id sid tid token lemma pos cord-282990-qb4wk4yb 1 1 key key NN cord-282990-qb4wk4yb 1 2 : : : cord-282990-qb4wk4yb 1 3 cord-282990-qb4wk4yb cord-282990-qb4wk4yb NNP cord-282990-qb4wk4yb 1 4 authors author NNS cord-282990-qb4wk4yb 1 5 : : : cord-282990-qb4wk4yb 1 6 Chen Chen NNP cord-282990-qb4wk4yb 1 7 , , , cord-282990-qb4wk4yb 1 8 Zhuo Zhuo NNP cord-282990-qb4wk4yb 1 9 ; ; : cord-282990-qb4wk4yb 1 10 Sikorski Sikorski NNP cord-282990-qb4wk4yb 1 11 , , , cord-282990-qb4wk4yb 1 12 Timothy Timothy NNP cord-282990-qb4wk4yb 1 13 W W NNP cord-282990-qb4wk4yb 1 14 title title NN cord-282990-qb4wk4yb 1 15 : : : cord-282990-qb4wk4yb 2 1 Safety safety NN cord-282990-qb4wk4yb 2 2 considerations consideration NNS cord-282990-qb4wk4yb 2 3 in in IN cord-282990-qb4wk4yb 2 4 the the DT cord-282990-qb4wk4yb 2 5 bioanalytical bioanalytical JJ cord-282990-qb4wk4yb 2 6 laboratories laboratory NNS cord-282990-qb4wk4yb 2 7 handling handle VBG cord-282990-qb4wk4yb 2 8 specimens specimen NNS cord-282990-qb4wk4yb 2 9 from from IN cord-282990-qb4wk4yb 2 10 coronavirus coronavirus NN cord-282990-qb4wk4yb 2 11 disease disease NN cord-282990-qb4wk4yb 2 12 2019 2019 CD cord-282990-qb4wk4yb 2 13 patients patient NNS cord-282990-qb4wk4yb 2 14 date date NN cord-282990-qb4wk4yb 2 15 : : : cord-282990-qb4wk4yb 2 16 2020 2020 CD cord-282990-qb4wk4yb 2 17 - - HYPH cord-282990-qb4wk4yb 2 18 08 08 CD cord-282990-qb4wk4yb 2 19 - - SYM cord-282990-qb4wk4yb 2 20 21 21 CD cord-282990-qb4wk4yb 2 21 journal journal NN cord-282990-qb4wk4yb 2 22 : : : cord-282990-qb4wk4yb 3 1 Bioanalysis Bioanalysis NNP cord-282990-qb4wk4yb 3 2 DOI DOI NNP cord-282990-qb4wk4yb 3 3 : : : cord-282990-qb4wk4yb 4 1 10.4155 10.4155 CD cord-282990-qb4wk4yb 5 1 /bio-2020 /bio-2020 LS cord-282990-qb4wk4yb 5 2 - - : cord-282990-qb4wk4yb 5 3 0185 0185 CD cord-282990-qb4wk4yb 6 1 sha sha NNP cord-282990-qb4wk4yb 6 2 : : : cord-282990-qb4wk4yb 6 3 8c1c3403beb0c17a64f05f1aca48e57b38954984 8c1c3403beb0c17a64f05f1aca48e57b38954984 CD cord-282990-qb4wk4yb 6 4 doc_id doc_id CD cord-282990-qb4wk4yb 6 5 : : : cord-282990-qb4wk4yb 7 1 282990 282990 CD cord-282990-qb4wk4yb 7 2 cord_uid cord_uid NNS cord-282990-qb4wk4yb 7 3 : : : cord-282990-qb4wk4yb 8 1 qb4wk4yb qb4wk4yb UH cord-282990-qb4wk4yb 8 2 nan nan NNP cord-282990-qb4wk4yb 8 3 16 16 CD cord-282990-qb4wk4yb 8 4 ( ( -LRB- cord-282990-qb4wk4yb 8 5 100 100 CD cord-282990-qb4wk4yb 8 6 % % NN cord-282990-qb4wk4yb 8 7 ) ) -RRB- cord-282990-qb4wk4yb 8 8 sputum sputum NN cord-282990-qb4wk4yb 8 9 , , . cord-282990-qb4wk4yb 9 1 13 13 CD cord-282990-qb4wk4yb 9 2 of of IN cord-282990-qb4wk4yb 9 3 16 16 CD cord-282990-qb4wk4yb 9 4 ( ( -LRB- cord-282990-qb4wk4yb 9 5 81 81 CD cord-282990-qb4wk4yb 9 6 % % NN cord-282990-qb4wk4yb 9 7 ) ) -RRB- cord-282990-qb4wk4yb 10 1 nasal nasal JJ cord-282990-qb4wk4yb 10 2 swabs swab NNS cord-282990-qb4wk4yb 10 3 , , , cord-282990-qb4wk4yb 10 4 10 10 CD cord-282990-qb4wk4yb 10 5 of of IN cord-282990-qb4wk4yb 10 6 16 16 CD cord-282990-qb4wk4yb 10 7 ( ( -LRB- cord-282990-qb4wk4yb 10 8 63 63 CD cord-282990-qb4wk4yb 10 9 % % NN cord-282990-qb4wk4yb 10 10 ) ) -RRB- cord-282990-qb4wk4yb 10 11 throat throat NN cord-282990-qb4wk4yb 10 12 swabs swab NNS cord-282990-qb4wk4yb 10 13 , , , cord-282990-qb4wk4yb 10 14 11 11 CD cord-282990-qb4wk4yb 10 15 of of IN cord-282990-qb4wk4yb 10 16 16 16 CD cord-282990-qb4wk4yb 10 17 ( ( -LRB- cord-282990-qb4wk4yb 10 18 69 69 CD cord-282990-qb4wk4yb 10 19 % % NN cord-282990-qb4wk4yb 10 20 ) ) -RRB- cord-282990-qb4wk4yb 10 21 feces fece NNS cord-282990-qb4wk4yb 10 22 , , , cord-282990-qb4wk4yb 10 23 one one CD cord-282990-qb4wk4yb 10 24 of of IN cord-282990-qb4wk4yb 10 25 16 16 CD cord-282990-qb4wk4yb 10 26 ( ( -LRB- cord-282990-qb4wk4yb 10 27 6 6 CD cord-282990-qb4wk4yb 10 28 % % NN cord-282990-qb4wk4yb 10 29 ) ) -RRB- cord-282990-qb4wk4yb 10 30 blood blood NN cord-282990-qb4wk4yb 10 31 and and CC cord-282990-qb4wk4yb 10 32 one one CD cord-282990-qb4wk4yb 10 33 of of IN cord-282990-qb4wk4yb 10 34 16 16 CD cord-282990-qb4wk4yb 10 35 ( ( -LRB- cord-282990-qb4wk4yb 10 36 6 6 CD cord-282990-qb4wk4yb 10 37 % % NN cord-282990-qb4wk4yb 10 38 ) ) -RRB- cord-282990-qb4wk4yb 10 39 urine urine NN cord-282990-qb4wk4yb 10 40 [ [ -LRB- cord-282990-qb4wk4yb 10 41 6 6 CD cord-282990-qb4wk4yb 10 42 ] ] -RRB- cord-282990-qb4wk4yb 10 43 . . . cord-282990-qb4wk4yb 11 1 Since since IN cord-282990-qb4wk4yb 11 2 blood blood NN cord-282990-qb4wk4yb 11 3 specimen specimen NN cord-282990-qb4wk4yb 11 4 is be VBZ cord-282990-qb4wk4yb 11 5 one one CD cord-282990-qb4wk4yb 11 6 of of IN cord-282990-qb4wk4yb 11 7 the the DT cord-282990-qb4wk4yb 11 8 most most RBS cord-282990-qb4wk4yb 11 9 commonly commonly RB cord-282990-qb4wk4yb 11 10 analyzed analyze VBN cord-282990-qb4wk4yb 11 11 sample sample NN cord-282990-qb4wk4yb 11 12 types type NNS cord-282990-qb4wk4yb 11 13 , , , cord-282990-qb4wk4yb 11 14 viral viral JJ cord-282990-qb4wk4yb 11 15 load load NN cord-282990-qb4wk4yb 11 16 of of IN cord-282990-qb4wk4yb 11 17 SARS SARS NNP cord-282990-qb4wk4yb 11 18 - - HYPH cord-282990-qb4wk4yb 11 19 CoV-2 CoV-2 NNP cord-282990-qb4wk4yb 11 20 in in IN cord-282990-qb4wk4yb 11 21 blood blood NN cord-282990-qb4wk4yb 11 22 is be VBZ cord-282990-qb4wk4yb 11 23 a a DT cord-282990-qb4wk4yb 11 24 key key JJ cord-282990-qb4wk4yb 11 25 issue issue NN cord-282990-qb4wk4yb 11 26 for for IN cord-282990-qb4wk4yb 11 27 laboratory laboratory NN cord-282990-qb4wk4yb 11 28 biosafety biosafety NN cord-282990-qb4wk4yb 11 29 . . . cord-282990-qb4wk4yb 12 1 Besides besides IN cord-282990-qb4wk4yb 12 2 the the DT cord-282990-qb4wk4yb 12 3 above above JJ cord-282990-qb4wk4yb 12 4 three three CD cord-282990-qb4wk4yb 12 5 studies study NNS cord-282990-qb4wk4yb 12 6 , , , cord-282990-qb4wk4yb 12 7 other other JJ cord-282990-qb4wk4yb 12 8 recently recently RB cord-282990-qb4wk4yb 12 9 published publish VBN cord-282990-qb4wk4yb 12 10 papers paper NNS cord-282990-qb4wk4yb 12 11 also also RB cord-282990-qb4wk4yb 12 12 demonstrated demonstrate VBD cord-282990-qb4wk4yb 12 13 that that IN cord-282990-qb4wk4yb 12 14 the the DT cord-282990-qb4wk4yb 12 15 detection detection NN cord-282990-qb4wk4yb 12 16 rates rate NNS cord-282990-qb4wk4yb 12 17 of of IN cord-282990-qb4wk4yb 12 18 SARS SARS NNP cord-282990-qb4wk4yb 12 19 - - HYPH cord-282990-qb4wk4yb 12 20 CoV-2 CoV-2 NNP cord-282990-qb4wk4yb 12 21 RNA RNA NNP cord-282990-qb4wk4yb 12 22 in in IN cord-282990-qb4wk4yb 12 23 blood blood NN cord-282990-qb4wk4yb 12 24 from from IN cord-282990-qb4wk4yb 12 25 COVID-19 covid-19 JJ cord-282990-qb4wk4yb 12 26 patients patient NNS cord-282990-qb4wk4yb 12 27 were be VBD cord-282990-qb4wk4yb 12 28 generally generally RB cord-282990-qb4wk4yb 12 29 low low JJ cord-282990-qb4wk4yb 12 30 as as IN cord-282990-qb4wk4yb 12 31 : : : cord-282990-qb4wk4yb 12 32 five five CD cord-282990-qb4wk4yb 12 33 of of IN cord-282990-qb4wk4yb 12 34 48 48 CD cord-282990-qb4wk4yb 12 35 ( ( -LRB- cord-282990-qb4wk4yb 12 36 10 10 CD cord-282990-qb4wk4yb 12 37 % % NN cord-282990-qb4wk4yb 12 38 ) ) -RRB- cord-282990-qb4wk4yb 12 39 [ [ -LRB- cord-282990-qb4wk4yb 12 40 1 1 CD cord-282990-qb4wk4yb 12 41 ] ] -RRB- cord-282990-qb4wk4yb 12 42 , , , cord-282990-qb4wk4yb 12 43 two two CD cord-282990-qb4wk4yb 12 44 of of IN cord-282990-qb4wk4yb 12 45 9 9 CD cord-282990-qb4wk4yb 12 46 ( ( -LRB- cord-282990-qb4wk4yb 12 47 22 22 CD cord-282990-qb4wk4yb 12 48 % % NN cord-282990-qb4wk4yb 12 49 ) ) -RRB- cord-282990-qb4wk4yb 13 1 [ [ -LRB- cord-282990-qb4wk4yb 13 2 2 2 CD cord-282990-qb4wk4yb 13 3 ] ] -RRB- cord-282990-qb4wk4yb 13 4 and and CC cord-282990-qb4wk4yb 13 5 six six CD cord-282990-qb4wk4yb 13 6 of of IN cord-282990-qb4wk4yb 13 7 41 41 CD cord-282990-qb4wk4yb 13 8 ( ( -LRB- cord-282990-qb4wk4yb 13 9 15 15 CD cord-282990-qb4wk4yb 13 10 % % NN cord-282990-qb4wk4yb 13 11 ) ) -RRB- cord-282990-qb4wk4yb 13 12 [ [ -LRB- cord-282990-qb4wk4yb 13 13 3 3 CD cord-282990-qb4wk4yb 13 14 ] ] -RRB- cord-282990-qb4wk4yb 13 15 . . . cord-282990-qb4wk4yb 14 1 These these DT cord-282990-qb4wk4yb 14 2 results result NNS cord-282990-qb4wk4yb 14 3 were be VBD cord-282990-qb4wk4yb 14 4 consistent consistent JJ cord-282990-qb4wk4yb 14 5 with with IN cord-282990-qb4wk4yb 14 6 the the DT cord-282990-qb4wk4yb 14 7 previous previous JJ cord-282990-qb4wk4yb 14 8 studies study NNS cord-282990-qb4wk4yb 14 9 on on IN cord-282990-qb4wk4yb 14 10 other other JJ cord-282990-qb4wk4yb 14 11 coronaviruses coronaviruse NNS cord-282990-qb4wk4yb 14 12 , , , cord-282990-qb4wk4yb 14 13 which which WDT cord-282990-qb4wk4yb 14 14 showed show VBD cord-282990-qb4wk4yb 14 15 a a DT cord-282990-qb4wk4yb 14 16 much much RB cord-282990-qb4wk4yb 14 17 lower low JJR cord-282990-qb4wk4yb 14 18 viral viral JJ cord-282990-qb4wk4yb 14 19 load load NN cord-282990-qb4wk4yb 14 20 in in IN cord-282990-qb4wk4yb 14 21 the the DT cord-282990-qb4wk4yb 14 22 nonrespiratory nonrespiratory NN cord-282990-qb4wk4yb 14 23 specimens specimen NNS cord-282990-qb4wk4yb 14 24 including include VBG cord-282990-qb4wk4yb 14 25 blood blood NN cord-282990-qb4wk4yb 14 26 and and CC cord-282990-qb4wk4yb 14 27 urine urine NN cord-282990-qb4wk4yb 14 28 [ [ -LRB- cord-282990-qb4wk4yb 14 29 4 4 CD cord-282990-qb4wk4yb 14 30 , , , cord-282990-qb4wk4yb 14 31 8 8 CD cord-282990-qb4wk4yb 14 32 ] ] -RRB- cord-282990-qb4wk4yb 14 33 . . . cord-282990-qb4wk4yb 15 1 Direct direct JJ cord-282990-qb4wk4yb 15 2 contact contact NN cord-282990-qb4wk4yb 15 3 and and CC cord-282990-qb4wk4yb 15 4 airborne airborne JJ cord-282990-qb4wk4yb 15 5 transmission transmission NN cord-282990-qb4wk4yb 15 6 are be VBP cord-282990-qb4wk4yb 15 7 considered consider VBN cord-282990-qb4wk4yb 15 8 the the DT cord-282990-qb4wk4yb 15 9 major major JJ cord-282990-qb4wk4yb 15 10 routes route NNS cord-282990-qb4wk4yb 15 11 of of IN cord-282990-qb4wk4yb 15 12 spread spread NN cord-282990-qb4wk4yb 15 13 of of IN cord-282990-qb4wk4yb 15 14 coronaviruses coronaviruse NNS cord-282990-qb4wk4yb 15 15 . . . cord-282990-qb4wk4yb 16 1 Moreover moreover RB cord-282990-qb4wk4yb 16 2 , , , cord-282990-qb4wk4yb 16 3 detection detection NN cord-282990-qb4wk4yb 16 4 of of IN cord-282990-qb4wk4yb 16 5 viral viral JJ cord-282990-qb4wk4yb 16 6 RNA RNA NNP cord-282990-qb4wk4yb 16 7 in in IN cord-282990-qb4wk4yb 16 8 the the DT cord-282990-qb4wk4yb 16 9 matrix matrix NN cord-282990-qb4wk4yb 16 10 does do VBZ cord-282990-qb4wk4yb 16 11 not not RB cord-282990-qb4wk4yb 16 12 mean mean VB cord-282990-qb4wk4yb 16 13 that that IN cord-282990-qb4wk4yb 16 14 the the DT cord-282990-qb4wk4yb 16 15 RNA RNA NNP cord-282990-qb4wk4yb 16 16 retains retain VBZ cord-282990-qb4wk4yb 16 17 its -PRON- PRP$ cord-282990-qb4wk4yb 16 18 original original JJ cord-282990-qb4wk4yb 16 19 length length NN cord-282990-qb4wk4yb 16 20 or or CC cord-282990-qb4wk4yb 16 21 is be VBZ cord-282990-qb4wk4yb 16 22 part part NN cord-282990-qb4wk4yb 16 23 of of IN cord-282990-qb4wk4yb 16 24 a a DT cord-282990-qb4wk4yb 16 25 live live JJ cord-282990-qb4wk4yb 16 26 infectious infectious JJ cord-282990-qb4wk4yb 16 27 virus virus NN cord-282990-qb4wk4yb 16 28 . . . cord-282990-qb4wk4yb 17 1 So so RB cord-282990-qb4wk4yb 17 2 far far RB cord-282990-qb4wk4yb 17 3 , , , cord-282990-qb4wk4yb 17 4 no no DT cord-282990-qb4wk4yb 17 5 research research NN cord-282990-qb4wk4yb 17 6 has have VBZ cord-282990-qb4wk4yb 17 7 observed observe VBN cord-282990-qb4wk4yb 17 8 infective infective JJ cord-282990-qb4wk4yb 17 9 SARS SARS NNP cord-282990-qb4wk4yb 17 10 - - HYPH cord-282990-qb4wk4yb 17 11 CoV-2 CoV-2 NNP cord-282990-qb4wk4yb 17 12 particles particle NNS cord-282990-qb4wk4yb 17 13 in in IN cord-282990-qb4wk4yb 17 14 blood blood NN cord-282990-qb4wk4yb 17 15 [ [ -LRB- cord-282990-qb4wk4yb 17 16 9 9 CD cord-282990-qb4wk4yb 17 17 ] ] -RRB- cord-282990-qb4wk4yb 17 18 . . . cord-282990-qb4wk4yb 18 1 Finally finally RB cord-282990-qb4wk4yb 18 2 , , , cord-282990-qb4wk4yb 18 3 a a DT cord-282990-qb4wk4yb 18 4 recent recent JJ cord-282990-qb4wk4yb 18 5 study study NN cord-282990-qb4wk4yb 18 6 compared compare VBD cord-282990-qb4wk4yb 18 7 the the DT cord-282990-qb4wk4yb 18 8 detection detection NN cord-282990-qb4wk4yb 18 9 of of IN cord-282990-qb4wk4yb 18 10 SARS SARS NNP cord-282990-qb4wk4yb 18 11 - - HYPH cord-282990-qb4wk4yb 18 12 CoV-2 CoV-2 NNP cord-282990-qb4wk4yb 18 13 RNA RNA NNP cord-282990-qb4wk4yb 18 14 in in IN cord-282990-qb4wk4yb 18 15 serum serum NN cord-282990-qb4wk4yb 18 16 of of IN cord-282990-qb4wk4yb 18 17 48 48 CD cord-282990-qb4wk4yb 18 18 patients patient NNS cord-282990-qb4wk4yb 18 19 with with IN cord-282990-qb4wk4yb 18 20 varying vary VBG cord-282990-qb4wk4yb 18 21 severity severity NN cord-282990-qb4wk4yb 18 22 [ [ -LRB- cord-282990-qb4wk4yb 18 23 1 1 CD cord-282990-qb4wk4yb 18 24 ] ] -RRB- cord-282990-qb4wk4yb 18 25 . . . cord-282990-qb4wk4yb 19 1 Although although IN cord-282990-qb4wk4yb 19 2 all all DT cord-282990-qb4wk4yb 19 3 throat throat NN cord-282990-qb4wk4yb 19 4 swab swab NN cord-282990-qb4wk4yb 19 5 specimens specimen NNS cord-282990-qb4wk4yb 19 6 from from IN cord-282990-qb4wk4yb 19 7 these these DT cord-282990-qb4wk4yb 19 8 patients patient NNS cord-282990-qb4wk4yb 19 9 were be VBD cord-282990-qb4wk4yb 19 10 tested test VBN cord-282990-qb4wk4yb 19 11 positive positive JJ cord-282990-qb4wk4yb 19 12 , , , cord-282990-qb4wk4yb 19 13 only only RB cord-282990-qb4wk4yb 19 14 five five CD cord-282990-qb4wk4yb 19 15 showed show VBD cord-282990-qb4wk4yb 19 16 positive positive JJ cord-282990-qb4wk4yb 19 17 detection detection NN cord-282990-qb4wk4yb 19 18 in in IN cord-282990-qb4wk4yb 19 19 serum serum NN cord-282990-qb4wk4yb 19 20 and and CC cord-282990-qb4wk4yb 19 21 all all DT cord-282990-qb4wk4yb 19 22 came come VBD cord-282990-qb4wk4yb 19 23 from from IN cord-282990-qb4wk4yb 19 24 critically critically RB cord-282990-qb4wk4yb 19 25 ill ill JJ cord-282990-qb4wk4yb 19 26 patients patient NNS cord-282990-qb4wk4yb 19 27 ( ( -LRB- cord-282990-qb4wk4yb 19 28 two two CD cord-282990-qb4wk4yb 19 29 of of IN cord-282990-qb4wk4yb 19 30 whom whom WP cord-282990-qb4wk4yb 19 31 died die VBD cord-282990-qb4wk4yb 19 32 of of IN cord-282990-qb4wk4yb 19 33 the the DT cord-282990-qb4wk4yb 19 34 disease disease NN cord-282990-qb4wk4yb 19 35 ) ) -RRB- cord-282990-qb4wk4yb 19 36 . . . cord-282990-qb4wk4yb 20 1 No no DT cord-282990-qb4wk4yb 20 2 viral viral JJ cord-282990-qb4wk4yb 20 3 RNA RNA NNP cord-282990-qb4wk4yb 20 4 was be VBD cord-282990-qb4wk4yb 20 5 detected detect VBN cord-282990-qb4wk4yb 20 6 from from IN cord-282990-qb4wk4yb 20 7 serum serum NN cord-282990-qb4wk4yb 20 8 in in IN cord-282990-qb4wk4yb 20 9 the the DT cord-282990-qb4wk4yb 20 10 mild mild JJ cord-282990-qb4wk4yb 20 11 or or CC cord-282990-qb4wk4yb 20 12 severe severe JJ cord-282990-qb4wk4yb 20 13 cohort cohort NN cord-282990-qb4wk4yb 20 14 , , , cord-282990-qb4wk4yb 20 15 which which WDT cord-282990-qb4wk4yb 20 16 may may MD cord-282990-qb4wk4yb 20 17 represent represent VB cord-282990-qb4wk4yb 20 18 the the DT cord-282990-qb4wk4yb 20 19 majority majority NN cord-282990-qb4wk4yb 20 20 of of IN cord-282990-qb4wk4yb 20 21 COVID-19 covid-19 JJ cord-282990-qb4wk4yb 20 22 patient patient NN cord-282990-qb4wk4yb 20 23 samples sample NNS cord-282990-qb4wk4yb 20 24 . . . cord-282990-qb4wk4yb 21 1 Therefore therefore RB cord-282990-qb4wk4yb 21 2 , , , cord-282990-qb4wk4yb 21 3 according accord VBG cord-282990-qb4wk4yb 21 4 to to IN cord-282990-qb4wk4yb 21 5 current current JJ cord-282990-qb4wk4yb 21 6 knowledge knowledge NN cord-282990-qb4wk4yb 21 7 , , , cord-282990-qb4wk4yb 21 8 the the DT cord-282990-qb4wk4yb 21 9 risk risk NN cord-282990-qb4wk4yb 21 10 of of IN cord-282990-qb4wk4yb 21 11 processing process VBG cord-282990-qb4wk4yb 21 12 blood blood NN cord-282990-qb4wk4yb 21 13 specimens specimen NNS cord-282990-qb4wk4yb 21 14 from from IN cord-282990-qb4wk4yb 21 15 COVID-19 covid-19 JJ cord-282990-qb4wk4yb 21 16 patients patient NNS cord-282990-qb4wk4yb 21 17 is be VBZ cord-282990-qb4wk4yb 21 18 not not RB cord-282990-qb4wk4yb 21 19 considered consider VBN cord-282990-qb4wk4yb 21 20 to to TO cord-282990-qb4wk4yb 21 21 be be VB cord-282990-qb4wk4yb 21 22 high high JJ cord-282990-qb4wk4yb 21 23 . . . cord-282990-qb4wk4yb 22 1 Nevertheless nevertheless RB cord-282990-qb4wk4yb 22 2 , , , cord-282990-qb4wk4yb 22 3 there there EX cord-282990-qb4wk4yb 22 4 is be VBZ cord-282990-qb4wk4yb 22 5 still still RB cord-282990-qb4wk4yb 22 6 much much JJ cord-282990-qb4wk4yb 22 7 work work NN cord-282990-qb4wk4yb 22 8 to to TO cord-282990-qb4wk4yb 22 9 be be VB cord-282990-qb4wk4yb 22 10 done do VBN cord-282990-qb4wk4yb 22 11 in in IN cord-282990-qb4wk4yb 22 12 understanding understand VBG cord-282990-qb4wk4yb 22 13 the the DT cord-282990-qb4wk4yb 22 14 infectivity infectivity NN cord-282990-qb4wk4yb 22 15 of of IN cord-282990-qb4wk4yb 22 16 blood blood NN cord-282990-qb4wk4yb 22 17 derived derive VBN cord-282990-qb4wk4yb 22 18 samples sample NNS cord-282990-qb4wk4yb 22 19 from from IN cord-282990-qb4wk4yb 22 20 COVID-19 covid-19 JJ cord-282990-qb4wk4yb 22 21 patients patient NNS cord-282990-qb4wk4yb 22 22 , , , cord-282990-qb4wk4yb 22 23 and and CC cord-282990-qb4wk4yb 22 24 at at IN cord-282990-qb4wk4yb 22 25 this this DT cord-282990-qb4wk4yb 22 26 time time NN cord-282990-qb4wk4yb 22 27 any any DT cord-282990-qb4wk4yb 22 28 risk risk NN cord-282990-qb4wk4yb 22 29 of of IN cord-282990-qb4wk4yb 22 30 exposure exposure NN cord-282990-qb4wk4yb 22 31 to to IN cord-282990-qb4wk4yb 22 32 laboratorians laboratorian NNS cord-282990-qb4wk4yb 22 33 should should MD cord-282990-qb4wk4yb 22 34 be be VB cord-282990-qb4wk4yb 22 35 mitigated mitigate VBN cord-282990-qb4wk4yb 22 36 , , , cord-282990-qb4wk4yb 22 37 as as IN cord-282990-qb4wk4yb 22 38 described describe VBN cord-282990-qb4wk4yb 22 39 below below RB cord-282990-qb4wk4yb 22 40 . . . cord-282990-qb4wk4yb 23 1 Despite despite IN cord-282990-qb4wk4yb 23 2 the the DT cord-282990-qb4wk4yb 23 3 relatively relatively RB cord-282990-qb4wk4yb 23 4 low low JJ cord-282990-qb4wk4yb 23 5 SARS SARS NNP cord-282990-qb4wk4yb 23 6 - - HYPH cord-282990-qb4wk4yb 23 7 CoV-2 CoV-2 NNP cord-282990-qb4wk4yb 23 8 viral viral JJ cord-282990-qb4wk4yb 23 9 load load NN cord-282990-qb4wk4yb 23 10 detected detect VBN cord-282990-qb4wk4yb 23 11 in in IN cord-282990-qb4wk4yb 23 12 the the DT cord-282990-qb4wk4yb 23 13 blood blood NN cord-282990-qb4wk4yb 23 14 and and CC cord-282990-qb4wk4yb 23 15 urine urine NN cord-282990-qb4wk4yb 23 16 of of IN cord-282990-qb4wk4yb 23 17 COVID-19 covid-19 JJ cord-282990-qb4wk4yb 23 18 patients patient NNS cord-282990-qb4wk4yb 23 19 , , , cord-282990-qb4wk4yb 23 20 scientists scientist NNS cord-282990-qb4wk4yb 23 21 have have VBP cord-282990-qb4wk4yb 23 22 yet yet RB cord-282990-qb4wk4yb 23 23 to to TO cord-282990-qb4wk4yb 23 24 draw draw VB cord-282990-qb4wk4yb 23 25 conclusions conclusion NNS cord-282990-qb4wk4yb 23 26 about about IN cord-282990-qb4wk4yb 23 27 the the DT cord-282990-qb4wk4yb 23 28 infectivity infectivity NN cord-282990-qb4wk4yb 23 29 of of IN cord-282990-qb4wk4yb 23 30 these these DT cord-282990-qb4wk4yb 23 31 specimens specimen NNS cord-282990-qb4wk4yb 23 32 . . . cord-282990-qb4wk4yb 24 1 The the DT cord-282990-qb4wk4yb 24 2 Centers Centers NNPS cord-282990-qb4wk4yb 24 3 for for IN cord-282990-qb4wk4yb 24 4 Disease Disease NNP cord-282990-qb4wk4yb 24 5 Control Control NNP cord-282990-qb4wk4yb 24 6 and and CC cord-282990-qb4wk4yb 24 7 Prevention Prevention NNP cord-282990-qb4wk4yb 24 8 ( ( -LRB- cord-282990-qb4wk4yb 24 9 CDC CDC NNP cord-282990-qb4wk4yb 24 10 ) ) -RRB- cord-282990-qb4wk4yb 24 11 has have VBZ cord-282990-qb4wk4yb 24 12 issued issue VBN cord-282990-qb4wk4yb 24 13 the the DT cord-282990-qb4wk4yb 24 14 interim interim JJ cord-282990-qb4wk4yb 24 15 laboratory laboratory NN cord-282990-qb4wk4yb 24 16 biosafety biosafety NN cord-282990-qb4wk4yb 24 17 guidelines guideline NNS cord-282990-qb4wk4yb 24 18 for for IN cord-282990-qb4wk4yb 24 19 handling handle VBG cord-282990-qb4wk4yb 24 20 COVID-19 covid-19 JJ cord-282990-qb4wk4yb 24 21 specimens specimen NNS cord-282990-qb4wk4yb 24 22 , , , cord-282990-qb4wk4yb 24 23 which which WDT cord-282990-qb4wk4yb 24 24 recommends recommend VBZ cord-282990-qb4wk4yb 24 25 virus virus NN cord-282990-qb4wk4yb 24 26 inactivation inactivation NN cord-282990-qb4wk4yb 24 27 prior prior RB cord-282990-qb4wk4yb 24 28 to to IN cord-282990-qb4wk4yb 24 29 sample sample NN cord-282990-qb4wk4yb 24 30 processing processing NN cord-282990-qb4wk4yb 24 31 to to TO cord-282990-qb4wk4yb 24 32 reduce reduce VB cord-282990-qb4wk4yb 24 33 the the DT cord-282990-qb4wk4yb 24 34 risk risk NN cord-282990-qb4wk4yb 24 35 of of IN cord-282990-qb4wk4yb 24 36 infection infection NN cord-282990-qb4wk4yb 24 37 [ [ -LRB- cord-282990-qb4wk4yb 24 38 10 10 CD cord-282990-qb4wk4yb 24 39 ] ] -RRB- cord-282990-qb4wk4yb 24 40 . . . cord-282990-qb4wk4yb 25 1 Coronaviruses coronaviruse NNS cord-282990-qb4wk4yb 25 2 are be VBP cord-282990-qb4wk4yb 25 3 enveloped envelop VBN cord-282990-qb4wk4yb 25 4 ssRNA ssRNA VBG cord-282990-qb4wk4yb 25 5 viruses virus NNS cord-282990-qb4wk4yb 25 6 that that WDT cord-282990-qb4wk4yb 25 7 are be VBP cord-282990-qb4wk4yb 25 8 usually usually RB cord-282990-qb4wk4yb 25 9 thermolabile thermolabile JJ cord-282990-qb4wk4yb 25 10 and and CC cord-282990-qb4wk4yb 25 11 unstable unstable JJ cord-282990-qb4wk4yb 25 12 under under IN cord-282990-qb4wk4yb 25 13 acidic acidic JJ cord-282990-qb4wk4yb 25 14 or or CC cord-282990-qb4wk4yb 25 15 alkaline alkaline JJ cord-282990-qb4wk4yb 25 16 conditions condition NNS cord-282990-qb4wk4yb 25 17 . . . cord-282990-qb4wk4yb 26 1 However however RB cord-282990-qb4wk4yb 26 2 , , , cord-282990-qb4wk4yb 26 3 they -PRON- PRP cord-282990-qb4wk4yb 26 4 are be VBP cord-282990-qb4wk4yb 26 5 more more RBR cord-282990-qb4wk4yb 26 6 stable stable JJ cord-282990-qb4wk4yb 26 7 at at IN cord-282990-qb4wk4yb 26 8 4 4 CD cord-282990-qb4wk4yb 26 9 • • NN cord-282990-qb4wk4yb 26 10 C c NN cord-282990-qb4wk4yb 26 11 and and CC cord-282990-qb4wk4yb 26 12 can can MD cord-282990-qb4wk4yb 26 13 remain remain VB cord-282990-qb4wk4yb 26 14 infectious infectious JJ cord-282990-qb4wk4yb 26 15 after after IN cord-282990-qb4wk4yb 26 16 25 25 CD cord-282990-qb4wk4yb 26 17 cycles cycle NNS cord-282990-qb4wk4yb 26 18 of of IN cord-282990-qb4wk4yb 26 19 freezing freeze VBG cord-282990-qb4wk4yb 26 20 and and CC cord-282990-qb4wk4yb 26 21 thawing thaw VBG cord-282990-qb4wk4yb 26 22 [ [ -LRB- cord-282990-qb4wk4yb 26 23 4 4 CD cord-282990-qb4wk4yb 26 24 ] ] -RRB- cord-282990-qb4wk4yb 26 25 . . . cord-282990-qb4wk4yb 27 1 At at IN cord-282990-qb4wk4yb 27 2 present present JJ cord-282990-qb4wk4yb 27 3 , , , cord-282990-qb4wk4yb 27 4 most most RBS cord-282990-qb4wk4yb 27 5 reported report VBD cord-282990-qb4wk4yb 27 6 protocols protocol NNS cord-282990-qb4wk4yb 27 7 for for IN cord-282990-qb4wk4yb 27 8 inactivating inactivate VBG cord-282990-qb4wk4yb 27 9 SARS SARS NNP cord-282990-qb4wk4yb 27 10 - - HYPH cord-282990-qb4wk4yb 27 11 CoV-2 CoV-2 NNP cord-282990-qb4wk4yb 27 12 are be VBP cord-282990-qb4wk4yb 27 13 based base VBN cord-282990-qb4wk4yb 27 14 on on IN cord-282990-qb4wk4yb 27 15 the the DT cord-282990-qb4wk4yb 27 16 inactivation inactivation NN cord-282990-qb4wk4yb 27 17 methods method NNS cord-282990-qb4wk4yb 27 18 for for IN cord-282990-qb4wk4yb 27 19 SARS SARS NNP cord-282990-qb4wk4yb 27 20 - - HYPH cord-282990-qb4wk4yb 27 21 CoV CoV NNP cord-282990-qb4wk4yb 27 22 and and CC cord-282990-qb4wk4yb 27 23 MERS MERS NNP cord-282990-qb4wk4yb 27 24 - - HYPH cord-282990-qb4wk4yb 27 25 CoV. CoV. NNP cord-282990-qb4wk4yb 27 26 They -PRON- PRP cord-282990-qb4wk4yb 27 27 are be VBP cord-282990-qb4wk4yb 27 28 generally generally RB cord-282990-qb4wk4yb 27 29 classified classify VBN cord-282990-qb4wk4yb 27 30 into into IN cord-282990-qb4wk4yb 27 31 two two CD cord-282990-qb4wk4yb 27 32 categories category NNS cord-282990-qb4wk4yb 27 33 : : : cord-282990-qb4wk4yb 27 34 heating heating NN cord-282990-qb4wk4yb 27 35 protocols protocol NNS cord-282990-qb4wk4yb 27 36 and and CC cord-282990-qb4wk4yb 27 37 chemical chemical NN cord-282990-qb4wk4yb 27 38 protocols protocol NNS cord-282990-qb4wk4yb 27 39 . . . cord-282990-qb4wk4yb 28 1 Wang Wang NNP cord-282990-qb4wk4yb 28 2 et et NNP cord-282990-qb4wk4yb 28 3 al al NNP cord-282990-qb4wk4yb 28 4 . . . cord-282990-qb4wk4yb 29 1 compared compare VBN cord-282990-qb4wk4yb 29 2 the the DT cord-282990-qb4wk4yb 29 3 infectious infectious JJ cord-282990-qb4wk4yb 29 4 titer titer NN cord-282990-qb4wk4yb 29 5 of of IN cord-282990-qb4wk4yb 29 6 SARS SARS NNP cord-282990-qb4wk4yb 29 7 - - HYPH cord-282990-qb4wk4yb 29 8 CoV-2 CoV-2 NNP cord-282990-qb4wk4yb 29 9 after after IN cord-282990-qb4wk4yb 29 10 heating heat VBG cord-282990-qb4wk4yb 29 11 the the DT cord-282990-qb4wk4yb 29 12 samples sample NNS cord-282990-qb4wk4yb 29 13 at at IN cord-282990-qb4wk4yb 29 14 different different JJ cord-282990-qb4wk4yb 29 15 temperatures temperature NNS cord-282990-qb4wk4yb 29 16 for for IN cord-282990-qb4wk4yb 29 17 different different JJ cord-282990-qb4wk4yb 29 18 periods period NNS cord-282990-qb4wk4yb 29 19 [ [ -LRB- cord-282990-qb4wk4yb 29 20 11 11 CD cord-282990-qb4wk4yb 29 21 ] ] -RRB- cord-282990-qb4wk4yb 29 22 . . . cord-282990-qb4wk4yb 30 1 They -PRON- PRP cord-282990-qb4wk4yb 30 2 found find VBD cord-282990-qb4wk4yb 30 3 that that IN cord-282990-qb4wk4yb 30 4 heating heat VBG cord-282990-qb4wk4yb 30 5 the the DT cord-282990-qb4wk4yb 30 6 specimens specimen NNS cord-282990-qb4wk4yb 30 7 ( ( -LRB- cord-282990-qb4wk4yb 30 8 human human JJ cord-282990-qb4wk4yb 30 9 serum serum NN cord-282990-qb4wk4yb 30 10 or or CC cord-282990-qb4wk4yb 30 11 sputum sputum NN cord-282990-qb4wk4yb 30 12 ) ) -RRB- cord-282990-qb4wk4yb 30 13 at at IN cord-282990-qb4wk4yb 30 14 56 56 CD cord-282990-qb4wk4yb 31 1 • • NNP cord-282990-qb4wk4yb 31 2 C C NNP cord-282990-qb4wk4yb 31 3 for for IN cord-282990-qb4wk4yb 31 4 30 30 CD cord-282990-qb4wk4yb 31 5 min min NN cord-282990-qb4wk4yb 31 6 efficiently efficiently RB cord-282990-qb4wk4yb 31 7 inactivated inactivate VBD cord-282990-qb4wk4yb 31 8 any any DT cord-282990-qb4wk4yb 31 9 infectious infectious JJ cord-282990-qb4wk4yb 31 10 SARS SARS NNP cord-282990-qb4wk4yb 31 11 - - HYPH cord-282990-qb4wk4yb 31 12 CoV-2 CoV-2 NNP cord-282990-qb4wk4yb 31 13 while while IN cord-282990-qb4wk4yb 31 14 preserving preserve VBG cord-282990-qb4wk4yb 31 15 viral viral JJ cord-282990-qb4wk4yb 31 16 RNA RNA NNP cord-282990-qb4wk4yb 31 17 . . . cord-282990-qb4wk4yb 32 1 Unlike unlike IN cord-282990-qb4wk4yb 32 2 some some DT cord-282990-qb4wk4yb 32 3 other other JJ cord-282990-qb4wk4yb 32 4 thermolabile thermolabile NN cord-282990-qb4wk4yb 32 5 coronaviruses coronaviruse NNS cord-282990-qb4wk4yb 32 6 , , , cord-282990-qb4wk4yb 32 7 SARS SARS NNP cord-282990-qb4wk4yb 32 8 - - HYPH cord-282990-qb4wk4yb 32 9 CoV-2 CoV-2 NNP cord-282990-qb4wk4yb 32 10 was be VBD cord-282990-qb4wk4yb 32 11 observed observe VBN cord-282990-qb4wk4yb 32 12 to to TO cord-282990-qb4wk4yb 32 13 be be VB cord-282990-qb4wk4yb 32 14 stable stable JJ cord-282990-qb4wk4yb 32 15 at at IN cord-282990-qb4wk4yb 32 16 37 37 CD cord-282990-qb4wk4yb 32 17 • • NN cord-282990-qb4wk4yb 32 18 C c NN cord-282990-qb4wk4yb 32 19 for for IN cord-282990-qb4wk4yb 32 20 at at RB cord-282990-qb4wk4yb 32 21 least least RBS cord-282990-qb4wk4yb 32 22 24 24 CD cord-282990-qb4wk4yb 32 23 h. h. NN cord-282990-qb4wk4yb 33 1 This this DT cord-282990-qb4wk4yb 33 2 finding finding NN cord-282990-qb4wk4yb 33 3 may may MD cord-282990-qb4wk4yb 33 4 partially partially RB cord-282990-qb4wk4yb 33 5 explain explain VB cord-282990-qb4wk4yb 33 6 why why WRB cord-282990-qb4wk4yb 33 7 COVID-19 covid-19 JJ cord-282990-qb4wk4yb 33 8 outbreaks outbreak NNS cord-282990-qb4wk4yb 33 9 can can MD cord-282990-qb4wk4yb 33 10 occur occur VB cord-282990-qb4wk4yb 33 11 in in IN cord-282990-qb4wk4yb 33 12 some some DT cord-282990-qb4wk4yb 33 13 tropical tropical JJ cord-282990-qb4wk4yb 33 14 countries country NNS cord-282990-qb4wk4yb 33 15 . . . cord-282990-qb4wk4yb 34 1 Another another DT cord-282990-qb4wk4yb 34 2 study study NN cord-282990-qb4wk4yb 34 3 also also RB cord-282990-qb4wk4yb 34 4 showed show VBD cord-282990-qb4wk4yb 34 5 that that IN cord-282990-qb4wk4yb 34 6 heating heating NN cord-282990-qb4wk4yb 34 7 at at IN cord-282990-qb4wk4yb 34 8 56 56 CD cord-282990-qb4wk4yb 34 9 • • NN cord-282990-qb4wk4yb 34 10 C c NN cord-282990-qb4wk4yb 34 11 for for IN cord-282990-qb4wk4yb 34 12 30 30 CD cord-282990-qb4wk4yb 34 13 min min NN cord-282990-qb4wk4yb 34 14 was be VBD cord-282990-qb4wk4yb 34 15 sufficient sufficient JJ cord-282990-qb4wk4yb 34 16 to to TO cord-282990-qb4wk4yb 34 17 inactivate inactivate VB cord-282990-qb4wk4yb 34 18 the the DT cord-282990-qb4wk4yb 34 19 blood blood NN cord-282990-qb4wk4yb 34 20 specimens specimen NNS cord-282990-qb4wk4yb 34 21 with with IN cord-282990-qb4wk4yb 34 22 low low JJ cord-282990-qb4wk4yb 34 23 viral viral JJ cord-282990-qb4wk4yb 34 24 load load NN cord-282990-qb4wk4yb 34 25 [ [ -LRB- cord-282990-qb4wk4yb 34 26 12 12 CD cord-282990-qb4wk4yb 34 27 ] ] -RRB- cord-282990-qb4wk4yb 34 28 . . . cord-282990-qb4wk4yb 35 1 Nevertheless nevertheless RB cord-282990-qb4wk4yb 35 2 , , , cord-282990-qb4wk4yb 35 3 only only RB cord-282990-qb4wk4yb 35 4 the the DT cord-282990-qb4wk4yb 35 5 protocol protocol NN cord-282990-qb4wk4yb 35 6 of of IN cord-282990-qb4wk4yb 35 7 heating heating NN cord-282990-qb4wk4yb 35 8 at at IN cord-282990-qb4wk4yb 35 9 92 92 CD cord-282990-qb4wk4yb 35 10 • • NN cord-282990-qb4wk4yb 35 11 C C NNP cord-282990-qb4wk4yb 35 12 for for IN cord-282990-qb4wk4yb 35 13 15 15 CD cord-282990-qb4wk4yb 35 14 min min NN cord-282990-qb4wk4yb 35 15 completely completely RB cord-282990-qb4wk4yb 35 16 inactivated inactivate VBD cord-282990-qb4wk4yb 35 17 SARS SARS NNP cord-282990-qb4wk4yb 35 18 - - HYPH cord-282990-qb4wk4yb 35 19 CoV-2 CoV-2 NNP cord-282990-qb4wk4yb 35 20 in in IN cord-282990-qb4wk4yb 35 21 respiratory respiratory JJ cord-282990-qb4wk4yb 35 22 specimens specimen NNS cord-282990-qb4wk4yb 35 23 with with IN cord-282990-qb4wk4yb 35 24 much much RB cord-282990-qb4wk4yb 35 25 higher high JJR cord-282990-qb4wk4yb 35 26 viral viral JJ cord-282990-qb4wk4yb 35 27 load load NN cord-282990-qb4wk4yb 35 28 . . . cord-282990-qb4wk4yb 36 1 Since since IN cord-282990-qb4wk4yb 36 2 the the DT cord-282990-qb4wk4yb 36 3 detectable detectable JJ cord-282990-qb4wk4yb 36 4 viral viral JJ cord-282990-qb4wk4yb 36 5 RNA RNA NNP cord-282990-qb4wk4yb 36 6 was be VBD cord-282990-qb4wk4yb 36 7 also also RB cord-282990-qb4wk4yb 36 8 drastically drastically RB cord-282990-qb4wk4yb 36 9 reduced reduce VBN cord-282990-qb4wk4yb 36 10 under under IN cord-282990-qb4wk4yb 36 11 this this DT cord-282990-qb4wk4yb 36 12 condition condition NN cord-282990-qb4wk4yb 36 13 , , , cord-282990-qb4wk4yb 36 14 this this DT cord-282990-qb4wk4yb 36 15 protocol protocol NN cord-282990-qb4wk4yb 36 16 is be VBZ cord-282990-qb4wk4yb 36 17 not not RB cord-282990-qb4wk4yb 36 18 compatible compatible JJ cord-282990-qb4wk4yb 36 19 with with IN cord-282990-qb4wk4yb 36 20 subsequent subsequent JJ cord-282990-qb4wk4yb 36 21 reverse reverse JJ cord-282990-qb4wk4yb 36 22 transcription transcription NN cord-282990-qb4wk4yb 36 23 - - HYPH cord-282990-qb4wk4yb 36 24 polymerase polymerase NN cord-282990-qb4wk4yb 36 25 chain chain NN cord-282990-qb4wk4yb 36 26 reaction reaction NN cord-282990-qb4wk4yb 36 27 detection detection NN cord-282990-qb4wk4yb 36 28 ( ( -LRB- cord-282990-qb4wk4yb 36 29 if if IN cord-282990-qb4wk4yb 36 30 required require VBN cord-282990-qb4wk4yb 36 31 ) ) -RRB- cord-282990-qb4wk4yb 36 32 . . . cord-282990-qb4wk4yb 37 1 Among among IN cord-282990-qb4wk4yb 37 2 the the DT cord-282990-qb4wk4yb 37 3 various various JJ cord-282990-qb4wk4yb 37 4 chemical chemical NN cord-282990-qb4wk4yb 37 5 protocols protocol NNS cord-282990-qb4wk4yb 37 6 , , , cord-282990-qb4wk4yb 37 7 lysis lysis NN cord-282990-qb4wk4yb 37 8 buffer buffer NN cord-282990-qb4wk4yb 37 9 with with IN cord-282990-qb4wk4yb 37 10 detergent detergent NN cord-282990-qb4wk4yb 37 11 is be VBZ cord-282990-qb4wk4yb 37 12 the the DT cord-282990-qb4wk4yb 37 13 most most RBS cord-282990-qb4wk4yb 37 14 commonly commonly RB cord-282990-qb4wk4yb 37 15 employed employ VBN cord-282990-qb4wk4yb 37 16 . . . cord-282990-qb4wk4yb 38 1 Pastorino Pastorino NNP cord-282990-qb4wk4yb 38 2 et et FW cord-282990-qb4wk4yb 38 3 al al NNP cord-282990-qb4wk4yb 38 4 . . . cord-282990-qb4wk4yb 39 1 found find VBN cord-282990-qb4wk4yb 40 1 that that IN cord-282990-qb4wk4yb 40 2 1 1 CD cord-282990-qb4wk4yb 40 3 - - SYM cord-282990-qb4wk4yb 40 4 10 10 CD cord-282990-qb4wk4yb 40 5 % % NN cord-282990-qb4wk4yb 40 6 sodium sodium NN cord-282990-qb4wk4yb 40 7 dodecyl dodecyl NNP cord-282990-qb4wk4yb 40 8 sulfate sulfate NN cord-282990-qb4wk4yb 40 9 buffer buffer NN cord-282990-qb4wk4yb 40 10 or or CC cord-282990-qb4wk4yb 40 11 30 30 CD cord-282990-qb4wk4yb 40 12 - - SYM cord-282990-qb4wk4yb 40 13 50 50 CD cord-282990-qb4wk4yb 40 14 % % NN cord-282990-qb4wk4yb 40 15 guanidine guanidine JJ cord-282990-qb4wk4yb 40 16 hydrochloride/1 hydrochloride/1 NNPS cord-282990-qb4wk4yb 40 17 - - : cord-282990-qb4wk4yb 40 18 10 10 CD cord-282990-qb4wk4yb 40 19 % % NN cord-282990-qb4wk4yb 40 20 t t NN cord-282990-qb4wk4yb 40 21 - - HYPH cord-282990-qb4wk4yb 40 22 octylphenoxypolyethoxyethanol octylphenoxypolyethoxyethanol NNP cord-282990-qb4wk4yb 40 23 ( ( -LRB- cord-282990-qb4wk4yb 40 24 Triton Triton NNP cord-282990-qb4wk4yb 40 25 X-100 x-100 NN cord-282990-qb4wk4yb 40 26 ) ) -RRB- cord-282990-qb4wk4yb 40 27 effectively effectively RB cord-282990-qb4wk4yb 40 28 inactivated inactivate VBN cord-282990-qb4wk4yb 40 29 SARS SARS NNP cord-282990-qb4wk4yb 40 30 - - HYPH cord-282990-qb4wk4yb 40 31 CoV-2 CoV-2 NNP cord-282990-qb4wk4yb 40 32 with with IN cord-282990-qb4wk4yb 40 33 viral viral JJ cord-282990-qb4wk4yb 40 34 load load NN cord-282990-qb4wk4yb 40 35 as as RB cord-282990-qb4wk4yb 40 36 high high JJ cord-282990-qb4wk4yb 40 37 as as IN cord-282990-qb4wk4yb 40 38 10 10 CD cord-282990-qb4wk4yb 40 39 6 6 CD cord-282990-qb4wk4yb 40 40 TCID TCID NNP cord-282990-qb4wk4yb 40 41 50 50 CD cord-282990-qb4wk4yb 40 42 /ml /ml . cord-282990-qb4wk4yb 41 1 [ [ -LRB- cord-282990-qb4wk4yb 41 2 12 12 CD cord-282990-qb4wk4yb 41 3 ] ] -RRB- cord-282990-qb4wk4yb 41 4 . . . cord-282990-qb4wk4yb 42 1 Some some DT cord-282990-qb4wk4yb 42 2 protocols protocol NNS cord-282990-qb4wk4yb 42 3 utilized utilize VBD cord-282990-qb4wk4yb 42 4 reducing reduce VBG cord-282990-qb4wk4yb 42 5 reagents reagent NNS cord-282990-qb4wk4yb 42 6 to to TO cord-282990-qb4wk4yb 42 7 denature denature VB cord-282990-qb4wk4yb 42 8 viral viral JJ cord-282990-qb4wk4yb 42 9 proteins protein NNS cord-282990-qb4wk4yb 42 10 by by IN cord-282990-qb4wk4yb 42 11 reducing reduce VBG cord-282990-qb4wk4yb 42 12 disulfide disulfide JJ cord-282990-qb4wk4yb 42 13 bridges bridge NNS cord-282990-qb4wk4yb 42 14 . . . cord-282990-qb4wk4yb 43 1 For for IN cord-282990-qb4wk4yb 43 2 instance instance NN cord-282990-qb4wk4yb 43 3 , , , cord-282990-qb4wk4yb 43 4 a a DT cord-282990-qb4wk4yb 43 5 shelf shelf NN cord-282990-qb4wk4yb 43 6 - - HYPH cord-282990-qb4wk4yb 43 7 stable stable JJ cord-282990-qb4wk4yb 43 8 reducing reduce VBG cord-282990-qb4wk4yb 43 9 agent agent NN cord-282990-qb4wk4yb 43 10 tris(2-carboxyethyl)phosphine tris(2-carboxyethyl)phosphine NNP cord-282990-qb4wk4yb 43 11 was be VBD cord-282990-qb4wk4yb 43 12 used use VBN cord-282990-qb4wk4yb 43 13 for for IN cord-282990-qb4wk4yb 43 14 SARS SARS NNP cord-282990-qb4wk4yb 43 15 - - HYPH cord-282990-qb4wk4yb 43 16 CoV-2 CoV-2 NNP cord-282990-qb4wk4yb 43 17 inactivation inactivation NN cord-282990-qb4wk4yb 43 18 when when WRB cord-282990-qb4wk4yb 43 19 mixed mix VBN cord-282990-qb4wk4yb 43 20 with with IN cord-282990-qb4wk4yb 43 21 the the DT cord-282990-qb4wk4yb 43 22 divalent divalent JJ cord-282990-qb4wk4yb 43 23 cation cation NN cord-282990-qb4wk4yb 43 24 chelator chelator NN cord-282990-qb4wk4yb 43 25 EDTA EDTA NNP cord-282990-qb4wk4yb 43 26 and and CC cord-282990-qb4wk4yb 43 27 heated heat VBD cord-282990-qb4wk4yb 43 28 at at IN cord-282990-qb4wk4yb 43 29 95 95 CD cord-282990-qb4wk4yb 43 30 • • NN cord-282990-qb4wk4yb 43 31 C c NN cord-282990-qb4wk4yb 43 32 for for IN cord-282990-qb4wk4yb 43 33 a a DT cord-282990-qb4wk4yb 43 34 brief brief JJ cord-282990-qb4wk4yb 43 35 period period NN cord-282990-qb4wk4yb 43 36 ( ( -LRB- cord-282990-qb4wk4yb 43 37 5 5 CD cord-282990-qb4wk4yb 43 38 min min NN cord-282990-qb4wk4yb 43 39 ) ) -RRB- cord-282990-qb4wk4yb 43 40 [ [ -LRB- cord-282990-qb4wk4yb 43 41 13 13 CD cord-282990-qb4wk4yb 43 42 ] ] -RRB- cord-282990-qb4wk4yb 43 43 . . . cord-282990-qb4wk4yb 44 1 This this DT cord-282990-qb4wk4yb 44 2 protocol protocol NN cord-282990-qb4wk4yb 44 3 rapidly rapidly RB cord-282990-qb4wk4yb 44 4 denatures denature VBZ cord-282990-qb4wk4yb 44 5 proteins protein NNS cord-282990-qb4wk4yb 44 6 while while IN cord-282990-qb4wk4yb 44 7 protecting protect VBG cord-282990-qb4wk4yb 44 8 the the DT cord-282990-qb4wk4yb 44 9 viral viral JJ cord-282990-qb4wk4yb 44 10 RNA RNA NNP cord-282990-qb4wk4yb 44 11 from from IN cord-282990-qb4wk4yb 44 12 the the DT cord-282990-qb4wk4yb 44 13 degradation degradation NN cord-282990-qb4wk4yb 44 14 by by IN cord-282990-qb4wk4yb 44 15 endogenous endogenous JJ cord-282990-qb4wk4yb 44 16 RNases rnase NNS cord-282990-qb4wk4yb 44 17 . . . cord-282990-qb4wk4yb 45 1 The the DT cord-282990-qb4wk4yb 45 2 addition addition NN cord-282990-qb4wk4yb 45 3 of of IN cord-282990-qb4wk4yb 45 4 EDTA EDTA NNP cord-282990-qb4wk4yb 45 5 sequesters sequester VBZ cord-282990-qb4wk4yb 45 6 any any DT cord-282990-qb4wk4yb 45 7 divalent divalent JJ cord-282990-qb4wk4yb 45 8 cations cation NNS cord-282990-qb4wk4yb 45 9 that that WDT cord-282990-qb4wk4yb 45 10 are be VBP cord-282990-qb4wk4yb 45 11 released release VBN cord-282990-qb4wk4yb 45 12 from from IN cord-282990-qb4wk4yb 45 13 denatured denatured JJ cord-282990-qb4wk4yb 45 14 proteins protein NNS cord-282990-qb4wk4yb 45 15 and and CC cord-282990-qb4wk4yb 45 16 that that WDT cord-282990-qb4wk4yb 45 17 are be VBP cord-282990-qb4wk4yb 45 18 required require VBN cord-282990-qb4wk4yb 45 19 for for IN cord-282990-qb4wk4yb 45 20 RNase rnase NN cord-282990-qb4wk4yb 45 21 activity activity NN cord-282990-qb4wk4yb 45 22 . . . cord-282990-qb4wk4yb 46 1 Some some DT cord-282990-qb4wk4yb 46 2 photochemical photochemical JJ cord-282990-qb4wk4yb 46 3 protocols protocol NNS cord-282990-qb4wk4yb 46 4 are be VBP cord-282990-qb4wk4yb 46 5 also also RB cord-282990-qb4wk4yb 46 6 applicable applicable JJ cord-282990-qb4wk4yb 46 7 , , , cord-282990-qb4wk4yb 46 8 such such JJ cord-282990-qb4wk4yb 46 9 as as IN cord-282990-qb4wk4yb 46 10 treatment treatment NN cord-282990-qb4wk4yb 46 11 with with IN cord-282990-qb4wk4yb 46 12 riboflavin riboflavin NN cord-282990-qb4wk4yb 46 13 / / SYM cord-282990-qb4wk4yb 46 14 ultraviolet ultraviolet NN cord-282990-qb4wk4yb 46 15 light light NN cord-282990-qb4wk4yb 46 16 [ [ -LRB- cord-282990-qb4wk4yb 46 17 14 14 CD cord-282990-qb4wk4yb 46 18 ] ] -RRB- cord-282990-qb4wk4yb 46 19 or or CC cord-282990-qb4wk4yb 46 20 methylene methylene NN cord-282990-qb4wk4yb 46 21 blue blue JJ cord-282990-qb4wk4yb 46 22 / / SYM cord-282990-qb4wk4yb 46 23 visible visible JJ cord-282990-qb4wk4yb 46 24 light light NN cord-282990-qb4wk4yb 46 25 [ [ -LRB- cord-282990-qb4wk4yb 46 26 15 15 CD cord-282990-qb4wk4yb 46 27 ] ] -RRB- cord-282990-qb4wk4yb 46 28 . . . cord-282990-qb4wk4yb 47 1 However however RB cord-282990-qb4wk4yb 47 2 , , , cord-282990-qb4wk4yb 47 3 the the DT cord-282990-qb4wk4yb 47 4 photochemical photochemical JJ cord-282990-qb4wk4yb 47 5 protocol protocol NN cord-282990-qb4wk4yb 47 6 may may MD cord-282990-qb4wk4yb 47 7 require require VB cord-282990-qb4wk4yb 47 8 specialized specialized JJ cord-282990-qb4wk4yb 47 9 equipment equipment NN cord-282990-qb4wk4yb 47 10 not not RB cord-282990-qb4wk4yb 47 11 available available JJ cord-282990-qb4wk4yb 47 12 in in IN cord-282990-qb4wk4yb 47 13 all all DT cord-282990-qb4wk4yb 47 14 laboratories laboratory NNS cord-282990-qb4wk4yb 47 15 . . . cord-282990-qb4wk4yb 48 1 It -PRON- PRP cord-282990-qb4wk4yb 48 2 is be VBZ cord-282990-qb4wk4yb 48 3 worth worth JJ cord-282990-qb4wk4yb 48 4 noting note VBG cord-282990-qb4wk4yb 48 5 that that IN cord-282990-qb4wk4yb 48 6 both both CC cord-282990-qb4wk4yb 48 7 heating heating NN cord-282990-qb4wk4yb 48 8 and and CC cord-282990-qb4wk4yb 48 9 chemical chemical NN cord-282990-qb4wk4yb 48 10 protocols protocol NNS cord-282990-qb4wk4yb 48 11 may may MD cord-282990-qb4wk4yb 48 12 denature denature VB cord-282990-qb4wk4yb 48 13 the the DT cord-282990-qb4wk4yb 48 14 protein protein NN cord-282990-qb4wk4yb 48 15 analyte analyte NN cord-282990-qb4wk4yb 48 16 of of IN cord-282990-qb4wk4yb 48 17 interest interest NN cord-282990-qb4wk4yb 48 18 in in IN cord-282990-qb4wk4yb 48 19 a a DT cord-282990-qb4wk4yb 48 20 bioanalytical bioanalytical JJ cord-282990-qb4wk4yb 48 21 assay assay NN cord-282990-qb4wk4yb 48 22 , , , cord-282990-qb4wk4yb 48 23 resulting result VBG cord-282990-qb4wk4yb 48 24 in in IN cord-282990-qb4wk4yb 48 25 measurement measurement NN cord-282990-qb4wk4yb 48 26 bias bias NN cord-282990-qb4wk4yb 48 27 or or CC cord-282990-qb4wk4yb 48 28 false false JJ cord-282990-qb4wk4yb 48 29 - - HYPH cord-282990-qb4wk4yb 48 30 negative negative JJ cord-282990-qb4wk4yb 48 31 results result NNS cord-282990-qb4wk4yb 48 32 . . . cord-282990-qb4wk4yb 49 1 For for IN cord-282990-qb4wk4yb 49 2 example example NN cord-282990-qb4wk4yb 49 3 , , , cord-282990-qb4wk4yb 49 4 a a DT cord-282990-qb4wk4yb 49 5 paper paper NN cord-282990-qb4wk4yb 49 6 demonstrated demonstrate VBD cord-282990-qb4wk4yb 49 7 that that IN cord-282990-qb4wk4yb 49 8 heat heat NN cord-282990-qb4wk4yb 49 9 inactivation inactivation NN cord-282990-qb4wk4yb 49 10 of of IN cord-282990-qb4wk4yb 49 11 serum serum NN cord-282990-qb4wk4yb 49 12 at at IN cord-282990-qb4wk4yb 49 13 56 56 CD cord-282990-qb4wk4yb 50 1 • • NNP cord-282990-qb4wk4yb 50 2 C C NNP cord-282990-qb4wk4yb 50 3 for for IN cord-282990-qb4wk4yb 50 4 30 30 CD cord-282990-qb4wk4yb 50 5 min min NN cord-282990-qb4wk4yb 50 6 significantly significantly RB cord-282990-qb4wk4yb 50 7 interfered interfere VBD cord-282990-qb4wk4yb 50 8 with with IN cord-282990-qb4wk4yb 50 9 the the DT cord-282990-qb4wk4yb 50 10 quantitation quantitation NN cord-282990-qb4wk4yb 50 11 of of IN cord-282990-qb4wk4yb 50 12 antibodies antibody NNS cord-282990-qb4wk4yb 50 13 to to IN cord-282990-qb4wk4yb 50 14 SARS SARS NNP cord-282990-qb4wk4yb 50 15 - - HYPH cord-282990-qb4wk4yb 50 16 CoV-2 CoV-2 NNP cord-282990-qb4wk4yb 50 17 in in IN cord-282990-qb4wk4yb 50 18 a a DT cord-282990-qb4wk4yb 50 19 fluorescence fluorescence NN cord-282990-qb4wk4yb 50 20 immunochromatographic immunochromatographic JJ cord-282990-qb4wk4yb 50 21 assay assay NN cord-282990-qb4wk4yb 50 22 [ [ -LRB- cord-282990-qb4wk4yb 50 23 16 16 CD cord-282990-qb4wk4yb 50 24 ] ] -RRB- cord-282990-qb4wk4yb 50 25 . . . cord-282990-qb4wk4yb 51 1 Of of IN cord-282990-qb4wk4yb 51 2 the the DT cord-282990-qb4wk4yb 51 3 34 34 CD cord-282990-qb4wk4yb 51 4 serum serum NN cord-282990-qb4wk4yb 51 5 samples sample NNS cord-282990-qb4wk4yb 51 6 from from IN cord-282990-qb4wk4yb 51 7 COVID-19 covid-19 CD cord-282990-qb4wk4yb 51 8 patients patient NNS cord-282990-qb4wk4yb 51 9 , , , cord-282990-qb4wk4yb 51 10 the the DT cord-282990-qb4wk4yb 51 11 IgG igg NN cord-282990-qb4wk4yb 51 12 levels level NNS cord-282990-qb4wk4yb 51 13 in in IN cord-282990-qb4wk4yb 51 14 24 24 CD cord-282990-qb4wk4yb 51 15 samples sample NNS cord-282990-qb4wk4yb 51 16 dropped drop VBN cord-282990-qb4wk4yb 51 17 by by IN cord-282990-qb4wk4yb 51 18 an an DT cord-282990-qb4wk4yb 51 19 average average JJ cord-282990-qb4wk4yb 51 20 level level NN cord-282990-qb4wk4yb 51 21 of of IN cord-282990-qb4wk4yb 51 22 49.54 49.54 CD cord-282990-qb4wk4yb 51 23 % % NN cord-282990-qb4wk4yb 51 24 . . . cord-282990-qb4wk4yb 52 1 The the DT cord-282990-qb4wk4yb 52 2 IgM igm NN cord-282990-qb4wk4yb 52 3 levels level NNS cord-282990-qb4wk4yb 52 4 of of IN cord-282990-qb4wk4yb 52 5 all all DT cord-282990-qb4wk4yb 52 6 34 34 CD cord-282990-qb4wk4yb 52 7 samples sample NNS cord-282990-qb4wk4yb 52 8 decreased decrease VBD cord-282990-qb4wk4yb 52 9 by by IN cord-282990-qb4wk4yb 52 10 an an DT cord-282990-qb4wk4yb 52 11 average average JJ cord-282990-qb4wk4yb 52 12 level level NN cord-282990-qb4wk4yb 52 13 of of IN cord-282990-qb4wk4yb 52 14 53.56 53.56 CD cord-282990-qb4wk4yb 52 15 % % NN cord-282990-qb4wk4yb 52 16 . . . cord-282990-qb4wk4yb 53 1 Moreover moreover RB cord-282990-qb4wk4yb 53 2 , , , cord-282990-qb4wk4yb 53 3 44.12 44.12 CD cord-282990-qb4wk4yb 53 4 % % NN cord-282990-qb4wk4yb 53 5 of of IN cord-282990-qb4wk4yb 53 6 the the DT cord-282990-qb4wk4yb 53 7 IgM IgM NNP cord-282990-qb4wk4yb 53 8 signals signal NNS cord-282990-qb4wk4yb 53 9 reduced reduce VBN cord-282990-qb4wk4yb 53 10 below below IN cord-282990-qb4wk4yb 53 11 the the DT cord-282990-qb4wk4yb 53 12 cut cut VB cord-282990-qb4wk4yb 53 13 - - HYPH cord-282990-qb4wk4yb 53 14 off off RP cord-282990-qb4wk4yb 53 15 value value NN cord-282990-qb4wk4yb 53 16 after after IN cord-282990-qb4wk4yb 53 17 heating heating NN cord-282990-qb4wk4yb 53 18 , , , cord-282990-qb4wk4yb 53 19 indicating indicate VBG cord-282990-qb4wk4yb 53 20 that that IN cord-282990-qb4wk4yb 53 21 the the DT cord-282990-qb4wk4yb 53 22 false false JJ cord-282990-qb4wk4yb 53 23 - - HYPH cord-282990-qb4wk4yb 53 24 negative negative JJ cord-282990-qb4wk4yb 53 25 results result NNS cord-282990-qb4wk4yb 53 26 were be VBD cord-282990-qb4wk4yb 53 27 caused cause VBN cord-282990-qb4wk4yb 53 28 by by IN cord-282990-qb4wk4yb 53 29 the the DT cord-282990-qb4wk4yb 53 30 heat heat NN cord-282990-qb4wk4yb 53 31 inactivation inactivation NN cord-282990-qb4wk4yb 53 32 . . . cord-282990-qb4wk4yb 54 1 Therefore therefore RB cord-282990-qb4wk4yb 54 2 , , , cord-282990-qb4wk4yb 54 3 the the DT cord-282990-qb4wk4yb 54 4 possibility possibility NN cord-282990-qb4wk4yb 54 5 of of IN cord-282990-qb4wk4yb 54 6 analyte analyte JJ cord-282990-qb4wk4yb 54 7 denaturation denaturation NN cord-282990-qb4wk4yb 54 8 and and CC cord-282990-qb4wk4yb 54 9 its -PRON- PRP$ cord-282990-qb4wk4yb 54 10 impact impact NN cord-282990-qb4wk4yb 54 11 on on IN cord-282990-qb4wk4yb 54 12 the the DT cord-282990-qb4wk4yb 54 13 accuracy accuracy NN cord-282990-qb4wk4yb 54 14 of of IN cord-282990-qb4wk4yb 54 15 immunoassays immunoassays NNP cord-282990-qb4wk4yb 54 16 or or CC cord-282990-qb4wk4yb 54 17 other other JJ cord-282990-qb4wk4yb 54 18 bioanalytical bioanalytical JJ cord-282990-qb4wk4yb 54 19 techniques technique NNS cord-282990-qb4wk4yb 54 20 should should MD cord-282990-qb4wk4yb 54 21 be be VB cord-282990-qb4wk4yb 54 22 considered consider VBN cord-282990-qb4wk4yb 54 23 when when WRB cord-282990-qb4wk4yb 54 24 introducing introduce VBG cord-282990-qb4wk4yb 54 25 an an DT cord-282990-qb4wk4yb 54 26 inactivation inactivation NN cord-282990-qb4wk4yb 54 27 protocol protocol NN cord-282990-qb4wk4yb 54 28 . . . cord-282990-qb4wk4yb 55 1 Peptide peptide NN cord-282990-qb4wk4yb 55 2 - - HYPH cord-282990-qb4wk4yb 55 3 based base VBN cord-282990-qb4wk4yb 55 4 LC LC NNP cord-282990-qb4wk4yb 55 5 - - HYPH cord-282990-qb4wk4yb 55 6 MS MS NNP cord-282990-qb4wk4yb 55 7 assay assay NN cord-282990-qb4wk4yb 55 8 is be VBZ cord-282990-qb4wk4yb 55 9 compatible compatible JJ cord-282990-qb4wk4yb 55 10 with with IN cord-282990-qb4wk4yb 55 11 protein protein NN cord-282990-qb4wk4yb 55 12 denaturation denaturation NN cord-282990-qb4wk4yb 55 13 and and CC cord-282990-qb4wk4yb 55 14 can can MD cord-282990-qb4wk4yb 55 15 therefore therefore RB cord-282990-qb4wk4yb 55 16 be be VB cord-282990-qb4wk4yb 55 17 considered consider VBN cord-282990-qb4wk4yb 55 18 as as IN cord-282990-qb4wk4yb 55 19 an an DT cord-282990-qb4wk4yb 55 20 alternative alternative JJ cord-282990-qb4wk4yb 55 21 approach approach NN cord-282990-qb4wk4yb 55 22 for for IN cord-282990-qb4wk4yb 55 23 the the DT cord-282990-qb4wk4yb 55 24 analysis analysis NN cord-282990-qb4wk4yb 55 25 of of IN cord-282990-qb4wk4yb 55 26 proteins protein NNS cord-282990-qb4wk4yb 55 27 from from IN cord-282990-qb4wk4yb 55 28 inactivated inactivate VBN cord-282990-qb4wk4yb 55 29 samples sample NNS cord-282990-qb4wk4yb 55 30 . . . cord-282990-qb4wk4yb 56 1 The the DT cord-282990-qb4wk4yb 56 2 latest late JJS cord-282990-qb4wk4yb 56 3 guidelines guideline NNS cord-282990-qb4wk4yb 56 4 by by IN cord-282990-qb4wk4yb 56 5 the the DT cord-282990-qb4wk4yb 56 6 National National NNP cord-282990-qb4wk4yb 56 7 Institutes Institutes NNPS cord-282990-qb4wk4yb 56 8 of of IN cord-282990-qb4wk4yb 56 9 Health Health NNP cord-282990-qb4wk4yb 56 10 ( ( -LRB- cord-282990-qb4wk4yb 56 11 NIH NIH NNP cord-282990-qb4wk4yb 56 12 ) ) -RRB- cord-282990-qb4wk4yb 56 13 classified classify VBN cord-282990-qb4wk4yb 56 14 SARS SARS NNP cord-282990-qb4wk4yb 56 15 - - HYPH cord-282990-qb4wk4yb 56 16 CoV CoV NNP cord-282990-qb4wk4yb 56 17 and and CC cord-282990-qb4wk4yb 56 18 MERS MERS NNP cord-282990-qb4wk4yb 56 19 - - HYPH cord-282990-qb4wk4yb 56 20 CoV CoV NNP cord-282990-qb4wk4yb 56 21 as as IN cord-282990-qb4wk4yb 56 22 risk risk NN cord-282990-qb4wk4yb 56 23 group group NN cord-282990-qb4wk4yb 56 24 3 3 CD cord-282990-qb4wk4yb 56 25 agents agent NNS cord-282990-qb4wk4yb 56 26 and and CC cord-282990-qb4wk4yb 56 27 other other JJ cord-282990-qb4wk4yb 56 28 coronaviruses coronaviruse NNS cord-282990-qb4wk4yb 56 29 as as IN cord-282990-qb4wk4yb 56 30 risk risk NN cord-282990-qb4wk4yb 56 31 group group NN cord-282990-qb4wk4yb 56 32 2 2 CD cord-282990-qb4wk4yb 56 33 agents agent NNS cord-282990-qb4wk4yb 56 34 [ [ -LRB- cord-282990-qb4wk4yb 56 35 17 17 CD cord-282990-qb4wk4yb 56 36 ] ] -RRB- cord-282990-qb4wk4yb 56 37 . . . cord-282990-qb4wk4yb 57 1 This this DT cord-282990-qb4wk4yb 57 2 classification classification NN cord-282990-qb4wk4yb 57 3 was be VBD cord-282990-qb4wk4yb 57 4 released release VBN cord-282990-qb4wk4yb 57 5 before before IN cord-282990-qb4wk4yb 57 6 the the DT cord-282990-qb4wk4yb 57 7 emergence emergence NN cord-282990-qb4wk4yb 57 8 of of IN cord-282990-qb4wk4yb 57 9 SARS SARS NNP cord-282990-qb4wk4yb 57 10 - - HYPH cord-282990-qb4wk4yb 57 11 CoV-2 CoV-2 NNP cord-282990-qb4wk4yb 57 12 , , , cord-282990-qb4wk4yb 57 13 but but CC cord-282990-qb4wk4yb 57 14 the the DT cord-282990-qb4wk4yb 57 15 consensus consensus NN cord-282990-qb4wk4yb 57 16 is be VBZ cord-282990-qb4wk4yb 57 17 to to TO cord-282990-qb4wk4yb 57 18 classify classify VB cord-282990-qb4wk4yb 57 19 SARS SARS NNP cord-282990-qb4wk4yb 57 20 - - HYPH cord-282990-qb4wk4yb 57 21 CoV-2 CoV-2 NNP cord-282990-qb4wk4yb 57 22 as as IN cord-282990-qb4wk4yb 57 23 a a DT cord-282990-qb4wk4yb 57 24 risk risk NN cord-282990-qb4wk4yb 57 25 group group NN cord-282990-qb4wk4yb 57 26 3 3 CD cord-282990-qb4wk4yb 57 27 agent agent NN cord-282990-qb4wk4yb 57 28 . . . cord-282990-qb4wk4yb 58 1 Based base VBN cord-282990-qb4wk4yb 58 2 on on IN cord-282990-qb4wk4yb 58 3 this this DT cord-282990-qb4wk4yb 58 4 classification classification NN cord-282990-qb4wk4yb 58 5 , , , cord-282990-qb4wk4yb 58 6 the the DT cord-282990-qb4wk4yb 58 7 interim interim JJ cord-282990-qb4wk4yb 58 8 guidelines guideline NNS cord-282990-qb4wk4yb 58 9 from from IN cord-282990-qb4wk4yb 58 10 both both DT cord-282990-qb4wk4yb 58 11 WHO who WP cord-282990-qb4wk4yb 58 12 [ [ -LRB- cord-282990-qb4wk4yb 58 13 18 18 CD cord-282990-qb4wk4yb 58 14 ] ] -RRB- cord-282990-qb4wk4yb 58 15 and and CC cord-282990-qb4wk4yb 58 16 CDC CDC NNP cord-282990-qb4wk4yb 58 17 [ [ -LRB- cord-282990-qb4wk4yb 58 18 10 10 CD cord-282990-qb4wk4yb 58 19 ] ] -RRB- cord-282990-qb4wk4yb 58 20 recommend recommend VBP cord-282990-qb4wk4yb 58 21 that that IN cord-282990-qb4wk4yb 58 22 nonpropagative nonpropagative JJ cord-282990-qb4wk4yb 58 23 laboratory laboratory NN cord-282990-qb4wk4yb 58 24 work work NN cord-282990-qb4wk4yb 58 25 on on IN cord-282990-qb4wk4yb 58 26 clinical clinical JJ cord-282990-qb4wk4yb 58 27 specimens specimen NNS cord-282990-qb4wk4yb 58 28 from from IN cord-282990-qb4wk4yb 58 29 patients patient NNS cord-282990-qb4wk4yb 58 30 who who WP cord-282990-qb4wk4yb 58 31 are be VBP cord-282990-qb4wk4yb 58 32 suspected suspect VBN cord-282990-qb4wk4yb 58 33 or or CC cord-282990-qb4wk4yb 58 34 confirmed confirm VBN cord-282990-qb4wk4yb 58 35 to to TO cord-282990-qb4wk4yb 58 36 be be VB cord-282990-qb4wk4yb 58 37 infected infect VBN cord-282990-qb4wk4yb 58 38 with with IN cord-282990-qb4wk4yb 58 39 COVID-19 COVID-19 NNP cord-282990-qb4wk4yb 58 40 should should MD cord-282990-qb4wk4yb 58 41 be be VB cord-282990-qb4wk4yb 58 42 conducted conduct VBN cord-282990-qb4wk4yb 58 43 in in IN cord-282990-qb4wk4yb 58 44 the the DT cord-282990-qb4wk4yb 58 45 Biosafety Biosafety NNP cord-282990-qb4wk4yb 58 46 Level Level NNP cord-282990-qb4wk4yb 58 47 2 2 CD cord-282990-qb4wk4yb 58 48 ( ( -LRB- cord-282990-qb4wk4yb 58 49 BSL-2 BSL-2 NNP cord-282990-qb4wk4yb 58 50 ) ) -RRB- cord-282990-qb4wk4yb 58 51 laboratory laboratory NN cord-282990-qb4wk4yb 58 52 . . . cord-282990-qb4wk4yb 59 1 Biosafety Biosafety NNP cord-282990-qb4wk4yb 59 2 Level Level NNP cord-282990-qb4wk4yb 59 3 3 3 CD cord-282990-qb4wk4yb 59 4 laboratory laboratory NN cord-282990-qb4wk4yb 59 5 is be VBZ cord-282990-qb4wk4yb 59 6 required require VBN cord-282990-qb4wk4yb 59 7 for for IN cord-282990-qb4wk4yb 59 8 propagative propagative JJ cord-282990-qb4wk4yb 59 9 work work NN cord-282990-qb4wk4yb 59 10 ( ( -LRB- cord-282990-qb4wk4yb 59 11 e.g. e.g. RB cord-282990-qb4wk4yb 59 12 , , , cord-282990-qb4wk4yb 59 13 virus virus NN cord-282990-qb4wk4yb 59 14 culture culture NN cord-282990-qb4wk4yb 59 15 or or CC cord-282990-qb4wk4yb 59 16 neutralization neutralization NN cord-282990-qb4wk4yb 59 17 assays assay NNS cord-282990-qb4wk4yb 59 18 ) ) -RRB- cord-282990-qb4wk4yb 59 19 when when WRB cord-282990-qb4wk4yb 59 20 handling handle VBG cord-282990-qb4wk4yb 59 21 materials material NNS cord-282990-qb4wk4yb 59 22 with with IN cord-282990-qb4wk4yb 59 23 high high JJ cord-282990-qb4wk4yb 59 24 concentration concentration NN cord-282990-qb4wk4yb 59 25 of of IN cord-282990-qb4wk4yb 59 26 live live JJ cord-282990-qb4wk4yb 59 27 SARS SARS NNP cord-282990-qb4wk4yb 59 28 - - HYPH cord-282990-qb4wk4yb 59 29 CoV-2 CoV-2 NNP cord-282990-qb4wk4yb 59 30 virus virus NN cord-282990-qb4wk4yb 59 31 . . . cord-282990-qb4wk4yb 60 1 Therefore therefore RB cord-282990-qb4wk4yb 60 2 , , , cord-282990-qb4wk4yb 60 3 bioanalysis bioanalysis NN cord-282990-qb4wk4yb 60 4 of of IN cord-282990-qb4wk4yb 60 5 COVID-19 covid-19 JJ cord-282990-qb4wk4yb 60 6 patient patient NN cord-282990-qb4wk4yb 60 7 samples sample NNS cord-282990-qb4wk4yb 60 8 , , , cord-282990-qb4wk4yb 60 9 including include VBG cord-282990-qb4wk4yb 60 10 both both DT cord-282990-qb4wk4yb 60 11 respiratory respiratory JJ cord-282990-qb4wk4yb 60 12 specimens specimen NNS cord-282990-qb4wk4yb 60 13 and and CC cord-282990-qb4wk4yb 60 14 nonrespiratory nonrespiratory NN cord-282990-qb4wk4yb 60 15 specimens specimen NNS cord-282990-qb4wk4yb 60 16 , , , cord-282990-qb4wk4yb 60 17 should should MD cord-282990-qb4wk4yb 60 18 be be VB cord-282990-qb4wk4yb 60 19 performed perform VBN cord-282990-qb4wk4yb 60 20 in in IN cord-282990-qb4wk4yb 60 21 a a DT cord-282990-qb4wk4yb 60 22 BSL-2 BSL-2 NNP cord-282990-qb4wk4yb 60 23 laboratory laboratory NN cord-282990-qb4wk4yb 60 24 [ [ -LRB- cord-282990-qb4wk4yb 60 25 8 8 CD cord-282990-qb4wk4yb 60 26 ] ] -RRB- cord-282990-qb4wk4yb 60 27 . . . cord-282990-qb4wk4yb 61 1 In in IN cord-282990-qb4wk4yb 61 2 addition addition NN cord-282990-qb4wk4yb 61 3 , , , cord-282990-qb4wk4yb 61 4 the the DT cord-282990-qb4wk4yb 61 5 CDC CDC NNP cord-282990-qb4wk4yb 61 6 guidelines guideline NNS cord-282990-qb4wk4yb 61 7 recommended recommend VBD cord-282990-qb4wk4yb 61 8 the the DT cord-282990-qb4wk4yb 61 9 site site NN cord-282990-qb4wk4yb 61 10 - - HYPH cord-282990-qb4wk4yb 61 11 specific specific JJ cord-282990-qb4wk4yb 61 12 and and CC cord-282990-qb4wk4yb 61 13 activity activity NN cord-282990-qb4wk4yb 61 14 - - HYPH cord-282990-qb4wk4yb 61 15 specific specific JJ cord-282990-qb4wk4yb 61 16 biosafety biosafety NN cord-282990-qb4wk4yb 61 17 risk risk NN cord-282990-qb4wk4yb 61 18 assessments assessment NNS cord-282990-qb4wk4yb 61 19 to to TO cord-282990-qb4wk4yb 61 20 determine determine VB cord-282990-qb4wk4yb 61 21 whether whether IN cord-282990-qb4wk4yb 61 22 additional additional JJ cord-282990-qb4wk4yb 61 23 biosafety biosafety NN cord-282990-qb4wk4yb 61 24 precautions precaution NNS cord-282990-qb4wk4yb 61 25 should should MD cord-282990-qb4wk4yb 61 26 be be VB cord-282990-qb4wk4yb 61 27 taken take VBN cord-282990-qb4wk4yb 61 28 based base VBN cord-282990-qb4wk4yb 61 29 on on IN cord-282990-qb4wk4yb 61 30 situational situational JJ cord-282990-qb4wk4yb 61 31 needs need NNS cord-282990-qb4wk4yb 61 32 . . . cord-282990-qb4wk4yb 62 1 Also also RB cord-282990-qb4wk4yb 62 2 , , , cord-282990-qb4wk4yb 62 3 local local JJ cord-282990-qb4wk4yb 62 4 regulations regulation NNS cord-282990-qb4wk4yb 62 5 need need VBP cord-282990-qb4wk4yb 62 6 to to TO cord-282990-qb4wk4yb 62 7 be be VB cord-282990-qb4wk4yb 62 8 complied comply VBN cord-282990-qb4wk4yb 62 9 , , , cord-282990-qb4wk4yb 62 10 if if IN cord-282990-qb4wk4yb 62 11 certain certain JJ cord-282990-qb4wk4yb 62 12 countries country NNS cord-282990-qb4wk4yb 62 13 or or CC cord-282990-qb4wk4yb 62 14 regions region NNS cord-282990-qb4wk4yb 62 15 have have VBP cord-282990-qb4wk4yb 62 16 unique unique JJ cord-282990-qb4wk4yb 62 17 or or CC cord-282990-qb4wk4yb 62 18 specific specific JJ cord-282990-qb4wk4yb 62 19 requirements requirement NNS cord-282990-qb4wk4yb 62 20 for for IN cord-282990-qb4wk4yb 62 21 handling handle VBG cord-282990-qb4wk4yb 62 22 samples sample NNS cord-282990-qb4wk4yb 62 23 from from IN cord-282990-qb4wk4yb 62 24 COVID-19 covid-19 CD cord-282990-qb4wk4yb 62 25 patients patient NNS cord-282990-qb4wk4yb 62 26 . . . cord-282990-qb4wk4yb 63 1 A a DT cord-282990-qb4wk4yb 63 2 paper paper NN cord-282990-qb4wk4yb 63 3 by by IN cord-282990-qb4wk4yb 63 4 Cossarizza Cossarizza NNP cord-282990-qb4wk4yb 63 5 et et NNP cord-282990-qb4wk4yb 63 6 al al NNP cord-282990-qb4wk4yb 63 7 . . . cord-282990-qb4wk4yb 64 1 [ [ -LRB- cord-282990-qb4wk4yb 64 2 9 9 CD cord-282990-qb4wk4yb 64 3 ] ] -RRB- cord-282990-qb4wk4yb 64 4 described describe VBD cord-282990-qb4wk4yb 64 5 the the DT cord-282990-qb4wk4yb 64 6 procedures procedure NNS cord-282990-qb4wk4yb 64 7 they -PRON- PRP cord-282990-qb4wk4yb 64 8 followed follow VBD cord-282990-qb4wk4yb 64 9 for for IN cord-282990-qb4wk4yb 64 10 processing process VBG cord-282990-qb4wk4yb 64 11 blood blood NN cord-282990-qb4wk4yb 64 12 specimens specimen NNS cord-282990-qb4wk4yb 64 13 from from IN cord-282990-qb4wk4yb 64 14 COVID-19 covid-19 CD cord-282990-qb4wk4yb 64 15 patients patient NNS cord-282990-qb4wk4yb 64 16 : : : cord-282990-qb4wk4yb 64 17 the the DT cord-282990-qb4wk4yb 64 18 patient patient NN cord-282990-qb4wk4yb 64 19 's 's POS cord-282990-qb4wk4yb 64 20 blood blood NN cord-282990-qb4wk4yb 64 21 samples sample NNS cord-282990-qb4wk4yb 64 22 were be VBD cord-282990-qb4wk4yb 64 23 handled handle VBN cord-282990-qb4wk4yb 64 24 in in IN cord-282990-qb4wk4yb 64 25 the the DT cord-282990-qb4wk4yb 64 26 BSL-2 BSL-2 NNP cord-282990-qb4wk4yb 64 27 laboratory laboratory NN cord-282990-qb4wk4yb 64 28 supplied supply VBN cord-282990-qb4wk4yb 64 29 with with IN cord-282990-qb4wk4yb 64 30 a a DT cord-282990-qb4wk4yb 64 31 certified certify VBN cord-282990-qb4wk4yb 64 32 Class Class NNP cord-282990-qb4wk4yb 64 33 II II NNP cord-282990-qb4wk4yb 64 34 Biosafety Biosafety NNP cord-282990-qb4wk4yb 64 35 Cabinets Cabinets NNPS cord-282990-qb4wk4yb 64 36 ( ( -LRB- cord-282990-qb4wk4yb 64 37 BSC BSC NNP cord-282990-qb4wk4yb 64 38 ) ) -RRB- cord-282990-qb4wk4yb 64 39 , , , cord-282990-qb4wk4yb 64 40 which which WDT cord-282990-qb4wk4yb 64 41 was be VBD cord-282990-qb4wk4yb 64 42 daily daily RB cord-282990-qb4wk4yb 64 43 equipped equip VBN cord-282990-qb4wk4yb 64 44 with with IN cord-282990-qb4wk4yb 64 45 an an DT cord-282990-qb4wk4yb 64 46 internal internal JJ cord-282990-qb4wk4yb 64 47 waste waste NN cord-282990-qb4wk4yb 64 48 ( ( -LRB- cord-282990-qb4wk4yb 64 49 containing contain VBG cord-282990-qb4wk4yb 64 50 0.5 0.5 CD cord-282990-qb4wk4yb 64 51 % % NN cord-282990-qb4wk4yb 64 52 bleach bleach NN cord-282990-qb4wk4yb 64 53 ) ) -RRB- cord-282990-qb4wk4yb 64 54 to to TO cord-282990-qb4wk4yb 64 55 discard discard VB cord-282990-qb4wk4yb 64 56 the the DT cord-282990-qb4wk4yb 64 57 contaminated contaminate VBN cord-282990-qb4wk4yb 64 58 biological biological JJ cord-282990-qb4wk4yb 64 59 materials material NNS cord-282990-qb4wk4yb 64 60 . . . cord-282990-qb4wk4yb 65 1 To to TO cord-282990-qb4wk4yb 65 2 reduce reduce VB cord-282990-qb4wk4yb 65 3 the the DT cord-282990-qb4wk4yb 65 4 risk risk NN cord-282990-qb4wk4yb 65 5 of of IN cord-282990-qb4wk4yb 65 6 breakage breakage NN cord-282990-qb4wk4yb 65 7 , , , cord-282990-qb4wk4yb 65 8 the the DT cord-282990-qb4wk4yb 65 9 samples sample NNS cord-282990-qb4wk4yb 65 10 were be VBD cord-282990-qb4wk4yb 65 11 placed place VBN cord-282990-qb4wk4yb 65 12 in in IN cord-282990-qb4wk4yb 65 13 two two CD cord-282990-qb4wk4yb 65 14 secondary secondary JJ cord-282990-qb4wk4yb 65 15 containers container NNS cord-282990-qb4wk4yb 65 16 that that WDT cord-282990-qb4wk4yb 65 17 were be VBD cord-282990-qb4wk4yb 65 18 opened open VBN cord-282990-qb4wk4yb 65 19 inside inside IN cord-282990-qb4wk4yb 65 20 BSC BSC NNP cord-282990-qb4wk4yb 65 21 . . . cord-282990-qb4wk4yb 66 1 In in IN cord-282990-qb4wk4yb 66 2 a a DT cord-282990-qb4wk4yb 66 3 Class Class NNP cord-282990-qb4wk4yb 66 4 II II NNP cord-282990-qb4wk4yb 66 5 BSC BSC NNP cord-282990-qb4wk4yb 66 6 , , , cord-282990-qb4wk4yb 66 7 personnel personnel NNS cord-282990-qb4wk4yb 66 8 are be VBP cord-282990-qb4wk4yb 66 9 required require VBN cord-282990-qb4wk4yb 66 10 to to TO cord-282990-qb4wk4yb 66 11 wear wear VB cord-282990-qb4wk4yb 66 12 personal personal JJ cord-282990-qb4wk4yb 66 13 protective protective JJ cord-282990-qb4wk4yb 66 14 equipment equipment NN cord-282990-qb4wk4yb 66 15 including include VBG cord-282990-qb4wk4yb 66 16 laboratory laboratory NN cord-282990-qb4wk4yb 66 17 coat coat NN cord-282990-qb4wk4yb 66 18 , , , cord-282990-qb4wk4yb 66 19 eye eye NN cord-282990-qb4wk4yb 66 20 protection protection NN cord-282990-qb4wk4yb 66 21 , , , cord-282990-qb4wk4yb 66 22 fit fit RB cord-282990-qb4wk4yb 66 23 - - HYPH cord-282990-qb4wk4yb 66 24 tested test VBN cord-282990-qb4wk4yb 66 25 N95 N95 NNP cord-282990-qb4wk4yb 66 26 respirator respirator NN cord-282990-qb4wk4yb 66 27 or or CC cord-282990-qb4wk4yb 66 28 surgical surgical JJ cord-282990-qb4wk4yb 66 29 mask mask NN cord-282990-qb4wk4yb 66 30 and and CC cord-282990-qb4wk4yb 66 31 two two CD cord-282990-qb4wk4yb 66 32 pairs pair NNS cord-282990-qb4wk4yb 66 33 of of IN cord-282990-qb4wk4yb 66 34 disposable disposable JJ cord-282990-qb4wk4yb 66 35 gloves glove NNS cord-282990-qb4wk4yb 66 36 . . . cord-282990-qb4wk4yb 67 1 At at IN cord-282990-qb4wk4yb 67 2 the the DT cord-282990-qb4wk4yb 67 3 end end NN cord-282990-qb4wk4yb 67 4 of of IN cord-282990-qb4wk4yb 67 5 the the DT cord-282990-qb4wk4yb 67 6 operation operation NN cord-282990-qb4wk4yb 67 7 , , , cord-282990-qb4wk4yb 67 8 the the DT cord-282990-qb4wk4yb 67 9 outer outer JJ cord-282990-qb4wk4yb 67 10 layer layer NN cord-282990-qb4wk4yb 67 11 of of IN cord-282990-qb4wk4yb 67 12 gloves glove NNS cord-282990-qb4wk4yb 67 13 is be VBZ cord-282990-qb4wk4yb 67 14 discarded discard VBN cord-282990-qb4wk4yb 67 15 into into IN cord-282990-qb4wk4yb 67 16 the the DT cord-282990-qb4wk4yb 67 17 internal internal JJ cord-282990-qb4wk4yb 67 18 waste waste NN cord-282990-qb4wk4yb 67 19 of of IN cord-282990-qb4wk4yb 67 20 BSC BSC NNP cord-282990-qb4wk4yb 67 21 . . . cord-282990-qb4wk4yb 68 1 A a DT cord-282990-qb4wk4yb 68 2 social social JJ cord-282990-qb4wk4yb 68 3 distancing distancing NN cord-282990-qb4wk4yb 68 4 of of IN cord-282990-qb4wk4yb 68 5 at at RB cord-282990-qb4wk4yb 68 6 least least JJS cord-282990-qb4wk4yb 68 7 1 1 CD cord-282990-qb4wk4yb 68 8 m m NN cord-282990-qb4wk4yb 68 9 is be VBZ cord-282990-qb4wk4yb 68 10 strongly strongly RB cord-282990-qb4wk4yb 68 11 recommended recommend VBN cord-282990-qb4wk4yb 68 12 between between IN cord-282990-qb4wk4yb 68 13 people people NNS cord-282990-qb4wk4yb 68 14 inside inside IN cord-282990-qb4wk4yb 68 15 the the DT cord-282990-qb4wk4yb 68 16 laboratory laboratory NN cord-282990-qb4wk4yb 68 17 in in IN cord-282990-qb4wk4yb 68 18 case case NN cord-282990-qb4wk4yb 68 19 a a DT cord-282990-qb4wk4yb 68 20 laboratorian laboratorian NN cord-282990-qb4wk4yb 68 21 is be VBZ cord-282990-qb4wk4yb 68 22 asymptomatically asymptomatically RB cord-282990-qb4wk4yb 68 23 infected infect VBN cord-282990-qb4wk4yb 68 24 and and CC cord-282990-qb4wk4yb 68 25 spreads spread VBZ cord-282990-qb4wk4yb 68 26 the the DT cord-282990-qb4wk4yb 68 27 virus virus NN cord-282990-qb4wk4yb 68 28 . . . cord-282990-qb4wk4yb 69 1 van van NNP cord-282990-qb4wk4yb 69 2 Doremalen Doremalen NNP cord-282990-qb4wk4yb 69 3 et et FW cord-282990-qb4wk4yb 69 4 al al NNP cord-282990-qb4wk4yb 69 5 . . NNP cord-282990-qb4wk4yb 69 6 has have VBZ cord-282990-qb4wk4yb 69 7 reported report VBN cord-282990-qb4wk4yb 69 8 that that IN cord-282990-qb4wk4yb 69 9 SARS SARS NNP cord-282990-qb4wk4yb 69 10 - - HYPH cord-282990-qb4wk4yb 69 11 CoV-2 CoV-2 NNP cord-282990-qb4wk4yb 69 12 can can MD cord-282990-qb4wk4yb 69 13 remain remain VB cord-282990-qb4wk4yb 69 14 infectious infectious JJ cord-282990-qb4wk4yb 69 15 in in IN cord-282990-qb4wk4yb 69 16 aerosols aerosol NNS cord-282990-qb4wk4yb 69 17 for for IN cord-282990-qb4wk4yb 69 18 hours hour NNS cord-282990-qb4wk4yb 69 19 and and CC cord-282990-qb4wk4yb 69 20 on on IN cord-282990-qb4wk4yb 69 21 various various JJ cord-282990-qb4wk4yb 69 22 surfaces surface NNS cord-282990-qb4wk4yb 69 23 up up RP cord-282990-qb4wk4yb 69 24 to to IN cord-282990-qb4wk4yb 69 25 days day NNS cord-282990-qb4wk4yb 69 26 [ [ -LRB- cord-282990-qb4wk4yb 69 27 19 19 CD cord-282990-qb4wk4yb 69 28 ] ] -RRB- cord-282990-qb4wk4yb 69 29 . . . cord-282990-qb4wk4yb 70 1 Therefore therefore RB cord-282990-qb4wk4yb 70 2 , , , cord-282990-qb4wk4yb 70 3 laboratorians laboratorians NNPS cord-282990-qb4wk4yb 70 4 should should MD cord-282990-qb4wk4yb 70 5 take take VB cord-282990-qb4wk4yb 70 6 extra extra JJ cord-282990-qb4wk4yb 70 7 care care NN cord-282990-qb4wk4yb 70 8 and and CC cord-282990-qb4wk4yb 70 9 operate operate VBP cord-282990-qb4wk4yb 70 10 in in IN cord-282990-qb4wk4yb 70 11 a a DT cord-282990-qb4wk4yb 70 12 Class Class NNP cord-282990-qb4wk4yb 70 13 II II NNP cord-282990-qb4wk4yb 70 14 BSC BSC NNP cord-282990-qb4wk4yb 70 15 when when WRB cord-282990-qb4wk4yb 70 16 performing perform VBG cord-282990-qb4wk4yb 70 17 experimental experimental JJ cord-282990-qb4wk4yb 70 18 procedures procedure NNS cord-282990-qb4wk4yb 70 19 that that WDT cord-282990-qb4wk4yb 70 20 may may MD cord-282990-qb4wk4yb 70 21 generate generate VB cord-282990-qb4wk4yb 70 22 aerosols aerosol NNS cord-282990-qb4wk4yb 70 23 or or CC cord-282990-qb4wk4yb 70 24 droplets droplet NNS cord-282990-qb4wk4yb 70 25 ( ( -LRB- cord-282990-qb4wk4yb 70 26 e.g. e.g. RB cord-282990-qb4wk4yb 70 27 , , , cord-282990-qb4wk4yb 70 28 vortexing vortexing NN cord-282990-qb4wk4yb 70 29 , , , cord-282990-qb4wk4yb 70 30 mixing mixing NN cord-282990-qb4wk4yb 70 31 , , , cord-282990-qb4wk4yb 70 32 plate plate NN cord-282990-qb4wk4yb 70 33 washing washing NN cord-282990-qb4wk4yb 70 34 , , , cord-282990-qb4wk4yb 70 35 sonication sonication NN cord-282990-qb4wk4yb 70 36 and and CC cord-282990-qb4wk4yb 70 37 centrifugation centrifugation NN cord-282990-qb4wk4yb 70 38 ) ) -RRB- cord-282990-qb4wk4yb 70 39 . . . cord-282990-qb4wk4yb 71 1 It -PRON- PRP cord-282990-qb4wk4yb 71 2 is be VBZ cord-282990-qb4wk4yb 71 3 highly highly RB cord-282990-qb4wk4yb 71 4 suggested suggest VBN cord-282990-qb4wk4yb 71 5 to to TO cord-282990-qb4wk4yb 71 6 use use VB cord-282990-qb4wk4yb 71 7 safety safety NN cord-282990-qb4wk4yb 71 8 buckets bucket NNS cord-282990-qb4wk4yb 71 9 or or CC cord-282990-qb4wk4yb 71 10 sealed seal VBN cord-282990-qb4wk4yb 71 11 rotors rotor NNS cord-282990-qb4wk4yb 71 12 for for IN cord-282990-qb4wk4yb 71 13 centrifuges centrifuge NNS cord-282990-qb4wk4yb 71 14 . . . cord-282990-qb4wk4yb 72 1 In in IN cord-282990-qb4wk4yb 72 2 addition addition NN cord-282990-qb4wk4yb 72 3 , , , cord-282990-qb4wk4yb 72 4 the the DT cord-282990-qb4wk4yb 72 5 surfaces surface NNS cord-282990-qb4wk4yb 72 6 of of IN cord-282990-qb4wk4yb 72 7 laboratory laboratory NN cord-282990-qb4wk4yb 72 8 bench bench NN cord-282990-qb4wk4yb 72 9 must must MD cord-282990-qb4wk4yb 72 10 be be VB cord-282990-qb4wk4yb 72 11 thoroughly thoroughly RB cord-282990-qb4wk4yb 72 12 cleaned clean VBN cord-282990-qb4wk4yb 72 13 with with IN cord-282990-qb4wk4yb 72 14 62 62 CD cord-282990-qb4wk4yb 72 15 - - SYM cord-282990-qb4wk4yb 72 16 71 71 CD cord-282990-qb4wk4yb 72 17 % % NN cord-282990-qb4wk4yb 72 18 ethanol ethanol NN cord-282990-qb4wk4yb 72 19 or or CC cord-282990-qb4wk4yb 72 20 other other JJ cord-282990-qb4wk4yb 72 21 disinfectants disinfectant NNS cord-282990-qb4wk4yb 72 22 after after IN cord-282990-qb4wk4yb 72 23 use use NN cord-282990-qb4wk4yb 72 24 [ [ -LRB- cord-282990-qb4wk4yb 72 25 18 18 CD cord-282990-qb4wk4yb 72 26 ] ] -RRB- cord-282990-qb4wk4yb 72 27 . . . cord-282990-qb4wk4yb 73 1 If if IN cord-282990-qb4wk4yb 73 2 a a DT cord-282990-qb4wk4yb 73 3 potential potential JJ cord-282990-qb4wk4yb 73 4 exposure exposure NN cord-282990-qb4wk4yb 73 5 to to IN cord-282990-qb4wk4yb 73 6 infectious infectious JJ cord-282990-qb4wk4yb 73 7 materials material NNS cord-282990-qb4wk4yb 73 8 happens happen VBZ cord-282990-qb4wk4yb 73 9 , , , cord-282990-qb4wk4yb 73 10 the the DT cord-282990-qb4wk4yb 73 11 line line NN cord-282990-qb4wk4yb 73 12 manager manager NN cord-282990-qb4wk4yb 73 13 and and CC cord-282990-qb4wk4yb 73 14 Environment Environment NNP cord-282990-qb4wk4yb 73 15 , , , cord-282990-qb4wk4yb 73 16 Health Health NNP cord-282990-qb4wk4yb 73 17 , , , cord-282990-qb4wk4yb 73 18 and and CC cord-282990-qb4wk4yb 73 19 Safety Safety NNP cord-282990-qb4wk4yb 73 20 department department NN cord-282990-qb4wk4yb 73 21 should should MD cord-282990-qb4wk4yb 73 22 be be VB cord-282990-qb4wk4yb 73 23 immediately immediately RB cord-282990-qb4wk4yb 73 24 reported report VBN cord-282990-qb4wk4yb 73 25 . . . cord-282990-qb4wk4yb 74 1 The the DT cord-282990-qb4wk4yb 74 2 COVID-19 COVID-19 NNP cord-282990-qb4wk4yb 74 3 pandemic pandemic NN cord-282990-qb4wk4yb 74 4 has have VBZ cord-282990-qb4wk4yb 74 5 had have VBN cord-282990-qb4wk4yb 74 6 and and CC cord-282990-qb4wk4yb 74 7 will will MD cord-282990-qb4wk4yb 74 8 continue continue VB cord-282990-qb4wk4yb 74 9 to to TO cord-282990-qb4wk4yb 74 10 have have VB cord-282990-qb4wk4yb 74 11 a a DT cord-282990-qb4wk4yb 74 12 huge huge JJ cord-282990-qb4wk4yb 74 13 impact impact NN cord-282990-qb4wk4yb 74 14 on on IN cord-282990-qb4wk4yb 74 15 the the DT cord-282990-qb4wk4yb 74 16 entire entire JJ cord-282990-qb4wk4yb 74 17 world world NN cord-282990-qb4wk4yb 74 18 . . . cord-282990-qb4wk4yb 75 1 Bioanalytical bioanalytical JJ cord-282990-qb4wk4yb 75 2 laboratories laboratory NNS cord-282990-qb4wk4yb 75 3 have have VBP cord-282990-qb4wk4yb 75 4 had have VBN cord-282990-qb4wk4yb 75 5 and and CC cord-282990-qb4wk4yb 75 6 will will MD cord-282990-qb4wk4yb 75 7 continue continue VB cord-282990-qb4wk4yb 75 8 to to TO cord-282990-qb4wk4yb 75 9 play play VB cord-282990-qb4wk4yb 75 10 an an DT cord-282990-qb4wk4yb 75 11 important important JJ cord-282990-qb4wk4yb 75 12 role role NN cord-282990-qb4wk4yb 75 13 in in IN cord-282990-qb4wk4yb 75 14 the the DT cord-282990-qb4wk4yb 75 15 development development NN cord-282990-qb4wk4yb 75 16 of of IN cord-282990-qb4wk4yb 75 17 treatments treatment NNS cord-282990-qb4wk4yb 75 18 and and CC cord-282990-qb4wk4yb 75 19 vaccines vaccine NNS cord-282990-qb4wk4yb 75 20 against against IN cord-282990-qb4wk4yb 75 21 this this DT cord-282990-qb4wk4yb 75 22 deadly deadly JJ cord-282990-qb4wk4yb 75 23 disease disease NN cord-282990-qb4wk4yb 75 24 . . . cord-282990-qb4wk4yb 76 1 Due due IN cord-282990-qb4wk4yb 76 2 to to IN cord-282990-qb4wk4yb 76 3 the the DT cord-282990-qb4wk4yb 76 4 high high JJ cord-282990-qb4wk4yb 76 5 demand demand NN cord-282990-qb4wk4yb 76 6 for for IN cord-282990-qb4wk4yb 76 7 rapid rapid JJ cord-282990-qb4wk4yb 76 8 diagnosis diagnosis NN cord-282990-qb4wk4yb 76 9 and and CC cord-282990-qb4wk4yb 76 10 the the DT cord-282990-qb4wk4yb 76 11 historical historical JJ cord-282990-qb4wk4yb 76 12 speed speed NN cord-282990-qb4wk4yb 76 13 and and CC cord-282990-qb4wk4yb 76 14 diversity diversity NN cord-282990-qb4wk4yb 76 15 of of IN cord-282990-qb4wk4yb 76 16 currently currently RB cord-282990-qb4wk4yb 76 17 planned plan VBN cord-282990-qb4wk4yb 76 18 and and CC cord-282990-qb4wk4yb 76 19 ongoing ongoing JJ cord-282990-qb4wk4yb 76 20 clinical clinical JJ cord-282990-qb4wk4yb 76 21 trials trial NNS cord-282990-qb4wk4yb 76 22 , , , cord-282990-qb4wk4yb 76 23 large large JJ cord-282990-qb4wk4yb 76 24 numbers number NNS cord-282990-qb4wk4yb 76 25 of of IN cord-282990-qb4wk4yb 76 26 clinical clinical JJ cord-282990-qb4wk4yb 76 27 specimens specimen NNS cord-282990-qb4wk4yb 76 28 from from IN cord-282990-qb4wk4yb 76 29 COVID-19 covid-19 JJ cord-282990-qb4wk4yb 76 30 patients patient NNS cord-282990-qb4wk4yb 76 31 need need VBP cord-282990-qb4wk4yb 76 32 to to TO cord-282990-qb4wk4yb 76 33 be be VB cord-282990-qb4wk4yb 76 34 analyzed analyze VBN cord-282990-qb4wk4yb 76 35 daily daily RB cord-282990-qb4wk4yb 76 36 in in IN cord-282990-qb4wk4yb 76 37 bioanalytical bioanalytical JJ cord-282990-qb4wk4yb 76 38 laboratories laboratory NNS cord-282990-qb4wk4yb 76 39 around around IN cord-282990-qb4wk4yb 76 40 the the DT cord-282990-qb4wk4yb 76 41 world world NN cord-282990-qb4wk4yb 76 42 . . . cord-282990-qb4wk4yb 77 1 This this DT cord-282990-qb4wk4yb 77 2 undoubtedly undoubtedly RB cord-282990-qb4wk4yb 77 3 shows show VBZ cord-282990-qb4wk4yb 77 4 the the DT cord-282990-qb4wk4yb 77 5 commitment commitment NN cord-282990-qb4wk4yb 77 6 of of IN cord-282990-qb4wk4yb 77 7 bioanalytical bioanalytical JJ cord-282990-qb4wk4yb 77 8 scientists scientist NNS cord-282990-qb4wk4yb 77 9 to to TO cord-282990-qb4wk4yb 77 10 improve improve VB cord-282990-qb4wk4yb 77 11 the the DT cord-282990-qb4wk4yb 77 12 public public JJ cord-282990-qb4wk4yb 77 13 health health NN cord-282990-qb4wk4yb 77 14 . . . cord-282990-qb4wk4yb 78 1 At at IN cord-282990-qb4wk4yb 78 2 the the DT cord-282990-qb4wk4yb 78 3 same same JJ cord-282990-qb4wk4yb 78 4 time time NN cord-282990-qb4wk4yb 78 5 , , , cord-282990-qb4wk4yb 78 6 the the DT cord-282990-qb4wk4yb 78 7 laboratory laboratory NN cord-282990-qb4wk4yb 78 8 management management NN cord-282990-qb4wk4yb 78 9 is be VBZ cord-282990-qb4wk4yb 78 10 responsible responsible JJ cord-282990-qb4wk4yb 78 11 for for IN cord-282990-qb4wk4yb 78 12 providing provide VBG cord-282990-qb4wk4yb 78 13 a a DT cord-282990-qb4wk4yb 78 14 safe safe JJ cord-282990-qb4wk4yb 78 15 environment environment NN cord-282990-qb4wk4yb 78 16 for for IN cord-282990-qb4wk4yb 78 17 those those DT cord-282990-qb4wk4yb 78 18 who who WP cord-282990-qb4wk4yb 78 19 are be VBP cord-282990-qb4wk4yb 78 20 delivering deliver VBG cord-282990-qb4wk4yb 78 21 high high JJ cord-282990-qb4wk4yb 78 22 - - HYPH cord-282990-qb4wk4yb 78 23 quality quality NN cord-282990-qb4wk4yb 78 24 results result NNS cord-282990-qb4wk4yb 78 25 . . . cord-282990-qb4wk4yb 79 1 Although although IN cord-282990-qb4wk4yb 79 2 SARS SARS NNP cord-282990-qb4wk4yb 79 3 - - HYPH cord-282990-qb4wk4yb 79 4 CoV-2 CoV-2 NNP cord-282990-qb4wk4yb 79 5 is be VBZ cord-282990-qb4wk4yb 79 6 highly highly RB cord-282990-qb4wk4yb 79 7 contagious contagious JJ cord-282990-qb4wk4yb 79 8 , , , cord-282990-qb4wk4yb 79 9 the the DT cord-282990-qb4wk4yb 79 10 risk risk NN cord-282990-qb4wk4yb 79 11 of of IN cord-282990-qb4wk4yb 79 12 processing process VBG cord-282990-qb4wk4yb 79 13 specimens specimen NNS cord-282990-qb4wk4yb 79 14 containing contain VBG cord-282990-qb4wk4yb 79 15 SARS SARS NNP cord-282990-qb4wk4yb 79 16 - - HYPH cord-282990-qb4wk4yb 79 17 CoV-2 CoV-2 NNP cord-282990-qb4wk4yb 79 18 is be VBZ cord-282990-qb4wk4yb 79 19 controllable controllable JJ cord-282990-qb4wk4yb 79 20 and and CC cord-282990-qb4wk4yb 79 21 many many JJ cord-282990-qb4wk4yb 79 22 reported report VBN cord-282990-qb4wk4yb 79 23 protocols protocol NNS cord-282990-qb4wk4yb 79 24 have have VBP cord-282990-qb4wk4yb 79 25 proven prove VBN cord-282990-qb4wk4yb 79 26 to to TO cord-282990-qb4wk4yb 79 27 effectively effectively RB cord-282990-qb4wk4yb 79 28 inactivate inactivate VB cord-282990-qb4wk4yb 79 29 viruses virus NNS cord-282990-qb4wk4yb 79 30 before before IN cord-282990-qb4wk4yb 79 31 sample sample NN cord-282990-qb4wk4yb 79 32 processing processing NN cord-282990-qb4wk4yb 79 33 . . . cord-282990-qb4wk4yb 80 1 However however RB cord-282990-qb4wk4yb 80 2 , , , cord-282990-qb4wk4yb 80 3 knowledge knowledge NN cord-282990-qb4wk4yb 80 4 about about IN cord-282990-qb4wk4yb 80 5 SARS SARS NNP cord-282990-qb4wk4yb 80 6 - - HYPH cord-282990-qb4wk4yb 80 7 CoV-2 CoV-2 NNP cord-282990-qb4wk4yb 80 8 is be VBZ cord-282990-qb4wk4yb 80 9 still still RB cord-282990-qb4wk4yb 80 10 limited limited JJ cord-282990-qb4wk4yb 80 11 . . . cord-282990-qb4wk4yb 81 1 To to TO cord-282990-qb4wk4yb 81 2 ensure ensure VB cord-282990-qb4wk4yb 81 3 safety safety NN cord-282990-qb4wk4yb 81 4 , , , cord-282990-qb4wk4yb 81 5 staffs staff NNS cord-282990-qb4wk4yb 81 6 handling handle VBG cord-282990-qb4wk4yb 81 7 clinical clinical JJ cord-282990-qb4wk4yb 81 8 specimens specimen NNS cord-282990-qb4wk4yb 81 9 from from IN cord-282990-qb4wk4yb 81 10 COVID-19 covid-19 JJ cord-282990-qb4wk4yb 81 11 patients patient NNS cord-282990-qb4wk4yb 81 12 should should MD cord-282990-qb4wk4yb 81 13 not not RB cord-282990-qb4wk4yb 81 14 underestimate underestimate VB cord-282990-qb4wk4yb 81 15 the the DT cord-282990-qb4wk4yb 81 16 infectivity infectivity NN cord-282990-qb4wk4yb 81 17 of of IN cord-282990-qb4wk4yb 81 18 samples sample NNS cord-282990-qb4wk4yb 81 19 and and CC cord-282990-qb4wk4yb 81 20 need need VBP cord-282990-qb4wk4yb 81 21 to to TO cord-282990-qb4wk4yb 81 22 strictly strictly RB cord-282990-qb4wk4yb 81 23 follow follow VB cord-282990-qb4wk4yb 81 24 the the DT cord-282990-qb4wk4yb 81 25 laboratory laboratory NN cord-282990-qb4wk4yb 81 26 biosafety biosafety NN cord-282990-qb4wk4yb 81 27 practices practice NNS cord-282990-qb4wk4yb 81 28 . . . cord-282990-qb4wk4yb 82 1 Detectable detectable JJ cord-282990-qb4wk4yb 82 2 serum serum NN cord-282990-qb4wk4yb 82 3 SARS SARS NNP cord-282990-qb4wk4yb 82 4 - - HYPH cord-282990-qb4wk4yb 82 5 CoV-2 CoV-2 NNP cord-282990-qb4wk4yb 82 6 viral viral JJ cord-282990-qb4wk4yb 82 7 load load NN cord-282990-qb4wk4yb 82 8 ( ( -LRB- cord-282990-qb4wk4yb 82 9 RNAaemia RNAaemia NNP cord-282990-qb4wk4yb 82 10 ) ) -RRB- cord-282990-qb4wk4yb 82 11 is be VBZ cord-282990-qb4wk4yb 82 12 closely closely RB cord-282990-qb4wk4yb 82 13 correlated correlate VBN cord-282990-qb4wk4yb 82 14 with with IN cord-282990-qb4wk4yb 82 15 drastically drastically RB cord-282990-qb4wk4yb 82 16 elevated elevate VBN cord-282990-qb4wk4yb 82 17 interleukin interleukin NN cord-282990-qb4wk4yb 82 18 6 6 CD cord-282990-qb4wk4yb 82 19 ( ( -LRB- cord-282990-qb4wk4yb 82 20 IL-6 IL-6 NNP cord-282990-qb4wk4yb 82 21 ) ) -RRB- cord-282990-qb4wk4yb 82 22 level level NN cord-282990-qb4wk4yb 82 23 in in IN cord-282990-qb4wk4yb 82 24 critically critically RB cord-282990-qb4wk4yb 82 25 ill ill JJ cord-282990-qb4wk4yb 82 26 COVID-19 COVID-19 NNP cord-282990-qb4wk4yb 82 27 patients patient NNS cord-282990-qb4wk4yb 82 28 SARS SARS NNP cord-282990-qb4wk4yb 82 29 - - HYPH cord-282990-qb4wk4yb 82 30 CoV-2 CoV-2 NNP cord-282990-qb4wk4yb 82 31 can can MD cord-282990-qb4wk4yb 82 32 be be VB cord-282990-qb4wk4yb 82 33 detected detect VBN cord-282990-qb4wk4yb 82 34 in in IN cord-282990-qb4wk4yb 82 35 urine urine NN cord-282990-qb4wk4yb 82 36 , , , cord-282990-qb4wk4yb 82 37 blood blood NN cord-282990-qb4wk4yb 82 38 , , , cord-282990-qb4wk4yb 82 39 anal anal JJ cord-282990-qb4wk4yb 82 40 swabs swab NNS cord-282990-qb4wk4yb 82 41 , , , cord-282990-qb4wk4yb 82 42 and and CC cord-282990-qb4wk4yb 82 43 oropharyngeal oropharyngeal JJ cord-282990-qb4wk4yb 82 44 swabs swab NNS cord-282990-qb4wk4yb 82 45 specimens specimen NNS cord-282990-qb4wk4yb 82 46 Clinical clinical JJ cord-282990-qb4wk4yb 82 47 features feature NNS cord-282990-qb4wk4yb 82 48 of of IN cord-282990-qb4wk4yb 82 49 patients patient NNS cord-282990-qb4wk4yb 82 50 infected infect VBN cord-282990-qb4wk4yb 82 51 with with IN cord-282990-qb4wk4yb 82 52 2019 2019 CD cord-282990-qb4wk4yb 82 53 novel novel JJ cord-282990-qb4wk4yb 82 54 coronavirus coronavirus NN cord-282990-qb4wk4yb 82 55 in in IN cord-282990-qb4wk4yb 82 56 Wuhan Wuhan NNP cord-282990-qb4wk4yb 82 57 Coronavirus Coronavirus NNP cord-282990-qb4wk4yb 82 58 disease disease NN cord-282990-qb4wk4yb 82 59 2019 2019 CD cord-282990-qb4wk4yb 82 60 : : : cord-282990-qb4wk4yb 83 1 coronaviruses coronaviruse NNS cord-282990-qb4wk4yb 83 2 and and CC cord-282990-qb4wk4yb 83 3 blood blood NN cord-282990-qb4wk4yb 83 4 safety safety NN cord-282990-qb4wk4yb 83 5 Quantitative quantitative JJ cord-282990-qb4wk4yb 83 6 detection detection NN cord-282990-qb4wk4yb 83 7 and and CC cord-282990-qb4wk4yb 83 8 viral viral JJ cord-282990-qb4wk4yb 83 9 load load NN cord-282990-qb4wk4yb 83 10 analysis analysis NN cord-282990-qb4wk4yb 83 11 of of IN cord-282990-qb4wk4yb 83 12 SARS SARS NNP cord-282990-qb4wk4yb 83 13 - - HYPH cord-282990-qb4wk4yb 83 14 CoV-2 CoV-2 NNP cord-282990-qb4wk4yb 83 15 in in IN cord-282990-qb4wk4yb 83 16 infected infected JJ cord-282990-qb4wk4yb 83 17 patients patient NNS cord-282990-qb4wk4yb 83 18 SARS SARS NNP cord-282990-qb4wk4yb 83 19 - - HYPH cord-282990-qb4wk4yb 83 20 CoV-2 CoV-2 NNP cord-282990-qb4wk4yb 83 21 viral viral JJ cord-282990-qb4wk4yb 83 22 load load NN cord-282990-qb4wk4yb 83 23 in in IN cord-282990-qb4wk4yb 83 24 clinical clinical JJ cord-282990-qb4wk4yb 83 25 samples sample NNS cord-282990-qb4wk4yb 83 26 of of IN cord-282990-qb4wk4yb 83 27 critically critically RB cord-282990-qb4wk4yb 83 28 Ill ill JJ cord-282990-qb4wk4yb 83 29 patients patient NNS cord-282990-qb4wk4yb 83 30 Detection Detection NNP cord-282990-qb4wk4yb 83 31 of of IN cord-282990-qb4wk4yb 83 32 SARS SARS NNP cord-282990-qb4wk4yb 83 33 - - HYPH cord-282990-qb4wk4yb 83 34 CoV-2 CoV-2 NNP cord-282990-qb4wk4yb 83 35 in in IN cord-282990-qb4wk4yb 83 36 different different JJ cord-282990-qb4wk4yb 83 37 types type NNS cord-282990-qb4wk4yb 83 38 of of IN cord-282990-qb4wk4yb 83 39 clinical clinical JJ cord-282990-qb4wk4yb 83 40 specimens specimen NNS cord-282990-qb4wk4yb 83 41 Safety Safety NNP cord-282990-qb4wk4yb 83 42 considerations consideration NNS cord-282990-qb4wk4yb 83 43 in in IN cord-282990-qb4wk4yb 83 44 the the DT cord-282990-qb4wk4yb 83 45 laboratory laboratory NN cord-282990-qb4wk4yb 83 46 testing testing NN cord-282990-qb4wk4yb 83 47 of of IN cord-282990-qb4wk4yb 83 48 specimens specimen NNS cord-282990-qb4wk4yb 83 49 suspected suspect VBN cord-282990-qb4wk4yb 83 50 or or CC cord-282990-qb4wk4yb 83 51 known know VBN cord-282990-qb4wk4yb 83 52 to to TO cord-282990-qb4wk4yb 83 53 contain contain VB cord-282990-qb4wk4yb 83 54 the the DT cord-282990-qb4wk4yb 83 55 severe severe JJ cord-282990-qb4wk4yb 83 56 acute acute JJ cord-282990-qb4wk4yb 83 57 respiratory respiratory JJ cord-282990-qb4wk4yb 83 58 syndrome syndrome NN cord-282990-qb4wk4yb 83 59 coronavirus coronavirus NN cord-282990-qb4wk4yb 83 60 2 2 CD cord-282990-qb4wk4yb 84 1 ( ( -LRB- cord-282990-qb4wk4yb 84 2 SARS SARS NNP cord-282990-qb4wk4yb 84 3 - - HYPH cord-282990-qb4wk4yb 84 4 CoV-2 CoV-2 NNP cord-282990-qb4wk4yb 84 5 ) ) -RRB- cord-282990-qb4wk4yb 84 6 Handling handling NN cord-282990-qb4wk4yb 84 7 and and CC cord-282990-qb4wk4yb 84 8 processing processing NN cord-282990-qb4wk4yb 84 9 of of IN cord-282990-qb4wk4yb 84 10 blood blood NN cord-282990-qb4wk4yb 84 11 specimens specimen NNS cord-282990-qb4wk4yb 84 12 from from IN cord-282990-qb4wk4yb 84 13 patients patient NNS cord-282990-qb4wk4yb 84 14 with with IN cord-282990-qb4wk4yb 84 15 COVID-19 COVID-19 NNP cord-282990-qb4wk4yb 84 16 for for IN cord-282990-qb4wk4yb 84 17 safe safe JJ cord-282990-qb4wk4yb 84 18 studies study NNS cord-282990-qb4wk4yb 84 19 on on IN cord-282990-qb4wk4yb 84 20 cell cell NN cord-282990-qb4wk4yb 84 21 phenotype phenotype NN cord-282990-qb4wk4yb 84 22 and and CC cord-282990-qb4wk4yb 84 23 cytokine cytokine NN cord-282990-qb4wk4yb 84 24 storm storm NN cord-282990-qb4wk4yb 84 25 Centers Centers NNPS cord-282990-qb4wk4yb 84 26 for for IN cord-282990-qb4wk4yb 84 27 Disease Disease NNP cord-282990-qb4wk4yb 84 28 Control Control NNP cord-282990-qb4wk4yb 84 29 and and CC cord-282990-qb4wk4yb 84 30 Prevention Prevention NNP cord-282990-qb4wk4yb 84 31 . . . cord-282990-qb4wk4yb 85 1 Interim Interim NNP cord-282990-qb4wk4yb 85 2 Laboratory Laboratory NNP cord-282990-qb4wk4yb 85 3 Biosafety Biosafety NNP cord-282990-qb4wk4yb 85 4 Guidelines Guidelines NNPS cord-282990-qb4wk4yb 85 5 for for IN cord-282990-qb4wk4yb 85 6 Handling handling NN cord-282990-qb4wk4yb 85 7 and and CC cord-282990-qb4wk4yb 85 8 Processing processing NN cord-282990-qb4wk4yb 85 9 Specimens specimen NNS cord-282990-qb4wk4yb 86 1 Associated associate VBN cord-282990-qb4wk4yb 86 2 with with IN cord-282990-qb4wk4yb 86 3 Coronavirus Coronavirus NNP cord-282990-qb4wk4yb 86 4 Disease Disease NNP cord-282990-qb4wk4yb 86 5 Effective effective JJ cord-282990-qb4wk4yb 86 6 heat heat NN cord-282990-qb4wk4yb 86 7 inactivation inactivation NN cord-282990-qb4wk4yb 86 8 of of IN cord-282990-qb4wk4yb 86 9 SARS SARS NNP cord-282990-qb4wk4yb 86 10 - - HYPH cord-282990-qb4wk4yb 86 11 CoV-2 CoV-2 NNP cord-282990-qb4wk4yb 86 12 Evaluation Evaluation NNP cord-282990-qb4wk4yb 86 13 of of IN cord-282990-qb4wk4yb 86 14 heating heating NN cord-282990-qb4wk4yb 86 15 and and CC cord-282990-qb4wk4yb 86 16 chemical chemical NN cord-282990-qb4wk4yb 86 17 protocols protocol NNS cord-282990-qb4wk4yb 86 18 for for IN cord-282990-qb4wk4yb 86 19 inactivating inactivate VBG cord-282990-qb4wk4yb 86 20 SARS SARS NNP cord-282990-qb4wk4yb 86 21 - - HYPH cord-282990-qb4wk4yb 86 22 CoV-2 CoV-2 NNP cord-282990-qb4wk4yb 86 23 SARS SARS NNP cord-282990-qb4wk4yb 86 24 - - HYPH cord-282990-qb4wk4yb 86 25 CoV-2 CoV-2 NNP cord-282990-qb4wk4yb 86 26 detection detection NN cord-282990-qb4wk4yb 86 27 using use VBG cord-282990-qb4wk4yb 86 28 an an DT cord-282990-qb4wk4yb 86 29 isothermal isothermal JJ cord-282990-qb4wk4yb 86 30 amplification amplification NN cord-282990-qb4wk4yb 86 31 reaction reaction NN cord-282990-qb4wk4yb 86 32 and and CC cord-282990-qb4wk4yb 86 33 a a DT cord-282990-qb4wk4yb 86 34 rapid rapid JJ cord-282990-qb4wk4yb 86 35 , , , cord-282990-qb4wk4yb 86 36 inexpensive inexpensive JJ cord-282990-qb4wk4yb 86 37 protocol protocol NN cord-282990-qb4wk4yb 86 38 for for IN cord-282990-qb4wk4yb 86 39 sample sample NN cord-282990-qb4wk4yb 86 40 inactivation inactivation NN cord-282990-qb4wk4yb 86 41 and and CC cord-282990-qb4wk4yb 86 42 purification purification NN cord-282990-qb4wk4yb 86 43 Inactivation Inactivation NNP cord-282990-qb4wk4yb 86 44 of of IN cord-282990-qb4wk4yb 86 45 severe severe JJ cord-282990-qb4wk4yb 86 46 acute acute JJ cord-282990-qb4wk4yb 86 47 respiratory respiratory JJ cord-282990-qb4wk4yb 86 48 syndrome syndrome NN cord-282990-qb4wk4yb 86 49 coronavirus coronavirus NN cord-282990-qb4wk4yb 86 50 2 2 CD cord-282990-qb4wk4yb 86 51 in in IN cord-282990-qb4wk4yb 86 52 plasma plasma NN cord-282990-qb4wk4yb 86 53 and and CC cord-282990-qb4wk4yb 86 54 platelet platelet NN cord-282990-qb4wk4yb 86 55 products product NNS cord-282990-qb4wk4yb 86 56 using use VBG cord-282990-qb4wk4yb 86 57 a a DT cord-282990-qb4wk4yb 86 58 riboflavin riboflavin NN cord-282990-qb4wk4yb 86 59 and and CC cord-282990-qb4wk4yb 86 60 ultraviolet ultraviolet JJ cord-282990-qb4wk4yb 86 61 light light NN cord-282990-qb4wk4yb 86 62 - - HYPH cord-282990-qb4wk4yb 86 63 based base VBN cord-282990-qb4wk4yb 86 64 photochemical photochemical JJ cord-282990-qb4wk4yb 86 65 treatment treatment NN cord-282990-qb4wk4yb 86 66 Methylene methylene NN cord-282990-qb4wk4yb 86 67 blue blue JJ cord-282990-qb4wk4yb 86 68 photochemical photochemical JJ cord-282990-qb4wk4yb 86 69 treatment treatment NN cord-282990-qb4wk4yb 86 70 as as IN cord-282990-qb4wk4yb 86 71 a a DT cord-282990-qb4wk4yb 86 72 reliable reliable JJ cord-282990-qb4wk4yb 86 73 SARS SARS NNP cord-282990-qb4wk4yb 86 74 - - HYPH cord-282990-qb4wk4yb 86 75 CoV-2 CoV-2 NNP cord-282990-qb4wk4yb 86 76 plasma plasma NN cord-282990-qb4wk4yb 86 77 virus virus NN cord-282990-qb4wk4yb 86 78 inactivation inactivation NN cord-282990-qb4wk4yb 86 79 method method NN cord-282990-qb4wk4yb 86 80 for for IN cord-282990-qb4wk4yb 86 81 blood blood NN cord-282990-qb4wk4yb 86 82 safety safety NN cord-282990-qb4wk4yb 86 83 and and CC cord-282990-qb4wk4yb 86 84 convalescent convalescent JJ cord-282990-qb4wk4yb 86 85 plasma plasma NN cord-282990-qb4wk4yb 86 86 therapy therapy NN cord-282990-qb4wk4yb 86 87 for for IN cord-282990-qb4wk4yb 86 88 the the DT cord-282990-qb4wk4yb 86 89 COVID-19 COVID-19 NNP cord-282990-qb4wk4yb 86 90 outbreak outbreak NN cord-282990-qb4wk4yb 86 91 Heat Heat NNP cord-282990-qb4wk4yb 86 92 inactivation inactivation NN cord-282990-qb4wk4yb 86 93 of of IN cord-282990-qb4wk4yb 86 94 serum serum NN cord-282990-qb4wk4yb 86 95 interferes interfere VBZ cord-282990-qb4wk4yb 86 96 with with IN cord-282990-qb4wk4yb 86 97 the the DT cord-282990-qb4wk4yb 86 98 immunoanalysis immunoanalysis NN cord-282990-qb4wk4yb 86 99 of of IN cord-282990-qb4wk4yb 86 100 antibodies antibody NNS cord-282990-qb4wk4yb 86 101 to to IN cord-282990-qb4wk4yb 86 102 SARS SARS NNP cord-282990-qb4wk4yb 86 103 - - HYPH cord-282990-qb4wk4yb 86 104 CoV-2 CoV-2 NNP cord-282990-qb4wk4yb 86 105 Guidelines Guidelines NNPS cord-282990-qb4wk4yb 86 106 for for IN cord-282990-qb4wk4yb 86 107 Research Research NNP cord-282990-qb4wk4yb 87 1 Involving involve VBG cord-282990-qb4wk4yb 87 2 Recombinant recombinant JJ cord-282990-qb4wk4yb 87 3 or or CC cord-282990-qb4wk4yb 87 4 Synthetic synthetic JJ cord-282990-qb4wk4yb 87 5 Nucleic nucleic JJ cord-282990-qb4wk4yb 87 6 Acid acid NN cord-282990-qb4wk4yb 87 7 Molecules molecule NNS cord-282990-qb4wk4yb 87 8 Biosafety Biosafety NNP cord-282990-qb4wk4yb 87 9 Guidance Guidance NNP cord-282990-qb4wk4yb 87 10 Related relate VBN cord-282990-qb4wk4yb 87 11 to to IN cord-282990-qb4wk4yb 87 12 Coronavirus Coronavirus NNP cord-282990-qb4wk4yb 87 13 Disease Disease NNP cord-282990-qb4wk4yb 87 14 ( ( -LRB- cord-282990-qb4wk4yb 87 15 COVID-19 COVID-19 NNP cord-282990-qb4wk4yb 87 16 ) ) -RRB- cord-282990-qb4wk4yb 87 17 : : : cord-282990-qb4wk4yb 88 1 Interim Interim NNP cord-282990-qb4wk4yb 88 2 Guidance Guidance NNP cord-282990-qb4wk4yb 88 3 Aerosol Aerosol NNP cord-282990-qb4wk4yb 88 4 and and CC cord-282990-qb4wk4yb 88 5 surface surface NN cord-282990-qb4wk4yb 88 6 stability stability NN cord-282990-qb4wk4yb 88 7 of of IN cord-282990-qb4wk4yb 88 8 SARS SARS NNP cord-282990-qb4wk4yb 88 9 - - HYPH cord-282990-qb4wk4yb 88 10 CoV-2 CoV-2 NNP cord-282990-qb4wk4yb 89 1 as as IN cord-282990-qb4wk4yb 89 2 compared compare VBN cord-282990-qb4wk4yb 89 3 with with IN cord-282990-qb4wk4yb 89 4 SARS SARS NNP cord-282990-qb4wk4yb 89 5 - - HYPH cord-282990-qb4wk4yb 89 6 CoV-1 CoV-1 NNP cord-282990-qb4wk4yb 90 1 The the DT cord-282990-qb4wk4yb 90 2 authors author NNS cord-282990-qb4wk4yb 90 3 gratefully gratefully RB cord-282990-qb4wk4yb 90 4 acknowledge acknowledge VBP cord-282990-qb4wk4yb 90 5 M M NNP cord-282990-qb4wk4yb 90 6 Szapacs Szapacs NNP cord-282990-qb4wk4yb 90 7 , , , cord-282990-qb4wk4yb 90 8 C C NNP cord-282990-qb4wk4yb 90 9 Evans Evans NNP cord-282990-qb4wk4yb 90 10 and and CC cord-282990-qb4wk4yb 90 11 E E NNP cord-282990-qb4wk4yb 90 12 Yang Yang NNP cord-282990-qb4wk4yb 90 13 for for IN cord-282990-qb4wk4yb 90 14 supporting support VBG cord-282990-qb4wk4yb 90 15 this this DT cord-282990-qb4wk4yb 90 16 paper.future paper.future NN cord-282990-qb4wk4yb 90 17 science science NN cord-282990-qb4wk4yb 90 18 group group NN cord-282990-qb4wk4yb 90 19 All all DT cord-282990-qb4wk4yb 90 20 authors author NNS cord-282990-qb4wk4yb 90 21 are be VBP cord-282990-qb4wk4yb 90 22 employees employee NNS cord-282990-qb4wk4yb 90 23 of of IN cord-282990-qb4wk4yb 90 24 GSK GSK NNP cord-282990-qb4wk4yb 90 25 , , , cord-282990-qb4wk4yb 90 26 whom whom WP cord-282990-qb4wk4yb 90 27 may may MD cord-282990-qb4wk4yb 90 28 be be VB cord-282990-qb4wk4yb 90 29 eligible eligible JJ cord-282990-qb4wk4yb 90 30 for for IN cord-282990-qb4wk4yb 90 31 stock stock NN cord-282990-qb4wk4yb 90 32 options option NNS cord-282990-qb4wk4yb 90 33 or or CC cord-282990-qb4wk4yb 90 34 have have VBP cord-282990-qb4wk4yb 90 35 stock stock NN cord-282990-qb4wk4yb 90 36 ownership ownership NN cord-282990-qb4wk4yb 90 37 . . . cord-282990-qb4wk4yb 91 1 The the DT cord-282990-qb4wk4yb 91 2 authors author NNS cord-282990-qb4wk4yb 91 3 have have VBP cord-282990-qb4wk4yb 91 4 no no DT cord-282990-qb4wk4yb 91 5 other other JJ cord-282990-qb4wk4yb 91 6 relevant relevant JJ cord-282990-qb4wk4yb 91 7 affiliations affiliation NNS cord-282990-qb4wk4yb 91 8 or or CC cord-282990-qb4wk4yb 91 9 financial financial JJ cord-282990-qb4wk4yb 91 10 involvement involvement NN cord-282990-qb4wk4yb 91 11 with with IN cord-282990-qb4wk4yb 91 12 any any DT cord-282990-qb4wk4yb 91 13 organization organization NN cord-282990-qb4wk4yb 91 14 or or CC cord-282990-qb4wk4yb 91 15 entity entity NN cord-282990-qb4wk4yb 91 16 with with IN cord-282990-qb4wk4yb 91 17 a a DT cord-282990-qb4wk4yb 91 18 financial financial JJ cord-282990-qb4wk4yb 91 19 interest interest NN cord-282990-qb4wk4yb 91 20 in in IN cord-282990-qb4wk4yb 91 21 or or CC cord-282990-qb4wk4yb 91 22 financial financial JJ cord-282990-qb4wk4yb 91 23 conflict conflict NN cord-282990-qb4wk4yb 91 24 with with IN cord-282990-qb4wk4yb 91 25 the the DT cord-282990-qb4wk4yb 91 26 subject subject JJ cord-282990-qb4wk4yb 91 27 matter matter NN cord-282990-qb4wk4yb 91 28 or or CC cord-282990-qb4wk4yb 91 29 materials material NNS cord-282990-qb4wk4yb 91 30 discussed discuss VBN cord-282990-qb4wk4yb 91 31 in in IN cord-282990-qb4wk4yb 91 32 the the DT cord-282990-qb4wk4yb 91 33 manuscript manuscript NN cord-282990-qb4wk4yb 91 34 apart apart RB cord-282990-qb4wk4yb 91 35 from from IN cord-282990-qb4wk4yb 91 36 those those DT cord-282990-qb4wk4yb 91 37 disclosed disclose VBN cord-282990-qb4wk4yb 91 38 . . . cord-282990-qb4wk4yb 92 1 No no DT cord-282990-qb4wk4yb 92 2 writing writing NN cord-282990-qb4wk4yb 92 3 assistance assistance NN cord-282990-qb4wk4yb 92 4 was be VBD cord-282990-qb4wk4yb 92 5 utilized utilize VBN cord-282990-qb4wk4yb 92 6 in in IN cord-282990-qb4wk4yb 92 7 the the DT cord-282990-qb4wk4yb 92 8 production production NN cord-282990-qb4wk4yb 92 9 of of IN cord-282990-qb4wk4yb 92 10 this this DT cord-282990-qb4wk4yb 92 11 manuscript manuscript NN cord-282990-qb4wk4yb 92 12 . . .