id	sid	tid	token	lemma	pos
cord-285806-363ivs67	1	1	key	key	NN
cord-285806-363ivs67	1	2	:	:	:
cord-285806-363ivs67	2	1	cord-285806	cord-285806	NNP
cord-285806-363ivs67	2	2	-	-	HYPH
cord-285806-363ivs67	2	3	363ivs67	363ivs67	CD
cord-285806-363ivs67	2	4	authors	author	NNS
cord-285806-363ivs67	2	5	:	:	:
cord-285806-363ivs67	2	6	Magro	Magro	NNP
cord-285806-363ivs67	2	7	,	,	,
cord-285806-363ivs67	2	8	Giuseppe	Giuseppe	NNP
cord-285806-363ivs67	2	9	title	title	NN
cord-285806-363ivs67	2	10	:	:	:
cord-285806-363ivs67	2	11	SARS	SARS	NNP
cord-285806-363ivs67	2	12	-	-	HYPH
cord-285806-363ivs67	2	13	CoV-2	CoV-2	NNP
cord-285806-363ivs67	2	14	and	and	CC
cord-285806-363ivs67	2	15	COVID-19	COVID-19	NNP
cord-285806-363ivs67	2	16	:	:	:
cord-285806-363ivs67	2	17	is	be	VBZ
cord-285806-363ivs67	2	18	interleukin-6	interleukin-6	NNP
cord-285806-363ivs67	2	19	(	(	-LRB-
cord-285806-363ivs67	2	20	IL-6	IL-6	NNP
cord-285806-363ivs67	2	21	)	)	-RRB-
cord-285806-363ivs67	2	22	the	the	DT
cord-285806-363ivs67	2	23	'	'	``
cord-285806-363ivs67	2	24	culprit	culprit	NN
cord-285806-363ivs67	2	25	lesion	lesion	NN
cord-285806-363ivs67	2	26	'	'	''
cord-285806-363ivs67	2	27	of	of	IN
cord-285806-363ivs67	2	28	ARDS	ARDS	NNP
cord-285806-363ivs67	2	29	onset	onset	NN
cord-285806-363ivs67	2	30	?	?	.
cord-285806-363ivs67	3	1	What	what	WP
cord-285806-363ivs67	3	2	is	be	VBZ
cord-285806-363ivs67	3	3	there	there	EX
cord-285806-363ivs67	3	4	besides	besides	IN
cord-285806-363ivs67	3	5	Tocilizumab	Tocilizumab	NNP
cord-285806-363ivs67	3	6	?	?	.
cord-285806-363ivs67	4	1	SGP130Fc	sgp130fc	CD
cord-285806-363ivs67	4	2	date	date	NN
cord-285806-363ivs67	4	3	:	:	:
cord-285806-363ivs67	4	4	2020	2020	CD
cord-285806-363ivs67	4	5	-	-	HYPH
cord-285806-363ivs67	4	6	05	05	CD
cord-285806-363ivs67	4	7	-	-	SYM
cord-285806-363ivs67	4	8	14	14	CD
cord-285806-363ivs67	4	9	journal	journal	NN
cord-285806-363ivs67	4	10	:	:	:
cord-285806-363ivs67	5	1	Cytokine	cytokine	NN
cord-285806-363ivs67	5	2	X	x	NN
cord-285806-363ivs67	5	3	DOI	doi	NN
cord-285806-363ivs67	5	4	:	:	:
cord-285806-363ivs67	5	5	10.1016	10.1016	CD
cord-285806-363ivs67	5	6	/	/	SYM
cord-285806-363ivs67	5	7	j.cytox.2020.100029	j.cytox.2020.100029	NN
cord-285806-363ivs67	5	8	sha	sha	NNP
cord-285806-363ivs67	5	9	:	:	:
cord-285806-363ivs67	5	10	c33a3b9c94743d9702fee86ffe707b01366ad511	c33a3b9c94743d9702fee86ffe707b01366ad511	NNP
cord-285806-363ivs67	5	11	doc_id	doc_id	CD
cord-285806-363ivs67	5	12	:	:	:
cord-285806-363ivs67	5	13	285806	285806	CD
cord-285806-363ivs67	5	14	cord_uid	cord_uid	NNS
cord-285806-363ivs67	5	15	:	:	:
cord-285806-363ivs67	5	16	363ivs67	363ivs67	CD
cord-285806-363ivs67	6	1	Since	since	IN
cord-285806-363ivs67	6	2	the	the	DT
cord-285806-363ivs67	6	3	outbreak	outbreak	NN
cord-285806-363ivs67	6	4	of	of	IN
cord-285806-363ivs67	6	5	COVID-19	covid-19	DT
cord-285806-363ivs67	6	6	many	many	JJ
cord-285806-363ivs67	6	7	studies	study	NNS
cord-285806-363ivs67	6	8	have	have	VBP
cord-285806-363ivs67	6	9	been	be	VBN
cord-285806-363ivs67	6	10	published	publish	VBN
cord-285806-363ivs67	6	11	showing	show	VBG
cord-285806-363ivs67	6	12	possible	possible	JJ
cord-285806-363ivs67	6	13	therapies	therapy	NNS
cord-285806-363ivs67	6	14	,	,	,
cord-285806-363ivs67	6	15	here	here	RB
cord-285806-363ivs67	6	16	the	the	DT
cord-285806-363ivs67	6	17	author	author	NN
cord-285806-363ivs67	6	18	discusses	discuss	VBZ
cord-285806-363ivs67	6	19	the	the	DT
cord-285806-363ivs67	6	20	end	end	NN
cord-285806-363ivs67	6	21	of	of	IN
cord-285806-363ivs67	6	22	stage	stage	NN
cord-285806-363ivs67	6	23	disease	disease	NN
cord-285806-363ivs67	6	24	related	relate	VBN
cord-285806-363ivs67	6	25	drugs	drug	NNS
cord-285806-363ivs67	6	26	,	,	,
cord-285806-363ivs67	6	27	like	like	IN
cord-285806-363ivs67	6	28	Tocilizumab	Tocilizumab	NNP
cord-285806-363ivs67	6	29	which	which	WDT
cord-285806-363ivs67	6	30	is	be	VBZ
cord-285806-363ivs67	6	31	currently	currently	RB
cord-285806-363ivs67	6	32	being	be	VBG
cord-285806-363ivs67	6	33	used	use	VBN
cord-285806-363ivs67	6	34	in	in	IN
cord-285806-363ivs67	6	35	ARDS	ARDS	NNP
cord-285806-363ivs67	6	36	patients	patient	NNS
cord-285806-363ivs67	6	37	.	.	.
cord-285806-363ivs67	7	1	In	in	IN
cord-285806-363ivs67	7	2	some	some	DT
cord-285806-363ivs67	7	3	patients	patient	NNS
cord-285806-363ivs67	7	4	,	,	,
cord-285806-363ivs67	7	5	disease	disease	NN
cord-285806-363ivs67	7	6	progression	progression	NN
cord-285806-363ivs67	7	7	leads	lead	VBZ
cord-285806-363ivs67	7	8	to	to	IN
cord-285806-363ivs67	7	9	an	an	DT
cord-285806-363ivs67	7	10	enormous	enormous	JJ
cord-285806-363ivs67	7	11	secretion	secretion	NN
cord-285806-363ivs67	7	12	of	of	IN
cord-285806-363ivs67	7	13	cytokines	cytokine	NNS
cord-285806-363ivs67	7	14	,	,	,
cord-285806-363ivs67	7	15	known	know	VBN
cord-285806-363ivs67	7	16	as	as	IN
cord-285806-363ivs67	7	17	cytokine	cytokine	NN
cord-285806-363ivs67	7	18	storm	storm	NN
cord-285806-363ivs67	7	19	,	,	,
cord-285806-363ivs67	7	20	among	among	IN
cord-285806-363ivs67	7	21	those	those	DT
cord-285806-363ivs67	7	22	cytokines	cytokine	NNS
cord-285806-363ivs67	7	23	IL-6	IL-6	NNP
cord-285806-363ivs67	7	24	plays	play	VBZ
cord-285806-363ivs67	7	25	an	an	DT
cord-285806-363ivs67	7	26	important	important	JJ
cord-285806-363ivs67	7	27	role	role	NN
cord-285806-363ivs67	7	28	.	.	.
cord-285806-363ivs67	8	1	Here	here	RB
cord-285806-363ivs67	8	2	the	the	DT
cord-285806-363ivs67	8	3	author	author	NN
cord-285806-363ivs67	8	4	shows	show	VBZ
cord-285806-363ivs67	8	5	how	how	WRB
cord-285806-363ivs67	8	6	IL-6	IL-6	NNP
cord-285806-363ivs67	8	7	has	have	VBZ
cord-285806-363ivs67	8	8	both	both	CC
cord-285806-363ivs67	8	9	pro	pro	JJ
cord-285806-363ivs67	8	10	and	and	CC
cord-285806-363ivs67	8	11	anti	anti	JJ
cord-285806-363ivs67	8	12	-	-	JJ
cord-285806-363ivs67	8	13	inflammatory	inflammatory	JJ
cord-285806-363ivs67	8	14	properties	property	NNS
cord-285806-363ivs67	8	15	,	,	,
cord-285806-363ivs67	8	16	depending	depend	VBG
cord-285806-363ivs67	8	17	on	on	IN
cord-285806-363ivs67	8	18	the	the	DT
cord-285806-363ivs67	8	19	pathway	pathway	NN
cord-285806-363ivs67	8	20	of	of	IN
cord-285806-363ivs67	8	21	transduction	transduction	NN
cord-285806-363ivs67	8	22	:	:	:
cord-285806-363ivs67	8	23	soluble	soluble	JJ
cord-285806-363ivs67	8	24	(	(	-LRB-
cord-285806-363ivs67	8	25	trans	trans	NN
cord-285806-363ivs67	8	26	-	-	JJ
cord-285806-363ivs67	8	27	signaling	signal	VBG
cord-285806-363ivs67	8	28	)	)	-RRB-
cord-285806-363ivs67	8	29	or	or	CC
cord-285806-363ivs67	8	30	membrane	membrane	NN
cord-285806-363ivs67	8	31	-	-	HYPH
cord-285806-363ivs67	8	32	related	relate	VBN
cord-285806-363ivs67	8	33	(	(	-LRB-
cord-285806-363ivs67	8	34	classic	classic	JJ
cord-285806-363ivs67	8	35	signaling	signaling	NN
cord-285806-363ivs67	8	36	)	)	-RRB-
cord-285806-363ivs67	8	37	,	,	,
cord-285806-363ivs67	8	38	and	and	CC
cord-285806-363ivs67	8	39	suggests	suggest	VBZ
cord-285806-363ivs67	8	40	how	how	WRB
cord-285806-363ivs67	8	41	targeting	target	VBG
cord-285806-363ivs67	8	42	only	only	RB
cord-285806-363ivs67	8	43	the	the	DT
cord-285806-363ivs67	8	44	pro	pro	JJ
cord-285806-363ivs67	8	45	-	-	JJ
cord-285806-363ivs67	8	46	inflammatory	inflammatory	JJ
cord-285806-363ivs67	8	47	pathway	pathway	NN
cord-285806-363ivs67	8	48	,	,	,
cord-285806-363ivs67	8	49	with	with	IN
cord-285806-363ivs67	8	50	SGP130Fc	sgp130fc	CD
cord-285806-363ivs67	8	51	,	,	,
cord-285806-363ivs67	8	52	could	could	MD
cord-285806-363ivs67	8	53	be	be	VB
cord-285806-363ivs67	8	54	a	a	DT
cord-285806-363ivs67	8	55	better	well	JJR
cord-285806-363ivs67	8	56	option	option	NN
cord-285806-363ivs67	8	57	then	then	RB
cord-285806-363ivs67	8	58	targeting	target	VBG
cord-285806-363ivs67	8	59	them	-PRON-	PRP
cord-285806-363ivs67	8	60	both	both	DT
cord-285806-363ivs67	8	61	.	.	.
cord-285806-363ivs67	9	1	Other	other	JJ
cord-285806-363ivs67	9	2	possible	possible	JJ
cord-285806-363ivs67	9	3	IL-6	IL-6	NNP
cord-285806-363ivs67	9	4	pathway	pathway	NN
cord-285806-363ivs67	9	5	inhibitors	inhibitor	NNS
cord-285806-363ivs67	9	6	such	such	JJ
cord-285806-363ivs67	9	7	as	as	IN
cord-285806-363ivs67	9	8	Ruxolitinib	Ruxolitinib	NNP
cord-285806-363ivs67	9	9	and	and	CC
cord-285806-363ivs67	9	10	Baricinitib	Baricinitib	NNP
cord-285806-363ivs67	9	11	are	be	VBP
cord-285806-363ivs67	9	12	then	then	RB
cord-285806-363ivs67	9	13	analyzed	analyze	VBN
cord-285806-363ivs67	9	14	,	,	,
cord-285806-363ivs67	9	15	underlying	underlie	VBG
cord-285806-363ivs67	9	16	how	how	WRB
cord-285806-363ivs67	9	17	they	-PRON-	PRP
cord-285806-363ivs67	9	18	lack	lack	VBP
cord-285806-363ivs67	9	19	the	the	DT
cord-285806-363ivs67	9	20	benefit	benefit	NN
cord-285806-363ivs67	9	21	of	of	IN
cord-285806-363ivs67	9	22	targeting	target	VBG
cord-285806-363ivs67	9	23	only	only	RB
cord-285806-363ivs67	9	24	the	the	DT
cord-285806-363ivs67	9	25	pro	pro	JJ
cord-285806-363ivs67	9	26	-	-	JJ
cord-285806-363ivs67	9	27	inflammatory	inflammatory	JJ
cord-285806-363ivs67	9	28	pathway	pathway	NN
cord-285806-363ivs67	9	29	.	.	.
cord-285806-363ivs67	10	1	Coronaviruses	coronaviruse	NNS
cord-285806-363ivs67	10	2	are	be	VBP
cord-285806-363ivs67	10	3	enveloped	envelop	VBN
cord-285806-363ivs67	10	4	,	,	,
cord-285806-363ivs67	10	5	positive	positive	JJ
cord-285806-363ivs67	10	6	-	-	HYPH
cord-285806-363ivs67	10	7	sense	sense	NN
cord-285806-363ivs67	10	8	,	,	,
cord-285806-363ivs67	10	9	single	single	JJ
cord-285806-363ivs67	10	10	stranded	strand	VBN
cord-285806-363ivs67	10	11	RNA	RNA	NNP
cord-285806-363ivs67	10	12	viruses	virus	NNS
cord-285806-363ivs67	10	13	that	that	WDT
cord-285806-363ivs67	10	14	are	be	VBP
cord-285806-363ivs67	10	15	distributed	distribute	VBN
cord-285806-363ivs67	10	16	broadly	broadly	RB
cord-285806-363ivs67	10	17	among	among	IN
cord-285806-363ivs67	10	18	humans	human	NNS
cord-285806-363ivs67	10	19	which	which	WDT
cord-285806-363ivs67	10	20	cause	cause	VBP
cord-285806-363ivs67	10	21	respiratory	respiratory	JJ
cord-285806-363ivs67	10	22	,	,	,
cord-285806-363ivs67	10	23	enteric	enteric	JJ
cord-285806-363ivs67	10	24	,	,	,
cord-285806-363ivs67	10	25	hepatic	hepatic	JJ
cord-285806-363ivs67	10	26	,	,	,
cord-285806-363ivs67	10	27	and	and	CC
cord-285806-363ivs67	10	28	neurologic	neurologic	JJ
cord-285806-363ivs67	10	29	diseases	disease	NNS
cord-285806-363ivs67	10	30	1	1	CD
cord-285806-363ivs67	10	31	.	.	.
cord-285806-363ivs67	11	1	SARS	SARS	NNP
cord-285806-363ivs67	11	2	-	-	HYPH
cord-285806-363ivs67	11	3	CoV-2	CoV-2	NNP
cord-285806-363ivs67	11	4	is	be	VBZ
cord-285806-363ivs67	11	5	the	the	DT
cord-285806-363ivs67	11	6	agent	agent	NN
cord-285806-363ivs67	11	7	responsible	responsible	JJ
cord-285806-363ivs67	11	8	for	for	IN
cord-285806-363ivs67	11	9	the	the	DT
cord-285806-363ivs67	11	10	COVID-19	COVID-19	NNP
cord-285806-363ivs67	11	11	,	,	,
cord-285806-363ivs67	11	12	it	-PRON-	PRP
cord-285806-363ivs67	11	13	is	be	VBZ
cord-285806-363ivs67	11	14	a	a	DT
cord-285806-363ivs67	11	15	beta	beta	JJ
cord-285806-363ivs67	11	16	coronavirus	coronavirus	NN
cord-285806-363ivs67	11	17	of	of	IN
cord-285806-363ivs67	11	18	group	group	NN
cord-285806-363ivs67	11	19	2B	2b	CD
cord-285806-363ivs67	11	20	with	with	IN
cord-285806-363ivs67	11	21	over	over	IN
cord-285806-363ivs67	11	22	70	70	CD
cord-285806-363ivs67	11	23	%	%	NN
cord-285806-363ivs67	11	24	similarity	similarity	NN
cord-285806-363ivs67	11	25	in	in	IN
cord-285806-363ivs67	11	26	genetic	genetic	JJ
cord-285806-363ivs67	11	27	sequence	sequence	NN
cord-285806-363ivs67	11	28	to	to	IN
cord-285806-363ivs67	11	29	SARS	SARS	NNP
cord-285806-363ivs67	11	30	-	-	HYPH
cord-285806-363ivs67	11	31	CoV-1	CoV-1	NNP
cord-285806-363ivs67	11	32	2	2	CD
cord-285806-363ivs67	11	33	.	.	.
cord-285806-363ivs67	12	1	Acute	acute	JJ
cord-285806-363ivs67	12	2	respiratory	respiratory	JJ
cord-285806-363ivs67	12	3	distress	distress	NN
cord-285806-363ivs67	12	4	syndrome	syndrome	NN
cord-285806-363ivs67	12	5	(	(	-LRB-
cord-285806-363ivs67	12	6	ARDS	ARDS	NNP
cord-285806-363ivs67	12	7	)	)	-RRB-
cord-285806-363ivs67	12	8	is	be	VBZ
cord-285806-363ivs67	12	9	not	not	RB
cord-285806-363ivs67	12	10	an	an	DT
cord-285806-363ivs67	12	11	uncommon	uncommon	JJ
cord-285806-363ivs67	12	12	complication	complication	NN
cord-285806-363ivs67	12	13	when	when	WRB
cord-285806-363ivs67	12	14	disease	disease	NN
cord-285806-363ivs67	12	15	ca	can	MD
cord-285806-363ivs67	12	16	n't	not	RB
cord-285806-363ivs67	12	17	be	be	VB
cord-285806-363ivs67	12	18	controlled	control	VBN
cord-285806-363ivs67	12	19	3	3	CD
cord-285806-363ivs67	12	20	,	,	,
cord-285806-363ivs67	12	21	the	the	DT
cord-285806-363ivs67	12	22	percentage	percentage	NN
cord-285806-363ivs67	12	23	of	of	IN
cord-285806-363ivs67	12	24	patients	patient	NNS
cord-285806-363ivs67	12	25	requiring	require	VBG
cord-285806-363ivs67	12	26	ARDS	ARDS	NNP
cord-285806-363ivs67	12	27	treatment	treatment	NN
cord-285806-363ivs67	12	28	is	be	VBZ
cord-285806-363ivs67	12	29	about	about	RB
cord-285806-363ivs67	12	30	10	10	CD
cord-285806-363ivs67	12	31	%	%	NN
cord-285806-363ivs67	12	32	for	for	IN
cord-285806-363ivs67	12	33	those	those	DT
cord-285806-363ivs67	12	34	who	who	WP
cord-285806-363ivs67	12	35	are	be	VBP
cord-285806-363ivs67	12	36	actively	actively	RB
cord-285806-363ivs67	12	37	infected	infect	VBN
cord-285806-363ivs67	12	38	.	.	.
cord-285806-363ivs67	13	1	Total	total	JJ
cord-285806-363ivs67	13	2	white	white	JJ
cord-285806-363ivs67	13	3	blood	blood	NN
cord-285806-363ivs67	13	4	count	count	NN
cord-285806-363ivs67	13	5	,	,	,
cord-285806-363ivs67	13	6	lymphocytes	lymphocyte	NNS
cord-285806-363ivs67	13	7	,	,	,
cord-285806-363ivs67	13	8	and	and	CC
cord-285806-363ivs67	13	9	platelets	platelet	NNS
cord-285806-363ivs67	13	10	are	be	VBP
cord-285806-363ivs67	13	11	lower	low	JJR
cord-285806-363ivs67	13	12	than	than	IN
cord-285806-363ivs67	13	13	the	the	DT
cord-285806-363ivs67	13	14	average	average	NN
cord-285806-363ivs67	13	15	with	with	IN
cord-285806-363ivs67	13	16	extended	extended	JJ
cord-285806-363ivs67	13	17	activated	activate	VBN
cord-285806-363ivs67	13	18	thromboplastin	thromboplastin	NNP
cord-285806-363ivs67	13	19	time	time	NN
cord-285806-363ivs67	13	20	,	,	,
cord-285806-363ivs67	13	21	increased	increase	VBN
cord-285806-363ivs67	13	22	C	c	NN
cord-285806-363ivs67	13	23	-	-	HYPH
cord-285806-363ivs67	13	24	reactive	reactive	JJ
cord-285806-363ivs67	13	25	protein	protein	NN
cord-285806-363ivs67	13	26	and	and	CC
cord-285806-363ivs67	13	27	muscle	muscle	NN
cord-285806-363ivs67	13	28	enzyme	enzyme	NN
cord-285806-363ivs67	13	29	level	level	NN
cord-285806-363ivs67	13	30	.	.	.
cord-285806-363ivs67	14	1	Lymphocytes	lymphocyte	NNS
cord-285806-363ivs67	14	2	decrease	decrease	VBP
cord-285806-363ivs67	14	3	with	with	IN
cord-285806-363ivs67	14	4	diseases	disease	NNS
cord-285806-363ivs67	14	5	progression	progression	NN
cord-285806-363ivs67	14	6	.	.	.
cord-285806-363ivs67	15	1	Secretion	secretion	NN
cord-285806-363ivs67	15	2	of	of	IN
cord-285806-363ivs67	15	3	cytokine	cytokine	NN
cord-285806-363ivs67	15	4	,	,	,
cord-285806-363ivs67	15	5	such	such	JJ
cord-285806-363ivs67	15	6	as	as	IN
cord-285806-363ivs67	15	7	IL1B	il1b	NN
cord-285806-363ivs67	15	8	,	,	,
cord-285806-363ivs67	15	9	IL1RA	IL1RA	NNP
cord-285806-363ivs67	15	10	,	,	,
cord-285806-363ivs67	15	11	IL6	IL6	NNP
cord-285806-363ivs67	15	12	,	,	,
cord-285806-363ivs67	15	13	IL7	IL7	NNP
cord-285806-363ivs67	15	14	,	,	,
cord-285806-363ivs67	15	15	IL8	IL8	NNP
cord-285806-363ivs67	15	16	,	,	,
cord-285806-363ivs67	15	17	known	know	VBN
cord-285806-363ivs67	15	18	as	as	IN
cord-285806-363ivs67	15	19	cytokine	cytokine	NN
cord-285806-363ivs67	15	20	storm	storm	NN
cord-285806-363ivs67	15	21	,	,	,
cord-285806-363ivs67	15	22	is	be	VBZ
cord-285806-363ivs67	15	23	associated	associate	VBN
cord-285806-363ivs67	15	24	with	with	IN
cord-285806-363ivs67	15	25	disease	disease	NN
cord-285806-363ivs67	15	26	severity	severity	NN
cord-285806-363ivs67	15	27	3	3	CD
cord-285806-363ivs67	15	28	,	,	,
cord-285806-363ivs67	15	29	4	4	CD
cord-285806-363ivs67	15	30	.	.	.
cord-285806-363ivs67	16	1	Therapeutic	therapeutic	JJ
cord-285806-363ivs67	16	2	choices	choice	NNS
cord-285806-363ivs67	16	3	once	once	IN
cord-285806-363ivs67	16	4	disease	disease	NN
cord-285806-363ivs67	16	5	has	have	VBZ
cord-285806-363ivs67	16	6	progressed	progress	VBN
cord-285806-363ivs67	16	7	will	will	MD
cord-285806-363ivs67	16	8	be	be	VB
cord-285806-363ivs67	16	9	discussed	discuss	VBN
cord-285806-363ivs67	16	10	here	here	RB
cord-285806-363ivs67	16	11	.	.	.
cord-285806-363ivs67	17	1	SARS	SARS	NNP
cord-285806-363ivs67	17	2	-	-	HYPH
cord-285806-363ivs67	17	3	CoV-1	CoV-1	NNP
cord-285806-363ivs67	17	4	,	,	,
cord-285806-363ivs67	17	5	MERS	MERS	NNP
cord-285806-363ivs67	17	6	-	-	HYPH
cord-285806-363ivs67	17	7	CoV	CoV	NNP
cord-285806-363ivs67	17	8	and	and	CC
cord-285806-363ivs67	17	9	SARS	SARS	NNP
cord-285806-363ivs67	17	10	-	-	HYPH
cord-285806-363ivs67	17	11	CoV-2	CoV-2	NNP
cord-285806-363ivs67	17	12	show	show	VBP
cord-285806-363ivs67	17	13	a	a	DT
cord-285806-363ivs67	17	14	relatively	relatively	RB
cord-285806-363ivs67	17	15	higher	high	JJR
cord-285806-363ivs67	17	16	mortality	mortality	NN
cord-285806-363ivs67	17	17	rates	rate	NNS
cord-285806-363ivs67	17	18	then	then	RB
cord-285806-363ivs67	17	19	other	other	JJ
cord-285806-363ivs67	17	20	coronaviruses	coronaviruse	NNS
cord-285806-363ivs67	17	21	,	,	,
cord-285806-363ivs67	17	22	all	all	DT
cord-285806-363ivs67	17	23	of	of	IN
cord-285806-363ivs67	17	24	which	which	WDT
cord-285806-363ivs67	17	25	are	be	VBP
cord-285806-363ivs67	17	26	associated	associate	VBN
cord-285806-363ivs67	17	27	with	with	IN
cord-285806-363ivs67	17	28	the	the	DT
cord-285806-363ivs67	17	29	presence	presence	NN
cord-285806-363ivs67	17	30	of	of	IN
cord-285806-363ivs67	17	31	a	a	DT
cord-285806-363ivs67	17	32	cytokine	cytokine	NN
cord-285806-363ivs67	17	33	storm	storm	NN
cord-285806-363ivs67	17	34	,	,	,
cord-285806-363ivs67	17	35	this	this	DT
cord-285806-363ivs67	17	36	might	may	MD
cord-285806-363ivs67	17	37	suggest	suggest	VB
cord-285806-363ivs67	17	38	that	that	IN
cord-285806-363ivs67	17	39	inflammatory	inflammatory	JJ
cord-285806-363ivs67	17	40	responses	response	NNS
cord-285806-363ivs67	17	41	play	play	VBP
cord-285806-363ivs67	17	42	a	a	DT
cord-285806-363ivs67	17	43	role	role	NN
cord-285806-363ivs67	17	44	in	in	IN
cord-285806-363ivs67	17	45	the	the	DT
cord-285806-363ivs67	17	46	pathogenesis	pathogenesis	NN
cord-285806-363ivs67	17	47	.	.	.
cord-285806-363ivs67	18	1	If	if	IN
cord-285806-363ivs67	18	2	that	that	DT
cord-285806-363ivs67	18	3	is	be	VBZ
cord-285806-363ivs67	18	4	the	the	DT
cord-285806-363ivs67	18	5	case	case	NN
cord-285806-363ivs67	18	6	,	,	,
cord-285806-363ivs67	18	7	targeting	target	VBG
cord-285806-363ivs67	18	8	the	the	DT
cord-285806-363ivs67	18	9	coronavirus	coronavirus	NN
cord-285806-363ivs67	18	10	alone	alone	RB
cord-285806-363ivs67	18	11	with	with	IN
cord-285806-363ivs67	18	12	antiviral	antiviral	JJ
cord-285806-363ivs67	18	13	therapy	therapy	NN
cord-285806-363ivs67	18	14	might	may	MD
cord-285806-363ivs67	18	15	not	not	RB
cord-285806-363ivs67	18	16	be	be	VB
cord-285806-363ivs67	18	17	sufficient	sufficient	JJ
cord-285806-363ivs67	18	18	to	to	TO
cord-285806-363ivs67	18	19	reverse	reverse	VB
cord-285806-363ivs67	18	20	highly	highly	RB
cord-285806-363ivs67	18	21	pathogenic	pathogenic	JJ
cord-285806-363ivs67	18	22	infections	infection	NNS
cord-285806-363ivs67	18	23	5	5	CD
cord-285806-363ivs67	18	24	.	.	.
cord-285806-363ivs67	19	1	These	these	DT
cord-285806-363ivs67	19	2	observations	observation	NNS
cord-285806-363ivs67	19	3	led	lead	VBD
cord-285806-363ivs67	19	4	to	to	TO
cord-285806-363ivs67	19	5	explore	explore	VB
cord-285806-363ivs67	19	6	the	the	DT
cord-285806-363ivs67	19	7	usage	usage	NN
cord-285806-363ivs67	19	8	of	of	IN
cord-285806-363ivs67	19	9	therapies	therapy	NNS
cord-285806-363ivs67	19	10	that	that	WDT
cord-285806-363ivs67	19	11	included	include	VBD
cord-285806-363ivs67	19	12	interferons	interferon	NNS
cord-285806-363ivs67	19	13	type	type	NN
cord-285806-363ivs67	19	14	I	-PRON-	PRP
cord-285806-363ivs67	19	15	and	and	CC
cord-285806-363ivs67	19	16	II	II	NNP
cord-285806-363ivs67	19	17	.	.	.
cord-285806-363ivs67	20	1	Interferon	interferon	NN
cord-285806-363ivs67	20	2	beta	beta	NN
cord-285806-363ivs67	20	3	displayed	display	VBD
cord-285806-363ivs67	20	4	the	the	DT
cord-285806-363ivs67	20	5	best	good	JJS
cord-285806-363ivs67	20	6	efficacy	efficacy	NN
cord-285806-363ivs67	20	7	in	in	IN
cord-285806-363ivs67	20	8	reducing	reduce	VBG
cord-285806-363ivs67	20	9	MERS	MERS	NNP
cord-285806-363ivs67	20	10	-	-	HYPH
cord-285806-363ivs67	20	11	CoV	cov	NN
cord-285806-363ivs67	20	12	replication	replication	NN
cord-285806-363ivs67	20	13	in	in	IN
cord-285806-363ivs67	20	14	tissue	tissue	NN
cord-285806-363ivs67	20	15	culture	culture	NN
cord-285806-363ivs67	20	16	6	6	CD
cord-285806-363ivs67	20	17	,	,	,
cord-285806-363ivs67	20	18	7	7	CD
cord-285806-363ivs67	20	19	.	.	.
cord-285806-363ivs67	21	1	A	a	DT
cord-285806-363ivs67	21	2	randomized	randomized	JJ
cord-285806-363ivs67	21	3	control	control	NN
cord-285806-363ivs67	21	4	trial	trial	NN
cord-285806-363ivs67	21	5	is	be	VBZ
cord-285806-363ivs67	21	6	ongoing	ongoing	JJ
cord-285806-363ivs67	21	7	in	in	IN
cord-285806-363ivs67	21	8	South	South	NNP
cord-285806-363ivs67	21	9	Arabia	Arabia	NNP
cord-285806-363ivs67	21	10	(	(	-LRB-
cord-285806-363ivs67	21	11	MIRACLE	MIRACLE	NNP
cord-285806-363ivs67	21	12	Trial	Trial	NNP
cord-285806-363ivs67	21	13	)	)	-RRB-
cord-285806-363ivs67	21	14	to	to	TO
cord-285806-363ivs67	21	15	determine	determine	VB
cord-285806-363ivs67	21	16	whether	whether	IN
cord-285806-363ivs67	21	17	the	the	DT
cord-285806-363ivs67	21	18	combination	combination	NN
cord-285806-363ivs67	21	19	of	of	IN
cord-285806-363ivs67	21	20	antivirals	antiviral	NNS
cord-285806-363ivs67	21	21	used	use	VBN
cord-285806-363ivs67	21	22	in	in	IN
cord-285806-363ivs67	21	23	HIV	HIV	NNP
cord-285806-363ivs67	21	24	infection	infection	NN
cord-285806-363ivs67	21	25	such	such	JJ
cord-285806-363ivs67	21	26	as	as	IN
cord-285806-363ivs67	21	27	Lopinavir	Lopinavir	NNP
cord-285806-363ivs67	21	28	/	/	SYM
cord-285806-363ivs67	21	29	Ritonavir	Ritonavir	NNP
cord-285806-363ivs67	21	30	and	and	CC
cord-285806-363ivs67	21	31	Interferon	Interferon	NNP
cord-285806-363ivs67	21	32	beta	beta	NN
cord-285806-363ivs67	21	33	could	could	MD
cord-285806-363ivs67	21	34	improve	improve	VB
cord-285806-363ivs67	21	35	clinical	clinical	JJ
cord-285806-363ivs67	21	36	outcomes	outcome	NNS
cord-285806-363ivs67	21	37	in	in	IN
cord-285806-363ivs67	21	38	MERS	MERS	NNP
cord-285806-363ivs67	21	39	-	-	HYPH
cord-285806-363ivs67	21	40	CoV	CoV	NNP
cord-285806-363ivs67	21	41	infections	infection	NNS
cord-285806-363ivs67	21	42	8	8	CD
cord-285806-363ivs67	21	43	.	.	.
cord-285806-363ivs67	22	1	In	in	IN
cord-285806-363ivs67	22	2	a	a	DT
cord-285806-363ivs67	22	3	humanized	humanized	JJ
cord-285806-363ivs67	22	4	transgenic	transgenic	JJ
cord-285806-363ivs67	22	5	mouse	mouse	NN
cord-285806-363ivs67	22	6	MERS	MERS	NNP
cord-285806-363ivs67	22	7	-	-	HYPH
cord-285806-363ivs67	22	8	CoV	CoV	NNP
cord-285806-363ivs67	22	9	infection	infection	NN
cord-285806-363ivs67	22	10	model	model	NN
cord-285806-363ivs67	22	11	,	,	,
cord-285806-363ivs67	22	12	Remdesivir	Remdesivir	NNP
cord-285806-363ivs67	22	13	(	(	-LRB-
cord-285806-363ivs67	22	14	a	a	DT
cord-285806-363ivs67	22	15	drug	drug	NN
cord-285806-363ivs67	22	16	already	already	RB
cord-285806-363ivs67	22	17	being	be	VBG
cord-285806-363ivs67	22	18	used	use	VBN
cord-285806-363ivs67	22	19	against	against	IN
cord-285806-363ivs67	22	20	SARS	SARS	NNP
cord-285806-363ivs67	22	21	-	-	HYPH
cord-285806-363ivs67	22	22	CoV-2	CoV-2	NNP
cord-285806-363ivs67	22	23	in	in	IN
cord-285806-363ivs67	22	24	patients	patient	NNS
cord-285806-363ivs67	22	25	with	with	IN
cord-285806-363ivs67	22	26	severe	severe	JJ
cord-285806-363ivs67	22	27	and	and	CC
cord-285806-363ivs67	22	28	moderate	moderate	JJ
cord-285806-363ivs67	22	29	disease	disease	NN
cord-285806-363ivs67	22	30	,	,	,
cord-285806-363ivs67	22	31	GS	gs	NN
cord-285806-363ivs67	22	32	-	-	HYPH
cord-285806-363ivs67	22	33	US-540	US-540	NNP
cord-285806-363ivs67	22	34	-	-	HYPH
cord-285806-363ivs67	22	35	5773/4	5773/4	CD
cord-285806-363ivs67	22	36	Studies	Studies	NNPS
cord-285806-363ivs67	22	37	)	)	-RRB-
cord-285806-363ivs67	22	38	showed	show	VBD
cord-285806-363ivs67	22	39	more	more	JJR
cord-285806-363ivs67	22	40	activity	activity	NN
cord-285806-363ivs67	22	41	and	and	CC
cord-285806-363ivs67	22	42	efficacy	efficacy	NN
cord-285806-363ivs67	22	43	in	in	IN
cord-285806-363ivs67	22	44	prophylactic	prophylactic	JJ
cord-285806-363ivs67	22	45	and	and	CC
cord-285806-363ivs67	22	46	therapeutic	therapeutic	JJ
cord-285806-363ivs67	22	47	use	use	NN
cord-285806-363ivs67	22	48	then	then	RB
cord-285806-363ivs67	22	49	the	the	DT
cord-285806-363ivs67	22	50	combination	combination	NN
cord-285806-363ivs67	22	51	of	of	IN
cord-285806-363ivs67	22	52	Lopinavir	Lopinavir	NNP
cord-285806-363ivs67	22	53	/	/	SYM
cord-285806-363ivs67	22	54	Ritonavir	Ritonavir	NNP
cord-285806-363ivs67	22	55	and	and	CC
cord-285806-363ivs67	22	56	Interferon	Interferon	NNP
cord-285806-363ivs67	22	57	beta	beta	NN
cord-285806-363ivs67	22	58	9	9	CD
cord-285806-363ivs67	22	59	,	,	,
cord-285806-363ivs67	22	60	this	this	DT
cord-285806-363ivs67	22	61	points	point	NNS
cord-285806-363ivs67	22	62	towards	towards	IN
cord-285806-363ivs67	22	63	the	the	DT
cord-285806-363ivs67	22	64	necessity	necessity	NN
cord-285806-363ivs67	22	65	to	to	TO
cord-285806-363ivs67	22	66	explore	explore	VB
cord-285806-363ivs67	22	67	other	other	JJ
cord-285806-363ivs67	22	68	options	option	NNS
cord-285806-363ivs67	22	69	regarding	regard	VBG
cord-285806-363ivs67	22	70	immune	immune	JJ
cord-285806-363ivs67	22	71	system	system	NN
cord-285806-363ivs67	22	72	modulation	modulation	NN
cord-285806-363ivs67	22	73	and	and	CC
cord-285806-363ivs67	22	74	how	how	WRB
cord-285806-363ivs67	22	75	control	control	NN
cord-285806-363ivs67	22	76	of	of	IN
cord-285806-363ivs67	22	77	viraemia	viraemia	NN
cord-285806-363ivs67	22	78	is	be	VBZ
cord-285806-363ivs67	22	79	also	also	RB
cord-285806-363ivs67	22	80	essential	essential	JJ
cord-285806-363ivs67	22	81	.	.	.
cord-285806-363ivs67	23	1	The	the	DT
cord-285806-363ivs67	23	2	use	use	NN
cord-285806-363ivs67	23	3	of	of	IN
cord-285806-363ivs67	23	4	immunosuppressants	immunosuppressant	NNS
cord-285806-363ivs67	23	5	like	like	IN
cord-285806-363ivs67	23	6	corticosteroids	corticosteroid	NNS
cord-285806-363ivs67	23	7	is	be	VBZ
cord-285806-363ivs67	23	8	quite	quite	RB
cord-285806-363ivs67	23	9	controversial	controversial	JJ
cord-285806-363ivs67	23	10	,	,	,
cord-285806-363ivs67	23	11	for	for	IN
cord-285806-363ivs67	23	12	some	some	DT
cord-285806-363ivs67	23	13	it	-PRON-	PRP
cord-285806-363ivs67	23	14	may	may	MD
cord-285806-363ivs67	23	15	be	be	VB
cord-285806-363ivs67	23	16	reasonable	reasonable	JJ
cord-285806-363ivs67	23	17	to	to	TO
cord-285806-363ivs67	23	18	counteract	counteract	VB
cord-285806-363ivs67	23	19	the	the	DT
cord-285806-363ivs67	23	20	effect	effect	NN
cord-285806-363ivs67	23	21	of	of	IN
cord-285806-363ivs67	23	22	cytokine	cytokine	NN
cord-285806-363ivs67	23	23	storm	storm	NN
cord-285806-363ivs67	23	24	induced	induce	VBN
cord-285806-363ivs67	23	25	by	by	IN
cord-285806-363ivs67	23	26	the	the	DT
cord-285806-363ivs67	23	27	SARS	SARS	NNP
cord-285806-363ivs67	23	28	-	-	HYPH
cord-285806-363ivs67	23	29	CoV-2	CoV-2	NNP
cord-285806-363ivs67	23	30	.	.	.
cord-285806-363ivs67	24	1	Although	although	IN
cord-285806-363ivs67	24	2	the	the	DT
cord-285806-363ivs67	24	3	recent	recent	JJ
cord-285806-363ivs67	24	4	open	open	JJ
cord-285806-363ivs67	24	5	label	label	NN
cord-285806-363ivs67	24	6	study	study	NN
cord-285806-363ivs67	24	7	from	from	IN
cord-285806-363ivs67	24	8	Wu	Wu	NNP
cord-285806-363ivs67	24	9	and	and	CC
cord-285806-363ivs67	24	10	colleagues	colleague	NNS
cord-285806-363ivs67	24	11	showed	show	VBD
cord-285806-363ivs67	24	12	a	a	DT
cord-285806-363ivs67	24	13	benefit	benefit	NN
cord-285806-363ivs67	24	14	for	for	IN
cord-285806-363ivs67	24	15	corticosteroids	corticosteroid	NNS
cord-285806-363ivs67	24	16	,	,	,
cord-285806-363ivs67	24	17	for	for	IN
cord-285806-363ivs67	24	18	now	now	RB
cord-285806-363ivs67	24	19	clinical	clinical	JJ
cord-285806-363ivs67	24	20	evidence	evidence	NN
cord-285806-363ivs67	24	21	does	do	VBZ
cord-285806-363ivs67	24	22	not	not	RB
cord-285806-363ivs67	24	23	support	support	VB
cord-285806-363ivs67	24	24	corticosteroid	corticosteroid	NN
cord-285806-363ivs67	24	25	treatment	treatment	NN
cord-285806-363ivs67	24	26	for	for	IN
cord-285806-363ivs67	24	27	SARS	SARS	NNP
cord-285806-363ivs67	24	28	-	-	HYPH
cord-285806-363ivs67	24	29	CoV-1	CoV-1	NNP
cord-285806-363ivs67	24	30	lung	lung	NN
cord-285806-363ivs67	24	31	injury	injury	NN
cord-285806-363ivs67	24	32	,	,	,
cord-285806-363ivs67	24	33	as	as	IN
cord-285806-363ivs67	24	34	it	-PRON-	PRP
cord-285806-363ivs67	24	35	could	could	MD
cord-285806-363ivs67	24	36	result	result	VB
cord-285806-363ivs67	24	37	in	in	IN
cord-285806-363ivs67	24	38	delayed	delay	VBN
cord-285806-363ivs67	24	39	viral	viral	JJ
cord-285806-363ivs67	24	40	clearence	clearence	NN
cord-285806-363ivs67	24	41	10	10	CD
cord-285806-363ivs67	24	42	,	,	,
cord-285806-363ivs67	24	43	11	11	CD
cord-285806-363ivs67	24	44	.	.	.
cord-285806-363ivs67	25	1	IL-6	IL-6	NNP
cord-285806-363ivs67	25	2	can	can	MD
cord-285806-363ivs67	25	3	be	be	VB
cord-285806-363ivs67	25	4	produced	produce	VBN
cord-285806-363ivs67	25	5	by	by	IN
cord-285806-363ivs67	25	6	almost	almost	RB
cord-285806-363ivs67	25	7	all	all	DT
cord-285806-363ivs67	25	8	stromal	stromal	JJ
cord-285806-363ivs67	25	9	cells	cell	NNS
cord-285806-363ivs67	25	10	and	and	CC
cord-285806-363ivs67	25	11	by	by	IN
cord-285806-363ivs67	25	12	immune	immune	JJ
cord-285806-363ivs67	25	13	system	system	NN
cord-285806-363ivs67	25	14	cells	cell	NNS
cord-285806-363ivs67	25	15	,	,	,
cord-285806-363ivs67	25	16	such	such	JJ
cord-285806-363ivs67	25	17	as	as	IN
cord-285806-363ivs67	25	18	B	b	NN
cord-285806-363ivs67	25	19	lymphocytes	lymphocyte	NNS
cord-285806-363ivs67	25	20	,	,	,
cord-285806-363ivs67	25	21	T	t	NN
cord-285806-363ivs67	25	22	lymphocytes	lymphocyte	NNS
cord-285806-363ivs67	25	23	,	,	,
cord-285806-363ivs67	25	24	macrophages	macrophage	NNS
cord-285806-363ivs67	25	25	,	,	,
cord-285806-363ivs67	25	26	dendritic	dendritic	JJ
cord-285806-363ivs67	25	27	cells	cell	NNS
cord-285806-363ivs67	25	28	,	,	,
cord-285806-363ivs67	25	29	monocytes	monocyte	NNS
cord-285806-363ivs67	25	30	,	,	,
cord-285806-363ivs67	25	31	mast	mast	NN
cord-285806-363ivs67	25	32	cells	cell	NNS
cord-285806-363ivs67	25	33	and	and	CC
cord-285806-363ivs67	25	34	many	many	JJ
cord-285806-363ivs67	25	35	non	non	NNS
cord-285806-363ivs67	25	36	-	-	NNS
cord-285806-363ivs67	25	37	lymphocytes	lymphocyte	NNS
cord-285806-363ivs67	25	38	,	,	,
cord-285806-363ivs67	25	39	such	such	JJ
cord-285806-363ivs67	25	40	as	as	IN
cord-285806-363ivs67	25	41	fibroblast	fibroblast	NN
cord-285806-363ivs67	25	42	and	and	CC
cord-285806-363ivs67	25	43	endothelial	endothelial	JJ
cord-285806-363ivs67	25	44	cells	cell	NNS
cord-285806-363ivs67	25	45	12	12	CD
cord-285806-363ivs67	25	46	.	.	.
cord-285806-363ivs67	26	1	Main	main	JJ
cord-285806-363ivs67	26	2	activators	activator	NNS
cord-285806-363ivs67	26	3	of	of	IN
cord-285806-363ivs67	26	4	the	the	DT
cord-285806-363ivs67	26	5	Interleuking-6	Interleuking-6	NNP
cord-285806-363ivs67	26	6	(	(	-LRB-
cord-285806-363ivs67	26	7	IL-6	IL-6	NNP
cord-285806-363ivs67	26	8	)	)	-RRB-
cord-285806-363ivs67	26	9	expression	expression	NN
cord-285806-363ivs67	26	10	are	be	VBP
cord-285806-363ivs67	26	11	IL-1beta	il-1beta	JJ
cord-285806-363ivs67	26	12	and	and	CC
cord-285806-363ivs67	26	13	tumor	tumor	NN
cord-285806-363ivs67	26	14	necrosis	necrosis	NN
cord-285806-363ivs67	26	15	factor	factor	NN
cord-285806-363ivs67	26	16	(	(	-LRB-
cord-285806-363ivs67	26	17	TNF	TNF	NNP
cord-285806-363ivs67	26	18	-	-	HYPH
cord-285806-363ivs67	26	19	alfa	alfa	NNP
cord-285806-363ivs67	26	20	)	)	-RRB-
cord-285806-363ivs67	26	21	,	,	,
cord-285806-363ivs67	26	22	but	but	CC
cord-285806-363ivs67	26	23	many	many	JJ
cord-285806-363ivs67	26	24	other	other	JJ
cord-285806-363ivs67	26	25	factors	factor	NNS
cord-285806-363ivs67	26	26	can	can	MD
cord-285806-363ivs67	26	27	contribute	contribute	VB
cord-285806-363ivs67	26	28	to	to	IN
cord-285806-363ivs67	26	29	its	-PRON-	PRP$
cord-285806-363ivs67	26	30	secretion	secretion	NN
cord-285806-363ivs67	26	31	such	such	JJ
cord-285806-363ivs67	26	32	as	as	IN
cord-285806-363ivs67	26	33	Toll	toll	NN
cord-285806-363ivs67	26	34	-	-	HYPH
cord-285806-363ivs67	26	35	like	like	JJ
cord-285806-363ivs67	26	36	receptors	receptor	NNS
cord-285806-363ivs67	26	37	(	(	-LRB-
cord-285806-363ivs67	26	38	TLRs	TLRs	NNP
cord-285806-363ivs67	26	39	)	)	-RRB-
cord-285806-363ivs67	26	40	,	,	,
cord-285806-363ivs67	26	41	prostaglandins	prostaglandin	NNS
cord-285806-363ivs67	26	42	,	,	,
cord-285806-363ivs67	26	43	adipokines	adipokine	NNS
cord-285806-363ivs67	26	44	,	,	,
cord-285806-363ivs67	26	45	stress	stress	NN
cord-285806-363ivs67	26	46	response	response	NN
cord-285806-363ivs67	26	47	and	and	CC
cord-285806-363ivs67	26	48	other	other	JJ
cord-285806-363ivs67	26	49	cytokines	cytokine	NNS
cord-285806-363ivs67	26	50	13	13	CD
cord-285806-363ivs67	26	51	.	.	.
cord-285806-363ivs67	27	1	In	in	IN
cord-285806-363ivs67	27	2	the	the	DT
cord-285806-363ivs67	27	3	early	early	JJ
cord-285806-363ivs67	27	4	stage	stage	NN
cord-285806-363ivs67	27	5	of	of	IN
cord-285806-363ivs67	27	6	the	the	DT
cord-285806-363ivs67	27	7	infectious	infectious	JJ
cord-285806-363ivs67	27	8	inflammation	inflammation	NN
cord-285806-363ivs67	27	9	,	,	,
cord-285806-363ivs67	27	10	IL-6	IL-6	NNP
cord-285806-363ivs67	27	11	is	be	VBZ
cord-285806-363ivs67	27	12	produced	produce	VBN
cord-285806-363ivs67	27	13	by	by	IN
cord-285806-363ivs67	27	14	monocytes	monocyte	NNS
cord-285806-363ivs67	27	15	and	and	CC
cord-285806-363ivs67	27	16	macrophages	macrophage	NNS
cord-285806-363ivs67	27	17	stimulated	stimulate	VBN
cord-285806-363ivs67	27	18	by	by	IN
cord-285806-363ivs67	27	19	the	the	DT
cord-285806-363ivs67	27	20	TLRs	TLRs	NNP
cord-285806-363ivs67	27	21	14	14	CD
cord-285806-363ivs67	27	22	.	.	.
cord-285806-363ivs67	28	1	IL-6	IL-6	NNP
cord-285806-363ivs67	28	2	plays	play	VBZ
cord-285806-363ivs67	28	3	a	a	DT
cord-285806-363ivs67	28	4	crucial	crucial	JJ
cord-285806-363ivs67	28	5	role	role	NN
cord-285806-363ivs67	28	6	in	in	IN
cord-285806-363ivs67	28	7	infectious	infectious	JJ
cord-285806-363ivs67	28	8	diseases	disease	NNS
cord-285806-363ivs67	28	9	such	such	JJ
cord-285806-363ivs67	28	10	as	as	IN
cord-285806-363ivs67	28	11	influenza	influenza	NN
cord-285806-363ivs67	28	12	where	where	WRB
cord-285806-363ivs67	28	13	it	-PRON-	PRP
cord-285806-363ivs67	28	14	has	have	VBZ
cord-285806-363ivs67	28	15	been	be	VBN
cord-285806-363ivs67	28	16	shown	show	VBN
cord-285806-363ivs67	28	17	how	how	WRB
cord-285806-363ivs67	28	18	in	in	IN
cord-285806-363ivs67	28	19	a	a	DT
cord-285806-363ivs67	28	20	IL6	il6	NN
cord-285806-363ivs67	28	21	-/mice	-/mice	NN
cord-285806-363ivs67	28	22	influenza	influenza	JJ
cord-285806-363ivs67	28	23	specific	specific	JJ
cord-285806-363ivs67	28	24	CD4	CD4	NNP
cord-285806-363ivs67	28	25	+	+	CC
cord-285806-363ivs67	28	26	T	T	NNP
cord-285806-363ivs67	28	27	cell	cell	NN
cord-285806-363ivs67	28	28	response	response	NN
cord-285806-363ivs67	28	29	is	be	VBZ
cord-285806-363ivs67	28	30	impaired	impair	VBN
cord-285806-363ivs67	28	31	15	15	CD
cord-285806-363ivs67	28	32	.	.	.
cord-285806-363ivs67	29	1	Loss	loss	NN
cord-285806-363ivs67	29	2	of	of	IN
cord-285806-363ivs67	29	3	IL-6	IL-6	NNP
cord-285806-363ivs67	29	4	results	result	NNS
cord-285806-363ivs67	29	5	also	also	RB
cord-285806-363ivs67	29	6	in	in	IN
cord-285806-363ivs67	29	7	persistence	persistence	NN
cord-285806-363ivs67	29	8	of	of	IN
cord-285806-363ivs67	29	9	the	the	DT
cord-285806-363ivs67	29	10	influenza	influenza	NN
cord-285806-363ivs67	29	11	virus	virus	NN
cord-285806-363ivs67	29	12	in	in	IN
cord-285806-363ivs67	29	13	the	the	DT
cord-285806-363ivs67	29	14	lung	lung	NN
cord-285806-363ivs67	29	15	leading	lead	VBG
cord-285806-363ivs67	29	16	to	to	IN
cord-285806-363ivs67	29	17	extreme	extreme	JJ
cord-285806-363ivs67	29	18	lung	lung	NN
cord-285806-363ivs67	29	19	damage	damage	NN
cord-285806-363ivs67	29	20	and	and	CC
cord-285806-363ivs67	29	21	death	death	NN
cord-285806-363ivs67	29	22	16	16	CD
cord-285806-363ivs67	29	23	.	.	.
cord-285806-363ivs67	30	1	This	this	DT
cord-285806-363ivs67	30	2	shows	show	VBZ
cord-285806-363ivs67	30	3	how	how	WRB
cord-285806-363ivs67	30	4	IL-6	IL-6	NNP
cord-285806-363ivs67	30	5	limits	limit	VBZ
cord-285806-363ivs67	30	6	influenza	influenza	NN
cord-285806-363ivs67	30	7	-	-	HYPH
cord-285806-363ivs67	30	8	induced	induce	VBN
cord-285806-363ivs67	30	9	inflammation	inflammation	NN
cord-285806-363ivs67	30	10	and	and	CC
cord-285806-363ivs67	30	11	protects	protect	VBZ
cord-285806-363ivs67	30	12	against	against	IN
cord-285806-363ivs67	30	13	lung	lung	NN
cord-285806-363ivs67	30	14	damage	damage	NN
cord-285806-363ivs67	30	15	17	17	CD
cord-285806-363ivs67	30	16	by	by	IN
cord-285806-363ivs67	30	17	promoting	promote	VBG
cord-285806-363ivs67	30	18	neutrophil	neutrophil	NN
cord-285806-363ivs67	30	19	survival	survival	NN
cord-285806-363ivs67	30	20	in	in	IN
cord-285806-363ivs67	30	21	the	the	DT
cord-285806-363ivs67	30	22	lung	lung	NN
cord-285806-363ivs67	30	23	16	16	CD
cord-285806-363ivs67	30	24	.	.	.
cord-285806-363ivs67	31	1	IL-6	IL-6	NNP
cord-285806-363ivs67	32	1	crucial	crucial	JJ
cord-285806-363ivs67	32	2	role	role	NN
cord-285806-363ivs67	32	3	is	be	VBZ
cord-285806-363ivs67	32	4	not	not	RB
cord-285806-363ivs67	32	5	limited	limit	VBN
cord-285806-363ivs67	32	6	to	to	IN
cord-285806-363ivs67	32	7	influenza	influenza	NN
cord-285806-363ivs67	32	8	but	but	CC
cord-285806-363ivs67	32	9	also	also	RB
cord-285806-363ivs67	32	10	in	in	IN
cord-285806-363ivs67	32	11	other	other	JJ
cord-285806-363ivs67	32	12	infections	infection	NNS
cord-285806-363ivs67	32	13	such	such	JJ
cord-285806-363ivs67	32	14	as	as	IN
cord-285806-363ivs67	32	15	Herpes	Herpes	NNP
cord-285806-363ivs67	32	16	Simplex	Simplex	NNP
cord-285806-363ivs67	32	17	Virus-1	Virus-1	NNP
cord-285806-363ivs67	32	18	(	(	-LRB-
cord-285806-363ivs67	32	19	HSV-1	hsv-1	NN
cord-285806-363ivs67	32	20	)	)	-RRB-
cord-285806-363ivs67	32	21	infection	infection	NN
cord-285806-363ivs67	32	22	where	where	WRB
cord-285806-363ivs67	32	23	IL-6	IL-6	NNP
cord-285806-363ivs67	32	24	deficient	deficient	JJ
cord-285806-363ivs67	32	25	mice	mouse	NNS
cord-285806-363ivs67	32	26	shows	show	VBZ
cord-285806-363ivs67	32	27	an	an	DT
cord-285806-363ivs67	32	28	increase	increase	NN
cord-285806-363ivs67	32	29	in	in	IN
cord-285806-363ivs67	32	30	infection	infection	NN
cord-285806-363ivs67	32	31	susceptibility	susceptibility	NN
cord-285806-363ivs67	32	32	18	18	CD
cord-285806-363ivs67	32	33	.	.	.
cord-285806-363ivs67	33	1	In	in	IN
cord-285806-363ivs67	33	2	other	other	JJ
cord-285806-363ivs67	33	3	scenarios	scenario	NNS
cord-285806-363ivs67	33	4	,	,	,
cord-285806-363ivs67	33	5	such	such	JJ
cord-285806-363ivs67	33	6	as	as	IN
cord-285806-363ivs67	33	7	Respiratory	respiratory	JJ
cord-285806-363ivs67	33	8	Syncytial	Syncytial	NNP
cord-285806-363ivs67	33	9	Virus	virus	NN
cord-285806-363ivs67	33	10	(	(	-LRB-
cord-285806-363ivs67	33	11	RSV	RSV	NNP
cord-285806-363ivs67	33	12	)	)	-RRB-
cord-285806-363ivs67	33	13	infections	infection	NNS
cord-285806-363ivs67	33	14	in	in	IN
cord-285806-363ivs67	33	15	mice	mouse	NNS
cord-285806-363ivs67	33	16	,	,	,
cord-285806-363ivs67	33	17	early	early	JJ
cord-285806-363ivs67	33	18	depletion	depletion	NN
cord-285806-363ivs67	33	19	of	of	IN
cord-285806-363ivs67	33	20	IL-6	IL-6	NNP
cord-285806-363ivs67	33	21	,	,	,
cord-285806-363ivs67	33	22	but	but	CC
cord-285806-363ivs67	33	23	not	not	RB
cord-285806-363ivs67	33	24	late	late	RB
cord-285806-363ivs67	33	25	,	,	,
cord-285806-363ivs67	33	26	resulted	result	VBD
cord-285806-363ivs67	33	27	in	in	IN
cord-285806-363ivs67	33	28	significant	significant	JJ
cord-285806-363ivs67	33	29	increase	increase	NN
cord-285806-363ivs67	33	30	of	of	IN
cord-285806-363ivs67	33	31	the	the	DT
cord-285806-363ivs67	33	32	disease	disease	NN
cord-285806-363ivs67	33	33	with	with	IN
cord-285806-363ivs67	33	34	an	an	DT
cord-285806-363ivs67	33	35	associated	associate	VBN
cord-285806-363ivs67	33	36	influx	influx	NN
cord-285806-363ivs67	33	37	of	of	IN
cord-285806-363ivs67	33	38	cytotoxic	cytotoxic	JJ
cord-285806-363ivs67	33	39	CD8	CD8	NNP
cord-285806-363ivs67	33	40	+	+	CC
cord-285806-363ivs67	33	41	T	T	NNP
cord-285806-363ivs67	33	42	cells	cell	NNS
cord-285806-363ivs67	33	43	19	19	CD
cord-285806-363ivs67	33	44	.	.	.
cord-285806-363ivs67	34	1	High	high	JJ
cord-285806-363ivs67	34	2	levels	level	NNS
cord-285806-363ivs67	34	3	of	of	IN
cord-285806-363ivs67	34	4	interleukin	interleukin	NN
cord-285806-363ivs67	34	5	6	6	CD
cord-285806-363ivs67	34	6	(	(	-LRB-
cord-285806-363ivs67	34	7	IL-6	IL-6	NNP
cord-285806-363ivs67	34	8	)	)	-RRB-
cord-285806-363ivs67	34	9	and	and	CC
cord-285806-363ivs67	34	10	Interleukin	Interleukin	NNP
cord-285806-363ivs67	34	11	8	8	CD
cord-285806-363ivs67	35	1	(	(	-LRB-
cord-285806-363ivs67	35	2	IL	IL	NNP
cord-285806-363ivs67	35	3	8)	8)	NNP
cord-285806-363ivs67	35	4	were	be	VBD
cord-285806-363ivs67	35	5	found	find	VBN
cord-285806-363ivs67	35	6	in	in	IN
cord-285806-363ivs67	35	7	the	the	DT
cord-285806-363ivs67	35	8	acute	acute	JJ
cord-285806-363ivs67	35	9	stage	stage	NN
cord-285806-363ivs67	35	10	associated	associate	VBN
cord-285806-363ivs67	35	11	with	with	IN
cord-285806-363ivs67	35	12	lung	lung	NN
cord-285806-363ivs67	35	13	lesions	lesion	NNS
cord-285806-363ivs67	35	14	in	in	IN
cord-285806-363ivs67	35	15	SARS	SARS	NNP
cord-285806-363ivs67	35	16	-	-	HYPH
cord-285806-363ivs67	35	17	CoV-1	CoV-1	NNP
cord-285806-363ivs67	35	18	patients	patient	NNS
cord-285806-363ivs67	35	19	.	.	.
cord-285806-363ivs67	36	1	Especially	especially	RB
cord-285806-363ivs67	36	2	IL-6	IL-6	NNP
cord-285806-363ivs67	36	3	can	can	MD
cord-285806-363ivs67	36	4	induce	induce	VB
cord-285806-363ivs67	36	5	the	the	DT
cord-285806-363ivs67	36	6	hyper	hyper	JJ
cord-285806-363ivs67	36	7	-	-	JJ
cord-285806-363ivs67	36	8	innate	innate	JJ
cord-285806-363ivs67	36	9	inflammatory	inflammatory	JJ
cord-285806-363ivs67	36	10	response	response	NN
cord-285806-363ivs67	36	11	due	due	IN
cord-285806-363ivs67	36	12	to	to	IN
cord-285806-363ivs67	36	13	the	the	DT
cord-285806-363ivs67	36	14	SARS	SARS	NNP
cord-285806-363ivs67	36	15	-	-	HYPH
cord-285806-363ivs67	36	16	CoV-1	CoV-1	NNP
cord-285806-363ivs67	36	17	invasion	invasion	NN
cord-285806-363ivs67	36	18	of	of	IN
cord-285806-363ivs67	36	19	the	the	DT
cord-285806-363ivs67	36	20	respiratory	respiratory	JJ
cord-285806-363ivs67	36	21	tract	tract	NN
cord-285806-363ivs67	36	22	20	20	CD
cord-285806-363ivs67	36	23	.	.	.
cord-285806-363ivs67	37	1	Interestingly	interestingly	RB
cord-285806-363ivs67	37	2	,	,	,
cord-285806-363ivs67	37	3	in	in	IN
cord-285806-363ivs67	37	4	human	human	JJ
cord-285806-363ivs67	37	5	epithelial	epithelial	JJ
cord-285806-363ivs67	37	6	cells	cell	NNS
cord-285806-363ivs67	37	7	,	,	,
cord-285806-363ivs67	37	8	SARS	SARS	NNP
cord-285806-363ivs67	37	9	-	-	HYPH
cord-285806-363ivs67	37	10	CoV-1	CoV-1	NNP
cord-285806-363ivs67	37	11	was	be	VBD
cord-285806-363ivs67	37	12	able	able	JJ
cord-285806-363ivs67	37	13	to	to	TO
cord-285806-363ivs67	37	14	induce	induce	VB
cord-285806-363ivs67	37	15	greater	great	JJR
cord-285806-363ivs67	37	16	IL-6	IL-6	NNP
cord-285806-363ivs67	37	17	when	when	WRB
cord-285806-363ivs67	37	18	compared	compare	VBN
cord-285806-363ivs67	37	19	to	to	IN
cord-285806-363ivs67	37	20	influenza	influenza	NN
cord-285806-363ivs67	37	21	A	a	DT
cord-285806-363ivs67	37	22	virus	virus	NN
cord-285806-363ivs67	37	23	21	21	CD
cord-285806-363ivs67	37	24	.	.	.
cord-285806-363ivs67	38	1	Although	although	IN
cord-285806-363ivs67	38	2	in	in	IN
cord-285806-363ivs67	38	3	some	some	DT
cord-285806-363ivs67	38	4	murine	murine	JJ
cord-285806-363ivs67	38	5	viral	viral	JJ
cord-285806-363ivs67	38	6	infections	infection	NNS
cord-285806-363ivs67	38	7	IL-6	IL-6	NNP
cord-285806-363ivs67	38	8	plays	play	VBZ
cord-285806-363ivs67	38	9	a	a	DT
cord-285806-363ivs67	38	10	protective	protective	JJ
cord-285806-363ivs67	38	11	and	and	CC
cord-285806-363ivs67	38	12	essential	essential	JJ
cord-285806-363ivs67	38	13	role	role	NN
cord-285806-363ivs67	38	14	in	in	IN
cord-285806-363ivs67	38	15	the	the	DT
cord-285806-363ivs67	38	16	resolution	resolution	NN
cord-285806-363ivs67	38	17	process	process	NN
cord-285806-363ivs67	38	18	,	,	,
cord-285806-363ivs67	38	19	in	in	IN
cord-285806-363ivs67	38	20	others	other	NNS
cord-285806-363ivs67	38	21	like	like	IN
cord-285806-363ivs67	38	22	in	in	IN
cord-285806-363ivs67	38	23	SARS	SARS	NNP
cord-285806-363ivs67	38	24	-	-	HYPH
cord-285806-363ivs67	38	25	CoV-1	CoV-1	NNP
cord-285806-363ivs67	38	26	high	high	JJ
cord-285806-363ivs67	38	27	levels	level	NNS
cord-285806-363ivs67	38	28	of	of	IN
cord-285806-363ivs67	38	29	IL-6	IL-6	NNP
cord-285806-363ivs67	38	30	were	be	VBD
cord-285806-363ivs67	38	31	associated	associate	VBN
cord-285806-363ivs67	38	32	with	with	IN
cord-285806-363ivs67	38	33	severe	severe	JJ
cord-285806-363ivs67	38	34	inflammation	inflammation	NN
cord-285806-363ivs67	38	35	and	and	CC
cord-285806-363ivs67	38	36	correlated	correlate	VBN
cord-285806-363ivs67	38	37	with	with	IN
cord-285806-363ivs67	38	38	mortality	mortality	NN
cord-285806-363ivs67	38	39	in	in	IN
cord-285806-363ivs67	38	40	the	the	DT
cord-285806-363ivs67	38	41	mice	mice	NN
cord-285806-363ivs67	38	42	22	22	CD
cord-285806-363ivs67	38	43	,	,	,
cord-285806-363ivs67	38	44	23	23	CD
cord-285806-363ivs67	38	45	.	.	.
cord-285806-363ivs67	39	1	This	this	DT
cord-285806-363ivs67	39	2	happens	happen	VBZ
cord-285806-363ivs67	39	3	also	also	RB
cord-285806-363ivs67	39	4	with	with	IN
cord-285806-363ivs67	39	5	SARS	SARS	NNP
cord-285806-363ivs67	39	6	-	-	HYPH
cord-285806-363ivs67	39	7	CoV-2	CoV-2	NNP
cord-285806-363ivs67	39	8	in	in	IN
cord-285806-363ivs67	39	9	COVID-19	covid-19	CD
cord-285806-363ivs67	39	10	patients	patient	NNS
cord-285806-363ivs67	39	11	:	:	:
cord-285806-363ivs67	39	12	some	some	DT
cord-285806-363ivs67	39	13	retrospective	retrospective	JJ
cord-285806-363ivs67	39	14	and	and	CC
cord-285806-363ivs67	39	15	meta	meta	JJ
cord-285806-363ivs67	39	16	-	-	HYPH
cord-285806-363ivs67	39	17	analysis	analysis	NN
cord-285806-363ivs67	39	18	studies	study	NNS
cord-285806-363ivs67	39	19	show	show	VBP
cord-285806-363ivs67	39	20	how	how	WRB
cord-285806-363ivs67	39	21	elevated	elevate	VBN
cord-285806-363ivs67	39	22	IL-6	IL-6	NNP
cord-285806-363ivs67	39	23	and	and	CC
cord-285806-363ivs67	39	24	C	C	NNP
cord-285806-363ivs67	39	25	-	-	HYPH
cord-285806-363ivs67	39	26	reactive	reactive	JJ
cord-285806-363ivs67	39	27	protein	protein	NN
cord-285806-363ivs67	39	28	(	(	-LRB-
cord-285806-363ivs67	39	29	CRP	CRP	NNP
cord-285806-363ivs67	39	30	)	)	-RRB-
cord-285806-363ivs67	39	31	correlate	correlate	VBP
cord-285806-363ivs67	39	32	with	with	IN
cord-285806-363ivs67	39	33	mortality	mortality	NN
cord-285806-363ivs67	39	34	and	and	CC
cord-285806-363ivs67	39	35	severe	severe	JJ
cord-285806-363ivs67	39	36	disease	disease	NN
cord-285806-363ivs67	39	37	in	in	IN
cord-285806-363ivs67	39	38	comparison	comparison	NN
cord-285806-363ivs67	39	39	to	to	IN
cord-285806-363ivs67	39	40	moderate	moderate	JJ
cord-285806-363ivs67	39	41	disease	disease	NN
cord-285806-363ivs67	39	42	[	[	-LRB-
cord-285806-363ivs67	39	43	24	24	CD
cord-285806-363ivs67	39	44	]	]	-RRB-
cord-285806-363ivs67	40	1	[	[	-LRB-
cord-285806-363ivs67	40	2	25	25	CD
cord-285806-363ivs67	40	3	]	]	-RRB-
cord-285806-363ivs67	40	4	[	[	-LRB-
cord-285806-363ivs67	40	5	26	26	CD
cord-285806-363ivs67	40	6	]	]	-RRB-
cord-285806-363ivs67	40	7	[	[	-LRB-
cord-285806-363ivs67	40	8	27	27	CD
cord-285806-363ivs67	40	9	]	]	-RRB-
cord-285806-363ivs67	40	10	.	.	.
cord-285806-363ivs67	41	1	More	More	JJR
cord-285806-363ivs67	41	2	evidence	evidence	NN
cord-285806-363ivs67	41	3	suggests	suggest	VBZ
cord-285806-363ivs67	41	4	that	that	IN
cord-285806-363ivs67	41	5	critically	critically	RB
cord-285806-363ivs67	41	6	ill	ill	VBP
cord-285806-363ivs67	41	7	patients	patient	NNS
cord-285806-363ivs67	41	8	with	with	IN
cord-285806-363ivs67	41	9	severe	severe	JJ
cord-285806-363ivs67	41	10	respiratory	respiratory	JJ
cord-285806-363ivs67	41	11	failure	failure	NN
cord-285806-363ivs67	41	12	and	and	CC
cord-285806-363ivs67	41	13	SARS	SARS	NNP
cord-285806-363ivs67	41	14	-	-	HYPH
cord-285806-363ivs67	41	15	CoV-2	CoV-2	NNP
cord-285806-363ivs67	41	16	have	have	VBP
cord-285806-363ivs67	41	17	either	either	DT
cord-285806-363ivs67	41	18	immune	immune	JJ
cord-285806-363ivs67	41	19	dysregulation	dysregulation	NN
cord-285806-363ivs67	41	20	or	or	CC
cord-285806-363ivs67	41	21	macrophage	macrophage	NN
cord-285806-363ivs67	41	22	-	-	HYPH
cord-285806-363ivs67	41	23	activation	activation	NN
cord-285806-363ivs67	41	24	syndrome	syndrome	NN
cord-285806-363ivs67	41	25	,	,	,
cord-285806-363ivs67	41	26	both	both	DT
cord-285806-363ivs67	41	27	of	of	IN
cord-285806-363ivs67	41	28	which	which	WDT
cord-285806-363ivs67	41	29	are	be	VBP
cord-285806-363ivs67	41	30	characterized	characterize	VBN
cord-285806-363ivs67	41	31	by	by	IN
cord-285806-363ivs67	41	32	pro	pro	JJ
cord-285806-363ivs67	41	33	-	-	JJ
cord-285806-363ivs67	41	34	inflammatory	inflammatory	JJ
cord-285806-363ivs67	41	35	cytokines	cytokine	NNS
cord-285806-363ivs67	41	36	.	.	.
cord-285806-363ivs67	42	1	The	the	DT
cord-285806-363ivs67	42	2	immune	immune	JJ
cord-285806-363ivs67	42	3	dysregulation	dysregulation	NN
cord-285806-363ivs67	42	4	,	,	,
cord-285806-363ivs67	42	5	in	in	IN
cord-285806-363ivs67	42	6	particular	particular	JJ
cord-285806-363ivs67	42	7	,	,	,
cord-285806-363ivs67	42	8	is	be	VBZ
cord-285806-363ivs67	42	9	driven	drive	VBN
cord-285806-363ivs67	42	10	by	by	IN
cord-285806-363ivs67	42	11	the	the	DT
cord-285806-363ivs67	42	12	Interleukin-6	Interleukin-6	NNP
cord-285806-363ivs67	42	13	(	(	-LRB-
cord-285806-363ivs67	42	14	IL-	IL-	NNP
cord-285806-363ivs67	42	15	6	6	CD
cord-285806-363ivs67	42	16	)	)	-RRB-
cord-285806-363ivs67	42	17	and	and	CC
cord-285806-363ivs67	42	18	not	not	RB
cord-285806-363ivs67	42	19	by	by	IN
cord-285806-363ivs67	42	20	Interleukin-1beta	interleukin-1beta	NN
cord-285806-363ivs67	42	21	(	(	-LRB-
cord-285806-363ivs67	42	22	IL-1beta	il-1beta	NN
cord-285806-363ivs67	42	23	)	)	-RRB-
cord-285806-363ivs67	42	24	27	27	CD
cord-285806-363ivs67	42	25	.	.	.
cord-285806-363ivs67	43	1	Two	two	CD
cord-285806-363ivs67	43	2	key	key	JJ
cord-285806-363ivs67	43	3	features	feature	NNS
cord-285806-363ivs67	43	4	of	of	IN
cord-285806-363ivs67	43	5	this	this	DT
cord-285806-363ivs67	43	6	immune	immune	JJ
cord-285806-363ivs67	43	7	dysregulation	dysregulation	NN
cord-285806-363ivs67	43	8	are	be	VBP
cord-285806-363ivs67	43	9	:	:	:
cord-285806-363ivs67	43	10	over	over	IN
cord-285806-363ivs67	43	11	-	-	HYPH
cord-285806-363ivs67	43	12	production	production	NN
cord-285806-363ivs67	43	13	of	of	IN
cord-285806-363ivs67	43	14	pro	pro	JJ
cord-285806-363ivs67	43	15	-	-	JJ
cord-285806-363ivs67	43	16	inflammatory	inflammatory	JJ
cord-285806-363ivs67	43	17	cytokines	cytokine	NNS
cord-285806-363ivs67	43	18	by	by	IN
cord-285806-363ivs67	43	19	monocytes	monocyte	NNS
cord-285806-363ivs67	43	20	and	and	CC
cord-285806-363ivs67	43	21	lymphocyte	lymphocyte	NN
cord-285806-363ivs67	43	22	dysregulation	dysregulation	NN
cord-285806-363ivs67	43	23	with	with	IN
cord-285806-363ivs67	43	24	CD4	CD4	NNP
cord-285806-363ivs67	43	25	lymphopenia	lymphopenia	NNP
cord-285806-363ivs67	43	26	27	27	CD
cord-285806-363ivs67	43	27	.	.	.
cord-285806-363ivs67	44	1	A	a	DT
cord-285806-363ivs67	44	2	relevant	relevant	JJ
cord-285806-363ivs67	44	3	study	study	NN
cord-285806-363ivs67	44	4	shows	show	VBZ
cord-285806-363ivs67	44	5	how	how	WRB
cord-285806-363ivs67	44	6	IL-6	IL-6	NNP
cord-285806-363ivs67	44	7	plays	play	VBZ
cord-285806-363ivs67	44	8	a	a	DT
cord-285806-363ivs67	44	9	major	major	JJ
cord-285806-363ivs67	44	10	role	role	NN
cord-285806-363ivs67	44	11	in	in	IN
cord-285806-363ivs67	44	12	acute	acute	JJ
cord-285806-363ivs67	44	13	lung	lung	NN
cord-285806-363ivs67	44	14	injury	injury	NN
cord-285806-363ivs67	44	15	(	(	-LRB-
cord-285806-363ivs67	44	16	ALI	ALI	NNP
cord-285806-363ivs67	44	17	)	)	-RRB-
cord-285806-363ivs67	44	18	,	,	,
cord-285806-363ivs67	44	19	proof	proof	NN
cord-285806-363ivs67	44	20	of	of	IN
cord-285806-363ivs67	44	21	that	that	DT
cord-285806-363ivs67	44	22	was	be	VBD
cord-285806-363ivs67	44	23	obtained	obtain	VBN
cord-285806-363ivs67	44	24	in	in	IN
cord-285806-363ivs67	44	25	a	a	DT
cord-285806-363ivs67	44	26	murine	murine	JJ
cord-285806-363ivs67	44	27	model	model	NN
cord-285806-363ivs67	44	28	,	,	,
cord-285806-363ivs67	44	29	where	where	WRB
cord-285806-363ivs67	44	30	loss	loss	NN
cord-285806-363ivs67	44	31	of	of	IN
cord-285806-363ivs67	44	32	IL-6	IL-6	NNP
cord-285806-363ivs67	44	33	showed	show	VBD
cord-285806-363ivs67	44	34	to	to	TO
cord-285806-363ivs67	44	35	alleviate	alleviate	VB
cord-285806-363ivs67	44	36	the	the	DT
cord-285806-363ivs67	44	37	severity	severity	NN
cord-285806-363ivs67	44	38	of	of	IN
cord-285806-363ivs67	44	39	ALI	ALI	NNP
cord-285806-363ivs67	44	40	in	in	IN
cord-285806-363ivs67	44	41	response	response	NN
cord-285806-363ivs67	44	42	to	to	IN
cord-285806-363ivs67	44	43	acid	acid	JJ
cord-285806-363ivs67	44	44	respiration	respiration	NN
cord-285806-363ivs67	44	45	.	.	.
cord-285806-363ivs67	45	1	Moreover	moreover	RB
cord-285806-363ivs67	45	2	,	,	,
cord-285806-363ivs67	45	3	it	-PRON-	PRP
cord-285806-363ivs67	45	4	was	be	VBD
cord-285806-363ivs67	45	5	shown	show	VBN
cord-285806-363ivs67	45	6	how	how	WRB
cord-285806-363ivs67	45	7	SARS	SARS	NNP
cord-285806-363ivs67	45	8	-	-	HYPH
cord-285806-363ivs67	45	9	CoV-1	CoV-1	NNP
cord-285806-363ivs67	45	10	has	have	VBZ
cord-285806-363ivs67	45	11	the	the	DT
cord-285806-363ivs67	45	12	ability	ability	NN
cord-285806-363ivs67	45	13	of	of	IN
cord-285806-363ivs67	45	14	inducing	induce	VBG
cord-285806-363ivs67	45	15	production	production	NN
cord-285806-363ivs67	45	16	of	of	IN
cord-285806-363ivs67	45	17	compounds	compound	NNS
cord-285806-363ivs67	45	18	like	like	IN
cord-285806-363ivs67	45	19	oxidized	oxidized	JJ
cord-285806-363ivs67	45	20	phospholipid	phospholipid	NN
cord-285806-363ivs67	45	21	(	(	-LRB-
cord-285806-363ivs67	45	22	OxPL	OxPL	NNP
cord-285806-363ivs67	45	23	)	)	-RRB-
cord-285806-363ivs67	45	24	both	both	DT
cord-285806-363ivs67	45	25	in	in	IN
cord-285806-363ivs67	45	26	humans	human	NNS
cord-285806-363ivs67	45	27	and	and	CC
cord-285806-363ivs67	45	28	animals	animal	NNS
cord-285806-363ivs67	45	29	.	.	.
cord-285806-363ivs67	46	1	OxPLs	oxpls	NN
cord-285806-363ivs67	46	2	in	in	IN
cord-285806-363ivs67	46	3	turn	turn	NN
cord-285806-363ivs67	46	4	induce	induce	VB
cord-285806-363ivs67	46	5	cytokine	cytokine	NN
cord-285806-363ivs67	46	6	production	production	NN
cord-285806-363ivs67	46	7	and	and	CC
cord-285806-363ivs67	46	8	acute	acute	JJ
cord-285806-363ivs67	46	9	lung	lung	NN
cord-285806-363ivs67	46	10	injury	injury	NN
cord-285806-363ivs67	46	11	via	via	IN
cord-285806-363ivs67	46	12	Toll	toll	NN
cord-285806-363ivs67	47	1	Like	like	IN
cord-285806-363ivs67	47	2	Receptor	receptor	NN
cord-285806-363ivs67	47	3	4	4	CD
cord-285806-363ivs67	48	1	(	(	-LRB-
cord-285806-363ivs67	48	2	TLR4	TLR4	NNP
cord-285806-363ivs67	48	3	)	)	-RRB-
cord-285806-363ivs67	48	4	28	28	CD
cord-285806-363ivs67	48	5	.	.	.
cord-285806-363ivs67	49	1	This	this	DT
cord-285806-363ivs67	49	2	is	be	VBZ
cord-285806-363ivs67	49	3	evidence	evidence	NN
cord-285806-363ivs67	49	4	of	of	IN
cord-285806-363ivs67	49	5	SARS	SARS	NNP
cord-285806-363ivs67	49	6	-	-	HYPH
cord-285806-363ivs67	49	7	CoV-1	CoV-1	NNP
cord-285806-363ivs67	49	8	ability	ability	NN
cord-285806-363ivs67	49	9	to	to	TO
cord-285806-363ivs67	49	10	indirectly	indirectly	RB
cord-285806-363ivs67	49	11	induce	induce	VB
cord-285806-363ivs67	49	12	acute	acute	JJ
cord-285806-363ivs67	49	13	lung	lung	NN
cord-285806-363ivs67	49	14	injury	injury	NN
cord-285806-363ivs67	49	15	and	and	CC
cord-285806-363ivs67	49	16	cytokine	cytokine	NN
cord-285806-363ivs67	49	17	production	production	NN
cord-285806-363ivs67	49	18	,	,	,
cord-285806-363ivs67	49	19	like	like	IN
cord-285806-363ivs67	49	20	that	that	DT
cord-285806-363ivs67	49	21	of	of	IN
cord-285806-363ivs67	49	22	IL-6	IL-6	NNP
cord-285806-363ivs67	49	23	28	28	CD
cord-285806-363ivs67	49	24	,	,	,
cord-285806-363ivs67	49	25	29	29	CD
cord-285806-363ivs67	49	26	.	.	.
cord-285806-363ivs67	50	1	TLR4	TLR4	NNP
cord-285806-363ivs67	50	2	is	be	VBZ
cord-285806-363ivs67	50	3	a	a	DT
cord-285806-363ivs67	50	4	transmembrane	transmembrane	NN
cord-285806-363ivs67	50	5	protein	protein	NN
cord-285806-363ivs67	50	6	that	that	WDT
cord-285806-363ivs67	50	7	belongs	belong	VBZ
cord-285806-363ivs67	50	8	to	to	IN
cord-285806-363ivs67	50	9	the	the	DT
cord-285806-363ivs67	50	10	pattern	pattern	NN
cord-285806-363ivs67	50	11	recognition	recognition	NN
cord-285806-363ivs67	50	12	receptor	receptor	NN
cord-285806-363ivs67	50	13	family	family	NN
cord-285806-363ivs67	50	14	(	(	-LRB-
cord-285806-363ivs67	50	15	PRR	PRR	NNP
cord-285806-363ivs67	50	16	family	family	NN
cord-285806-363ivs67	50	17	)	)	-RRB-
cord-285806-363ivs67	50	18	,	,	,
cord-285806-363ivs67	50	19	it	-PRON-	PRP
cord-285806-363ivs67	50	20	recognizes	recognize	VBZ
cord-285806-363ivs67	50	21	molecules	molecule	NNS
cord-285806-363ivs67	50	22	like	like	IN
cord-285806-363ivs67	50	23	lipopolysaccharide	lipopolysaccharide	NN
cord-285806-363ivs67	50	24	(	(	-LRB-
cord-285806-363ivs67	50	25	LPS	LPS	NNP
cord-285806-363ivs67	50	26	)	)	-RRB-
cord-285806-363ivs67	51	1	thanks	thank	NNS
cord-285806-363ivs67	51	2	to	to	IN
cord-285806-363ivs67	51	3	an	an	DT
cord-285806-363ivs67	51	4	accessory	accessory	JJ
cord-285806-363ivs67	51	5	protein	protein	NN
cord-285806-363ivs67	51	6	known	know	VBN
cord-285806-363ivs67	51	7	as	as	IN
cord-285806-363ivs67	51	8	MD-2	MD-2	NNP
cord-285806-363ivs67	51	9	30	30	CD
cord-285806-363ivs67	51	10	.	.	.
cord-285806-363ivs67	52	1	TLRs	tlr	NNS
cord-285806-363ivs67	52	2	activate	activate	VBP
cord-285806-363ivs67	52	3	transcription	transcription	NN
cord-285806-363ivs67	52	4	factors	factor	NNS
cord-285806-363ivs67	52	5	like	like	IN
cord-285806-363ivs67	52	6	NFkB	nfkb	UH
cord-285806-363ivs67	52	7	,	,	,
cord-285806-363ivs67	52	8	AP-1	AP-1	NNP
cord-285806-363ivs67	52	9	and	and	CC
cord-285806-363ivs67	52	10	IRF	IRF	NNP
cord-285806-363ivs67	52	11	inducing	induce	VBG
cord-285806-363ivs67	52	12	proinflammatory	proinflammatory	JJ
cord-285806-363ivs67	52	13	cytokines	cytokine	NNS
cord-285806-363ivs67	52	14	expressions	expression	NNS
cord-285806-363ivs67	52	15	and	and	CC
cord-285806-363ivs67	53	1	Interferon	interferon	NN
cord-285806-363ivs67	53	2	1	1	CD
cord-285806-363ivs67	53	3	[	[	-LRB-
cord-285806-363ivs67	53	4	31	31	CD
cord-285806-363ivs67	53	5	]	]	-RRB-
cord-285806-363ivs67	53	6	[	[	-LRB-
cord-285806-363ivs67	53	7	32	32	CD
cord-285806-363ivs67	53	8	]	]	-RRB-
cord-285806-363ivs67	53	9	[	[	-LRB-
cord-285806-363ivs67	53	10	33	33	CD
cord-285806-363ivs67	53	11	]	]	-RRB-
cord-285806-363ivs67	53	12	.	.	.
cord-285806-363ivs67	54	1	TLR4	TLR4	NNP
cord-285806-363ivs67	54	2	is	be	VBZ
cord-285806-363ivs67	54	3	associated	associate	VBN
cord-285806-363ivs67	54	4	not	not	RB
cord-285806-363ivs67	54	5	only	only	RB
cord-285806-363ivs67	54	6	with	with	IN
cord-285806-363ivs67	54	7	infections	infection	NNS
cord-285806-363ivs67	54	8	but	but	CC
cord-285806-363ivs67	54	9	also	also	RB
cord-285806-363ivs67	54	10	with	with	IN
cord-285806-363ivs67	54	11	tissue	tissue	NN
cord-285806-363ivs67	54	12	damage	damage	NN
cord-285806-363ivs67	54	13	,	,	,
cord-285806-363ivs67	54	14	and	and	CC
cord-285806-363ivs67	54	15	this	this	DT
cord-285806-363ivs67	54	16	damage	damage	NN
cord-285806-363ivs67	54	17	-	-	HYPH
cord-285806-363ivs67	54	18	dependent	dependent	JJ
cord-285806-363ivs67	54	19	pathway	pathway	NN
cord-285806-363ivs67	54	20	may	may	MD
cord-285806-363ivs67	54	21	be	be	VB
cord-285806-363ivs67	54	22	amplified	amplify	VBN
cord-285806-363ivs67	54	23	in	in	IN
cord-285806-363ivs67	54	24	the	the	DT
cord-285806-363ivs67	54	25	acute	acute	JJ
cord-285806-363ivs67	54	26	stages	stage	NNS
cord-285806-363ivs67	54	27	of	of	IN
cord-285806-363ivs67	54	28	the	the	DT
cord-285806-363ivs67	54	29	infection	infection	NN
cord-285806-363ivs67	54	30	.	.	.
cord-285806-363ivs67	55	1	Of	of	IN
cord-285806-363ivs67	55	2	note	note	NN
cord-285806-363ivs67	55	3	,	,	,
cord-285806-363ivs67	55	4	TLR4-null	tlr4-null	JJ
cord-285806-363ivs67	55	5	mice	mouse	NNS
cord-285806-363ivs67	55	6	are	be	VBP
cord-285806-363ivs67	55	7	highly	highly	RB
cord-285806-363ivs67	55	8	resistant	resistant	JJ
cord-285806-363ivs67	55	9	to	to	IN
cord-285806-363ivs67	55	10	infection	infection	NN
cord-285806-363ivs67	55	11	by	by	IN
cord-285806-363ivs67	55	12	the	the	DT
cord-285806-363ivs67	55	13	mouse	mouse	NN
cord-285806-363ivs67	55	14	adapted	adapt	VBD
cord-285806-363ivs67	55	15	influenza	influenza	NN
cord-285806-363ivs67	55	16	A	a	DT
cord-285806-363ivs67	55	17	virus	virus	NN
cord-285806-363ivs67	55	18	34	34	CD
cord-285806-363ivs67	55	19	.	.	.
cord-285806-363ivs67	56	1	Protection	protection	NN
cord-285806-363ivs67	56	2	against	against	IN
cord-285806-363ivs67	56	3	influenza	influenza	NN
cord-285806-363ivs67	56	4	infections	infection	NNS
cord-285806-363ivs67	56	5	in	in	IN
cord-285806-363ivs67	56	6	mouse	mouse	NN
cord-285806-363ivs67	56	7	models	model	NNS
cord-285806-363ivs67	56	8	was	be	VBD
cord-285806-363ivs67	56	9	shown	show	VBN
cord-285806-363ivs67	56	10	to	to	TO
cord-285806-363ivs67	56	11	be	be	VB
cord-285806-363ivs67	56	12	achieved	achieve	VBN
cord-285806-363ivs67	56	13	by	by	IN
cord-285806-363ivs67	56	14	targeting	target	VBG
cord-285806-363ivs67	56	15	TLR4	TLR4	NNP
cord-285806-363ivs67	56	16	with	with	IN
cord-285806-363ivs67	56	17	antagonists	antagonist	NNS
cord-285806-363ivs67	56	18	or	or	CC
cord-285806-363ivs67	56	19	with	with	IN
cord-285806-363ivs67	56	20	specific	specific	JJ
cord-285806-363ivs67	56	21	anti	anti	JJ
cord-285806-363ivs67	56	22	-	-	JJ
cord-285806-363ivs67	56	23	receptor	receptor	JJ
cord-285806-363ivs67	56	24	antibodies	antibody	NNS
cord-285806-363ivs67	56	25	35	35	CD
cord-285806-363ivs67	56	26	.	.	.
cord-285806-363ivs67	57	1	Another	another	DT
cord-285806-363ivs67	57	2	option	option	NN
cord-285806-363ivs67	57	3	in	in	IN
cord-285806-363ivs67	57	4	targeting	target	VBG
cord-285806-363ivs67	57	5	host	host	JJ
cord-285806-363ivs67	57	6	inflammatory	inflammatory	JJ
cord-285806-363ivs67	57	7	response	response	NN
cord-285806-363ivs67	57	8	could	could	MD
cord-285806-363ivs67	57	9	then	then	RB
cord-285806-363ivs67	57	10	be	be	VB
cord-285806-363ivs67	57	11	targeting	target	VBG
cord-285806-363ivs67	57	12	the	the	DT
cord-285806-363ivs67	57	13	cellular	cellular	JJ
cord-285806-363ivs67	57	14	toll	toll	NN
cord-285806-363ivs67	57	15	-	-	HYPH
cord-285806-363ivs67	57	16	like	like	JJ
cord-285806-363ivs67	57	17	-	-	HYPH
cord-285806-363ivs67	57	18	receptor	receptor	NN
cord-285806-363ivs67	57	19	4	4	CD
cord-285806-363ivs67	57	20	(	(	-LRB-
cord-285806-363ivs67	57	21	TLR4	TLR4	NNP
cord-285806-363ivs67	57	22	)	)	-RRB-
cord-285806-363ivs67	57	23	.	.	.
cord-285806-363ivs67	58	1	Furthermore	furthermore	RB
cord-285806-363ivs67	58	2	,	,	,
cord-285806-363ivs67	58	3	TLR4	TLR4	NNP
cord-285806-363ivs67	58	4	seems	seem	VBZ
cord-285806-363ivs67	58	5	to	to	TO
cord-285806-363ivs67	58	6	regulate	regulate	VB
cord-285806-363ivs67	58	7	IL-6	IL-6	NNP
cord-285806-363ivs67	58	8	secretion	secretion	NN
cord-285806-363ivs67	58	9	through	through	IN
cord-285806-363ivs67	58	10	the	the	DT
cord-285806-363ivs67	58	11	NFkB	NFkB	NNP
cord-285806-363ivs67	58	12	pathway	pathway	NN
cord-285806-363ivs67	58	13	36	36	CD
cord-285806-363ivs67	58	14	.	.	.
cord-285806-363ivs67	59	1	This	this	DT
cord-285806-363ivs67	59	2	again	again	RB
cord-285806-363ivs67	59	3	points	point	VBZ
cord-285806-363ivs67	59	4	towards	towards	IN
cord-285806-363ivs67	59	5	excessive	excessive	JJ
cord-285806-363ivs67	59	6	activation	activation	NN
cord-285806-363ivs67	59	7	of	of	IN
cord-285806-363ivs67	59	8	the	the	DT
cord-285806-363ivs67	59	9	innate	innate	JJ
cord-285806-363ivs67	59	10	immune	immune	JJ
cord-285806-363ivs67	59	11	response	response	NN
cord-285806-363ivs67	59	12	.	.	.
cord-285806-363ivs67	60	1	Another	another	DT
cord-285806-363ivs67	60	2	proof	proof	NN
cord-285806-363ivs67	60	3	of	of	IN
cord-285806-363ivs67	60	4	that	that	DT
cord-285806-363ivs67	60	5	is	be	VBZ
cord-285806-363ivs67	60	6	the	the	DT
cord-285806-363ivs67	60	7	damage	damage	NN
cord-285806-363ivs67	60	8	shown	show	VBN
cord-285806-363ivs67	60	9	to	to	IN
cord-285806-363ivs67	60	10	the	the	DT
cord-285806-363ivs67	60	11	pulmonary	pulmonary	JJ
cord-285806-363ivs67	60	12	interstitial	interstitial	JJ
cord-285806-363ivs67	60	13	arteriolar	arteriolar	JJ
cord-285806-363ivs67	60	14	walls	wall	NNS
cord-285806-363ivs67	60	15	that	that	WDT
cord-285806-363ivs67	60	16	is	be	VBZ
cord-285806-363ivs67	60	17	more	more	RBR
cord-285806-363ivs67	60	18	associated	associate	VBN
cord-285806-363ivs67	60	19	with	with	IN
cord-285806-363ivs67	60	20	the	the	DT
cord-285806-363ivs67	60	21	inflammatory	inflammatory	JJ
cord-285806-363ivs67	60	22	response	response	NN
cord-285806-363ivs67	60	23	rather	rather	RB
cord-285806-363ivs67	60	24	than	than	IN
cord-285806-363ivs67	60	25	the	the	DT
cord-285806-363ivs67	60	26	pathogenic	pathogenic	JJ
cord-285806-363ivs67	60	27	effect	effect	NN
cord-285806-363ivs67	60	28	of	of	IN
cord-285806-363ivs67	60	29	coronaviruses	coronaviruse	NNS
cord-285806-363ivs67	60	30	37	37	CD
cord-285806-363ivs67	60	31	.	.	.
cord-285806-363ivs67	61	1	An	an	DT
cord-285806-363ivs67	61	2	interesting	interesting	JJ
cord-285806-363ivs67	61	3	fact	fact	NN
cord-285806-363ivs67	61	4	is	be	VBZ
cord-285806-363ivs67	61	5	that	that	IN
cord-285806-363ivs67	61	6	SARS	SARS	NNP
cord-285806-363ivs67	61	7	-	-	HYPH
cord-285806-363ivs67	61	8	CoV-1	CoV-1	NNP
cord-285806-363ivs67	61	9	can	can	MD
cord-285806-363ivs67	61	10	directly	directly	RB
cord-285806-363ivs67	61	11	promote	promote	VB
cord-285806-363ivs67	61	12	IL-6	IL-6	NNP
cord-285806-363ivs67	61	13	secretion	secretion	NN
cord-285806-363ivs67	61	14	,	,	,
cord-285806-363ivs67	61	15	this	this	DT
cord-285806-363ivs67	61	16	of	of	IN
cord-285806-363ivs67	61	17	course	course	NN
cord-285806-363ivs67	61	18	is	be	VBZ
cord-285806-363ivs67	61	19	not	not	RB
cord-285806-363ivs67	61	20	the	the	DT
cord-285806-363ivs67	61	21	only	only	JJ
cord-285806-363ivs67	61	22	way	way	NN
cord-285806-363ivs67	61	23	it	-PRON-	PRP
cord-285806-363ivs67	61	24	happens	happen	VBZ
cord-285806-363ivs67	61	25	since	since	IN
cord-285806-363ivs67	61	26	IL-6	IL-6	NNP
cord-285806-363ivs67	61	27	can	can	MD
cord-285806-363ivs67	61	28	be	be	VB
cord-285806-363ivs67	61	29	induced	induce	VBN
cord-285806-363ivs67	61	30	by	by	IN
cord-285806-363ivs67	61	31	so	so	RB
cord-285806-363ivs67	61	32	many	many	JJ
cord-285806-363ivs67	61	33	types	type	NNS
cord-285806-363ivs67	61	34	of	of	IN
cord-285806-363ivs67	61	35	cells	cell	NNS
cord-285806-363ivs67	61	36	and	and	CC
cord-285806-363ivs67	61	37	cytokines	cytokine	NNS
cord-285806-363ivs67	61	38	as	as	IN
cord-285806-363ivs67	61	39	mentioned	mention	VBN
cord-285806-363ivs67	61	40	above	above	RB
cord-285806-363ivs67	61	41	.	.	.
cord-285806-363ivs67	62	1	Among	among	IN
cord-285806-363ivs67	62	2	all	all	DT
cord-285806-363ivs67	62	3	SARS	SARS	NNP
cord-285806-363ivs67	62	4	-	-	HYPH
cord-285806-363ivs67	62	5	CoV-1	CoV-1	NNP
cord-285806-363ivs67	62	6	structural	structural	JJ
cord-285806-363ivs67	62	7	proteins	protein	NNS
cord-285806-363ivs67	62	8	(	(	-LRB-
cord-285806-363ivs67	62	9	nucleocapsid	nucleocapsid	NNP
cord-285806-363ivs67	62	10	N	n	CD
cord-285806-363ivs67	62	11	,	,	,
cord-285806-363ivs67	62	12	spike	spike	NN
cord-285806-363ivs67	62	13	S	S	NNP
cord-285806-363ivs67	62	14	,	,	,
cord-285806-363ivs67	62	15	envelop	envelop	VB
cord-285806-363ivs67	62	16	E	e	NN
cord-285806-363ivs67	62	17	and	and	CC
cord-285806-363ivs67	62	18	membrane	membrane	NN
cord-285806-363ivs67	62	19	M	M	NNP
cord-285806-363ivs67	62	20	)	)	-RRB-
cord-285806-363ivs67	62	21	only	only	RB
cord-285806-363ivs67	62	22	the	the	DT
cord-285806-363ivs67	62	23	nucleocapsid	nucleocapsid	NNP
cord-285806-363ivs67	62	24	protein	protein	NNP
cord-285806-363ivs67	62	25	(	(	-LRB-
cord-285806-363ivs67	62	26	N	N	NNP
cord-285806-363ivs67	62	27	)	)	-RRB-
cord-285806-363ivs67	62	28	significantly	significantly	RB
cord-285806-363ivs67	62	29	induced	induce	VBD
cord-285806-363ivs67	62	30	the	the	DT
cord-285806-363ivs67	62	31	activation	activation	NN
cord-285806-363ivs67	62	32	of	of	IN
cord-285806-363ivs67	62	33	IL-6	IL-6	NNP
cord-285806-363ivs67	62	34	promoter	promoter	NN
cord-285806-363ivs67	62	35	in	in	IN
cord-285806-363ivs67	62	36	human	human	JJ
cord-285806-363ivs67	62	37	airway	airway	NN
cord-285806-363ivs67	62	38	epithelial	epithelial	JJ
cord-285806-363ivs67	62	39	cell	cell	NN
cord-285806-363ivs67	62	40	cultures	culture	NNS
cord-285806-363ivs67	62	41	38	38	CD
cord-285806-363ivs67	62	42	.	.	.
cord-285806-363ivs67	63	1	IL-6	IL-6	NNP
cord-285806-363ivs67	63	2	gene	gene	NN
cord-285806-363ivs67	63	3	expression	expression	NN
cord-285806-363ivs67	63	4	is	be	VBZ
cord-285806-363ivs67	63	5	activated	activate	VBN
cord-285806-363ivs67	63	6	by	by	IN
cord-285806-363ivs67	63	7	the	the	DT
cord-285806-363ivs67	63	8	N	N	NNP
cord-285806-363ivs67	63	9	protein	protein	NN
cord-285806-363ivs67	63	10	which	which	WDT
cord-285806-363ivs67	63	11	binds	bind	VBZ
cord-285806-363ivs67	63	12	to	to	IN
cord-285806-363ivs67	63	13	the	the	DT
cord-285806-363ivs67	63	14	NF	NF	NNP
cord-285806-363ivs67	63	15	-	-	HYPH
cord-285806-363ivs67	63	16	kB	kB	NNP
cord-285806-363ivs67	63	17	regulatory	regulatory	JJ
cord-285806-363ivs67	63	18	element	element	NN
cord-285806-363ivs67	63	19	on	on	IN
cord-285806-363ivs67	63	20	IL-6	IL-6	NNP
cord-285806-363ivs67	63	21	promoter	promoter	NN
cord-285806-363ivs67	63	22	and	and	CC
cord-285806-363ivs67	63	23	facilitates	facilitate	VBZ
cord-285806-363ivs67	63	24	its	-PRON-	PRP$
cord-285806-363ivs67	63	25	translocation	translocation	NN
cord-285806-363ivs67	63	26	from	from	IN
cord-285806-363ivs67	63	27	cytosol	cytosol	NN
cord-285806-363ivs67	63	28	to	to	IN
cord-285806-363ivs67	63	29	nucleus	nucleus	NN
cord-285806-363ivs67	63	30	.	.	.
cord-285806-363ivs67	64	1	The	the	DT
cord-285806-363ivs67	64	2	N	N	NNP
cord-285806-363ivs67	64	3	protein	protein	NN
cord-285806-363ivs67	64	4	is	be	VBZ
cord-285806-363ivs67	64	5	essential	essential	JJ
cord-285806-363ivs67	64	6	for	for	IN
cord-285806-363ivs67	64	7	IL-6	IL-6	NNP
cord-285806-363ivs67	64	8	secretion	secretion	NN
cord-285806-363ivs67	64	9	to	to	TO
cord-285806-363ivs67	64	10	happen	happen	VB
cord-285806-363ivs67	64	11	,	,	,
cord-285806-363ivs67	64	12	since	since	IN
cord-285806-363ivs67	64	13	deletion	deletion	NN
cord-285806-363ivs67	64	14	of	of	IN
cord-285806-363ivs67	64	15	the	the	DT
cord-285806-363ivs67	64	16	C	c	NN
cord-285806-363ivs67	64	17	-	-	HYPH
cord-285806-363ivs67	64	18	terminus	terminus	NN
cord-285806-363ivs67	64	19	of	of	IN
cord-285806-363ivs67	64	20	the	the	DT
cord-285806-363ivs67	64	21	N	N	NNP
cord-285806-363ivs67	64	22	protein	protein	NN
cord-285806-363ivs67	64	23	resulted	result	VBD
cord-285806-363ivs67	64	24	in	in	IN
cord-285806-363ivs67	64	25	the	the	DT
cord-285806-363ivs67	64	26	loss	loss	NN
cord-285806-363ivs67	64	27	of	of	IN
cord-285806-363ivs67	64	28	function	function	NN
cord-285806-363ivs67	64	29	in	in	IN
cord-285806-363ivs67	64	30	the	the	DT
cord-285806-363ivs67	64	31	activation	activation	NN
cord-285806-363ivs67	64	32	of	of	IN
cord-285806-363ivs67	64	33	IL-6	IL-6	NNP
cord-285806-363ivs67	64	34	38	38	CD
cord-285806-363ivs67	64	35	.	.	.
cord-285806-363ivs67	65	1	More	More	JJR
cord-285806-363ivs67	65	2	evidence	evidence	NN
cord-285806-363ivs67	65	3	is	be	VBZ
cord-285806-363ivs67	65	4	emerging	emerge	VBG
cord-285806-363ivs67	65	5	of	of	IN
cord-285806-363ivs67	65	6	many	many	JJ
cord-285806-363ivs67	65	7	similarities	similarity	NNS
cord-285806-363ivs67	65	8	between	between	IN
cord-285806-363ivs67	65	9	Macrophage	Macrophage	NNP
cord-285806-363ivs67	65	10	Activation	Activation	NNP
cord-285806-363ivs67	65	11	Syndrome	Syndrome	NNP
cord-285806-363ivs67	65	12	(	(	-LRB-
cord-285806-363ivs67	65	13	MAS	MAS	NNP
cord-285806-363ivs67	65	14	)	)	-RRB-
cord-285806-363ivs67	65	15	disease	disease	NN
cord-285806-363ivs67	65	16	and	and	CC
cord-285806-363ivs67	65	17	COVID-19	COVID-19	NNP
cord-285806-363ivs67	65	18	pneumonia	pneumonia	NN
cord-285806-363ivs67	65	19	.	.	.
cord-285806-363ivs67	66	1	Similarities	similarity	NNS
cord-285806-363ivs67	66	2	include	include	VBP
cord-285806-363ivs67	66	3	pathological	pathological	JJ
cord-285806-363ivs67	66	4	findings	finding	NNS
cord-285806-363ivs67	66	5	and	and	CC
cord-285806-363ivs67	66	6	a	a	DT
cord-285806-363ivs67	66	7	"	"	``
cord-285806-363ivs67	66	8	second	second	JJ
cord-285806-363ivs67	66	9	wave	wave	NN
cord-285806-363ivs67	66	10	"	"	''
cord-285806-363ivs67	66	11	of	of	IN
cord-285806-363ivs67	66	12	cytokine	cytokine	JJ
cord-285806-363ivs67	66	13	secretion	secretion	NN
cord-285806-363ivs67	66	14	.	.	.
cord-285806-363ivs67	67	1	The	the	DT
cord-285806-363ivs67	67	2	loss	loss	NN
cord-285806-363ivs67	67	3	of	of	IN
cord-285806-363ivs67	67	4	"	"	``
cord-285806-363ivs67	67	5	front	front	JJ
cord-285806-363ivs67	67	6	line	line	NN
cord-285806-363ivs67	67	7	"	"	``
cord-285806-363ivs67	67	8	anti	anti	JJ
cord-285806-363ivs67	67	9	-	-	JJ
cord-285806-363ivs67	67	10	viral	viral	JJ
cord-285806-363ivs67	67	11	defence	defence	NN
cord-285806-363ivs67	67	12	mechanism	mechanism	NN
cord-285806-363ivs67	67	13	may	may	MD
cord-285806-363ivs67	67	14	be	be	VB
cord-285806-363ivs67	67	15	responsible	responsible	JJ
cord-285806-363ivs67	67	16	for	for	IN
cord-285806-363ivs67	67	17	this	this	DT
cord-285806-363ivs67	67	18	"	"	``
cord-285806-363ivs67	67	19	second	second	JJ
cord-285806-363ivs67	67	20	wave	wave	NN
cord-285806-363ivs67	67	21	"	"	''
cord-285806-363ivs67	67	22	activation	activation	NN
cord-285806-363ivs67	67	23	,	,	,
cord-285806-363ivs67	67	24	thus	thus	RB
cord-285806-363ivs67	67	25	prolonging	prolong	VBG
cord-285806-363ivs67	67	26	IL-6	IL-6	NNP
cord-285806-363ivs67	67	27	secretion	secretion	NN
cord-285806-363ivs67	67	28	39	39	CD
cord-285806-363ivs67	67	29	.	.	.
cord-285806-363ivs67	68	1	Sustained	sustain	VBN
cord-285806-363ivs67	68	2	IL-6	IL-6	NNP
cord-285806-363ivs67	68	3	secretion	secretion	NN
cord-285806-363ivs67	68	4	has	have	VBZ
cord-285806-363ivs67	68	5	also	also	RB
cord-285806-363ivs67	68	6	been	be	VBN
cord-285806-363ivs67	68	7	correlated	correlate	VBN
cord-285806-363ivs67	68	8	to	to	IN
cord-285806-363ivs67	68	9	serum	serum	NN
cord-285806-363ivs67	68	10	viral	viral	JJ
cord-285806-363ivs67	68	11	RNA	RNA	NNP
cord-285806-363ivs67	68	12	load	load	NN
cord-285806-363ivs67	68	13	40	40	CD
cord-285806-363ivs67	68	14	-End	-end	NN
cord-285806-363ivs67	68	15	of	of	IN
cord-285806-363ivs67	68	16	the	the	DT
cord-285806-363ivs67	68	17	initial	initial	JJ
cord-285806-363ivs67	68	18	phase	phase	NN
cord-285806-363ivs67	68	19	of	of	IN
cord-285806-363ivs67	68	20	high	high	JJ
cord-285806-363ivs67	68	21	viral	viral	JJ
cord-285806-363ivs67	68	22	load	load	NN
cord-285806-363ivs67	68	23	of	of	IN
cord-285806-363ivs67	68	24	COVID-19	COVID-19	NNP
cord-285806-363ivs67	68	25	(	(	-LRB-
cord-285806-363ivs67	68	26	patient	patient	JJ
cord-285806-363ivs67	68	27	with	with	IN
cord-285806-363ivs67	68	28	no	no	DT
cord-285806-363ivs67	68	29	fever	fever	NN
cord-285806-363ivs67	68	30	for	for	IN
cord-285806-363ivs67	68	31	more	more	JJR
cord-285806-363ivs67	68	32	than	than	IN
cord-285806-363ivs67	68	33	72	72	CD
cord-285806-363ivs67	68	34	hours	hour	NNS
cord-285806-363ivs67	68	35	and/or	and/or	CC
cord-285806-363ivs67	68	36	more	more	JJR
cord-285806-363ivs67	68	37	than	than	IN
cord-285806-363ivs67	68	38	7	7	CD
cord-285806-363ivs67	68	39	days	day	NNS
cord-285806-363ivs67	68	40	from	from	IN
cord-285806-363ivs67	68	41	the	the	DT
cord-285806-363ivs67	68	42	symptoms	symptom	NNS
cord-285806-363ivs67	68	43	onset	onset	NN
cord-285806-363ivs67	68	44	)	)	-RRB-
cord-285806-363ivs67	69	1	-Worsening	-worsene	VBG
cord-285806-363ivs67	69	2	of	of	IN
cord-285806-363ivs67	69	3	the	the	DT
cord-285806-363ivs67	69	4	respiratory	respiratory	JJ
cord-285806-363ivs67	69	5	condition	condition	NN
cord-285806-363ivs67	69	6	requiring	require	VBG
cord-285806-363ivs67	69	7	invasive	invasive	JJ
cord-285806-363ivs67	69	8	or	or	CC
cord-285806-363ivs67	69	9	non	non	JJ
cord-285806-363ivs67	69	10	invasive	invasive	JJ
cord-285806-363ivs67	69	11	ventilation	ventilation	NN
cord-285806-363ivs67	69	12	support	support	NN
cord-285806-363ivs67	70	1	-Elevated	-Elevated	.
cord-285806-363ivs67	71	1	levels	level	NNS
cord-285806-363ivs67	71	2	of	of	IN
cord-285806-363ivs67	71	3	IL-6	IL-6	NNP
cord-285806-363ivs67	71	4	(	(	-LRB-
cord-285806-363ivs67	71	5	more	more	JJR
cord-285806-363ivs67	71	6	than	than	IN
cord-285806-363ivs67	71	7	40	40	CD
cord-285806-363ivs67	71	8	pg	pg	NNS
cord-285806-363ivs67	71	9	/	/	SYM
cord-285806-363ivs67	71	10	ml	ml	NN
cord-285806-363ivs67	71	11	)	)	-RRB-
cord-285806-363ivs67	71	12	;	;	:
cord-285806-363ivs67	71	13	or	or	CC
cord-285806-363ivs67	71	14	high	high	JJ
cord-285806-363ivs67	71	15	levels	level	NNS
cord-285806-363ivs67	71	16	of	of	IN
cord-285806-363ivs67	71	17	D	D	NNP
cord-285806-363ivs67	71	18	-	-	HYPH
cord-285806-363ivs67	71	19	Dimer	Dimer	NNP
cord-285806-363ivs67	71	20	and/or	and/or	CC
cord-285806-363ivs67	71	21	PCR	PCR	NNP
cord-285806-363ivs67	71	22	and/or	and/or	CC
cord-285806-363ivs67	71	23	ferritin	ferritin	NN
cord-285806-363ivs67	71	24	and/or	and/or	CC
cord-285806-363ivs67	71	25	progressive	progressive	JJ
cord-285806-363ivs67	71	26	increasingly	increasingly	RB
cord-285806-363ivs67	71	27	level	level	NN
cord-285806-363ivs67	71	28	of	of	IN
cord-285806-363ivs67	71	29	fibrinogen	fibrinogen	NN
cord-285806-363ivs67	71	30	.	.	.
cord-285806-363ivs67	72	1	The	the	DT
cord-285806-363ivs67	72	2	signal	signal	NN
cord-285806-363ivs67	72	3	transduction	transduction	NN
cord-285806-363ivs67	72	4	of	of	IN
cord-285806-363ivs67	72	5	IL-6	IL-6	NNP
cord-285806-363ivs67	72	6	is	be	VBZ
cord-285806-363ivs67	72	7	induced	induce	VBN
cord-285806-363ivs67	72	8	by	by	IN
cord-285806-363ivs67	72	9	binding	bind	VBG
cord-285806-363ivs67	72	10	of	of	IN
cord-285806-363ivs67	72	11	IL-6	IL-6	NNP
cord-285806-363ivs67	72	12	to	to	IN
cord-285806-363ivs67	72	13	its	-PRON-	PRP$
cord-285806-363ivs67	72	14	alpha	alpha	NN
cord-285806-363ivs67	72	15	receptor	receptor	NN
cord-285806-363ivs67	72	16	,	,	,
cord-285806-363ivs67	73	1	Interleukin-6	Interleukin-6	NNP
cord-285806-363ivs67	74	1	Receptor	receptor	NN
cord-285806-363ivs67	74	2	(	(	-LRB-
cord-285806-363ivs67	74	3	IL-6R	IL-6R	NNP
cord-285806-363ivs67	74	4	)	)	-RRB-
cord-285806-363ivs67	74	5	.	.	.
cord-285806-363ivs67	75	1	The	the	DT
cord-285806-363ivs67	75	2	complex	complex	NN
cord-285806-363ivs67	75	3	formed	form	VBN
cord-285806-363ivs67	75	4	by	by	IN
cord-285806-363ivs67	75	5	IL-6	IL-6	NNP
cord-285806-363ivs67	75	6	and	and	CC
cord-285806-363ivs67	75	7	its	-PRON-	PRP$
cord-285806-363ivs67	75	8	receptor	receptor	NN
cord-285806-363ivs67	75	9	in	in	IN
cord-285806-363ivs67	75	10	turn	turn	NN
cord-285806-363ivs67	75	11	activates	activate	VBZ
cord-285806-363ivs67	75	12	a	a	DT
cord-285806-363ivs67	75	13	homodimer	homodimer	NN
cord-285806-363ivs67	75	14	of	of	IN
cord-285806-363ivs67	75	15	the	the	DT
cord-285806-363ivs67	75	16	signal	signal	NN
cord-285806-363ivs67	75	17	transduction	transduction	NN
cord-285806-363ivs67	75	18	beta	beta	NN
cord-285806-363ivs67	75	19	-	-	HYPH
cord-285806-363ivs67	75	20	receptor	receptor	NN
cord-285806-363ivs67	75	21	gp130	gp130	NNS
cord-285806-363ivs67	75	22	with	with	IN
cord-285806-363ivs67	75	23	high	high	JJ
cord-285806-363ivs67	75	24	affinity	affinity	NN
cord-285806-363ivs67	75	25	44	44	CD
cord-285806-363ivs67	75	26	.	.	.
cord-285806-363ivs67	76	1	The	the	DT
cord-285806-363ivs67	76	2	gp130	gp130	NNP
cord-285806-363ivs67	76	3	receptor	receptor	NN
cord-285806-363ivs67	76	4	thereupon	thereupon	RB
cord-285806-363ivs67	76	5	dimerizes	dimerizes	NNP
cord-285806-363ivs67	76	6	and	and	CC
cord-285806-363ivs67	76	7	initiates	initiate	VBZ
cord-285806-363ivs67	76	8	intracellular	intracellular	JJ
cord-285806-363ivs67	76	9	signal	signal	NN
cord-285806-363ivs67	76	10	transduction	transduction	NN
cord-285806-363ivs67	76	11	by	by	IN
cord-285806-363ivs67	76	12	activating	activate	VBG
cord-285806-363ivs67	76	13	the	the	DT
cord-285806-363ivs67	76	14	JAK	JAK	NNP
cord-285806-363ivs67	76	15	/	/	SYM
cord-285806-363ivs67	76	16	STAT	STAT	NNP
cord-285806-363ivs67	76	17	and	and	CC
cord-285806-363ivs67	76	18	ras	ras	NNP
cord-285806-363ivs67	76	19	/	/	SYM
cord-285806-363ivs67	76	20	MAP	MAP	NNP
cord-285806-363ivs67	76	21	kinase	kinase	NN
cord-285806-363ivs67	76	22	pathways	pathway	NNS
cord-285806-363ivs67	76	23	45	45	CD
cord-285806-363ivs67	76	24	.	.	.
cord-285806-363ivs67	77	1	Gp130	Gp130	NNP
cord-285806-363ivs67	77	2	is	be	VBZ
cord-285806-363ivs67	77	3	expressed	express	VBN
cord-285806-363ivs67	77	4	on	on	IN
cord-285806-363ivs67	77	5	all	all	DT
cord-285806-363ivs67	77	6	cells	cell	NNS
cord-285806-363ivs67	77	7	of	of	IN
cord-285806-363ivs67	77	8	the	the	DT
cord-285806-363ivs67	77	9	human	human	JJ
cord-285806-363ivs67	77	10	body	body	NN
cord-285806-363ivs67	77	11	.	.	.
cord-285806-363ivs67	78	1	IL-6	IL-6	NNP
cord-285806-363ivs67	78	2	Receptor	Receptor	NNP
cord-285806-363ivs67	78	3	instead	instead	RB
cord-285806-363ivs67	78	4	is	be	VBZ
cord-285806-363ivs67	78	5	mainly	mainly	RB
cord-285806-363ivs67	78	6	found	find	VBN
cord-285806-363ivs67	78	7	on	on	IN
cord-285806-363ivs67	78	8	hepatocytes	hepatocyte	NNS
cord-285806-363ivs67	78	9	,	,	,
cord-285806-363ivs67	78	10	some	some	DT
cord-285806-363ivs67	78	11	leukocytes	leukocyte	NNS
cord-285806-363ivs67	78	12	,	,	,
cord-285806-363ivs67	78	13	and	and	CC
cord-285806-363ivs67	78	14	epithelial	epithelial	JJ
cord-285806-363ivs67	78	15	cells	cell	NNS
cord-285806-363ivs67	79	1	46	46	CD
cord-285806-363ivs67	79	2	.	.	.
cord-285806-363ivs67	80	1	The	the	DT
cord-285806-363ivs67	80	2	IL-6	IL-6	NNP
cord-285806-363ivs67	80	3	Receptor	Receptor	NNP
cord-285806-363ivs67	80	4	(	(	-LRB-
cord-285806-363ivs67	80	5	IL-6R	IL-6R	NNP
cord-285806-363ivs67	80	6	)	)	-RRB-
cord-285806-363ivs67	80	7	protein	protein	NN
cord-285806-363ivs67	80	8	is	be	VBZ
cord-285806-363ivs67	80	9	subjected	subject	VBN
cord-285806-363ivs67	80	10	to	to	IN
cord-285806-363ivs67	80	11	limited	limited	JJ
cord-285806-363ivs67	80	12	proteolysis	proteolysis	NN
cord-285806-363ivs67	80	13	by	by	IN
cord-285806-363ivs67	80	14	a	a	DT
cord-285806-363ivs67	80	15	metalloprotease	metalloprotease	NNP
cord-285806-363ivs67	80	16	activity	activity	NN
cord-285806-363ivs67	80	17	which	which	WDT
cord-285806-363ivs67	80	18	gives	give	VBZ
cord-285806-363ivs67	80	19	rises	rise	NNS
cord-285806-363ivs67	80	20	to	to	IN
cord-285806-363ivs67	80	21	a	a	DT
cord-285806-363ivs67	80	22	soluble	soluble	JJ
cord-285806-363ivs67	80	23	form	form	NN
cord-285806-363ivs67	80	24	of	of	IN
cord-285806-363ivs67	80	25	IL-6R	IL-6R	NNP
cord-285806-363ivs67	80	26	(	(	-LRB-
cord-285806-363ivs67	80	27	sIL-6R	sIL-6R	NNP
cord-285806-363ivs67	80	28	)	)	-RRB-
cord-285806-363ivs67	80	29	47	47	CD
cord-285806-363ivs67	80	30	.	.	.
cord-285806-363ivs67	81	1	The	the	DT
cord-285806-363ivs67	81	2	majority	majority	NN
cord-285806-363ivs67	81	3	of	of	IN
cord-285806-363ivs67	81	4	the	the	DT
cord-285806-363ivs67	81	5	soluble	soluble	JJ
cord-285806-363ivs67	81	6	IL-6R	IL-6R	NNPS
cord-285806-363ivs67	81	7	found	find	VBN
cord-285806-363ivs67	81	8	in	in	IN
cord-285806-363ivs67	81	9	the	the	DT
cord-285806-363ivs67	81	10	circulation	circulation	NN
cord-285806-363ivs67	81	11	is	be	VBZ
cord-285806-363ivs67	81	12	proteolytically	proteolytically	RB
cord-285806-363ivs67	81	13	cleaved	cleave	VBN
cord-285806-363ivs67	81	14	from	from	IN
cord-285806-363ivs67	81	15	cells	cell	NNS
cord-285806-363ivs67	81	16	by	by	IN
cord-285806-363ivs67	81	17	the	the	DT
cord-285806-363ivs67	81	18	protease	protease	NN
cord-285806-363ivs67	81	19	ADAM17	adam17	CD
cord-285806-363ivs67	81	20	48	48	CD
cord-285806-363ivs67	81	21	,	,	,
cord-285806-363ivs67	81	22	49	49	CD
cord-285806-363ivs67	81	23	.	.	.
cord-285806-363ivs67	82	1	A	a	DT
cord-285806-363ivs67	82	2	minor	minor	JJ
cord-285806-363ivs67	82	3	portion	portion	NN
cord-285806-363ivs67	82	4	of	of	IN
cord-285806-363ivs67	82	5	the	the	DT
cord-285806-363ivs67	82	6	sIL-6R	sIL-6R	NNP
cord-285806-363ivs67	82	7	is	be	VBZ
cord-285806-363ivs67	82	8	generated	generate	VBN
cord-285806-363ivs67	82	9	from	from	IN
cord-285806-363ivs67	82	10	an	an	DT
cord-285806-363ivs67	82	11	alternatively	alternatively	RB
cord-285806-363ivs67	82	12	spliced	splice	VBN
cord-285806-363ivs67	82	13	mRNA	mRNA	NNP
cord-285806-363ivs67	82	14	50	50	CD
cord-285806-363ivs67	82	15	,	,	,
cord-285806-363ivs67	82	16	but	but	CC
cord-285806-363ivs67	82	17	limited	limited	JJ
cord-285806-363ivs67	82	18	proteolysis	proteolysis	NN
cord-285806-363ivs67	82	19	remains	remain	VBZ
cord-285806-363ivs67	82	20	the	the	DT
cord-285806-363ivs67	82	21	major	major	JJ
cord-285806-363ivs67	82	22	mechanism	mechanism	NN
cord-285806-363ivs67	82	23	by	by	IN
cord-285806-363ivs67	82	24	which	which	WDT
cord-285806-363ivs67	82	25	the	the	DT
cord-285806-363ivs67	82	26	sIL-6R	sIL-6R	NNP
cord-285806-363ivs67	82	27	is	be	VBZ
cord-285806-363ivs67	82	28	generated	generate	VBN
cord-285806-363ivs67	82	29	51	51	CD
cord-285806-363ivs67	82	30	.	.	.
cord-285806-363ivs67	83	1	For	for	IN
cord-285806-363ivs67	83	2	signal	signal	NN
cord-285806-363ivs67	83	3	transduction	transduction	NN
cord-285806-363ivs67	83	4	the	the	DT
cord-285806-363ivs67	83	5	IL-6R	IL-6R	NNP
cord-285806-363ivs67	83	6	can	can	MD
cord-285806-363ivs67	83	7	either	either	CC
cord-285806-363ivs67	83	8	be	be	VB
cord-285806-363ivs67	83	9	membrane	membrane	NN
cord-285806-363ivs67	83	10	bound	bind	VBN
cord-285806-363ivs67	83	11	(	(	-LRB-
cord-285806-363ivs67	83	12	classic	classic	JJ
cord-285806-363ivs67	83	13	pathway	pathway	NN
cord-285806-363ivs67	83	14	)	)	-RRB-
cord-285806-363ivs67	83	15	or	or	CC
cord-285806-363ivs67	83	16	soluble	soluble	JJ
cord-285806-363ivs67	83	17	(	(	-LRB-
cord-285806-363ivs67	83	18	trans	trans	JJ
cord-285806-363ivs67	83	19	-	-	JJ
cord-285806-363ivs67	83	20	signaling	signal	VBG
cord-285806-363ivs67	83	21	pathway	pathway	NN
cord-285806-363ivs67	83	22	)	)	-RRB-
cord-285806-363ivs67	83	23	51	51	CD
cord-285806-363ivs67	83	24	.	.	.
cord-285806-363ivs67	84	1	Those	those	DT
cord-285806-363ivs67	84	2	two	two	CD
cord-285806-363ivs67	84	3	different	different	JJ
cord-285806-363ivs67	84	4	pathways	pathway	NNS
cord-285806-363ivs67	84	5	of	of	IN
cord-285806-363ivs67	84	6	signal	signal	NN
cord-285806-363ivs67	84	7	transduction	transduction	NN
cord-285806-363ivs67	84	8	seem	seem	VBP
cord-285806-363ivs67	84	9	to	to	TO
cord-285806-363ivs67	84	10	have	have	VB
cord-285806-363ivs67	84	11	different	different	JJ
cord-285806-363ivs67	84	12	and	and	CC
cord-285806-363ivs67	84	13	divergent	divergent	JJ
cord-285806-363ivs67	84	14	functions	function	NNS
cord-285806-363ivs67	84	15	.	.	.
cord-285806-363ivs67	85	1	In	in	IN
cord-285806-363ivs67	85	2	the	the	DT
cord-285806-363ivs67	85	3	trans	trans	NN
cord-285806-363ivs67	85	4	signaling	signaling	NN
cord-285806-363ivs67	85	5	,	,	,
cord-285806-363ivs67	85	6	the	the	DT
cord-285806-363ivs67	85	7	complex	complex	NN
cord-285806-363ivs67	85	8	of	of	IN
cord-285806-363ivs67	85	9	sIL-6R	sIL-6R	NNP
cord-285806-363ivs67	85	10	and	and	CC
cord-285806-363ivs67	85	11	IL-6	IL-6	NNP
cord-285806-363ivs67	85	12	binds	bind	VBZ
cord-285806-363ivs67	85	13	to	to	IN
cord-285806-363ivs67	85	14	and	and	CC
cord-285806-363ivs67	85	15	activates	activate	VBZ
cord-285806-363ivs67	85	16	gp130	gp130	NNS
cord-285806-363ivs67	85	17	even	even	RB
cord-285806-363ivs67	85	18	on	on	IN
cord-285806-363ivs67	85	19	cells	cell	NNS
cord-285806-363ivs67	85	20	that	that	WDT
cord-285806-363ivs67	85	21	do	do	VBP
cord-285806-363ivs67	85	22	not	not	RB
cord-285806-363ivs67	85	23	express	express	VB
cord-285806-363ivs67	85	24	IL-6R	IL-6R	NNP
cord-285806-363ivs67	85	25	52	52	CD
cord-285806-363ivs67	85	26	.	.	.
cord-285806-363ivs67	86	1	This	this	DT
cord-285806-363ivs67	86	2	is	be	VBZ
cord-285806-363ivs67	86	3	an	an	DT
cord-285806-363ivs67	86	4	important	important	JJ
cord-285806-363ivs67	86	5	mechanism	mechanism	NN
cord-285806-363ivs67	86	6	since	since	IN
cord-285806-363ivs67	86	7	only	only	RB
cord-285806-363ivs67	86	8	a	a	DT
cord-285806-363ivs67	86	9	few	few	JJ
cord-285806-363ivs67	86	10	cells	cell	NNS
cord-285806-363ivs67	86	11	in	in	IN
cord-285806-363ivs67	86	12	the	the	DT
cord-285806-363ivs67	86	13	human	human	JJ
cord-285806-363ivs67	86	14	body	body	NN
cord-285806-363ivs67	86	15	express	express	VBP
cord-285806-363ivs67	86	16	IL-6R	IL-6R	NNP
cord-285806-363ivs67	86	17	,	,	,
cord-285806-363ivs67	86	18	whereas	whereas	IN
cord-285806-363ivs67	86	19	the	the	DT
cord-285806-363ivs67	86	20	majority	majority	NN
cord-285806-363ivs67	86	21	of	of	IN
cord-285806-363ivs67	86	22	cells	cell	NNS
cord-285806-363ivs67	86	23	do	do	VBP
cord-285806-363ivs67	86	24	not	not	RB
cord-285806-363ivs67	86	25	show	show	VB
cord-285806-363ivs67	86	26	IL-6R	IL-6R	NNP
cord-285806-363ivs67	86	27	expression	expression	NN
cord-285806-363ivs67	86	28	53	53	CD
cord-285806-363ivs67	86	29	,	,	,
cord-285806-363ivs67	86	30	54	54	CD
cord-285806-363ivs67	86	31	.	.	.
cord-285806-363ivs67	87	1	Since	since	IN
cord-285806-363ivs67	87	2	all	all	DT
cord-285806-363ivs67	87	3	cells	cell	NNS
cord-285806-363ivs67	87	4	express	express	VBP
cord-285806-363ivs67	87	5	gp130	gp130	NNS
cord-285806-363ivs67	87	6	,	,	,
cord-285806-363ivs67	87	7	all	all	DT
cord-285806-363ivs67	87	8	of	of	IN
cord-285806-363ivs67	87	9	them	-PRON-	PRP
cord-285806-363ivs67	87	10	are	be	VBP
cord-285806-363ivs67	87	11	in	in	IN
cord-285806-363ivs67	87	12	theory	theory	NN
cord-285806-363ivs67	87	13	possible	possible	JJ
cord-285806-363ivs67	87	14	target	target	NN
cord-285806-363ivs67	87	15	cells	cell	NNS
cord-285806-363ivs67	87	16	of	of	IN
cord-285806-363ivs67	87	17	IL-6	IL-6	NNP
cord-285806-363ivs67	87	18	trans	trans	NNP
cord-285806-363ivs67	87	19	signaling	signal	VBG
cord-285806-363ivs67	87	20	52	52	CD
cord-285806-363ivs67	87	21	.	.	.
cord-285806-363ivs67	88	1	Trans	Trans	NNP
cord-285806-363ivs67	88	2	-	-	NN
cord-285806-363ivs67	88	3	signaling	signaling	NN
cord-285806-363ivs67	88	4	is	be	VBZ
cord-285806-363ivs67	88	5	believed	believe	VBN
cord-285806-363ivs67	88	6	to	to	TO
cord-285806-363ivs67	88	7	be	be	VB
cord-285806-363ivs67	88	8	involved	involve	VBN
cord-285806-363ivs67	88	9	in	in	IN
cord-285806-363ivs67	88	10	chronic	chronic	JJ
cord-285806-363ivs67	88	11	inflammation	inflammation	NN
cord-285806-363ivs67	88	12	and	and	CC
cord-285806-363ivs67	88	13	cancer	cancer	NN
cord-285806-363ivs67	88	14	development	development	NN
cord-285806-363ivs67	88	15	55	55	CD
cord-285806-363ivs67	88	16	.	.	.
cord-285806-363ivs67	89	1	Some	some	DT
cord-285806-363ivs67	89	2	animal	animal	NN
cord-285806-363ivs67	89	3	models	model	NNS
cord-285806-363ivs67	89	4	showed	show	VBD
cord-285806-363ivs67	89	5	that	that	IN
cord-285806-363ivs67	89	6	when	when	WRB
cord-285806-363ivs67	89	7	IL-6	IL-6	NNP
cord-285806-363ivs67	89	8	was	be	VBD
cord-285806-363ivs67	89	9	acting	act	VBG
cord-285806-363ivs67	89	10	via	via	IN
cord-285806-363ivs67	89	11	the	the	DT
cord-285806-363ivs67	89	12	membrane	membrane	NN
cord-285806-363ivs67	89	13	bound	bind	VBN
cord-285806-363ivs67	90	1	IL-6R	IL-6R	NNP
cord-285806-363ivs67	91	1	(	(	-LRB-
cord-285806-363ivs67	91	2	classic	classic	JJ
cord-285806-363ivs67	91	3	signaling	signaling	NN
cord-285806-363ivs67	91	4	)	)	-RRB-
cord-285806-363ivs67	92	1	it	-PRON-	PRP
cord-285806-363ivs67	92	2	did	do	VBD
cord-285806-363ivs67	92	3	so	so	RB
cord-285806-363ivs67	93	1	in	in	IN
cord-285806-363ivs67	93	2	a	a	DT
cord-285806-363ivs67	93	3	protective	protective	JJ
cord-285806-363ivs67	93	4	way	way	NN
cord-285806-363ivs67	93	5	,	,	,
cord-285806-363ivs67	93	6	they	-PRON-	PRP
cord-285806-363ivs67	93	7	also	also	RB
cord-285806-363ivs67	93	8	showed	show	VBD
cord-285806-363ivs67	93	9	that	that	IN
cord-285806-363ivs67	93	10	inhibiting	inhibit	VBG
cord-285806-363ivs67	93	11	trans	trans	NN
cord-285806-363ivs67	93	12	-	-	NN
cord-285806-363ivs67	93	13	signaling	signaling	NN
cord-285806-363ivs67	93	14	was	be	VBD
cord-285806-363ivs67	93	15	superior	superior	JJ
cord-285806-363ivs67	93	16	to	to	IN
cord-285806-363ivs67	93	17	global	global	JJ
cord-285806-363ivs67	93	18	blockade	blockade	NN
cord-285806-363ivs67	93	19	of	of	IN
cord-285806-363ivs67	93	20	IL-6	IL-6	NNP
cord-285806-363ivs67	93	21	activity	activity	NN
cord-285806-363ivs67	93	22	by	by	IN
cord-285806-363ivs67	93	23	neutralizing	neutralize	VBG
cord-285806-363ivs67	93	24	antibodies	antibody	NNS
cord-285806-363ivs67	93	25	56	56	CD
cord-285806-363ivs67	93	26	,	,	,
cord-285806-363ivs67	93	27	this	this	DT
cord-285806-363ivs67	93	28	was	be	VBD
cord-285806-363ivs67	93	29	done	do	VBN
cord-285806-363ivs67	93	30	using	use	VBG
cord-285806-363ivs67	93	31	the	the	DT
cord-285806-363ivs67	93	32	IL-6	IL-6	NNP
cord-285806-363ivs67	93	33	trans	trans	NNP
cord-285806-363ivs67	93	34	-	-	JJ
cord-285806-363ivs67	93	35	signaling	signal	VBG
cord-285806-363ivs67	93	36	inhibitor	inhibitor	NN
cord-285806-363ivs67	93	37	sgp130Fc	sgp130fc	NN
cord-285806-363ivs67	93	38	,	,	,
cord-285806-363ivs67	93	39	which	which	WDT
cord-285806-363ivs67	93	40	is	be	VBZ
cord-285806-363ivs67	93	41	a	a	DT
cord-285806-363ivs67	93	42	fusion	fusion	NN
cord-285806-363ivs67	93	43	protein	protein	NN
cord-285806-363ivs67	93	44	of	of	IN
cord-285806-363ivs67	93	45	the	the	DT
cord-285806-363ivs67	93	46	gp130	gp130	NNS
cord-285806-363ivs67	93	47	with	with	IN
cord-285806-363ivs67	93	48	the	the	DT
cord-285806-363ivs67	93	49	Fc	Fc	NNP
cord-285806-363ivs67	93	50	portion	portion	NN
cord-285806-363ivs67	93	51	of	of	IN
cord-285806-363ivs67	93	52	a	a	DT
cord-285806-363ivs67	93	53	human	human	JJ
cord-285806-363ivs67	93	54	immunoglobulin	immunoglobulin	NN
cord-285806-363ivs67	93	55	antibody	antibody	NN
cord-285806-363ivs67	93	56	57	57	CD
cord-285806-363ivs67	93	57	,	,	,
cord-285806-363ivs67	93	58	58	58	CD
cord-285806-363ivs67	93	59	.	.	.
cord-285806-363ivs67	94	1	In	in	IN
cord-285806-363ivs67	94	2	a	a	DT
cord-285806-363ivs67	94	3	murine	murine	JJ
cord-285806-363ivs67	94	4	polymicrobial	polymicrobial	JJ
cord-285806-363ivs67	94	5	sepsis	sepsis	NN
cord-285806-363ivs67	94	6	model	model	NN
cord-285806-363ivs67	94	7	,	,	,
cord-285806-363ivs67	94	8	selective	selective	JJ
cord-285806-363ivs67	94	9	blockade	blockade	NN
cord-285806-363ivs67	94	10	of	of	IN
cord-285806-363ivs67	94	11	IL-6	IL-6	NNP
cord-285806-363ivs67	94	12	trans	trans	NNP
cord-285806-363ivs67	94	13	-	-	NN
cord-285806-363ivs67	94	14	signaling	signal	VBG
cord-285806-363ivs67	94	15	with	with	IN
cord-285806-363ivs67	94	16	sgp130Fc	sgp130fc	ADD
cord-285806-363ivs67	94	17	improved	improve	VBN
cord-285806-363ivs67	94	18	survival	survival	NN
cord-285806-363ivs67	94	19	up	up	IN
cord-285806-363ivs67	94	20	to	to	TO
cord-285806-363ivs67	94	21	100	100	CD
cord-285806-363ivs67	94	22	%	%	NN
cord-285806-363ivs67	94	23	.	.	.
cord-285806-363ivs67	95	1	Interestingly	interestingly	RB
cord-285806-363ivs67	95	2	,	,	,
cord-285806-363ivs67	95	3	treating	treat	VBG
cord-285806-363ivs67	95	4	these	these	DT
cord-285806-363ivs67	95	5	mice	mouse	NNS
cord-285806-363ivs67	95	6	with	with	IN
cord-285806-363ivs67	95	7	anti	anti	JJ
cord-285806-363ivs67	95	8	-	-	JJ
cord-285806-363ivs67	95	9	IL-6R	il-6r	JJ
cord-285806-363ivs67	95	10	antibodies	antibody	NNS
cord-285806-363ivs67	95	11	did	do	VBD
cord-285806-363ivs67	95	12	not	not	RB
cord-285806-363ivs67	95	13	prevent	prevent	VB
cord-285806-363ivs67	95	14	death	death	NN
cord-285806-363ivs67	95	15	of	of	IN
cord-285806-363ivs67	95	16	the	the	DT
cord-285806-363ivs67	95	17	mice	mouse	NNS
cord-285806-363ivs67	95	18	56	56	CD
cord-285806-363ivs67	95	19	.	.	.
cord-285806-363ivs67	96	1	This	this	DT
cord-285806-363ivs67	96	2	is	be	VBZ
cord-285806-363ivs67	96	3	a	a	DT
cord-285806-363ivs67	96	4	first	first	JJ
cord-285806-363ivs67	96	5	hint	hint	NN
cord-285806-363ivs67	96	6	of	of	IN
cord-285806-363ivs67	96	7	how	how	WRB
cord-285806-363ivs67	96	8	targeting	target	VBG
cord-285806-363ivs67	96	9	only	only	RB
cord-285806-363ivs67	96	10	the	the	DT
cord-285806-363ivs67	96	11	IL-6R	IL-6R	NNP
cord-285806-363ivs67	96	12	with	with	IN
cord-285806-363ivs67	96	13	drugs	drug	NNS
cord-285806-363ivs67	96	14	like	like	IN
cord-285806-363ivs67	96	15	Tocilizumab	Tocilizumab	NNP
cord-285806-363ivs67	96	16	might	may	MD
cord-285806-363ivs67	96	17	not	not	RB
cord-285806-363ivs67	96	18	be	be	VB
cord-285806-363ivs67	96	19	enough	enough	JJ
cord-285806-363ivs67	96	20	in	in	IN
cord-285806-363ivs67	96	21	a	a	DT
cord-285806-363ivs67	96	22	sepsis	sepsis	NN
cord-285806-363ivs67	96	23	infectious	infectious	JJ
cord-285806-363ivs67	96	24	model	model	NN
cord-285806-363ivs67	96	25	.	.	.
cord-285806-363ivs67	97	1	Furthermore	furthermore	RB
cord-285806-363ivs67	97	2	,	,	,
cord-285806-363ivs67	97	3	it	-PRON-	PRP
cord-285806-363ivs67	97	4	all	all	DT
cord-285806-363ivs67	97	5	points	point	VBZ
cord-285806-363ivs67	97	6	to	to	IN
cord-285806-363ivs67	97	7	the	the	DT
cord-285806-363ivs67	97	8	trans	trans	NN
cord-285806-363ivs67	97	9	-	-	JJ
cord-285806-363ivs67	97	10	signaling	signal	VBG
cord-285806-363ivs67	97	11	transduction	transduction	NN
cord-285806-363ivs67	97	12	being	be	VBG
cord-285806-363ivs67	97	13	the	the	DT
cord-285806-363ivs67	97	14	harmful	harmful	JJ
cord-285806-363ivs67	97	15	one	one	NN
cord-285806-363ivs67	97	16	(	(	-LRB-
cord-285806-363ivs67	97	17	proinflammatory	proinflammatory	JJ
cord-285806-363ivs67	97	18	response	response	NN
cord-285806-363ivs67	97	19	)	)	-RRB-
cord-285806-363ivs67	97	20	,	,	,
cord-285806-363ivs67	97	21	and	and	CC
cord-285806-363ivs67	97	22	the	the	DT
cord-285806-363ivs67	97	23	classic	classic	JJ
cord-285806-363ivs67	97	24	signaling	signaling	NN
cord-285806-363ivs67	97	25	transduction	transduction	NN
cord-285806-363ivs67	97	26	being	be	VBG
cord-285806-363ivs67	97	27	the	the	DT
cord-285806-363ivs67	97	28	protective	protective	JJ
cord-285806-363ivs67	97	29	one	one	NN
cord-285806-363ivs67	97	30	(	(	-LRB-
cord-285806-363ivs67	97	31	anti	anti	JJ
cord-285806-363ivs67	97	32	-	-	JJ
cord-285806-363ivs67	97	33	inflammatory	inflammatory	JJ
cord-285806-363ivs67	97	34	response	response	NN
cord-285806-363ivs67	97	35	)	)	-RRB-
cord-285806-363ivs67	97	36	59	59	CD
cord-285806-363ivs67	97	37	.	.	.
cord-285806-363ivs67	98	1	More	More	JJR
cord-285806-363ivs67	98	2	evidence	evidence	NN
cord-285806-363ivs67	98	3	of	of	IN
cord-285806-363ivs67	98	4	that	that	DT
cord-285806-363ivs67	98	5	in	in	IN
cord-285806-363ivs67	98	6	some	some	DT
cord-285806-363ivs67	98	7	studies	study	NNS
cord-285806-363ivs67	98	8	showing	show	VBG
cord-285806-363ivs67	98	9	that	that	IN
cord-285806-363ivs67	98	10	elevated	elevated	JJ
cord-285806-363ivs67	98	11	serum	serum	NN
cord-285806-363ivs67	98	12	levels	level	NNS
cord-285806-363ivs67	98	13	of	of	IN
cord-285806-363ivs67	98	14	IL-6	IL-6	NNP
cord-285806-363ivs67	98	15	,	,	,
cord-285806-363ivs67	98	16	which	which	WDT
cord-285806-363ivs67	98	17	are	be	VBP
cord-285806-363ivs67	98	18	a	a	DT
cord-285806-363ivs67	98	19	marker	marker	NN
cord-285806-363ivs67	98	20	of	of	IN
cord-285806-363ivs67	98	21	disease	disease	NN
cord-285806-363ivs67	98	22	severity	severity	NN
cord-285806-363ivs67	98	23	in	in	IN
cord-285806-363ivs67	98	24	the	the	DT
cord-285806-363ivs67	98	25	inflammatory	inflammatory	JJ
cord-285806-363ivs67	98	26	acute	acute	JJ
cord-285806-363ivs67	98	27	lung	lung	NN
cord-285806-363ivs67	98	28	injury	injury	NN
cord-285806-363ivs67	98	29	during	during	IN
cord-285806-363ivs67	98	30	acute	acute	JJ
cord-285806-363ivs67	98	31	pancreatitis	pancreatitis	NN
cord-285806-363ivs67	98	32	,	,	,
cord-285806-363ivs67	98	33	were	be	VBD
cord-285806-363ivs67	98	34	mediated	mediate	VBN
cord-285806-363ivs67	98	35	by	by	IN
cord-285806-363ivs67	98	36	the	the	DT
cord-285806-363ivs67	98	37	trans	trans	NN
cord-285806-363ivs67	98	38	-	-	HYPH
cord-285806-363ivs67	98	39	signaling	signal	VBG
cord-285806-363ivs67	98	40	transduction	transduction	NN
cord-285806-363ivs67	98	41	way	way	NN
cord-285806-363ivs67	98	42	,	,	,
cord-285806-363ivs67	98	43	as	as	IN
cord-285806-363ivs67	98	44	sgp130Fc	sgp130Fc	NNP
cord-285806-363ivs67	98	45	blocked	block	VBD
cord-285806-363ivs67	98	46	the	the	DT
cord-285806-363ivs67	98	47	pancreatitis	pancreatitis	NN
cord-285806-363ivs67	98	48	induced	induce	VBN
cord-285806-363ivs67	98	49	acute	acute	JJ
cord-285806-363ivs67	98	50	lung	lung	NN
cord-285806-363ivs67	98	51	injury	injury	NN
cord-285806-363ivs67	98	52	60	60	CD
cord-285806-363ivs67	98	53	.	.	.
cord-285806-363ivs67	99	1	Moreover	moreover	RB
cord-285806-363ivs67	99	2	in	in	IN
cord-285806-363ivs67	99	3	a	a	DT
cord-285806-363ivs67	99	4	mouse	mouse	NN
cord-285806-363ivs67	99	5	model	model	NN
cord-285806-363ivs67	99	6	of	of	IN
cord-285806-363ivs67	99	7	atherosclerosis	atherosclerosis	NN
cord-285806-363ivs67	99	8	sgp130Fc	sgp130Fc	NNS
cord-285806-363ivs67	99	9	showed	show	VBD
cord-285806-363ivs67	99	10	to	to	TO
cord-285806-363ivs67	99	11	reduce	reduce	VB
cord-285806-363ivs67	99	12	disease	disease	NN
cord-285806-363ivs67	99	13	and	and	CC
cord-285806-363ivs67	99	14	showed	show	VBD
cord-285806-363ivs67	99	15	significant	significant	JJ
cord-285806-363ivs67	99	16	regression	regression	NN
cord-285806-363ivs67	99	17	of	of	IN
cord-285806-363ivs67	99	18	the	the	DT
cord-285806-363ivs67	99	19	atherosclerotic	atherosclerotic	JJ
cord-285806-363ivs67	99	20	plaques	plaque	NNS
cord-285806-363ivs67	99	21	,	,	,
cord-285806-363ivs67	99	22	thus	thus	RB
cord-285806-363ivs67	99	23	underlying	underlie	VBG
cord-285806-363ivs67	99	24	the	the	DT
cord-285806-363ivs67	99	25	pro	pro	JJ
cord-285806-363ivs67	99	26	-	-	JJ
cord-285806-363ivs67	99	27	inflammatory	inflammatory	JJ
cord-285806-363ivs67	99	28	role	role	NN
cord-285806-363ivs67	99	29	of	of	IN
cord-285806-363ivs67	99	30	the	the	DT
cord-285806-363ivs67	99	31	trans	trans	NN
cord-285806-363ivs67	99	32	-	-	JJ
cord-285806-363ivs67	99	33	signaling	signal	VBG
cord-285806-363ivs67	99	34	pathway	pathway	NN
cord-285806-363ivs67	99	35	once	once	RB
cord-285806-363ivs67	99	36	more	more	JJR
cord-285806-363ivs67	99	37	61	61	CD
cord-285806-363ivs67	99	38	.	.	.
cord-285806-363ivs67	100	1	The	the	DT
cord-285806-363ivs67	100	2	sgp130Fc	sgp130fc	NN
cord-285806-363ivs67	100	3	protein	protein	NN
cord-285806-363ivs67	100	4	was	be	VBD
cord-285806-363ivs67	100	5	shown	show	VBN
cord-285806-363ivs67	100	6	not	not	RB
cord-285806-363ivs67	100	7	to	to	TO
cord-285806-363ivs67	100	8	interfere	interfere	VB
cord-285806-363ivs67	100	9	with	with	IN
cord-285806-363ivs67	100	10	IL-6	IL-6	NNP
cord-285806-363ivs67	100	11	signaling	signal	VBG
cord-285806-363ivs67	100	12	via	via	IN
cord-285806-363ivs67	100	13	the	the	DT
cord-285806-363ivs67	100	14	membranebound	membranebound	JJ
cord-285806-363ivs67	100	15	IL-6R	IL-6R	NNP
cord-285806-363ivs67	100	16	(	(	-LRB-
cord-285806-363ivs67	100	17	mIL6-R	mil6-r	NN
cord-285806-363ivs67	100	18	)	)	-RRB-
cord-285806-363ivs67	100	19	.	.	.
cord-285806-363ivs67	101	1	In	in	IN
cord-285806-363ivs67	101	2	contrast	contrast	NN
cord-285806-363ivs67	101	3	,	,	,
cord-285806-363ivs67	101	4	IL-6	IL-6	NNP
cord-285806-363ivs67	101	5	trans	trans	NNP
cord-285806-363ivs67	101	6	-	-	HYPH
cord-285806-363ivs67	101	7	signaling	signaling	NN
cord-285806-363ivs67	101	8	is	be	VBZ
cord-285806-363ivs67	101	9	completely	completely	RB
cord-285806-363ivs67	101	10	blocked	block	VBN
cord-285806-363ivs67	101	11	both	both	CC
cord-285806-363ivs67	101	12	in	in	IN
cord-285806-363ivs67	101	13	vitro	vitro	FW
cord-285806-363ivs67	101	14	and	and	CC
cord-285806-363ivs67	101	15	in	in	IN
cord-285806-363ivs67	101	16	vivo	vivo	NN
cord-285806-363ivs67	101	17	by	by	IN
cord-285806-363ivs67	101	18	the	the	DT
cord-285806-363ivs67	101	19	sgp130Fc	sgp130Fc	NNP
cord-285806-363ivs67	101	20	protein	protein	NN
cord-285806-363ivs67	101	21	46	46	CD
cord-285806-363ivs67	101	22	.	.	.
cord-285806-363ivs67	102	1	Higher	high	JJR
cord-285806-363ivs67	102	2	levels	level	NNS
cord-285806-363ivs67	102	3	of	of	IN
cord-285806-363ivs67	102	4	the	the	DT
cord-285806-363ivs67	102	5	soluble	soluble	JJ
cord-285806-363ivs67	102	6	IL-6	IL-6	NNP
cord-285806-363ivs67	102	7	receptor(sIL-6R	receptor(sIL-6R	NNS
cord-285806-363ivs67	102	8	)	)	-RRB-
cord-285806-363ivs67	102	9	are	be	VBP
cord-285806-363ivs67	102	10	usually	usually	RB
cord-285806-363ivs67	102	11	found	find	VBN
cord-285806-363ivs67	102	12	in	in	IN
cord-285806-363ivs67	102	13	chronic	chronic	JJ
cord-285806-363ivs67	102	14	inflammatory	inflammatory	JJ
cord-285806-363ivs67	102	15	diseases	disease	NNS
cord-285806-363ivs67	102	16	and	and	CC
cord-285806-363ivs67	102	17	cancer	cancer	NN
cord-285806-363ivs67	102	18	55	55	CD
cord-285806-363ivs67	102	19	,	,	,
cord-285806-363ivs67	102	20	in	in	IN
cord-285806-363ivs67	102	21	multiple	multiple	JJ
cord-285806-363ivs67	102	22	myeloma	myeloma	NN
cord-285806-363ivs67	102	23	for	for	IN
cord-285806-363ivs67	102	24	example	example	NN
cord-285806-363ivs67	102	25	high	high	JJ
cord-285806-363ivs67	102	26	sIL-6R	sil-6r	NN
cord-285806-363ivs67	102	27	levels	level	NNS
cord-285806-363ivs67	102	28	were	be	VBD
cord-285806-363ivs67	102	29	correlated	correlate	VBN
cord-285806-363ivs67	102	30	with	with	IN
cord-285806-363ivs67	102	31	poor	poor	JJ
cord-285806-363ivs67	102	32	survival	survival	NN
cord-285806-363ivs67	102	33	62	62	CD
cord-285806-363ivs67	102	34	,	,	,
cord-285806-363ivs67	102	35	sIL6R	sil6r	CD
cord-285806-363ivs67	102	36	levels	level	NNS
cord-285806-363ivs67	102	37	are	be	VBP
cord-285806-363ivs67	102	38	also	also	RB
cord-285806-363ivs67	102	39	higher	high	JJR
cord-285806-363ivs67	102	40	in	in	IN
cord-285806-363ivs67	102	41	chronic	chronic	JJ
cord-285806-363ivs67	102	42	lymphocytic	lymphocytic	JJ
cord-285806-363ivs67	102	43	leukemia	leukemia	NN
cord-285806-363ivs67	102	44	and	and	CC
cord-285806-363ivs67	102	45	lymphomas	lymphoma	NNS
cord-285806-363ivs67	102	46	63	63	CD
cord-285806-363ivs67	102	47	.	.	.
cord-285806-363ivs67	103	1	Locally	locally	RB
cord-285806-363ivs67	103	2	increased	increase	VBN
cord-285806-363ivs67	103	3	sIL-6R	sil-6r	NN
cord-285806-363ivs67	103	4	concentrations	concentration	NNS
cord-285806-363ivs67	103	5	were	be	VBD
cord-285806-363ivs67	103	6	also	also	RB
cord-285806-363ivs67	103	7	found	find	VBN
cord-285806-363ivs67	103	8	in	in	IN
cord-285806-363ivs67	103	9	the	the	DT
cord-285806-363ivs67	103	10	bronchoalveolar	bronchoalveolar	NNP
cord-285806-363ivs67	103	11	lavage	lavage	NN
cord-285806-363ivs67	103	12	fluid	fluid	NN
cord-285806-363ivs67	103	13	(	(	-LRB-
cord-285806-363ivs67	103	14	BAL	BAL	NNP
cord-285806-363ivs67	103	15	)	)	-RRB-
cord-285806-363ivs67	103	16	of	of	IN
cord-285806-363ivs67	103	17	asthmatics	asthmatic	NNS
cord-285806-363ivs67	103	18	64	64	CD
cord-285806-363ivs67	103	19	,	,	,
cord-285806-363ivs67	103	20	and	and	CC
cord-285806-363ivs67	103	21	in	in	IN
cord-285806-363ivs67	103	22	malignant	malignant	JJ
cord-285806-363ivs67	103	23	ascites	ascites	NN
cord-285806-363ivs67	103	24	from	from	IN
cord-285806-363ivs67	103	25	ovarian	ovarian	JJ
cord-285806-363ivs67	103	26	cancer	cancer	NN
cord-285806-363ivs67	103	27	patients	patient	NNS
cord-285806-363ivs67	103	28	,	,	,
cord-285806-363ivs67	103	29	where	where	WRB
cord-285806-363ivs67	103	30	it	-PRON-	PRP
cord-285806-363ivs67	103	31	was	be	VBD
cord-285806-363ivs67	103	32	associated	associate	VBN
cord-285806-363ivs67	103	33	with	with	IN
cord-285806-363ivs67	103	34	poor	poor	JJ
cord-285806-363ivs67	103	35	prognosis	prognosis	NN
cord-285806-363ivs67	103	36	65	65	CD
cord-285806-363ivs67	103	37	.	.	.
cord-285806-363ivs67	104	1	Since	since	IN
cord-285806-363ivs67	104	2	sgp130	sgp130	NNS
cord-285806-363ivs67	104	3	is	be	VBZ
cord-285806-363ivs67	104	4	expressed	express	VBN
cord-285806-363ivs67	104	5	in	in	IN
cord-285806-363ivs67	104	6	all	all	DT
cord-285806-363ivs67	104	7	cells	cell	NNS
cord-285806-363ivs67	104	8	of	of	IN
cord-285806-363ivs67	104	9	the	the	DT
cord-285806-363ivs67	104	10	human	human	JJ
cord-285806-363ivs67	104	11	body	body	NN
cord-285806-363ivs67	104	12	,	,	,
cord-285806-363ivs67	104	13	under	under	IN
cord-285806-363ivs67	104	14	normal	normal	JJ
cord-285806-363ivs67	104	15	circumstances	circumstance	NNS
cord-285806-363ivs67	104	16	it	-PRON-	PRP
cord-285806-363ivs67	104	17	is	be	VBZ
cord-285806-363ivs67	104	18	in	in	IN
cord-285806-363ivs67	104	19	molar	molar	JJ
cord-285806-363ivs67	104	20	excess	excess	NN
cord-285806-363ivs67	104	21	over	over	IN
cord-285806-363ivs67	104	22	sIL-6R	sIL-6R	NNP
cord-285806-363ivs67	104	23	,	,	,
cord-285806-363ivs67	104	24	therefore	therefore	RB
cord-285806-363ivs67	104	25	the	the	DT
cord-285806-363ivs67	104	26	concentration	concentration	NN
cord-285806-363ivs67	104	27	of	of	IN
cord-285806-363ivs67	104	28	the	the	DT
cord-285806-363ivs67	104	29	sIL-6R	sil-6r	NN
cord-285806-363ivs67	104	30	limits	limit	VBZ
cord-285806-363ivs67	104	31	the	the	DT
cord-285806-363ivs67	104	32	capacity	capacity	NN
cord-285806-363ivs67	104	33	of	of	IN
cord-285806-363ivs67	104	34	the	the	DT
cord-285806-363ivs67	104	35	sIL-6R	sIL-6R	NNP
cord-285806-363ivs67	104	36	/	/	SYM
cord-285806-363ivs67	104	37	sgp130	sgp130	NNP
cord-285806-363ivs67	104	38	complex	complex	JJ
cord-285806-363ivs67	104	39	in	in	IN
cord-285806-363ivs67	104	40	the	the	DT
cord-285806-363ivs67	104	41	blood	blood	NN
cord-285806-363ivs67	104	42	.	.	.
cord-285806-363ivs67	105	1	During	during	IN
cord-285806-363ivs67	105	2	infections	infection	NNS
cord-285806-363ivs67	105	3	and	and	CC
cord-285806-363ivs67	105	4	inflammatory	inflammatory	JJ
cord-285806-363ivs67	105	5	states	state	NNS
cord-285806-363ivs67	105	6	,	,	,
cord-285806-363ivs67	105	7	the	the	DT
cord-285806-363ivs67	105	8	concentration	concentration	NN
cord-285806-363ivs67	105	9	of	of	IN
cord-285806-363ivs67	105	10	sgp130	sgp130	NNPS
cord-285806-363ivs67	105	11	does	do	VBZ
cord-285806-363ivs67	105	12	not	not	RB
cord-285806-363ivs67	105	13	change	change	VB
cord-285806-363ivs67	105	14	,	,	,
cord-285806-363ivs67	105	15	but	but	CC
cord-285806-363ivs67	105	16	the	the	DT
cord-285806-363ivs67	105	17	concentration	concentration	NN
cord-285806-363ivs67	105	18	of	of	IN
cord-285806-363ivs67	105	19	the	the	DT
cord-285806-363ivs67	105	20	sIL-6R	sil-6r	NN
cord-285806-363ivs67	105	21	increases	increase	VBZ
cord-285806-363ivs67	105	22	up	up	IN
cord-285806-363ivs67	105	23	to	to	TO
cord-285806-363ivs67	105	24	5	5	CD
cord-285806-363ivs67	105	25	fold	fold	VB
cord-285806-363ivs67	105	26	66	66	CD
cord-285806-363ivs67	105	27	.	.	.
cord-285806-363ivs67	106	1	As	as	IN
cord-285806-363ivs67	106	2	a	a	DT
cord-285806-363ivs67	106	3	consequence	consequence	NN
cord-285806-363ivs67	106	4	,	,	,
cord-285806-363ivs67	106	5	IL-6	IL-6	NNP
cord-285806-363ivs67	106	6	and	and	CC
cord-285806-363ivs67	106	7	sIL-6R	sIL-6R	NNP
cord-285806-363ivs67	106	8	trans	trans	NNP
cord-285806-363ivs67	106	9	-	-	JJ
cord-285806-363ivs67	106	10	signaling	signal	VBG
cord-285806-363ivs67	106	11	pathway	pathway	NN
cord-285806-363ivs67	106	12	stimulate	stimulate	VBP
cord-285806-363ivs67	106	13	all	all	DT
cord-285806-363ivs67	106	14	cells	cell	NNS
cord-285806-363ivs67	106	15	,	,	,
cord-285806-363ivs67	106	16	which	which	WDT
cord-285806-363ivs67	106	17	normally	normally	RB
cord-285806-363ivs67	106	18	are	be	VBP
cord-285806-363ivs67	106	19	not	not	RB
cord-285806-363ivs67	106	20	IL-6	IL-6	NNP
cord-285806-363ivs67	106	21	target	target	NN
cord-285806-363ivs67	106	22	cells	cell	NNS
cord-285806-363ivs67	106	23	,	,	,
cord-285806-363ivs67	106	24	like	like	IN
cord-285806-363ivs67	106	25	endothelial	endothelial	JJ
cord-285806-363ivs67	106	26	cells	cell	NNS
cord-285806-363ivs67	106	27	and	and	CC
cord-285806-363ivs67	106	28	smooth	smooth	JJ
cord-285806-363ivs67	106	29	muscles	muscle	NNS
cord-285806-363ivs67	106	30	cells	cell	NNS
cord-285806-363ivs67	106	31	67	67	CD
cord-285806-363ivs67	106	32	.	.	.
cord-285806-363ivs67	107	1	Recent	recent	JJ
cord-285806-363ivs67	107	2	studies	study	NNS
cord-285806-363ivs67	107	3	about	about	IN
cord-285806-363ivs67	107	4	polymorphism	polymorphism	NN
cord-285806-363ivs67	107	5	within	within	IN
cord-285806-363ivs67	107	6	the	the	DT
cord-285806-363ivs67	107	7	IL-6R	IL-6R	NNP
cord-285806-363ivs67	107	8	genes	gene	NNS
cord-285806-363ivs67	107	9	,	,	,
cord-285806-363ivs67	107	10	showed	show	VBD
cord-285806-363ivs67	107	11	how	how	WRB
cord-285806-363ivs67	107	12	some	some	DT
cord-285806-363ivs67	107	13	IL-6	IL-6	NNP
cord-285806-363ivs67	107	14	Receptor	Receptor	NNP
cord-285806-363ivs67	107	15	variants	variant	NNS
cord-285806-363ivs67	107	16	could	could	MD
cord-285806-363ivs67	107	17	be	be	VB
cord-285806-363ivs67	107	18	a	a	DT
cord-285806-363ivs67	107	19	much	much	RB
cord-285806-363ivs67	107	20	better	well	JJR
cord-285806-363ivs67	107	21	substrate	substrate	NN
cord-285806-363ivs67	107	22	for	for	IN
cord-285806-363ivs67	107	23	the	the	DT
cord-285806-363ivs67	107	24	shedding	shedding	JJ
cord-285806-363ivs67	107	25	protease	protease	NN
cord-285806-363ivs67	107	26	ADAM17	adam17	NN
cord-285806-363ivs67	107	27	,	,	,
cord-285806-363ivs67	107	28	resulting	result	VBG
cord-285806-363ivs67	107	29	in	in	IN
cord-285806-363ivs67	107	30	a	a	DT
cord-285806-363ivs67	107	31	reduced	reduced	JJ
cord-285806-363ivs67	107	32	response	response	NN
cord-285806-363ivs67	107	33	to	to	IN
cord-285806-363ivs67	107	34	inflammation	inflammation	NN
cord-285806-363ivs67	107	35	and	and	CC
cord-285806-363ivs67	107	36	infectious	infectious	JJ
cord-285806-363ivs67	107	37	states	state	NNS
cord-285806-363ivs67	107	38	,	,	,
cord-285806-363ivs67	107	39	in	in	IN
cord-285806-363ivs67	107	40	terms	term	NNS
cord-285806-363ivs67	107	41	of	of	IN
cord-285806-363ivs67	107	42	sIL-6R	sil-6r	NN
cord-285806-363ivs67	107	43	increase	increase	NN
cord-285806-363ivs67	107	44	68	68	CD
cord-285806-363ivs67	107	45	.	.	.
cord-285806-363ivs67	108	1	Those	those	DT
cord-285806-363ivs67	108	2	individuals	individual	NNS
cord-285806-363ivs67	108	3	are	be	VBP
cord-285806-363ivs67	108	4	also	also	RB
cord-285806-363ivs67	108	5	protected	protect	VBN
cord-285806-363ivs67	108	6	from	from	IN
cord-285806-363ivs67	108	7	many	many	JJ
cord-285806-363ivs67	108	8	chronic	chronic	JJ
cord-285806-363ivs67	108	9	inflammatory	inflammatory	JJ
cord-285806-363ivs67	108	10	diseases	disease	NNS
cord-285806-363ivs67	108	11	69	69	CD
cord-285806-363ivs67	108	12	.	.	.
cord-285806-363ivs67	109	1	This	this	DT
cord-285806-363ivs67	109	2	is	be	VBZ
cord-285806-363ivs67	109	3	another	another	DT
cord-285806-363ivs67	109	4	evidence	evidence	NN
cord-285806-363ivs67	109	5	of	of	IN
cord-285806-363ivs67	109	6	the	the	DT
cord-285806-363ivs67	109	7	pro	pro	JJ
cord-285806-363ivs67	109	8	-	-	JJ
cord-285806-363ivs67	109	9	inflammatory	inflammatory	JJ
cord-285806-363ivs67	109	10	role	role	NN
cord-285806-363ivs67	109	11	of	of	IN
cord-285806-363ivs67	109	12	the	the	DT
cord-285806-363ivs67	109	13	trans	trans	NN
cord-285806-363ivs67	109	14	-	-	JJ
cord-285806-363ivs67	109	15	signaling	signal	VBG
cord-285806-363ivs67	109	16	pathway	pathway	NN
cord-285806-363ivs67	109	17	and	and	CC
cord-285806-363ivs67	109	18	it	-PRON-	PRP
cord-285806-363ivs67	109	19	could	could	MD
cord-285806-363ivs67	109	20	also	also	RB
cord-285806-363ivs67	109	21	be	be	VB
cord-285806-363ivs67	109	22	the	the	DT
cord-285806-363ivs67	109	23	explanation	explanation	NN
cord-285806-363ivs67	109	24	as	as	IN
cord-285806-363ivs67	109	25	to	to	IN
cord-285806-363ivs67	109	26	why	why	WRB
cord-285806-363ivs67	109	27	some	some	DT
cord-285806-363ivs67	109	28	patients	patient	NNS
cord-285806-363ivs67	109	29	show	show	VBP
cord-285806-363ivs67	109	30	a	a	DT
cord-285806-363ivs67	109	31	higher	high	JJR
cord-285806-363ivs67	109	32	inflammatory	inflammatory	JJ
cord-285806-363ivs67	109	33	response	response	NN
cord-285806-363ivs67	109	34	mediated	mediate	VBN
cord-285806-363ivs67	109	35	by	by	IN
cord-285806-363ivs67	109	36	IL-6	IL-6	NNP
cord-285806-363ivs67	109	37	,	,	,
cord-285806-363ivs67	109	38	similarly	similarly	RB
cord-285806-363ivs67	109	39	to	to	IN
cord-285806-363ivs67	109	40	what	what	WP
cord-285806-363ivs67	109	41	is	be	VBZ
cord-285806-363ivs67	109	42	happening	happen	VBG
cord-285806-363ivs67	109	43	with	with	IN
cord-285806-363ivs67	109	44	SARS	SARS	NNP
cord-285806-363ivs67	109	45	-	-	HYPH
cord-285806-363ivs67	109	46	CoV-2	CoV-2	NNP
cord-285806-363ivs67	109	47	infection	infection	NN
cord-285806-363ivs67	109	48	.	.	.
cord-285806-363ivs67	110	1	The	the	DT
cord-285806-363ivs67	110	2	essential	essential	JJ
cord-285806-363ivs67	110	3	role	role	NN
cord-285806-363ivs67	110	4	of	of	IN
cord-285806-363ivs67	110	5	IL-6	IL-6	NNP
cord-285806-363ivs67	110	6	in	in	IN
cord-285806-363ivs67	110	7	fighting	fighting	NN
cord-285806-363ivs67	110	8	and	and	CC
cord-285806-363ivs67	110	9	clearing	clearing	NN
cord-285806-363ivs67	110	10	influenza	influenza	NN
cord-285806-363ivs67	110	11	infection	infection	NN
cord-285806-363ivs67	110	12	has	have	VBZ
cord-285806-363ivs67	110	13	already	already	RB
cord-285806-363ivs67	110	14	been	be	VBN
cord-285806-363ivs67	110	15	discussed	discuss	VBN
cord-285806-363ivs67	110	16	above	above	IN
cord-285806-363ivs67	110	17	19	19	CD
cord-285806-363ivs67	110	18	.	.	.
cord-285806-363ivs67	111	1	This	this	DT
cord-285806-363ivs67	111	2	protective	protective	JJ
cord-285806-363ivs67	111	3	role	role	NN
cord-285806-363ivs67	111	4	could	could	MD
cord-285806-363ivs67	111	5	be	be	VB
cord-285806-363ivs67	111	6	mediated	mediate	VBN
cord-285806-363ivs67	111	7	by	by	IN
cord-285806-363ivs67	111	8	IL-6	IL-6	NNP
cord-285806-363ivs67	111	9	classic	classic	JJ
cord-285806-363ivs67	111	10	signaling	signaling	NN
cord-285806-363ivs67	111	11	.	.	.
cord-285806-363ivs67	112	1	This	this	DT
cord-285806-363ivs67	112	2	also	also	RB
cord-285806-363ivs67	112	3	happens	happen	VBZ
cord-285806-363ivs67	112	4	for	for	IN
cord-285806-363ivs67	112	5	other	other	JJ
cord-285806-363ivs67	112	6	infections	infection	NNS
cord-285806-363ivs67	112	7	like	like	IN
cord-285806-363ivs67	112	8	Listeria	Listeria	NNP
cord-285806-363ivs67	112	9	and	and	CC
cord-285806-363ivs67	112	10	mycobacteria	mycobacterium	NNS
cord-285806-363ivs67	112	11	infections	infection	NNS
cord-285806-363ivs67	112	12	,	,	,
cord-285806-363ivs67	112	13	where	where	WRB
cord-285806-363ivs67	112	14	IL-6	IL-6	NNP
cord-285806-363ivs67	112	15	classic	classic	JJ
cord-285806-363ivs67	112	16	signaling	signal	VBG
cord-285806-363ivs67	112	17	via	via	IN
cord-285806-363ivs67	112	18	the	the	DT
cord-285806-363ivs67	112	19	membrane	membrane	NN
cord-285806-363ivs67	112	20	bound	bind	VBN
cord-285806-363ivs67	112	21	IL-6R	IL-6R	NNP
cord-285806-363ivs67	112	22	is	be	VBZ
cord-285806-363ivs67	112	23	responsible	responsible	JJ
cord-285806-363ivs67	112	24	for	for	IN
cord-285806-363ivs67	112	25	the	the	DT
cord-285806-363ivs67	112	26	defense	defense	NN
cord-285806-363ivs67	112	27	of	of	IN
cord-285806-363ivs67	112	28	the	the	DT
cord-285806-363ivs67	112	29	body	body	NN
cord-285806-363ivs67	112	30	against	against	IN
cord-285806-363ivs67	112	31	these	these	DT
cord-285806-363ivs67	112	32	pathogens	pathogen	NNS
cord-285806-363ivs67	112	33	.	.	.
cord-285806-363ivs67	113	1	Furthermore	furthermore	RB
cord-285806-363ivs67	113	2	this	this	DT
cord-285806-363ivs67	113	3	defense	defense	NN
cord-285806-363ivs67	113	4	is	be	VBZ
cord-285806-363ivs67	113	5	not	not	RB
cord-285806-363ivs67	113	6	affected	affect	VBN
cord-285806-363ivs67	113	7	by	by	IN
cord-285806-363ivs67	113	8	the	the	DT
cord-285806-363ivs67	113	9	selective	selective	JJ
cord-285806-363ivs67	113	10	blockade	blockade	NN
cord-285806-363ivs67	113	11	of	of	IN
cord-285806-363ivs67	113	12	IL-6	IL-6	NNP
cord-285806-363ivs67	113	13	trans	trans	NNP
cord-285806-363ivs67	113	14	-	-	JJ
cord-285806-363ivs67	113	15	signaling	signal	VBG
cord-285806-363ivs67	113	16	70	70	CD
cord-285806-363ivs67	113	17	,	,	,
cord-285806-363ivs67	113	18	71	71	CD
cord-285806-363ivs67	113	19	.	.	.
cord-285806-363ivs67	114	1	In	in	IN
cord-285806-363ivs67	114	2	the	the	DT
cord-285806-363ivs67	114	3	animal	animal	NN
cord-285806-363ivs67	114	4	model	model	NN
cord-285806-363ivs67	114	5	of	of	IN
cord-285806-363ivs67	114	6	listeriosis	listeriosis	NN
cord-285806-363ivs67	114	7	global	global	JJ
cord-285806-363ivs67	114	8	blockade	blockade	NN
cord-285806-363ivs67	114	9	of	of	IN
cord-285806-363ivs67	114	10	IL-6	IL-6	NNP
cord-285806-363ivs67	114	11	led	lead	VBD
cord-285806-363ivs67	114	12	to	to	IN
cord-285806-363ivs67	114	13	a	a	DT
cord-285806-363ivs67	114	14	dramatic	dramatic	JJ
cord-285806-363ivs67	114	15	increase	increase	NN
cord-285806-363ivs67	114	16	in	in	IN
cord-285806-363ivs67	114	17	bacterial	bacterial	JJ
cord-285806-363ivs67	114	18	titers	titer	NNS
cord-285806-363ivs67	114	19	in	in	IN
cord-285806-363ivs67	114	20	spleen	spleen	NNS
cord-285806-363ivs67	114	21	and	and	CC
cord-285806-363ivs67	114	22	liver	liver	NN
cord-285806-363ivs67	114	23	.	.	.
cord-285806-363ivs67	115	1	In	in	IN
cord-285806-363ivs67	115	2	contrast	contrast	NN
cord-285806-363ivs67	115	3	,	,	,
cord-285806-363ivs67	115	4	selective	selective	JJ
cord-285806-363ivs67	115	5	blockade	blockade	NN
cord-285806-363ivs67	115	6	of	of	IN
cord-285806-363ivs67	115	7	IL-6	IL-6	NNP
cord-285806-363ivs67	115	8	trans	trans	NNP
cord-285806-363ivs67	115	9	-	-	NN
cord-285806-363ivs67	115	10	signaling	signal	VBG
cord-285806-363ivs67	115	11	with	with	IN
cord-285806-363ivs67	115	12	the	the	DT
cord-285806-363ivs67	115	13	sgp130Fc	sgp130fc	XX
cord-285806-363ivs67	115	14	protein	protein	NN
cord-285806-363ivs67	115	15	did	do	VBD
cord-285806-363ivs67	115	16	not	not	RB
cord-285806-363ivs67	115	17	result	result	VB
cord-285806-363ivs67	115	18	in	in	IN
cord-285806-363ivs67	115	19	increased	increase	VBN
cord-285806-363ivs67	115	20	bacterial	bacterial	JJ
cord-285806-363ivs67	115	21	titers	titer	NNS
cord-285806-363ivs67	115	22	,	,	,
cord-285806-363ivs67	115	23	and	and	CC
cord-285806-363ivs67	115	24	thus	thus	RB
cord-285806-363ivs67	115	25	was	be	VBD
cord-285806-363ivs67	115	26	concluded	conclude	VBN
cord-285806-363ivs67	115	27	that	that	IN
cord-285806-363ivs67	115	28	the	the	DT
cord-285806-363ivs67	115	29	classic	classic	JJ
cord-285806-363ivs67	115	30	signaling	signaling	NN
cord-285806-363ivs67	115	31	was	be	VBD
cord-285806-363ivs67	115	32	involved	involve	VBN
cord-285806-363ivs67	115	33	in	in	IN
cord-285806-363ivs67	115	34	the	the	DT
cord-285806-363ivs67	115	35	protection	protection	NN
cord-285806-363ivs67	115	36	of	of	IN
cord-285806-363ivs67	115	37	the	the	DT
cord-285806-363ivs67	115	38	body	body	NN
cord-285806-363ivs67	115	39	from	from	IN
cord-285806-363ivs67	115	40	bacterial	bacterial	JJ
cord-285806-363ivs67	115	41	infection	infection	NN
cord-285806-363ivs67	115	42	71	71	CD
cord-285806-363ivs67	115	43	.	.	.
cord-285806-363ivs67	116	1	This	this	DT
cord-285806-363ivs67	116	2	shows	show	VBZ
cord-285806-363ivs67	116	3	the	the	DT
cord-285806-363ivs67	116	4	possibility	possibility	NN
cord-285806-363ivs67	116	5	to	to	TO
cord-285806-363ivs67	116	6	use	use	VB
cord-285806-363ivs67	116	7	the	the	DT
cord-285806-363ivs67	116	8	sgp130Fc	sgp130fc	XX
cord-285806-363ivs67	116	9	protein	protein	NN
cord-285806-363ivs67	116	10	as	as	IN
cord-285806-363ivs67	116	11	a	a	DT
cord-285806-363ivs67	116	12	potential	potential	JJ
cord-285806-363ivs67	116	13	inhibitor	inhibitor	NN
cord-285806-363ivs67	116	14	of	of	IN
cord-285806-363ivs67	116	15	the	the	DT
cord-285806-363ivs67	116	16	IL-6	IL-6	NNP
cord-285806-363ivs67	116	17	pathway	pathway	NN
cord-285806-363ivs67	116	18	in	in	IN
cord-285806-363ivs67	116	19	COVID-19	COVID-19	NNP
cord-285806-363ivs67	116	20	patients	patient	NNS
cord-285806-363ivs67	116	21	,	,	,
cord-285806-363ivs67	116	22	since	since	IN
cord-285806-363ivs67	116	23	it	-PRON-	PRP
cord-285806-363ivs67	116	24	could	could	MD
cord-285806-363ivs67	116	25	preserve	preserve	VB
cord-285806-363ivs67	116	26	the	the	DT
cord-285806-363ivs67	116	27	regenerative	regenerative	JJ
cord-285806-363ivs67	116	28	and	and	CC
cord-285806-363ivs67	116	29	anti	anti	JJ
cord-285806-363ivs67	116	30	-	-	JJ
cord-285806-363ivs67	116	31	inflammatory	inflammatory	JJ
cord-285806-363ivs67	116	32	properties	property	NNS
cord-285806-363ivs67	116	33	of	of	IN
cord-285806-363ivs67	116	34	the	the	DT
cord-285806-363ivs67	116	35	IL-6	IL-6	NNP
cord-285806-363ivs67	116	36	classic	classic	JJ
cord-285806-363ivs67	116	37	pathway	pathway	NN
cord-285806-363ivs67	116	38	,	,	,
cord-285806-363ivs67	116	39	and	and	CC
cord-285806-363ivs67	116	40	block	block	VB
cord-285806-363ivs67	116	41	the	the	DT
cord-285806-363ivs67	116	42	pro	pro	JJ
cord-285806-363ivs67	116	43	-	-	JJ
cord-285806-363ivs67	116	44	inflammatory	inflammatory	JJ
cord-285806-363ivs67	116	45	actions	action	NNS
cord-285806-363ivs67	116	46	mediated	mediate	VBN
cord-285806-363ivs67	116	47	by	by	IN
cord-285806-363ivs67	116	48	trans	trans	NNP
cord-285806-363ivs67	116	49	-	-	JJ
cord-285806-363ivs67	116	50	signaling	signal	VBG
cord-285806-363ivs67	116	51	pathway	pathway	NN
cord-285806-363ivs67	116	52	46	46	CD
cord-285806-363ivs67	116	53	.	.	.
cord-285806-363ivs67	117	1	It	-PRON-	PRP
cord-285806-363ivs67	117	2	has	have	VBZ
cord-285806-363ivs67	117	3	been	be	VBN
cord-285806-363ivs67	117	4	shown	show	VBN
cord-285806-363ivs67	117	5	that	that	IN
cord-285806-363ivs67	117	6	the	the	DT
cord-285806-363ivs67	117	7	blockade	blockade	NN
cord-285806-363ivs67	117	8	of	of	IN
cord-285806-363ivs67	117	9	IL-6	IL-6	NNP
cord-285806-363ivs67	117	10	trans	trans	NNP
cord-285806-363ivs67	117	11	-	-	NN
cord-285806-363ivs67	117	12	signaling	signal	VBG
cord-285806-363ivs67	117	13	using	use	VBG
cord-285806-363ivs67	117	14	sgp130Fc	sgp130Fc	NNP
cord-285806-363ivs67	117	15	was	be	VBD
cord-285806-363ivs67	117	16	as	as	RB
cord-285806-363ivs67	117	17	efficient	efficient	JJ
cord-285806-363ivs67	117	18	as	as	IN
cord-285806-363ivs67	117	19	the	the	DT
cord-285806-363ivs67	117	20	global	global	JJ
cord-285806-363ivs67	117	21	blockade	blockade	NN
cord-285806-363ivs67	117	22	of	of	IN
cord-285806-363ivs67	117	23	IL-6	IL-6	NNP
cord-285806-363ivs67	117	24	classic	classic	JJ
cord-285806-363ivs67	117	25	and	and	CC
cord-285806-363ivs67	117	26	trans	trans	JJ
cord-285806-363ivs67	117	27	-	-	NN
cord-285806-363ivs67	117	28	signaling	signal	VBG
cord-285806-363ivs67	117	29	using	use	VBG
cord-285806-363ivs67	117	30	specific	specific	JJ
cord-285806-363ivs67	117	31	monoclonal	monoclonal	JJ
cord-285806-363ivs67	117	32	antibodies	antibody	NNS
cord-285806-363ivs67	117	33	72	72	CD
cord-285806-363ivs67	117	34	.	.	.
cord-285806-363ivs67	118	1	SGP130Fc	sgp130fc	NN
cord-285806-363ivs67	118	2	is	be	VBZ
cord-285806-363ivs67	118	3	mainly	mainly	RB
cord-285806-363ivs67	118	4	used	use	VBN
cord-285806-363ivs67	118	5	in	in	IN
cord-285806-363ivs67	118	6	chronic	chronic	JJ
cord-285806-363ivs67	118	7	inflammatory	inflammatory	JJ
cord-285806-363ivs67	118	8	diseases	disease	NNS
cord-285806-363ivs67	118	9	(	(	-LRB-
cord-285806-363ivs67	118	10	such	such	JJ
cord-285806-363ivs67	118	11	as	as	IN
cord-285806-363ivs67	118	12	intestinal	intestinal	JJ
cord-285806-363ivs67	118	13	inflammation	inflammation	NN
cord-285806-363ivs67	118	14	,	,	,
cord-285806-363ivs67	118	15	rheumatoid	rheumatoid	NN
cord-285806-363ivs67	118	16	arthritis	arthritis	NN
cord-285806-363ivs67	118	17	,	,	,
cord-285806-363ivs67	118	18	lupus	lupus	NN
cord-285806-363ivs67	118	19	erythematosus	erythematosus	NN
cord-285806-363ivs67	118	20	,	,	,
cord-285806-363ivs67	118	21	neuroinflammation	neuroinflammation	NN
cord-285806-363ivs67	118	22	and	and	CC
cord-285806-363ivs67	118	23	cancer	cancer	NN
cord-285806-363ivs67	118	24	51	51	CD
cord-285806-363ivs67	118	25	)	)	-RRB-
cord-285806-363ivs67	118	26	,	,	,
cord-285806-363ivs67	118	27	but	but	CC
cord-285806-363ivs67	118	28	it	-PRON-	PRP
cord-285806-363ivs67	118	29	has	have	VBZ
cord-285806-363ivs67	118	30	shown	show	VBN
cord-285806-363ivs67	118	31	its	-PRON-	PRP$
cord-285806-363ivs67	118	32	efficacy	efficacy	NN
cord-285806-363ivs67	118	33	also	also	RB
cord-285806-363ivs67	118	34	in	in	IN
cord-285806-363ivs67	118	35	acute	acute	JJ
cord-285806-363ivs67	118	36	inflammation	inflammation	NN
cord-285806-363ivs67	118	37	57	57	CD
cord-285806-363ivs67	118	38	rate	rate	NN
cord-285806-363ivs67	118	39	.	.	.
cord-285806-363ivs67	119	1	This	this	DT
cord-285806-363ivs67	119	2	demonstrate	demonstrate	VBP
cord-285806-363ivs67	119	3	that	that	IN
cord-285806-363ivs67	119	4	trans	trans	NN
cord-285806-363ivs67	119	5	-	-	NN
cord-285806-363ivs67	119	6	signaling	signaling	NN
cord-285806-363ivs67	119	7	,	,	,
cord-285806-363ivs67	119	8	rather	rather	RB
cord-285806-363ivs67	119	9	than	than	IN
cord-285806-363ivs67	119	10	classic	classic	JJ
cord-285806-363ivs67	119	11	signaling	signaling	NN
cord-285806-363ivs67	119	12	,	,	,
cord-285806-363ivs67	119	13	contributes	contribute	VBZ
cord-285806-363ivs67	119	14	to	to	IN
cord-285806-363ivs67	119	15	malaria	malaria	NN
cord-285806-363ivs67	119	16	lethality	lethality	NN
cord-285806-363ivs67	119	17	in	in	IN
cord-285806-363ivs67	119	18	mice	mouse	NNS
cord-285806-363ivs67	119	19	74	74	CD
cord-285806-363ivs67	119	20	.	.	.
cord-285806-363ivs67	120	1	IL-6	IL-6	NNP
cord-285806-363ivs67	120	2	trans	trans	NNP
cord-285806-363ivs67	120	3	-	-	HYPH
cord-285806-363ivs67	120	4	signaling	signaling	NN
cord-285806-363ivs67	120	5	is	be	VBZ
cord-285806-363ivs67	120	6	also	also	RB
cord-285806-363ivs67	120	7	involved	involve	VBN
cord-285806-363ivs67	120	8	in	in	IN
cord-285806-363ivs67	120	9	the	the	DT
cord-285806-363ivs67	120	10	infiltration	infiltration	NN
cord-285806-363ivs67	120	11	of	of	IN
cord-285806-363ivs67	120	12	granulocytes	granulocyte	NNS
cord-285806-363ivs67	120	13	and	and	CC
cord-285806-363ivs67	120	14	macrophages	macrophage	NNS
cord-285806-363ivs67	120	15	during	during	IN
cord-285806-363ivs67	120	16	the	the	DT
cord-285806-363ivs67	120	17	late	late	JJ
cord-285806-363ivs67	120	18	phase	phase	NN
cord-285806-363ivs67	120	19	of	of	IN
cord-285806-363ivs67	120	20	an	an	DT
cord-285806-363ivs67	120	21	acute	acute	JJ
cord-285806-363ivs67	120	22	inflammation	inflammation	NN
cord-285806-363ivs67	120	23	,	,	,
cord-285806-363ivs67	120	24	and	and	CC
cord-285806-363ivs67	120	25	this	this	DT
cord-285806-363ivs67	120	26	happens	happen	VBZ
cord-285806-363ivs67	120	27	when	when	WRB
cord-285806-363ivs67	120	28	the	the	DT
cord-285806-363ivs67	120	29	trans	trans	NN
cord-285806-363ivs67	120	30	-	-	JJ
cord-285806-363ivs67	120	31	signaling	signal	VBG
cord-285806-363ivs67	120	32	triggers	trigger	VBZ
cord-285806-363ivs67	120	33	the	the	DT
cord-285806-363ivs67	120	34	secretion	secretion	NN
cord-285806-363ivs67	120	35	of	of	IN
cord-285806-363ivs67	120	36	chemokine	chemokine	NN
cord-285806-363ivs67	120	37	MCP-1	MCP-1	NNP
cord-285806-363ivs67	120	38	in	in	IN
cord-285806-363ivs67	120	39	endothelial	endothelial	JJ
cord-285806-363ivs67	120	40	cells	cell	NNS
cord-285806-363ivs67	120	41	57	57	CD
cord-285806-363ivs67	120	42	 	 	_SP
cord-285806-363ivs67	120	43	(	(	-LRB-
cord-285806-363ivs67	120	44	mIL6-R	mil6-r	NN
cord-285806-363ivs67	120	45	)	)	-RRB-
cord-285806-363ivs67	120	46	and	and	CC
cord-285806-363ivs67	120	47	are	be	VBP
cord-285806-363ivs67	120	48	then	then	RB
cord-285806-363ivs67	120	49	unresponsive	unresponsive	JJ
cord-285806-363ivs67	120	50	to	to	IN
cord-285806-363ivs67	120	51	IL-6	IL-6	NNP
cord-285806-363ivs67	120	52	classic	classic	RB
cord-285806-363ivs67	120	53	-	-	HYPH
cord-285806-363ivs67	120	54	signaling	signal	VBG
cord-285806-363ivs67	120	55	75	75	CD
cord-285806-363ivs67	120	56	.	.	.
cord-285806-363ivs67	121	1	The	the	DT
cord-285806-363ivs67	121	2	infiltration	infiltration	NN
cord-285806-363ivs67	121	3	of	of	IN
cord-285806-363ivs67	121	4	granulocytes	granulocyte	NNS
cord-285806-363ivs67	121	5	and	and	CC
cord-285806-363ivs67	121	6	macrophages	macrophage	NNS
cord-285806-363ivs67	121	7	has	have	VBZ
cord-285806-363ivs67	121	8	been	be	VBN
cord-285806-363ivs67	121	9	described	describe	VBN
cord-285806-363ivs67	121	10	as	as	IN
cord-285806-363ivs67	121	11	the	the	DT
cord-285806-363ivs67	121	12	possible	possible	JJ
cord-285806-363ivs67	121	13	cause	cause	NN
cord-285806-363ivs67	121	14	of	of	IN
cord-285806-363ivs67	121	15	tissue	tissue	NN
cord-285806-363ivs67	121	16	damage	damage	NN
cord-285806-363ivs67	121	17	in	in	IN
cord-285806-363ivs67	121	18	the	the	DT
cord-285806-363ivs67	121	19	acute	acute	JJ
cord-285806-363ivs67	121	20	lung	lung	NN
cord-285806-363ivs67	121	21	injury	injury	NN
cord-285806-363ivs67	121	22	,	,	,
cord-285806-363ivs67	121	23	which	which	WDT
cord-285806-363ivs67	121	24	is	be	VBZ
cord-285806-363ivs67	121	25	a	a	DT
cord-285806-363ivs67	121	26	severe	severe	JJ
cord-285806-363ivs67	121	27	complication	complication	NN
cord-285806-363ivs67	121	28	of	of	IN
cord-285806-363ivs67	121	29	severe	severe	JJ
cord-285806-363ivs67	121	30	acute	acute	JJ
cord-285806-363ivs67	121	31	pancreatitis	pancreatitis	NN
cord-285806-363ivs67	121	32	60	60	CD
cord-285806-363ivs67	121	33	.	.	.
cord-285806-363ivs67	122	1	From	from	IN
cord-285806-363ivs67	122	2	these	these	DT
cord-285806-363ivs67	122	3	data	datum	NNS
cord-285806-363ivs67	122	4	can	can	MD
cord-285806-363ivs67	122	5	be	be	VB
cord-285806-363ivs67	122	6	concluded	conclude	VBN
cord-285806-363ivs67	122	7	that	that	IN
cord-285806-363ivs67	122	8	IL-6	IL-6	NNP
cord-285806-363ivs67	122	9	classic	classic	JJ
cord-285806-363ivs67	122	10	signaling	signaling	NN
cord-285806-363ivs67	122	11	via	via	IN
cord-285806-363ivs67	122	12	the	the	DT
cord-285806-363ivs67	122	13	membrane	membrane	NN
cord-285806-363ivs67	122	14	bound	bind	VBN
cord-285806-363ivs67	122	15	IL-6R	IL-6R	NNP
cord-285806-363ivs67	122	16	is	be	VBZ
cord-285806-363ivs67	122	17	antiinflammatory	antiinflammatory	JJ
cord-285806-363ivs67	122	18	and	and	CC
cord-285806-363ivs67	122	19	protective	protective	JJ
cord-285806-363ivs67	122	20	,	,	,
cord-285806-363ivs67	122	21	mainly	mainly	RB
cord-285806-363ivs67	122	22	via	via	IN
cord-285806-363ivs67	122	23	stimulation	stimulation	NN
cord-285806-363ivs67	122	24	of	of	IN
cord-285806-363ivs67	122	25	intestinal	intestinal	JJ
cord-285806-363ivs67	122	26	regeneration	regeneration	NN
cord-285806-363ivs67	122	27	,	,	,
cord-285806-363ivs67	122	28	inhibition	inhibition	NN
cord-285806-363ivs67	122	29	of	of	IN
cord-285806-363ivs67	122	30	epithelial	epithelial	JJ
cord-285806-363ivs67	122	31	cell	cell	NN
cord-285806-363ivs67	122	32	apoptosis	apoptosis	NN
cord-285806-363ivs67	122	33	and	and	CC
cord-285806-363ivs67	122	34	defense	defense	NN
cord-285806-363ivs67	122	35	against	against	IN
cord-285806-363ivs67	122	36	infections	infection	NNS
cord-285806-363ivs67	122	37	46	46	CD
cord-285806-363ivs67	122	38	.	.	.
cord-285806-363ivs67	123	1	In	in	IN
cord-285806-363ivs67	123	2	contrast	contrast	NN
cord-285806-363ivs67	123	3	,	,	,
cord-285806-363ivs67	123	4	trans	trans	NNP
cord-285806-363ivs67	123	5	-	-	NN
cord-285806-363ivs67	123	6	signaling	signal	VBG
cord-285806-363ivs67	123	7	via	via	IN
cord-285806-363ivs67	123	8	the	the	DT
cord-285806-363ivs67	123	9	sIL6-R	sil6-r	NN
cord-285806-363ivs67	123	10	is	be	VBZ
cord-285806-363ivs67	123	11	believed	believe	VBN
cord-285806-363ivs67	123	12	to	to	TO
cord-285806-363ivs67	123	13	act	act	VB
cord-285806-363ivs67	123	14	in	in	IN
cord-285806-363ivs67	123	15	a	a	DT
cord-285806-363ivs67	123	16	rather	rather	RB
cord-285806-363ivs67	123	17	pro	pro	JJ
cord-285806-363ivs67	123	18	-	-	JJ
cord-285806-363ivs67	123	19	inflammatory	inflammatory	JJ
cord-285806-363ivs67	123	20	way	way	NN
cord-285806-363ivs67	123	21	via	via	IN
cord-285806-363ivs67	123	22	recruitment	recruitment	NN
cord-285806-363ivs67	123	23	of	of	IN
cord-285806-363ivs67	123	24	mononuclear	mononuclear	JJ
cord-285806-363ivs67	123	25	cells	cell	NNS
cord-285806-363ivs67	123	26	,	,	,
cord-285806-363ivs67	123	27	inhibition	inhibition	NN
cord-285806-363ivs67	123	28	of	of	IN
cord-285806-363ivs67	123	29	T	t	NN
cord-285806-363ivs67	123	30	-	-	HYPH
cord-285806-363ivs67	123	31	cell	cell	NN
cord-285806-363ivs67	123	32	apoptosis	apoptosis	NN
cord-285806-363ivs67	123	33	,	,	,
cord-285806-363ivs67	123	34	and	and	CC
cord-285806-363ivs67	123	35	inhibition	inhibition	NN
cord-285806-363ivs67	123	36	of	of	IN
cord-285806-363ivs67	123	37	regulatory	regulatory	JJ
cord-285806-363ivs67	123	38	T	t	NN
cord-285806-363ivs67	123	39	-	-	HYPH
cord-285806-363ivs67	123	40	cells	cell	NNS
cord-285806-363ivs67	123	41	differentiation	differentiation	NN
cord-285806-363ivs67	123	42	46	46	CD
cord-285806-363ivs67	123	43	.	.	.
cord-285806-363ivs67	124	1	Interestingly	interestingly	RB
cord-285806-363ivs67	124	2	,	,	,
cord-285806-363ivs67	124	3	clinical	clinical	JJ
cord-285806-363ivs67	124	4	pathological	pathological	JJ
cord-285806-363ivs67	124	5	analysis	analysis	NN
cord-285806-363ivs67	124	6	of	of	IN
cord-285806-363ivs67	125	1	COVID-19	COVID-19	NNP
cord-285806-363ivs67	125	2	biopsy	biopsy	NNP
cord-285806-363ivs67	125	3	samples	sample	NNS
cord-285806-363ivs67	125	4	confirmed	confirm	VBD
cord-285806-363ivs67	125	5	interstitial	interstitial	JJ
cord-285806-363ivs67	125	6	mononuclear	mononuclear	JJ
cord-285806-363ivs67	125	7	inflammatory	inflammatory	JJ
cord-285806-363ivs67	125	8	infiltrates	infiltrate	NNS
cord-285806-363ivs67	125	9	in	in	IN
cord-285806-363ivs67	125	10	lung	lung	NN
cord-285806-363ivs67	125	11	tissues	tissue	NNS
cord-285806-363ivs67	125	12	,	,	,
cord-285806-363ivs67	125	13	the	the	DT
cord-285806-363ivs67	125	14	same	same	JJ
cord-285806-363ivs67	125	15	type	type	NN
cord-285806-363ivs67	125	16	of	of	IN
cord-285806-363ivs67	125	17	cells	cell	NNS
cord-285806-363ivs67	125	18	promoted	promote	VBN
cord-285806-363ivs67	125	19	by	by	IN
cord-285806-363ivs67	125	20	IL-6	IL-6	NNP
cord-285806-363ivs67	125	21	trans	trans	NNP
cord-285806-363ivs67	125	22	-	-	HYPH
cord-285806-363ivs67	125	23	signaling	signal	VBG
cord-285806-363ivs67	125	24	76	76	CD
cord-285806-363ivs67	125	25	,	,	,
cord-285806-363ivs67	125	26	therefore	therefore	RB
cord-285806-363ivs67	125	27	suggesting	suggest	VBG
cord-285806-363ivs67	125	28	a	a	DT
cord-285806-363ivs67	125	29	possible	possible	JJ
cord-285806-363ivs67	125	30	involvement	involvement	NN
cord-285806-363ivs67	125	31	of	of	IN
cord-285806-363ivs67	125	32	trans	trans	NN
cord-285806-363ivs67	125	33	-	-	JJ
cord-285806-363ivs67	125	34	signaling	signal	VBG
cord-285806-363ivs67	125	35	pathway	pathway	NN
cord-285806-363ivs67	125	36	of	of	IN
cord-285806-363ivs67	125	37	IL-6	IL-6	NNP
cord-285806-363ivs67	125	38	in	in	IN
cord-285806-363ivs67	125	39	COVID-19	COVID-19	NNP
cord-285806-363ivs67	125	40	patients	patient	NNS
cord-285806-363ivs67	125	41	with	with	IN
cord-285806-363ivs67	125	42	ARDS	ARDS	NNP
cord-285806-363ivs67	125	43	.	.	.
cord-285806-363ivs67	126	1	Moreover	moreover	RB
cord-285806-363ivs67	126	2	,	,	,
cord-285806-363ivs67	126	3	IL-6	IL-6	NNP
cord-285806-363ivs67	126	4	production	production	NN
cord-285806-363ivs67	126	5	sustained	sustain	VBN
cord-285806-363ivs67	126	6	by	by	IN
cord-285806-363ivs67	126	7	circulating	circulate	VBG
cord-285806-363ivs67	126	8	monocytes	monocyte	NNS
cord-285806-363ivs67	126	9	in	in	IN
cord-285806-363ivs67	126	10	COVID-19	COVID-19	NNP
cord-285806-363ivs67	126	11	is	be	VBZ
cord-285806-363ivs67	126	12	a	a	DT
cord-285806-363ivs67	126	13	different	different	JJ
cord-285806-363ivs67	126	14	pathway	pathway	NN
cord-285806-363ivs67	126	15	from	from	IN
cord-285806-363ivs67	126	16	the	the	DT
cord-285806-363ivs67	126	17	one	one	CD
cord-285806-363ivs67	126	18	found	find	VBN
cord-285806-363ivs67	126	19	in	in	IN
cord-285806-363ivs67	126	20	influenza	influenza	NN
cord-285806-363ivs67	126	21	infection	infection	NN
cord-285806-363ivs67	126	22	,	,	,
cord-285806-363ivs67	126	23	proof	proof	NN
cord-285806-363ivs67	126	24	of	of	IN
cord-285806-363ivs67	126	25	that	that	DT
cord-285806-363ivs67	126	26	is	be	VBZ
cord-285806-363ivs67	126	27	Tocilizumab	Tocilizumab	NNP
cord-285806-363ivs67	126	28	partially	partially	RB
cord-285806-363ivs67	126	29	rescuing	rescue	VBG
cord-285806-363ivs67	126	30	the	the	DT
cord-285806-363ivs67	126	31	immune	immune	JJ
cord-285806-363ivs67	126	32	dysregulation	dysregulation	NN
cord-285806-363ivs67	126	33	drive	drive	NN
cord-285806-363ivs67	126	34	by	by	IN
cord-285806-363ivs67	126	35	SARS	SARS	NNP
cord-285806-363ivs67	126	36	-	-	HYPH
cord-285806-363ivs67	126	37	CoV-2	CoV-2	NNP
cord-285806-363ivs67	126	38	27	27	CD
cord-285806-363ivs67	126	39	.	.	.
cord-285806-363ivs67	127	1	To	to	IN
cord-285806-363ivs67	127	2	the	the	DT
cord-285806-363ivs67	127	3	author	author	NN
cord-285806-363ivs67	127	4	's	's	POS
cord-285806-363ivs67	127	5	knowledge	knowledge	NN
cord-285806-363ivs67	127	6	sgp130Fc	sgp130Fc	NNP
cord-285806-363ivs67	127	7	has	have	VBZ
cord-285806-363ivs67	127	8	not	not	RB
cord-285806-363ivs67	127	9	been	be	VBN
cord-285806-363ivs67	127	10	tested	test	VBN
cord-285806-363ivs67	127	11	in	in	IN
cord-285806-363ivs67	127	12	COVID-19	covid-19	JJ
cord-285806-363ivs67	127	13	patients	patient	NNS
cord-285806-363ivs67	127	14	yet	yet	RB
cord-285806-363ivs67	127	15	,	,	,
cord-285806-363ivs67	127	16	thus	thus	RB
cord-285806-363ivs67	127	17	the	the	DT
cord-285806-363ivs67	127	18	author	author	NN
cord-285806-363ivs67	127	19	suggests	suggest	VBZ
cord-285806-363ivs67	127	20	its	-PRON-	PRP$
cord-285806-363ivs67	127	21	possible	possible	JJ
cord-285806-363ivs67	127	22	use	use	NN
cord-285806-363ivs67	127	23	against	against	IN
cord-285806-363ivs67	127	24	SARS	SARS	NNP
cord-285806-363ivs67	127	25	-	-	HYPH
cord-285806-363ivs67	127	26	CoV-2	CoV-2	NNP
cord-285806-363ivs67	127	27	in	in	IN
cord-285806-363ivs67	127	28	severe	severe	JJ
cord-285806-363ivs67	127	29	cases	case	NNS
cord-285806-363ivs67	127	30	of	of	IN
cord-285806-363ivs67	127	31	COVID-19	covid-19	JJ
cord-285806-363ivs67	127	32	patients	patient	NNS
cord-285806-363ivs67	127	33	,	,	,
cord-285806-363ivs67	127	34	adopting	adopt	VBG
cord-285806-363ivs67	127	35	the	the	DT
cord-285806-363ivs67	127	36	same	same	JJ
cord-285806-363ivs67	127	37	criteria	criterion	NNS
cord-285806-363ivs67	127	38	of	of	IN
cord-285806-363ivs67	127	39	Tocilizumab	Tocilizumab	NNP
cord-285806-363ivs67	127	40	as	as	IN
cord-285806-363ivs67	127	41	to	to	IN
cord-285806-363ivs67	127	42	when	when	WRB
cord-285806-363ivs67	127	43	to	to	TO
cord-285806-363ivs67	127	44	start	start	VB
cord-285806-363ivs67	127	45	the	the	DT
cord-285806-363ivs67	127	46	treatment	treatment	NN
cord-285806-363ivs67	127	47	.	.	.
cord-285806-363ivs67	128	1	This	this	DT
cord-285806-363ivs67	128	2	option	option	NN
cord-285806-363ivs67	128	3	would	would	MD
cord-285806-363ivs67	128	4	provide	provide	VB
cord-285806-363ivs67	128	5	the	the	DT
cord-285806-363ivs67	128	6	benefit	benefit	NN
cord-285806-363ivs67	128	7	of	of	IN
cord-285806-363ivs67	128	8	targeting	target	VBG
cord-285806-363ivs67	128	9	only	only	RB
cord-285806-363ivs67	128	10	the	the	DT
cord-285806-363ivs67	128	11	pro	pro	JJ
cord-285806-363ivs67	128	12	-	-	JJ
cord-285806-363ivs67	128	13	inflammatory	inflammatory	JJ
cord-285806-363ivs67	128	14	trans	trans	NN
cord-285806-363ivs67	128	15	-	-	JJ
cord-285806-363ivs67	128	16	signaling	signal	VBG
cord-285806-363ivs67	128	17	pathway	pathway	NN
cord-285806-363ivs67	128	18	of	of	IN
cord-285806-363ivs67	128	19	IL-6	IL-6	NNP
cord-285806-363ivs67	128	20	,	,	,
cord-285806-363ivs67	128	21	instead	instead	RB
cord-285806-363ivs67	128	22	of	of	IN
cord-285806-363ivs67	128	23	targeting	target	VBG
cord-285806-363ivs67	128	24	them	-PRON-	PRP
cord-285806-363ivs67	128	25	both	both	DT
cord-285806-363ivs67	128	26	,	,	,
cord-285806-363ivs67	128	27	which	which	WDT
cord-285806-363ivs67	128	28	is	be	VBZ
cord-285806-363ivs67	128	29	something	something	NN
cord-285806-363ivs67	128	30	that	that	WDT
cord-285806-363ivs67	128	31	happens	happen	VBZ
cord-285806-363ivs67	128	32	with	with	IN
cord-285806-363ivs67	128	33	Tocilizumab	Tocilizumab	NNP
cord-285806-363ivs67	128	34	51	51	CD
cord-285806-363ivs67	128	35	.	.	.
cord-285806-363ivs67	129	1	Both	both	CC
cord-285806-363ivs67	129	2	the	the	DT
cord-285806-363ivs67	129	3	trans	trans	NN
cord-285806-363ivs67	129	4	-	-	NN
cord-285806-363ivs67	129	5	signaling	signaling	NN
cord-285806-363ivs67	129	6	and	and	CC
cord-285806-363ivs67	129	7	the	the	DT
cord-285806-363ivs67	129	8	classic	classic	RB
cord-285806-363ivs67	129	9	-	-	HYPH
cord-285806-363ivs67	129	10	signaling	signal	VBG
cord-285806-363ivs67	129	11	pathways	pathway	NNS
cord-285806-363ivs67	129	12	of	of	IN
cord-285806-363ivs67	129	13	IL-6	IL-6	NNP
cord-285806-363ivs67	129	14	converge	converge	VBP
cord-285806-363ivs67	129	15	in	in	IN
cord-285806-363ivs67	129	16	the	the	DT
cord-285806-363ivs67	129	17	activation	activation	NN
cord-285806-363ivs67	129	18	of	of	IN
cord-285806-363ivs67	129	19	the	the	DT
cord-285806-363ivs67	129	20	JAK	JAK	NNP
cord-285806-363ivs67	129	21	/	/	SYM
cord-285806-363ivs67	129	22	STAT	STAT	NNP
cord-285806-363ivs67	129	23	pathway	pathway	NN
cord-285806-363ivs67	129	24	and	and	CC
cord-285806-363ivs67	129	25	the	the	DT
cord-285806-363ivs67	129	26	MAPK	MAPK	NNP
cord-285806-363ivs67	129	27	cascade	cascade	NN
cord-285806-363ivs67	129	28	77	77	CD
cord-285806-363ivs67	129	29	.	.	.
cord-285806-363ivs67	130	1	The	the	DT
cord-285806-363ivs67	130	2	next	next	JJ
cord-285806-363ivs67	130	3	step	step	NN
cord-285806-363ivs67	130	4	after	after	IN
cord-285806-363ivs67	130	5	binding	bind	VBG
cord-285806-363ivs67	130	6	of	of	IN
cord-285806-363ivs67	130	7	IL-6	IL-6	NNP
cord-285806-363ivs67	130	8	to	to	IN
cord-285806-363ivs67	130	9	IL-6R	IL-6R	NNP
cord-285806-363ivs67	131	1	and	and	CC
cord-285806-363ivs67	131	2	sgp130	sgp130	NNPS
cord-285806-363ivs67	131	3	is	be	VBZ
cord-285806-363ivs67	131	4	then	then	RB
cord-285806-363ivs67	131	5	to	to	TO
cord-285806-363ivs67	131	6	initiate	initiate	VB
cord-285806-363ivs67	131	7	intracellular	intracellular	JJ
cord-285806-363ivs67	131	8	signal	signal	NN
cord-285806-363ivs67	131	9	transduction	transduction	NN
cord-285806-363ivs67	131	10	.	.	.
cord-285806-363ivs67	132	1	The	the	DT
cord-285806-363ivs67	132	2	signal	signal	NN
cord-285806-363ivs67	132	3	transfer	transfer	NN
cord-285806-363ivs67	132	4	is	be	VBZ
cord-285806-363ivs67	132	5	performed	perform	VBN
cord-285806-363ivs67	132	6	by	by	IN
cord-285806-363ivs67	132	7	the	the	DT
cord-285806-363ivs67	132	8	Janus	Janus	NNP
cord-285806-363ivs67	132	9	-	-	HYPH
cord-285806-363ivs67	132	10	kinase	kinase	NNP
cord-285806-363ivs67	132	11	/	/	SYM
cord-285806-363ivs67	132	12	Signal	signal	NN
cord-285806-363ivs67	132	13	transducer	transducer	NN
cord-285806-363ivs67	132	14	and	and	CC
cord-285806-363ivs67	132	15	activator	activator	NN
cord-285806-363ivs67	132	16	of	of	IN
cord-285806-363ivs67	132	17	transcription	transcription	NN
cord-285806-363ivs67	133	1	(	(	-LRB-
cord-285806-363ivs67	133	2	Jak	Jak	NNP
cord-285806-363ivs67	133	3	/	/	SYM
cord-285806-363ivs67	133	4	STAT)-,mainly	stat)-,mainly	RB
cord-285806-363ivs67	133	5	STAT1	stat1	XX
cord-285806-363ivs67	134	1	,	,	,
cord-285806-363ivs67	134	2	STAT3	STAT3	NNP
cord-285806-363ivs67	134	3	isoforms	isoform	NNS
cord-285806-363ivs67	134	4	[	[	-LRB-
cord-285806-363ivs67	134	5	78	78	CD
cord-285806-363ivs67	134	6	]	]	-RRB-
cord-285806-363ivs67	134	7	[	[	-LRB-
cord-285806-363ivs67	134	8	79	79	CD
cord-285806-363ivs67	134	9	]	]	-RRB-
cord-285806-363ivs67	135	1	[	[	-LRB-
cord-285806-363ivs67	135	2	80	80	CD
cord-285806-363ivs67	135	3	]	]	-RRB-
cord-285806-363ivs67	135	4	,	,	.
cord-285806-363ivs67	136	1	mitogen	mitogen	NNP
cord-285806-363ivs67	136	2	-	-	HYPH
cord-285806-363ivs67	136	3	activated	activate	VBN
cord-285806-363ivs67	136	4	protein	protein	NN
cord-285806-363ivs67	136	5	kinase	kinase	NN
cord-285806-363ivs67	136	6	(	(	-LRB-
cord-285806-363ivs67	136	7	MAPK)-and	MAPK)-and	NNP
cord-285806-363ivs67	136	8	phosphatidyl	phosphatidyl	NN
cord-285806-363ivs67	136	9	-	-	HYPH
cord-285806-363ivs67	136	10	inositol-3-kinase	inositol-3-kinase	NNP
cord-285806-363ivs67	136	11	(	(	-LRB-
cord-285806-363ivs67	136	12	PI3K)-pathway	pi3k)-pathway	RB
cord-285806-363ivs67	136	13	44	44	CD
cord-285806-363ivs67	136	14	,	,	,
cord-285806-363ivs67	136	15	77	77	CD
cord-285806-363ivs67	136	16	.	.	.
cord-285806-363ivs67	137	1	Another	another	DT
cord-285806-363ivs67	137	2	possible	possible	JJ
cord-285806-363ivs67	137	3	way	way	NN
cord-285806-363ivs67	137	4	of	of	IN
cord-285806-363ivs67	137	5	counteracting	counteract	VBG
cord-285806-363ivs67	137	6	IL-6	IL-6	NNP
cord-285806-363ivs67	137	7	action	action	NN
cord-285806-363ivs67	137	8	is	be	VBZ
cord-285806-363ivs67	137	9	then	then	RB
cord-285806-363ivs67	137	10	to	to	TO
cord-285806-363ivs67	137	11	inhibit	inhibit	VB
cord-285806-363ivs67	137	12	its	-PRON-	PRP$
cord-285806-363ivs67	137	13	intracellular	intracellular	JJ
cord-285806-363ivs67	137	14	transduction	transduction	NN
cord-285806-363ivs67	137	15	pathway	pathway	NN
cord-285806-363ivs67	137	16	,	,	,
cord-285806-363ivs67	137	17	though	though	IN
cord-285806-363ivs67	137	18	in	in	IN
cord-285806-363ivs67	137	19	doing	do	VBG
cord-285806-363ivs67	137	20	so	so	RB
cord-285806-363ivs67	137	21	the	the	DT
cord-285806-363ivs67	137	22	benefit	benefit	NN
cord-285806-363ivs67	137	23	of	of	IN
cord-285806-363ivs67	137	24	specifically	specifically	RB
cord-285806-363ivs67	137	25	targeting	target	VBG
cord-285806-363ivs67	137	26	the	the	DT
cord-285806-363ivs67	137	27	pro	pro	JJ
cord-285806-363ivs67	137	28	-	-	JJ
cord-285806-363ivs67	137	29	inflammatory	inflammatory	JJ
cord-285806-363ivs67	137	30	trans	trans	NN
cord-285806-363ivs67	137	31	-	-	JJ
cord-285806-363ivs67	137	32	signaling	signal	VBG
cord-285806-363ivs67	137	33	pathway	pathway	NN
cord-285806-363ivs67	137	34	is	be	VBZ
cord-285806-363ivs67	137	35	lost	lose	VBN
cord-285806-363ivs67	137	36	.	.	.
cord-285806-363ivs67	138	1	This	this	DT
cord-285806-363ivs67	138	2	can	can	MD
cord-285806-363ivs67	138	3	be	be	VB
cord-285806-363ivs67	138	4	done	do	VBN
cord-285806-363ivs67	138	5	by	by	IN
cord-285806-363ivs67	138	6	inhibiting	inhibit	VBG
cord-285806-363ivs67	138	7	the	the	DT
cord-285806-363ivs67	138	8	JAK	JAK	NNP
cord-285806-363ivs67	138	9	1/2	1/2	CD
cord-285806-363ivs67	138	10	pathway	pathway	NN
cord-285806-363ivs67	138	11	with	with	IN
cord-285806-363ivs67	138	12	drugs	drug	NNS
cord-285806-363ivs67	138	13	like	like	IN
cord-285806-363ivs67	138	14	Ruxolitinib	Ruxolitinib	NNP
cord-285806-363ivs67	138	15	.	.	.
cord-285806-363ivs67	139	1	Ruxolitinib	Ruxolitinib	NNP
cord-285806-363ivs67	139	2	is	be	VBZ
cord-285806-363ivs67	139	3	a	a	DT
cord-285806-363ivs67	139	4	small	small	JJ
cord-285806-363ivs67	139	5	drug	drug	NN
cord-285806-363ivs67	139	6	belonging	belong	VBG
cord-285806-363ivs67	139	7	to	to	IN
cord-285806-363ivs67	139	8	the	the	DT
cord-285806-363ivs67	139	9	class	class	NN
cord-285806-363ivs67	139	10	of	of	IN
cord-285806-363ivs67	139	11	Janus	Janus	NNP
cord-285806-363ivs67	139	12	kinase	kinase	NN
cord-285806-363ivs67	139	13	(	(	-LRB-
cord-285806-363ivs67	139	14	JAK	JAK	NNP
cord-285806-363ivs67	139	15	)	)	-RRB-
cord-285806-363ivs67	139	16	inhibitors	inhibitor	NNS
cord-285806-363ivs67	139	17	and	and	CC
cord-285806-363ivs67	139	18	currently	currently	RB
cord-285806-363ivs67	139	19	clinically	clinically	RB
cord-285806-363ivs67	139	20	used	use	VBN
cord-285806-363ivs67	139	21	in	in	IN
cord-285806-363ivs67	139	22	the	the	DT
cord-285806-363ivs67	139	23	treatment	treatment	NN
cord-285806-363ivs67	139	24	of	of	IN
cord-285806-363ivs67	139	25	JAK2	JAK2	NNP
cord-285806-363ivs67	139	26	mutated	mutate	VBD
cord-285806-363ivs67	139	27	myeloproliferative	myeloproliferative	JJ
cord-285806-363ivs67	139	28	neoplasms	neoplasm	NNS
cord-285806-363ivs67	139	29	,	,	,
cord-285806-363ivs67	139	30	including	include	VBG
cord-285806-363ivs67	139	31	myelofibrosis	myelofibrosis	NNP
cord-285806-363ivs67	139	32	and	and	CC
cord-285806-363ivs67	139	33	polycythemia	polycythemia	NN
cord-285806-363ivs67	139	34	vera	vera	NNP
cord-285806-363ivs67	139	35	81	81	CD
cord-285806-363ivs67	139	36	,	,	,
cord-285806-363ivs67	139	37	82	82	CD
cord-285806-363ivs67	139	38	.	.	.
cord-285806-363ivs67	140	1	It	-PRON-	PRP
cord-285806-363ivs67	140	2	shows	show	VBZ
cord-285806-363ivs67	140	3	activity	activity	NN
cord-285806-363ivs67	140	4	against	against	IN
cord-285806-363ivs67	140	5	the	the	DT
cord-285806-363ivs67	140	6	JAK2	JAK2	NNP
cord-285806-363ivs67	140	7	isoform	isoform	NN
cord-285806-363ivs67	140	8	and	and	CC
cord-285806-363ivs67	140	9	also	also	RB
cord-285806-363ivs67	140	10	the	the	DT
cord-285806-363ivs67	140	11	JAK1	JAK1	NNP
cord-285806-363ivs67	140	12	isoform	isoform	NN
cord-285806-363ivs67	140	13	,	,	,
cord-285806-363ivs67	140	14	which	which	WDT
cord-285806-363ivs67	140	15	plays	play	VBZ
cord-285806-363ivs67	140	16	a	a	DT
cord-285806-363ivs67	140	17	major	major	JJ
cord-285806-363ivs67	140	18	role	role	NN
cord-285806-363ivs67	140	19	in	in	IN
cord-285806-363ivs67	140	20	the	the	DT
cord-285806-363ivs67	140	21	signaling	signal	VBG
cord-285806-363ivs67	140	22	pathway	pathway	NN
cord-285806-363ivs67	140	23	of	of	IN
cord-285806-363ivs67	140	24	inflammatory	inflammatory	JJ
cord-285806-363ivs67	140	25	cytokines	cytokine	NNS
cord-285806-363ivs67	140	26	83	83	CD
cord-285806-363ivs67	140	27	.	.	.
cord-285806-363ivs67	141	1	JAK3	JAK3	NNP
cord-285806-363ivs67	141	2	seems	seem	VBZ
cord-285806-363ivs67	141	3	to	to	TO
cord-285806-363ivs67	141	4	be	be	VB
cord-285806-363ivs67	141	5	less	less	RBR
cord-285806-363ivs67	141	6	sensitive	sensitive	JJ
cord-285806-363ivs67	141	7	to	to	IN
cord-285806-363ivs67	141	8	ruxolitinib	ruxolitinib	NNP
cord-285806-363ivs67	141	9	84	84	CD
cord-285806-363ivs67	141	10	,	,	,
cord-285806-363ivs67	141	11	it	-PRON-	PRP
cord-285806-363ivs67	141	12	also	also	RB
cord-285806-363ivs67	141	13	shows	show	VBZ
cord-285806-363ivs67	141	14	anti	anti	JJ
cord-285806-363ivs67	141	15	-	-	JJ
cord-285806-363ivs67	141	16	inflammatory	inflammatory	JJ
cord-285806-363ivs67	141	17	activity	activity	NN
cord-285806-363ivs67	141	18	which	which	WDT
cord-285806-363ivs67	141	19	may	may	MD
cord-285806-363ivs67	141	20	be	be	VB
cord-285806-363ivs67	141	21	beneficial	beneficial	JJ
cord-285806-363ivs67	141	22	in	in	IN
cord-285806-363ivs67	141	23	its	-PRON-	PRP$
cord-285806-363ivs67	141	24	clinical	clinical	JJ
cord-285806-363ivs67	141	25	use	use	NN
cord-285806-363ivs67	141	26	85	85	CD
cord-285806-363ivs67	141	27	;	;	:
cord-285806-363ivs67	141	28	it	-PRON-	PRP
cord-285806-363ivs67	141	29	is	be	VBZ
cord-285806-363ivs67	141	30	also	also	RB
cord-285806-363ivs67	141	31	implicated	implicate	VBN
cord-285806-363ivs67	141	32	in	in	IN
cord-285806-363ivs67	141	33	the	the	DT
cord-285806-363ivs67	141	34	suppression	suppression	NN
cord-285806-363ivs67	141	35	of	of	IN
cord-285806-363ivs67	141	36	the	the	DT
cord-285806-363ivs67	141	37	harmful	harmful	JJ
cord-285806-363ivs67	141	38	consequences	consequence	NNS
cord-285806-363ivs67	141	39	of	of	IN
cord-285806-363ivs67	141	40	macrophage	macrophage	NN
cord-285806-363ivs67	141	41	activation	activation	NN
cord-285806-363ivs67	141	42	hemophagocytic	hemophagocytic	NNP
cord-285806-363ivs67	141	43	lymphohistiocytosis	lymphohistiocytosis	NNP
cord-285806-363ivs67	141	44	86	86	CD
cord-285806-363ivs67	141	45	,	,	,
cord-285806-363ivs67	141	46	which	which	WDT
cord-285806-363ivs67	141	47	is	be	VBZ
cord-285806-363ivs67	141	48	an	an	DT
cord-285806-363ivs67	141	49	underrecognized	underrecognized	JJ
cord-285806-363ivs67	141	50	hyperinflammatory	hyperinflammatory	NNP
cord-285806-363ivs67	141	51	syndrome	syndrome	NN
cord-285806-363ivs67	141	52	characterized	characterize	VBN
cord-285806-363ivs67	141	53	by	by	IN
cord-285806-363ivs67	141	54	fulminant	fulminant	JJ
cord-285806-363ivs67	141	55	and	and	CC
cord-285806-363ivs67	141	56	fatal	fatal	JJ
cord-285806-363ivs67	141	57	hypercytokinemia	hypercytokinemia	NN
cord-285806-363ivs67	141	58	with	with	IN
cord-285806-363ivs67	141	59	multi	multi	JJ
cord-285806-363ivs67	141	60	organ	organ	NN
cord-285806-363ivs67	141	61	failure	failure	NN
cord-285806-363ivs67	141	62	87	87	CD
cord-285806-363ivs67	141	63	.	.	.
cord-285806-363ivs67	142	1	It	-PRON-	PRP
cord-285806-363ivs67	142	2	has	have	VBZ
cord-285806-363ivs67	142	3	been	be	VBN
cord-285806-363ivs67	142	4	proven	prove	VBN
cord-285806-363ivs67	142	5	that	that	IN
cord-285806-363ivs67	142	6	the	the	DT
cord-285806-363ivs67	142	7	expression	expression	NN
cord-285806-363ivs67	142	8	of	of	IN
cord-285806-363ivs67	142	9	major	major	JJ
cord-285806-363ivs67	142	10	inflammatory	inflammatory	JJ
cord-285806-363ivs67	142	11	cytokines	cytokine	NNS
cord-285806-363ivs67	142	12	such	such	JJ
cord-285806-363ivs67	142	13	as	as	IN
cord-285806-363ivs67	142	14	TNF	TNF	NNP
cord-285806-363ivs67	142	15	alfa	alfa	NNP
cord-285806-363ivs67	142	16	and	and	CC
cord-285806-363ivs67	142	17	IL6	IL6	NNP
cord-285806-363ivs67	142	18	was	be	VBD
cord-285806-363ivs67	142	19	highly	highly	RB
cord-285806-363ivs67	142	20	reduced	reduce	VBN
cord-285806-363ivs67	142	21	in	in	IN
cord-285806-363ivs67	142	22	inflammatory	inflammatory	JJ
cord-285806-363ivs67	142	23	human	human	JJ
cord-285806-363ivs67	142	24	macrophages	macrophage	NNS
cord-285806-363ivs67	142	25	exposed	expose	VBN
cord-285806-363ivs67	142	26	to	to	IN
cord-285806-363ivs67	142	27	ruxolitinib	ruxolitinib	NNP
cord-285806-363ivs67	142	28	85	85	CD
cord-285806-363ivs67	142	29	.	.	.
cord-285806-363ivs67	143	1	It	-PRON-	PRP
cord-285806-363ivs67	143	2	has	have	VBZ
cord-285806-363ivs67	143	3	also	also	RB
cord-285806-363ivs67	143	4	been	be	VBN
cord-285806-363ivs67	143	5	shown	show	VBN
cord-285806-363ivs67	143	6	through	through	IN
cord-285806-363ivs67	143	7	an	an	DT
cord-285806-363ivs67	143	8	analysis	analysis	NN
cord-285806-363ivs67	143	9	of	of	IN
cord-285806-363ivs67	143	10	mRNA	mRNA	NNP
cord-285806-363ivs67	143	11	expression	expression	NN
cord-285806-363ivs67	143	12	of	of	IN
cord-285806-363ivs67	143	13	cytokines	cytokine	NNS
cord-285806-363ivs67	143	14	by	by	IN
cord-285806-363ivs67	143	15	PCR	PCR	NNP
cord-285806-363ivs67	143	16	array	array	NN
cord-285806-363ivs67	143	17	that	that	IN
cord-285806-363ivs67	143	18	the	the	DT
cord-285806-363ivs67	143	19	major	major	JJ
cord-285806-363ivs67	143	20	inflammatory	inflammatory	JJ
cord-285806-363ivs67	143	21	cytokines	cytokine	NNS
cord-285806-363ivs67	143	22	,	,	,
cord-285806-363ivs67	143	23	IL-6	IL-6	NNP
cord-285806-363ivs67	143	24	and	and	CC
cord-285806-363ivs67	143	25	TNF	TNF	NNP
cord-285806-363ivs67	143	26	alfa	alfa	NNP
cord-285806-363ivs67	143	27	,	,	,
cord-285806-363ivs67	143	28	were	be	VBD
cord-285806-363ivs67	143	29	highly	highly	RB
cord-285806-363ivs67	143	30	reduced	reduce	VBN
cord-285806-363ivs67	143	31	and	and	CC
cord-285806-363ivs67	143	32	down	down	RB
cord-285806-363ivs67	143	33	-	-	HYPH
cord-285806-363ivs67	143	34	regulated	regulate	VBN
cord-285806-363ivs67	143	35	by	by	IN
cord-285806-363ivs67	143	36	ruxolitinib	ruxolitinib	NNP
cord-285806-363ivs67	143	37	at	at	IN
cord-285806-363ivs67	143	38	both	both	CC
cord-285806-363ivs67	143	39	protein	protein	NN
cord-285806-363ivs67	143	40	and	and	CC
cord-285806-363ivs67	143	41	mRNA	mrna	NN
cord-285806-363ivs67	144	1	level	level	NN
cord-285806-363ivs67	144	2	88	88	CD
cord-285806-363ivs67	144	3	.	.	.
cord-285806-363ivs67	145	1	All	all	PDT
cord-285806-363ivs67	145	2	these	these	DT
cord-285806-363ivs67	145	3	results	result	NNS
cord-285806-363ivs67	145	4	point	point	VBP
cord-285806-363ivs67	145	5	towards	towards	IN
cord-285806-363ivs67	145	6	a	a	DT
cord-285806-363ivs67	145	7	possible	possible	JJ
cord-285806-363ivs67	145	8	use	use	NN
cord-285806-363ivs67	145	9	of	of	IN
cord-285806-363ivs67	145	10	Ruxolitinib	Ruxolitinib	NNP
cord-285806-363ivs67	145	11	as	as	IN
cord-285806-363ivs67	145	12	an	an	DT
cord-285806-363ivs67	145	13	IL-6	IL-6	NNP
cord-285806-363ivs67	145	14	inhibitor	inhibitor	NN
cord-285806-363ivs67	145	15	like	like	IN
cord-285806-363ivs67	145	16	Tocilizumab	Tocilizumab	NNP
cord-285806-363ivs67	145	17	in	in	IN
cord-285806-363ivs67	145	18	the	the	DT
cord-285806-363ivs67	145	19	advanced	advanced	JJ
cord-285806-363ivs67	145	20	stages	stage	NNS
cord-285806-363ivs67	145	21	of	of	IN
cord-285806-363ivs67	145	22	COVID-19	COVID-19	NNP
cord-285806-363ivs67	145	23	.	.	.
cord-285806-363ivs67	146	1	This	this	DT
cord-285806-363ivs67	146	2	drug	drug	NN
cord-285806-363ivs67	146	3	is	be	VBZ
cord-285806-363ivs67	146	4	currently	currently	RB
cord-285806-363ivs67	146	5	being	be	VBG
cord-285806-363ivs67	146	6	tested	test	VBN
cord-285806-363ivs67	146	7	in	in	IN
cord-285806-363ivs67	146	8	some	some	DT
cord-285806-363ivs67	146	9	patients	patient	NNS
cord-285806-363ivs67	146	10	in	in	IN
cord-285806-363ivs67	146	11	Italy	Italy	NNP
cord-285806-363ivs67	147	1	(	(	-LRB-
cord-285806-363ivs67	147	2	CINC424	CINC424	NNP
cord-285806-363ivs67	147	3	,	,	,
cord-285806-363ivs67	147	4	RUXOLITINIB	RUXOLITINIB	NNP
cord-285806-363ivs67	147	5	)	)	-RRB-
cord-285806-363ivs67	147	6	.	.	.
cord-285806-363ivs67	148	1	Baricitinib	Baricitinib	NNP
cord-285806-363ivs67	148	2	has	have	VBZ
cord-285806-363ivs67	148	3	been	be	VBN
cord-285806-363ivs67	148	4	suggested	suggest	VBN
cord-285806-363ivs67	148	5	to	to	TO
cord-285806-363ivs67	148	6	be	be	VB
cord-285806-363ivs67	148	7	of	of	IN
cord-285806-363ivs67	148	8	therapeutic	therapeutic	JJ
cord-285806-363ivs67	148	9	use	use	NN
cord-285806-363ivs67	148	10	against	against	IN
cord-285806-363ivs67	148	11	SARS	SARS	NNP
cord-285806-363ivs67	148	12	-	-	HYPH
cord-285806-363ivs67	148	13	CoV-2	CoV-2	NNP
cord-285806-363ivs67	148	14	by	by	IN
cord-285806-363ivs67	148	15	Artificial	Artificial	NNP
cord-285806-363ivs67	148	16	Intelligence	Intelligence	NNP
cord-285806-363ivs67	148	17	algorithms	algorithm	NNS
cord-285806-363ivs67	148	18	89	89	CD
cord-285806-363ivs67	148	19	.	.	.
cord-285806-363ivs67	149	1	It	-PRON-	PRP
cord-285806-363ivs67	149	2	is	be	VBZ
cord-285806-363ivs67	149	3	a	a	DT
cord-285806-363ivs67	149	4	selective	selective	JJ
cord-285806-363ivs67	149	5	and	and	CC
cord-285806-363ivs67	149	6	powerful	powerful	JJ
cord-285806-363ivs67	149	7	JAK	JAK	NNP
cord-285806-363ivs67	149	8	-	-	HYPH
cord-285806-363ivs67	149	9	STAT	STAT	NNP
cord-285806-363ivs67	149	10	signaling	signal	VBG
cord-285806-363ivs67	149	11	inhibitor	inhibitor	NN
cord-285806-363ivs67	149	12	thus	thus	RB
cord-285806-363ivs67	149	13	being	be	VBG
cord-285806-363ivs67	149	14	effective	effective	JJ
cord-285806-363ivs67	149	15	against	against	IN
cord-285806-363ivs67	149	16	the	the	DT
cord-285806-363ivs67	149	17	consequences	consequence	NNS
cord-285806-363ivs67	149	18	of	of	IN
cord-285806-363ivs67	149	19	the	the	DT
cord-285806-363ivs67	149	20	elevated	elevated	JJ
cord-285806-363ivs67	149	21	levels	level	NNS
cord-285806-363ivs67	149	22	of	of	IN
cord-285806-363ivs67	149	23	cytokines	cytokine	NNS
cord-285806-363ivs67	149	24	,	,	,
cord-285806-363ivs67	149	25	not	not	RB
cord-285806-363ivs67	149	26	only	only	RB
cord-285806-363ivs67	149	27	being	be	VBG
cord-285806-363ivs67	149	28	able	able	JJ
cord-285806-363ivs67	149	29	of	of	IN
cord-285806-363ivs67	149	30	lowering	lower	VBG
cord-285806-363ivs67	149	31	IL-6	IL-6	NNP
cord-285806-363ivs67	149	32	levels	level	NNS
cord-285806-363ivs67	149	33	90	90	CD
cord-285806-363ivs67	149	34	,	,	,
cord-285806-363ivs67	149	35	but	but	CC
cord-285806-363ivs67	149	36	it	-PRON-	PRP
cord-285806-363ivs67	149	37	also	also	RB
cord-285806-363ivs67	149	38	has	have	VBZ
cord-285806-363ivs67	149	39	the	the	DT
cord-285806-363ivs67	149	40	potential	potential	NN
cord-285806-363ivs67	149	41	to	to	TO
cord-285806-363ivs67	149	42	inhibit	inhibit	VB
cord-285806-363ivs67	149	43	clathrin	clathrin	NN
cord-285806-363ivs67	149	44	-	-	HYPH
cord-285806-363ivs67	149	45	mediated	mediate	VBN
cord-285806-363ivs67	149	46	endocytosis	endocytosis	NN
cord-285806-363ivs67	149	47	and	and	CC
cord-285806-363ivs67	149	48	thereby	thereby	RB
cord-285806-363ivs67	149	49	inhibit	inhibit	VB
cord-285806-363ivs67	149	50	viral	viral	JJ
cord-285806-363ivs67	149	51	infection	infection	NN
cord-285806-363ivs67	149	52	of	of	IN
cord-285806-363ivs67	149	53	cells	cell	NNS
cord-285806-363ivs67	149	54	.	.	.
cord-285806-363ivs67	150	1	It	-PRON-	PRP
cord-285806-363ivs67	150	2	targets	target	VBZ
cord-285806-363ivs67	150	3	members	member	NNS
cord-285806-363ivs67	150	4	of	of	IN
cord-285806-363ivs67	150	5	the	the	DT
cord-285806-363ivs67	150	6	numb	numb	NN
cord-285806-363ivs67	150	7	-	-	HYPH
cord-285806-363ivs67	150	8	associated	associate	VBN
cord-285806-363ivs67	150	9	kinase	kinase	NN
cord-285806-363ivs67	150	10	(	(	-LRB-
cord-285806-363ivs67	150	11	NAK	NAK	NNP
cord-285806-363ivs67	150	12	)	)	-RRB-
cord-285806-363ivs67	150	13	family	family	NN
cord-285806-363ivs67	150	14	(	(	-LRB-
cord-285806-363ivs67	150	15	AAK1	AAK1	NNP
cord-285806-363ivs67	150	16	and	and	CC
cord-285806-363ivs67	150	17	GAK	GAK	NNP
cord-285806-363ivs67	150	18	)	)	-RRB-
cord-285806-363ivs67	150	19	,	,	,
cord-285806-363ivs67	150	20	the	the	DT
cord-285806-363ivs67	150	21	inhibition	inhibition	NN
cord-285806-363ivs67	150	22	of	of	IN
cord-285806-363ivs67	150	23	which	which	WDT
cord-285806-363ivs67	150	24	has	have	VBZ
cord-285806-363ivs67	150	25	been	be	VBN
cord-285806-363ivs67	150	26	shown	show	VBN
cord-285806-363ivs67	150	27	to	to	TO
cord-285806-363ivs67	150	28	reduce	reduce	VB
cord-285806-363ivs67	150	29	viral	viral	JJ
cord-285806-363ivs67	150	30	infection	infection	NN
cord-285806-363ivs67	150	31	in	in	IN
cord-285806-363ivs67	150	32	vitro	vitro	FW
cord-285806-363ivs67	150	33	91	91	CD
cord-285806-363ivs67	150	34	.	.	.
cord-285806-363ivs67	151	1	It	-PRON-	PRP
cord-285806-363ivs67	151	2	can	can	MD
cord-285806-363ivs67	151	3	be	be	VB
cord-285806-363ivs67	151	4	administered	administer	VBN
cord-285806-363ivs67	151	5	orally	orally	RB
cord-285806-363ivs67	151	6	and	and	CC
cord-285806-363ivs67	151	7	has	have	VBZ
cord-285806-363ivs67	151	8	acceptable	acceptable	JJ
cord-285806-363ivs67	151	9	side	side	NN
cord-285806-363ivs67	151	10	effect	effect	NN
cord-285806-363ivs67	151	11	profile	profile	NN
cord-285806-363ivs67	151	12	,	,	,
cord-285806-363ivs67	151	13	besides	besides	IN
cord-285806-363ivs67	151	14	having	have	VBG
cord-285806-363ivs67	151	15	little	little	JJ
cord-285806-363ivs67	151	16	interaction	interaction	NN
cord-285806-363ivs67	151	17	with	with	IN
cord-285806-363ivs67	151	18	CYP	CYP	NNP
cord-285806-363ivs67	151	19	enzymes	enzyme	NNS
cord-285806-363ivs67	151	20	and	and	CC
cord-285806-363ivs67	151	21	drug	drug	NN
cord-285806-363ivs67	151	22	transporters	transporter	NNS
cord-285806-363ivs67	151	23	89	89	CD
cord-285806-363ivs67	151	24	.	.	.
cord-285806-363ivs67	152	1	This	this	DT
cord-285806-363ivs67	152	2	makes	make	VBZ
cord-285806-363ivs67	152	3	Baricinitib	Baricinitib	NNP
cord-285806-363ivs67	152	4	a	a	DT
cord-285806-363ivs67	152	5	valid	valid	JJ
cord-285806-363ivs67	152	6	option	option	NN
cord-285806-363ivs67	152	7	in	in	IN
cord-285806-363ivs67	152	8	every	every	DT
cord-285806-363ivs67	152	9	phase	phase	NN
cord-285806-363ivs67	152	10	of	of	IN
cord-285806-363ivs67	152	11	the	the	DT
cord-285806-363ivs67	152	12	viral	viral	JJ
cord-285806-363ivs67	152	13	infection	infection	NN
cord-285806-363ivs67	152	14	,	,	,
cord-285806-363ivs67	152	15	the	the	DT
cord-285806-363ivs67	152	16	early	early	JJ
cord-285806-363ivs67	152	17	stages	stage	NNS
cord-285806-363ivs67	152	18	to	to	TO
cord-285806-363ivs67	152	19	reduce	reduce	VB
cord-285806-363ivs67	152	20	viral	viral	JJ
cord-285806-363ivs67	152	21	entry	entry	NN
cord-285806-363ivs67	152	22	in	in	IN
cord-285806-363ivs67	152	23	the	the	DT
cord-285806-363ivs67	152	24	cells	cell	NNS
cord-285806-363ivs67	152	25	,	,	,
cord-285806-363ivs67	152	26	and	and	CC
cord-285806-363ivs67	152	27	later	later	RB
cord-285806-363ivs67	152	28	stages	stage	NNS
cord-285806-363ivs67	152	29	for	for	IN
cord-285806-363ivs67	152	30	its	-PRON-	PRP$
cord-285806-363ivs67	152	31	anti	anti	JJ
cord-285806-363ivs67	152	32	-	-	JJ
cord-285806-363ivs67	152	33	inflammatory	inflammatory	JJ
cord-285806-363ivs67	152	34	properties	property	NNS
cord-285806-363ivs67	152	35	.	.	.
cord-285806-363ivs67	153	1	Other	other	JJ
cord-285806-363ivs67	153	2	monoclonal	monoclonal	JJ
cord-285806-363ivs67	153	3	antibodies	antibody	NNS
cord-285806-363ivs67	153	4	against	against	IN
cord-285806-363ivs67	153	5	IL-6	IL-6	NNP
cord-285806-363ivs67	153	6	are	be	VBP
cord-285806-363ivs67	153	7	sirukumab	sirukumab	VBN
cord-285806-363ivs67	153	8	(	(	-LRB-
cord-285806-363ivs67	153	9	CNTO136	CNTO136	NNP
cord-285806-363ivs67	153	10	)	)	-RRB-
cord-285806-363ivs67	153	11	,	,	,
cord-285806-363ivs67	153	12	olokizumab	olokizumab	VBN
cord-285806-363ivs67	153	13	(	(	-LRB-
cord-285806-363ivs67	153	14	CP6038	cp6038	NN
cord-285806-363ivs67	153	15	)	)	-RRB-
cord-285806-363ivs67	153	16	,	,	,
cord-285806-363ivs67	153	17	PF-423691	PF-423691	NNS
cord-285806-363ivs67	153	18	,	,	,
cord-285806-363ivs67	153	19	elsilimomab	elsilimomab	NNP
cord-285806-363ivs67	153	20	(	(	-LRB-
cord-285806-363ivs67	153	21	BE-8	BE-8	NNP
cord-285806-363ivs67	153	22	)	)	-RRB-
cord-285806-363ivs67	154	1	,	,	,
cord-285806-363ivs67	154	2	clazakizumab	clazakizumab	NNP
cord-285806-363ivs67	154	3	(	(	-LRB-
cord-285806-363ivs67	154	4	BMS945429	BMS945429	NNP
cord-285806-363ivs67	154	5	)	)	-RRB-
cord-285806-363ivs67	154	6	,	,	,
cord-285806-363ivs67	154	7	which	which	WDT
cord-285806-363ivs67	154	8	are	be	VBP
cord-285806-363ivs67	154	9	in	in	IN
cord-285806-363ivs67	154	10	different	different	JJ
cord-285806-363ivs67	154	11	phases	phase	NNS
cord-285806-363ivs67	154	12	of	of	IN
cord-285806-363ivs67	154	13	clinical	clinical	JJ
cord-285806-363ivs67	154	14	trials	trial	NNS
cord-285806-363ivs67	154	15	to	to	TO
cord-285806-363ivs67	154	16	establish	establish	VB
cord-285806-363ivs67	154	17	their	-PRON-	PRP$
cord-285806-363ivs67	154	18	efficacy	efficacy	NN
cord-285806-363ivs67	154	19	and	and	CC
cord-285806-363ivs67	154	20	safety	safety	NN
cord-285806-363ivs67	154	21	in	in	IN
cord-285806-363ivs67	154	22	varied	varied	JJ
cord-285806-363ivs67	154	23	disease	disease	NN
cord-285806-363ivs67	154	24	states	state	NNS
cord-285806-363ivs67	154	25	[	[	-LRB-
cord-285806-363ivs67	154	26	92	92	CD
cord-285806-363ivs67	154	27	]	]	-RRB-
cord-285806-363ivs67	155	1	[	[	-LRB-
cord-285806-363ivs67	155	2	93	93	CD
cord-285806-363ivs67	155	3	]	]	-RRB-
cord-285806-363ivs67	156	1	[	[	-LRB-
cord-285806-363ivs67	156	2	94	94	CD
cord-285806-363ivs67	156	3	]	]	-RRB-
cord-285806-363ivs67	156	4	[	[	-LRB-
cord-285806-363ivs67	156	5	95	95	CD
cord-285806-363ivs67	156	6	]	]	-RRB-
cord-285806-363ivs67	157	1	[	[	-LRB-
cord-285806-363ivs67	157	2	96	96	CD
cord-285806-363ivs67	157	3	]	]	-RRB-
cord-285806-363ivs67	157	4	[	[	-LRB-
cord-285806-363ivs67	157	5	97	97	CD
cord-285806-363ivs67	157	6	]	]	-RRB-
cord-285806-363ivs67	157	7	.	.	.
cord-285806-363ivs67	158	1	Sarilumab	Sarilumab	NNP
cord-285806-363ivs67	158	2	,	,	,
cord-285806-363ivs67	158	3	another	another	DT
cord-285806-363ivs67	158	4	monoclonal	monoclonal	JJ
cord-285806-363ivs67	158	5	antibody	antibody	NN
cord-285806-363ivs67	158	6	against	against	IN
cord-285806-363ivs67	158	7	IL-6	IL-6	NNP
cord-285806-363ivs67	158	8	,	,	,
cord-285806-363ivs67	158	9	is	be	VBZ
cord-285806-363ivs67	158	10	being	be	VBG
cord-285806-363ivs67	158	11	tested	test	VBN
cord-285806-363ivs67	158	12	in	in	IN
cord-285806-363ivs67	158	13	a	a	DT
cord-285806-363ivs67	158	14	clinical	clinical	JJ
cord-285806-363ivs67	158	15	trial	trial	NN
cord-285806-363ivs67	158	16	against	against	IN
cord-285806-363ivs67	158	17	COVID-19	COVID-19	NNP
cord-285806-363ivs67	158	18	(	(	-LRB-
cord-285806-363ivs67	158	19	Sarilimumab	Sarilimumab	NNP
cord-285806-363ivs67	158	20	COVID-19	COVID-19	NNP
cord-285806-363ivs67	158	21	)	)	-RRB-
cord-285806-363ivs67	158	22	.	.	.
cord-285806-363ivs67	159	1	Another	another	DT
cord-285806-363ivs67	159	2	drug	drug	NN
cord-285806-363ivs67	159	3	that	that	WDT
cord-285806-363ivs67	159	4	showed	show	VBD
cord-285806-363ivs67	159	5	potential	potential	JJ
cord-285806-363ivs67	159	6	inhibition	inhibition	NN
cord-285806-363ivs67	159	7	of	of	IN
cord-285806-363ivs67	159	8	IL-6	IL-6	NNP
cord-285806-363ivs67	159	9	related	related	JJ
cord-285806-363ivs67	159	10	JAK	JAK	NNP
cord-285806-363ivs67	159	11	/	/	SYM
cord-285806-363ivs67	159	12	STAT	stat	NN
cord-285806-363ivs67	159	13	pathway	pathway	NN
cord-285806-363ivs67	159	14	is	be	VBZ
cord-285806-363ivs67	159	15	glatiramer	glatiramer	NNP
cord-285806-363ivs67	159	16	acetate	acetate	NN
cord-285806-363ivs67	159	17	which	which	WDT
cord-285806-363ivs67	159	18	showed	show	VBD
cord-285806-363ivs67	159	19	potential	potential	NN
cord-285806-363ivs67	159	20	to	to	TO
cord-285806-363ivs67	159	21	downregulate	downregulate	VB
cord-285806-363ivs67	159	22	both	both	DT
cord-285806-363ivs67	159	23	IL-17	IL-17	NNP
cord-285806-363ivs67	160	1	and	and	CC
cord-285806-363ivs67	160	2	IL-6	IL-6	NNP
cord-285806-363ivs67	160	3	in	in	IN
cord-285806-363ivs67	160	4	the	the	DT
cord-285806-363ivs67	160	5	central	central	JJ
cord-285806-363ivs67	160	6	nervous	nervous	JJ
cord-285806-363ivs67	160	7	system	system	NN
cord-285806-363ivs67	160	8	in	in	IN
cord-285806-363ivs67	160	9	an	an	DT
cord-285806-363ivs67	160	10	autoimmune	autoimmune	NN
cord-285806-363ivs67	160	11	encephalitis	encephalitis	NN
cord-285806-363ivs67	160	12	98	98	CD
cord-285806-363ivs67	160	13	.	.	.
cord-285806-363ivs67	161	1	Here	here	RB
cord-285806-363ivs67	161	2	the	the	DT
cord-285806-363ivs67	161	3	author	author	NN
cord-285806-363ivs67	161	4	showed	show	VBD
cord-285806-363ivs67	161	5	the	the	DT
cord-285806-363ivs67	161	6	viable	viable	JJ
cord-285806-363ivs67	161	7	options	option	NNS
cord-285806-363ivs67	161	8	against	against	IN
cord-285806-363ivs67	161	9	the	the	DT
cord-285806-363ivs67	161	10	cytokine	cytokine	NN
cord-285806-363ivs67	161	11	storm	storm	NN
cord-285806-363ivs67	161	12	induced	induce	VBN
cord-285806-363ivs67	161	13	by	by	IN
cord-285806-363ivs67	161	14	SARS	SARS	NNP
cord-285806-363ivs67	161	15	-	-	HYPH
cord-285806-363ivs67	161	16	CoV-2	CoV-2	NNP
cord-285806-363ivs67	161	17	,	,	,
cord-285806-363ivs67	161	18	showing	show	VBG
cord-285806-363ivs67	161	19	that	that	IN
cord-285806-363ivs67	161	20	besides	besides	IN
cord-285806-363ivs67	161	21	Tocilizumab	Tocilizumab	NNP
cord-285806-363ivs67	161	22	,	,	,
cord-285806-363ivs67	161	23	other	other	JJ
cord-285806-363ivs67	161	24	options	option	NNS
cord-285806-363ivs67	161	25	must	must	MD
cord-285806-363ivs67	161	26	be	be	VB
cord-285806-363ivs67	161	27	taken	take	VBN
cord-285806-363ivs67	161	28	into	into	IN
cord-285806-363ivs67	161	29	account	account	NN
cord-285806-363ivs67	161	30	,	,	,
cord-285806-363ivs67	161	31	and	and	CC
cord-285806-363ivs67	161	32	that	that	IN
cord-285806-363ivs67	161	33	inhibiting	inhibit	VBG
cord-285806-363ivs67	161	34	IL-6	IL-6	NNP
cord-285806-363ivs67	161	35	is	be	VBZ
cord-285806-363ivs67	161	36	not	not	RB
cord-285806-363ivs67	161	37	a	a	DT
cord-285806-363ivs67	161	38	simple	simple	JJ
cord-285806-363ivs67	161	39	thing	thing	NN
cord-285806-363ivs67	161	40	to	to	TO
cord-285806-363ivs67	161	41	do	do	VB
cord-285806-363ivs67	161	42	,	,	,
cord-285806-363ivs67	161	43	since	since	IN
cord-285806-363ivs67	161	44	it	-PRON-	PRP
cord-285806-363ivs67	161	45	has	have	VBZ
cord-285806-363ivs67	161	46	at	at	RB
cord-285806-363ivs67	161	47	least	least	RBS
cord-285806-363ivs67	161	48	two	two	CD
cord-285806-363ivs67	161	49	different	different	JJ
cord-285806-363ivs67	161	50	and	and	CC
cord-285806-363ivs67	161	51	divergent	divergent	JJ
cord-285806-363ivs67	161	52	pathways	pathway	NNS
cord-285806-363ivs67	161	53	;	;	:
cord-285806-363ivs67	161	54	thus	thus	RB
cord-285806-363ivs67	161	55	suggesting	suggest	VBG
cord-285806-363ivs67	161	56	to	to	TO
cord-285806-363ivs67	161	57	inhibit	inhibit	VB
cord-285806-363ivs67	161	58	only	only	RB
cord-285806-363ivs67	161	59	the	the	DT
cord-285806-363ivs67	161	60	proinflammatory	proinflammatory	JJ
cord-285806-363ivs67	161	61	response	response	NN
cord-285806-363ivs67	161	62	,	,	,
cord-285806-363ivs67	161	63	the	the	DT
cord-285806-363ivs67	161	64	trans	trans	NN
cord-285806-363ivs67	161	65	-	-	HYPH
cord-285806-363ivs67	161	66	signaling	signal	VBG
cord-285806-363ivs67	161	67	transduction	transduction	NN
cord-285806-363ivs67	161	68	with	with	IN
cord-285806-363ivs67	161	69	SGP130Fc	sgp130fc	CD
cord-285806-363ivs67	161	70	,	,	,
cord-285806-363ivs67	161	71	which	which	WDT
cord-285806-363ivs67	161	72	seems	seem	VBZ
cord-285806-363ivs67	161	73	a	a	DT
cord-285806-363ivs67	161	74	more	more	RBR
cord-285806-363ivs67	161	75	reasonable	reasonable	JJ
cord-285806-363ivs67	161	76	choice	choice	NN
cord-285806-363ivs67	161	77	then	then	RB
cord-285806-363ivs67	161	78	inhibiting	inhibit	VBG
cord-285806-363ivs67	161	79	both	both	DT
cord-285806-363ivs67	161	80	pathways	pathway	NNS
cord-285806-363ivs67	161	81	.	.	.
cord-285806-363ivs67	162	1	Here	here	RB
cord-285806-363ivs67	162	2	also	also	RB
cord-285806-363ivs67	162	3	other	other	JJ
cord-285806-363ivs67	162	4	possible	possible	JJ
cord-285806-363ivs67	162	5	choices	choice	NNS
cord-285806-363ivs67	162	6	in	in	IN
cord-285806-363ivs67	162	7	counteracting	counteract	VBG
cord-285806-363ivs67	162	8	IL-6	IL-6	NNP
cord-285806-363ivs67	162	9	mediated	mediate	VBN
cord-285806-363ivs67	162	10	activities	activity	NNS
cord-285806-363ivs67	162	11	are	be	VBP
cord-285806-363ivs67	162	12	shown	show	VBN
cord-285806-363ivs67	162	13	,	,	,
cord-285806-363ivs67	162	14	like	like	IN
cord-285806-363ivs67	162	15	Ruxolitinib	Ruxolitinib	NNP
cord-285806-363ivs67	162	16	and	and	CC
cord-285806-363ivs67	162	17	Baricitnib	Baricitnib	NNP
cord-285806-363ivs67	162	18	,	,	,
cord-285806-363ivs67	162	19	in	in	IN
cord-285806-363ivs67	162	20	the	the	DT
cord-285806-363ivs67	162	21	hope	hope	NN
cord-285806-363ivs67	162	22	to	to	TO
cord-285806-363ivs67	162	23	find	find	VB
cord-285806-363ivs67	162	24	new	new	JJ
cord-285806-363ivs67	162	25	possible	possible	JJ
cord-285806-363ivs67	162	26	strategies	strategy	NNS
cord-285806-363ivs67	162	27	and	and	CC
cord-285806-363ivs67	162	28	discovering	discover	VBG
cord-285806-363ivs67	162	29	new	new	JJ
cord-285806-363ivs67	162	30	properties	property	NNS
cord-285806-363ivs67	162	31	of	of	IN
cord-285806-363ivs67	162	32	the	the	DT
cord-285806-363ivs67	162	33	drugs	drug	NNS
cord-285806-363ivs67	162	34	already	already	RB
cord-285806-363ivs67	162	35	available	available	JJ
cord-285806-363ivs67	162	36	,	,	,
cord-285806-363ivs67	162	37	since	since	IN
cord-285806-363ivs67	162	38	this	this	DT
cord-285806-363ivs67	162	39	would	would	MD
cord-285806-363ivs67	162	40	mean	mean	VB
cord-285806-363ivs67	162	41	accelerating	accelerate	VBG
cord-285806-363ivs67	162	42	clinical	clinical	JJ
cord-285806-363ivs67	162	43	trials	trial	NNS
cord-285806-363ivs67	162	44	as	as	IN
cord-285806-363ivs67	162	45	their	-PRON-	PRP$
cord-285806-363ivs67	162	46	side	side	NN
cord-285806-363ivs67	162	47	effects	effect	NNS
cord-285806-363ivs67	162	48	and	and	CC
cord-285806-363ivs67	162	49	tolerability	tolerability	NN
cord-285806-363ivs67	162	50	in	in	IN
cord-285806-363ivs67	162	51	humans	human	NNS
cord-285806-363ivs67	162	52	are	be	VBP
cord-285806-363ivs67	162	53	already	already	RB
cord-285806-363ivs67	162	54	known	know	VBN
cord-285806-363ivs67	162	55	.	.	.
cord-285806-363ivs67	163	1	Figure1	Figure1	NNP
cord-285806-363ivs67	163	2	.	.	.
cord-285806-363ivs67	164	1	This	this	DT
cord-285806-363ivs67	164	2	diagram	diagram	NN
cord-285806-363ivs67	164	3	shows	show	VBZ
cord-285806-363ivs67	164	4	the	the	DT
cord-285806-363ivs67	164	5	classic	classic	JJ
cord-285806-363ivs67	164	6	signaling	signal	VBG
cord-285806-363ivs67	164	7	pathway	pathway	NN
cord-285806-363ivs67	164	8	(	(	-LRB-
cord-285806-363ivs67	164	9	mediated	mediate	VBN
cord-285806-363ivs67	164	10	by	by	IN
cord-285806-363ivs67	164	11	the	the	DT
cord-285806-363ivs67	164	12	membrane	membrane	NN
cord-285806-363ivs67	164	13	-	-	HYPH
cord-285806-363ivs67	164	14	bound	bind	VBN
cord-285806-363ivs67	164	15	form	form	NN
cord-285806-363ivs67	164	16	of	of	IN
cord-285806-363ivs67	164	17	IL-6	IL-6	NNP
cord-285806-363ivs67	164	18	receptor	receptor	NN
cord-285806-363ivs67	164	19	,	,	,
cord-285806-363ivs67	164	20	mIL6R	mil6r	CD
cord-285806-363ivs67	164	21	)	)	-RRB-
cord-285806-363ivs67	164	22	which	which	WDT
cord-285806-363ivs67	164	23	is	be	VBZ
cord-285806-363ivs67	164	24	believed	believe	VBN
cord-285806-363ivs67	164	25	to	to	TO
cord-285806-363ivs67	164	26	be	be	VB
cord-285806-363ivs67	164	27	the	the	DT
cord-285806-363ivs67	164	28	antiinflammatory	antiinflammatory	JJ
cord-285806-363ivs67	164	29	one	one	CD
cord-285806-363ivs67	164	30	and	and	CC
cord-285806-363ivs67	164	31	the	the	DT
cord-285806-363ivs67	164	32	trans	trans	NN
cord-285806-363ivs67	164	33	-	-	JJ
cord-285806-363ivs67	164	34	signaling	signal	VBG
cord-285806-363ivs67	164	35	pathway	pathway	NN
cord-285806-363ivs67	164	36	(	(	-LRB-
cord-285806-363ivs67	164	37	mediated	mediate	VBN
cord-285806-363ivs67	164	38	by	by	IN
cord-285806-363ivs67	164	39	the	the	DT
cord-285806-363ivs67	164	40	soluble	soluble	JJ
cord-285806-363ivs67	164	41	form	form	NN
cord-285806-363ivs67	164	42	of	of	IN
cord-285806-363ivs67	164	43	IL-6	IL-6	NNP
cord-285806-363ivs67	164	44	receptor	receptor	NN
cord-285806-363ivs67	164	45	,	,	,
cord-285806-363ivs67	164	46	sIL6-R	sIL6-R	''
cord-285806-363ivs67	164	47	)	)	-RRB-
cord-285806-363ivs67	164	48	which	which	WDT
cord-285806-363ivs67	164	49	is	be	VBZ
cord-285806-363ivs67	164	50	believed	believe	VBN
cord-285806-363ivs67	164	51	to	to	TO
cord-285806-363ivs67	164	52	be	be	VB
cord-285806-363ivs67	164	53	the	the	DT
cord-285806-363ivs67	164	54	pro	pro	JJ
cord-285806-363ivs67	164	55	-	-	JJ
cord-285806-363ivs67	164	56	inflammatory	inflammatory	JJ
cord-285806-363ivs67	164	57	one	one	CD
cord-285806-363ivs67	164	58	.	.	.
cord-285806-363ivs67	165	1	Tocilizumab	Tocilizumab	NNP
cord-285806-363ivs67	165	2	inhibits	inhibit	VBZ
cord-285806-363ivs67	165	3	both	both	DT
cord-285806-363ivs67	165	4	of	of	IN
cord-285806-363ivs67	165	5	them	-PRON-	PRP
cord-285806-363ivs67	165	6	,	,	,
cord-285806-363ivs67	165	7	SGP130Fc	SGP130Fc	NNS
cord-285806-363ivs67	165	8	inhibits	inhibit	VBZ
cord-285806-363ivs67	165	9	only	only	RB
cord-285806-363ivs67	165	10	the	the	DT
cord-285806-363ivs67	165	11	trans	trans	NN
cord-285806-363ivs67	165	12	-	-	JJ
cord-285806-363ivs67	165	13	signaling	signal	VBG
cord-285806-363ivs67	165	14	pathway	pathway	NN
cord-285806-363ivs67	165	15	.	.	.
cord-285806-363ivs67	166	1	Coronavirus	Coronavirus	NNP
cord-285806-363ivs67	166	2	pathogenesis	pathogenesis	NN
cord-285806-363ivs67	167	1	The	the	DT
cord-285806-363ivs67	167	2	continuing	continue	VBG
cord-285806-363ivs67	167	3	2019-nCoV	2019-ncov	CD
cord-285806-363ivs67	167	4	epidemic	epidemic	NN
cord-285806-363ivs67	167	5	threat	threat	NN
cord-285806-363ivs67	167	6	of	of	IN
cord-285806-363ivs67	167	7	novel	novel	JJ
cord-285806-363ivs67	167	8	coronaviruses	coronaviruse	NNS
cord-285806-363ivs67	167	9	to	to	IN
cord-285806-363ivs67	167	10	global	global	JJ
cord-285806-363ivs67	167	11	health	health	NN
cord-285806-363ivs67	168	1	-The	-The	:
cord-285806-363ivs67	168	2	latest	late	JJS
cord-285806-363ivs67	168	3	2019	2019	CD
cord-285806-363ivs67	168	4	novel	novel	JJ
cord-285806-363ivs67	168	5	coronavirus	coronavirus	NN
cord-285806-363ivs67	168	6	outbreak	outbreak	NN
cord-285806-363ivs67	168	7	in	in	IN
cord-285806-363ivs67	168	8	Wuhan	Wuhan	NNP
cord-285806-363ivs67	168	9	,	,	,
cord-285806-363ivs67	168	10	China	China	NNP
cord-285806-363ivs67	168	11	2019	2019	CD
cord-285806-363ivs67	168	12	novel	novel	NN
cord-285806-363ivs67	168	13	coronavirus	coronavirus	NN
cord-285806-363ivs67	168	14	of	of	IN
cord-285806-363ivs67	168	15	pneumonia	pneumonia	NN
cord-285806-363ivs67	168	16	in	in	IN
cord-285806-363ivs67	168	17	Wuhan	Wuhan	NNP
cord-285806-363ivs67	168	18	,	,	,
cord-285806-363ivs67	168	19	China	China	NNP
cord-285806-363ivs67	168	20	:	:	:
cord-285806-363ivs67	168	21	emerging	emerge	VBG
cord-285806-363ivs67	168	22	attack	attack	NN
cord-285806-363ivs67	168	23	and	and	CC
cord-285806-363ivs67	168	24	management	management	NN
cord-285806-363ivs67	168	25	strategies	strategy	NNS
cord-285806-363ivs67	168	26	Discovering	discover	VBG
cord-285806-363ivs67	168	27	drugs	drug	NNS
cord-285806-363ivs67	168	28	to	to	TO
cord-285806-363ivs67	168	29	treat	treat	VB
cord-285806-363ivs67	168	30	coronavirus	coronavirus	NN
cord-285806-363ivs67	168	31	disease	disease	NN
cord-285806-363ivs67	168	32	2019	2019	CD
cord-285806-363ivs67	168	33	(	(	-LRB-
cord-285806-363ivs67	168	34	COVID-19	COVID-19	NNP
cord-285806-363ivs67	168	35	)	)	-RRB-
cord-285806-363ivs67	168	36	Compounds	compound	NNS
cord-285806-363ivs67	168	37	with	with	IN
cord-285806-363ivs67	168	38	therapeutic	therapeutic	JJ
cord-285806-363ivs67	168	39	potential	potential	NN
cord-285806-363ivs67	168	40	against	against	IN
cord-285806-363ivs67	168	41	novel	novel	JJ
cord-285806-363ivs67	168	42	respiratory	respiratory	JJ
cord-285806-363ivs67	168	43	2019	2019	CD
cord-285806-363ivs67	168	44	coronavirus	coronavirus	NN
cord-285806-363ivs67	168	45	Broad	Broad	NNP
cord-285806-363ivs67	168	46	-	-	HYPH
cord-285806-363ivs67	168	47	spectrum	spectrum	NN
cord-285806-363ivs67	168	48	antivirals	antiviral	NNS
cord-285806-363ivs67	168	49	for	for	IN
cord-285806-363ivs67	168	50	the	the	DT
cord-285806-363ivs67	168	51	emerging	emerge	VBG
cord-285806-363ivs67	168	52	Middle	Middle	NNP
cord-285806-363ivs67	168	53	East	East	NNP
cord-285806-363ivs67	168	54	respiratory	respiratory	JJ
cord-285806-363ivs67	168	55	syndrome	syndrome	NN
cord-285806-363ivs67	168	56	coronavirus	coronavirus	NN
cord-285806-363ivs67	169	1	Interferon	interferon	NN
cord-285806-363ivs67	169	2	-	-	HYPH
cord-285806-363ivs67	169	3	beta	beta	NN
cord-285806-363ivs67	169	4	and	and	CC
cord-285806-363ivs67	169	5	mycophenolic	mycophenolic	JJ
cord-285806-363ivs67	169	6	acid	acid	NN
cord-285806-363ivs67	169	7	are	be	VBP
cord-285806-363ivs67	169	8	potent	potent	JJ
cord-285806-363ivs67	169	9	inhibitors	inhibitor	NNS
cord-285806-363ivs67	169	10	of	of	IN
cord-285806-363ivs67	169	11	Middle	Middle	NNP
cord-285806-363ivs67	169	12	East	East	NNP
cord-285806-363ivs67	169	13	respiratory	respiratory	JJ
cord-285806-363ivs67	169	14	syndrome	syndrome	NN
cord-285806-363ivs67	169	15	coronavirus	coronavirus	NN
cord-285806-363ivs67	169	16	in	in	IN
cord-285806-363ivs67	169	17	cell	cell	NN
cord-285806-363ivs67	169	18	-	-	HYPH
cord-285806-363ivs67	169	19	based	base	VBN
cord-285806-363ivs67	169	20	assays	assay	NNS
cord-285806-363ivs67	169	21	Treatment	Treatment	NNP
cord-285806-363ivs67	169	22	of	of	IN
cord-285806-363ivs67	169	23	Middle	Middle	NNP
cord-285806-363ivs67	169	24	East	East	NNP
cord-285806-363ivs67	169	25	Respiratory	Respiratory	NNP
cord-285806-363ivs67	169	26	Syndrome	Syndrome	NNP
cord-285806-363ivs67	169	27	with	with	IN
cord-285806-363ivs67	169	28	a	a	DT
cord-285806-363ivs67	169	29	combination	combination	NN
cord-285806-363ivs67	169	30	of	of	IN
cord-285806-363ivs67	169	31	lopinavir	lopinavir	NNS
cord-285806-363ivs67	169	32	-	-	HYPH
cord-285806-363ivs67	169	33	ritonavir	ritonavir	NNS
cord-285806-363ivs67	169	34	and	and	CC
cord-285806-363ivs67	169	35	interferon	interferon	NN
cord-285806-363ivs67	169	36	-	-	HYPH
cord-285806-363ivs67	169	37	beta1b	beta1b	NNP
cord-285806-363ivs67	169	38	(	(	-LRB-
cord-285806-363ivs67	169	39	MIRACLE	MIRACLE	NNP
cord-285806-363ivs67	169	40	trial	trial	NN
cord-285806-363ivs67	169	41	)	)	-RRB-
cord-285806-363ivs67	169	42	:	:	:
cord-285806-363ivs67	170	1	study	study	NN
cord-285806-363ivs67	170	2	protocol	protocol	NN
cord-285806-363ivs67	170	3	for	for	IN
cord-285806-363ivs67	170	4	a	a	DT
cord-285806-363ivs67	170	5	randomized	randomized	JJ
cord-285806-363ivs67	170	6	controlled	control	VBN
cord-285806-363ivs67	170	7	trial	trial	NN
cord-285806-363ivs67	170	8	Comparative	comparative	JJ
cord-285806-363ivs67	170	9	therapeutic	therapeutic	JJ
cord-285806-363ivs67	170	10	efficacy	efficacy	NN
cord-285806-363ivs67	170	11	of	of	IN
cord-285806-363ivs67	170	12	remdesivir	remdesivir	NNP
cord-285806-363ivs67	170	13	and	and	CC
cord-285806-363ivs67	170	14	combination	combination	NN
cord-285806-363ivs67	170	15	lopinavir	lopinavir	NNS
cord-285806-363ivs67	170	16	,	,	,
cord-285806-363ivs67	170	17	ritonavir	ritonavir	NNP
cord-285806-363ivs67	170	18	,	,	,
cord-285806-363ivs67	170	19	and	and	CC
cord-285806-363ivs67	170	20	interferon	interferon	NN
cord-285806-363ivs67	170	21	beta	beta	NN
cord-285806-363ivs67	170	22	against	against	IN
cord-285806-363ivs67	170	23	MERS	MERS	NNP
cord-285806-363ivs67	170	24	-	-	HYPH
cord-285806-363ivs67	170	25	CoV	CoV	NNP
cord-285806-363ivs67	170	26	Clinical	clinical	JJ
cord-285806-363ivs67	170	27	evidence	evidence	NN
cord-285806-363ivs67	170	28	does	do	VBZ
cord-285806-363ivs67	170	29	not	not	RB
cord-285806-363ivs67	170	30	support	support	VB
cord-285806-363ivs67	170	31	corticosteroid	corticosteroid	NN
cord-285806-363ivs67	170	32	treatment	treatment	NN
cord-285806-363ivs67	170	33	for	for	IN
cord-285806-363ivs67	170	34	2019-nCoV	2019-ncov	CD
cord-285806-363ivs67	170	35	lung	lung	NN
cord-285806-363ivs67	170	36	injury	injury	NN
cord-285806-363ivs67	170	37	Risk	Risk	NNP
cord-285806-363ivs67	170	38	Factors	Factors	NNP
cord-285806-363ivs67	170	39	Associated	Associated	NNP
cord-285806-363ivs67	170	40	With	with	IN
cord-285806-363ivs67	170	41	Acute	acute	JJ
cord-285806-363ivs67	170	42	Respiratory	respiratory	JJ
cord-285806-363ivs67	170	43	Distress	Distress	NNP
cord-285806-363ivs67	170	44	Syndrome	Syndrome	NNP
cord-285806-363ivs67	170	45	and	and	CC
cord-285806-363ivs67	170	46	Death	death	NN
cord-285806-363ivs67	170	47	in	in	IN
cord-285806-363ivs67	170	48	Patients	Patients	NNP
cord-285806-363ivs67	170	49	With	with	IN
cord-285806-363ivs67	170	50	Coronavirus	Coronavirus	NNP
cord-285806-363ivs67	170	51	Disease	Disease	NNP
cord-285806-363ivs67	171	1	Recent	recent	JJ
cord-285806-363ivs67	171	2	insights	insight	NNS
cord-285806-363ivs67	171	3	into	into	IN
cord-285806-363ivs67	171	4	targeting	target	VBG
cord-285806-363ivs67	171	5	the	the	DT
cord-285806-363ivs67	171	6	IL-6	IL-6	NNP
cord-285806-363ivs67	171	7	cytokine	cytokine	NN
cord-285806-363ivs67	171	8	family	family	NN
cord-285806-363ivs67	171	9	in	in	IN
cord-285806-363ivs67	171	10	inflammatory	inflammatory	JJ
cord-285806-363ivs67	171	11	diseases	disease	NNS
cord-285806-363ivs67	171	12	and	and	CC
cord-285806-363ivs67	171	13	cancer	cancer	NN
cord-285806-363ivs67	171	14	IL-6	IL-6	NNP
cord-285806-363ivs67	171	15	as	as	IN
cord-285806-363ivs67	171	16	a	a	DT
cord-285806-363ivs67	171	17	keystone	keystone	JJ
cord-285806-363ivs67	171	18	cytokine	cytokine	NN
cord-285806-363ivs67	171	19	in	in	IN
cord-285806-363ivs67	171	20	health	health	NN
cord-285806-363ivs67	171	21	and	and	CC
cord-285806-363ivs67	171	22	disease	disease	NN
cord-285806-363ivs67	172	1	The	the	DT
cord-285806-363ivs67	172	2	cytokine	cytokine	NN
cord-285806-363ivs67	172	3	release	release	NN
cord-285806-363ivs67	172	4	syndrome	syndrome	NN
cord-285806-363ivs67	172	5	(	(	-LRB-
cord-285806-363ivs67	172	6	CRS	CRS	NNP
cord-285806-363ivs67	172	7	)	)	-RRB-
cord-285806-363ivs67	172	8	of	of	IN
cord-285806-363ivs67	172	9	severe	severe	JJ
cord-285806-363ivs67	172	10	Interleukin-6	Interleukin-6	NNP
cord-285806-363ivs67	173	1	receptor	receptor	NN
cord-285806-363ivs67	173	2	(	(	-LRB-
cord-285806-363ivs67	173	3	IL-6R	IL-6R	NNP
cord-285806-363ivs67	173	4	)	)	-RRB-
cord-285806-363ivs67	173	5	antagonist	antagonist	NN
cord-285806-363ivs67	174	1	Tocilizumab	Tocilizumab	NNP
cord-285806-363ivs67	174	2	may	may	MD
cord-285806-363ivs67	174	3	be	be	VB
cord-285806-363ivs67	174	4	the	the	DT
cord-285806-363ivs67	174	5	key	key	NN
cord-285806-363ivs67	174	6	to	to	TO
cord-285806-363ivs67	174	7	reduce	reduce	VB
cord-285806-363ivs67	174	8	the	the	DT
cord-285806-363ivs67	174	9	mortality	mortality	NN
cord-285806-363ivs67	175	1	Interleukin-6	Interleukin-6	NNP
cord-285806-363ivs67	175	2	is	be	VBZ
cord-285806-363ivs67	175	3	crucial	crucial	JJ
cord-285806-363ivs67	175	4	for	for	IN
cord-285806-363ivs67	175	5	recall	recall	NN
cord-285806-363ivs67	175	6	of	of	IN
cord-285806-363ivs67	175	7	influenza	influenza	NN
cord-285806-363ivs67	175	8	-	-	HYPH
cord-285806-363ivs67	175	9	specific	specific	JJ
cord-285806-363ivs67	175	10	memory	memory	NN
cord-285806-363ivs67	175	11	CD4	CD4	NNP
cord-285806-363ivs67	175	12	T	T	NNP
cord-285806-363ivs67	175	13	cells	cell	NNS
cord-285806-363ivs67	175	14	Essential	essential	JJ
cord-285806-363ivs67	175	15	role	role	NN
cord-285806-363ivs67	175	16	of	of	IN
cord-285806-363ivs67	175	17	IL-6	IL-6	NNP
cord-285806-363ivs67	175	18	in	in	IN
cord-285806-363ivs67	175	19	protection	protection	NN
cord-285806-363ivs67	175	20	against	against	IN
cord-285806-363ivs67	175	21	H1N1	H1N1	NNP
cord-285806-363ivs67	175	22	influenza	influenza	NN
cord-285806-363ivs67	175	23	virus	virus	NN
cord-285806-363ivs67	175	24	by	by	IN
cord-285806-363ivs67	175	25	promoting	promote	VBG
cord-285806-363ivs67	175	26	neutrophil	neutrophil	NN
cord-285806-363ivs67	175	27	survival	survival	NN
cord-285806-363ivs67	175	28	in	in	IN
cord-285806-363ivs67	175	29	the	the	DT
cord-285806-363ivs67	175	30	lung	lung	NN
cord-285806-363ivs67	175	31	Interleukin-6	Interleukin-6	NNP
cord-285806-363ivs67	175	32	limits	limit	VBZ
cord-285806-363ivs67	175	33	influenza	influenza	NN
cord-285806-363ivs67	175	34	-	-	HYPH
cord-285806-363ivs67	175	35	induced	induce	VBN
cord-285806-363ivs67	175	36	inflammation	inflammation	NN
cord-285806-363ivs67	175	37	and	and	CC
cord-285806-363ivs67	175	38	protects	protect	VBZ
cord-285806-363ivs67	175	39	against	against	IN
cord-285806-363ivs67	175	40	fatal	fatal	JJ
cord-285806-363ivs67	175	41	lung	lung	NN
cord-285806-363ivs67	175	42	pathology	pathology	NN
cord-285806-363ivs67	175	43	Effect	Effect	NNP
cord-285806-363ivs67	175	44	of	of	IN
cord-285806-363ivs67	175	45	IL-6	IL-6	NNP
cord-285806-363ivs67	175	46	deficiency	deficiency	NN
cord-285806-363ivs67	175	47	on	on	IN
cord-285806-363ivs67	175	48	susceptibility	susceptibility	NN
cord-285806-363ivs67	175	49	to	to	IN
cord-285806-363ivs67	175	50	HSV-1	hsv-1	VB
cord-285806-363ivs67	175	51	respiratory	respiratory	JJ
cord-285806-363ivs67	175	52	infection	infection	NN
cord-285806-363ivs67	175	53	and	and	CC
cord-285806-363ivs67	175	54	intrinsic	intrinsic	JJ
cord-285806-363ivs67	175	55	macrophage	macrophage	NN
cord-285806-363ivs67	175	56	antiviral	antiviral	JJ
cord-285806-363ivs67	175	57	resistance	resistance	NN
cord-285806-363ivs67	176	1	Early	early	RB
cord-285806-363ivs67	176	2	IL-6	IL-6	NNP
cord-285806-363ivs67	176	3	signalling	signalling	NN
cord-285806-363ivs67	176	4	promotes	promote	VBZ
cord-285806-363ivs67	176	5	IL-27	IL-27	NNP
cord-285806-363ivs67	176	6	dependent	dependent	JJ
cord-285806-363ivs67	176	7	maturation	maturation	NN
cord-285806-363ivs67	176	8	of	of	IN
cord-285806-363ivs67	176	9	regulatory	regulatory	JJ
cord-285806-363ivs67	176	10	T	t	NN
cord-285806-363ivs67	176	11	cells	cell	NNS
cord-285806-363ivs67	176	12	in	in	IN
cord-285806-363ivs67	176	13	the	the	DT
cord-285806-363ivs67	176	14	lungs	lung	NNS
cord-285806-363ivs67	176	15	and	and	CC
cord-285806-363ivs67	176	16	resolution	resolution	NN
cord-285806-363ivs67	176	17	of	of	IN
cord-285806-363ivs67	176	18	viral	viral	JJ
cord-285806-363ivs67	176	19	immunopathology	immunopathology	FW
cord-285806-363ivs67	176	20	Temporal	temporal	JJ
cord-285806-363ivs67	176	21	relationship	relationship	NN
cord-285806-363ivs67	176	22	of	of	IN
cord-285806-363ivs67	176	23	viral	viral	JJ
cord-285806-363ivs67	176	24	load	load	NN
cord-285806-363ivs67	176	25	,	,	,
cord-285806-363ivs67	176	26	ribavirin	ribavirin	RB
cord-285806-363ivs67	176	27	,	,	,
cord-285806-363ivs67	176	28	interleukin	interleukin	FW
cord-285806-363ivs67	176	29	(	(	-LRB-
cord-285806-363ivs67	176	30	IL)-6	IL)-6	NNP
cord-285806-363ivs67	176	31	,	,	,
cord-285806-363ivs67	176	32	IL-8	IL-8	NNP
cord-285806-363ivs67	176	33	,	,	,
cord-285806-363ivs67	176	34	and	and	CC
cord-285806-363ivs67	176	35	clinical	clinical	JJ
cord-285806-363ivs67	176	36	progression	progression	NN
cord-285806-363ivs67	176	37	in	in	IN
cord-285806-363ivs67	176	38	patients	patient	NNS
cord-285806-363ivs67	176	39	with	with	IN
cord-285806-363ivs67	176	40	severe	severe	JJ
cord-285806-363ivs67	176	41	acute	acute	JJ
cord-285806-363ivs67	176	42	respiratory	respiratory	JJ
cord-285806-363ivs67	176	43	syndrome	syndrome	NN
cord-285806-363ivs67	176	44	Cytokine	cytokine	NN
cord-285806-363ivs67	176	45	regulation	regulation	NN
cord-285806-363ivs67	176	46	in	in	IN
cord-285806-363ivs67	176	47	SARS	SARS	NNP
cord-285806-363ivs67	176	48	coronavirus	coronavirus	NN
cord-285806-363ivs67	176	49	infection	infection	NN
cord-285806-363ivs67	176	50	compared	compare	VBN
cord-285806-363ivs67	176	51	to	to	IN
cord-285806-363ivs67	176	52	other	other	JJ
cord-285806-363ivs67	176	53	respiratory	respiratory	JJ
cord-285806-363ivs67	176	54	virus	virus	NN
cord-285806-363ivs67	176	55	infections	infection	NNS
cord-285806-363ivs67	176	56	Mouse	mouse	NN
cord-285806-363ivs67	176	57	-	-	HYPH
cord-285806-363ivs67	176	58	passaged	passage	VBN
cord-285806-363ivs67	176	59	severe	severe	JJ
cord-285806-363ivs67	176	60	acute	acute	JJ
cord-285806-363ivs67	176	61	respiratory	respiratory	JJ
cord-285806-363ivs67	176	62	syndromeassociated	syndromeassociate	VBN
cord-285806-363ivs67	176	63	coronavirus	coronavirus	NN
cord-285806-363ivs67	176	64	leads	lead	VBZ
cord-285806-363ivs67	176	65	to	to	IN
cord-285806-363ivs67	176	66	lethal	lethal	JJ
cord-285806-363ivs67	176	67	pulmonary	pulmonary	JJ
cord-285806-363ivs67	176	68	edema	edema	NN
cord-285806-363ivs67	176	69	and	and	CC
cord-285806-363ivs67	176	70	diffuse	diffuse	VB
cord-285806-363ivs67	176	71	alveolar	alveolar	JJ
cord-285806-363ivs67	176	72	damage	damage	NN
cord-285806-363ivs67	176	73	in	in	IN
cord-285806-363ivs67	176	74	adult	adult	NN
cord-285806-363ivs67	176	75	but	but	CC
cord-285806-363ivs67	176	76	not	not	RB
cord-285806-363ivs67	176	77	young	young	JJ
cord-285806-363ivs67	176	78	mice	mouse	NNS
cord-285806-363ivs67	177	1	A	a	DT
cord-285806-363ivs67	177	2	new	new	JJ
cord-285806-363ivs67	177	3	mouse	mouse	NN
cord-285806-363ivs67	177	4	-	-	HYPH
cord-285806-363ivs67	177	5	adapted	adapt	VBN
cord-285806-363ivs67	177	6	strain	strain	NN
cord-285806-363ivs67	177	7	of	of	IN
cord-285806-363ivs67	177	8	SARS	SARS	NNP
cord-285806-363ivs67	177	9	-	-	HYPH
cord-285806-363ivs67	177	10	CoV	CoV	NNP
cord-285806-363ivs67	177	11	as	as	IN
cord-285806-363ivs67	177	12	a	a	DT
cord-285806-363ivs67	177	13	lethal	lethal	JJ
cord-285806-363ivs67	177	14	model	model	NN
cord-285806-363ivs67	177	15	for	for	IN
cord-285806-363ivs67	177	16	evaluating	evaluate	VBG
cord-285806-363ivs67	177	17	antiviral	antiviral	JJ
cord-285806-363ivs67	177	18	agents	agent	NNS
cord-285806-363ivs67	177	19	in	in	IN
cord-285806-363ivs67	177	20	vitro	vitro	FW
cord-285806-363ivs67	177	21	and	and	CC
cord-285806-363ivs67	177	22	in	in	IN
cord-285806-363ivs67	177	23	vivo	vivo	NNP
cord-285806-363ivs67	177	24	Clinical	clinical	JJ
cord-285806-363ivs67	177	25	course	course	NN
cord-285806-363ivs67	177	26	and	and	CC
cord-285806-363ivs67	177	27	risk	risk	NN
cord-285806-363ivs67	177	28	factors	factor	NNS
cord-285806-363ivs67	177	29	for	for	IN
cord-285806-363ivs67	177	30	mortality	mortality	NN
cord-285806-363ivs67	177	31	of	of	IN
cord-285806-363ivs67	177	32	adult	adult	NN
cord-285806-363ivs67	177	33	inpatients	inpatient	NNS
cord-285806-363ivs67	177	34	with	with	IN
cord-285806-363ivs67	177	35	COVID-19	COVID-19	NNP
cord-285806-363ivs67	177	36	in	in	IN
cord-285806-363ivs67	177	37	Wuhan	Wuhan	NNP
cord-285806-363ivs67	177	38	,	,	,
cord-285806-363ivs67	177	39	China	China	NNP
cord-285806-363ivs67	177	40	:	:	:
cord-285806-363ivs67	178	1	a	a	DT
cord-285806-363ivs67	178	2	retrospective	retrospective	JJ
cord-285806-363ivs67	178	3	cohort	cohort	NN
cord-285806-363ivs67	178	4	study	study	NN
cord-285806-363ivs67	178	5	Correlation	Correlation	NNP
cord-285806-363ivs67	178	6	Analysis	Analysis	NNP
cord-285806-363ivs67	178	7	Between	between	IN
cord-285806-363ivs67	178	8	Disease	Disease	NNP
cord-285806-363ivs67	178	9	Severity	Severity	NNP
cord-285806-363ivs67	178	10	and	and	CC
cord-285806-363ivs67	178	11	Inflammationrelated	Inflammationrelated	NNP
cord-285806-363ivs67	178	12	Parameters	Parameters	NNPS
cord-285806-363ivs67	178	13	in	in	IN
cord-285806-363ivs67	178	14	Patients	patient	NNS
cord-285806-363ivs67	178	15	with	with	IN
cord-285806-363ivs67	178	16	Complex	Complex	NNP
cord-285806-363ivs67	178	17	Immune	Immune	NNP
cord-285806-363ivs67	178	18	Dysregulation	Dysregulation	NNP
cord-285806-363ivs67	178	19	in	in	IN
cord-285806-363ivs67	178	20	COVID-19	COVID-19	NNP
cord-285806-363ivs67	178	21	Patients	Patients	NNPS
cord-285806-363ivs67	178	22	with	with	IN
cord-285806-363ivs67	178	23	Severe	severe	JJ
cord-285806-363ivs67	178	24	Respiratory	respiratory	JJ
cord-285806-363ivs67	178	25	Failure	failure	NN
cord-285806-363ivs67	178	26	Identification	identification	NN
cord-285806-363ivs67	178	27	of	of	IN
cord-285806-363ivs67	178	28	oxidative	oxidative	JJ
cord-285806-363ivs67	178	29	stress	stress	NN
cord-285806-363ivs67	178	30	and	and	CC
cord-285806-363ivs67	178	31	Toll	toll	NN
cord-285806-363ivs67	178	32	-	-	HYPH
cord-285806-363ivs67	178	33	like	like	JJ
cord-285806-363ivs67	178	34	receptor	receptor	NN
cord-285806-363ivs67	178	35	4	4	CD
cord-285806-363ivs67	178	36	signaling	signal	VBG
cord-285806-363ivs67	178	37	as	as	IN
cord-285806-363ivs67	178	38	a	a	DT
cord-285806-363ivs67	178	39	key	key	JJ
cord-285806-363ivs67	178	40	pathway	pathway	NN
cord-285806-363ivs67	178	41	of	of	IN
cord-285806-363ivs67	178	42	acute	acute	JJ
cord-285806-363ivs67	178	43	lung	lung	NN
cord-285806-363ivs67	178	44	injury	injury	NN
cord-285806-363ivs67	178	45	A	a	DT
cord-285806-363ivs67	178	46	novel	novel	NN
cord-285806-363ivs67	178	47	TLR4-mediated	tlr4-mediate	VBN
cord-285806-363ivs67	178	48	signaling	signal	VBG
cord-285806-363ivs67	178	49	pathway	pathway	NN
cord-285806-363ivs67	178	50	leading	lead	VBG
cord-285806-363ivs67	178	51	to	to	IN
cord-285806-363ivs67	178	52	IL-6	IL-6	NNP
cord-285806-363ivs67	178	53	responses	response	NNS
cord-285806-363ivs67	178	54	in	in	IN
cord-285806-363ivs67	178	55	human	human	JJ
cord-285806-363ivs67	178	56	bladder	bladder	NN
cord-285806-363ivs67	178	57	epithelial	epithelial	JJ
cord-285806-363ivs67	178	58	cells	cell	NNS
cord-285806-363ivs67	179	1	The	the	DT
cord-285806-363ivs67	179	2	structural	structural	JJ
cord-285806-363ivs67	179	3	basis	basis	NN
cord-285806-363ivs67	179	4	of	of	IN
cord-285806-363ivs67	179	5	lipopolysaccharide	lipopolysaccharide	NN
cord-285806-363ivs67	179	6	recognition	recognition	NN
cord-285806-363ivs67	179	7	by	by	IN
cord-285806-363ivs67	179	8	the	the	DT
cord-285806-363ivs67	179	9	TLR4-MD-2	TLR4-MD-2	NNP
cord-285806-363ivs67	179	10	complex	complex	JJ
cord-285806-363ivs67	179	11	Manipulation	manipulation	NN
cord-285806-363ivs67	179	12	of	of	IN
cord-285806-363ivs67	179	13	the	the	DT
cord-285806-363ivs67	179	14	nuclear	nuclear	JJ
cord-285806-363ivs67	179	15	factor	factor	NN
cord-285806-363ivs67	179	16	-	-	:
cord-285806-363ivs67	179	17	kappaB	kappaB	NNP
cord-285806-363ivs67	179	18	pathway	pathway	NN
cord-285806-363ivs67	179	19	and	and	CC
cord-285806-363ivs67	179	20	the	the	DT
cord-285806-363ivs67	179	21	innate	innate	JJ
cord-285806-363ivs67	179	22	immune	immune	JJ
cord-285806-363ivs67	179	23	response	response	NN
cord-285806-363ivs67	179	24	by	by	IN
cord-285806-363ivs67	179	25	viruses	virus	NNS
cord-285806-363ivs67	179	26	IRFs	IRFs	NNP
cord-285806-363ivs67	179	27	:	:	:
cord-285806-363ivs67	179	28	master	master	NN
cord-285806-363ivs67	179	29	regulators	regulator	NNS
cord-285806-363ivs67	179	30	of	of	IN
cord-285806-363ivs67	179	31	signalling	signal	VBG
cord-285806-363ivs67	179	32	by	by	IN
cord-285806-363ivs67	179	33	Toll	toll	NN
cord-285806-363ivs67	179	34	-	-	HYPH
cord-285806-363ivs67	179	35	like	like	JJ
cord-285806-363ivs67	179	36	receptors	receptor	NNS
cord-285806-363ivs67	179	37	and	and	CC
cord-285806-363ivs67	179	38	cytosolic	cytosolic	JJ
cord-285806-363ivs67	179	39	pattern	pattern	NN
cord-285806-363ivs67	179	40	-	-	HYPH
cord-285806-363ivs67	179	41	recognition	recognition	NN
cord-285806-363ivs67	179	42	receptors	receptor	NNS
cord-285806-363ivs67	179	43	Heritable	heritable	JJ
cord-285806-363ivs67	179	44	defects	defect	NNS
cord-285806-363ivs67	179	45	of	of	IN
cord-285806-363ivs67	179	46	the	the	DT
cord-285806-363ivs67	179	47	human	human	JJ
cord-285806-363ivs67	179	48	TLR	TLR	NNP
cord-285806-363ivs67	179	49	signalling	signal	VBG
cord-285806-363ivs67	179	50	pathways	pathway	NNS
cord-285806-363ivs67	180	1	The	the	DT
cord-285806-363ivs67	180	2	TLR4	TLR4	NNP
cord-285806-363ivs67	180	3	antagonist	antagonist	NN
cord-285806-363ivs67	180	4	Eritoran	Eritoran	NNP
cord-285806-363ivs67	180	5	protects	protect	VBZ
cord-285806-363ivs67	180	6	mice	mouse	NNS
cord-285806-363ivs67	180	7	from	from	IN
cord-285806-363ivs67	180	8	lethal	lethal	JJ
cord-285806-363ivs67	180	9	influenza	influenza	NN
cord-285806-363ivs67	180	10	infection	infection	NN
cord-285806-363ivs67	181	1	TLR4	tlr4	CD
cord-285806-363ivs67	181	2	antagonist	antagonist	NN
cord-285806-363ivs67	181	3	FP7	FP7	NNP
cord-285806-363ivs67	181	4	inhibits	inhibit	VBZ
cord-285806-363ivs67	181	5	LPS	LPS	NNP
cord-285806-363ivs67	181	6	-	-	HYPH
cord-285806-363ivs67	181	7	induced	induce	VBN
cord-285806-363ivs67	181	8	cytokine	cytokine	NN
cord-285806-363ivs67	181	9	production	production	NN
cord-285806-363ivs67	181	10	and	and	CC
cord-285806-363ivs67	181	11	glycolytic	glycolytic	JJ
cord-285806-363ivs67	181	12	reprogramming	reprogramming	NN
cord-285806-363ivs67	181	13	in	in	IN
cord-285806-363ivs67	181	14	dendritic	dendritic	JJ
cord-285806-363ivs67	181	15	cells	cell	NNS
cord-285806-363ivs67	181	16	,	,	,
cord-285806-363ivs67	181	17	and	and	CC
cord-285806-363ivs67	181	18	protects	protect	VBZ
cord-285806-363ivs67	181	19	mice	mouse	NNS
cord-285806-363ivs67	181	20	from	from	IN
cord-285806-363ivs67	181	21	lethal	lethal	JJ
cord-285806-363ivs67	181	22	influenza	influenza	NN
cord-285806-363ivs67	181	23	infection	infection	NN
cord-285806-363ivs67	181	24	TLR4-induced	TLR4-induced	NNP
cord-285806-363ivs67	181	25	NF	NF	NNP
cord-285806-363ivs67	181	26	-	-	HYPH
cord-285806-363ivs67	181	27	kappaB	kappaB	NNP
cord-285806-363ivs67	181	28	and	and	CC
cord-285806-363ivs67	181	29	MAPK	MAPK	NNP
cord-285806-363ivs67	181	30	signaling	signal	VBG
cord-285806-363ivs67	181	31	regulate	regulate	VBP
cord-285806-363ivs67	181	32	the	the	DT
cord-285806-363ivs67	181	33	IL-6	IL-6	NNP
cord-285806-363ivs67	181	34	mRNA	mRNA	NNP
cord-285806-363ivs67	181	35	stabilizing	stabilize	VBG
cord-285806-363ivs67	181	36	protein	protein	NN
cord-285806-363ivs67	181	37	Arid5a	Arid5a	NNP
cord-285806-363ivs67	181	38	Coronavirus	Coronavirus	NNP
cord-285806-363ivs67	181	39	infections	infection	NNS
cord-285806-363ivs67	181	40	and	and	CC
cord-285806-363ivs67	181	41	immune	immune	JJ
cord-285806-363ivs67	181	42	responses	response	NNS
cord-285806-363ivs67	182	1	Nucleocapsid	nucleocapsid	JJ
cord-285806-363ivs67	182	2	protein	protein	NN
cord-285806-363ivs67	182	3	of	of	IN
cord-285806-363ivs67	182	4	SARS	SARS	NNP
cord-285806-363ivs67	182	5	-	-	HYPH
cord-285806-363ivs67	182	6	CoV	CoV	NNP
cord-285806-363ivs67	182	7	activates	activate	VBZ
cord-285806-363ivs67	182	8	interleukin-6	interleukin-6	NNP
cord-285806-363ivs67	182	9	expression	expression	NN
cord-285806-363ivs67	182	10	through	through	IN
cord-285806-363ivs67	182	11	cellular	cellular	JJ
cord-285806-363ivs67	182	12	transcription	transcription	NN
cord-285806-363ivs67	182	13	factor	factor	NN
cord-285806-363ivs67	182	14	NF	NF	NNP
cord-285806-363ivs67	182	15	-	-	HYPH
cord-285806-363ivs67	182	16	kappaB	kappaB	NNP
cord-285806-363ivs67	183	1	The	the	DT
cord-285806-363ivs67	183	2	Role	role	NN
cord-285806-363ivs67	183	3	of	of	IN
cord-285806-363ivs67	183	4	Cytokines	Cytokines	NNPS
cord-285806-363ivs67	183	5	including	include	VBG
cord-285806-363ivs67	183	6	Interleukin-6	Interleukin-6	NNP
cord-285806-363ivs67	183	7	in	in	IN
cord-285806-363ivs67	183	8	COVID-19	COVID-19	NNP
cord-285806-363ivs67	183	9	induced	induce	VBN
cord-285806-363ivs67	183	10	Pneumonia	Pneumonia	NNP
cord-285806-363ivs67	183	11	and	and	CC
cord-285806-363ivs67	183	12	Macrophage	Macrophage	NNP
cord-285806-363ivs67	183	13	Activation	Activation	NNP
cord-285806-363ivs67	183	14	Syndrome	Syndrome	NNP
cord-285806-363ivs67	183	15	-	-	HYPH
cord-285806-363ivs67	183	16	Like	like	JJ
cord-285806-363ivs67	184	1	Disease	Disease	NNP
cord-285806-363ivs67	184	2	Detectable	detectable	JJ
cord-285806-363ivs67	184	3	serum	serum	NN
cord-285806-363ivs67	184	4	SARS	SARS	NNP
cord-285806-363ivs67	184	5	-	-	HYPH
cord-285806-363ivs67	184	6	CoV-2	CoV-2	NNP
cord-285806-363ivs67	184	7	viral	viral	JJ
cord-285806-363ivs67	184	8	load	load	NN
cord-285806-363ivs67	184	9	(	(	-LRB-
cord-285806-363ivs67	184	10	RNAaemia	RNAaemia	NNP
cord-285806-363ivs67	184	11	)	)	-RRB-
cord-285806-363ivs67	184	12	is	be	VBZ
cord-285806-363ivs67	184	13	closely	closely	RB
cord-285806-363ivs67	184	14	associated	associate	VBN
cord-285806-363ivs67	184	15	with	with	IN
cord-285806-363ivs67	184	16	drastically	drastically	RB
cord-285806-363ivs67	184	17	elevated	elevate	VBN
cord-285806-363ivs67	184	18	interleukin	interleukin	NN
cord-285806-363ivs67	184	19	6	6	CD
cord-285806-363ivs67	184	20	(	(	-LRB-
cord-285806-363ivs67	184	21	IL-6	IL-6	NNP
cord-285806-363ivs67	184	22	)	)	-RRB-
cord-285806-363ivs67	184	23	level	level	NN
cord-285806-363ivs67	184	24	in	in	IN
cord-285806-363ivs67	184	25	critically	critically	RB
cord-285806-363ivs67	184	26	ill	ill	JJ
cord-285806-363ivs67	184	27	COVID-19	covid-19	CD
cord-285806-363ivs67	184	28	patients	patient	NNS
cord-285806-363ivs67	185	1	Detectable	detectable	JJ
cord-285806-363ivs67	185	2	2019-nCoV	2019-ncov	CD
cord-285806-363ivs67	185	3	viral	viral	JJ
cord-285806-363ivs67	185	4	RNA	rna	NN
cord-285806-363ivs67	185	5	in	in	IN
cord-285806-363ivs67	185	6	blood	blood	NN
cord-285806-363ivs67	185	7	is	be	VBZ
cord-285806-363ivs67	185	8	a	a	DT
cord-285806-363ivs67	185	9	strong	strong	JJ
cord-285806-363ivs67	185	10	indicator	indicator	NN
cord-285806-363ivs67	185	11	for	for	IN
cord-285806-363ivs67	185	12	the	the	DT
cord-285806-363ivs67	185	13	further	further	JJ
cord-285806-363ivs67	185	14	clinical	clinical	JJ
cord-285806-363ivs67	185	15	severity	severity	NN
cord-285806-363ivs67	185	16	Patient	Patient	NNP
cord-285806-363ivs67	185	17	data	datum	NNS
cord-285806-363ivs67	185	18	,	,	,
cord-285806-363ivs67	185	19	early	early	JJ
cord-285806-363ivs67	185	20	SARS	SARS	NNP
cord-285806-363ivs67	185	21	epidemic	epidemic	NN
cord-285806-363ivs67	185	22	Therapeutic	therapeutic	JJ
cord-285806-363ivs67	185	23	targeting	targeting	NN
cord-285806-363ivs67	185	24	of	of	IN
cord-285806-363ivs67	185	25	the	the	DT
cord-285806-363ivs67	185	26	interleukin-6	interleukin-6	NNP
cord-285806-363ivs67	185	27	receptor	receptor	NN
cord-285806-363ivs67	185	28	Interleukin-6	Interleukin-6	NNP
cord-285806-363ivs67	185	29	and	and	CC
cord-285806-363ivs67	185	30	its	-PRON-	PRP$
cord-285806-363ivs67	185	31	receptors	receptor	NNS
cord-285806-363ivs67	185	32	:	:	:
cord-285806-363ivs67	185	33	a	a	DT
cord-285806-363ivs67	185	34	highly	highly	RB
cord-285806-363ivs67	185	35	regulated	regulated	JJ
cord-285806-363ivs67	185	36	and	and	CC
cord-285806-363ivs67	185	37	dynamic	dynamic	JJ
cord-285806-363ivs67	185	38	system	system	NN
cord-285806-363ivs67	186	1	Interleukin-6	Interleukin-6	NNP
cord-285806-363ivs67	186	2	:	:	:
cord-285806-363ivs67	186	3	Biology	biology	NN
cord-285806-363ivs67	186	4	,	,	,
cord-285806-363ivs67	186	5	signaling	signal	VBG
cord-285806-363ivs67	186	6	and	and	CC
cord-285806-363ivs67	186	7	strategies	strategy	NNS
cord-285806-363ivs67	186	8	of	of	IN
cord-285806-363ivs67	186	9	blockade	blockade	NN
cord-285806-363ivs67	186	10	The	the	DT
cord-285806-363ivs67	186	11	pro	pro	JJ
cord-285806-363ivs67	186	12	-	-	JJ
cord-285806-363ivs67	186	13	and	and	CC
cord-285806-363ivs67	186	14	anti	anti	JJ
cord-285806-363ivs67	186	15	-	-	JJ
cord-285806-363ivs67	186	16	inflammatory	inflammatory	JJ
cord-285806-363ivs67	186	17	properties	property	NNS
cord-285806-363ivs67	186	18	of	of	IN
cord-285806-363ivs67	186	19	the	the	DT
cord-285806-363ivs67	186	20	cytokine	cytokine	NN
cord-285806-363ivs67	186	21	interleukin-6	interleukin-6	NNP
cord-285806-363ivs67	186	22	Generation	generation	NN
cord-285806-363ivs67	186	23	and	and	CC
cord-285806-363ivs67	186	24	function	function	NN
cord-285806-363ivs67	186	25	of	of	IN
cord-285806-363ivs67	186	26	the	the	DT
cord-285806-363ivs67	186	27	soluble	soluble	JJ
cord-285806-363ivs67	186	28	interleukin-6	interleukin-6	NNP
cord-285806-363ivs67	186	29	receptor	receptor	NN
cord-285806-363ivs67	186	30	Proteolytic	Proteolytic	NNP
cord-285806-363ivs67	186	31	Origin	Origin	NNP
cord-285806-363ivs67	186	32	of	of	IN
cord-285806-363ivs67	186	33	the	the	DT
cord-285806-363ivs67	186	34	Soluble	Soluble	NNP
cord-285806-363ivs67	186	35	Human	Human	NNP
cord-285806-363ivs67	187	1	IL-6R	IL-6R	NNP
cord-285806-363ivs67	188	1	In	in	IN
cord-285806-363ivs67	188	2	Vivo	Vivo	NNP
cord-285806-363ivs67	188	3	and	and	CC
cord-285806-363ivs67	188	4	a	a	DT
cord-285806-363ivs67	188	5	Decisive	decisive	JJ
cord-285806-363ivs67	188	6	Role	role	NN
cord-285806-363ivs67	188	7	of	of	IN
cord-285806-363ivs67	188	8	N	N	NNP
cord-285806-363ivs67	188	9	-	-	HYPH
cord-285806-363ivs67	188	10	Glycosylation	Glycosylation	NNP
cord-285806-363ivs67	188	11	Cleavage	cleavage	NN
cord-285806-363ivs67	188	12	Site	site	NN
cord-285806-363ivs67	189	1	Localization	localization	NN
cord-285806-363ivs67	189	2	Differentially	differentially	RB
cord-285806-363ivs67	189	3	Controls	Controls	NNPS
cord-285806-363ivs67	189	4	Interleukin-6	Interleukin-6	NNP
cord-285806-363ivs67	189	5	Receptor	Receptor	NNP
cord-285806-363ivs67	189	6	Proteolysis	Proteolysis	NNP
cord-285806-363ivs67	189	7	by	by	IN
cord-285806-363ivs67	189	8	ADAM10	adam10	NN
cord-285806-363ivs67	189	9	and	and	CC
cord-285806-363ivs67	189	10	ADAM17	adam17	IN
cord-285806-363ivs67	189	11	Isolation	isolation	NN
cord-285806-363ivs67	189	12	of	of	IN
cord-285806-363ivs67	189	13	an	an	DT
cord-285806-363ivs67	189	14	mRNA	mrna	NN
cord-285806-363ivs67	189	15	encoding	encode	VBG
cord-285806-363ivs67	189	16	a	a	DT
cord-285806-363ivs67	189	17	soluble	soluble	JJ
cord-285806-363ivs67	189	18	form	form	NN
cord-285806-363ivs67	189	19	of	of	IN
cord-285806-363ivs67	189	20	the	the	DT
cord-285806-363ivs67	189	21	human	human	JJ
cord-285806-363ivs67	189	22	interleukin-6	interleukin-6	NNP
cord-285806-363ivs67	189	23	receptor	receptor	NN
cord-285806-363ivs67	190	1	The	the	DT
cord-285806-363ivs67	190	2	Soluble	soluble	JJ
cord-285806-363ivs67	190	3	Interleukin	Interleukin	NNP
cord-285806-363ivs67	190	4	6	6	CD
cord-285806-363ivs67	190	5	Receptor	receptor	NN
cord-285806-363ivs67	190	6	:	:	:
cord-285806-363ivs67	190	7	Advanced	Advanced	NNP
cord-285806-363ivs67	190	8	Therapeutic	Therapeutic	NNP
cord-285806-363ivs67	190	9	Options	Options	NNPS
cord-285806-363ivs67	190	10	in	in	IN
cord-285806-363ivs67	190	11	Inflammation	inflammation	NN
cord-285806-363ivs67	190	12	Soluble	soluble	JJ
cord-285806-363ivs67	190	13	receptors	receptor	NNS
cord-285806-363ivs67	190	14	for	for	IN
cord-285806-363ivs67	190	15	cytokines	cytokine	NNS
cord-285806-363ivs67	190	16	and	and	CC
cord-285806-363ivs67	190	17	growth	growth	NN
cord-285806-363ivs67	190	18	factors	factor	NNS
cord-285806-363ivs67	190	19	:	:	:
cord-285806-363ivs67	190	20	generation	generation	NN
cord-285806-363ivs67	190	21	and	and	CC
cord-285806-363ivs67	190	22	biological	biological	JJ
cord-285806-363ivs67	190	23	function	function	NN
cord-285806-363ivs67	190	24	Studies	study	NNS
cord-285806-363ivs67	190	25	on	on	IN
cord-285806-363ivs67	190	26	the	the	DT
cord-285806-363ivs67	190	27	structure	structure	NN
cord-285806-363ivs67	190	28	and	and	CC
cord-285806-363ivs67	190	29	regulation	regulation	NN
cord-285806-363ivs67	190	30	of	of	IN
cord-285806-363ivs67	190	31	the	the	DT
cord-285806-363ivs67	190	32	human	human	JJ
cord-285806-363ivs67	190	33	hepatic	hepatic	JJ
cord-285806-363ivs67	190	34	interleukin-6	interleukin-6	NNP
cord-285806-363ivs67	190	35	receptor	receptor	NN
cord-285806-363ivs67	190	36	Differential	differential	JJ
cord-285806-363ivs67	190	37	expression	expression	NN
cord-285806-363ivs67	190	38	of	of	IN
cord-285806-363ivs67	190	39	CD126	cd126	NN
cord-285806-363ivs67	190	40	and	and	CC
cord-285806-363ivs67	191	1	CD130	CD130	NNP
cord-285806-363ivs67	191	2	mediates	mediate	VBZ
cord-285806-363ivs67	191	3	different	different	JJ
cord-285806-363ivs67	191	4	STAT-3	stat-3	JJ
cord-285806-363ivs67	191	5	phosphorylation	phosphorylation	NN
cord-285806-363ivs67	191	6	in	in	IN
cord-285806-363ivs67	191	7	CD4+CD25-and	CD4+CD25-and	NNP
cord-285806-363ivs67	191	8	CD25high	CD25high	NNP
cord-285806-363ivs67	191	9	regulatory	regulatory	JJ
cord-285806-363ivs67	191	10	T	t	NN
cord-285806-363ivs67	191	11	cells	cell	NNS
cord-285806-363ivs67	192	1	Interleukin-6	Interleukin-6	NNP
cord-285806-363ivs67	192	2	:	:	:
cord-285806-363ivs67	192	3	from	from	IN
cord-285806-363ivs67	192	4	basic	basic	JJ
cord-285806-363ivs67	192	5	biology	biology	NN
cord-285806-363ivs67	192	6	to	to	IN
cord-285806-363ivs67	192	7	selective	selective	JJ
cord-285806-363ivs67	192	8	blockade	blockade	NN
cord-285806-363ivs67	192	9	of	of	IN
cord-285806-363ivs67	192	10	proinflammatory	proinflammatory	JJ
cord-285806-363ivs67	192	11	activities	activity	NNS
cord-285806-363ivs67	193	1	Selective	selective	JJ
cord-285806-363ivs67	193	2	blockade	blockade	NN
cord-285806-363ivs67	193	3	of	of	IN
cord-285806-363ivs67	193	4	interleukin-6	interleukin-6	NNP
cord-285806-363ivs67	193	5	trans	trans	NNP
cord-285806-363ivs67	193	6	-	-	NN
cord-285806-363ivs67	193	7	signaling	signal	VBG
cord-285806-363ivs67	193	8	improves	improve	VBZ
cord-285806-363ivs67	193	9	survival	survival	NN
cord-285806-363ivs67	193	10	in	in	IN
cord-285806-363ivs67	193	11	a	a	DT
cord-285806-363ivs67	193	12	murine	murine	JJ
cord-285806-363ivs67	193	13	polymicrobial	polymicrobial	JJ
cord-285806-363ivs67	193	14	sepsis	sepsis	NN
cord-285806-363ivs67	193	15	model	model	NN
cord-285806-363ivs67	193	16	Transgenic	transgenic	JJ
cord-285806-363ivs67	193	17	blockade	blockade	NN
cord-285806-363ivs67	193	18	of	of	IN
cord-285806-363ivs67	193	19	interleukin	interleukin	NN
cord-285806-363ivs67	194	1	6	6	CD
cord-285806-363ivs67	194	2	transsignaling	transsignaling	NN
cord-285806-363ivs67	194	3	abrogates	abrogate	VBZ
cord-285806-363ivs67	194	4	inflammation	inflammation	NN
cord-285806-363ivs67	195	1	The	the	DT
cord-285806-363ivs67	195	2	IL-6	IL-6	NNP
cord-285806-363ivs67	195	3	/	/	SYM
cord-285806-363ivs67	195	4	sIL-6R	sIL-6R	NNP
cord-285806-363ivs67	195	5	complex	complex	NN
cord-285806-363ivs67	195	6	as	as	IN
cord-285806-363ivs67	195	7	a	a	DT
cord-285806-363ivs67	195	8	novel	novel	JJ
cord-285806-363ivs67	195	9	target	target	NN
cord-285806-363ivs67	195	10	for	for	IN
cord-285806-363ivs67	195	11	therapeutic	therapeutic	JJ
cord-285806-363ivs67	195	12	approaches	approach	NNS
cord-285806-363ivs67	196	1	A	a	DT
cord-285806-363ivs67	196	2	panoramic	panoramic	JJ
cord-285806-363ivs67	196	3	review	review	NN
cord-285806-363ivs67	196	4	of	of	IN
cord-285806-363ivs67	196	5	IL-6	IL-6	NNP
cord-285806-363ivs67	196	6	:	:	:
cord-285806-363ivs67	196	7	Structure	structure	NN
cord-285806-363ivs67	196	8	,	,	,
cord-285806-363ivs67	196	9	pathophysiological	pathophysiological	JJ
cord-285806-363ivs67	196	10	roles	role	NNS
cord-285806-363ivs67	196	11	and	and	CC
cord-285806-363ivs67	196	12	inhibitors	inhibitor	NNS
cord-285806-363ivs67	197	1	IL-6	IL-6	NNP
cord-285806-363ivs67	197	2	trans	trans	NNP
cord-285806-363ivs67	197	3	-	-	HYPH
cord-285806-363ivs67	197	4	signaling	signal	VBG
cord-285806-363ivs67	197	5	promotes	promote	VBZ
cord-285806-363ivs67	197	6	pancreatitis	pancreatitis	NN
cord-285806-363ivs67	197	7	-	-	HYPH
cord-285806-363ivs67	197	8	associated	associate	VBN
cord-285806-363ivs67	197	9	lung	lung	NN
cord-285806-363ivs67	197	10	injury	injury	NN
cord-285806-363ivs67	197	11	and	and	CC
cord-285806-363ivs67	197	12	lethality	lethality	NN
cord-285806-363ivs67	198	1	Transsignaling	Transsignaling	NNP
cord-285806-363ivs67	198	2	of	of	IN
cord-285806-363ivs67	198	3	interleukin-6	interleukin-6	NNP
cord-285806-363ivs67	198	4	crucially	crucially	RB
cord-285806-363ivs67	198	5	contributes	contribute	VBZ
cord-285806-363ivs67	198	6	to	to	IN
cord-285806-363ivs67	198	7	atherosclerosis	atherosclerosis	NN
cord-285806-363ivs67	198	8	in	in	IN
cord-285806-363ivs67	198	9	mice	mouse	NNS
cord-285806-363ivs67	198	10	Serum	serum	NN
cord-285806-363ivs67	198	11	interleukin-6	interleukin-6	NNP
cord-285806-363ivs67	198	12	(	(	-LRB-
cord-285806-363ivs67	198	13	IL-6	IL-6	NNP
cord-285806-363ivs67	198	14	)	)	-RRB-
cord-285806-363ivs67	198	15	and	and	CC
cord-285806-363ivs67	198	16	interleukin-4	interleukin-4	NNP
cord-285806-363ivs67	198	17	(	(	-LRB-
cord-285806-363ivs67	198	18	IL-4	IL-4	NNP
cord-285806-363ivs67	198	19	)	)	-RRB-
cord-285806-363ivs67	199	1	in	in	IN
cord-285806-363ivs67	199	2	patients	patient	NNS
cord-285806-363ivs67	199	3	with	with	IN
cord-285806-363ivs67	199	4	multiple	multiple	JJ
cord-285806-363ivs67	199	5	myeloma	myeloma	NN
cord-285806-363ivs67	199	6	(	(	-LRB-
cord-285806-363ivs67	199	7	MM	MM	NNP
cord-285806-363ivs67	199	8	)	)	-RRB-
cord-285806-363ivs67	199	9	Detection	detection	NN
cord-285806-363ivs67	199	10	of	of	IN
cord-285806-363ivs67	199	11	membrane	membrane	NN
cord-285806-363ivs67	199	12	and	and	CC
cord-285806-363ivs67	199	13	soluble	soluble	JJ
cord-285806-363ivs67	199	14	interleukin-6	interleukin-6	NNP
cord-285806-363ivs67	199	15	receptor	receptor	NN
cord-285806-363ivs67	199	16	in	in	IN
cord-285806-363ivs67	199	17	lymphoid	lymphoid	JJ
cord-285806-363ivs67	199	18	malignancies	malignancy	NNS
cord-285806-363ivs67	200	1	The	the	DT
cord-285806-363ivs67	200	2	IL-6R	IL-6R	NNP
cord-285806-363ivs67	200	3	alpha	alpha	NN
cord-285806-363ivs67	200	4	chain	chain	NN
cord-285806-363ivs67	200	5	controls	control	VBZ
cord-285806-363ivs67	200	6	lung	lung	NNP
cord-285806-363ivs67	200	7	CD4+CD25	CD4+CD25	NNP
cord-285806-363ivs67	200	8	+	+	CC
cord-285806-363ivs67	200	9	Treg	Treg	NNP
cord-285806-363ivs67	200	10	development	development	NN
cord-285806-363ivs67	200	11	and	and	CC
cord-285806-363ivs67	200	12	function	function	NN
cord-285806-363ivs67	200	13	during	during	IN
cord-285806-363ivs67	200	14	allergic	allergic	JJ
cord-285806-363ivs67	200	15	airway	airway	NN
cord-285806-363ivs67	200	16	inflammation	inflammation	NN
cord-285806-363ivs67	200	17	in	in	IN
cord-285806-363ivs67	200	18	vivo	vivo	NNP
cord-285806-363ivs67	200	19	IL-6	IL-6	NNP
cord-285806-363ivs67	200	20	trans	trans	NNP
cord-285806-363ivs67	200	21	-	-	NN
cord-285806-363ivs67	200	22	signaling	signal	VBG
cord-285806-363ivs67	200	23	in	in	IN
cord-285806-363ivs67	200	24	formation	formation	NN
cord-285806-363ivs67	200	25	and	and	CC
cord-285806-363ivs67	200	26	progression	progression	NN
cord-285806-363ivs67	200	27	of	of	IN
cord-285806-363ivs67	200	28	malignant	malignant	JJ
cord-285806-363ivs67	200	29	ascites	ascites	NN
cord-285806-363ivs67	200	30	in	in	IN
cord-285806-363ivs67	200	31	ovarian	ovarian	JJ
cord-285806-363ivs67	200	32	cancer	cancer	NN
cord-285806-363ivs67	200	33	IL-6	IL-6	NNP
cord-285806-363ivs67	200	34	biology	biology	NN
cord-285806-363ivs67	200	35	:	:	:
cord-285806-363ivs67	200	36	implications	implication	NNS
cord-285806-363ivs67	200	37	for	for	IN
cord-285806-363ivs67	200	38	clinical	clinical	JJ
cord-285806-363ivs67	200	39	targeting	targeting	NN
cord-285806-363ivs67	200	40	in	in	IN
cord-285806-363ivs67	200	41	rheumatic	rheumatic	JJ
cord-285806-363ivs67	200	42	disease	disease	NN
cord-285806-363ivs67	201	1	The	the	DT
cord-285806-363ivs67	201	2	IL-6	IL-6	NNP
cord-285806-363ivs67	201	3	/	/	SYM
cord-285806-363ivs67	201	4	gp130	gp130	VBZ
cord-285806-363ivs67	201	5	/	/	SYM
cord-285806-363ivs67	201	6	STAT3	STAT3	NNP
cord-285806-363ivs67	201	7	signaling	signal	VBG
cord-285806-363ivs67	201	8	axis	axis	NN
cord-285806-363ivs67	201	9	:	:	:
cord-285806-363ivs67	201	10	recent	recent	JJ
cord-285806-363ivs67	201	11	advances	advance	NNS
cord-285806-363ivs67	201	12	towards	towards	IN
cord-285806-363ivs67	201	13	specific	specific	JJ
cord-285806-363ivs67	201	14	inhibition	inhibition	NN
cord-285806-363ivs67	202	1	The	the	DT
cord-285806-363ivs67	202	2	interleukin-6	interleukin-6	NNP
cord-285806-363ivs67	202	3	receptor	receptor	NN
cord-285806-363ivs67	203	1	Asp358Ala	asp358ala	UH
cord-285806-363ivs67	204	1	single	single	JJ
cord-285806-363ivs67	204	2	nucleotide	nucleotide	JJ
cord-285806-363ivs67	204	3	polymorphism	polymorphism	NN
cord-285806-363ivs67	204	4	rs2228145	rs2228145	NN
cord-285806-363ivs67	204	5	confers	confer	VBZ
cord-285806-363ivs67	204	6	increased	increase	VBN
cord-285806-363ivs67	204	7	proteolytic	proteolytic	JJ
cord-285806-363ivs67	204	8	conversion	conversion	NN
cord-285806-363ivs67	204	9	rates	rate	NNS
cord-285806-363ivs67	204	10	by	by	IN
cord-285806-363ivs67	204	11	ADAM	ADAM	NNP
cord-285806-363ivs67	204	12	proteases	protease	NNS
cord-285806-363ivs67	205	1	Functional	functional	JJ
cord-285806-363ivs67	205	2	IL6R	IL6R	NNP
cord-285806-363ivs67	205	3	358Ala	358ala	CD
cord-285806-363ivs67	205	4	allele	allele	NN
cord-285806-363ivs67	205	5	impairs	impair	VBZ
cord-285806-363ivs67	205	6	classical	classical	JJ
cord-285806-363ivs67	205	7	IL-6	IL-6	NNP
cord-285806-363ivs67	205	8	receptor	receptor	NN
cord-285806-363ivs67	205	9	signaling	signaling	NN
cord-285806-363ivs67	205	10	and	and	CC
cord-285806-363ivs67	205	11	influences	influence	NNS
cord-285806-363ivs67	205	12	risk	risk	NN
cord-285806-363ivs67	205	13	of	of	IN
cord-285806-363ivs67	205	14	diverse	diverse	JJ
cord-285806-363ivs67	205	15	inflammatory	inflammatory	JJ
cord-285806-363ivs67	205	16	diseases	disease	NNS
cord-285806-363ivs67	206	1	Therapeutic	therapeutic	JJ
cord-285806-363ivs67	206	2	targeting	targeting	NN
cord-285806-363ivs67	206	3	of	of	IN
cord-285806-363ivs67	206	4	interleukin-6	interleukin-6	NNP
cord-285806-363ivs67	206	5	trans	trans	NNP
cord-285806-363ivs67	206	6	-	-	NN
cord-285806-363ivs67	206	7	signaling	signaling	NN
cord-285806-363ivs67	206	8	does	do	VBZ
cord-285806-363ivs67	206	9	not	not	RB
cord-285806-363ivs67	206	10	affect	affect	VB
cord-285806-363ivs67	206	11	the	the	DT
cord-285806-363ivs67	206	12	outcome	outcome	NN
cord-285806-363ivs67	206	13	of	of	IN
cord-285806-363ivs67	206	14	experimental	experimental	JJ
cord-285806-363ivs67	206	15	tuberculosis	tuberculosis	NN
cord-285806-363ivs67	206	16	IL-6	IL-6	NNP
cord-285806-363ivs67	206	17	controls	control	VBZ
cord-285806-363ivs67	206	18	the	the	DT
cord-285806-363ivs67	206	19	innate	innate	JJ
cord-285806-363ivs67	206	20	immune	immune	JJ
cord-285806-363ivs67	206	21	response	response	NN
cord-285806-363ivs67	206	22	against	against	IN
cord-285806-363ivs67	206	23	Listeria	Listeria	NNP
cord-285806-363ivs67	206	24	monocytogenes	monocytogenes	NNP
cord-285806-363ivs67	206	25	via	via	IN
cord-285806-363ivs67	207	1	classical	classical	JJ
cord-285806-363ivs67	207	2	IL-6	IL-6	NNP
cord-285806-363ivs67	207	3	signaling	signal	VBG
cord-285806-363ivs67	207	4	Therapeutic	therapeutic	JJ
cord-285806-363ivs67	207	5	strategies	strategy	NNS
cord-285806-363ivs67	207	6	for	for	IN
cord-285806-363ivs67	207	7	the	the	DT
cord-285806-363ivs67	207	8	clinical	clinical	JJ
cord-285806-363ivs67	207	9	blockade	blockade	NN
cord-285806-363ivs67	207	10	of	of	IN
cord-285806-363ivs67	207	11	IL-6	IL-6	NNP
cord-285806-363ivs67	207	12	/	/	SYM
cord-285806-363ivs67	207	13	gp130	gp130	NNS
cord-285806-363ivs67	207	14	signaling	signal	VBG
cord-285806-363ivs67	207	15	IL-6	IL-6	NNP
cord-285806-363ivs67	207	16	trans	trans	NNP
cord-285806-363ivs67	207	17	-	-	JJ
cord-285806-363ivs67	207	18	signaling	signal	VBG
cord-285806-363ivs67	207	19	modulates	modulate	VBZ
cord-285806-363ivs67	208	1	TLR4-dependent	tlr4-dependent	NN
cord-285806-363ivs67	208	2	inflammatory	inflammatory	JJ
cord-285806-363ivs67	208	3	responses	response	NNS
cord-285806-363ivs67	208	4	via	via	IN
cord-285806-363ivs67	208	5	STAT3	STAT3	NNP
cord-285806-363ivs67	208	6	Cutting	cut	VBG
cord-285806-363ivs67	208	7	edge	edge	NN
cord-285806-363ivs67	208	8	:	:	:
cord-285806-363ivs67	209	1	Inhibition	inhibition	NN
cord-285806-363ivs67	209	2	of	of	IN
cord-285806-363ivs67	209	3	IL-6	IL-6	NNP
cord-285806-363ivs67	209	4	trans	trans	NNP
cord-285806-363ivs67	209	5	-	-	HYPH
cord-285806-363ivs67	209	6	signaling	signal	VBG
cord-285806-363ivs67	209	7	protects	protect	VBZ
cord-285806-363ivs67	209	8	from	from	IN
cord-285806-363ivs67	209	9	malaria	malaria	NN
cord-285806-363ivs67	209	10	-	-	HYPH
cord-285806-363ivs67	209	11	induced	induce	VBN
cord-285806-363ivs67	209	12	lethality	lethality	NN
cord-285806-363ivs67	209	13	in	in	IN
cord-285806-363ivs67	209	14	mice	mouse	NNS
cord-285806-363ivs67	209	15	Role	role	NN
cord-285806-363ivs67	209	16	of	of	IN
cord-285806-363ivs67	209	17	IL-6	IL-6	NNP
cord-285806-363ivs67	209	18	and	and	CC
cord-285806-363ivs67	209	19	its	-PRON-	PRP$
cord-285806-363ivs67	209	20	soluble	soluble	JJ
cord-285806-363ivs67	209	21	receptor	receptor	NN
cord-285806-363ivs67	209	22	in	in	IN
cord-285806-363ivs67	209	23	induction	induction	NN
cord-285806-363ivs67	209	24	of	of	IN
cord-285806-363ivs67	209	25	chemokines	chemokine	NNS
cord-285806-363ivs67	209	26	and	and	CC
cord-285806-363ivs67	209	27	leukocyte	leukocyte	NN
cord-285806-363ivs67	209	28	recruitment	recruitment	NN
cord-285806-363ivs67	209	29	Pathological	pathological	JJ
cord-285806-363ivs67	209	30	findings	finding	NNS
cord-285806-363ivs67	209	31	of	of	IN
cord-285806-363ivs67	209	32	COVID-19	COVID-19	NNP
cord-285806-363ivs67	209	33	associated	associate	VBN
cord-285806-363ivs67	209	34	with	with	IN
cord-285806-363ivs67	209	35	acute	acute	JJ
cord-285806-363ivs67	209	36	respiratory	respiratory	JJ
cord-285806-363ivs67	209	37	distress	distress	NN
cord-285806-363ivs67	209	38	syndrome	syndrome	NN
cord-285806-363ivs67	209	39	Principles	principle	NNS
cord-285806-363ivs67	209	40	of	of	IN
cord-285806-363ivs67	209	41	interleukin	interleukin	NN
cord-285806-363ivs67	209	42	(	(	-LRB-
cord-285806-363ivs67	209	43	IL)-6-type	IL)-6-type	NNP
cord-285806-363ivs67	209	44	cytokine	cytokine	NN
cord-285806-363ivs67	209	45	signalling	signalling	NN
cord-285806-363ivs67	209	46	and	and	CC
cord-285806-363ivs67	209	47	its	-PRON-	PRP$
cord-285806-363ivs67	209	48	regulation	regulation	NN
cord-285806-363ivs67	209	49	Targeting	target	VBG
cord-285806-363ivs67	209	50	the	the	DT
cord-285806-363ivs67	209	51	IL-6	IL-6	NNP
cord-285806-363ivs67	209	52	/	/	SYM
cord-285806-363ivs67	209	53	JAK	JAK	NNP
cord-285806-363ivs67	209	54	/	/	SYM
cord-285806-363ivs67	209	55	STAT3	STAT3	NNP
cord-285806-363ivs67	209	56	signalling	signal	VBG
cord-285806-363ivs67	209	57	axis	axis	NN
cord-285806-363ivs67	209	58	in	in	IN
cord-285806-363ivs67	209	59	cancer	cancer	NN
cord-285806-363ivs67	209	60	Mechanisms	mechanism	NNS
cord-285806-363ivs67	209	61	and	and	CC
cord-285806-363ivs67	209	62	consequences	consequence	NNS
cord-285806-363ivs67	209	63	of	of	IN
cord-285806-363ivs67	209	64	Jak	Jak	NNP
cord-285806-363ivs67	209	65	-	-	HYPH
cord-285806-363ivs67	209	66	STAT	STAT	NNP
cord-285806-363ivs67	209	67	signaling	signal	VBG
cord-285806-363ivs67	209	68	in	in	IN
cord-285806-363ivs67	209	69	the	the	DT
cord-285806-363ivs67	209	70	immune	immune	JJ
cord-285806-363ivs67	209	71	system	system	NN
cord-285806-363ivs67	209	72	Activation	Activation	NNP
cord-285806-363ivs67	209	73	of	of	IN
cord-285806-363ivs67	209	74	the	the	DT
cord-285806-363ivs67	209	75	JAK	JAK	NNP
cord-285806-363ivs67	209	76	/	/	SYM
cord-285806-363ivs67	209	77	STAT3	STAT3	NNP
cord-285806-363ivs67	209	78	and	and	CC
cord-285806-363ivs67	209	79	PI3K	PI3K	NNP
cord-285806-363ivs67	209	80	/	/	SYM
cord-285806-363ivs67	209	81	AKT	AKT	NNP
cord-285806-363ivs67	209	82	pathways	pathway	NNS
cord-285806-363ivs67	209	83	are	be	VBP
cord-285806-363ivs67	209	84	crucial	crucial	JJ
cord-285806-363ivs67	209	85	for	for	IN
cord-285806-363ivs67	209	86	IL-6	IL-6	NNP
cord-285806-363ivs67	209	87	trans	trans	NNP
cord-285806-363ivs67	209	88	-	-	HYPH
cord-285806-363ivs67	209	89	signaling	signal	VBG
cord-285806-363ivs67	209	90	-	-	HYPH
cord-285806-363ivs67	209	91	mediated	mediate	VBN
cord-285806-363ivs67	209	92	pro	pro	JJ
cord-285806-363ivs67	209	93	-	-	JJ
cord-285806-363ivs67	209	94	inflammatory	inflammatory	JJ
cord-285806-363ivs67	209	95	response	response	NN
cord-285806-363ivs67	209	96	in	in	IN
cord-285806-363ivs67	209	97	human	human	JJ
cord-285806-363ivs67	209	98	vascular	vascular	JJ
cord-285806-363ivs67	209	99	endothelial	endothelial	JJ
cord-285806-363ivs67	209	100	cells	cell	NNS
cord-285806-363ivs67	209	101	Safety	safety	NN
cord-285806-363ivs67	209	102	and	and	CC
cord-285806-363ivs67	209	103	efficacy	efficacy	NN
cord-285806-363ivs67	209	104	of	of	IN
cord-285806-363ivs67	209	105	INCB018424	INCB018424	NNP
cord-285806-363ivs67	209	106	,	,	,
cord-285806-363ivs67	209	107	a	a	DT
cord-285806-363ivs67	209	108	JAK1	JAK1	NNP
cord-285806-363ivs67	209	109	and	and	CC
cord-285806-363ivs67	209	110	JAK2	JAK2	NNP
cord-285806-363ivs67	209	111	inhibitor	inhibitor	NN
cord-285806-363ivs67	209	112	,	,	,
cord-285806-363ivs67	209	113	in	in	IN
cord-285806-363ivs67	209	114	myelofibrosis	myelofibrosis	NNP
cord-285806-363ivs67	209	115	Emerging	Emerging	NNP
cord-285806-363ivs67	209	116	treatments	treatment	NNS
cord-285806-363ivs67	209	117	for	for	IN
cord-285806-363ivs67	209	118	classical	classical	JJ
cord-285806-363ivs67	209	119	myeloproliferative	myeloproliferative	JJ
cord-285806-363ivs67	209	120	neoplasms	neoplasm	NNS
cord-285806-363ivs67	209	121	Ruxolitinib	Ruxolitinib	NNP
cord-285806-363ivs67	209	122	,	,	,
cord-285806-363ivs67	209	123	a	a	DT
cord-285806-363ivs67	209	124	selective	selective	JJ
cord-285806-363ivs67	209	125	JAK1	JAK1	NNP
cord-285806-363ivs67	209	126	and	and	CC
cord-285806-363ivs67	209	127	JAK2	JAK2	NNP
cord-285806-363ivs67	209	128	inhibitor	inhibitor	NN
cord-285806-363ivs67	209	129	for	for	IN
cord-285806-363ivs67	209	130	the	the	DT
cord-285806-363ivs67	209	131	treatment	treatment	NN
cord-285806-363ivs67	209	132	of	of	IN
cord-285806-363ivs67	209	133	myeloproliferative	myeloproliferative	JJ
cord-285806-363ivs67	209	134	neoplasms	neoplasm	NNS
cord-285806-363ivs67	209	135	and	and	CC
cord-285806-363ivs67	209	136	psoriasis	psoriasis	NN
cord-285806-363ivs67	209	137	Preclinical	preclinical	JJ
cord-285806-363ivs67	209	138	characterization	characterization	NN
cord-285806-363ivs67	209	139	of	of	IN
cord-285806-363ivs67	209	140	the	the	DT
cord-285806-363ivs67	209	141	selective	selective	JJ
cord-285806-363ivs67	209	142	JAK1/2	JAK1/2	NNP
cord-285806-363ivs67	209	143	inhibitor	inhibitor	NN
cord-285806-363ivs67	209	144	INCB018424	incb018424	IN
cord-285806-363ivs67	209	145	:	:	:
cord-285806-363ivs67	209	146	therapeutic	therapeutic	JJ
cord-285806-363ivs67	209	147	implications	implication	NNS
cord-285806-363ivs67	209	148	for	for	IN
cord-285806-363ivs67	209	149	the	the	DT
cord-285806-363ivs67	209	150	treatment	treatment	NN
cord-285806-363ivs67	209	151	of	of	IN
cord-285806-363ivs67	209	152	myeloproliferative	myeloproliferative	JJ
cord-285806-363ivs67	209	153	neoplasms	neoplasm	NNS
cord-285806-363ivs67	210	1	The	the	DT
cord-285806-363ivs67	210	2	impact	impact	NN
cord-285806-363ivs67	210	3	of	of	IN
cord-285806-363ivs67	210	4	ruxolitinib	ruxolitinib	JJ
cord-285806-363ivs67	210	5	treatment	treatment	NN
cord-285806-363ivs67	210	6	on	on	IN
cord-285806-363ivs67	210	7	inflammation	inflammation	NN
cord-285806-363ivs67	210	8	-	-	HYPH
cord-285806-363ivs67	210	9	mediated	mediate	VBN
cord-285806-363ivs67	210	10	comorbidities	comorbiditie	NNS
cord-285806-363ivs67	210	11	in	in	IN
cord-285806-363ivs67	210	12	myelofibrosis	myelofibrosis	NN
cord-285806-363ivs67	210	13	and	and	CC
cord-285806-363ivs67	210	14	related	relate	VBN
cord-285806-363ivs67	210	15	neoplasms	neoplasm	NNS
cord-285806-363ivs67	210	16	Therapeutic	therapeutic	JJ
cord-285806-363ivs67	210	17	effect	effect	NN
cord-285806-363ivs67	210	18	of	of	IN
cord-285806-363ivs67	210	19	JAK1/2	JAK1/2	NNP
cord-285806-363ivs67	210	20	blockade	blockade	VB
cord-285806-363ivs67	210	21	on	on	IN
cord-285806-363ivs67	210	22	the	the	DT
cord-285806-363ivs67	210	23	manifestations	manifestation	NNS
cord-285806-363ivs67	210	24	of	of	IN
cord-285806-363ivs67	210	25	hemophagocytic	hemophagocytic	JJ
cord-285806-363ivs67	210	26	lymphohistiocytosis	lymphohistiocytosis	NNP
cord-285806-363ivs67	210	27	in	in	IN
cord-285806-363ivs67	210	28	mice	mice	NNP
cord-285806-363ivs67	210	29	COVID-19	COVID-19	NNP
cord-285806-363ivs67	210	30	:	:	:
cord-285806-363ivs67	210	31	consider	consider	VB
cord-285806-363ivs67	210	32	cytokine	cytokine	JJ
cord-285806-363ivs67	210	33	storm	storm	NN
cord-285806-363ivs67	210	34	syndromes	syndrome	NNS
cord-285806-363ivs67	210	35	and	and	CC
cord-285806-363ivs67	210	36	immunosuppression	immunosuppression	NN
cord-285806-363ivs67	210	37	Repression	repression	NN
cord-285806-363ivs67	210	38	of	of	IN
cord-285806-363ivs67	210	39	interferon	interferon	NN
cord-285806-363ivs67	210	40	betaregulated	betaregulate	VBN
cord-285806-363ivs67	210	41	cytokines	cytokine	NNS
cord-285806-363ivs67	210	42	by	by	IN
cord-285806-363ivs67	210	43	the	the	DT
cord-285806-363ivs67	210	44	JAK1/2	JAK1/2	NNP
cord-285806-363ivs67	210	45	inhibitor	inhibitor	NN
cord-285806-363ivs67	210	46	ruxolitinib	ruxolitinib	NN
cord-285806-363ivs67	210	47	in	in	IN
cord-285806-363ivs67	210	48	inflammatory	inflammatory	JJ
cord-285806-363ivs67	210	49	human	human	JJ
cord-285806-363ivs67	210	50	macrophages	macrophage	NNS
cord-285806-363ivs67	210	51	COVID-19	covid-19	VB
cord-285806-363ivs67	210	52	:	:	:
cord-285806-363ivs67	210	53	combining	combine	VBG
cord-285806-363ivs67	210	54	antiviral	antiviral	JJ
cord-285806-363ivs67	210	55	and	and	CC
cord-285806-363ivs67	210	56	anti	anti	JJ
cord-285806-363ivs67	210	57	-	-	JJ
cord-285806-363ivs67	210	58	inflammatory	inflammatory	JJ
cord-285806-363ivs67	210	59	treatments	treatment	NNS
cord-285806-363ivs67	210	60	.	.	.
cord-285806-363ivs67	211	1	The	the	DT
cord-285806-363ivs67	211	2	Lancet	Lancet	NNP
cord-285806-363ivs67	211	3	Infectious	Infectious	NNP
cord-285806-363ivs67	211	4	Diseases	Diseases	NNPS
cord-285806-363ivs67	211	5	Baricitinib	Baricitinib	NNP
cord-285806-363ivs67	211	6	-	-	HYPH
cord-285806-363ivs67	211	7	induced	induce	VBN
cord-285806-363ivs67	211	8	blockade	blockade	NN
cord-285806-363ivs67	211	9	of	of	IN
cord-285806-363ivs67	211	10	interferon	interferon	NN
cord-285806-363ivs67	211	11	gamma	gamma	NN
cord-285806-363ivs67	211	12	receptor	receptor	NN
cord-285806-363ivs67	211	13	and	and	CC
cord-285806-363ivs67	211	14	interleukin-6	interleukin-6	NNP
cord-285806-363ivs67	211	15	receptor	receptor	NN
cord-285806-363ivs67	211	16	for	for	IN
cord-285806-363ivs67	211	17	the	the	DT
cord-285806-363ivs67	211	18	prevention	prevention	NN
cord-285806-363ivs67	211	19	and	and	CC
cord-285806-363ivs67	211	20	treatment	treatment	NN
cord-285806-363ivs67	211	21	of	of	IN
cord-285806-363ivs67	211	22	graft	graft	NN
cord-285806-363ivs67	211	23	-	-	HYPH
cord-285806-363ivs67	211	24	versus	versus	IN
cord-285806-363ivs67	211	25	-	-	HYPH
cord-285806-363ivs67	211	26	host	host	NN
cord-285806-363ivs67	211	27	disease	disease	NN
cord-285806-363ivs67	211	28	Anticancer	Anticancer	NNP
cord-285806-363ivs67	211	29	kinase	kinase	NN
cord-285806-363ivs67	211	30	inhibitors	inhibitor	NNS
cord-285806-363ivs67	211	31	impair	impair	VBP
cord-285806-363ivs67	211	32	intracellular	intracellular	JJ
cord-285806-363ivs67	211	33	viral	viral	JJ
cord-285806-363ivs67	211	34	trafficking	trafficking	NN
cord-285806-363ivs67	211	35	and	and	CC
cord-285806-363ivs67	211	36	exert	exert	VB
cord-285806-363ivs67	211	37	broad	broad	JJ
cord-285806-363ivs67	211	38	-	-	HYPH
cord-285806-363ivs67	211	39	spectrum	spectrum	NN
cord-285806-363ivs67	211	40	antiviral	antiviral	JJ
cord-285806-363ivs67	211	41	effects	effect	NNS
cord-285806-363ivs67	211	42	Sarilumab	Sarilumab	NNP
cord-285806-363ivs67	211	43	for	for	IN
cord-285806-363ivs67	211	44	the	the	DT
cord-285806-363ivs67	211	45	treatment	treatment	NN
cord-285806-363ivs67	211	46	of	of	IN
cord-285806-363ivs67	211	47	ankylosing	ankylose	VBG
cord-285806-363ivs67	211	48	spondylitis	spondylitis	NN
cord-285806-363ivs67	211	49	:	:	:
cord-285806-363ivs67	211	50	results	result	NNS
cord-285806-363ivs67	211	51	of	of	IN
cord-285806-363ivs67	211	52	a	a	DT
cord-285806-363ivs67	211	53	Phase	Phase	NNP
cord-285806-363ivs67	211	54	II	II	NNP
cord-285806-363ivs67	211	55	,	,	,
cord-285806-363ivs67	211	56	randomised	randomised	JJ
cord-285806-363ivs67	211	57	,	,	,
cord-285806-363ivs67	211	58	double	double	JJ
cord-285806-363ivs67	211	59	-	-	HYPH
cord-285806-363ivs67	211	60	blind	blind	JJ
cord-285806-363ivs67	211	61	,	,	,
cord-285806-363ivs67	211	62	placebo	placebo	NN
cord-285806-363ivs67	211	63	-	-	HYPH
cord-285806-363ivs67	211	64	controlled	control	VBN
cord-285806-363ivs67	211	65	study	study	NN
cord-285806-363ivs67	211	66	(	(	-LRB-
cord-285806-363ivs67	211	67	ALIGN	ALIGN	NNP
cord-285806-363ivs67	211	68	)	)	-RRB-
cord-285806-363ivs67	212	1	Sirukumab	Sirukumab	NNP
cord-285806-363ivs67	212	2	,	,	,
cord-285806-363ivs67	212	3	a	a	DT
cord-285806-363ivs67	212	4	human	human	JJ
cord-285806-363ivs67	212	5	anti	anti	NN
cord-285806-363ivs67	212	6	-	-	JJ
cord-285806-363ivs67	212	7	interleukin-6	interleukin-6	JJ
cord-285806-363ivs67	212	8	monoclonal	monoclonal	JJ
cord-285806-363ivs67	212	9	antibody	antibody	NN
cord-285806-363ivs67	212	10	:	:	:
cord-285806-363ivs67	212	11	a	a	DT
cord-285806-363ivs67	212	12	randomised	randomised	JJ
cord-285806-363ivs67	212	13	,	,	,
cord-285806-363ivs67	212	14	2-part	2-part	CD
cord-285806-363ivs67	212	15	(	(	-LRB-
cord-285806-363ivs67	212	16	proof	proof	NN
cord-285806-363ivs67	212	17	-	-	HYPH
cord-285806-363ivs67	212	18	of	of	IN
cord-285806-363ivs67	212	19	-	-	HYPH
cord-285806-363ivs67	212	20	concept	concept	NN
cord-285806-363ivs67	212	21	and	and	CC
cord-285806-363ivs67	212	22	dose	dose	NN
cord-285806-363ivs67	212	23	-	-	HYPH
cord-285806-363ivs67	212	24	finding	finding	NN
cord-285806-363ivs67	212	25	)	)	-RRB-
cord-285806-363ivs67	212	26	,	,	,
cord-285806-363ivs67	212	27	phase	phase	NN
cord-285806-363ivs67	212	28	II	ii	CD
cord-285806-363ivs67	212	29	study	study	NN
cord-285806-363ivs67	212	30	in	in	IN
cord-285806-363ivs67	212	31	patients	patient	NNS
cord-285806-363ivs67	212	32	with	with	IN
cord-285806-363ivs67	212	33	active	active	JJ
cord-285806-363ivs67	212	34	rheumatoid	rheumatoid	NN
cord-285806-363ivs67	212	35	arthritis	arthritis	NN
cord-285806-363ivs67	212	36	despite	despite	IN
cord-285806-363ivs67	212	37	methotrexate	methotrexate	NNP
cord-285806-363ivs67	212	38	therapy	therapy	NNP
cord-285806-363ivs67	212	39	Randomized	Randomized	NNP
cord-285806-363ivs67	212	40	,	,	,
cord-285806-363ivs67	212	41	Double	double	JJ
cord-285806-363ivs67	212	42	-	-	HYPH
cord-285806-363ivs67	212	43	Blind	blind	JJ
cord-285806-363ivs67	212	44	,	,	,
cord-285806-363ivs67	212	45	Placebo	Placebo	NNP
cord-285806-363ivs67	212	46	-	-	HYPH
cord-285806-363ivs67	212	47	Controlled	Controlled	NNP
cord-285806-363ivs67	212	48	Study	Study	NNP
cord-285806-363ivs67	212	49	to	to	TO
cord-285806-363ivs67	212	50	Evaluate	evaluate	VB
cord-285806-363ivs67	212	51	the	the	DT
cord-285806-363ivs67	212	52	Efficacy	Efficacy	NNP
cord-285806-363ivs67	212	53	and	and	CC
cord-285806-363ivs67	212	54	Safety	Safety	NNP
cord-285806-363ivs67	212	55	of	of	IN
cord-285806-363ivs67	212	56	Treatment	Treatment	NNP
cord-285806-363ivs67	212	57	With	with	IN
cord-285806-363ivs67	212	58	Sirukumab	Sirukumab	NNP
cord-285806-363ivs67	212	59	(	(	-LRB-
cord-285806-363ivs67	212	60	CNTO	CNTO	NNP
cord-285806-363ivs67	212	61	136	136	CD
cord-285806-363ivs67	212	62	)	)	-RRB-
cord-285806-363ivs67	212	63	in	in	IN
cord-285806-363ivs67	212	64	Patients	patient	NNS
cord-285806-363ivs67	212	65	With	with	IN
cord-285806-363ivs67	212	66	Active	active	JJ
cord-285806-363ivs67	212	67	Lupus	Lupus	NNP
cord-285806-363ivs67	212	68	Nephritis	nephritis	NN
cord-285806-363ivs67	213	1	The	the	DT
cord-285806-363ivs67	213	2	efficacy	efficacy	NN
cord-285806-363ivs67	213	3	and	and	CC
cord-285806-363ivs67	213	4	safety	safety	NN
cord-285806-363ivs67	213	5	of	of	IN
cord-285806-363ivs67	213	6	subcutaneous	subcutaneous	JJ
cord-285806-363ivs67	213	7	clazakizumab	clazakizumab	NNS
cord-285806-363ivs67	213	8	in	in	IN
cord-285806-363ivs67	213	9	patients	patient	NNS
cord-285806-363ivs67	213	10	with	with	IN
cord-285806-363ivs67	213	11	moderate	moderate	JJ
cord-285806-363ivs67	213	12	-	-	HYPH
cord-285806-363ivs67	213	13	to	to	IN
cord-285806-363ivs67	213	14	-	-	HYPH
cord-285806-363ivs67	213	15	severe	severe	JJ
cord-285806-363ivs67	213	16	rheumatoid	rheumatoid	NN
cord-285806-363ivs67	213	17	arthritis	arthritis	NN
cord-285806-363ivs67	213	18	and	and	CC
cord-285806-363ivs67	213	19	an	an	DT
cord-285806-363ivs67	213	20	inadequate	inadequate	JJ
cord-285806-363ivs67	213	21	response	response	NN
cord-285806-363ivs67	213	22	to	to	IN
cord-285806-363ivs67	213	23	methotrexate	methotrexate	NN
cord-285806-363ivs67	213	24	:	:	:
cord-285806-363ivs67	213	25	results	result	NNS
cord-285806-363ivs67	213	26	from	from	IN
cord-285806-363ivs67	213	27	a	a	DT
cord-285806-363ivs67	213	28	multinational	multinational	JJ
cord-285806-363ivs67	213	29	,	,	,
cord-285806-363ivs67	213	30	phase	phase	NN
cord-285806-363ivs67	213	31	IIb	IIb	NNP
cord-285806-363ivs67	213	32	,	,	,
cord-285806-363ivs67	213	33	randomized	randomized	JJ
cord-285806-363ivs67	213	34	,	,	,
cord-285806-363ivs67	213	35	double	double	JJ
cord-285806-363ivs67	213	36	-	-	HYPH
cord-285806-363ivs67	213	37	blind	blind	JJ
cord-285806-363ivs67	213	38	,	,	,
cord-285806-363ivs67	213	39	placebo	placebo	NN
cord-285806-363ivs67	213	40	/	/	SYM
cord-285806-363ivs67	213	41	active	active	JJ
cord-285806-363ivs67	213	42	-	-	HYPH
cord-285806-363ivs67	213	43	controlled	control	VBN
cord-285806-363ivs67	213	44	,	,	,
cord-285806-363ivs67	213	45	dose	dose	NN
cord-285806-363ivs67	213	46	-	-	HYPH
cord-285806-363ivs67	213	47	ranging	range	VBG
cord-285806-363ivs67	213	48	study	study	NN
cord-285806-363ivs67	213	49	Randomised	randomised	JJ
cord-285806-363ivs67	213	50	trial	trial	NN
cord-285806-363ivs67	213	51	and	and	CC
cord-285806-363ivs67	213	52	open	open	JJ
cord-285806-363ivs67	213	53	-	-	HYPH
cord-285806-363ivs67	213	54	label	label	NN
cord-285806-363ivs67	213	55	extension	extension	NN
cord-285806-363ivs67	213	56	study	study	NN
cord-285806-363ivs67	213	57	of	of	IN
cord-285806-363ivs67	213	58	an	an	DT
cord-285806-363ivs67	213	59	antiinterleukin-6	antiinterleukin-6	NNP
cord-285806-363ivs67	213	60	antibody	antibody	NN
cord-285806-363ivs67	213	61	in	in	IN
cord-285806-363ivs67	213	62	Crohn	Crohn	NNP
cord-285806-363ivs67	213	63	's	's	POS
cord-285806-363ivs67	213	64	disease	disease	NN
cord-285806-363ivs67	214	1	(	(	-LRB-
cord-285806-363ivs67	214	2	ANDANTE	ANDANTE	NNP
cord-285806-363ivs67	214	3	I	I	NNP
cord-285806-363ivs67	214	4	and	and	CC
cord-285806-363ivs67	214	5	II	II	NNP
cord-285806-363ivs67	214	6	)	)	-RRB-
cord-285806-363ivs67	215	1	Pharmacokinetics	Pharmacokinetics	NNP
cord-285806-363ivs67	215	2	and	and	CC
cord-285806-363ivs67	215	3	C	C	NNP
cord-285806-363ivs67	215	4	-	-	HYPH
cord-285806-363ivs67	215	5	reactive	reactive	JJ
cord-285806-363ivs67	215	6	protein	protein	NN
cord-285806-363ivs67	215	7	modelling	modelling	NN
cord-285806-363ivs67	215	8	of	of	IN
cord-285806-363ivs67	215	9	anti	anti	JJ
cord-285806-363ivs67	215	10	-	-	JJ
cord-285806-363ivs67	215	11	interleukin-6	interleukin-6	JJ
cord-285806-363ivs67	215	12	PF-04236921	PF-04236921	NNS
cord-285806-363ivs67	215	13	)	)	-RRB-
cord-285806-363ivs67	215	14	in	in	IN
cord-285806-363ivs67	215	15	healthy	healthy	JJ
cord-285806-363ivs67	215	16	volunteers	volunteer	NNS
cord-285806-363ivs67	215	17	and	and	CC
cord-285806-363ivs67	215	18	patients	patient	NNS
cord-285806-363ivs67	215	19	with	with	IN
cord-285806-363ivs67	215	20	autoimmune	autoimmune	JJ
cord-285806-363ivs67	215	21	disease	disease	NN
cord-285806-363ivs67	215	22	Downregulation	Downregulation	NNP
cord-285806-363ivs67	215	23	of	of	IN
cord-285806-363ivs67	215	24	IL-17	IL-17	NNP
cord-285806-363ivs67	215	25	and	and	CC
cord-285806-363ivs67	215	26	IL-6	IL-6	NNP
cord-285806-363ivs67	215	27	in	in	IN
cord-285806-363ivs67	215	28	the	the	DT
cord-285806-363ivs67	215	29	central	central	JJ
cord-285806-363ivs67	215	30	nervous	nervous	JJ
cord-285806-363ivs67	215	31	system	system	NN
cord-285806-363ivs67	215	32	by	by	IN
cord-285806-363ivs67	215	33	glatiramer	glatiramer	NNP
cord-285806-363ivs67	215	34	acetate	acetate	NN
cord-285806-363ivs67	215	35	in	in	IN
cord-285806-363ivs67	215	36	experimental	experimental	JJ
cord-285806-363ivs67	215	37	autoimmune	autoimmune	JJ
cord-285806-363ivs67	215	38	encephalomyelitis	encephalomyelitis	NN
cord-285806-363ivs67	215	39	☒	☒	.
cord-285806-363ivs67	216	1	The	the	DT
cord-285806-363ivs67	216	2	authors	author	NNS
cord-285806-363ivs67	216	3	declare	declare	VBP
cord-285806-363ivs67	216	4	that	that	IN
cord-285806-363ivs67	216	5	they	-PRON-	PRP
cord-285806-363ivs67	216	6	have	have	VBP
cord-285806-363ivs67	216	7	no	no	DT
cord-285806-363ivs67	216	8	known	know	VBN
cord-285806-363ivs67	216	9	competing	compete	VBG
cord-285806-363ivs67	216	10	financial	financial	JJ
cord-285806-363ivs67	216	11	interests	interest	NNS
cord-285806-363ivs67	216	12	or	or	CC
cord-285806-363ivs67	216	13	personal	personal	JJ
cord-285806-363ivs67	216	14	relationships	relationship	NNS
cord-285806-363ivs67	216	15	that	that	WDT
cord-285806-363ivs67	216	16	could	could	MD
cord-285806-363ivs67	216	17	have	have	VB
cord-285806-363ivs67	216	18	appeared	appear	VBN
cord-285806-363ivs67	216	19	to	to	TO
cord-285806-363ivs67	216	20	influence	influence	VB
cord-285806-363ivs67	216	21	the	the	DT
cord-285806-363ivs67	216	22	work	work	NN
cord-285806-363ivs67	217	1	☐	☐	NNP
cord-285806-363ivs67	218	1	The	the	DT
cord-285806-363ivs67	218	2	authors	author	NNS
cord-285806-363ivs67	218	3	declare	declare	VBP
cord-285806-363ivs67	218	4	the	the	DT
cord-285806-363ivs67	218	5	following	follow	VBG
cord-285806-363ivs67	218	6	financial	financial	JJ
cord-285806-363ivs67	218	7	interests	interest	NNS
cord-285806-363ivs67	218	8	/	/	SYM
cord-285806-363ivs67	218	9	personal	personal	JJ
cord-285806-363ivs67	218	10	relationships	relationship	NNS
cord-285806-363ivs67	218	11	which	which	WDT
cord-285806-363ivs67	218	12	may	may	MD
cord-285806-363ivs67	218	13	be	be	VB
cord-285806-363ivs67	218	14	considered	consider	VBN
cord-285806-363ivs67	218	15	as	as	IN
cord-285806-363ivs67	218	16	potential	potential	JJ
cord-285806-363ivs67	218	17	competing	compete	VBG
cord-285806-363ivs67	218	18	interests	interest	NNS
cord-285806-363ivs67	218	19	:	:	:
cord-285806-363ivs67	218	20			NFP
cord-285806-363ivs67	218	21	Evidence	evidence	NN
cord-285806-363ivs67	218	22	of	of	IN
cord-285806-363ivs67	218	23	a	a	DT
cord-285806-363ivs67	218	24	role	role	NN
cord-285806-363ivs67	218	25	for	for	IN
cord-285806-363ivs67	218	26	IL-6	IL-6	NNP
cord-285806-363ivs67	218	27	in	in	IN
cord-285806-363ivs67	218	28	the	the	DT
cord-285806-363ivs67	218	29	pathology	pathology	NN
cord-285806-363ivs67	218	30	of	of	IN
cord-285806-363ivs67	218	31	SARS	SARS	NNP
cord-285806-363ivs67	218	32	-	-	HYPH
cord-285806-363ivs67	218	33	CoV-2	CoV-2	NNP
cord-285806-363ivs67	218	34	and	and	CC
cord-285806-363ivs67	218	35	COVID-19	COVID-19	NNP
cord-285806-363ivs67	218	36			CD
cord-285806-363ivs67	218	37	IL-6	IL-6	NNP
cord-285806-363ivs67	218	38	pathways	pathway	NNS
cord-285806-363ivs67	218	39	:	:	:
cord-285806-363ivs67	218	40	the	the	DT
cord-285806-363ivs67	218	41	classic	classic	JJ
cord-285806-363ivs67	218	42	(	(	-LRB-
cord-285806-363ivs67	218	43	anti	anti	JJ
cord-285806-363ivs67	218	44	-	-	JJ
cord-285806-363ivs67	218	45	inflammatory	inflammatory	JJ
cord-285806-363ivs67	218	46	)	)	-RRB-
cord-285806-363ivs67	218	47	and	and	CC
cord-285806-363ivs67	218	48	the	the	DT
cord-285806-363ivs67	218	49	trans	trans	NN
cord-285806-363ivs67	218	50	-	-	HYPH
cord-285806-363ivs67	218	51	signaling	signal	VBG
cord-285806-363ivs67	218	52	Possible	possible	JJ
cord-285806-363ivs67	218	53	use	use	NN
cord-285806-363ivs67	218	54	of	of	IN
cord-285806-363ivs67	218	55	SGP130Fc	SGP130Fc	NNS
cord-285806-363ivs67	218	56	to	to	TO
cord-285806-363ivs67	218	57	selectively	selectively	RB
cord-285806-363ivs67	218	58	block	block	VB
cord-285806-363ivs67	218	59	the	the	DT
cord-285806-363ivs67	218	60	IL-6	IL-6	NNP
cord-285806-363ivs67	218	61	trans	trans	NNP
cord-285806-363ivs67	218	62	-	-	JJ
cord-285806-363ivs67	218	63	signaling	signal	VBG
cord-285806-363ivs67	218	64	pathway	pathway	NN
cord-285806-363ivs67	218	65	and	and	CC
cord-285806-363ivs67	218	66	thus	thus	RB
cord-285806-363ivs67	218	67	only	only	RB
cord-285806-363ivs67	218	68	the	the	DT
cord-285806-363ivs67	218	69	pro	pro	JJ
cord-285806-363ivs67	218	70	-	-	JJ
cord-285806-363ivs67	218	71	inflammatory	inflammatory	JJ
cord-285806-363ivs67	218	72	pathway	pathway	NN
cord-285806-363ivs67	218	73	in	in	IN
cord-285806-363ivs67	218	74	SARS	SARS	NNP
cord-285806-363ivs67	218	75	-	-	HYPH
cord-285806-363ivs67	218	76	CoV-2	CoV-2	NNP
cord-285806-363ivs67	218	77	infection	infection	NN
cord-285806-363ivs67	218	78			NFP
cord-285806-363ivs67	219	1	Inhibition	inhibition	NN
cord-285806-363ivs67	219	2	of	of	IN
cord-285806-363ivs67	219	3	the	the	DT
cord-285806-363ivs67	219	4	JAK	JAK	NNP
cord-285806-363ivs67	219	5	/	/	SYM
cord-285806-363ivs67	219	6	STAT	STAT	NNP
cord-285806-363ivs67	219	7	pathway	pathway	NN
cord-285806-363ivs67	219	8	activated	activate	VBN
cord-285806-363ivs67	219	9	by	by	IN
cord-285806-363ivs67	219	10	IL-6	IL-6	NNP
cord-285806-363ivs67	219	11	:	:	:
cord-285806-363ivs67	219	12	Ruxolitinib	Ruxolitinib	NNP
cord-285806-363ivs67	219	13	and	and	CC
cord-285806-363ivs67	219	14	Baricitinib	Baricitinib	NNP