fj8kx0 117 33 uveitis uveitis NN cord-286923-o4fj8kx0 117 34 ) ) -RRB- cord-286923-o4fj8kx0 117 35 [ [ -LRB- cord-286923-o4fj8kx0 117 36 6 6 CD cord-286923-o4fj8kx0 117 37 , , , cord-286923-o4fj8kx0 117 38 7 7 CD cord-286923-o4fj8kx0 117 39 ] ] -RRB- cord-286923-o4fj8kx0 117 40 . . . cord-286923-o4fj8kx0 118 1 Almost almost RB cord-286923-o4fj8kx0 118 2 all all DT cord-286923-o4fj8kx0 118 3 pregnant pregnant JJ cord-286923-o4fj8kx0 118 4 women woman NNS cord-286923-o4fj8kx0 118 5 with with IN cord-286923-o4fj8kx0 118 6 these these DT cord-286923-o4fj8kx0 118 7 kind kind NN cord-286923-o4fj8kx0 118 8 of of IN cord-286923-o4fj8kx0 118 9 autoimmune autoimmune JJ cord-286923-o4fj8kx0 118 10 diseases disease NNS cord-286923-o4fj8kx0 118 11 have have VBP cord-286923-o4fj8kx0 118 12 exacerbation exacerbation NN cord-286923-o4fj8kx0 118 13 of of IN cord-286923-o4fj8kx0 118 14 symptoms symptom NNS cord-286923-o4fj8kx0 118 15 early early RB cord-286923-o4fj8kx0 118 16 in in IN cord-286923-o4fj8kx0 118 17 pregnancy pregnancy NN cord-286923-o4fj8kx0 118 18 ( ( -LRB- cord-286923-o4fj8kx0 118 19 while while IN cord-286923-o4fj8kx0 118 20 the the DT cord-286923-o4fj8kx0 118 21 Th-1 Th-1 NNP cord-286923-o4fj8kx0 118 22 immunity immunity NN cord-286923-o4fj8kx0 118 23 is be VBZ cord-286923-o4fj8kx0 118 24 dominant dominant JJ cord-286923-o4fj8kx0 118 25 ) ) -RRB- cord-286923-o4fj8kx0 118 26 and and CC cord-286923-o4fj8kx0 118 27 a a DT cord-286923-o4fj8kx0 118 28 remarkable remarkable JJ cord-286923-o4fj8kx0 118 29 remission remission NN cord-286923-o4fj8kx0 118 30 during during IN cord-286923-o4fj8kx0 118 31 the the DT cord-286923-o4fj8kx0 118 32 second second JJ cord-286923-o4fj8kx0 118 33 half half NN cord-286923-o4fj8kx0 118 34 of of IN cord-286923-o4fj8kx0 118 35 pregnancy pregnancy NN cord-286923-o4fj8kx0 118 36 . . . cord-286923-o4fj8kx0 119 1 When when WRB cord-286923-o4fj8kx0 119 2 the the DT cord-286923-o4fj8kx0 119 3 placental placental JJ cord-286923-o4fj8kx0 119 4 hormones hormone NNS cord-286923-o4fj8kx0 119 5 and and CC cord-286923-o4fj8kx0 119 6 the the DT cord-286923-o4fj8kx0 119 7 dominant dominant JJ cord-286923-o4fj8kx0 119 8 effect effect NN cord-286923-o4fj8kx0 119 9 of of IN cord-286923-o4fj8kx0 119 10 the the DT cord-286923-o4fj8kx0 119 11 anti anti JJ cord-286923-o4fj8kx0 119 12 - - JJ cord-286923-o4fj8kx0 119 13 inflammatory inflammatory JJ cord-286923-o4fj8kx0 119 14 immune immune JJ cord-286923-o4fj8kx0 119 15 response response NN cord-286923-o4fj8kx0 119 16 is be VBZ cord-286923-o4fj8kx0 119 17 relieved relieve VBN cord-286923-o4fj8kx0 119 18 during during IN cord-286923-o4fj8kx0 119 19 the the DT cord-286923-o4fj8kx0 119 20 peripartum peripartum NN cord-286923-o4fj8kx0 119 21 and and CC cord-286923-o4fj8kx0 119 22 postpartum postpartum NN cord-286923-o4fj8kx0 119 23 period period NN cord-286923-o4fj8kx0 119 24 , , , cord-286923-o4fj8kx0 119 25 there there EX cord-286923-o4fj8kx0 119 26 will will MD cord-286923-o4fj8kx0 119 27 be be VB cord-286923-o4fj8kx0 119 28 a a DT cord-286923-o4fj8kx0 119 29 rebound rebound NN cord-286923-o4fj8kx0 119 30 effect effect NN cord-286923-o4fj8kx0 119 31 of of IN cord-286923-o4fj8kx0 119 32 autoantibodies autoantibody NNS cord-286923-o4fj8kx0 119 33 and and CC cord-286923-o4fj8kx0 119 34 flare flare VB cord-286923-o4fj8kx0 119 35 up up IN cord-286923-o4fj8kx0 119 36 of of IN cord-286923-o4fj8kx0 119 37 the the DT cord-286923-o4fj8kx0 119 38 symptoms symptom NNS cord-286923-o4fj8kx0 119 39 . . . cord-286923-o4fj8kx0 120 1 The the DT cord-286923-o4fj8kx0 120 2 mechanism mechanism NN cord-286923-o4fj8kx0 120 3 for for IN cord-286923-o4fj8kx0 120 4 temporary temporary JJ cord-286923-o4fj8kx0 120 5 remission remission NN cord-286923-o4fj8kx0 120 6 of of IN cord-286923-o4fj8kx0 120 7 many many JJ cord-286923-o4fj8kx0 120 8 of of IN cord-286923-o4fj8kx0 120 9 the the DT cord-286923-o4fj8kx0 120 10 autoimmune autoimmune JJ cord-286923-o4fj8kx0 120 11 disease disease NN cord-286923-o4fj8kx0 120 12 symptoms symptom NNS cord-286923-o4fj8kx0 120 13 is be VBZ cord-286923-o4fj8kx0 120 14 not not RB cord-286923-o4fj8kx0 120 15 exactly exactly RB cord-286923-o4fj8kx0 120 16 known know VBN cord-286923-o4fj8kx0 120 17 ; ; : cord-286923-o4fj8kx0 120 18 the the DT cord-286923-o4fj8kx0 120 19 dominant dominant JJ cord-286923-o4fj8kx0 120 20 Th-2 Th-2 NNP cord-286923-o4fj8kx0 120 21 immunity immunity NN cord-286923-o4fj8kx0 120 22 and and CC cord-286923-o4fj8kx0 120 23 the the DT cord-286923-o4fj8kx0 120 24 collective collective JJ cord-286923-o4fj8kx0 120 25 effect effect NN cord-286923-o4fj8kx0 120 26 of of IN cord-286923-o4fj8kx0 120 27 the the DT cord-286923-o4fj8kx0 120 28 antiinflammatory antiinflammatory JJ cord-286923-o4fj8kx0 120 29 cytokines cytokine NNS cord-286923-o4fj8kx0 120 30 and and CC cord-286923-o4fj8kx0 120 31 hormones hormone NNS cord-286923-o4fj8kx0 120 32 is be VBZ cord-286923-o4fj8kx0 120 33 the the DT cord-286923-o4fj8kx0 120 34 most most RBS cord-286923-o4fj8kx0 120 35 probable probable JJ cord-286923-o4fj8kx0 120 36 explanation explanation NN cord-286923-o4fj8kx0 120 37 . . . cord-286923-o4fj8kx0 121 1 Despite despite IN cord-286923-o4fj8kx0 121 2 serious serious JJ cord-286923-o4fj8kx0 121 3 concern concern NN cord-286923-o4fj8kx0 121 4 for for IN cord-286923-o4fj8kx0 121 5 patients patient NNS cord-286923-o4fj8kx0 121 6 with with IN cord-286923-o4fj8kx0 121 7 autoimmune autoimmune JJ cord-286923-o4fj8kx0 121 8 disease disease NN cord-286923-o4fj8kx0 121 9 , , , cord-286923-o4fj8kx0 121 10 taking take VBG cord-286923-o4fj8kx0 121 11 their -PRON- PRP$ cord-286923-o4fj8kx0 121 12 immune immune JJ cord-286923-o4fj8kx0 121 13 suppression suppression NN cord-286923-o4fj8kx0 121 14 and and CC cord-286923-o4fj8kx0 121 15 medications medication NNS cord-286923-o4fj8kx0 121 16 , , , cord-286923-o4fj8kx0 121 17 at at IN cord-286923-o4fj8kx0 121 18 least least JJS cord-286923-o4fj8kx0 121 19 110 110 CD cord-286923-o4fj8kx0 121 20 individuals individual NNS cord-286923-o4fj8kx0 121 21 ( ( -LRB- cord-286923-o4fj8kx0 121 22 79 79 CD cord-286923-o4fj8kx0 121 23 % % NN cord-286923-o4fj8kx0 121 24 females female NNS cord-286923-o4fj8kx0 121 25 ) ) -RRB- cord-286923-o4fj8kx0 121 26 with with IN cord-286923-o4fj8kx0 121 27 rheumatoid rheumatoid NN cord-286923-o4fj8kx0 121 28 arthritis arthritis NN cord-286923-o4fj8kx0 121 29 and and CC cord-286923-o4fj8kx0 121 30 got get VBD cord-286923-o4fj8kx0 121 31 infected infect VBN cord-286923-o4fj8kx0 121 32 with with IN cord-286923-o4fj8kx0 121 33 SARS SARS NNP cord-286923-o4fj8kx0 121 34 CoV-2 CoV-2 NNP cord-286923-o4fj8kx0 121 35 ( ( -LRB- cord-286923-o4fj8kx0 121 36 from from IN cord-286923-o4fj8kx0 121 37 six six CD cord-286923-o4fj8kx0 121 38 continents continent NNS cord-286923-o4fj8kx0 121 39 ) ) -RRB- cord-286923-o4fj8kx0 121 40 were be VBD cord-286923-o4fj8kx0 121 41 not not RB cord-286923-o4fj8kx0 121 42 as as RB cord-286923-o4fj8kx0 121 43 such such JJ cord-286923-o4fj8kx0 121 44 at at IN cord-286923-o4fj8kx0 121 45 higher high JJR cord-286923-o4fj8kx0 121 46 risk risk NN cord-286923-o4fj8kx0 121 47 of of IN cord-286923-o4fj8kx0 121 48 mortality mortality NN cord-286923-o4fj8kx0 121 49 , , , cord-286923-o4fj8kx0 121 50 probably probably RB cord-286923-o4fj8kx0 121 51 as as IN cord-286923-o4fj8kx0 121 52 they -PRON- PRP cord-286923-o4fj8kx0 121 53 were be VBD cord-286923-o4fj8kx0 121 54 on on IN cord-286923-o4fj8kx0 121 55 anti anti JJ cord-286923-o4fj8kx0 121 56 - - JJ cord-286923-o4fj8kx0 121 57 inflammatory inflammatory JJ cord-286923-o4fj8kx0 121 58 medication medication NN cord-286923-o4fj8kx0 121 59 ; ; : cord-286923-o4fj8kx0 121 60 only only RB cord-286923-o4fj8kx0 121 61 6(5 6(5 CD cord-286923-o4fj8kx0 121 62 % % NN cord-286923-o4fj8kx0 121 63 ) ) -RRB- cord-286923-o4fj8kx0 121 64 persons person NNS cord-286923-o4fj8kx0 121 65 died die VBD cord-286923-o4fj8kx0 121 66 of of IN cord-286923-o4fj8kx0 121 67 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 121 68 [ [ -LRB- cord-286923-o4fj8kx0 121 69 89 89 CD cord-286923-o4fj8kx0 121 70 ] ] -RRB- cord-286923-o4fj8kx0 121 71 . . . cord-286923-o4fj8kx0 122 1 This this DT cord-286923-o4fj8kx0 122 2 small small JJ cord-286923-o4fj8kx0 122 3 data datum NNS cord-286923-o4fj8kx0 122 4 and and CC cord-286923-o4fj8kx0 122 5 the the DT cord-286923-o4fj8kx0 122 6 remission remission NN cord-286923-o4fj8kx0 122 7 of of IN cord-286923-o4fj8kx0 122 8 autoimmune autoimmune JJ cord-286923-o4fj8kx0 122 9 disease disease NN cord-286923-o4fj8kx0 122 10 symptoms symptom NNS cord-286923-o4fj8kx0 122 11 during during IN cord-286923-o4fj8kx0 122 12 pregnancy pregnancy NN cord-286923-o4fj8kx0 122 13 may may MD cord-286923-o4fj8kx0 122 14 still still RB cord-286923-o4fj8kx0 122 15 underscore underscore VB cord-286923-o4fj8kx0 122 16 how how WRB cord-286923-o4fj8kx0 122 17 important important JJ cord-286923-o4fj8kx0 122 18 the the DT cord-286923-o4fj8kx0 122 19 anti anti JJ cord-286923-o4fj8kx0 122 20 - - JJ cord-286923-o4fj8kx0 122 21 inflammatory inflammatory JJ cord-286923-o4fj8kx0 122 22 state state NN cord-286923-o4fj8kx0 122 23 is be VBZ cord-286923-o4fj8kx0 122 24 to to TO cord-286923-o4fj8kx0 122 25 reduce reduce VB cord-286923-o4fj8kx0 122 26 the the DT cord-286923-o4fj8kx0 122 27 risk risk NN cord-286923-o4fj8kx0 122 28 of of IN cord-286923-o4fj8kx0 122 29 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 122 30 . . . cord-286923-o4fj8kx0 123 1 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 123 2 has have VBZ cord-286923-o4fj8kx0 123 3 also also RB cord-286923-o4fj8kx0 123 4 some some DT cord-286923-o4fj8kx0 123 5 common common JJ cord-286923-o4fj8kx0 123 6 characteristics characteristic NNS cord-286923-o4fj8kx0 123 7 with with IN cord-286923-o4fj8kx0 123 8 systemic systemic JJ cord-286923-o4fj8kx0 123 9 sclerosis sclerosis NN cord-286923-o4fj8kx0 123 10 . . . cord-286923-o4fj8kx0 124 1 In in IN cord-286923-o4fj8kx0 124 2 both both DT cord-286923-o4fj8kx0 124 3 conditions condition NNS cord-286923-o4fj8kx0 124 4 , , , cord-286923-o4fj8kx0 124 5 the the DT cord-286923-o4fj8kx0 124 6 proinflammatory proinflammatory JJ cord-286923-o4fj8kx0 124 7 ( ( -LRB- cord-286923-o4fj8kx0 124 8 Th-1 Th-1 NNP cord-286923-o4fj8kx0 124 9 ) ) -RRB- cord-286923-o4fj8kx0 124 10 and and CC cord-286923-o4fj8kx0 124 11 ant ant JJ cord-286923-o4fj8kx0 124 12 - - HYPH cord-286923-o4fj8kx0 124 13 inflammatory inflammatory JJ cord-286923-o4fj8kx0 124 14 ( ( -LRB- cord-286923-o4fj8kx0 124 15 The-2 The-2 NNP cord-286923-o4fj8kx0 124 16 ) ) -RRB- cord-286923-o4fj8kx0 124 17 cytokines cytokine NNS cord-286923-o4fj8kx0 124 18 are be VBP cord-286923-o4fj8kx0 124 19 activated activate VBN cord-286923-o4fj8kx0 124 20 ; ; : cord-286923-o4fj8kx0 124 21 neither neither CC cord-286923-o4fj8kx0 124 22 statistically statistically RB cord-286923-o4fj8kx0 124 23 significant significant JJ cord-286923-o4fj8kx0 124 24 deterioration deterioration NN cord-286923-o4fj8kx0 124 25 nor nor CC cord-286923-o4fj8kx0 124 26 improvement improvement NN cord-286923-o4fj8kx0 124 27 was be VBD cord-286923-o4fj8kx0 124 28 observed observe VBN cord-286923-o4fj8kx0 124 29 during during IN cord-286923-o4fj8kx0 124 30 pregnancy pregnancy NN cord-286923-o4fj8kx0 124 31 [ [ -LRB- cord-286923-o4fj8kx0 124 32 90 90 CD cord-286923-o4fj8kx0 124 33 , , , cord-286923-o4fj8kx0 124 34 91 91 CD cord-286923-o4fj8kx0 124 35 ] ] -RRB- cord-286923-o4fj8kx0 124 36 ; ; : cord-286923-o4fj8kx0 124 37 the the DT cord-286923-o4fj8kx0 124 38 profibrotic profibrotic JJ cord-286923-o4fj8kx0 124 39 effect effect NN cord-286923-o4fj8kx0 124 40 of of IN cord-286923-o4fj8kx0 124 41 IL-4 IL-4 NNP cord-286923-o4fj8kx0 124 42 , , , cord-286923-o4fj8kx0 124 43 IL-6 IL-6 NNP cord-286923-o4fj8kx0 124 44 and and CC cord-286923-o4fj8kx0 124 45 TGF TGF NNP cord-286923-o4fj8kx0 124 46 - - HYPH cord-286923-o4fj8kx0 124 47 β β NNP cord-286923-o4fj8kx0 124 48 looks look VBZ cord-286923-o4fj8kx0 124 49 counterbalanced counterbalance VBN cord-286923-o4fj8kx0 124 50 by by IN cord-286923-o4fj8kx0 124 51 significantly significantly RB cord-286923-o4fj8kx0 124 52 increased increase VBN cord-286923-o4fj8kx0 124 53 IL-10 IL-10 NNP cord-286923-o4fj8kx0 124 54 . . . cord-286923-o4fj8kx0 125 1 The the DT cord-286923-o4fj8kx0 125 2 author author NN cord-286923-o4fj8kx0 125 3 surmises surmise VBZ cord-286923-o4fj8kx0 125 4 that that IN cord-286923-o4fj8kx0 125 5 pregnant pregnant JJ cord-286923-o4fj8kx0 125 6 women woman NNS cord-286923-o4fj8kx0 125 7 's 's POS cord-286923-o4fj8kx0 125 8 risk risk NN cord-286923-o4fj8kx0 125 9 of of IN cord-286923-o4fj8kx0 125 10 having have VBG cord-286923-o4fj8kx0 125 11 severe severe JJ cord-286923-o4fj8kx0 125 12 COVID-19 covid-19 NN cord-286923-o4fj8kx0 125 13 very very RB cord-286923-o4fj8kx0 125 14 early early RB cord-286923-o4fj8kx0 125 15 in in IN cord-286923-o4fj8kx0 125 16 gestation gestation NN cord-286923-o4fj8kx0 125 17 ( ( -LRB- cord-286923-o4fj8kx0 125 18 before before IN cord-286923-o4fj8kx0 125 19 the the DT cord-286923-o4fj8kx0 125 20 Th-2 Th-2 NNP cord-286923-o4fj8kx0 125 21 immunity immunity NN cord-286923-o4fj8kx0 125 22 and and CC cord-286923-o4fj8kx0 125 23 placental placental JJ cord-286923-o4fj8kx0 125 24 hormones hormone NNS cord-286923-o4fj8kx0 125 25 take take VBP cord-286923-o4fj8kx0 125 26 control control NN cord-286923-o4fj8kx0 125 27 ) ) -RRB- cord-286923-o4fj8kx0 125 28 and and CC cord-286923-o4fj8kx0 125 29 in in IN cord-286923-o4fj8kx0 125 30 the the DT cord-286923-o4fj8kx0 125 31 J J NNP cord-286923-o4fj8kx0 125 32 o o NN cord-286923-o4fj8kx0 125 33 u u NN cord-286923-o4fj8kx0 125 34 r r NN cord-286923-o4fj8kx0 125 35 n n NN cord-286923-o4fj8kx0 125 36 a a DT cord-286923-o4fj8kx0 125 37 l l NN cord-286923-o4fj8kx0 125 38 P p NN cord-286923-o4fj8kx0 125 39 r r NN cord-286923-o4fj8kx0 125 40 e e NN cord-286923-o4fj8kx0 126 1 -p -p NNP cord-286923-o4fj8kx0 126 2 r r NN cord-286923-o4fj8kx0 126 3 o o NN cord-286923-o4fj8kx0 126 4 o o NN cord-286923-o4fj8kx0 127 1 f f LS cord-286923-o4fj8kx0 127 2 postpartum postpartum NN cord-286923-o4fj8kx0 127 3 period period NN cord-286923-o4fj8kx0 127 4 may may MD cord-286923-o4fj8kx0 127 5 not not RB cord-286923-o4fj8kx0 127 6 be be VB cord-286923-o4fj8kx0 127 7 different different JJ cord-286923-o4fj8kx0 127 8 from from IN cord-286923-o4fj8kx0 127 9 the the DT cord-286923-o4fj8kx0 127 10 non non JJ cord-286923-o4fj8kx0 127 11 - - JJ cord-286923-o4fj8kx0 127 12 pregnant pregnant JJ cord-286923-o4fj8kx0 127 13 population population NN cord-286923-o4fj8kx0 127 14 . . . cord-286923-o4fj8kx0 128 1 Given give VBN cord-286923-o4fj8kx0 128 2 the the DT cord-286923-o4fj8kx0 128 3 limited limited JJ cord-286923-o4fj8kx0 128 4 data datum NNS cord-286923-o4fj8kx0 128 5 on on IN cord-286923-o4fj8kx0 128 6 this this DT cord-286923-o4fj8kx0 128 7 aspect aspect NN cord-286923-o4fj8kx0 128 8 , , , cord-286923-o4fj8kx0 128 9 and and CC cord-286923-o4fj8kx0 128 10 the the DT cord-286923-o4fj8kx0 128 11 immunological immunological JJ cord-286923-o4fj8kx0 128 12 and and CC cord-286923-o4fj8kx0 128 13 hormonal hormonal JJ cord-286923-o4fj8kx0 128 14 destabilization destabilization NN cord-286923-o4fj8kx0 128 15 during during IN cord-286923-o4fj8kx0 128 16 postpartum postpartum NN cord-286923-o4fj8kx0 128 17 period period NN cord-286923-o4fj8kx0 128 18 as as IN cord-286923-o4fj8kx0 128 19 transiting transit VBG cord-286923-o4fj8kx0 128 20 from from IN cord-286923-o4fj8kx0 128 21 pregnancy pregnancy NN cord-286923-o4fj8kx0 128 22 to to IN cord-286923-o4fj8kx0 128 23 non non JJ cord-286923-o4fj8kx0 128 24 - - JJ cord-286923-o4fj8kx0 128 25 pregnancy pregnancy JJ cord-286923-o4fj8kx0 128 26 state state NN cord-286923-o4fj8kx0 128 27 , , , cord-286923-o4fj8kx0 128 28 the the DT cord-286923-o4fj8kx0 128 29 severity severity NN cord-286923-o4fj8kx0 128 30 of of IN cord-286923-o4fj8kx0 128 31 and and CC cord-286923-o4fj8kx0 128 32 mortality mortality NN cord-286923-o4fj8kx0 128 33 due due IN cord-286923-o4fj8kx0 128 34 to to IN cord-286923-o4fj8kx0 128 35 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 128 36 may may MD cord-286923-o4fj8kx0 128 37 be be VB cord-286923-o4fj8kx0 128 38 higher high JJR cord-286923-o4fj8kx0 128 39 than than IN cord-286923-o4fj8kx0 128 40 the the DT cord-286923-o4fj8kx0 128 41 pregnancy pregnancy NN cord-286923-o4fj8kx0 128 42 period period NN cord-286923-o4fj8kx0 128 43 . . . cord-286923-o4fj8kx0 129 1 As as IN cord-286923-o4fj8kx0 129 2 exaggerated exaggerated JJ cord-286923-o4fj8kx0 129 3 chemokine chemokine NN cord-286923-o4fj8kx0 129 4 directed direct VBN cord-286923-o4fj8kx0 129 5 immunologic immunologic JJ cord-286923-o4fj8kx0 129 6 response response NN cord-286923-o4fj8kx0 129 7 can can MD cord-286923-o4fj8kx0 129 8 be be VB cord-286923-o4fj8kx0 129 9 diseases disease NNS cord-286923-o4fj8kx0 129 10 conditions condition NNS cord-286923-o4fj8kx0 129 11 in in IN cord-286923-o4fj8kx0 129 12 non non JJ cord-286923-o4fj8kx0 129 13 - - JJ cord-286923-o4fj8kx0 129 14 pregnant pregnant JJ cord-286923-o4fj8kx0 129 15 women woman NNS cord-286923-o4fj8kx0 129 16 ( ( -LRB- cord-286923-o4fj8kx0 129 17 autoimmune autoimmune JJ cord-286923-o4fj8kx0 129 18 disease disease NN cord-286923-o4fj8kx0 129 19 , , , cord-286923-o4fj8kx0 129 20 chronic chronic JJ cord-286923-o4fj8kx0 129 21 inflammatory inflammatory JJ cord-286923-o4fj8kx0 129 22 disease disease NN cord-286923-o4fj8kx0 129 23 , , , cord-286923-o4fj8kx0 129 24 allergic allergic JJ cord-286923-o4fj8kx0 129 25 reaction reaction NN cord-286923-o4fj8kx0 129 26 , , , cord-286923-o4fj8kx0 129 27 atherosclerosis atherosclerosis NN cord-286923-o4fj8kx0 129 28 , , , cord-286923-o4fj8kx0 129 29 cancer cancer NN cord-286923-o4fj8kx0 129 30 , , , cord-286923-o4fj8kx0 129 31 and and CC cord-286923-o4fj8kx0 129 32 the the DT cord-286923-o4fj8kx0 129 33 like like JJ cord-286923-o4fj8kx0 129 34 ) ) -RRB- cord-286923-o4fj8kx0 129 35 , , , cord-286923-o4fj8kx0 129 36 unilateral unilateral JJ cord-286923-o4fj8kx0 129 37 suppressed suppress VBN cord-286923-o4fj8kx0 129 38 Th-1 Th-1 NNP cord-286923-o4fj8kx0 129 39 immunity immunity NN cord-286923-o4fj8kx0 129 40 during during IN cord-286923-o4fj8kx0 129 41 pregnancy pregnancy NN cord-286923-o4fj8kx0 130 1 is be VBZ cord-286923-o4fj8kx0 130 2 an an DT cord-286923-o4fj8kx0 130 3 advantage advantage NN cord-286923-o4fj8kx0 130 4 for for IN cord-286923-o4fj8kx0 130 5 the the DT cord-286923-o4fj8kx0 130 6 fetus fetus NN cord-286923-o4fj8kx0 130 7 's 's POS cord-286923-o4fj8kx0 130 8 intrauterine intrauterine JJ cord-286923-o4fj8kx0 130 9 survival survival NN cord-286923-o4fj8kx0 130 10 and and CC cord-286923-o4fj8kx0 130 11 symptom symptom NN cord-286923-o4fj8kx0 130 12 free free JJ cord-286923-o4fj8kx0 130 13 life life NN cord-286923-o4fj8kx0 130 14 of of IN cord-286923-o4fj8kx0 130 15 the the DT cord-286923-o4fj8kx0 130 16 mother mother NN cord-286923-o4fj8kx0 130 17 from from IN cord-286923-o4fj8kx0 130 18 the the DT cord-286923-o4fj8kx0 130 19 majority majority NN cord-286923-o4fj8kx0 130 20 of of IN cord-286923-o4fj8kx0 130 21 the the DT cord-286923-o4fj8kx0 130 22 autoimmune autoimmune JJ cord-286923-o4fj8kx0 130 23 diseases disease NNS cord-286923-o4fj8kx0 130 24 and and CC cord-286923-o4fj8kx0 130 25 less less RBR cord-286923-o4fj8kx0 130 26 severe severe JJ cord-286923-o4fj8kx0 130 27 disease disease NN cord-286923-o4fj8kx0 130 28 of of IN cord-286923-o4fj8kx0 130 29 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 130 30 in in IN cord-286923-o4fj8kx0 130 31 most most JJS cord-286923-o4fj8kx0 130 32 of of IN cord-286923-o4fj8kx0 130 33 pregnant pregnant JJ cord-286923-o4fj8kx0 130 34 women woman NNS cord-286923-o4fj8kx0 130 35 . . . cord-286923-o4fj8kx0 131 1 Therefore therefore RB cord-286923-o4fj8kx0 131 2 , , , cord-286923-o4fj8kx0 131 3 what what WP cord-286923-o4fj8kx0 131 4 looks look VBZ cord-286923-o4fj8kx0 131 5 in in IN cord-286923-o4fj8kx0 131 6 common common JJ cord-286923-o4fj8kx0 131 7 for for IN cord-286923-o4fj8kx0 131 8 autoimmune autoimmune JJ cord-286923-o4fj8kx0 131 9 disease disease NN cord-286923-o4fj8kx0 131 10 and and CC cord-286923-o4fj8kx0 131 11 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 131 12 is be VBZ cord-286923-o4fj8kx0 131 13 the the DT cord-286923-o4fj8kx0 131 14 less less JJR cord-286923-o4fj8kx0 131 15 risk risk NN cord-286923-o4fj8kx0 131 16 of of IN cord-286923-o4fj8kx0 131 17 severity severity NN cord-286923-o4fj8kx0 131 18 during during IN cord-286923-o4fj8kx0 131 19 pregnancy pregnancy NN cord-286923-o4fj8kx0 131 20 , , , cord-286923-o4fj8kx0 131 21 probably probably RB cord-286923-o4fj8kx0 131 22 due due JJ cord-286923-o4fj8kx0 131 23 to to IN cord-286923-o4fj8kx0 131 24 similar similar JJ cord-286923-o4fj8kx0 131 25 immune immune JJ cord-286923-o4fj8kx0 131 26 modulating modulate VBG cord-286923-o4fj8kx0 131 27 action action NN cord-286923-o4fj8kx0 131 28 of of IN cord-286923-o4fj8kx0 131 29 the the DT cord-286923-o4fj8kx0 131 30 pregnancy pregnancy NN cord-286923-o4fj8kx0 131 31 . . . cord-286923-o4fj8kx0 132 1 First first RB cord-286923-o4fj8kx0 132 2 of of IN cord-286923-o4fj8kx0 132 3 all all DT cord-286923-o4fj8kx0 132 4 , , , cord-286923-o4fj8kx0 132 5 assessing assess VBG cord-286923-o4fj8kx0 132 6 the the DT cord-286923-o4fj8kx0 132 7 cytokine cytokine NN cord-286923-o4fj8kx0 132 8 profile profile NN cord-286923-o4fj8kx0 132 9 and and CC cord-286923-o4fj8kx0 132 10 determining determine VBG cord-286923-o4fj8kx0 132 11 the the DT cord-286923-o4fj8kx0 132 12 Vitamin vitamin NN cord-286923-o4fj8kx0 132 13 D d NN cord-286923-o4fj8kx0 132 14 level level NN cord-286923-o4fj8kx0 132 15 of of IN cord-286923-o4fj8kx0 132 16 pregnant pregnant JJ cord-286923-o4fj8kx0 132 17 women woman NNS cord-286923-o4fj8kx0 132 18 based base VBN cord-286923-o4fj8kx0 132 19 on on IN cord-286923-o4fj8kx0 132 20 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 132 21 illness illness NN cord-286923-o4fj8kx0 132 22 severity severity NN cord-286923-o4fj8kx0 132 23 is be VBZ cord-286923-o4fj8kx0 132 24 critically critically RB cord-286923-o4fj8kx0 132 25 important important JJ cord-286923-o4fj8kx0 132 26 to to TO cord-286923-o4fj8kx0 132 27 verify verify VB cord-286923-o4fj8kx0 132 28 the the DT cord-286923-o4fj8kx0 132 29 postulated postulate VBN cord-286923-o4fj8kx0 132 30 mechanisms mechanism NNS cord-286923-o4fj8kx0 132 31 . . . cord-286923-o4fj8kx0 133 1 Several several JJ cord-286923-o4fj8kx0 133 2 of of IN cord-286923-o4fj8kx0 133 3 ongoing ongoing JJ cord-286923-o4fj8kx0 133 4 trials trial NNS cord-286923-o4fj8kx0 133 5 aimed aim VBN cord-286923-o4fj8kx0 133 6 to to TO cord-286923-o4fj8kx0 133 7 reverse reverse VB cord-286923-o4fj8kx0 133 8 the the DT cord-286923-o4fj8kx0 133 9 overactive overactive JJ cord-286923-o4fj8kx0 133 10 cytokine cytokine NN cord-286923-o4fj8kx0 133 11 response response NN cord-286923-o4fj8kx0 133 12 with with IN cord-286923-o4fj8kx0 133 13 exogenous exogenous JJ cord-286923-o4fj8kx0 133 14 immunomodulators immunomodulator NNS cord-286923-o4fj8kx0 133 15 . . . cord-286923-o4fj8kx0 134 1 Herein herein RB cord-286923-o4fj8kx0 134 2 , , , cord-286923-o4fj8kx0 134 3 proposed propose VBN cord-286923-o4fj8kx0 134 4 clinical clinical JJ cord-286923-o4fj8kx0 134 5 trial trial NN cord-286923-o4fj8kx0 134 6 is be VBZ cord-286923-o4fj8kx0 134 7 intended intend VBN cord-286923-o4fj8kx0 134 8 to to TO cord-286923-o4fj8kx0 134 9 treat treat VB cord-286923-o4fj8kx0 134 10 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 134 11 in in IN cord-286923-o4fj8kx0 134 12 its -PRON- PRP$ cord-286923-o4fj8kx0 134 13 early early JJ cord-286923-o4fj8kx0 134 14 stage stage NN cord-286923-o4fj8kx0 134 15 with with IN cord-286923-o4fj8kx0 134 16 hormonal hormonal JJ cord-286923-o4fj8kx0 134 17 analogues analogue NNS cord-286923-o4fj8kx0 134 18 and and CC cord-286923-o4fj8kx0 134 19 anticoagulants anticoagulant NNS cord-286923-o4fj8kx0 134 20 . . . cord-286923-o4fj8kx0 135 1 The the DT cord-286923-o4fj8kx0 135 2 author author NN cord-286923-o4fj8kx0 135 3 postulates postulate VBZ cord-286923-o4fj8kx0 135 4 that that IN cord-286923-o4fj8kx0 135 5 as as IN cord-286923-o4fj8kx0 135 6 pregnancy pregnancy NN cord-286923-o4fj8kx0 135 7 develops develop VBZ cord-286923-o4fj8kx0 135 8 a a DT cord-286923-o4fj8kx0 135 9 natural natural JJ cord-286923-o4fj8kx0 135 10 way way NN cord-286923-o4fj8kx0 135 11 of of IN cord-286923-o4fj8kx0 135 12 defense defense NN cord-286923-o4fj8kx0 135 13 mechanism mechanism NN cord-286923-o4fj8kx0 135 14 against against IN cord-286923-o4fj8kx0 135 15 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 135 16 , , , cord-286923-o4fj8kx0 135 17 the the DT cord-286923-o4fj8kx0 135 18 prevention prevention NN cord-286923-o4fj8kx0 135 19 of of IN cord-286923-o4fj8kx0 135 20 severe severe JJ cord-286923-o4fj8kx0 135 21 complications complication NNS cord-286923-o4fj8kx0 135 22 of of IN cord-286923-o4fj8kx0 135 23 this this DT cord-286923-o4fj8kx0 135 24 disease disease NN cord-286923-o4fj8kx0 135 25 can can MD cord-286923-o4fj8kx0 135 26 be be VB cord-286923-o4fj8kx0 135 27 sought seek VBN cord-286923-o4fj8kx0 135 28 by by IN cord-286923-o4fj8kx0 135 29 boosting boost VBG cord-286923-o4fj8kx0 135 30 the the DT cord-286923-o4fj8kx0 135 31 naturally naturally RB cord-286923-o4fj8kx0 135 32 existing exist VBG cord-286923-o4fj8kx0 135 33 protective protective JJ cord-286923-o4fj8kx0 135 34 hormones hormone NNS cord-286923-o4fj8kx0 135 35 and and CC cord-286923-o4fj8kx0 135 36 cytokines cytokine NNS cord-286923-o4fj8kx0 135 37 . . . cord-286923-o4fj8kx0 136 1 Some some DT cord-286923-o4fj8kx0 136 2 authors author NNS cord-286923-o4fj8kx0 136 3 recommended recommend VBD cord-286923-o4fj8kx0 136 4 administering administer VBG cord-286923-o4fj8kx0 136 5 anticoagulant anticoagulant NN cord-286923-o4fj8kx0 136 6 for for IN cord-286923-o4fj8kx0 136 7 critically critically RB cord-286923-o4fj8kx0 136 8 ill ill JJ cord-286923-o4fj8kx0 136 9 patients patient NNS cord-286923-o4fj8kx0 136 10 with with IN cord-286923-o4fj8kx0 136 11 elevated elevated JJ cord-286923-o4fj8kx0 136 12 d d NN cord-286923-o4fj8kx0 136 13 - - : cord-286923-o4fj8kx0 136 14 dimer dimer JJ cord-286923-o4fj8kx0 136 15 [ [ -LRB- cord-286923-o4fj8kx0 136 16 92 92 CD cord-286923-o4fj8kx0 136 17 ] ] -RRB- cord-286923-o4fj8kx0 136 18 . . . cord-286923-o4fj8kx0 137 1 Extending extend VBG cord-286923-o4fj8kx0 137 2 this this DT cord-286923-o4fj8kx0 137 3 recommendation recommendation NN cord-286923-o4fj8kx0 137 4 to to TO cord-286923-o4fj8kx0 137 5 be be VB cord-286923-o4fj8kx0 137 6 even even RB cord-286923-o4fj8kx0 137 7 earlier early RBR cord-286923-o4fj8kx0 137 8 for for IN cord-286923-o4fj8kx0 137 9 seriously seriously RB cord-286923-o4fj8kx0 137 10 symptomatic symptomatic JJ cord-286923-o4fj8kx0 137 11 patient patient NN cord-286923-o4fj8kx0 137 12 ( ( -LRB- cord-286923-o4fj8kx0 137 13 with with IN cord-286923-o4fj8kx0 137 14 high high JJ cord-286923-o4fj8kx0 137 15 grade grade NN cord-286923-o4fj8kx0 137 16 fever fever NN cord-286923-o4fj8kx0 137 17 and and CC cord-286923-o4fj8kx0 137 18 persistent persistent JJ cord-286923-o4fj8kx0 137 19 dry dry JJ cord-286923-o4fj8kx0 137 20 cough cough NN cord-286923-o4fj8kx0 137 21 ) ) -RRB- cord-286923-o4fj8kx0 137 22 may may MD cord-286923-o4fj8kx0 137 23 have have VB cord-286923-o4fj8kx0 137 24 better well JJR cord-286923-o4fj8kx0 137 25 outcomes outcome NNS cord-286923-o4fj8kx0 137 26 . . . cord-286923-o4fj8kx0 138 1 It -PRON- PRP cord-286923-o4fj8kx0 138 2 is be VBZ cord-286923-o4fj8kx0 138 3 noted note VBN cord-286923-o4fj8kx0 138 4 that that IN cord-286923-o4fj8kx0 138 5 a a DT cord-286923-o4fj8kx0 138 6 randomized randomized JJ cord-286923-o4fj8kx0 138 7 clinical clinical JJ cord-286923-o4fj8kx0 138 8 trial trial NN cord-286923-o4fj8kx0 138 9 on on IN cord-286923-o4fj8kx0 138 10 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 138 11 is be VBZ cord-286923-o4fj8kx0 138 12 planned plan VBN cord-286923-o4fj8kx0 138 13 with with IN cord-286923-o4fj8kx0 138 14 Vitamin vitamin NN cord-286923-o4fj8kx0 138 15 D d NN cord-286923-o4fj8kx0 138 16 [ [ -LRB- cord-286923-o4fj8kx0 138 17 75 75 CD cord-286923-o4fj8kx0 138 18 ] ] -RRB- cord-286923-o4fj8kx0 138 19 . . . cord-286923-o4fj8kx0 139 1 On on IN cord-286923-o4fj8kx0 139 2 top top NN cord-286923-o4fj8kx0 139 3 of of IN cord-286923-o4fj8kx0 139 4 administering administer VBG cord-286923-o4fj8kx0 139 5 antibiotic antibiotic JJ cord-286923-o4fj8kx0 139 6 and and CC cord-286923-o4fj8kx0 139 7 anti anti JJ cord-286923-o4fj8kx0 139 8 - - JJ cord-286923-o4fj8kx0 139 9 inflammatory inflammatory JJ cord-286923-o4fj8kx0 139 10 agents agent NNS cord-286923-o4fj8kx0 139 11 for for IN cord-286923-o4fj8kx0 139 12 all all DT cord-286923-o4fj8kx0 139 13 with with IN cord-286923-o4fj8kx0 139 14 high high JJ cord-286923-o4fj8kx0 139 15 grade grade NN cord-286923-o4fj8kx0 139 16 fever fever NN cord-286923-o4fj8kx0 139 17 , , , cord-286923-o4fj8kx0 139 18 the the DT cord-286923-o4fj8kx0 139 19 clinical clinical JJ cord-286923-o4fj8kx0 139 20 trial trial NN cord-286923-o4fj8kx0 139 21 arms arm NNS cord-286923-o4fj8kx0 139 22 the the DT cord-286923-o4fj8kx0 139 23 author author NN cord-286923-o4fj8kx0 139 24 recommending recommend VBG cord-286923-o4fj8kx0 139 25 for for IN cord-286923-o4fj8kx0 139 26 non non JJ cord-286923-o4fj8kx0 139 27 - - JJ cord-286923-o4fj8kx0 139 28 pregnant pregnant JJ cord-286923-o4fj8kx0 139 29 COVID-19 covid-19 JJ cord-286923-o4fj8kx0 139 30 patients patient NNS cord-286923-o4fj8kx0 139 31 are be VBP cord-286923-o4fj8kx0 139 32 as as IN cord-286923-o4fj8kx0 139 33 follows follow VBZ cord-286923-o4fj8kx0 139 34 . . . cord-286923-o4fj8kx0 139 35 _SP cord-286923-o4fj8kx0 140 1 World World NNP cord-286923-o4fj8kx0 140 2 Health Health NNP cord-286923-o4fj8kx0 140 3 Organization Organization NNP cord-286923-o4fj8kx0 140 4 , , , cord-286923-o4fj8kx0 140 5 WHO who WP cord-286923-o4fj8kx0 140 6 Timeline Timeline NNP cord-286923-o4fj8kx0 140 7 COVID-19 covid-19 VBP cord-286923-o4fj8kx0 140 8 Viral viral JJ cord-286923-o4fj8kx0 140 9 infections infection NNS cord-286923-o4fj8kx0 140 10 during during IN cord-286923-o4fj8kx0 140 11 pregnancy pregnancy NN cord-286923-o4fj8kx0 140 12 Pregnancy pregnancy NN cord-286923-o4fj8kx0 140 13 and and CC cord-286923-o4fj8kx0 141 1 pregnancy pregnancy NN cord-286923-o4fj8kx0 141 2 - - HYPH cord-286923-o4fj8kx0 141 3 associated associate VBN cord-286923-o4fj8kx0 141 4 hormones hormone NNS cord-286923-o4fj8kx0 141 5 alter alter VBP cord-286923-o4fj8kx0 141 6 immune immune JJ cord-286923-o4fj8kx0 141 7 responses response NNS cord-286923-o4fj8kx0 141 8 and and CC cord-286923-o4fj8kx0 141 9 disease disease NN cord-286923-o4fj8kx0 141 10 pathogenesis pathogenesis NN cord-286923-o4fj8kx0 141 11 Progesterone Progesterone NNP cord-286923-o4fj8kx0 141 12 - - HYPH cord-286923-o4fj8kx0 141 13 Related relate VBN cord-286923-o4fj8kx0 141 14 Immune Immune NNP cord-286923-o4fj8kx0 141 15 Modulation modulation NN cord-286923-o4fj8kx0 141 16 of of IN cord-286923-o4fj8kx0 141 17 Pregnancy Pregnancy NNP cord-286923-o4fj8kx0 141 18 and and CC cord-286923-o4fj8kx0 141 19 Labor Labor NNP cord-286923-o4fj8kx0 142 1 How how WRB cord-286923-o4fj8kx0 142 2 pregnancy pregnancy NN cord-286923-o4fj8kx0 142 3 can can MD cord-286923-o4fj8kx0 142 4 affect affect VB cord-286923-o4fj8kx0 142 5 autoimmune autoimmune JJ cord-286923-o4fj8kx0 142 6 diseases disease NNS cord-286923-o4fj8kx0 142 7 progression progression NN cord-286923-o4fj8kx0 142 8 ? ? . cord-286923-o4fj8kx0 143 1 Coronavirus Coronavirus NNP cord-286923-o4fj8kx0 143 2 Disease Disease NNP cord-286923-o4fj8kx0 143 3 2019 2019 CD cord-286923-o4fj8kx0 143 4 ( ( -LRB- cord-286923-o4fj8kx0 143 5 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 143 6 ) ) -RRB- cord-286923-o4fj8kx0 143 7 and and CC cord-286923-o4fj8kx0 143 8 pregnancy pregnancy NN cord-286923-o4fj8kx0 143 9 : : : cord-286923-o4fj8kx0 144 1 what what WP cord-286923-o4fj8kx0 144 2 obstetricians obstetrician NNS cord-286923-o4fj8kx0 144 3 need need VBP cord-286923-o4fj8kx0 144 4 to to TO cord-286923-o4fj8kx0 144 5 know know VB cord-286923-o4fj8kx0 144 6 SARS SARS NNP cord-286923-o4fj8kx0 144 7 - - HYPH cord-286923-o4fj8kx0 144 8 CoV-2 CoV-2 NNP cord-286923-o4fj8kx0 144 9 A a DT cord-286923-o4fj8kx0 144 10 large large JJ cord-286923-o4fj8kx0 144 11 outbreak outbreak NN cord-286923-o4fj8kx0 144 12 of of IN cord-286923-o4fj8kx0 144 13 hepatitis hepatitis NN cord-286923-o4fj8kx0 144 14 E E NNP cord-286923-o4fj8kx0 144 15 among among IN cord-286923-o4fj8kx0 144 16 a a DT cord-286923-o4fj8kx0 144 17 displaced displace VBN cord-286923-o4fj8kx0 144 18 population population NN cord-286923-o4fj8kx0 144 19 in in IN cord-286923-o4fj8kx0 144 20 Darfur Darfur NNP cord-286923-o4fj8kx0 144 21 , , , cord-286923-o4fj8kx0 144 22 Sudan Sudan NNP cord-286923-o4fj8kx0 144 23 , , , cord-286923-o4fj8kx0 144 24 2004 2004 CD cord-286923-o4fj8kx0 144 25 : : : cord-286923-o4fj8kx0 144 26 the the DT cord-286923-o4fj8kx0 144 27 role role NN cord-286923-o4fj8kx0 144 28 of of IN cord-286923-o4fj8kx0 144 29 water water NN cord-286923-o4fj8kx0 144 30 treatment treatment NN cord-286923-o4fj8kx0 144 31 methods method NNS cord-286923-o4fj8kx0 144 32 An an DT cord-286923-o4fj8kx0 144 33 outbreak outbreak NN cord-286923-o4fj8kx0 144 34 of of IN cord-286923-o4fj8kx0 144 35 hepatitis hepatitis NN cord-286923-o4fj8kx0 144 36 E e NN cord-286923-o4fj8kx0 144 37 and and CC cord-286923-o4fj8kx0 144 38 high high JJ cord-286923-o4fj8kx0 144 39 maternal maternal JJ cord-286923-o4fj8kx0 144 40 mortality mortality NN cord-286923-o4fj8kx0 144 41 at at IN cord-286923-o4fj8kx0 144 42 Port Port NNP cord-286923-o4fj8kx0 144 43 Sudan Sudan NNP cord-286923-o4fj8kx0 144 44 , , , cord-286923-o4fj8kx0 144 45 Eastern Eastern NNP cord-286923-o4fj8kx0 144 46 Sudan Sudan NNP cord-286923-o4fj8kx0 144 47 Severe severe JJ cord-286923-o4fj8kx0 145 1 2009 2009 CD cord-286923-o4fj8kx0 145 2 H1N1 H1N1 NNP cord-286923-o4fj8kx0 145 3 Influenza Influenza NNP cord-286923-o4fj8kx0 145 4 in in IN cord-286923-o4fj8kx0 145 5 Pregnant Pregnant NNP cord-286923-o4fj8kx0 145 6 and and CC cord-286923-o4fj8kx0 145 7 Postpartum Postpartum NNP cord-286923-o4fj8kx0 145 8 Women Women NNPS cord-286923-o4fj8kx0 145 9 in in IN cord-286923-o4fj8kx0 145 10 California California NNP cord-286923-o4fj8kx0 145 11 Characteristics characteristic NNS cord-286923-o4fj8kx0 145 12 and and CC cord-286923-o4fj8kx0 145 13 outcomes outcome NNS cord-286923-o4fj8kx0 145 14 of of IN cord-286923-o4fj8kx0 145 15 pregnant pregnant JJ cord-286923-o4fj8kx0 145 16 women woman NNS cord-286923-o4fj8kx0 145 17 hospitalised hospitalise VBN cord-286923-o4fj8kx0 145 18 with with IN cord-286923-o4fj8kx0 145 19 confirmed confirm VBN cord-286923-o4fj8kx0 145 20 SARS SARS NNP cord-286923-o4fj8kx0 145 21 - - HYPH cord-286923-o4fj8kx0 145 22 CoV-2 CoV-2 NNP cord-286923-o4fj8kx0 145 23 infection infection NN cord-286923-o4fj8kx0 145 24 in in IN cord-286923-o4fj8kx0 145 25 the the DT cord-286923-o4fj8kx0 145 26 UK UK NNP cord-286923-o4fj8kx0 145 27 : : : cord-286923-o4fj8kx0 145 28 a a DT cord-286923-o4fj8kx0 145 29 national national JJ cord-286923-o4fj8kx0 145 30 cohort cohort NN cord-286923-o4fj8kx0 145 31 study study NN cord-286923-o4fj8kx0 145 32 using use VBG cord-286923-o4fj8kx0 145 33 the the DT cord-286923-o4fj8kx0 145 34 UK UK NNP cord-286923-o4fj8kx0 145 35 Obstetric Obstetric NNP cord-286923-o4fj8kx0 145 36 Surveillance Surveillance NNP cord-286923-o4fj8kx0 145 37 System System NNP cord-286923-o4fj8kx0 145 38 ( ( -LRB- cord-286923-o4fj8kx0 145 39 UKOSS UKOSS NNP cord-286923-o4fj8kx0 145 40 ) ) -RRB- cord-286923-o4fj8kx0 145 41 Maternal maternal JJ cord-286923-o4fj8kx0 145 42 and and CC cord-286923-o4fj8kx0 145 43 perinatal perinatal JJ cord-286923-o4fj8kx0 145 44 outcomes outcome NNS cord-286923-o4fj8kx0 145 45 with with IN cord-286923-o4fj8kx0 145 46 COVID-19 covid-19 CD cord-286923-o4fj8kx0 145 47 : : : cord-286923-o4fj8kx0 145 48 A a DT cord-286923-o4fj8kx0 145 49 systematic systematic JJ cord-286923-o4fj8kx0 145 50 review review NN cord-286923-o4fj8kx0 145 51 of of IN cord-286923-o4fj8kx0 145 52 108 108 CD cord-286923-o4fj8kx0 145 53 pregnancies pregnancy NNS cord-286923-o4fj8kx0 145 54 Coronavirus Coronavirus NNP cord-286923-o4fj8kx0 145 55 disease disease NN cord-286923-o4fj8kx0 145 56 2019 2019 CD cord-286923-o4fj8kx0 145 57 in in IN cord-286923-o4fj8kx0 145 58 pregnant pregnant JJ cord-286923-o4fj8kx0 145 59 women woman NNS cord-286923-o4fj8kx0 145 60 : : : cord-286923-o4fj8kx0 145 61 a a DT cord-286923-o4fj8kx0 145 62 report report NN cord-286923-o4fj8kx0 145 63 based base VBN cord-286923-o4fj8kx0 145 64 on on IN cord-286923-o4fj8kx0 145 65 116 116 CD cord-286923-o4fj8kx0 145 66 cases case NNS cord-286923-o4fj8kx0 146 1 COVID-19 covid-19 JJ cord-286923-o4fj8kx0 146 2 infection infection NN cord-286923-o4fj8kx0 146 3 among among IN cord-286923-o4fj8kx0 146 4 asymptomatic asymptomatic JJ cord-286923-o4fj8kx0 146 5 and and CC cord-286923-o4fj8kx0 146 6 symptomatic symptomatic JJ cord-286923-o4fj8kx0 146 7 pregnant pregnant JJ cord-286923-o4fj8kx0 146 8 women woman NNS cord-286923-o4fj8kx0 146 9 : : : cord-286923-o4fj8kx0 146 10 Two two CD cord-286923-o4fj8kx0 146 11 weeks week NNS cord-286923-o4fj8kx0 146 12 of of IN cord-286923-o4fj8kx0 146 13 confirmed confirm VBN cord-286923-o4fj8kx0 146 14 presentations presentation NNS cord-286923-o4fj8kx0 146 15 to to IN cord-286923-o4fj8kx0 146 16 an an DT cord-286923-o4fj8kx0 146 17 affiliated affiliated JJ cord-286923-o4fj8kx0 146 18 pair pair NN cord-286923-o4fj8kx0 146 19 of of IN cord-286923-o4fj8kx0 146 20 New New NNP cord-286923-o4fj8kx0 146 21 York York NNP cord-286923-o4fj8kx0 146 22 City City NNP cord-286923-o4fj8kx0 146 23 hospitals hospital NNS cord-286923-o4fj8kx0 146 24 Report Report NNP cord-286923-o4fj8kx0 146 25 of of IN cord-286923-o4fj8kx0 146 26 the the DT cord-286923-o4fj8kx0 146 27 WHO WHO NNP cord-286923-o4fj8kx0 146 28 - - HYPH cord-286923-o4fj8kx0 146 29 China China NNP cord-286923-o4fj8kx0 146 30 Joint Joint NNP cord-286923-o4fj8kx0 146 31 Mission Mission NNP cord-286923-o4fj8kx0 146 32 on on IN cord-286923-o4fj8kx0 146 33 Coronavirus Coronavirus NNP cord-286923-o4fj8kx0 146 34 Disease Disease NNP cord-286923-o4fj8kx0 146 35 Characteristics Characteristics NNPS cord-286923-o4fj8kx0 146 36 of of IN cord-286923-o4fj8kx0 146 37 Women Women NNPS cord-286923-o4fj8kx0 146 38 of of IN cord-286923-o4fj8kx0 146 39 Reproductive Reproductive NNP cord-286923-o4fj8kx0 146 40 Age Age NNP cord-286923-o4fj8kx0 146 41 with with IN cord-286923-o4fj8kx0 146 42 Laboratory Laboratory NNP cord-286923-o4fj8kx0 146 43 - - HYPH cord-286923-o4fj8kx0 146 44 Confirmed confirm VBN cord-286923-o4fj8kx0 146 45 SARS SARS NNP cord-286923-o4fj8kx0 146 46 - - HYPH cord-286923-o4fj8kx0 146 47 CoV-2 CoV-2 NNP cord-286923-o4fj8kx0 146 48 Infection infection NN cord-286923-o4fj8kx0 146 49 by by IN cord-286923-o4fj8kx0 146 50 Pregnancy Pregnancy NNP cord-286923-o4fj8kx0 146 51 Status Status NNP cord-286923-o4fj8kx0 146 52 -United -unite VBD cord-286923-o4fj8kx0 146 53 States States NNP cord-286923-o4fj8kx0 146 54 Coronavirus Coronavirus NNP cord-286923-o4fj8kx0 146 55 in in IN cord-286923-o4fj8kx0 146 56 pregnancy pregnancy NN cord-286923-o4fj8kx0 146 57 and and CC cord-286923-o4fj8kx0 146 58 delivery delivery NN cord-286923-o4fj8kx0 146 59 : : : cord-286923-o4fj8kx0 146 60 rapid rapid JJ cord-286923-o4fj8kx0 146 61 review review NN cord-286923-o4fj8kx0 146 62 Vaginal vaginal JJ cord-286923-o4fj8kx0 146 63 delivery delivery NN cord-286923-o4fj8kx0 146 64 in in IN cord-286923-o4fj8kx0 146 65 SARS SARS NNP cord-286923-o4fj8kx0 146 66 - - HYPH cord-286923-o4fj8kx0 146 67 CoV-2-infected cov-2-infecte VBN cord-286923-o4fj8kx0 146 68 pregnant pregnant JJ cord-286923-o4fj8kx0 146 69 women woman NNS cord-286923-o4fj8kx0 146 70 in in IN cord-286923-o4fj8kx0 146 71 Northern Northern NNP cord-286923-o4fj8kx0 146 72 Italy Italy NNP cord-286923-o4fj8kx0 146 73 : : : cord-286923-o4fj8kx0 146 74 a a DT cord-286923-o4fj8kx0 146 75 retrospective retrospective JJ cord-286923-o4fj8kx0 146 76 analysis analysis NN cord-286923-o4fj8kx0 146 77 Analysis Analysis NNP cord-286923-o4fj8kx0 146 78 of of IN cord-286923-o4fj8kx0 146 79 the the DT cord-286923-o4fj8kx0 146 80 susceptibility susceptibility NN cord-286923-o4fj8kx0 146 81 to to TO cord-286923-o4fj8kx0 146 82 COVID-19 covid-19 VB cord-286923-o4fj8kx0 146 83 in in IN cord-286923-o4fj8kx0 146 84 pregnancy pregnancy NN cord-286923-o4fj8kx0 146 85 and and CC cord-286923-o4fj8kx0 146 86 recommendations recommendation NNS cord-286923-o4fj8kx0 146 87 on on IN cord-286923-o4fj8kx0 146 88 potential potential JJ cord-286923-o4fj8kx0 146 89 drug drug NN cord-286923-o4fj8kx0 146 90 screening screening NN cord-286923-o4fj8kx0 147 1 Why why WRB cord-286923-o4fj8kx0 147 2 are be VBP cord-286923-o4fj8kx0 147 3 pregnant pregnant JJ cord-286923-o4fj8kx0 147 4 women woman NNS cord-286923-o4fj8kx0 147 5 susceptible susceptible JJ cord-286923-o4fj8kx0 147 6 to to IN cord-286923-o4fj8kx0 147 7 COVID-19 covid-19 VB cord-286923-o4fj8kx0 147 8 ? ? . cord-286923-o4fj8kx0 148 1 An an DT cord-286923-o4fj8kx0 148 2 immunological immunological JJ cord-286923-o4fj8kx0 148 3 viewpoint viewpoint NN cord-286923-o4fj8kx0 148 4 Receptors receptor NNS cord-286923-o4fj8kx0 148 5 for for IN cord-286923-o4fj8kx0 148 6 SARS SARS NNP cord-286923-o4fj8kx0 148 7 - - HYPH cord-286923-o4fj8kx0 148 8 CoV-2 CoV-2 NNP cord-286923-o4fj8kx0 148 9 Present Present NNP cord-286923-o4fj8kx0 148 10 in in IN cord-286923-o4fj8kx0 148 11 Wide wide JJ cord-286923-o4fj8kx0 148 12 Variety Variety NNP cord-286923-o4fj8kx0 148 13 of of IN cord-286923-o4fj8kx0 148 14 Human Human NNP cord-286923-o4fj8kx0 148 15 Cells cell NNS cord-286923-o4fj8kx0 149 1 Clinical clinical JJ cord-286923-o4fj8kx0 149 2 course course NN cord-286923-o4fj8kx0 149 3 and and CC cord-286923-o4fj8kx0 149 4 risk risk NN cord-286923-o4fj8kx0 149 5 factors factor NNS cord-286923-o4fj8kx0 149 6 for for IN cord-286923-o4fj8kx0 149 7 mortality mortality NN cord-286923-o4fj8kx0 149 8 of of IN cord-286923-o4fj8kx0 149 9 adult adult NN cord-286923-o4fj8kx0 149 10 inpatients inpatient NNS cord-286923-o4fj8kx0 149 11 with with IN cord-286923-o4fj8kx0 149 12 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 149 13 in in IN cord-286923-o4fj8kx0 149 14 Wuhan Wuhan NNP cord-286923-o4fj8kx0 149 15 , , , cord-286923-o4fj8kx0 149 16 China China NNP cord-286923-o4fj8kx0 149 17 : : : cord-286923-o4fj8kx0 150 1 a a DT cord-286923-o4fj8kx0 150 2 retrospective retrospective JJ cord-286923-o4fj8kx0 150 3 cohort cohort NN cord-286923-o4fj8kx0 150 4 study study NN cord-286923-o4fj8kx0 150 5 Pulmonary pulmonary JJ cord-286923-o4fj8kx0 150 6 intravascular intravascular JJ cord-286923-o4fj8kx0 150 7 coagulation coagulation NN cord-286923-o4fj8kx0 150 8 in in IN cord-286923-o4fj8kx0 150 9 COVID-19 covid-19 NN cord-286923-o4fj8kx0 150 10 : : : cord-286923-o4fj8kx0 150 11 possible possible JJ cord-286923-o4fj8kx0 150 12 pathogenesis pathogenesis NN cord-286923-o4fj8kx0 150 13 and and CC cord-286923-o4fj8kx0 150 14 recommendations recommendation NNS cord-286923-o4fj8kx0 150 15 on on IN cord-286923-o4fj8kx0 150 16 anticoagulant anticoagulant JJ cord-286923-o4fj8kx0 150 17 / / SYM cord-286923-o4fj8kx0 150 18 thrombolytic thrombolytic NN cord-286923-o4fj8kx0 150 19 therapy therapy NN cord-286923-o4fj8kx0 150 20 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 150 21 : : : cord-286923-o4fj8kx0 150 22 towards towards IN cord-286923-o4fj8kx0 150 23 understanding understanding NN cord-286923-o4fj8kx0 150 24 of of IN cord-286923-o4fj8kx0 150 25 pathogenesis pathogenesis NN cord-286923-o4fj8kx0 150 26 Thromboembolic Thromboembolic NNP cord-286923-o4fj8kx0 150 27 risk risk NN cord-286923-o4fj8kx0 150 28 and and CC cord-286923-o4fj8kx0 150 29 anticoagulant anticoagulant NN cord-286923-o4fj8kx0 150 30 therapy therapy NN cord-286923-o4fj8kx0 150 31 in in IN cord-286923-o4fj8kx0 150 32 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 150 33 patients patient NNS cord-286923-o4fj8kx0 150 34 : : : cord-286923-o4fj8kx0 150 35 emerging emerge VBG cord-286923-o4fj8kx0 150 36 evidence evidence NN cord-286923-o4fj8kx0 150 37 and and CC cord-286923-o4fj8kx0 150 38 call call VB cord-286923-o4fj8kx0 150 39 for for IN cord-286923-o4fj8kx0 150 40 action action NN cord-286923-o4fj8kx0 150 41 Tissue Tissue NNP cord-286923-o4fj8kx0 150 42 Plasminogen Plasminogen NNP cord-286923-o4fj8kx0 150 43 Activator Activator NNP cord-286923-o4fj8kx0 150 44 ( ( -LRB- cord-286923-o4fj8kx0 150 45 tPA tPA NNP cord-286923-o4fj8kx0 150 46 ) ) -RRB- cord-286923-o4fj8kx0 150 47 Treatment Treatment NNP cord-286923-o4fj8kx0 150 48 for for IN cord-286923-o4fj8kx0 150 49 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 150 50 Associated Associated NNP cord-286923-o4fj8kx0 150 51 Acute Acute NNP cord-286923-o4fj8kx0 150 52 Respiratory Respiratory NNP cord-286923-o4fj8kx0 150 53 Distress Distress NNP cord-286923-o4fj8kx0 150 54 Syndrome Syndrome NNP cord-286923-o4fj8kx0 150 55 ( ( -LRB- cord-286923-o4fj8kx0 150 56 ARDS ARDS NNP cord-286923-o4fj8kx0 150 57 ) ) -RRB- cord-286923-o4fj8kx0 150 58 : : : cord-286923-o4fj8kx0 151 1 A a DT cord-286923-o4fj8kx0 151 2 Case Case NNP cord-286923-o4fj8kx0 151 3 Series Series NNP cord-286923-o4fj8kx0 151 4 Coagulation Coagulation NNP cord-286923-o4fj8kx0 151 5 abnormalities abnormality NNS cord-286923-o4fj8kx0 151 6 and and CC cord-286923-o4fj8kx0 151 7 thrombosis thrombosis NN cord-286923-o4fj8kx0 151 8 in in IN cord-286923-o4fj8kx0 151 9 patients patient NNS cord-286923-o4fj8kx0 151 10 with with IN cord-286923-o4fj8kx0 151 11 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 151 12 Pathological pathological JJ cord-286923-o4fj8kx0 151 13 findings finding NNS cord-286923-o4fj8kx0 151 14 of of IN cord-286923-o4fj8kx0 151 15 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 151 16 associated associate VBN cord-286923-o4fj8kx0 151 17 with with IN cord-286923-o4fj8kx0 151 18 acute acute JJ cord-286923-o4fj8kx0 151 19 respiratory respiratory JJ cord-286923-o4fj8kx0 151 20 distress distress NN cord-286923-o4fj8kx0 151 21 syndrome syndrome NN cord-286923-o4fj8kx0 151 22 Lung lung NN cord-286923-o4fj8kx0 151 23 transplantation transplantation NN cord-286923-o4fj8kx0 151 24 as as IN cord-286923-o4fj8kx0 151 25 therapeutic therapeutic JJ cord-286923-o4fj8kx0 151 26 option option NN cord-286923-o4fj8kx0 151 27 in in IN cord-286923-o4fj8kx0 151 28 acute acute JJ cord-286923-o4fj8kx0 151 29 respiratory respiratory JJ cord-286923-o4fj8kx0 151 30 distress distress NN cord-286923-o4fj8kx0 151 31 syndrome syndrome NN cord-286923-o4fj8kx0 151 32 for for IN cord-286923-o4fj8kx0 151 33 COVID-19-related covid-19-related JJ cord-286923-o4fj8kx0 151 34 pulmonary pulmonary JJ cord-286923-o4fj8kx0 151 35 fibrosis fibrosis NN cord-286923-o4fj8kx0 152 1 Molecular molecular JJ cord-286923-o4fj8kx0 152 2 immune immune JJ cord-286923-o4fj8kx0 152 3 pathogenesis pathogenesis NN cord-286923-o4fj8kx0 152 4 and and CC cord-286923-o4fj8kx0 152 5 diagnosis diagnosis NN cord-286923-o4fj8kx0 152 6 of of IN cord-286923-o4fj8kx0 152 7 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 152 8 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 152 9 : : : cord-286923-o4fj8kx0 152 10 Pathogenesis Pathogenesis NNP cord-286923-o4fj8kx0 152 11 , , , cord-286923-o4fj8kx0 152 12 cytokine cytokine JJ cord-286923-o4fj8kx0 152 13 storm storm NN cord-286923-o4fj8kx0 152 14 and and CC cord-286923-o4fj8kx0 152 15 therapeutic therapeutic JJ cord-286923-o4fj8kx0 152 16 potential potential NN cord-286923-o4fj8kx0 152 17 of of IN cord-286923-o4fj8kx0 152 18 interferons interferon NNS cord-286923-o4fj8kx0 152 19 Inflammatory inflammatory JJ cord-286923-o4fj8kx0 152 20 and and CC cord-286923-o4fj8kx0 152 21 anti anti JJ cord-286923-o4fj8kx0 152 22 - - JJ cord-286923-o4fj8kx0 152 23 inflammatory inflammatory JJ cord-286923-o4fj8kx0 152 24 markers marker NNS cord-286923-o4fj8kx0 152 25 in in IN cord-286923-o4fj8kx0 152 26 plasma plasma NN cord-286923-o4fj8kx0 152 27 : : : cord-286923-o4fj8kx0 152 28 from from IN cord-286923-o4fj8kx0 152 29 late late JJ cord-286923-o4fj8kx0 152 30 pregnancy pregnancy NN cord-286923-o4fj8kx0 152 31 to to IN cord-286923-o4fj8kx0 153 1 early early JJ cord-286923-o4fj8kx0 153 2 postpartum postpartum NN cord-286923-o4fj8kx0 153 3 Human human JJ cord-286923-o4fj8kx0 153 4 chorionic chorionic JJ cord-286923-o4fj8kx0 153 5 gonadotropin gonadotropin NN cord-286923-o4fj8kx0 153 6 attracts attract VBZ cord-286923-o4fj8kx0 153 7 regulatory regulatory JJ cord-286923-o4fj8kx0 153 8 T t NN cord-286923-o4fj8kx0 153 9 cells cell NNS cord-286923-o4fj8kx0 153 10 into into IN cord-286923-o4fj8kx0 153 11 the the DT cord-286923-o4fj8kx0 153 12 fetal fetal JJ cord-286923-o4fj8kx0 153 13 - - HYPH cord-286923-o4fj8kx0 153 14 maternal maternal JJ cord-286923-o4fj8kx0 153 15 interface interface NN cord-286923-o4fj8kx0 153 16 during during IN cord-286923-o4fj8kx0 153 17 early early JJ cord-286923-o4fj8kx0 153 18 human human JJ cord-286923-o4fj8kx0 153 19 pregnancy pregnancy NN cord-286923-o4fj8kx0 153 20 Macrophage macrophage NN cord-286923-o4fj8kx0 153 21 plasticity plasticity NN cord-286923-o4fj8kx0 153 22 and and CC cord-286923-o4fj8kx0 153 23 polarization polarization NN cord-286923-o4fj8kx0 153 24 in in IN cord-286923-o4fj8kx0 153 25 tissue tissue NN cord-286923-o4fj8kx0 153 26 repair repair NN cord-286923-o4fj8kx0 153 27 and and CC cord-286923-o4fj8kx0 153 28 remodeling remodel VBG cord-286923-o4fj8kx0 153 29 Clinical clinical JJ cord-286923-o4fj8kx0 153 30 features feature NNS cord-286923-o4fj8kx0 153 31 of of IN cord-286923-o4fj8kx0 153 32 patients patient NNS cord-286923-o4fj8kx0 153 33 infected infect VBN cord-286923-o4fj8kx0 153 34 with with IN cord-286923-o4fj8kx0 153 35 2019 2019 CD cord-286923-o4fj8kx0 153 36 novel novel JJ cord-286923-o4fj8kx0 153 37 coronavirus coronavirus NN cord-286923-o4fj8kx0 153 38 in in IN cord-286923-o4fj8kx0 153 39 Wuhan Wuhan NNP cord-286923-o4fj8kx0 153 40 Coronavirus Coronavirus NNP cord-286923-o4fj8kx0 153 41 disease disease NN cord-286923-o4fj8kx0 153 42 2019 2019 CD cord-286923-o4fj8kx0 153 43 ( ( -LRB- cord-286923-o4fj8kx0 153 44 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 153 45 ) ) -RRB- cord-286923-o4fj8kx0 153 46 pandemic pandemic NN cord-286923-o4fj8kx0 153 47 and and CC cord-286923-o4fj8kx0 153 48 pregnancy pregnancy NN cord-286923-o4fj8kx0 153 49 Plasma plasma NN cord-286923-o4fj8kx0 153 50 inflammatory inflammatory JJ cord-286923-o4fj8kx0 153 51 cytokines cytokine NNS cord-286923-o4fj8kx0 153 52 and and CC cord-286923-o4fj8kx0 153 53 chemokines chemokine NNS cord-286923-o4fj8kx0 153 54 in in IN cord-286923-o4fj8kx0 153 55 severe severe JJ cord-286923-o4fj8kx0 153 56 acute acute JJ cord-286923-o4fj8kx0 153 57 respiratory respiratory JJ cord-286923-o4fj8kx0 153 58 syndrome syndrome NN cord-286923-o4fj8kx0 153 59 ( ( -LRB- cord-286923-o4fj8kx0 154 1 SARS SARS NNP cord-286923-o4fj8kx0 154 2 ) ) -RRB- cord-286923-o4fj8kx0 154 3 MERS MERS NNP cord-286923-o4fj8kx0 154 4 - - HYPH cord-286923-o4fj8kx0 154 5 CoV cov NN cord-286923-o4fj8kx0 154 6 infection infection NN cord-286923-o4fj8kx0 154 7 in in IN cord-286923-o4fj8kx0 154 8 humans human NNS cord-286923-o4fj8kx0 154 9 is be VBZ cord-286923-o4fj8kx0 154 10 associated associate VBN cord-286923-o4fj8kx0 154 11 with with IN cord-286923-o4fj8kx0 154 12 a a DT cord-286923-o4fj8kx0 154 13 pro pro JJ cord-286923-o4fj8kx0 154 14 - - JJ cord-286923-o4fj8kx0 154 15 inflammatory inflammatory JJ cord-286923-o4fj8kx0 154 16 Th1 th1 NN cord-286923-o4fj8kx0 154 17 and and CC cord-286923-o4fj8kx0 154 18 Th17 Th17 NNP cord-286923-o4fj8kx0 154 19 cytokine cytokine NN cord-286923-o4fj8kx0 154 20 profile profile JJ cord-286923-o4fj8kx0 154 21 Cytokine cytokine NN cord-286923-o4fj8kx0 154 22 - - HYPH cord-286923-o4fj8kx0 154 23 Targeted target VBN cord-286923-o4fj8kx0 154 24 Therapy Therapy NNP cord-286923-o4fj8kx0 154 25 in in IN cord-286923-o4fj8kx0 154 26 Severely severely RB cord-286923-o4fj8kx0 154 27 ill ill JJ cord-286923-o4fj8kx0 154 28 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 154 29 Patients patient NNS cord-286923-o4fj8kx0 154 30 : : : cord-286923-o4fj8kx0 154 31 Options option NNS cord-286923-o4fj8kx0 154 32 and and CC cord-286923-o4fj8kx0 154 33 Cautions Cautions NNPS cord-286923-o4fj8kx0 154 34 IL-6 IL-6 NNP cord-286923-o4fj8kx0 154 35 as as IN cord-286923-o4fj8kx0 154 36 a a DT cord-286923-o4fj8kx0 154 37 keystone keystone JJ cord-286923-o4fj8kx0 154 38 cytokine cytokine NN cord-286923-o4fj8kx0 154 39 in in IN cord-286923-o4fj8kx0 154 40 health health NN cord-286923-o4fj8kx0 154 41 and and CC cord-286923-o4fj8kx0 154 42 disease disease NN cord-286923-o4fj8kx0 154 43 Immunotherapeutic immunotherapeutic JJ cord-286923-o4fj8kx0 154 44 implications implication NNS cord-286923-o4fj8kx0 154 45 of of IN cord-286923-o4fj8kx0 154 46 IL-6 IL-6 NNP cord-286923-o4fj8kx0 154 47 blockade blockade NN cord-286923-o4fj8kx0 154 48 for for IN cord-286923-o4fj8kx0 154 49 cytokine cytokine NN cord-286923-o4fj8kx0 154 50 storm storm NN cord-286923-o4fj8kx0 155 1 Interleukin-10 Interleukin-10 NNP cord-286923-o4fj8kx0 155 2 : : : cord-286923-o4fj8kx0 156 1 A a DT cord-286923-o4fj8kx0 156 2 Multi multi JJ cord-286923-o4fj8kx0 156 3 - - JJ cord-286923-o4fj8kx0 156 4 Faceted faceted JJ cord-286923-o4fj8kx0 156 5 Agent Agent NNP cord-286923-o4fj8kx0 156 6 of of IN cord-286923-o4fj8kx0 156 7 Pregnancy Pregnancy NNP cord-286923-o4fj8kx0 157 1 The the DT cord-286923-o4fj8kx0 157 2 Role role NN cord-286923-o4fj8kx0 157 3 of of IN cord-286923-o4fj8kx0 157 4 the the DT cord-286923-o4fj8kx0 157 5 Anti anti JJ cord-286923-o4fj8kx0 157 6 - - JJ cord-286923-o4fj8kx0 157 7 Inflammatory inflammatory JJ cord-286923-o4fj8kx0 157 8 Cytokine cytokine NN cord-286923-o4fj8kx0 157 9 Interleukin-10 interleukin-10 NN cord-286923-o4fj8kx0 157 10 in in IN cord-286923-o4fj8kx0 157 11 Tissue Tissue NNP cord-286923-o4fj8kx0 157 12 Fibrosis Fibrosis NNP cord-286923-o4fj8kx0 157 13 Primary Primary NNP cord-286923-o4fj8kx0 157 14 effect effect NN cord-286923-o4fj8kx0 157 15 of of IN cord-286923-o4fj8kx0 157 16 1α,25(OH)₂D₃ 1α,25(oh)₂d₃ CD cord-286923-o4fj8kx0 157 17 on on IN cord-286923-o4fj8kx0 157 18 IL-10 IL-10 NNP cord-286923-o4fj8kx0 157 19 expression expression NN cord-286923-o4fj8kx0 157 20 in in IN cord-286923-o4fj8kx0 157 21 monocytes monocyte NNS cord-286923-o4fj8kx0 157 22 is be VBZ cord-286923-o4fj8kx0 157 23 short short JJ cord-286923-o4fj8kx0 157 24 - - HYPH cord-286923-o4fj8kx0 157 25 term term NN cord-286923-o4fj8kx0 157 26 down down IN cord-286923-o4fj8kx0 157 27 - - HYPH cord-286923-o4fj8kx0 157 28 regulation regulation NN cord-286923-o4fj8kx0 157 29 Deficiency deficiency NN cord-286923-o4fj8kx0 157 30 of of IN cord-286923-o4fj8kx0 157 31 decidual decidual NN cord-286923-o4fj8kx0 157 32 IL-10 IL-10 NNP cord-286923-o4fj8kx0 157 33 in in IN cord-286923-o4fj8kx0 157 34 first first JJ cord-286923-o4fj8kx0 157 35 trimester trimester NN cord-286923-o4fj8kx0 157 36 missed miss VBN cord-286923-o4fj8kx0 157 37 abortion abortion NN cord-286923-o4fj8kx0 157 38 : : : cord-286923-o4fj8kx0 157 39 a a DT cord-286923-o4fj8kx0 157 40 lack lack NN cord-286923-o4fj8kx0 157 41 of of IN cord-286923-o4fj8kx0 157 42 correlation correlation NN cord-286923-o4fj8kx0 157 43 with with IN cord-286923-o4fj8kx0 157 44 the the DT cord-286923-o4fj8kx0 157 45 decidual decidual JJ cord-286923-o4fj8kx0 157 46 immune immune JJ cord-286923-o4fj8kx0 157 47 cell cell NN cord-286923-o4fj8kx0 157 48 profile profile NN cord-286923-o4fj8kx0 158 1 Interleukin-10 Interleukin-10 NNP cord-286923-o4fj8kx0 158 2 2849AA 2849aa CD cord-286923-o4fj8kx0 158 3 genotype genotype NN cord-286923-o4fj8kx0 158 4 protects protect VBZ cord-286923-o4fj8kx0 158 5 against against IN cord-286923-o4fj8kx0 158 6 pre pre JJ cord-286923-o4fj8kx0 158 7 - - JJ cord-286923-o4fj8kx0 158 8 eclampsia eclampsia JJ cord-286923-o4fj8kx0 158 9 Novel novel JJ cord-286923-o4fj8kx0 158 10 approaches approach NNS cord-286923-o4fj8kx0 158 11 for for IN cord-286923-o4fj8kx0 158 12 mechanistic mechanistic JJ cord-286923-o4fj8kx0 158 13 understanding understanding NN cord-286923-o4fj8kx0 158 14 and and CC cord-286923-o4fj8kx0 158 15 predicting predict VBG cord-286923-o4fj8kx0 158 16 preeclampsia preeclampsia JJ cord-286923-o4fj8kx0 158 17 Abnormal abnormal JJ cord-286923-o4fj8kx0 158 18 coagulation coagulation NN cord-286923-o4fj8kx0 158 19 parameters parameter NNS cord-286923-o4fj8kx0 158 20 are be VBP cord-286923-o4fj8kx0 158 21 associated associate VBN cord-286923-o4fj8kx0 158 22 with with IN cord-286923-o4fj8kx0 158 23 poor poor JJ cord-286923-o4fj8kx0 158 24 prognosis prognosis NN cord-286923-o4fj8kx0 158 25 in in IN cord-286923-o4fj8kx0 158 26 patients patient NNS cord-286923-o4fj8kx0 158 27 with with IN cord-286923-o4fj8kx0 158 28 novel novel JJ cord-286923-o4fj8kx0 158 29 coronavirus coronavirus NN cord-286923-o4fj8kx0 158 30 pneumonia pneumonia NN cord-286923-o4fj8kx0 158 31 Proteinase Proteinase NNP cord-286923-o4fj8kx0 158 32 activated activate VBD cord-286923-o4fj8kx0 158 33 receptors receptor NNS cord-286923-o4fj8kx0 158 34 in in IN cord-286923-o4fj8kx0 158 35 fibroproliferative fibroproliferative JJ cord-286923-o4fj8kx0 158 36 lung lung NN cord-286923-o4fj8kx0 158 37 disease disease NN cord-286923-o4fj8kx0 158 38 Activation Activation NNP cord-286923-o4fj8kx0 158 39 of of IN cord-286923-o4fj8kx0 158 40 protease protease NN cord-286923-o4fj8kx0 158 41 - - HYPH cord-286923-o4fj8kx0 158 42 activated activate VBN cord-286923-o4fj8kx0 158 43 receptor receptor NN cord-286923-o4fj8kx0 158 44 ( ( -LRB- cord-286923-o4fj8kx0 158 45 PAR)-1 par)-1 NN cord-286923-o4fj8kx0 158 46 , , , cord-286923-o4fj8kx0 158 47 PAR-2 PAR-2 NNP cord-286923-o4fj8kx0 158 48 , , , cord-286923-o4fj8kx0 158 49 and and CC cord-286923-o4fj8kx0 158 50 PAR-4 PAR-4 NNP cord-286923-o4fj8kx0 158 51 stimulates stimulate VBZ cord-286923-o4fj8kx0 158 52 IL-6 IL-6 NNP cord-286923-o4fj8kx0 158 53 , , , cord-286923-o4fj8kx0 158 54 IL-8 IL-8 NNP cord-286923-o4fj8kx0 158 55 , , , cord-286923-o4fj8kx0 158 56 and and CC cord-286923-o4fj8kx0 158 57 prostaglandin prostaglandin NN cord-286923-o4fj8kx0 158 58 E2 E2 NNP cord-286923-o4fj8kx0 158 59 release release NN cord-286923-o4fj8kx0 158 60 from from IN cord-286923-o4fj8kx0 158 61 human human JJ cord-286923-o4fj8kx0 158 62 respiratory respiratory JJ cord-286923-o4fj8kx0 158 63 epithelial epithelial JJ cord-286923-o4fj8kx0 158 64 cells cell NNS cord-286923-o4fj8kx0 158 65 Activation activation NN cord-286923-o4fj8kx0 158 66 of of IN cord-286923-o4fj8kx0 158 67 mast mast NN cord-286923-o4fj8kx0 158 68 cells cell NNS cord-286923-o4fj8kx0 158 69 induced induce VBN cord-286923-o4fj8kx0 158 70 by by IN cord-286923-o4fj8kx0 158 71 agonists agonist NNS cord-286923-o4fj8kx0 158 72 of of IN cord-286923-o4fj8kx0 158 73 proteinase proteinase NN cord-286923-o4fj8kx0 158 74 - - HYPH cord-286923-o4fj8kx0 158 75 activated activate VBN cord-286923-o4fj8kx0 158 76 receptors receptor NNS cord-286923-o4fj8kx0 158 77 under under IN cord-286923-o4fj8kx0 158 78 normal normal JJ cord-286923-o4fj8kx0 158 79 conditions condition NNS cord-286923-o4fj8kx0 158 80 and and CC cord-286923-o4fj8kx0 158 81 during during IN cord-286923-o4fj8kx0 158 82 acute acute JJ cord-286923-o4fj8kx0 158 83 inflammation inflammation NN cord-286923-o4fj8kx0 158 84 in in IN cord-286923-o4fj8kx0 158 85 rats rat NNS cord-286923-o4fj8kx0 158 86 Receptors receptor NNS cord-286923-o4fj8kx0 158 87 of of IN cord-286923-o4fj8kx0 158 88 the the DT cord-286923-o4fj8kx0 158 89 PAR PAR NNP cord-286923-o4fj8kx0 158 90 family family NN cord-286923-o4fj8kx0 158 91 as as IN cord-286923-o4fj8kx0 158 92 a a DT cord-286923-o4fj8kx0 158 93 link link NN cord-286923-o4fj8kx0 158 94 between between IN cord-286923-o4fj8kx0 158 95 blood blood NN cord-286923-o4fj8kx0 158 96 coagulation coagulation NN cord-286923-o4fj8kx0 158 97 and and CC cord-286923-o4fj8kx0 158 98 inflammation inflammation NN cord-286923-o4fj8kx0 159 1 The the DT cord-286923-o4fj8kx0 159 2 pattern pattern NN cord-286923-o4fj8kx0 159 3 of of IN cord-286923-o4fj8kx0 159 4 expression expression NN cord-286923-o4fj8kx0 159 5 of of IN cord-286923-o4fj8kx0 159 6 proteas protea NNS cord-286923-o4fj8kx0 159 7 - - HYPH cord-286923-o4fj8kx0 159 8 activated activate VBN cord-286923-o4fj8kx0 159 9 receptors receptor NNS cord-286923-o4fj8kx0 159 10 ( ( -LRB- cord-286923-o4fj8kx0 159 11 PARs PARs NNP cord-286923-o4fj8kx0 159 12 ) ) -RRB- cord-286923-o4fj8kx0 159 13 during during IN cord-286923-o4fj8kx0 159 14 early early JJ cord-286923-o4fj8kx0 159 15 trophoblastic trophoblastic JJ cord-286923-o4fj8kx0 159 16 development development NN cord-286923-o4fj8kx0 159 17 Haemostatic Haemostatic NNP cord-286923-o4fj8kx0 159 18 changes change NNS cord-286923-o4fj8kx0 159 19 in in IN cord-286923-o4fj8kx0 159 20 pregnancy pregnancy NN cord-286923-o4fj8kx0 159 21 Role role NN cord-286923-o4fj8kx0 159 22 of of IN cord-286923-o4fj8kx0 159 23 hormone hormone NN cord-286923-o4fj8kx0 159 24 - - HYPH cord-286923-o4fj8kx0 159 25 controlled control VBN cord-286923-o4fj8kx0 159 26 Th1-and th1-and NN cord-286923-o4fj8kx0 159 27 Th2-type Th2-type NNP cord-286923-o4fj8kx0 159 28 cytokines cytokine NNS cord-286923-o4fj8kx0 159 29 in in IN cord-286923-o4fj8kx0 159 30 successful successful JJ cord-286923-o4fj8kx0 159 31 pregnancy pregnancy NN cord-286923-o4fj8kx0 160 1 Progesterone progesterone NN cord-286923-o4fj8kx0 160 2 favors favor VBZ cord-286923-o4fj8kx0 160 3 the the DT cord-286923-o4fj8kx0 160 4 development development NN cord-286923-o4fj8kx0 160 5 of of IN cord-286923-o4fj8kx0 160 6 human human JJ cord-286923-o4fj8kx0 160 7 T T NNP cord-286923-o4fj8kx0 160 8 helper helper NN cord-286923-o4fj8kx0 160 9 cells cell NNS cord-286923-o4fj8kx0 160 10 producing produce VBG cord-286923-o4fj8kx0 160 11 Th2-type Th2-type NNP cord-286923-o4fj8kx0 160 12 cytokines cytokine NNS cord-286923-o4fj8kx0 160 13 and and CC cord-286923-o4fj8kx0 160 14 promotes promote VBZ cord-286923-o4fj8kx0 160 15 both both CC cord-286923-o4fj8kx0 160 16 IL-4 IL-4 NNP cord-286923-o4fj8kx0 160 17 production production NN cord-286923-o4fj8kx0 160 18 and and CC cord-286923-o4fj8kx0 160 19 membrane membrane NN cord-286923-o4fj8kx0 160 20 CD30 CD30 NNP cord-286923-o4fj8kx0 160 21 expression expression NN cord-286923-o4fj8kx0 160 22 in in IN cord-286923-o4fj8kx0 160 23 established establish VBN cord-286923-o4fj8kx0 160 24 Th1 th1 CD cord-286923-o4fj8kx0 160 25 cell cell NN cord-286923-o4fj8kx0 160 26 clones clone NNS cord-286923-o4fj8kx0 161 1 The the DT cord-286923-o4fj8kx0 161 2 immunological immunological JJ cord-286923-o4fj8kx0 161 3 pregnancy pregnancy NN cord-286923-o4fj8kx0 161 4 protective protective JJ cord-286923-o4fj8kx0 161 5 effect effect NN cord-286923-o4fj8kx0 161 6 of of IN cord-286923-o4fj8kx0 161 7 progesterone progesterone NN cord-286923-o4fj8kx0 161 8 is be VBZ cord-286923-o4fj8kx0 161 9 manifested manifest VBN cord-286923-o4fj8kx0 161 10 via via IN cord-286923-o4fj8kx0 161 11 controlling control VBG cord-286923-o4fj8kx0 161 12 cytokine cytokine NN cord-286923-o4fj8kx0 161 13 production production NN cord-286923-o4fj8kx0 161 14 Toll Toll NNP cord-286923-o4fj8kx0 161 15 - - HYPH cord-286923-o4fj8kx0 161 16 like like JJ cord-286923-o4fj8kx0 161 17 receptor-4-mediated receptor-4-mediated NNP cord-286923-o4fj8kx0 161 18 macrophage macrophage NN cord-286923-o4fj8kx0 161 19 activation activation NN cord-286923-o4fj8kx0 161 20 is be VBZ cord-286923-o4fj8kx0 161 21 differentially differentially RB cord-286923-o4fj8kx0 161 22 regulated regulate VBN cord-286923-o4fj8kx0 161 23 by by IN cord-286923-o4fj8kx0 161 24 progesterone progesterone NN cord-286923-o4fj8kx0 161 25 via via IN cord-286923-o4fj8kx0 161 26 the the DT cord-286923-o4fj8kx0 161 27 glucocorticoid glucocorticoid NN cord-286923-o4fj8kx0 161 28 and and CC cord-286923-o4fj8kx0 161 29 progesterone progesterone NN cord-286923-o4fj8kx0 161 30 receptors receptor NNS cord-286923-o4fj8kx0 161 31 Progesterone Progesterone NNP cord-286923-o4fj8kx0 161 32 treatment treatment NN cord-286923-o4fj8kx0 161 33 reduces reduce VBZ cord-286923-o4fj8kx0 161 34 disease disease NN cord-286923-o4fj8kx0 161 35 severity severity NN cord-286923-o4fj8kx0 161 36 and and CC cord-286923-o4fj8kx0 161 37 increases increase NNS cord-286923-o4fj8kx0 162 1 IL-10 IL-10 NNP cord-286923-o4fj8kx0 162 2 in in IN cord-286923-o4fj8kx0 162 3 experimental experimental JJ cord-286923-o4fj8kx0 162 4 autoimmune autoimmune JJ cord-286923-o4fj8kx0 162 5 encephalomyelitis encephalomyelitis NN cord-286923-o4fj8kx0 162 6 Multiple multiple JJ cord-286923-o4fj8kx0 162 7 sclerosis sclerosis NN cord-286923-o4fj8kx0 162 8 3 3 CD cord-286923-o4fj8kx0 162 9 ; ; : cord-286923-o4fj8kx0 163 1 Gender gender NN cord-286923-o4fj8kx0 163 2 and and CC cord-286923-o4fj8kx0 163 3 multiple multiple JJ cord-286923-o4fj8kx0 163 4 sclerosis sclerosis NN cord-286923-o4fj8kx0 163 5 154 154 CD cord-286923-o4fj8kx0 163 6 - - SYM cord-286923-o4fj8kx0 163 7 189 189 CD cord-286923-o4fj8kx0 163 8 Immune immune JJ cord-286923-o4fj8kx0 163 9 modulation modulation NN cord-286923-o4fj8kx0 163 10 in in IN cord-286923-o4fj8kx0 163 11 multiple multiple JJ cord-286923-o4fj8kx0 163 12 sclerosis sclerosis NN cord-286923-o4fj8kx0 163 13 patients patient NNS cord-286923-o4fj8kx0 163 14 treated treat VBN cord-286923-o4fj8kx0 163 15 with with IN cord-286923-o4fj8kx0 163 16 the the DT cord-286923-o4fj8kx0 163 17 pregnancy pregnancy NN cord-286923-o4fj8kx0 163 18 hormone hormone NN cord-286923-o4fj8kx0 164 1 estriol estriol NNP cord-286923-o4fj8kx0 165 1 The the DT cord-286923-o4fj8kx0 165 2 complex complex JJ cord-286923-o4fj8kx0 165 3 role role NN cord-286923-o4fj8kx0 165 4 of of IN cord-286923-o4fj8kx0 165 5 estrogens estrogen NNS cord-286923-o4fj8kx0 165 6 in in IN cord-286923-o4fj8kx0 165 7 inflammation inflammation NN cord-286923-o4fj8kx0 166 1 Sex sex NN cord-286923-o4fj8kx0 166 2 hormones hormone NNS cord-286923-o4fj8kx0 166 3 and and CC cord-286923-o4fj8kx0 166 4 the the DT cord-286923-o4fj8kx0 166 5 immune immune JJ cord-286923-o4fj8kx0 166 6 response response NN cord-286923-o4fj8kx0 166 7 in in IN cord-286923-o4fj8kx0 166 8 humans human NNS cord-286923-o4fj8kx0 166 9 Differential differential JJ cord-286923-o4fj8kx0 166 10 neuroprotective neuroprotective JJ cord-286923-o4fj8kx0 166 11 and and CC cord-286923-o4fj8kx0 166 12 anti anti JJ cord-286923-o4fj8kx0 166 13 - - JJ cord-286923-o4fj8kx0 166 14 inflammatory inflammatory JJ cord-286923-o4fj8kx0 166 15 effects effect NNS cord-286923-o4fj8kx0 166 16 of of IN cord-286923-o4fj8kx0 166 17 estrogen estrogen NN cord-286923-o4fj8kx0 166 18 receptor receptor NN cord-286923-o4fj8kx0 166 19 ( ( -LRB- cord-286923-o4fj8kx0 166 20 ER ER NNP cord-286923-o4fj8kx0 166 21 ) ) -RRB- cord-286923-o4fj8kx0 166 22 alpha alpha NN cord-286923-o4fj8kx0 166 23 and and CC cord-286923-o4fj8kx0 166 24 ERbeta erbeta JJ cord-286923-o4fj8kx0 166 25 ligand ligand NN cord-286923-o4fj8kx0 166 26 treatment treatment NN cord-286923-o4fj8kx0 166 27 Estriol Estriol NNP cord-286923-o4fj8kx0 166 28 treatment treatment NN cord-286923-o4fj8kx0 166 29 ameliorates ameliorate VBZ cord-286923-o4fj8kx0 166 30 disease disease NN cord-286923-o4fj8kx0 166 31 in in IN cord-286923-o4fj8kx0 166 32 males male NNS cord-286923-o4fj8kx0 166 33 with with IN cord-286923-o4fj8kx0 166 34 experimental experimental JJ cord-286923-o4fj8kx0 166 35 autoimmune autoimmune JJ cord-286923-o4fj8kx0 166 36 encephalomyelitis encephalomyelitis NN cord-286923-o4fj8kx0 166 37 : : : cord-286923-o4fj8kx0 166 38 implications implication NNS cord-286923-o4fj8kx0 166 39 for for IN cord-286923-o4fj8kx0 166 40 multiple multiple JJ cord-286923-o4fj8kx0 166 41 sclerosis sclerosis NN cord-286923-o4fj8kx0 167 1 Estriol Estriol NNP cord-286923-o4fj8kx0 167 2 ameliorates ameliorate VBZ cord-286923-o4fj8kx0 167 3 autoimmune autoimmune JJ cord-286923-o4fj8kx0 167 4 demyelinating demyelinate VBG cord-286923-o4fj8kx0 167 5 disease disease NN cord-286923-o4fj8kx0 167 6 : : : cord-286923-o4fj8kx0 167 7 implications implication NNS cord-286923-o4fj8kx0 167 8 for for IN cord-286923-o4fj8kx0 167 9 multiple multiple JJ cord-286923-o4fj8kx0 167 10 sclerosis sclerosis NN cord-286923-o4fj8kx0 168 1 Estriol Estriol NNP cord-286923-o4fj8kx0 168 2 Reduces reduce VBZ cord-286923-o4fj8kx0 168 3 Pulmonary Pulmonary NNP cord-286923-o4fj8kx0 168 4 Immune Immune NNP cord-286923-o4fj8kx0 168 5 Cell Cell NNP cord-286923-o4fj8kx0 168 6 Recruitment Recruitment NNP cord-286923-o4fj8kx0 168 7 and and CC cord-286923-o4fj8kx0 168 8 Inflammation inflammation NN cord-286923-o4fj8kx0 168 9 to to TO cord-286923-o4fj8kx0 168 10 Protect protect VB cord-286923-o4fj8kx0 168 11 Female female JJ cord-286923-o4fj8kx0 168 12 Mice mouse NNS cord-286923-o4fj8kx0 168 13 from from IN cord-286923-o4fj8kx0 168 14 Severe severe JJ cord-286923-o4fj8kx0 168 15 Influenza Influenza NNP cord-286923-o4fj8kx0 168 16 Treatment Treatment NNP cord-286923-o4fj8kx0 168 17 of of IN cord-286923-o4fj8kx0 168 18 multiple multiple JJ cord-286923-o4fj8kx0 168 19 sclerosis sclerosis NN cord-286923-o4fj8kx0 168 20 with with IN cord-286923-o4fj8kx0 168 21 the the DT cord-286923-o4fj8kx0 168 22 pregnancy pregnancy NN cord-286923-o4fj8kx0 168 23 hormone hormone NN cord-286923-o4fj8kx0 168 24 estriol estriol NNP cord-286923-o4fj8kx0 169 1 Vitamin vitamin NN cord-286923-o4fj8kx0 169 2 D d NN cord-286923-o4fj8kx0 169 3 inhibits inhibit VBZ cord-286923-o4fj8kx0 169 4 monocyte monocyte NNP cord-286923-o4fj8kx0 169 5 / / SYM cord-286923-o4fj8kx0 169 6 macrophage macrophage NN cord-286923-o4fj8kx0 169 7 proinflammatory proinflammatory JJ cord-286923-o4fj8kx0 169 8 cytokine cytokine NN cord-286923-o4fj8kx0 169 9 production production NN cord-286923-o4fj8kx0 169 10 by by IN cord-286923-o4fj8kx0 169 11 targeting target VBG cord-286923-o4fj8kx0 169 12 MAPK MAPK NNP cord-286923-o4fj8kx0 169 13 phosphatase-1 phosphatase-1 NNP cord-286923-o4fj8kx0 169 14 Vitamin vitamin NN cord-286923-o4fj8kx0 169 15 D d NN cord-286923-o4fj8kx0 169 16 : : : cord-286923-o4fj8kx0 169 17 A a DT cord-286923-o4fj8kx0 169 18 Steroid Steroid NNP cord-286923-o4fj8kx0 169 19 Hormone hormone NN cord-286923-o4fj8kx0 169 20 with with IN cord-286923-o4fj8kx0 169 21 Progesterone Progesterone NNP cord-286923-o4fj8kx0 169 22 - - HYPH cord-286923-o4fj8kx0 169 23 Like like JJ cord-286923-o4fj8kx0 169 24 Activity activity NN cord-286923-o4fj8kx0 169 25 1 1 CD cord-286923-o4fj8kx0 169 26 alpha alpha NN cord-286923-o4fj8kx0 169 27 , , , cord-286923-o4fj8kx0 169 28 25-Dihydroxyvitamin 25-dihydroxyvitamin CD cord-286923-o4fj8kx0 169 29 D3 D3 NNP cord-286923-o4fj8kx0 169 30 and and CC cord-286923-o4fj8kx0 169 31 24,25-dihydroxyvitamin 24,25-dihydroxyvitamin CD cord-286923-o4fj8kx0 169 32 D3 D3 NNP cord-286923-o4fj8kx0 169 33 in in IN cord-286923-o4fj8kx0 169 34 vitro vitro FW cord-286923-o4fj8kx0 169 35 synthesis synthesis NN cord-286923-o4fj8kx0 169 36 by by IN cord-286923-o4fj8kx0 169 37 human human JJ cord-286923-o4fj8kx0 169 38 decidua decidua NN cord-286923-o4fj8kx0 169 39 and and CC cord-286923-o4fj8kx0 169 40 placenta placenta NN cord-286923-o4fj8kx0 170 1 Does do VBZ cord-286923-o4fj8kx0 170 2 Vitamin vitamin NN cord-286923-o4fj8kx0 170 3 D d NN cord-286923-o4fj8kx0 170 4 Protect protect VB cord-286923-o4fj8kx0 170 5 Against against IN cord-286923-o4fj8kx0 170 6 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 170 7 ? ? . cord-286923-o4fj8kx0 171 1 -Medscape -Medscape . cord-286923-o4fj8kx0 172 1 Vitamin vitamin NN cord-286923-o4fj8kx0 172 2 D d NN cord-286923-o4fj8kx0 172 3 Supplementation supplementation NN cord-286923-o4fj8kx0 172 4 Could Could MD cord-286923-o4fj8kx0 172 5 Possibly possibly RB cord-286923-o4fj8kx0 172 6 Improve improve VB cord-286923-o4fj8kx0 172 7 Clinical clinical JJ cord-286923-o4fj8kx0 172 8 Outcomes Outcomes NNPS cord-286923-o4fj8kx0 172 9 of of IN cord-286923-o4fj8kx0 172 10 Patients patient NNS cord-286923-o4fj8kx0 172 11 Infected infect VBN cord-286923-o4fj8kx0 172 12 with with IN cord-286923-o4fj8kx0 172 13 Coronavirus-2019 Coronavirus-2019 NNP cord-286923-o4fj8kx0 172 14 ( ( -LRB- cord-286923-o4fj8kx0 172 15 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 172 16 ) ) -RRB- cord-286923-o4fj8kx0 172 17 Vitamin vitamin NN cord-286923-o4fj8kx0 172 18 D d NN cord-286923-o4fj8kx0 172 19 and and CC cord-286923-o4fj8kx0 172 20 inflammation inflammation NN cord-286923-o4fj8kx0 172 21 : : : cord-286923-o4fj8kx0 172 22 potential potential JJ cord-286923-o4fj8kx0 172 23 implications implication NNS cord-286923-o4fj8kx0 172 24 for for IN cord-286923-o4fj8kx0 172 25 severity severity NN cord-286923-o4fj8kx0 172 26 of of IN cord-286923-o4fj8kx0 172 27 COVID-19 covid-19 JJ cord-286923-o4fj8kx0 172 28 Vitamin vitamin NN cord-286923-o4fj8kx0 172 29 D D NNP cord-286923-o4fj8kx0 172 30 and and CC cord-286923-o4fj8kx0 172 31 innate innate JJ cord-286923-o4fj8kx0 172 32 and and CC cord-286923-o4fj8kx0 172 33 adaptive adaptive JJ cord-286923-o4fj8kx0 172 34 immunity immunity NN cord-286923-o4fj8kx0 173 1 1,25-Dihydroxyvitamin 1,25-dihydroxyvitamin CD cord-286923-o4fj8kx0 173 2 D3 D3 NNP cord-286923-o4fj8kx0 173 3 curtails curtail VBZ cord-286923-o4fj8kx0 173 4 the the DT cord-286923-o4fj8kx0 173 5 inflammatory inflammatory NN cord-286923-o4fj8kx0 173 6 and and CC cord-286923-o4fj8kx0 173 7 T t NN cord-286923-o4fj8kx0 173 8 cell cell NN cord-286923-o4fj8kx0 173 9 stimulatory stimulatory JJ cord-286923-o4fj8kx0 173 10 capacity capacity NN cord-286923-o4fj8kx0 173 11 of of IN cord-286923-o4fj8kx0 173 12 macrophages macrophage NNS cord-286923-o4fj8kx0 173 13 through through IN cord-286923-o4fj8kx0 173 14 an an DT cord-286923-o4fj8kx0 173 15 IL-10-dependent IL-10-dependent NNP cord-286923-o4fj8kx0 173 16 mechanism mechanism NN cord-286923-o4fj8kx0 173 17 25-Dihydroxyvitamin 25-dihydroxyvitamin CD cord-286923-o4fj8kx0 173 18 D3 D3 NNP cord-286923-o4fj8kx0 173 19 is be VBZ cord-286923-o4fj8kx0 173 20 a a DT cord-286923-o4fj8kx0 173 21 potent potent JJ cord-286923-o4fj8kx0 173 22 suppressor suppressor NN cord-286923-o4fj8kx0 173 23 of of IN cord-286923-o4fj8kx0 173 24 interferon interferon NN cord-286923-o4fj8kx0 173 25 gamma gamma NN cord-286923-o4fj8kx0 173 26 - - HYPH cord-286923-o4fj8kx0 173 27 mediated mediate VBN cord-286923-o4fj8kx0 173 28 macrophage macrophage NN cord-286923-o4fj8kx0 173 29 activation activation NN cord-286923-o4fj8kx0 173 30 Acute Acute NNP cord-286923-o4fj8kx0 173 31 Respiratory respiratory JJ cord-286923-o4fj8kx0 173 32 Tract tract NN cord-286923-o4fj8kx0 173 33 Infection infection NN cord-286923-o4fj8kx0 173 34 and and CC cord-286923-o4fj8kx0 173 35 25-Hydroxyvitamin 25-hydroxyvitamin CD cord-286923-o4fj8kx0 173 36 D d NN cord-286923-o4fj8kx0 173 37 Concentration concentration NN cord-286923-o4fj8kx0 173 38 : : : cord-286923-o4fj8kx0 174 1 A a DT cord-286923-o4fj8kx0 174 2 Systematic Systematic NNP cord-286923-o4fj8kx0 174 3 Review Review NNP cord-286923-o4fj8kx0 174 4 and and CC cord-286923-o4fj8kx0 174 5 Meta Meta NNP cord-286923-o4fj8kx0 174 6 - - HYPH cord-286923-o4fj8kx0 174 7 Analysis Analysis NNP cord-286923-o4fj8kx0 175 1 The the DT cord-286923-o4fj8kx0 175 2 Anti anti JJ cord-286923-o4fj8kx0 175 3 - - JJ cord-286923-o4fj8kx0 175 4 Inflammatory inflammatory JJ cord-286923-o4fj8kx0 175 5 Effects effect NNS cord-286923-o4fj8kx0 175 6 of of IN cord-286923-o4fj8kx0 175 7 Vitamin vitamin NN cord-286923-o4fj8kx0 175 8 D d NN cord-286923-o4fj8kx0 175 9 in in IN cord-286923-o4fj8kx0 175 10 Tumorigenesis Tumorigenesis NNP cord-286923-o4fj8kx0 175 11 Low Low NNP cord-286923-o4fj8kx0 175 12 serum serum NN cord-286923-o4fj8kx0 175 13 25-hydroxyvitamin 25-hydroxyvitamin CD cord-286923-o4fj8kx0 175 14 D d NN cord-286923-o4fj8kx0 175 15 level level NN cord-286923-o4fj8kx0 175 16 : : : cord-286923-o4fj8kx0 175 17 An an DT cord-286923-o4fj8kx0 175 18 independent independent JJ cord-286923-o4fj8kx0 175 19 risk risk NN cord-286923-o4fj8kx0 175 20 factor factor NN cord-286923-o4fj8kx0 175 21 for for IN cord-286923-o4fj8kx0 175 22 tuberculosis tuberculosis NN cord-286923-o4fj8kx0 175 23 ? ? . cord-286923-o4fj8kx0 176 1 Vitamin vitamin NN cord-286923-o4fj8kx0 176 2 D d NN cord-286923-o4fj8kx0 176 3 and and CC cord-286923-o4fj8kx0 176 4 cardiovascular cardiovascular JJ cord-286923-o4fj8kx0 176 5 disease disease NN cord-286923-o4fj8kx0 176 6 : : : cord-286923-o4fj8kx0 177 1 From from IN cord-286923-o4fj8kx0 177 2 atherosclerosis atherosclerosis NN cord-286923-o4fj8kx0 177 3 to to IN cord-286923-o4fj8kx0 177 4 myocardial myocardial JJ cord-286923-o4fj8kx0 177 5 infarction infarction NN cord-286923-o4fj8kx0 177 6 and and CC cord-286923-o4fj8kx0 177 7 stroke stroke NN cord-286923-o4fj8kx0 177 8 Vitamin vitamin NN cord-286923-o4fj8kx0 177 9 D d NN cord-286923-o4fj8kx0 177 10 in in IN cord-286923-o4fj8kx0 177 11 inflammatory inflammatory JJ cord-286923-o4fj8kx0 177 12 bowel bowel NN cord-286923-o4fj8kx0 177 13 disease disease NN cord-286923-o4fj8kx0 177 14 : : : cord-286923-o4fj8kx0 177 15 From from IN cord-286923-o4fj8kx0 177 16 biology biology NN cord-286923-o4fj8kx0 177 17 to to IN cord-286923-o4fj8kx0 177 18 clinical clinical JJ cord-286923-o4fj8kx0 177 19 implications implication NNS cord-286923-o4fj8kx0 177 20 Vitamin vitamin NN cord-286923-o4fj8kx0 177 21 D d NN cord-286923-o4fj8kx0 177 22 as as IN cord-286923-o4fj8kx0 177 23 a a DT cord-286923-o4fj8kx0 177 24 Principal Principal NNP cord-286923-o4fj8kx0 177 25 Factor factor NN cord-286923-o4fj8kx0 177 26 in in IN cord-286923-o4fj8kx0 177 27 Mediating mediate VBG cord-286923-o4fj8kx0 177 28 Rheumatoid Rheumatoid NNP cord-286923-o4fj8kx0 177 29 Arthritis arthritis NN cord-286923-o4fj8kx0 177 30 - - HYPH cord-286923-o4fj8kx0 177 31 Derived derive VBN cord-286923-o4fj8kx0 177 32 Immune Immune NNP cord-286923-o4fj8kx0 177 33 Response response NN cord-286923-o4fj8kx0 177 34 Immunological immunological JJ cord-286923-o4fj8kx0 177 35 role role NN cord-286923-o4fj8kx0 177 36 of of IN cord-286923-o4fj8kx0 177 37 vitamin vitamin NN cord-286923-o4fj8kx0 177 38 D d NN cord-286923-o4fj8kx0 177 39 at at IN cord-286923-o4fj8kx0 177 40 the the DT cord-286923-o4fj8kx0 177 41 maternal maternal JJ cord-286923-o4fj8kx0 177 42 - - HYPH cord-286923-o4fj8kx0 177 43 fetal fetal JJ cord-286923-o4fj8kx0 177 44 interface interface NN cord-286923-o4fj8kx0 177 45 Vitamin vitamin NN cord-286923-o4fj8kx0 177 46 D d NN cord-286923-o4fj8kx0 177 47 Effects effect NNS cord-286923-o4fj8kx0 177 48 on on IN cord-286923-o4fj8kx0 177 49 the the DT cord-286923-o4fj8kx0 177 50 Immune Immune NNP cord-286923-o4fj8kx0 177 51 System System NNP cord-286923-o4fj8kx0 177 52 from from IN cord-286923-o4fj8kx0 177 53 Periconception Periconception NNP cord-286923-o4fj8kx0 177 54 through through IN cord-286923-o4fj8kx0 177 55 Pregnancy Pregnancy NNP cord-286923-o4fj8kx0 177 56 Rheumatic Rheumatic NNP cord-286923-o4fj8kx0 177 57 Disease Disease NNP cord-286923-o4fj8kx0 177 58 and and CC cord-286923-o4fj8kx0 177 59 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 177 60 : : : cord-286923-o4fj8kx0 177 61 Initial Initial NNP cord-286923-o4fj8kx0 177 62 Data Data NNP cord-286923-o4fj8kx0 177 63 from from IN cord-286923-o4fj8kx0 177 64 the the DT cord-286923-o4fj8kx0 177 65 COVID-19 COVID-19 NNP cord-286923-o4fj8kx0 177 66 Global Global NNP cord-286923-o4fj8kx0 177 67 Rheumatology Rheumatology NNP cord-286923-o4fj8kx0 177 68 Alliance Alliance NNP cord-286923-o4fj8kx0 177 69 Provider Provider NNP cord-286923-o4fj8kx0 177 70 Registries Registries NNP cord-286923-o4fj8kx0 177 71 Pregnancy pregnancy NN cord-286923-o4fj8kx0 177 72 in in IN cord-286923-o4fj8kx0 177 73 systemic systemic JJ cord-286923-o4fj8kx0 177 74 sclerosis sclerosis NN cord-286923-o4fj8kx0 178 1 The the DT cord-286923-o4fj8kx0 178 2 immunopathogenesis immunopathogenesis NN cord-286923-o4fj8kx0 178 3 of of IN cord-286923-o4fj8kx0 178 4 fibrosis fibrosis NN cord-286923-o4fj8kx0 178 5 in in IN cord-286923-o4fj8kx0 178 6 systemic systemic JJ cord-286923-o4fj8kx0 178 7 sclerosis sclerosis NN cord-286923-o4fj8kx0 178 8 Anticoagulant Anticoagulant NNP cord-286923-o4fj8kx0 178 9 Treatment Treatment NNP cord-286923-o4fj8kx0 178 10 Is be VBZ cord-286923-o4fj8kx0 178 11 Associated associate VBN cord-286923-o4fj8kx0 178 12 with with IN cord-286923-o4fj8kx0 178 13 Decreased Decreased NNP cord-286923-o4fj8kx0 178 14 Mortality Mortality NNP cord-286923-o4fj8kx0 178 15 in in IN cord-286923-o4fj8kx0 178 16 Severe severe JJ cord-286923-o4fj8kx0 178 17 Coronavirus Coronavirus NNP cord-286923-o4fj8kx0 178 18 Disease Disease NNP